{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65999", "l": "Co(I)-[glycine betaine-specific corrinoid protein] + glycine betaine + H(+) <=> methyl-Co(III)-[glycine betaine-specific corrinoid protein] + N,N-dimethylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1471314", "l": "HNP1-3 bind CD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0035613", "l": "RNA stem-loop binding", "d": ["Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50340", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone = 1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44813", "l": "1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-11 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44093", "l": "ATP + CoA + nonadecanoate => AMP + diphosphate + nonadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2129357", "l": "Fibrillin C-terminal processing (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66592", "l": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)", "d": []}, {"i": "EC:4.2.99.18", "l": "\"DNA-(apurinic or apyrimidinic site) lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649733", "l": "mature p21 RAS binds GDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24387", "l": "ATP + deamido-NAD(+) + H2O + L-glutamine <=> AMP + diphosphate + H(+) + L-glutamate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2059926", "l": "NPHP4 protein binds LATS proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080045", "l": "quercetin 3'-O-glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3'-hydroxy group of a quercetin molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60103", "l": "cyanidin + UDP-alpha-D-glucose <=> cyanidin 3-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50074", "l": "ADP + H(+) + phosphate + tauroursodeoxycholate(out) => ATP + H2O + tauroursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693111", "l": "RHOF auto-activates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74716", "l": "Insulin binds the insulin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.14", "l": "\"L-iditol 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69652", "l": "cumene hydroperoxide + 2 glutathione => 2-phenylpropan-2-ol + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63059", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine <=> 5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033717", "l": "gluconate 2-dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5685230", "l": "CHEK1 phosphorylates RAD51 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39976", "l": "2-iminobutanoate + H2O => 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649657", "l": "NEIL1 recognizes and binds FapyG-dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686335", "l": "CSF2RA:CSF2RB binds SFTPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30601", "l": "3 AH2 + all-trans-neurosporene => 15-cis-phytoene + 3 A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202443", "l": "Oligomerization of CARMA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57228", "l": "GDP + glyoxal = N(2)-(1-hydroxy-2-oxoethyl)-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63198", "l": "(10bR,4aS)-oxomaritidine + NADP(+) => (10bR,4aS)-noroxomaritidine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903878", "l": "11-deoxycorticosterone binding", "d": ["Binding to 11-deoxycorticosterone."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008682", "l": "3-demethoxyubiquinol 3-hydroxylase activity", "d": ["Catalysis of the reaction: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22905", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] => gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47521", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isolithocholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196929", "l": "FLAD1 phosphorylates FMN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50726", "l": "(Z)-(4-hydroxyphenyl)acetaldehyde oxime => (E)-4-hydroxyphenylacetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177284", "l": "PKA phosphorylates PDE4B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52128", "l": "a 5'-end adenosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52985", "l": "7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] => 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.5", "l": "\"tyrosine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033208", "l": "UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetylgalactosamine + N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide = UDP + N-acetylgalactosaminyl-N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266303", "l": "Spherical HDL binds C and E apolipoproteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782138", "l": "ERCC5 and RPA bind TC-NER site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.2.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786789", "l": "FLT3LG dimer binds FLT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55283", "l": "13-cis-retinol + tetradecanoyl-CoA <=> 13-cis-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218832", "l": "CDC42:GTP binds PAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42497", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate => 10-deacetyl-2-debenzoylbaccatin III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58079", "l": "1-(11Z-eicosenoyl)-glycerol + H2O <=> (11Z)-eicosenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63275", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 <=> 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55013", "l": "(1S,4R)-1-hydroxylimonen-2-one + NADPH + O2 => (3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32890", "l": "all-trans-beta-carotene + O2 <=> 2 all-trans-retinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24433", "l": "H2O + oxaloacetate => acetate + H(+) + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.330", "l": "\"beta-D-glucosyl crocetin beta-1,6-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0016824", "l": "hydrolase activity, acting on acid halide bonds", "d": ["Catalysis of the hydrolysis of any acid halide bond."]}, {"i": "EC:3.8.-.-", "l": "\"Acting on halide bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60511", "l": "a guanosine in mRNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983424", "l": "Budding of COPII coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66058", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan => indole-3-pyruvate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71130", "l": "H(+)(in) + L-glutamine(out) + Na(+)(out) <=> H(+)(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61584", "l": "cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11292", "l": "2 H(+) + O2 + rifamycin B = H2O2 + rifamycin O", "d": []}, {"i": "EC:1.10.3.6", "l": "\"rifamycin-B oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12813", "l": "L-glutamate = D-glutamate", "d": []}, {"i": "EC:5.1.1.3", "l": "\"glutamate racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45984", "l": "3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28980", "l": "H(+)(out) + nitrite(in) => H(+)(in) + nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53748", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035663", "l": "Toll-like receptor 2 binding", "d": ["Binding to a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73014", "l": "L-leucine(in) <=> L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:1901683", "l": "arsenate ion transmembrane transporter activity", "d": ["Enables the transfer of an arsenate ion from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16098", "l": "acetylpyruvate + H2O => acetate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31007", "l": "(S)-2,3-epoxysqualene = beta-amyrin", "d": []}, {"i": "EC:5.4.99.39", "l": "\"beta-amyrin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18067", "l": "ADP + H(+) + phosphate + phosphonate(in) => ATP + H2O + phosphonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45891", "l": "12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63374", "l": "an S-acyl-L-cysteinyl-[protein] + CoA => an acyl-CoA + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31976", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin => 7beta-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14130", "l": "cholate + NADP(+) => 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867613", "l": "PICALM binds R-SNAREs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58822", "l": "acetate + CO2 + Na(+)(out) => H(+) + malonate + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32970", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35958", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B <=> 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66274", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33320", "l": "a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA => a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36062", "l": "A + dihydrourocanate <=> AH2 + urocanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42816", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904931", "l": "MCM complex binding", "d": ["Binding to an MCM complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12300", "l": "S-adenosyl-L-methionine + uridine(47) in tRNA(Phe) = 3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48685", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O => [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613497", "l": "Unwinding DNA for the nascent transcript (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692376", "l": "BCL2 binds BCL2 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855375", "l": "PTPN22 dissociates from CSK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000035", "l": "acyl binding", "d": ["Binding to an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69119", "l": "glyoxylate + L-tyrosine <=> 3-(4-hydroxyphenyl)pyruvate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602473", "l": "Autocatalytic activation of MMP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159796", "l": "Furin cleaves pro-factor IX to factor IX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76053", "l": "(S)-cis-N-methylscoulerine + S-adenosyl-L-homocysteine => (S)-scoulerine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65207", "l": "(3R)-3-hydroxybutanoyl-CoA + H2O <=> (R)-3-hydroxybutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60830", "l": "a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate => a 5'-end triphospho-adenosine in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047309", "l": "dihydroxyphenylalanine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-dopa = 3,4-dihydroxyphenylpyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173723", "l": "C8 binds C5b:C6:C7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19597", "l": "H2O + L-arginine = L-citrulline + NH4(+)", "d": []}, {"i": "EC:3.5.3.6", "l": "\"arginine deiminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044101", "l": "(R)-citramalyl-CoA lyase activity", "d": ["Catalysis of the reaction: (R)-citramalyl-CoA = pyruvate + acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54388", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59138", "l": "AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine => ATP + citrate + D-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694563", "l": "ABHD10 hydrolyses MPAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42349", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71388", "l": "L-pipecolate(in) + Na(+)(in) => L-pipecolate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5689000", "l": "AADAC deacetylates PHEN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73139", "l": "lithocholate(out) = lithocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10029", "l": "D-glutamate + H2O + O2 => 2-oxoglutarate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33876", "l": "cholesteryl (9Z-octadecenoate) + H2O => (9Z)-octadecenoate + cholesterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614271", "l": "Autocleavage of ADGRG6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176175", "l": "Stalling of DNA replication fork and RPA binding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22805", "l": "(6S,9R)-vomifoliol + NAD(+) => (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15111", "l": "(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH => 2-dehydro-3-deoxy-D-gluconate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12301", "l": "S-adenosyl-L-methionine + uridine(47) in tRNA(Phe) => 3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29974", "l": "2'-deoxyinosine(in) + H(+)(in) <=> 2'-deoxyinosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977136", "l": "Amyloid precursor proteins form ordered fibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56935", "l": "androst-5-en-3beta,17beta-diol + NAD(+) <=> 17beta-hydroxy-androst-5-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31153", "l": "2-oxobutanoate + L-selenocysteine + NH4(+) => H2O + L-selenocystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11611", "l": "[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71484", "l": "H2O + Met-enkephalin => L-phenylalanyl-L-methionine + L-tyrosylglycylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39154", "l": "3-oxooctadecanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyoctadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74003", "l": "A + peniprequinolone = AH2 + yaequinolone E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55097", "l": "(3S)-3-hydroxypentanoyl-CoA + H2O => (3S)-3-hydroxypentanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21520", "l": "2 Fe(III)-[cytochrome b1] + formate = CO2 + 2 Fe(II)-[cytochrome b1] + H(+)", "d": []}, {"i": "EC:1.2.2.1", "l": "\"formate dehydrogenase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047681", "l": "aryl-alcohol dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19016", "l": "dTTP + H2O <=> dTDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444100", "l": "PROT mediates L-proline uptake (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008043", "l": "MAPK8 phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849463", "l": "PTK6 phosphorylates SFPQ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875817", "l": "MET phosphorylates STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029454", "l": "Autophosphorylation of PAK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.3", "l": "\"aldehyde dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14412", "l": "cysteamine + O2 <=> H(+) + hypotaurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805785", "l": "AKT phosphorylates PHF20 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2328037", "l": "Fibrillin-1 binds integrins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59163", "l": "ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] <=> AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58022", "l": "eupatolide + H2O => 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043876", "l": "D-threonine aldolase activity", "d": ["Catalysis of the reaction: D-threonine (or D-allo-threonine) = glycine + acetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65368", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O = a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168412", "l": "MDP elicits a NOD2 response (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017032", "l": "amino acid:potassium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + K+(out) = amino acid(in) + K+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13254", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68599", "l": "(2E,6E)-farnesyl diphosphate <=> beta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21151", "l": "indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose <=> 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222399", "l": "Iron is reduced and separates from mycobactin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63444", "l": "(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + H(+) + oxidized coenzyme F420-0", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016767", "l": "geranylgeranyl-diphosphate geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "71.503963827996756", "identifiers": [{"i": "GO:0016298", "l": "lipase activity", "d": ["Catalysis of the hydrolysis of a lipid or phospholipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64016", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944218", "l": "Association of procollagen type VIII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937343", "l": "NLRC5 interacts with DDX58/IFIH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709109", "l": "DHFR dimer binds DHFR inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59802", "l": "CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => decanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450488", "l": "BRF1 Complex recruits RNA degradation activities (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627369", "l": "SEPT4 binds XIAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0160002", "l": "ADP-D-ribose modification-dependent protein binding", "d": ["Binding to a protein upon ADP-ribosylation of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24991", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitroate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2201341", "l": "Endocytosis of TRAM (TICAM2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49362", "l": "2,2'-dioxospirilloxanthin + H2O => 2',2'-dihydroxy-2-oxospirilloxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36905", "l": "7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine => 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432909", "l": "Interaction of Plectin with Integrin beta 4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32405", "l": "(1R,4R)-dihydrocarvone + H(+) + NADH => (1R,2S,4R)-neodihydrocarveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71872", "l": "(S)-3-hydroxybutanoate(out) + H(+)(out) => (S)-3-hydroxybutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63113", "l": "A + ascofuranol => AH2 + ascofuranone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25535", "l": "ent-copalyl diphosphate <=> diphosphate + ent-cassa-12,15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67270", "l": "sch 210972 => (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13196", "l": "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) <=> 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.1", "l": "\"alkaline phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193482", "l": "25(R) DHCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54261", "l": "2-oxoglutarate + L-asparaginyl-[protein] + O2 => (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53108", "l": "2-hydroxyestrone + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71050", "l": "Trimerization of the FASL:FAS receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2029456", "l": "RAC1 and CDC42 activate PAK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18423", "l": "chloramphenicol 3-acetate + CoA => acetyl-CoA + chloramphenicol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30801", "l": "acetoacetyl-CoA + H(+) + NADH => (3S)-3-hydroxybutanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54766", "l": "[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+) => 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51478", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O => a ribonucleoside 5'-triphosphate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34327", "l": "4-nitrophenol + H(+) + NADPH + O2 = 1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": []}, {"i": "EC:1.14.13.167", "l": "\"4-nitrophenol 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64263", "l": "(9Z,12Z)-octadecadienoyl-CoA + glycine <=> CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45250", "l": "butanoate(in) => butanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36279", "l": "H(+) + NADH + O2 + theophylline = 3-methylxanthine + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169461", "l": "MCM8 mediated fork unwinding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433374", "l": "Processing of SCF isoform 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421835", "l": "trans-Golgi Network Vesicle Scission (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047844", "l": "deoxycytidine deaminase activity", "d": ["Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800279", "l": "TP53 binds the PIDD1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624211", "l": "Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416358", "l": "G alpha (q) inhibits PI3K alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66797", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17762", "l": "an aromatic primary alcohol + NADP(+) => an aromatic aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41390", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate => 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672961", "l": "PP2A dephosphorylates inactive RAFs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48657", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781814", "l": "USP19 deubiquitinates RNF123 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61207", "l": "L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal <=> H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0015424", "l": "ABC-type amino acid transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12775", "l": "CO2 + dihydroclavaminate + H2O + succinate => 2-oxoglutarate + O2 + proclavaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59566", "l": "H(+) + N,N',N'',N'''-tetraacetylchitotetraonate => H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170159", "l": "Translocation of Cdc25 to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694632", "l": "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201669", "l": "Beta-catenin translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14456", "l": "4-(phosphooxy)-L-threonine + NAD(+) <=> (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61417", "l": "(S)-8-oxocitronellyl enol => cis-trans-nepetalactol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57764", "l": "2,6-dinitrotoluene + NADH + O2 = 3-methyl-4-nitrocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659879", "l": "Defective SI does not hydrolyze iMal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34298", "l": "2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose <=> 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64162", "l": "ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase] => ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004947", "l": "bradykinin receptor activity", "d": ["Combining with bradykinin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44941", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O => 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23825", "l": "(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) => 2,3-dihydroxybenzoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28459", "l": "biotin(in) => biotin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004865", "l": "protein serine/threonine phosphatase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0032129", "l": "histone H3K9 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50394", "l": "5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-L-Glu)(n) => H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + oxytetracycline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71427", "l": "3,3'-diiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) = 3,3'-diiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191763", "l": "snRNP:Snurportin complex formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052381", "l": "tRNA dimethylallyltransferase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604752", "l": "Initial activation of proMMP13 by MMP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429730", "l": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69045", "l": "2-nitrobutanedioate => fumarate + H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444691", "l": "Prokineticin receptors bind prokineticin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37273", "l": "ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate => ATP + H2O + L-alanyl-L-glutamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22252", "l": "globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = globoside Gb4Cer (d18:1(4E)) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.79", "l": "\"globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71563", "l": "5-aminomethyl-dUMP in DNA + acetyl-CoA = 5-acetylaminomethyl-dUMP in DNA + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10785", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22167", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> globoside Forssman (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877192", "l": "RUNX1 binds FOXP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29960", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose => alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41457", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047376", "l": "all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity", "d": ["Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0008143", "l": "poly(A) binding", "d": ["Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27690", "l": "ATP + dGDP = ADP + dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68198", "l": "1,2-dihexanoyl-3-tetradecanoylglycerol + CoA => 1,2-dihexanoylglycerol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.-", "l": "\"alpha-Amino-acyl-peptide hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666383", "l": "F8 variant is not cleaved by thrombin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004836", "l": "tyramine-beta hydroxylase activity", "d": ["Catalysis of the hydroxylation of tyramine to form octopamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53767", "l": "allocholate + lithocholoyl-CoA <=> allocholoyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050538", "l": "N-carbamoyl-L-amino-acid hydrolase activity", "d": ["Catalysis of the reaction: N-carbamoyl-L-2-amino acid + H2O = L-2-amino acid + NH3 + CO2. The N-carbamoyl-L-2-amino acid is a 2-ureido carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867613", "l": "PICALM binds R-SNAREs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32222", "l": "all-trans-lycopene <=> gamma-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205319", "l": "Interaction of APS and p-KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33677", "l": "H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2 => H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20090", "l": "acetyl-CoA + L-leucine => CoA + H(+) + N-acetyl-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.-", "l": "\"Other carbon-carbon lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53893", "l": "an S-prenyl-L-cysteine + H2O + O2 => a prenal + H2O2 + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21466", "l": "carbonyl sulfide + NH4(+) => 2 H(+) + H2O + thiocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031760", "l": "Edg-7 lysophosphatidic acid receptor binding", "d": ["Binding to an Edg-7 lysophosphatidic acid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37477", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72326", "l": "3 Na(+)(out) + thiosulfate(out) <=> 3 Na(+)(in) + thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653974", "l": "Ragulator binds Rag dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41303", "l": "H2O + N-dodecanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + dodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19052", "l": "(5R)-5-hydroxy-L-lysine + GTP <=> (5R)-5-phosphooxy-L-lysine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12450", "l": "(R)-pantoate + beta-alanine => (R)-pantothenate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67931", "l": "a 3'-end 2',3'-cyclophospho-uridine-RNA + H2O <=> a 3'-end 3'-phosphouridine-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74271", "l": "an alpha-Kdo-(2->6)-lipid IVA + ATP = a 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12221", "l": "H2O + L-leucine + NAD(+) => 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67209", "l": "H2O + melatonin => 5-methoxytryptamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0008379", "l": "thioredoxin peroxidase activity", "d": ["Catalysis of the reaction: [thioredoxin]-dithiol + hydrogen peroxide = [thioredoxin]-disulfide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37048", "l": "H(+)(out) + L-histidine(out) => H(+)(in) + L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51840", "l": "2 Na(+)(out) + tauroallocholate(out) = 2 Na(+)(in) + tauroallocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53411", "l": "(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420117", "l": "VEGFR2 autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005130", "l": "granulocyte colony-stimulating factor receptor binding", "d": ["Binding to a granulocyte colony-stimulating factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981606", "l": "Myoglobin binds oxygen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25325", "l": "N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = H(+) + phosphocholine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29411", "l": "glycolate(in) + H(+)(in) = glycolate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473184", "l": "Follistatin (FST) binds Activin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420883", "l": "Opsins act as GEFs for G alpha-t (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20726", "l": "a (3E)-enoyl-CoA + H2O => a 4-saturated-(3S)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37409", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944216", "l": "Association of procollagen type XV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805103", "l": "AURKA phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32933", "l": "a cardiolipin + CMP + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23953", "l": "H2O + N-(2-phenylethyl)acetamide => 2-phenylethylamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202164", "l": "Translocation of PDK1 to Plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47891", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1977959", "l": "ERBB4 forms heterodimers with EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63998", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33114", "l": "(2E,6E)-farnesyl diphosphate <=> beta-copaene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.2.-", "l": "\"Acid--alcohol ligases (ester synthases)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53973", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69409", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+) => androst-4-ene-3,11,17-trione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451283", "l": "kainate receptor binds glutamate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625424", "l": "The retrograde IFT train dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35838", "l": "2'-dehydrokanamycin A + H(+) + NADPH <=> kanamycin A + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17755", "l": "(S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine => S-(5-deoxy-D-ribos-5-yl)-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.28", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73324", "l": "(2R,3S)-piscidate + (E)-caffeoyl-CoA => cimicifugate D + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635854", "l": "GLI2,3 are degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56989", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0016917", "l": "GABA receptor activity", "d": ["Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114671", "l": "vWF binds to collagen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851979", "l": "BTNL9 binds immune cell surfaces (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41298", "l": "H2O + N-(hexanoyl)sphing-4-enine <=> hexanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66835", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + preasperterpenoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32130", "l": "2-oxoglutarate + L-proline + O2 <=> cis-4-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18385", "l": "acetone + 2 ATP + 3 H2O + hydrogencarbonate = acetoacetate + 2 AMP + 4 H(+) + 4 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008897", "l": "holo-[acyl-carrier-protein] synthase activity", "d": ["Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940959", "l": "Neurolysin degrades neurotensin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47734", "l": "5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2327746", "l": "FN1 aggregation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9769235", "l": "MAGED1 binds NPAS4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24946", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) <=> (4S)-4-hydroxy-L-glutamate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340226", "l": "CYGB dioxygenates NO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18507", "l": "Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+) => L-lysine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38084", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65049", "l": "4-acetoxybenzyl alcohol + NAD(+) => 4-acetoxybenzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69966", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61915", "l": "ATP + H2O + voriconazole(in) <=> ADP + H(+) + phosphate + voriconazole(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10564", "l": "H2O + oxaloacetate 4-methyl ester = H(+) + methanol + oxaloacetate", "d": []}, {"i": "EC:3.1.1.44", "l": "\"4-methyloxaloacetate esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018814", "l": "RHOT1 hydrolyzes GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66844", "l": "asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase] = asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55133", "l": "ATP + D-alanine + holo-[D-alanyl-carrier protein] => AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75859", "l": "all-trans-4-hydroxy-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-oxo-13,14-dihydroretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944240", "l": "Association of procollagen type III (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944261", "l": "Association of procollagen type XIII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33826", "l": "3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH <=> NAD(+) + tetrahydro-4-hydroxyphenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018747", "l": "RHOQ GEFs activate RHOQ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2562564", "l": "Caspase-8 processing within TLR4 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54265", "l": "2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050604", "l": "taxadiene 5-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: AH(2) + O2 + taxa-4,11-diene = A + H2O + taxa-4(20),11-dien-5alpha-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160874", "l": "HYAL1 hydrolyses (HA)50 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41701", "l": "1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75579", "l": "A + cyathatriol = AH2 + cyathin A3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0071791", "l": "chemokine (C-C motif) ligand 5 binding", "d": ["Binding to chemokine (C-C motif) ligand 5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72103", "l": "Formation of pre-mRNPs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663736", "l": "CHRNA9:CHRNA10 binds acetylcholine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-877187", "l": "P2X7 mediates loss of intracellular K+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50330", "l": "1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997237", "l": "SH2B proteins bind JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198756", "l": "ERK1/2 phosphorylates MSK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874191", "l": "CREB3L2 translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75091", "l": "2 chloride(in) + sulfate(out) = 2 chloride(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202459", "l": "Phosphorylation of Bcl10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018785", "l": "RHOBTB2 binds GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.-", "l": "\"In linear amides\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12983", "l": "glutathione + 2 H(+) + sulfite => H2O + O2 + S-sulfanylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39949", "l": "a fatty acid + a monoacylglycerol + H(+) => 1,3-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52882", "l": "16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16beta,17beta-estriol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41407", "l": "(R)-2-methylpyrrolidine + NADP(+) <=> 2-methyl-1-pyrroline + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31549", "l": "15-cis-4,4'-diapophytoene + 2 diphosphate => 2 (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0003873", "l": "6-phosphofructo-2-kinase activity", "d": ["Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350458", "l": "RHOGAPP190 activates GTP hydrolysis by RHO1:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45487", "l": "H(+) + pyruvate <=> acetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3858489", "l": "ppDVL binds DAAM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709406", "l": "CO binds to Cytochrome c oxidase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36316", "l": "2 H(+) + hexadecanoyl-CoA + 2 NADPH => CoA + hexadecan-1-ol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9773192", "l": "SOX10 binds CDH19 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41081", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-(9Z-octadecenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44645", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70850", "l": "L-arginine(in) + L-cysteine(out) + Na(+)(out) <=> L-arginine(out) + L-cysteine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69151", "l": "H2O + O2 + spermine <=> H2O2 + NH4(+) + spermine monoaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27292", "l": "AH2 + CO2 => A + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28152", "l": "CoA + H(+) + N(1)-acetylspermidine => acetyl-CoA + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2245218", "l": "CDK1 phosphorylates PHF8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42415", "l": "(2R)-2,3-bisphosphoglycerate + ATP + H(+) <=> ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73666", "l": "(E,E)-piperoyl-CoA + pyrrolidine <=> CoA + H(+) + piperyline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375138", "l": "CDO binds BOC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63954", "l": "a sphingoid base + phosphate => a sphingoid 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50807", "l": "glutathione + prostaglandin J2 <=> prostaglandin J2-S-(R)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68989", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35474", "l": "(+)-6a-hydroxymaackiain + S-adenosyl-L-methionine <=> (+)-pisatin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3899291", "l": "SUMOylation of EP300 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66774", "l": "ADP + H(+) + phosphate + uroporphyrin I(out) => ATP + H2O + uroporphyrin I(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17294", "l": "2 H(+) + NADH + O2 + precorrin-3A => H2O + NAD(+) + precorrin-3B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40248", "l": "H2O + rhodomycin D => 10-carboxy-13-deoxycarminomycin + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12940", "l": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23608", "l": "H(+) + H2O + N-isopropylammelide = cyanurate + isopropylamine", "d": []}, {"i": "EC:3.5.4.42", "l": "\"N-isopropylammelide isopropylaminohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66580", "l": "3'-phosphoadenylyl sulfate + bisphenol A = adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49932", "l": "(3E,5Z)-octadienoyl-CoA = (2E,5Z)-octadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388832", "l": "PI3K binds CD28 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9704297", "l": "CHRM2 binds CHRM2 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31439", "l": "(2E,6E)-farnesyl diphosphate = alpha-longipinene + diphosphate", "d": []}, {"i": "EC:4.2.3.80", "l": "\"alpha-longipinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48556", "l": "4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) = 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate", "d": []}, {"i": "EC:2.4.2.54", "l": "\"beta-ribofuranosylphenol 5'-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024967", "l": "BDNF-bound NTRK2 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45866", "l": "4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047853", "l": "difructose-anhydride synthase activity", "d": ["Catalysis of the reaction: H2O + bis-D-fructose 2',1:2,1'-dianhydride = inulobiose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654603", "l": "Activated FGFR2 binds FRS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71671", "l": "glycyl-L-glutamine(out) + H(+)(out) = glycyl-L-glutamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48079", "l": "a primary alcohol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52467", "l": "17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37562", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008496", "l": "mannan endo-1,6-alpha-mannosidase activity", "d": ["Catalysis of the random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2471621", "l": "Endostatin degradation by cathepsins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13998", "l": "3-methyl-2-oxobutanoate + CoA + NAD(+) => 2-methylpropanoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9727349", "l": "XDH dehydrogenates xanthine to form urate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602484", "l": "Activation of proMMP11 by FURIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38701", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59375", "l": "1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112703", "l": "PTPN11 is phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41268", "l": "H2O + N-(15Z-tetracosenoyl)-sphing-4-enine => (15Z)-tetracosenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23970", "l": "(E)-ferulate + 2 H(+) + NADH => (E)-coniferaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40986", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O <=> (9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072572", "l": "poly-ADP-D-ribose binding", "d": ["Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265301", "l": "Corticotropin cleavage from POMC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60645", "l": "3'-phosphoadenylyl sulfate + androsterone => adenosine 3',5'-bisphosphate + androsterone 3alpha-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044198", "l": "zf-TRAF domain binding", "d": ["Binding to a TRAF-type zinc finger domain of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755252", "l": "nsp15 cleaves viral poly(U)-RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42283", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380222", "l": "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139842", "l": "Binding of Syk tyrosine kinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696822", "l": "AKR1B15 reduces EST17b to E1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-984689", "l": "Kinesin-7 is a dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710254", "l": "GSDME oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75317", "l": "chloride(in) + D-serine(in) + 2 Na(+)(in) => chloride(out) + D-serine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692131", "l": "SOX9 binds the FGF9 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627350", "l": "SMAC (DIABLO) binds XIAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2214351", "l": "PLK1 phosphorylates GORASP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192061", "l": "CYP46A1 24-hydroxylates CHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047326", "l": "inositol tetrakisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009817", "l": "Acitretin binds to RAR:RXR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663271", "l": "NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429767", "l": "Passive I- efflux mediated by SMCT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047343", "l": "glucose-1-phosphate cytidylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + CTP = CDP-D-glucose + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25952", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate", "d": []}, {"i": "EC:2.2.1.10", "l": "\"2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18047", "l": "alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+) => 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49505", "l": "phosphinomethylmalate => phosphinomethylisomalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016640", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a cytochrome molecule."]}, {"i": "EC:1.4.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67523", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389083", "l": "Autophosphorylation of PDGF alpha receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956684", "l": "ITCH polyubiquitinates TP73 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928617", "l": "EPHB2 binds KALRN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14669", "l": "D-glyceraldehyde 3-phosphate + H2O + NADP(+) = (2R)-3-phosphoglycerate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51028", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 = 7-chloroindole-3-pyruvate imine dimer + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63798", "l": "C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate => C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602170", "l": "CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-triol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56275", "l": "4 Fe(III)-[cytochrome cL] + H2O + methanol <=> 4 Fe(II)-[cytochrome cL] + formate + 5 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29586", "l": "guanosine(in) + H(+)(out) <=> guanosine(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162099", "l": "abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59458", "l": "H(+) + NADPH + tetradecanal => NADP(+) + tetradecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757256", "l": "MCM3 binds MCM5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58499", "l": "choline + H(+) + NADH + O2 <=> glycolaldehyde + H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801675", "l": "PLK2 phosphorylates NPM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940554", "l": "MMP2 cleaves OPTC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67259", "l": "H2O + NAD(+) + propanal <=> 2 H(+) + NADH + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004132", "l": "dCMP deaminase activity", "d": ["Catalysis of the reaction: dCMP + H2O = dUMP + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28472", "l": "pyridoxine(out) => pyridoxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24999", "l": "N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29232", "l": "cyanate(in) => cyanate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64909", "l": "CTP + 2 H2O => CMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52306", "l": "(2S)-2-acetamido-4-aminobutanoate => H2O + L-ectoine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54939", "l": "(2E)-decenoyl-[ACP] + H(+) + NADH <=> decanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44450", "l": "a 3-oxoacyl-[ACP] + CO2 + CoA => an acyl-CoA + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72722", "l": "(R)-N(6)-dihydrolipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70387", "l": "3-oxosphinganine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050797", "l": "thymidylate synthase (FAD) activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74723", "l": "Endosome acidification (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20745", "l": "NADP(+) + prostaglandin D2 => 15-oxoprostaglandin D2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791143", "l": "Expression of YIF1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26127", "l": "FAD + L-proline <=> (S)-1-pyrroline-5-carboxylate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0033946", "l": "xyloglucan-specific endo-beta-1,4-glucanase activity", "d": ["Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the endohydrolysis of (1->4)-beta-D-glucosidic linkages in xyloglucan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47803", "l": "4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid <=> an aromatic oxo-acid + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173725", "l": "C9 binds C5b:C6:C7:C8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-847070", "l": "Phosphorylated TAK1 dissociates from the TLR3 receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14090", "l": "2-oxoglutarate + glycine => glyoxylate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61793", "l": "ATP + L-tryptophan => diphosphate + L-tryptophyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211193", "l": "Homodimerization  of DFF40 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43422", "l": "1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41904", "l": "3-oxohexadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34151", "l": "3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine = 2-deoxystreptamine + 2-oxoglutaramate", "d": []}, {"i": "EC:2.6.1.101", "l": "\"L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052615", "l": "ent-kaurene oxidase activity", "d": ["Catalysis of the reaction: H+ + NADPH + ent-kaur-16-ene + oxygen = H2O + NADP+ + ent-kaur-16-en-19-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50236", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] = 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35684", "l": "hexadecasphinganine + NADP(+) => 3-oxohexadecasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43450", "l": "(2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48492", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2248891", "l": "Active ARSA translocates to the lysosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28320", "l": "scutellarin + UDP => scutellarein + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854981", "l": "SHC1 in the RET complex is phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31581", "l": "(5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate => (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65917", "l": "L-kynurenine + pyruvate => H2O + kynurenate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70177", "l": "alpha-D-glucose 1-phosphate + D-galactose => beta-D-glucosyl-(1->4)-D-galactose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9689680", "l": "IFNG dimer binds IFNG inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32031", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-curcumene", "d": []}, {"i": "EC:4.2.3.94", "l": "\"gamma-curcumene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5334794", "l": "FABPs bind LCFAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32708", "l": "(2E)-geranyl diphosphate => (2R,4S)-bornyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42235", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.115", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50668", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.344", "l": "\"type 2 galactoside alpha-(1,2)-fucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43659", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191303", "l": "FDPS dimer transfers IPPP to GPP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8939204", "l": "ESTG binds ESR1:chaperone complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17748", "l": "N-acetyl-D-glucosamine + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794414", "l": "Basolateral transport of Cipro to extracellular space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012835", "l": "GDIs block activation of RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18603", "l": "3,4-dihydroxybenzoate + CO2 => 3,4-dihydroxyphthalate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75225", "l": "H(+) + L-fuconate => H2O + L-fucono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26251", "l": "2 H2O + levopimaradienal + NADP(+) => H(+) + levopimaradienol + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682598", "l": "ATM phosphorylates HERC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990003", "l": "IDP phosphatase activity", "d": ["Catalysis of the reaction: IDP + H2O = IMP + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57376", "l": "(S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.166", "l": "\"(S)-N-methylcanadine 1-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928578", "l": "EPH receptors autophosphorylate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31773", "l": "11-cis-retinol + a fatty acid + H(+) => an all-trans-retinyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69485", "l": "dodecan-1-ol + O2 => dodecanal + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33341", "l": "CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75368", "l": "cytidine(in) => cytidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-844447", "l": "NLRP1 senses MDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24906", "l": "L-tyrosine = (E)-4-coumarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14841", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = ent-copalyl diphosphate", "d": []}, {"i": "EC:5.5.1.13", "l": "\"ent-copalyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858475", "l": "TNFSF9 binds TNFRSF9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874079", "l": "PTK2 binds activated MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "56.819009873417293", "identifiers": [{"i": "GO:0016773", "l": "phosphotransferase activity, alcohol group as acceptor", "d": ["Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72263", "l": "chloride(out) + oxalate(in) = chloride(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40647", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026008", "l": "Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602484", "l": "Activation of proMMP11 by FURIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850797", "l": "SPINK6 binds KLK13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11258", "l": "glucosyl-limonin + 2 H(+) + UDP => H2O + limonin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299318", "l": "Activation of TASK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32903", "l": "calciol + O2 + reduced [NADPH--hemoprotein reductase] = calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.24", "l": "\"vitamin D 25-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24697", "l": "(E)-isoeugenol + acetate + NADP(+) <=> (E)-coniferyl acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34671", "l": "3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855161", "l": "I(1,3,4,5,6)P5 transports from the nucleus to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5632738", "l": "DDIT4 binds 14-3-3 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10538", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30121", "l": "dodecanoate + H(+) + holo-[ACP] => dodecanoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45813", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA => a very-long-chain (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0019003", "l": "GDP binding", "d": ["Binding to GDP, guanosine 5'-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668148", "l": "F8 variant is not sulfonated at Y1699 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071551", "l": "RIP homotypic interaction motif binding", "d": ["Binding to a RIP homotypic interaction motif (RHIM) of a protein. The RHIM is a 16-amino-acid motif found in some members, including RIP3, of a family of related kinases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20439", "l": "2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH => 5D-5-O-methyl-chiro-inositol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9032798", "l": "DOCK3 activates RAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19786", "l": "2-oxoglutarate + dihydroclavaminate + O2 => clavaminate + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46140", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71729", "l": "citrate(in) + fumarate(out) => citrate(out) + fumarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41962", "l": "ganglioside GA1 (d18:1(4E)) + H(+) + UDP => ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10084", "l": "3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate + 2 H(+)", "d": []}, {"i": "EC:1.13.11.3", "l": "\"protocatechuate 3,4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59057", "l": "2 methanethiol + NAD(+) => dimethyl disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34705", "l": "(E)-2-epi-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167415", "l": "G-protein alpha subunit is inactivated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30969", "l": "9,9'-di-cis-zeta-carotene => 9,9',15-tri-cis-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404134", "l": "RBP4:atROL binds TTR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41367", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31259", "l": "but-3-ynal + H2O + NAD(+) = 3-butynoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53849", "l": "NAD(+) + taurocholate => 7-oxo-taurodeoxycholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11936", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + trans-resveratrol", "d": []}, {"i": "EC:2.3.1.95", "l": "\"trihydroxystilbene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928576", "l": "RHOA:GTP binds ROCK, activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55236", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O = (9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982775", "l": "Growth hormone receptor dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30542", "l": "(R)-carnitinyl-CoA <=> (S)-carnitinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047990", "l": "hydroxyglutamate decarboxylase activity", "d": ["Catalysis of the reaction: 3-hydroxy-L-glutamate + H+ = 4-amino-3-hydroxybutanoate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390909", "l": "HRH2 binds hist (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141159", "l": "TNF-mediated dimerization of procaspase-8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030565", "l": "snRNA pseudouridylation guide activity", "d": ["Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770142", "l": "Formation of the Spliceosomal B complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201639", "l": "Caspase-mediated cleavage of GAS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14183", "l": "(3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20813", "l": "(3S)-citryl-CoA => acetyl-CoA + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73790", "l": "dimethylallyl diphosphate + tardioxopiperazine A <=> diphosphate + variecolorin L", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74834", "l": "UDP-alpha-D-glucuronate(out) + UDP-alpha-D-xylose(in) <=> UDP-alpha-D-glucuronate(in) + UDP-alpha-D-xylose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351936", "l": "Caspase-mediated cleavage of claspin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57899", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177926", "l": "Dephosphorylation of PAG by SHP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27905", "l": "caffeine + H2O + ubiquinone-0 <=> 1,3,7-trimethylurate + ubiquinol-0", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034903", "l": "endosulfan ether monooxygenase activity", "d": ["Catalysis of the reaction: endosulfan ether + O2 + 2 H+ + 2 e- = endosulfan hydroxyether + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.-.-", "l": "\"Acting on NADH or NADPH\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379464", "l": "COMT transfers Met to DOPAC to form HVA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730872", "l": "Activation of Calcineurin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9718020", "l": "PTGFR binds PTGFR agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-606326", "l": "HJURP:CENPA complex localizes to the centromere (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018826", "l": "RHOT2 hydrolyzes GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75862", "l": "Fall Back to Closed Pre-initiation Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40893", "l": "H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52811", "l": "adenosine in U6 snRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19094", "l": "2 H(+) + siroheme => 12,18-didecarboxysiroheme + 2 CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707594", "l": "Hemes bind LY96 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682388", "l": "Autophagosome maturation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35812", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol => (-)-medicarpin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16597", "l": "ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14245", "l": "ATP + H2O = AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818574", "l": "TASP1 cleaves KMT2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709179", "l": "DPP4 binds DPP4 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54718", "l": "H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15516", "l": "ATP + keto-D-tagatose <=> ADP + H(+) + keto-D-tagatose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851908", "l": "Activated MET binds GAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56208", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] = 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67077", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine => H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.44", "l": "\"(R)-dichlorprop dioxygenase (2-oxoglutarate)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684140", "l": "ATM phosphorylates RBBP8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53127", "l": "all-trans-lycopene <=> delta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51215", "l": "(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) <=> 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14498", "l": "A + pyridoxine => AH2 + isopyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669158", "l": "NF2 binds PAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63556", "l": "dynorphin A-(1-13) + H2O = dynorphin A-(1-12) + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008822", "l": "PPM1D dephosphorylates RUNX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.14", "l": "\"ABC-type aliphatic sulfonate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106357", "l": "glycerol-1-phosphate dehydrogenase [NAD+] activity", "d": ["Catalysis of the reaction: NAD+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADH."]}, {"i": "RHEA:21412", "l": "NAD(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68424", "l": "(3R)-3-hydroxy-10'-apo-beta-carotenal + O2 = (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56262", "l": "4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018688", "l": "DDT 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + O2 + 2 H+ + 2 e- = cis-2,3-dihydrodiol DDT. 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane is also known as DDT."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27939", "l": "(3R)-3-hydroxy-D-aspartate => glycine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45603", "l": "D-galactaro-1,4-lactone <=> 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015661", "l": "L-lysine efflux transmembrane transporter activity", "d": ["Enables the transfer of L-lysine from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0051020", "l": "GTPase binding", "d": ["Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.62", "l": "\"multiple inositol-polyphosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042561", "l": "alpha-amyrin synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = alpha-amyrin. This reaction is a cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into alpha-amyrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51007", "l": "a primary alcohol + 2 Fe(III)-[cytochrome cL] <=> an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424254", "l": "LDLR transports extracellular CR:atREs to cytosol  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72621", "l": "Ribosomal scanning  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784765", "l": "p-Y705-STAT3 dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47817", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56301", "l": "[thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein] => [thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46392", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875816", "l": "STAT3 binds activated MET receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34863", "l": "(Z)-2,3-didehydroadipyl-CoA + H2O = 3-hydroxyadipyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110152", "l": "RNA NAD-cap (NAD-forming) hydrolase activity", "d": ["Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H+ + NAD+."]}, {"i": "RHEA:60880", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67035", "l": "4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036174", "l": "butane monooxygenase activity", "d": ["Catalysis of the reaction: butane + O2 + NAD(P)H + H+ = butanol + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65508", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2 = H2O2 + NH4(+) + pre-mycofactocin", "d": []}, {"i": "EC:1.4.3.26", "l": "\"pre-mycofactocin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15676", "l": "acetoacetyl-CoA + H2O <=> acetoacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18842", "l": "(R)-glycerate + NADP(+) => 2-hydroxy-3-oxopropanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73990", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + discoidol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36131", "l": "(indol-3-yl)acetate + S-adenosyl-L-methionine = methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.278", "l": "\"indole-3-acetate O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625699", "l": "FOXO1 and NR3C1 bind TRIM63 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9669893", "l": "KIT binds type I TKIs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254291", "l": "ERBB4s80 binds STAT5A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46889", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + O2 => 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640195", "l": "RRAGA,B hydrolyzes GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38068", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA => 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373730", "l": "Neurofascin and NrCAM heterodimerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450550", "l": "PKCalpha phosphorylates HuR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.9", "l": "\"dTMP kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004473", "l": "malate dehydrogenase (decarboxylating) (NADP+) activity", "d": ["Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50674", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75060", "l": "chloride(out) + 2 hydrogencarbonate(in) + K(+)(in) => chloride(in) + 2 hydrogencarbonate(out) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50431", "l": "methanethiol + S-adenosyl-L-methionine <=> dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54566", "l": "a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+) => a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983077", "l": "STAT3 binds TSLP:IL7R:CRLF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014812", "l": "ROBOs bind keratan sulfate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59649", "l": "D-xylotriono-1,5-lactone + H2O => D-xylotrionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187261", "l": "COLEC12 (SCARA4) binds ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67301", "l": "(5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one => 3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64831", "l": "3-hydroxybenzyl alcohol + acetyl-CoA <=> 3-hydroxy-benzyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23945", "l": "(E)-coniferol + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-coniferol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62422", "l": "a fatty acid + CO2 + H2O => a (R)-2-hydroxy fatty acid + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58984", "l": "acrolein + H2O + O2 = acrylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352981", "l": "phosphoenolpyruvate + H2O <=> 2-phosphoglycerate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620828", "l": "FOXO1,FOXO3,(FOXO4) binds CCNG2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.24", "l": "\"nucleoside phosphoacylhydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9725206", "l": "IgE binds FCERI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22213", "l": "(2R,3R)-tartrate => (2R,3S)-tartrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53292", "l": "H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin = H(+) + N-carbamoyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74797", "l": "N-methyl-(R)-salsolinol(out) => N-methyl-(R)-salsolinol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1006143", "l": "CD46 binds C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41492", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980125", "l": "ITCH binds DTX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203893", "l": "Microprocessor complex cleaves pri-miRNA to pre-miRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75382", "l": "H2O + L-canavanine <=> L-homoserine + N-hydroxyguanidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2106614", "l": "Duplex miRNA is loaded into Argonaute (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31551", "l": "presqualene diphosphate = 15-cis-4,4'-diapophytoene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675417", "l": "PEBP1 binds activated RAF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62993", "l": "H2O + tetradecamide => NH4(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57041", "l": "aldehydo-D-apiose => D-apiofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73573", "l": "(E,E)-piperoyl-CoA + AMP + diphosphate => (E,E)-piperate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296326", "l": "HCAR1 binds LACT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097626", "l": "low-affinity L-arginine transmembrane transporter activity", "d": ["Enables the transfer of L-arginine from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209188", "l": "TAK1-binding protein TAB2 binds to TAK1 kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72901", "l": "proatranorin I + S-adenosyl-L-homocysteine => 4-O-demethylbarbatate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26282", "l": "Co-precorrin-5A + H2O => acetaldehyde + Co-precorrin-5B + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61067", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine <=> beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72937", "l": "(S)-lactate(in) + 2 Na(+)(in) => (S)-lactate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25839", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O <=> 5-deoxy-D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026907", "l": "GGT hydrolyses PCTR2 to PCTR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39355", "l": "(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0062080", "l": "inhibitory MHC class Ib receptor activity", "d": ["Combining with a MHC class Ib protein complex to mediate signaling that inhibits activation of a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56635", "l": "H2O + neryl diphosphate <=> 1,8-cineole + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45255", "l": "tetradecanoate(out) <=> tetradecanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51382", "l": "CoA + H(+) + N-(9Z-octadecanoyl)-dopamine => (9Z)-octadecenoyl-CoA + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662710", "l": "IL6 gene produces IL6 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61979", "l": "glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24486", "l": "H(+) + NADH + sulcatone => NAD(+) + sulcatol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332356", "l": "CAMK2 binds MAP3K7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362437", "l": "C-terminal Hh fragments are bound by lectins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36904", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37595", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25597", "l": "5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate", "d": []}, {"i": "EC:4.2.99.20", "l": "\"2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950741", "l": "IL12B:IL23A translocates from ER lumen to extracellular space (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1222491", "l": "Lactoferrin scavenges iron ions (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22960", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] = calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.88", "l": "\"isoflavone 3'-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140575", "l": "transmembrane monodehydroascorbate reductase activity", "d": ["Oxidation of monodehydroascorbate outside of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction."]}, {"i": "RHEA:66524", "l": "L-ascorbate(in) + monodehydro-L-ascorbate radical(out) = L-ascorbate(out) + monodehydro-L-ascorbate radical(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034797", "l": "fosfomycin 2-glutathione ligase activity", "d": ["Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + glutathione = hydrogen (1R,2R)-1-glutathio-2-hydroxypropylphosphonic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49133", "l": "an adenosine in tRNA + S-adenosyl-L-methionine => an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183055", "l": "Binding of CBL to EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18218", "l": "2-oxoglutarate + an alkane-alpha,omega-diamine => an omega-aminoaldehyde + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23640", "l": "1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 = CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate", "d": []}, {"i": "EC:1.14.17.4", "l": "\"aminocyclopropanecarboxylate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211239", "l": "Association of DFF40 with chromatin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58495", "l": "ATP + Fe(III)-enterobactin(out) + H2O <=> ADP + Fe(III)-enterobactin(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417927", "l": "P2Y2 receptor binds ATP and UTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655142", "l": "RCHY1 binds POLH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12822", "l": "2-deoxy-D-ribose 5-phosphate => acetaldehyde + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18827", "l": "[(1->6)-alpha-D-glucosyl](n+1) + D-fructose => [(1->6)-alpha-D-glucosyl](n) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74139", "l": "petunidin + UDP-alpha-D-glucose = petunidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42294", "l": "an acyl phosphate + holo-[ACP] => a fatty acyl-[ACP] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47683", "l": "D-galactosamine 6-phosphate + H2O <=> D-tagatopyranose 1-phosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003881", "l": "CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity", "d": ["Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53540", "l": "(13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O = (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782311", "l": "ADAT2:ADAT3 (hetADAT) deaminates adenosine-34 in tRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47514", "l": "isocholate + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45587", "l": "3-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29268", "l": "L-valine(in) + Na(+)(in) => L-valine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389523", "l": "BTLA interacts with HVEM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247847", "l": "WLS is endocytosed to the early endosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35247", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(in) + ATP + H2O = ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30616", "l": "15-cis-phytoene + 2 A => 2 AH2 + all-trans-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18414", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0070546", "l": "L-phenylalanine aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from L-phenylalanine to an acceptor, usually a 2-oxo acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40784", "l": "docosanoyl-CoA + H2O => CoA + docosanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67554", "l": "adenosine 3',5'-bisphosphate + cholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + cholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14798", "l": "2-dehydro-3-deoxy-D-gluconate + ATP => 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31747", "l": "3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) = 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.91", "l": "\"3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51127", "l": "uridine in snRNA <=> pseudouridine in snRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31790", "l": "H2O + tuberculosinyl diphosphate <=> (13R)-edaxadiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11240", "l": "ATP + thiamine diphosphate = ADP + thiamine triphosphate", "d": []}, {"i": "EC:2.7.4.15", "l": "\"thiamine-diphosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52035", "l": "H2O + L-isoleucine-(+)-7-isojasmonate <=> (+)-7-isojasmonate + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18147", "l": "ADP + beta-D-fructose 1-phosphate + H(+) => ATP + beta-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35843", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28038", "l": "[thioredoxin]-disulfide + dCDP + H2O = [thioredoxin]-dithiol + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19621", "l": "a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 3'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448702", "l": "Caspase-1 active tetramer formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31178", "l": "(2E)-2-methylpropenoyl-CoA + H2O <=> (S)-3-hydroxyisobutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0034068", "l": "aminoglycoside nucleotidyltransferase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + nucleotidylaminoglycoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705299", "l": "SARS-CoV-2 6 binds KPNA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23413", "l": "H2O + N-acetylputrescine => acetate + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473186", "l": "FSTL3 binds Activin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45328", "l": "7,8-dihydroneopterin = 7,8-dihydromonapterin", "d": []}, {"i": "EC:5.1.99.8", "l": "\"7,8-dihydroneopterin epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30617", "l": "2 AH2 + all-trans-zeta-carotene => 15-cis-phytoene + 2 A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.15", "l": "\"endo-polygalacturonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216045", "l": "Collagen type I binds integrin alpha11beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624668", "l": "CEBPA binds CDKN1A (p21) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170008", "l": "mRNA phosphatase activator activity", "d": ["Binds to and increases the activity of mRNA phosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858270", "l": "HILPDA binds lipid droplets (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007759", "l": "MSX2 binds RUNX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5138459", "l": "WNT5A:FZD4 is endocytosed (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58853", "l": "(6E)-8-oxogeraniol + NAD(+) => (6E)-8-oxogeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12661", "l": "(R)-carnitine + hexadecanoyl-CoA = CoA + O-hexadecanoyl-(R)-carnitine", "d": []}, {"i": "EC:2.3.1.21", "l": "\"carnitine O-palmitoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15712", "l": "kaempferol + UDP-alpha-D-galactose <=> H(+) + kaempferol 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72693", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) => 17beta-estradiol 17-O-(beta-D-glucuronate)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189406", "l": "4 PBGs bind to form HMB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082391", "l": "Trimerization of HSF1 in the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54288", "l": "ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9609921", "l": "SGTA binds Tail-anchored protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16191", "l": "CO2 + homogentisate => 3-(4-hydroxyphenyl)pyruvate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64715", "l": "1-propanol + NADP(+) <=> H(+) + NADPH + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000120", "l": "CBLIF binds RCbl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295632", "l": "PPA2A dephosphorylates SPRY2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035460", "l": "L-ascorbate 6-phosphate lactonase activity", "d": ["Catalysis of the reaction: L-ascorbate 6-phosphate + H2O = 3-keto-L-gulonate 6-phosphate."]}, {"i": "RHEA:28803", "l": "H2O + L-ascorbate 6-phosphate = 3-dehydro-L-gulonate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53345", "l": "5,6-dihydrouridine(20a) in tRNA + NADP(+) => H(+) + NADPH + uridine(20a) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35920", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose => H(+) + kanamycin D + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46383", "l": "7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59394", "l": "CoA + O-acetyl-L-seryl-[protein] => acetyl-CoA + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10806", "l": "(R)-allantoin => (S)-allantoin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.187403162058388", "identifiers": [{"i": "GO:0004540", "l": "RNA nuclease activity", "d": ["Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010872", "l": "SLIT2 binds Dystroglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10036", "l": "4-hydroxy-3-methoxy-benzenemethanol + O2 = H2O2 + vanillin", "d": []}, {"i": "EC:1.1.3.38", "l": "\"vanillyl-alcohol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50277", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58009", "l": "(20S)-ginsenoside F1 + UDP-alpha-D-glucose => (20S)-ginsenoside Rg1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615638", "l": "EGR2 and SOX10 bind the MBP gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43544", "l": "ATP + L-glutamate + tyramine = ADP + gamma-L-glutamyltyramine + H(+) + phosphate", "d": []}, {"i": "EC:6.3.4.24", "l": "\"tyramine--L-glutamate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63349", "l": "ATP + L-amino acyl-L-cysteinyl-[protein] => (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50119", "l": "eicosanoyl-CoA + taurine <=> CoA + H(+) + N-eicosanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102214", "l": "omega-hydroxy fatty acyl-CoA synthetase activity", "d": ["Catalysis of the reaction: coenzyme A + ATP + an omega-hydroxy fatty acid = diphosphoric acid + AMP + a omega-hydroxyacyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708275", "l": "PDE4A binds PDE4A inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38812", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046175", "l": "Further sulfation on galactose residues produces KSPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019810", "l": "putrescine binding", "d": ["Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848713", "l": "PTK6 binds BCAR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.159", "l": "\"theobromine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0140135", "l": "mechanosensitive monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a monoatomic cation by a channel that opens in response to a mechanical stress."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-352059", "l": "SLC6A15-mediated amino acid uptake (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69609", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin] => acetyl-CoA + N-terminal L-methionyl-[tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58881", "l": "4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727188", "l": "ATP4A:ATP4B binds PPIs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9669854", "l": "KIT binds type II TKIs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67145", "l": "2-oxoglutarate + jasmonate + O2 => (1R,2R)-12-hydroxyjasmonate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196753", "l": "2xPPCS ligates PPanK with Cys (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26343", "l": "H(+) + L-methionine + Se-methyl-L-selenocysteine => L-selenocysteine + S-methyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.154", "l": "\"fructan beta-(2,6)-fructosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12032", "l": "a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)", "d": []}, {"i": "EC:3.1.1.77", "l": "\"acyloxyacyl hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51412", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75038", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate <=> 1-hexadecanoyl-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63782", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55290", "l": "CoA + tetradecanyl tetradecanoate => tetradecan-1-ol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70185", "l": "alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose => 2 alpha-isomaltosyl-(1->4)-D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374909", "l": "Metabolism of Noradrenaline (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982778", "l": "Growth hormone binds the growth hormone receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75500", "l": "cholate(out) + n H(+)(out) => cholate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791235", "l": "GADD45A binds AURKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173631", "l": "Activation of C1s (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39353", "l": "(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38285", "l": "itaconyl-CoA + succinate => itaconate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993802", "l": "HLCS biotinylates PC:Mn2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55588", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base = a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655483", "l": "USP1 autocleavage (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018808", "l": "RAC3 binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44544", "l": "a fatty acid(out) + ATP + H2O = a fatty acid(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71403", "l": "2alpha-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] = 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68780", "l": "(2Z,6Z)-farnesyl diphosphate = alpha-humulene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41985", "l": "NAD(+) + propan-2-ol => acetone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16212", "l": "Co-precorrin-8X <=> cob(II)yrinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421835", "l": "trans-Golgi Network Vesicle Scission (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102172", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 + H+ <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033716", "l": "nucleoside oxidase (hydrogen peroxide-forming) activity", "d": ["Catalysis of the reactions: adenosine + 2 O2 = 9-riburonosyladenine + 2 hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36229", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870469", "l": "RGGT geranylgeranylates RAB proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682311", "l": "Defective ABCA12 does not transport lipids from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24059", "l": "a myo-inositol phosphate + H2O <=> myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5606996", "l": "Soluble PROCR binds activated protein C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17304", "l": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] <=> ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706330", "l": "Active FLT3 binds to SOCS6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211951", "l": "CYP1B1 4-hydroxylates EST17b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73171", "l": "adenosine 3',5'-bisphosphate(out) + NAD(+)(in) = adenosine 3',5'-bisphosphate(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940100", "l": "CDK1 phosphorylates VCPIP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9732629", "l": "PPARG binds PPARG agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-179421", "l": "Degradation of multiubiquitinated Nek2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088162", "l": "FOXM1 binds CDC25A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18062", "l": "5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran => methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21768", "l": "H2O + N-methyl-L-alanine + NADP(+) = H(+) + methylamine + NADPH + pyruvate", "d": []}, {"i": "EC:1.4.1.17", "l": "\"N-methylalanine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62460", "l": "3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] = 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.62", "l": "\"3,4-dihydroxybenzoate--[aryl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69978", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67775", "l": "a 5'-end 5'-monophospho-ribonucleoside-RNA + H2O <=> a 5'-end dephospho-ribonucleoside-RNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10502", "l": "3-ethylmalate + CoA + H(+) => butanoyl-CoA + glyoxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690740", "l": "CD22 binds B-cell receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35217", "l": "H(+) + phosphate + XMP => H2O + XDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3095889", "l": "MMACHC dealkylates RCbl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45007", "l": "(R)-carnitine + 2,6-dimethylheptanoyl-CoA <=> CoA + O-2,6-dimethylheptanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24949", "l": "3-hydroxy-3-methylglutarate + malonyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54258", "l": "(3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-histidyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821366", "l": "AKAP8L binds MLL2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696274", "l": "RND1 binds GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804229", "l": "JMY, TTC5 and EP300 bind (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41601", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28395", "l": "L-alanyl-L-glutamate => L-alanyl-D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662622", "l": "MT1X binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10012", "l": "(R)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2", "d": []}, {"i": "EC:1.5.3.6", "l": "\"(R)-6-hydroxynicotine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25702", "l": "N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4724291", "l": "Defective ALG6 does not add glucose to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39896", "l": "7-deoxyloganetate + UDP-alpha-D-glucose => 7-deoxyloganate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8960973", "l": "RLBP1:11cRAL dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625426", "l": "Retrograde IFT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54099", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111879", "l": "PIP2 hydrolysis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28096", "l": "di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate => di-trans,octa-cis-undecaprenyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215406", "l": "PRMT5 binds WDR77 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19023", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10863", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 <=> 2-(acetamidomethylene)succinate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701488", "l": "Active ALK phosphorylates JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33705", "l": "CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine => (4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637766", "l": "Binding of SHC1 to p-5Y-EGFRvIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.22", "l": "\"carbazole 1,9a-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18205", "l": "AH2 + O2 + progesterone = 11alpha-hydroxyprogesterone + A + H2O", "d": []}, {"i": "EC:1.14.99.14", "l": "\"progesterone 11alpha-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41812", "l": "(2E)-butenoyl-[ACP] + H(+) + NADPH = butanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.5.1.-", "l": "\"Carbon-halide lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034860", "l": "2-mercaptobenzothiazole desulfurase activity", "d": ["Catalysis of the reaction: 2-mercaptobenzothiazole + reduced acceptor = benzothiazole + hydrogen sulfide + oxidized acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72663", "l": "De novo formation of eIF2:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69697", "l": "menadiol + NAD(+) => H(+) + menadione + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37266", "l": "ATP + H2O + L-alanyl-L-aspartate(out) <=> ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190245", "l": "FGFR1b binds to FGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37481", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52595", "l": "deoxycholoyl-CoA + NAD(+) <=> 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44611", "l": "3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13350", "l": "jasmonate + S-adenosyl-L-methionine => methyl (-)-jasmonate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57934", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.39", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19317", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate", "d": []}, {"i": "EC:6.3.4.18", "l": "\"5-(carboxyamino)imidazole ribonucleotide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55084", "l": "(3R)-3-hydroxypentanoyl-CoA + H2O = (3R)-3-hydroxypentanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382553", "l": "ABCA7:Apo1A-mediated phospholipid efflux (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19113", "l": "(8Z,11Z,14Z)-heptadecatrienal + A + H2O = (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56157", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine => (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45500", "l": "phycocyanobilin-L-cysteinyl(84)-[allophycocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018111", "l": "methionine racemase activity", "d": ["Catalysis of the reaction: L-methionine = D-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75096", "l": "Docking of the TAP:EJC Complex with the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009072", "l": "STAT3 phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63388", "l": "2 A + Fe(II)-heme o + H2O = 2 AH2 + Fe(II)-heme a", "d": []}, {"i": "EC:1.17.99.9", "l": "\"heme a synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392749", "l": "Transport of L1 into endosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374173", "l": "AGT(34-41) binds to AGTR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73332", "l": "(2R,3S)-piscidate + (E)-feruloyl-CoA => cimicifugate E + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141439", "l": "Release of activated MAD2 from kinetochores (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201611", "l": "Caspase-mediated cleavage of Rock-1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130504", "l": "Cleavage of lip22 to lip10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34844", "l": "7,8-dihydromonapterin 3'-triphosphate + 3 H2O => 7,8-dihydromonapterin + 2 H(+) + 3 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61081", "l": "(+)-minovincinine + acetyl-CoA => (+)-echitovenine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12005", "l": "indoxyl + UDP-alpha-D-glucose => H(+) + indican + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13538", "l": "(2R)-3-phosphoglycerate + GDP-alpha-D-mannose => 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45558", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine => H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29843", "l": "ATP + CoA + propanoate = ADP + phosphate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20917", "l": "L-cysteine + sulfite => hydrogen sulfide + L-cysteate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016844", "l": "strictosidine synthase activity", "d": ["Catalysis of the reaction: 3alpha(S)-strictosidine + H2O = secologanin + tryptamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75054", "l": "chenodeoxycholate(out) <=> chenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30307", "l": "7-methylxanthine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74081", "l": "menaquinol-4 + NAD(+) => H(+) + menaquinone-4 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66471", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O <=> (17E)-cheilanthenediol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016964", "l": "alpha-2 macroglobulin receptor activity", "d": ["Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64062", "l": "1-phenyl-1,2-propanedione + H(+) + NADH => (S)-phenylacetylcarbinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46655", "l": "epitestosterone + H(+) + NADPH <=> 5beta-dihydroepitestosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46050", "l": "alpha-D-galactosamine 1-phosphate => D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63115", "l": "A + ascofuranol <=> AH2 + ascofuranone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626817", "l": "PKC phosphorylates NCF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26433", "l": "(+)-copalyl diphosphate + H2O <=> diphosphate + phyllocladan-16alpha-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928617", "l": "EPHB2 binds KALRN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47726", "l": "5-oxo-L-proline + L-cysteinylglycine => glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46478", "l": "4alpha-formylzymosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63642", "l": "2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => (R)-N(6)-lipoyl-L-lysyl-[protein] + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0061598", "l": "molybdopterin adenylyltransferase activity", "d": ["Catalysis of the reaction ATP + molybdopterin = diphosphate + adenylyl-molybdopterin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56184", "l": "globoside Gb4Cer + UDP-alpha-D-galactose = globoside NOR1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11140", "l": "alpha-D-mannose 1-phosphate = D-mannose 6-phosphate", "d": []}, {"i": "EC:5.4.2.8", "l": "\"phosphomannomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61494", "l": "an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+) => a sphingoid base + an ultra-long-chain fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56505", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39585", "l": "(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62590", "l": "4-hydroxybenzyl alcohol + CO2 => 2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64748", "l": "H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine = 2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43230", "l": "H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine => L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35384", "l": "precorrin-6B + S-adenosyl-L-methionine => CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10770", "l": "(4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate => (2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48782", "l": "ADP + H(+) + L-erythrulose 1-phosphate => ATP + L-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12893", "l": "prostaglandin H2 = prostaglandin E2", "d": []}, {"i": "EC:5.3.99.3", "l": "\"prostaglandin-E synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.86", "l": "\"N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22930", "l": "4-aminobutanoyl-CoA + acetate => 4-acetamidobutanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17259", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine => O2 + reduced [NADPH--hemoprotein reductase] + vinorine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11029", "l": "ATP + D-mannose => ADP + D-mannose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31531", "l": "2-oxoglutarate + L-arginine + O2 = CO2 + N(omega)-hydroxy-L-arginine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016232", "l": "HNK-1 sulfotransferase activity", "d": ["Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R)."]}, {"i": "REACT:R-HSA-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388830", "l": "PI3K binds ICOS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33264", "l": "L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193695", "l": "IRAK interacts with TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391913", "l": "FPR2 binds FPR2 ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848316", "l": "IL36 binds IL1RL2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70502", "l": "D-galactose(out) + 2 Na(+)(out) <=> D-galactose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52154", "l": "(Z)-indolylmethyl desulfoglucosinolate + UDP => (Z)-2-(indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54444", "l": "a (2R,3S,4S)-leucoanthocyanidin + NADP(+) = a (2R,3R)-dihydroflavonol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19373", "l": "H2O + L-saccharopine + NADP(+) = 2-oxoglutarate + H(+) + L-lysine + NADPH", "d": []}, {"i": "EC:1.5.1.8", "l": "\"saccharopine dehydrogenase (NADP(+), L-lysine-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28575", "l": "H(+)(in) + sulfate(in) => H(+)(out) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64256", "l": "dodecanoyl-CoA + glycine = CoA + H(+) + N-dodecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928641", "l": "PAK binds RAC and bPIX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19966", "l": "S,S-dimethyl-beta-propiothetin => acrylate + dimethyl sulfide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928607", "l": "p-EPHs bind VAV2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14246", "l": "ATP + H2O => AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667619", "l": "AVPR1A,B,2 bind atosiban (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16190", "l": "3-(4-hydroxyphenyl)pyruvate + O2 => CO2 + homogentisate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21276", "l": "D-arabinitol + NADP(+) = D-xylulose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2002428", "l": "Removal of fibrillar collagen N-propeptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373736", "l": "Shootin-1 links L1 and retrograde actin flow (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74904", "l": "(2E)-2-butenoate + ATP + H(+) => (2E)-but-2-enoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72954", "l": "butanoate(out) + 2 Na(+)(out) <=> butanoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247844", "l": "WNT ligands traffic to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43932", "l": "3beta-hydroxyandrost-5-en-17-one + NAD(+) = androst-5-ene-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65713", "l": "alpha-D-glucose 1-phosphate + GDP-beta-L-galactose => beta-L-galactose 1-phosphate + GDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33937", "l": "H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide => 2 N(omega)-hydroxy-L-arginine + NADH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15782", "l": "L-tyrosine => 3-amino-3-(4-hydroxyphenyl)propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0051219", "l": "phosphoprotein binding", "d": ["Binding to a phosphorylated protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22896", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)", "d": []}, {"i": "EC:2.3.1.86", "l": "\"fatty-acyl-CoA synthase system\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42026", "l": "3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH => 3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72907", "l": "D-mannose(out) + Na(+)(out) = D-mannose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327746", "l": "FN1 aggregation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10220", "l": "ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)", "d": []}, {"i": "EC:6.1.1.1", "l": "\"tyrosine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9708275", "l": "PDE4A binds PDE4A inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24042", "l": "H(+) + NADP(+) + 2 reduced [cytochrome P450] => NADPH + 2 oxidized [cytochrome P450]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2984226", "l": "PLK1 phosphorylates NEK9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60865", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54005", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698930", "l": "HCMV C Nucleocapsid Translocation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16628", "l": "acetyl-CoA + hydrogen sulfide <=> CoA + thioacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18054", "l": "H2O + paraoxon => 4-nitrophenol + diethylphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18606", "l": "1-amino-1-deoxy-scyllo-inositol + ATP => 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33434", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate <=> (3E)-2-oxohex-3-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202714", "l": "CD58 binds CD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44181", "l": "2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51043", "l": "indole-3-pyruvate imine dimer <=> chromopyrrolate + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75673", "l": "14,15-epoxy-12-hydroxy-(10E,17Z)-eicosadienoate => 12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424485", "l": "Release of p-PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13032", "l": "H2O + N-acetyl-D-glucosamine + O2 <=> H(+) + H2O2 + N-acetyl-D-glucosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749609", "l": "BCHE hydrolyzes ASA- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38253", "l": "CoA + hexadecanyl octadecanoate => hexadecan-1-ol + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9718360", "l": "GNRHR binds GNRHR peptide agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140806", "l": "SERPINC1 binds SERPINC1 activators (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30203", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate = 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086083", "l": "SUMOylation of ING2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29946", "l": "2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) <=> 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26501", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose <=> delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62265", "l": "hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) => hydrogencarbonate(in) + selenite(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5681987", "l": "LC3 is cleaved by ATG4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33475", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine = a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936563", "l": "ISGylation of DDX58 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52575", "l": "butanoyl-CoA + NAD(+) <=> (2E)-butenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018136", "l": "peptidyl-thiazoline dehydrogenase activity", "d": ["Catalysis of the reduction of a peptide-linked thiazoline to thiazole."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37996", "l": "all-trans-nonaprenyl diphosphate + H(+) + homogentisate => 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49386", "l": "(12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33078", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine <=> 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47795", "l": "cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50830", "l": "(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0016731", "l": "oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP."]}, {"i": "EC:1.18.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035472", "l": "choriogonadotropin hormone receptor activity", "d": ["Combining with the choriogonadotropin hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "56.100061334875598", "identifiers": [{"i": "GO:0016829", "l": "lyase activity", "d": ["Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653974", "l": "Ragulator binds Rag dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72246", "l": "catechol + S-adenosyl-L-methionine <=> guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46861", "l": "3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate => 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791228", "l": "45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004569", "l": "glycoprotein endo-alpha-1,2-mannosidase activity", "d": ["Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32668", "l": "coenzyme M + methanethiol => H(+) + hydrogen sulfide + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.95", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12432", "l": "L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine", "d": []}, {"i": "EC:2.3.2.10", "l": "\"UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52926", "l": "16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42466", "l": "2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+) => biphenyl-2,2',3-triol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2530445", "l": "CD59 inhibits MAC formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33507", "l": "sphing-4-enine 1-phosphate = (2E)-hexadecenal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9717841", "l": "holo-FDPS dimer binds NBPs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36336", "l": "D-glucuronate + H2O + NAD(+) => D-glucarate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31609", "l": "all-trans-lycopene + H2O => rhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41625", "l": "3-sulfinopropanoyl-CoA + H2O => H(+) + propanoyl-CoA + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74703", "l": "(3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + O2 + reduced [NADPH--hemoprotein reductase] = 5-dehydro-6-demethoxyfumagillol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56762", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29796", "l": "ATP(in) + H2O(in) + Zn(2+)(out) => ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63610", "l": "apelin-16 + L-phenylalanine => apelin-17 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9621179", "l": "Cinaciguat binds sGC:NO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49808", "l": "a quinone + butan-1-ol = a quinol + butanal", "d": []}, {"i": "EC:1.1.5.11", "l": "\"1-butanol dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451033", "l": "(S)-Malate <=> Fumarate + H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418456", "l": "cGMP is degraded by PDEs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.148", "l": "\"lycopaoctaene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34154", "l": "3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine <=> 2-deoxystreptamine + 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806392", "l": "TP53 stimulates MLH1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341294", "l": "Superoxide reduces cytochrome c (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222342", "l": "Hydroperoxyl enters the bacterium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9656947", "l": "OGG1beta translocates to mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42676", "l": "L-cysteine + L-histidine + O2 = H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide", "d": []}, {"i": "EC:1.14.99.52", "l": "\"L-cysteinyl-L-histidinylsulfoxide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6795473", "l": "PDPK1 phosphorylates SGK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38938", "l": "cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31083", "l": "H2O + N-acetyl-D-muramoyl-L-alanine = L-alanine + N-acetyl-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.122", "l": "\"(S)-8-oxocitronellyl enol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551648", "l": "SUMOylation of TDG with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216133", "l": "Dissociation of CI from COS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044604", "l": "ABC-type phytochelatin transporter activity", "d": ["Enables the directed movement of a phytochelatin from one side of a membrane to the other. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3769397", "l": "SOST binds LRP5/6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654625", "l": "Activated FGFR3 binds SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13386", "l": "3-oxododecanoate + H(+) => 2-undecanone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72294", "l": "2,3-dimethylsuccinate(out) + 3 Na(+)(out) <=> 2,3-dimethylsuccinate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15552", "l": "S-methyl-5-thio-D-ribulose 1-phosphate <=> 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30080", "l": "ATP + CoA + crotonobetaine => AMP + crotonobetainyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37165", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110322", "l": "Formation of Pol zeta complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24557", "l": "5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) => 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031278", "l": "alpha-1,2-galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34855", "l": "2 H2O + iminodiacetonitrile = N-(cyanomethyl)glycine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14833", "l": "(R)-mevalonate + CoA + 2 NAD(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH", "d": []}, {"i": "EC:1.1.1.88", "l": "\"hydroxymethylglutaryl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69388", "l": "(S)-2-ureidoglycine + carbamoyl phosphate = allantoate + H(+) + phosphate", "d": []}, {"i": "EC:2.1.3.16", "l": "\"ureidoglycine carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67131", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH <=> (1R,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28469", "l": "pyridoxamine(in) <=> pyridoxamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40257", "l": "(3R)-hydroxyhexadecanedioyl-CoA => (2E)-hexadecenedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48279", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11010", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate => a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75019", "l": "1,2,3-tri-(10Z)-heptadecenoylglycerol + 9-hydroxy-octadecanoate = 9-(10Z-heptadecenoyloxy)-octadecanoate + di-(10Z)-heptadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37377", "l": "1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24849", "l": "3-dehydroshikimate => 3,4-dihydroxybenzoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.179", "l": "\"gellan tetrasaccharide unsaturated glucuronosyl hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58398", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin] => 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31626", "l": "L-olivosyl-oleandolide + S-adenosyl-L-methionine <=> H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264435", "l": "Dissociation of the COP1-p53 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.256", "l": "\"fluoren-9-ol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191299", "l": "Squalene is oxidized to its epoxide (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64558", "l": "8-epi-ilicicolin H => 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0070853", "l": "myosin VI binding", "d": ["Binding to a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051371", "l": "muscle alpha-actinin binding", "d": ["Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350651", "l": "Caspase-mediated cleavage of MASK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0003779", "l": "actin binding", "d": ["Binding to monomeric or multimeric forms of actin, including actin filaments."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11229", "l": "(2S)-flavan-4-ol + NADP(+) => (2S)-flavanone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48361", "l": "a 1,2-saturated fatty acid + H2O2 => a 2-hydroxy fatty acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53049", "l": "2-hydroxyestrone + UDP-alpha-D-glucuronate => 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20980", "l": "2 bilirubin IXalpha + O2 = 2 biliverdin IXalpha + 2 H2O", "d": []}, {"i": "EC:1.3.3.5", "l": "\"bilirubin oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41639", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O <=> 1-O-(1Z-alkenyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432164", "l": "Ca2+ influx into the post-synaptic cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44586", "l": "(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol) => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0048531", "l": "beta-1,3-galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39958", "l": "(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39554", "l": "(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH <=> (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65086", "l": "aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.52", "l": "\"[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.18", "l": "\"meprin A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379992", "l": "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.27", "l": "\"D-galactarolactone cycloisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102780", "l": "sitosterol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + sitosterol + O2 + NADPH <=> (22alpha)-hydroxy-sitosterol + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28581", "l": "Co(2+)(in) <=> Co(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11070", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose => (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388811", "l": "CD28 homodimer binds B7-1 homodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48774", "l": "3-deacetyl-3-vinylbacteriochlorophyllide a + H2O => 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34079", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+) = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693001", "l": "NAT8,8B acetylate BACE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624954", "l": "INPP5E translocates to the primary cilium (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2855047", "l": "Hydrolysis of internal thioester in C4b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848596", "l": "PTK6 binds PXN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23569", "l": "(2E)-decenoyl-[ACP] => (3Z)-decenoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19171", "l": "NH4(+) + pyruvate => L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38674", "l": "sphinganine 1-phosphate(in) <=> sphinganine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168886", "l": "Hemopexin binds Hemes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51934", "l": "2 Fe(II)-[cytochrome c3] + thiosulfate => 2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65551", "l": "ganglioside Fuc-GM1 + H2O <=> alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75957", "l": "CO2 + formaldehyde + oripavine + succinate => 2-oxoglutarate + O2 + thebaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35368", "l": "(2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH => isoheptadecanoyl-coA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47200", "l": "(24S)-7alpha-dihydroxycholesterol + NAD(+) = (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73545", "l": "dCDP(in) + UTP(out) => dCDP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45769", "l": "gamma-L-glutamyl-L-alaninol + H2O => L-alaninol + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25393", "l": "cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH => (3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62553", "l": "beta-D-glucosylceramide + UDP-alpha-D-galactose => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43413", "l": "a D-galactosylceramide + H2O => an N-acyl-sphingoid base + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65033", "l": "3 a quinone + protoporphyrinogen IX => 3 a quinol + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45745", "l": "(6S)-5,6,7,8-tetrahydropteroate + NAD(+) => 7,8-dihydropteroate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627775", "l": "Autophosphorylation of PAK1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16645", "l": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate", "d": []}, {"i": "EC:3.1.2.2", "l": "\"palmitoyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18436", "l": "cyclohexylamine + H2O + O2 <=> cyclohexanone + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67199", "l": "H2O + N-acetylserotonin <=> acetate + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9692738", "l": "HRH2 binds HRH2 antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36705", "l": "(3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+) => (2S,5S)-5-carboxymethylproline + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204850", "l": "Interaction of Tie2 and Dok-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64408", "l": "2 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) = 2 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25762", "l": "ent-copalyl diphosphate <=> diphosphate + ent-isokaurene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661230", "l": "MT1A binds arsenic (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43401", "l": "N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39485", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+) => 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002428", "l": "Removal of fibrillar collagen N-propeptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22353", "l": "H(+) + L-lysine => cadaverine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1445144", "l": "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24416", "l": "2,4'-dihydroxyacetophenone + O2 = 4-hydroxybenzoate + formate + 2 H(+)", "d": []}, {"i": "EC:1.13.11.41", "l": "\"2,4'-dihydroxyacetophenone dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72208", "l": "chloride(out) + 2 hydrogencarbonate(in) => chloride(in) + 2 hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130731", "l": "Formation of COPII vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53946", "l": "(2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH => 2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411402", "l": "Activation of NLK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036290", "l": "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to heparan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875531", "l": "MET binds TNS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37734", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74757", "l": "3,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine => kaempferide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31358", "l": "dimethyl sulfide + H(+) + NADH + O2 <=> formaldehyde + H2O + methanethiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018733", "l": "3,4-dihydrocoumarin hydrolase activity", "d": ["Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209376", "l": "SPN27A binds to and inhibits EA protease activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60677", "l": "(S)-(-)-citronellol + NAD(+) => (S)-(-)-citronellal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.35", "l": "\"barrierpepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389083", "l": "Autophosphorylation of PDGF alpha receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685011", "l": "ATR activation at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726949", "l": "PTGIR binds PTGIR agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73364", "l": "beta-alanyl-[peptidyl-carrier protein] + dopamine => beta-alanyl-dopamine + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0098808", "l": "mRNA cap binding", "d": ["Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an mRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028724", "l": "AMOT proteins bind YAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70084", "l": "hydroxyclavatol => H2O + o-quinone methide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45379", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68882", "l": "AMP + diphosphate + NADP(+) + salicylaldehyde => ATP + H(+) + NADPH + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60457", "l": "ATP + UTP => 3',3'-cUAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48187", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033407", "l": "UCA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UCA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802922", "l": "Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210444", "l": "L-Glutamate loading of synaptic vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419645", "l": "Dimerization of LIMK1 by Hsp90 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20738", "l": "(2S)-2-amino-3-oxobutanoate + CoA => acetyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28365", "l": "dGTP + H2O <=> dGMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012556", "l": "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57969", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34339", "l": "(22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5252133", "l": "ATP6AP1 binds V-ATPase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008914", "l": "leucyl-tRNA--protein transferase activity", "d": ["Catalysis of the reaction: L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H+ + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu). Can also transfer the leucyl residue on an N-terminal L-lysyl residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088130", "l": "PLK1 binds FOXM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019146", "l": "arabinose-5-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-arabinose 5-phosphate = D-ribulose 5-phosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31352", "l": "lupan-3beta,20-diol => (S)-2,3-epoxysqualene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26425", "l": "3'-phosphoadenylyl sulfate + thyroxine <=> adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981353", "l": "RASA1 stimulates RAS GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41602", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16473", "l": "cyclohexane-1,3-dione + H2O = 5-oxohexanoate + H(+)", "d": []}, {"i": "EC:3.7.1.10", "l": "\"cyclohexane-1,3-dione hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351341", "l": "Exocytosis of Proactivator polypeptide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453200", "l": "SYK autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39941", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380930", "l": "Phosphorylated AMPK binds AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53036", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29488", "l": "(2E,6E)-farnesyl diphosphate => cis-muurola-3,5-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299359", "l": "Activation of TALK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1980125", "l": "ITCH binds DTX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27994", "l": "H2O + xanthosine = D-ribose + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66717", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate => (2S)-3-sulfolactaldehyde + D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67780", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46293", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+) => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19352", "l": "(R)-4-dehydropantoate + H2O + NAD(+) <=> (R)-3,3-dimethylmalate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20138", "l": "10-deacetylbaccatin III + acetyl-CoA => baccatin III + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.-", "l": "\"Hydroxylases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052929", "l": "ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity", "d": ["Catalysis of the reaction: a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.6", "l": "\"beta-ureidopropionase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40003", "l": "ent-copalyl diphosphate = (Z)-biformene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043822", "l": "ribonuclease M5 activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34882", "l": "2 H2O + methyl 3-cyano-2-phenylpropanoate <=> 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28449", "l": "1-deoxy-D-xylulose(in) <=> 1-deoxy-D-xylulose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2995330", "l": "COX10 transforms heme to heme O (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5226999", "l": "ADD1:ADD3 binds DMTN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66078", "l": "H2O + kynurenate + L-2-aminopentanoate => 2-oxopentanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22107", "l": "2-oxoglutarate + nicotianamine <=> 3''-deamino-3''-oxonicotianamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42287", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8934446", "l": "Activated PKC phosphorylates SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72276", "l": "oxalate(in) + sulfate(out) => oxalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161293", "l": "Tropoelastin forms aggregate globules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-688137", "l": "RIP2 is K63 polyubiquitinated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54396", "l": "1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35330", "l": "eicosanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxodocosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56186", "l": "globoside NOR1 + H(+) + UDP => globoside Gb4Cer + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018708", "l": "thiol S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358790", "l": "RNF41 ubiquitinates ERBB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65758", "l": "(2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] => 2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199910", "l": "MSK1 activates ATF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420724", "l": "CASR binds Ca2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050630", "l": "(iso)eugenol O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683746", "l": "Protein 3a forms a homotetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867047", "l": "PTPN3 dephosphorylates EPS15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61117", "l": "(2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase] => (2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022073", "l": "Procollagen triple helix formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48365", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64821", "l": "2-phenylacetamide + H2O => 2-phenylacetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29660", "l": "O-acetyl-L-serine(in) => O-acetyl-L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68439", "l": "(3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2 <=> (3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17636", "l": "a beta-D-glucuronoside + H2O <=> an alcohol + D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.74456172809515", "identifiers": [{"i": "GO:0022824", "l": "transmitter-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847977", "l": "FRK phosphorylates PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806610", "l": "Keratin filament formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640480", "l": "E2 enzyme UBE2N:UBE2V1 binds ubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709454", "l": "EPOR binds EPOR agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17927", "l": "H(+) + L-arabinono-1,4-lactone + NADH => alpha-L-arabinopyanose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51938", "l": "glutathione disulfide + hydroquinone => 2-(glutathione-S-yl)-hydroquinone + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157640", "l": "NEXT2 is cleaved to produce NICD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65884", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine = H2O + L-glutamate + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140062", "l": "5-formylcytosine dioxygenase activity", "d": ["Catalysis of the reaction: 5-formylcytosine+ 2-oxoglutarate + O2 = 5-carboxylcytosine + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9620103", "l": "ALDH2 transforms GTN to NO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873919", "l": "Phosphorylation of JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805122", "l": "AURKB binds TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70314", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39369", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+) => (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18290", "l": "(S,S)-tartrate => H2O + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944240", "l": "Association of procollagen type III (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72612", "l": "H(+)(out) + L-alanyl-L-lysine(out) => H(+)(in) + L-alanyl-L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45611", "l": "H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622310", "l": "Activated NOD1 oligomerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28756", "l": "a ubiquinone + sn-glycerol 3-phosphate => a ubiquinol + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047247", "l": "luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP-alpha-D-glucuronate = H+ + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] 4'-O-beta-D-glucosiduronate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695415", "l": "glycosylated-ACE2 binds ACE2 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198621", "l": "AKT phosphorylates caspase-9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69528", "l": "chorismate + H2O + 2 L-glutamine = 4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+)", "d": []}, {"i": "EC:2.6.1.123", "l": "\"4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52751", "l": "alpha-isomaltosyl-(1->3)-isomaltose + H2O <=> 2 isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.535054500181104", "identifiers": [{"i": "GO:0035173", "l": "histone kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.8", "l": "\"protein-secreting ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25815", "l": "H2O + N(1)-acetylspermidine + O2 <=> 3-acetamidopropanal + H2O2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65734", "l": "CO2 + H(+) + heptanal + succinate + sulfate => 2-oxoglutarate + heptyl sulfate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72697", "l": "Start codon recognition (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68070", "l": "a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863471", "l": "LDLR is bound by DAB2 and ARH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060703", "l": "deoxyribonuclease inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of deoxyribonuclease."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74810", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37277", "l": "L-alanine + L-glutamine => H2O + L-alanyl-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28723", "l": "(S)-allantoin(in) + H(+)(in) = (S)-allantoin(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32659", "l": "(6E)-8-hydroxygeraniol + 2 NADP(+) = (6E)-8-oxogeranial + 2 H(+) + 2 NADPH", "d": []}, {"i": "EC:1.1.1.324", "l": "\"8-hydroxygeraniol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35573", "l": "(1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975040", "l": "KRAB-ZNF / KAP Interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114440", "l": "Dissociation of DIABLO:XIAP from the apoptosome complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64729", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12535", "l": "coenzyme B + methyl-coenzyme M <=> coenzyme M-coenzyme B heterodisulfide + methane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014294", "l": "RAC2 binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48713", "l": "2 Fe(2+) + 2 H(+) + H2O2 => 2 Fe(3+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24176", "l": "[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:2.8.1.4", "l": "\"tRNA uracil 4-sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202969", "l": "Caspase mediated cleavage of beta-catenin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41130", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24415", "l": "4-(hydroxymethyl)benzenesulfonate + NAD(+) <=> 4-formylbenzenesulfonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103106", "l": "brassinolide 23-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: brassinolide + UDP-alpha-D-glucose <=> brassinolide-23-O-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15101", "l": "H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine", "d": []}, {"i": "EC:4.1.1.20", "l": "\"diaminopimelate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602466", "l": "Activation of MT-MMPs by FURIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62875", "l": "(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2 <=> H2O + NADP(+) + semiviriditoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74245", "l": "H(+) + L-alanine + tRNA(Pro) => H2O + L-alanyl-tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14653", "l": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)", "d": []}, {"i": "EC:3.1.4.17", "l": "\"3',5'-cyclic-nucleotide phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74677", "l": "2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaeol => AH2 + archaeol + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050592", "l": "4-hydroxyphenylacetaldehyde oxime monooxygenase activity", "d": ["Catalysis of the reaction: (Z)-(4-hydroxyphenyl)acetaldehyde oxime + H+ + NADPH + O2 = (S)-4-hydroxymandelonitrile + 2 H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0046583", "l": "monoatomic cation efflux transmembrane transporter activity", "d": ["Enables the transfer of a cation or cations from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015529", "l": "raffinose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: raffinose(out) + H+(out) = raffinose(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730843", "l": "Phosphorylation of LAT by p-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684030", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61078", "l": "(-)-echitovenine + CoA => (-)-minovincinine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49002", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+) => aurachin C + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24959", "l": "H2O + N-acetyl-beta-D-muramate 6-phosphate <=> (R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31943", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35033", "l": "L-serine(out) => L-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928646", "l": "EPHAs bind EFNAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008663", "l": "2',3'-cyclic-nucleotide 2'-phosphodiesterase activity", "d": ["Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.17", "l": "\"deoxyribodipyrimidine endonucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67651", "l": "dATP + H2O <=> 2'-deoxyadenosine + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66964", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose = alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.379", "l": "\"GDP-Man:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706393", "l": "RHOBTB3 binds ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045301", "l": "tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity", "d": ["Catalysis of the reaction: tRNA-(2-methylthio-N-6-isopentenyl adenosine) = tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine) + O2. 2-methylthio-N-6-isopentenyl adenosine is also known as ms2i6A; 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine is also known as ms2io6A and 2-methylthio-cis-ribozeatin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610726", "l": "The IFT-A complex recruits TULP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14936", "l": "H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] <=> N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480520", "l": "Expression of SALL4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209253", "l": "Autophosphorylated FU phosphorylates COS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30297", "l": "GDP + H(+) + phosphoenolpyruvate => GTP + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52680", "l": "acetyl-CoA + L-alpha-phenylglycine = CoA + H(+) + N-acetyl-L-alpha-phenylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215144", "l": "TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693125", "l": "RHOF binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10129", "l": "all-trans-violaxanthin => all-trans-neoxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71895", "l": "dGTP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0019212", "l": "phosphatase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a phosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30489", "l": "(1E,2S)-2-methylbutanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51062", "l": "AH2 + androsta-1,4-diene-3,17-dione => 5alpha-androst-1-ene-3,17-dione + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177930", "l": "GAB1 phosphorylation by EGFR kinase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51253", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37992", "l": "delta-tocopherol + S-adenosyl-L-methionine => beta-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10350", "l": "ADP + H(+) + L-glutamate + phosphate => 5-oxo-L-proline + ATP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45030", "l": "2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein] => (2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856157", "l": "LAG3 (CD233) binds MHC II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63138", "l": "cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-adenosylglutathione => adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41447", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate + O2 <=> glycine + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11168", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) = 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.259", "l": "\"3-hydroxypimeloyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61347", "l": "H2O + L-serine + O2 <=> 3-hydroxypyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69074", "l": "Formation of Processive Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53817", "l": "hydrogen sulfide + O-succinyl-L-serine => L-cysteine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69988", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + NADP(+) => (22S)-22-hydroxycampest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050414", "l": "formimidoylaspartate deiminase activity", "d": ["Catalysis of the reaction: N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77081", "l": "Formation of the CE:GMP intermediate complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20391", "l": "(2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+) => (2R,3R)-dihydroquercetin + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75172", "l": "Formation of RAD50:MRE11 complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35865", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30527", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = ADP + ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57351", "l": "3-hydroxy-4-methyl-L-kynurenine + H2O <=> 3-hydroxy-4-methylanthranilate + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17202", "l": "2-dehydro-3-deoxy-L-arabinonate => 2,5-dioxopentanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68725", "l": "26-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 26-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350168", "l": "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70573", "l": "argininosuccinate <=> fumarate + arginine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75891", "l": "Abortive Initiation After Second Transition (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42192", "l": "(9Z)-pentadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-pentadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32962", "l": "H2O + L-isoleucine + NAD(+) <=> (S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43567", "l": "4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine <=> [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54218", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O => 2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64090", "l": "3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O => acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-517705", "l": "p-S318,221-HuR binds mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211482", "l": "HNF1A-dependent synthesis of FOXA3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26463", "l": "6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine => 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080176", "l": "xyloglucan 1,6-alpha-xylosidase activity", "d": ["Catalysis of the hydrolysis of xyloglucan side chains so as to remove unsubstituted D-xylose residues attached to the glucose located at the non-reducing terminus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30635", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}, {"i": "EC:2.4.1.267", "l": "\"dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49600", "l": "ATP + CoA + octanedioate = AMP + diphosphate + octanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70655", "l": "L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30473", "l": "(1S,5S,6S)-alpha-bergamotene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675417", "l": "PEBP1 binds activated RAF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617182", "l": "PRKACA phosphorylates PLN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42230", "l": "AH2 + estrone => 17beta-estradiol + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72691", "l": "Formation of the 43S pre-initiation complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28439", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + tetradecanoyl-[ACP] => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41824", "l": "3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28780", "l": "4-hydroxy-L-threonine => glycine + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41560", "l": "(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 = (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.15", "l": "\"(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5622134", "l": "CRABP1 binds atRA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26177", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine => 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019964", "l": "type II interferon binding", "d": ["Binding to type II interferon, also known as interferon-gamma."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374899", "l": "Release of noradrenaline  at the synapse (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047584", "l": "4-oxalmesaconate hydratase activity", "d": ["Catalysis of the reaction: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38223", "l": "(9Z)-octadecenoyl-CoA + decan-1-ol = 1-O-decyl-(9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63188", "l": "3,4-dihydroxybenzaldehyde + AH2 + tyramine = A + H2O + norbelladine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28467", "l": "pyridoxamine(in) => pyridoxamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68990", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71303", "l": "chloride(out) + L-methionine(out) + 2 Na(+)(out) = chloride(in) + L-methionine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23202", "l": "formaldehyde + H2O2 + L-lysine => H2O + N(6)-methyl-L-lysine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676257", "l": "Formation of the SET1A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21800", "l": "all-trans-antheraxanthin + L-ascorbate = all-trans-zeaxanthin + H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380176", "l": "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944255", "l": "Association of procollagen type VII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139941", "l": "Binding of IP3 to IP3 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64438", "l": "glycylglycyl-L-isoleucine(in) + H(+)(in) => glycylglycyl-L-isoleucine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42703", "l": "6-carboxyhexanoyl-[ACP] methyl ester + H2O <=> 6-carboxyhexanoyl-[ACP] + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.30", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047988", "l": "hydroxyacid-oxoacid transhydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24294", "l": "CoA + H(+) + N-acetyl-L-glutamate => acetyl-CoA + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15576", "l": "N-acetylserotonin + S-adenosyl-L-methionine <=> H(+) + melatonin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183072", "l": "EGFR non-clathrin mediated endocytosis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41463", "l": "1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1,2-diacylglycerol + a sphingomyelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936583", "l": "APS is phosphorylated to PAPS (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15019", "l": "an alcohol + phosphate => a phosphate monoester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641134", "l": "SMURF2 binds AXIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202453", "l": "Auto-ubiquitination of TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120086", "l": "(3S)-(+)-asterisca-2(9),6-diene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (3S)-(+)-asterisca-2(9),6-diene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71166", "l": "H(+)(in) + L-alanine(out) + Na(+)(out) <=> H(+)(out) + L-alanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396399", "l": "Fibrillins bind BMPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83677", "l": "C4 deamination of cytidine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29596", "l": "CoA + NADP(+) + sulfoacetaldehyde => H(+) + NADPH + sulfoacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72663", "l": "De novo formation of eIF2:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22265", "l": "3,5,6-trichloropyridin-2-ol + FADH2 + O2 => 3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446077", "l": "BP230 interacts with keretin K5/K14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050481", "l": "mandelate 4-monooxygenase activity", "d": ["Catalysis of the reaction: (S)-mandelate + 5,6,7,8-tetrahydrobiopterin + O2 = (S)-4-hydroxymandelate + 7,8-dihydrobiopterin + H2O. (S)-2-hydroxy-2-phenylacetate is also known as S-mandelate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43660", "l": "ATP + hydrogencarbonate + propanoyl-CoA = ADP + H(+) + methylmalonyl-CoA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047520", "l": "11-cis-retinyl-palmitate hydrolase activity", "d": ["Catalysis of the reaction: 11-cis-retinyl palmitate + H2O = 11-cis-retinol + H+ + palmitate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106435", "l": "carboxylesterase activity", "d": ["Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H(+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110446", "l": "Phospho-Chico: Activated DINR binds p60:Dp110 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210277", "l": "Interaction of PECAM-1 and SHP-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030884", "l": "exogenous lipid antigen binding", "d": ["Binding to an exogenous lipid antigen (examples include microbial lipids and glycolipids)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855047", "l": "Hydrolysis of internal thioester in C4b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53453", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982017", "l": "Active G alpha (q) binds RGS proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69520", "l": "H2O + N-acetyl-D-galactosamino-1,5-lactone = H(+) + N-acetyl-D-galactosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0070735", "l": "protein-glycine ligase activity", "d": ["Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target protein."]}, {"i": "REACT:R-HSA-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134800", "l": "STING dimerization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31799", "l": "4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047704", "l": "bile-salt sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352268", "l": "Cleavage of Satb1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62630", "l": "an alcohol + H2O + NAD(+) => a hydroperoxide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45369", "l": "H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50377", "l": "a ceramide(in) + ATP + H2O => a ceramide(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48705", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => 12S-HpEPE", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29399", "l": "H2O + ITP = diphosphate + H(+) + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928624", "l": "EPHBs bind EFNBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420121", "l": "SFKs phosphorylate PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090415", "l": "7-hydroxymethyl chlorophyll a reductase activity", "d": ["Catalysis of the reaction: 7-hydroxymethyl chlorophyll a + 2 reduced ferredoxin + 2 H+ chlorophyll a + 2 oxidized ferredoxin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51596", "l": "2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] = 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448629", "l": "IL33 binds IL1RL1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48145", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine => ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165028", "l": "Release of the HIV mRNA and Crm1 from Rev in the cytoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50724", "l": "(E)-4-hydroxyphenylacetaldehyde oxime = (Z)-(4-hydroxyphenyl)acetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14314", "l": "2-iodophenol + S-adenosyl-L-methionine => 1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69504", "l": "N-acetyl-D-glucosamine + O2 = H2O2 + N-acetyl-D-glucosamino-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19688", "l": "(E)-feruloyl-CoA + tyramine <=> CoA + H(+) + N-[(E)-feruloyl]tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36659", "l": "carbamoyl phosphate + descarbamoylnovobiocin = novobiocin + phosphate", "d": []}, {"i": "EC:2.1.3.12", "l": "\"decarbamoylnovobiocin carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66534", "l": "diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] => ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985097", "l": "OAS2 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5333051", "l": "RPA1 binds HSF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39376", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA => (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140788", "l": "L-glutamate uniporter activity", "d": ["Catalysis of the active transport of a L-glutamate across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030797", "l": "24-methylenesterol C-methyltransferase activity", "d": ["Catalysis of the reaction: 24-methylidenelophenol + S-adenosyl-L-methionine(1+) = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786155", "l": "POLN binds ICL-DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42465", "l": "biphenyl-2,2',3-triol + O2 => 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11276", "l": "4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O", "d": []}, {"i": "EC:1.10.3.2", "l": "\"laccase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15447", "l": "CO2 + 2 NH4(+) + pyruvate => H(+) + H2O + O-carbamoyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807565", "l": "GNLY is transferred to the phagosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36801", "l": "a ribonucleoside 5'-phosphate + H(+) + phosphate => a ribonucleoside 5'-diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32647", "l": "erythromycin C + S-adenosyl-L-methionine = erythromycin A + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.294", "l": "\"chlorophyll(ide) b reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.8", "l": "\"flavin-containing monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432148", "l": "Fgr may phosphorylate p38 MAPK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33814", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine <=> 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0008875", "l": "gluconate dehydrogenase activity", "d": ["Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009072", "l": "STAT3 phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035401", "l": "histone H3Y41 kinase activity", "d": ["Catalysis of the reaction: histone H3-tyrosine (position 41) + ATP = histone H3-phosphotyrosine (position 41) + ADP. This reaction is the addition of a phosphate group to the tyrosine residue at position 41 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62331", "l": "(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) <=> (+)-malbrancheamide + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27414", "l": "2-oxoglutarate + codeine + O2 => CO2 + formaldehyde + morphine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102370", "l": "lupeol 28-monooxygenase activity", "d": ["Catalysis of the reaction: lupeol + NADPH(4-) + O2 + H+ <=> betulin + NADP(3-) + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55784", "l": "all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate = all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73718", "l": "ATP(in) + dATP(out) <=> ATP(out) + dATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12176", "l": "phenylethanolamine + S-adenosyl-L-methionine = H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928624", "l": "EPHBs bind EFNBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75027", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + 9-hydroxy-octadecanoate = 9-(9Z-hexadecenoyloxy)-octadecanoate + di-(9Z)-hexadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25696", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56363", "l": "13-deoxycarminomycin + H(+) + NADPH + O2 <=> 13-dihydrocarminomycin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27554", "l": "(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate <=> di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52913", "l": "3-dimethylallyl-4-hydroxymandelate + O2 => 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800490", "l": "ATM phosphorylates PIDD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046969", "l": "NAD-dependent histone H3K9 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein."]}, {"i": "REACT:R-HSA-9604829", "l": "SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692867", "l": "HRH3 binds pitosilant (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853429", "l": "PHLDA1 binds AURKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30173", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP] => hexadecanoyl-[ACP] + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14523", "l": "(2E)-geranial + H(+) + NADPH => (2E)-geraniol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018774", "l": "RHOBTB1 binds GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51749", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A => 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62631", "l": "a hydroperoxide + H(+) + NADH <=> an alcohol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030760", "l": "pyridine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.142364941642427", "identifiers": [{"i": "GO:0016782", "l": "transferase activity, transferring sulphur-containing groups", "d": ["Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.8.-.-", "l": "\"Transferring sulfur-containing groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70710", "l": "6-sulfo-beta-D-quinovose <=> 6-sulfo-D-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43806", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18601", "l": "3,4-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO2", "d": []}, {"i": "EC:4.1.1.69", "l": "\"3,4-dihydroxyphthalate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75827", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] = (5S,18)-dihydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52416", "l": "3-dehydro-4-O-phospho-D-erythronate + H(+) = CO2 + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785594", "l": "FANCD2 binds FANCI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102815", "l": "caffeoyl-CoA:delphinidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside betaine + caffeoyl-CoA <=> delphinidin 3-O-glucosyl-5-O-caffeoylglucoside + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848873", "l": "PTK6 phosphorylates ARAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17382", "l": "(9Z,12Z)-octadecadienoate => (9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24863", "l": "H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP => pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033893", "l": "ribonuclease IV activity", "d": ["Catalysis of the endonucleolytic cleavage of poly(A) to fragments terminated by 3'-hydroxy and 5'-phosphate groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20916", "l": "L-cysteine + sulfite = hydrogen sulfide + L-cysteate", "d": []}, {"i": "EC:4.4.1.10", "l": "\"cysteine lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102036", "l": "methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity", "d": ["Catalysis of the reaction: a tetrahydrofolate + a [methyl-Co(III) corrinoid Fe-S protein] <=> an N5-methyl-tetrahydrofolate + a [Co(I) corrinoid Fe-S protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246509", "l": "botC:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72975", "l": "2 ATP + 2 indole-3-pyruvate = 2 AMP + didemethylasterriquinone D + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450325", "l": "c-FOS activation by phospho ERK1/2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050168", "l": "pentanamidase activity", "d": ["Catalysis of the reaction: H2O + pentanamide = NH4 + valerate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799431", "l": "TP53 binds HIPK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197645", "l": "SCARF1 (SREC-I) binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45534", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine => H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43602", "l": "3R-hydroxyeicosanoyl-[ACP] + NADP(+) => 3-oxoeicosanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66934", "l": "avenanthramide A + CoA => (E)-4-coumaroyl-CoA + 5-hydroxyanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72805", "l": "L-arginine(in) + N(omega)-methyl-L-arginine(out) => L-arginine(out) + N(omega)-methyl-L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507875", "l": "Aquaporins passively transport urea into cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917693", "l": "ESCRT Disassembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66050", "l": "(2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate => 2-oxobutanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67492", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679045", "l": "C-ter TLR9 dimer binds HCQ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40582", "l": "1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0004758", "l": "serine C-palmitoyltransferase activity", "d": ["Catalysis of the reaction: L-serine + H+ + palmitoyl-CoA = 3-dehydrosphinganine + CO2 + CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016656", "l": "monodehydroascorbate reductase (NADH) activity", "d": ["Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937369", "l": "ATAD2 binds ESR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50323", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16685", "l": "di-trans,poly-cis-dolichol + hexadecanoyl-CoA = a dolichyl hexadecanoate + CoA", "d": []}, {"i": "EC:2.3.1.123", "l": "\"dolichol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373724", "l": "Nephrin binds NCK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050106", "l": "monomethyl-sulfatase activity", "d": ["Catalysis of the reaction: H2O + monomethyl sulfate = H+ + methanol + sulfate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043905", "l": "L-seryl-tRNA(Thr) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Ser-tRNA(Thr)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196773", "l": "COASY phosphorylates DP-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008096", "l": "juvenile hormone epoxide hydrolase activity", "d": ["Catalysis of the hydrolysis of the epoxide in a juvenile hormone to the corresponding diol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72775", "l": "7-carboxymellein + ATP + L-phenylalanine = ADP + H(+) + ochratoxin B + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696997", "l": "USP24 deubiquitinates DDB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56190", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5631885", "l": "PRDX1 overoxidizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64455", "l": "L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193700", "l": "p75NTR ICD signals to NF-kB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58910", "l": "C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+) => 7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68180", "l": "a short-chain fatty acyl-CoA + H2O = a short-chain fatty acid + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.18", "l": "\"ADP-dependent short-chain-acyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019982", "l": "interleukin-7 binding", "d": ["Binding to interleukin-7."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21764", "l": "heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.18", "l": "\"heme oxygenase (biliverdin-producing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53796", "l": "deoxycholoyl-CoA + ursodeoxycholate = deoxycholate + ursodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183072", "l": "EGFR non-clathrin mediated endocytosis (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13163", "l": "(2S)-2-amino-3-oxobutanoate + H(+) + NADH => L-threonine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30666", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole <=> hapalindole H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18174", "l": "(R)-octopamine => (4-hydroxyphenyl)acetaldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41369", "l": "1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.181", "l": "\"hydroxyanthraquinone glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009282", "l": "CDK1 phosphorylates RUNX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672951", "l": "Inactive RAFs bind YWHAB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164834", "l": "Enzyme-bound ATP is released (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26296", "l": "(1'S,5'S)-averufin + NADPH + O2 <=> 1'-hydroxyversicolorone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15811", "l": "(R)-linalool + diphosphate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30994", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55074", "l": "CO2 + propanal => 2-oxobutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13427", "l": "a pyrimidine nucleobase + D-ribose 5-phosphate => a pyrimidine ribonucleoside 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16215", "l": "3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP => 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9754130", "l": "CDK4 inhibitors bind CDK4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31173", "l": "(2E)-tetradecenoyl-CoA + H2O => (3S)-hydroxytetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944263", "l": "Association of procollagen type II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74715", "l": "Autophosphorylation of insulin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603087", "l": "Defective MAT1A does not transfer Ado from ATP to L-Met (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36333", "l": "diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate => ATP + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35116", "l": "4-coumaroyl-CoA + H(+) + malonyl-CoA => (4-coumaroyl)acetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33205", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50138", "l": "(9Z)-octadecenoate + ethanol + H(+) => ethyl (9Z)-octadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912790", "l": "CBL binds CRK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12887", "l": "GDP + H(+) + O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp) => GDP-alpha-D-mannose + queuosine(34) in tRNA(Asp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23205", "l": "chlorogenate + D-glucarate => 2-O-caffeoylglucarate + L-quinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21912", "l": "CoA + H(+) + O2 + pyruvate = acetyl-CoA + CO2 + H2O2", "d": []}, {"i": "EC:1.2.3.6", "l": "\"pyruvate oxidase (CoA-acetylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31765", "l": "4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid => a 2-oxocarboxylate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71636", "l": "phosphate(in) + 2 thiosulfate(out) => phosphate(out) + 2 thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68170", "l": "2 H(+) + H2O + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase] => N-(8'-oxogeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19551", "l": "H(+) + 2 orsellinate => H2O + o-orsellinate depside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62588", "l": "2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) = 4-hydroxybenzyl alcohol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33109", "l": "diphosphate + gamma-muurolene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15041", "l": "bis-D-fructose 2',1:2,1'-dianhydride + H2O = inulobiose", "d": []}, {"i": "EC:4.2.1.179", "l": "\"difructose-anhydride-I synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42724", "l": "guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.167", "l": "\"27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26479", "l": "1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) => a 2-demethylmenaquinol + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29735", "l": "butane-1-sulfonate + FMNH2 + O2 = butanal + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10468", "l": "D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O", "d": []}, {"i": "EC:4.1.2.9", "l": "\"phosphoketolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19527", "l": "(1S,8aR)-delta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37175", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806629", "l": "Formation of tonofilament bundles (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389026", "l": "Galanin receptors can bind galanin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30045", "l": "iminosuccinate + succinate => fumarate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63758", "l": "flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP => flavokermesate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13327", "l": "3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate => H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70311", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24251", "l": "glyoxylate + L-alanine <=> glycine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051267", "l": "CP2 mannose-ethanolamine phosphotransferase activity", "d": ["Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427570", "l": "Group 3 - Selective Cl- transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25778", "l": "scyllo-inosine => scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70963", "l": "D-phenylalanine + H2O + O2 = 3-phenylpyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47099", "l": "(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate <=> (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675656", "l": "EDA:EDAR binds EDARADD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052893", "l": "N1-acetylspermine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity", "d": ["Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9639567", "l": "NPAS4 gene transcription is repressed by KCNIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40678", "l": "L-threonine <=> 2-aminobut-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637794", "l": "EGFRvIII does not bind CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803255", "l": "HCOOH translocated from mitochondrial matrix to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75985", "l": "(indol-3-yl)acetate(in) + a dicarboxylate(out) => (indol-3-yl)acetate(out) + a dicarboxylate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61284", "l": "H2O + L-cystine + O2 = (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804266", "l": "CHEK2 phosphorylates TTC5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61448", "l": "H(+) + NADPH + O2 + tigecycline = 11a-hydroxytigecycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51067", "l": "3'-phosphoadenylyl sulfate + lithocholate <=> adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63826", "l": "aspulvinone E + H2O => 2 3-(4-hydroxyphenyl)pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0017002", "l": "activin receptor activity", "d": ["Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40930", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66017", "l": "bromide + H2O2 => H2O + hypobromite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68175", "l": "2-oxoglutarate + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + O2 <=> CO2 + H2O + isodomoate A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14388", "l": "a dolichyl diphosphate + H2O <=> a dolichyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62118", "l": "NH4(+) + oxaloacetate => H2O + iminosuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44585", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54909", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH => (4E)-hexenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73879", "l": "histamine(out) = histamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607023", "l": "factor IXa associates with cell membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30484", "l": "N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71740", "l": "2-oxoadipate(in) + 2-oxoglutarate(out) => 2-oxoadipate(out) + 2-oxoglutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45536", "l": "H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21508", "l": "all-trans-retinyl hexadecanoate + H2O = H(+) + hexadecanoate + retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358460", "l": "HPE SHH variants don't undergo autoproteolytic cleavage (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39539", "l": "(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH = (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12744", "l": "ADP + H(+) + H2O <=> IDP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047539", "l": "2-deoxyglucosidase activity", "d": ["Catalysis of the reaction: H2O + a 2-deoxy-alpha-D-glucoside = 2-deoxy-D-glucose + an alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196753", "l": "2xPPCS ligates PPanK with Cys (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607737", "l": "BCL10 oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160935", "l": "SMURF1 ubiquitinates RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32796", "l": "ATP + H2O + L-cysteine(out) => ADP + H(+) + L-cysteine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20492", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) <=> 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204779", "l": "Interaction of Tie2 with Ang1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32087", "l": "[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate = [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate", "d": []}, {"i": "EC:2.5.1.98", "l": "\"Rhizobium leguminosarum exopolysaccharide glucosyl ketal-pyruvate-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66515", "l": "1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73157", "l": "adenosine 3',5'-bisphosphate(in) + FMN(out) => adenosine 3',5'-bisphosphate(out) + FMN(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45100", "l": "6-demethylmitomycin B + S-adenosyl-L-methionine = mitomycin B + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39907", "l": "2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose = dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate", "d": []}, {"i": "EC:2.6.1.106", "l": "\"dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61094", "l": "acetate + L-citrulline => H2O + N(2)-acetyl-L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49160", "l": "1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52381", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40521", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299318", "l": "Activation of TASK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668831", "l": "CST complex formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004057", "l": "arginyl-tRNA--protein transferase activity", "d": ["Catalysis of the reaction: an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H+ + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48954", "l": "14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH => 14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034012", "l": "FAD-AMP lyase (cyclizing) activity", "d": ["Catalysis of the reaction: FAD = AMP + riboflavin cyclic-4',5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848873", "l": "PTK6 phosphorylates ARAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602383", "l": "Defective MyD88 does not oligomerize within the activated TLR2/4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46471", "l": "an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O <=> ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419255", "l": "5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60067", "l": "a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 <=> a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051537", "l": "2 iron, 2 sulfur cluster binding", "d": ["Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875816", "l": "STAT3 binds activated MET receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952996", "l": "E2F7 forms homodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30555", "l": "GTP + L-glutamate + oxidized coenzyme F420-0 = GDP + H(+) + oxidized coenzyme F420-1 + phosphate", "d": []}, {"i": "EC:6.3.2.31", "l": "\"coenzyme F420-0:L-glutamate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71273", "l": "H(+)(out) + thiamine(in) => H(+)(in) + thiamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46529", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29559", "l": "H2O + UDP-alpha-D-glucuronate = 1-phospho-alpha-D-glucuronate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18214", "l": "alpha-D-glucose 1-phosphate + CTP + H(+) => CDP-D-glucose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210289", "l": "Recruitment of SYK to p-DAP12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071857", "l": "beta-endorphin receptor binding", "d": ["Binding to a beta-endorphin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046316", "l": "gluconokinase activity", "d": ["Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797766", "l": "TP53 binds the BIRC5 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47120", "l": "docosanoate + glycine = H2O + N-docosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32072", "l": "geranylgeranyl diphosphate => (13E)-labda-7,13-dien-15-yl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21677", "l": "2 dimethylallyl diphosphate => (R)-lavandulyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213201", "l": "Formation of collagen fibres (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15762", "l": "L-homoserine + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71442", "l": "L-dopa(out) + L-phenylalanine(in) <=> L-dopa(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35931", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose = 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17774", "l": "ATP + L-cysteine + tRNA(Cys) => AMP + diphosphate + L-cysteinyl-tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607023", "l": "factor IXa associates with cell membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416358", "l": "G alpha (q) inhibits PI3K alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9007539", "l": "CHEK1 phosphorylates E2F6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73959", "l": "2-methoxy-4-vinylphenol + H(+) + NADH = 4-ethyl-2-methoxyphenol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160935", "l": "SMURF1 ubiquitinates RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950183", "l": "IL12B binds IL23A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018754", "l": "GDIs bind RHOH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694520", "l": "nsp16 binds VHL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768937", "l": "NPAS4 gene transcription is stimulated by NPAS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76037", "l": "2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + protopine => (S)-cis-N-methylstylopine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875558", "l": "RAPGEF1 binds CRK,CRKL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0016502", "l": "nucleotide receptor activity", "d": ["Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0036458", "l": "hepatocyte growth factor binding", "d": ["Binding to a hepatocyte growth factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21640", "l": "NADP(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH", "d": []}, {"i": "EC:1.3.1.13", "l": "\"prephenate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166041", "l": "Transfer of LPS onto TLR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15661", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside = an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA", "d": []}, {"i": "EC:2.3.1.153", "l": "\"anthocyanin 5-(6'''-hydroxycinnamoyltransferase)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45090", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.169", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106378", "l": "2-hydroxy-dATP hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30144", "l": "H2O + octanoyl-CoA => CoA + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43203", "l": "cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23285", "l": "isopentenyl diphosphate => dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18374", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015517", "l": "galactose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + H+(out) = galactose(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071535", "l": "RING-like zinc finger domain binding", "d": ["Binding to a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.54", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390930", "l": "5-HT2 receptor can bind serotonin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62597", "l": "(S)-8-oxocitronellyl enol + NAD(+) => (6E)-8-oxogeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29204", "l": "dimethyl sulfoxide + menaquinol-8 => dimethyl sulfide + H2O + menaquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38928", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27451", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate => a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418553", "l": "cAMP degradation by Phosphodiesterases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18019", "l": "CO2 + indole-3-acetaldehyde => H(+) + indole-3-pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17426", "l": "CoA + NADP(+) + pyruvate => acetyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140485", "l": "5-aminolevulinic acid transmembrane transporter activity", "d": ["Enables the transfer of 5-aminolevulinic acid from one side of a membrane to the other."]}, {"i": "RHEA:64816", "l": "5-aminolevulinate(in) = 5-aminolevulinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21707", "l": "H2O + L-tyrosine <=> NH4(+) + phenol + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59625", "l": "H2O + N(2)-(4-aminobutanoyl)-L-ornithine => 4-aminobutanoate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165195", "l": "GTP loading by Rheb (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419841", "l": "Light stimulates opsin receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51865", "l": "(2E)-geranyl diphosphate + esculetin => 8-geranylesculetin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45717", "l": "H2O + N,N,N-trimethylglycyl-CoA => CoA + glycine betaine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694727", "l": "Endocytosis of protein 3a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25191", "l": "chloride + glycolate + H(+) => chloroacetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64722", "l": "H(+)(in) + pyruvate(in) => H(+)(out) + pyruvate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3785768", "l": "MRN complex binds DNA double strand breaks (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25519", "l": "an acyl-CoA + tropine <=> CoA + H(+) + O-acyltropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390909", "l": "HRH2 binds hist (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805740", "l": "SETD8 methylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18686", "l": "H(+) + NADPH + O2 + pentachlorophenol => 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28049", "l": "phosphate + propanoyl-CoA <=> CoA + propanoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58938", "l": "all-trans-lycopaoctaene + 2 diphosphate + NAD(+) => 2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15641", "l": "H(+) + oxaloacetate = CO2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213244", "l": "Loading of antigenic peptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483219", "l": "PC is exchanged with PI by PITPNB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72935", "l": "(S)-lactate(out) + 2 Na(+)(out) = (S)-lactate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034930", "l": "1-hydroxypyrene sulfotransferase activity", "d": ["Catalysis of the reaction: 1-hydroxypyrene + XSO3- = 1-pyrenylsulfate + HX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868783", "l": "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676595", "l": "TRAFs bind RANK:RANKL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65364", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O = a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730842", "l": "PI3K associates with phosphorylated GAB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0140658", "l": "ATP-dependent chromatin remodeler activity", "d": ["An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783880", "l": "PIPOX oxidises PPCA to P6C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67071", "l": "AH2 + chermesin D methyl ester <=> A + asnovolin J", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983147", "l": "Release of E3 from polyubiquitinated substrate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58646", "l": "(9Z,12Z,15Z)-octadecatrienamide + glyoxylate => N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035755", "l": "cardiolipin hydrolase activity", "d": ["Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol), releasing phosphatidic acid (PA)."]}, {"i": "REACT:R-HSA-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373074", "l": "Receptor CCR9  binds CCL25 ligand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68988", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445079", "l": "Phosphorylation of L1 by ERK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49377", "l": "12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-171106", "l": "LDLR:LDL complex => LDLR + LDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15650", "l": "carbamate + 2 H(+) => CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53052", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate = 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83650", "l": "FasL:Fas binds FADD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67875", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose <=> 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217150", "l": "Monoubiquitination of FancD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15182", "l": "an acyl-CoA(out) + ATP + H2O => ADP + an acyl-CoA(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507873", "l": "Aquaporins passively transport urea out of cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381091", "l": "IRE1 dimer autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52329", "l": "L-arginine + O2 + reduced [flavodoxin] => H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57894", "l": "a quinol + 4 H(+)(out) + NADP(+) => a quinone + 5 H(+)(in) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "47.173250339744364", "identifiers": [{"i": "GO:0022836", "l": "gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578712", "l": "Importin-8 binds AGO2:miRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624624", "l": "FBXO32 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669158", "l": "NF2 binds PAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371582", "l": "HSBP1 binds HSF1 trimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14020", "l": "ATP + beta-nicotinamide D-riboside <=> ADP + beta-nicotinamide D-ribonucleotide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59989", "l": "cyclohexane-1-carbonyl-CoA + NADP(+) => cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35265", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38117", "l": "1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50965", "l": "cytidine(8) in tRNA + H(+) + H2O => NH4(+) + uridine(8) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60759", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone <=> cinerin I + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046558", "l": "arabinan endo-1,5-alpha-L-arabinosidase activity", "d": ["Catalysis of the endohydrolysis of (1->5)-alpha-arabinofuranosidic linkages in (1->5) arabinans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29514", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-valencene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30799", "l": "(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67633", "l": "a plastoquinone + 6 H(+)(in) + 2 reduced [2Fe-2S]-[ferredoxin] => a plastoquinol + 4 H(+)(out) + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34861", "l": "3-oxocyclopentanecarboxylate + NH4(+) => 3-oxocyclopentanecarbonitrile + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16224", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858252", "l": "HDLBP binds HDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20776", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose = myo-inositol + stachyose", "d": []}, {"i": "EC:2.4.1.67", "l": "\"galactinol--raffinose galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69052", "l": "H(+) + N(omega)-methyl-L-arginine + 2 NADH + 3 O2 = 3 H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+)", "d": []}, {"i": "EC:1.14.13.250", "l": "\"nitrosourea synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57231", "l": "GDP + glyoxal <=> N(2)-(1-hydroxy-2-oxoethyl)-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36943", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29394", "l": "GTP + H2O <=> diphosphate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18307", "l": "CoA + N-acetyl-4-O-acetylneuraminate => acetyl-CoA + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69846", "l": "a 5,6-dihydrouridine in RNA + NAD(+) <=> a uridine in RNA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210944", "l": "Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0072518", "l": "Rho-dependent protein serine/threonine kinase activity", "d": ["Rho GTPase-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22617", "l": "2 H(+) + O2 + 2 sulochrin => 2 (2R)-bisdechlorogeodin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106372", "l": "primary fluorescent dioxobilin-type chlorophyll catabolite methylesterase activity", "d": ["Catalysis of the reaction: H2O + primary fluorescent dioxobilin-type chlorophyll catabolite = H+ + methanol + O13(4)-desmethyl pFCC."]}, {"i": "RHEA:67176", "l": "H2O + primary fluorescent dioxobilin-type chlorophyll catabolite = H(+) + methanol + O13(4)-desmethyl pFDCC", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37742", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13560", "l": "ATP + gamma-L-glutamyl-L-cysteine + glycine <=> ADP + glutathione + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13757", "l": "(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose = (Z)-desulfoglucotropeolin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947531", "l": "Molybdenum ion transfer onto molybdopterin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004853", "l": "uroporphyrinogen decarboxylase activity", "d": ["Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.225", "l": "\"tRNA:m(4)X modification enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046810", "l": "host cell extracellular matrix binding", "d": ["Binding to the extracellular matrix of a host cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30739", "l": "1D-myo-inositol 3-phosphate + H2O = myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33422", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA <=> [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66936", "l": "(E)-caffeoyl-CoA + 5-hydroxyanthranilate = avenanthramide C + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209960", "l": "Diiodinated tyrosine can be deiodinated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141310", "l": "FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62678", "l": "6-thio-IMP + 7,8-dihydrofolate + H2O => 10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3204311", "l": "AOX1 oxidises PXL to PDXate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64933", "l": "dGTP + 2 H2O => dGMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55434", "l": "carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195275", "l": "Phosphorylation of APC component of the destruction complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857686", "l": "FITM1, FITM2 bind TAGs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59511", "l": "fumarate + L-cysteinyl-[protein] <=> S-(2-succinyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56818", "l": "a pyrimidine nucleobase + D-ribose => a pyrimidine ribonucleoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186819", "l": "SH2 domain of Src binds to the active receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46506", "l": "AMP + dodecanoyl-[ACP] + H(+) => dodecanoyl-AMP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35687", "l": "NADP(+) + tetradecasphinganine = 3-oxotetradecasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109700", "l": "AKT2 binds PIP3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047825", "l": "D-lactate-2-sulfatase activity", "d": ["Catalysis of the reaction: (R)-2-O-sulfolactate + H2O = (R)-lactate + H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913374", "l": "Phosphorylated SHC1 recruits SHIP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033887", "l": "chondro-4-sulfatase activity", "d": ["Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2529020", "l": "CK2 phosphorylates condensin I subunits (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.307", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39837", "l": "1-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114254", "l": "CYCS binds to APAF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990465", "l": "aldehyde oxygenase (deformylating) activity", "d": ["Catalysis of the reaction a long-chain aldehyde + O2 + 2 NADPH = an alkane + formate + H2O + 2 NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56927", "l": "ATP + L-threonyl-[Goodpasture antigen-binding protein] <=> ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-419166", "l": "GEFs activate RhoA,B,C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050595", "l": "7-deoxyloganin 7-hydroxylase activity", "d": ["Catalysis of the reaction: 7-deoxyloganin + O2 + reduced [NADPH-hemoprotein reductase] = H+ + H2O + loganin + oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050649", "l": "testosterone 6-beta-hydroxylase activity", "d": ["Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180634", "l": "Association of APOBEC3G with single-stranded region of forming HIV-1 minus strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102918", "l": "(R)-reticuline 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: (R)-reticulinium(1+) + S-adenosyl-L-methionine <=> (R)-laudanine(1+) + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051996", "l": "squalene synthase activity", "d": ["Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38297", "l": "2-oxoglutarate + AH2 => (R)-2-hydroxyglutarate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24563", "l": "acetyl-CoA + L-serine <=> CoA + O-acetyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706328", "l": "Active FLT3 binds to SOCS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754830", "l": "TLR8 dimer binds SARS-CoV-2 GU-rich ssRNA  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730872", "l": "Activation of Calcineurin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23653", "l": "N-terminal L-glutaminyl-[peptide] => N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825615", "l": "Expression of RIPPLY2 in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018754", "l": "GDIs bind RHOH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30676", "l": "tetrahymanol => H2O + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627056", "l": "Procaspase 9 forms dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69634", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18253", "l": "(S)-malate + NADP(+) = CO2 + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49517", "l": "2-oxoglutarate + an N(1)-methyladenosine in mRNA + O2 => an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0042324", "l": "orexin receptor binding", "d": ["Binding to an orexin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174224", "l": "Dissociation of Cdc20 from APC/C complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54215", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 <=> 2-(prostaglandin G2)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72672", "l": "The 60S subunit joins the translation initiation complex  (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392748", "l": "L1 binds to AP-2 Clathrin complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54628", "l": "2-oxoglutarate + dodecanoyl-CoA + O2 = 2-hydroxydodecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73940", "l": "desmethyl-dehydrogriseofulvin + S-adenosyl-L-methionine => dehydrogriseofulvin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30692", "l": "H2O2 + methanol => formaldehyde + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174121", "l": "Association of Securin with Cdc20:APC/C complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0005225", "l": "volume-sensitive anion channel activity", "d": ["Enables the transmembrane transfer of a monoatomic anion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell."]}, {"i": "REACT:R-HSA-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10390", "l": "CO2 + GDP + phosphoenolpyruvate => GTP + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20258", "l": "3-methyloxindole + NADP(+) => 3-methyleneoxindole + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50380", "l": "3 H(+) + 3 malonyl-CoA = 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA", "d": []}, {"i": "EC:2.3.1.253", "l": "\"phloroglucinol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912734", "l": "CBL:CRKL binds RAPGEF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13219", "l": "2 H(+) + NADH + succinate => H2O + NAD(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14701", "l": "2 CoA + NAD(+) = CoA-disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909732", "l": "Phosphorylation of STAT2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021050", "l": "HSBP1 oligomer binds ESRs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.199", "l": "\"beta-mannosylphosphodecaprenol--mannooligosaccharide 6-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873794", "l": "PCTP binds PC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56058", "l": "genistein 7-O-beta-D-glucoside + H(+) + UDP => genistein + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24603", "l": "H2O + O2 + sulfite <=> H2O2 + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36559", "l": "A + cis-4-hydroxy-D-proline = 4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73467", "l": "beta-alanyl-dopamine + H2O = beta-alanine + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40219", "l": "H2O + malonyl-CoA = CoA + H(+) + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168896", "l": "Binding of NS1 to PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33297", "l": "(E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67148", "l": "L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2 = 2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58848", "l": "(6E)-8-hydroxygeraniol + NAD(+) = (6E)-8-hydroxygeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33500", "l": "H(+) + prephenate => 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698933", "l": "HCMV B Nucleocapsid Translocation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265973", "l": "Monoubiquitination of FANCI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25139", "l": "(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) = 3-amino-2-oxopropyl phosphate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37115", "l": "sphing-4-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65445", "l": "butanoyl-CoA + hexan-1-ol => CoA + hexyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22068", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636242", "l": "PPE2:KPNA1:KPNB1 dissociates, releasing PPE2 into the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-481009", "l": "Exocytosis of platelet dense granule content (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24170", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59582", "l": "CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester => hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65911", "l": "3-hydroxy-L-kynurenine + pyruvate <=> H2O + L-alanine + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23460", "l": "benzyl cetraxate + H2O = benzyl alcohol + cetraxate + H(+)", "d": []}, {"i": "EC:3.1.1.70", "l": "\"cetraxate benzylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804383", "l": "PRMT5 methylates TP53 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16197", "l": "(3S)-3-hydroxybutanoyl-CoA + NADP(+) = acetoacetyl-CoA + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.157", "l": "\"3-hydroxybutyryl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473594", "l": "Collagen type II degradation by MMP15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64967", "l": "dUTP + 2 H2O <=> dUMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39148", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707505", "l": "Hemes bind to CLEC1B dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34693", "l": "acryloyl-CoA + H2O => (R)-lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5681980", "l": "ATG12 binds ATG7 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211247", "l": "Cleavage of DNA by DFF40 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874079", "l": "PTK2 binds activated MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855203", "l": "5-PP-IP5 transports from the nucleus to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17842", "l": "trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507871", "l": "Aquaporins passively transport glycerol out of cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156678", "l": "Activation of Cdc25C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421836", "l": "trans-Golgi Network Derived Vesicle Uncoating (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69515", "l": "H2O + N-acetyl-D-galactosamine + O2 <=> H(+) + H2O2 + N-acetyl-D-galactosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40658", "l": "(R)-malate + succinyl-CoA <=> (R)-malyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55774", "l": "a jasmonyl-L-amino acid + AMP + diphosphate + H(+) => a jasmonate + an L-alpha-amino acid + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66830", "l": "2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate => 2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30854", "l": "beta-D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.44", "l": "\"cinnamoyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090486", "l": "small RNA 2'-O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a nucleoside residue in a small RNA molecule. Reaction: S-adenosyl-L-methionine + small RNA = S-adenosyl-L-homocysteine + small RNA containing a 3'-terminal 2'-O-methylnucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74707", "l": "fumagillol + NADP(+) = 5-dehydrofumagillol + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.437", "l": "\"5-dehydrofumagillol 5-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40933", "l": "(3S)-3-hydroxy-L-ornithine + CO2 + succinate => 2-oxoglutarate + L-ornithine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114683", "l": "Phosphorylation of Platelet Sec-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382054", "l": "PDGF binds to extracellular matrix proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177934", "l": "EGFR autophosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44673", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O => a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012542", "l": "IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73327", "l": "(2R,3S)-piscidate + (E)-sinapoyl-CoA = cimicifugate J + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16392", "l": "4-hydroxybenzoate + 2 H(+) + NADH + O2 <=> CO2 + H2O + hydroquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534378", "l": "Hv1 Mediated H+ Permeability (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033935", "l": "oligoxyloglucan beta-glycosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic links in oligoxyloglucans so as to remove successive isoprimeverose (i.e. alpha-xylo-1,6-beta-D-glucosyl-) residues from the non-reducing chain ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651992", "l": "PCNA-containing replication complex binds damaged dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247837", "l": "WNT ligands traffic to the Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53803", "l": "lithocholoyl-CoA + ursodeoxycholate <=> lithocholate + ursodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66644", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + trichobrasilenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68286", "l": "CoA + O-hexanoyl-L-seryl-[protein] => hexanoyl-CoA + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49493", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate => 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1006143", "l": "CD46 binds C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008481", "l": "sphinganine kinase activity", "d": ["Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0008800", "l": "beta-lactamase activity", "d": ["Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75172", "l": "Formation of RAD50:MRE11 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23523", "l": "acetyl-CoA + propanoate <=> acetate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30830", "l": "UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose <=> UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52291", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29728", "l": "ethane-1-sulfonate + FMNH2 + O2 => acetaldehyde + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062070", "l": "SAGA complex binding", "d": ["Binding to a SAGA complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25793", "l": "ATP + Cu(+)(in) + H2O => ADP + Cu(+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31430", "l": "(2E,6E)-farnesyl diphosphate <=> (1S,5S,6R)-alpha-bergamotene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9704297", "l": "CHRM2 binds CHRM2 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48684", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine", "d": []}, {"i": "EC:3.5.1.130", "l": "\"[amino group carrier protein]-lysine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57196", "l": "H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] = glycolate + H(+) + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21093", "l": "12-hydroxydihydrochelirubine + S-adenosyl-L-methionine => dihydromacarpine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57037", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose => (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl](n) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983421", "l": "Journey of cargo through Golgi complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0018031", "l": "peptidyl-lysine N6-palmitoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43790", "l": "ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate => acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37623", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873918", "l": "Transphosphorylation of JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34609", "l": "a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13731", "l": "AMP + H(+) + riboflavin cyclic-4',5'-phosphate => FAD", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36637", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine => 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450348", "l": "Activated human JNKs migrate to nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36274", "l": "caffeine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29581", "l": "Fe(2+)(out) + H(+)(out) => Fe(2+)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033808", "l": "6'-deoxychalcone synthase activity", "d": ["Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62769", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70701", "l": "H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in) => H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683925", "l": "ULK1 is dephosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39788", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67371", "l": "H2O + N-acetyl-L-glutamine <=> acetate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35180", "l": "6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA => 7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5676229", "l": "WIPIs bind PI3P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12993", "l": "cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.10", "l": "\"cyclohex-1-ene-1-carbonyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174124", "l": "Dephosphorylation of phospho-Cdh1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604722", "l": "Activation of proMMP9 by proteases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607756", "l": "TRAF6 oligomer autoubiquitinates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.2.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602966", "l": "Defective FMO3 does not N-oxidise TMA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40381", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167566", "l": "Nef mediated disruption of CD4:Lck Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65142", "l": "A + berkeleyone A + H2O => AH2 + O2 + protoaustinoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48347", "l": "an N-acyl-sphingoid base + UDP-alpha-D-galactose <=> a D-galactosylceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64824", "l": "1-naphthaleneacetamide + H2O = 1-naphthaleneacetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22800", "l": "cycloeucalenol = obtusifoliol", "d": []}, {"i": "EC:5.5.1.9", "l": "\"cycloeucalenol cycloisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002935", "l": "tRNA (adenine-C2-)-methyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(37) in tRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + C2-methyladenine(37) in a tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24247", "l": "NADP(+) + pseudotropine <=> H(+) + NADPH + tropinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51576", "l": "phloretin + UDP-alpha-D-glucose = H(+) + phlorizin + UDP", "d": []}, {"i": "EC:2.4.1.357", "l": "\"phlorizin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730899", "l": "Oligomerization of BCL10 and MALT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23750", "l": "diphosphate + pppGp(2'-5')A => ATP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193646", "l": "NGF binding to p75NTR inactivates RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.185", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166726", "l": "Activation of MASPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953398", "l": "PIR oxygenates quercetin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008882", "l": "[glutamate-ammonia-ligase] adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047131", "l": "saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity", "d": ["Catalysis of the reaction: L-saccharopine + H2O + NAD+ = L-glutamate + allysine + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.167", "l": "\"baicalin-beta-D-glucuronidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66619", "l": "Mg(2+)(in) + 2 Na(+)(out) <=> Mg(2+)(out) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111237", "l": "Formation of ADAR1 homodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614544", "l": "Sulfite is oxidized to sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52901", "l": "3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide => 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73283", "l": "H(+)(out) + L-isoleucine(in) = H(+)(in) + L-isoleucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24799", "l": "(S)-2-amino-6-oxoheptanedioate => (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172666", "l": "RB1 binds condensin II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58112", "l": "1''-O-acetyl-ADP-alpha-D-ribose + H2O = acetate + ADP-D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56539", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661419", "l": "ALB binds extracellular heme (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57441", "l": "2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] => 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.50", "l": "\"human endogenous retrovirus K endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0098633", "l": "collagen fibril binding", "d": ["Binding to a collagen fibril."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130349", "l": "Generation of CLIP from lip10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62880", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2 = (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.2.2", "l": "\"nebramycin 5' synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58702", "l": "FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal => FADH2-C4alpha-hydroperoxide + NADPH + rifampicin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31942", "l": "2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] <=> DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004827", "l": "proline-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36379", "l": "3-dehydro-4alpha-methylzymosterol + H(+) + NADPH = 4alpha-methylzymosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30180", "l": "oxalate + oxidized 2[4Fe-4S]-[ferredoxin] => 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11150", "l": "4 Fe(3+) + 2 H2O => 4 Fe(2+) + 4 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60605", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40237", "l": "coenzyme M-coenzyme B heterodisulfide + succinate => coenzyme B + coenzyme M + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43639", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0016414", "l": "O-octanoyltransferase activity", "d": ["Catalysis of the transfer of an octanoyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664275", "l": "Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71920", "l": "3 Na(+)(out) + succinate(out) => 3 Na(+)(in) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052872", "l": "tocotrienol omega-hydroxylase activity", "d": ["Catalysis of the reaction: tocotrienol + O2 + NADPH + H+ = 13'-hydroxy-tocotrienol + NADP+ + H2O ."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43996", "l": "2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2 = a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60638", "l": "choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate => N-(dodecanoyl)-sphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354087", "l": "Recruitment of GRB2 to p-PTK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23959", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74130", "l": "peonidin + UDP-alpha-D-galactose <=> peonidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420117", "l": "VEGFR2 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51377", "l": "dopamine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoyl-dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9658253", "l": "RAS:GTP binds PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60052", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 = a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69976", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] => (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15817", "l": "H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55646", "l": "ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate => ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654545", "l": "Ligand-independent phosphorylation of overexpressed FGFR1c (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944225", "l": "Association of procollagen type XVII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64630", "l": "CoA + octyl acetate => acetyl-CoA + octan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.62", "l": "\"17beta-estradiol 17-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74379", "l": "2 (S)-lactate(in) + prostaglandin H2(out) = 2 (S)-lactate(out) + prostaglandin H2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17967", "l": "(8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O => (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43430", "l": "1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-didecanoyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15424", "l": "a long-chain fatty acid + ATP + CoA <=> a long-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49281", "l": "FADH2 + O2 + phenol => catechol + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44024", "l": "(3R)-3-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46188", "l": "an aliphatic nitrile + 2 H2O = a carboxylate + NH4(+)", "d": []}, {"i": "EC:3.5.5.7", "l": "\"aliphatic nitrilase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16025", "l": "an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA = an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}, {"i": "EC:2.3.1.171", "l": "\"anthocyanin 6''-O-malonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52173", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24485", "l": "NAD(+) + sulcatol => H(+) + NADH + sulcatone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21302", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate => H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75554", "l": "2 a (3R)-3-isocyanyl-fatty acyl-[ACP] + ATP + L-lysine + 2 NADPH <=> AMP + an isonitrile lipopeptide + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32753", "l": "choline(in) => choline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382061", "l": "Extracellular processing of novel PDGFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067667", "l": "IL6 binds IL6R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102905", "l": "valencene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> (+)-valencene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31225", "l": "beta-D-glucose + cis-2-coumarate => cis-beta-D-glucosyl-2-hydroxycinnamate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68625", "l": "phycoerythrobilin-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71436", "l": "an aromatic L-alpha-amino acid(in) + L-thyroxine(out) => an aromatic L-alpha-amino acid(out) + L-thyroxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39480", "l": "(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38958", "l": "an N-acylsphing-4-enine 1-phosphate(in) <=> an N-acylsphing-4-enine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015221", "l": "lipopolysaccharide transmembrane transporter activity", "d": ["Enables the transfer of lipopolysaccharides from one side of a membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53284", "l": "NAD(+) + scyllo-inosose = 3-dehydro-scyllo-inosose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909718", "l": "Formation of p-STAT1 homodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37275", "l": "H2O + L-alanyl-L-glutamine = L-alanine + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64146", "l": "(9Z)-octadecenoate + L-methionine => H2O + N-(9Z-octadecenoyl)-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25708", "l": "(E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-dihomomethionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73988", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + discoidol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672174", "l": "Ligand-independent dimerization of PDGFRA extracellular domain mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18080", "l": "L-arginyl-[dinitrogen reductase] + NAD(+) <=> H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25175", "l": "L-citrulline + methylamine => H2O + N(omega)-methyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27566", "l": "(2E)-geranyl diphosphate + 7 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 7 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5220959", "l": "TDG excises 5-formylcytosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016618", "l": "hydroxypyruvate reductase activity", "d": ["Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578965", "l": "TNRC6A binds AGO2:miRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43699", "l": "H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate <=> diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46936", "l": "(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = ATP + H(+) + L-2-aminoadipate + NADPH", "d": []}, {"i": "EC:1.2.1.95", "l": "\"L-2-aminoadipate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51255", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374663", "l": "DCC interaction with Ezrin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52755", "l": "H2O + isomaltose <=> beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48307", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73932", "l": "chloride + FADH2 + griseophenone C + O2 => FAD + griseophenone B + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50028", "l": "H2O + tetradecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5333051", "l": "RPA1 binds HSF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22248", "l": "7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) = 7,8-dihydroxykynurenate + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.18", "l": "\"kynurenate-7,8-dihydrodiol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36408", "l": "ATP + hydrogencarbonate + L-threonine => diphosphate + H2O + L-threonylcarbamoyladenylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088439", "l": "FOXM1 binds CENPF promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64045", "l": "(13Z)-docosenoyl-CoA + sphing-4-enine => CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57033", "l": "(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O => CO2 + formate + methylamine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40451", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47193", "l": "coenzyme M + methyl-Co(III)-[methylated-thiol-specific corrinoid protein] => Co(I)-[methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390930", "l": "5-HT2 receptor can bind serotonin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35036", "l": "4-aminobutanoate(in) => 4-aminobutanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41205", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33794", "l": "H2O + sucrose 6(F)-phosphate <=> beta-D-fructose + beta-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48150", "l": "ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate => ganglioside GT1b (d18:1(4E)/18:0) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390598", "l": "Myosin Binds ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37848", "l": "13-dihydrodaunorubicin + H(+) + NADPH + O2 => daunorubicin + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73473", "l": "D-ornithine(out) + L-ornithine(in) => D-ornithine(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33648", "l": "(9Z)-hexadecenoate + ATP + CoA => (9Z)-hexadecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004900", "l": "erythropoietin receptor activity", "d": ["Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28629", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone => O2 + reduced [NADPH--hemoprotein reductase] + solavetivol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53383", "l": "5,6-dihydrouridine(16) in tRNA + NAD(+) <=> H(+) + NADH + uridine(16) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209566", "l": "TRAF6 is auto-ubiquitinated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849857", "l": "KLK5 cleaves and activates CELA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050546", "l": "4-hydroxyphenylpyruvate decarboxylase activity", "d": ["Catalysis of the reaction: (4-hydroxyphenyl)pyruvate + H+ = (4-hydroxyphenyl)acetaldehyde + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018594", "l": "MECP2 binds LBR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63542", "l": "L-leucine + neurotensin-(1-12) => H2O + neurotensin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981931", "l": "RAC1 and CDC42 activate PAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47274", "l": "bisanhydrobacterioruberin + H2O => monoanhydrobacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63527", "l": "2-propylphenol + H(+) + NADH + O2 <=> 3-propylcatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031432", "l": "titin binding", "d": ["Binding to titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59930", "l": "D-erythrose + H(+) + NADPH => erythritol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73723", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate = (2R,3S,11S)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67730", "l": "diphosphate + DNA(n)-Z => DNA(n) + dZTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64500", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine = 3-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26454", "l": "NADP(+) + propanoyl-CoA = acryloyl-CoA + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.84", "l": "\"acrylyl-CoA reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40550", "l": "10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21203", "l": "2-oxoglutarate + L-lysine <=> (S)-2-amino-6-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69625", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193981", "l": "CYP21A2 oxidises 17HPROG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69293", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate => goitrin + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3903017", "l": "SUMOylation of PPARGC1A with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685606", "l": "CLEC2D binds KLRB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41799", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38620", "l": "nicotinate beta-D-ribonucleotide + phenol => H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51287", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate <=> (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3785684", "l": "Fibronectin degradation by CTSG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209973", "l": "Tyrosine is diiodinated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25582", "l": "beta-L-fucose => alpha-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44615", "l": "3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66782", "l": "N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate => 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46454", "l": "cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu) => 2 L-leucyl-tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57576", "l": "7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54749", "l": "ATP + CoA + firefly L-luciferin => AMP + diphosphate + L-firefly luciferyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848250", "l": "ACBD6 binds LCFA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37801", "l": "2 H2O + 2 NAD(+) => 2 H(+) + 2 NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033776", "l": "phenylacetone monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + phenylacetone = benzyl acetate + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730835", "l": "Autophosphorylation of PKC-theta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70046", "l": "6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676268", "l": "Formation of the MLL4 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614271", "l": "Autocleavage of ADGRG6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66116", "l": "2-oxobutanoate + L-glutamine = (2S)-2-aminobutanoate + 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68355", "l": "pppA(2'-5')pG <=> 3',2'-cGAMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36245", "l": "(E)-coumaryl acetate + NADPH => (E)-anol + acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855077", "l": "Ficolin-3 binds to molecular patterns on the target cell surface  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58379", "l": "decan-1-ol + NADP(+) <=> decanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64810", "l": "CoA + H(+) + O-(2-acetamidoethyl)-L-serine => acetyl-CoA + O-(2-aminoethyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29965", "l": "H(+)(out) + inosine(out) => H(+)(in) + inosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698026", "l": "FLT3 ITD- and STAT5-dependent BCL2L1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21852", "l": "(R)-10-hydroxyoctadecanoate = (9Z)-octadecenoate + H2O", "d": []}, {"i": "EC:4.2.1.53", "l": "\"oleate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051993", "l": "abscisic acid glucose ester beta-glucosidase activity", "d": ["Catalysis of the reaction: abscisic acid glucose ester + H2O = abscisic acid + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71473", "l": "L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6) => H2O + substance P", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75911", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine = a fatty acid + H(+) + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983150", "l": "Proteasomal cleavage of substrate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16257", "l": "alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate", "d": []}, {"i": "EC:2.4.1.231", "l": "\"alpha,alpha-trehalose phosphorylase (configuration-retaining)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67174", "l": "formate + 2 H(+) + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite => O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12553", "l": "(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA => (E)-pinosylvin + 4 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015228", "l": "coenzyme A transmembrane transporter activity", "d": ["Enables the transfer of coenzyme A from one side of a membrane to the other. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0120014", "l": "phospholipid transfer activity", "d": ["Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61227", "l": "H2O + L-asparagine + O2 <=> 2-oxosuccinamate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10591", "l": "4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH <=> 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13034", "l": "aldehydo-D-galactose 6-phosphate => keto-D-tagatose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019140", "l": "inositol 3-kinase activity", "d": ["Catalysis of the reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46021", "l": "[pyruvate, water dikinase] + ADP => [pyruvate, water dikinase]-phosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24506", "l": "4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61416", "l": "(S)-8-oxocitronellyl enol = cis-trans-nepetalactol", "d": []}, {"i": "EC:5.5.1.34", "l": "\"(+)-cis,trans-nepetalactol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62655", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA <=> 6 CO2 + 7 CoA + H2O + naphtopyrone YWA1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202222", "l": "Phosphorylation of PKC theta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72773", "l": "7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56916", "l": "3beta-hydroxy-5alpha-androstan-17-one + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008120", "l": "ceramide glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56568", "l": "globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine = globoside IV3GalNAc-Gb4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70153", "l": "6alpha-hydroxy-28-norcastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41315", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211219", "l": "Translocation of caspase-3 to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937369", "l": "ATAD2 binds ESR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018480", "l": "5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002145", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity", "d": ["Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12688", "l": "2 mycothiol + NADP(+) <=> H(+) + mycothione + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062148", "l": "L-gamma-glutamyl-L-propargylglycine hydroxylase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 = CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate."]}, {"i": "RHEA:59900", "l": "2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 = CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55712", "l": "(S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O = (9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75773", "l": "(10S)-hydroxy-(12Z,15Z)-octadecadienoate => (9Z,12Z,15Z)-octadecatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45194", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36061", "l": "AH2 + urocanate => A + dihydrourocanate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034888", "l": "endosulfan monooxygenase I activity", "d": ["Catalysis of the reaction: endosulfan + O2 + 2 H+ + 2 e- = endosulfan sulfate + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0071667", "l": "DNA/RNA hybrid binding", "d": ["Binding to a RNA/DNA hybrid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14724", "l": "UDP-alpha-D-xylose + zeatin <=> H(+) + O-beta-D-xylosylzeatin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67057", "l": "chermesin D + S-adenosyl-L-methionine => chermesin D methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38457", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57663", "l": "(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13153", "l": "(R)-glycerate + CO2 + NAD(+) = 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37537", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213244", "l": "Loading of antigenic peptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65495", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41392", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205286", "l": "GRB2:SOS interacts with p-KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68151", "l": "2-octanone + H(+) + NADPH <=> (2R)-octan-2-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47117", "l": "eicosanoate + glycine => H2O + N-eicosanoylglycinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2106615", "l": "Removal of siRNA passenger strand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046848", "l": "hydroxyapatite binding", "d": ["Binding to hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66671", "l": "5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875443", "l": "USP8 deubiquitinates LRIG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351948", "l": "Mitochondrial recruitment of Drp1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9661432", "l": "BIL binds ALB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48239", "l": "2 2-acetylphloroglucinol <=> 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67525", "l": "4,8-dimethylnonanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32178", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose <=> alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18763", "l": "a fatty acid + a monoacylglycerol + H(+) => a 1,2-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668545", "l": "NIK autophosphorylates on T559 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51719", "l": "ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046980", "l": "tapasin binding", "d": ["Binding to tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55265", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine => di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14027", "l": "NH4(+) + xanthopterin-B2 => H(+) + H2O + sepiapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51600", "l": "2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22845", "l": "(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134954", "l": "DHX9 binds DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42666", "l": "H(+) + L-arabinono-1,4-lactone + NADPH => alpha-L-arabinopyanose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018717", "l": "9-phenanthrol glycosyltransferase activity", "d": ["Catalysis of the reaction: 9-phenanthrol + glucose = 9-phenanthryl-beta-D-glucopyranoside + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14797", "l": "2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42008", "l": "5alpha-pregnan-20beta-ol-3-one + NAD(+) = 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39205", "l": "NADP(+) + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9660192", "l": "VDR agonists bind VDR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981713", "l": "C4b binds to cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140111", "l": "[choline trimethylamine-lyase]-activating enzyme activity", "d": ["Catalyzes the activation of choline trimethylamine-lyase by generation of an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36982", "l": "(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72180", "l": "Cleavage of mRNA at the 3'-end (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41843", "l": "3-oxooctanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyoctanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38165", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12311", "l": "(S)-2-amino-6-oxohexanoate + H2O + NAD(+) <=> 2 H(+) + L-2-aminoadipate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2562564", "l": "Caspase-8 processing within TLR4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59236", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + isoelisabethatriene", "d": []}, {"i": "EC:4.2.3.203", "l": "\"isoelisabethatriene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75833", "l": "5-oxo-18-hydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => 5-oxo-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19806", "l": "a purine D-ribonucleoside + phosphate => a purine nucleobase + alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0005504", "l": "fatty acid binding", "d": ["Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25956", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3-dehydroquinate + H(+) + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.24", "l": "\"3-dehydroquinate synthase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60920", "l": "2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2 = a cytidine in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72347", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + veratrole = 3-methoxyphenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71913", "l": "cholate(in) + 2 Na(+)(in) => cholate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52760", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O = (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14945", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.46", "l": "\"monogalactosyldiacylglycerol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35289", "l": "ADP + chloramphenicol(out) + H(+) + phosphate => ATP + chloramphenicol(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674140", "l": "PAQR3 binds inactive RAFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004924", "l": "oncostatin-M receptor activity", "d": ["Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060961", "l": "phospholipase D inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of phospholipase D."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696547", "l": "STAMBPL1 is a deubiquitinase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42058", "l": "13-cis-retinal + H(+) + NADH => 13-cis-retinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75832", "l": "5-oxo-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] => 5-oxo-18-hydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15705", "l": "2 a ubiquinone + H2O + phenylacetyl-CoA = 2 a ubiquinol + phenylglyoxylyl-CoA", "d": []}, {"i": "EC:1.17.5.1", "l": "\"phenylacetyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033515", "l": "TYSND1 cleaves ACOX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951499", "l": "Loading of antigenic peptides on to class I MHC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47340", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47520", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isolithocholate + NADP(+)", "d": []}, {"i": "EC:1.1.1.393", "l": "\"3beta-hydroxycholanate 3-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68027", "l": "H2O + presqualene monophosphate <=> phosphate + presqualene alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010190", "l": "ROBO3 binds NELL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863472", "l": "DAB2 binds LRP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.33", "l": "\"pikromycin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65348", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA = 3-oxochol-4,6-dien-24-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54936", "l": "(2E)-decenoyl-[ACP] + H(+) + NADH = decanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17878", "l": "a catechol + S-adenosyl-L-methionine => a guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71237", "l": "[3Fe-4S](0)-[protein] + Fe(3+)-[Dph3] => [3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69292", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate = goitrin + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55591", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35240", "l": "tetracycline(in) => tetracycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27386", "l": "H2O + maleamate => maleate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37102", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O <=> a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25318", "l": "2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate <=> L-2-acetamido-6-oxoheptanedioate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863471", "l": "LDLR is bound by DAB2 and ARH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033963", "l": "cholesterol-5,6-oxide hydrolase activity", "d": ["Catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol, and 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1370500", "l": "PRLR binds SCF beta-TrCP complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12648", "l": "CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462014", "l": "Alpha-defensins form biologically active dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40356", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43901", "l": "dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O => beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75217", "l": "H(+) + L-fucono-1,5-lactone + NADPH => beta-L-fucose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12316", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}, {"i": "EC:3.1.3.64", "l": "\"phosphatidylinositol-3-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28139", "l": "H2O + streptothricin F => streptothricin F acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.78", "l": "\"mannan endo-1,4-beta-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41498", "l": "1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626817", "l": "PKC phosphorylates NCF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372542", "l": "Loading of dopamine into synaptic veiscles (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-179421", "l": "Degradation of multiubiquitinated Nek2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609274", "l": "Active FLT3 binds HCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0099107", "l": "ion channel regulator activity involved in G protein-coupled receptor signaling pathway", "d": ["Modulation of the activity of an ion channel via direct interaction with it as part of G protein-coupled receptor signaling."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53764", "l": "allocholate + lithocholoyl-CoA = allocholoyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20246", "l": "ATP + streptomycin => 3''-O-adenylylstreptomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.47", "l": "\"[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17239", "l": "diphosphate + FAD => ATP + FMN + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088299", "l": "FOXM1 stimulates CCNB2 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47457", "l": "(3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+) => 3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.102", "l": "\"DNA primase AEP\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050223", "l": "protocatechuate decarboxylase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxybenzoate + H+ = catechol + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944232", "l": "Association of procollagen type XII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64799", "l": "H2O + L-lysine + NADP(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69703", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphingosine + H2O = beta-D-galactose + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74160", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61660", "l": "(2E)-geraniol + ATP = (2E)-geranyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64680", "l": "benzoyl-CoA + ethanol = CoA + ethyl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59036", "l": "4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24003", "l": "a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] <=> a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44462", "l": "a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046789", "l": "host cell surface receptor binding", "d": ["Binding to a receptor on the host cell surface."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73880", "l": "histamine(out) => histamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909552", "l": "Phosphorylation of STAT1 at Ser727 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052764", "l": "exo-oligoalginate lyase activity", "d": ["Catalysis of the cleavage of glycosidic bonds through a beta-elimination reaction on alginate, a linear polysaccharide consisting of guluronate (G) and mannuronate (M) as the monomer constituents. An oligoalginate is a linear polymer of two, three or four units of (1->4)-alpha-L-guluronic acid and beta-D-mannuronic acid, releasing monosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends."]}, {"i": "EC:4.2.2.26", "l": "\"oligo-alginate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103097", "l": "CYP79F1 trihomomethionine monooxygenase activity", "d": ["Catalysis of the reaction: trihomomethionine + 2 O2 + 2 NADPH + 2 H+ <=> 3 H2O + carbon dioxide + 2 NADP + 6-methylthiohexanaldoxime."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24413", "l": "4-(hydroxymethyl)benzenesulfonate + NAD(+) => 4-formylbenzenesulfonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76103", "l": "(11R)-carlactonoate + S-adenosyl-L-methionine = (11R)-methyl carlactonoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42263", "l": "H(+) + heptanoyl-CoA + malonyl-[ACP] <=> 3-oxononanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672175", "l": "Autophosphorylation of PDGFR mutant dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41183", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66314", "l": "a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+) => an alpha-mannosylinositol-1-phosphoceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71988", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + fusoxypene C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13746", "l": "ascopyrone M => microthecin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28999", "l": "H(+)(out) + homoserine lactone(in) = H(+)(in) + homoserine lactone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202717", "l": "Heterodimerization of CEACAMs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72793", "l": "bilirubin-glucuronoside(in) => bilirubin-glucuronoside(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70919", "l": "chloride(out) + dopamine(out) + Na(+)(out) = chloride(in) + dopamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9639286", "l": "RRAGC,D exchanges GTP for GDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5336443", "l": "LIN7, CASK and APBA1 bind (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44660", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69790", "l": "(2-aminophenyl)succinate + succinyl-CoA <=> 3-(2-aminophenyl)succinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56949", "l": "pyruvate + UTP => H(+) + phosphoenolpyruvate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033939", "l": "xylan alpha-1,2-glucuronosidase activity", "d": ["Catalysis of the hydrolysis of alpha-D-(1->2)-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0048030", "l": "disaccharide binding", "d": ["Binding to a disaccharide. Disaccharides are sugars composed of two monosaccharide units."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624033", "l": "Initiation of HCMV DNA Replication (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15277", "l": "acetyl-CoA + L-lysyl-[alpha-tubulin] = CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]", "d": []}, {"i": "EC:2.3.1.108", "l": "\"alpha-tubulin N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73472", "l": "D-ornithine(in) + L-ornithine(out) => D-ornithine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34550", "l": "ATP + cob(II)yrinate + H2O + L-glutamine <=> ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610726", "l": "The IFT-A complex recruits TULP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44002", "l": "2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69074", "l": "Formation of Processive Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37522", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33851", "l": "GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) = GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047758", "l": "ATP:2-methylpropanoate phosphotransferase activity", "d": ["Catalysis of the reaction: 2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13509", "l": "H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}, {"i": "EC:2.7.7.23", "l": "\"UDP-N-acetylglucosamine diphosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74236", "l": "H2O + L-threonyl-tRNA(Ser) => L-threonine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13234", "l": "guanosine + phosphate => alpha-D-ribose 1-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805981", "l": "HMGB1 release from cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42730", "l": "2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2791) in 21S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18220", "l": "2-oxoglutarate + an alkane-alpha,omega-diamine <=> an omega-aminoaldehyde + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2317314", "l": "AKT binds PDPK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684071", "l": "RNF4 ubiquitinates MDC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2534096", "l": "METAP1/2 demethylates GNAT1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299297", "l": "Activation of THIK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57919", "l": "ATP + L-aspartyl-tRNA(Asn) <=> 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985201", "l": "ABCE1 binds RNASEL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60367", "l": "H(+)(out) + myo-inositol(out) <=> H(+)(in) + myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71321", "l": "chloride(in) + L-cysteine(in) + 2 Na(+)(in) => chloride(out) + L-cysteine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69893", "l": "Na(+)(in) + thymidine(in) => Na(+)(out) + thymidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30730", "l": "dATP + pyruvate <=> dADP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635667", "l": "esxG:esxH binds HGS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450723", "l": "RAC1:GTP and MSN activate HEP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417898", "l": "P2Y4 receptor can bind to UTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-532549", "l": "MPI isomerises Fru6P to Man6P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55967", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.264511229695032", "identifiers": [{"i": "GO:0016833", "l": "oxo-acid-lyase activity", "d": ["Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878054", "l": "HIPK2 phosphorylates RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16323", "l": "H(+) + indan-1-one + NADPH => (S)-indan-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14171", "l": "ADP + glutaryl-CoA + phosphate => ATP + CoA + glutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38625", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52890", "l": "H(+) + NADPH + nitrosobenzene => N-phenylhydroxylamine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190829", "l": "Lysosomal degradation of gap junction plaques (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54493", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine => 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668904", "l": "Formation of the CTF18 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140561", "l": "EGF-domain serine glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + [protein with EGF-like domain]-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944247", "l": "Association of procollagen type VI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64441", "l": "glycylglycyl-L-proline(out) + H(+)(out) => glycylglycyl-L-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22571", "l": "ascopyrone M <=> ascopyrone P", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58740", "l": "H2O + psi-UTP = diphosphate + H(+) + psi-UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33750", "l": "a 1-acyl-sn-glycerol + ATP <=> a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31107", "l": "3-phenylpyruvate + O2 = (2-hydroxyphenyl)acetate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36817", "l": "dTDP-alpha-D-fucofuranose => dTDP-alpha-D-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40754", "l": "(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22833", "l": "H2O + N-formimidoyl-L-glutamate => N-formyl-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005133", "l": "type II interferon receptor binding", "d": ["Binding to a type II interferon receptor. Type II interferon is also known as interferon-gamma."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928646", "l": "EPHAs bind EFNAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65394", "l": "(8aS)-octahydroindolizin-1-one + CO2 + CoA + 2 H2O + 2 NADP(+) => 4 H(+) + L-pipecolate + malonyl-CoA + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-398185", "l": "LARG binds plexin B1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37731", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69160", "l": "agmatine + H2O + O2 = H2O2 + N-amidino-(2R)-hydroxypyrrolidine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062193", "l": "D-ribose pyranase activity", "d": ["Catalysis of the reaction: beta-D-ribopyranose = beta-D-ribofuranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73897", "l": "ADP + gamma-L-glutamylspermine + H(+) + phosphate => ATP + L-glutamate + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983688", "l": "OAS1 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19458", "l": "2-nitrophenol + 2 H(+) + 2 NADPH + O2 => catechol + H2O + 2 NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15936", "l": "(S)-propane-1,2-diol + NAD(+) <=> (S)-lactaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047854", "l": "diguanidinobutanase activity", "d": ["Catalysis of the reaction: 1,4-diguanidinobutane + H2O = agmatine + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55038", "l": "an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N,N-dimethylornithine lipid + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1370505", "l": "PRLR is phosphorylated at Ser-349 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004368", "l": "glycerol-3-phosphate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-377640", "l": "Autophosphorylation of SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28927", "l": "3,4,5-trihydroxybenzoate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)", "d": []}, {"i": "EC:1.13.11.57", "l": "\"gallate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71645", "l": "H(+) + N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide => guanosine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018562", "l": "3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxyfluorene + O2 = 2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55254", "l": "2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28601", "l": "H2O + N-acetyl-L-lysine <=> acetate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.-", "l": "\"Serine-type carboxypeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139899", "l": "Sequestration of BAD protein by 14-3-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51290", "l": "(13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54296", "l": "GTP + L-tyrosyl-[protein] = diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein]", "d": []}, {"i": "EC:2.7.7.n6", "l": "\"guanine phosphate-protein transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13031", "l": "H(+) + H2O2 + N-acetyl-D-glucosaminate => H2O + N-acetyl-D-glucosamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59381", "l": "4-amino-4-deoxyprephenate + NAD(+) => 3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57770", "l": "3-methylcatechol + NAD(+) + nitrite => 2-nitrotoluene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69012", "l": "5beta-dihydrotestosterone + H(+) + NADPH = 5beta-androstane-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10940", "l": "(2E)-geranyl diphosphate = (4R)-limonene + diphosphate", "d": []}, {"i": "EC:4.2.3.20", "l": "\"(R)-limonene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35729", "l": "1-dodecanoyl-sn-glycerol 3-phosphate + CoA => dodecanoyl-CoA + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977371", "l": "Factor I inactivates Factor H-boundC3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69435", "l": "3 [thioredoxin]-dithiol + arsenic triglutathione + 3 S-adenosyl-L-methionine <=> 3 [thioredoxin]-disulfide + 3 glutathione + 3 H(+) + 3 S-adenosyl-L-homocysteine + trimethylarsine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59132", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP = AMP + diphosphate + H(+) + staphyloferrin B", "d": []}, {"i": "EC:6.3.2.56", "l": "\"staphyloferrin B synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11587", "l": "L-ornithine <=> D-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033829", "l": "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416562", "l": "p190RhoGAP binds Plexin-B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51699", "l": "desmethylxanthohumol + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + xanthohumol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66013", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen] => [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48825", "l": "GDP-beta-L-fucose + Lc4Cer => a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63221", "l": "7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine => 5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19961", "l": "a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate = a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside", "d": []}, {"i": "EC:2.7.1.77", "l": "\"nucleoside phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627107", "l": "XIAP binds CASP7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35251", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(in) + ATP + H2O = ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26559", "l": "(3S)-3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.53", "l": "\"Mn(2+)-dependent ADP-ribose/CDP-alcohol diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74475", "l": "(Z)-4'-methoxydehydrocyclopeptine + 2-oxoglutarate + O2 = (-)-4'-methoxycyclopenine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050090", "l": "mannuronate reductase activity", "d": ["Catalysis of the reaction: D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19663", "l": "beta-D-fructose 6-phosphate + H(+) + NADH => D-mannitol 1-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47717", "l": "4-pregnen-20,21-diol-3-one + NAD(+) => 21-hydroxyprogesterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3321805", "l": "NSL acetylates histone H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605717", "l": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168136", "l": "Activated JNKs phosphorylate c-JUN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17977", "l": "a long-chain primary fatty alcohol + H2O + 2 NAD(+) = a long-chain fatty acid + 3 H(+) + 2 NADH", "d": []}, {"i": "EC:1.1.1.192", "l": "\"long-chain-alcohol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428515", "l": "Recruitment of SOS to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68580", "l": "ATP + H2O + L-kynurenine(out) = ADP + H(+) + L-kynurenine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4411383", "l": "NLK phosphorylates TCF/LEF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299359", "l": "Activation of TALK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60615", "l": "1-octanoyl-sn-glycero-3-phosphocholine <=> 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69500", "l": "L-arginyl-[protein] + NAD(+) = ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69405", "l": "uracil(in) => uracil(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050436", "l": "microfibril binding", "d": ["Binding to a microfibril, any small fibril occurring in biological material."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68675", "l": "16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 16alpha,17beta-estriol 16-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31913", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate => beta-D-fructose 1,6-bisphosphate + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9736953", "l": "FURIN translocates to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253319", "l": "ERBB4s80:TAB2:NCOR1 complex translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39991", "l": "(4R)-hydroxyeicosasphinganine + a fatty acyl-CoA = CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5225649", "l": "RBBP7 binds histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296462", "l": "Defective CUBN does not transport GIF:Cbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66224", "l": "asc-C9-CoA + O2 = asc-DeltaC9-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42182", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33350", "l": "2-iminoacetate + H2O <=> glyoxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56833", "l": "2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) => 2,3,6-trichlorohydroquinone + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38516", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68960", "l": "DNA polymerase epsilon binds at the origin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73986", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-beta-barbatene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669870", "l": "Regorafenib-resistant KIT mutants do not bind regorafenib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195733", "l": "M2 protein synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67238", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + CoA => mycophenolyl-CoA + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71057", "l": "L-cysteine(in) + L-methionine(out) => L-cysteine(out) + L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70886", "l": "H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out) <=> H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42721", "l": "S-adenosyl-L-methionine + uridine(2552) in 23S rRNA => 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.74", "l": "\"chalcone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53826", "l": "7-oxotaurolithocholate + H(+) + NADH => NAD(+) + taurochenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450063", "l": "Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46337", "l": "3-oxochola-4,17-dien-22-oyl-CoA + H2O => 17-hydroxy-3-oxochol-4-en-22-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047430", "l": "oligosaccharide-diphosphodolichol diphosphatase activity", "d": ["Catalysis of the reaction: H2O + oligosaccharide-diphosphodolichol = dolichol-phosphate + oligosaccharide phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30229", "l": "dimethyl sulfoxide + 2 Fe(II)-[cytochrome c2] + 2 H(+) => dimethyl sulfide + 2 Fe(III)-[cytochrome c2] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021068", "l": "PalmS-ESRs bind CAVs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63025", "l": "(13Z)-docosenamide + H2O => (13Z)-docosenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15084", "l": "acetate + ATP + CoA <=> acetyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0030882", "l": "lipid antigen binding", "d": ["Binding to a lipid antigen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26504", "l": "2 H(+) + ternatin C5 + UDP => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51407", "l": "H2O + L-arginine + O2 <=> 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60913", "l": "cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74618", "l": "UDP-alpha-D-galactose(in) + UDP-alpha-D-glucose(out) <=> UDP-alpha-D-galactose(out) + UDP-alpha-D-glucose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53233", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44191", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633441", "l": "TP53 stimulates transcription of TNFRSF10A, TNFRSF10B,TNFRSF10C and TNFRSF10D genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63583", "l": "20-hydroxyecdysone 22-phosphate + H2O <=> 20-hydroxyecdysone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68006", "l": "A + chloride + ethene + H(+) => AH2 + chloroethene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429036", "l": "SLC2A9 transports Fru, Glc, urate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44938", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate => (9Z,12Z,15Z)-octadecatrienoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381217", "l": "IRE1:BiP dissociates in response to unfolded protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685605", "l": "SLAMF7 binds SLAMF7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2467775", "l": "Autocleavage of ESPL1 (Separase) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55006", "l": "3-isopropenyl-6-oxoheptanoate + H2O + NADP(+) => 1-hydroxylimonen-2-one + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664867", "l": "NBR1 binds MAP1LC3B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008613", "l": "diuretic hormone activity", "d": ["The action characteristic of a diuretic hormone, a peptide hormone that, upon receptor binding, regulates water balance and fluid secretion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.124", "l": "\"3-deoxy-2-octulosonidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72671", "l": "eIF5B:GTP is hydrolyzed and released (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66129", "l": "2-oxobutanoate + L-phenylalanine => (2S)-2-aminobutanoate + 3-phenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950778", "l": "p-Y693-STAT4 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177942", "l": "EGFR binds EGF ligand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032041", "l": "NAD-dependent histone H3K14 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000120", "l": "CBLIF binds RCbl (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010283", "l": "pinoresinol reductase activity", "d": ["Catalysis of the reaction: pinoresinol + NADPH + H+ = lariciresinol + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381668", "l": "cAMP activates EPAC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17440", "l": "2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate <=> (2E,4E)-2,4-dichloromuconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047055", "l": "salutaridine synthase activity", "d": ["Catalysis of the reaction: (R)-reticuline + [reduced NADPH--hemoprotein reductase] + O2 -> salutaridine + [oxidized NADPH--hemoprotein reductase] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868236", "l": "BAR domain proteins recruit dynamin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47796", "l": "an aralkylamine + H2O + 2 oxidized [azurin] = an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": []}, {"i": "EC:1.4.9.2", "l": "\"aralkylamine dehydrogenase (azurin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805811", "l": "Release of SEPT4 from mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849102", "l": "SRMS phosphorylates PTK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68923", "l": "ATP + H(+) + NADPH + pentanoate <=> AMP + diphosphate + NADP(+) + pentanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.48", "l": "\"low-specificity L-threonine aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036202", "l": "ent-cassa-12,15-diene 11-hydroxylase activity", "d": ["Catalysis of the reaction: ent-cassa-12,15-diene + O2 + NADPH + H+ = ent-11beta-hydroxycassa-12,15-diene + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32141", "l": "AMP + diphosphate + malonyl-CoA => ATP + CoA + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047568", "l": "3-oxo-5-beta-steroid 4-dehydrogenase activity", "d": ["Catalysis of the reaction: a 3-oxo-5-beta-steroid + acceptor = a 3-oxo-D4-steroid + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10953", "l": "(E)-sinapoyl-CoA + hydroxymalonate => (E)-sinapoyltartronate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033509", "l": "USP9X binds Ub:PEX5L (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369052", "l": "ABCAs mediate lipid influx (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73379", "l": "(R)-lipoate(out) + 2 Na(+)(out) = (R)-lipoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.79", "l": "\"3beta,22alpha-dihydroxysteroid 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32210", "l": "(2E,4Z)-2-hydroxyhexa-2,4-dienedioate <=> (3Z)-2-oxohex-3-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707586", "l": "FeHM oxidises LDL,HDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15083", "l": "acetyl-CoA + ADP + phosphate => acetate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49844", "l": "(-)-dehydrodiconiferyl acid + a quinone = (-)-dehydrodiconiferyl acid ketone + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64001", "l": "(4R)-hydroxysphinganine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71150", "l": "3-hydroxyhispidin + O2 <=> 4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11142", "l": "D-mannose 6-phosphate => alpha-D-mannose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451311", "l": "Activation of Ca-permeable Kainate receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0097621", "l": "monoamine oxidase activity", "d": ["Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45329", "l": "7,8-dihydroneopterin => 7,8-dihydromonapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51549", "l": "(R)-tetrahydropapaverine + S-adenosyl-L-methionine => (R)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.29", "l": "\"phycobiliprotein cysteine-84 phycobilin lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446634", "l": "IRAK4 is activated by autophosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73502", "l": "3',4',7-trihydroxyflavone + S-adenosyl-L-methionine <=> 4',7-dihydroxy-3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807496", "l": "POU2F1 (OCT1) or POU2F2 (OCT2), SP1, and ZNF143 (STAF) bind the DSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050490", "l": "1,4-lactonase activity", "d": ["Catalysis of the reaction: H2O + a 1,4-lactone = a 4-hydroxyacid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48900", "l": "chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] = 3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939335", "l": "RNF181 polyubiquinates BCL10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13873", "l": "(+)-copalyl diphosphate = abieta-7,13-diene + diphosphate", "d": []}, {"i": "EC:4.2.3.18", "l": "\"abieta-7,13-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798257", "l": "PTPRS binds NTRK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036105", "l": "peroxisome membrane class-1 targeting sequence binding", "d": ["Binding to a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209330", "l": "Phosphorylated BSK kinase and the AP-1 transcription factor, JRA:KAY, bind to CKA scaffolding protein in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47427", "l": "(2E,9Z)-octadecadienoyl-CoA + H2O <=> (3S)-hydroxy-(9Z-octadecenoyl)-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714483", "l": "RAC2 translocates to the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5631885", "l": "PRDX1 overoxidizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112392", "l": "Resumption of elongation after recovery from pausing (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61273", "l": "H2O + L-2-aminopentanoate + O2 => 2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2090079", "l": "GLB1 hydrolyses linker chain(2) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20406", "l": "H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate => (2S,6S)-2,6-diaminoheptanedioate + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140981", "l": "medium-chain fatty acid omega-hydroxylase activity", "d": ["Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102014", "l": "beta-D-galactose-importing ATPase activity", "d": ["Catalysis of the reaction: ATP(4-) + beta-D-galactoside + H2O <=> ADP(3-) + hydrogenphosphate + beta-D-galactoside + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32301", "l": "2 diphosphate + NAD(+) + squalene => 2 (2E,6E)-farnesyl diphosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17759", "l": "3-(methylsulfanyl)propanamine + CO2 => H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73613", "l": "CTP(in) + dCDP(out) => CTP(out) + dCDP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73744", "l": "2 H(+)(out) + serotonin(in) => 2 H(+)(in) + serotonin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005328", "l": "neurotransmitter:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47937", "l": "4-hydroxybenzaldehyde + H2O + NADP(+) => 4-hydroxybenzoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047426", "l": "ricinine nitrilase activity", "d": ["Catalysis of the reaction: H2O + ricinine = NH3 + 3-carboxy-4-methoxy-N-methyl-2-pyridone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031881", "l": "type 4 somatostatin receptor binding", "d": ["Binding to a type 4 somatostatin receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004654", "l": "polyribonucleotide nucleotidyltransferase activity", "d": ["Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140496", "l": "gamma-tubulin complex binding", "d": ["Binding to a gamma-tubulin complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985594", "l": "MYO9B inactivates RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37584", "l": "D-lysine + H2O + O2 => 6-amino-2-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51325", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => (8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34158", "l": "acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine <=> CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592232", "l": "Expression of TFB1M (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36249", "l": "(E)-anethole + H(+) + S-adenosyl-L-homocysteine => (E)-anol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32403", "l": "(1R,2S,4R)-neodihydrocarveol + NAD(+) = (1R,4R)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110244", "l": "Excision of FapyG by OGG1 glycosylase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983425", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43027", "l": "an S-substituted L-cysteine <=> 2-aminoprop-2-enoate + a thiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44829", "l": "(R)-carnitine + decanoyl-CoA => CoA + O-decanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75136", "l": "NADP(+) + neopine => H(+) + NADPH + neopinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60649", "l": "an N-(acyl)-sphingosylphosphoethanolamine => an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210921", "l": "NEUROG3-dependent synthesis of NKX2-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047178", "l": "glycerophospholipid acyltransferase (CoA-dependent) activity", "d": ["Catalysis of the reaction: 1-radyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-radyl-2-acyl-sn-glycero-3-phosphocholine = 1-radyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acyl-sn-glycero-3-phosphoethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173111", "l": "Disassembly of viral capsid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71470", "l": "H2O + substance P <=> L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35581", "l": "anthocyanin A11 + D-glucose => 1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41196", "l": "1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848316", "l": "IL36 binds IL1RL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44810", "l": "2-demethylmenaquinol-10 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109862", "l": "MAP2K2 phosphorylates MAPK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40603", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687088", "l": "PKA phosphorylates MAPKAPK5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691621", "l": "C5 binds C5 inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22289", "l": "an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O => an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15635", "l": "2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+) => 3,4-dihydroxyphenylacetate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781941", "l": "WNTs are secreted in exosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444572", "l": "Zinc is an agonist of GPR39 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30851", "l": "beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1006169", "l": "Factor H binds host cell surface markers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761452", "l": "CTNNA1 binds to CDH11-bound CTNNB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442938", "l": "activated MAPK3/MAPK6 migrates to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854981", "l": "SHC1 in the RET complex is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2272668", "l": "Interaction of DAP12 and KIR2DS5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199839", "l": "AKT can phosphorylate RSK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27523", "l": "2,5-dihydroxypyridine + O2 => H(+) + N-formylmaleamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66353", "l": "(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+) => (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51747", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A <=> a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73944", "l": "dehydrogriseofulvin + H(+) + NADPH => griseofulvin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981728", "l": "Factor H binds to membrane-associated C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70883", "l": "H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out) = H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432487", "l": "CWO binds to cwo gene and represses transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52421", "l": "O-phospho-L-serine + thiosulfate => phosphate + S-sulfo-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042657", "l": "MHC class II protein binding, via lateral surface", "d": ["Binding to the lateral surface of major histocompatibility complex class II molecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201611", "l": "Caspase-mediated cleavage of Rock-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249378", "l": "STING recruits TBK1 and STAT6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750942", "l": "USP14 deubiquitinates NLRC5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805479", "l": "TP53RK phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-434650", "l": "MATEs mediate extrusion of xenobiotics (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.240751554780076", "identifiers": [{"i": "GO:0015605", "l": "organophosphate ester transmembrane transporter activity", "d": ["Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109813", "l": "GRB2-1 binds SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22260", "l": "H2O + triacetate lactone = H(+) + triacetate", "d": []}, {"i": "EC:3.1.1.38", "l": "\"triacetate-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69430", "l": "arsenic triglutathione + 3 H2O => arsenite + 3 glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675473", "l": "SH2B binds JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626816", "l": "PIN1 binds p-S345-NCF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3857336", "l": "CEBPB homodimerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47271", "l": "bacterioruberin <=> H2O + monoanhydrobacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10938", "l": "6-decylubiquinol + tetrathionate => 6-decylubiquinone + 2 thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47775", "l": "a guanosine in 21S rRNA + S-adenosyl-L-methionine <=> a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54704", "l": "N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68092", "l": "a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA = a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57218", "l": "N(2)-(1-hydroxy-2-oxoethyl)-dGTP => dGTP + glyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694555", "l": "Protein M localizes to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61647", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine <=> 2 Fe(III)-[cytochrome b5] + H2O + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102055", "l": "12-hydroxyjasmonate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + a 12-hydroxyjasmonate <=> adenosine 3',5'-bismonophosphate + a 12-hydroxyjasmonate sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42538", "l": "pseudouridine(65) in tRNA => uridine(65) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63762", "l": "1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863472", "l": "DAB2 binds LRP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58730", "l": "H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine => adenosine in rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165680", "l": "Formation of active mTORC1 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22364", "l": "L-quinate + NAD(+) = 3-dehydroquinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676255", "l": "Formation of the MLL2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69152", "l": "Removal of remaining Flap (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20899", "l": "ATP + hydrogencarbonate + urea <=> ADP + H(+) + phosphate + urea-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52741", "l": "glyphosate + H2O + O2 => aminomethylphosphonate + glyoxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.3", "l": "\"DNA 5'-3' helicase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.1.-", "l": "\"Linked to oxidoreductase reactions\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28099", "l": "ATP + GDP => AMP + guanosine 3',5'-bis(diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65139", "l": "(9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624133", "l": "ARL3:GTP binds the UNC119B complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13360", "l": "3-hydroxypropanoate + NAD(+) <=> 3-oxopropanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430347", "l": "MigFilin associates with Filamin and F-actin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28769", "l": "acetaldehyde + chemical entity + H(+) + nitrite => ethylnitronate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0071714", "l": "icosanoid transmembrane transporter activity", "d": ["Enables the transfer of icosanoids from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850818", "l": "SPINK9 binds KLK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2129357", "l": "Fibrillin C-terminal processing (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48056", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = beta-D-glucosylceramide + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39902", "l": "7-deoxyloganetin + UDP-alpha-D-glucose <=> 7-deoxyloganin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43929", "l": "pregn-5-ene-3,20-dione => progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40165", "l": "(R)-glycerate + 2 H(+) + NADPH => D-glyceraldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71997", "l": "diphosphate + preaspterpenacid acid I => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24355", "l": "ethyl (R)-3-hydroxyhexanoate + NADP(+) <=> ethyl 3-oxohexanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25614", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => terpentedienyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0005310", "l": "dicarboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661625", "l": "FVIII is secreted (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67395", "l": "2-oxo-ATP + H2O <=> 2-oxo-AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13660", "l": "acetyl-[citrate lyase ACP] + H2O <=> acetate + H(+) + holo-[citrate lyase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706336", "l": "Active FLT3 binds to SYK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73734", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate <=> (2S,3R,11S)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015441", "l": "ABC-type beta-glucan transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + beta-glucan(in) = ADP + phosphate + beta-glucan(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58677", "l": "NADPH + O2 + rifamycin SV => H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65966", "l": "ADP + H(+) + phosphate + taurocholate(in) => ATP + H2O + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.461014234140904", "identifiers": [{"i": "GO:0004714", "l": "transmembrane receptor protein tyrosine kinase activity", "d": ["Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31793", "l": "(13S)-edaxadiene + diphosphate => H2O + tuberculosinyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43272", "l": "ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GD2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68603", "l": "ORC5 binds ORC2:ORC3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10200", "l": "butanoate + NAD(+) = (2E)-2-butenoate + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.31", "l": "\"2-enoate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34048", "l": "6'''-deamino-6'''-hydroxyneomycin C + O2 => 6'''-deamino-6'''-oxoneomycin C + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27388", "l": "H2O + maleamate <=> maleate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25479", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-himachalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34167", "l": "2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)", "d": []}, {"i": "EC:3.7.1.19", "l": "\"2,6-dihydroxypseudooxynicotine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23627", "l": "a 5,6-dihydrouridine in tRNA + NADP(+) <=> a uridine in tRNA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58498", "l": "glycolaldehyde + H2O + NAD(+) + trimethylamine => choline + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65066", "l": "diphosphate + pestalodiol => dimethylallyl diphosphate + siccayne", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047601", "l": "acetate kinase (diphosphate) activity", "d": ["Catalysis of the reaction: acetate + diphosphate = acetyl phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39413", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5607721", "l": "Activation of NIK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44471", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3244643", "l": "STING binds cyclic GMP-AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211247", "l": "Cleavage of DNA by DFF40 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682026", "l": "MRN bound to shortened telomeres activates ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9603784", "l": "PEX19:class I PMP binds PEX3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25934", "l": "4-methylquinolin-2(1H)-one + AH2 => 4-methylquinoline + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65400", "l": "butan-1-ol + butanoyl-CoA = butyl butanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30908", "l": "(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) => 2-methylbutanoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785594", "l": "FANCD2 binds FANCI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17997", "l": "Co-precorrin-2 + S-adenosyl-L-methionine = Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.151", "l": "\"cobalt-factor II C(20)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043721", "l": "4-hydroxybutanoyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: 4-hydroxybutanoyl-CoA = vinylacetyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624800", "l": "CDK1 phosphorylates LBR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48496", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose = 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41514", "l": "H2O + N(5)-hydroxy-L-ornithine + NAD(+) => L-ornithine + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73762", "l": "guanosine(2553) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2553) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769394", "l": "AKT phosphorylates CBY1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63528", "l": "[thioredoxin]-dithiol + H2O2 = [thioredoxin]-disulfide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674015", "l": "Olaratumab binds PDGFRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140444", "l": "cytoskeleton-nuclear membrane anchor activity", "d": ["The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71214", "l": "chlorate(out) + 2 Na(+)(out) <=> chlorate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27615", "l": "(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate => di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047699", "l": "beta-diketone hydrolase activity", "d": ["Catalysis of the reaction: H2O + nonane-4,6-dione = butanoate + H+ + pentan-2-one."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9726621", "l": "PGR binds PGR antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51353", "l": "H2O + N-(9Z-octadecenoyl)-L-serine => (9Z)-octadecenoate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112396", "l": "Separation of elongating transcript from template (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32655", "l": "a carboxylate + eugenol + NADP(+) = a coniferyl ester + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53568", "l": "12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41185", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823966", "l": "EOMES, SMAD2,3, MIXL1 bind the GSC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139919", "l": "Translocation of BIM to mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74082", "l": "H(+) + menaquinone-4 + NADH <=> menaquinol-4 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110311", "l": "POLZ extends translesion synthesis (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39430", "l": "(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH <=> (23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692764", "l": "MAPK6 binds CCND3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112266", "l": "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66361", "l": "(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O => (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13081", "l": "biotin amide + H2O = biotin + NH4(+)", "d": []}, {"i": "EC:3.5.1.12", "l": "\"biotinidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72150", "l": "AH2 + S-adenosyl-L-methionine + UTP <=> 3'-deoxy-3',4'-didehydro-UTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36853", "l": "3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA => (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964482", "l": "DREAM complex binds the E2F1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29091", "l": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)", "d": []}, {"i": "EC:7.1.1.2", "l": "\"NADH:ubiquinone reductase (H(+)-translocating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694377", "l": "pp1a cleaves itself (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71020", "l": "L-phenylalanine(out) + L-valine(in) => L-phenylalanine(in) + L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592244", "l": "AMPK phosphorylates PPARGC1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50162", "l": "N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61326", "l": "3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031755", "l": "Edg-2 lysophosphatidic acid receptor binding", "d": ["Binding to an Edg-2 lysophosphatidic acid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63257", "l": "1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32375", "l": "limonene-1,2-diol + NAD(+) = 1-hydroxylimonen-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102705", "l": "serine decarboxylase activity", "d": ["Catalysis of the reaction: H+ + L-serine <=> ethanolaminium(1+) + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353058", "l": "glucose 6-phosphate + H2O => glucose + phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63023", "l": "(9Z,12Z)-octadecadienamide + H2O <=> (9Z,12Z)-octadecadienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74050", "l": "L-alanine(in) + L-valine(out) <=> L-alanine(out) + L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981606", "l": "Myoglobin binds oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71206", "l": "L-homoarginine(in) <=> L-homoarginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16313", "l": "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": []}, {"i": "EC:3.1.1.66", "l": "\"5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58354", "l": "CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43047", "l": "hexadecasphinganine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65072", "l": "(2E,6E)-farnesyl diphosphate = dauca-4,7-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49238", "l": "L-histidyl-[protein] + sucrose 6(G)-phosphate(in) => N(pros)-phospho-L-histidyl-[protein](out) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24710", "l": "2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose = L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose", "d": []}, {"i": "EC:2.6.1.87", "l": "\"UDP-4-amino-4-deoxy-L-arabinose aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53719", "l": "H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP <=> phosphate + UDP-N-acetyl-alpha-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855155", "l": "I(1,3,4,5,6)P5 transports from the ER lumen to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696268", "l": "RND3 binds effectors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12481", "l": "5-aminolevulinate + pyruvate => 4,5-dioxopentanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420688", "l": "GABAB heterodimeric receptor binds GABA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20069", "l": "(Z)-phenylacetaldehyde oxime = H2O + phenylacetonitrile", "d": []}, {"i": "EC:4.8.1.4", "l": "\"phenylacetaldoxime dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047951", "l": "glutathione thiolesterase activity", "d": ["Catalysis of the reaction: S-acylglutathione + H2O = a carboxylate + glutathione + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42509", "l": "6-acetamido-2-oxohexanoate + H2O + NAD(+) => 5-acetamidopentanoate + CO2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873918", "l": "Transphosphorylation of JAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32240", "l": "gamma-carotene => all-trans-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21013", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine => 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55546", "l": "H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => L-lysyl-[citrate synthase] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17737", "l": "NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50532", "l": "acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34782", "l": "a 3alpha-hydroxysteroid + NAD(+) <=> a 3-oxosteroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31622", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694551", "l": "3CLp cleaves nsp6-11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202500", "l": "Activation of IKK complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193656", "l": "p75NTR interacts with RIP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44632", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + O2 = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+)", "d": []}, {"i": "EC:1.13.11.80", "l": "\"(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675790", "l": "MTORC1 dissociates from ULK complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32472", "l": "demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] => (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373745", "l": "SDK1 homophillic interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65148", "l": "phloretin + UDP-alpha-D-glucose = H(+) + trilobatin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21140", "l": "ATP + inosine = ADP + H(+) + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709179", "l": "DPP4 binds DPP4 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76055", "l": "norreticuline + S-adenosyl-L-methionine = H(+) + reticuline + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58643", "l": "a 5'-end (5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine <=> a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62357", "l": "8-oxo-GDP + H2O => 8-oxo-GMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508292", "l": "SYK binds IL2RB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853762", "l": "RET dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877902", "l": "Activated AR binds RUNX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37541", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396399", "l": "Fibrillins bind BMPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426489", "l": "RISC binds inexactly matching target RNAs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60666", "l": "NADH + phosphate => H2O + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16953", "l": "2-oxoglutarate + N(2)-succinyl-L-ornithine = L-glutamate + N-succinyl-L-glutamate 5-semialdehyde", "d": []}, {"i": "EC:2.6.1.81", "l": "\"succinylornithine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112037", "l": "Inactivation of PLC beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65618", "l": "25-hydroxycholest-4-en-3-one + AH2 => A + cholest-4-en-3-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74366", "l": "coproporphyrin III(out) <=> coproporphyrin III(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451377", "l": "Interaction of IQGAP1 with nephrin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22028", "l": "acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate", "d": []}, {"i": "EC:2.3.1.162", "l": "\"taxadien-5alpha-ol O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49837", "l": "(5E)-tetradecenoyl-CoA + (R)-carnitine => (5E)-tetradecenoyl-(R)-carnitine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607746", "l": "PKC-delta is activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12093", "l": "(S)-acetoin => (R)-acetoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26491", "l": "a secondary nitroalkane + H2O + O2 => a ketone + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800298", "l": "HGF dimer binds MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420233", "l": "VIP receptors bind VIP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177920", "l": "Binding of GRB2 to GAB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56311", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23032", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.3.1", "l": "\"phosphoribosylformylglycinamidine cyclo-ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604763", "l": "Autocatalytic activation of MMP7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58466", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP => a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75891", "l": "Abortive Initiation After Second Transition (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43513", "l": "2-(dihydroxymethyl)-5-formylfuran + O2 => 2-carboxy-5-formylfuran + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0005030", "l": "neurotrophin receptor activity", "d": ["Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805740", "l": "SETD8 methylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12963", "l": "acetoacetyl-CoA + butanoate => acetoacetate + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-933533", "l": "Dimerization of p-IRF7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070034", "l": "telomerase RNA binding", "d": ["Binding to the telomerase RNA template."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59839", "l": "H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] <=> 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75721", "l": "4'-phosphopantetheinyl-CoA disulfide + adenosine 3',5'-bisphosphate + 2 H(+) => CoA-disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164515", "l": "Fusogenic activation of gp41 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36887", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530584", "l": "CREM (CREMP) binds to surface-bound C3b or C4b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73599", "l": "CDP(in) + CTP(out) = CDP(out) + CTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202714", "l": "CD58 binds CD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60932", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651828", "l": "PARG dePARylates PARP1,PARP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813740", "l": "GDE1 hydrolyzes GroPIns (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19550", "l": "H2O + o-orsellinate depside => H(+) + 2 orsellinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66801", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005105", "l": "type 1 fibroblast growth factor receptor binding", "d": ["Binding to a type 1 fibroblast growth factor receptor (FGFR1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63964", "l": "sphinga-4E,14Z-dienine-1-phosphate = (2E,12Z)-hexadecadienal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38349", "l": "2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate => (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847880", "l": "CYTH proteins bind ARF1:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57042", "l": "D-apiofuranose => aldehydo-D-apiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14039", "l": "cortisone + H(+) + NADPH => 4,5beta-dihydrocortisone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9656244", "l": "DRD2 binds DA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36456", "l": "ATP + H2O + L-alanylglycine(out) => ADP + H(+) + L-alanylglycine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5688786", "l": "ATXN3 binds RAD23 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50521", "l": "acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57100", "l": "S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thio-D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52355", "l": "(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate <=> (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38414", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694568", "l": "Nucleoprotein translocates to the ERGIC outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688834", "l": "ATXN3 binds VCP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22706", "l": "4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+) => 2 H2O + ricinine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130619", "l": "TGN-lysosomal vesicle coat assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11850", "l": "[thioredoxin]-dithiol + glycine betaine + H(+) + phosphate => [thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008674", "l": "2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity", "d": ["Catalysis of the reaction: 6-phospho-2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800794", "l": "PIDD1 associates with CRADD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15921", "l": "2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol = a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol", "d": []}, {"i": "EC:2.4.1.184", "l": "\"galactolipid galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27961", "l": "cytidine + H2O <=> cytosine + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4411373", "l": "NLK translocates to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061897", "l": "all-trans retinal 3,4-desaturase activity", "d": ["Catalysis of the reaction: all-trans-retinal + 2 H+ + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinal + 2 H2O + 2 oxidized [adrenodoxin]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015462", "l": "ABC-type protein transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139917", "l": "tBID activates BAX protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41073", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178178", "l": "PP1 dephosphorylates TGFBR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380508", "l": "Translocation of NuMA to the centrosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72437", "l": "(E)-caffeoyl-CoA + AMP + H(+) => (E)-caffeoyl-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098620", "l": "seryl-selenocysteinyl-tRNA kinase activity", "d": ["Catalysis of the reaction: Ser-tRNA(Sec) + ATP = Sep-tRNA(Sec) + ADP."]}, {"i": "REACT:R-HSA-2408507", "l": "Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59877", "l": "(indol-3-yl)butanoate + ATP + L-cysteine => (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45192", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75272", "l": "S-adenosyl-L-methionine + serotonin => 5-methoxytryptamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66504", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61797", "l": "holo-[peptidyl-carrier protein] + L-tryptophyl-5'-AMP => AMP + L-tryptophyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161567", "l": "LTB4 is oxidised to 12-oxoLTB4 by PTGR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74217", "l": "L-serine + tRNA(Lys) => H2O + L-seryl-tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23426", "l": "D-glucosamine 6-phosphate => alpha-D-glucosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.112", "l": "\"anthocyanidin reductase [(2S)-flavan-3-ol-forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35848", "l": "ATP + sphing-4-enine => ADP + H(+) + sphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983152", "l": "Transfer of ubiquitin from E1 to E2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30941", "l": "ADP + dITP => ATP + dIDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50901", "l": "10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O => (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47737", "l": "cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112755", "l": "SOCS3 binds IL6ST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797090", "l": "CCNK binds CDK12 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14164", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 <=> 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43727", "l": "(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866321", "l": "VLDL binds APOC1 and APOC4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29018", "l": "phosphate(out) + sn-glycerol 3-phosphate(in) <=> phosphate(in) + sn-glycerol 3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66886", "l": "11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13621", "l": "4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose", "d": []}, {"i": "EC:5.4.99.15", "l": "\"(1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25619", "l": "diphosphate + terpentetriene => terpentedienyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683925", "l": "ULK1 is dephosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374669", "l": "L1 binds NRP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70321", "l": "1D-myo-inositol 3,4-bisphosphate + phosphate => 1D-myo-inositol 1,3,4-trisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31232", "l": "4-acetamidobutanal + H2O + NAD(+) => 4-acetamidobutanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60959", "l": "17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose <=> (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31316", "l": "(2R)-3-phosphoglycerate + GDP-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032142", "l": "single guanine insertion binding", "d": ["Binding to a double-stranded DNA region containing a single guanine insertion or a deletion that results in an unpaired guanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299338", "l": "Activation of TRESK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32681", "l": "(2E)-geraniol + diphosphate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58860", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34495", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48109", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44618", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+) => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198371", "l": "AKT phosphorylates GSK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0035005", "l": "1-phosphatidylinositol-4-phosphate 3-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50819", "l": "androst-4-ene-3,17-dione + H(+) + NADPH <=> 5alpha-androstan-3,17-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730856", "l": "Autophosphorylation of PAK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69959", "l": "6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70724", "l": "sitosterol(out) => sitosterol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050050", "l": "leucine N-acetyltransferase activity", "d": ["Catalysis of the reaction: L-leucine + acetyl-CoA = N-acetyl-L-leucine + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050198", "l": "pinosylvin synthase activity", "d": ["Catalysis of the reaction: trans-cinnamoyl-CoA + 3 H+ + 3 malonyl-CoA = 4 CO2 + 4 CoA + pinosylvin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47459", "l": "(3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+) <=> 3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41922", "l": "(3R)-hydroxyoctadecanoyl-[ACP] + NADP(+) => 3-oxooctadecanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70148", "l": "6-deoxo-28-norcastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 28-norcastasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50367", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019702", "l": "protein arginine N5-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N5-methyl-L-arginine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10616", "l": "(2R,3S)-catechin + H2O + NADP(+) = (2R,3S,4S)-leucocyanidin + H(+) + NADPH", "d": []}, {"i": "EC:1.17.1.3", "l": "\"leucoanthocyanidin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43726", "l": "H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase] => (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168848", "l": "tBID binds to inactive BAK protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006325", "l": "EPO binds EPOR:JAK2:LYN:IRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166542", "l": "beta-NGF dimer binds to TrkA receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0008482", "l": "sulfite oxidase activity", "d": ["Catalysis of the reaction: H2O + O2 + sulfite = H2O2 + H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0010209", "l": "vacuolar sorting signal binding", "d": ["Binding to a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40882", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38157", "l": "(6E,10E)-geranyllinalool + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49408", "l": "[(1->2)-beta-D-mannosyl](n) + phosphate = [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": []}, {"i": "EC:2.4.1.340", "l": "\"1,2-beta-oligomannan phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15914", "l": "ATP + thiamine phosphate => ADP + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.132", "l": "\"chitosanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42718", "l": "(2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate => (2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38333", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol => 1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357828", "l": "RIPK1 is cleaved by CASP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9703895", "l": "CASR binds CASR agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985943", "l": "p-Y701-STAT1 dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462041", "l": "HNP1-4 are released into phagocytic vacuoles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37019", "l": "A + D-serine + H2O = 3-hydroxypyruvate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68349", "l": "ATP + GTP => diphosphate + pppA(2'-5')pG", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47522", "l": "isolithocholate + NADP(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987214", "l": "p-STAT3 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74643", "l": "CMP-N-acetyl-beta-neuraminate(in) + UMP(out) = CMP-N-acetyl-beta-neuraminate(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679029", "l": "C-ter TLR7 dimer binds HCQ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17128", "l": "H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine <=> 2-oxoglutarate + N-(2-aminobutanoyl)glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32399", "l": "(1S,2R,4S)-neodihydrocarveol + NAD(+) = (1S,4S)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5226999", "l": "ADD1:ADD3 binds DMTN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62413", "l": "(E)-feruloyl-CoA + H2O => acetyl-CoA + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49496", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+) = 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682020", "l": "MRN complex binds shortened telomeres (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71268", "l": "chloride(out) + L-pipecolate(out) + 2 Na(+)(out) => chloride(in) + L-pipecolate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626220", "l": "C2CD3 binds the mother centriole (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380574", "l": "Dopamine synaptic vesicle docking and priming (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793988", "l": "LUBAC ubiquitinates CFLAR at K351, K353 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65186", "l": "berkeleyone B + CO2 + H2O + succinate => 2-oxoglutarate + O2 + preaustinoid A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429860", "l": "DCP1-DCP2 complex decaps mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72732", "l": "UDP-alpha-D-glucose(in) + UMP(out) => UDP-alpha-D-glucose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000263", "l": "TCN2:RCbl is degraded to release RCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21609", "l": "isoliquiritigenin + S-adenosyl-L-methionine => 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50817", "l": "androst-4-ene-3,17-dione + H(+) + NADPH => 5alpha-androstan-3,17-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517705", "l": "p-S318,221-HuR binds mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59898", "l": "ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate => ATP + L-glutamate + L-propargylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391913", "l": "FPR2 binds FPR2 ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5432825", "l": "HMGB1 binds TLR4:LY96 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60201", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49307", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16204", "l": "4-amino-4-deoxychorismate <=> 4-aminobenzoate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0050136", "l": "NADH dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32479", "l": "2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH", "d": []}, {"i": "EC:1.21.1.1", "l": "\"iodotyrosine deiodinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010698", "l": "acetyltransferase activator activity", "d": ["Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71594", "l": "2-oxoglutarate(out) + malonate(in) <=> 2-oxoglutarate(in) + malonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450387", "l": "HuR binds the CRM1 nuclear export machinery (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68347", "l": "ATP + GTP <=> 3',2'-cGAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419490", "l": "Binding of ATP to P2X receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21185", "l": "a dolichyl phosphate + GDP-alpha-D-mannose => a dolichyl beta-D-mannosyl phosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73922", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + H(+) <=> H2O + norlichexanthone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61840", "l": "brassicasterol + UDP-alpha-D-glucose = brassicasterol 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375160", "l": "NCAM1 binds to ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75161", "l": "H(+) + NADP(+) + TDP => NAD(+) + TTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57873", "l": "(E)-2,4-dihydroxycinnamoyl-CoA => CoA + umbelliferone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870469", "l": "RGGT geranylgeranylates RAB proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0016632", "l": "oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a cytochrome."]}, {"i": "EC:1.3.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507868", "l": "Aquaporins passively transport water into cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26446", "l": "3-oxopropanoate + CoA + NADP(+) = H(+) + malonyl-CoA + NADPH", "d": []}, {"i": "EC:1.2.1.75", "l": "\"malonyl CoA reductase (malonate semialdehyde-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0008381", "l": "mechanosensitive monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress."]}, {"i": "TCDB:1.A.23.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651789", "l": "LIG1 bound to POLB ligates SSB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0003845", "l": "11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity", "d": ["Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52327", "l": "2 L-arginine + 4 O2 + 3 reduced [flavodoxin] <=> 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0008384", "l": "IkappaB kinase activity", "d": ["Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4837364", "l": "Secretion of SOD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51138", "l": "(10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64827", "l": "1-naphthaleneacetamide + H2O <=> 1-naphthaleneacetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36896", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682388", "l": "Autophagosome maturation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27707", "l": "ATP + D-alanine + D-serine => ADP + D-alanyl-D-serine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18831", "l": "(R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH => 4-phospho-D-erythronate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189439", "l": "ALAD condenses 2 dALAs to form PBG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14971", "l": "(E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trans-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937034", "l": "IRAK1 phosphorylates Pellino (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202291", "l": "Activation of Lck (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50884", "l": "(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z-octadecenoyl)-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20192", "l": "5,6-dihydrouracil + NAD(+) <=> H(+) + NADH + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197963", "l": "DHFR2 reduces FOLA to DHF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.945916858897462", "identifiers": [{"i": "GO:0008378", "l": "galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid."]}, {"i": "REACT:R-HSA-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72671", "l": "eIF5B:GTP is hydrolyzed and released (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28391", "l": "N(6)-(D-psicosyl)-L-lysine => N(6)-(D-fructosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74615", "l": "UDP-alpha-D-galactose(in) + UDP-alpha-D-glucose(out) = UDP-alpha-D-galactose(out) + UDP-alpha-D-glucose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30727", "l": "dATP + pyruvate = dADP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785594", "l": "FANCD2 binds FANCI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58464", "l": "a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44341", "l": "(S)-2,3-diaminopropanoate + ATP + fumarate => AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61817", "l": "16,17-didehydropregnenolone + UDP-alpha-D-glucose => 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050537", "l": "mandelamide amidase activity", "d": ["Catalysis of the reaction: (R)-mandelamide + H2O = (R)-mandelate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199093", "l": "CXADR binds to AMICA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204813", "l": "Interaction of Tie2 and Grb14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24147", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA <=> 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34962", "l": "(R)-carnitine(in) <=> (R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047898", "l": "formate dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: formate + ferricytochrome b1 = CO2 + ferrocytochrome b1."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050464", "l": "nitrate reductase (NADPH) activity", "d": ["Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23755", "l": "all-trans-undecaprenol + ATP <=> ADP + all-trans-undecaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938930", "l": "RUNX1 binds ELF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682769", "l": "LGI2 binds ADAM22,23 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5323526", "l": "FRAT proteins bind GSK3beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20434", "l": "NAD(+) + xylitol => D-xylulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20489", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)", "d": []}, {"i": "EC:2.3.2.11", "l": "\"alanylphosphatidylglycerol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388830", "l": "PI3K binds ICOS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944219", "l": "Association of procollagen type XVI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24623", "l": "NAD(+) + octan-1-ol <=> H(+) + NADH + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730840", "l": "Activation of RAC1 by VAV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32666", "l": "5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine <=> 5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6802973", "l": "PLK3 phosphorylates CDC25C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761421", "l": "CDH11 associates with catenins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028598", "l": "Phosphorylation of YAP by LATS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60378", "l": "D-glucose(in) => D-glucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38867", "l": "uridine(516) in 16S rRNA = pseudouridine(516) in 16S rRNA", "d": []}, {"i": "EC:5.4.99.19", "l": "\"16S rRNA pseudouridine(516) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20909", "l": "3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44418", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49740", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate = CO2 + deoxyviolacein + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046714", "l": "borate binding", "d": ["Binding to borate, the anion (BO3)3-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14479", "l": "a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0032296", "l": "double-stranded RNA-specific ribonuclease activity", "d": ["Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55730", "l": "19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate => 19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432520", "l": "CLK:CYC heterodimer binds to cwo gene and activates transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696605", "l": "USP12, USP26 deubiquitinate AR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696605", "l": "USP12, USP26 deubiquitinate AR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047166", "l": "1-alkenylglycerophosphoethanolamine O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810937", "l": "Lamellar bodies bind the early cornified envelope (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31692", "l": "(9Z,12Z)-octadecadienoate + O2 => (9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37073", "l": "2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine => [sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77094", "l": "Formation of cap binding complex (CBC) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71021", "l": "L-phenylalanine(in) + L-valine(out) => L-phenylalanine(out) + L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798373", "l": "MDM2 ubiquitinates DYRK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74588", "l": "(2E,6E)-farnesyl diphosphate => (+)-exo-beta-bergamotene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163310", "l": "TFAM binds to mitochondrial promoters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21112", "l": "globoside Gb3Cer (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose", "d": []}, {"i": "EC:3.2.1.22", "l": "\"alpha-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31062", "l": "H2O + imidazole-4-acetaldehyde + NAD(+) <=> 2 H(+) + imidazole-4-acetate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821410", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483089", "l": "PE is converted to PS by PTDSS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68595", "l": "ORC2 binds ORC3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74689", "l": "2 5'-deoxyadenosine + A + a macrocyclic archaeaol phospholipid + 2 H(+) + 2 L-methionine => a 2,3-di-O-phytanyl-sn-glycerophospholipid + AH2 + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63039", "l": "H2O + octadecanamide <=> NH4(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20126", "l": "H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018770", "l": "6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity", "d": ["Catalysis of the reaction: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2Z,4Z,7-trienoate + H2O = 2-(4'-chlorophenyl)-3,3-dichloropropenoate + cis-2-Hydroxy-3-chloropenta-2,4-dienone + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52698", "l": "a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676133", "l": "CD74 binds MIF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36302", "l": "(E)-caffeate + ATP + CoA <=> (E)-caffeoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67119", "l": "N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388808", "l": "CD28 homodimer binds B7-2 monomer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690404", "l": "Expression of SOX9 in testis differentiation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654569", "l": "Activated FGFR1 binds FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56274", "l": "4 Fe(II)-[cytochrome cL] + formate + 5 H(+) => 4 Fe(III)-[cytochrome cL] + H2O + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22760", "l": "Cypridina luciferin + O2 = CO2 + hnu + oxidized Cypridina luciferin", "d": []}, {"i": "EC:1.13.12.6", "l": "\"Cypridina-luciferin 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13025", "l": "3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = 3-methyl-(2E)-glutaconyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33573", "l": "AH2 + formaldehyde => A + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009072", "l": "STAT3 phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33811", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine = 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42420", "l": "2-oxoglutarate + L-lysine + O2 = (4R)-4-hydroxy-L-lysine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32690", "l": "(2E)-geranyl diphosphate <=> diphosphate + tricyclene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.139845358389962", "identifiers": [{"i": "GO:0004519", "l": "endonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43791", "l": "acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O <=> ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26230", "l": "3 NADP(+) + phytyl diphosphate => geranylgeranyl diphosphate + 3 H(+) + 3 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622738", "l": "CAT gene expression is stimulated by FOXO3,FOXO6,(FOXO1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140691", "l": "RNA folding chaperone", "d": ["Binding to an RNA or an RNA-containing complex to assist the folding process."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14200", "l": "ATP + L-aspartate + NH4(+) <=> ADP + H(+) + L-asparagine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38582", "l": "dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase] <=> (20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67163", "l": "chloride + FADH2 + melleolide F + O2 <=> 6'-chloromelleolide F + FAD + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59995", "l": "H(+) + oxidized [electron-transfer flavoprotein] + phloretate <=> (E)-4-coumarate + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74773", "l": "3,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine => 3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.4", "l": "\"malate dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30408", "l": "hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] => oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388503", "l": "Oxytocin receptor bind oxytocin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11567", "l": "4-O-beta-D-glucopyranosyl-D-gluconate + phosphate <=> alpha-D-glucose 1-phosphate + D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33723", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193669", "l": "TRAF6 binds to p75NTR:NRIF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672969", "l": "Phosphorylation of RAF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45772", "l": "[(1->4)-beta-D-mannosyl](n) + phosphate = [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": []}, {"i": "EC:2.4.1.319", "l": "\"beta-1,4-mannooligosaccharide phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357432", "l": "AXL binds SRC-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19344", "l": "2 H(+) + O2 + octane + 2 reduced [rubredoxin] <=> H2O + octan-1-ol + 2 oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73203", "l": "D-glucose(out) + H(+)(in) = D-glucose(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20643", "l": "3 H(+) + L-histidine + 2 NADH => H2O + L-histidinol + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197698", "l": "Src phosphorylate WASP,N-WASP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45616", "l": "H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61685", "l": "glycero-2-phosphocholine + H2O => glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14026", "l": "H(+) + H2O + sepiapterin => NH4(+) + xanthopterin-B2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20714", "l": "(8S)-8-amino-7-oxononanoate + CO2 + CoA => 6-carboxyhexanoyl-CoA + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11095", "l": "NAD(+) + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64848", "l": "(3Z)-hex-3-en-1-ol + benzoyl-CoA = (3Z)-hex-3-en-1-yl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45197", "l": "5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein] => 5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806831", "l": "CYB5Rs reduce MetHb to HbA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54390", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69443", "l": "3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) <=> 3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015271", "l": "outward rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59301", "l": "3'-phosphoadenylyl sulfate + firefly D-luciferin => adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857555", "l": "EGFR phosphorylates GPNMB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38463", "l": "a 1-acyl-sn-glycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67297", "l": "(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 => (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732527", "l": "FFAR1 binds rosiglitazone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45226", "l": "(2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA => (3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35634", "l": "cyanidin + UDP-alpha-D-galactose <=> cyanidin 3-O-beta-D-galactoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66397", "l": "ATP + cholate(in) + glutathione(in) + H2O => ADP + cholate(out) + glutathione(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5323526", "l": "FRAT proteins bind GSK3beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25302", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)", "d": []}, {"i": "EC:3.6.1.67", "l": "\"dihydroneopterin triphosphate diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37335", "l": "5,6-dihydrothymine + H2O = 3-(carbamoylamino)-2-methylpropanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65084", "l": "asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29808", "l": "ATP + H2O + L-leucine(out) => ADP + H(+) + L-leucine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32329", "l": "H(+) + NADH + zerumbone => 10-hydroxy-alpha-humulene + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687465", "l": "MRN complex binds RBBP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17495", "l": "AH2 + dihydroxyacetone => A + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5138432", "l": "DVL2 is phosphorylated by PKC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549129", "l": "OCT1 transports organic cations into hepatic cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44267", "l": "eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2981040", "l": "COLEC12:ligand is endocytosed (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60797", "l": "2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2 => 3 CO2 + gibberellin A20 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72681", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+) => (R)-dihydrolipoate + ATP + L-lysyl-[lipoyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46894", "l": "3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate => 2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11962", "l": "(S)-2-succinylamino-6-oxoheptanedioate + L-glutamate => 2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31661", "l": "5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine => beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69858", "l": "a 5,6-dihydrouridine in mRNA + NADP(+) <=> a uridine in mRNA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.69", "l": "\"glycosphingolipid deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61965", "l": "a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42278", "l": "(4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA => (2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.-", "l": "\"Transaminases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371590", "l": "HSP70 binds to HSP40:nascent protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111956", "l": "Calmodulin activates Cam-PDE 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70347", "l": "bromide + L-tyrosine + NADP(+) = 3-bromo-L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40940", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH => 1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005068", "l": "transmembrane receptor protein tyrosine kinase adaptor activity", "d": ["The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38638", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54519", "l": "8-hydroxycopalyl diphosphate <=> (13R)-manoyl oxide + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428917", "l": "G13 activation by TP receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28383", "l": "H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine => D-glucose 6-phosphate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018794", "l": "RHOV binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58935", "l": "4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH <=> 5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43331", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2029471", "l": "Hydrolysis of PC to PA by PLD (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24722", "l": "H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 = H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51730", "l": "dihydroxyacetone + phosphate => dihydroxyacetone phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5632677", "l": "PTCH is internalized (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70510", "l": "dimethylallyl diphosphate + H2O <=> dimethylallyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703439", "l": "FLT3 fusions recruit PIK3R1 through phosphorylated GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098695", "l": "inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels", "d": ["Any inositol 1,4,5-trisphosphate receptor activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25230", "l": "L-arabinitol + NADP(+) => H(+) + L-arabinose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68611", "l": "Formation of ORC(1-5) complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731924", "l": "EDNRA binds EDNs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670619", "l": "Defective ATRX does not bind DAXX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036081", "l": "extracellular ammonia-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54378", "l": "diphosphate + nezukol => (+)-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050033", "l": "L-rhamnono-1,4-lactonase activity", "d": ["Catalysis of the reaction: L-rhamnono-1,4-lactone + H2O = L-rhamnonate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22681", "l": "dCTP + H(+) + H2O => dUTP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22202", "l": "(E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trans-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48777", "l": "O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10732", "l": "ATP + firefly D-luciferin + O2 = AMP + CO2 + diphosphate + firefly oxyluciferin + hnu", "d": []}, {"i": "EC:1.13.12.7", "l": "\"firefly luciferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63383", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50745", "l": "2 glyphosate + O2 => 2 aminomethylphosphonate + 2 glyoxylate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57907", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008710", "l": "8-amino-7-oxononanoate synthase activity", "d": ["Catalysis of the reaction: L-alanine + H+ + pimelyl-CoA = 8-amino-7-oxononanoate + CO2 + CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140985", "l": "G protein-coupled chemorepellent receptor activity", "d": ["Combining with a chemorepellent and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417908", "l": "P2RY1 binds ADP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47126", "l": "H2O + N-hexacosanoylglycine => glycine + hexacosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16704", "l": "17alpha-estradiol + NAD(+) <=> estrone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22057", "l": "hexadecan-1-ol + NAD(+) => H(+) + hexadecanal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38787", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956568", "l": "RUNX1 binds the core TAL1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950387", "l": "CANX binds EBI3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77068", "l": "Activation of GT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29501", "l": "(+)-alpha-barbatene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76114", "l": "4-methylumbelliferone beta-D-glucuronate + H2O <=> 4-methylumbelliferone + D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15952", "l": "(R)-2-hydroxyoctadecanoate + NAD(+) <=> 2-oxooctadecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72743", "l": "leukotriene C4(out) = leukotriene C4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56617", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene => 1,2,4-trichlorobenzene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19204", "l": "2'-deoxyguanosine + ATP <=> ADP + dGMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10101", "l": "a sterol ester + H2O => a fatty acid + a sterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004092", "l": "carnitine O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.70", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871260", "l": "YAP1 binds TEAD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57949", "l": "2-hydroxytoluene + H(+) + NADH + O2 => 3-methylcatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34858", "l": "2 H2O + iminodiacetonitrile <=> N-(cyanomethyl)glycine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912408", "l": "Telomeres cluster at the nuclear membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64642", "l": "lactose + N-acetylneuraminate => H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197958", "l": "FPGS-2 transforms THF to THFPG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33892", "l": "chanoclavine-I + NAD(+) => chanoclavine-I aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36235", "l": "1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055054", "l": "fructose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose + H+ = fructose + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388817", "l": "ICOS binds ICOSL/B7-H2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46322", "l": "3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2 => 3beta-hydroxy-chol-5-ene-24-oyl-CoA + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190263", "l": "FGFR3b binds to FGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141423", "l": "Binding of the MCC complex to the APC/C complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11584", "l": "L-ornithine = D-ornithine", "d": []}, {"i": "EC:5.1.1.12", "l": "\"ornithine racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917987", "l": "TFRC dimer binds 2xholoTF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.232", "l": "\"initiation-specific alpha-1,6-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40781", "l": "L-2-aminopentanoate + NH4(+) => 2-aminopentanenitrile + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23177", "l": "acetate + ATP + CoA => acetyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199935", "l": "MSK1 activates CREB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376419", "l": "Formation of NR-MED1 Coactivator Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928619", "l": "PAK1 binds RAC1:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683801", "l": "CHEK2 phosphorylates BRCA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34739", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine = H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53008", "l": "(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = di-trans,poly-cis-polyprenyl diphosphate + n diphosphate", "d": []}, {"i": "EC:2.5.1.87", "l": "\"ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41934", "l": "H(+) + hexadecanoate + holo-[ACP] => H2O + hexadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1470010", "l": "Dimerization of STATs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38075", "l": "2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807872", "l": "Active ARF recruits coatomer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32682", "l": "(2E)-geranyl diphosphate + H2O <=> (2E)-geraniol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24231", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) <=> 4-methylcatechol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53298", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH => (2E)-decenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33564", "l": "(4R)-hydroxysphinganine + ATP => (4R)-hydroxysphinganine 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710354", "l": "GSDME (1-270) binds cardiolipin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088298", "l": "FOXM1 stimulates CCNB1 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75850", "l": "Addition of the third nucleotide on the nascent transcript (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52625", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72916", "l": "D-fructopyranose(out) + Na(+)(out) => D-fructopyranose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47923", "l": "ganglioside GM2 (d18:1(4E)/18:0) + H2O <=> ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71955", "l": "glutarate(out) + 3 Na(+)(out) = glutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18696", "l": "a penicillin + H2O <=> 6-aminopenicillanate + a carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676926", "l": "Methionine sulfoxide is oxidised to methionine sulfone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641206", "l": "RSPOs bind LGRs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428883", "l": "Recruitment of CAP to ABL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685604", "l": "SLAMF6 binds SLAMF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25675", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24958", "l": "(R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate => H2O + N-acetyl-beta-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33527", "l": "acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol = CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64883", "l": "CDP + H2O <=> CMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26494", "l": "chloride + FADH2 + L-tryptophan + O2 = 7-chloro-L-tryptophan + FAD + 2 H2O", "d": []}, {"i": "EC:1.14.19.9", "l": "\"tryptophan 7-halogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42304", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40810", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211904", "l": "CYP4F12 18-hydroxylates ARA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168935", "l": "viral dsRNA binds DDX58 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20682", "l": "cis-zeatin + UDP-alpha-D-glucose => H(+) + O-beta-D-glucosyl-cis-zeatin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37450", "l": "O2 + tetracenomycin F1 <=> H(+) + H2O + tetracenomycin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20840", "l": "H(+) + L-histidine = CO2 + histamine", "d": []}, {"i": "EC:4.1.1.22", "l": "\"histidine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16666", "l": "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O => (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390141", "l": "D inhibits WTS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50212", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.10", "l": "\"crossover junction endodeoxyribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70734", "l": "4-aminobutanoate(out) + chloride(out) + 3 Na(+)(out) <=> 4-aminobutanoate(in) + chloride(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43484", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018422", "l": "GDP-mannose:serine-protein mannose-1-phosphotransferase activity", "d": ["Catalysis of the transfer of mannose-1-phosphate to a serine residue in a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46840", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404142", "l": "atROL binds RBP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215295", "l": "USP7 deubiquitinates MDM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532549", "l": "MPI isomerises Fru6P to Man6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789325", "l": "Expression of IL13-downregulated extracellular proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9669854", "l": "KIT binds type II TKIs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49432", "l": "cholate + lithocholoyl-CoA = choloyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69548", "l": "H(+) + O-phospho-L-serine = CO2 + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21037", "l": "2 acetyl-CoA => acetoacetyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004423", "l": "iduronate-2-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604328", "l": "AKT1 phosphorylates NOTCH4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66858", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate => (2E)-geranyl diphosphate + 3 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448963", "l": "Interaction of MyoD:E protein with MEF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69127", "l": "Formation of the Flap Intermediate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140618", "l": "ferric-chelate reductase (NADH) activity", "d": ["Catalysis of the reaction: 2 Fe3+-siderophore + NAD+ + H+ -> 2 Fe2+-siderophore + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57483", "l": "2-hydroxydodecanoate + H2O2 <=> 2,3-dihydroxydodecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50215", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20653", "l": "23,24-dihydrocucurbitacin B + NAD(+) = cucurbitacin B + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16603", "l": "fumarate + NH4(+) => L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42284", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9794444", "l": "ALB binds Cipro (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199404", "l": "CD40L binds CD40 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37840", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18843", "l": "2-hydroxy-3-oxopropanoate + H(+) + NADPH => (R)-glycerate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42258", "l": "3-oxooctanoyl-[ACP] + CO2 + CoA => H(+) + hexanoyl-CoA + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109700", "l": "AKT2 binds PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951951", "l": "RUNX3 binds EP300 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016497", "l": "substance K receptor activity", "d": ["Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250264", "l": "TXNIP binds reduced thioredoxin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306876", "l": "NLRP3 activation by small molecules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33176", "l": "4-hydroxyphenylacetate(in) => 4-hydroxyphenylacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419003", "l": "Interaction of Nectins with Afadin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067659", "l": "Assembly of hexameric IL-6 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420883", "l": "Opsins act as GEFs for G alpha-t (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38976", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23697", "l": "myo-inositol + O2 => D-glucuronate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33914", "l": "an N-alkylglycine + H2O + O2 <=> an alkylamine + glyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034536", "l": "2-hydroxy-8-methylchromene-2-carboxylate isomerase activity", "d": ["Catalysis of the reaction: 2-hydroxy-8-methylchromene-2-carboxylate = 2-hydroxy-3-methylbenzalpyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53656", "l": "(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 = (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854466", "l": "VLDLR binds RELN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050405", "l": "[acetyl-CoA carboxylase] kinase activity", "d": ["Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67672", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25293", "l": "ethanol + NAD(+) <=> acetaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68504", "l": "(2Z,6Z)-farnesyl diphosphate = (Z)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11717", "l": "a monoamide of a dicarboxylate + H2O => a dicarboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38923", "l": "a ubiquinone + H(+) + Na(+)(in) + NADH = a ubiquinol + Na(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102817", "l": "caffeoyl-CoA:3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) 3'-O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + caffeoyl-CoA <=> gentiodelphin + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33770", "l": "a 3-hydroxy-fatty acyl-CoA <=> a (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57136", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18389", "l": "alpha-D-xylose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-xylose", "d": []}, {"i": "EC:2.7.7.11", "l": "\"UTP--xylose-1-phosphate uridylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49310", "l": "a neolactoside nLc4Cer(d18:0) + L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12125", "l": "4-coumaroyl-CoA + shikimate => CoA + trans-4-coumaroylshikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11953", "l": "3-hydroxypyruvate => 2-hydroxy-3-oxopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19014", "l": "dTTP + H2O => dTDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787525", "l": "TRMT61B methylates adenosine-58 in tRNA yielding 1-methyladenosine-58 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614544", "l": "Sulfite is oxidized to sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66373", "l": "H2O + sn-glycerol 3-phosphate => glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9612509", "l": "SGK phosphorylates SRF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50661", "l": "3-(3-methylsulfanyl)propylmalate => 2-(2-methylsulfanyl)propylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27464", "l": "D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-D-glycero-alpha-D-manno-heptose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50502", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein] => acetyl-CoA + N-terminal L-alanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11085", "l": "3-dehydro-L-gulonate + H(+) => CO2 + L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43076", "l": "erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26096", "l": "(4R)-limonene + H(+) + NADH + O2 <=> H2O + limonene 1,2-epoxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37493", "l": "CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine => 4-coumaroyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8987214", "l": "p-STAT3 dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65938", "l": "beta-D-glucose => beta-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37045", "l": "ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate => ATP + H2O + L-alanyl-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64309", "l": "3-aminobutanoate + pyruvate => acetoacetate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008962", "l": "phosphatidylglycerophosphatase activity", "d": ["Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192051", "l": "CYP7A1 7-hydroxylates CHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626938", "l": "Beta-catenin binds SOX proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612278", "l": "ERBB4s80 binds SPARC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140700", "l": "3',2'-cyclic GMP-AMP synthase activity", "d": ["Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(2'-5') (cyclic 3',2' GAMP)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50651", "l": "2-(2-methylsulfanyl)ethylmalate <=> 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21372", "l": "H(+) + H2O + urethane = CO2 + ethanol + NH4(+)", "d": []}, {"i": "EC:3.5.1.75", "l": "\"urethanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0033919", "l": "glucan 1,3-alpha-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32157", "l": "adenine + epoxyqueuosine(34) in tRNA + 2 H(+) + L-methionine => 7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22398", "l": "glycolaldehyde + guaiacol + H2O + vanillin => 1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051506", "l": "ergosterol UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + ergosterol = UDP + O-glucosyl-ergosterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43922", "l": "(25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38845", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20291", "l": "acetate + CoA + H(+) => acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651773", "l": "LIG1 binds POLB at long-patch BER site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20339", "l": "(R)-lactate + H(+) + sulfate => (R)-2-O-sulfolactate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667965", "l": "ANKLE2 binds PP2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39178", "l": "(3R)-hydroxyeicosanoyl-CoA <=> (2E)-eicosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018421", "l": "UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity", "d": ["Catalysis of the transfer of N-acetylglucosamine-1-phosphate to a serine residue in a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73635", "l": "CTP(out) + dGMP(in) = CTP(in) + dGMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050294", "l": "steroid sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3858475", "l": "ppDVL recruits RAC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19047", "l": "(3R)-citramalate + CoA + H(+) => acetyl-CoA + H2O + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59762", "l": "apigenin 7-O-beta-D-glucoside + H(+) + UDP => apigenin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070819", "l": "menaquinone-dependent protoporphyrinogen oxidase activity", "d": ["Catalysis of the reaction: protoporphyrinogen IX + menaquinone = protoporphyrin IX + reduced menaquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9006870", "l": "IL21 receptor STAT phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27409", "l": "3 a menaquinone + protoporphyrinogen IX = 3 a menaquinol + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0003917", "l": "DNA topoisomerase type I (single strand cut, ATP-independent) activity", "d": ["Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004173", "l": "ecdysone O-acyltransferase activity", "d": ["Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74446", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667456", "l": "AVPR1A,B bind desmopressin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102540", "l": "D-mannose 6-phosphate 1-epimerase activity", "d": ["Catalysis of the reaction: alpha-D-mannose 6-phosphate = beta-D-mannose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51384", "l": "hexadecanoyl-CoA + serotonin = CoA + H(+) + N-hexadecanoyl-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953037", "l": "E2F8 forms homodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173739", "l": "Spontaneous hydrolysis of C3 thioester (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16960", "l": "3',5'-cyclic GMP + H2O <=> GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69220", "l": "a (Z)-glucosinolate + H2O = a (Z)-N-(sulfonatooxy)alkanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15167", "l": "glyoxylate + H2O2 + methylamine => H2O + O2 + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66149", "l": "2-phenylethylamine + acetyl-CoA => CoA + H(+) + N-(2-phenylethyl)acetamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50598", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4] => acetyl-CoA + N-terminal L-seryl-[histone H4]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50133", "l": "ethyl hexadecanoate + H2O => ethanol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30177", "l": "9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9 => 15-cis-phytoene + 2 plastoquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44897", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30211", "l": "2 Fe(III)-[cytochrome c] + H2O + nitrous oxide = 2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide", "d": []}, {"i": "EC:1.7.2.5", "l": "\"nitric-oxide reductase (cytochrome c)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39751", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.72", "l": "\"Delta(24)-sterol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24676", "l": "ADP + CMP + H(+) => ATP + cytidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22661", "l": "a fatty acid + ATP + holo-[ACP] => a fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50429", "l": "methanethiol + S-adenosyl-L-methionine => dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45144", "l": "3-(methylsulfanyl)acryloyl-CoA + 2 H2O = acetaldehyde + CO2 + CoA + methanethiol", "d": []}, {"i": "EC:4.2.1.155", "l": "\"methylthioacryloyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28285", "l": "(S)-beta-bisabolene <=> (S)-beta-macrocarpene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47606", "l": "CMP + ganglioside GP1calpha (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44392", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222411", "l": "Peroxynitrite oxidizes Peptide-Methionine residues (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607722", "l": "Active NIK phosphorylates IKKA dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60693", "l": "(E)-non-2-enal + H2O + NADP(+) => (E)-non-2-enoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689085", "l": "ATXN3 binds polyUb-PARK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033464", "l": "GGG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GGG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.44", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24741", "l": "(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9716947", "l": "ESR1 binds ESR1 agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811454", "l": "MAPKs phosphorylate PP2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56169", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788867", "l": "FN3K phosphorylates ketosamines (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16086", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58165", "l": "(2E,6E)-farnesyl diphosphate + 2 H2O => 7-epi-ent-eudesmane-5,11-diol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3247836", "l": "Retromer recycles WLS to the Golgi (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803063", "l": "RNASEs bind bacterial LPS, PGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44528", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48691", "l": "H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine <=> D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16743", "l": "a 1,2-diacylglycerol + CoA => a 2-acylglycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70956", "l": "H(+)(in) + L-glutamate(in) => H(+)(out) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170964", "l": "FRS2 binds to active TrkA receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32967", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O = a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65107", "l": "aculene D + L-prolyl-[peptidyl-carrier protein] <=> aculene B + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63490", "l": "NADP(+) + phenanthrene-9,10-diol => 9,10-phenanthroquinone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22495", "l": "H2O + N-formimidoyl-L-glutamate <=> formamide + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65206", "l": "(R)-3-hydroxybutanoate + CoA + H(+) => (3R)-3-hydroxybutanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35303", "l": "3-hydroxyisopentadecanoyl-CoA + NADP(+) = 3-oxoisopentadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62136", "l": "dGMP + GTP = dGDP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60138", "l": "a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate => a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47573", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E)) => CMP + ganglioside GT1b (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46859", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH <=> 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9689680", "l": "IFNG dimer binds IFNG inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72338", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + syringate <=> 3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33548", "l": "H2O + lanosteryl hexadecanoate => H(+) + hexadecanoate + lanosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65600", "l": "4,5,8-trihydroxycasbene + 2 NAD(+) = 2 H(+) + jolkinol C + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56520", "l": "Fe-coproporphyrin III + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine", "d": []}, {"i": "EC:1.3.98.6", "l": "\"AdoMet-dependent heme synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29198", "l": "(S)-dihydroorotate + a menaquinone <=> a menaquinol + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805103", "l": "AURKA phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15507", "l": "2-formylglutarate + H(+) + NADH => (S)-2-hydroxymethylglutarate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689544", "l": "UCHL5 binds INO80 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64141", "l": "an N-(fatty acyl)-L-asparagine + H2O => a fatty acid + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46932", "l": "2-epi-5-epi-valiolone 7-phosphate = 5-epi-valiolone 7-phosphate", "d": []}, {"i": "EC:5.1.3.35", "l": "\"2-epi-5-epi-valiolone 7-phosphate 2-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27528", "l": "(2E,6E)-farnesol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693148", "l": "BCKDK phosphorylates BCKDH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38025", "l": "6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol => gamma-tocotrienol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70932", "l": "chloride(out) + dopamine(out) + 2 Na(+)(out) => chloride(in) + dopamine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.125", "l": "\"sucrose--1,6-alpha-glucan 3(6)-alpha-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70905", "l": "(2R)-3-phosphoglycerate + 2-deoxy-alpha-D-ribose 1,5-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + 2-deoxy-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13705", "l": "alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine = alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.138", "l": "\"mannotetraose 2-alpha-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41715", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75244", "l": "acetyl-CoA + N-terminal L-leucyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-leucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168885", "l": "Haptoglobin binds Hemoglobin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9761421", "l": "CDH11 associates with catenins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34551", "l": "ATP + cob(II)yrinate c monoamide + H2O + L-glutamine = ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12631", "l": "(6S)-6-hydroxyhyoscyamine + CO2 + succinate => 2-oxoglutarate + L-hyoscyamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28753", "l": "dihydroxyacetone phosphate + ubiquinol-8 => sn-glycerol 3-phosphate + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34823", "l": "(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O = CO2 + 2 CoA + curcumin", "d": []}, {"i": "EC:2.3.1.217", "l": "\"curcumin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33048", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] => (+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61375", "l": "4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O <=> 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042163", "l": "interleukin-12 beta subunit binding", "d": ["Binding to the beta subunit of interleukin-12."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080106", "l": "7-methylthiopropyl glucosinolate S-oxygenase activity", "d": ["Catalysis of the reaction: 7-methylthiopropyl-glucosinolate = 7-methylsulfinylpropyl-glucosinolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75820", "l": "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050170", "l": "peptidyl-glutaminase activity", "d": ["Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033433", "l": "AUU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AUU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202164", "l": "Translocation of PDK1 to Plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36442", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73190", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate <=> (2R,3S,11R)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754130", "l": "CDK4 inhibitors bind CDK4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043731", "l": "6-hydroxynicotinate 3-monooxygenase activity", "d": ["Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444523", "l": "CXCR5 binds CXCL13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-532549", "l": "MPI isomerises Fru6P to Man6P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18042", "l": "2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin] => 8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9646685", "l": "Aggresome dissociates from dynein and microtubule (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62434", "l": "a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine => a uridine in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52872", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804955", "l": "ATM phosphorylates MDM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36683", "l": "hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]", "d": []}, {"i": "EC:2.3.1.225", "l": "\"protein S-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65313", "l": "an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] => a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73773", "l": "H(+) + 2 H2O + neoechinulin A + oxidized [NADPH--hemoprotein reductase] => O2 + preechinulin + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65555", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O <=> an N-acyl-sphingoid base + lactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400023", "l": "Gq alpha activates Phospholipase C beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850534", "l": "PDCL promotes G-protein beta 5 folding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22975", "l": "butanal + CoA + NADP(+) <=> butanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61630", "l": "1-piperideine + H2O => 5-aminopentanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30620", "l": "2 A + all-trans-zeta-carotene => 2 AH2 + all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2485111", "l": "Collagen type III degradation by MMP10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877884", "l": "RUNX1 and FOXP3 stimulate the RSPO3 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42536", "l": "uridine(65) in tRNA = pseudouridine(65) in tRNA", "d": []}, {"i": "EC:5.4.99.26", "l": "\"tRNA pseudouridine(65) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63181", "l": "NADPH + 2 O2 => H(+) + NADP(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54490", "l": "1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672973", "l": "MAP2Ks phosphorylate MAPKs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13065", "l": "ATP + H2O = ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218855", "l": "BCAR1 binds p-7Y-PTK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917841", "l": "Acidification of Tf:TfR1 containing endosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47165", "l": "4alpha-carboxyzymosterol + NAD(+) => CO2 + NADH + zymosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43152", "l": "adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.220", "l": "\"tRNA (adenine(58)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25260", "l": "N-acetyl-D-glucosamine 6-phosphate <=> N-acetyl-D-mannosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216043", "l": "Collagen type II binds integrin alpha10beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70137", "l": "28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042007", "l": "interleukin-18 binding", "d": ["Binding to interleukin-18."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710106", "l": "ELANE cleaves GSDMD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67132", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH = (1S,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9732629", "l": "PPARG binds PPARG agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12100", "l": "1,5-anhydro-D-fructose = H2O + microthecin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45247", "l": "(3E,5Z)-octadienoyl-CoA <=> (2E,4E)-octadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735151", "l": "Expression of ISL1 in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-517674", "l": "p-S158,221-HuR binds mRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111237", "l": "Formation of ADAR1 homodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635424", "l": "Rv3364c binds cathepsin G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61845", "l": "solasodine + UDP-alpha-D-glucose => H(+) + solasodine 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9676264", "l": "Formation of the SET1B complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9671145", "l": "DKC1 binds SHQ1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56374", "l": "3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+) => 3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58510", "l": "(2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => (3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33121", "l": "(+)-sativene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13609", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.150", "l": "\"1-phosphatidylinositol-3-phosphate 5-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047281", "l": "dioxotetrahydropyrimidine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: pyrophosphate + a 2,4-dioxotetrahydropyrimidine D-ribonucleotide = PRPP + a 2,4-dioxotetrahydropyrimidine."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0061920", "l": "protein propionyltransferase activity", "d": ["Catalysis of the reaction: propionyl-CoA + lysine in peptide = CoA + N-propionyl-lysine-peptide."]}, {"i": "RHEA:54020", "l": "L-lysyl-[protein] + propanoyl-CoA = CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018814", "l": "RHOT1 hydrolyzes GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55215", "l": "(2R)-hydroxyhexadecanoyl-CoA <=> formyl-CoA + pentadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60951", "l": "(S)-eriodictyol + S-adenosyl-L-methionine <=> (S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033901", "l": "ribonuclease V activity", "d": ["Catalysis of the hydrolysis of poly(A), forming oligoribonucleotides and ultimately 3'-AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64616", "l": "(E)-coniferol + acetyl-CoA = (E)-coniferyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40684", "l": "1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol => 1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46636", "l": "5beta-dihydrotestosterone + NADP(+) = H(+) + NADPH + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23791", "l": "acetate + ATP + holo-[citrate lyase ACP] <=> acetyl-[citrate lyase ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57286", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA => a guanosine in RNA + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442586", "l": "Activation of WASP and N-WASP by CDC42 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473584", "l": "Collagen type III degradation by MMP15 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390035", "l": "HPO dimer autophosphorylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3321883", "l": "MSL acetylates histone H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58716", "l": "FADH2-C4alpha-hydroperoxide + NADH + rifampicin = FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63365", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2 => (S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65131", "l": "1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75722", "l": "CoA-disulfide + H2O <=> 4'-phosphopantetheinyl-CoA disulfide + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31399", "l": "all-trans-4,4'-diapophytofluene + FAD + H(+) = all-trans-4,4'-diapo-zeta-carotene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912369", "l": "NOTCH precursor cleaved to form mature NOTCH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16637", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.16", "l": "\"chitin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629679", "l": "PDE3A inhibitors bind PDE3A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948775", "l": "MKRN1 polyubiquitinates PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850786", "l": "SPINK6 binds KLK12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1011598", "l": "DOCKs bind to RhoGEFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937792", "l": "RUNX3 binds SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56384", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 = (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55615", "l": "an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + H2O <=> 1-methyladenine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099621", "l": "undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity", "d": ["Catalysis of the reaction: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose + ditrans,octacis-undecaprenyl phosphate = UDP + 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183051", "l": "CBL ubiquitinates Sprouty (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75228", "l": "H2O + L-xylono-1,4-lactone => H(+) + L-xylonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781905", "l": "ZRANB1 binds APC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34724", "l": "15-methylhexadecasphing-4-enine 1-phosphate + H2O => 15-methylhexadecasphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53492", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)", "d": []}, {"i": "EC:2.1.1.86", "l": "\"tetrahydromethanopterin S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061863", "l": "microtubule plus end polymerase", "d": ["Catalysis of the transfer of tubulin dimers to the plus end of a microtubule. The reaction is reversable depending on the availability of dimers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909718", "l": "Formation of p-STAT1 homodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132283", "l": "Factor H binds to host cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15579", "l": "D-ribose + uracil => H2O + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46253", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58437", "l": "4-methylpentan-1-ol + NADP(+) => 4-methylpentanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42710", "l": "N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine => guanosine(46) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49442", "l": "(R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate => (R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22996", "l": "H2O2 + L-ascorbate = 2 H2O + L-dehydroascorbate", "d": []}, {"i": "EC:1.11.1.11", "l": "\"L-ascorbate peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051921", "l": "adenosylcobyric acid synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: 4 L-glutamine + adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O = 4 L-glutamate + adenosylcobyrate + 4 ADP + 8 H+ + 4 phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818937", "l": "MEN1 binds MLL1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32913", "l": "sn-glycerol 3-phosphocholine(in) => sn-glycerol 3-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19380", "l": "NADP(+) + reduced riboflavin <=> 2 H(+) + NADPH + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606839", "l": "Steryl sulfatase hydrolyses sulfate from steroid sulfates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29281", "l": "H2O + menaquinone-8 + trimethylamine => H(+) + menaquinol-8 + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53555", "l": "(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45279", "l": "12-phosphooxy-(9E)-octadecenoate + H2O <=> 12-hydroxy-(9E)-octadecenoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35449", "l": "H(+) + NADPH + norsolorinic acid => (1'S)-averantin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102849", "l": "1-18:2-2-18:3-digalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:3-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0141051", "l": "histone H4K deacetylase activity", "d": ["Catalysis of the reaction: histone H4 N6-acetyl-L-lysine + H2O = histone H4 L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone H4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209823", "l": "Tyrosine is hydroxylated to dopa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66602", "l": "2 dopamine quinone + 2 H2O => 2 dopamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29145", "l": "a ubiquinone + 2 H(+)(out) + H2O + nitrite => a ubiquinol + 2 H(+)(in) + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202510", "l": "Activation of TAK1-TAB2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990460", "l": "leptin receptor binding", "d": ["Binding to a leptin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626928", "l": "CREBBP binds FOXO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12443", "l": "H2O + L-saccharopine + NAD(+) <=> 2-oxoglutarate + H(+) + L-lysine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005173", "l": "stem cell factor receptor binding", "d": ["Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9609310", "l": "β-blockers bind ADRB1,2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250962", "l": "botG LC cleaves target cell VAMP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17364", "l": "3-oxo-3-ureidopropanoate + H2O <=> H(+) + malonate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42601", "l": "AH2 + prostaglandin G2 => A + H2O + prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876789", "l": "CARNMT1 methylates CARN to Anserine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.102", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981931", "l": "RAC1 and CDC42 activate PAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11129", "l": "4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA => 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33645", "l": "(9Z)-tetradecenoyl-CoA + AMP + diphosphate => (9Z)-tetradecenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350058", "l": "Formation of CSL NCOR corepressor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62382", "l": "1-naphthol + CO2 + methylamine => carbaryl + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17903", "l": "H(+) + S-adenosyl-L-homocysteine + xanthotoxin => S-adenosyl-L-methionine + xanthotoxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855164", "l": "IP6 transports from the cytosol to the ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52994", "l": "[deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine => [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389381", "l": "Gads binds CD28 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44704", "l": "a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69633", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66167", "l": "butanoyl-CoA + serotonin <=> CoA + H(+) + N-butanoylserotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373724", "l": "Nephrin binds NCK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45867", "l": "16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202947", "l": "Caspase mediated cleavage of APC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66867", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + quiannulatene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26034", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.218", "l": "\"morphine 6-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72018", "l": "acetyl-CoA + 2 AH2 + 9 H(+) + malate + 6 malonyl-CoA + 5 NADPH + 2 S-adenosyl-L-methionine <=> 2 A + 6 CO2 + 7 CoA + 6 H2O + 5 NADP(+) + 2 S-adenosyl-L-homocysteine + trihazone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75441", "l": "14-demethyleburicol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => eburicol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65455", "l": "ethanol + hexanoyl-CoA <=> CoA + ethyl hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374663", "l": "DCC interaction with Ezrin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032327", "l": "5-oxo-EPA, 15d-PGJ3 translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12910", "l": "2 Fe(II)-[cytochrome] + 2 H(+) + nitrate => 2 Fe(III)-[cytochrome] + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392064", "l": "G alpha (z) inhibits adenylate cyclase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50958", "l": "H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216988", "l": "Monoubiquitination of PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68914", "l": "DNA polymerase alpha:primase binds at the origin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165195", "l": "GTP loading by Rheb (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708327", "l": "ANG cleaves tRNA to yield tRNA halves (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34476", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate => 15-cis-phytoene + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5579084", "l": "Defective AHCY does not hydrolyse AdoHcy (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32434", "l": "(1R,4S)-menthone + H(+) + NADPH + O2 <=> (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662608", "l": "MT2A binds cadmium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74936", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2 2-oxoglutarate + 2 O2 => (3R)-3-isocyanylbutanoate + 3 CO2 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004164", "l": "diphthine synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21528", "l": "[phosphate](n) + H2O = [phosphate](n-1) + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.11", "l": "\"exopolyphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14007", "l": "2-oxobutanoate + L-cysteine + NH4(+) => H2O + L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70683", "l": "(R)-normetanephrine + S-adenosyl-L-methionine = (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399988", "l": "AKT1 E17K mutant phosphorylates NR4A1 (NUR77) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195275", "l": "Phosphorylation of APC component of the destruction complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11089", "l": "H2O + trimetaphosphate => 2 H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183052", "l": "CBL binds to GRB2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102097", "l": "(22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity", "d": ["Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + O2 + NADPH + H+ <=> 3-dehydro-6-deoxoteasterone + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57232", "l": "GDP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106322", "l": "S-(hydroxymethyl)glutathione dehydrogenase NAD activity", "d": ["Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD+ = S-formylglutathione + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52689", "l": "3-phenyllactate + NAD(+) => 3-phenylpyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56101", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) => [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36576", "l": "(9Z)-octadecenoyl-CoA + sphinganine => CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684052", "l": "PIAS4 SUMOylates MDC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15066", "l": "H2O + N(4)-benzoylagmatine => agmatine + benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482773", "l": "MLCL transports from the IM to the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65991", "l": "previtamin D3 <=> calciol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047719", "l": "indole 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: indole + O2 = 2-formamidobenzaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42159", "l": "androsterone + H(+) + NADPH <=> 5alpha-androstane-3alpha,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27652", "l": "GDP + H(+) + UMP => GTP + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35112", "l": "2-dehydro-L-idonate + NADP(+) => 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757954", "l": "N4BP1 binds IKBKG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10695", "l": "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 <=> H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20295", "l": "3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH => 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19089", "l": "S-adenosyl-L-methionine + uroporphyrinogen III = H(+) + precorrin-1 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60973", "l": "hexan-1-ol + NAD(+) => H(+) + hexanal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34303", "l": "L-lysine = L-pipecolate + NH4(+)", "d": []}, {"i": "EC:4.3.1.28", "l": "\"L-lysine cyclodeaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47592", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) = CMP + ganglioside GP1c (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167408", "l": "The high affinity receptor complex binds to G-protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229132", "l": "AP4 binds APP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55214", "l": "formyl-CoA + pentadecanal => (2R)-hydroxyhexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19753", "l": "ATP + diphthine-[translation elongation factor 2] + NH4(+) = AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)", "d": []}, {"i": "EC:6.3.1.14", "l": "\"diphthine--ammonia ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56476", "l": "(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26467", "l": "a 2-demethylmenaquinone + S-adenosyl-L-methionine => a menaquinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204871", "l": "Interaction of Tie2 and Grb2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28313", "l": "beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.29", "l": "\"sulfinoalanine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052883", "l": "tyrosine ammonia-lyase activity", "d": ["Catalysis of the reaction: L-tyrosine = NH4 + trans-4-coumarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20450", "l": "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 => 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036175", "l": "ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor", "d": ["Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9656947", "l": "OGG1beta translocates to mitochondria (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.4", "l": "\"cellulase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27272", "l": "H(+) + hexadecanoyl-CoA + NADPH => CoA + hexadecanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73356", "l": "beta-alanyl-[peptidyl-carrier protein] + histamine => carcinine + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35818", "l": "4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) <=> 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40681", "l": "1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34493", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP => H2O + UDP-N,N'-diacetylbacillosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37475", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41949", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061787", "l": "peptidoglycan cross-bridge peptide endopeptidase activity", "d": ["A peptidoglycan endopeptidase activity that acts on a peptidoglycan cross-bridge."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870461", "l": "RABGGTA and RABGGTB bind (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64218", "l": "CO2 + L-lyxonate => 2-carboxy-L-lyxonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52088", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11642", "l": "an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH => a (2R,3R)-flavan-3-ol + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658104", "l": "SNCAIP binds alpha-synuclein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56105", "l": "2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 => 4,4'-diaponeurosporenal + 2 A + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71357", "l": "5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in) => 5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16246", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32348", "l": "2 S-adenosyl-L-methionine + tricetin => 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672957", "l": "PP2A dephosphorylates KSR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730856", "l": "Autophosphorylation of PAK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334827", "l": "SUMO-CRABP2 binds atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67322", "l": "sch 210971 => (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678854", "l": "S1PR1 binds S1PR1 agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193702", "l": "Part of the ICD migrates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34314", "l": "4-nitrocatechol + NADH + O2 <=> 2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83791", "l": "Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875591", "l": "DOCK7 activates RAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047906", "l": "fucosterol-epoxide lyase activity", "d": ["Catalysis of the reaction: (24R,24'R)-fucosterol epoxide = acetaldehyde + desmosterol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102813", "l": "UDP-D-glucose:cyanidin 3-(p-coumaroyl)-glucoside 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-(p-coumaroyl)-glucoside = shisonin + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41347", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061990", "l": "beta-ketodecanoyl-[acyl-carrier-protein] synthase activity", "d": ["Catalysis of the reaction: octanoyl-CoA + a malonyl-[acyl-carrier protein] = a 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62484", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183051", "l": "CBL ubiquitinates Sprouty (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2106614", "l": "Duplex miRNA is loaded into Argonaute (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209240", "l": "Activated phosphorylated TAK1 kinase phosphorylates and activates IRD5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769383", "l": "CBY1 binds beta-catenin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57795", "l": "3,4-dinitrotoluene + NADH + O2 <=> 4-methyl-6-nitrocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247839", "l": "Retromer associates with WLS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624798", "l": "LBR binds KPNB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44794", "l": "H(+) + menaquinol-12 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-12 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928604", "l": "SFKs phosphorylate VAV2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50729", "l": "(Z)-(4-hydroxyphenyl)acetaldehyde oxime => 4-hydroxyphenylacetonitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57951", "l": "2-hydroxytoluene + H(+) + NADH + O2 <=> 3-methylcatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10306", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP] => a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68740", "l": "7-oxocholesterol + H(+) + NADPH = 7alpha-hydroxycholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.23.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57431", "l": "anisole + O2 + reduced [NADH--hemoprotein reductase] <=> formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429860", "l": "DCP1-DCP2 complex decaps mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51705", "l": "S-adenosyl-L-methionine + xanthohumol => 4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17366", "l": "ATP + H2O + Mn(2+)(out) => ADP + H(+) + Mn(2+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34395", "l": "L-phenylalanine = L-beta-phenylalanine", "d": []}, {"i": "EC:5.4.3.10", "l": "\"phenylalanine aminomutase (L-beta-phenylalanine forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418553", "l": "cAMP degradation by Phosphodiesterases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45215", "l": "acetyl-CoA + Co(I)-[corrinoid Fe-S protein] + H(+) <=> CO + CoA + methyl-Co(III)-[corrinoid Fe-S protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170674", "l": "Dissociation of the Gi alpha:G olf complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21556", "l": "[calmodulin]-L-lysine + S-adenosyl-L-methionine = [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.60", "l": "\"calmodulin-lysine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917730", "l": "Cargo Recognition And Sorting (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20185", "l": "a CMP-N-acyl-beta-neuraminate + H2O = an N-acylneuraminate + CMP + H(+)", "d": []}, {"i": "EC:3.1.4.40", "l": "\"CMP-N-acylneuraminate phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46948", "l": "GTP + S-adenosyl-L-methionine = N(7)-methyl-GTP + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69066", "l": "H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline => N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176417", "l": "SMAD7:NEDD4L complex translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74538", "l": "2 AH2 + 2 archaetidylglycerol + 4 S-adenosyl-L-methionine <=> 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether glycerophospholipid + 4 H(+) + 4 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63969", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) => atromentin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0106050", "l": "tRNA 2'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing a 2'-O-nucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52567", "l": "2-dehydro-L-erythronate <=> 3-dehydro-L-erythronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374701", "l": "Phosphorylation of DCC by Fyn (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28425", "l": "(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0003922", "l": "GMP synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23983", "l": "cyclomaltodextrin + H2O <=> linear maltodextrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72103", "l": "Formation of pre-mRNPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65960", "l": "ATP + H2O + leukotriene C4(out) = ADP + H(+) + leukotriene C4(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72186", "l": "creatinine(in) + H(+)(out) <=> creatinine(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62181", "l": "H2O + peregrinol diphosphate => diphosphate + viteagnusin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26071", "l": "3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O <=> CoA + H(+) + phosphinomethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70216", "l": "cortisol + H(+) + NADPH => 20beta-dihydrocortisol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70455", "l": "(6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2", "d": []}, {"i": "EC:1.5.3.24", "l": "\"sarcosine oxidase (5,10-methylenetetrahydrofolate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757688", "l": "SERPINA6 binds PREDN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24621", "l": "NAD(+) + octan-1-ol => H(+) + NADH + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351876", "l": "Caspase-mediated cleavage of occludin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396007", "l": "IRF3 is phosphorylated by TBK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45996", "l": "a D-alpha-amino acid + a quinone + H2O = a 2-oxocarboxylate + a quinol + NH4(+)", "d": []}, {"i": "EC:1.4.5.1", "l": "\"D-amino acid dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14072", "l": "D-fructose + NADP(+) <=> 5-dehydro-D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28338", "l": "(R)-carnitinyl-CoA = crotonobetainyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.149", "l": "\"crotonobetainyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299482", "l": "TIMM23 SORT inserts proteins into inner membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30585", "l": "2-demethylmenaquinone-8 + H2O + trimethylamine => 2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382055", "l": "Grb7 binds to the active PDGF receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63053", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13097", "l": "a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O", "d": []}, {"i": "EC:4.2.1.59", "l": "\"3-hydroxyacyl-[acyl-carrier-protein] dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24579", "l": "diphosphate + H2O <=> H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733772", "l": "Expression of NKX2-5 in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66233", "l": "IC-asc-C7-CoA + O2 => H2O2 + IC-asc-DeltaC7-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75296", "l": "chloride(in) + sulfate(out) => chloride(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13456", "l": "3'-phosphoadenylyl sulfate + quercetin <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10534", "l": "D-glyceraldehyde 3-phosphate + H2O + L-tryptophan => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23541", "l": "ATP + L-glutamate + tRNA(Glu) => AMP + diphosphate + L-glutamyl-tRNA(Glu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052819", "l": "heteroglycan 2-alpha-mannosyltransferase activity", "d": ["Catalysis of the reaction: heteroglycan + GDP-mannose = (1->2)-alpha-D-mannosylheteroglycan + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0070643", "l": "vitamin D 25-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-25 of any form of vitamin D."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58063", "l": "2-sulfinoacetaldehyde + H2O <=> acetaldehyde + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247849", "l": "WLS dissociates from retromer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30403", "l": "Fe(3+)(out) + L-ascorbate(in) = Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": []}, {"i": "EC:7.2.1.3", "l": "\"ascorbate ferrireductase (transmembrane)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30299", "l": "2-oxoglutarate + a methylated nucleobase within DNA + O2 = a nucleobase within DNA + CO2 + formaldehyde + succinate", "d": []}, {"i": "EC:1.14.11.33", "l": "\"DNA oxidative demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.688704758796746", "identifiers": [{"i": "GO:0010333", "l": "terpene synthase activity", "d": ["Catalysis of the formation of cyclic terpenes through the cyclization of linear terpenes (e.g. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP) containing varying numbers of isoprene units."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29629", "l": "alpha-maltoheptaose + beta-D-glucose => alpha-maltohexaose + beta-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56108", "l": "genistein + O2 + reduced [NADPH--hemoprotein reductase] = 2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12921", "l": "glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO2 + CoA", "d": []}, {"i": "EC:2.3.1.37", "l": "\"5-aminolevulinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.-.-.-", "l": "\"Hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654422", "l": "Activated FGFR4 binds FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21267", "l": "A + glycolate <=> AH2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70421", "l": "3,4-dihydroxyphenylacetate + CoA + H(+) => 3,4-dihydroxyphenylacetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374667", "l": "DCC interaction with SIAH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948136", "l": "ULK1 Translocates to the mitochondria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852331", "l": "GTSE1 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32756", "l": "(2S)-naringenin + 2-oxoglutarate + O2 => apigenin + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10779", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) <=> 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17776", "l": "ATP + L-cysteine + tRNA(Cys) <=> AMP + diphosphate + L-cysteinyl-tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47256", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25987", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (5R)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22023", "l": "ATP + H2O + molybdate(out) <=> ADP + H(+) + molybdate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59899", "l": "ATP + L-glutamate + L-propargylglycine <=> ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.20.2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050067", "l": "lysine 2-monooxygenase activity", "d": ["Catalysis of the reaction: L-lysine + O2 = 5-aminopentanamide + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66932", "l": "(E)-4-coumaroyl-CoA + 5-hydroxyanthranilate = avenanthramide A + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374909", "l": "Metabolism of Noradrenaline (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22856", "l": "(7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA", "d": []}, {"i": "EC:2.3.1.150", "l": "\"salutaridinol 7-O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10341", "l": "(2E,6E)-farnesyl diphosphate => (-)-vetispiradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432054", "l": "Aquaporin-1 passively transports water out of cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51805", "l": "deoxyhumulone + dimethylallyl diphosphate => diphosphate + H(+) + lupulone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48728", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2464822", "l": "RDH12 reduces atRAL to atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21789", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29115", "l": "H(+) + menaquinone-8 + NADPH = menaquinol-8 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58917", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + squalene => (S)-2,3-epoxysqualene + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783880", "l": "PIPOX oxidises PPCA to P6C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16318", "l": "(S)-indan-1-ol + NAD(+) => H(+) + indan-1-one + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21970", "l": "3-dehydroquinate + phosphate => 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36311", "l": "3,4-dihydroxybenzaldehyde + H2O + NAD(+) = 3,4-dihydroxybenzoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002173", "l": "low-affinity IgM receptor activity", "d": ["Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381608", "l": "cAMP activates EPAC2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052869", "l": "arachidonic acid omega-hydroxylase activity", "d": ["Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45283", "l": "12-(phosphooxy)octadecanoate + H2O <=> 12-hydroxyoctadecanoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62643", "l": "[mycoredoxin]-L-dithiol + a hydroperoxide <=> [mycoredoxin]-L-disulfide + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.33", "l": "\"peptidyl-Asp metalloendopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.36", "l": "\"retinal dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83650", "l": "FasL:Fas binds FADD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031764", "l": "type 1 galanin receptor binding", "d": ["Binding to a type 1 galanin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102203", "l": "brassicasterol glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + brassicasterol <=> UDP(3-) + 3-O-beta-D-glucosyl-brassicasterol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35100", "l": "fusidate(in) + H(+)(out) => fusidate(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050311", "l": "sulfite reductase (ferredoxin) activity", "d": ["Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = sulfite + 3 reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0042296", "l": "ISG15 transferase activity", "d": ["Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages."]}, {"i": "REACT:R-HSA-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709787", "l": "SARS-CoV-1 9b binds TOMM70 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12958", "l": "an acetyl ester + H2O => acetate + an aliphatic alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015545", "l": "bicyclomycin transmembrane transporter activity", "d": ["Enables the transfer of bicyclomycin from one side of a membrane to the other. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15598", "l": "a Fe(III)-siderophore(out) + ATP + H2O => a Fe(III)-siderophore(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20445", "l": "L-arogenate + oxaloacetate = L-aspartate + prephenate", "d": []}, {"i": "EC:2.6.1.78", "l": "\"aspartate--prephenate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33077", "l": "6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine => 3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682598", "l": "ATM phosphorylates HERC2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22605", "l": "D-mannose => D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73577", "l": "CAD hexamer transforms L-Gln to CAP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31029", "l": "beta-D-glucopyranosyl trans-(+)-abscisate + UDP => 2-trans-(+)-abscisate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52814", "l": "(9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+) => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865182", "l": "OTUD7A hydrolyses K11diUb (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29892", "l": "ATP + H2O + L-histidine(out) => ADP + H(+) + L-histidine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067640", "l": "IL6 binds IL6R-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29754", "l": "acetoacetate(in) <=> acetoacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008718", "l": "D-amino-acid dehydrogenase activity", "d": ["Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15991", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH => (R)-mevalonate + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67838", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730892", "l": "Recruitment of VAV to p-SLP-76 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0003825", "l": "alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity", "d": ["Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798044", "l": "BTG2 binds CCR4-NOT complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632939", "l": "TP53 binds the PTEN promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710959", "l": "p-STAT1 dimer binds KPNA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9646468", "l": "mTORC1 binds RHEB:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38096", "l": "gamma-tocotrienol + S-adenosyl-L-methionine => alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175174", "l": "Association of Ku heterodimer with viral DNA ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61575", "l": "(11Z,14Z)-eicosadienoate + O2 <=> (15S)-hydroperoxy-(11Z,13E)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74134", "l": "malvidin + UDP-alpha-D-galactose <=> H(+) + malvidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24510", "l": "H(+) + NADPH + prostaglandin E2 => NADP(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990458", "l": "lipooligosaccharide binding", "d": ["Binding to lipooligosaccharide. Lipooligosaccharides (LOSs) are the major glycolipids expressed on mucosal Gram-negative bacteria."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004515", "l": "nicotinate-nucleotide adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28165", "l": "cytidine + GTP <=> CMP + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17698", "l": "pyridine + thiamine => 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20342", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose => 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9656947", "l": "OGG1beta translocates to mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665703", "l": "ERBB2 TMD/JMD mutants bind pertuzumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34753", "l": "ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate => ATP + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708457", "l": "HM13 cleaves HMOX1 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64173", "l": "L-altrarate => galactarate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0004535", "l": "poly(A)-specific ribonuclease activity", "d": ["Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31357", "l": "formaldehyde + H2O + methanethiol + NAD(+) => dimethyl sulfide + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663138", "l": "p-BMAL1:p-CLOCK,NPAS2 binds CCRN4L (NOCTURNIN) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948034", "l": "FGR binds LDL:LRP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48799", "l": "O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68954", "l": "H(+) + S-adenosyl-L-homocysteine + scoparone => isoscopoletin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24600", "l": "H2O + O2 + sulfite = H2O2 + sulfate", "d": []}, {"i": "EC:1.8.3.1", "l": "\"sulfite oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975866", "l": "MyD88 forms a complex with the activated TLR receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42239", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390329", "l": "Dephosphorylation of AKT by PP2A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8867613", "l": "PICALM binds R-SNAREs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390329", "l": "Dephosphorylation of AKT by PP2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004835", "l": "tubulin-tyrosine ligase activity", "d": ["Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43884", "l": "3-oxochol-4-en-22-oyl-CoA + NAD(+) = 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2471621", "l": "Endostatin degradation by cathepsins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63830", "l": "pyruvate + vanillylamine => L-alanine + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698008", "l": "FLT3 mutants:GRB2:p-Y-GAB2 binds PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164840", "l": "ADP and Pi bind to ATPase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12600", "l": "acetyl-CoA + phosphinothricin <=> CoA + H(+) + N-acetylphosphinothricin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877902", "l": "Activated AR binds RUNX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2317314", "l": "AKT binds PDPK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70151", "l": "6-deoxo-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-28-norcastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033824", "l": "alternansucrase activity", "d": ["Catalysis of the transfer of an alpha-D-glucosyl residue from sucrose to alternately the 6-position and the 3-position of the non-reducing terminal residue of an alpha-D-glucan, thus producing a glucan having alternating alpha-1,6- and alpha-1,3-linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61982", "l": "NADP(+) + ubiquinol-10 => H(+) + NADPH + ubiquinone-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692376", "l": "BCL2 binds BCL2 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047537", "l": "2-aminohexanoate transaminase activity", "d": ["Catalysis of the reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71078", "l": "L-arginine(in) + L-cystine(out) <=> L-arginine(out) + L-cystine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654404", "l": "Activated FGFR2 binds SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34223", "l": "6-hydroxypseudooxynicotine + A + H2O = 2,6-dihydroxypseudooxynicotine + AH2", "d": []}, {"i": "EC:1.5.99.14", "l": "\"6-hydroxypseudooxynicotine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16627", "l": "CoA + thioacetate => acetyl-CoA + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001873", "l": "polysaccharide immune receptor activity", "d": ["Combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35735", "l": "a (2R)-2-hydroxycarboxylate + NADP(+) = a 2-oxocarboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428535", "l": "Activation of RAC1 by SOS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015652", "l": "quaternary ammonium group:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605768", "l": "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371591", "l": "Trimerization of cytosolic HSF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050323", "l": "taurine dehydrogenase activity", "d": ["Catalysis of the reaction: A + H2O + taurine = AH(2) + NH4 + sulfoacetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194678", "l": "CYP51A1 demethylates LNSOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32356", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose => 2 H(+) + ternatin C5 + 2 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18767", "l": "a 1,2-diacyl-sn-glycerol + a sphingomyelin => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25182", "l": "acetyl-CoA + putrescine => CoA + H(+) + N-acetylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5334794", "l": "FABPs bind LCFAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42484", "l": "D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] = D-sorbitol 6-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.198", "l": "\"protein-N(pi)-phosphohistidine--D-sorbitol phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805059", "l": "CK2:FACT phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10807", "l": "(S)-allantoin <=> (R)-allantoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621571", "l": "CD209 binds ICAM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61274", "l": "2-oxopentanoate + H2O2 + NH4(+) => H2O + L-2-aminopentanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018584", "l": "2,4,5-trichlorophenoxyacetic acid oxygenase activity", "d": ["Catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1912394", "l": "NICD1 in complex with RBPJ (CSL) recruits MAML (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-448958", "l": "Nuclear translocation of p38 MAPK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867344", "l": "OMA1 hydrolyses OPA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62665", "l": "(2'R)-atrovenetin + S-adenosyl-L-methionine => deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35603", "l": "beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68252", "l": "L-tryptophan(in) + Na(+)(in) = L-tryptophan(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10576", "l": "CTP + H(+) + N-methylethanolamine phosphate = CDP-N-methylethanolamine + diphosphate", "d": []}, {"i": "EC:2.7.7.57", "l": "\"N-methylphosphoethanolamine cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71458", "l": "goralatide + H2O <=> L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32496", "l": "(2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51247", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33414", "l": "(S)-malyl N-acetyl-alpha-D-glucosaminide + H2O <=> (S)-malyl alpha-D-glucosaminide + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19564", "l": "androst-4-ene-3,17-dione + H(+) + NADPH + O2 <=> H2O + NADP(+) + testololactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692764", "l": "MAPK6 binds CCND3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.74", "l": "\"(+)-piperitol/(+)-sesamin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354060", "l": "Translocation of RIAM to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788611", "l": "HYKK phosphorylates 5HLYS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362549", "l": "Hh-Np traffics to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31809", "l": "alpha-guaiene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48581", "l": "[pyruvate, water dikinase]-phosphate + H(+) + phosphate => [pyruvate, water dikinase] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55388", "l": "(3R)-3-hydroxy-2,3-dihydrotabersonine + A = (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28260", "l": "cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP => cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68560", "l": "arsenate + D-glyceraldehyde 3-phosphate + NAD(+) = 1-arsono-3-phospho-D-glycerate + H(+) + NADH", "d": []}, {"i": "EC:1.2.1.107", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24290", "l": "(6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine => 5-formimidoyltetrahydrofolate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47462", "l": "(3Z)-dodecenoyl-CoA + acetyl-CoA => 3-oxo-(5Z-tetradecenoyl)-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22056", "l": "hexadecan-1-ol + NAD(+) = H(+) + hexadecanal + NADH", "d": []}, {"i": "EC:1.1.1.164", "l": "\"hexadecanol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25473", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + gamma-himachalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31003", "l": "(S)-2,3-epoxysqualene = germanicol", "d": []}, {"i": "EC:5.4.99.34", "l": "\"germanicol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679239", "l": "ULK complex translocates to the ER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0010326", "l": "methionine-oxo-acid transaminase activity", "d": ["Catalysis of the reaction: methionine + a 2-oxo acid = 2-oxo-4-methylthiobutanoate + an amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1013020", "l": "Activation of GIRK/Kir3 Channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.52", "l": "\"phosphoserine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50504", "l": "acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0044388", "l": "small protein activating enzyme binding", "d": ["Binding to a small protein activating enzyme, such as ubiquitin-activating enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40614", "l": "H2O + trihexanoylglycerol <=> 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-982765", "l": "Growth hormone forms dimers and oligomers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2328037", "l": "Fibrillin-1 binds integrins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626549", "l": "IQGAPs bind CALM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50970", "l": "inosine(37) in tRNA(Ala) + NH4(+) => adenosine(37) in tRNA(Ala) + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14996", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH <=> a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000399", "l": "RANBP2 SUMOylates SP100 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.76", "l": "\"poly(3-hydroxyoctanoate) depolymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696491", "l": "CNTF binds CNTFR complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24873", "l": "H2O + O-phospho-D-serine = D-serine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20610", "l": "2-dehydro-3-deoxy-D-arabinonate => glycolaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44746", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O => 4 H(+) + 4 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592371", "l": "Initial activation of proMMP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031829", "l": "type 4 serotonin receptor binding", "d": ["Binding to a type 4 serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24236", "l": "2 Fe(III)-[cytochrome c] + H2O + trimethylamine = 2 Fe(II)-[cytochrome c] + 3 H(+) + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27821", "l": "L-idonate + NAD(+) <=> 2-dehydro-L-idonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57026", "l": "D-xylulose 5-phosphate + dihydroxyacetone phosphate => apulose 4-phosphate + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74542", "l": "creatinine(in) <=> creatinine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75073", "l": "chloride(in) + Cs(+)(out) + 2 hydrogencarbonate(out) => chloride(out) + Cs(+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68012", "l": "H2O + hypoxanthine + O2 = H2O2 + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63269", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2 => 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27300", "l": "2 H(+) + NADH + phthalate => 2-formylbenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.23", "l": "\"beta-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35676", "l": "H(+) + L-serine + tetradecanoyl-CoA => 3-oxohexadecasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706319", "l": "Active FLT3 binds to SLA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9676268", "l": "Formation of the MLL4 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12850", "l": "H2O + O-phospho-L-seryl-[myosin light chain] => L-seryl-[myosin light chain] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9612219", "l": "ERBB4s80 binds to SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805730", "l": "SETD9 methylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57955", "l": "H(+) + NADH + O2 + phenol <=> catechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41630", "l": "cyclooctat-9-en-7-ol + diphosphate => geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17736", "l": "acetylenedicarboxylate + H(+) + H2O <=> CO2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265887", "l": "Binding of RPA heterotrimer to 3' double stranded DNA break (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50979", "l": "prostaglandin D2(out) <=> prostaglandin D2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57808", "l": "1-chloro-3-nitrobenzene + NADH + O2 = 3-chlorocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849085", "l": "ARHGAP35 binds RHOA:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67127", "l": "a hydroperoxide + L-cysteinyl-[protein] <=> an alcohol + S-hydroxy-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44494", "l": "3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36920", "l": "(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64889", "l": "ATP + holo-[ACP] + tetradecanoate => AMP + diphosphate + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53983", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9736953", "l": "FURIN translocates to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446391", "l": "Formation of the PINCH-ILK-parvin complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176298", "l": "Activation of claspin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357445", "l": "PAK1-3 dimer disassociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2895778", "l": "POU5F1 (OCT4), STAT3 bind the SALL4 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047579", "l": "4-hydroxymandelate oxidase activity", "d": ["Catalysis of the reaction: (S)-4-hydroxymandelate + H+ + O2 = 4-hydroxybenzaldehyde + CO2 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18851", "l": "a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954199", "l": "CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011289", "l": "ZSWIM8 binds ROBO3.1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56676", "l": "dihydroferuloyl-CoA + NADP(+) = (E)-feruloyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9006850", "l": "IL21 receptor JAK phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44436", "l": "a 1,2-diacylglycerol + a 1-acylglycerol = a triacylglycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21806", "l": "1D-myo-inositol 3-phosphate + ADP + H(+) => ATP + myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5096488", "l": "RRP8 binds RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36484", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA => (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45168", "l": "2 (E)-sinapoyl-CoA + spermidine = 2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine", "d": []}, {"i": "EC:2.3.1.248", "l": "\"spermidine disinapoyl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73972", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30039", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 = benzene-1,2,4-triol + CO2 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003828", "l": "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30304", "l": "(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16539", "l": "(9S,10S)-9,10-dihydroxyoctadecanoate + phosphate => (9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61215", "l": "myricetin + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35446", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose <=> an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42769", "l": "a (2S)-2-hydroxycarboxylate + NADP(+) => a 2-oxocarboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41416", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668904", "l": "Formation of the CTF18 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49860", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20019", "l": "5,10-methylenetetrahydromethanopterin + H(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56666", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50271", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174235", "l": "Association of Emi1 with Cdc20 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.80", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36513", "l": "(11Z)-3-oxoicosenoyl-CoA + CO2 + CoA => (9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17683", "l": "2-methyl-3-oxopropanoate + H(+) + NADH => 3-hydroxy-2-methylpropanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222237", "l": "SMYD2 methylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30274", "l": "2 (3,4-dimethoxyphenyl)methanol + H2O2 <=> 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46770", "l": "a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603905", "l": "Expression of NLRP3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052751", "l": "GDP-mannose hydrolase activity", "d": ["Catalysis of the reaction: GDP-mannose + H2O = GMP + mannose-1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71901", "l": "H(+) + N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide => 3',5'-cyclic GMP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30972", "l": "7,7',9,9'-tetra-cis-lycopene => all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72180", "l": "Cleavage of mRNA at the 3'-end (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72996", "l": "L-fucose(out) + 2 Na(+)(out) => L-fucose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033524", "l": "TYSND1 cleaves SCP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399711", "l": "Activation of Ca impermeable AMPA receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19405", "l": "acetyl-CoA + citrate = (3S)-citryl-CoA + acetate", "d": []}, {"i": "EC:2.8.3.10", "l": "\"citrate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41790", "l": "acetyl-[ACP] + CoA => acetyl-CoA + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632993", "l": "PTEN gene transcription is stimulated by TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40365", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20215", "l": "L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein] => L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39091", "l": "(2E)-decenedioyl-CoA + H2O = (3S)-hydroxydecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629237", "l": "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20276", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051741", "l": "2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-phytyl-1,4-benzoquinone + S-adenosyl-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418200", "l": "SRC-1 bound to ARRB2 is not activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156682", "l": "PLK1 phosphorylates NUDC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250264", "l": "TXNIP binds reduced thioredoxin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034825", "l": "tetralin ring-hydroxylating dioxygenase activity", "d": ["Catalysis of the reaction: tetralin + O2 + NADH + H+ = cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39549", "l": "(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59298", "l": "an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical => an N-acylglycine + 2 L-ascorbate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24748", "l": "2-aminobut-2-enoate + methanethiol => L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649735", "l": "Intrinsic nucleotide exchange on RAS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46567", "l": "acetyl-CoA + apo-[ACP] <=> acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65446", "l": "CoA + hexyl butanoate => butanoyl-CoA + hexan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54469", "l": "1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71533", "l": "guanine(in) => guanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26070", "l": "CoA + H(+) + phosphinomethylmalate => 3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13192", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O <=> 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43627", "l": "2-aminomalonate semialdehyde + H(+) <=> aminoacetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41439", "l": "(9Z)-octadecenoyl-CoA + cholesterol <=> cholesteryl (9Z-octadecenoate) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65431", "l": "deamido-NAD(+)(in) + NAD(+)(out) <=> deamido-NAD(+)(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201629", "l": "Caspase-mediated cleavage of Tau (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22581", "l": "(S)-4-hydroxy-2-oxopentanoate => (2Z)-2-hydroxypenta-2,4-dienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58865", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42458", "l": "zymosterol => 4alpha-methylzymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14905", "l": "5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine", "d": []}, {"i": "EC:2.4.2.14", "l": "\"amidophosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29320", "l": "H2O + sn-glycero-3-phosphoethanolamine => ethanolamine + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804762", "l": "TP53 forms homotetramers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850945", "l": "Casein kinase II phosphorylates PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21010", "l": "diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH => diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109701", "l": "PDPK1 binds PIP3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448951", "l": "Activation of p38 alpha/beta MAPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74555", "l": "(S)-malate(out) = (S)-malate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.124", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382053", "l": "Translocation of PDGF from ER to Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65283", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate <=> 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Ser-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592243", "l": "Expression of POLRMT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21613", "l": "D-gluconate => 2-dehydro-3-deoxy-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50014", "l": "2-methylpropane-1,2-diol + H2O + NADP(+) => H(+) + NADPH + O2 + tert-butanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046934", "l": "1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50454", "l": "prostaglandin E3 => prostaglandin H3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5681987", "l": "LC3 is cleaved by ATG4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035489", "l": "guanine/guanine mispair binding", "d": ["Binding to a double-stranded DNA region containing a G/G mispair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668904", "l": "Formation of the CTF18 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42479", "l": "2,2',3-trihydroxydiphenyl ether + H(+) + O2 <=> 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56493", "l": "hederagenin + O2 + reduced [NADPH--hemoprotein reductase] => gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29435", "l": "enterobactin(in) + H(+)(out) = enterobactin(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59897", "l": "ATP + L-glutamate + L-propargylglycine => ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102084", "l": "L-dopa O-methyltransferase activity", "d": ["Catalysis of the reaction: L-dopa + S-adenosyl-L-methionine <=> 3-O-methyldopa + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32272", "l": "(2R,3S)-3-isopropylmalate + NAD(+) => 4-methyl-2-oxopentanoate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211950", "l": "CYP24A1 24-hydroxylates CTL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55657", "l": "2 A + a carotenoid beta-end derivative => a carotenoid chi-end derivative + 2 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21536", "l": "(3S)-hydroxy-3-methylglutaryl-CoA = 3-methyl-(2E)-glutaconyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.18", "l": "\"methylglutaconyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5251942", "l": "Hikeshi binds HSP70s:ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64109", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63040", "l": "H2O + lovastatin = H(+) + lovastatin carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24228", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) = 4-methylcatechol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197963", "l": "DHFR2 reduces FOLA to DHF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49247", "l": "NAD(+) + resolvin E1 <=> 18-oxo-resolvin E1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507869", "l": "Aquaporins passively transport glycerol into cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56428", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74765", "l": "3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => rhamnetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12632", "l": "2-oxoglutarate + L-hyoscyamine + O2 <=> (6S)-6-hydroxyhyoscyamine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507870", "l": "Aquaporins passively transport water out of cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18802", "l": "(cis-prenyl)n-diphosphate + isopentenyl diphosphate => (cis-prenyl)(n+1)-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008948", "l": "oxaloacetate decarboxylase activity", "d": ["Catalysis of the reaction: oxaloacetate = pyruvate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686061", "l": "Nucleoprotein is ADP-ribosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017441", "l": "PPARG gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64051", "l": "(13Z)-docosenoyl-CoA + sphinganine <=> CoA + H(+) + N-(13Z-docosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322422", "l": "Beta-catenin recruits SMARCA4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57079", "l": "3-oxoisoapionate 4-phosphate + H2O <=> (2R)-3-phosphoglycerate + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433415", "l": "Activation of RAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3159253", "l": "MMAB adenosylates cob(I)alamin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53231", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052756", "l": "chitobiose phosphorylase activity", "d": ["Catalysis of the reaction: chitobiose + phosphate = N-acetyl-D-glucosamine + N-acetyl-alpha-D-glucosamine 1-phosphate. This reaction is the phosphorolysis of chitobiose, (GlcNAc)2, a dimer of beta-(1->4) linked glucosamine units."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35863", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47590", "l": "CMP + ganglioside GQ1c (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73797", "l": "FAICAR => IMP + H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624668", "l": "CEBPA binds CDKN1A (p21) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64595", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110311", "l": "POLZ extends translesion synthesis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46220", "l": "androst-5-en-3beta,17beta-diol + NAD(+) = 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693598", "l": "ATM phosphorylates NBN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875183", "l": "CBL monoubiquitinates activated MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732692", "l": "Triazenes produce DNA damage in the form of O6-methylguanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68914", "l": "DNA polymerase alpha:primase binds at the origin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71000", "l": "(S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47199", "l": "a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13103", "l": "H2O + trans-urocanate => 4-imidazolone-5-propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59728", "l": "(2R)-ethylmalonyl-CoA = (2S)-ethylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17849", "l": "(3R)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.55", "l": "\"3-hydroxybutyryl-CoA dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51586", "l": "crotonobetainyl-CoA + reduced [electron-transfer flavoprotein] => 4-(trimethylamino)butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419843", "l": "CALCA(83-119) binds CALCR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.15", "l": "\"(Kdo)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5591086", "l": "SERPINA5 binds activated protein C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30089", "l": "2-oxoglutarate + FADH2 => (S)-2-hydroxyglutarate + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112395", "l": "Abortive termination of elongation after arrest (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53170", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75187", "l": "2,5-dihydroxybenzoyl-CoA + H2O = 2,5-dihydroxybenzoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68819", "l": "(2Z,6E)-farnesyl diphosphate <=> (E)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0070696", "l": "transmembrane receptor protein serine/threonine kinase binding", "d": ["Binding to a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55202", "l": "2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine => 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021412", "l": "PBX1 gene expression is stimulated by NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20550", "l": "2 Fe(III)-[cytochrome c] + 2 thiosulfate => 2 Fe(II)-[cytochrome c] + 2 H(+) + tetrathionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33403", "l": "ATP + L-threonine = diphosphate + L-threonyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42925", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183052", "l": "CBL binds to GRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211224", "l": "Association of DFF40 with DFF45 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46532", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.16", "l": "\"linoleoyl-lipid Delta(12) conjugase (11E,13Z-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018127", "l": "NAD(P)-serine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: NAD(P)+ + L-serine = nicotinamide + N2-(ADP-D-ribosyl)-L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007686", "l": "RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11071", "l": "(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O <=> (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31497", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71508", "l": "(+)-alpha-tocopherol(out) => (+)-alpha-tocopherol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57062", "l": "acetate + ADP-D-ribose + H(+) => 2''-O-acetyl-ADP-D-ribose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.63", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74064", "l": "2-aminoisobutanoate(out) + L-alanine(in) => 2-aminoisobutanoate(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54968", "l": "hexadecanoyl phosphate + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950328", "l": "Expression of Peptidyl-prolyl cis-trans isomerase A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983259", "l": "Kinesins move along microtubules consuming ATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56589", "l": "a monosubstituted aliphatic (S)-hydroxynitrile => an aldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46252", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814094", "l": "ARL1:GTP binds ARFIP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60207", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709879", "l": "BIL scavenges O2.- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299297", "l": "Activation of THIK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71807", "l": "a 2'-deoxyguanosine in DNA + NAD(+) = an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70116", "l": "6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6813626", "l": "LEAP2 binds bacteria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16640", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine <=> [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9690461", "l": "FKBP1A binds tacrolimus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11232", "l": "3'-phosphoadenylyl sulfate + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + sulfate", "d": []}, {"i": "EC:3.6.2.2", "l": "\"phosphoadenylylsulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37875", "l": "aklanonate + S-adenosyl-L-methionine = methyl aklanonate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.288", "l": "\"aklanonic acid methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691167", "l": "CUL1, SKP1, FBXL5 bind (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-622415", "l": "RIP2 binds NEMO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43595", "l": "all-trans-zeaxanthin + O2 <=> (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851018", "l": "BTN2A1 binds DC-SIGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25912", "l": "A + H2O + quinolin-5-ol = 5-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36573", "l": "CoA + H(+) + N-(tetradecanoyl)-sphinganine => sphinganine + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66286", "l": "H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP => tomatidine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11631", "l": "a 2-oxocarboxylate + H(+) <=> an aldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17036", "l": "(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) <=> biphenyl-2,3-diol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58670", "l": "3-deoxyglucosone + H(+) + NADPH => 3-deoxyfructose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29655", "l": "L-cysteine(in) = L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106137", "l": "IkappaB kinase complex binding", "d": ["Binding to a IkappaB kinase complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16367", "l": "2 3,4,5-trihydroxybenzoate + H(+) => digallate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.4", "l": "\"N-acetylgalactosamine-6-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62355", "l": "H(+) + NADPH + notoamide E + O2 <=> H2O + NADP(+) + notoamide D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52660", "l": "an L-alpha-amino acid + ATP + holo-[ACP] = AMP + an L-alpha-aminoacyl-[ACP] + diphosphate", "d": []}, {"i": "EC:6.2.1.n2", "l": "\"amino acid--[acyl-carrier-protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46608", "l": "ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204798", "l": "Interaction of Tie2 and p85 of PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32124", "l": "citrate(in) + H(+)(in) => citrate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64627", "l": "(2E)-geraniol + acetyl-CoA <=> (2E)-geranyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222128", "l": "NOC2L binds TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59589", "l": "ATP + beta-alanine + L-ornithine => ADP + beta-alanyl-L-ornithine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45375", "l": "H2O + N-(9Z-octadecenoyl)-sphinganine <=> (9Z)-octadecenoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51610", "l": "(R)-lactate + 2-oxoglutarate => (R)-2-hydroxyglutarate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15026", "l": "S-adenosyl-L-methionine + xanthosine => 7-methylxanthosine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26519", "l": "3-hydroxypropanoyl-CoA => acryloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864595", "l": "TFAP2B homodimer binds YEATS4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736959", "l": "WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.20", "l": "\"chondroitin-sulfate-ABC endolyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40858", "l": "FAD + H(+) + undecanoyl-CoA <=> FADH2 + trans-2-undecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29353", "l": "Zn(2+)(out) => Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.89", "l": "\"arabinogalactan endo-beta-1,4-galactanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033190", "l": "solanapyrone synthase activity", "d": ["Catalysis of the cyclization of double bonds in prosolanapyrone II to form (-)-solanapyrone A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30649", "l": "CDP-1L-myo-inositol + diphosphate => 1D-myo-inositol 3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354060", "l": "Translocation of RIAM to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72930", "l": "O2 + proatranorin I + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin IV", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710101", "l": "CASP4, CASP5 cleave GSDMD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.66", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.17", "l": "\"[phosphorylase] phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030273", "l": "melanin-concentrating hormone receptor activity", "d": ["Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67278", "l": "2 H(+) + hexanoate + NADH => H2O + hexanal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176298", "l": "Activation of claspin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10692", "l": "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone", "d": []}, {"i": "EC:1.3.3.11", "l": "\"pyrroloquinoline-quinone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52853", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] => 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451900", "l": "IL2RB binds JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0004707", "l": "MAP kinase activity", "d": ["Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807008", "l": "PTPRJ dephosphorylates MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37124", "l": "sphing-4-enine + tetracosenoyl-CoA => CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48128", "l": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047881", "l": "estradiol 17-alpha-dehydrogenase activity", "d": ["Catalysis of the reaction: estradiol-17-alpha + NAD(P)+ = estrone + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16382", "l": "L-arabinitol + NAD(+) => H(+) + L-xylulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58797", "l": "a flavonol 7-O-beta-D-glucoside + malonyl-CoA => a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24012", "l": "gamma-tocopherol + S-adenosyl-L-methionine = (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29027", "l": "2 H(+)(in) + L-glutamate(in) = 2 H(+)(out) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202604", "l": "Formation of a heteromeric BMP receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378956", "l": "Luteinizing hormone is a heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56777", "l": "(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0016434", "l": "rRNA (cytosine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53458", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46265", "l": "an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65274", "l": "chrodrimanin H + H2O + NADP(+) => chrodrimanin C + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0071813", "l": "lipoprotein particle binding", "d": ["Binding to a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788061", "l": "Fibronectin degradation by ADAM8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1235070", "l": "Expression of Erythropoietin (EPO) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65153", "l": "(2S)-naringenin + UDP-alpha-D-glucose => (2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-500708", "l": "GRIK3 homomer binds glutamate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22055", "l": "A + H2O + NH4(+) <=> AH2 + H(+) + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176318", "l": "Loading of claspin onto DNA during replication origin firing (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781840", "l": "ERCC6 binds stalled RNA Pol II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57800", "l": "2,3-dinitrotoluene + NADH + O2 = 4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30394", "l": "4-methylsulfanyl-2-oxobutanoate + L-glutamine <=> 2-oxoglutaramate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29337", "l": "L-alanine + L-glutamate => H2O + L-alanyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14672", "l": "D-glyceraldehyde 3-phosphate + H2O + NADP(+) <=> (2R)-3-phosphoglycerate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46609", "l": "ATP + L-threonyl-[protein] => ADP + H(+) + O-phospho-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698007", "l": "FLT3 ITD mutants bind STAT5 through GAB2:PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47906", "l": "ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate => ATP + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791158", "l": "Expression of CXXC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4167511", "l": "HLCS biotinylates ACACB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41737", "l": "3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) => adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44649", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41952", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate", "d": []}, {"i": "EC:2.6.1.118", "l": "\"[amino group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.42903515889401", "identifiers": [{"i": "GO:0005496", "l": "steroid binding", "d": ["Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632652", "l": "Hh-Npp binds CDON and PTCH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24795", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592362", "l": "Activation of proMMP7 by MMP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693061", "l": "STAMBP binds STAM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454916", "l": "The ABCC family mediates organic anion transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193665", "l": "MYD88 dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21973", "l": "precorrin-1 + S-adenosyl-L-methionine => precorrin-2 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209840", "l": "Two DITs combine to form thyroxine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018129", "l": "peptidyl-oxazoline dehydrogenase activity", "d": ["Catalysis of the reduction of a peptide-linked oxazoline to oxazole."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57073", "l": "3-oxoisoapionate 4-phosphate + H(+) => CO2 + L-erythrulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30213", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide => 2 Fe(III)-[cytochrome c] + H2O + nitrous oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52407", "l": "3-dehydro-4-O-phospho-L-erythronate + H(+) <=> CO2 + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52307", "l": "H2O + L-ectoine <=> (2S)-2-acetamido-4-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159733", "l": "Furin cleaves pro-factor X to factor X (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45529", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68619", "l": "cortisone + H(+) + NADPH <=> cortisol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24156", "l": "2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP", "d": []}, {"i": "EC:2.7.2.14", "l": "\"branched-chain-fatty-acid kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32965", "l": "2-oxoglutarate + NH4(+) => 2-oxoglutaramate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39476", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA => (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691131", "l": "CANDI binds CUL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35542", "l": "cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 <=> albonoursin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.266", "l": "\"dTDP-4-dehydro-6-deoxyglucose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30613", "l": "AH2 + all-trans-neurosporene => A + all-trans-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29731", "l": "beta-maltose(in) = beta-maltose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295613", "l": "SPRY2 binds GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12287", "l": "3-hydroxy-3-methylglutarate + succinyl-CoA <=> (3S)-hydroxy-3-methylglutaryl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66996", "l": "2-methylpentanoate + ATP + CoA = 2-methylpentanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74697", "l": "(5R)-hydroxy-beta-trans-bergamotene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-exo-beta-bergamotene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605414", "l": "NOTCH4 binds SMAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67689", "l": "2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O => 2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60239", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72986", "l": "dimethylallyl diphosphate + harmol <=> 6-(3-dimethylallyl)harmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218642", "l": "PTK2 autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210430", "l": "Release of L-Glutamate at the synapse (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75753", "l": "10-hydroxyoctadecanoate => (9Z)-octadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23623", "l": "ATP + N(2)-(2-carboxyethyl)-L-arginine <=> AMP + deoxyamidinoproclavaminate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18151", "l": "acetate + D-galactosamine 6-phosphate => H2O + N-acetyl-D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.32", "l": "\"maleylacetate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15607", "l": "H(+) + NH4(+) + pyruvate + sulfate => H2O + L-serine O-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1248677", "l": "Inactivation of over-expressed wild type EGFR by Cetuximab recombinant antibody (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55356", "l": "11-cis-retinol = 13-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52074", "l": "(9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+) => 12-(9Z-hexadecenoyloxy)-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780995", "l": "NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634228", "l": "TRAF1 is cleaved by caspases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15681", "l": "2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) = (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.60", "l": "\"5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63783", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098601", "l": "selenomethionine adenosyltransferase activity", "d": ["Catalysis of the reaction: ATP + L-Selenomethionine + H2O => Orthophosphate + Diphosphate + Se-Adenosylselenomethionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38232", "l": "(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA => 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374680", "l": "L1 trans-homophilic interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12817", "l": "2,3-dihydrobiochanin A + NADP(+) = biochanin A + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.46", "l": "\"biochanin-A reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-870269", "l": "Gastrin binds to CCK-B receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10865", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 => 2-(acetamidomethylene)succinate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200858", "l": "Nef Binds and activates the Src-family tyrosine kinase Hck (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418200", "l": "SRC-1 bound to ARRB2 is not activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-83788", "l": "Binding of TFIIIC to Type 2 promoter (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48164", "l": "epoxypheophorbide a + H2O = H(+) + red chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003919", "l": "FMN adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + FMN = diphosphate + FAD."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187332", "l": "Cytosolic CMs translocate to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730886", "l": "Phosphorylation of SHC by SYK kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10228", "l": "citrate = cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983285", "l": "RAD51B binds RAD51C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70119", "l": "6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940134", "l": "FOLR2 binds FOLA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.41", "l": "\"isocitrate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60102", "l": "cyanidin 3-O-beta-D-glucoside + H(+) + UDP => cyanidin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21236", "l": "anthranilate + 2 H(+) + NADPH + O2 = 2,3-dihydroxybenzoate + NADP(+) + NH4(+)", "d": []}, {"i": "EC:1.14.13.35", "l": "\"anthranilate 3-monooxygenase (deaminating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49134", "l": "an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48489", "l": "all-trans-retinol--[retinol-binding protein] + NAD(+) => all-trans-retinal--[retinol-binding protein] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357472", "l": "PAK1-3 autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451895", "l": "IL2RG binds JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68610", "l": "Formation of ORC(2-5) complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43445", "l": "1,2-ditetradecanoyl-sn-glycerol + ATP => 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.75", "l": "\"glucan endo-1,6-beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49982", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine => H2O + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8856189", "l": "TNFSF8 binds TNFRSF8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54515", "l": "peregrinol diphosphate <=> (13R)-9,13-epoxylabd-14-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28419", "l": "(R)-carnitine + 4-(trimethylamino)butanoyl-CoA => (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74370", "l": "substance P(out) <=> substance P(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16464", "l": "ATP + H2O + urate(in) <=> ADP + H(+) + phosphate + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11785", "l": "H2O + L-aspartate + NADP(+) => H(+) + NADPH + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047213", "l": "anthocyanidin 3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37658", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035717", "l": "chemokine (C-C motif) ligand 7 binding", "d": ["Binding to chemokine (C-C motif) ligand 7."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56834", "l": "2,3,6-trichlorohydroquinone + 2 glutathione => 2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75092", "l": "2 chloride(in) + sulfate(out) => 2 chloride(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3341294", "l": "Superoxide reduces cytochrome c (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684052", "l": "PIAS4 SUMOylates MDC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731931", "l": "EDNRA binds selective ERAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177934", "l": "EGFR autophosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20570", "l": "H2O + L-arginine => L-ornithine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69623", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42810", "l": "3 reduced coenzyme F420-(gamma-L-Glu)(n) + sulfite => 2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050179", "l": "phenylserine aldolase activity", "d": ["Catalysis of the reaction: L-threo-3-phenylserine = benzaldehyde + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46341", "l": "ATP + N-hexadecanoylsphing-4-enine => ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70713", "l": "D-alanine(out) => D-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.3.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64307", "l": "1-phenylpropylamine + pyruvate <=> 1-phenylpropan-1-one + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033793", "l": "aureusidin synthase activity", "d": ["Catalysis of the reactions: 2',4,4',6'-tetrahydroxychalcone + O2 = aureusidin + H2O, and 2',3,4,4',6'-pentahydroxychalcone + 1/2 O2 = aureusidin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170799", "l": "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71720", "l": "H(+)(out) + L-methionyl-L-phenylalanyl-L-methionine(out) => H(+)(in) + L-methionyl-L-phenylalanyl-L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617462", "l": "HOXD1 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797269", "l": "Expression of HSPA8, ALOX15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64904", "l": "GTP + 2 H2O = GMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34842", "l": "4 H(+) + 5 malonyl-CoA <=> 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54969", "l": "hexadecanoyl phosphate + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71581", "l": "CDP(in) + CDP-L-ribitol(out) => CDP(out) + CDP-L-ribitol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15851", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + L-dehydroascorbate => 2 Fe(III)-[cytochrome c] + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419049", "l": "ROCK activation by RHO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22373", "l": "H2O + O2 + propionate 3-nitronate => 3-oxopropanoate + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75269", "l": "D-arabinono-1,5-lactone + H(+) + NADPH => D-arabinose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451506", "l": "TLR21homodimer binds to DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21447", "l": "3-(2-hydroxyphenyl)propanoate + NAD(+) <=> H(+) + NADH + trans-2-coumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46031", "l": "H2O2 + tetradecanoate <=> (2R)-hydroxytetradecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.184", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17767", "l": "(2R)-2,3-bisphosphoglycerate + H(+) => (2R)-3-phospho-glyceroyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28745", "l": "nitrate(out) + nitrite(in) => nitrate(in) + nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67768", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.76", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865320", "l": "CBFB binds RUNX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853793", "l": "p-5Y-RET complexes bind GRB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10051", "l": "methanethiol + O-acetyl-L-homoserine <=> acetate + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22201", "l": "S-adenosyl-L-methionine + trans-aconitate => (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68771", "l": "4 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022F + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236935", "l": "Proteasomal cleavage of substrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072551", "l": "diferuloyl mono-(hydroxyferuloyl) spermidine meta-hydroxylase activity", "d": ["Catalysis of the reaction: diferuloyl mono-(hydroxyferuloyl) spermidine + NADPH + O2 = monoferuloyl di-(hydroxyferuloyl) spermidine + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625091", "l": "FOXO1,FOXO3 bind ABCA6 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850961", "l": "PREX2 binds PTEN and inhibits it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71580", "l": "CDP(out) + CDP-L-ribitol(in) => CDP(in) + CDP-L-ribitol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23188", "l": "NAD(+) + propane-1,3-diol = 3-hydroxypropanal + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.202", "l": "\"1,3-propanediol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24005", "l": "butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55668", "l": "11-cis-retinol--[retinol-binding protein] + NAD(+) = 11-cis-retinal--[retinol-binding protein] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033974", "l": "nucleoside phosphoacylhydrolase activity", "d": ["Catalysis of the hydrolysis of mixed phospho-anhydride bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63761", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944233", "l": "Association of procollagen type XIX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58482", "l": "ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate => a cytidine in mRNA + acetyl-CoA + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050007", "l": "isonocardicin synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nocardicin E = S-methyl-5'-thioadenosine + H+ + isonocardicin A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60365", "l": "H(+)(out) + myo-inositol(out) => H(+)(in) + myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57151", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102541", "l": "D-galactose 6-phosphate 1-epimerase activity", "d": ["Catalysis of the reaction: alpha-D-galactose 6-phosphate = beta-D-galactose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8856945", "l": "PP2A methylation by LCMT1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44878", "l": "3-acyl-sn-glycerol + a fatty acid + H(+) => a 1,3-diacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16814", "l": "H2O + L-kynurenine => anthranilate + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22457", "l": "creatine + H2O => sarcosine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76456", "l": "O-atom dealkylation of dextromethorphan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912394", "l": "NICD1 in complex with RBPJ (CSL) recruits MAML (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684008", "l": "NBN binds KPNA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61869", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68855", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (1S,6S,7R)-sesquipiperitol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392749", "l": "Transport of L1 into endosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24612", "l": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47416", "l": "an NDP-alpha-D-glucose + D-glucose = a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18756", "l": "[protein]-dithiol + NADP(+) <=> [protein]-disulfide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3321805", "l": "NSL acetylates histone H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000122", "l": "CD320 binds extracellular TCN2:RCbl (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203070", "l": "Association of profilin with monomeric actin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25211", "l": "acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762246", "l": "ANGPTL4 binds CDH11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42379", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444433", "l": "Cho transports from the extracellular space to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44364", "l": "2-epi-5-epi-valiolone + ATP = 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.188", "l": "\"2-epi-5-epi-valiolone 7-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10420", "l": "pyruvate + taurine = L-alanine + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67263", "l": "(E)-hept-2-enal + H2O + NAD(+) <=> (E)-hept-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.033057138195133", "identifiers": [{"i": "GO:0008374", "l": "O-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086040", "l": "sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential", "d": ["Enables the transfer of a solute or solutes from one side of a cardiac muscle cell membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). This transfer contributes to the regulation of the cardiac muscle cell plasma membrane potential."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102212", "l": "unsaturated chondroitin disaccharide hydrolase activity", "d": ["Catalysis of the reaction: beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46440", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2 = A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O", "d": []}, {"i": "EC:1.14.19.14", "l": "\"linoleoyl-lipid Delta(9) conjugase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72777", "l": "ADP + H(+) + ochratoxin B + phosphate => 7-carboxymellein + ATP + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71296", "l": "chloride(out) + 2 Na(+)(out) + O-propanoyl-(R)-carnitine(out) => chloride(in) + 2 Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26558", "l": "(3S)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61857", "l": "dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2 => betaenone C + 3 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604732", "l": "Autocatalytic activation of proMMP13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34899", "l": "malonyl-CoA + S-adenosyl-L-methionine = malonyl-CoA methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74734", "l": "rhamnetin + S-adenosyl-L-methionine <=> 7,4'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052843", "l": "inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55228", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008475", "l": "Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190065", "l": "Activated TrkA receptor internalizes to endosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71902", "l": "3',5'-cyclic GMP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10977", "l": "H(+) + NADH + O2 + quinolin-2-ol => 5,6-dihydroquinoline-2,5,6-triol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.108", "l": "\"nocturnin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30006", "l": "alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose <=> alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52414", "l": "3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH => 4-phospho-D-erythronate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24388", "l": "phosphate + uridine = alpha-D-ribose 1-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36349", "l": "4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine => N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2090079", "l": "GLB1 hydrolyses linker chain(2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9609921", "l": "SGTA binds Tail-anchored protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853956", "l": "Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15587", "l": "4 AH2 + all-trans-lycopene => 15-cis-phytoene + 4 A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14810", "l": "phenol + S-adenosyl-L-methionine => anisole + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102272", "l": "homophytochelatin synthase activity (polymer-forming)", "d": ["Catalysis of the reaction: glutathionate + a poly gamma-glutamylcysteine-beta-alanine = glycine + a poly gamma-glutamylcysteine-beta-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40316", "l": "glutaryl-CoA + O2 => (2E)-glutaconyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65468", "l": "1-propanol + acetyl-CoA = CoA + propyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49684", "l": "H(+) + NADH + O2 + resorcinol = benzene-1,2,4-triol + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.220", "l": "\"resorcinol 4-hydroxylase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83788", "l": "Binding of TFIIIC to Type 2 promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190256", "l": "FGFR1c binds to FGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71719", "l": "H(+)(out) + L-methionyl-L-phenylalanyl-L-methionine(out) = H(+)(in) + L-methionyl-L-phenylalanyl-L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14611", "l": "H(+) + keto-L-sorbose + NADPH => D-sorbitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-351948", "l": "Mitochondrial recruitment of Drp1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693761", "l": "FA2H hydroxylates CERA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177922", "l": "EGFR dimerization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044588", "l": "laminaribiose binding", "d": ["Binding to laminaribiose, a disaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66613", "l": "N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA => methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400459", "l": "Signal peptidase hydrolyzes preproGLP-1 to proGLP-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62231", "l": "(E)-ascladiol + A <=> AH2 + patulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25032", "l": "ADP-alpha-D-ribose 1''-phosphate + H2O <=> ADP-D-ribose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376419", "l": "Formation of NR-MED1 Coactivator Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41567", "l": "aklavinone + dTDP-beta-L-rhodosamine <=> aclacinomycin T + dTDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17533", "l": "2-oxoglutarate + an aromatic L-alpha-amino acid = an aromatic oxo-acid + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33482", "l": "an acyl-CoA + lanosterol <=> CoA + lanosteryl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11883", "l": "(S)-6-hydroxynicotine + H2O + O2 <=> 6-hydroxypseudooxynicotine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37171", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38217", "l": "6-phospho-D-glucono-1,5-lactone + H(+) + NADH => D-glucose 6-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876472", "l": "NPC2 binds CHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.824318789188837", "identifiers": [{"i": "GO:0004721", "l": "phosphoprotein phosphatase activity", "d": ["Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46735", "l": "(2R,6)-dimethylheptanoyl-CoA <=> (2S,6)-dimethylheptanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34436", "l": "4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine => 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433451", "l": "JAK2 binds to p-KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10080", "l": "dihydrophloroglucinol + NADP(+) = 1,3,5-trihydroxybenzene + NADPH", "d": []}, {"i": "EC:1.3.1.57", "l": "\"phloroglucinol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972949", "l": "POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14487", "l": "10-epi-juneol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.11", "l": "\"tryptophan 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67880", "l": "3'-phosphoadenylyl sulfate + dopamine = adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56474", "l": "(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61099", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61096", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = (S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050415", "l": "formimidoylglutamase activity", "d": ["Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609921", "l": "SGTA binds Tail-anchored protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53278", "l": "17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373730", "l": "Neurofascin and NrCAM heterodimerization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41780", "l": "beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59003", "l": "H2O + O2 + propanal <=> H(+) + H2O2 + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48609", "l": "A + a 2,3-saturated acyl-CoA => a 2,3-dehydroacyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249386", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33054", "l": "choline + NAD(+) <=> betaine aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30955", "l": "9,9'-di-cis-zeta-carotene + 2 a quinone = 7,7',9,9'-tetra-cis-lycopene + 2 a quinol", "d": []}, {"i": "EC:1.3.5.6", "l": "\"9,9'-di-cis-zeta-carotene desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.27567501185726", "identifiers": [{"i": "GO:0030545", "l": "signaling receptor regulator activity", "d": ["Binds to and modulates the activity of a receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15454", "l": "S-adenosyl-L-methionine + sarcosine => H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54173", "l": "H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+) => 2''-O-acyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71950", "l": "N-acetyl-L-aspartate(out) + 3 Na(+)(out) <=> N-acetyl-L-aspartate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74586", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-glutamyl-[protein] <=> N-acetyl-L-cysteine + N-terminal L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047750", "l": "cholestenol delta-isomerase activity", "d": ["Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018791", "l": "2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity", "d": ["Catalysis of the reaction: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate = CO2 + 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693356", "l": "CEMIP hydrolyses HA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33107", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-muurolene", "d": []}, {"i": "EC:4.2.3.126", "l": "\"gamma-muurolene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.24", "l": "\"malyl-CoA lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804879", "l": "MDM2 ubiquitinates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602466", "l": "Activation of MT-MMPs by FURIN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9675026", "l": "Formation of the MLL1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.41", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75663", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate = 10,11-epoxy-12-hydroxy-(14Z)-eicosenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420233", "l": "VIP receptors bind VIP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16503", "l": "H(+) + myo-inositol + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29905", "l": "ADP + D-ribose(in) + H(+) + phosphate => ATP + D-ribose(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74182", "l": "a secondary alkyl amine + H2O + NADP(+) <=> a ketone + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052623", "l": "ADP dimethylallyltransferase activity", "d": ["Catalysis of the reaction: delta2-isopentenyl diphosphate + ADP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45446", "l": "H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate => H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54806", "l": "4,4'-disulfanyldibutanoate + H(+) + NADH => 2 4-sulfanylbutanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72547", "l": "2-oxoglutarate(in) + taurocholate(out) = 2-oxoglutarate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21035", "l": "glucuronate acceptor + UDP-alpha-D-glucuronate <=> acceptor beta-D-glucuronoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788061", "l": "Fibronectin degradation by ADAM8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70966", "l": "D-phenylalanine + H2O + O2 <=> 3-phenylpyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428918", "l": "Dissociation of the TP:G13 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55971", "l": "(+)-kolavelool + S-adenosyl-L-methionine <=> (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38176", "l": "all-trans-retinol + hexadecanoyl-CoA => all-trans-retinyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74953", "l": "(3R)-3-isocyanylbutanoate + 2 CO2 + 2 H2O + succinate => (3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0019784", "l": "deNEDDylase activity", "d": ["An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3244643", "l": "STING binds cyclic GMP-AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54304", "l": "n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate = n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56897", "l": "a carboxylate + ATP + H(+) => an acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703435", "l": "FLT3 fusions activate STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "57.067006135972647", "identifiers": [{"i": "GO:0016757", "l": "glycosyltransferase activity", "d": ["Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140951", "l": "histone H3K27 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl27-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl27-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682967", "l": "WHSC1 binds DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031884", "l": "type 1 member 1 taste receptor binding", "d": ["Binding to a type 1 member 1 taste receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37133", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140804", "l": "NAD+- protein-lysine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl-[protein] + NAD+ = H+ + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:58220", "l": "L-lysyl-[protein] + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57374", "l": "(6S)-NADPHX => H2O + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54874", "l": "(4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-menthone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514891", "l": "SLC24A1 exchanges 4Na+ for Ca2+, K+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56859", "l": "A + an aldehyde + H2O <=> a carboxylate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16002", "l": "H(+) + H2O + N(6)-methyl-AMP => IMP + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46897", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) => a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.1.1", "l": "\"transketolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844617", "l": "IPAF binds procaspase-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203977", "l": "SAR1 Activation And Membrane Binding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000319", "l": "sulfite transmembrane transporter activity", "d": ["Enables the transfer of sulfite ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39108", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798749", "l": "Exocytosis of specific granule lumen proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42547", "l": "uridine(32) in tRNA <=> pseudouridine(32) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030620", "l": "U2 snRNA binding", "d": ["Binding to a U2 small nuclear RNA (U2 snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55786", "l": "all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP => all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40134", "l": "(9Z)-hexadecenoyl-CoA + H2O <=> (9Z)-hexadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848776", "l": "PTK6 phosphorylates DOK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20918", "l": "hydrogen sulfide + L-cysteate => L-cysteine + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13448", "l": "(R)-pantetheine + H2O <=> (R)-pantothenate + cysteamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685606", "l": "CLEC2D binds KLRB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592362", "l": "Activation of proMMP7 by MMP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47482", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => deoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106377", "l": "2-hydroxy-ATP hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-ATP + H2O = 2-hydroxy-AMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65198", "l": "H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine => H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60877", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52383", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445079", "l": "Phosphorylation of L1 by ERK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030411", "l": "scytalone dehydratase activity", "d": ["Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55579", "l": "4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine <=> H(+) + psilocybin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60322", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70417", "l": "(3,5-dihydroxyphenyl)acetate + CoA + H(+) => (3,5-dihydroxyphenyl)acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66617", "l": "Mg(2+)(in) + 2 Na(+)(out) => Mg(2+)(out) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186819", "l": "SH2 domain of Src binds to the active receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8957241", "l": "TP73 tetramer translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9612509", "l": "SGK phosphorylates SRF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49526", "l": "a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685156", "l": "ATR phosphorylates RPA2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982017", "l": "Active G alpha (q) binds RGS proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047410", "l": "N-formylmethionylaminoacyl-tRNA deformylase activity", "d": ["Catalysis of the reaction: H2O + charged-fMet-tRNAs = L-methionylaminoacyl-tRNA + formate."]}]}
{"type": "biolink:MolecularActivity", "ic": "75.576939455547432", "identifiers": [{"i": "GO:0004197", "l": "cysteine-type endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63064", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + tetraacetate lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19631", "l": "2-oxoglutarate + CO2 + NADPH => D-threo-isocitrate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58876", "l": "4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047948", "l": "glutarate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + CoA + glutarate = ADP + glutaryl-CoA + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69970", "l": "Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) <=> Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198270", "l": "PDPK1 phosphorylates AKT at T308 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22249", "l": "7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) => 7,8-dihydroxykynurenate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50143", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004052", "l": "arachidonate 12(S)-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71643", "l": "guanosine + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452122", "l": "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102946", "l": "soyasapogenol E UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + soyasapogenol E <=> UDP + a soyasapogenol E monoglucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186819", "l": "SH2 domain of Src binds to the active receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031873", "l": "type 2 proteinase activated receptor binding", "d": ["Binding to a type 2 proteinase activated receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66783", "l": "6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O <=> N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434990", "l": "SEMA7A binds to integrin alpha1beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641134", "l": "SMURF2 binds AXIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.93", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388605", "l": "POMC(138-176) binds MC2R (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49930", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53337", "l": "5,6-dihydrouridine(20) in tRNA + NADP(+) => H(+) + NADPH + uridine(20) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21385", "l": "L-phenylalanine => (E)-cinnamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196929", "l": "FLAD1 phosphorylates FMN (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35880", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76031", "l": "2 H2O2 => O2 + 2 H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44365", "l": "2-epi-5-epi-valiolone + ATP => 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41483", "l": "an acyl-CoA + episterol <=> an episterol ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165179", "l": "Formation of TSC1:TSC2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22653", "l": "2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65095", "l": "asperaculane G + O2 + reduced [NADPH--hemoprotein reductase] <=> aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008874", "l": "gluconate 5-dehydrogenase activity", "d": ["Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700156", "l": "Active ALK dimer binds IRS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30626", "l": "A + all-trans-neurosporene <=> AH2 + all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18958", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036312", "l": "phosphatidylinositol 3-kinase regulatory subunit binding", "d": ["Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58994", "l": "(E)-cinnamate + H(+) + H2O2 => (E)-cinnamaldehyde + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036320", "l": "mating-type P-factor pheromone receptor activity", "d": ["Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66980", "l": "2-methylbutanoyl-CoA + H2O = 2-methylbutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168136", "l": "Activated JNKs phosphorylate c-JUN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50021", "l": "decanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047476", "l": "3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity", "d": ["Catalysis of the reaction: CoA + 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate + ATP = 3-alpha,7-alpha-dihydroxy-5-beta-cholestanoyl-CoA + diphosphate + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928627", "l": "EPHB phosphorylates TIAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31653", "l": "5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine => beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28947", "l": "H(+)(out) + L-arabinose(in) = H(+)(in) + L-arabinose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58364", "l": "a medium-chain primary fatty alcohol + NADP(+) = a medium-chain fatty aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380949", "l": "AMPK is dephosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47968", "l": "ganglioside GM2 + H2O = ganglioside GM3 + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084912", "l": "Arresten binds integrin alpha1beta1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445448", "l": "HHIP binds Hedgehog (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001631", "l": "cysteinyl leukotriene receptor activity", "d": ["Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47955", "l": "[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O <=> [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41223", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30120", "l": "dodecanoyl-[ACP] + H2O => dodecanoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22870", "l": "chloride + H(+) + S-carboxymethyl-L-cysteine => 3-chloro-L-alanine + thioglycolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433711", "l": "Cis-homodimerization of nectins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39112", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) => 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938389", "l": "RUNX1:CBFB binds the LGALS3 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174202", "l": "Degradation of multiubiquitinated Securin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33203", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848436", "l": "PTK6 phosphorylates CDKN1B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016913", "l": "follicle-stimulating hormone activity", "d": ["The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50865", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23544", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.240", "l": "\"flavonol-3-O-glycoside glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51420", "l": "a (2S,3S)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14225", "l": "6-hydroxyhexanoate + NAD(+) = 6-oxohexanoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.258", "l": "\"6-hydroxyhexanoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53352", "l": "5,6-dihydrouridine(20b) in tRNA + NAD(+) = H(+) + NADH + uridine(20b) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37108", "l": "H2O + N(7)-methyl-GMP => N(7)-methylguanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.651613913496419", "identifiers": [{"i": "GO:0019900", "l": "kinase binding", "d": ["Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9692880", "l": "HRH3 binds Hist (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177942", "l": "EGFR binds EGF ligand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31105", "l": "folate + H(+) + NADPH => 7,8-dihydrofolate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70268", "l": "hydrogencarbonate(in) + Na(+)(in) => hydrogencarbonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72660", "l": "NADPH + O2 + quinolin-8-ol => 8-hydroxyquinoline N-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2219524", "l": "PDPK1 binds PIP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031995", "l": "insulin-like growth factor II binding", "d": ["Binding to insulin-like growth factor II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24111", "l": "H2O + N-methyl-2-oxoglutaramate <=> 2-oxoglutarate + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15027", "l": "7-methylxanthosine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + xanthosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21827", "l": "2-oxoglutarate + L-aspartate <=> L-glutamate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031696", "l": "alpha-2C adrenergic receptor binding", "d": ["Binding to an alpha-2C adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34535", "l": "H(+) + hexadecanoyl-CoA + L-alanine = 1-deoxy-3-dehydrosphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55780", "l": "all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate = all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696146", "l": "AOC2 deaminates TYR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29607", "l": "H2O + NAD(+) + nitrous oxide = H(+) + NADH + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673223", "l": "FIX(29-461) variant is not activated (factor XIa catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55655", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33247", "l": "O2 + putrescine = 1-pyrroline + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66753", "l": "(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O => (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75971", "l": "NADP(+) + neomorphine = H(+) + NADPH + neomorphinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.11", "l": "\"neprilysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197690", "l": "Detachment of WASP/WAVE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65442", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51529", "l": "H(+) + vanillate => CO2 + guaiacol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62586", "l": "ADP + H(+) + L-tyrosine(in) + phosphate => ATP + H2O + L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57516", "l": "dolabradiene + O2 + reduced [NADPH--hemoprotein reductase] = 15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13101", "l": "4-imidazolone-5-propanoate = H2O + trans-urocanate", "d": []}, {"i": "EC:4.2.1.49", "l": "\"urocanate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50760", "l": "a quinone + H2O + sulfite = a quinol + sulfate", "d": []}, {"i": "EC:1.8.5.6", "l": "\"sulfite dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59685", "l": "D-maltohexaose + O2 => D-maltohexaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201608", "l": "Caspase-mediated cleavage of alpha adducin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55037", "l": "an N,N-dimethylornithine lipid + S-adenosyl-L-methionine => an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806629", "l": "Formation of tonofilament bundles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806613", "l": "Keratin tetramers bind to form unit length filaments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018572", "l": "EGFR phosphorylates NOTCH3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42077", "l": "2-hydroxyglutarate + acetyl-CoA => 2-hydroxyglutaryl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32384", "l": "(1S,2S,4R)-limonene-1,2-diol + NAD(+) => (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.202", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49394", "l": "20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18445", "l": "H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": []}, {"i": "EC:3.5.4.10", "l": "\"IMP cyclohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32515", "l": "(4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O = (3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13276", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol <=> 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981926", "l": "RAC1 and CDC42 activate PAK3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57911", "l": "ATP + L-glutamyl-tRNA(Gln) <=> 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64107", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein] <=> 1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28971", "l": "H(+)(in) + shikimate(in) = H(+)(out) + shikimate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24872", "l": "5'-deoxyadenosine + phosphate <=> 5-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8957241", "l": "TP73 tetramer translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102881", "l": "(+)-beta-barbatene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-beta-barbatene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102042", "l": "dehydroquinate synthase activity", "d": ["Catalysis of the reaction: 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonic acid + H2O + NAD = 3-dehydroquinate + ammonium + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445705", "l": "Release Of ADP From Myosin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332363", "l": "Autophosphorylation and activation of CAMK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49525", "l": "2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 => a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67336", "l": "kaempferol 3-O-beta-D-glucoside + malonyl-CoA = CoA + kaempferol 3-O-(6-O-malonyl-beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45277", "l": "12-phosphooxy-(9E)-octadecenoate + H2O => 12-hydroxy-(9E)-octadecenoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64358", "l": "(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O => 2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033847", "l": "O-phosphoserine sulfhydrylase activity", "d": ["Catalysis of the reaction: O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666008", "l": "SCAI binds SRF:MKL1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0004332", "l": "fructose-bisphosphate aldolase activity", "d": ["Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51780", "l": "4-prenylphlormethylbutanophenone + dimethylallyl diphosphate = deoxyadlupulone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873921", "l": "Binding of STAT1 to p-IFNGR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708275", "l": "PDE4A binds PDE4A inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35038", "l": "4-aminobutanoate(in) <=> 4-aminobutanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9761474", "l": "AMOT-2 binds CDH11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75174", "l": "GTP + NAD(+) <=> GDP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389532", "l": "PP2A binds CTLA4 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18334", "l": "ATP + oleandomycin => ADP + H(+) + oleandomycin 2'-O-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39899", "l": "7-deoxyloganetin + UDP-alpha-D-glucose = 7-deoxyloganin + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.324", "l": "\"7-deoxyloganetin glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39333", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+) => (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11585", "l": "L-ornithine => D-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044610", "l": "FMN transmembrane transporter activity", "d": ["Enables the directed movement of flavine mononucleotide (FMN) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985343", "l": "RUNX2 binds SOX9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61842", "l": "brassicasterol 3-beta-D-glucoside + H(+) + UDP => brassicasterol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727188", "l": "ATP4A:ATP4B binds PPIs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33765", "l": "a 2,3-saturated acyl-CoA + NADP(+) => a (2E)-enoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54435", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 <=> a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63077", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA => 2-acetylphloroglucinol + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54372", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-(2S,3R,9R)-pristinol + diphosphate", "d": []}, {"i": "EC:4.2.3.182", "l": "\"pristinol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173680", "l": "Activation of C5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392748", "l": "L1 binds to AP-2 Clathrin complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17038", "l": "indole-3-ethanol + NADP(+) => H(+) + indole-3-acetaldehyde + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052579", "l": "(+)-pulegone reductase, (+)-isomenthone as substrate, activity", "d": ["Catalysis of the reaction: (+)-isomenthone + NADP+ = (+)-pulegone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170824", "l": "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295632", "l": "PPA2A dephosphorylates SPRY2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177942", "l": "EGFR binds EGF ligand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015317", "l": "phosphate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2214351", "l": "PLK1 phosphorylates GORASP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43443", "l": "hexadecanoate + sphinganine <=> H2O + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140989", "l": "7-deoxyloganate 7-hydroxylase activity", "d": ["Catalysis of the reaction:  7-deoxyloganate + O2 + reduced [NADPH-hemoprotein reductase] = H+ + H2O +  loganate + oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21583", "l": "(2S)-2-acetolactate + H(+) <=> (R)-acetoin + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63601", "l": "H2O + neocasomorphin => L-isoleucine + neocasomorphin-(1-5)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23802", "l": "2-oxobutanoate + methanethiol + NH4(+) => H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029476", "l": "Role of myosins in phagosome formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69429", "l": "arsenite + 3 glutathione + H(+) => arsenic triglutathione + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41603", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661230", "l": "MT1A binds arsenic (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46865", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) => a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36292", "l": "3-methylxanthine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821395", "l": "PAXIP1 binds PAGR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32073", "l": "(13E)-labda-7,13-dien-15-yl diphosphate => geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46869", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) => a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38828", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947499", "l": "Exchange of oxygen with sulfur in MoCo (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050151", "l": "oleate hydratase activity", "d": ["Catalysis of the reaction: (R)-10-hydroxystearate = H2O + oleate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45231", "l": "a (3E)-enoyl-CoA <=> a 4-saturated (2E)-enoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28085", "l": "(2S)-ethylmalonyl-CoA + NADP(+) <=> (2E)-butenoyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57000", "l": "acetyl-CoA + streptothricin F = CoA + H(+) + N(beta)-acetylstreptothricin F", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34872", "l": "methanol(out) => methanol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627104", "l": "XIAP binds CASP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69074", "l": "Formation of Processive Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9660192", "l": "VDR agonists bind VDR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9687625", "l": "ATP binds MLKL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395992", "l": "p-T,4S-IRF3 is dimerized (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430308", "l": "PARVB interacts with Alpha-actinin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9016861", "l": "PTCRA gene expression is stimulated by NOTCH3 and inhibited by IK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035242", "l": "protein-arginine omega-N asymmetric methyltransferase activity", "d": ["Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951644", "l": "Release of mature NEDD8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952101", "l": "p14-ARF transcription is stimulated by RUNX proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013158", "l": "CDC42 GDIs block activation of CDC42 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40564", "l": "dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 => dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801675", "l": "PLK2 phosphorylates NPM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15665", "l": "aldehydo-D-glucose + L-lysyl-[protein] = H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41676", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + ATP = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0097363", "l": "protein O-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17968", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) <=> (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33652", "l": "(9Z,12Z)-octadecadienoate + ATP + CoA => (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23779", "l": "ATP + L-aspartate <=> 4-phospho-L-aspartate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322422", "l": "Beta-catenin recruits SMARCA4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195275", "l": "Phosphorylation of APC component of the destruction complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25969", "l": "(S)-benzoin + NADP(+) => benzil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044603", "l": "protein adenylylhydrolase activity", "d": ["Catalysis of the reaction: adenylyl-protein+ H2O = adenylate + protein; mediates the removal of an adenylyl (adenosine 5'-monophosphate; AMP group) from specific residues of target proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10032", "l": "[protein]-C-terminal-L-glutamine + H2O = [protein]-C-terminal-L-glutamate + NH4(+)", "d": []}, {"i": "EC:3.5.1.43", "l": "\"peptidyl-glutaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445069", "l": "L1-EGFR trans-heterodimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0001050", "l": "single-subunit type RNA polymerase binding", "d": ["Binding to a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54914", "l": "11-cis-retinal + H(+) + NADPH => 11-cis-retinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097077", "l": "copper ion sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50060", "l": "ATP + glycochenodeoxycholate(in) + H2O = ADP + glycochenodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56217", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50832", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450348", "l": "Activated human JNKs migrate to nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47818", "l": "9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50794", "l": "aldosterone + 2 H2O + 2 oxidized [adrenodoxin] => 18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964284", "l": "BTK in active Gq-BTK complex is activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.910167345505712", "identifiers": [{"i": "GO:0099094", "l": "ligand-gated monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of an inorganic cation by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57976", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose = (20S)-ginsenoside C-K + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34221", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58931", "l": "(3R,4R)-7,2',4'-trihydroxyisoflavanol <=> (6aR,11aR)-3,9-dihydroxypterocarpan + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004445", "l": "inositol-polyphosphate 5-phosphatase activity", "d": ["Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66087", "l": "L-kynurenine + oxaloacetate <=> H2O + kynurenate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58905", "l": "8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH => C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847880", "l": "CYTH proteins bind ARF1:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36001", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34564", "l": "CDP-alpha-D-abequose + NADP(+) => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37079", "l": "2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111264", "l": "Addition of nucleotides between position +11 and +30 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33277", "l": "a 2-acylglycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244402", "l": "botB:SYT:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62170", "l": "acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine => H2O + N,N'-diacetylchitobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933258", "l": "LSR trimer binds LDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018836", "l": "alkylmercury lyase activity", "d": ["Catalysis of the reaction: an alkylmercury + H+ = an alkane + Hg2+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854052", "l": "Formation of the SCF-FBXL7 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637764", "l": "Binding of GRB2:GAB1 complex to p-EGFRvIII mutant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168459", "l": "Lyn activates ERK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12982", "l": "H2O + O2 + S-sulfanylglutathione => glutathione + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69507", "l": "N-acetyl-D-glucosamine + O2 <=> H2O2 + N-acetyl-D-glucosamino-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60935", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.222", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9709547", "l": "ESTG binds ESR2:chaperone complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49157", "l": "dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine => dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61241", "l": "H2O + L-phenylalanine + O2 => 3-phenylpyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19135", "l": "3,5,3'-triiodothyropyruvate + L-glutamate => 2-oxoglutarate + 3,3',5-triiodo-L-thyronine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18100", "l": "pteridine-2,4,6,7-tetrol <=> H(+) + xanthine-8-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874079", "l": "PTK2 binds activated MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38462", "l": "2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA <=> 2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706350", "l": "FLT3 phosphorylates CBL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5213464", "l": "RIPK1 is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374896", "l": "Uptake of Noradrenaline (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52922", "l": "16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67586", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798748", "l": "Exocytosis of secretory granule lumen proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62147", "l": "dGMP + dGTP <=> 2 dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8981931", "l": "RAC1 and CDC42 activate PAK2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71345", "l": "chloride(in) + L-histidine(in) + 2 Na(+)(in) => chloride(out) + L-histidine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204169", "l": "PDP dephosphorylates p-lipo-PDH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9716947", "l": "ESR1 binds ESR1 agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0016669", "l": "oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a cytochrome."]}, {"i": "EC:1.8.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70371", "l": "3-oxosphinganine + decanoyl-CoA = CoA + H(+) + N-decanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000319", "l": "BORA binds PLK1 and AURKA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034867", "l": "2,4,4-trimethylpent-2-enoyl-CoA hydratase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethylpent-2-enoyl-CoA + H2O = 2,4,4-trimethyl-3-hydroxypentanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5669158", "l": "NF2 binds PAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975633", "l": "atROL binds to RBP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008257", "l": "protein histidine tele-kinase activity", "d": ["Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158399", "l": "kallikrein binds SERPING1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65828", "l": "H2O + neryl diphosphate = diphosphate + nerol", "d": []}, {"i": "EC:3.1.7.13", "l": "\"neryl diphosphate diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-912727", "l": "CBL binds VAV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212658", "l": "Tranport of L-Glutamate (mitochondrial matrix) to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070840", "l": "dynein complex binding", "d": ["Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28880", "l": "H(+)(in) + L-tryptophan(in) => H(+)(out) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65579", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate <=> an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983707", "l": "SYK autophosphorylates at the activated BCR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39432", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28986", "l": "nitrite(in) <=> nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019010", "l": "farnesoic acid O-methyltransferase activity", "d": ["Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73991", "l": "geranylgeranyl diphosphate = beta-araneosene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71653", "l": "an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H(+) + nicotinamide => a thymidine in DNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49006", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+) => aurachin C + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22323", "l": "2 alpha-D-glucose 1-phosphate + H2O <=> D-maltose + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396029", "l": "Latent TGF-beta-3 binds integrins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34795", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O = alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}, {"i": "EC:3.1.4.55", "l": "\"phosphoribosyl 1,2-cyclic phosphate phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66745", "l": "ATP + H2O + N-acetyl-L-aspartate(in) => ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669250", "l": "PAK1 phosphorylates FLNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009817", "l": "Acitretin binds to RAR:RXR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50453", "l": "prostaglandin H3 => prostaglandin E3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770847", "l": "Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38615", "l": "cyclic ADP-beta-D-ribose + H2O = ADP-D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420128", "l": "SRC-1 phosphorylates SHB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22842", "l": "D-glutamate + NH4(+) => D-glutamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38859", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose = bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55387", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate <=> 6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70276", "l": "H2O + raffinose => D-galactose + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811412", "l": "Active ARF recruits coatomer to the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944214", "l": "Association of procollagen type I (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22705", "l": "2 H2O + ricinine => 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417843", "l": "P2Y13 binds ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677051", "l": "Formation of the PCAF-ATAC complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759137", "l": "NFE2L2 and MAFK bind the HMOX1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22081", "l": "H(+) + NADH + O2 + quinolin-2-ol => H2O + NAD(+) + quinoline-2,8-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69987", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + NADP(+) = (22S)-22-hydroxycampest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9627369", "l": "SEPT4 binds XIAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373732", "l": "Nephrin trans-homophilic interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41762", "l": "CMP + ganglioside GD3 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990450", "l": "linear polyubiquitin binding", "d": ["Binding to a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66452", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+) = 1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48028", "l": "H2O + triacetin = acetate + diacetylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164524", "l": "Fusion of viral membrane with host cell membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27357", "l": "iodide + S-adenosyl-L-methionine = iodomethane + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18274", "l": "H2O + O2 + putrescine => 4-aminobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56061", "l": "H(+) + hexadecanoate + hnu => CO2 + pentadecane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19348", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate <=> (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062188", "l": "anandamide 11,12 epoxidase activity", "d": ["Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]."]}, {"i": "RHEA:53144", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73767", "l": "cyclo(L-tryptophyl-L-alanyl) + dimethylallyl diphosphate = diphosphate + preechinulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018754", "l": "GDIs bind RHOH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18809", "l": "L-alanine + oxomalonate = aminomalonate + pyruvate", "d": []}, {"i": "EC:2.6.1.47", "l": "\"alanine--oxomalonate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112434", "l": "Formation of DSIF complex  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39114", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) <=> 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102261", "l": "8-hydroxy-5-deazaflavin:NADPH oxidoreductase activity", "d": ["Catalysis of the reaction: NADP + a reduced coenzyme F420 <=> NADPH + H+ + an oxidized coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156832", "l": "INF-gamma induced phosphorylation of L13a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70210", "l": "sphinga-4E,14Z-dienine-1-phosphate(in) <=> sphinga-4E,14Z-dienine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60891", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O <=> (N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35157", "l": "(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one => (S)-4,5-dihydroxypentane-2,3-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698265", "l": "Enhanced autophagosome formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3642203", "l": "Dimeric TGFB1 does not bind TGFBR2 MSI frameshift mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53965", "l": "4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin => gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8862300", "l": "LYZ binds bacterial peptidoglycan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75706", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate <=> 14,15-epoxy-12-hydroxy-(10E)-eicosenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611851", "l": "ADRB2 bind ADR,NAd (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134800", "l": "STING dimerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169719", "l": "Secreted CD14 binds LPS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59276", "l": "L-glutamine = D-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201457", "l": "BMP2 binds to the receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51622", "l": "CO2 + dCTP + H2O => CTP + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9718379", "l": "GNRHR binds chemical antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033405", "l": "UCU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UCU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.9.-", "l": "\"With a copper protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27316", "l": "2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+) => dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20889", "l": "3-hydroxy-2-methylpropanoyl-CoA + H2O => 3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031804", "l": "type 7 metabotropic glutamate receptor binding", "d": ["Binding to a type 7 metabotropic glutamate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63232", "l": "(2E)-octenoyl-CoA + H(+) + NADH = NAD(+) + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050117", "l": "N-acetyl-beta-alanine deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-beta-alanine + H2O = beta-alanine + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30614", "l": "A + all-trans-zeta-carotene <=> AH2 + all-trans-neurosporene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53243", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682011", "l": "LC3 binds ATG7 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938158", "l": "PRKCQ gene expression is stimulated by RUNX1:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72378", "l": "hydrogencarbonate(out) + iodide(in) <=> hydrogencarbonate(in) + iodide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50799", "l": "glutathione + prostaglandin A2 <=> prostaglandin A2-S-(R)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2534365", "l": "Slo3 Potassium Transport (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64813", "l": "acetyl-CoA + S-(2-aminoethyl)-homocysteine => CoA + H(+) + S-(2-acetamidoethyl)-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56416", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate = alpha-D-glucose 1-phosphate + glycerol", "d": []}, {"i": "EC:2.4.1.359", "l": "\"glucosylglycerol phosphorylase (configuration-retaining)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20523", "l": "acetoacetate + H(+) + NADH => (R)-3-hydroxybutanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015232", "l": "heme transmembrane transporter activity", "d": ["Enables the transfer of heme from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187575", "l": "Ubiquitination of phospho-p27/p21 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49254", "l": "D-fructose 1-phosphate(in) + L-histidyl-[protein] => D-fructose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73719", "l": "3,4-dihydroxybenzoate + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9815510", "l": "MIB2 binds CYLD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66660", "l": "ATP + beta-D-glucosylceramide(in) + H2O = ADP + beta-D-glucosylceramide(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72528", "l": "1-hydroxy-6-methoxyphenazine + S-adenosyl-L-methionine => 1,6-dimethoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8960973", "l": "RLBP1:11cRAL dissociates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68874", "l": "(E)-cinnamaldehyde + AMP + diphosphate + NADP(+) => (E)-cinnamate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28978", "l": "H(+)(out) + L-asparagine(in) <=> H(+)(in) + L-asparagine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29347", "l": "2 H(+)(in) + orotate(in) = 2 H(+)(out) + orotate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44091", "l": "ATP + CoA + heptanoate <=> AMP + diphosphate + heptanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49054", "l": "asperlicin E + H2O + NAD(+) => asperlicin C + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75871", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}, {"i": "EC:2.1.1.385", "l": "\"[methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]--tetrahydrofolate methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373713", "l": "DCC heterodimerizes with UNC-5:Netrin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654625", "l": "Activated FGFR3 binds SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604831", "l": "NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38896", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31825", "l": "cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31149", "l": "3,4-dihydroxymandelaldehyde + H(+) + NADH => 3,4-dihydroxyphenylethyleneglycol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21871", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56369", "l": "3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 => 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16051", "l": "adenosylcob(III)alamin + GMP + H(+) => adenosylcob(III)inamide-GDP + alpha-ribazole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14401", "l": "chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.225", "l": "\"chlordecone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944254", "l": "Association of procollagen type XXVI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48742", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024785", "l": "RvD1-6 translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42491", "l": "(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III <=> 3'-N-debenzoyl-2'-deoxytaxol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851436", "l": "CFHR dimers bind C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20048", "l": "3-oxopropanoate + H2O + NAD(+) <=> 2 H(+) + malonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73706", "l": "UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-glucosamine(in) <=> UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-glucosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49349", "l": "2,2-dihydroxyspirilloxanthin => 2-oxospirilloxanthin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112379", "l": "Recruitment of elongation factors to form elongation complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74338", "l": "O-2-methylbutanoyl-(R)-carnitine(in) <=> O-2-methylbutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429529", "l": "Thrombin binding to GP1b:IX:V (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647746", "l": "EML4 trimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070523", "l": "11-beta-hydroxysteroid dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54203", "l": "N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218805", "l": "PKC autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48596", "l": "1,2-didecanoylglycerol + H2O = decanoate + decanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757954", "l": "N4BP1 binds IKBKG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4167511", "l": "HLCS biotinylates ACACB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5362522", "l": "ALDHs oxidise atRAL to atRA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25886", "l": "H(+) + N(2)-succinyl-L-citrulline + phosphate => carbamoyl phosphate + N(2)-succinyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54310", "l": "H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28952", "l": "H(+)(in) + L-arabinose(in) => H(+)(out) + L-arabinose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53818", "l": "L-cysteine + succinate => hydrogen sulfide + O-succinyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43357", "l": "cholesteryl (9Z,12Z)-octadecadienoate(in) => cholesteryl (9Z,12Z)-octadecadienoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17805", "l": "H2O + S-adenosyl-L-homocysteine = adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16346", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65750", "l": "CO2 + dodecanal + H(+) + succinate + sulfate => 2-oxoglutarate + dodecyl sulfate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610752", "l": "GLI3R translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33935", "l": "2 N(omega)-hydroxy-L-arginine + NADH + 2 O2 = H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46722", "l": "(2E)-hexenoyl-CoA + H2O => (3R)-hydroxyhexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65866", "l": "5alpha-androstan-1,3,17-trione + AH2 => 5alpha-androst-1-ene-3,17-dione + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036311", "l": "chitin disaccharide deacetylase activity", "d": ["Catalysis of the reaction: 2-(acetylamino)-4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-2-deoxy-beta-D-glucopyranose + H2O = 2-(acetylamino)-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta-D-glucopyranose + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.48", "l": "\"15-oxoprostaglandin 13-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23511", "l": "(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O <=> (7R)-7-aminocephalosporanate + glutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730899", "l": "Oligomerization of BCL10 and MALT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15462", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74037", "l": "D-serine(in) + L-alanine(out) => D-serine(out) + L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48469", "l": "ganglioside GM1b (d18:1(4E)) + H2O => ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804741", "l": "MDM2 forms homo- or heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.50", "l": "\"alpha-N-acetylglucosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29826", "l": "chloride(in) <=> chloride(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16811", "l": "pyruvate + succinate => (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.25", "l": "\"glycyl endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.-.-", "l": "\"Carbon-carbon lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70991", "l": "H(+)(in) + L-mannopyranose(in) = H(+)(out) + L-mannopyranose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54399", "l": "1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16561", "l": "H2O + squalene = hopan-22-ol", "d": []}, {"i": "EC:4.2.1.129", "l": "\"squalene--hopanol cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60737", "l": "(2E,6E)-farnesal + H2O + NADP(+) => (2E,6E)-farnesoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6805061", "l": "CK2 binds FACT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19670", "l": "GTP + H2O => GDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75743", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH = 10-hydroxy-(11E)-octadecenoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65239", "l": "3-methylbutanol + acetyl-CoA <=> 3-methylbutyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51951", "l": "(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19042", "l": "(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] => (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39919", "l": "1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O = 1-O-(alk-1-enyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625426", "l": "Retrograde IFT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2467794", "l": "Resolution of sister chromatids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56879", "l": "(R)-N-acetyl-1-phenylethylamine + H2O <=> (R)-1-phenylethylamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52833", "l": "1-hydroxylimonen-2-one + H(+) + NADPH + O2 => 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419861", "l": "Melanospin is stimulated by light (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16767", "l": "D-fructose + H(+) + NADPH => D-mannitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018576", "l": "catechol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: catechol + O2 = cis,cis-muconate."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0031626", "l": "beta-endorphin binding", "d": ["Binding to beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450387", "l": "HuR binds the CRM1 nuclear export machinery (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44010", "l": "a 2-methyl fatty acid + 2 H(+) + NADH => a 2-methyl-branched fatty aldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1964496", "l": "STING binds TRIM32 or TRIM56  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54635", "l": "2-oxoglutarate + O2 + tetradecanoyl-CoA <=> 2-hydroxytetradecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19849", "l": "H2O + NADP(+) = ADP-D-ribose 2'-phosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54220", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene = all-trans-neurosporene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42796", "l": "(9Z,12Z)-octadecadienoyl-CoA + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.25", "l": "\"lipopolysaccharide heptosyltransferase III\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17460", "l": "[sulfur-carrier protein]-L-cysteine + L-cysteine <=> [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14033", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol = 1D-myo-inositol 1-phosphate + glycerol + H(+)", "d": []}, {"i": "EC:3.1.4.43", "l": "\"glycerophosphoinositol inositolphosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22615", "l": "(3S)-citramalyl-CoA <=> acetyl-CoA + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74447", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21745", "l": "S-adenosyl-L-methionine => 1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51145", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 => (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69542", "l": "6-O-guanylylstreptomycin + diphosphate => GTP + streptomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997237", "l": "SH2B proteins bind JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52489", "l": "O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26417", "l": "a secondary aliphatic amine + H2O + O2 <=> a primary amine + an aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64195", "l": "H2O + N-(9Z-octadecenoyl)-L-lysine <=> (9Z)-octadecenoate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59346", "l": "D-maltobiono-1,5-lactone + H2O2 => D-maltose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322434", "l": "XIAP dissociates from ub-TLE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49030", "l": "(-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32661", "l": "(6E)-8-oxogeranial + 2 H(+) + 2 NADPH => (6E)-8-hydroxygeraniol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693148", "l": "BCKDK phosphorylates BCKDH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954208", "l": "ERBB4s80:ESR1 binds PGR gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209738", "l": "VD3 binds GC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357445", "l": "PAK1-3 dimer disassociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050003", "l": "deoxycytidylate C-methyltransferase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP = 2'-deoxy-5-methyl-5'-cytidylate + 7,8-dihydrofolate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070577", "l": "lysine-acetylated histone binding", "d": ["Binding to a histone in which a lysine residue has been modified by acetylation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865107", "l": "MICAL1 produces NADP+, H2O2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9634850", "l": "NPAS4 binds ARNT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44269", "l": "3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA => 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21664", "l": "4-nitrophenyl phosphate + H2O = 4-nitrophenol + H(+) + phosphate", "d": []}, {"i": "EC:3.1.3.41", "l": "\"4-nitrophenylphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114354", "l": "SMAC binds XIAP:Caspase-7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382056", "l": "Crk binds to the active PDGF receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53834", "l": "a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate => 2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39343", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA = (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18082", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + pentalenene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944233", "l": "Association of procollagen type XIX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014296", "l": "RAC2 GEFs activate RAC2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58857", "l": "(6E)-8-hydroxygeraniol + NAD(+) => (6E)-8-oxogeraniol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65997", "l": "Co(I)-[glycine betaine-specific corrinoid protein] + glycine betaine + H(+) => methyl-Co(III)-[glycine betaine-specific corrinoid protein] + N,N-dimethylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801109", "l": "CHM binds RGGT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39710", "l": "a long-chain fatty acyl-CoA(out) <=> a long-chain fatty acyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863494", "l": "ASICs bind STOML3, (STOM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2328037", "l": "Fibrillin-1 binds integrins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9006873", "l": "IL21 receptor STAT binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35456", "l": "5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2 => (25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015351", "l": "bilirubin secondary active transmembrane transporter activity", "d": ["Enables the transfer of bilirubin from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029468", "l": "Conversion of PA into DAG by PAP-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47209", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022911", "l": "CSPG is secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730902", "l": "Oligomerization of p-CARMA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674018", "l": "BRAP binds RAS:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034539", "l": "3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity", "d": ["Catalysis of the reaction: 3,3',5,5'-tetrabromobisphenol A + 2 H+ + 2 e- = 3,3',5-tribromobisphenol A + HBr."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5138432", "l": "DVL2 is phosphorylated by PKC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429955", "l": "CCR4-NOT complex deadenylates mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.77", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64906", "l": "GMP + 2 H(+) + 2 phosphate => GTP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35262", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O <=> 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55095", "l": "D-fructose + UDP-alpha-D-glucose <=> H(+) + sucrose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950456", "l": "IL12B dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626817", "l": "PKC phosphorylates NCF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10432", "l": "2-(acetamidomethylene)succinate + H(+) + 2 H2O = acetate + CO2 + NH4(+) + succinate semialdehyde", "d": []}, {"i": "EC:3.5.1.29", "l": "\"2-(acetamidomethylene)succinate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49081", "l": "dibenzothiophene 5-oxide + FMNH2 + O2 => dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762343", "l": "PREDL:ALB dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031774", "l": "leukotriene receptor binding", "d": ["Binding to a leukotriene receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19206", "l": "dCTP + 2 H2O => diphosphate + dUMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54092", "l": "3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 = 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411357", "l": "TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0015026", "l": "coreceptor activity", "d": ["Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59456", "l": "NADP(+) + tetradecan-1-ol = H(+) + NADPH + tetradecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018867", "l": "5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814831", "l": "TBC1D20 binds RAB1:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446391", "l": "Formation of the PINCH-ILK-parvin complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19974", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + S-methyl-5'-thioadenosine + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27803", "l": "(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate => all-trans-decaprenyl diphosphate + 7 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69598", "l": "adenosine + IMP => AMP + inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20814", "l": "acetyl-CoA + oxaloacetate => (3S)-citryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0043916", "l": "DNA-7-methylguanine glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0004485", "l": "methylcrotonoyl-CoA carboxylase activity", "d": ["Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615910", "l": "SUMOylation of PCNA with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50795", "l": "18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> aldosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047905", "l": "fructose-6-phosphate phosphoketolase activity", "d": ["Catalysis of the reaction: D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71498", "l": "6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) <=> 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692764", "l": "MAPK6 binds CCND3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70642", "l": "H2O + N(6)-hexanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-hexanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44907", "l": "alpha-D-glucose 6-phosphate + H2O <=> alpha-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22509", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) => diphosphate + DNA(n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14691", "l": "3,4-dihydroxyphenylacetate + chloride + NAD(+) => 4-chlorophenylacetate + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062066", "l": "PSII associated light-harvesting complex II binding", "d": ["Binding to a PSII associated light-harvesting complex II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26389", "l": "all-trans-beta-carotene + O2 = all-trans-10'-apo-beta-carotenal + beta-ionone", "d": []}, {"i": "EC:1.13.11.71", "l": "\"carotenoid-9',10'-cleaving dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990648", "l": "inositol-4,5,6-triphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 4,5,6-trisphosphate + H2O = 1D-myo-inositol 4,6-bisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102402", "l": "2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity", "d": ["Catalysis of the reaction: 2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside + H2O = 2-phenylethanol + 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65668", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018486", "l": "2-butanone oxidase activity", "d": ["Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52993", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine => [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63339", "l": "alpha-D-xylose <=> beta-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264865", "l": "Caspase-mediated cleavage of Lamin A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159733", "l": "Furin cleaves pro-factor X to factor X (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48863", "l": "18-HEPE + O2 <=> (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60702", "l": "a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline => a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55519", "l": "11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69581", "l": "dGMP + inosine => 2'-deoxyguanosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64285", "l": "2-phenylethylamine + pyruvate => 2-phenylacetaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390673", "l": "CHRM2,4 bind acetylcholine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009541", "l": "ESR1 binds to TFF1 gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27971", "l": "D-maltotriose + H2O => alpha-D-glucose + D-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48738", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72126", "l": "Na(+)(out) + O-butanoyl-(R)-carnitine(out) <=> Na(+)(in) + O-butanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57597", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "28.358858483664388", "identifiers": [{"i": "GO:0003674", "l": "molecular_function", "d": ["A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.", "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52609", "l": "2-hydroxybutanoate + NADP(+) => 2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606327", "l": "Phosphorylation and release of IRF3  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69272", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate = allyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75816", "l": "ATP + H2O + K(+)(in) => ADP + H(+) + K(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102713", "l": "gibberellin A25 hydroxylase activity", "d": ["Catalysis of the reaction: gibberellin A25 + 2-oxoglutarate(2-) + O2 <=> gibberellin A46 + succinate(2-) + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15938", "l": "a primary alcohol + NADP(+) => an aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34969", "l": "sn-glycerol 3-phosphate(out) => sn-glycerol 3-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48645", "l": "prostaglandin H2 => (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714483", "l": "RAC2 translocates to the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018794", "l": "RHOV binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40994", "l": "(E)-4-coumaroyl-CoA + H2O <=> 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41883", "l": "(2E)-dodecenoyl-[ACP] + H(+) + NADPH <=> dodecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63501", "l": "H(+) + NADPH + S-nitrosoglutathione => NADP(+) + sulfinamide glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24641", "l": "ergosteryl 3-beta-D-glucoside + H2O => D-glucose + ergosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730904", "l": "Auto-ubiquitination of TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102682", "l": "N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity", "d": ["Catalysis of the reaction: N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O <=> N(6)-dimethylallyladenine + D-ribofuranose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-418553", "l": "cAMP degradation by Phosphodiesterases (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672973", "l": "MAP2Ks phosphorylate MAPKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30637", "l": "a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51959", "l": "(E)-2-methylpropanal oxime <=> (Z)-2-methylpropanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23879", "l": "protoaphin aglucone <=> H2O + xanthoaphin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56081", "l": "[Rab1 protein]-L-serine + CDP-choline => [Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41252", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187828", "l": "Translocation of p21 to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944227", "l": "Association of procollagen type XXII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62777", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948066", "l": "K63polyUb-IRAK1 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443783", "l": "Interaction of NUMB with L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20281", "l": "(Z)-desulfoglucotropeolin + 3'-phosphoadenylyl sulfate = (Z)-glucotropeolin + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11021", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941411", "l": "OSCN- reacts with Cys residues (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322427", "l": "Beta-catenin recruits CBP/p300 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73865", "l": "dopamine(in) => dopamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19883", "l": "diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein] => GTP + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36273", "l": "formaldehyde + H2O + NADP(+) + theobromine => caffeine + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004001", "l": "adenosine kinase activity", "d": ["Catalysis of the reaction: ATP + adenosine = ADP + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25441", "l": "(2E,6E)-farnesyl diphosphate => delta-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928578", "l": "EPH receptors autophosphorylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66529", "l": "ATP + O-(5'-adenylyl)-L-tyrosyl-[protein] => diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047867", "l": "dimethylmalate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-3,3-dimethylmalate + NAD+ = 3-methyl-2-oxobutanoate + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1011598", "l": "DOCKs bind to RhoGEFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37530", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.47", "l": "\"acyl-lipid (9-3)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51598", "l": "4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641205", "l": "RSPO:LGR binds ZNRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17028", "l": "NADP(+) + xylitol <=> H(+) + L-xylulose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.162", "l": "\"lambda-carrageenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37207", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59180", "l": "5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O = 2 AMP + H(+)", "d": []}, {"i": "EC:3.1.4.60", "l": "\"pApA phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73651", "l": "CTP(out) = CTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428918", "l": "Dissociation of the TP:G13 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853792", "l": "RET tyrosine phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49590", "l": "D-erythrulose 4-phosphate => L-erythrulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42639", "l": "AH2 + L-cysteine + Mo-molybdopterin <=> A + H2O + L-alanine + thio-Mo-molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627350", "l": "SMAC (DIABLO) binds XIAP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15828", "l": "AZD1979 + H2O <=> AZD1979 oxetane hydrolysis product + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2660819", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858428", "l": "FCAMR binds IgA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705010", "l": "SARS-CoV-2 nsp6 binds TBK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211164", "l": "AKT phosphorylates FOXO1A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36339", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19411", "l": "3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH => cholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15267", "l": "H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate => 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15355", "l": "all-trans-antheraxanthin + H2O + L-dehydroascorbate => all-trans-violaxanthin + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34752", "l": "ATP + N-acyl-15-methylhexadecasphing-4-enine => ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17384", "l": "(9Z,12Z)-octadecadienoate <=> (9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68380", "l": "3-hydroxypyruvate + L-asparagine = 2-oxosuccinamate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665726", "l": "ERBB2 binds pertuzumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72156", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) => 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30150", "l": "FADH2 + NAD(+) <=> FAD + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047755", "l": "isocitrate epimerase activity", "d": ["Catalysis of the reaction: D-threo-isocitrate = D-erythro-isocitrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9828175", "l": "Formation of the NSL complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16484", "l": "3 S-adenosyl-L-methionine <=> 3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004800", "l": "thyroxine 5'-deiodinase activity", "d": ["Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75440", "l": "eburicol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 14-demethyleburicol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9006873", "l": "IL21 receptor STAT binding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44559", "l": "4-hydroxybenzoate + all-trans-hexaprenyl diphosphate <=> 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.68", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59760", "l": "apigenin + UDP-alpha-D-glucose = apigenin 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985644", "l": "COL1A1 gene expression is stimulated by RUNX2 and RB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047005", "l": "16-alpha-hydroxysteroid dehydrogenase activity", "d": ["Catalysis of the reaction: NADP+ + 16-alpha-hydroxysteroid = NADPH + H+ + 16-oxosteroid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71930", "l": "2 Na(+)(out) + tauroursodeoxycholate(out) <=> 2 Na(+)(in) + tauroursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602606", "l": "Defective MyD88 does not bind MAL(TIRAP):TLR2/4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952419", "l": "SMURFs ubiquitinate RUNX3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879910", "l": "JAK2 is phosphorylated, activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199404", "l": "CD40L binds CD40 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46896", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) = a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052627", "l": "vanillate amino acid synthetase activity", "d": ["Catalysis of the reaction: vanillate + ATP + amino acid = vanillate amino acid conjugate + AMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106261", "l": "tRNA uridine(34) acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H+ + L-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13967", "l": "L-homocysteine + NH4(+) + pyruvate => H2O + L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59515", "l": "acetylsalicylate + L-seryl-[protein] <=> O-acetyl-L-seryl-[protein] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48528", "l": "ganglioside GP1c (d18:1(4E)) + H2O = ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61303", "l": "5-deoxy-D-ribulose 1-phosphate <=> acetaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42628", "l": "S-adenosyl-L-methionine + uridine(747) in 23S rRNA = 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.189", "l": "\"23S rRNA (uracil(747)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20639", "l": "D-glucono-1,5-lactone + D-sorbitol => D-fructose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32641", "l": "(6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29070", "l": "formate + H(+) + menaquinone-8 <=> CO2 + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50606", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein] => acetyl-CoA + N-terminal L-methionyl-[transmembrane protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36539", "l": "hexadecanoyl-CoA + sphinganine = CoA + H(+) + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47902", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate => ganglioside GM3 (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39054", "l": "ATP + cholesterol(in) + H2O <=> ADP + cholesterol(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44584", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.163", "l": "\"demethylmenaquinone methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26057", "l": "diphosphate + GDP-valienol => GTP + H(+) + valienol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44766", "l": "6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25643", "l": "(R)-pulegone + H(+) + NADPH => (1R,4S)-menthone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12213", "l": "9H-fluoren-9-ol + NADP(+) => 9H-fluoren-9-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432129", "l": "FGR binds and phosphorylates LRP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61253", "l": "H2O + L-valine + O2 => 3-methyl-2-oxobutanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682769", "l": "LGI2 binds ADAM22,23 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41366", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4331331", "l": "TP53 binds the PMAIP1 (NOXA) promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102995", "l": "angelicin synthase activity", "d": ["Catalysis of the reaction: columbianetin + NADPH + O2 + H+ <=> angelicin + acetone + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031777", "l": "type 1 melanin-concentrating hormone receptor binding", "d": ["Binding to a type 1 melanin-concentrating hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14165", "l": "acetyl-CoA + L-aspartate = CoA + H(+) + N-acetyl-L-aspartate", "d": []}, {"i": "EC:2.3.1.17", "l": "\"aspartate N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42894", "l": "5'-deoxyinosine + NH4(+) => 5'-deoxyadenosine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399946", "l": "Recruitment and activation of Cdk5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433542", "l": "Phosphorylation and activation of VAV1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451895", "l": "IL2RG binds JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067667", "l": "IL6 binds IL6R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44225", "l": "16-hydroxyhexadecanoate + ATP + CoA => 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017817", "l": "Gamma-secretase cleaves YBX1:NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15553", "l": "1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate", "d": []}, {"i": "EC:3.1.3.57", "l": "\"inositol-1,4-bisphosphate 1-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48888", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34120", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA => 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33683", "l": "H(+) + L-serine + octadecanoyl-CoA = 3-oxoeicosasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73804", "l": "dimethylallyl diphosphate + neoechinulin B => diphosphate + isoechinulin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62991", "l": "dodecanamide + H2O <=> dodecanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58734", "l": "5-methyl-CMP + diphosphate + H(+) => 5-methyl-CTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68307", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] <=> 3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071566", "l": "UFM1 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3828061", "l": "Defective GYS1 does not transfer glucose to growing glycogen chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59233", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => diphosphate + hydropyrenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47831", "l": "ganglioside GT1b + H2O <=> ganglioside GD1b + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43759", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45604", "l": "D-glucaro-1,4-lactone = 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50018", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine => H2O + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26381", "l": "4-hydroxybutanoate + NADP(+) = H(+) + NADPH + succinate semialdehyde", "d": []}, {"i": "EC:1.1.1.n11", "l": "\"succinic semialdehyde reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6805061", "l": "CK2 binds FACT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.850581069382244", "identifiers": [{"i": "GO:0140104", "l": "molecular carrier activity", "d": ["Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102039", "l": "NADH-dependent peroxiredoxin activity", "d": ["Catalysis of the reaction: a hydroperoxide + H+ + NADH = an alcohol + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202717", "l": "Heterodimerization of CEACAMs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54712", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10551", "l": "L-arginine + O2 <=> 4-guanidinobutanamide + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35414", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside <=> an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside] + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070007", "l": "glutamic-type endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009072", "l": "STAT3 phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373074", "l": "Receptor CCR9  binds CCL25 ligand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390673", "l": "CHRM2,4 bind acetylcholine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026917", "l": "Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36682", "l": "dTDP-6-deoxy-alpha-D-allose + NAD(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47545", "l": "trans-4-hydroxy-L-proline betaine => cis-4-hydroxy-D-proline betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.22", "l": "\"succinyl-CoA--L-malate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9010815", "l": "SLITs bind keratan sulfate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46694", "l": "4-hydroxybenzoyl-5'-AMP + diphosphate => 4-hydroxybenzoate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114284", "l": "Release of Cytochrome c from mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103040", "l": "aldose sugar dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + an aldose + an oxidized electron acceptor = H+ + an aldonate + a reduced electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818937", "l": "MEN1 binds MLL1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57799", "l": "4-nitrotoluene + NADH + O2 <=> 4-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59471", "l": "an S-substituted glutathione + H2O <=> an S-substituted L-cysteinylglycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38643", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211951", "l": "CYP1B1 4-hydroxylates EST17b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22755", "l": "A + H2O + uracil <=> AH2 + barbiturate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49868", "l": "(+)-dehydrodiconiferyl acid + a quinone = (+)-dehydrodiconiferyl acid ketone + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74804", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41290", "l": "H2O + N-tetradecanoylsphing-4-enine <=> sphing-4-enine + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625378", "l": "STK11 gene transcription is stimulated by FOXO3,FOXO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10365", "l": "2-oxoglutarate + dodecanoyl-CoA + H2O => (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062182", "l": "all-trans retinoic acid 4-hydrolase activity", "d": ["Catalysis of the reaction: all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S)-hydroxyretinoate + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."]}, {"i": "RHEA:51492", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30004", "l": "alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose => alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48511", "l": "cholate + NADP(+) <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67556", "l": "3'-phosphoadenylyl sulfate + glycocholate = adenosine 3',5'-bisphosphate + glycocholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18319", "l": "a D-alpha-amino acid => an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62185", "l": "peregrinol diphosphate => diphosphate + labd-13(16),14-diene-9-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65926", "l": "2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine => 2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.175", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57128", "l": "H2O + 2 oxidized [azurin] + tyramine = (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45648", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44747", "l": "4 H(+) + 4 malonyl-CoA <=> (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52975", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74090", "l": "an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP <=> ADP + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853405", "l": "TPX2 binds AURKA at centrosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59362", "l": "beta-alanine + L-histidine => carnosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37454", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021068", "l": "PalmS-ESRs bind CAVs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730835", "l": "Autophosphorylation of PKC-theta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098882", "l": "structural constituent of presynaptic active zone", "d": ["The action of a molecule that contributes to the structural integrity of a presynaptic active zone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68415", "l": "H2O + L-glutamate 5-semialdehyde + NADP(+) <=> 2 H(+) + L-glutamate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26520", "l": "acryloyl-CoA + H2O => 3-hydroxypropanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0045513", "l": "interleukin-27 binding", "d": ["Binding to interleukin-27."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73950", "l": "(2E)-geranyl diphosphate <=> (4E,6E)-allo-ocimene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166220", "l": "FA anion diffuses laterally to UCP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17088", "l": "4-pyridoxate + A <=> 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38753", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67883", "l": "3'-phosphoadenylyl sulfate + dopamine <=> adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797090", "l": "CCNK binds CDK12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340226", "l": "CYGB dioxygenates NO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60008", "l": "a tRNA precursor + 2 CTP = a tRNA with a 3' CC end + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49045", "l": "H(+) + NADH + O2 + protoasukamycin => 4-hydroxyprotoasukamycin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70400", "l": "3-oxosphinganine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27298", "l": "2-formylbenzoate + H2O + NAD(+) = 2 H(+) + NADH + phthalate", "d": []}, {"i": "EC:1.2.1.78", "l": "\"2-formylbenzoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73496", "l": "an 8-hydroxyflavone + S-adenosyl-L-methionine => an 8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004023", "l": "alcohol dehydrogenase activity, metal ion-independent", "d": ["Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49011", "l": "aurachin C + H(+) + NADPH + O2 <=> aurachin C epoxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989776", "l": "Expression of APOA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17690", "l": "3'-phosphoadenylyl sulfate + glycochenodeoxycholate => adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22163", "l": "4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside <=> a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63398", "l": "AH2 + Fe(II)-hydroxyheme i => A + Fe(II)-heme i + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49113", "l": "phenazine-1-carboxylate + S-adenosyl-L-methionine => 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6804527", "l": "INTL1 binds bacterial glycans (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013023", "l": "RHOB GEFs activate RHOB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18579", "l": "3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine => 3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75316", "l": "chloride(out) + D-serine(out) + 2 Na(+)(out) => chloride(in) + D-serine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75850", "l": "Addition of the third nucleotide on the nascent transcript (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56981", "l": "4-hydroxybenzyl alcohol + 2 oxidized [azurin] => 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036189", "l": "abieta-7,13-diene hydroxylase activity", "d": ["Catalysis of the reaction: abieta-7,13-diene + NADPH + H+ + O2 = abieta-7,13-dien-18-ol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33152", "l": "(R)-dihydrolipoamide + acetyl-CoA => (R)-S(6)-acetyldihydrolipoamide + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34971", "l": "Fe(3+)(in) = Fe(3+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71103", "l": "L-methionine(in) + S-methylmercury-L-cysteine(out) = L-methionine(out) + S-methylmercury-L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22670", "l": "H(+) + lipid A disaccharide (E. coli) + UDP => 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70510", "l": "LDH tetramer oxidises LACT to PYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60505", "l": "1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44831", "l": "(R)-carnitine + decanoyl-CoA <=> CoA + O-decanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.-", "l": "\"Pentosyltransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72425", "l": "(E)-4-coumaroyl-CoA + AMP + H(+) => (E)-4-coumaroyl-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807242", "l": "25(OH)D translocates from ER membrane to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683836", "l": "SFTPC gene produces pro-SFTPC protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709317", "l": "CO binds to free ferrohemoglobin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60825", "l": "H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate => 2 AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678327", "l": "MIOX oxidises Ins to GlcA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48459", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O <=> 2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49151", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31375", "l": "H(+) + pyrrole-2-carboxylate = 1H-pyrrole + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15477", "l": "3'-phosphoadenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}, {"i": "EC:2.8.2.32", "l": "\"scymnol sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73818", "l": "O2 + piceatannol <=> 3,4-dihydroxybenzaldehyde + 3,5-dihydroxybenzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25963", "l": "benzoin + NADP(+) <=> benzil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68726", "l": "26-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 26-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74603", "l": "CMP(out) + UDP-alpha-D-galactose(in) = CMP(in) + UDP-alpha-D-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050365", "l": "tryptophanamidase activity", "d": ["Catalysis of the reaction: L-tryptophanamide + H2O = L-tryptophan + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784735", "l": "PCSK9:LDLR bind to Clathrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37264", "l": "ATP + H2O + L-alanyl-L-aspartate(out) => ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55809", "l": "a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3266557", "l": "Factor I cleaves iC3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641134", "l": "SMURF2 binds AXIN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70139", "l": "6-deoxo-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-28-nortyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23925", "l": "pppGp(2'-5')A => 2',3'-cGAMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24244", "l": "NADP(+) + pseudotropine = H(+) + NADPH + tropinone", "d": []}, {"i": "EC:1.1.1.236", "l": "\"tropinone reductase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651789", "l": "LIG1 bound to POLB ligates SSB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28061", "l": "L-lyxopyranose <=> L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56246", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein] => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14685", "l": "A + a primary alcohol = AH2 + an aldehyde", "d": []}, {"i": "EC:1.1.99.20", "l": "\"alkan-1-ol dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653745", "l": "Translation of ATF5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437230", "l": "L1-FGFR cis-heterodimerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41806", "l": "(3R)-hydroxybutanoyl-[ACP] + NADP(+) => 3-oxobutanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61667", "l": "(2E,6E,10E)-geranylgeraniol + ATP <=> (2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-706479", "l": "TAK1 is activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36150", "l": "acetyl-CoA + benzyl alcohol <=> benzyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37700", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40912", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043136", "l": "glycerol-3-phosphatase activity", "d": ["Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57625", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42069", "l": "(3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH => clavulanate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788707", "l": "TRMT44 2'-O-methylates uridine-44 in tRNA(Ser) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25607", "l": "2-(3-methylsulfanyl)propylmalate + CoA + H(+) => 2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112430", "l": "Formation of P-TEFb complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.098124162625822", "identifiers": [{"i": "GO:0030674", "l": "protein-macromolecule adaptor activity", "d": ["The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46452", "l": "2 L-leucyl-tRNA(Leu) = cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu)", "d": []}, {"i": "EC:2.3.2.22", "l": "\"cyclo(L-leucyl-L-leucyl) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32833", "l": "an R-cob(III)alamin(out) => an R-cob(III)alamin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38224", "l": "(9Z)-octadecenoyl-CoA + decan-1-ol => 1-O-decyl-(9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034794", "l": "cyclopropanecarboxyl-CoA decyclase activity", "d": ["Catalysis of the reaction: cyclopropanecarboxyl-CoA = crotonoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34956", "l": "5-(methylsulfanyl)-D-ribose(in) => 5-(methylsulfanyl)-D-ribose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52012", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27426", "l": "(2E,6E)-farnesyl diphosphate => (E)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44821", "l": "1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-13 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29241", "l": "H(+)(out) + uracil(out) => H(+)(in) + uracil(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58718", "l": "FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal => FADH2-C4alpha-hydroperoxide + NADH + rifampicin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629166", "l": "Defective NEIL1 variants do not cleave Tg (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2471641", "l": "Defective OPN1MW causes COD5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22536", "l": "(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine = (S)-tetrahydropalmatine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.89", "l": "\"tetrahydrocolumbamine 2-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75320", "l": "chloride(out) + D-alanine(out) + 2 Na(+)(out) => chloride(in) + D-alanine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35841", "l": "a cardiolipin + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791131", "l": "Expression of PDIA6 (Protein disulfide-isomerase A6) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31972", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 => 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38144", "l": "carbon disulfide + 2 H2O => CO2 + 2 H(+) + 2 hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74219", "l": "H2O + L-seryl-tRNA(Thr) = L-serine + tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24925", "l": "2-oxobutanoate + NH4(+) => L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.39", "l": "\"alkylglycerophosphoethanolamine phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46235", "l": "(9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031770", "l": "growth hormone-releasing hormone receptor binding", "d": ["Binding to a growth hormone-releasing hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9015111", "l": "Factor Xa inhibitors binds Xa (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.200", "l": "\"tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44029", "l": "L-altrarate => 5-dehydro-4-deoxy-D-glucarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16278", "l": "H2O + indole-3-acetaldehyde + O2 => (indol-3-yl)acetate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74946", "l": "2-oxoglutarate + a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + O2 <=> a (3R)-3-isocyanyl-fatty acid + 2 CO2 + 2 H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49117", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate => deoxyviolaceinate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67114", "l": "H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374723", "l": "Nociceptin receptor binds to nociceptin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41154", "l": "1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29269", "l": "L-valine(out) + Na(+)(out) => L-valine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140945", "l": "histone H3K4 monomethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl4-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200406", "l": "CPT1A,B transfers PALM to CAR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21796", "l": "dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.133", "l": "\"dTDP-4-dehydrorhamnose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41326", "l": "(12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate => (5Z,8Z,11Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306876", "l": "NLRP3 activation by small molecules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59855", "l": "(2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH <=> (R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034056", "l": "estrogen response element binding", "d": ["Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51685", "l": "(2E,6E)-farnesyl phosphate + CTP => (2E,6E)-farnesyl diphosphate + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24248", "l": "glyoxylate + L-alanine = glycine + pyruvate", "d": []}, {"i": "EC:2.6.1.44", "l": "\"alanine--glyoxylate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1461995", "l": "pro-defensin alpha 5 is stored in Paneth cell granules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65889", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24781", "l": "C-13(2)-carboxypyropheophorbide a + H(+) => CO2 + pyropheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70485", "l": "a 2'-deoxyguanosine in single-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in single-stranded DNA + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28649", "l": "3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate => acetophenone + 2 ATP + H2O + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12710", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390641", "l": "ADRA1A,B,D bind ADR,NAd (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70544", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[protein] + UDP-alpha-D-glucose => 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071567", "l": "deUFMylase activity", "d": ["A thiol-dependent isopeptidase activity that cleaves UFM1 from a target protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63098", "l": "ilicicolin C => ilicicolin A epoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51165", "l": "cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036004", "l": "GAF domain binding", "d": ["Binding to a GAF protein domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44389", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA => 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805399", "l": "TAF1 phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.183", "l": "\"glycoprotein-mannosyl O(6)-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53721", "l": "ATP + N-acetyl-D-muramate => ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22663", "l": "a fatty acid + ATP + holo-[ACP] <=> a fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37306", "l": "ATP + glycyl-L-asparagine(out) + H2O <=> ADP + glycyl-L-asparagine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794349", "l": "NMDA receptor complex:DLG2,DLG3,DLG4 binds SPAR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937369", "l": "ATAD2 binds ESR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45818", "l": "AH2 + pyruvate => (S)-lactate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59286", "l": "D-glucose + N-octadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56203", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose <=> H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32327", "l": "10-hydroxy-alpha-humulene + NAD(+) = H(+) + NADH + zerumbone", "d": []}, {"i": "EC:1.1.1.326", "l": "\"zerumbone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54074", "l": "beta-thujene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102007", "l": "acyl-L-homoserine-lactone lactonohydrolase activity", "d": ["Catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone <=> H+ + an N-acyl-L-homoserine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74923", "l": "a (3R)-3-[(carboxymethyl)amino]fatty acid + H(+) + holo-[ACP] = a (2E)-enoyl-[ACP] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202168", "l": "Phosphorylation of ZAP-70 by Lck (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49711", "l": "nocardicin G + S-adenosyl-L-methionine <=> H(+) + isonocardicin C + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420883", "l": "Opsins act as GEFs for G alpha-t (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690493", "l": "RHOB binds effectors on endosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692738", "l": "HRH2 binds HRH2 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.242", "l": "\"Kdo2-lipid IVA palmitoleoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178215", "l": "SMAD7:SMURF1 complex is exported to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875817", "l": "MET phosphorylates STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086090", "l": "voltage-gated potassium channel activity involved in SA node cell action potential repolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48605", "l": "2,3-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] => 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71256", "l": "3 Na(+)(out) + phosphate(out) => 3 Na(+)(in) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684169", "l": "G6B binds PTPN6,PTPN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202328", "l": "Translocation of PKC theta to plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27306", "l": "A + D-proline = 1-pyrroline-2-carboxylate + AH2", "d": []}, {"i": "EC:1.5.99.13", "l": "\"D-proline dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47121", "l": "docosanoate + glycine => H2O + N-docosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64240", "l": "glycine + octanoyl-CoA = CoA + H(+) + N-octanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48283", "l": "ganglioside GM2 + UDP-alpha-D-galactose <=> ganglioside GM1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46950", "l": "N(7)-methyl-GTP + S-adenosyl-L-homocysteine => GTP + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48479", "l": "ganglioside GT1a (d18:1(4E)) + H2O <=> ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950766", "l": "IL27RA dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1638845", "l": "CERK phosphorylates CERA to form C1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65862", "l": "17beta-hydroxyandrostan-1,3-dione + AH2 => A + Delta(1)-dihydrotestosterone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73559", "l": "dGTP(out) + UTP(in) = dGTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2167942", "l": "Collagen type XIII ectodomain shedding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23157", "l": "(E)-(indol-3-yl)acetaldehyde oxime => (indol-3-yl)acetonitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047382", "l": "methylphosphothioglycerate phosphatase activity", "d": ["Catalysis of the reaction: S-methyl-3-phospho-1-thio-D-glycerate + H2O = S-methyl-1-thio-D-glycerate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102273", "l": "homophytochelatin synthase (dimmer forming) activity", "d": ["Catalysis of the reaction: glutathionate + L-gamma-glutamyl-L-cysteinyl-beta-alaninate <=> gamma-Glu-Cys-gamma-Glu-Cys-beta-Ala + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026912", "l": "GGT hydrolyses PCTR1 to PCTR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60895", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O <=> a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19841", "l": "H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.2.7.12", "l": "\"formylmethanofuran dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696822", "l": "AKR1B15 reduces EST17b to E1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202245", "l": "Phosphorylation of TBSMs in LAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.247", "l": "\"[methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73040", "l": "H(+)(out) + Ni(2+)(out) => H(+)(in) + Ni(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57416", "l": "H2O + L-asparaginyl-[protein] = L-aspartyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16294", "l": "2-isopropylmaleate + H2O => (2S)-2-isopropylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851866", "l": "MET binds RANBP10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66988", "l": "4-methylpentanoate + ATP + CoA = 4-methylpentanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13716", "l": "a ubiquinone + succinate <=> a ubiquinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19642", "l": "(E)-4-coumarate + ATP + CoA => (E)-4-coumaroyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65121", "l": "H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione => L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49730", "l": "CO2 + 2 H2O + NADP(+) + violacein => 2 H(+) + NADPH + 2 O2 + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76386", "l": "CYP1A2 S-demethylates 6MMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034783", "l": "pivalate-CoA ligase activity", "d": ["Catalysis of the reaction: pivalate + H+ + HSCoA + ATP = pivalyl-CoA + PPi + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007591", "l": "E2F6 binds RRM2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977375", "l": "CR1 binds C3bBb/C4bC2a (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45800", "l": "15-demethylaclacinomycin T + AH2 + O2 = 10-decarboxymethylaclacinomycin T + A + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938815", "l": "RNF152 polyubiquitinates RRAGA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392263", "l": "AVP(20-28) binds AVPR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24747", "l": "L-methionine => 2-aminobut-2-enoate + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16028", "l": "an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA <=> an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372697", "l": "Crk binding to p130cas (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682010", "l": "ATG10:ATG12 binds ATG5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102510", "l": "pelargonidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> anthocyanidin 3,5-di-O-beta-D-glucoside + vanillate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.4", "l": "\"phospholipase D\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28121", "l": "di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose <=> D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46168", "l": "ATP + CoA + pentanoate = AMP + diphosphate + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549129", "l": "OCT1 transports organic cations into hepatic cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68137", "l": "acetophenone + H(+) + NADPH => (R)-1-phenylethanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49248", "l": "galactitol(out) + N(pros)-phospho-L-histidyl-[protein] = galactitol 1-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.200", "l": "\"protein-N(pi)-phosphohistidine--galactitol phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912410", "l": "NOTCH4 mRNA translation controlled by miRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9703895", "l": "CASR binds CASR agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784494", "l": "EKC complex threonylcarbamoylates A37 of tRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250280", "l": "ROS oxidize thioredoxin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42991", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> cembrene C + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295613", "l": "SPRY2 binds GRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61652", "l": "2,3-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] = 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.71", "l": "\"2,3-dihydroxybenzoate--[aryl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.111", "l": "\"phosphatidylserine sn-1 acylhydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71102", "l": "androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) <=> androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22961", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] => calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16262", "l": "L-lysyl-[protein] + succinyl-CoA => CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14346", "l": "H(+) + L-tyrosine => CO2 + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033862", "l": "UMP kinase activity", "d": ["Catalysis of the reaction: ATP + UMP = ADP + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213239", "l": "Formation of MHC II alpha beta heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36628", "l": "2-hydroxytetracosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43201", "l": "cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53462", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate => 1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725338", "l": "NPM-ALK-dependent BCL2A1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-179417", "l": "Multiubiquitination of Nek2A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33013", "l": "(+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198314", "l": "DAG stimulates protein kinase C-delta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16529", "l": "ADP + H(+) + sulfate = adenosine 5'-phosphosulfate + phosphate", "d": []}, {"i": "EC:2.7.7.5", "l": "\"sulfate adenylyltransferase (ADP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55658", "l": "a carotenoid chi-end derivative + 2 AH2 => 2 A + a carotenoid beta-end derivative", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17055", "l": "beta-D-fructose 6-phosphate + D-erythrose 4-phosphate => D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708497", "l": "BACH1 gene produces BACH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22209", "l": "3-hydroxyphenylacetate + H(+) + NADH + O2 => H2O + homogentisate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70718", "l": "glycine(in) <=> glycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11195", "l": "an (S)-2-haloacid + H2O <=> a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17528", "l": "biuret + H2O <=> NH4(+) + urea-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41841", "l": "3-oxooctanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyoctanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450088", "l": "GLUT1 tetramer binds 4xATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32239", "l": "gamma-carotene = all-trans-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964280", "l": "Active Gq binds BTK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38624", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39952", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35504", "l": "11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209828", "l": "Tryptophan is hydroxylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9668335", "l": "CHMP7 binds LEMD2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35679", "l": "dodecanoyl-CoA + H(+) + L-serine = 3-oxotetradecasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74510", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B <=> (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213241", "l": "Formation of nonameric complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33757", "l": "(4R)-hydroxysphinganine + hexadecanoate => H2O + N-hexadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6794347", "l": "Homer1,2,3 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446391", "l": "Formation of the PINCH-ILK-parvin complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102935", "l": "gypsogenin-UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenin = gypsogenin-28-beta-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373342", "l": "CX3CR1 binds CX3CL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57633", "l": "ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68610", "l": "Formation of ORC(2-5) complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004831", "l": "tyrosine-tRNA ligase activity", "d": ["Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47034", "l": "2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein] => AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67751", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14979", "l": "3-carboxy-cis,cis-muconate => 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507868", "l": "Aquaporins passively transport water into cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201457", "l": "BMP2 binds to the receptor complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20780", "l": "ATP + GMP = ADP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647978", "l": "pro-RAS proteins are farnesylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102746", "l": "tetrahydrogeranylgeranyl-PP reductase activity", "d": ["Catalysis of the reaction: H+ + tetrahydrogeranylgeranyl-PP + NADPH = (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75841", "l": "H(+)(out) + K(+)(out) + Na(+)(in) + serotonin(in) => H(+)(in) + K(+)(in) + Na(+)(out) + serotonin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047196", "l": "long-chain-alcohol O-fatty-acyltransferase activity", "d": ["Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977363", "l": "Factor H binds to C3bBb (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49794", "l": "CoA + H(+) + N-eicosanoylglycinate => eicosanoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-398184", "l": "LARG activation by G alpha 12/13 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474266", "l": "Formation of collagen fibrils (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52255", "l": "a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-164617", "l": "Elongation of Extended Telomeric Chromosome End (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32360", "l": "1D-myo-inositol 1,4,5-trisphosphate + 2 ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038103", "l": "activin receptor antagonist activity involved in negative regulation of nodal signaling pathway", "d": ["Interacting with an activin receptor to reduce the action of the agonist nodal. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74356", "l": "a cytidine in mRNA + H(+) + H2O => a uridine in mRNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57915", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) <=> H(+) + L-glutaminyl-tRNA(Gln) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932021", "l": "RUNX1 and ESR1 bind the GPAM gene enhancer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69273", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate => allyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76426", "l": "N-atom dealkylation of caffeine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.843050782660015", "identifiers": [{"i": "GO:0005228", "l": "intracellular sodium activated potassium channel activity", "d": ["Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-741411", "l": "CYLD deubiquitinates NEMO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36474", "l": "3,4,5-trihydroxybenzoate(out) + H(+)(out) <=> 3,4,5-trihydroxybenzoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0016426", "l": "tRNA (adenine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methyladenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928654", "l": "Clathrin internalises EPH:EFN complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694522", "l": "Inner coat assembly and cargo binding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28752", "l": "sn-glycerol 3-phosphate + ubiquinone-8 => dihydroxyacetone phosphate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171122", "l": "LDL + LDLR => LDL:LDLR complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37592", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA => 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23033", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948034", "l": "FGR binds LDL:LRP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694409", "l": "Nucleotide exchange on RAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67374", "l": "L-serine + L-threonine => H2O + L-seryl-L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004980", "l": "melanocyte-stimulating hormone receptor activity", "d": ["Combining with melanocyte-stimulating hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66531", "l": "ATP + O-(5'-adenylyl)-L-tyrosyl-[protein] <=> diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-435244", "l": "PECAM1 is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46934", "l": "5-epi-valiolone 7-phosphate => 2-epi-5-epi-valiolone 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41317", "l": "1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937814", "l": "RUNX3 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36647", "l": "2-hydroxyhexadecanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67906", "l": "3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA => glutaryl-CoA + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814094", "l": "ARL1:GTP binds ARFIP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9736953", "l": "FURIN translocates to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389381", "l": "Gads binds CD28 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9646685", "l": "Aggresome dissociates from dynein and microtubule (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68962", "l": "7-hydroxy-8-methoxycoumarin + H(+) + S-adenosyl-L-homocysteine => 7,8-dihydroxycoumarin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.107", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63072", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + orcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034532", "l": "2-hydroxy-7-hydroxymethylchromene-2-carboxylate isomerase activity", "d": ["Catalysis of the reaction: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate = 2-hydroxy-4-hydroxymethylbenzalpyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186819", "l": "SH2 domain of Src binds to the active receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14407", "l": "D-glucono-1,5-lactone + H(+) + NADPH => D-glucose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11580", "l": "a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.11", "l": "\"CDP-diacylglycerol--inositol 3-phosphatidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688834", "l": "ATXN3 binds VCP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67248", "l": "(E)-4-hydroxynon-2-enal + H2O + NAD(+) = (E)-4-hydroxynon-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66990", "l": "4-methylpentanoyl-CoA + AMP + diphosphate => 4-methylpentanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52338", "l": "a long-chain fatty acyl-AMP + diphosphate => a long-chain fatty acid + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41690", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate => 1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36053", "l": "2 beta-L-arabinofuranose => beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67146", "l": "(1R,2R)-12-hydroxyjasmonate + CO2 + succinate => 2-oxoglutarate + jasmonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52596", "l": "lithocholoyl-CoA + NAD(+) = 3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047747", "l": "cholate-CoA ligase activity", "d": ["Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60115", "l": "(R)-3-(indol-3-yl)lactoyl-CoA <=> (E)-3-(indol-3-yl)acryloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20055", "l": "D-ribulose + H(+) + NADH => NAD(+) + ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30533", "l": "biotin + H2O + NAD(+) => biotinate sulfoxide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.10", "l": "\"chloride peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3785768", "l": "MRN complex binds DNA double strand breaks (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49893", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 => (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604731", "l": "Autocatalytic activation of MMP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0015116", "l": "sulfate transmembrane transporter activity", "d": ["Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20971", "l": "L-arabinonate <=> 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2731141", "l": "Syndecan-1 binds fibronectin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67856", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] = 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16696", "l": "alpha-pinene oxide <=> (Z)-2-methyl-5-isopropylhexa-2,5-dienal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981728", "l": "Factor H binds to membrane-associated C3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350769", "l": "trans-Golgi Network Coat Activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69194", "l": "ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate => ATP + L-glutamate + L-glutamyl-[tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22161", "l": "4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside => a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53584", "l": "NAD(+) + resolvin D2 = 7-oxoresolvin D2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17243", "l": "an alcohol + an alpha-amino acid + H(+) => an alpha-amino acid ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14859", "l": "ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate => (indol-3-yl)acetate + ATP + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64494", "l": "dehydrocitreoisocoumarin + H2O + holo-[ACP] => 3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375140", "l": "CDO binds promyogenic cadherins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788623", "l": "p-Y-STATs translocate to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42031", "l": "NAD(+) + ursodeoxycholate <=> 7-oxolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706354", "l": "Ubiquitination of FLT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21417", "l": "NADP(+) + sn-glycerol 1-phosphate => dihydroxyacetone phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.26", "l": "\"toluene methyl-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605768", "l": "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48168", "l": "H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine = N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51947", "l": "8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine <=> 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35439", "l": "CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine = archaetidylserine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40465", "l": "(9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+) => 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47282", "l": "4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004564", "l": "beta-fructofuranosidase activity", "d": ["Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20628", "l": "2 Fe(III)-[cytochrome c3] + H2 <=> 2 Fe(II)-[cytochrome c3] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.461014234140904", "identifiers": [{"i": "GO:0016279", "l": "protein-lysine N-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-844447", "l": "NLRP1 senses MDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110319", "l": "Elongation by POLH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204873", "l": "Interaction of Tie2 and Shp2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74016", "l": "4-hydroxybenzoate + H(+) + phosphate => CO2 + H2O + phenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191636", "l": "Phosphorylation of Cx43 by c-src (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018798", "l": "RHOV binds GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2176452", "l": "Degradation of ubiquitinated SMAD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0051428", "l": "peptide hormone receptor binding", "d": ["Binding to a receptor for a peptide hormone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141423", "l": "Binding of the MCC complex to the APC/C complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009015", "l": "N-succinylarginine dihydrolase activity", "d": ["Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H2O + 2 H+ = N(2)-succinyl-L-ornithine + CO2 + 2 NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785087", "l": "FANCM:FAAP24 and APITD1:STRA13 bind ICL-DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65067", "l": "dimethylallyl diphosphate + siccayne <=> diphosphate + pestalodiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51182", "l": "5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16776", "l": "ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GM1 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27542", "l": "methanol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68375", "l": "L-asparagine + pyruvate <=> 2-oxosuccinamate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69281", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate => 3-hydroxypropyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33380", "l": "4-hydroxyeicosasphinganine 1-phosphate + H2O => (4R)-hydroxyeicosasphinganine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35536", "l": "cyclo(L-phenylalanyl-L-leucyl) + O2 => cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25201", "l": "D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose 6-phosphate", "d": []}, {"i": "EC:4.1.2.43", "l": "\"3-hexulose-6-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21772", "l": "cytidine(6666) in apoB mRNA + H(+) + H2O = NH4(+) + uridine(6666) in apoB mRNA", "d": []}, {"i": "EC:3.5.4.36", "l": "\"mRNA(cytosine(6666)) deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15794", "l": "bilirubin IXalpha + NADP(+) => biliverdin IXalpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46719", "l": "pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227885", "l": "TBK1/IKK epsilon bind to TANK:TRAF3/TRAF6 complex followed by their activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193776", "l": "Efflux of 24-hydroxycholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9761027", "l": "ZEB2 binds SP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21851", "l": "(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide <=> (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018690", "l": "4-methoxybenzoate monooxygenase (O-demethylating) activity", "d": ["Catalysis of the reaction: 4-methoxybenzoate + AH(2) + O2 = 4-hydroxybenzoate + A + formaldehyde + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61422", "l": "cis-cis-nepetalactol => (S)-8-oxocitronellyl enol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21379", "l": "3-(4-hydroxyphenyl)pyruvate + O2 <=> (S)-4-hydroxymandelate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247960", "l": "Activation of p38 MAPK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73588", "l": "CTP(out) + UMP(in) => CTP(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70127", "l": "3-dehydro-6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0016753", "l": "O-sinapoyltransferase activity", "d": ["Catalysis of the transfer of a sinapoyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24875", "l": "D-serine + phosphate => H2O + O-phospho-D-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102873", "l": "1-18:1-2-16:0-digalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:0-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990605", "l": "GU repeat RNA binding", "d": ["Binding to an RNA molecule containing GU repeats."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40393", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + CoA => 1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65940", "l": "(R)-glycerate + GDP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065966", "l": "SREBP1A,1C,2 binds the TM7SF2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25544", "l": "ent-copalyl diphosphate = diphosphate + ent-pimara-9(11),15-diene", "d": []}, {"i": "EC:4.2.3.31", "l": "\"ent-pimara-9(11),15-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26103", "l": "cis-homoaconitate + H2O => (2R)-homocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0098632", "l": "cell-cell adhesion mediator activity", "d": ["The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65721", "l": "2-oxoglutarate + butyl sulfate + O2 => butanal + CO2 + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103085", "l": "2-(5'-methylthio)pentylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxo-7-methylthioheptanoate + acetyl-CoA + H2O <=> H+ + 2-(5'-methylthio)pentylmalate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10182", "l": "(6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH => (6S)-10-formyltetrahydrofolate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627106", "l": "SMAC (DIABLO) forms dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57303", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O <=> a 2'-deoxyguanosine in DNA + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73357", "l": "carcinine + H(+) + holo-[peptidyl-carrier protein] => beta-alanyl-[peptidyl-carrier protein] + histamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72610", "l": "(E)-sinapoyl-AMP + CoA <=> (E)-sinapoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-179421", "l": "Degradation of multiubiquitinated Nek2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34114", "l": "carboxyspermidine + H2O + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130619", "l": "TGN-lysosomal vesicle coat assembly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51502", "l": "ADP + H(+) + N-acetyl-D-muramate 6-phosphate => ATP + N-acetyl-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63160", "l": "H2O + N-(15Z-tetracosenoyl)-taurine = (15Z)-tetracosenoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36283", "l": "1,7-dimethylxanthine + H(+) + NADPH + O2 = 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12756", "l": "glycerol + NADP(+) <=> dihydroxyacetone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38420", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O => 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50350", "l": "a dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701147", "l": "TRPV1 binds TRPV1 blockers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17119", "l": "ADP + H(+) + N(5)-methyl-L-glutamine + phosphate => ATP + L-glutamate + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32881", "l": "(1R,4R)-bornane-2,5-dione + H(+) + NADH => (1R,4R,5R)-5-hydroxycamphor + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0051448", "l": "gonadotropin-releasing hormone binding", "d": ["Binding to gonadotropin-releasing hormone (GnRH), a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48137", "l": "ganglioside GM3 + H2O => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64018", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+) => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798748", "l": "Exocytosis of secretory granule lumen proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49478", "l": "H(+) + L-2-aminoadipate + NADH => 2 H2O + L-1-piperideine-6-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21204", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester", "d": []}, {"i": "EC:2.3.1.43", "l": "\"phosphatidylcholine--sterol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4647593", "l": "EP400 binds CDKN1A promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514831", "l": "Fibrillin-1 degradation by MMP14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029268", "l": "Phosphorylation and activation of PLCG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60243", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40429", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191402", "l": "Reduction of presqualene diphosphate to form squalene (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49448", "l": "beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O = alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose", "d": []}, {"i": "EC:3.2.1.197", "l": "\"beta-1,2-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848864", "l": "PTK6 binds ARAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659998", "l": "Defective TALDO1 does not transform Fru(6)P, E4P to SH7P, GA3P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47222", "l": "3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448632", "l": "IL34 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72305", "l": "L-glutamate(out) + L-thyroxine(in) => L-glutamate(in) + L-thyroxine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008692", "l": "IL37(?-218) binds SMAD3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381337", "l": "Expression of CEBPB in adipogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102795", "l": "1-naphthaldehyde:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: 1-naphthaldehyde + O2 + H2O = H+ + 1-naphthoate + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36184", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15000", "l": "deoxylimonoate + H2O <=> deoxylimononate D-ring-lactone + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43471", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (8Z,10E,14Z)-12-hydroperoxyeicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74918", "l": "a (2E)-enoyl fatty acid + ATP + H(+) <=> a (2E)-2-fatty-enoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632652", "l": "Hh-Npp binds CDON and PTCH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64864", "l": "ITP + oxaloacetate = CO2 + IDP + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43722", "l": "juvenile hormone III + S-adenosyl-L-homocysteine => juvenile hormone III carboxylate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40686", "l": "1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol <=> 1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42173", "l": "(11Z)-eicosenoyl-CoA + AH2 + O2 => (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380316", "l": "Association of NuMA with microtubules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71880", "l": "2'-deoxyguanosine + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-2'-deoxyguanosine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694522", "l": "Inner coat assembly and cargo binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852317", "l": "PLK1 phosphorylates GTSE1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62903", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68905", "l": "3-phenylpropanoate + ATP + H(+) + NADPH => 3-phenylpropanal + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165131", "l": "GEF dissociates from DRheb-GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17867", "l": "6,7-dihydropteridine + H(+) + NADPH => 5,6,7,8-tetrahydropteridine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31708", "l": "2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2299620", "l": "Collagen XI cross-links with collagen II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28382", "l": "H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine = D-glucose 6-phosphate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022911", "l": "CSPG is secreted (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849908", "l": "SALM4 binds flotillin-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196773", "l": "COASY phosphorylates DP-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420977", "l": "Ca permeable AMPA receptor ligand binding (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770141", "l": "Formation of the Spliceosomal C* complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628901", "l": "TP53 stimulates TIGAR expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40499", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299297", "l": "Activation of THIK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19300", "l": "ATP + beta-alanine + L-histidine <=> ADP + carnosine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088134", "l": "PLK1 phosphorylates FOXM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004820", "l": "glycine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76456", "l": "O-atom dealkylation of dextromethorphan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047174", "l": "putrescine N-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: caffeoyl-CoA + putrescine = N-caffeoylputrescine + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6795473", "l": "PDPK1 phosphorylates SGK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951499", "l": "Loading of antigenic peptides on to class I MHC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683831", "l": "CCDC59 binds TTF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205649", "l": "p62 links damaged mitochondria to LC3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72251", "l": "(R)-adrenaline + S-adenosyl-L-methionine = (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874718", "l": "TTPA binds alpha-TOH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15490", "l": "adenosine + H2O + 2 O2 => 9-riburonosyladenine + H(+) + 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71851", "l": "glycocholate(out) = glycocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693243", "l": "RHOD translocates to the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42678", "l": "H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide => L-cysteine + L-histidine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62735", "l": "(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) <=> (+)-isomalbrancheamide D + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32862", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174157", "l": "Degradation of multiubiquitinated Cyclin B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24441", "l": "ATP + H2O + phosphate(out) => ADP + H(+) + 2 phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944247", "l": "Association of procollagen type VI (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987039", "l": "JAK1 binds IL20RA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627106", "l": "SMAC (DIABLO) forms dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69441", "l": "3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) => 3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32982", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a fatty acid + H(+) + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18537", "l": "H2O + NAD(+) + salicylaldehyde = 2 H(+) + NADH + salicylate", "d": []}, {"i": "EC:1.2.1.65", "l": "\"salicylaldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9006870", "l": "IL21 receptor STAT phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44120", "l": "hexadecanoyl-CoA + octadecan-1-ol = CoA + octadecanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004803", "l": "transposase activity", "d": ["Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-179417", "l": "Multiubiquitination of Nek2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12868", "l": "1-methyladenosine + H2O <=> 1-methyladenine + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72666", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-phenylalanyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34132", "l": "neryl diphosphate + olivetolate => cannabinerolate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102564", "l": "aurachin C epoxide hydrolase/isomerase activity", "d": ["Catalysis of the reaction: aurachin C epoxide + H+ + NAD(P)H <=> aurachin B + H2O + NAD(P)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26430", "l": "(+)-copalyl diphosphate + H2O = diphosphate + phyllocladan-16alpha-ol", "d": []}, {"i": "EC:4.2.3.45", "l": "\"phyllocladan-16alpha-ol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30115", "l": "decanoyl-[ACP] + H2O = decanoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19936", "l": "alpha-D-glucose 1-phosphate + H2O <=> D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29930", "l": "(R)-pantothenate(in) + Na(+)(in) <=> (R)-pantothenate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20874", "l": "(20S)-ginsenoside Rb1 + H(+) + UDP => (20S)-ginsenoside Rd + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669024", "l": "CD70 binds CD27 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29308", "l": "FMNH2 + methanesulfonate + O2 => FMN + formaldehyde + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209910", "l": "Iodide is taken up by thyroid epithelial cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17996", "l": "ATP + beta-alanine + gamma-L-glutamyl-L-cysteine <=> ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72631", "l": "Formation of the cap-binding eIF4F complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49438", "l": "choloyl-CoA + deoxycholate => cholate + deoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51035", "l": "7-chloroindole-3-pyruvate imine dimer <=> dichlorochromopyrrolate + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59028", "l": "(Z)-24-ethylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624952", "l": "Assembly of the retrograde IFT train (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26555", "l": "angiotensin II + H2O => angiotensin-(1-7) + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168848", "l": "tBID binds to inactive BAK protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75909", "l": "ADP + H(+) + O-(L-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein] => ADP-L-glycero-beta-D-manno-heptose + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686663", "l": "Completion of SSA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029270", "l": "Recruitment of PLCgamma to membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654651", "l": "Activated FGFR4 binds FRS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54912", "l": "11-cis-retinol + NADP(+) = 11-cis-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712079", "l": "ALK mutants bind STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22447", "l": "(E)-coniferol + NADP(+) <=> (E)-coniferaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786155", "l": "POLN binds ICL-DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106009", "l": "(4S)-4-hydroxy-2-oxoglutarate aldolase activity", "d": ["Catalysis of the reaction:(4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59145", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466834", "l": "Defective OPN1SW causes tritanopia (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015142", "l": "tricarboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of tricarboxylic acids from one side of a membrane to the other. Tricarboxylic acid are organic acids with three COOH groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37542", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653936", "l": "Formation of Ragulator complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47368", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose = a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.345", "l": "\"phosphatidyl-myo-inositol alpha-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0001098", "l": "basal transcription machinery binding", "d": ["Binding to a component of the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30437", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74617", "l": "UDP-alpha-D-galactose(out) + UDP-alpha-D-glucose(in) => UDP-alpha-D-galactose(in) + UDP-alpha-D-glucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043184", "l": "vascular endothelial growth factor receptor 2 binding", "d": ["Binding to a vascular endothelial growth factor receptor 2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9640167", "l": "RRAGA,B exchanges GDP for GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75514", "l": "acetyl-CoA + S-benzyl-L-cysteine <=> CoA + H(+) + N-acetyl-S-benzyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709454", "l": "EPOR binds EPOR agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709179", "l": "DPP4 binds DPP4 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43904", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol = all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26321", "l": "resorcinol + S-adenosyl-L-methionine = 3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.n1", "l": "\"resorcinol O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174235", "l": "Association of Emi1 with Cdc20 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.3.-", "l": "\"With H(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37605", "l": "1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044012", "l": "histone H2AK9 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 9) = CoA + histone H2A N6-acetyl-L-lysine (position 9)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368087", "l": "RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193399", "l": "Cholate is translocated from the peroxisomal matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19675", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) => 1,2,3-trihydroxybenzene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62502", "l": "AMP + H(+) + L-arginyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-arginyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17307", "l": "dimethylamine + L-citrulline => H2O + N(omega),N(omega)-dimethyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37610", "l": "(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396370", "l": "VTN binds collagens II, III and V (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211219", "l": "Translocation of caspase-3 to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168982", "l": "Collagen type XVI degradation by MMP9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18800", "l": "a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67429", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004159", "l": "dihydropyrimidine dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: a 5,6-dihydropyrimidine (5,6-dihydrouracil or 5,6-dihydrothymine) + NAD+ = a pyrimidine (uracil or thymine) + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68603", "l": "(2S)-3-sulfopropanediol <=> 3-oxopropane-1-sulfonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50907", "l": "L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220610", "l": "Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29942", "l": "H(+)(in) + phosphate(in) <=> H(+)(out) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59510", "l": "S-(2-succinyl)-L-cysteinyl-[protein] => fumarate + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388808", "l": "CD28 homodimer binds B7-2 monomer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51945", "l": "8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine => 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018702", "l": "1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity", "d": ["Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + H+ + 2 e- = Cl- + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene is also known as DDE; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45269", "l": "4'-hydroxyechinenone + AH2 + O2 => 4',4'-dihydroxyechinenone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51913", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71849", "l": "LDH tetramer reduces PYR to LACT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29646", "l": "D-maltoheptaose + H2O <=> alpha-D-glucose + D-maltohexaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15880", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate <=> D-glutamate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65356", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50492", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350395", "l": "RHOGDI binds to and sequesters RHO1:GDP complex to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59613", "l": "beta-alanyl-L-ornithine + H2O => beta-alanine + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58042", "l": "(9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+) => 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796617", "l": "MIB2 binds CFLAR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17970", "l": "ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036357", "l": "2-phosphoglycerate kinase activity", "d": ["Catalysis of the reaction: 2-phosphoglycerate + ATP = 2,3-diphosphoglycerate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23555", "l": "2-methylpropane-1,2-diol + NAD(+) <=> 2-hydroxy-2-methylpropanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052638", "l": "indole-3-butyrate beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: indole-3-butyrate + UDP-D-glucose = indole-3-butyryl-beta-1-D-glucose + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708866", "l": "pro-F2R binds vorapaxar (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70692", "l": "ornithine => putrescine + CO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20886", "l": "3-hydroxypyruvate + H(+) + NADH + NH4(+) => H2O + L-serine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75669", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate => (11Z,14Z,17Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24733", "l": "anthranilate + H(+) <=> aniline + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48356", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69535", "l": "(2S)-2-amino-4-deoxychorismate <=> 4-amino-4-deoxychorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201608", "l": "Caspase-mediated cleavage of alpha adducin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451418", "l": "Pellino ubiquitinates IRAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51717", "l": "ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47682", "l": "D-tagatopyranose 1-phosphate + NH4(+) => D-galactosamine 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27595", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 5 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51442", "l": "(11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34293", "l": "2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP => 2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686336", "l": "SARS-CoV-1 3a oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5622129", "l": "FABP5 binds atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63131", "l": "H2O + N-docosanoyl-ethanolamine <=> docosanoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66571", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O <=> preluffariellolide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54122", "l": "coelenterazine h dioxetanone => coelenterazine h + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19861", "l": "a 16alpha-hydroxysteroid + NAD(+) = a 16-oxosteroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69127", "l": "Formation of the Flap Intermediate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57917", "l": "ATP + L-aspartyl-tRNA(Asn) => 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940032", "l": "TWIST1 binds the RUNX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2002466", "l": "Formation of allysine by LOX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375151", "l": "Interaction of NCAM1 with collagens (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173680", "l": "Activation of C5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173740", "l": "Factor B binds to C3(H2O) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69667", "l": "H2O + luteolin 4'-O-beta-D-glucoside = beta-D-glucose + luteolin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11731", "l": "cyclopentanol + NAD(+) <=> cyclopentanone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43915", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10056", "l": "(3S)-3-aminobutanoyl-CoA = (2E)-butenoyl-CoA + NH4(+)", "d": []}, {"i": "EC:4.3.1.14", "l": "\"3-aminobutyryl-CoA ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73577", "l": "CAD hexamer transforms L-Gln to CAP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.98", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47316", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177930", "l": "GAB1 phosphorylation by EGFR kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033934", "l": "glucan 1,4-alpha-maltotriohydrolase activity", "d": ["Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotriose residues from the non-reducing chain ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40702", "l": "1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol <=> 1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33397", "l": "GMP + N(alpha)-acetyl-L-lysine methyl ester => H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59204", "l": "docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036380", "l": "UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047837", "l": "D-xylose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-xylose + NADP+ = D-xylono-1,5-lactone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73597", "l": "CTP(in) + dUMP(out) => CTP(out) + dUMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61911", "l": "2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol <=> 2 AMP + asperphenamate + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007606", "l": "E2F6 binds BRCA1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23238", "l": "H(+) + L-glutamyl-[protein] + methanol => [protein]-L-glutamate 5-O-methyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706354", "l": "Ubiquitination of FLT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19431", "l": "[beta-adrenergic receptor]-phosphate + ADP + H(+) => [beta-adrenergic receptor] + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60985", "l": "16-hydroxyhexadecanoate + NAD(+) => 16-oxohexadecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49897", "l": "(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate => 5,10-dihydrophenazine-1,6-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32805", "l": "ADP + H(+) + phosphate + urea(in) => ATP + H2O + urea(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60632", "l": "all-trans-4-oxoretinol + NAD(+) = all-trans-4-oxoretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10351", "l": "5-oxo-L-proline + ATP + 2 H2O <=> ADP + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58798", "l": "a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA => a flavonol 7-O-beta-D-glucoside + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781840", "l": "ERCC6 binds stalled RNA Pol II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23833", "l": "an N-acyl-D-mannosamine + ATP => ADP + an N-acyl-D-mannosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030373", "l": "high molecular weight B cell growth factor receptor activity", "d": ["Combining with a high molecular weight B cell growth factor and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52594", "l": "12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH => deoxycholoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193642", "l": "Binding of pro-NGF to p75NTR:sortilin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9733973", "l": "Bile salts bind FABP6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373342", "l": "CX3CR1 binds CX3CL1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31299", "l": "H2O + NAD(+) + perillyl aldehyde = 2 H(+) + NADH + perillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661425", "l": "BIL:ALB dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58581", "l": "dihydroprecondylocarpine acetate => acetate + catharanthine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.45", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140849", "l": "ATP-dependent H2AZ histone chaperone activity", "d": ["A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers and remove H2A-H2B, while others do the opposite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59869", "l": "4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine => 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42363", "l": "D-allulose <=> keto-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:1990599", "l": "3' overhang single-stranded DNA endodeoxyribonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within 3' overhang single-stranded deoxyribonucleic acid by creating internal breaks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981926", "l": "RAC1 and CDC42 activate PAK3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209903", "l": "Noradrenaline is converted to adrenaline (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11192", "l": "an (S)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40001", "l": "a fatty aldehyde + phosphoethanolamine => a sphingoid 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25442", "l": "delta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47259", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37566", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944227", "l": "Association of procollagen type XXII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58084", "l": "1-(13Z-docosenoyl)-glycerol + H2O = (13Z)-docosenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45583", "l": "D-galactaro-1,5-lactone <=> D-galactaro-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27647", "l": "inosine + phosphate => alpha-D-ribose 1-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691004", "l": "XPC binds RAD23 and CETN2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395801", "l": "Phosphorylation of LAT by p-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371582", "l": "HSBP1 binds HSF1 trimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754129", "l": "CDK6 inhibitors bind CDK6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857555", "l": "EGFR phosphorylates GPNMB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848077", "l": "PTK6 phosphorylates STAP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0051015", "l": "actin filament binding", "d": ["Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.32", "l": "\"stem bromelain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805943", "l": "S100A1 binds TLR4:LY96 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665989", "l": "DIAPH1 binds RHOA:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58234", "l": "H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein] => L-seryl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65556", "l": "globoside GalGb4Cer + H2O = an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62391", "l": "[(1->2)-beta-D-glucosyl](n) + H2O <=> [(1->2)-beta-D-glucosyl](n-2) + sophorose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202375", "l": "Recruitment of ITK to SLP-76 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38430", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16665", "l": "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate", "d": []}, {"i": "EC:3.3.2.7", "l": "\"hepoxilin-epoxide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421472", "l": "2 delta-aminolevulinate => porphobilinogen + 2 H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.222", "l": "\"O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756724", "l": "p-2S-SMAD2,3:TRIM33, p-2S-SMAD2,3:SMAD4, CTNNB1, EOMES, and TBPL2 bind FOXH1:MIXL1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37704", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12812", "l": "4 catechol + 3 O2 <=> 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68632", "l": "3 H(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:7.1.1.11", "l": "\"ferredoxin--NAD(+) oxidoreductase (H(+)-transporting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57564", "l": "(+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41228", "l": "(S)-4-hydroxymandelate + O2 => 4-hydroxyphenylglyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23495", "l": "UDP-alpha-D-glucosamine <=> UDP-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73506", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine <=> 3',4,7-trihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52216", "l": "[(1''->2')-ADP-alpha-D-ribose](n) + H2O = [(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose", "d": []}, {"i": "EC:3.2.1.143", "l": "\"poly(ADP-ribose) glycohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.240751554780076", "identifiers": [{"i": "GO:0016417", "l": "S-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168459", "l": "Lyn activates ERK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51201", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine => H2O + N-retinylidene-N-retinylphosphatidylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24324", "l": "6-oxocineole + H(+) + NADPH + O2 = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.51", "l": "\"6-oxocineole dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847534", "l": "RAB43 hydrolyses GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25184", "l": "acetyl-CoA + putrescine <=> CoA + H(+) + N-acetylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32497", "l": "(6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28344", "l": "dIMP + diphosphate + H(+) => dITP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36712", "l": "ATP + H(+) + H2O + O-ureido-D-serine => ADP + CO2 + D-cycloserine + NH4(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50895", "l": "a menaquinone + 2 H(+) + hydrogen sulfide + sulfite <=> a menaquinol + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71497", "l": "6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out) => 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67117", "l": "N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6783670", "l": "CRLF1 binds CLCF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30689", "l": "glyoxylate + pyruvate => (4R)-4-hydroxy-2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391936", "l": "EP1 receptor can bind PGE2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65834", "l": "A + ADP + 2 Co(I)-[dimethylamine-specific corrinoid protein] + 3 H(+) + phosphate => AH2 + ATP + 2 Co(II)-[dimethylamine-specific corrinoid protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102180", "l": "4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 + H+ <=> 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60972", "l": "hexan-1-ol + NAD(+) = H(+) + hexanal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805479", "l": "TP53RK phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30978", "l": "15-cis-phytoene + 5 A <=> 5 AH2 + all-trans-3,4-didehydrolycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20052", "l": "1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O <=> 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202222", "l": "Phosphorylation of PKC theta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73945", "l": "FAS-mediated dimerization of procaspase-8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199144", "l": "Nectin 2 binds CD226 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63091", "l": "a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062206", "l": "manoyl oxide synthase activity", "d": ["Catalysis of the reaction: 8-hydroxycopalyl diphosphate = (13R)-manoyl oxide + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68953", "l": "isoscopoletin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + scoparone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983421", "l": "Journey of cargo through Golgi complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52834", "l": "7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => 1-hydroxylimonen-2-one + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50914", "l": "4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+) => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174438", "l": "Formation of the Flap Intermediate on the C-strand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029270", "l": "Recruitment of PLCgamma to membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64832", "l": "3-hydroxybenzyl alcohol + benzoyl-CoA = 3-hydroxy-benzyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13291", "l": "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP => a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51734", "l": "H(+) + meleagrin + S-adenosyl-L-homocysteine => glandicoline B + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53941", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 => 18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74061", "l": "beta-alanine(in) + L-alanine(out) => beta-alanine(out) + L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64336", "l": "H(+) + 2 malonyl-CoA + nicotinyl-CoA = 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59558", "l": "H(+) + N,N'-diacetylchitobionate => H2O + N,N'-diacetylchitobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51774", "l": "4-prenylphlorisobutanophenone + diphosphate => dimethylallyl diphosphate + phlorisobutanophenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811454", "l": "MAPKs phosphorylate PP2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71783", "l": "MDH2 reduces OA to MAL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49468", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose = a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48846", "l": "5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51793", "l": "H(+) + NADH + O2 + salicylate => 2,3-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0000049", "l": "tRNA binding", "d": ["Binding to a transfer RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61841", "l": "brassicasterol + UDP-alpha-D-glucose => brassicasterol 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21339", "l": "NAD(+) + pyridoxal <=> 4-pyridoxolactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106274", "l": "NAD+-protein-arginine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.61", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1861789", "l": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110236", "l": "OGG1 glycosylase mediated recognition and binding of a formamidopyrimidine (FapyG) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030507", "l": "spectrin binding", "d": ["Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70904", "l": "(2R)-3-phospho-glyceroyl phosphate + 2-deoxy-alpha-D-ribose 1-phosphate => (2R)-3-phosphoglycerate + 2-deoxy-alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212222", "l": "PRC2 recruits DNA methyltransferases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23916", "l": "H(+) + UDP-alpha-D-glucuronate = CO2 + UDP-alpha-D-xylose", "d": []}, {"i": "EC:4.1.1.35", "l": "\"UDP-glucuronate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388605", "l": "POMC(138-176) binds MC2R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382058", "l": "Nck binds to the active PDGF receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35785", "l": "H(+) + kanamycin B + UDP => neamine + UDP-alpha-D-kanosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15903", "l": "(2R)-3-phosphoglycerate => (2R)-2-phosphoglycerate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74172", "l": "an N-methyl carbamate ester + H(+) + H2O => an alcohol + CO2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48655", "l": "lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69819", "l": "H(+) + hypotaurine + NADPH + O2 = H2O + NADP(+) + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42151", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51681", "l": "(2E,6E)-farnesol + CTP => (2E,6E)-farnesyl phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32439", "l": "(+)-epi-isozizaene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = albaflavenone + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.39", "l": "\"epi-isozizaene 5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63050", "l": "H(+) + pravastatin => H2O + pravastatin lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51297", "l": "a quinone + H2O + L-methionyl-[protein] => a quinol + L-methionyl-(R)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981353", "l": "RASA1 stimulates RAS GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0001882", "l": "nucleoside binding", "d": ["Binding to a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0035727", "l": "lysophosphatidic acid binding", "d": ["Binding to lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54878", "l": "(3S)-3-isopropenyl-6-oxoheptanoate + H(+) => (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047964", "l": "glyoxylate reductase (NAD+) activity", "d": ["Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696670", "l": "CHD1L is recruited to GG-NER site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.187403162058388", "identifiers": [{"i": "GO:0016638", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}, {"i": "EC:1.4.-.-", "l": "\"Acting on the CH-NH2 group of donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76032", "l": "2-oxoglutarate + O2 + thebaine => 3-O-demethylthebaine + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018758", "l": "RHOH binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39118", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) <=> 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16819", "l": "6-phospho-2-dehydro-D-gluconate + H(+) + NADPH => 6-phospho-D-gluconate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37895", "l": "H2O + protodioscin = 26-deglucoprotodioscin + D-glucose", "d": []}, {"i": "EC:3.2.1.186", "l": "\"protodioscin 26-O-beta-D-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0019864", "l": "IgG binding", "d": ["Binding to an immunoglobulin of an IgG isotype."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11891", "l": "an aldehyde + H2O + NADP(+) <=> a carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69791", "l": "D-phenylalanyl-tRNA(Phe) + H2O = D-phenylalanine + H(+) + tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050389", "l": "uronolactonase activity", "d": ["Catalysis of the reaction: D-glucurono-6,2-lactone + H2O = D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047856", "l": "dihydrocoumarin hydrolase activity", "d": ["Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl)propanoate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714483", "l": "RAC2 translocates to the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814764", "l": "Plasma membrane resorption (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26196", "l": "(S)-malate + ATP + CoA <=> (S)-malyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62862", "l": "7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O => acetyl-CoA + 7 H(+) + 7 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.61", "l": "\"alpha-dystroglycan beta1,4-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16520", "l": "(R)-1-aminopropan-2-ol + NAD(+) <=> aminoacetone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36658", "l": "desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine <=> descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54223", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene <=> all-trans-neurosporene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-921155", "l": "p-STAT5 dissociates from the receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0140597", "l": "protein carrier chaperone", "d": ["Binding to and carrying a protein between two different cellular components by moving along with the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046175", "l": "Further sulfation on galactose residues produces KSPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5218821", "l": "PDK1 phosphorylates PKC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11725", "l": "[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite => 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59996", "l": "3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein] = (E)-cinnamate + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050224", "l": "prunasin beta-glucosidase activity", "d": ["Catalysis of the reaction: (R)-prunasin + H2O = D-glucose + mandelonitrile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37567", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38796", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50528", "l": "acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30302", "l": "2-oxoglutarate + a methylated nucleobase within DNA + O2 <=> a nucleobase within DNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030165", "l": "PDZ domain binding", "d": ["Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67116", "l": "N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035226", "l": "glutamate-cysteine ligase catalytic subunit binding", "d": ["Binding to the catalytic subunit of glutamate-cysteine ligase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174967", "l": "NAT2 acetylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9749253", "l": "Formation of MCM2-7 complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416698", "l": "SEMA5A binds to PLXNB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40472", "l": "(2S)-methylpentadecanoyl-CoA + O2 => 2-methyl-(2E)-pentadecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109857", "l": "MAP2K1 binds MAPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2203479", "l": "STAB2 (FEEL-2) binds ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16889", "l": "2-oxoglutarate + 6-acetamido-3-aminohexanoate = 6-acetamido-3-oxohexanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.65", "l": "\"N(6)-acetyl-beta-lysine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093329", "l": "EFNBs bind SDCBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052613", "l": "canthaxanthin 3-hydroxylase activity", "d": ["Catalysis of the reaction: canthaxanthin + a reduced electron acceptor + oxygen = adonirubin + an oxidized electron acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13009", "l": "H2O + N-formyl-L-kynurenine = formate + H(+) + L-kynurenine", "d": []}, {"i": "EC:3.5.1.9", "l": "\"arylformamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350475", "l": "FLW:MBS complex dephosphorylates SQH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59103", "l": "diglucosyl-enterobactin + UDP-alpha-D-glucose <=> H(+) + triglucosyl-enterobactin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44791", "l": "2-demethylmenaquinol-11 + S-adenosyl-L-methionine <=> H(+) + menaquinol-11 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35186", "l": "5-hydroxythiophene-2-carbonyl-CoA + H2O <=> 4-carboxy-2-thioxobutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247847", "l": "WLS is endocytosed to the early endosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701507", "l": "PTPN6 dephosphorylates JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60422", "l": "[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+) => H2O + triglucosyl-enterobactin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59959", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate <=> a nitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57332", "l": "H2O + 3 O2 + 3 propionate 3-nitronate = 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47181", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) => (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249378", "l": "STING recruits TBK1 and STAT6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174070", "l": "Association of Cdh1 with the APC/C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445714", "l": "Aquaporin-3 passively transports water out of cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949703", "l": "SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420365", "l": "Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163320", "l": "Association of mTERF with the termination sequence (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679775", "l": "COMT binds COMT Inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420117", "l": "VEGFR2 autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12114", "l": "(R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine => indole-3-pyruvate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42040", "l": "ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose = gangliosideFuc-GM1 (d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10729", "l": "GDP-6-deoxy-alpha-D-talose + NAD(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0015035", "l": "protein-disulfide reductase activity", "d": ["Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166015", "l": "Association of LBP with LPS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944261", "l": "Association of procollagen type XIII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62882", "l": "(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A => 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33468", "l": "5-dehydroepisterol + H(+) + NADPH + O2 => ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15212", "l": "(2R,3R)-tartrate + NAD(+) <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48461", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => 2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658430", "l": "NF1 is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18433", "l": "cyclohexylamine + H2O + O2 = cyclohexanone + H2O2 + NH4(+)", "d": []}, {"i": "EC:1.4.3.12", "l": "\"cyclohexylamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72578", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O <=> (22R)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43115", "l": "(R)-mandelate + NAD(+) <=> H(+) + NADH + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71631", "l": "phosphate(in) + sulfate(out) = phosphate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15770", "l": "adenosylcob(III)inamide + ATP => adenosylcob(III)inamide phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685602", "l": "NCR3LG1 binds NCR3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12970", "l": "a sn-glycero-3-phosphodiester + H2O => an alcohol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13319", "l": "(R)-glycerate + CO2 => (2R,3R)-tartrate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10929", "l": "ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43545", "l": "ATP + L-glutamate + tyramine => ADP + gamma-L-glutamyltyramine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56868", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA = (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA", "d": []}, {"i": "EC:2.3.1.273", "l": "\"diglucosylglycerate octanoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944454", "l": "mTORC1 phosphorylates MAF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65903", "l": "3-hydroxy-L-kynurenine + glyoxylate <=> glycine + H2O + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13160", "l": "(R)-glycerate + CO2 + NADP(+) <=> 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20238", "l": "(1S,4S)-5-oxo-1,2-campholide => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352059", "l": "SLC6A15-mediated amino acid uptake (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25145", "l": "3-hydroxyanthranilate + H(+) + L-alanine => 3-hydroxy-L-kynurenine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15575", "l": "H(+) + melatonin + S-adenosyl-L-homocysteine => N-acetylserotonin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928625", "l": "PAKs autophosphorylate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54115", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + selina-4(15),7(11)-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982765", "l": "Growth hormone forms dimers and oligomers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25681", "l": "ATP + O-phospho-L-serine + tRNA(Cys) <=> AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033949", "l": "fructan beta-(2,6)-fructosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing (2->6) linked beta-D-fructofuranose residues in fructans."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016677", "l": "oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group."]}, {"i": "EC:1.9.6.-", "l": "\"With a nitrogenous group as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110244", "l": "Excision of FapyG by OGG1 glycosylase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69544", "l": "ATP + streptidine = 6-O-adenylylstreptidine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10302", "l": "(2R)-3-phospho-glyceroyl phosphate + H(+) + NADH => D-glyceraldehyde 3-phosphate + NAD(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40066", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O <=> 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67136", "l": "3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69692", "l": "ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine => ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50317", "l": "ethyl octadecanoate + H2O => ethanol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27427", "l": "(E)-beta-farnesene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018804", "l": "RAC3 GEFs activate RAC3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692755", "l": "CDK1 phosphorylates MAPK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17554", "l": "ATP + guanidinoethyl methyl phosphate => ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32981", "l": "a fatty acid + H(+) + sn-glycero-3-phospho-L-serine => a 1-acyl-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32084", "l": "CTP + pseudaminate => CMP-pseudaminate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875558", "l": "RAPGEF1 binds CRK,CRKL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45819", "l": "(S)-lactate + A <=> AH2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52648", "l": "H2O + L-arabino-1,4-lactone 5-phosphate = 5-phospho-L-arabinonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67859", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] <=> 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.140", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47192", "l": "coenzyme M + methyl-Co(III)-[methylated-thiol-specific corrinoid protein] = Co(I)-[methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450975", "l": "isocitrate <=> citrate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50555", "l": "prostaglandin C1 <=> prostaglandin B1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9625482", "l": "PTK2 binds activated EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69746", "l": "(S)-2-benzylsuccinate + succinyl-CoA <=> (S)-2-benzylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610732", "l": "GSK3 phosphorylates p-GLI3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30911", "l": "a sphingomyelin + H2O = a carboxylate + sphing-4-enine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47500", "l": "cholate + NADP(+) = 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12057", "l": "D-erythrose 4-phosphate + H2O + NAD(+) => 4-phospho-D-erythronate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39675", "l": "(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57172", "l": "(S)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140810", "l": "histone H1R54 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H1 L-arginyl (position 54)= histone H1 L-citrullyl (position 54) + NH4+, resulting in histone H1 citrullination at position 54."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46991", "l": "(R)-6-hydroxynicotine + O2 <=> 6-hydroxy-N-methylmyosmine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66066", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate => 2-oxohexanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692749", "l": "CDC14A,B bind MAPK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75988", "l": "a dicarboxylate(in) + indoxyl sulfate(out) => a dicarboxylate(out) + indoxyl sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36406", "l": "a cholesterol ester + H2O <=> a fatty acid + cholesterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68065", "l": "a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH--hemoprotein reductase] => a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047518", "l": "1-methyladenosine nucleosidase activity", "d": ["Catalysis of the reaction: 1-methyladenosine + H2O = 1-methyladenine + ribofuranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37288", "l": "ATP + H2O + L-alanyl-L-leucine(out) => ADP + H(+) + L-alanyl-L-leucine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-874079", "l": "AIM2 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.1", "l": "\"dipeptidyl-peptidase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682377", "l": "LC3 de-lipidation by ATG4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018758", "l": "RHOH binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139842", "l": "Binding of Syk tyrosine kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102521", "l": "tRNA-4-demethylwyosine synthase activity", "d": ["Catalysis of the reaction: pyruvate + S-adenosyl-L-methionine + N1-methylguanine37 in tRNAPhe = L-methionine + 5'-deoxyadenosine + carbon dioxide + H2O + 4-demethylwyosine37 in tRNAPhe."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28709", "l": "Cd(2+)(out) => Cd(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392513", "l": "Rap1 signal termination by Rap1GAPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018759", "l": "methenyltetrahydromethanopterin cyclohydrolase activity", "d": ["Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928597", "l": "EPH:EFN dimers tetramerise (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21529", "l": "[phosphate](n) + H2O => [phosphate](n-1) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694281", "l": "Encapsidation of SARS coronavirus genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61798", "l": "AMP + L-tryptophyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-tryptophyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23581", "l": "prostaglandin H2 => prostaglandin I2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10579", "l": "CTP + H(+) + N-methylethanolamine phosphate <=> CDP-N-methylethanolamine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37286", "l": "H2O + L-alanyl-L-histidine <=> L-alanine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44992", "l": "(R)-carnitine + 2-methylbutanoyl-CoA = CoA + O-2-methylbutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607753", "l": "CARD9 oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2024100", "l": "GLCE epimerises GlcA to IdoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624798", "l": "LBR binds KPNB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48877", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O => L-seryl-[protein] + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28785", "l": "glycine + L-cysteine => H2O + L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43775", "l": "guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72315", "l": "glutathione(in) + leukotriene C4(out) = glutathione(out) + leukotriene C4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61095", "l": "H2O + N(2)-acetyl-L-citrulline <=> acetate + L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12030", "l": "H(+) + N-carbamoyl-L-aspartate => H2O + L-5-carboxymethylhydantoin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140983", "l": "calcium:manganese antiporter activity", "d": ["Catalysis of the reaction: Ca2+(in) + Mn2+(out) = Ca2+(out) + Mn2+(in)."]}, {"i": "RHEA:73059", "l": "Ca(2+)(in) + Mn(2+)(out) = Ca(2+)(out) + Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35045", "l": "N-(4-aminobenzoyl)-L-glutamate(out) => N-(4-aminobenzoyl)-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10094", "l": "a 2'-deoxyribonucleoside + phosphate => a 2'-deoxyribonucleoside 3'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050166", "l": "pantoate 4-dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-pantoate + NAD+ = (R)-4-dehydropantoate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28794", "l": "5,6-dihydrothymine + NAD(+) <=> H(+) + NADH + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44518", "l": "(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+) => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73475", "l": "D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0051912", "l": "CoB--CoM heterodisulfide reductase activity", "d": ["Catalysis of the reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12927", "l": "H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => D-erythrose 4-phosphate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40017", "l": "13-epi-manool + diphosphate => (+)-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917987", "l": "TFRC dimer binds 2xholoTF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.892466024748572", "identifiers": [{"i": "GO:0008171", "l": "O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16862", "l": "(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine => (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14127", "l": "1(F)-alpha-D-galactosylraffinose + sucrose => 2 raffinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696131", "l": "AOC1 deaminates Hist (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21019", "l": "H2O + L-asparagine <=> L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686430", "l": "MUS81 binds EME1, EME2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5622134", "l": "CRABP1 binds atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16480", "l": "NAD(+) + prostaglandin E1 <=> 15-oxoprostaglandin E1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37706", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683760", "l": "GalNAc is transferred onto 3a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58044", "l": "a long-chain fatty acyl-CoA + alpha,alpha-trehalose = 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA", "d": []}, {"i": "EC:2.3.1.279", "l": "\"long-chain-acyl-CoA--trehalose acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031733", "l": "CCR8 chemokine receptor binding", "d": ["Binding to a CCR8 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665998", "l": "MKL1 binds SRF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51117", "l": "guanosine(6) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174224", "l": "Dissociation of Cdc20 from APC/C complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17732", "l": "an acyl-CoA + cholesterol <=> a cholesterol ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37458", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174202", "l": "Degradation of multiubiquitinated Securin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022764", "l": "SGK1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714580", "l": "SLC6A3 binds DRIs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428609", "l": "Type I Na+-coupled phosphate co-transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53525", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429157", "l": "ABCC4 accumulation of dense granule contents (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875817", "l": "MET phosphorylates STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093331", "l": "Ras:GTP binds p120-RasGAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18900", "l": "3,3',5'-triiodo-L-thyronine + A + H(+) + iodide <=> AH2 + L-thyroxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53446", "l": "11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380574", "l": "Dopamine synaptic vesicle docking and priming (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40369", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2471621", "l": "Endostatin degradation by cathepsins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54750", "l": "AMP + diphosphate + L-firefly luciferyl-CoA => ATP + CoA + firefly L-luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703432", "l": "p-STAT5 dissociates from FLT3 fusion proteinsp- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218804", "l": "p38 MAPK activation by VEGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38742", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604247", "l": "JAG1 binds NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909729", "l": "Activation of JAK kinases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018707", "l": "1-phenanthrol methyltransferase activity", "d": ["Catalysis of the reaction: 1-phenanthrol + X-CH3 = X + 1-methoxyphenanthrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52314", "l": "11-dehydro-thromboxane B2 + H(+) + NADH => NAD(+) + thromboxane B2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34982", "l": "H(+)(in) <=> H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18241", "l": "D-lysine = (2R,5S)-2,5-diaminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68856", "l": "(2Z,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418456", "l": "cGMP is degraded by PDEs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71520", "l": "uridine(out) => uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868118", "l": "MAPK12 phosphorylates PTPN3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49798", "l": "a fatty acid + glycine => an N-(fatty acyl)-glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23421", "l": "alpha,alpha-trehalose 6-phosphate + H2O => alpha,alpha-trehalose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9698844", "l": "MLKL binds HSP90:CDC37 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55887", "l": "[aequorin] + 3 Ca(2+) <=> [aequorin]--dioxetanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14275", "l": "4-aminobutanal + AH2 + propane-1,3-diamine => A + H2O + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53661", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42153", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40890", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + octadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44472", "l": "1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2404134", "l": "RBP4:atROL binds TTR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38555", "l": "an all-trans-retinyl ester + H2O = a fatty acid + all-trans-retinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163666", "l": "Formation of ChREBP:MLX heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43742", "l": "AMP + diphosphate + hexanoyl-CoA => ATP + CoA + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67960", "l": "4-amino-L-phenylalanine + S-adenosyl-L-methionine = 4-methylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59439", "l": "4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein] <=> 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30595", "l": "4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.9", "l": "\"4-hydroxyphenylacetate 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66366", "l": "6-methyl-3,7-dioxodecanedioyl-CoA => (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38168", "l": "hexadecan-1-ol + hexadecanoyl-CoA => CoA + hexadecanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174202", "l": "Degradation of multiubiquitinated Securin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004784", "l": "superoxide dismutase activity", "d": ["Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70552", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-galactose => 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18038", "l": "agmatine + H2O => N-carbamoylputrescine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5444511", "l": "Formation of MSH2:MSH3 Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64382", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2 => 3 A + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37269", "l": "L-alanine + L-aspartate => H2O + L-alanyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14463", "l": "(25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP => (25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11143", "l": "alpha-D-mannose 1-phosphate <=> D-mannose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033932", "l": "1,3-alpha-L-fucosidase activity", "d": ["Catalysis of the hydrolysis of (1->3) linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1364044", "l": "PRLR:JAK2 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008526", "l": "phosphatidylinositol transfer activity", "d": ["Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055042", "l": "5-valerolactone hydrolase activity", "d": ["Catalysis of the reaction: 5-valerolactone + H2O = 5-hydroxyvalerate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72663", "l": "De novo formation of eIF2:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450348", "l": "Activated human JNKs migrate to nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45373", "l": "H2O + N-(9Z-octadecenoyl)-sphinganine => (9Z)-octadecenoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46809", "l": "[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine => [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204871", "l": "Interaction of Tie2 and Grb2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30377", "l": "(+)-thujopsene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18165", "l": "biphenyl + H(+) + NADH + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}, {"i": "EC:1.14.12.18", "l": "\"biphenyl 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67992", "l": "AH2 + trichloroethene = (Z)-1,2-dichloroethene + A + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31440", "l": "(2E,6E)-farnesyl diphosphate => alpha-longipinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034821", "l": "citronellol dehydrogenase activity", "d": ["Catalysis of the reaction: citronellol + NAD+ = citronellal + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46117", "l": "2-dehydro-3-deoxy-D-galactonate => D-glyceraldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26398", "l": "all-trans-zeaxanthin + 2 O2 => 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783880", "l": "PIPOX oxidises PPCA to P6C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205306", "l": "Interaction of SHP1 and KIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28064", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+) => alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264622", "l": "Cho is acetylated to AcCho by CHAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209754", "l": "Photolytic cleavage and thermal isomerization of 7-dehydroCHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635843", "l": "GLI translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46652", "l": "epitestosterone + H(+) + NADPH = 5beta-dihydroepitestosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17722", "l": "a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58087", "l": "1-(13Z-docosenoyl)-glycerol + H2O <=> (13Z)-docosenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68235", "l": "L-cysteine(in) + Na(+)(in) <=> L-cysteine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64873", "l": "D-ribulose 1-phosphate => dihydroxyacetone phosphate + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74250", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15379", "l": "(2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+) => (S)-4,5-dihydroxypentane-2,3-dione + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390597", "l": "Release Of ADP From Myosin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622668", "l": "FOXO3,(FOXO1) bind BBC3 gene first intron (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33010", "l": "(+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34234", "l": "5-nitrosalicylate + O2 <=> 4-nitro-6-oxohepta-2,4-dienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16488", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate <=> 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42383", "l": "2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O <=> 2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31996", "l": "(2E,6E)-farnesyl diphosphate => 7-epi-sesquithujene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10053", "l": "(R)-2-hydroxy-4-methylpentanoate + NAD(+) => 4-methyl-2-oxopentanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11233", "l": "3'-phosphoadenylyl sulfate + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.36", "l": "\"hyaluronoglucuronidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34056", "l": "festuclavine + NAD(+) => 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5685230", "l": "CHEK1 phosphorylates RAD51 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60810", "l": "CO2 + gibberellin A20 + H2O => gibberellin A19 + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24031", "l": "2-oxoglutarate + 4-(trimethylamino)butanoate + O2 <=> carnitine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23213", "l": "H2O + N-acetyl-beta-alanine => acetate + beta-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52808", "l": "adenosine in U6 snRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.346", "l": "\"U6 snRNA m(6)A methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33262", "l": "4-aminoimidazole + H(+) + 2 H2O <=> N-formimidoylglycine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60086", "l": "a 4alpha-methyl-3-oxosteroid + CO2 + NADH => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68840", "l": "(2Z,6E)-farnesyl diphosphate = (6R,7S)-2,2,6-trimethyl-10-methylenebicyclo[5.4.0]undec-1(11)-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45945", "l": "12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.3.-", "l": "\"Phosphotransferases with a nitrogenous group as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937814", "l": "RUNX3 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12692", "l": "2 mycothiol + NAD(+) <=> H(+) + mycothione + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0030558", "l": "RNA pseudouridylation guide activity", "d": ["Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10202", "l": "(2E)-2-butenoate + H(+) + NADH => butanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75198", "l": "2-dehydro-3-deoxy-D-arabinonate + NAD(+) <=> 5-hydroxy-2,4-dioxopentanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59474", "l": "Gp(2'-5')Ap(3') + H(+) => 2',3'-cGAMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30850", "l": "FAD + glutaryl-CoA + 2 H(+) <=> (2E)-butenoyl-CoA + CO2 + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21141", "l": "ATP + inosine => ADP + H(+) + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030785", "l": "[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5620975", "l": "MLKL binds PIPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31982", "l": "NADPH + O2 + trimethylamine <=> H2O + NADP(+) + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43587", "l": "H2O + iminoarginine <=> 5-guanidino-2-oxopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.2", "l": "\"dihydroorotate dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375140", "l": "CDO binds promyogenic cadherins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36356", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29875", "l": "H2O + sn-glycero-3-phospho-L-serine = H(+) + L-serine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75203", "l": "alpha,alpha-trehalose(out) + ATP + H2O = ADP + alpha,alpha-trehalose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55365", "l": "(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 6 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30749", "l": "(2E)-hexadecenoyl-CoA + FADH2 => FAD + H(+) + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "58.749688758303932", "identifiers": [{"i": "GO:0022804", "l": "active transmembrane transporter activity", "d": ["Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22977", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56732", "l": "4,4-dihydroxy-all-trans-beta-carotene = echinenone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16282", "l": "ATP + dihydrostreptomycin 6-phosphate => ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44377", "l": "a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) => a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74818", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102853", "l": "1-18:1-2-18:1-sn-glycerol-3-phosphocholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-18:1-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor <=> 1-18:2-2-18:1-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373705", "l": "Caspase cleavage of DCC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.535054500181104", "identifiers": [{"i": "GO:0140297", "l": "DNA-binding transcription factor binding", "d": ["Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25954", "l": "2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate => 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62426", "l": "3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA => (E)-caffeoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45507", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38678", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76085", "l": "(11R)-19-hydroxycarlactone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (11R)-carlactone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25637", "l": "H2O + NAD(+) + sulfoacetaldehyde = 2 H(+) + NADH + sulfoacetate", "d": []}, {"i": "EC:1.2.1.73", "l": "\"sulfoacetaldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73410", "l": "(S,S)-tartrate(in) + sulfate(out) <=> (S,S)-tartrate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68809", "l": "6-O-alpha-D-glucopyranosyl-D-fructose + H2O => alpha-D-glucose + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46449", "l": "2 L-tyrosyl-tRNA(Tyr) => cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391377", "l": "Luteinizing hormone receptor can bind LH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51136", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 = (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62519", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41836", "l": "H(+) + hexanoyl-[ACP] + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33621", "l": "AMP + diphosphate + tetradecanoyl-CoA => ATP + CoA + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350651", "l": "Caspase-mediated cleavage of MASK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158849", "l": "Phenol can form a sulfate conjugate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186747", "l": "Ubiquitination of SKI/SKIL by RNF111/SMURF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70492", "l": "GDP-beta-L-fucose + L-threonyl-[protein] => 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673756", "l": "Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805276", "l": "CDK5 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655404", "l": "SUMOylation of AURKA with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9658253", "l": "RAS:GTP binds PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205238", "l": "SHP2 interacts with p-KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61595", "l": "H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine <=> 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380949", "l": "AMPK is dephosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67134", "l": "(1S,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+) => 5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684140", "l": "ATM phosphorylates RBBP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0005152", "l": "interleukin-1 receptor antagonist activity", "d": ["Blocks the binding of interleukin-1 to the interleukin-1 receptor complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74071", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45293", "l": "2-glyceryl-prostaglandin G2 + AH2 => 2-glyceryl-prostaglandin H2 + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23198", "l": "3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine => 3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013435", "l": "RHOD auto-activates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46152", "l": "15-cis-phytoene + a plastoquinone = 15,9'-di-cis-phytofluene + a plastoquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34604", "l": "15-methylhexadecasphinganine + a fatty acyl-CoA => CoA + H(+) + N-acyl-15-methylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50992", "l": "thromboxane B2(out) = thromboxane B2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102372", "l": "alpha-amyrin 28-monooxygenase activity", "d": ["Catalysis of the reaction: alpha-amyrin + NADPH(4-) + O2 + H+ <=> uvaol + NADP(3-) + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18538", "l": "H2O + NAD(+) + salicylaldehyde => 2 H(+) + NADH + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54525", "l": "acetoacetate + H(+) + methylglyoxal => 3-hydroxyhexane-2,5-dione + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56686", "l": "2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine => dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12330", "l": "[(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate => [(1->3)-alpha-D-glucosyl](n) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004043", "l": "L-aminoadipate-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21522", "l": "CO2 + 2 Fe(II)-[cytochrome b1] + H(+) => 2 Fe(III)-[cytochrome b1] + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72589", "l": "(E)-sinapoyl-CoA + AMP + diphosphate => (E)-sinapate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33658", "l": "(9Z)-octadecenoate(out) <=> (9Z)-octadecenoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480378", "l": "Expression of Goosecoid (GSC) in the primitive streak (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797090", "l": "CCNK binds CDK12 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004525", "l": "ribonuclease III activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047647", "l": "alkylacetylglycerophosphatase activity", "d": ["Catalysis of the reaction: 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O = 2-acetyl-1-alkyl-sn-glycerol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693125", "l": "RHOF binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12906", "l": "alpha-D-mannose 1-phosphate + GDP + H(+) => GDP-alpha-D-mannose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3221982", "l": "BANP binds TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106425", "l": "3,4-dihydroxyphenylacetaldehyde synthase activity", "d": ["Catalysis of the reaction: L-dopa + O2 + H2O + H+ <=> 3,4-dihydroxyphenylacetaldehyde + CO2 + NH(4)+ + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49904", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 = (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451418", "l": "Pellino ubiquitinates IRAK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171122", "l": "LDL + LDLR => LDL:LDLR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68478", "l": "a fatty aldehyde + CO2 + H2O => a (2R)-2-hydroperoxy fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69531", "l": "chorismate + H2O + 2 L-glutamine <=> 4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637801", "l": "Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23715", "l": "NADP(+) + pregnan-21-ol <=> H(+) + NADPH + pregnan-21-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13451", "l": "2-oxoglutarate + H(+) + NADH => 2-hydroxyglutarate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097263", "l": "eoxin E4 synthase activity", "d": ["Catalysis of the reaction: eoxin D4 + H20 = eoxin E4 + glycine."]}, {"i": "REACT:R-HSA-2161868", "l": "EXD4 is converted to EXE4 by DPEP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68639", "l": "(2E)-geranyl diphosphate <=> diphosphate + sabinene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103037", "l": "L-glyceraldehyde 3-phosphate reductase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + NADP = H+ + L-glyceraldehyde 3-phosphate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913371", "l": "GM-CSF receptor alpha:GM-CSF binds Bc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381109", "l": "IRE1 binds IRE1 forming dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37814", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72243", "l": "catechol + S-adenosyl-L-methionine = guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50015", "l": "H(+) + NADPH + O2 + tert-butanol <=> 2-methylpropane-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68269", "l": "dUMP + formaldehyde + H(+) + NADPH => dTMP + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66277", "l": "tigogenin + UDP-alpha-D-glucose => H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003689", "l": "DNA clamp loader activity", "d": ["Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950766", "l": "IL27RA dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65163", "l": "benzoyl-CoA + hexan-2-ol <=> CoA + hexan-2-yl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52786", "l": "A + ergothioneine + H2O => 2-sulfenohercynine + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9724745", "l": "PLG(20-810) binds aprotinin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29462", "l": "beta-alanine(in) + H(+)(in) <=> beta-alanine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754130", "l": "CDK4 inhibitors bind CDK4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20996", "l": "(2Z,4E)-2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH4(+)", "d": []}, {"i": "EC:3.5.99.5", "l": "\"2-aminomuconate deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22217", "l": "(E)-caffeate + O2 => 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61374", "l": "4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate => 4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9626817", "l": "PKC phosphorylates NCF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389756", "l": "AKT interacts and phosphorylates Cot (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48209", "l": "H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69451", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> delta-cadinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36298", "l": "alpha-maltose 6'-phosphate + H2O <=> D-maltose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48293", "l": "ganglioside GM1 + GDP-beta-L-fucose => ganglioside Fuc-GM1 + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-447130", "l": "Interleukin-23 binds interleukin-23 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30325", "l": "beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2995334", "l": "COX15 transforms heme O to heme A (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139919", "l": "Translocation of BIM to mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71486", "l": "H2O + Met-enkephalin <=> L-phenylalanyl-L-methionine + L-tyrosylglycylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781840", "l": "ERCC6 binds stalled RNA Pol II (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31336", "l": "CTP + H(+) + Mo-molybdopterin => diphosphate + Mo-molybdopterin cytosine dinucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44603", "l": "a fatty acid + ATP + H(+) <=> a fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-217255", "l": "FMO1:FAD N-oxidises TAM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17444", "l": "2-oxoglutarate + L-cysteine <=> 2-oxo-3-sulfanylpropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032795", "l": "heterotrimeric G-protein binding", "d": ["Binding to a heterotrimeric G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52325", "l": "2 L-arginine + 4 O2 + 3 reduced [flavodoxin] => 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190261", "l": "FGFR3c binds to FGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55323", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140560", "l": "xylosyl alpha-1,3-xylosyltransferase activity", "d": ["Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine. The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)- beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF- like) domains."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645535", "l": "ALPK1 phosphorylates TIFA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5681987", "l": "LC3 is cleaved by ATG4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13703", "l": "CoA + O-acetyl-L-homoserine => acetyl-CoA + L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44019", "l": "2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) <=> 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28900", "l": "glycine(in) + H(+)(in) => glycine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.16", "l": "\"protein-serine/threonine phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19154", "l": "apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose => 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786650", "l": "DDHD1,2 hydrolyse PA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18060", "l": "O2 + Watasenia luciferin <=> CO2 + hnu + oxidized Watasenia luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16690", "l": "D-glucose 6-phosphate + H2O => D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193519", "l": "DHCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871226", "l": "RET binds GFRA1,GFRA2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17744", "l": "NAD(+) + shikimate <=> 3-dehydroshikimate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57958", "l": "dimethyl sulfone + H2O + NAD(+) => dimethyl sulfoxide + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17039", "l": "H(+) + indole-3-acetaldehyde + NADPH => indole-3-ethanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681514", "l": "TMPRSS2 binds TMPRSS2 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.58", "l": "\"heme oxygenase (biliverdin-IX-beta and delta-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015207", "l": "adenine transmembrane transporter activity", "d": ["Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22629", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate => (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56107", "l": "2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 <=> 4,4'-diaponeurosporenal + 2 A + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71467", "l": "H2O + substance P = L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38335", "l": "(20S)-ginsenoside Rb1 + 2 H2O = (20S)-ginsenoside Rg3 + 2 D-glucose", "d": []}, {"i": "EC:3.2.1.192", "l": "\"ginsenoside Rb1 beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4332363", "l": "Autophosphorylation and activation of CAMK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13077", "l": "an acyl phosphate + D-hexose = a carboxylate + D-hexose phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.61", "l": "\"acyl-phosphate--hexose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430347", "l": "MigFilin associates with Filamin and F-actin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48136", "l": "ganglioside GM3 + H2O = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54303", "l": "n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate <=> n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855111", "l": "VLDLR binds PCSK9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74425", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56690", "l": "(2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187303", "l": "SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48710", "l": "a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58721", "l": "(S)-nicotine + NADPH + O2 => H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380586", "l": "loading of Serotonin in synaptic vesicles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14937", "l": "all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65249", "l": "AH2 + 5 H(+) + 5 malonyl-CoA => 6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72266", "l": "chloride(out) + oxalate(in) <=> chloride(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2562526", "l": "PLK1 phosphorylates OPTN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449829", "l": "IL11 binds IL11RA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32739", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52878", "l": "16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16beta,17beta-estriol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654422", "l": "Activated FGFR4 binds FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42541", "l": "uridine(13) in tRNA => pseudouridine(13) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000102", "l": "L-methionine secondary active transmembrane transporter activity", "d": ["Enables the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247844", "l": "WNT ligands traffic to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34144", "l": "cannabinerolate + O2 => Delta(9)-tetrahydrocannabinolate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663105", "l": "p-BMAL1:p-CLOCK,NPAS2 binds BHLHE41 (DEC2) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44481", "l": "3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15129", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.99", "l": "\"(S)-limonene 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42059", "l": "13-cis-retinol + NAD(+) <=> 13-cis-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19709", "l": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA", "d": []}, {"i": "EC:2.3.1.51", "l": "\"1-acylglycerol-3-phosphate O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75254", "l": "carminate + O2 <=> 3'-dehydrocarminate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0045290", "l": "D-arabinose 1-dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61588", "l": "amicoumacin A + ATP = ADP + amicoumacin A 2-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.230", "l": "\"amicoumacin kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050206", "l": "oximinotransferase activity", "d": ["Catalysis of the reaction: 2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32679", "l": "(2E)-geranyl diphosphate + H2O = (2E)-geraniol + diphosphate", "d": []}, {"i": "EC:3.1.7.11", "l": "\"geranyl diphosphate diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60428", "l": "(indol-3-yl)acetyl-L-aspartate + H2O = (indol-3-yl)acetate + L-aspartate", "d": []}, {"i": "EC:3.5.1.134", "l": "\"(indol-3-yl)acetyl-L-aspartate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082391", "l": "Trimerization of HSF1 in the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201634", "l": "Caspase-mediated cleavage of FADK 1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10711", "l": "alpha-D-glucose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617815", "l": "BBSome binds RAB3IP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50355", "l": "3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH <=> 3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820538", "l": "MSGN1 binds the TBX6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27783", "l": "4-hydroxybenzoate + all-trans-octaprenyl diphosphate => 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70990", "l": "beta-alanine(out) + n H(+)(in) <=> beta-alanine(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109700", "l": "AKT2 binds PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39010", "l": "a cholesterol ester(in) <=> a cholesterol ester(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50441", "l": "prostaglandin H1 => prostaglandin D1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849055", "l": "PTK6 binds ARHGAP35 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50440", "l": "prostaglandin H1 = prostaglandin D1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165680", "l": "Formation of active mTORC1 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39336", "l": "3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35150", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) <=> (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0033695", "l": "oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule."]}, {"i": "EC:1.17.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015155", "l": "lactose transmembrane transporter activity", "d": ["Enables the transfer of lactose from one side of a membrane to the other. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28507", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP => 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69785", "l": "2-(2-aminophenyl)succinyl-CoA + succinate => (2-aminophenyl)succinate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60741", "l": "(S)-(-)-citronellal + H2O + NADP(+) => (S)-(-)-citronellate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0000026", "l": "alpha-1,2-mannosyltransferase activity", "d": ["Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1031716", "l": "Expression of IFNG-stimulated genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65098", "l": "a 1-hexadecanoyl-2-acylglycerol + CoA => a 2-acylglycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10588", "l": "4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH = 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63418", "l": "2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O => 2,6-dichlorohydroquinone + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58952", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose = (20S)-ginsenoside Rh1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44384", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050552", "l": "(4S)-limonene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = (4S)-limonene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106423", "l": "tubulin-tyrosine carboxypeptidase", "d": ["Catalysis of the reaction: C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5695964", "l": "ABHD14B hydrolyses PNPB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39340", "l": "(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13846", "l": "dihydroxyfumarate + H(+) => 2-hydroxy-3-oxopropanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619449", "l": "PPM1F dephosphorylates p-T286-CaMKII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38770", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445084", "l": "Phosphorylation of L1 by SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51678", "l": "[protein]-dithiol + 2 AH2 + H(+) + sulfite => [protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800298", "l": "HGF dimer binds MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357445", "l": "PAK1-3 dimer disassociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35874", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75212", "l": "Cu(+)(out) => Cu(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785594", "l": "FANCD2 binds FANCI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39877", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33570", "l": "A + ethanol <=> acetaldehyde + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25556", "l": "9alpha-copalyl diphosphate = diphosphate + stemod-13(17)-ene", "d": []}, {"i": "EC:4.2.3.34", "l": "\"stemod-13(17)-ene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404134", "l": "RBP4:atROL binds TTR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37220", "l": "A + D-valine + H2O => 3-methyl-2-oxobutanoate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420233", "l": "VIP receptors bind VIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794346", "l": "NRXNs bind NLGNs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56469", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 => (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27737", "l": "4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O <=> 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14466", "l": "H2O + L-histidinol phosphate => L-histidinol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201669", "l": "Beta-catenin translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57527", "l": "a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + H2O <=> a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40235", "l": "coenzyme B + coenzyme M + fumarate = coenzyme M-coenzyme B heterodisulfide + succinate", "d": []}, {"i": "EC:1.3.4.1", "l": "\"fumarate reductase (CoM/CoB)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12080", "l": "acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA", "d": []}, {"i": "EC:2.3.1.180", "l": "\"beta-ketoacyl-[acyl-carrier-protein] synthase III\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050103", "l": "dextrin dextranase activity", "d": ["Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + 1,6-alpha-D-glucosyl(m) = 1,4-alpha-D-glucosyl(n-1) + 1,6-alpha-D-glucosyl(m+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027274", "l": "EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353298", "l": "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-169827", "l": "DPDK1 phosphorylates and activates DS6K (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73307", "l": "H(+)(in) + L-aspartate(out) + phosphate(in) = H(+)(out) + L-aspartate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34175", "l": "2-hydroxybenzoyl-CoA + malonyl-CoA = 4-hydroxycoumarin + CO2 + 2 CoA", "d": []}, {"i": "EC:2.3.1.208", "l": "\"4-hydroxycoumarin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854466", "l": "VLDLR binds RELN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626681", "l": "Recruitment of transition zone proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16072", "l": "cytidine + H(+) + H2O <=> NH4(+) + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48041", "l": "globoside Gb4Cer + H2O => globoside Gb3Cer + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68019", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H2O <=> (2E,6E,10E)-geranylgeraniol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102559", "l": "protein-(glutamine-N5) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a [release factor]-L-glutamine = S-adenosyl-L-homocysteine + H+ + a [release factor]-N5-methyl-L-glutamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798528", "l": "S100A8:S100A9 binds Mn2+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11308", "l": "acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl-CoA + phosphate", "d": []}, {"i": "EC:6.4.1.2", "l": "\"acetyl-CoA carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.34", "l": "\"lipoprotein lipase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67147", "l": "2-oxoglutarate + jasmonate + O2 <=> (1R,2R)-12-hydroxyjasmonate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.10", "l": "\"adenosylcobinamide-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66036", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44443", "l": "a 1,3-diacylglycerol + a 1-acylglycerol <=> a triacylglycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16896", "l": "pyridine + S-adenosyl-L-methionine <=> N-methylpyridinium + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864690", "l": "TFAP2A,(TFAP2B) homodimers bind the KIT gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72490", "l": "citrate(out) + phosphoenolpyruvate(in) <=> citrate(in) + phosphoenolpyruvate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51926", "l": "A + beta-dihydromenaquinone-9 => AH2 + menaquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62789", "l": "2 fonsecin B + H(+) + NADPH + O2 => aurasperone B + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483186", "l": "PC is converted to PS by PTDSS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0098879", "l": "structural constituent of postsynaptic specialization", "d": ["The action of a molecule that contributes to the structural integrity of a postsynaptic specialization."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74440", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) => a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13213", "l": "H2O + NADP(+) + succinate semialdehyde = 2 H(+) + NADPH + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71121", "l": "3-hydroxyhispidin + H2O + NADP(+) => H(+) + hispidin + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391933", "l": "EP3 receptor can bind PGE2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12204", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749647", "l": "CES2 hydrolyzes ASA- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-877281", "l": "PIAS1 binds p-STAT1 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684052", "l": "PIAS4 SUMOylates MDC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660660", "l": "p300 acetylates RELA subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017129", "l": "triglyceride binding", "d": ["Binding to a triester of glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015104", "l": "antimonite transmembrane transporter activity", "d": ["Enables the transfer of antimonite from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400027", "l": "Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35463", "l": "lathosterol + NAD(+) = 5alpha-cholest-7-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.652932776586212", "identifiers": [{"i": "GO:0008649", "l": "rRNA methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39316", "l": "(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA => (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67284", "l": "(2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione = (1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5662466", "l": "XYLB phosphorylates D-xylulose (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51011", "l": "2 Fe(III)-[cytochrome cL] + methanol <=> 2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18599", "l": "NADH + 2 oxidized [rubredoxin] => H(+) + NAD(+) + 2 reduced [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209075", "l": "Destabilisation and degradation of AXN in the 'destruction complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.337", "l": "\"L-2-hydroxycarboxylate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70313", "l": "cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034793", "l": "cyclopropanecarboxylate-CoA ligase activity", "d": ["Catalysis of the reaction: cyclopropanecarboxylate + CoASH = cyclopropanecarboxyl-CoA + OH-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450348", "l": "Activated human JNKs migrate to nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33529", "l": "CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate => acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72590", "l": "(E)-sinapate + ATP + CoA <=> (E)-sinapoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47959", "l": "3-maleylpyruvate + H2O <=> H(+) + maleate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13858", "l": "a dolichyl beta-D-glucosyl phosphate + H2O => a dolichyl phosphate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.251", "l": "\"lipid IVA palmitoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972979", "l": "POU5F1 (OCT4), NANOG bind the CDX2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43104", "l": "AH2 + an N-acyleicosasphinganine + O2 = A + an N-acyleicosasphing-4-enine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41059", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004108", "l": "citrate (Si)-synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140751", "l": "histone octamer slider activity", "d": ["A chromatin remodeler activity that slides core histone octamers along chromosomal DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191072", "l": "Synthesis of Cx43 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174967", "l": "NAT2 acetylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12209", "l": "4-methylumbelliferyl acetate + H2O => 4-methylumbelliferone + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20059", "l": "CO2 + NH4(+) + sarcosine => 2 H(+) + H2O + N-carbamoylsarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159868", "l": "Furin cleaves pro-factor VII to factor VII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66946", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102050", "l": "indole-3-acetyl-tyrosine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-tyrosine + ATP(4-) <=> H+ + indole-3-acetyl-tyrosine + AMP(2-) + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009034", "l": "tryptophanase activity", "d": ["Catalysis of the reaction: L-tryptophan + H2O = indole + NH4 + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004844", "l": "uracil DNA N-glycosylase activity", "d": ["Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29665", "l": "H(+)(out) + xanthine(out) => H(+)(in) + xanthine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.1.14", "l": "\"nocardicin-A epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40868", "l": "(9E)-octadecenoyl-CoA + FAD + H(+) => (2E,9E)-octadecadienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218811", "l": "DOCK180:ELMO binds CRK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873918", "l": "Transphosphorylation of JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209828", "l": "Tryptophan is hydroxylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804100", "l": "HMGB1 binds LPS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210294", "l": "Interaction of PECAM-1 and SHP-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086085", "l": "cell adhesive protein binding involved in SA cardiac muscle cell-atrial cardiac muscle cell communication", "d": ["Binding to a protein or protein complex that results in the connection of an SA cardiomyocyte with an atrial cardiomyocyte and contributes to the communication between the two cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45699", "l": "N-(acetyl)-sphing-4-enine-1-phosphate(in) <=> N-(acetyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047140", "l": "glutathione-CoA-glutathione transhydrogenase activity", "d": ["Catalysis of the reaction: oxidized glutathione + CoA = reduced glutathione + CoA-glutathione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604763", "l": "Autocatalytic activation of MMP7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37698", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA <=> 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68818", "l": "(E)-alpha-bisabolene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004614", "l": "phosphoglucomutase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47220", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12276", "l": "3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.4", "l": "\"isovaleryl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432295", "l": "GPVI binds Fyn and Lyn (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47534", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => chenodeoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55943", "l": "all-trans-3,4-didehydroretinol + NAD(+) <=> all-trans-3,4-didehydroretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31647", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate", "d": []}, {"i": "EC:3.2.1.180", "l": "\"unsaturated chondroitin disaccharide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75842", "l": "H(+)(in) + K(+)(in) + Na(+)(out) + serotonin(out) <=> H(+)(out) + K(+)(out) + Na(+)(in) + serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74651", "l": "CTP + N-acetyl-D-glucosamine = CDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27354", "l": "4'-demethylrebeccamycin + S-adenosyl-L-methionine => H(+) + rebeccamycin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34335", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (22R)-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37199", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26088", "l": "(4S)-limonene + H(+) + NADPH + O2 <=> H2O + limonene 1,2-epoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8980691", "l": "RHOA GEFs activate RHOA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009374", "l": "biotin binding", "d": ["Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375138", "l": "CDO binds BOC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944223", "l": "Association of procollagen type V (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453200", "l": "SYK autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23751", "l": "ATP + GTP <=> diphosphate + pppGp(2'-5')A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047989", "l": "hydroxybutyrate-dimer hydrolase activity", "d": ["Catalysis of the reaction: (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate + H2O = 2 (R)-3-hydroxybutanoate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683583", "l": "ATG10:ATG12:ATG7 dimer dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13890", "l": "FAD + H2O => AMP + FMN + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663363", "l": "Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102435", "l": "myricetin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: myricetin(1-) + S-adenosyl-L-methionine <=> 7-O-methylmyricetin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52546", "l": "2-dehydro-D-erythronate + H(+) + NADH => D-erythronate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73246", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether <=> cirsimaritin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63350", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate => ATP + L-amino acyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41276", "l": "H2O + N-eicosanoyl-sphing-4-enine => eicosanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39357", "l": "(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+) => (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46464", "l": "(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050330", "l": "theanine hydrolase activity", "d": ["Catalysis of the reaction: N(5)-ethyl-L-glutamine + H2O = L-glutamate + ethylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647978", "l": "pro-RAS proteins are farnesylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68031", "l": "6,8-dihydroxypurine + H2O + O2 <=> H2O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952069", "l": "HDAC4 deacetylates RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042970", "l": "homoserine transmembrane transporter activity", "d": ["Enables the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32093", "l": "dTDP + erythromycin D + H(+) => 3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867041", "l": "EGFR phosphorylates EPS15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690494", "l": "RHOB translocates to the endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54439", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 <=> a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23260", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55666", "l": "2 A + canthaxanthin + 3 H2O => 2 AH2 + echinenone + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27587", "l": "L-tryptophan + pyruvate => indole-3-pyruvate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0099511", "l": "voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels", "d": ["Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21216", "l": "ATP + D-ribose 5-phosphate = ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.18", "l": "\"phosphoribokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008753", "l": "NADPH dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73498", "l": "an 8-hydroxyflavone + S-adenosyl-L-methionine <=> an 8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19557", "l": "AH2 + O2 + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O", "d": []}, {"i": "EC:1.14.99.24", "l": "\"steroid 9alpha-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46247", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66631", "l": "(2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2 <=> (2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13459", "l": "(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2 => (R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51158", "l": "AMP + diphosphate + L-glutamyl-tRNA(Gln) => ATP + L-glutamate + tRNA(Glu)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008837", "l": "diaminopimelate epimerase activity", "d": ["Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696275", "l": "RND2 binds GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12191", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) <=> (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53072", "l": "2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106433", "l": "O6-methyl-dGTP hydrolase activity", "d": ["Catalysis of the reaction O6-methyl-dGTP + H2O = O6-methyl-dGMP + diphosphate + H+."]}, {"i": "RHEA:67600", "l": "H2O + O(6)-methyl-dGTP = diphosphate + H(+) + O(6)-methyl-dGMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61399", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427514", "l": "eNoSC deacetylates histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59223", "l": "(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31774", "l": "an all-trans-retinyl ester + H2O <=> 11-cis-retinol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20288", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate <=> alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661517", "l": "LUBAC binds OTULIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016218", "l": "polyketide synthase activity", "d": ["Catalysis of a multistep reaction that produce polyketides through decarboxylative condensation of carboxylic acids. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48147", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine <=> ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.1", "l": "\"leucyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39532", "l": "3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1369052", "l": "ABCAs mediate lipid influx (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429441", "l": "SYK activation by SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54184", "l": "an N-acyl-aromatic L-alpha-amino acid + H2O = a carboxylate + an aromatic L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12937", "l": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": []}, {"i": "EC:2.3.1.23", "l": "\"1-acylglycerophosphocholine O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42114", "l": "H(+) + NADPH + progesterone => (20S)-hydroxypregn-4-en-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74712", "l": "Dissociation of IRS-P from insulin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11560", "l": "(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) = catechol + CO2 + NADH", "d": []}, {"i": "EC:1.3.1.25", "l": "\"1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56773", "l": "2 AH2 + all-trans-adonixanthin + 2 O2 => 2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12253", "l": "4-O-(beta-D-glucosyl)-trans-coniferol + H2O => (E)-coniferol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14512", "l": "2-oxoglutarate + mugineate + O2 <=> 3-epihydroxymugineate + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654510", "l": "FGFRL1 binds SPRED1/2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0106228", "l": "peptide glutaryltransferase activity", "d": ["Catalysis of the reaction: glutaryl-CoA + L-lysyl-[protein] = CoA + H+ + N6-glutaryl-L-lysyl-[protein]."]}, {"i": "RHEA:18009", "l": "glutaryl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38515", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444523", "l": "CXCR5 binds CXCL13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396402", "l": "NOTCH1 PEST domain mutants bind promoters of HEY genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981093", "l": "IL12 bound to IL12R internalises (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862771", "l": "PLA2G2A binds bacterial phospholipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13619", "l": "5-(methylsulfanyl)-D-ribose + adenine => H2O + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15171", "l": "L-glutamate + succinate => H2O + N-succinyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48941", "l": "an L-aminoacyl-L-amino acid + H2O => 2 an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48755", "l": "2-oxoglutarate + O2 + validamycin A <=> CO2 + H(+) + succinate + validamycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75409", "l": "cortalcerone + H2O => 2-dehydro-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015100", "l": "vanadium ion transmembrane transporter activity", "d": ["Enables the transfer of vanadium (V) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008508", "l": "bile acid:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43059", "l": "5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH <=> 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350901", "l": "Iodide is organified (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30218", "l": "a menaquinol + 2 nitric oxide <=> a menaquinone + H2O + nitrous oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33679", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40629", "l": "2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate => H2O + trihexadecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16022", "l": "oxaloacetate => enol-oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112395", "l": "Abortive termination of elongation after arrest (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70264", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937792", "l": "RUNX3 binds SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.45", "l": "\"atrolysin F\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937989", "l": "RUNX1 binds PRC1 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39822", "l": "docosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 2-hydroxydocosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43583", "l": "A + D-arginine <=> AH2 + iminoarginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785762", "l": "IL13RA1 binds TYK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592251", "l": "Expression of mTERF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32154", "l": "9alpha-copalyl diphosphate <=> (12E)-9alpha-labda-8(17),12,14-triene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726949", "l": "PTGIR binds PTGIR agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46587", "l": "1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177937", "l": "Phosphorylation of EGFR by SRC kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.47", "l": "\"alternative-complement-pathway C3/C5 convertase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40761", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38471", "l": "L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.44", "l": "\"L-histidine N(alpha)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047547", "l": "2-methylcitrate dehydratase activity", "d": ["Catalysis of the reaction: (2S,3S)-2-methylcitrate = cis-2-methylaconitate + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050514", "l": "homospermidine synthase (spermidine-specific) activity", "d": ["Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29627", "l": "alpha-maltohexaose + beta-maltose = alpha-maltoheptaose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63504", "l": "daunorubicin + H(+) + NADPH = 13-dihydrodaunorubicin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28838", "l": "citrate(out) + succinate(in) <=> citrate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47946", "l": "(2E)-geranyl phosphate + H(+) + phosphate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31767", "l": "2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine = L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}, {"i": "EC:2.6.1.92", "l": "\"UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46167", "l": "a quinone + H(+) + NADPH <=> a quinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22304", "l": "a ubiquinone + keto-D-fructose = 5-dehydro-D-fructose + a ubiquinol", "d": []}, {"i": "EC:1.1.5.14", "l": "\"fructose 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51064", "l": "3'-phosphoadenylyl sulfate + lithocholate = adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16372", "l": "(R)-lactate + NAD(+) <=> H(+) + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20296", "l": "3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) <=> 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21995", "l": "acetyl-CoA + L-lysyl-[histone] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9728150", "l": "SLC5A2 binds gliflozins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103066", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity", "d": ["Catalysis of the reaction: 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 4alpha-methyl-5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23120", "l": "a dipeptide(out) + ATP + H2O = a dipeptide(in) + ADP + H(+) + phosphate", "d": []}, {"i": "EC:7.4.2.9", "l": "\"ABC-type dipeptide transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213192", "l": "Hemidesmosome formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52313", "l": "NAD(+) + thromboxane B2 => 11-dehydro-thromboxane B2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61795", "l": "ATP + L-tryptophan <=> diphosphate + L-tryptophyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44036", "l": "12,13-epoxy-(9Z)-octadecenoate + H2O = 12,13-dihydroxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11231", "l": "(2S)-flavan-4-ol + NADP(+) <=> (2S)-flavanone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12768", "l": "CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate <=> acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12687", "l": "H(+) + mycothione + NADPH => 2 mycothiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55158", "l": "a quinol + S-sulfanylglutathione => a quinone + glutathione + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30957", "l": "7,7',9,9'-tetra-cis-lycopene + 2 a quinol => 9,9'-di-cis-zeta-carotene + 2 a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43225", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130619", "l": "TGN-lysosomal vesicle coat assembly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362485", "l": "GHBP binds GH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0032052", "l": "bile acid binding", "d": ["Binding to a bile acid, a steroid carboxylic acids occurring in bile."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090439", "l": "tetraketide alpha-pyrone synthase activity", "d": ["Catalyzes the reaction: a hydroxyacyl-CoA + 3 malonyl-CoA + 2 H+ = a hydroxylated tetraketide alpha-pyrone + 3 CO2 + 4 coenzyme A ."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29118", "l": "H(+) + menaquinone-8 + NADPH <=> menaquinol-8 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33865", "l": "fumarate + menaquinol-7 => menaquinone-7 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73712", "l": "ATP(in) + UTP(out) => ATP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62421", "l": "a (R)-2-hydroxy fatty acid + O2 => a fatty acid + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60469", "l": "3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043338", "l": "CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity", "d": ["Catalysis of the reaction: CTP + 2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate = CDP-2,3-di-O-geranylgeranyl-sn-glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174157", "l": "Degradation of multiubiquitinated Cyclin B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34629", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679044", "l": "FKBP1A binds sirolimus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2995376", "l": "BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28737", "l": "H(+)(out) + spermidine(in) => H(+)(in) + spermidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37639", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190263", "l": "FGFR3b binds to FGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47721", "l": "H(+) + H2O + isoguanine => NH4(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419049", "l": "ROCK activation by RHO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112436", "l": "Formation of Elongin complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17310", "l": "a phenyl acetate + H2O => a phenol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11809", "l": "bergaptol + S-adenosyl-L-methionine => bergapten + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23629", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65087", "l": "asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72621", "l": "Ribosomal scanning  (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62821", "l": "1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38092", "l": "delta-tocotrienol + S-adenosyl-L-methionine => beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25822", "l": "4-aminobutanal + H2O2 + propane-1,3-diamine => H2O + O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132096", "l": "Formation of C4b:factor B complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983142", "l": "Formation of peptide loading complex (PLC) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46955", "l": "2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40817", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.5", "l": "\"exodeoxyribonuclease V\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030110", "l": "HLA-C specific inhibitory MHC class I receptor activity", "d": ["Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871226", "l": "RET binds GFRA1,GFRA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168859", "l": "Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432148", "l": "Fgr may phosphorylate p38 MAPK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62257", "l": "Cd(2+)(out) + 2 hydrogencarbonate(out) => Cd(2+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42055", "l": "9-cis-retinol + NAD(+) <=> 9-cis-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602454", "l": "proMMP9 binds TIMP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653886", "l": "B4GALT1 binds LALBA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58111", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] <=> acetate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53257", "l": "lathosterol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015133", "l": "uronic acid transmembrane transporter activity", "d": ["Enables the transfer of uronic acid from one side of a membrane to the other. Uronic acids are any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58125", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27503", "l": "3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine => 3',5'-di-O-methyltricetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67125", "l": "a hydroperoxide + L-cysteinyl-[protein] => an alcohol + S-hydroxy-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46544", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.17", "l": "\"sphingolipid 4-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963851", "l": "VD3 dissociates from GC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70965", "l": "3-phenylpyruvate + H2O2 + NH4(+) => D-phenylalanine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36899", "l": "guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.228", "l": "\"tRNA (guanine(37)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63186", "l": "H(+) + NAD(+) + 2 superoxide => NADH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937613", "l": "CRHBP binds CRH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373738", "l": "Neurofascin interacts with syntenin-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671737", "l": "p-T774-PKN1 binds CDC25C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051749", "l": "indole acetic acid carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: indole acetic acid + S-adenosyl-methionine = methyl indole acetic acid ester + S-adenosyl-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16869", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}, {"i": "EC:1.13.11.33", "l": "\"arachidonate 15-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.18.6", "l": "\"4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77077", "l": "Capping complex formation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997237", "l": "SH2B proteins bind JAK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52452", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate = 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985943", "l": "p-Y701-STAT1 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42181", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265177", "l": "Exocyst complex formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53856", "l": "NADP(+) + ursocholate = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64949", "l": "dCTP + H2O => dCDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29717", "l": "FMN + glycolaldehyde + 2 H(+) + H2O + sulfite => 2-hydroxyethane-1-sulfonate + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3266557", "l": "Factor I cleaves iC3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55209", "l": "(4R)-hydroxysphinganine 1-phosphate => (2R)-hydroxyhexadecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18984", "l": "(R)-pantolactone + NADP(+) <=> 2-dehydropantolactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31859", "l": "(S)-2,3-epoxysqualene = glutinol", "d": []}, {"i": "EC:5.4.99.49", "l": "\"glutinol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42766", "l": "CO2 + reduced coenzyme F420-(gamma-L-Glu)(n) => formate + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66434", "l": "H(+)(in) + L-galactose(in) => H(+)(out) + L-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50714", "l": "7-chlorotetracycline + FAD + H(+) + 2 H2O => chloride + FADH2 + O2 + tetracycline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28200", "l": "acetophenone + H(+) + NADH => (S)-1-phenylethanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4615910", "l": "SUMOylation of PCNA with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24038", "l": "a ribonucleoside 5'-diphosphate + ADP => a ribonucleoside 5'-phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66905", "l": "A + cannabinerolate => AH2 + cannabichromenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17672", "l": "3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62381", "l": "carbaryl + H(+) + H2O => 1-naphthol + CO2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042286", "l": "glutamate-1-semialdehyde 2,1-aminomutase activity", "d": ["Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938371", "l": "RUNX2:CBFB binds the LGALS3 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709406", "l": "CO binds to Cytochrome c oxidase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60336", "l": "N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014296", "l": "RAC2 GEFs activate RAC2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67160", "l": "chloride + FADH2 + melleolide F + O2 = 6'-chloromelleolide F + FAD + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68954", "l": "Mcm2-7 is phosphorylated by DDK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762246", "l": "ANGPTL4 binds CDH11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41017", "l": "1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74536", "l": "2 AH2 + 2 archaetidylglycerol + 4 S-adenosyl-L-methionine => 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether glycerophospholipid + 4 H(+) + 4 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69945", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + typhasterol => 6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-912734", "l": "CBL:CRKL binds RAPGEF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36023", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69437", "l": "7-oxopregnenolone + H(+) + NADPH => 7beta-hydroxypregnenolone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607733", "l": "BCL10 binds CARD9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5684096", "l": "CDK2 phosphorylates RBBP8 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12719", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43103", "l": "S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) <=> 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22841", "l": "D-glutamine + H2O => D-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983078", "l": "p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785181", "l": "LMF1,2 bind LIPC dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855220", "l": "(PP)2-IP4 transports from the nucleus to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52979", "l": "a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.80", "l": "\"streptogrisin A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73949", "l": "(4E,6E)-allo-ocimene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17686", "l": "H(+) + uracil 5-carboxylate => CO2 + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58392", "l": "4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32789", "l": "ADP + H(+) + L-ectoine(in) + phosphate => ATP + H2O + L-ectoine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848436", "l": "PTK6 phosphorylates CDKN1B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9613497", "l": "Unwinding DNA for the nascent transcript (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604703", "l": "RUNX1 binds NOTCH4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14553", "l": "(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C", "d": []}, {"i": "EC:2.6.1.74", "l": "\"cephalosporin-C transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858482", "l": "DVL is recruited to the receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75369", "l": "cytidine(out) => cytidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52460", "l": "17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36266", "l": "hydroxyurea + O-acetyl-L-serine <=> acetate + H(+) + O-ureido-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45956", "l": "(9Z)-octadecenoyl-CoA(in) = (9Z)-octadecenoyl-CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27731", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) => beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051065", "l": "CTP reductase activity", "d": ["Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74258", "l": "H2O + L-homoseryl-tRNA(Ser) <=> H(+) + L-homoserine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17063", "l": "catechol + H2O + NADP(+) => H(+) + NADPH + O2 + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202129", "l": "HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70338", "l": "2-carboxy-L-lyxonolactone + H2O <=> 2-carboxy-L-lyxonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71149", "l": "4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one => 3-hydroxyhispidin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2514790", "l": "Elastin degradation by MMP14 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12990", "l": "a dolichyl beta-D-mannosyl phosphate + H2O => a dolichyl phosphate + D-mannose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004146", "l": "dihydrofolate reductase activity", "d": ["Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2471842", "l": "Collagen type XXV ectomain shedding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42030", "l": "7-oxolithocholate + H(+) + NADH => NAD(+) + ursodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19144", "l": "all-trans-retinol <=> 11-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220611", "l": "Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18653", "l": "barbiturate + H2O = 3-oxo-3-ureidopropanoate", "d": []}, {"i": "EC:3.5.2.1", "l": "\"barbiturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001856", "l": "complement component C5a binding", "d": ["Binding to a C5a product of the complement cascade."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15620", "l": "Fe(3+) + Fe(II)-[cytochrome c] <=> Fe(2+) + Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31691", "l": "(9Z,12Z)-octadecadienoate + O2 = (9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18635", "l": "2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate => 2 ATP + H2O + hydrogencarbonate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57752", "l": "2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27703", "l": "aldehydo-D-galacturonate => keto-D-tagaturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30677", "l": "H2O + squalene => tetrahymanol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016419", "l": "S-malonyltransferase activity", "d": ["Catalysis of the transfer of a malonyl group to a sulfur atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749647", "l": "CES2 hydrolyzes ASA- (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66454", "l": "1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16589", "l": "A + sucrose = 3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2", "d": []}, {"i": "EC:1.1.99.13", "l": "\"glucoside 3-dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74718", "l": "Internalisation of the insulin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.126", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047548", "l": "2-methyleneglutarate mutase activity", "d": ["Catalysis of the reaction: 2-methyleneglutarate = 2-methylene-3-methylsuccinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61228", "l": "H2O + L-histidine + O2 = 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26143", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O <=> 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672168", "l": "Ligand-independent dimerization of PDGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10079", "l": "H2O + lactose <=> beta-D-galactose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38508", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5444516", "l": "Formation of MSH2:MSH6 Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447219", "l": "IL17RA and IL17RB bind IL25 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28196", "l": "3-sulfopyruvate + H(+) + NADH => (2S)-3-sulfolactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45316", "l": "H(+) + NADPH + prostaglandin D2 = 11beta-prostaglandin F2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21730", "l": "GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH => GDP-alpha-D-mannose + H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73397", "l": "L-aspartate(out) + sulfate(in) => L-aspartate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49202", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate => D-mannose 6-phosphate + H2O + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45488", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2514790", "l": "Elastin degradation by MMP14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140941", "l": "histone H4K20me methyltransferase activity", "d": ["Catalysis of the reaction: N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H+ + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the monomethlyated lysine residue at position 20 of histone H4, producing H4K20me2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20165", "l": "H2O + N(5)-acyl-L-ornithine ester = an alcohol + H(+) + N(5)-acyl-L-ornithine", "d": []}, {"i": "EC:3.1.1.48", "l": "\"fusarinine-C ornithinesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592240", "l": "Formation of NRF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47062", "l": "4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36348", "l": "N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine => 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863471", "l": "LDLR is bound by DAB2 and ARH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31525", "l": "3 CO2 + ethene + H2O => 2-oxoglutarate + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9671145", "l": "DKC1 binds SHQ1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015164", "l": "glucuronoside transmembrane transporter activity", "d": ["Enables the transfer of a glucuronosides from one side of a membrane to the other. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.136", "l": "\"2-acylphloroglucinol 4-prenyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-481010", "l": "Surface deployment of platelet dense granule membrane components (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75862", "l": "all-trans-4-hydroxy-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-4-oxo-13,14-dihydroretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30675", "l": "tetrahymanol = H2O + squalene", "d": []}, {"i": "EC:4.2.1.123", "l": "\"tetrahymanol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31407", "l": "all-trans-4,4'-diaponeurosporene + FAD + H(+) = all-trans-4,4'-diapolycopene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657836", "l": "NR1H2,3 binds the ANGPTL3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34718", "l": "15-methylhexadecasphing-4-enine + ATP <=> 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63537", "l": "bradykinin(1-8) + H2O => bradykinin(1-7) + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047821", "l": "D-glutamate oxidase activity", "d": ["Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607756", "l": "TRAF6 oligomer autoubiquitinates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53247", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730862", "l": "Autophosphorylation of LYN kinase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70289", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 3,4,6-trisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48975", "l": "ATP + H2O + phosphite(out) <=> ADP + H(+) + phosphate + phosphite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.22", "l": "\"pectate trisaccharide-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9711058", "l": "SARS-CoV-1 nsp3 deubiquinates K48-linked pUb IkBA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41198", "l": "1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418106", "l": "Packaging of telomere ends (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209910", "l": "Iodide is taken up by thyroid epithelial cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54855", "l": "H(+) + heptan-4-one + NADPH + O2 <=> H2O + NADP(+) + propyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15590", "l": "2-oxoglutarate + D-4-hydroxyphenylglycine => 4-hydroxyphenylglyoxylate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351849", "l": "Caspase-mediated cleavage of Etk (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30910", "l": "(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) <=> 2-methylbutanoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102479", "l": "quercetin 3-O-beta:-D-galactosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-7-olate + UDP-D-galactose <=> quercetin 3-O-beta-D-galactopyranoside + UDP(3-) + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14758", "l": "2 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone => 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69675", "l": "eriodictyol-7-O-beta-D-glucoside + H2O = (S)-eriodictyol + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70971", "l": "citrate <=> isocitrate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390120", "l": "Phosphorylated HPO dimer phosphorylates TH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088130", "l": "PLK1 binds FOXM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20485", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.65", "l": "\"(S)-cheilanthifoline synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709360", "l": "H2O2 reduces MetHb (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-398040", "l": "Gbeta:gamma activation of PLC beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102111", "l": "gibberellin A20,2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A20 + 2-oxoglutarate + O2 <=> gibberellin A29 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52713", "l": "dTMP + H2O => 2-deoxy-D-ribose 5-phosphate + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1362485", "l": "GHBP binds GH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191303", "l": "FDPS dimer transfers IPPP to GPP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.-", "l": "\"Other oxidoreductases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35588", "l": "FMN + H2O => phosphate + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34825", "l": "CO2 + 2 CoA + curcumin => (E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61212", "l": "myricetin + UDP-alpha-D-glucose = H(+) + myricetin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57057", "l": "D-apiofuranose + NAD(+) => D-apionolactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62974", "l": "3 CO2 + 4 CoA + orsellinate => acetyl-CoA + 2 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25301", "l": "acetaldehyde + H2O + NADP(+) <=> acetate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9691621", "l": "C5 binds C5 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047500", "l": "(+)-borneol dehydrogenase activity", "d": ["Catalysis of the reaction: (+)-borneol + NAD+ = (1R, 4R)-camphor + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56437", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48450", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine => H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38864", "l": "phosphate + sucrose 6(F)-phosphate => alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21808", "l": "2,5-dioxopiperazine + H2O = glycylglycine", "d": []}, {"i": "EC:3.5.2.13", "l": "\"2,5-dioxopiperazine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39773", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11374", "l": "AMP + diphosphate + H(+) + L-asparagine => ATP + L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21850", "l": "(Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide => (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351871", "l": "Caspase-mediated cleavage of Z0-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391939", "l": "TP receptor can bind thromboxane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14874", "l": "indole-3-ethanol + NAD(+) => H(+) + indole-3-acetaldehyde + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17147", "l": "2'-hydroxydaidzein + 2 H(+) + NADPH => 2'-hydroxy-2,3-dihydrodaidzein + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57990", "l": "(20S)-ginsenoside F2 + H(+) + UDP => (20S)-ginsenoside Rh2 + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60161", "l": "ATP + H2O + vincristine(in) => ADP + H(+) + phosphate + vincristine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36489", "l": "H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine => agmatine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013004", "l": "RHOA binds effectors at the ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36871", "l": "(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936851", "l": "AHRR binds ARNT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950456", "l": "IL12B dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200646", "l": "Cytosolic folate export across the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67032", "l": "4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] = 4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009817", "l": "Acitretin binds to RAR:RXR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12523", "l": "L-dopa <=> (E)-caffeate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55789", "l": "acetone + H(+) + NADH + O2 => H2O + hydroxyacetone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008727", "l": "GDP-mannose mannosyl hydrolase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106155", "l": "peptidyl-lysine 3-dioxygenase activity", "d": ["Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 3-hydroxy-L-lysine + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350598", "l": "Arginine<=>Agmatine+CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173739", "l": "Spontaneous hydrolysis of C3 thioester (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004867", "l": "serine-type endopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5340226", "l": "CYGB dioxygenates NO (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45133", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20948", "l": "3-sulfopyruvate + H(+) = CO2 + sulfoacetaldehyde", "d": []}, {"i": "EC:4.1.1.79", "l": "\"sulfopyruvate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64742", "l": "3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate => H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27640", "l": "alpha-D-ribose 1-phosphate + xanthine => phosphate + xanthosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951499", "l": "Loading of antigenic peptides on to class I MHC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12262", "l": "ADP + H(+) + NADPH => ATP + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50789", "l": "NADP(+) + pentan-2-one => (E)-pent-3-en-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12493", "l": "L-methionine => D-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13441", "l": "H2O + L-cysteate = H(+) + NH4(+) + pyruvate + sulfite", "d": []}, {"i": "EC:4.4.1.25", "l": "\"L-cysteate sulfo-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033040", "l": "sour taste receptor activity", "d": ["Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49203", "l": "D-mannose 6-phosphate + H2O + phosphoenolpyruvate <=> 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61620", "l": "[(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose = [(1->2)-beta-D-mannosyl](n+1) + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.374", "l": "\"beta-1,2-mannooligosaccharide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74869", "l": "(E)-caffeoyl-CoA + H(+) + NADPH => (E)-caffeyl aldehyde + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691174", "l": "RAC1 binds effectors at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64771", "l": "S-3-(hexan-1-ol)-L-cysteine <=> 2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5195402", "l": "CDK1 phosphorylates LPIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54150", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O => 1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69126", "l": "glycine + indole-3-pyruvate => glyoxylate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74012", "l": "[(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + H(+) + NADPH + O2 => [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21588", "l": "N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH", "d": []}, {"i": "EC:1.2.1.38", "l": "\"N-acetyl-gamma-glutamyl-phosphate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3878123", "l": "Initiation of SAHF formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36656", "l": "desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine => descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26135", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48113", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12952", "l": "D-fuconate <=> 2-dehydro-3-deoxy-D-fuconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465924", "l": "OPN1LW binds 11cRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40637", "l": "2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140598", "l": "lipoprotein carrier activity", "d": ["Binding to and carrying a lipoprotein between two different cellular locations by moving along with the target lipoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37596", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53545", "l": "chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72691", "l": "Formation of the 43S pre-initiation complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22603", "l": "H2O + N-acetyl-9-O-acetylneuraminate <=> acetate + H(+) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25247", "l": "(R)-lactate + glutathione + H(+) => (R)-S-lactoylglutathione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63010", "l": "(6Z)-octadecenoate + NH4(+) => (6Z)-octadecenamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030748", "l": "amine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106301", "l": "arachidonic acid 5,6-epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-5,6-epoxyeicosatrienoic acid."]}, {"i": "RHEA:49936", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46250", "l": "(14Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39066", "l": "NADP(+) + scyllo-inositol <=> H(+) + NADPH + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209365", "l": "Phosphorylated STAT92E dimer transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40720", "l": "an R-cob(III)alamin + apo-[alkylcobalamin reductase] + glutathione => an S-substituted glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17667", "l": "H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein] => L-lysyl-[protein] + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57820", "l": "[phosphate](n) + ADP = [phosphate](n+1) + AMP", "d": []}, {"i": "EC:2.7.4.33", "l": "\"AMP-polyphosphate phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24373", "l": "H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] => H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645692", "l": "C1QBP promotes translocation of p14ARF to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046363", "l": "FGFR4 kinase mutants are inhibited by PD170734 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111883", "l": "Hydrolysis of phosphatidylcholine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52392", "l": "ATP + D-erythronate = 4-phospho-D-erythronate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.220", "l": "\"D-erythronate 4-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40197", "l": "1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102506", "l": "cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose = cyanin betaine + ferulate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75380", "l": "H2O + L-canavanine => L-homoserine + N-hydroxyguanidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432164", "l": "Ca2+ influx into the post-synaptic cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.8", "l": "\"ribosylpyrimidine nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944246", "l": "Association of procollagen type XXI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19702", "l": "a flavonol 3-O-glycoside + UDP-alpha-D-xylose => a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696275", "l": "RND2 binds GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65530", "l": "CoA + hexyl octanoate => hexan-1-ol + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879459", "l": "F-actin capping protein is a heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032032", "l": "myosin I tail binding", "d": ["Binding to the tail region of a myosin I heavy chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168038", "l": "Collagen type XV restin release (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009371", "l": "Binding of AP1 transcriptional activator complexes to CCND1 promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.18.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58250", "l": "ADP-D-ribose + H(+) + L-glutamyl-[protein] => 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-532549", "l": "MPI isomerises Fru6P to Man6P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50090", "l": "21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909738", "l": "SHP1 and SHP2 bind the common beta chain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987214", "l": "p-STAT3 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19102", "l": "2-butyne-1,4-diol + NAD(+) => 4-hydroxy-2-butynal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203712", "l": "eNOS associates with Caveolin-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25213", "l": "H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0055100", "l": "adiponectin binding", "d": ["Binding to adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35802", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O <=> 7,8-dihydroneopterin 3'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728729", "l": "TAS1R2:TAS1R3:sweet compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding TAS1R2:TAS1R3:sweet compound, GNAT3:GTP, and GNB1,3:GNG13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804955", "l": "ATM phosphorylates MDM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43451", "l": "H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12477", "l": "H2O + N-formyl-L-glutamate => formate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72778", "l": "7-carboxymellein + ATP + L-phenylalanine <=> ADP + H(+) + ochratoxin B + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41694", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+) => 1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70302", "l": "H2O + L-dehydroascorbate <=> 2,3-dioxo-L-gulonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46689", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA + A => 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683792", "l": "p-T68-CHEK2 autophosphorylates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23939", "l": "D-gluconate + NADP(+) <=> 5-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691167", "l": "CUL1, SKP1, FBXL5 bind (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13037", "l": "ATP + H(+) + H2O = ITP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390595", "l": "Calcium Binds Troponin-C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201622", "l": "Caspase-mediated cleavage of gelsolin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59083", "l": "bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose <=> 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53823", "l": "chenodeoxycholate + NADP(+) <=> 7-oxolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73840", "l": "ATP + H2O + phenol => AMP + 2 H(+) + phenyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55305", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49409", "l": "[(1->2)-beta-D-mannosyl](n) + phosphate => [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62169", "l": "H2O + N,N'-diacetylchitobiose => acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019785", "l": "ISG15-specific peptidase activity", "d": ["A thiol-dependent isopeptidase activity that cleaves ISG15 from a target protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189456", "l": "Mitochondrial dALA translocates to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62964", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36451", "l": "ATP + glycyl-L-glutamate(out) + H2O = ADP + glycyl-L-glutamate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791109", "l": "GADD45A binds PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610757", "l": "GLI2 is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042961", "l": "ATPase-coupled antimonite transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169895", "l": "Crk's SH3 domain engages C3G (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0045182", "l": "translation regulator activity", "d": ["Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21770", "l": "H(+) + methylamine + NADPH + pyruvate => H2O + N-methyl-L-alanine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12228", "l": "ATP + H2O + L-aspartate + L-glutamine = AMP + diphosphate + H(+) + L-asparagine + L-glutamate", "d": []}, {"i": "EC:6.3.5.4", "l": "\"asparagine synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848414", "l": "Activated PTK6 binds CDKN1B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27281", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4167511", "l": "HLCS biotinylates ACACB (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20212", "l": "ATP + xylitol <=> ADP + H(+) + xylitol 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38315", "l": "chorismate = 3-hydroxybenzoate + pyruvate", "d": []}, {"i": "EC:4.1.3.45", "l": "\"3-hydroxybenzoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129362", "l": "Fibrillin microfibril assembly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674529", "l": "AAMP binds to TBXA2R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21247", "l": "an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine <=> an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44131", "l": "(9E)-octadecenoyl-CoA + hexadecan-1-ol <=> CoA + hexadecanyl (9E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389026", "l": "Galanin receptors can bind galanin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023031", "l": "MHC class Ib protein binding, via lateral surface", "d": ["Binding to a major histocompatibility complex class Ib molecules via the lateral surface."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855187", "l": "IP6 transports from the nucleus to the ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59254", "l": "(E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA => (E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37594", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961651", "l": "E2F1 binds the PCNA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191299", "l": "Squalene is oxidized to its epoxide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018749", "l": "(3,5-dichlorophenylurea)acetate amidohydrolase activity", "d": ["Catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65345", "l": "H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA => (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52495", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73355", "l": "beta-alanyl-[peptidyl-carrier protein] + histamine = carcinine + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74159", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706350", "l": "FLT3 phosphorylates CBL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205649", "l": "p62 links damaged mitochondria to LC3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209925", "l": "DIT and MIT combine to form triiodothyronine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12640", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose <=> (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388809", "l": "CTLA-4 binds B7-1/B7-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197770", "l": "STAB1 (FEEL-1) binds ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.287", "l": "\"phthioceranic/hydroxyphthioceranic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36337", "l": "D-glucarate + 2 H(+) + NADH => D-glucuronate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31740", "l": "a 4'-hydroxyisoflavone + S-adenosyl-L-methionine => a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429683", "l": "CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730862", "l": "Autophosphorylation of LYN kinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22435", "l": "a (3S)-3-hydroxyacyl-CoA + NAD(+) <=> a 3-oxoacyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111930", "l": "Adenylate cyclase produces cAMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39562", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA <=> (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35675", "l": "H(+) + L-serine + tetradecanoyl-CoA = 3-oxohexadecasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35987", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76466", "l": "CYP4A11 12-hydroxylates DDCX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697920", "l": "CLOCK acetylates lysine-10 of histone H3, H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46808", "l": "[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine = [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.318", "l": "\"[trehalose-6-phosphate synthase]-L-cysteine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70390", "l": "3-oxosphinganine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43008", "l": "D-serine = 2-aminoprop-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005456", "l": "CMP-N-acetylneuraminate transmembrane transporter activity", "d": ["Enables the transfer of a CMP-N-acetylneuraminate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373741", "l": "SDK2 homophillic interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0004997", "l": "thyrotropin-releasing hormone receptor activity", "d": ["Combining with thyrotropin-releasing hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017061", "l": "S-methyl-5-thioadenosine phosphorylase activity", "d": ["Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24670", "l": "H2O + hypoxanthine + NAD(+) = H(+) + NADH + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69628", "l": "N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62496", "l": "ATP + H(+) + L-arginine = diphosphate + L-arginyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28761", "l": "alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+) => beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58266", "l": "an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018804", "l": "RAC3 GEFs activate RAC3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692437", "l": "ANG binds F-actin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54379", "l": "(+)-copalyl diphosphate + H2O <=> diphosphate + nezukol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675417", "l": "PEBP1 binds activated RAF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18366", "l": "(R)-malate + NAD(+) => CO2 + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30076", "l": "CMP + H2O => cytosine + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15072", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a <=> chlorophyllide a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045552", "l": "dihydrokaempferol 4-reductase activity", "d": ["Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23672", "l": "a quinone + L-quinate = 3-dehydroquinate + a quinol", "d": []}, {"i": "EC:1.1.5.8", "l": "\"quinate/shikimate dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374662", "l": "Translocation of Ezrin to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55569", "l": "4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine => 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70929", "l": "(R)-glycerate(out) + H(+)(out) => (R)-glycerate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60817", "l": "2-oxoglutarate + gibberellin A14 aldehyde + O2 => CO2 + gibberellin A14 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49196", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol = 25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.109", "l": "\"iron(III) salmochelin esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22885", "l": "glyoxylate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399930", "l": "Activation of PAK by Rac1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034872", "l": "trans-geranyl-CoA isomerase activity", "d": ["Catalysis of the reaction: trans-geranyl-CoA = cis-geranyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102740", "l": "theobromine:S-adenosyl-L-methionine 1-N-methyltransferase activity", "d": ["Catalysis of the reaction: theobromine + S-adenosyl-L-methionine <=> H+ + caffeine + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380048", "l": "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50348", "l": "alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] = a dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37430", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate <=> a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64168", "l": "2-ethyl-L-serine = (2S)-2-aminobutanoate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120298", "l": "peptide noradrenalinyltransferase activity", "d": ["Catalysis of the reaction: (R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)."]}, {"i": "RHEA:66560", "l": "(R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28699", "l": "Mn(2+)(in) = Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24850", "l": "3,4-dihydroxybenzoate + H2O => 3-dehydroshikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52552", "l": "3-dehydro-L-erythronate + ATP = 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60612", "l": "1-octanoyl-sn-glycero-3-phosphocholine = 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35483", "l": "5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437999", "l": "Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-179421", "l": "Degradation of multiubiquitinated Nek2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862300", "l": "LYZ binds bacterial peptidoglycan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050276", "l": "scyllo-inosamine 4-kinase activity", "d": ["Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34775", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) = a 3-oxosteroid + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39876", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol => a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070738", "l": "tubulin-glycine ligase activity", "d": ["Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target tubulin molecule; acts on alpha or beta tubulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.85", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54501", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => beta-geranylfarnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174551", "l": "Formation of alternative pathway C5 convertase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005109", "l": "frizzled binding", "d": ["Binding to a frizzled (fz) receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65925", "l": "2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine => 2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664867", "l": "NBR1 binds MAP1LC3B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26441", "l": "3-hydroxypropanoate + NADP(+) <=> 3-oxopropanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13010", "l": "H2O + N-formyl-L-kynurenine => formate + H(+) + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64075", "l": "acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA <=> 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58812", "l": "ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate = AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": []}, {"i": "EC:5.1.1.23", "l": "\"UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66022", "l": "[collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O => H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65401", "l": "butan-1-ol + butanoyl-CoA => butyl butanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.8", "l": "\"glycerol-3-phosphate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43476", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 = 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26017", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate <=> 3-dehydroquinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53442", "l": "18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69081", "l": "3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+) => 3,4-dihydroxyphenylacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130504", "l": "Cleavage of lip22 to lip10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40160", "l": "H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30990", "l": "(S)-2,3-epoxysqualene <=> (17Z)-protosta-17(20),24-dien-3beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68299", "l": "dodecanoyl-CoA + L-seryl-[protein] <=> CoA + O-dodecanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180005", "l": "RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-threonine (consensus YSPTSPS)(position 4) + H2O = RNA polymerase II large subunit + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48369", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30454", "l": "(S)-2,3-epoxysqualene <=> isomultiflorenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608855", "l": "PRICKLE1 is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030215", "l": "semaphorin receptor binding", "d": ["Binding to a semaphorin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39995", "l": "an N-acylethanolamine + H2O = a fatty acid + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23894", "l": "3-nitroacrylate + H(+) + NADPH => 3-nitropropanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004514", "l": "nicotinate-nucleotide diphosphorylase (carboxylating) activity", "d": ["Catalysis of the reaction: CO2 + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H+ + quinolinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179413", "l": "Activated PKC-alpha  activate MMP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31001", "l": "cucurbitadienol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51378", "l": "CoA + H(+) + N-hexadecanoyl-dopamine => dopamine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33170", "l": "2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21699", "l": "N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38877", "l": "pseudouridine(2604) in 23S rRNA => uridine(2604) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68860", "l": "7-oxo-25-hydroxycholesterol + H(+) + NADPH = 7beta-25-dihydroxycholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102810", "l": "glutarate-semialdehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 5-oxopentanoate + NADP + H2O = glutarate + NADPH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19969", "l": "hydroxylamine + O2 = H(+) + H2O + nitrite", "d": []}, {"i": "EC:1.7.3.6", "l": "\"hydroxylamine oxidase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23044", "l": "H(+) + N,N-dihydroxy-L-tyrosine = (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404200", "l": "IGF1,2 binds IGF1R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850534", "l": "PDCL promotes G-protein beta 5 folding (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34847", "l": "7,8-dihydromonapterin + H(+) + NADPH = 5,6,7,8-tetrahydromonapterin + NADP(+)", "d": []}, {"i": "EC:1.5.1.50", "l": "\"dihydromonapterin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111883", "l": "Hydrolysis of phosphatidylcholine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13433", "l": "2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54803", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein] <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68398", "l": "a carboxylate + H(+) + H2O2 => a percarboxylic acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72388", "l": "2 hydrogencarbonate(out) + sulfate(in) => 2 hydrogencarbonate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52646", "l": "5-phospho-D-xylonate + H(+) => D-xylono-1,4-lactone 5-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11234", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + sulfate => 3'-phosphoadenylyl sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28406", "l": "H2O + XTP = H(+) + phosphate + XDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42656", "l": "diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + H(+) + methanol", "d": []}, {"i": "EC:3.1.1.97", "l": "\"methylated diphthine methylhydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035966", "l": "Defective GGT1 does not hydrolyse GSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12488", "l": "2-amino-2-deoxy-D-gluconate = 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": []}, {"i": "EC:4.3.1.9", "l": "\"glucosaminate ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684018", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70170", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77068", "l": "Activation of GT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33932", "l": "all-trans-zeaxanthin + O2 => (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434018", "l": "Autophosphorylation of chicken IRAK4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12409", "l": "L-lysine + NAD(+) => 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47676", "l": "ATP + N-acetyl-D-galactosamine = ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60770", "l": "3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate => 3 2-oxoglutarate + gibberellin A12 + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52841", "l": "UDP-alpha-D-glucose + vanillate => 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66752", "l": "(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O = (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63323", "l": "a glycerophospholipid(in) + ATP + H2O <=> a glycerophospholipid(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29089", "l": "menaquinol-8 + oxaloacetate => (S)-malate + menaquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39301", "l": "(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+) => (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69665", "l": "beta-D-glucose + luteolin => H2O + luteolin 7-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64332", "l": "ATP + CoA + nicotinate = AMP + diphosphate + nicotinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28871", "l": "D-fructuronate(in) + H(+)(in) = D-fructuronate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25869", "l": "H2O + N(1),N(12)-diacetylspermine + O2 => 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445064", "l": "Activation of Rac1 by VAV2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6795460", "l": "SGK1 phosphorylates MDM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018498", "l": "2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity", "d": ["Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32925", "l": "glycerol + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75007", "l": "H(+)(out) + VO(2+)(out) = H(+)(in) + VO(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15992", "l": "(R)-mevalonate + CoA + 2 NADP(+) <=> (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102898", "l": "levopimaradienol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + levopimaradienol + NADPH + O2 <=> levopiramadiene-diol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209910", "l": "Iodide is taken up by thyroid epithelial cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474210", "l": "Collagen type III degradation by MMP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67394", "l": "2-oxo-AMP + diphosphate + H(+) => 2-oxo-ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688797", "l": "ATXN3 family cleave Ub chains (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106362", "l": "protein-arginine N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H+ + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP."]}, {"i": "RHEA:66632", "l": "L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9650165", "l": "ASIC trimers bind H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102792", "l": "sinapaldehyde:NAD(P)+ oxidoreductase activity", "d": ["Catalysis of the reaction: sinapoyl aldehyde + NADP + H2O <=> 2 H+ + trans-sinapate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18789", "l": "D-glucosamine 6-phosphate = D-galactosamine 6-phosphate", "d": []}, {"i": "EC:5.1.3.42", "l": "\"D-glucosamine-6-phosphate 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52512", "l": "a quinone + trans-4-hydroxy-L-proline = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)", "d": []}, {"i": "EC:1.5.5.3", "l": "\"hydroxyproline dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51663", "l": "an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 <=> an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901241", "l": "4-hydroxyphenylacetate transmembrane transporter activity", "d": ["Enables the transfer of 4-hydroxyphenylacetate from one side of a membrane to the other."]}, {"i": "RHEA:33175", "l": "4-hydroxyphenylacetate(in) = 4-hydroxyphenylacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180000", "l": "histone methyltransferase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a histone methyltransferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30909", "l": "2-methylbutanoyl-CoA + CO2 + NADH => (S)-3-methyl-2-oxopentanoate + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482772", "l": "Release of platelet cytosolic components (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693540", "l": "MRN activates ATM (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696958", "l": "USP44 deubiquitinates CDC20 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37987", "l": "delta-tocopherol = 2-methyl-6-phytyl-1,4-benzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799097", "l": "ATM phosphorylates ZNF420 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0140699", "l": "cyclic GMP-AMP synthase activity", "d": ["Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53713", "l": "2 Fe(III)-heme b => beta-hematin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61725", "l": "a D-glucoside + NAD(+) => a 3-dehydro-D-glucoside + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982709", "l": "G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51655", "l": "D-mannonate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033843", "l": "xyloglucan 6-xylosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-1,6-D-xylosyl-D-glucose linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45237", "l": "(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626914", "l": "α2-agonists bind ADRA2A,B,C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693198", "l": "RHOD binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061981", "l": "3-hydroxykynureninase activity", "d": ["Catalysis of the reaction: L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine."]}, {"i": "RHEA:25143", "l": "3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73544", "l": "dCDP(out) + UTP(in) => dCDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818574", "l": "TASP1 cleaves KMT2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16419", "l": "H(+) + L-glutamate + NADH => (S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047671", "l": "anthranilate adenylyltransferase activity", "d": ["Catalysis of the reaction: anthranilate + ATP = N-adenylylanthranilate + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28616", "l": "(2S)-2-methylbutanenitrile + H2O => (1Z,2S)-2-methylbutanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11865", "l": "H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine => dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.16", "l": "\"geosmin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682258", "l": "nsp14 binds nsp12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004095", "l": "carnitine O-palmitoyltransferase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2247511", "l": "STAB2:ligand is endocytosed (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39083", "l": "3-oxododecanedioyl-CoA + CoA = acetyl-CoA + decanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28413", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) <=> 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68757", "l": "4 (R)-3-phenyllactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022B + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55504", "l": "(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] = (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.72", "l": "\"drimenol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072582", "l": "17-beta-hydroxysteroid dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: a 17-beta-hydroxysteroid + NADP+ = a 17-oxosteroid + NADPH + H+."]}, {"i": "RHEA:69284", "l": "a 17beta-hydroxy steroid + NADP(+) = a 17-oxo steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34010", "l": "7-dehydrodesmosterol + S-adenosyl-L-methionine <=> 5-dehydroepisterol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734713", "l": "ORC6 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12923", "l": "5-aminolevulinate + CO2 + CoA => glycine + H(+) + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299657", "l": "Defective TCII does not bind Cbl in the circulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474210", "l": "Collagen type III degradation by MMP14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67089", "l": "ATP + H2O + tetracosanoate(in) => ADP + H(+) + phosphate + tetracosanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69745", "l": "(S)-2-benzylsuccinyl-CoA + succinate => (S)-2-benzylsuccinate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34690", "l": "AH2 + N-acyl-15-methylhexadecasphinganine + O2 <=> A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66157", "l": "butanoyl-CoA + tyramine => CoA + H(+) + N-butanoyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050018", "l": "L-amino-acid dehydrogenase activity", "d": ["Catalysis of the reaction: an L-amino acid + H2O + NAD+ = a 2-oxo acid + NH3 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.47", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39189", "l": "(2E)-docosenoyl-CoA + H2O => (3R)-hydroxydocosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68060", "l": "a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013023", "l": "RHOB GEFs activate RHOB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031702", "l": "type 1 angiotensin receptor binding", "d": ["Binding to a type 1 angiotensin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875451", "l": "MET phosphorylates CBL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52400", "l": "4-O-phospho-D-threonate + NAD(+) = 3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984708", "l": "Kinesin-2 is a heterotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961699", "l": "FBXO5 gene expression is stimulated by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189488", "l": "UROS transforms HMB to URO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75287", "l": "glyoxylate(in) + sulfate(out) = glyoxylate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446634", "l": "IRAK4 is activated by autophosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680385", "l": "CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800380", "l": "PTPRD binds IL1RAP-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726621", "l": "PGR binds PGR antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372819", "l": "PCK2 phosphorylates OA to yield PEP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47633", "l": "H2O + L-arginine + NAD(+) => 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45125", "l": "acarbose + ATP => acarbose 7(IV)-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015161", "l": "lipid III floppase activity", "d": ["Enables the transbilayer of capsular-polysaccharides (Und-PP-GlcNAc-ManNAcA-Fuc4NAc (lipid III)) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of ECA. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64428", "l": "glycyl-L-proline(out) + H(+)(out) = glycyl-L-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070326", "l": "very-low-density lipoprotein particle receptor binding", "d": ["Binding to a very-low-density lipoprotein receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031691", "l": "alpha-1A adrenergic receptor binding", "d": ["Binding to an alpha-1A adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25001", "l": "H(+) + N,N-dihydroxy-L-phenylalanine => (E)-phenylacetaldehyde oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814096", "l": "ARL1:GTP binds SCOC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62009", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23398", "l": "1,3,5-trihydroxybenzene + H(+) + phloretate => H2O + phloretin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445448", "l": "HHIP binds Hedgehog (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031423", "l": "hexon binding", "d": ["Binding to a hexon, the major protein component of the icosahedral capsid of an adenovirus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13693", "l": "(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)", "d": []}, {"i": "EC:2.1.1.19", "l": "\"trimethylsulfonium--tetrahydrofolate N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49887", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373724", "l": "Nephrin binds NCK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982645", "l": "GRKs bind ADRB2:Catecholamine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693347", "l": "HTR1A binds 5HT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247843", "l": "secretion of WNT ligands (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357472", "l": "PAK1-3 autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202717", "l": "Heterodimerization of CEACAMs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424485", "l": "Release of p-PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61508", "l": "peonidin + UDP-alpha-D-glucose = peonidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32736", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73150", "l": "adenosine 3',5'-bisphosphate(out) + FAD(in) <=> adenosine 3',5'-bisphosphate(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32096", "l": "acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose => CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43737", "l": "adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11164", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.17", "l": "\"phosphatidylethanolamine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009488", "l": "IL34 binds CSF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210881", "l": "Dimerization of Tie2/Ang1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13576", "l": "[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate <=> [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750666", "l": "ALB binds ST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036412", "l": "acetyl-CoA:oxalate CoA-transferase", "d": ["Catalysis of the reaction: acetyl-CoA + oxalate = acetate + oxalyl-CoA."]}, {"i": "RHEA:37883", "l": "acetyl-CoA + oxalate = acetate + oxalyl-CoA", "d": []}, {"i": "EC:2.8.3.19", "l": "\"CoA:oxalate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.177", "l": "\"ultra-long-chain fatty acid omega-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69131", "l": "glyoxylate + L-leucine <=> 4-methyl-2-oxopentanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54300", "l": "n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate = n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45331", "l": "7,8-dihydroneopterin <=> 7,8-dihydromonapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65308", "l": "an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.294", "l": "\"meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44787", "l": "2-demethylmenaquinol-10 + S-adenosyl-L-methionine <=> H(+) + menaquinol-10 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389857", "l": "Peptide transfer from P-site to A-site (peptide bond formation) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977371", "l": "Factor I inactivates Factor H-boundC3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0030159", "l": "signaling receptor complex adaptor activity", "d": ["The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-741411", "l": "CYLD deubiquitinates NEMO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14374", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58454", "l": "H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209296", "l": "SU(VAR)2-10 binds to the phosphorylated STAT92E dimer and inhibits transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050547", "l": "vanillin synthase activity", "d": ["Catalysis of the reaction: 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = acetyl-CoA + vanillin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13974", "l": "diphosphate + H(+)(in) + H2O => 2 H(+)(out) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38921", "l": "choline + H(+) + sphing-4-enine 1-phosphate => H2O + sphing-4-enine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62819", "l": "4 monapinone E + O2 <=> 2 dinapinone E + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73713", "l": "ATP(out) + UTP(in) => ATP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31422", "l": "(2Z,6E)-farnesyl diphosphate <=> (-)-beta-curcumene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73729", "l": "Formation of SL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66894", "l": "10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050529", "l": "polyneuridine-aldehyde esterase activity", "d": ["Catalysis of the reaction: H2O + polyneuridine aldehyde = 16-epivellosimine + CO2 + methanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429497", "l": "SLP-76 stimulates PLC gamma 2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65565", "l": "(9Z)-octadecenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35723", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382096", "l": "Formation of NR-NCOR Corepressor Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69827", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R,23R)-22,23-dihydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59010", "l": "H(+) + H2O2 + salicylate => H2O + O2 + salicylaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52793", "l": "chlorophyllide a + 2 H(+) => Mg(2+) + pheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696670", "l": "CHD1L is recruited to GG-NER site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37969", "l": "D-galactose + H(+) + NADPH => galactitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53662", "l": "(5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191784", "l": "snRNA Cap hypermethylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33015", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 = [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.160", "l": "\"(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA 1,5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010328", "l": "auxin influx transmembrane transporter activity", "d": ["Enables the transfer of auxin, from one side of a membrane to the other, into a cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16514", "l": "(S)-lactate + O2 => acetate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44503", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52411", "l": "4-phospho-D-erythronate + NAD(+) <=> CO2 + dihydroxyacetone phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042781", "l": "3'-tRNA processing endoribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30889", "l": "7,8-dihydropteroate + H2O => 4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71050", "l": "glycine(in) + L-phenylalanine(out) <=> glycine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22375", "l": "H2O + O2 + propionate 3-nitronate <=> 3-oxopropanoate + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24152", "l": "adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.25", "l": "\"adenylyl-sulfate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38956", "l": "an N-acylsphing-4-enine 1-phosphate(in) => an N-acylsphing-4-enine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57594", "l": "(2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33835", "l": "H2O + N-hexacosanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + hexacosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6786421", "l": "CHIA hydrolyses chitin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3204311", "l": "AOX1 oxidises PXL to PDXate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59108", "l": "chenodeoxycholate + octyl beta-D-glucose = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64406", "l": "carnosine(in) + H(+)(in) => carnosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51950", "l": "2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754518", "l": "SARS-CoV-2 3a tetramer binds to CAV1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017105", "l": "acyl-CoA delta11-(Z)-desaturase activity", "d": ["Catalysis of the reaction: an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an (11Z)-delta-11-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41845", "l": "(3R)-hydroxyoctanoyl-[ACP] => (2E)-octenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794523", "l": "SLC22A1 transports Cipro into renal cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112037", "l": "Inactivation of PLC beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-426032", "l": "DAG is metabolized by DAGL to 2-AG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016402", "l": "pristanoyl-CoA oxidase activity", "d": ["Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67061", "l": "asnovolin I + S-adenosyl-L-methionine => asnovolin K + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389350", "l": "Activation of Cdc42 by pVav1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9612501", "l": "SGK phosphorylates CREB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847537", "l": "RAB43:GTP binds USP8NL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59475", "l": "2',3'-cGAMP + H2O <=> Gp(2'-5')Ap(3') + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0008112", "l": "nicotinamide N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58899", "l": "4-hydroxybutanoate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396370", "l": "VTN binds collagens II, III and V (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205289", "l": "Autophosphorylation of KIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002172", "l": "high-affinity IgM receptor activity", "d": ["Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70035", "l": "6-deoxotyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099508", "l": "voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "d": ["Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65637", "l": "sphinga-(4E,8E)-dienine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30207", "l": "H2O + methylamine + 2 oxidized [amicyanin] = formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]", "d": []}, {"i": "EC:1.4.9.1", "l": "\"methylamine dehydrogenase (amicyanin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59975", "l": "decanoyl-CoA + L-seryl-[protein] <=> CoA + O-decanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25542", "l": "diphosphate + ent-pimara-8(14),15-diene => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17870", "l": "5,6,7,8-tetrahydropteridine + NAD(+) => 6,7-dihydropteridine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45109", "l": "(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] => 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070404", "l": "NADH binding", "d": ["Binding to the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52155", "l": "(Z)-2-(indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose <=> (Z)-indolylmethyl desulfoglucosinolate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47045", "l": "3-dehydrocarnitine + acetyl-CoA => acetoacetate + N,N,N-trimethylglycyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29147", "l": "2 H(+)(in) + nitrate + ubiquinol-8 = 2 H(+)(out) + H2O + nitrite + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103089", "l": "methylthiohexylmalate isomerase activity", "d": ["Catalysis of the reaction: 2-(6'-methylthio)hexylmalate <=> 3-(6'-methylthio)hexylmalate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71276", "l": "2 Na(+)(out) + taurolithocholate 3-sulfate(out) => 2 Na(+)(in) + taurolithocholate 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247569", "l": "PADI4 deiminates Histones (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32874", "l": "a 2-acylglycerol + H2O <=> a carboxylate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177284", "l": "PKA phosphorylates PDE4B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2213207", "l": "Formation of collagen networks (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362416", "l": "Frataxin binds iron (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247922", "l": "GGCT transforms gGluCys to OPRO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52326", "l": "5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin] => 2 L-arginine + 4 O2 + 3 reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050112", "l": "inositol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35354", "l": "NADP(+) + octadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879222", "l": "MDP:NLRP1 binds ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45394", "l": "(9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine => H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28013", "l": "propanoyl-CoA + succinate <=> propanoate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.37", "l": "\"cis-2-enoyl-CoA reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950766", "l": "IL27RA dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18819", "l": "acetate + malonyl-CoA => acetyl-CoA + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28772", "l": "(2E)-hexadecenoyl-CoA => (9Z)-hexadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14146", "l": "ATP + guanidinoacetate => ADP + H(+) + phosphoguanidinoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0005035", "l": "death receptor activity", "d": ["Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37077", "l": "2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20453", "l": "scopoletin + UDP-alpha-D-glucose = H(+) + scopolin + UDP", "d": []}, {"i": "EC:2.4.1.128", "l": "\"scopoletin glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-517674", "l": "p-S158,221-HuR binds mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75078", "l": "dihydro-6-demethylsterigmatocystin + S-adenosyl-L-methionine <=> dihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35404", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) => (3R)-vestitone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32961", "l": "(S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-isoleucine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47053", "l": "(2E,6E)-farnesyl diphosphate => alpha-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654399", "l": "Activated FGFR2 binds FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050462", "l": "N-acetylneuraminate synthase activity", "d": ["Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41891", "l": "3-oxotetradecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36164", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate => ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665280", "l": "ERBB2 KD mutants do not bind osimertinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48234", "l": "CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde => acetyl-CoA + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106324", "l": "(S)-limonene 1,2-monooxygenase NADH activity", "d": ["Catalysis of the reaction: (4S)-limonene + NADH + H+ + O2 = NAD+ + H2O + (4S)-limonene-1,2-epoxide."]}, {"i": "RHEA:26089", "l": "(4S)-limonene + H(+) + NADH + O2 = H2O + limonene 1,2-epoxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632412", "l": "PTK2 is recruited to methylated ESR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23881", "l": "L-histidyl-[protein] + phosphoenolpyruvate => N(pros)-phospho-L-histidyl-[protein] + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67319", "l": "(2S,4R)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine <=> (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201515", "l": "Active ALK recruits PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2769008", "l": "NOTCH1 PEST domain mutants bind DLL1  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37323", "l": "glycyl-L-methionine + H2O = glycine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60785", "l": "2-oxoglutarate + gibberellin A24 + O2 => CO2 + gibberellin A25 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31879", "l": "(S)-2,3-epoxysqualene = beta-seco-amyrin", "d": []}, {"i": "EC:5.4.99.54", "l": "\"beta-seco-amyrin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102816", "l": "UDP-D-glucose:delphinidin 3-O-glucosyl-5-O-caffeoylglucoside -O-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-glucosyl-5-O-caffeoylglucoside <=> H+ + delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26301", "l": "5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) = (S)-allantoin + CO2", "d": []}, {"i": "EC:4.1.1.97", "l": "\"2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20444", "l": "L-cysteine + O2 <=> 3-sulfino-L-alanine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39283", "l": "a long-chain fatty acid(out) = a long-chain fatty acid(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22029", "l": "acetyl-CoA + taxa-4(20),11-dien-5alpha-ol => CoA + taxa-4(20),11-dien-5alpha-yl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49041", "l": "(-)-5'-demethylyatein + S-adenosyl-L-methionine => (-)-yatein + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247844", "l": "WNT ligands traffic to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49458", "l": "(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate => (2S)-2-amino-4-deoxychorismate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20379", "l": "5alpha-androstan-3,17-dione + H(+) + NADPH => androsterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9612219", "l": "ERBB4s80 binds to SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23891", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine <=> [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694583", "l": "ABHD4 hydrolyses NAPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043887", "l": "melibiose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + Na+(out) = melibiose(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0050355", "l": "inorganic triphosphate phosphatase activity", "d": ["Catalysis of the reaction: H2O + inorganic triphosphate = diphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640167", "l": "RRAGA,B exchanges GDP for GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247839", "l": "Retromer associates with WLS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034900", "l": "3-(N-formyl)-formiminopyruvate hydrolase activity", "d": ["Catalysis of the reaction: 3-(N-formyl)-formiminopyruvate + H2O = 3-formiminopyruvate + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265936", "l": "Phosphorylation of RPA2 by CDC2 kinase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848606", "l": "PTK6 phosphorylates PXN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865275", "l": "PDGF-BB clevage by Furin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59153", "l": "ATP + CoA + pseudomonate C => AMP + diphosphate + pseudomonoyl-CoA C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31660", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O => 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71476", "l": "H2O + neurotensin => L-isoleucyl-L-leucine + neurotensin(1-11)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650473", "l": "SERPING1 is secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44595", "l": "3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706287", "l": "Active FLT3 binds to ABL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430347", "l": "MigFilin associates with Filamin and F-actin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610723", "l": "GLI proteins bind SUFU (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58954", "l": "(20S)-ginsenoside Rh1 + H(+) + UDP => (20S)-protopanaxatriol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904928", "l": "coreceptor activity involved in canonical Wnt signaling pathway", "d": ["Any coreceptor activity that is involved in a canonical Wnt signaling pathway."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675198", "l": "Activated MAPKs phosphorylate BRAF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55183", "l": "2-oxoglutarate + 3-methylnonanoyl-CoA + O2 <=> 2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109702", "l": "PDPK1 phosphorylates AKT2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65523", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389580", "l": "formyl-CoA + H2O => formate + CoASH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695853", "l": "FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15220", "l": "ecdysone + hexadecanoyl-CoA <=> CoA + ecdysone hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53393", "l": "2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] => (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9726580", "l": "PGR binds PGR agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31042", "l": "dodecanoyl-CoA + FAD + H(+) <=> (2E)-dodecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264458", "l": "Proteasome mediated degradation of COP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534096", "l": "METAP1/2 demethylates GNAT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72194", "l": "cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727819", "l": "TAK1 phosphorylates MKK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018573", "l": "NOTCH3 binds activated EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31633", "l": "phosphate + pseudaminate => 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31180", "l": "(3S)-3-hydroxydodecanoyl-CoA + NAD(+) => 3-oxododecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870698", "l": "FASLG (FasL) gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56613", "l": "L-cysteinyl-[protein] + NAD(+) => H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940561", "l": "MMP7 cleaves OPTC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23302", "l": "(2Z,6E)-farnesyl diphosphate + diphosphate => (2E)-geranyl diphosphate + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0140776", "l": "protein-containing complex destabilizing activity", "d": ["A molecular function that involves direct binding to one of the subunits of a protein-containing complex and promoting the dissociation of one or many subunits. This often happens by changing the conformation of the protein being bound, which decreases its affinity for the rest of the complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626928", "l": "CREBBP binds FOXO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66978", "l": "alpha-D-Abe-(1->3)-alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+) => alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39452", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA => (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.4", "l": "\"thymidine phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67211", "l": "H2O + melatonin <=> 5-methoxytryptamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61753", "l": "steviolbioside + UDP-alpha-D-glucose => H(+) + rebaudioside B + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21524", "l": "3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.13", "l": "\"2-isopropylmalate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418845", "l": "Activation of caspase-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770072", "l": "NPAS4 binds SYT10 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57233", "l": "GDP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2317314", "l": "AKT binds PDPK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102624", "l": "scutellarein 7-methyl ether 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: scutellarein 7-methyl ether + S-adenosyl-L-methionine <=> ladanein + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42240", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18403", "l": "(S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21271", "l": "(R)-canadine + 2 NADP(+) <=> berberine + H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52653", "l": "lanosterol + S-adenosyl-L-methionine => eburicol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13528", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] <=> (1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37081", "l": "2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine => 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654651", "l": "Activated FGFR4 binds FRS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821395", "l": "PAXIP1 binds PAGR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853496", "l": "SCF:FBXL7 binds AURKA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64295", "l": "3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH <=> (3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58055", "l": "(2-aminoethyl)phosphonate + acetyl-CoA <=> (2-acetamidoethyl)phosphonate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198611", "l": "AKT phosphorylates IKKalpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51672", "l": "glyoxal + H2O = glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20617", "l": "L-galactono-1,4-lactone + O2 = H(+) + H2O2 + L-ascorbate", "d": []}, {"i": "EC:1.3.3.12", "l": "\"L-galactonolactone oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64681", "l": "benzoyl-CoA + ethanol => CoA + ethyl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9639286", "l": "RRAGC,D exchanges GTP for GDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35615", "l": "hydroxyacetone + NAD(+) = H(+) + methylglyoxal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1006143", "l": "CD46 binds C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20892", "l": "butanoyl-CoA + phosphate = butanoyl phosphate + CoA", "d": []}, {"i": "EC:2.3.1.19", "l": "\"phosphate butyryltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.116", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18622", "l": "2-oxoglutarate + a (2S)-flavan-4-one + O2 => a (2R,3R)-dihydroflavonol + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0030983", "l": "mismatched DNA binding", "d": ["Binding to a double-stranded DNA region containing one or more mismatches."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68871", "l": "ATP + benzoate + H(+) + NADPH <=> AMP + benzaldehyde + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31698", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71986", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + fusoxypene B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214393", "l": "Phosphorylated REL is cleaved by and dissociates from DREDD in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448702", "l": "Caspase-1 active tetramer formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69305", "l": "(Z)-glucotropeolin + H2O => (Z)-phenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.369838362782886", "identifiers": [{"i": "GO:0016868", "l": "intramolecular transferase activity, phosphotransferases", "d": ["Catalysis of the transfer of a phosphate group from one position to another within a single molecule."]}, {"i": "EC:5.4.2.-", "l": "\"Phosphotransferases (phosphomutases)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77094", "l": "Formation of cap binding complex (CBC) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52840", "l": "UDP-alpha-D-glucose + vanillate = 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.25", "l": "\"methane monooxygenase (soluble)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24253", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => 2 ADP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38908", "l": "(R)-reticuline + S-adenosyl-L-methionine => (R)-laudanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617661", "l": "MAFB:JUN and EGR2 activate HOXB3 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56766", "l": "12-epi-fischerindole G + CO2 + H2O + succinate => 12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29813", "l": "ADP + H(+) + phosphate + thiamine(in) => ATP + H2O + thiamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418200", "l": "SRC-1 bound to ARRB2 is not activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59843", "l": "(6S)-5,6,7,8-tetrahydrofolate + syringate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75079", "l": "Formation of AT-AC C complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349404", "l": "CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29336", "l": "H2O + L-alanyl-L-glutamate => L-alanine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12892", "l": "L-gulonate + NAD(+) <=> 3-dehydro-L-gulonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58568", "l": "15alpha-stemmadenine + acetyl-CoA = CoA + O-acetyl-15alpha-stemmadenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63778", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692809", "l": "CDC42 binds effectors at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15138", "l": "galactitol 1-phosphate + NAD(+) => H(+) + keto-L-tagatose 6-phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853405", "l": "TPX2 binds AURKA at centrosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31950", "l": "ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39808", "l": "octadecanoate(in) => octadecanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636296", "l": "Mce3E binds MAPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000103", "l": "CUBN:AMN binds CBLIF:RCbl (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61239", "l": "H2O + L-methionine + O2 <=> 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52967", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate <=> H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696183", "l": "AOC3 deaminates BZAM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964851", "l": "Dehydratation of DHQ yields DHS (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981621", "l": "Neuroglobin:oxygen dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952128", "l": "RUNX3 binds TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043560", "l": "insulin receptor substrate binding", "d": ["Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52565", "l": "2-dehydro-L-erythronate => 3-dehydro-L-erythronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-482770", "l": "Release of platelet secretory granule components (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008923", "l": "lysine decarboxylase activity", "d": ["Catalysis of the reaction: L-lysine + H+ = cadaverine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55766", "l": "2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol => 1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31555", "l": "(5S)-5-amino-3-oxohexanoate + acetyl-CoA = (3S)-3-aminobutanoyl-CoA + acetoacetate", "d": []}, {"i": "EC:2.3.1.247", "l": "\"3-keto-5-aminohexanoate cleavage enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134800", "l": "STING dimerization (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63915", "l": "6-azauridine + ATP <=> 6-azauridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72926", "l": "O2 + proatranorin II + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41865", "l": "(2E)-decenoyl-[ACP] + H(+) + NADPH => decanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35213", "l": "dIMP + H(+) + phosphate => dIDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051959", "l": "dynein light intermediate chain binding", "d": ["Binding to a light intermediate chain of the dynein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43167", "l": "7-cyano-7-deazaguanine + guanosine(15) in tRNA <=> 7-cyano-7-carbaguanosine(15) in tRNA + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799199", "l": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47060", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76386", "l": "CYP1A2 S-demethylates 6MMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694553", "l": "Recruitment of Spike trimer to assembling virion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762343", "l": "PREDL:ALB dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16248", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788611", "l": "HYKK phosphorylates 5HLYS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22469", "l": "GTP + 3 H2O => 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27952", "l": "L-phenylalanine(out) => L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800298", "l": "HGF dimer binds MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49536", "l": "2-amino-2-deoxy-D-gluconate = (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392749", "l": "Transport of L1 into endosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39944", "l": "a 1-acylglycerol + an acyl-CoA => a 1,2-diacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11952", "l": "3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate", "d": []}, {"i": "EC:5.3.1.22", "l": "\"hydroxypyruvate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9669893", "l": "KIT binds type I TKIs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45869", "l": "9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43251", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O <=> 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69129", "l": "glyoxylate + L-leucine => 4-methyl-2-oxopentanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65008", "l": "ATP + decanoate + H(+) = decanoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047911", "l": "galacturan 1,4-alpha-galacturonidase activity", "d": ["Catalysis of the reaction: [(1->4)-alpha-D-galacturonide](n) + H2O = [(1->4)-alpha-D-galacturonide](n-1) + D-galacturonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20728", "l": "H2O + L-glutamate + O2 = 2-oxoglutarate + H2O2 + NH4(+)", "d": []}, {"i": "EC:1.4.3.11", "l": "\"L-glutamate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46432", "l": "(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33925", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+) => (1R,4R)-5-oxo-1,2-campholide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57727", "l": "H(+) + 2 Na(+)(in) + oxaloacetate <=> CO2 + 2 Na(+)(out) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694641", "l": "Viral release (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12680", "l": "AH2 + Latia luciferin + 2 O2 <=> A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004138", "l": "deoxyguanosine kinase activity", "d": ["Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008919", "l": "lipopolysaccharide glucosyltransferase I activity", "d": ["Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47083", "l": "17beta-hydroxyestr-4-en-3-one + H(+) + NADPH <=> 17beta-hydroxy-5beta-estran-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-179410", "l": "Association of Nek2A with MCC:APC/C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018718", "l": "1,2-dihydroxy-phenanthrene glycosyltransferase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxyphenanthrene + UDP-glucose = 2-hydroxy-1-phenanthryl-beta-D-glucopyranoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174235", "l": "Association of Emi1 with Cdc20 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873921", "l": "Binding of STAT1 to p-IFNGR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66190", "l": "3',5'-cyclic GMP(out) + ADP + H(+) + phosphate => 3',5'-cyclic GMP(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21176", "l": "L-idonate + NADP(+) = 5-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12248", "l": "NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": []}, {"i": "EC:1.3.1.98", "l": "\"UDP-N-acetylmuramate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211960", "l": "CYP2U1 19-hydroxylates ARA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018814", "l": "RHOT1 hydrolyzes GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32733", "l": "a fatty acid + a monoacylglycerol + H(+) => a diacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53855", "l": "glycocholate + NAD(+) <=> 7-oxo-glycodeoxycholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64266", "l": "atrochrysone + CO2 => atrochrysone carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69699", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + H2O = beta-D-glucose + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11832", "l": "(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) = H(+) + NADH + naphthalene-1,2-diol", "d": []}, {"i": "EC:1.3.1.29", "l": "\"cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2514831", "l": "Fibrillin-1 degradation by MMP14 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102748", "l": "geranylgeranyl-chlorophyll a reductase activity", "d": ["Catalysis of the reaction: H+ + geranylgeranyl-chlorophyll a + NADPH = dihydrogeranylgeranyl-chlorophyll a + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134914", "l": "Beta-catenin migrates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67949", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose => 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36040", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46979", "l": "(S)-6-hydroxynicotine + O2 <=> 6-hydroxy-N-methylmyosmine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670428", "l": "KIT mutants bind GRB2-SOS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43136", "l": "guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.215", "l": "\"tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54913", "l": "11-cis-retinol + NADP(+) => 11-cis-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730872", "l": "Activation of Calcineurin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70631", "l": "H2O + N(6)-decanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-decanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21993", "l": "acetyl-CoA + L-lysyl-[histone] => CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53795", "l": "benzylthiol + O2 <=> benzothialdehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32853", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50477", "l": "anthraniloyl-CoA + L-cysteinyl-[PqsD protein] => CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66929", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O => a (N(7)-methyl 5'-triphospho-guanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674546", "l": "CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22490", "l": "formaldehyde + glutathione => S-(hydroxymethyl)glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70014", "l": "2-aminobenzoyl-AMP + CoA <=> AMP + anthraniloyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928614", "l": "EFNB:GRB4 binds GIT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47253", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56407", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9709179", "l": "DPP4 binds DPP4 inhibitors (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29614", "l": "H2O + NADP(+) + nitrous oxide <=> H(+) + NADPH + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21517", "l": "isopiperitenone => piperitenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168909", "l": "viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57249", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP => dGTP + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20129", "l": "AMP + H2O = adenine + D-ribose 5-phosphate", "d": []}, {"i": "EC:3.2.2.4", "l": "\"AMP nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451649", "l": "TPL2 phosphorylates MEK1, SEK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39229", "l": "NADP(+) + octacosanoyl-CoA => (2E)-octacosenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070747", "l": "interleukin-35 receptor activity", "d": ["Combining with interleukin-35 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52274", "l": "gramine + H(+) + S-adenosyl-L-homocysteine => (1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61700", "l": "glycyl-5'-AMP + holo-[peptidyl-carrier protein] = AMP + glycyl-[peptidyl-carrier protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39386", "l": "3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53058", "l": "H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine => 4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32082", "l": "(13E)-labda-7,13-dien-15-yl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866277", "l": "AP-2 directly binds some endocytic cargo (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70702", "l": "H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out) <=> H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44372", "l": "Cr(6+) + 2 NADH + O2 = Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49125", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate => H2O + NADP(+) + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019825", "l": "oxygen binding", "d": ["Binding to oxygen (O2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62713", "l": "betaenone C + H(+) + NADPH + O2 => H2O + NADP(+) + stemphyloxin I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20218", "l": "H(+) + trimethylamine N-oxide => dimethylamine + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30362", "l": "chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 <=> chlorophyllide b + 3 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429815", "l": "Formation Of Bloc-1 Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28107", "l": "galactitol 1-phosphate + NAD(+) => H(+) + keto-D-tagatose 6-phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60840", "l": "a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12859", "l": "L-glutamate => (2S,3S)-3-methyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800490", "l": "ATM phosphorylates PIDD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36415", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.98", "l": "\"diphthine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70716", "l": "glycine(in) => glycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53121", "l": "(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+) => 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5622134", "l": "CRABP1 binds atRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51848", "l": "8-methylmenaquinone-6 + succinate = 8-methylmenaquinol-6 + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113429", "l": "Elongating transcript encounters a lesion in the template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.132", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004783", "l": "sulfite reductase (NADPH) activity", "d": ["Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72654", "l": "1,6-dihydroxyphenazine N(5)-oxide + NADPH + O2 <=> 1,6-dihydroxyphenazine N(5),N(10)-dioxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53696", "l": "2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000907", "l": "sulfonate dioxygenase activity", "d": ["Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46658", "l": "5beta-androstane-3,17-dione + NADP(+) => androst-4-ene-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68516", "l": "(2Z,6Z)-farnesyl diphosphate = beta-acoradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0015573", "l": "beta-glucoside transmembrane transporter activity", "d": ["Enables the transfer of beta-glucosides from one side of a membrane to the other. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72799", "l": "L-arginine(out) + L-homoarginine(in) = L-arginine(in) + L-homoarginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66918", "l": "9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9681375", "l": "KIT binds ripretinib (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665727", "l": "FMNL2 binds CDC42:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38913", "l": "26-desgluco-avenacoside B + D-glucose => avenacoside B + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196417", "l": "Reduction of desmosterol to cholesterol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28199", "l": "(S)-1-phenylethanol + NAD(+) => acetophenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59084", "l": "2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420202", "l": "Secretin receptor binds secretin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66765", "l": "ATP + folate(in) + H2O => ADP + folate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052737", "l": "pyruvate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112429", "l": "Formation of FACT complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11335", "l": "ATP + RNA(n) <=> diphosphate + RNA(n)-3'-adenine ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149519", "l": "MMACHC decyanates CNCbl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18222", "l": "1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O => a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52142", "l": "a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+) => a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75482", "l": "S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) <=> S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28270", "l": "acetyl-CoA + spermidine = CoA + H(+) + N(8)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68024", "l": "H2O + presqualene monophosphate = phosphate + presqualene alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38590", "l": "UDP-alpha-D-glucose + vancomycin aglycone <=> devancoaminyl-vancomycin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63898", "l": "isoaspulvinone E => aspulvinone E + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450054", "l": "Interleukin-2 receptor alpha binds interleukin-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64343", "l": "(2E,6E)-farnesyl diphosphate + 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one <=> 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201608", "l": "Caspase-mediated cleavage of alpha adducin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10565", "l": "H2O + oxaloacetate 4-methyl ester => H(+) + methanol + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0090369", "l": "ornithine carbamoyltransferase inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of ornithine carbamoyltransferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44871", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol <=> 1,2-diacyl-sn-glycero-3-phosphoethanol + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58016", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65596", "l": "4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] = 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045548", "l": "phenylalanine ammonia-lyase activity", "d": ["Catalysis of the reaction: L-phenylalanine = NH4 + trans-cinnamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10614", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64387", "l": "H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine <=> alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45282", "l": "12-hydroxyoctadecanoate + phosphate => 12-(phosphooxy)octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139905", "l": "Translocation of activated BAD protein to mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45151", "l": "3-(methylsulfanyl)acryloyl-CoA + H2O <=> 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71022", "l": "L-phenylalanine(out) + L-valine(in) <=> L-phenylalanine(in) + L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54684", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (-)-kolavenyl diphosphate", "d": []}, {"i": "EC:5.5.1.28", "l": "\"(-)-kolavenyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36546", "l": "H2O + mycothiol S-conjugate <=> 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53644", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether B + diphosphate", "d": []}, {"i": "EC:4.2.3.163", "l": "\"(+)-corvol ether B synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191072", "l": "Synthesis of Cx43 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694409", "l": "Nucleotide exchange on RAB1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24790", "l": "(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010210", "l": "IAA-Phe conjugate hydrolase activity", "d": ["Catalysis of the reaction: indole-3-acetyl-phenylalanine + H2O = indole-3-acetate + phenylalanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450975", "l": "isocitrate <=> citrate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660980", "l": "p-S276-RELA binds RELB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851888", "l": "MET binds SHC1-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14103", "l": "[eIF5A protein]-hypusine + A + H2O => [eIF5A protein]-deoxyhypusine + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34968", "l": "sn-glycerol 3-phosphate(in) => sn-glycerol 3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200406", "l": "CPT1A,B transfers PALM to CAR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68558", "l": "H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => NAD(+) + UDP-N-acetyl-alpha-D-quinovosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65543", "l": "ganglioside GM3 + H2O <=> an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687097", "l": "p-S857 NCOA3 binds ETV4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67860", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] = 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59400", "l": "L-2-aminohexanoate = D-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58279", "l": "6 ATP <=> cyclic hexaadenylate + 6 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0070492", "l": "oligosaccharide binding", "d": ["Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797553", "l": "Protein 4.1 binds CASK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50374", "l": "an N-acylsphingoid base 1-phosphate(out) => an N-acylsphingoid base 1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38764", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53914", "l": "CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein] => butanoyl-CoA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65941", "l": "(R)-glycerate + GDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168374", "l": "RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.24", "l": "\"cathepsin T\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73205", "l": "D-glucose(in) + H(+)(out) => D-glucose(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023549", "l": "PTPN1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70140", "l": "6-deoxo-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-nortyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202325", "l": "Recruitment of Gads to LAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51176", "l": "cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17156", "l": "CDP-D-glucose <=> CDP-4-dehydro-6-deoxy-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052727", "l": "capsanthin synthase activity", "d": ["Catalysis of the reaction: antheraxanthin = capsanthin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16489", "l": "(R)-prunasin + H2O = D-glucose + mandelonitrile", "d": []}, {"i": "EC:3.2.1.118", "l": "\"prunasin beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38042", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428273", "l": "SPHK1 phosphorylates SPG to S1P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10520", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.241", "l": "\"digalactosyldiacylglycerol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16440", "l": "glutathione + RX <=> a halide anion + an S-substituted glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32267", "l": "4-aminobutanoate + glyoxylate = glycine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58213", "l": "ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] => dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70936", "l": "L-lysine(in) => L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047143", "l": "chlorate reductase activity", "d": ["Catalysis of the reaction: AH(2) + chlorate = A + chlorite + H2O + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21721", "l": "formamide => H2O + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11402", "l": "4'-O-demethylsordarin + GDP + H(+) => GDP-6-deoxy-alpha-D-altrose + sordaricin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199112", "l": "CRTAM binds to NECL2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050245", "l": "quercitrinase activity", "d": ["Catalysis of the reaction: H2O + quercitrin = L-rhamnose + quercetin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177479", "l": "Axonal transport of NGF:Trk complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56060", "l": "H(+) + hexadecanoate + hnu = CO2 + pentadecane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102598", "l": "3alpha-hydroxy-ent-sandaracopimardiene 7-beta-monooxygenase activity", "d": ["Catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 <=> oryzalexin D + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24606", "l": "H(+) + S-adenosyl-L-homocysteine + theobromine => 7-methylxanthine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004336", "l": "galactosylceramidase activity", "d": ["Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.3.4", "l": "\"NADH oxidase (H2O-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28996", "l": "H(+)(out) + L-threonine(in) => H(+)(in) + L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990308", "l": "type-I dockerin domain binding", "d": ["Binding to a type-I dockerin domain of a protein. Type-I dockerin domain is the binding partner of type-1 cohesin domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52141", "l": "a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O => a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983519", "l": "IL35 binds IL12RB2:IL12RB2 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14128", "l": "2 raffinose <=> 1(F)-alpha-D-galactosylraffinose + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53346", "l": "H(+) + NADPH + uridine(20a) in tRNA => 5,6-dihydrouridine(20a) in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514865", "l": "cGMP dissociates from CNG channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46600", "l": "[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11601", "l": "ATP + CMP => ADP + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106420", "l": "NAD-dependent protein biotinidase activity", "d": ["Catalysis of the reaction: H2O + N6-biotinyl-L-lysyl-[protein] + NAD+ = 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:70479", "l": "H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+) = 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.20", "l": "\"beta-Ala-His dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218852", "l": "p-6Y-VEGFR2 binds PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685011", "l": "ATR activation at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45288", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 = 2-glyceryl-prostaglandin G2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10611", "l": "(E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase] <=> (E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.44", "l": "\"nuclear-inclusion-a endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36208", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68020", "l": "(2E)-geranyl phosphate + H2O = (2E)-geraniol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004792", "l": "thiosulfate sulfurtransferase activity", "d": ["Catalysis of the reaction: hydrogen cyanide + thiosulfate = H+ + sulfite + thiocyanate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58479", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine <=> a 1-acyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-168400", "l": "iE-DAP elicits a NOD1 response (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52669", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate => [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74254", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202692", "l": "PIP3 binds to RhoA and activates it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63895", "l": "ATP + H2O + L-tryptophan <=> AMP + D-tryptophan + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009282", "l": "CDK1 phosphorylates RUNX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12496", "l": "2 Fe(2+) + 4 H2O + O2 = 6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9705584", "l": "HMGCR dimer binds statins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66184", "l": "3',5'-cyclic AMP(in) + ATP + H2O = 3',5'-cyclic AMP(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67246", "l": "2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH => 3-deoxyglucosone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54537", "l": "a very long-chain fatty acid + ATP + CoA => a very long-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982810", "l": "JAK2 phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2203516", "l": "Alpha-1-Microglobulin is cleaved (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14739", "l": "3',5'-cyclic CMP + diphosphate => CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46279", "l": "(S)-malate + H(+) <=> (S)-lactate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36467", "l": "H2O + L-alanylglycine = glycine + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19041", "l": "(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] = (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28345", "l": "dITP + H2O <=> dIMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19231", "l": "an aromatic carboxylate + ATP + H(+) + NADPH => AMP + an aromatic aldehyde + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38364", "l": "1-octadecanoylglycerol + H2O => glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863494", "l": "ASICs bind STOML3, (STOM) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3791319", "l": "NID1 degradation by MMP19 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67718", "l": "H(+) + NADP(+) + 2 reduced [2Fe-2S]-[protein] => NADPH + 2 oxidized [2Fe-2S]-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56066", "l": "3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629918", "l": "NEIL1 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202233", "l": "Inactivation of Lck by Csk (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649733", "l": "mature p21 RAS binds GDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12498", "l": "6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide => 2 Fe(2+) + 4 H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797961", "l": "CHDH oxidises Cho to BETALD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44172", "l": "H2O + NAD(+) + tetradecanal = 2 H(+) + NADH + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57334", "l": "3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite => H2O + 3 O2 + 3 propionate 3-nitronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28080", "l": "H(+) + NADH + phosphonoacetaldehyde => 2-hydroxyethylphosphonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948034", "l": "FGR binds LDL:LRP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54653", "l": "peregrinol diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48142", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite => 2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050395", "l": "vitexin beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-glucose + vitexin = H+ + UDP + vitexin 2''-O-beta-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428273", "l": "SPHK1 phosphorylates SPG to S1P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48419", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)) <=> CMP + ganglioside GM2 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047955", "l": "glycerol dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: A + glycerol = AH(2) + glycerone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42281", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177934", "l": "EGFR autophosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5633051", "l": "EFCAB7:IQCE binds EVC2:EVC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69465", "l": "2 [thioredoxin]-dithiol + arsenic triglutathione + H2O + 2 S-adenosyl-L-methionine => 2 [thioredoxin]-disulfide + dimethylarsinous acid + 3 glutathione + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22652", "l": "2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O = 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate", "d": []}, {"i": "EC:3.1.3.69", "l": "\"glucosylglycerol 3-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22266", "l": "3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O => 3,5,6-trichloropyridin-2-ol + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111966", "l": "GRK2 binds CALM1:4Ca2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16314", "l": "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O => 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11853", "l": "phosphate + S-methyl-5'-thioadenosine => adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632871", "l": "Defective SLC2A10 does not transport Glc from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797271", "l": "Expression of MAOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27329", "l": "H(+) + NADH + O2 + urate = 5-hydroxyisourate + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.113", "l": "\"FAD-dependent urate hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8979071", "l": "KDM6B binds iron (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877153", "l": "STARD7 binds PC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685607", "l": "Sialic acid binds SIGLEC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0061578", "l": "K63-linked deubiquitinase activity", "d": ["Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys63 residue of ubiquitin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66917", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40682", "l": "(9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate <=> 1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043914", "l": "NADPH:sulfur oxidoreductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + sulfur = hydrogen sulfide + NADP+."]}, {"i": "EC:1.8.1.18", "l": "\"NAD(P)H sulfur oxidoreductase (CoA-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928639", "l": "p-EFNB binds GRB4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033888", "l": "chondro-6-sulfatase activity", "d": ["Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44768", "l": "3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) = 2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57761", "l": "2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH => C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534096", "l": "METAP1/2 demethylates GNAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9761474", "l": "AMOT-2 binds CDH11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17557", "l": "anthranilate + malonyl-CoA = CoA + N-malonylanthranilate", "d": []}, {"i": "EC:2.3.1.113", "l": "\"anthranilate N-malonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17746", "l": "N-acetyl-D-glucosamine + UDP-alpha-D-galactose => beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23249", "l": "myo-inositol + S-adenosyl-L-methionine => 1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39563", "l": "(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH = (23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58104", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186786", "l": "Autophosphorylation of PDGF beta receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61854", "l": "campesteryl 3-beta-D-glucoside + H(+) + UDP => campesterol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62008", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48015", "l": "4-methyl-5-nitrocatechol + NADPH + O2 <=> 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033912", "l": "2,6-beta-fructan 6-levanbiohydrolase activity", "d": ["Catalysis of the hydrolysis of (2->6)-beta-D-fructofuranan, to remove successive disaccharide residues as levanbiose, i.e. 6-(beta-D-fructofuranosyl)-D-fructose, from the end of the chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975852", "l": "IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61259", "l": "H2O + L-cysteine + O2 <=> 2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674022", "l": "BRAP autoubiquitinates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047379", "l": "ADP-dependent short-chain-acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: H2O + a short-chain acyl-CoA = a short-chain carboxylate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20513", "l": "2-aryl-2-methylmalonate + H(+) = 2-arylpropionate + CO2", "d": []}, {"i": "EC:4.1.1.76", "l": "\"arylmalonate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052886", "l": "9,9'-dicis-carotene:quinone oxidoreductase activity", "d": ["Catalysis of the reaction: 9,9'-di-cis-zeta-carotene + a quinone = 7,9,9'-tri-cis-neurosporene + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15682", "l": "2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) => (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733781", "l": "EOMES, WDR5, KAT2A, and TBXT bind the MESP1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210274", "l": "SIRP beta binds TYROBP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12957", "l": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+)", "d": []}, {"i": "EC:3.1.1.6", "l": "\"acetylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42101", "l": "ATP + carbamoyl phosphate + H2O + kanamycin A => 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30490", "l": "H(+) + N,N-dihydroxy-L-isoleucine <=> (1E,2S)-2-methylbutanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875661", "l": "GGA3 associates with activated MET receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002460", "l": "P4HB binds Collagen chains (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72663", "l": "De novo formation of eIF2:GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14410", "l": "cysteamine + O2 => H(+) + hypotaurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53202", "l": "17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874979", "l": "ACBD3 binds GOLGB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981931", "l": "RAC1 and CDC42 activate PAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24419", "l": "2,4'-dihydroxyacetophenone + O2 <=> 4-hydroxybenzoate + formate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45029", "l": "(2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35685", "l": "3-oxohexadecasphinganine + H(+) + NADPH => hexadecasphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67601", "l": "H2O + O(6)-methyl-dGTP => diphosphate + H(+) + O(6)-methyl-dGMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873919", "l": "Phosphorylation of JAK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237129", "l": "Acireductone is created (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10651", "l": "2-hydroxycyclohexan-1-one + H(+) + NADPH + O2 <=> 6-hydroxyhexan-6-olide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61264", "l": "H2O + L-alanine + O2 = H2O2 + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63477", "l": "NADP(+) + prostaglandin E2 => 15-oxoprostaglandin E2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74365", "l": "coproporphyrin III(in) => coproporphyrin III(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561072", "l": "OCT3 mediates renal uptake of organic cations (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71912", "l": "cholate(out) + 2 Na(+)(out) => cholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31394", "l": "15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) <=> all-trans-4,4'-diapolycopene + 4 FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444047", "l": "Receptor FFAR3 binds carboxylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.958976004066542", "identifiers": [{"i": "GO:0008237", "l": "metallopeptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41176", "l": "Co(I)-[dimethylamine-specific corrinoid protein] + dimethylamine + H(+) => methyl-Co(III)-[dimethylamine-specific corrinoid protein] + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416690", "l": "SEMA4A binds to PLXND1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68859", "l": "(2Z,6E)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33649", "l": "(9Z)-hexadecenoyl-CoA + AMP + diphosphate => (9Z)-hexadecenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004921", "l": "interleukin-11 receptor activity", "d": ["Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55371", "l": "(R)-carnitine + H(+) + NADPH + O2 <=> (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59068", "l": "demethyldeoxyspectinabilin + S-adenosyl-L-methionine = deoxyspectinabilin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46479", "l": "4alpha-hydroxymethylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formylzymosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49371", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) <=> 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14912", "l": "L-gulonate + NADP(+) <=> aldehydo-D-glucuronate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863727", "l": "STON2 is neddylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69279", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate <=> but-3-enenitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5632677", "l": "PTCH is internalized (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690152", "l": "USP5 cleaves polyubiquitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48233", "l": "acetyl-CoA + L-glutamate 5-semialdehyde => CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39783", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27277", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.47", "l": "\"alpha-santonin 1,2-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357828", "l": "RIPK1 is cleaved by CASP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65808", "l": "decanoyl-[ACP] + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = dec-9-ynoyl-[ACP] + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.78", "l": "\"decanoyl-[acyl-carrier protein] acetylenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17338", "l": "catechol + O2 => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49795", "l": "eicosanoyl-CoA + glycine <=> CoA + H(+) + N-eicosanoylglycinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36708", "l": "O-ureido-L-serine => O-ureido-D-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033920", "l": "6-phospho-beta-galactosidase activity", "d": ["Catalysis of the reaction: a 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004936", "l": "alpha-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047215", "l": "indole-3-acetate beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: (indol-3-yl)acetate + UDP-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45196", "l": "5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein] = 5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": []}, {"i": "EC:2.1.1.245", "l": "\"5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351208", "l": "Spermidine  => N-acetylated spermidine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810139", "l": "HOXA2 chromatin is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451942", "l": "Within the IL-2R complex JAK3 phosphorylates JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44551", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30624", "l": "A + all-trans-neurosporene => AH2 + all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804596", "l": "APAF1:CYCS binds APIP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2172433", "l": "Collagen type XIX degradation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26459", "l": "ethylnitronate + FMNH2 + O2 => acetaldehyde + FMN + 2 H(+) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029468", "l": "Conversion of PA into DAG by PAP-1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43113", "l": "(R)-mandelate + NAD(+) => H(+) + NADH + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21893", "l": "D-arabinose + NADP(+) => D-arabinono-1,4-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31465", "l": "beta-D-glucosyl crocetin + UDP => crocetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20203", "l": "AMP + D-phenylalanine + diphosphate + H(+) => ATP + H2O + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-517705", "l": "p-S318,221-HuR binds mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793978", "l": "Expression of STAT6-upregulated extracellular proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602458", "l": "Activation of proMMP10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16553", "l": "aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] = H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994034", "l": "Expression of Interferon-alpha and beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47009", "l": "[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide => [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944246", "l": "Association of procollagen type XXI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44282", "l": "4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263444", "l": "Defective SGSH does not hydrolyse Heparan sulfate chain(7) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1878002", "l": "XYLTs transfer Xyl to core protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56267", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26245", "l": "geranylgeranyl diphosphate = diphosphate + fusicocca-2,10(14)-diene", "d": []}, {"i": "EC:4.2.3.43", "l": "\"fusicocca-2,10(14)-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38663", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033938", "l": "1,6-alpha-L-fucosidase activity", "d": ["Catalysis of the hydrolysis of (1->6) linkages between alpha-L-fucose and N-acetyl-D-glucosamine in glycopeptides such as immunoglobulin G glycopeptide and fucosyl-asialo-agalacto-fetuin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9760402", "l": "ILF3 binds HOXC8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236970", "l": "Proteasomal clevage of exogenous antigen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38693", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43850", "l": "[thioredoxin]-disulfide + arsenite + H2O => [thioredoxin]-dithiol + arsenate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-420688", "l": "GABAB heterodimeric receptor binds GABA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56458", "l": "12-epi-fischerindole U => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102038", "l": "4-nitrobenzyl alcohol oxidase activity", "d": ["Catalysis of the reaction: 4-nitrobenzyl alcohol + O2 <=> 4-nitrobenzaldehyde + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380782", "l": "STAT binds to the active receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31649", "l": "5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate => beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618785", "l": "Calmodulin binds neurogranin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53327", "l": "2-glyceryl-prostaglandin H2 <=> 2-glyceryl-prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38108", "l": "2-dehydro-3-deoxy-L-galactonate => L-glyceraldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70897", "l": "H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein] => N-terminal L-cysteinyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62726", "l": "(+)-isomalbrancheamide C + FADH2 => (+)-premalbrancheamide + bromide + FAD + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102585", "l": "cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside malonyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + malonyl-CoA + H+ <=> cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000823", "l": "inositol-1,4,5-trisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48291", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM3 <=> CMP + ganglioside GD3 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58780", "l": "a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine = a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36734", "l": "1-nitrocyclohexan + NADP(+) <=> 1-nitrocyclohexene + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943728", "l": "SALL4 binds the PTEN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54145", "l": "2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 => 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10487", "l": "H2O + N-feruloylglycine <=> (E)-ferulate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983153", "l": "E1 mediated ubiquitin activation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624272", "l": "MMPs cleave HB-EGF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9769235", "l": "MAGED1 binds NPAS4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75592", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (11S)-hydroxy-(9S,10S)-epoxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035276", "l": "ethanol binding", "d": ["Binding to ethanol, CH(3)-CH(2)-OH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65767", "l": "a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + H2O <=> (2E,4S)-4,5-dihydroxypent-2-enal + a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986294", "l": "RUNX2 binds GLI2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52712", "l": "dTMP + H2O = 2-deoxy-D-ribose 5-phosphate + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72199", "l": "Ca(2+)(in) + 2 H(+)(out) = Ca(2+)(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199043", "l": "LILRs interact with MHC Class I (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69015", "l": "5beta-dihydrotestosterone + H(+) + NADPH <=> 5beta-androstane-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168046", "l": "Collagen type XII degradation by MMP12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-984689", "l": "Kinesin-7 is a dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17414", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38119", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132247", "l": "CD59 binds C5b:C6:C7:C8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59638", "l": "D-xylotriono-1,5-lactone + H2O2 => D-xylotriose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68536", "l": "(2E,6E)-farnesyl diphosphate = (-)-alpha-cedrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-532603", "l": "Nephrin mediated activation of N-WASP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57204", "l": "glyoxal + L-lysyl-[protein] = N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64462", "l": "H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate => acetyl phosphate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070053", "l": "thrombospondin receptor activity", "d": ["Combining with thrombospondin and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60113", "l": "(R)-3-(indol-3-yl)lactoyl-CoA => (E)-3-(indol-3-yl)acryloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24576", "l": "diphosphate + H2O = H(+) + 2 phosphate", "d": []}, {"i": "EC:3.6.1.1", "l": "\"inorganic diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429101", "l": "HMIT co-transports myo-inositol with a proton (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65680", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31159", "l": "(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912627", "l": "CBL ubiquitinates PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24517", "l": "acetyl-CoA + gentamicin C1a => CoA + H(+) + N(2')-acetylgentamicin C1a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43655", "l": "decanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxododecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67151", "l": "L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2 <=> 2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036384", "l": "CDP phosphatase activity", "d": ["Catalysis of the reaction: CDP + H2O = CMP + phosphate."]}, {"i": "RHEA:64880", "l": "CDP + H2O = CMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26346", "l": "L-galactonate + NADP(+) => aldehydo-D-galacturonate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41713", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730882", "l": "Phosphorylation of PKC-theta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59573", "l": "H2O + L-homocarnosine => 4-aminobutanoate + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15451", "l": "4-maleylacetoacetate + H(+) => homogentisate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623051", "l": "Defective RHAG does not transport NH4+ from cytosol to extracellular region (rbc) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434097", "l": "viral dsRNA:TRL3:TICAM1 activates RIP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538904", "l": "Phosphorylated PER binds to CLK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697008", "l": "CREBBP acetylates histone H2B, H3, H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44238", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102697", "l": "trans-zeatin-O-glucoside UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + O-beta-D-glucosyl-trans-zeatin = H+ + trans-zeatin-O-glucoside-7-N-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15977", "l": "(S)-4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrogen cyanide", "d": []}, {"i": "EC:4.1.2.11", "l": "\"hydroxymandelonitrile lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684836", "l": "CLEC1B dimer binds PDPN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120021", "l": "oxysterol transfer activity", "d": ["Removes oxysterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46828", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75790", "l": "GTP(in) <=> GTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46099", "l": "3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + dihydropinosylvin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60153", "l": "gamma-L-glutamyl-L-glutamyl-[protein] + H2O => L-glutamate + L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507875", "l": "Aquaporins passively transport urea into cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676596", "l": "TRAF3 binds BAFFR:BAFF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-606287", "l": "RSF complex binds the centromere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40312", "l": "hexanoyl-CoA + O2 => (2E)-hexenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15721", "l": "glycine + H2O + NAD(+) = glyoxylate + H(+) + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.10", "l": "\"glycine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64529", "l": "AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine => 2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10253", "l": "H(+) + hydrogen sulfide + O-phospho-L-serine => L-cysteine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9007447", "l": "E2F6 forms the PRC1L4 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623280", "l": "PCK1 gene expression is stimulated by FOXO1:PPARGC1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682388", "l": "Autophagosome maturation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351936", "l": "Caspase-mediated cleavage of claspin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20632", "l": "H2O + O-phospho-L-seryl-[protein] <=> L-seryl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603407", "l": "Activated NTRK3 binds PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28210", "l": "H2O + L-saccharopine + O2 = (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate", "d": []}, {"i": "EC:1.5.3.18", "l": "\"L-saccharopine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67249", "l": "(E)-4-hydroxynon-2-enal + H2O + NAD(+) => (E)-4-hydroxynon-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429101", "l": "HMIT co-transports myo-inositol with a proton (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047059", "l": "polyvinyl alcohol dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: polyvinyl alcohol + ferricytochrome c = oxidized polyvinyl alcohol + ferrocytochrome c + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102310", "l": "dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate 3-ketoreductase (dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose-forming) activity", "d": ["Catalysis of the reaction: dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose + NAD(P) <=> dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate + 2 H+ + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60656", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110218", "l": "Cleavage of uracil by TDG glycosylase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2282889", "l": "Defective ARSB does not hydrolyse C4S/C6S chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47010", "l": "[DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite => [DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169398", "l": "ISGylation of host protein filamin B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37163", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64914", "l": "a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate => a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30343", "l": "FAD + H(+) + succinate = FADH2 + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005135", "l": "interleukin-3 receptor binding", "d": ["Binding to an interleukin-3 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14649", "l": "demethyllactenocin + dTDP-beta-L-mycarose = demethylmacrocin + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.318", "l": "\"demethyllactenocin mycarosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22648", "l": "holo-[cytochrome c] = apo-[cytochrome c] + heme b", "d": []}, {"i": "EC:4.4.1.17", "l": "\"holocytochrome-c synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.071082486141265", "identifiers": [{"i": "GO:0008081", "l": "phosphoric diester hydrolase activity", "d": ["Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48383", "l": "alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9677051", "l": "Formation of the PCAF-ATAC complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66569", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O => preluffariellolide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871227", "l": "RET binds GFRA4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983707", "l": "SYK autophosphorylates at the activated BCR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27469", "l": "H2O + N,N'-diacetylchitobiose = acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine", "d": []}, {"i": "EC:3.5.1.105", "l": "\"chitin disaccharide deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044377", "l": "RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending", "d": ["Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42185", "l": "5alpha-androstane-3beta,17beta-diol + NAD(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59030", "l": "4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => (Z)-24-ethylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977371", "l": "Factor I inactivates Factor H-boundC3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39747", "l": "cholesterol(in) = cholesterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654167", "l": "Activated FGFR1 binds PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28861", "l": "Ag(+)(out) + H(+)(out) => Ag(+)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60768", "l": "3 2-oxoglutarate + gibberellin A12 + 3 O2 = 3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806974", "l": "MET dimers autophosphorylate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0000146", "l": "microfilament motor activity", "d": ["A motor activity that generates movement along a microfilament, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36571", "l": "sphinganine + tetradecanoyl-CoA = CoA + H(+) + N-(tetradecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29713", "l": "cadaverine(out) + H(+)(out) => cadaverine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51217", "l": "3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one => adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210285", "l": "Trans-homophilic interaction of PECAM-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28213", "l": "H2O + L-saccharopine + O2 <=> (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062083", "l": "HLA-G specific inhibitory MHC class Ib receptor activity", "d": ["Combining with a MHC class Ib molecule of the HLA-G subclass to mediate signaling that inhibits activation of a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36082", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2314686", "l": "ASA- acetylates PTGS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33089", "l": "1,4-dihydroxy-6-naphthoate + chemical entity => cyclic dehypoxanthinylfutalosinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016401", "l": "palmitoyl-CoA oxidase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19013", "l": "dTTP + H2O = dTDP + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.39", "l": "\"thymidine-triphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375140", "l": "CDO binds promyogenic cadherins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52749", "l": "alpha-isomaltosyl-(1->3)-isomaltose + H2O => 2 isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34491", "l": "H2O + UDP-N,N'-diacetylbacillosamine = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009002", "l": "serine-type D-Ala-D-Ala carboxypeptidase activity", "d": ["Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807106", "l": "PTEN undergoes monoubiquitination (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64802", "l": "(4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+) => NAD(+) + S-(2-aminoethyl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55797", "l": "H(+) + NADH + O2 + phenol => H2O + hydroquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47748", "l": "a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+)", "d": []}, {"i": "EC:7.2.1.1", "l": "\"NADH:ubiquinone reductase (Na(+)-transporting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50769", "l": "4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine => anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39156", "l": "(3R)-hydroxyoctadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0003724", "l": "RNA helicase activity", "d": ["Unwinding of an RNA helix, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26068", "l": "3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O = CoA + H(+) + phosphinomethylmalate", "d": []}, {"i": "EC:2.3.3.18", "l": "\"2-phosphinomethylmalate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53348", "l": "5,6-dihydrouridine(20a) in tRNA + NAD(+) = H(+) + NADH + uridine(20a) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297354", "l": "Acrosin Cleavage (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32334", "l": "(1S,2S,4R)-endo-fenchol + NAD(+) <=> (1S,4R)-fenchone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37227", "l": "(E,E)-sorbate + H(+) = (E)-1,3-pentadiene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160044", "l": "sulfate:chloride antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(in) + sulfate(out) = chloride(out) + sulfate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35528", "l": "H(+) + N-ethylmaleimide + NADH => N-ethylsuccinimide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29958", "l": "H(+)(in) + thymidine(in) <=> H(+)(out) + thymidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804402", "l": "TP53 binds POU4F1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190260", "l": "FGFR2b binds to FGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71567", "l": "5-phosphomethyl-dUMP in DNA + L-serine = 5-O-(L-seryl)-dTMP in DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090584", "l": "protein-phosphocysteine-galactitol-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + galactitol(out) = protein cysteine + galactitol-6-phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390641", "l": "ADRA1A,B,D bind ADR,NAd (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52111", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA <=> 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16188", "l": "an aldehyde + H2O + NAD(+) <=> a carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.958976004066542", "identifiers": [{"i": "GO:0008422", "l": "beta-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18954", "l": "L-erythro-7,8-dihydrobiopterin + NADP(+) => H(+) + NADPH + sepiapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59651", "l": "D-xylotriono-1,5-lactone + H2O <=> D-xylotrionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46472", "l": "4alpha-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61942", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75356", "l": "H2O + L-mimosine => 3-hydroxy-4H-pyrid-4-one + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507868", "l": "Aquaporins passively transport water into cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45978", "l": "9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+) => 3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19274", "l": "H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate => N-acetylneuraminate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36890", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39761", "l": "19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632892", "l": "TP53 stimulates transcription of RRM2B gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37938", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936462", "l": "PIN1 mediated IRF3 degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.535054500181104", "identifiers": [{"i": "GO:0030695", "l": "GTPase regulator activity", "d": ["Binds to and modulates the activity of a GTPase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47131", "l": "ATP + CoA + deoxycholate <=> AMP + deoxycholoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1227964", "l": "ERBB2 homodimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392870", "l": "Gs activation by prostacyclin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199046", "l": "Ligands bind L-selectin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.71", "l": "\"pancreatic elastase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.39", "l": "\"glucan endo-1,3-beta-D-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9620103", "l": "ALDH2 transforms GTN to NO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63074", "l": "4 CO2 + 4 CoA + orcinol => acetyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29718", "l": "2-hydroxyethane-1-sulfonate + FMNH2 + O2 <=> FMN + glycolaldehyde + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047587", "l": "5-alpha-hydroxysteroid dehydratase activity", "d": ["Catalysis of the reaction: 5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809785", "l": "MTMR2 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611721", "l": "β1-agonists bind ADRB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109858", "l": "MAP2K2 binds MAPK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034795", "l": "cyclohexane monooxygenase activity", "d": ["Catalysis of the reaction: cyclohexane + O2 + NAD(P)H + H+ = cyclohexanol + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050306", "l": "sucrose 1F-fructosyltransferase activity", "d": ["Catalysis of the reaction: 2 sucrose = D-glucose + 1F-beta-D-fructosylsucrose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382054", "l": "PDGF binds to extracellular matrix proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20765", "l": "(S)-methylmalonyl-CoA + pyruvate => oxaloacetate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446694", "l": "IRAK4 phosphorylates IRAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202960", "l": "Caspase mediated cleavage of C-IAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15732", "l": "D-mannonate + NAD(+) <=> H(+) + keto-D-fructuronate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38717", "l": "ADP + choline(in) + H(+) + phosphate => ATP + choline(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33577", "l": "a mannosylinositol-1-phosphophytoceramide + H2O => an inositol-1-phosphophytoceramide + beta-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55872", "l": "anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH", "d": []}, {"i": "EC:1.7.1.17", "l": "\"FMN-dependent NADH-azoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046556", "l": "alpha-L-arabinofuranosidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341294", "l": "Superoxide reduces cytochrome c (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417896", "l": "P2Y6 receptor can bind to UDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46347", "l": "propanoyl-CoA + tetradecanoyl-CoA <=> 3-oxo-2-methylhexadecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20348", "l": "[thioredoxin]-dithiol + NADP(+) <=> [thioredoxin]-disulfide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3791319", "l": "NID1 degradation by MMP19 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63290", "l": "9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444047", "l": "Receptor FFAR3 binds carboxylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9718360", "l": "GNRHR binds GNRHR peptide agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44259", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873926", "l": "IFNG dimer binds IFNGR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605723", "l": "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75032", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 9-hydroxy-octadecanoate => (9Z-octadecenoyl)-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24145", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA => 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9641111", "l": "Parkin transfers Ub to misfolded proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265456", "l": "NPC1L1 binds ezetimibe (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865693", "l": "BRWD1 gene expression is repressed by STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53299", "l": "(2E)-decenoyl-CoA + NADP(+) <=> (2E,4E)-decadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879266", "l": "mycothiol is oxidized to mycothione (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688834", "l": "ATXN3 binds VCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.375", "l": "\"L-2-hydroxycarboxylate dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59622", "l": "4-aminobutanoate + L-lysine => H2O + N(2)-(4-aminobutanoyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612534", "l": "Expression of ID2 and ID4 is repressed by EGR2:NAB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74867", "l": "(E)-caffeyl aldehyde + CoA + NADP(+) = (E)-caffeoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16229", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate", "d": []}, {"i": "EC:2.7.7.41", "l": "\"phosphatidate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390593", "l": "ATP Hydrolysis By Myosin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.688704758796746", "identifiers": [{"i": "GO:0008408", "l": "3'-5' exonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end."]}, {"i": "REACT:R-HSA-3245943", "l": "Viral DNA cleavage by TREX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070335", "l": "aspartate binding", "d": ["Binding to aspartate, the alpha-amino-acid anion of 2-aminobutanedioic acid that has formula C4H5NO4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70880", "l": "L-glutamine(in) + L-threonine(out) + Na(+)(out) => L-glutamine(out) + L-threonine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034020", "l": "neoxanthin synthase activity", "d": ["Catalysis of the reaction: all-trans-violaxanthin = all-trans-neoxanthin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:1990042", "l": "glycerol dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which glycerol is converted into glycerone and NAD+ or NADP is reduced."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009026", "l": "tagaturonate reductase activity", "d": ["Catalysis of the reaction: D-altronate + NAD+ = D-tagaturonate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23539", "l": "alpha-D-glucose 1-phosphate <=> alpha-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60752", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone = CoA + jasmolin I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852362", "l": "GTSE1 binds CDKN1A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37304", "l": "ATP + glycyl-L-asparagine(out) + H2O => ADP + glycyl-L-asparagine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20636", "l": "a (3R)-hydroxyacyl-[ACP] + L-ornithine <=> a lyso-ornithine lipid + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70997", "l": "L-cystine(in) + L-glutamate(out) => L-cystine(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653886", "l": "B4GALT1 binds LALBA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68761", "l": "3 (R)-3-phenyllactate + (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022C + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199144", "l": "Nectin 2 binds CD226 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33218", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate <=> all-trans-heptaprenyl diphosphate + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102297", "l": "selenate adenylyltransferase activity", "d": ["Catalysis of the reaction: selenic acid + ATP + 2 H+ <=> adenylyl selenate + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36527", "l": "(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA = (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102814", "l": "caffeoyl-CoA:delphinidin-3,5,3'-triglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: delphinidin 3,3',5-tri-O-beta-D-glucoside betaine + caffeoyl-CoA <=> delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0031490", "l": "chromatin DNA binding", "d": ["Binding to DNA that is assembled into chromatin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687088", "l": "PKA phosphorylates MAPKAPK5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4717406", "l": "Defective DPM1 does not transfer mannose to DOLP to form DOLPman (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28950", "l": "H(+)(out) + L-arabinose(in) <=> H(+)(in) + L-arabinose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102955", "l": "S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity", "d": ["Catalysis of the reaction: 2-demethylmenaquinol-7 + S-adenosyl-L-methionine = menaquinol-7 + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666428", "l": "DOCK180 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671737", "l": "p-T774-PKN1 binds CDC25C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62639", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide <=> (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450494", "l": "HuR binds mRNAs in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002055", "l": "adenine binding", "d": ["Binding to adenine, a purine base."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43980", "l": "H(+) + hexadecanoate + NADPH + O2 = 15-hydroxyhexadecanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30406", "l": "Fe(3+)(out) + L-ascorbate(in) <=> Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940561", "l": "MMP7 cleaves OPTC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52499", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21316", "l": "H2O + phorbol 12,13-dibutanoate = butanoate + H(+) + phorbol 13-butanoate", "d": []}, {"i": "EC:3.1.1.51", "l": "\"phorbol-diester hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001093", "l": "TFIIB-class transcription factor binding", "d": ["Binding to a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684043", "l": "Defective ABCD1 does not transfer LCFAs from cytosol to peroxisomal matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13221", "l": "(R)-mevalonate + NAD(+) = H(+) + mevaldate + NADH", "d": []}, {"i": "EC:1.1.1.32", "l": "\"mevaldate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55936", "l": "all-trans-4-hydroxyretinol + NAD(+) = all-trans-4-hydroxyretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61838", "l": "ergosteryl 3-beta-D-glucoside + H(+) + UDP => ergosterol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62116", "l": "H2O + iminosuccinate = NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164513", "l": "3' PPT-primed initiation of plus-strand DNA synthesis  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679239", "l": "ULK complex translocates to the ER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2465940", "l": "atRAL is reduced to atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.30", "l": "\"caricain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27940", "l": "glycine + glyoxylate => (3R)-3-hydroxy-D-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662986", "l": "MT2A binds copper (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59679", "l": "D-maltotetraose + O2 <=> D-maltotetraono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708866", "l": "pro-F2R binds vorapaxar (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63220", "l": "7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine = 5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65901", "l": "3-hydroxy-L-kynurenine + glyoxylate => glycine + H2O + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45802", "l": "10-decarboxymethylaclacinomycin T + A + CO2 + H2O => 15-demethylaclacinomycin T + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61612", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 = 7-epi-cylindrospermopsin + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166538", "l": "The bound receptor dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61426", "l": "cis-cis-nepetalactone + H(+) + NADH => cis-cis-nepetalactol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14259", "l": "a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696274", "l": "RND1 binds GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-844438", "l": "NLRP1 oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15356", "l": "all-trans-violaxanthin + L-ascorbate <=> all-trans-antheraxanthin + H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-398040", "l": "Gbeta:gamma activation of PLC beta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32688", "l": "(2E)-geranyl diphosphate => diphosphate + tricyclene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420128", "l": "SRC-1 phosphorylates SHB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15694", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 => (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854981", "l": "SHC1 in the RET complex is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65010", "l": "decanoyl-AMP + diphosphate => ATP + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088130", "l": "PLK1 binds FOXM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805285", "l": "PLK3 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004369", "l": "glycerol-3-phosphate oxidase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + O2 = glycerone phosphate + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74812", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008999", "l": "peptide-alanine-alpha-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + N-terminal L-alanyl-peptide = CoA + H+ + N-terminal N-alpha-acetyl-L-alanyl-peptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672948", "l": "MARK3 phosphorylates KSR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24684", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH => 5,10-methylenetetrahydromethanopterin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785860", "l": "Expression of SOCS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050148", "l": "nucleotide diphosphokinase activity", "d": ["Catalysis of the reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54207", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 <=> 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202174", "l": "Activation of ZAP-70 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-532549", "l": "MPI isomerises Fru6P to Man6P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956676", "l": "YAP1 binds TP73 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12156", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) = 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH", "d": []}, {"i": "EC:1.1.1.398", "l": "\"2-glutathionyl-2-methylbut-3-en-1-ol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182594", "l": "Association of INK4 family proteins with CDK4/6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15413", "l": "(2R,3R)-tartrate = H2O + oxaloacetate", "d": []}, {"i": "EC:4.2.1.32", "l": "\"L(+)-tartrate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47036", "l": "uridine in 5S rRNA = pseudouridine in 5S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29746", "l": "2-phenylethylamine(in) <=> 2-phenylethylamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16377", "l": "(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.7.4", "l": "\"phytochromobilin:ferredoxin oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168886", "l": "Hemopexin binds Hemes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32436", "l": "dihydrocarvone + H(+) + NADPH + O2 => 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46827", "l": "4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28730", "l": "Cu(2+)(in) + H(+)(in) <=> Cu(2+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59689", "l": "D-maltoheptaose + O2 => D-maltoheptaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018493", "l": "formylmethanofuran dehydrogenase activity", "d": ["Catalysis of the reaction: N-formylmethanofuran + A + H2O + H+ = AH(2) + CO2 + methanofuran."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.98.1.-", "l": "\"Other oxidoreductases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018807", "l": "RAC3 GDIs block activation of RAC3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380311", "l": "Recruitment of Plk1 to centrosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5681987", "l": "LC3 is cleaved by ATG4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49789", "l": "chenodeoxycholoyl-CoA + glycine => CoA + glycochenodeoxycholate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72521", "l": "6-hydroxyphenazine-1-carboxylate + CO2 + H2O + NAD(+) => 2 H(+) + NADH + O2 + phenazine-1,6-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37546", "l": "2-amino-5-chlorophenol + O2 <=> 2-amino-5-chloromuconate 6-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13939", "l": "3,4-dihydroxybenzoate + NAD(+) + sulfite => 4-sulfobenzoate + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29502", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-alpha-barbatene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30703", "l": "H(+) + salicylate = CO2 + phenol", "d": []}, {"i": "EC:4.1.1.91", "l": "\"salicylate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74568", "l": "L-glutamate(in) + N-acetyl-L-cysteine(out) => L-glutamate(out) + N-acetyl-L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24478", "l": "H(+) + maleamate => H2O + maleimide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49001", "l": "aurachin C + H(+) + NADH + O2 => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62706", "l": "2,3-didehydrophenylalanine + glycine => glycyldehydrophenylalanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10354", "l": "acetate + an aralkylamine => an N-acetylarylalkylamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993802", "l": "HLCS biotinylates PC:Mn2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65375", "l": "CMP-N-acetyl-beta-neuraminate + globoside GalGb4Cer <=> CMP + globoside MSGG + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12938", "l": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004458", "l": "D-lactate dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71302", "l": "chloride(out) + L-isoleucine(out) + 2 Na(+)(out) <=> chloride(in) + L-isoleucine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982617", "l": "CYGB:O2 dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635845", "l": "GLI proteins bind CDC73 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45355", "l": "9,10-epoxyoctadecanoate + H2O <=> 9,10-dihydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204813", "l": "Interaction of Tie2 and Grb14 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17177", "l": "(R)-carnitine + octanoyl-CoA = CoA + O-octanoyl-(R)-carnitine", "d": []}, {"i": "EC:2.3.1.137", "l": "\"carnitine O-octanoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38931", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9736953", "l": "FURIN translocates to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10955", "l": "(E)-sinapoyl-CoA + hydroxymalonate <=> (E)-sinapoyltartronate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425861", "l": "Activation of Protein Kinase C novel isoforms (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71295", "l": "chloride(out) + 2 Na(+)(out) + O-propanoyl-(R)-carnitine(out) = chloride(in) + 2 Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671772", "l": "p-T38-PPP1R14A binds MLCP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41627", "l": "3-sulfinopropanoyl-CoA + H2O <=> H(+) + propanoyl-CoA + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944255", "l": "Association of procollagen type VII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10137", "l": "2 glyoxylate + H(+) => 2-hydroxy-3-oxopropanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36577", "l": "CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine => (9Z)-octadecenoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917700", "l": "MVB Vesicle Formation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852331", "l": "GTSE1 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24445", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68574", "l": "L-tyrosine(out) => L-tyrosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202534", "l": "Ubiquitination of NEMO by TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9677050", "l": "Formation of the GCN5-ATAC complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64570", "l": "ilicicolin H => 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19131", "l": "ADP + dTMP + H(+) => ATP + thymidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65792", "l": "fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004661", "l": "protein geranylgeranyltransferase activity", "d": ["Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16966", "l": "(2E)-geranyl diphosphate => beta-myrcene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38570", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047438", "l": "2-dehydro-3-deoxy-L-pentonate aldolase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-L-pentonate = glycolaldehyde + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018785", "l": "RHOBTB2 binds GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047345", "l": "ribose-5-phosphate adenylyltransferase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + ADP + H+ = ADP-ribose + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202709", "l": "JAM2 dimerises (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111237", "l": "Formation of ADAR1 homodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21425", "l": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) => 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45606", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) => D-glucaro-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47381", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052640", "l": "salicylic acid glucosyltransferase (glucoside-forming) activity", "d": ["Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid 2-O-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36631", "l": "D-ribulose 1,5-bisphosphate + O2 = (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20463", "l": "an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine => an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33777", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63930", "l": "an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102893", "l": "betanidin 6-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + betanidin <=> H+ + gomphrenin I + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821410", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982703", "l": "PKC binds active G alpha (z) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202443", "l": "Oligomerization of CARMA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13948", "l": "(S)-mandelate <=> (R)-mandelate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55325", "l": "11-cis-retinol + hexadecanoyl-CoA => 11-cis-retinyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72040", "l": "nicotinate(in) + orotate(out) => nicotinate(out) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018826", "l": "RHOT2 hydrolyzes GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166753", "l": "Conversion of C4 into C4a and C4b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0015205", "l": "nucleobase transmembrane transporter activity", "d": ["Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950183", "l": "IL12B binds IL23A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982765", "l": "Growth hormone forms dimers and oligomers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956608", "l": "MYB gene transcription is stimulated by the RUNX1-containing TAL1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2130706", "l": "MHC class II antigen processing (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-179410", "l": "Association of Nek2A with MCC:APC/C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58535", "l": "15alpha-stemmadenine intermediate I + H2O <=> akuammicine + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54848", "l": "H(+) + hexan-3-one + NADPH + O2 = H2O + NADP(+) + propyl propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71642", "l": "K(+)(in) + Na(+)(in) <=> K(+)(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-481010", "l": "Surface deployment of platelet dense granule membrane components (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419144", "l": "5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + ADP + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190829", "l": "Lysosomal degradation of gap junction plaques (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47782", "l": "a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in 25S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.6", "l": "\"leucolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004022", "l": "alcohol dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53312", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46542", "l": "a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381496", "l": "Formation of the IGF:IGFBP3:ALS complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21899", "l": "(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP <=> adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53455", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351901", "l": "Caspase-mediated cleavage of MST3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67522", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29324", "l": "fumarate(in) + succinate(out) => fumarate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-210444", "l": "L-Glutamate loading of synaptic vesicle (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35009", "l": "D-fucose(out) => D-fucose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624952", "l": "Assembly of the retrograde IFT train (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617828", "l": "TRIP11:IFT20 dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28527", "l": "(R)-carnitine + crotonobetainyl-CoA => (R)-carnitinyl-CoA + crotonobetaine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019141", "l": "2-dehydropantolactone reductase (B-specific) activity", "d": ["Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70758", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5140741", "l": "WNT5A binds FZD and ROR receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685607", "l": "Sialic acid binds SIGLEC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64172", "l": "L-altrarate = galactarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.10", "l": "\"oligo-1,6-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781899", "l": "USP13 binds SIAH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0009020", "l": "tRNA (guanosine-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.17.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67339", "l": "kaempferol 3-O-beta-D-glucoside + malonyl-CoA <=> CoA + kaempferol 3-O-(6-O-malonyl-beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57413", "l": "AMP + diphosphate + L-tyrosinal + NADP(+) => ATP + H(+) + L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606789", "l": "ARSB hydrolyses DS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70653", "l": "H(+) + holo-[ACP] + N(6)-[(9Z)-hexadecenoyl]-L-lysyl-[protein] => (9Z)-hexadecenoyl-[ACP] + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5221061", "l": "TDG excises 5-carboxylcytosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768930", "l": "NPAS4 binds MDM2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641229", "l": "TLE oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682603", "l": "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909729", "l": "Activation of JAK kinases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474210", "l": "Collagen type III degradation by MMP14 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791083", "l": "Expression of Sec12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72768", "l": "acetyl-CoA + 9 H(+) + 4 malonyl-CoA + 5 NADPH => 7-methylmellein + 3 CO2 + 5 CoA + 4 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211924", "l": "CYP4B1 12-hydroxylates ARA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788867", "l": "FN3K phosphorylates ketosamines (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67439", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693198", "l": "RHOD binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69030", "l": "5beta-androstane-3alpha,17beta-diol + NADP(+) => 5beta-dihydrotestosterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20282", "l": "(Z)-desulfoglucotropeolin + 3'-phosphoadenylyl sulfate => (Z)-glucotropeolin + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976563", "l": "NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2872463", "l": "SLC9C1 exchanges Na+ for H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12229", "l": "ATP + H2O + L-aspartate + L-glutamine => AMP + diphosphate + H(+) + L-asparagine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678327", "l": "MIOX oxidises Ins to GlcA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53789", "l": "allodeoxycholoyl-CoA + beta-muricholate => allodeoxycholate + beta-muricholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10072", "l": "N,N-dimethylglycine + S-adenosyl-L-methionine = glycine betaine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.161", "l": "\"dimethylglycine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50900", "l": "10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O = (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18154", "l": "2 GTP + H(+) => diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044596", "l": "3-demethylubiquinol-10 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-10 = S-adenosyl-L-homocysteine + ubiquinol-10."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804193", "l": "TP53 stimulates PRDM1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928627", "l": "EPHB phosphorylates TIAM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218824", "l": "p-6Y-VEGFR2 binds FYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14269", "l": "2 a quinone + H(+) + NADPH = 2 a 1,4-benzosemiquinone + NADP(+)", "d": []}, {"i": "EC:1.6.5.5", "l": "\"NADPH:quinone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53750", "l": "a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26378", "l": "GTP => cyclic pyranopterin phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23279", "l": "2-dehydropantoate <=> 3-methyl-2-oxobutanoate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29130", "l": "a menaquinol + nitrate <=> a menaquinone + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68820", "l": "(2Z,6E)-farnesyl diphosphate + H2O = (6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46416", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.26", "l": "\"acyl-[acyl-carrier-protein] 6-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015577", "l": "galactitol transmembrane transporter activity", "d": ["Enables the transfer of a galactitol from one side of a membrane to the other. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose."]}, {"i": "RHEA:33143", "l": "galactitol(in) = galactitol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636461", "l": "PtpA binds Ubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36895", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50203", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64249", "l": "decanoyl-CoA + glycine => CoA + H(+) + N-decanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446364", "l": "Migfilin interacts with VASP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50619", "l": "NADP(+) + nonan-2-one <=> (3E)-nonen-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69611", "l": "H2O + kojibiose = beta-D-glucose + D-glucose", "d": []}, {"i": "EC:3.2.1.216", "l": "\"kojibiose hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68276", "l": "butanoyl-CoA + L-seryl-[protein] = CoA + O-butanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40097", "l": "2 H(+) + hexacosanedioate + NADH => 26-oxohexacosanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47750", "l": "a ubiquinol + n Na(+)(out) + NAD(+) => a ubiquinone + H(+) + n Na(+)(in) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769307", "l": "NPAS4 represses INS gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61294", "l": "2-dehydropantoate + H(+) + NADH => (R)-pantoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015494", "l": "aromatic amino acid:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: aromatic amino acid(out) + H+(out) = aromatic amino acid(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44879", "l": "a 1,3-diacylglycerol + H2O <=> 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824472", "l": "TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174235", "l": "Association of Emi1 with Cdc20 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25994", "l": "(+)-epi-isozizaene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71546", "l": "5-hydroxymethyl-dUMP in DNA + ATP <=> 5-phosphomethyl-dUMP in DNA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694527", "l": "Loss of SAR1B GTPase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57450", "l": "AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+) => ATP + D-tyrosine + tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66958", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9006873", "l": "IL21 receptor STAT binding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23664", "l": "A + a (2R)-2-hydroxycarboxylate = a 2-oxocarboxylate + AH2", "d": []}, {"i": "EC:1.1.99.30", "l": "\"2-oxo-acid reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40537", "l": "2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44236", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.16", "l": "\"3-carboxyethylcatechol 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9732729", "l": "Activated JAK1 binds RAF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050060", "l": "long-chain-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9007882", "l": "IL1F10 is cleaved (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48194", "l": "(2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33325", "l": "a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28280", "l": "H(+) + L-alanine + sulfite => 3-sulfino-L-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213207", "l": "Formation of collagen networks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9716913", "l": "ESR1 binds ESR1 antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68438", "l": "(3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial => (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13832", "l": "GDP-alpha-D-rhamnose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2317332", "l": "PIP3 recruits AKT to the membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21607", "l": "styrene oxide <=> 2-phenylacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64682", "l": "CoA + ethyl benzoate => benzoyl-CoA + ethanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29927", "l": "(R)-pantothenate(in) + Na(+)(in) = (R)-pantothenate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55335", "l": "a 3'-hydroxyflavone + S-adenosyl-L-methionine <=> a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389348", "l": "Activation of Rac1 by pVav1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63014", "l": "diphosphate + ilicicolinate B => (2E,6E)-farnesyl diphosphate + orsellinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75560", "l": "erinacol + O2 + reduced [NADPH--hemoprotein reductase] => cyathadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070463", "l": "tubulin-dependent ATPase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10980", "l": "L-serine = D-serine", "d": []}, {"i": "EC:5.1.1.18", "l": "\"serine racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11212", "l": "indole + O2 = 2-formamidobenzaldehyde", "d": []}, {"i": "EC:1.13.11.17", "l": "\"indole 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37196", "l": "octadecanoyl-CoA + sn-glycerol 3-phosphate => 1-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63356", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2 = (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14353", "l": "3-dehydro-L-gulonate 6-phosphate + H(+) = CO2 + L-xylulose 5-phosphate", "d": []}, {"i": "EC:4.1.1.85", "l": "\"3-dehydro-L-gulonate-6-phosphate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30984", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] => beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2250301", "l": "Formation of lysyl-pyrrole cross-links (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202722", "l": "CD48 binds CD244 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64688", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39623", "l": "3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36200", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983194", "l": "Kinesin-1 is a heterotetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45032", "l": "4 Fe(III)-[cytochrome c] + H2O + hydroxylamine = 4 Fe(II)-[cytochrome c] + 5 H(+) + nitrite", "d": []}, {"i": "EC:1.7.2.6", "l": "\"hydroxylamine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74723", "l": "Endosome acidification (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034935", "l": "tetrachlorobenzene dioxygenase activity", "d": ["Catalysis of the reaction: 2,4-dichlorotoluene + NADH + H+ + O2 = 4,6-dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629679", "l": "PDE3A inhibitors bind PDE3A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66984", "l": "3-methylbutanoyl-CoA + H2O = CoA + H(+) + isovalerate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10674", "l": "a thymidine dimer in DNA => cyclobutadithymidine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42916", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41539", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine <=> 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38907", "l": "(R)-reticuline + S-adenosyl-L-methionine = (R)-laudanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607751", "l": "TRAF6 oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9670014", "l": "Factor VIIIa dissociates  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22916", "l": "4'-hydroxyacetophenone + H(+) + NADPH + O2 = 4-acetoxyphenol + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.84", "l": "\"4-hydroxyacetophenone monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21489", "l": "dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O => beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25234", "l": "N-acetyl-alpha-neuraminate => N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67478", "l": "diphosphate + prekainate => dimethylallyl diphosphate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031855", "l": "oxytocin receptor binding", "d": ["Binding to an oxytocin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050468", "l": "reticuline oxidase activity", "d": ["Catalysis of the reaction: (S)-reticuline + O2 = (S)-scoulerine + H2O2 + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71164", "l": "homogentisate + O2 => maleylacetoacetate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69295", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate <=> goitrin + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450348", "l": "Activated human JNKs migrate to nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42198", "l": "(9Z,12Z)-heptadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-heptadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45118", "l": "H(+) + ipsdienone + NADPH => (4R)-ipsdienol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59336", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene + A = AH2 + demethylspheroidene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045330", "l": "aspartyl esterase activity", "d": ["Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0061665", "l": "SUMO ligase activity", "d": ["Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S = X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756439", "l": "Expression of SNAI1 during gastrulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.664775500092716", "identifiers": [{"i": "GO:0016799", "l": "hydrolase activity, hydrolyzing N-glycosyl compounds", "d": ["Catalysis of the hydrolysis of any N-glycosyl bond."]}, {"i": "EC:3.2.2.-", "l": "\"Hydrolyzing N-glycosyl compounds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944230", "l": "Association of procollagen type XVIII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395768", "l": "LPL hydrolyses TGs from mature CMs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75357", "l": "3-hydroxy-4H-pyrid-4-one + NH4(+) + pyruvate => H2O + L-mimosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134800", "l": "STING dimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56390", "l": "(4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69221", "l": "a (Z)-glucosinolate + H2O => a (Z)-N-(sulfonatooxy)alkanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570528", "l": "SUMOylation of XPC with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928576", "l": "RHOA:GTP binds ROCK, activating it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13379", "l": "ADP + alpha-D-glucose 1,6-bisphosphate + H(+) => alpha-D-glucose 1-phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54154", "l": "a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624125", "l": "Formation of the BBSome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033763", "l": "proline 3-hydroxylase activity", "d": ["Catalysis of the reaction: L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451347", "l": "Activation of JNK by DSCAM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186780", "l": "PI3-kinase binds to the active receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0070063", "l": "RNA polymerase binding", "d": ["Binding to an RNA polymerase molecule or complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17092", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate <=> D-glyceraldehyde 3-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70834", "l": "L-arginine(in) + L-leucine(out) + Na(+)(out) <=> L-arginine(out) + L-leucine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29055", "l": "a ubiquinone + 2 H(+)(in) + H2 = a ubiquinol + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29705", "l": "L-valine(out) => L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015086", "l": "cadmium ion transmembrane transporter activity", "d": ["Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604763", "l": "Autocatalytic activation of MMP7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182990", "l": "Sprouty sequesters CBL away from active EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60345", "l": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63105", "l": "H(+) + ilicicolin A epoxide + NADPH + O2 => 16-hydroxy-ilicicolin A epoxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23859", "l": "H(+) + Hg + NADP(+) <=> Hg(2+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044606", "l": "phosphocholine hydrolase activity", "d": ["Catalysis of the reaction: protein-serine-choline phosphate + H2O = protein-serine + choline phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53487", "l": "androst-4-ene-3,11,17-trione + H(+) + NADPH <=> 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32424", "l": "(1R,4R)-dihydrocarvone + A => (R)-carvone + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.225", "l": "\"F-actin monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-984606", "l": "Kinesin-5 is a homotetramer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072552", "l": "monoferuloyl di-(hydroxyferuloyl) spermidine meta-hydroxylase activity", "d": ["Catalysis of the reaction: monoferuloyl di-(hydroxyferuloyl) spermidine + NADPH + O2 = tri-(hydroxyferuloyl) spermidine + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798257", "l": "PTPRS binds NTRK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22242", "l": "N-(carboxyaminomethyl)urea + NH4(+) => H2O + methylenediurea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605768", "l": "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59397", "l": "L-leucine => D-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112392", "l": "Resumption of elongation after recovery from pausing (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14386", "l": "a dolichyl diphosphate + H2O => a dolichyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047621", "l": "acylpyruvate hydrolase activity", "d": ["Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203070", "l": "Association of profilin with monomeric actin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682983", "l": "ATM phosphorylates WHSC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209828", "l": "Tryptophan is hydroxylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17991", "l": "ADP + H(+) + O-phospho-L-seryl-[protein] => ATP + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0015216", "l": "purine nucleotide transmembrane transporter activity", "d": ["Enables the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41637", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O => 1-O-(1Z-alkenyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50472", "l": "anthraniloyl-CoA + H(+) + malonyl-CoA = (2-aminobenzoyl)acetyl-CoA + CO2 + CoA", "d": []}, {"i": "EC:2.3.1.262", "l": "\"anthraniloyl-CoA anthraniloyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36028", "l": "CoA + NAD(+) + propanal => H(+) + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427570", "l": "Group 3 - Selective Cl- transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655241", "l": "Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33147", "l": "ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate", "d": []}, {"i": "EC:7.6.2.2", "l": "\"ABC-type xenobiotic transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61411", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysine <=> ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72729", "l": "UDP-alpha-D-glucuronate(out) + UMP(in) => UDP-alpha-D-glucuronate(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73108", "l": "acacetin + S-adenosyl-L-methionine => apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163090", "l": "Elongation Of The Telomeric Chromosome End (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23448", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate", "d": []}, {"i": "EC:2.7.7.38", "l": "\"3-deoxy-manno-octulosonate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201622", "l": "Caspase-mediated cleavage of gelsolin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71189", "l": "AFMID hydrolyses NFK to L-KYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11552", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + H2O = 1-O-alkyl-sn-glycerol + acetate + H(+)", "d": []}, {"i": "EC:3.1.1.71", "l": "\"acetylalkylglycerol acetylhydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32040", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => AMP + ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047446", "l": "(1-hydroxycyclohexan-1-yl)acetyl-CoA lyase activity", "d": ["Catalysis of the reaction: (1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44987", "l": "(R)-carnitine + 3-methylbutanoyl-CoA <=> CoA + O-3-methylbutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682769", "l": "LGI2 binds ADAM22,23 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31384", "l": "(S)-2,3-epoxysqualene => lupeol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694421", "l": "PP6 dephosphorylates SEC24 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45597", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428752", "l": "Dissociation of the TP:Gq complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18438", "l": "4-CDP-2-C-methyl-D-erythritol + ATP => 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41585", "l": "dimethylallyl diphosphate + L-tyrosine => 4-O-dimethylallyl-L-tyrosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689544", "l": "UCHL5 binds INO80 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40447", "l": "(2R)-pristanoyl-CoA = (2S)-pristanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33085", "l": "5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine => dehypoxanthine futalosine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36606", "l": "2-oxoglutarate + L-enduracididine + O2 <=> (3S)-3-hydroxy-L-enduracididine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60655", "l": "an N-(acyl)-sphingosylphosphocholine <=> an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20014", "l": "carbamoyl phosphate + L-aspartate => H(+) + N-carbamoyl-L-aspartate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794338", "l": "GKAPs bind PSD-95 members (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33346", "l": "glycine + O2 <=> 2-iminoacetate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264865", "l": "Caspase-mediated cleavage of Lamin A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30768", "l": "D-glucurono-3,6-lactone + H2O => D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56228", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68021", "l": "(2E)-geranyl phosphate + H2O => (2E)-geraniol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015190", "l": "L-leucine transmembrane transporter activity", "d": ["Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167419", "l": "The receptor:G-protein complex releases GDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876472", "l": "NPC2 binds CHOL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26332", "l": "(8S)-8-amino-7-oxononanoate + L-lysine <=> (7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26523", "l": "(2S,3S)-2-methylcitrate => 2-methyl-trans-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59308", "l": "D-galactono-1,5-lactone + H2O = D-galactonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296043", "l": "Activation of HCN channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098973", "l": "structural constituent of postsynaptic actin cytoskeleton", "d": ["The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638006", "l": "ARL3 hydrolyzes GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008073", "l": "ornithine decarboxylase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of ornithine decarboxylase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75925", "l": "4-oxopentanoate + H(+) + NADH + NH4(+) => (S)-4-aminopentanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71055", "l": "L-cysteine(out) + L-methionine(in) = L-cysteine(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730488", "l": "SARS-CoV-2 nsp16 binds to U2 snRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701569", "l": "ALK- and STAT3-dependent HIF1A gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40514", "l": "(2S)-3-sulfopropanediol + NAD(+) <=> (2S)-3-sulfolactaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47386", "l": "acetate + H(+) + hydroquinone => 4-acetoxyphenol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63892", "l": "ATP + H2O + L-tryptophan = AMP + D-tryptophan + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669024", "l": "CD70 binds CD27 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140935", "l": "histone H2B conserved C-terminal lysine deubiquitinase activity", "d": ["A histone deubiquitinase that cleaves ubiquitin from the conserved C-terminal lysine residue of a histone H2B protein to which it is conjugated. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, and K120 in mammals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964280", "l": "Active Gq binds BTK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15853", "l": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22407", "l": "beta-D-galacturonate + NAD(+) <=> D-galactaro-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36538", "l": "docosanoyl-CoA + sphinganine <=> CoA + H(+) + N-docosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32921", "l": "(indol-3-yl)acetate + H(+) + methanol => H2O + methyl (indol-3-yl)acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25291", "l": "ethanol + NAD(+) => acetaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41097", "l": "H(+) + phosphocholine + sphing-4-enine => H2O + sphing-4-enine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734730", "l": "ORC1 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0048407", "l": "platelet-derived growth factor binding", "d": ["Binding to platelet-derived growth factor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045431", "l": "flavonol synthase activity", "d": ["Catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864569", "l": "WWOX binds TFAP2C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22342", "l": "3-hydroxybenzaldehyde + H(+) + NADPH => 3-hydroxybenzyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15112", "l": "2-dehydro-3-deoxy-D-gluconate + NADP(+) <=> (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22646", "l": "6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + protopine + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61082", "l": "(+)-echitovenine + CoA => (+)-minovincinine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65747", "l": "2-oxoglutarate + decyl sulfate + O2 <=> CO2 + decanal + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56632", "l": "H2O + neryl diphosphate = 1,8-cineole + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24165", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] => [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46667", "l": "corticosterone + H(+) + NADPH <=> 5beta-dihydrocorticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14586", "l": "gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008863", "l": "formate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: formate + NAD+ = CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54998", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61687", "l": "glycero-2-phosphocholine + H2O <=> glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54558", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate => a 5'-end ribonucleotide-tRNA(His) + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9633005", "l": "EIF2AK4 (GCN2) binds tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199093", "l": "CXADR binds to AMICA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46480", "l": "4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73628", "l": "CTP(out) + GMP(in) => CTP(in) + GMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102657", "l": "1-18:1-2-16:0-monogalactosyldiacylglycerol palmitoyl-lipid 7-desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050264", "l": "rifamycin-B oxidase activity", "d": ["Catalysis of the reaction: 2 H+ + O2 + rifamycin B = H2O2 + rifamycin O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46193", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24122", "l": "20-hydroxy-leukotriene E4 + H2O + NADP(+) => H(+) + leukotriene E4 + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59484", "l": "arsenite + 2 Fe(III)-[cytochrome c] + H2O = arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": []}, {"i": "EC:1.20.2.1", "l": "\"arsenate reductase (cytochrome c)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77589", "l": "Recognition of AAUAAA sequence by CPSF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68662", "l": "17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) 17-sulfate + adenosine 3',5'-bisphosphate + H(+) => 17beta-estradiol 3-O-(beta-D-glucuronate) 17-sulfate + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2464803", "l": "RDH8 reduces atRAL to atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350598", "l": "Arginine<=>Agmatine+CO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27294", "l": "D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.1.98.2", "l": "\"glucose-6-phosphate dehydrogenase (coenzyme-F420)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47433", "l": "(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695838", "l": "Ligand-independent dimerization of FLT3 mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432121", "l": "LDL binds to LRP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810843", "l": "Envoplakin binds periplakin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63345", "l": "ATP + L-amino acyl-L-threonyl-[protein] => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9689680", "l": "IFNG dimer binds IFNG inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53992", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174058", "l": "Degradation of multiubiquitinated Cdh1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61388", "l": "ATP + biotin(in) + H2O = ADP + biotin(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56387", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 <=> (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2172678", "l": "PHF8 demethylates histone H4K20me1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22992", "l": "3-oxopropanoate + CoA + NAD(+) = acetyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140984", "l": "histone H4K12 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 12) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 12). This reaction is the addition of a methyl group to the lysine residue at position 12 of the histone H4 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47431", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) <=> 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.64", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46795", "l": "an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72303", "l": "L-glutamate(in) + L-thyroxine(out) = L-glutamate(out) + L-thyroxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44522", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75654", "l": "(10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate <=> 12,13-epoxy-(10R)-hydroxy-(8E,15Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043777", "l": "cobalt-precorrin-7 C15-methyltransferase activity", "d": ["Catalysis of the reaction: cobalt-precorrin 7 + S-adenosyl-L-methionine = cobalt-precorrin 8 + S-adenosyl-L-homocysteine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50945", "l": "3-phenylpropanoate + NAD(+) => (E)-cinnamate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62555", "l": "beta-D-glucosylceramide + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75021", "l": "9-(10Z-heptadecenoyloxy)-octadecanoate + di-(10Z)-heptadecenoylglycerol => 1,2,3-tri-(10Z)-heptadecenoylglycerol + 9-hydroxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44264", "l": "eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57994", "l": "(20S)-ginsenoside F2 + H(+) + UDP => (20S)-ginsenoside C-K + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54830", "l": "formaldehyde + H2O + methylamine + NADP(+) => dimethylamine + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5220959", "l": "TDG excises 5-formylcytosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141367", "l": "Myristoylation of tBID by NMT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31150", "l": "3,4-dihydroxyphenylethyleneglycol + NAD(+) <=> 3,4-dihydroxymandelaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44729", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10856", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose = a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36957", "l": "(9Z)-pentadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2399913", "l": "atRAL binds to RBP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64928", "l": "dADP + H2O = dAMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909724", "l": "Recruitment of IFNAR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31219", "l": "5-hydroxykynurenamine + CO2 = 5-hydroxy-L-kynurenine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43784", "l": "adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.286", "l": "\"25S rRNA (adenine(2142)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5607746", "l": "PKC-delta is activated (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38609", "l": "nicotinate-adenine dinucleotide phosphate => 2'-phospho-cyclic ADP-ribose + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33161", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163539", "l": "perilipin:CGI-58 complex -> perilipin + CGI-58 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35868", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53962", "l": "4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O => 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062240", "l": "euchromatin-nuclear membrane anchor activity", "d": ["Binding to euchromatin and the nuclear inner membrane, in order to establish and maintain the euchromatin location and organization."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41152", "l": "1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905334", "l": "Swi5-Sfr1 complex binding", "d": ["Binding to a Swi5-Sfr1 complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015539", "l": "hexuronate:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexuronate(out) + cation(out) = hexuronate(in) + cation(in). The hexuronate may be glucuronate or galacturonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333678", "l": "CPNEs bind PL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-555065", "l": "Formation of clathrin coated vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72561", "l": "estrone 3-sulfate(in) + pentanoate(out) => estrone 3-sulfate(out) + pentanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010013", "l": "N-1-naphthylphthalamic acid binding", "d": ["Binding to N-1-naphthylphthalamic acid, an auxin transport inhibitor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186780", "l": "PI3-kinase binds to the active receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69188", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate = ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24296", "l": "(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate", "d": []}, {"i": "EC:3.5.2.3", "l": "\"dihydroorotase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75801", "l": "Na(+)(in) + pyruvate(in) => Na(+)(out) + pyruvate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28857", "l": "H(+)(out) + melibiose(out) => H(+)(in) + melibiose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873917", "l": "Translocation of STAT1 dimer to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451033", "l": "(S)-Malate <=> Fumarate + H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "64.987832356016085", "identifiers": [{"i": "GO:0004674", "l": "protein serine/threonine kinase activity", "d": ["Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57337", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose => 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30952", "l": "(2E,6E)-farnesyl diphosphate + H2O => alpha-eudesmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68468", "l": "(2Z,6Z)-farnesyl diphosphate = (E)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23304", "l": "atropine + H2O = H(+) + tropate + tropine", "d": []}, {"i": "EC:3.1.1.10", "l": "\"tropinesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052749", "l": "glucose-6-phosphate dehydrogenase (coenzyme F420) activity", "d": ["Catalysis of the reaction: beta-D-glucose 6-phosphate + coenzyme F420 + H+ = 6-O-phosphono-D-glucono-1,5-lactone + reduced coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169402", "l": "ISGylation of E2 conjugating enzymes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204798", "l": "Interaction of Tie2 and p85 of PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77589", "l": "Recognition of AAUAAA sequence by CPSF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37600", "l": "(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 => (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72968", "l": "4-methyl-2-oxopentanoate(out) + 2 Na(+)(out) => 4-methyl-2-oxopentanoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51646", "l": "7-dehydrocholesterol + 2 H2O + NAD(+) => cholesterol + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31912", "l": "beta-D-fructose 1,6-bisphosphate + methylglyoxal => 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41376", "l": "1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69328", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate = 5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018814", "l": "RHOT1 hydrolyzes GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788622", "l": "p-Y-STATs dimerize (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17939", "l": "methylglyoxal + phosphate => dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.2", "l": "\"small monomeric GTPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14583", "l": "2 L-ascorbate + NAD(+) => H(+) + 2 monodehydro-L-ascorbate radical + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004324", "l": "ferredoxin-NADP+ reductase activity", "d": ["Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60980", "l": "12-hydroxydodecanoate + NAD(+) = 12-oxododecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19337", "l": "2 hydroxylamine + 2 NAD(+) = 2 H(+) + hyponitrous acid + 2 NADH", "d": []}, {"i": "EC:1.7.1.5", "l": "\"hyponitrite reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937807", "l": "SRC phosphorylates RUNX3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690449", "l": "S1PR1 bind S1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73146", "l": "CoA(out) + FAD(in) <=> CoA(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73337", "l": "AMP + beta-alanyl-tryptamine + diphosphate + H(+) => ATP + beta-alanine + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19076", "l": "ATP + L-seryl-[I-kappa-B protein] <=> ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404193", "l": "IGF1R phosphorylates SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37152", "l": "(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate => 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35921", "l": "H(+) + kanamycin D + UDP => 2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390425", "l": "FAR1 reduces PalmCoA to HXOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47135", "l": "11-cis-retinal + H2O + NAD(+) <=> 11-cis-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62173", "l": "an N-acylethanolamine phosphate + H2O => an N-acylethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44983", "l": "(R)-carnitine + butanoyl-CoA <=> CoA + O-butanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18181", "l": "acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.9", "l": "\"malate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18567", "l": "9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine => 19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382061", "l": "Extracellular processing of novel PDGFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655849", "l": "Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044589", "l": "pectin binding", "d": ["Binding to pectin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901097", "l": "kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51989", "l": "(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => 18S-resolvin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29412", "l": "glycolate(in) + H(+)(in) => glycolate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005561", "l": "Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50019", "l": "H2O + octanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050070", "l": "lysolecithin acylmutase activity", "d": ["Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine = 2-acyl-sn-glycero-3-phosphocholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160931", "l": "Disassembly of tight junctions (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193997", "l": "CYP11B1 oxidises 11DCORT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63197", "l": "(10bR,4aS)-noroxomaritidine + H(+) + NADPH => (10bR,4aS)-oxomaritidine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097256", "l": "phenyllactate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-3-phenyllactate + NAD+ = 3-phenylpyruvate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65340", "l": "acetyl-CoA + L-threonyl-[protein] = CoA + O-acetyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28138", "l": "H2O + streptothricin F = streptothricin F acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426223", "l": "Cation influx mediated by TRPC3/6/7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25225", "l": "L-arabinitol + NAD(+) = H(+) + L-arabinose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53995", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37426", "l": "aclacinomycin N + O2 <=> aclacinomycin A + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140954", "l": "histone H3K36 dimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl36-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl36-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48545", "l": "[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine => [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110459", "l": "PIP3 dephosphorylated to PIP2 by DPTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65704", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-3,6-dideoxy-alpha-D-mannose = alpha-D-Tyv-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56785", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O => (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605723", "l": "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0001025", "l": "RNA polymerase III general transcription initiation factor binding", "d": ["Binding to an RNA polymerase III transcription factor, a protein required to initiate or regulate transcription by RNA polymerase III."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218642", "l": "PTK2 autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56808", "l": "ATP + cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] = adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39533", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31643", "l": "mycinamicin VI + S-adenosyl-L-methionine = H(+) + mycinamicin III + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.238", "l": "\"mycinamicin VI 2''-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50937", "l": "(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate => acetoacetyl-CoA + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787820", "l": "IL34 dimer binds CSF1R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72861", "l": "A[3'-5']pA[3'-5']pAp[3'] + H(+) => 3',3',3'-c-tri-AMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034779", "l": "4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + H2O = 3-isopropenylpimelyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26544", "l": "(R)-piperazine-2-carboxylate + NH4(+) => (R)-piperazine-2-carboxamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48631", "l": "a ribonucleotide in rRNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52616", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP = 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031859", "l": "platelet activating factor receptor binding", "d": ["Binding to a platelet activating factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39004", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O => a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442387", "l": "ZIP8 mediates zinc influx into cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30524", "l": "GTP + L-glutamate + oxidized coenzyme F420-1 => GDP + H(+) + oxidized coenzyme F420-2 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2250301", "l": "Formation of lysyl-pyrrole cross-links (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72891", "l": "acetylcholine(out) + 2 H(+)(in) = acetylcholine(in) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73483", "l": "D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.50", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191303", "l": "FDPS dimer transfers IPPP to GPP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0019196", "l": "galactosamine transmembrane transporter activity", "d": ["Enables the transfer of galactosamine from one side of a membrane to the other. Galactosamine is an aminodeoxysugar; D-galactosamine is a constituent of some glycolipids and glycosaminoglycans, commonly as its N-acetyl derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109701", "l": "PDPK1 binds PIP3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24402", "l": "ADP + UDP => ATP + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607747", "l": "TRAF6 binds MALT1 oligomers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51152", "l": "2 a thiol + L-cysteinyl-[sulfatase] + O2 = 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide", "d": []}, {"i": "EC:1.8.3.7", "l": "\"formylglycine-generating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30883", "l": "D-glucurono-3,6-lactone + 2 H2O + NAD(+) = D-glucarate + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018689", "l": "naphthalene disulfonate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098919", "l": "structural constituent of postsynaptic density", "d": ["The action of a molecule that contributes to the structural integrity of a postsynaptic density."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24357", "l": "a 1-acyl-sn-glycero-3-phosphocholine => a 2-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693111", "l": "RHOF auto-activates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40708", "l": "(9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate => 1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16350", "l": "AH2 + chlorate => A + chlorite + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74347", "l": "O-acyl-(R)-carnitine(in) = O-acyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13912", "l": "phosphate + urate D-ribonucleoside <=> alpha-D-ribose 1-phosphate + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14796", "l": "2-hydroxyadipate + NAD(+) <=> 2-oxoadipate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64658", "l": "(E)-sinapoyl-CoA + H(+) + NADPH => (E)-sinapaldehyde + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61619", "l": "H(+) + L-proline betaine + NADH + O2 <=> formaldehyde + H2O + N-methyl-L-proline + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10682", "l": "D-proline => L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627056", "l": "Procaspase 9 forms dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39869", "l": "3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+) => 3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60807", "l": "2-oxoglutarate + gibberellin A19 + O2 <=> CO2 + gibberellin A17 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371422", "l": "ATP hydrolysis by HSP70 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75159", "l": "NAD(+) + TTP = H(+) + NADP(+) + TDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0051920", "l": "peroxiredoxin activity", "d": ["Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71266", "l": "chloride(out) + L-proline(out) + 2 Na(+)(out) <=> chloride(in) + L-proline(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015499", "l": "formate transmembrane transporter activity", "d": ["Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid."]}, {"i": "RHEA:29679", "l": "formate(in) = formate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849906", "l": "SALM1 binds NMDA receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098604", "l": "adenosylselenohomocysteinase activity", "d": ["Catalysis of the reaction: Se-Adenosyl-L-selenohomocysteine + H2O => Adenosine + Selenohomocysteine."]}, {"i": "REACT:R-HSA-2408532", "l": "AdeSeHCys is hydrolysed to SeHCys by AHCY (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9796368", "l": "RIPK1 binds STUB1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032035", "l": "myosin II tail binding", "d": ["Binding to the tail region of a myosin II heavy chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17545", "l": "[protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] = [protein]-disulfide + ADP + phosphate + S-hydroxy-L-cysteinyl-[peroxiredoxin]", "d": []}, {"i": "EC:1.8.98.2", "l": "\"sulfiredoxin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940561", "l": "MMP7 cleaves OPTC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665748", "l": "FMNL2 binds RHOC:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32584", "l": "dihydrocarvone + H(+) + NADPH + O2 => 6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47569", "l": "ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GD1b (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57546", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1 => (S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31388", "l": "(S)-2,3-epoxysqualene => alpha-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20351", "l": "2-hydroxytoluene + H2O + NAD(+) => H(+) + NADH + O2 + toluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69848", "l": "a 5,6-dihydrouridine in RNA + NADP(+) => a uridine in RNA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74825", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA => 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130194", "l": "ABL phosphorylates WAVEs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693243", "l": "RHOD translocates to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42812", "l": "cholesterol + octadecanoyl-CoA = cholesteryl octadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797100", "l": "CCNK binds CDK13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730858", "l": "Autophosphorylation of BTK/ITK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0004738", "l": "pyruvate dehydrogenase activity", "d": ["Catalysis of the oxidative decarboxylation of pyruvate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080107", "l": "8-methylthiopropyl glucosinolate S-oxygenase activity", "d": ["Catalysis of the reaction: 8-methylthiopropyl-glucosinolate = 8-methylsulfinylpropyl-glucosinolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32560", "l": "(2E)-geranyl diphosphate => diphosphate + gamma-terpinene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41053", "l": "1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68296", "l": "dodecanoyl-CoA + L-seryl-[protein] = CoA + O-dodecanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683735", "l": "mRNA9 is translated to Nucleoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3858475", "l": "ppDVL recruits RAC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395784", "l": "Nascent CMs transform into mature CMs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29192", "l": "L-aspartate + menaquinone-8 => iminosuccinate + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698962", "l": "Binding of pPR-AP to pAP to form the pPR-AP:pAP Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76115", "l": "2-oxoglutarate + O2 + thebaine = 6-O-demethylthebaine + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31625", "l": "H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine => L-olivosyl-oleandolide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66561", "l": "(R)-noradrenaline + L-glutaminyl-[protein] => 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14236", "l": "a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.94", "l": "\"glucan 1,6-alpha-isomaltosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51758", "l": "a 2-acyl-4,6-diprenylphloroglucinol + diphosphate => a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11288", "l": "dihydromacarpine + H(+) + O2 = H2O2 + macarpine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11499", "l": "O-acetyl-L-serine + uracil <=> 3-(uracil-1-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928620", "l": "PAK1 autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52666", "l": "a short-chain (2E)-enoyl-CoA + H2O => a short-chain (3S)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264865", "l": "Caspase-mediated cleavage of Lamin A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50980", "l": "prostaglandin E1(out) = prostaglandin E1(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668904", "l": "Formation of the CTF18 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004992", "l": "platelet activating factor receptor activity", "d": ["Combining with platelet activating factor to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16695", "l": "(Z)-2-methyl-5-isopropylhexa-2,5-dienal => alpha-pinene oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.535054500181104", "identifiers": [{"i": "GO:0070567", "l": "cytidylyltransferase activity", "d": ["Catalysis of the transfer of a cytidylyl group to an acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9725206", "l": "IgE binds FCERI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55291", "l": "tetradecan-1-ol + tetradecanoyl-CoA <=> CoA + tetradecanyl tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37511", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619214", "l": "CaMKK binds activated calmodulin in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444647", "l": "C3a receptor binds anaphylatoxin C3a (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37083", "l": "[sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine = [sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.819490397197882", "identifiers": [{"i": "GO:0061659", "l": "ubiquitin-like protein ligase activity", "d": ["Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683735", "l": "CHEK2 is recruited to DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70402", "l": "3-oxosphinganine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45327", "l": "H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66011", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen] <=> [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196964", "l": "RFK:Mg2+ phosphorylates RIB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24704", "l": "CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose => NAD(+) + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56383", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 <=> (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44671", "l": "4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol <=> 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050361", "l": "tryptophan 2-monooxygenase activity", "d": ["Catalysis of the reaction: L-tryptophan + O2 = CO2 + H2O + indole-3-acetamide."]}]}
{"type": "biolink:MolecularActivity", "ic": "72.161881760686384", "identifiers": [{"i": "GO:0046872", "l": "metal ion binding", "d": ["Binding to a metal ion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28844", "l": "choline(in) + H(+)(in) => choline(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55493", "l": "ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29842", "l": "L-idonate + NADP(+) <=> 2-dehydro-L-idonate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.293", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55859", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18372", "l": "O2 + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53288", "l": "3-dehydro-scyllo-inosose + H2O = 5-dehydro-L-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442592", "l": "WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67693", "l": "ATP + H2O + hexadecanedioate(in) => ADP + H(+) + hexadecanedioate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.2.-", "l": "\"In cyclic amides\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61597", "l": "[DsbD protein]-dithiol + [thioredoxin]-disulfide => [DsbD protein]-disulfide + [thioredoxin]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37663", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.312", "l": "\"protein O-mannose beta-1,4-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483186", "l": "PC is converted to PS by PTDSS1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606807", "l": "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57862", "l": "CoA + scopoletin => (E)-6-hydroxyferuloyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59715", "l": "D-maltotetraono-1,5-lactone + H2O <=> D-maltotetraonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0005277", "l": "acetylcholine transmembrane transporter activity", "d": ["Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions."]}, {"i": "REACT:R-HSA-264615", "l": "Loading of acetylcholine in synaptic vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73145", "l": "CoA(in) + FAD(out) => CoA(out) + FAD(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51415", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> (8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57289", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O => a guanosine in RNA + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848713", "l": "PTK6 binds BCAR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53742", "l": "[Rab1 protein]-L-tyrosine + AMP + H(+) => [Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53657", "l": "(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 => (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70424", "l": "an acyl-CoA + H2O => a carboxylate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40576", "l": "glutaryl-CoA + H2O => CoA + glutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74163", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693347", "l": "CRYM reduces P2C to PPCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63531", "l": "[thioredoxin]-dithiol + H2O2 <=> [thioredoxin]-disulfide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65181", "l": "AH2 + O2 + protoaustinoid B => A + H2O + preaustinoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.9", "l": "\"tripeptidyl-peptidase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31607", "l": "rhodopin = all-trans-lycopene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1169192", "l": "PTP1B dephosphorylates GHR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800380", "l": "PTPRD binds IL1RAP-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201691", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229283", "l": "LCNs bind lipids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.863640214551324", "identifiers": [{"i": "GO:0004035", "l": "alkaline phosphatase activity", "d": ["Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9726875", "l": "HCNs:cAMP bind SNIs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0000992", "l": "RNA polymerase III cis-regulatory region sequence-specific DNA binding", "d": ["Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62915", "l": "H(+) + NADH + O2 + toralactone <=> 1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72443", "l": "(E)-feruloyl-AMP + CoA = (E)-feruloyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60002", "l": "formate + 2 H(+) + phosphate => hydroxymethylphosphonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848873", "l": "PTK6 phosphorylates ARAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374664", "l": "Phosphorylation and activation of Ezrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20209", "l": "ATP + xylitol = ADP + H(+) + xylitol 5-phosphate", "d": []}, {"i": "EC:2.7.1.122", "l": "\"xylitol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64877", "l": "H2O + UDP => H(+) + phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53634", "l": "(3S)-(+)-asterisca-2(9),6-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358790", "l": "RNF41 ubiquitinates ERBB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0160011", "l": "NAD-dependent protein decrotonylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:69332", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] + NAD(+) = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061809", "l": "NAD+ nucleotidase, cyclic ADP-ribose generating", "d": ["Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose that proceeds in a stepwise fashion by ADP-ribosyl cyclase activity followed by cyclic ADP-ribose hydrolase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373746", "l": "SEMA4D interacts with CD45 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804383", "l": "PRMT5 methylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102634", "l": "1,3,6,8-tetrahydroxynaphthalene monooxygenase (quinone-forming) activity", "d": ["Catalysis of the reaction: naphthalene-1,3,6,8-tetrol + O2 <=> flaviolin-2-olate + H2O + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74748", "l": "De-phosphorylation of p-Y427-SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57168", "l": "(R)-2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30501", "l": "(E)-2-methylpropanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-valine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46477", "l": "4alpha-hydroxymethylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formylzymosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080061", "l": "indole-3-acetonitrile nitrilase activity", "d": ["Catalysis of the reaction: indole-3-acetonitrile + 2 H2O = indole-3-acetic acid + NH3."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102148", "l": "N-acetyl-beta-D-galactosaminidase activity", "d": ["Catalysis of the reaction: H2O + an N-acetyl-beta-D-galactosalaminyl-[glycan] = N-acetyl-beta-D-galactosamine + a glycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52103", "l": "5-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171288", "l": "Cleavage of the viral Env gp160 precursor polyprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389352", "l": "Translocation of Vav1 to CD28 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68758", "l": "8 AMP + 8 diphosphate + 8 H(+) + PF1022B + 4 S-adenosyl-L-homocysteine => 4 (R)-3-phenyllactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30748", "l": "FAD + H(+) + hexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21632", "l": "2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O", "d": []}, {"i": "EC:1.10.3.1", "l": "\"catechol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10808", "l": "(S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)-epoxypropylphosphonate + 2 H2O", "d": []}, {"i": "EC:1.11.1.23", "l": "\"(S)-2-hydroxypropylphosphonic acid epoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57831", "l": "dIMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10776", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433374", "l": "Processing of SCF isoform 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390302", "l": "tetracosenoyl-CoA + 8 O2 + 8 H2O + 8 NAD+ + 8 CoASH => octanoyl-CoA + 8 H2O2 + 8 NADH + 8 H+ + 8 acetyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44780", "l": "2-demethylmenaquinol-9 + S-adenosyl-L-methionine = H(+) + menaquinol-9 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696358", "l": "TREM,CD300 binds lipids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43770", "l": "N(5)-alkyl-L-glutaminyl-[protein] + NH4(+) => an alkylamine + L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190265", "l": "FGFR4 binds to FGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29896", "l": "ATP + H2O + L-glutamine(out) => ADP + H(+) + L-glutamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022876", "l": "protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactosamine(out) = protein histidine + galactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33184", "l": "citrate(in) => citrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16887", "l": "bilirubin IXalpha + bilirubin-bisglucuronoside => 2 bilirubin-glucuronoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33083", "l": "dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine", "d": []}, {"i": "EC:1.21.98.1", "l": "\"cyclic dehypoxanthinyl futalosine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050218", "l": "propionate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14397", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) = (4Z)-2-oxohept-4-enedioate + CO2", "d": []}, {"i": "EC:4.1.1.68", "l": "\"5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74733", "l": "Insulin receptor de-phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18434", "l": "cyclohexylamine + H2O + O2 => cyclohexanone + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247847", "l": "WLS is endocytosed to the early endosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928625", "l": "PAKs autophosphorylate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75862", "l": "Fall Back to Closed Pre-initiation Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018766", "l": "RHOU binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40700", "l": "1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol => 1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56335", "l": "5'-triphosphoadenylyl-(2'->5')-adenosine + H2O <=> AMP + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11451", "l": "NAD(+) + pregnan-21-ol <=> H(+) + NADH + pregnan-21-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38483", "l": "a 2,3-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944215", "l": "Association of procollagen type XX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16734", "l": "H(+) + orsellinate => CO2 + orcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40218", "l": "FADH2 + O2 <=> FAD + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14016", "l": "3'-phosphoadenylyl sulfate + taurolithocholate <=> adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16237", "l": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)", "d": []}, {"i": "EC:5.2.1.8", "l": "\"peptidylprolyl isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698926", "l": "HCMV Genome Replication Completion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57406", "l": "H(+) + NADH + noscapine => NAD(+) + narcotine hemiacetal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18152", "l": "H2O + N-acetyl-D-galactosamine 6-phosphate <=> acetate + D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31451", "l": "2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2214324", "l": "Collagen type VII dimerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60359", "l": "H2O + N-octanoylanthranilate <=> anthranilate + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53488", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH = 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40476", "l": "1,2,3-tributanoylglycerol + H2O => butanoate + dibutanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75240", "l": "acetyl-CoA + N-terminal L-methionyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847534", "l": "RAB43 hydrolyses GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23179", "l": "acetate + ATP + CoA <=> acetyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44053", "l": "alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35994", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23451", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP <=> CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54571", "l": "a uridine in rRNA <=> a pseudouridine in rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980061", "l": "JAG2 binds NOTCH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013159", "l": "CDC42 GEFs activate CDC42 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50764", "l": "4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine = 4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51285", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849878", "l": "PSD-95 binds NMDA receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66653", "l": "(2E,6E)-farnesyl diphosphate => african-1-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53570", "l": "18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50094", "l": "an N-fatty acyl-taurine + CoA + H(+) => a fatty acyl-CoA + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047004", "l": "UDP-N-acetylglucosamine 6-dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + 2 NAD+ + UDP-N-acetyl-alpha-D-glucosamine = 3 H+ + 2 NADH + UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40989", "l": "ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O => EDTA + 2 FMNH2 + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44556", "l": "4-hydroxybenzoate + all-trans-hexaprenyl diphosphate = 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080089", "l": "sinapoyl spermidine:sinapoyl CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of a sinapoyl group to a nitrogen atom on a sinapoyl spermidine molecule resulting in the formation of a disinapoyl spermidine derivative."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106431", "l": "N6-methyl-(d)ATP hydrolase activity", "d": ["Catalysis of the reaction N6-methyl-(d)ATP + H2O = N6-methyl-(d)AMP + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28277", "l": "(S)-S-adenosyl-L-methionine <=> (R)-S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64364", "l": "prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44109", "l": "H2O + heptanal + NAD(+) => 2 H(+) + heptanoate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51762", "l": "a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate => a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42559", "l": "uridine(2819) in 21S rRNA <=> pseudouridine(2819) in 21S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0003880", "l": "protein C-terminal carboxyl O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050215", "l": "propanediol dehydratase activity", "d": ["Catalysis of the reaction: propane-1,2-diol = H2O + propanal."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047431", "l": "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity", "d": ["Catalysis of the reaction: 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H+ = 5-hydroxy-6-methylpyridine-3-carboxylate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62270", "l": "3-methyl-2-oxobutanoate + H(+) + NADPH => (R)-2-hydroxy-3-methylbutyrate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75332", "l": "chloride(out) + D-methionine(out) + 2 Na(+)(out) => chloride(in) + D-methionine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.79", "l": "\"hormone-sensitive lipase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655836", "l": "Expression of Diphosphomevalonate Decarboxylase (MVD) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70964", "l": "D-phenylalanine + H2O + O2 => 3-phenylpyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20109", "l": "alpha-D-ribose 1,5-bisphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP", "d": []}, {"i": "EC:2.7.4.23", "l": "\"ribose 1,5-bisphosphate phosphokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54130", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611852", "l": "ADRB3 bind ADR,NAd (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62090", "l": "2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH => D-glucosamine 6-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807872", "l": "Active ARF recruits coatomer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373734", "l": "Nephrin interacts with Podocin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51639", "l": "a quinone + H2O + selenite <=> a quinol + selenate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990310", "l": "type-III dockerin domain binding", "d": ["Binding to a type-III dockerin domain of a protein. Type-III dockerin domain is the binding partner of type-III cohesin domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77589", "l": "Recognition of AAUAAA sequence by CPSF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56282", "l": "AMP + L-prolyl-[peptidyl-carrier protein] => 3'-L-prolyl-AMP + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34612", "l": "N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose => H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22778", "l": "2 H2O + 2 Mn(3+) => 2 H(+) + H2O2 + 2 Mn(2+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442387", "l": "ZIP8 mediates zinc influx into cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692794", "l": "p-S215 FOXO1 positively regulates RAG gene expression  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53889", "l": "D-glucose 6-phosphate + TDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + H(+) + TDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28251", "l": "acetyl-CoA + H(+) + malonyl-CoA => acetoacetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73926", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + S-adenosyl-L-methionine <=> griseophenone D + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042658", "l": "MHC class II protein binding, via antigen binding groove", "d": ["Binding to the antigen binding groove of major histocompatibility complex class II molecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66349", "l": "3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A => (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40230", "l": "3'-phosphoadenylyl sulfate + desulfo-A47934 <=> A47934 + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714483", "l": "RAC2 translocates to the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49562", "l": "(R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate => D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682983", "l": "ATM phosphorylates WHSC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12035", "l": "a 3-(acyloxy)acyl derivative of bacterial toxin + H2O <=> 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6795473", "l": "PDPK1 phosphorylates SGK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944047", "l": "JUN binds the PTEN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34873", "l": "methanol(in) => methanol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026891", "l": "NTRK2 activates RAS signaling through SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0038085", "l": "vascular endothelial growth factor binding", "d": ["Binding to a vascular endothelial growth factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63838", "l": "(2R)-2-hydroperoxyhexadecanoate => hexadecanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19422", "l": "(R)-2-hydroxypropyl-coenzyme M => (R)-1,2-epoxypropane + coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014293", "l": "RAC2 GDIs block activation of RAC2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11550", "l": "5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+) => 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62869", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2 => H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653886", "l": "B4GALT1 binds LALBA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983144", "l": "Transport of Antigen peptide in to ER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25425", "l": "diphosphate + GMP => 5-phospho-alpha-D-ribose 1-diphosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34846", "l": "7,8-dihydromonapterin 3'-triphosphate + 3 H2O <=> 7,8-dihydromonapterin + 2 H(+) + 3 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693761", "l": "FA2H hydroxylates CERA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168280", "l": "Priming and Initiation of Transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13899", "l": "prephenate => chorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10710", "l": "diphosphate + GDP-D-glucose => alpha-D-glucose 1-phosphate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25552", "l": "9alpha-copalyl diphosphate = diphosphate + stemar-13-ene", "d": []}, {"i": "EC:4.2.3.33", "l": "\"stemar-13-ene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26412", "l": "(R)-lactate + N-acetyl-D-glucosamine 6-phosphate => H2O + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67670", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2201341", "l": "Endocytosis of TRAM (TICAM2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033569", "l": "lactoferrin transmembrane transporter activity", "d": ["Enables the transfer of lactoferrin from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46508", "l": "NADH + nitrobenzene + O2 = catechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16594", "l": "3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine => 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204871", "l": "Interaction of Tie2 and Grb2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31086", "l": "H2O + N-acetyl-D-muramoyl-L-alanine <=> L-alanine + N-acetyl-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50009", "l": "6-methylpretetramide + 2 H(+) + NADPH + O2 => 4-hydroxy-6-methylpretetramide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936356", "l": "GUCY2C trimer binds sta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374337", "l": "Apelin receptor binds to apelin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39128", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47867", "l": "1,2,3-trioctanoylglycerol + H2O <=> dioctanoylglycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102868", "l": "24-epi-campsterol desaturase activity", "d": ["Catalysis of the reaction: 24-epi-campesterol + NADPH + H+ + O2 <=> brassicasterol + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15131", "l": "(1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018566", "l": "1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxynaphthalene-6-sulfonate + O2 = H+ + (Z)-4-(2-hydroxy-5-sulfonatophenyl)-2-oxo-3-butenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357472", "l": "PAK1-3 autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37981", "l": "2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine => 2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110311", "l": "POLZ extends translesion synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11678", "l": "D-ribonate + 2 H(+) + NADPH => D-ribose + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0036455", "l": "iron-sulfur transferase activity", "d": ["Catalysis of the transfer of a iron-sulfur cluster from one compound (donor) to another (acceptor)."]}, {"i": "REACT:R-HSA-2564828", "l": "CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757434", "l": "Acetylsalicylic acid dissolves (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004459", "l": "L-lactate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69361", "l": "bromide + H(+) + H2O2 + L-tyrosyl-[protein] => 3-bromo-L-tyrosyl-[protein] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75412", "l": "demethyllactenocin + S-adenosyl-L-methionine => H(+) + lactenocin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59496", "l": "(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9761421", "l": "CDH11 associates with catenins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:1990107", "l": "thiazole synthase activity", "d": ["Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O."]}, {"i": "RHEA:26297", "l": "1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O", "d": []}, {"i": "EC:2.8.1.10", "l": "\"thiazole synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64833", "l": "3-hydroxybenzyl alcohol + benzoyl-CoA => 3-hydroxy-benzyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52815", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088134", "l": "PLK1 phosphorylates FOXM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32394", "l": "(1R,2R,4R)-dihydrocarveol + NAD(+) <=> (1R,4R)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.42903515889401", "identifiers": [{"i": "GO:0005543", "l": "phospholipid binding", "d": ["Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49819", "l": "3 Fe(III)-[cytochrome c] + H2O + hydrazine <=> 3 Fe(II)-[cytochrome c] + 2 H(+) + NH4(+) + nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229283", "l": "LCNs bind lipids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10771", "l": "(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 <=> (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9035484", "l": "CysS248-MPST:TXN2 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31580", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate => (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17445", "l": "H2 + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.12.7.2", "l": "\"ferredoxin hydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849435", "l": "PTPN1 dephosphorylates PTK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9793472", "l": "RIPK3 binds p-S9-PRKN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20098", "l": "D-mannonate => 2-dehydro-3-deoxy-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48756", "l": "erythritol + NAD(+) = D-erythrulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18225", "l": "[N-(6-aminohexanoyl)](n) + H2O = 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54802", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-histidyl-[protein] => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26444", "l": "a ubiquinol + acetaldehyde => a ubiquinone + ethanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41528", "l": "(2E)-octenoyl-[ACP] + H(+) + NADH = NAD(+) + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050614", "l": "delta24-sterol reductase activity", "d": ["Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69161", "l": "agmatine + H2O + O2 => H2O2 + N-amidino-(2R)-hydroxypyrrolidine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682826", "l": "LGI1 binds ADAM11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73243", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether = cirsimaritin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632679", "l": "EVC2:EVC binds p-SMO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635843", "l": "GLI translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451366", "l": "Activation of p38MAPK by DSCAM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54030", "l": "a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67897", "l": "a 3'-end uridylyl-adenosine-RNA => a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74197", "l": "(5Z)-3-(3,4-dihydroxyphenyl)-5-[(3,4-dihydroxyphenyl)methylidene]-5-oxo-2,5-dihydrofuran-3-olate => aspulvinone E + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754827", "l": "SARS-CoV-2 M binds TBK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65928", "l": "3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine = 3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632738", "l": "DDIT4 binds 14-3-3 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71485", "l": "L-phenylalanyl-L-methionine + L-tyrosylglycylglycine => H2O + Met-enkephalin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700154", "l": "Active ALK binds SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68469", "l": "(2Z,6Z)-farnesyl diphosphate => (E)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198714", "l": "ERK5 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944650", "l": "miR-214 microRNA binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52774", "l": "6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate => 7,8-dihydroneopterin 3'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73083", "l": "chrysoeriol + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + velutin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46595", "l": "alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167197", "l": "Separation of elongating HIV-1 transcript from template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37225", "l": "1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA => (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62472", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22694", "l": "2,5-dihydroxybenzoate + H2O + NAD(+) => 3-hydroxybenzoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917841", "l": "Acidification of Tf:TfR1 containing endosome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.170", "l": "\"isoflavone 7-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191402", "l": "Reduction of presqualene diphosphate to form squalene (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004583", "l": "dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47506", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => chenodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-593685", "l": "Netrin-4 binds DCC/UNC5A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158357", "l": "factor XIIa binds SERPING1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73308", "l": "H(+)(in) + L-aspartate(out) + phosphate(in) => H(+)(out) + L-aspartate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.12", "l": "\"2,4-diaminopentanoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14067", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O => scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n11", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0005371", "l": "tricarboxylate secondary active transmembrane transporter activity", "d": ["Enables the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635843", "l": "GLI translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72185", "l": "mRNA polyadenylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003941", "l": "L-serine ammonia-lyase activity", "d": ["Catalysis of the reaction: L-serine = pyruvate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24100", "l": "diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride + 2 H(+)", "d": []}, {"i": "EC:3.1.8.2", "l": "\"diisopropyl-fluorophosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008458", "l": "carnitine O-octanoyltransferase activity", "d": ["Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15366", "l": "3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose => 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24307", "l": "(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) <=> (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751040", "l": "PKC phosphorylates G alpha (z) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11637", "l": "NADP(+) + prostaglandin E1 => 15-oxoprostaglandin E1 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74118", "l": "an anthocyanidin + UDP-alpha-D-galactose <=> an anthocyanidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791139", "l": "Expression of SRPR (SRP Receptor subunit alpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931981", "l": "RUNX1 binds ESR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.214786017368347", "identifiers": [{"i": "GO:0016791", "l": "phosphatase activity", "d": ["Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12468", "l": "avenacoside A + H2O = 26-desgluco-avenacoside A + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58408", "l": "NADP(+) + undecan-1-ol = H(+) + NADPH + undecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050247", "l": "raucaffricine beta-glucosidase activity", "d": ["Catalysis of the reaction: H2O + raucaffricine = D-glucose + vomilenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10791", "l": "2-dehydro-D-gluconate + ATP <=> 6-phospho-2-dehydro-D-gluconate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41900", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] = 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.50", "l": "\"pentachlorophenol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63094", "l": "H2O + ilicicolin A epoxide + NADP(+) => H(+) + ilicicolin A + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.968459345787338", "identifiers": [{"i": "GO:0004386", "l": "helicase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009032", "l": "thymidine phosphorylase activity", "d": ["Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102414", "l": "quercetin-3-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) <=> quercetin-3-gentiobioside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72958", "l": "2 Na(+)(out) + nicotinate(out) <=> 2 Na(+)(in) + nicotinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58455", "l": "N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603534", "l": "Unknown caspase cleaves NTRK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858428", "l": "FCAMR binds IgA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55483", "l": "ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29678", "l": "glycerol(in) <=> glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112342", "l": "Inactivation of MAP2K1 by CDK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73942", "l": "desmethyl-dehydrogriseofulvin + S-adenosyl-L-methionine <=> dehydrogriseofulvin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50628", "l": "a 2-(omega-methylsulfanyl)alkylmalate = a 3-(omega-methylsulfanyl)alkylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61601", "l": "[DsbD protein]-disulfide + [protein]-dithiol => [DsbB protein]-dithiol + [protein]-disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725855", "l": "NR3C2 binds NR3C2 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030619", "l": "U1 snRNA binding", "d": ["Binding to a U1 small nuclear RNA (U1 snRNA)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110068", "l": "glucosylglycerate phosphorylase activity", "d": ["Catalysis of the reaction: glucosylglycerate + phosphate = glucose-1-phosphate + D-glycerate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47559", "l": "H2O + taurodeoxycholate <=> deoxycholate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047339", "l": "nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase activity", "d": ["Catalysis of the reaction: hexose 1-phosphate + nucleoside triphosphate = NDP-hexose + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070915", "l": "lysophosphatidic acid receptor activity", "d": ["Combining with the phospholipid derivative lysophosphatidic acid, and transmitting the signal across the membrane by activating an associated G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9660192", "l": "VDR agonists bind VDR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39039", "l": "an omega-oxo fatty acid + H2O + NAD(+) = a dicarboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814153", "l": "ADO oxidises 2AET to HTAU (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33037", "l": "2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13545", "l": "(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] = (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.58", "l": "\"trimethyltridecatetraene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53625", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + tsukubadiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404144", "l": "Parenchymal atROL translocates to HSCs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202375", "l": "Recruitment of ITK to SLP-76 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31571", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 = CO2 + H2O + NADP(+) + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803391", "l": "TP53 binds the PCBP4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30424", "l": "(2E,6E)-farnesyl diphosphate => (+)-delta-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13568", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol <=> 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876789", "l": "CARNMT1 methylates CARN to Anserine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15551", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O => S-methyl-5-thio-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29356", "l": "dUMP + H2O => 2'-deoxyuridine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64764", "l": "S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine = 2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193669", "l": "TRAF6 binds to p75NTR:NRIF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23047", "l": "H(+) + N,N-dihydroxy-L-tyrosine <=> (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675206", "l": "PEA15 binds MAPK monomers and dimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14717", "l": "D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate", "d": []}, {"i": "EC:2.5.1.54", "l": "\"3-deoxy-7-phosphoheptulonate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24227", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) <=> 4-methylcatechol + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655483", "l": "USP1 autocleavage (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196929", "l": "FLAD1 phosphorylates FMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22299", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate <=> (1R,2R,3R)-prephytoene diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983158", "l": "Trimming of peptides in ER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21261", "l": "[thioredoxin]-disulfide + H2O + L-methionine => [thioredoxin]-dithiol + L-methionine (R)-S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10593", "l": "a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030338", "l": "CMP-N-acetylneuraminate monooxygenase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44493", "l": "3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050300", "l": "aminoglycoside 6-kinase activity", "d": ["Catalysis of the reaction: ATP + streptomycin = ADP + 2 H+ + streptomycin 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68982", "l": "7-oxotaurolithocholate + H(+) + NADPH => NADP(+) + tauroursodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.99", "l": "\"arabinan endo-1,5-alpha-L-arabinosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665761", "l": "FMNL3 binds RHOC:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613202", "l": "EGR1 and NAB co-repressors bind EGR1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50196", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798749", "l": "Exocytosis of specific granule lumen proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678854", "l": "S1PR1 binds S1PR1 agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25351", "l": "H2O + L-cysteinyl-tRNA(Pro) = H(+) + L-cysteine + tRNA(Pro)", "d": []}, {"i": "EC:3.6.1.n2", "l": "\"L-cysteinyl-tRNA(Pro)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2167924", "l": "SMAD7:SMURF1 complex binds XPO1 (CRM1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662837", "l": "p-S,T-ADAM17(215-827):Zn2+ cleaves CD163 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49439", "l": "cholate + deoxycholoyl-CoA <=> choloyl-CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.-", "l": "\"Transferring groups other than amino-acyl groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68713", "l": "(2E,6E)-farnesyl diphosphate => (1S,2S,4R)-beta-elemene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70574", "l": "D-glucose(out) + Na(+)(out) <=> D-glucose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21159", "l": "(2R)-2-phosphoglycerate + H2O <=> (R)-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47037", "l": "uridine in 5S rRNA => pseudouridine in 5S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32722", "l": "L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24077", "l": "a 3beta-hydroxy-Delta(5)-steroid + NAD(+) => a 3-oxo-Delta(5)-steroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357483", "l": "RAC1 binds PAK1-3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51408", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801776", "l": "REG3A binds bacterial phospholipids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632412", "l": "PTK2 is recruited to methylated ESR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72880", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate => NH4(+) + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29915", "l": "L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) + UDP-alpha-D-glucose = alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73550", "l": "GTP(out) + UTP(in) <=> GTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75655", "l": "(9Z)-octadecenoate + O2 = (8R)-hydroperoxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047027", "l": "benzyl-2-methyl-hydroxybutyrate dehydrogenase activity", "d": ["Catalysis of the reaction: benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP+ = benzyl 2-methyl-3-oxobutanoate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55812", "l": "a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632887", "l": "TP53 binds the RRM2B gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682020", "l": "MRN complex binds shortened telomeres (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42929", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26326", "l": "(8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine => (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29571", "l": "H(+)(in) + L-idonate(in) = H(+)(out) + L-idonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68342", "l": "(R)-S-sulfopantetheine + phosphate => (R)-4'-phospho-S-sulfopantetheine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26075", "l": "D-glucuronate + H(+) + UDP => H2O + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76070", "l": "(S)-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-methionine <=> (S)-cis-N-methyl-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936380", "l": "Interaction of PIN1 with p-IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29921", "l": "ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53176", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15456", "l": "S-adenosyl-L-methionine + sarcosine <=> H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74861", "l": "H2O + norsalsolinol => dopamine + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-398184", "l": "LARG activation by G alpha 12/13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29133", "l": "H2O + menaquinone-8 + nitrite => menaquinol-8 + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796626", "l": "MIB2 ubiquitinates CFLAR  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68952", "l": "isoscopoletin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + scoparone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102335", "l": "N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP-N-acetyl-D-galactosamine <=> N-acetyl-D-galactosaminyl-alpha-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16035", "l": "CO2 + gibberellin A19 + H2O + succinate => 2-oxoglutarate + gibberellin A44 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71271", "l": "H(+)(in) + thiamine(out) = H(+)(out) + thiamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41254", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62241", "l": "a thymidine(6-4)cytidine in DNA => a thymine-cytidine dinucleotide in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5580292", "l": "Defective CYP11B1 does not oxidise 11DCORT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000433", "l": "SUMOylation of PML with SUMO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928625", "l": "PAKs autophosphorylate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58544", "l": "2 L-ascorbate + N-tetradecanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50360", "l": "(R)-mandelonitrile + O2 = benzoyl cyanide + H2O2", "d": []}, {"i": "EC:1.1.3.49", "l": "\"(R)-mandelonitrile oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70607", "l": "3'-phosphoadenylyl sulfate + 4-ethylphenol = 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.60", "l": "\"glucan 1,4-alpha-maltotetraohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205238", "l": "SHP2 interacts with p-KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000103", "l": "CUBN:AMN binds CBLIF:RCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18619", "l": "ADP + CO2 + phosphoenolpyruvate => ATP + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10150", "l": "deaminohydroxyblasticidin S + NH4(+) => blasticidin S + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218822", "l": "CRK binds BCAR1 and or PXN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20676", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35079", "l": "doxorubicin(in) = doxorubicin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432909", "l": "Interaction of Plectin with Integrin beta 4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52190", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O => 1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61285", "l": "H2O + L-cystine + O2 => (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29517", "l": "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54368", "l": "acetaldehyde + H(+) + pyruvate = acetoin + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209823", "l": "Tyrosine is hydroxylated to dopa (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24241", "l": "A + AMP + 2 H(+) + sulfite => adenosine 5'-phosphosulfate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17876", "l": "an R-cob(III)alamin(out) + ATP + H2O <=> ADP + an R-cob(III)alamin(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9726949", "l": "PTGIR binds PTGIR agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982810", "l": "JAK2 phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19240", "l": "4-carboxymethyl-4-methylbut-2-en-1,4-olide <=> 4-carboxymethyl-3-methylbut-2-en-1,4-olide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3266557", "l": "Factor I cleaves iC3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59942", "l": "2-methyloctadecanoate + CoA + H(+) => 2-methyloctadecanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33455", "l": "4alpha-carboxyzymosterol + NADP(+) = CO2 + NADPH + zymosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132104", "l": "Complement factor B binds to the hydrolyzed form of C3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444476", "l": "FPRL2 receptor binds a wide range of ligands (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21685", "l": "(R)-beta-alanopine + H2O + NAD(+) => beta-alanine + H(+) + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53916", "l": "an acyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009371", "l": "Binding of AP1 transcriptional activator complexes to CCND1 promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623365", "l": "Expression of MYLIP regulated by NR1H2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40044", "l": "ATP + citrate + L-glutamate => ADP + beta-citrylglutamate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113454", "l": "RNA Polymerase III Termination and release of transcribed RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77077", "l": "Capping complex formation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23378", "l": "3-dehydro-D-erythronate + H(+) + NADH => L-threonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48462", "l": "2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate => 1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48999", "l": "3-methylcatechol + O2 <=> 2-hydroxy-6-oxo-2,4-heptadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873919", "l": "Phosphorylation of JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821366", "l": "AKAP8L binds MLL2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810076", "l": "DDO oxidizes D-Asp to OA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371353", "l": "Soluble TNF-α binds TNFR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939039", "l": "PPANT translocates from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046922", "l": "peptide-O-fucosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9817575", "l": "ERO1B oxidizes P4HB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75244", "l": "FASL binds FAS Receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047322", "l": "[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity", "d": ["Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50569", "l": "acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60687", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) <=> (11R)-dihydroartemisinate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40901", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33663", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70304", "l": "beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-octanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58421", "l": "NADP(+) + prenol => 3-methyl-2-butenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45256", "l": "hexadecanoate(out) = hexadecanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3636919", "l": "Defective CHST14 does not transfer SO4(2-) to GalNAc in dermatan or DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58713", "l": "NADH + O2 + rifampicin => H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66141", "l": "acetyl-CoA + octopamine => CoA + H(+) + N-acetyloctopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49327", "l": "(5R,6S)-5,6-epoxi-capsanthin <=> all-trans-capsorubin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60789", "l": "gibberellin A24 + H(+) + O2 => CO2 + gibberellin A9 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57114", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22227", "l": "3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA <=> 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811508", "l": "ING2-bound EP300 acetylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.43", "l": "\"lipid A phosphoethanolamine transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130349", "l": "Generation of CLIP from lip10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73485", "l": "D-lysine(out) + L-ornithine(in) => D-lysine(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004040", "l": "amidase activity", "d": ["Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203712", "l": "eNOS associates with Caveolin-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60506", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) => 1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013009", "l": "RHOA binds effectors at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48934", "l": "CMP + ganglioside GQ1b + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67144", "l": "2-oxoglutarate + jasmonate + O2 = (1R,2R)-12-hydroxyjasmonate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0047661", "l": "amino-acid racemase activity", "d": ["Catalysis of the reaction: an L-amino acid = a D-amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69556", "l": "D-glucose(out) + H(+)(out) = D-glucose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11137", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168640", "l": "Ubiquitinated IkB is degraded (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62968", "l": "(R)-lactate + NADP(+) = H(+) + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.87", "l": "\"endo-cleaving rubber dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60256", "l": "A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] = AH2 + formaldehyde + L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46112", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43268", "l": "ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GM2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482772", "l": "Release of platelet cytosolic components (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2484822", "l": "Kinetochore assembly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47614", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36293", "l": "formaldehyde + H2O + NADP(+) + xanthine => 3-methylxanthine + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114552", "l": "Thrombin-activated PARs activate G12/13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40842", "l": "FAD + H(+) + nonanoyl-CoA <=> (2E)-nonenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23011", "l": "alpha,alpha-trehalose 6-phosphate + H2O <=> D-glucose + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20962", "l": "1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10319", "l": "2-oxoglutarate + O2 + thymine <=> 5-hydroxymethyluracil + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71677", "l": "glycyl-L-leucine(in) + H(+)(in) => glycyl-L-leucine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34546", "l": "N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21841", "l": "N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13016", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70389", "l": "CoA + H(+) + N-octadecanoyl-3-oxosphinganine => 3-oxosphinganine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867613", "l": "PICALM binds R-SNAREs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4086410", "l": "CDK1 phosphorylates BORA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-517674", "l": "p-S158,221-HuR binds mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59671", "l": "D-cellohexaose + O2 <=> D-cellohexaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036332", "l": "placental growth factor receptor activity", "d": ["Combining with placental growth factor (PlGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44597", "l": "a fatty acyl-[ACP] + H2O => a fatty acid + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44936", "l": "(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA = (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247844", "l": "WNT ligands traffic to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449087", "l": "CD4 binds Interleukin-16 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30929", "l": "5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose => 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45150", "l": "3-hydroxy-3-(methylsulfanyl)propanoyl-CoA => 3-(methylsulfanyl)acryloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018742", "l": "epoxide hydrolase B activity", "d": ["Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74034", "l": "L-alanine(in) + L-cysteine(out) <=> L-alanine(out) + L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37856", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA => 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23363", "l": "L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose <=> alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16994", "l": "6 Fe(III)-[cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] => 6 Fe(II)-[cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54405", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O => 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5432825", "l": "HMGB1 binds TLR4:LY96 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68891", "l": "2-methoxybenzoate + ATP + H(+) + NADPH <=> 2-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672951", "l": "Inactive RAFs bind YWHAB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73727", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate = (2S,3R,11R)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32410", "l": "(1R,2S,4S)-neoisodihydrocarveol + NAD(+) <=> (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2730835", "l": "Autophosphorylation of PKC-theta (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189406", "l": "4 PBGs bind to form HMB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68440", "l": "beta-cryptoxanthin + O2 = (3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71364", "l": "17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out) => 17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417843", "l": "P2Y13 binds ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013147", "l": "RAC1 GDIs block activation of RAC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24148", "l": "D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.2.7.6", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.-", "l": "\"With a disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674385", "l": "p-T,Y MAPKs dimerize (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56892", "l": "H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose = NADP(+) + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30962", "l": "9,9'-di-cis-zeta-carotene + a quinone <=> 7,9,9'-tri-cis-neurosporene + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62071", "l": "2-deoxy-D-glucose 6-phosphate + NADP(+) <=> 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75388", "l": "H2O + queuosine 5'-phosphate => D-ribose 5-phosphate + queuine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353524", "l": "XP-C binds to RAD23B forming a heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416530", "l": "FFAR1:FFAR1 ligands activates Gq (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603797", "l": "PEX19:PEX3 binds PEX16 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177934", "l": "EGFR autophosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61567", "l": "a tetracycline + H(+) + NADPH + O2 <=> a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050012", "l": "juglone 3-hydroxylase activity", "d": ["Catalysis of the reaction: 2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62888", "l": "GDP-beta-L-fucose + lactose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64492", "l": "3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] = dehydrocitreoisocoumarin + H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26247", "l": "diphosphate + fusicocca-2,10(14)-diene => geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2672302", "l": "Phosphorylated LEPR Binds SOCS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55706", "l": "ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide => glycine + hydrogen sulfide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199093", "l": "CXADR binds to AMICA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322434", "l": "XIAP dissociates from ub-TLE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114352", "l": "Sequestration of tBID by BCL-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65684", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine = a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71232", "l": "2 Fe(3+)-[Dph3] + NADH => 2 Fe(2+)-[Dph3] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58668", "l": "3-deoxyfructose + NADP(+) = 3-deoxyglucosone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39760", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168768", "l": "JAK2 binds STAT1/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54505", "l": "all-trans-hexaprenyl diphosphate => beta-hexaprene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858500", "l": "CLEC10A binds Tn-MUC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24452", "l": "L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.80", "l": "\"protein-glutamate O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72342", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + guaiacol + H(+) <=> catechol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63571", "l": "beta-casomorphin-7 + H2O <=> beta-casomorphin-6 + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38324", "l": "2 1-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047454", "l": "phaseollidin hydratase activity", "d": ["Catalysis of the reaction: phaseollidin hydrate = H2O + phaseollidin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48004", "l": "1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 = 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53940", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 = 18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48816", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168640", "l": "Ubiquitinated IkB is degraded (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29762", "l": "octanoate(in) <=> octanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14871", "l": "acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40509", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043798", "l": "glycerate 2-kinase activity", "d": ["Catalysis of the reaction: D-glycerate + ATP = 2-phospho-D-glycerate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54242", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23821", "l": "GDP-alpha-D-mannose => GDP-4-dehydro-alpha-D-rhamnose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47260", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0140328", "l": "floppase activity", "d": ["Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.n1", "l": "\"elongation factor 4\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013147", "l": "RAC1 GDIs block activation of RAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30005", "l": "alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19107", "l": "4-aminobutanoate + 2 H(+) + NADH => 4-aminobutanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729437", "l": "SARS-CoV-2 N binds to TRIM25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48751", "l": "D-threitol + NAD(+) <=> D-erythrulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730858", "l": "Autophosphorylation of BTK/ITK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74321", "l": "O-acetyl-(R)-carnitine(out) => O-acetyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.-", "l": "\"With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73360", "l": "ATP + beta-alanine + dopamine => AMP + beta-alanyl-dopamine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59710", "l": "D-maltotrionate + H(+) => D-maltotriono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964759", "l": "Alternative endo-mannosidase I route (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205286", "l": "GRB2:SOS interacts with p-KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57753", "l": "2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH => C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41605", "l": "1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65623", "l": "hexadecanoyl-CoA + sphinga-(4E,8E)-dienine <=> CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59761", "l": "apigenin + UDP-alpha-D-glucose => apigenin 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35480", "l": "(1'S,5'R)-5'-hydroxyaverantin + NAD(+) => (S)-5'-oxoaverantin + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424484", "l": "Phosphorylation of BTK by p-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43417", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38038", "l": "(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate <=> (4Z)-2-oxohept-4-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71835", "l": "estrone 3-sulfate(out) = estrone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.51", "l": "\"4-hydroxyphenylalkanoate adenylyltransferase FadD29\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395320", "l": "Latent TGF-beta-1 binds integrins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70679", "l": "glycine betaine(in) + H(+)(in) = glycine betaine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74802", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427337", "l": "MBD2 binds methylcytosine in chromatin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21087", "l": "chondroitin 4'-sulfate <=> dermatan 4'-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37656", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70232", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+) => (S)-2-benzoylsuccinyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48949", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983696", "l": "The Immunoglobulin of the BCR binds antigen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653514", "l": "USP17L2 deubiquitinates RCE1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25463", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sibirene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850997", "l": "TRIM27 binds PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592436", "l": "Initial activation of proMMP9 by MMPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65234", "l": "3-hydroxydodecanoate + CoA + H(+) => 3-hydroxydodecanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67092", "l": "ATP + docosanoate(in) + H2O = ADP + docosanoate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39639", "l": "(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA = (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42662", "l": "H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose => NAD(+) + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379387", "l": "COMT transfers Met to DA to form 3MT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710354", "l": "GSDME (1-270) binds cardiolipin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72651", "l": "1,6-dihydroxyphenazine N(5)-oxide + NADPH + O2 = 1,6-dihydroxyphenazine N(5),N(10)-dioxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017044", "l": "melanocyte-stimulating hormone activity", "d": ["The action characteristic of melanocyte-stimulating hormone, any of three peptide hormones that are produced by the intermediate lobe of the pituitary gland and, upon receptor binding, cause dispersal of melanosomes in melanophores of poikilothermic vertebrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22749", "l": "4-hydroxy-4-methyl-2-oxoglutarate => 2 pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60613", "l": "1-octanoyl-sn-glycero-3-phosphocholine => 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684140", "l": "ATM phosphorylates RBBP8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665727", "l": "FMNL2 binds CDC42:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420265", "l": "AMY1-3 bind IAPP(34-70) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450474", "l": "MK2 phosphorylates BRF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34195", "l": "2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 = 2 aureusidin 6-O-beta-glucoside + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22889", "l": "(R)-methylmalonyl-CoA => succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6813749", "l": "ALDH1A1 oxidises GA to DGA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5631885", "l": "PRDX1 overoxidizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75834", "l": "5-oxo-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] <=> 5-oxo-18-hydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60953", "l": "(E)-5-hydroxyferulate + S-adenosyl-L-methionine => (E)-sinapate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166726", "l": "Activation of MASPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47780", "l": "a cytidine in 25S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140926", "l": "L-kynurenine transmembrane transporter activity", "d": ["Enables the transfer of L-kynurenine from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009027", "l": "tartrate dehydrogenase activity", "d": ["Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0015562", "l": "efflux transmembrane transporter activity", "d": ["Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875183", "l": "CBL monoubiquitinates activated MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2429719", "l": "MCPH1 sequesters condensin II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42655", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine <=> diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28075", "l": "(2R)-3-sulfopropanediol + H2O + 2 NAD(+) => (2R)-3-sulfolactate + 3 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19124", "l": "an S-substituted glutathione(in) + ATP + H2O <=> ADP + an S-substituted glutathione(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76456", "l": "O-atom dealkylation of dextromethorphan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57784", "l": "1,4-dinitrobenzene + NADH + O2 = 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33034", "l": "H(+) + keto-D-fructose + NADH <=> D-sorbitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034319", "l": "alcohol O-butanoyltransferase activity", "d": ["Catalysis of the reaction: butanoyl-CoA + an alcohol = CoA + a butyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42493", "l": "3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 => 3'-N-debenzoyltaxol + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12501", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) => 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57651", "l": "S-adenosyl-L-methionine + trichosetin <=> equisetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33275", "l": "a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)", "d": []}, {"i": "EC:3.1.1.116", "l": "\"sn-1-specific diacylglycerol lipase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15533", "l": "(2R)-3-sulfolactate + NAD(+) = 3-sulfopyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58373", "l": "(E)-oct-2-en-1-ol + NADP(+) => (2E)-octenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50097", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004933", "l": "mating-type a-factor pheromone receptor activity", "d": ["Combining with the mating-type a-factor pheromone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42707", "l": "hercynine + L-cysteine + O2 <=> H2O + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201603", "l": "Caspase-mediated cleavage of PKC theta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62853", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75551", "l": "2 a (3R)-3-isocyanyl-fatty acyl-[ACP] + ATP + L-lysine + 2 NADPH = AMP + an isonitrile lipopeptide + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22453", "l": "[phosphate](n+1) + n H2O => n H(+) + (n+1) phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13689", "l": "diphosphate + glycerol = glycerol 1-phosphate + H(+) + phosphate", "d": []}, {"i": "EC:2.7.1.79", "l": "\"diphosphate--glycerol phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30754", "l": "ATP + CoA + hexadecanoate <=> AMP + diphosphate + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21920", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72127", "l": "agmatine(in) + H(+)(out) = agmatine(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28018", "l": "enterobactin + 3 H2O = 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853319", "l": "FGFR2 fusions dimerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68919", "l": "ATP + butanoate + H(+) + NADPH <=> AMP + butanal + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5251942", "l": "Hikeshi binds HSP70s:ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74157", "l": "formaldehyde + glycine + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => H2O + oxidized 2[4Fe-4S]-[ferredoxin] + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62663", "l": "2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol <=> (2'R)-atrovenetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379844", "l": "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73733", "l": "(2S,3R,11S)-aszonalenin + diphosphate => (S)-benzodiazepinedione + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111930", "l": "Adenylate cyclase produces cAMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10582", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29171", "l": "a ubiquinol + 2 O2 = a ubiquinone + 2 H(+) + 2 superoxide", "d": []}, {"i": "EC:1.10.3.17", "l": "\"superoxide oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39497", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+) => 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805811", "l": "Release of SEPT4 from mitochondria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848829", "l": "CBL autoubiquitinates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54845", "l": "H(+) + hexan-3-one + NADPH + O2 => ethyl butanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120325", "l": "NuRD complex binding", "d": ["Binding to a NuRD complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36460", "l": "glycyl-L-proline + H2O => glycine + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24407", "l": "(3S)-hydroxy-3-methylglutaryl-CoA <=> acetoacetate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62527", "l": "cytidine(839) in 12S rRNA + S-adenosyl-L-methionine <=> H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70626", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000348", "l": "RANBP2 SUMOylates SP100 with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54583", "l": "a 5'-end dephospho-ribonucleoside-RNA + ATP <=> a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71198", "l": "H(+)(out) + Zn(2+)(out) <=> H(+)(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47085", "l": "4-methylsulfanyl-2-oxobutanoate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032067", "l": "NTRK2 activates RAS signaling through FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-877187", "l": "P2X7 mediates loss of intracellular K+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787447", "l": "TRMU (MTO2, MTU1) transfers a sulfur atom to 5-taurinomethyluridine-34 in tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-996727", "l": "REST recruits the BHC complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11764", "l": "H2O + methylguanidine = methylamine + urea", "d": []}, {"i": "EC:3.5.3.16", "l": "\"methylguanidinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46365", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66457", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698041", "l": "p-STAT5 binds the CDKN1A gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390641", "l": "ADRA1A,B,D bind ADR,NAd (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004906", "l": "type II interferon receptor activity", "d": ["Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65706", "l": "alpha-D-Tyv-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+) => alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-3,6-dideoxy-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15898", "l": "4-acetamidobutanoate + H2O => 4-aminobutanoate + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37809", "l": "1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48366", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372741", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35544", "l": "3-phosphooxypyruvate + H2O => 3-hydroxypyruvate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784189", "l": "JAKs bind LIFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11873", "l": "corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.33", "l": "\"Delta(12) acyl-lipid conjugase (11E,13E-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030562", "l": "rRNA 2'-O-ribose methylation guide activity", "d": ["Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19149", "l": "L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032781", "l": "WWTR1 (TAZ) binds TEAD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62054", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48625", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2 => (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851018", "l": "BTN2A1 binds DC-SIGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672980", "l": "Dissociation of RAS:RAF complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11079", "l": "anthranilate + 3 H(+) + NADH + O2 <=> catechol + CO2 + NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18450", "l": "A + arsenite + H2O => AH2 + arsenate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42820", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 = H2O + 2 NADP(+) + tetracenomycin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607740", "l": "PKC-delta phosphorylates CARD9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55699", "l": "a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O <=> an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65658", "l": "25-hydroxycholest-1,4-dien-3-one + AH2 => A + cholest-1,4-dien-3-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641134", "l": "SMURF2 binds AXIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38305", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+) => 2-amino-2-deoxy-D-gluconate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12950", "l": "D-fuconate => 2-dehydro-3-deoxy-D-fuconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0046995", "l": "oxidoreductase activity, acting on hydrogen as donor, with other known acceptors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen reduces a known acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP, or a quinone or similar compound."]}, {"i": "EC:1.12.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17794", "l": "H2O + L-alanyl-tRNA(Thr) => H(+) + L-alanine + tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22290", "l": "an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose => an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018768", "l": "2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate + H2O = 2-aminobenzoate + cis-2-hydroxypenta-2,4-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706330", "l": "Active FLT3 binds to SOCS6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17963", "l": "H2O + leukotriene A4 => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388831", "l": "Phosphorylation of CD28 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32217", "l": "(6S)-NADHX => (6R)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5229343", "l": "AXIN is phosphorylated in the destruction complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70058", "l": "AH2 + cremeomycin <=> 2-hydroxy-4-methoxybenzoate + A + N2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21842", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983138", "l": "Transport of MHC heterotrimer to ER exit site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5226979", "l": "ADD1:ADD2 binds DMTN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24448", "l": "enterobactin + UDP-alpha-D-glucose = monoglucosyl-enterobactin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31185", "l": "3-oxododecanoyl-CoA + CoA => acetyl-CoA + decanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19668", "l": "6-carboxyhexanoyl-CoA + NAD(+) <=> 6-carboxyhex-2-enoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674022", "l": "BRAP autoubiquitinates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14076", "l": "3-hydroxy-L-glutamate + H(+) <=> 4-amino-3-hydroxybutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48594", "l": "a quinol + CO2 => a quinone + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5688786", "l": "ATXN3 binds RAD23 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53603", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70296", "l": "2-oxoglutarate + 3-sulfino-L-alanine => 3-sulfinopyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43578", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203611", "l": "N-myristoylation of eNOS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5660980", "l": "p-S276-RELA binds RELB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49142", "l": "dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.8", "l": "\"Fas-activated serine/threonine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0017103", "l": "UTP:galactose-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-galactose 1-phosphate + UTP = diphosphate + UDP-D-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57465", "l": "(E)-caffeate + UDP-alpha-D-glucose => 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57293", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O => a guanosine in RNA + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865482", "l": "KMT2A (MLL) binds RUNX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033789", "l": "phenylacetyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2 1,4-benzoquinone + H2O + phenylacetyl-CoA = 2 hydroquinone + phenylglyoxylyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649108", "l": "HTR3A pentamer binds 5HT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72816", "l": "L-lysine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) => L-lysine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37037", "l": "2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-2-aminopentanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59447", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A <=> 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218806", "l": "FYN autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052902", "l": "spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity", "d": ["Catalysis of the reaction: H2O + O2 + spermidine = 3-aminopropanal + H2O2 + putrescine."]}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0042879", "l": "aldonate transmembrane transporter activity", "d": ["Enables the transfer of aldonate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050353", "l": "trimethyllysine dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55478", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine => an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0016714", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor."]}, {"i": "EC:1.14.16.-", "l": "\"With reduced pteridine as one donor, and incorporation of one atom of oxygen\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28869", "l": "H(+)(out) + lactose(out) => H(+)(in) + lactose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38665", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798749", "l": "Exocytosis of specific granule lumen proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20131", "l": "adenine + D-ribose 5-phosphate => AMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980056", "l": "JAG1 binds NOTCH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54302", "l": "n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H(+) => n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63797", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140432", "l": "5'-hydroxyl dinucleotide hydrolase activity", "d": ["Catalysis of the hydrolysis of phosphodiester bonds in 5'OH-RNA according to the reaction 5'OH-RNA + H20 = 5'OH-NpN (dinucleotide) + 5'P-RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35711", "l": "acetate + succinyl-CoA = acetyl-CoA + succinate", "d": []}, {"i": "EC:2.8.3.18", "l": "\"succinyl-CoA:acetate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047692", "l": "ATP deaminase activity", "d": ["Catalysis of the reaction: ATP + H2O = ITP + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937177", "l": "AHR:TCDD binds ARNT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49223", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP <=> CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27802", "l": "(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = all-trans-decaprenyl diphosphate + 7 diphosphate", "d": []}, {"i": "EC:2.5.1.91", "l": "\"all-trans-decaprenyl-diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56737", "l": "H2O + O2 + retinal => H(+) + H2O2 + retinoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70807", "l": "4-deoxy-4-sulfo-D-erythrose = 4-deoxy-4-sulfo-D-erythrulose", "d": []}, {"i": "EC:5.3.1.37", "l": "\"4-deoxy-4-sulfo-D-erythrose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47233", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10787", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22959", "l": "1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71587", "l": "(S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2-oxoglutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5082391", "l": "Trimerization of HSF1 in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52215", "l": "acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022462", "l": "MECP2 mutants R133C ,D121G, R133H and S134F do not bind 5hmC-DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17013", "l": "H(+) + phosphoenolpyruvate = 3-phosphonopyruvate", "d": []}, {"i": "EC:5.4.2.9", "l": "\"phosphoenolpyruvate mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18191", "l": "[(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+) => [(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37267", "l": "H2O + L-alanyl-L-aspartate = L-alanine + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928654", "l": "Clathrin internalises EPH:EFN complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106355", "l": "4-hydroxybenzoate 3-monooxygenase [NADH] activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + H2O + NAD+."]}, {"i": "RHEA:19473", "l": "4-hydroxybenzoate + H(+) + NADH + O2 = 3,4-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964886", "l": "EPSP from shikimate 3-phosphate (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72161", "l": "glutarate(out) + taurocholate(in) => glutarate(in) + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912409", "l": "NOTCH3 mRNA translation controlled by miRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013435", "l": "RHOD auto-activates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003827", "l": "alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61166", "l": "H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP => kaempferol + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18911", "l": "2,4,6-trichloroanisole + S-adenosyl-L-homocysteine => 2,4,6-trichlorophenol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18596", "l": "sphinganine 1-phosphate <=> hexadecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39472", "l": "(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021357", "l": "PRKCI phosphorylates ELF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46661", "l": "H(+) + NADPH + progesterone => 5beta-pregnan-3,20-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944240", "l": "Association of procollagen type III (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805638", "l": "KAT6A acetylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047056", "l": "(S)-canadine synthase activity", "d": ["Catalysis of the reaction: (S)-tetrahydrocolumbamine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-canadine + [oxidized NADPH--hemoprotein reductase] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62465", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O => 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30686", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N-acetyl-D-mannosamine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46560", "l": "episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21631", "l": "17alpha-hydroxyprogesterone + NADPH + O2 <=> acetate + androst-4-ene-3,17-dione + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638006", "l": "ARL3 hydrolyzes GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75476", "l": "D-mannose(out) + n Na(+)(out) => D-mannose(in) + n Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19225", "l": "glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]", "d": []}, {"i": "EC:1.97.1.4", "l": "\"[formate-C-acetyltransferase]-activating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661517", "l": "LUBAC binds OTULIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67044", "l": "A + asnovolin H = AH2 + chermesin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432129", "l": "FGR binds and phosphorylates LRP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198669", "l": "p38MAPK phosphorylates MSK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928654", "l": "Clathrin internalises EPH:EFN complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70223", "l": "(2S)-2-aminobutanoate + 2-oxoglutarate = 2-oxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39687", "l": "(R)-3-hydroxy-(11Z)-octadecenoyl-CoA = (2E,11Z)-octadecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785594", "l": "FANCD2 binds FANCI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67593", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O => (R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41532", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine", "d": []}, {"i": "EC:1.14.16.7", "l": "\"phenylalanine 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70948", "l": "L-tryptophan(in) => L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8857686", "l": "FITM1, FITM2 bind TAGs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24076", "l": "a 3beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)-steroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674022", "l": "BRAP autoubiquitinates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54306", "l": "n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H(+) => n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41633", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865320", "l": "CBFB binds RUNX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32746", "l": "L-homocysteine + O-acetyl-L-serine <=> acetate + H(+) + L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30425", "l": "(+)-delta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28559", "l": "D-fructose 6-phosphate + H2O => D-fructose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694576", "l": "nsp3 binds to nsp7-8 and nsp12-16 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38599", "l": "NADP(+) + nicotinate = nicotinamide + nicotinate-adenine dinucleotide phosphate", "d": []}, {"i": "EC:2.4.99.20", "l": "\"2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62021", "l": "H2O + sitosteryl 3-beta-D-glucoside => D-glucose + sitosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67291", "l": "ATP + 12 H(+) + L-leucine + 8 malonyl-CoA + 9 NADPH + 4 S-adenosyl-L-methionine <=> (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + AMP + 8 CO2 + 8 CoA + diphosphate + 7 H2O + 9 NADP(+) + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004934", "l": "mating-type alpha-factor pheromone receptor activity", "d": ["Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31868", "l": "(S)-2,3-epoxysqualene => baccharis oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28577", "l": "H(+)(in) + sulfate(in) <=> H(+)(out) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173740", "l": "Factor B binds to C3(H2O) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004395", "l": "hexaprenyldihydroxybenzoate methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19536", "l": "2 H(+) + 2 H2O + N(2)-succinyl-L-arginine <=> CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420980", "l": "Activation of Ca permeable AMPA receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109639", "l": "Formation of the closed pre-initiation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14968", "l": "an acyl phosphate + H2O <=> a carboxylate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25593", "l": "2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2", "d": []}, {"i": "EC:2.2.1.9", "l": "\"2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31258", "l": "(2S)-2-acetolactate <=> 3-hydroxy-3-methyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705926", "l": "AR binds AR agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.5", "l": "\"NAD(+) glycohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56325", "l": "(2'-deoxyribonucleoside 5'-methylphosphotriester)-DNA + L-cysteinyl-[protein] => 2'-deoxyribonucleotide-DNA + H(+) + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48561", "l": "H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate => D-ribose 5-phosphate + N(6)-dimethylallyladenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186771", "l": "RNF111 binds SMAD7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39339", "l": "(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71914", "l": "cholate(out) + 2 Na(+)(out) <=> cholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.18", "l": "\"methionyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9716913", "l": "ESR1 binds ESR1 antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004416", "l": "hydroxyacylglutathione hydrolase activity", "d": ["Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68055", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O <=> a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40814", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56957", "l": "ITP + pyruvate => H(+) + IDP + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72016", "l": "acetyl-CoA + 2 AH2 + 9 H(+) + malate + 6 malonyl-CoA + 5 NADPH + 2 S-adenosyl-L-methionine => 2 A + 6 CO2 + 7 CoA + 6 H2O + 5 NADP(+) + 2 S-adenosyl-L-homocysteine + trihazone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75546", "l": "(3R)-3-[(carboxylmethyl)amino]decanoate + H(+) + holo-[ACP] <=> (2E)-decenoyl-[ACP] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60515", "l": "a guanosine in miRNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38936", "l": "cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34271", "l": "2-nitroimidazole + H2O = 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite", "d": []}, {"i": "EC:3.5.99.9", "l": "\"2-nitroimidazole nitrohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354073", "l": "Autophosphorylation of PTK2 at Y397 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18945", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen]", "d": []}, {"i": "EC:1.14.11.2", "l": "\"procollagen-proline 4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667619", "l": "AVPR1A,B,2 bind atosiban (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19159", "l": "2-dehydro-3-deoxy-D-arabinonate + H2O => D-xylonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57253", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP => glycolate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74853", "l": "(R)-salsolinol + H2O => acetaldehyde + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090586", "l": "protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylglucosamine (out) = protein cysteine + N-acetylglucosamine-6-phosphate (in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26243", "l": "diphosphate + elisabethatriene => geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46603", "l": "[HPr protein]-L-serine + ATP <=> [HPr protein]-O-phospho-L-serine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690196", "l": "USP8 deubiquitinates RNF128 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9650473", "l": "SERPING1 is secreted (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793444", "l": "ITCH polyubiquitinates MLKL at K50 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69961", "l": "6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9617595", "l": "SGTA binds mislocalized membrane protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211960", "l": "CYP2U1 19-hydroxylates ARA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205136", "l": "GTP-bound RAC contributes to JNK activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14947", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019978", "l": "interleukin-3 binding", "d": ["Binding to interleukin-3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707645", "l": "HMOX1 gene produces HMOX1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49406", "l": "alpha-D-mannose 1-phosphate + D-mannose => beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75353", "l": "4-oxo-4-(pyridin-3-yl)butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) + methylamine => 2 Fe(III)-[cytochrome c] + H2O + pseudooxynicotine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44996", "l": "(R)-carnitine + acetoacetyl-CoA = CoA + O-3-oxobutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73632", "l": "CTP(out) + dGTP(in) => CTP(in) + dGTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11156", "l": "H2O + L-valine + NADP(+) = 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)", "d": []}, {"i": "EC:1.4.1.8", "l": "\"valine dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938913", "l": "RUNX1 binds ELF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71014", "l": "L-isoleucine(in) + L-phenylalanine(out) <=> L-isoleucine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63673", "l": "(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH => H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786101", "l": "IL4 binds IL4R:JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981892", "l": "Active G alpha (z) binds RGS proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102085", "l": "N-(4-aminobenzoyl)-L-glutamate synthetase activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + L-glutamate + ATP <=> H+ + p-aminobenzoyl glutamate + AMP + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944223", "l": "Association of procollagen type V (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44273", "l": "3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA => 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28287", "l": "a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46361", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58567", "l": "15alpha-stemmadenine + NADP(+) <=> 15alpha-stemmadenine intermediate II + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45131", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5609939", "l": "Defective PGM1 does not isomerise G6P to G1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31084", "l": "H2O + N-acetyl-D-muramoyl-L-alanine => L-alanine + N-acetyl-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49418", "l": "alpha-D-ribose 1,5-bisphosphate + AMP + H(+) => ADP + alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22692", "l": "3-hydroxybenzoate + H(+) + NADH + O2 = 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.24", "l": "\"3-hydroxybenzoate 6-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675910", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65262", "l": "3-hydroxypentacecilide A => verruculide C epoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44254", "l": "1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468040", "l": "Cohesin binds PDS5 and WAPAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70072", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sitosterol => (22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13787", "l": "H2O + itaconyl-CoA => (3S)-citramalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.651613913496419", "identifiers": [{"i": "GO:0016790", "l": "thiolester hydrolase activity", "d": ["Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A."]}, {"i": "EC:3.1.2.-", "l": "\"Thiolester hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43635", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) <=> an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52679", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O <=> [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39607", "l": "(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH = (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33955", "l": "DIBOA + UDP-alpha-D-glucose = DIBOA beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13633", "l": "ATP + L-glutamate + putrescine = ADP + gamma-L-glutamylputrescine + H(+) + phosphate", "d": []}, {"i": "EC:6.3.1.11", "l": "\"glutamate--putrescine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64169", "l": "2-ethyl-L-serine => (2S)-2-aminobutanoate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389532", "l": "PP2A binds CTLA4 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72919", "l": "4-O-demethylbarbatate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28786", "l": "H2O + L-cysteinylglycine <=> glycine + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51868", "l": "dimethylallyl diphosphate + umbelliferone = demethylsuberosin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034700", "l": "allulose 6-phosphate 3-epimerase activity", "d": ["Catalysis of the reaction: D-allulose 6-phosphate = D-fructose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75294", "l": "glyoxylate(in) + oxalate(out) <=> glyoxylate(out) + oxalate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0031871", "l": "proteinase activated receptor binding", "d": ["Binding to a proteinase activated receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0061995", "l": "ATP-dependent protein-DNA complex displacement activity", "d": ["An activity that displaces proteins or protein complexes from DNA, sometimes in a 'wire stripping' fashion, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16275", "l": "a sphingomyelin + CMP + H(+) => an N-acylsphing-4-enine + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66068", "l": "4-methyl-2-oxopentanoate + L-kynurenine = H2O + kynurenate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38382", "l": "(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028724", "l": "AMOT proteins bind YAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029690", "l": "Caspase-6 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196964", "l": "RFK:Mg2+ phosphorylates RIB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392870", "l": "Gs activation by prostacyclin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19929", "l": "[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.12", "l": "\"cellulose synthase (UDP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62028", "l": "H2O + stigmasteryl 3-beta-D-glucoside = D-glucose + stigmasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984689", "l": "Kinesin-7 is a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15949", "l": "(R)-2-hydroxyoctadecanoate + NAD(+) = 2-oxooctadecanoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.98", "l": "\"(R)-2-hydroxy-fatty-acid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31104", "l": "7,8-dihydrofolate + NADP(+) => folate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714691", "l": "RAC3 binds ER effectors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34931", "l": "glutathioselenol + NADPH = glutathione + hydrogenselenide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27286", "l": "(S)-acetoin + NAD(+) = diacetyl + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.304", "l": "\"diacetyl reductase [(S)-acetoin forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56372", "l": "3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 = 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73403", "l": "(2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53903", "l": "ATP + L-threonyl-[myosin light chain] <=> ADP + H(+) + O-phospho-L-threonyl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72840", "l": "ADP(out) + CoA(in) => ADP(in) + CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65272", "l": "chrodrimanin C + H(+) + NADPH + O2 = chrodrimanin H + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798372", "l": "ATM phosphorylates DYRK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022877", "l": "protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381668", "l": "cAMP activates EPAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36534", "l": "(13Z)-docosenoyl-CoA + H(+) + malonyl-CoA <=> (15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62988", "l": "dodecanamide + H2O = dodecanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654425", "l": "Activated FGFR4 binds SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377644", "l": "Release of CSK from SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804379", "l": "PRMT5 binds TTC5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2468040", "l": "Cohesin binds PDS5 and WAPAL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.74", "l": "\"cutinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11336", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.99", "l": "\"3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353243", "l": "Monoubiquitunated PCNA mediates recruitment of the translesion polymerase to the DNA damaged site. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1564169", "l": "Collagen type VIII degradation by MMP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10374", "l": "benzoyl-CoA + CO2 + NADH => CoA + NAD(+) + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64659", "l": "(E)-sinapaldehyde + CoA + NADP(+) <=> (E)-sinapoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28384", "l": "D-glucose 6-phosphate + L-lysine => H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676596", "l": "TRAF3 binds BAFFR:BAFF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198714", "l": "ERK5 translocates to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11789", "l": "H2O + L-aspartate + NAD(+) => H(+) + NADH + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086410", "l": "CDK1 phosphorylates BORA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40591", "l": "decanedioyl-CoA + H2O = CoA + decanedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48716", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76052", "l": "Binding of TFIIIA To type 1 Promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0003984", "l": "acetolactate synthase activity", "d": ["Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981713", "l": "C4b binds to cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59412", "l": "2-oxosuccinamate + H2O = NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803871", "l": "TP53 stimulates SFN expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46389", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55452", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.64", "l": "\"beta-amyrin 6beta-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50049", "l": "ATP + cholate(in) + H2O => ADP + cholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34726", "l": "15-methylhexadecasphing-4-enine 1-phosphate + H2O <=> 15-methylhexadecasphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49857", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62044", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O = (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2464810", "l": "atRAL(membrane) diffuses to atRAL(cytosol) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756494", "l": "CREBBP acetylates SARS-CoV-2 N at K375 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102733", "l": "typhasterol C-23 hydroxylase activity", "d": ["Catalysis of the reaction: typhasterol + O2 + a reduced electron acceptor = castasterone + H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77081", "l": "Formation of the CE:GMP intermediate complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018680", "l": "deethylatrazine monooxygenase activity", "d": ["Catalysis of the reaction: 2 deethylatrazine + O2 = 2 CH3COCH3 + 2 deisopropyldeethylatrazine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64775", "l": "S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine <=> 2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18175", "l": "(4-hydroxyphenyl)acetaldehyde + NH4(+) => (R)-octopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42593", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n7", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030736", "l": "phenol O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202489", "l": "Oligomerization of Bcl10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35319", "l": "H(+) + malonyl-CoA + octadecanoyl-CoA = 3-oxoeicosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15124", "l": "dithioerythritol + thiosulfate <=> cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68042", "l": "(3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+) => (R)-lanthionine ketimine + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23005", "l": "a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205289", "l": "Autophosphorylation of KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16525", "l": "2-dehydro-3-deoxy-D-galactonate + ATP = 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37931", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22616", "l": "2 H(+) + O2 + 2 sulochrin = 2 (2R)-bisdechlorogeodin + 2 H2O", "d": []}, {"i": "EC:1.21.3.5", "l": "\"sulochrin oxidase [(-)-bisdechlorogeodin-forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0020037", "l": "heme binding", "d": ["Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2214351", "l": "PLK1 phosphorylates GORASP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964759", "l": "Alternative endo-mannosidase I route (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11991", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine <=> 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53639", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37254", "l": "cysteamine S-phosphate + H2O <=> cysteamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19494", "l": "D-cellobiose + phosphate => alpha-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4411373", "l": "NLK translocates to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40462", "l": "(2S)-pristanoyl-CoA + O2 <=> (2E)-pristenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73391", "l": "H(+)(in) + phosphate(in) + sulfate(out) = H(+)(out) + phosphate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63865", "l": "O2 + octadecanoate => (2R)-2-hydroperoxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004411", "l": "homogentisate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37417", "l": "1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614544", "l": "Sulfite is oxidized to sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55495", "l": "ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047342", "l": "galactose-1-phosphate thymidylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-galactose 1-phosphate + dTTP = diphosphate + dTDP-D-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9709179", "l": "DPP4 binds DPP4 inhibitors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54179", "l": "a long-chain fatty aldehyde + holo-[ACP] + NADP(+) <=> a long-chain fatty acyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159733", "l": "Furin cleaves pro-factor X to factor X (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645481", "l": "TIFA oligomerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25002", "l": "(E)-phenylacetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22255", "l": "globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> globoside Gb4Cer (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15841", "l": "D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60306", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0000386", "l": "second spliceosomal transesterification activity", "d": ["Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure."]}, {"i": "REACT:R-HSA-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2002460", "l": "P4HB binds Collagen chains (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791137", "l": "Expression of Talin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34301", "l": "2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate => 2'-deamino-2'-hydroxyneamine + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28667", "l": "H(+) + hydroxyacetone + NADH = (S)-propane-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693593", "l": "D-loop extension by DNA polymerases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27882", "l": "2',3'-cyclophospho-CMP + H2O = 3'-CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218820", "l": "Src kinases phosphorylate VAV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483174", "l": "PE is methylated to PC by PEMT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11959", "l": "cholesteryl 3-beta-D-glucoside + H2O <=> cholesterol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55364", "l": "(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 6 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.102", "l": "\"2-alkenal reductase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64377", "l": "8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid => a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13987", "l": "ADP + H(+) + O-phospho-L-homoserine => ATP + L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692738", "l": "HRH2 binds HRH2 antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429699", "l": "CERT1-2 binds ceramide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109700", "l": "AKT2 binds PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74562", "l": "aldosterone <=> aldosterone hemiacetal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40688", "l": "1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol => 1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30734", "l": "butanoyl-CoA + FAD + H(+) <=> (2E)-butenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73111", "l": "S-adenosyl-L-methionine + scutellarein 4'-methyl ether = ladanein + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0018169", "l": "ribosomal S6-glutamic acid ligase activity", "d": ["Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862700", "l": "CMKLR1 binds Resolvin E1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24777", "l": "H2O + pheophorbide a => C-13(2)-carboxypyropheophorbide a + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062065", "l": "box H/ACA snoRNP complex binding", "d": ["Binding to a box H/ACA snoRNP complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029473", "l": "Branching and elongation of mother and daughter filaments (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.107", "l": "\"apo-salmochelin esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032523", "l": "silicon efflux transmembrane transporter activity", "d": ["Enables the transfer of silicon from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74285", "l": "a 2-acyl-sn-glycero-3-phosphocholine + a lipid IIB => a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IIA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653957", "l": "Rag dimer formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047527", "l": "2,3-dihydroxybenzoate-serine ligase activity", "d": ["Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047839", "l": "dATP(dGTP)-DNA purinetransferase activity", "d": ["Catalysis of the reaction: dATP + depurinated DNA = ribose triphosphate + DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034216", "l": "high-affinity thiamine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40976", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O => 2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39045", "l": "docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72453", "l": "a dicarboxylate(out) + dehydroepiandrosterone 3-sulfate(in) => a dicarboxylate(in) + dehydroepiandrosterone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66357", "l": "(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+) => (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49750", "l": "CO2 + 2 H2O + NADP(+) + proviolacein => 2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50612", "l": "decanal + NADP(+) = (2E)-decenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158860", "l": "SULT1A1 dimer sulfonates NHABP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202216", "l": "Phosphorylation of SLP-76 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33003", "l": "(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] = (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2990882", "l": "CDK1 phosphorylates NUP98 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3791319", "l": "NID1 degradation by MMP19 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013889", "l": "TLR3-induced ripoptosome assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004578", "l": "chitobiosyldiphosphodolichol beta-mannosyltransferase activity", "d": ["Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706837", "l": "AR binds AR antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58896", "l": "4-hydroxybutanoate + ATP + CoA = 4-hydroxybutanoyl-CoA + ADP + phosphate", "d": []}, {"i": "EC:6.2.1.56", "l": "\"4-hydroxybutyrate--CoA ligase (ADP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863718", "l": "AGFG1 binds VAMP7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-178208", "l": "SMAD7 binds to SMURF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66728", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15427", "l": "2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX => coproporphyrinogen III + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43705", "l": "ATP + H(+) + tetradecanoate => diphosphate + tetradecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27855", "l": "(2E)-geranyl diphosphate + 4-hydroxybenzoate => 3-geranyl-4-hydroxybenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75847", "l": "9-cis-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = 9-cis-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17235", "l": "L-fuculose => L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004166", "l": "dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0015020", "l": "glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13949", "l": "H(+) + NADP(+) + 2 reduced [rubredoxin] = NADPH + 2 oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16620", "l": "beta-D-glucosyl-(1->3)-D-glucose + phosphate <=> alpha-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77077", "l": "Capping complex formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73752", "l": "(R)-adrenaline(in) + 2 H(+)(out) => (R)-adrenaline(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43468", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = (8Z,10E,14Z)-12-hydroperoxyeicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53899", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11517", "l": "H2O + succinyl-CoA => CoA + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41288", "l": "H2O + N-tetradecanoylsphing-4-enine => sphing-4-enine + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940554", "l": "MMP2 cleaves OPTC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62809", "l": "H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50160", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28252", "l": "acetoacetyl-CoA + CO2 + CoA => acetyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683735", "l": "CHEK2 is recruited to DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799409", "l": "HIPK2 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18697", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) = (4-hydroxyphenyl)acetaldehyde + CO2", "d": []}, {"i": "EC:4.1.1.80", "l": "\"4-hydroxyphenylpyruvate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12126", "l": "CoA + trans-4-coumaroylshikimate => 4-coumaroyl-CoA + shikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50851", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167983", "l": "C-ter TLR7 dimer binds TLR7, TLR8 ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38906", "l": "a sphingomyelin(in) + ATP + H2O <=> a sphingomyelin(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:1990472", "l": "piRNA dual-strand cluster binding", "d": ["Binding to dual-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) where piRNAs originate from both DNA strands via noncanonical transcription."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769177", "l": "NPAS4 stimulates PLK2 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74432", "l": "1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) => 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140031", "l": "phosphorylation-dependent protein binding", "d": ["Binding to a protein upon phosphorylation of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222491", "l": "Lactoferrin scavenges iron ions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45474", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67018", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + L-lysyl-[protein] => a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190877", "l": "Insertion of connexons into the plasma membrane resulting in the formation of hemi-channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047877", "l": "ephedrine dehydrogenase activity", "d": ["Catalysis of the reaction: (1R,2S)-ephedrine + NAD+ = (R)-2-methylimino-1-phenylpropan-1-ol + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936851", "l": "AHRR binds ARNT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50862", "l": "13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75386", "l": "bromide(in) <=> bromide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53909", "l": "(2E)-butenoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390025", "l": "Phosphorylated WTS autophosphorylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33982", "l": "DIBOA beta-D-glucoside + H2O <=> D-glucose + DIBOA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66171", "l": "[protein]-with a C-terminal TM segment(out) + ATP + H2O <=> [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989766", "l": "Expression of CTGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63945", "l": "a fatty acyl-CoA + sphinga-4E,14Z-dienine => an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981931", "l": "RAC1 and CDC42 activate PAK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17031", "l": "allantoate + H(+) => (S)-allantoin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869580", "l": "DEK binds TFAP2A homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74420", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55506", "l": "(5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16948", "l": "(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606807", "l": "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58705", "l": "rifampicin hemiaminal => rifampicin ortho-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102091", "l": "phosphatidylinositol-5-phosphate phosphatase activity", "d": ["Catalysis of the reaction: H2O + a 1-phosphatidyl-1D-myo-inositol 5-phosphate = an 1-phosphatidyl-1D-myo-inositol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673288", "l": "ppDVL binds RAC1:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53705", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O => H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15990", "l": "(R)-mevalonate + CoA + 2 NADP(+) => (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848250", "l": "ACBD6 binds LCFA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37281", "l": "ADP + H(+) + L-alanyl-L-histidine(in) + phosphate => ATP + H2O + L-alanyl-L-histidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10703", "l": "H2O + limonene 1,2-epoxide <=> limonene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.197", "l": "\"high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66741", "l": "ATP + H2O + N-acetyl-L-glutamate(in) => ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.35", "l": "\"gelatinase B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51980", "l": "an L-N,N-dihydroxypolyhomomethionine + H(+) = an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72518", "l": "(R)-carnitine(out) + glutarate(in) <=> (R)-carnitine(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59032", "l": "(Z)-24-ethylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.284", "l": "\"S-(hydroxymethyl)glutathione dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44484", "l": "3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22276", "l": "2-oxoaldehyde + H2O + NAD(+) = a 2-oxocarboxylate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.23", "l": "\"2-oxoaldehyde dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022870", "l": "MOBP gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74728", "l": "acetyl-CoA + 10 H(+) + holo-[polyketide synthase] + 5 malonyl-CoA + 5 NADPH => 5 CO2 + 6 CoA + dodecapentaneoyl-[polyketide synthase] + 5 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52962", "l": "hyocholoyl-24-O-(beta-D-glucuronate) + UDP => hyocholate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693593", "l": "D-loop extension by DNA polymerases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10226", "l": "ADP + H(+) + pyridoxal 5'-phosphate => ATP + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035248", "l": "alpha-1,4-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008296", "l": "3'-5'-DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule."]}, {"i": "REACT:R-HSA-9023943", "l": "MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18970", "l": "a long-chain fatty acid + H(+) + hnu => a long-chain alkane + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9734730", "l": "ORC1 translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11428", "l": "beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9691174", "l": "RAC1 binds effectors at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14390", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28689", "l": "orotate + ubiquinol-8 => (S)-dihydroorotate + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46358", "l": "18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + octadecanoate + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13378", "l": "alpha-D-glucose 1-phosphate + ATP => ADP + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71176", "l": "2 chloride(out) + glycine betaine(out) + 3 Na(+)(out) => 2 chloride(in) + glycine betaine(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38239", "l": "(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12420", "l": "ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.144", "l": "\"tagatose-6-phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70753", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944242", "l": "Association of procollagen type XXVII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851298", "l": "GPR143 binds L-Dopa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72924", "l": "O2 + proatranorin II + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52826", "l": "(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => (1R,4R)-dihydrocarvone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57320", "l": "acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] = CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171026", "l": "Guanine nucleotide exchange on RAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56569", "l": "globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine => globoside IV3GalNAc-Gb4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45134", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13041", "l": "L-dopachrome = 5,6-dihydroxyindole-2-carboxylate", "d": []}, {"i": "EC:5.3.3.12", "l": "\"L-dopachrome isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008061", "l": "chitin binding", "d": ["Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22731", "l": "H(+) + L-seryl-tRNA(Sec) + selenophosphate <=> L-selenocysteinyl-tRNA(Sec) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110011", "l": "Binding of Grb10 to the insulin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28685", "l": "iminosuccinate + ubiquinol-8 => L-aspartate + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42254", "l": "3-oxoheptanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17289", "l": "beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate", "d": []}, {"i": "EC:3.1.3.46", "l": "\"fructose-2,6-bisphosphate 2-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416530", "l": "FFAR1:FFAR1 ligands activates Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618331", "l": "HDAC6 deacetylates microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373074", "l": "Receptor CCR9  binds CCL25 ligand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45098", "l": "(9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18501", "l": "ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.71", "l": "\"Delta(24(24(1)))-sterol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23307", "l": "atropine + H2O <=> H(+) + tropate + tropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69474", "l": "a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + H(+) + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937613", "l": "CRHBP binds CRH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69917", "l": "guanosine(in) + 2 Na(+)(in) => guanosine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16027", "l": "an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA => an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176318", "l": "Loading of claspin onto DNA during replication origin firing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102096", "l": "decaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate:dTDP-alpha-L-rhamnose rhamnosyltransferase activity", "d": ["Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol <=> dTDP(3-) + alpha-L-Rhap-(1->3)-alpha-D-GlcpNAc-1-diphospho-trans,octacis-decaprenol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021050", "l": "HSBP1 oligomer binds ESRs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497866", "l": "Peroxynitrite can oxidise BH4 to the BH3 radical (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39973", "l": "2-aminobut-2-enoate => 1-aminocyclopropane-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11909", "l": "H2O + nonane-4,6-dione => butanoate + H(+) + pentan-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9609310", "l": "β-blockers bind ADRB1,2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25423", "l": "3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O <=> 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63692", "l": "alcohol glucuronate acceptor + UDP-alpha-D-glucuronate = a beta-D-glucuronoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948066", "l": "K63polyUb-IRAK1 dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794008", "l": "LUBAC binds CFLAR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11475", "l": "an N-methyl-L-amino acid + H2O + O2 <=> an L-alpha-amino acid + formaldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34890", "l": "selenate(in) <=> selenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951966", "l": "EP300 acetylates RUNX3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68509", "l": "(2E,6E)-farnesyl diphosphate => (Z)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549304", "l": "OCT3 mediates renal clearance of organic cations (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67476", "l": "dimethylallyl diphosphate + L-glutamate = diphosphate + prekainate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70792", "l": "H(+)(in) + L-ornithine(out) => H(+)(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56812", "l": "2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 = 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate", "d": []}, {"i": "EC:1.14.20.15", "l": "\"L-threonyl-[L-threonyl-carrier protein] 4-chlorinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59537", "l": "ATP + butanoyl-CoA + hydrogencarbonate => (2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696358", "l": "TREM,CD300 binds lipids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54277", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 => (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.2.2", "l": "\"dihydropyrimidinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36535", "l": "docosanoyl-CoA + sphinganine = CoA + H(+) + N-docosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43227", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15323", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35255", "l": "ATP + H2O + lipid A-core(in) = ADP + H(+) + lipid A-core(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23049", "l": "(S)-3-hydroxybutanoate + 2-oxoglutarate => (R)-2-hydroxyglutarate + acetoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3318415", "l": "ATF2 acetylates histone H2B, H4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008738", "l": "L-fuculose-phosphate aldolase activity", "d": ["Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18472", "l": "an acyl-CoA + L-glutamine <=> an N(2)-acyl-L-glutamine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008332", "l": "low voltage-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759920", "l": "GATA4 binds the BMP4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008470", "l": "isovaleryl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25280", "l": "3',5'-cyclic AMP + H2O <=> AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73970", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692539", "l": "HRH1 binds HRH1 inverse agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909732", "l": "Phosphorylation of STAT2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21766", "l": "biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase] => heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70111", "l": "6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39359", "l": "(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48714", "l": "2 Fe(3+) + 2 H2O => 2 Fe(2+) + 2 H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1369052", "l": "ABCAs mediate lipid influx (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53608", "l": "4-hydroxyestrone + O2 = (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4647593", "l": "EP400 binds CDKN1A promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70545", "l": "3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19126", "l": "glyoxylate + L-serine => 3-hydroxypyruvate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53678", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437230", "l": "L1-FGFR cis-heterodimerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50852", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166220", "l": "FA anion diffuses laterally to UCP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60779", "l": "2-oxoglutarate + gibberellin A12 + O2 <=> CO2 + gibberellin A15 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:1901702", "l": "salt transmembrane transporter activity", "d": ["Enables the transfer of salt from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58076", "l": "1-(11Z-eicosenoyl)-glycerol + H2O = (11Z)-eicosenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68603", "l": "ORC5 binds ORC2:ORC3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52770", "l": "2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate => 2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42970", "l": "2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(56) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373724", "l": "Nephrin binds NCK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8943279", "l": "GGT dimers hydrolyse GSH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047206", "l": "UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA(Ala) = UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine + tRNA(Ala)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31400", "l": "all-trans-4,4'-diapophytofluene + FAD + H(+) => all-trans-4,4'-diapo-zeta-carotene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161282", "l": "Elastic fibres bind associated proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43028", "l": "L-cysteate = 2-aminoprop-2-enoate + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050358", "l": "tropinone reductase activity", "d": ["Catalysis of the reaction: NADP+ + pseudotropine = H+ + NADPH + tropinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56952", "l": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928641", "l": "PAK binds RAC and bPIX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015593", "l": "allose transmembrane transporter activity", "d": ["Enables the transfer of allose from one side of a membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56179", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O <=> 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54746", "l": "18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23377", "l": "L-threonate + NAD(+) => 3-dehydro-D-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849094", "l": "ARHGAP35 binds RASA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58841", "l": "cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37786", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61392", "l": "ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404200", "l": "IGF1,2 binds IGF1R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47324", "l": "(S)-3-amino-3-phenylpropanoate + pyruvate = 3-oxo-3-phenylpropanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694442", "l": "CNIH2,3 bind GRIA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912359", "l": "HES1 binds TLE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50266", "l": "26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70266", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate <=> 1D-myo-inositol 1,3,4,6-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40264", "l": "(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) => 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17954", "l": "3-hydroxyanthranilate + O2 => (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682983", "l": "ATM phosphorylates WHSC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13145", "l": "4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate = alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine", "d": []}, {"i": "EC:2.4.1.320", "l": "\"1,4-beta-mannosyl-N-acetylglucosamine phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70776", "l": "6-sulfo-D-quinovose + FMNH2 + O2 => 6-dehydro-D-glucose + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662773", "l": "ADAM17 binds Zn2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071077", "l": "adenosine 3',5'-bisphosphate transmembrane transporter activity", "d": ["Enables the transfer of adenosine 3',5'-bisphosphate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43585", "l": "H2O + iminoarginine => 5-guanidino-2-oxopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791323", "l": "TP53 stimulates BCL2L14 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38404", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034864", "l": "2,4,4-trimethylpentanal dehydrogenase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethylpentanal + H2O = 2,4,4-trimethylpentanoate + 3 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74354", "l": "2 (S)-lactate(in) + prostaglandin E3(out) <=> 2 (S)-lactate(out) + prostaglandin E3(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637605", "l": "PstS1 binds MRC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75843", "l": "ergothioneine(out) + Na(+)(out) = ergothioneine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74715", "l": "Autophosphorylation of insulin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41329", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0141054", "l": "histone H2B ubiquitin ligase activity", "d": ["Catalysis of the transfer of ubiquitin to a histone H2B substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65326", "l": "chrodrimanin B + CoA => acetyl-CoA + chrodrimanin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45599", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050177", "l": "phenylpyruvate decarboxylase activity", "d": ["Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24969", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => H2O + 2 oxidized [adrenodoxin] + secalciferol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621356", "l": "PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450975", "l": "isocitrate <=> citrate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12605", "l": "D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2", "d": []}, {"i": "EC:2.2.1.7", "l": "\"1-deoxy-D-xylulose-5-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1461982", "l": "Alpha-defensin dimers multimerize to form a pore complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175250", "l": "Suicidal integration leading to smaller circles of viral DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32275", "l": "4-(phosphooxy)-L-threonine + NAD(+) = 3-amino-2-oxopropyl phosphate + CO2 + NADH", "d": []}, {"i": "EC:1.1.1.262", "l": "\"4-hydroxythreonine-4-phosphate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32972", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381203", "l": "XBP(S) mRNA is translated and XBP1(S) translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75270", "l": "D-arabinose + NADP(+) <=> D-arabinono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047889", "l": "ferredoxin-nitrate reductase activity", "d": ["Catalysis of the reaction: nitrite + H2O + 2 oxidized ferredoxin = nitrate + 2 reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035514", "l": "Defective ALG9 does not add the last mannose to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102627", "l": "parthenolide 3beta-hydroxylase activity", "d": ["Catalysis of the reaction: parthenolide + NADPH + O2 + H+ <=> 3beta-hydroxyparthenolide + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68651", "l": "2 L-cysteine <=> H(+) + hydrogen sulfide + L-lanthionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426566", "l": "Interaction of DAP12 and CLM7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20188", "l": "a CMP-N-acyl-beta-neuraminate + H2O <=> an N-acylneuraminate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75776", "l": "(6Z,9Z,12Z)-octadecatrienoate + H2O => (10S)-hydroxy-(6Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73770", "l": "cyclo(L-tryptophyl-L-alanyl) + dimethylallyl diphosphate <=> diphosphate + preechinulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35194", "l": "noranthrone + O2 <=> H2O + norsolorinic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24904", "l": "5'-phosphoguanylyl(3'->5')guanosine + H(+) => 3',3'-c-di-GMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102847", "l": "1-18:3-2-16:2-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332235", "l": "CBL binds TGFBR2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56789", "l": "apo-[corrinoid adenosyltransferase] + cob(II)alamin => cob(II)alamin-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621352", "l": "CLEC6A binds alpha-mannan in fungal cell walls (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813749", "l": "ALDH1A1 oxidises GA to DGA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446212", "l": "Flipping of the N-glycan precursor to inside the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9615249", "l": "ARBs bind AGRT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186786", "l": "Autophosphorylation of PDGF beta receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21040", "l": "CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.2.7.4", "l": "\"anaerobic carbon-monoxide dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612672", "l": "ERBB4s80:ESR1 binds ERBB4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52209", "l": "alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35409", "l": "4'-methoxyisoflavan-2',4,7-triol => H2O + medicarpin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16692", "l": "D-glucose 6-phosphate + H2O <=> D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13191", "l": "3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14460", "l": "glyoxylate + H2O + pentanoyl-CoA <=> 3-propylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001165", "l": "RNA polymerase I cis-regulatory region sequence-specific DNA binding", "d": ["Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase I. RNA polymerase I elements are referred to either enhancers or upstream control element (UCE, or alternately referred to as the upstream element)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17668", "l": "L-lysyl-[protein] + octanoyl-[ACP] <=> H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13139", "l": "cyclolaudenol + H(+) + S-adenosyl-L-homocysteine => cycloartenol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625421", "l": "The anterograde IFT train dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032770", "l": "Translocation of YAP1 to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807585", "l": "BPI binds LPS on the bacterial surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13547", "l": "(3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20326", "l": "N-hydroxy-4-acetylaminobiphenyl => N-acetoxy-4-aminobiphenyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21221", "l": "L-dopa + O2 => 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37351", "l": "cytidine 2'-phosphate + H2O = cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209298", "l": "BSK is phosphorylated and activated by phosphorylated HEP kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674531", "l": "AAMP binds EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48427", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852337", "l": "GTSE1 binds TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17905", "l": "(R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47349", "l": "a butanoate ester + H2O => an aliphatic alcohol + butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209332", "l": "LGS dissociates from the PYGO complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64392", "l": "a dipeptide(out) + H(+)(out) = a dipeptide(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761841", "l": "AcK-NFE2L2-dependent SLC7A11 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10271", "l": "2-dehydro-3-deoxy-D-glucarate <=> 2-hydroxy-3-oxopropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39012", "l": "a triacyl-sn-glycerol(in) => a triacyl-sn-glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050155", "l": "ornithine(lysine) transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-ornithine = H2O + L-glutamate + 3,4-dihydro-2H-pyrrole-2-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37597", "l": "1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65776", "l": "chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114553", "l": "Activation of conventional Protein Kinase C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9737780", "l": "MTTP binds lomitapide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15573", "l": "N-acetylserotonin + S-adenosyl-L-methionine = H(+) + melatonin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.4", "l": "\"acetylserotonin O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71041", "l": "L-methionine(out) + L-phenylalanine(in) => L-methionine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66275", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168637", "l": "CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22083", "l": "H(+) + NADH + O2 + quinolin-2-ol <=> H2O + NAD(+) + quinoline-2,8-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32665", "l": "5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine => 5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0004418", "l": "hydroxymethylbilane synthase activity", "d": ["Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21269", "l": "(R)-canadine + 2 NADP(+) => berberine + H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63411", "l": "6-chloropyridine-2,3,5-triol + FADH2 + O2 <=> 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14544", "l": "choloyl-CoA + H2O <=> cholate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451366", "l": "Activation of p38MAPK by DSCAM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16873", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943279", "l": "GGT dimers hydrolyse GSH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36771", "l": "beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.308", "l": "\"GDP-Fuc:beta-D-Gal-1,3-alpha-D-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,2-fucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869568", "l": "NPM1 binds TFAP2A homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71351", "l": "androsterone 3alpha-sulfate(out) + 2 Na(+)(out) = androsterone 3alpha-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030374", "l": "nuclear receptor coactivator activity", "d": ["A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684169", "l": "G6B binds PTPN6,PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17327", "l": "(S)-2-succinylamino-6-oxoheptanedioate + CoA => (S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50494", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679266", "l": "Beclin-1 complex translocates to the ER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54602", "l": "2-hydroxyoctanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21277", "l": "D-arabinitol + NADP(+) => D-xylulose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54336", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75512", "l": "acetyl-CoA + S-benzyl-L-cysteine => CoA + H(+) + N-acetyl-S-benzyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24808", "l": "(2S)-2-acetolactate + thiamine diphosphate <=> 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18860", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180622", "l": "Vpr binds nucleoporins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706399", "l": "RHOBTB3 hydrolyzes ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38054", "l": "2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA <=> 1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52555", "l": "3-dehydro-L-erythronate + ATP <=> 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003974", "l": "UDP-N-acetylglucosamine 4-epimerase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264622", "l": "Cho is acetylated to AcCho by CHAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37764", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA => 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8856945", "l": "PP2A methylation by LCMT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2262775", "l": "Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44760", "l": "2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008686", "l": "3,4-dihydroxy-2-butanone-4-phosphate synthase activity", "d": ["Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140856", "l": "histone H2AK13 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-13 residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371518", "l": "SIRT1 binds to HSF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69394", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028724", "l": "AMOT proteins bind YAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33141", "l": "L-alanine(in) + L-aspartate(out) => L-alanine(out) + L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33349", "l": "glyoxylate + NH4(+) => 2-iminoacetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14111", "l": "1-pyrroline-5-carboxylate + 2 H(+) + NADPH => L-proline + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33729", "l": "a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950533", "l": "Expression of Ras-related protein Ral-A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53043", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25236", "l": "N-acetyl-alpha-neuraminate <=> N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62710", "l": "4-(indol-3-yl)butanoyl-beta-D-glucose + UDP => (indol-3-yl)butanoate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214418", "l": "REL binds to monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12549", "l": "2-cis,4-trans-xanthoxin + NAD(+) => 2-cis-(+)-abscisic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19394", "l": "L-lysine + pyruvate => (S)-2-amino-6-oxohexanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682967", "l": "WHSC1 binds DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62403", "l": "(1R,2S)-ephedrine + NAD(+) <=> (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67668", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11711", "l": "H2O + IMP + NAD(+) <=> H(+) + NADH + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31121", "l": "(2E)-2-methylbut-2-enoyl-CoA + H2O => (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2152276", "l": "Secretion of transmembrane collagens (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508513", "l": "PTK2B binds JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1671687", "l": "PRLR activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678998", "l": "Endosomal TLRs pass through the Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83788", "l": "Binding of TFIIIC to Type 2 promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047504", "l": "(-)-menthol dehydrogenase activity", "d": ["Catalysis of the reaction: (-)-menthol + NADP+ = (2S,5R)-menthone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36842", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11634", "l": "A + H(+) + hydrogenselenide + L-alanine => AH2 + L-selenocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.40", "l": "\"pyruvate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450187", "l": "TAK1 is activated within the TAK1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71935", "l": "glycocholate(out) + 2 Na(+)(out) = glycocholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65971", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O <=> 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420274", "l": "GIP receptor binds gastric inhibitory peptide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51768", "l": "2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate = 4-prenylphlormethylbutanophenone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618863", "l": "CaMKK binds activated calmodulin in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015156", "l": "melibiose transmembrane transporter activity", "d": ["Enables the transfer of melibiose from one side of a membrane to the other. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose and occurs as a constituent of the trisaccharide raffinose or in the exudates and nectaries of a number of plants."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13248", "l": "D-threo-isocitrate <=> glyoxylate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18558", "l": "1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA => 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018697", "l": "carbonyl sulfide nitrogenase activity", "d": ["Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = hydrogen sulfide + carbon monoxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683670", "l": "Protein E forms a homopentamer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72073", "l": "H(+) + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide => L-histidyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39738", "l": "3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089710", "l": "endocytic targeting sequence binding", "d": ["Binding to a endocytic signal sequence, a specific peptide sequence, of 4-6 amino acids with an essential tyrosine (Y), found on cytoplasmic tails of some cell surface membrane proteins, which directs internalization by clathrin-coated pits."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.093101469280398", "identifiers": [{"i": "GO:0003872", "l": "6-phosphofructokinase activity", "d": ["Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20532", "l": "2-cis-(+)-abscisic aldehyde + H2O + O2 <=> 2-cis-(+)-abscisate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49867", "l": "(+)-dehydrodiconiferyl acid + 2 a quinone + H2O <=> (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351871", "l": "Caspase-mediated cleavage of Z0-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727607", "l": "MME:Zn2+ binds sacubitrilat (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.9", "l": "\"isotuberculosinol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047562", "l": "3-hydroxyaspartate aldolase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxy-L-aspartate = glycine + glyoxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418662", "l": "Src activation following P2Y purinoceptor activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948524", "l": "PTENP1 mRNA binds miR-19b RISC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75891", "l": "holothin + pseudomonoyl-CoA C = CoA + pseudomonic acid C--holothin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74891", "l": "CO2(out) = CO2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265177", "l": "Exocyst complex formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9718379", "l": "GNRHR binds chemical antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602473", "l": "Autocatalytic activation of MMP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13515", "l": "H(+) + NADH + orotate => (S)-dihydroorotate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63430", "l": "ADP + D-glucose 6-phosphate + H(+) => ATP + H2O + levoglucosan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51592", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene = benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9650473", "l": "SERPING1 is secreted (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53028", "l": "lithocholate + UDP-alpha-D-glucuronate = H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65878", "l": "1-hydroxy-5alpha-androstan-3,17-dione => 5alpha-androst-1-ene-3,17-dione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983138", "l": "Transport of MHC heterotrimer to ER exit site (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69121", "l": "glyoxylate + L-phenylalanine => 3-phenylpyruvate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035870", "l": "dITP diphosphatase activity", "d": ["Catalysis of the reaction: dITP + H2O = dIMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015069", "l": "scyllo-inosamine-4-phosphate amidinotransferase activity", "d": ["Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32879", "l": "(1R,4R,5R)-5-hydroxycamphor + NAD(+) = (1R,4R)-bornane-2,5-dione + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.327", "l": "\"5-exo-hydroxycamphor dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48640", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23969", "l": "(E)-coniferaldehyde + H2O + NAD(+) => (E)-ferulate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.25", "l": "\"inositol-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052650", "l": "NADP-retinol dehydrogenase activity", "d": ["Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32165", "l": "AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine => ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35113", "l": "2,5-didehydro-D-gluconate + H(+) + NADPH => 2-dehydro-L-idonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028583", "l": "Phosphorylation of YAP by LATS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38585", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20793", "l": "ATP + L-lysine + tRNA(Lys) => AMP + diphosphate + L-lysyl-tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306876", "l": "NLRP3 activation by small molecules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17165", "l": "alpha-D-galactose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-D-galactose", "d": []}, {"i": "EC:2.7.7.32", "l": "\"galactose-1-phosphate thymidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70542", "l": "GDP-beta-L-fucose + L-threonyl-[EGF-like domain protein] <=> 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805126", "l": "AURKB phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58759", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12930", "l": "2-oxoglutarate + acetyl-CoA + H2O => (2R)-homocitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189488", "l": "UROS transforms HMB to URO3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047452", "l": "protoaphin-aglucone dehydratase (cyclizing) activity", "d": ["Catalysis of the reaction: protoaphin aglucone = H2O + xanthoaphin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191830", "l": "snRNP nuclear import and release (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23625", "l": "a 5,6-dihydrouridine in tRNA + NADP(+) => a uridine in tRNA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70262", "l": "AMP(out) + phosphate(in) <=> AMP(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55440", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35594", "l": "H2 + n sulfur <=> H(+) + hydrogen sulfide + (n-1) sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14862", "l": "(S)-dihydroorotate + NADP(+) => H(+) + NADPH + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030109", "l": "HLA-B specific inhibitory MHC class I receptor activity", "d": ["Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035730", "l": "S-nitrosoglutathione binding", "d": ["Binding to S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617927", "l": "FOXO4 binds ATXN3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036130", "l": "prostaglandin H2 endoperoxidase reductase activity", "d": ["Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12048", "l": "3-oxoadipate + succinyl-CoA = 3-oxoadipyl-CoA + succinate", "d": []}, {"i": "EC:2.8.3.6", "l": "\"3-oxoadipate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5681980", "l": "ATG12 binds ATG7 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52964", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate = H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674385", "l": "p-T,Y MAPKs dimerize (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164840", "l": "ADP and Pi bind to ATPase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57694", "l": "2 cob(I)inamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein] => 2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56810", "l": "adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate => ATP + cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71983", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + fusoxypene B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51261", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] => (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0030696", "l": "tRNA (m5U54) methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from a donor to the C5 atom of the uridine residue at position 54 in a tRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086410", "l": "CDK1 phosphorylates BORA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52193", "l": "(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54771", "l": "[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine <=> [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35748", "l": "(2E,6E)-farnesyl diphosphate => 7-epizingiberene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171106", "l": "LDLR:LDL complex => LDLR + LDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38464", "l": "a 1-acyl-sn-glycerol + an acyl-CoA => a 1,2-diacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047971", "l": "guanidinobutyrase activity", "d": ["Catalysis of the reaction: 4-guanidinobutanoate + H2O = 4-aminobutanoate + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028598", "l": "Phosphorylation of YAP by LATS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44306", "l": "a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173626", "l": "Activation of C1r (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20675", "l": "4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59339", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene + A <=> AH2 + demethylspheroidene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55237", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O => (9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58194", "l": "dihydrobisanhydrobacterioruberin + diphosphate => dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990412", "l": "hercynylselenocysteine lyase activity (selenoneine-forming)", "d": ["Catalysis of the reaction: hercynylselenocysteine + 2H+ = selenoneine + pyruvate + ammonium."]}, {"i": "RHEA:42696", "l": "H2O + hercynylselenocysteine = NH4(+) + pyruvate + selnoneine thione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51998", "l": "a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70434", "l": "2 H(+)(out) + Li(+)(in) <=> 2 H(+)(in) + Li(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3221982", "l": "BANP binds TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18575", "l": "chelirubine + H2O2 => dihydrochelirubine + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36450", "l": "ATP + glycyl-L-proline(out) + H2O <=> ADP + glycyl-L-proline(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218805", "l": "PKC autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23721", "l": "ATP + hydrogencarbonate + propanoyl-CoA => (S)-methylmalonyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664867", "l": "NBR1 binds MAP1LC3B (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52651", "l": "H2O + L-arabino-1,4-lactone 5-phosphate <=> 5-phospho-L-arabinonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73893", "l": "ADP + gamma-L-glutamylspermidine + H(+) + phosphate => ATP + L-glutamate + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814555", "l": "Integrator complex processes the 3' end of snRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034802", "l": "branched-chain dodecylbenzene sulfonate monooxygenase activity", "d": ["Catalysis of the reaction: branched-chain dodecylbenzene sulfonate + 1/2 O2 + H+ = sulfurous acid + branched-chain dodecyl-4-hydroxy-benzene + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167133", "l": "Activation of GT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56891", "l": "UDP-4-dehydro-6-deoxy-alpha-D-glucose <=> UDP-4-dehydro-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14369", "l": "2-phosphoglycolate + H2O = glycolate + phosphate", "d": []}, {"i": "EC:3.1.3.18", "l": "\"phosphoglycolate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012835", "l": "GDIs block activation of RHOA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24763", "l": "H(+) + L-dopa + NADH <=> 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.3.-", "l": "\"With reduced pteridine as one donor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250947", "l": "B-WICH complex binds rDNA promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204861", "l": "Interaction of Tie2 and Shc1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75927", "l": "cyclohexylamine + H2O + NAD(+) = cyclohexanone + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46487", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11063", "l": "ATP + L-isoleucine + tRNA(Ile) <=> AMP + diphosphate + L-isoleucyl-tRNA(Ile)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21582", "l": "(R)-acetoin + CO2 => (2S)-2-acetolactate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13129", "l": "cis-4-coumarate + UDP-alpha-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.209", "l": "\"cis-p-coumarate glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52559", "l": "3-dehydro-D-erythronate + ATP <=> 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693243", "l": "RHOD translocates to the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67283", "l": "(2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione <=> (1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102572", "l": "N-glutamylanilide hydrolase activity", "d": ["Catalysis of the reaction: N5-phenyl-L-glutamine + H2O = L-glutamate + aniline + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40169", "l": "(2E)-hexadecenoyl-CoA + H2O2 => hexadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032577", "l": "phosphatidylcholine:cardiolipin O-linoleoyltransferase activity", "d": ["Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69023", "l": "L-aspartate + NADPH + O2 <=> H2O + N-hydroxy-L-aspartate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052588", "l": "diacetyl reductase ((S)-acetoin forming) activity", "d": ["Catalysis of the reaction: (S)-acetoin + NAD+ = diacetyl + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050292", "l": "steroid 9-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + O2 + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39777", "l": "17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40023", "l": "9alpha-copalyl diphosphate + H2O = diphosphate + syn-copalol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65295", "l": "2 ATP + butan-2-one + 3 H2O + hydrogencarbonate <=> 3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813740", "l": "GDE1 hydrolyzes GroPIns (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29726", "l": "glyoxylate(in) <=> glyoxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65287", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate <=> 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Thr-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56001", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15228", "l": "alpha-D-glucose 1-phosphate + dTTP + H(+) <=> diphosphate + dTDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047922", "l": "gentisate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2,5-dihydroxybenzoate + O2 = 3-maleylpyruvate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381087", "l": "Dimerization of PERK (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928657", "l": "MMP2,9 cleave EPHB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74859", "l": "dopamine + formaldehyde = H2O + norsalsolinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863472", "l": "DAB2 binds LRP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047848", "l": "dephospho-[reductase kinase] kinase activity", "d": ["Catalysis of the reaction: ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] = ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66086", "l": "H2O + kynurenate + L-aspartate => L-kynurenine + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11939", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + trans-resveratrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53813", "l": "cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20521", "l": "(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.30", "l": "\"3-hydroxybutyrate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14946", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102588", "l": "cyanidin 3-O-glucoside 6''-O-malonyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + malonyl-CoA <=> cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38129", "l": "1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74721", "l": "7-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine => myricetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57294", "l": "a guanosine in RNA + glycolate + H(+) => an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622390", "l": "Activation of TRPC channels by Netrin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13155", "l": "2-hydroxy-3-oxosuccinate + 2 H(+) + NADH => (R)-glycerate + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53646", "l": "(+)-corvol ether B + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35091", "l": "anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine = 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:6.3.2.40", "l": "\"cyclopeptine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12029", "l": "H2O + L-5-carboxymethylhydantoin => H(+) + N-carbamoyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9660557", "l": "RAS:GTP binds RAL GDS proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53595", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + H2O <=> 1-tetradecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019811", "l": "cocaine binding", "d": ["Binding to cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018604", "l": "4-aminobenzoate 3,4-dioxygenase (deaminating) activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + 2 H+ + O2 + 2 e- = NH3 + 3,4-dihydroxybenzoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944214", "l": "Association of procollagen type I (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68773", "l": "(2Z,6Z)-farnesyl diphosphate => diphosphate + germacrene C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42091", "l": "all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41118", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27557", "l": "all-trans-hexaprenyl diphosphate + 2 diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13114", "l": "2-acetamidofluorene + H2O + NADP(+) => H(+) + N-hydroxy-2-acetamidofluorene + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44368", "l": "Cr(6+) + 2 NADPH + O2 = Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102747", "l": "chlorophyllide-a:geranyl-geranyl diphosphate geranyl-geranyl transferase activity", "d": ["Catalysis of the reaction: H+ + chlorophyllide a(1-) + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-) <=> geranylgeranyl-chlorophyll a + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44031", "l": "L-altrarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15995", "l": "2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+) => anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17936", "l": "a 7-hydroxyisoflavone + S-adenosyl-L-methionine <=> a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45357", "l": "H2O + N-(11Z-eicosenoyl)-sphing-4-enine => (11Z)-eicosenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209910", "l": "Iodide is taken up by thyroid epithelial cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4086083", "l": "SUMOylation of ING2 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47067", "l": "4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29083", "l": "(S)-malate + ubiquinone-8 = oxaloacetate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961636", "l": "E2F1 binds the POLA1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202604", "l": "Formation of a heteromeric BMP receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46063", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23602", "l": "2-oxohexanoate + L-glutamate => 2-oxoglutarate + L-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40661", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9728150", "l": "SLC5A2 binds gliflozins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791124", "l": "Expression of DNAJB9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191636", "l": "Phosphorylation of Cx43 by c-src (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13002", "l": "1D-myo-inositol hexakisphosphate + H2O => 1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29579", "l": "Fe(2+)(in) + H(+)(in) = Fe(2+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9015111", "l": "Factor Xa inhibitors binds Xa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.2.3", "l": "\"trimethylamine-N-oxide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13423", "l": "an N-acylneuraminate 9-phosphate + phosphate => an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37173", "l": "1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72088", "l": "2 Na(+)(out) + taurodeoxycholate(out) => 2 Na(+)(in) + taurodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69173", "l": "Joining of adjacent Okazaki fragments (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047187", "l": "deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity", "d": ["Catalysis of the reaction: deacetyl-[citrate-oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + S-acetylphosphopantetheine = [citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + pantetheine 4'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080030", "l": "methyl indole-3-acetate esterase activity", "d": ["Catalysis of the reaction: methyl indole-3-acetate + H2O = indole-3-acetate + methanol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693593", "l": "D-loop extension by DNA polymerases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174255", "l": "Degradation multiubiquitinated Cyclin A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14824", "l": "beta-L-arabinopyranose <=> L-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51487", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57016", "l": "3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227860", "l": "ITCH homolog downregulates MDA5/IPS1 signaling   (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648883", "l": "p-T-EIF2AK1:ferriheme dimer autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12840", "l": "ATP + choline <=> ADP + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833674", "l": "CDH11 forms homotypic trans dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40622", "l": "H2O + tridodecanoylglycerol <=> 2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047717", "l": "imidazoleacetate 4-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + imidazol-4-ylacetate + NADH + O2 = 5-hydroxyimidazole-4-acetate + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41750", "l": "1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725345", "l": "NPM-ALK-dependent JUNB translation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008456", "l": "CDKN1A gene expression is inhibited by RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55842", "l": "calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP => calcidiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64579", "l": "2 Fe(III)-[cytochrome b5] + NADPH <=> 2 Fe(II)-[cytochrome b5] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381644", "l": "ER calcium channels open in response to activated PKA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19819", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67422", "l": "a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+) => a glycerophospholipid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66876", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451900", "l": "IL2RB binds JAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749590", "l": "ASA- acetylates ALB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296326", "l": "HCAR1 binds LACT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694427", "l": "MIA3 binds procollagen VII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53666", "l": "H(+) + 2 H2O + pyridinestrone carboxylate => (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0004383", "l": "guanylate cyclase activity", "d": ["Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447034", "l": "CHL1 interacts with Ankyrin-G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0004344", "l": "glucose dehydrogenase activity", "d": ["Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.74", "l": "\"pyridoxal phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75188", "l": "2,5-dihydroxybenzoyl-CoA + H2O => 2,5-dihydroxybenzoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45840", "l": "(3R)-3-hydroxydecanoyl-CoA + NADP(+) = 3-oxodecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050191", "l": "phosphoglycerate kinase (GTP) activity", "d": ["Catalysis of the reaction: 3-phospho-D-glycerate + GTP = 3-phospho-D-glyceroyl phosphate + GDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51902", "l": "acetate + spermidine => H2O + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818937", "l": "MEN1 binds MLL1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52810", "l": "H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine => adenosine in U6 snRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71309", "l": "chloride(in) + L-valine(in) + 2 Na(+)(in) => chloride(out) + L-valine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5336443", "l": "LIN7, CASK and APBA1 bind (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021334", "l": "STAT1 binds HEY1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161588", "l": "Delta12-PGJ2 is dehydrated to 15d-PGJ2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449087", "l": "CD4 binds Interleukin-16 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-392749", "l": "Transport of L1 into endosomes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20437", "l": "5D-5-O-methyl-chiro-inositol + NADP(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.142", "l": "\"D-pinitol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71287", "l": "phosphocreatine + H2O => creatinine + orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034001", "l": "chondroitin-sulfate-ABC exolyase activity", "d": ["Catalysis of the exolytic cleavage of disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177934", "l": "EGFR autophosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60848", "l": "a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28615", "l": "(1Z,2S)-2-methylbutanal oxime => (2S)-2-methylbutanenitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33759", "l": "a 3-oxo-fatty acyl-CoA + H(+) + NADPH = a 3-hydroxy-fatty acyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73577", "l": "(E,E)-piperoyl-AMP + diphosphate => (E,E)-piperate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48302", "l": "glycerol + H(+) + prostaglandin F2alpha => H2O + prostaglandin F2alpha 1-glyceryl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443439", "l": "c-Src binds Raf1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67614", "l": "a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399712", "l": "Activation of Ca permeable AMPA receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9710959", "l": "p-STAT1 dimer binds KPNA1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706364", "l": "Internalization of ubiquitinated FLT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351208", "l": "Spermidine  => N-acetylated spermidine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30718", "l": "(2E)-geraniol <=> (S)-linalool", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033734", "l": "(R)-benzylsuccinyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-2-benzylsuccinyl-CoA + 2 electron-transferring flavoprotein = (E)-2-benzylidenesuccinyl-CoA + 2 reduced electron-transferring flavoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47093", "l": "(S)-2,3-dihydrodipicolinate + NADP(+) => dipicolinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48180", "l": "H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912367", "l": "MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57299", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O <=> a 2'-deoxyguanosine in DNA + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16727", "l": "a phosphatidylglycerol + phosphate => a phosphatidylglycerol phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876446", "l": "p-ULK1 phosphorylates DENND3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26199", "l": "ammeline + NH4(+) => H2O + melamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75469", "l": "ethanolamine(in) + n H(+)(out) => ethanolamine(out) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20525", "l": "ATP + ethylamine + L-glutamate = ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate", "d": []}, {"i": "EC:6.3.1.6", "l": "\"glutamate--ethylamine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.60", "l": "\"caspase-7\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20195", "l": "H(+) + mevaldate + NADPH => (R)-mevalonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44937", "l": "(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710295", "l": "IRF2 or IRF1 binds the GSDMD gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59574", "l": "4-aminobutanoate + L-histidine => H2O + L-homocarnosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71447", "l": "D-alanine(in) + Na(+)(in) = D-alanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53800", "l": "lithocholoyl-CoA + ursodeoxycholate = lithocholate + ursodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617445", "l": "HOXD1 chromatin is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.5", "l": "\"xylose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10969", "l": "a carboxylate + CoA + GTP => an acyl-CoA + GDP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69704", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphingosine + H2O => beta-D-galactose + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32404", "l": "(1R,2S,4R)-neodihydrocarveol + NAD(+) => (1R,4R)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59126", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate => (S)-2,3-diaminopropanoate + ATP + citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9757256", "l": "MCM3 binds MCM5 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198813", "l": "GSTO dimers reduce DeHA to AscH- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20433", "l": "NAD(+) + xylitol = D-xylulose + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.9", "l": "\"D-xylulose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9770141", "l": "Formation of the Spliceosomal C* complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45720", "l": "N-hexadecanoylsphing-4-enine(in) = N-hexadecanoylsphing-4-enine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40877", "l": "(2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2 => (9Z,12Z)-octadecadienoyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120226", "l": "succinyl-CoA binding", "d": ["Binding to succinyl-CoA, an omega-carboxyacyl-CoA having succinoyl as the S-acyl component."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730505", "l": "SARS-CoV-2 3a binds to UVRAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72621", "l": "Ribosomal scanning  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662599", "l": "MT1M binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55157", "l": "a quinone + glutathione + H(+) + hydrogen sulfide => a quinol + S-sulfanylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047870", "l": "discadenine synthase activity", "d": ["Catalysis of the reaction: N(6)-dimethylallyladenine + S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + discadenine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851436", "l": "CFHR dimers bind C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73649", "l": "CTP(in) + IMP(out) => CTP(out) + IMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28019", "l": "enterobactin + 3 H2O => 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944255", "l": "Association of procollagen type VII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56336", "l": "ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.76", "l": "\"ent-isokaurene C2/C3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209973", "l": "Tyrosine is diiodinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36007", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0034071", "l": "aminoglycoside phosphotransferase activity", "d": ["Catalysis of the reaction: ATP + aminoglycoside = ADP + phosphoaminoglycoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56843", "l": "5-amino-2-hydroxybenzoate + O2 <=> (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52356", "l": "3'-phosphoadenylyl sulfate + pregnenolone = adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72869", "l": "A[3'-5']pG[3'-5']pAp[3'] + H(+) => 3',3',3'-cAAG + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59906", "l": "2 H(+) + NADPH + octanoate => H2O + NADP(+) + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45324", "l": "H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60057", "l": "a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 => a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34868", "l": "ATP + CoA + thiophene-2-carboxylate => AMP + diphosphate + thiophene-2-carbonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68637", "l": "(2E)-geranyl diphosphate => diphosphate + sabinene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43920", "l": "(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14050", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690785", "l": "BAP1 binds Ub-HCFC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0015245", "l": "fatty acid transmembrane transporter activity", "d": ["Enables the transfer of fatty acids from one side of a membrane to the other. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35821", "l": "7,8-dihydromethanopterin + H(+) + NADPH => 5,6,7,8-tetrahydromethanopterin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390597", "l": "Release Of ADP From Myosin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34788", "l": "a 3beta-hydroxysteroid + NADP(+) => a 3-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57236", "l": "GMP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.49", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64214", "l": "a fatty acid + L-isoleucine => an N-(fatty acyl)-L-isoleucine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202222", "l": "Phosphorylation of PKC theta (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56074", "l": "a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP => a 2-acylphloroglucinol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21439", "l": "[translation elongation factor 2] + ATP <=> [translation elongation factor 2]-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070892", "l": "lipoteichoic acid immune receptor activity", "d": ["Combining with lipoteichoic acid and transmitting the signal to initiate an innate immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17093", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": []}, {"i": "EC:4.6.1.13", "l": "\"phosphatidylinositol diacylglycerol-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42884", "l": "(R)-mevalonate + ATP = (R)-3-phosphomevalonate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.185", "l": "\"mevalonate 3-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70975", "l": "3-sulfino-L-alanine(out) + L-aspartate(in) = 3-sulfino-L-alanine(in) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67490", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809521", "l": "BPIF binds bacteria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13952", "l": "H(+) + NADP(+) + 2 reduced [rubredoxin] <=> NADPH + 2 oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799097", "l": "ATM phosphorylates ZNF420 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51034", "l": "dichlorochromopyrrolate + H(+) + NH4(+) => 7-chloroindole-3-pyruvate imine dimer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36038", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69444", "l": "(2E,6E)-farnesyl diphosphate = alpha-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10745", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) => 3,4-dihydroxybenzoate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102523", "l": "2-chloroacrylate reductase activity", "d": ["Catalysis of the reaction: (S)-2-chloropropanoate + NADP <=> 2-chloroacrylate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62369", "l": "Fe(2+)(out) + 2 hydrogencarbonate(out) => Fe(2+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16654", "l": "D-gluconate + NADP(+) => 2-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39905", "l": "3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+) => isoxazolin-5-one + O-acetyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005297", "l": "proline:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28267", "l": "(2E,6E)-farnesyl diphosphate => (S)-beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2534096", "l": "METAP1/2 demethylates GNAT1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65507", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O <=> 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140816", "l": "NAD+-histone H2BS6 serine ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of ADP-ribose groups to the serine-6 or an equivalent residue of the N-terminal tail of histone H2B."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141423", "l": "Binding of the MCC complex to the APC/C complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395764", "l": "atREs binds to nascent CM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50444", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 = prostaglandin G3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74985", "l": "(3R)-3-isocyanylbutanoyl-[ACP] + AMP + H(+) => (3R)-3-isocyanylbutanoyl-AMP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75891", "l": "Abortive Initiation After Second Transition (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69370", "l": "17beta-hydroxyandrost-4-ene-3,11-dione + H(+) + NADH => 11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33849", "l": "(4R)-hydroxysphinganine + tetracosanoate => H2O + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004465", "l": "lipoprotein lipase activity", "d": ["Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36610", "l": "2-oxoglutarate + L-arginine + O2 <=> (2S,3S)-hydroxyarginine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376122", "l": "DSCAM/DSCAML1 homodimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42074", "l": "(4S)-4-hydroxy-2-oxoheptanedioate => (4Z)-2-oxohept-4-enedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389350", "l": "Activation of Cdc42 by pVav1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445705", "l": "Release Of ADP From Myosin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201519", "l": "ALK:PTN dimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045029", "l": "G protein-coupled UDP receptor activity", "d": ["Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19524", "l": "acetyl-CoA + phosphate <=> acetyl phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190519", "l": "Internalization of gap junction plaques (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13655", "l": "[6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose => [6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694389", "l": "nsp3 is glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37429", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16133", "l": "H2O + N(1)-acetylspermine + O2 = 3-aminopropanal + H2O2 + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59408", "l": "H2O + N-acetyl-L-aspartate = acetate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55979", "l": "glutathione + thiosulfate <=> H(+) + S-sulfanylglutathione + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805426", "l": "CARD8 binds CASP9(1-416) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44681", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74352", "l": "2 (S)-lactate(in) + prostaglandin E3(out) => 2 (S)-lactate(out) + prostaglandin E3(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40204", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805479", "l": "TP53RK phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141367", "l": "Myristoylation of tBID by NMT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63146", "l": "(15Z)-tetracosenoate + ethanolamine => H2O + N-(15Z-tetracosenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75210", "l": "Ag(+)(out) <=> Ag(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626276", "l": "HSP90 dissociates from LAMP2a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28608", "l": "(E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417843", "l": "P2Y13 binds ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23435", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67762", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46313", "l": "3-oxochol-4-en-22-oyl-CoA + acetyl-CoA => 3,22-dioxochol-4-en-24-oyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22349", "l": "4-aminoimidazole + H(+) + H2O => imidazol-4-one + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12871", "l": "(4S)-limonene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74180", "l": "a secondary alkyl amine + H2O + NADP(+) => a ketone + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16320", "l": "(S)-indan-1-ol + NAD(+) <=> H(+) + indan-1-one + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67266", "l": "(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine => (2S,4S)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39021", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40341", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944254", "l": "Association of procollagen type XXVI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1013020", "l": "Activation of GIRK/Kir3 Channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.1", "l": "\"pyruvate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47568", "l": "ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GD1b (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.461271292734189", "identifiers": [{"i": "GO:0016830", "l": "carbon-carbon lyase activity", "d": ["Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685156", "l": "ATR phosphorylates RPA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912680", "l": "Inhibition of JAK kinase activity by SOCS1/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917987", "l": "TFRC dimer binds 2xholoTF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55188", "l": "5-methyluridine(54) in tRNA + ATP + hydrogen sulfide = 5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44530", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44166", "l": "adenine + D-ribose 5-triphosphate => ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16193", "l": "an (R)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27675", "l": "ATP + dADP => ADP + dATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69876", "l": "6-deoxocastasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxycastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29777", "l": "ADP + alpha-D-ribose 1,5-bisphosphate + H(+) => alpha-D-ribose 1-phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9817575", "l": "ERO1B oxidizes P4HB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52515", "l": "a quinone + trans-4-hydroxy-L-proline <=> (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5334794", "l": "FABPs bind LCFAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33494", "l": "2-hydroxyhexacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451311", "l": "Activation of Ca-permeable Kainate receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58140", "l": "acetyl-AMP + cytidine(34) in elongator tRNA(Met) = AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016762", "l": "xyloglucan:xyloglucosyl transferase activity", "d": ["Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45899", "l": "an N-acyl-sphingoid base + CDP-ethanolamine <=> an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50919", "l": "a carboxylate + ATP + H(+) + NADPH <=> AMP + an aldehyde + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938913", "l": "RUNX1 binds ELF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9035227", "l": "TXN2 binds CysS248-MPST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47848", "l": "2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757578", "l": "ALB binds PREDN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56032", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50596", "l": "acetyl-CoA + N-terminal L-seryl-[histone H4] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2399913", "l": "atRAL binds to RBP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35896", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48385", "l": "a 2,3-saturated fatty acid + H2O2 => a 3-hydroxy fatty acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247849", "l": "WLS dissociates from retromer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222690", "l": "DlaT reactivates AhpD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61675", "l": "ATP + H(+) + L-cysteine <=> diphosphate + L-cysteinyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50972", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875817", "l": "MET phosphorylates STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20597", "l": "2 L-cysteine + NAD(+) = H(+) + L-cystine + NADH", "d": []}, {"i": "EC:1.8.1.6", "l": "\"cystine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17002", "l": "amidinoproclavaminate + H2O => proclavaminate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52285", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109858", "l": "MAP2K2 binds MAPK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001077", "l": "(1->3),(1->4)-beta-glucan binding", "d": ["Binding to (1->3),(1->4)-beta-glucan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10815", "l": "H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) <=> 2 H(+) + N-succinyl-L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035529", "l": "NADH pyrophosphatase activity", "d": ["Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33104", "l": "(2E,6E)-farnesyl diphosphate => alpha-muurolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39855", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol = a triacyl-sn-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912734", "l": "CBL:CRKL binds RAPGEF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42301", "l": "a fatty acyl-[ACP] + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72001", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + preaspterpenacid acid II => O2 + preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57537", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + a ribonucleoside 5'-triphosphate => a 5'-end NTP-ribonucleotide-RNA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13929", "l": "agmatine + H2O = putrescine + urea", "d": []}, {"i": "EC:3.5.3.11", "l": "\"agmatinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374672", "l": "Cis-heterodimerization of L1 and Axonin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111883", "l": "Hydrolysis of phosphatidylcholine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57410", "l": "3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH => (2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196857", "l": "PANK2 phosphorylates PanK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39356", "l": "(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH => (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849646", "l": "SPINK5(490-624) binds KLK5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825306", "l": "Expression of DLL3 in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730856", "l": "Autophosphorylation of PAK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46525", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57885", "l": "diphosphate + H2O + Na(+)(in) => H(+) + Na(+)(out) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210805", "l": "Removal of miRNA passenger strand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12904", "l": "D-arginine + H2O <=> D-ornithine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40562", "l": "dTDP-beta-L-evernosamine + NADPH + O2 <=> dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38089", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48330", "l": "GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E)) => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17214", "l": "UDP-N-acetyl-alpha-D-glucosamine => UDP-N-acetyl-alpha-D-mannosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429767", "l": "Passive I- efflux mediated by SMCT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35210", "l": "H2O + IDP <=> H(+) + IMP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6794347", "l": "Homer1,2,3 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34766", "l": "(S,S)-tartrate(out) + succinate(in) <=> (S,S)-tartrate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11065", "l": "beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55861", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62346", "l": "diphosphate + notoamide S => 6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0033549", "l": "MAP kinase phosphatase activity", "d": ["Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69246", "l": "5-methylsulfinylpentyl nitrile + sulfate + sulfur => (Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68233", "l": "L-cysteine(in) + Na(+)(in) => L-cysteine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46642", "l": "7alpha-hydroxy-5beta-cholestan-3-one + NADP(+) => 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354097", "l": "Activation of Talin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034542", "l": "trimethylarsine oxidase activity", "d": ["Catalysis of the reaction: trimethylarsine oxide + 2 H+ + 2 e- = trimethylarsine + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "68.086235947127733", "identifiers": [{"i": "GO:0008289", "l": "lipid binding", "d": ["Binding to a lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17104", "l": "H2O + O-acyl-(R)-carnitine <=> (R)-carnitine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2464822", "l": "RDH12 reduces atRAL to atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002401", "l": "Association of procollagen type XVIII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24204", "l": "acetyl phosphate + H(+) + sulfite = phosphate + sulfoacetaldehyde", "d": []}, {"i": "EC:2.3.3.15", "l": "\"sulfoacetaldehyde acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103023", "l": "ITPase activity", "d": ["Catalysis of the reaction: ITP + H2O = IDP + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43187", "l": "S-adenosyl-L-methionine + uridine(2843) in 25S rRNA <=> H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851979", "l": "BTNL9 binds immune cell surfaces (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49729", "l": "2 H(+) + NADPH + 2 O2 + protoviolaceinate => CO2 + 2 H2O + NADP(+) + violacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45836", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52094", "l": "(9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+) => 5-(9Z-hexadecenoyloxy)-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21196", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793949", "l": "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (a branch) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11333", "l": "ATP + RNA(n) => diphosphate + RNA(n)-3'-adenine ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46829", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322431", "l": "XIAP binds TLE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42430", "l": "(3R,5R)-clavulanate-9-aldehyde => clavaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47705", "l": "H(+) + iso-precytochalasin + NADPH + O2 => cytochalasin Z16 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33368", "l": "D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] => D-glucose 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40508", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220614", "l": "Spontaneous dimerization of ligand-responsive EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174255", "l": "Degradation multiubiquitinated Cyclin A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54156", "l": "2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810376", "l": "ING2 binds PI5P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13404", "l": "(2E,6E)-farnesol <=> (2Z,6E)-farnesol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9793485", "l": "PRKN polyubiquitinates RIPK3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190519", "l": "Internalization of gap junction plaques (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.116", "l": "\"cyanidin 3-O-rutinoside 5-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990887", "l": "2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol O-methyltransferase activity", "d": ["Catalysis of the reaction: 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol-n + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75453", "l": "(13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36382", "l": "3-dehydro-4alpha-methylzymosterol + H(+) + NADPH <=> 4alpha-methylzymosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32571", "l": "(E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate", "d": []}, {"i": "EC:4.2.3.118", "l": "\"2-methylisoborneol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14769", "l": "(S)-nicotine + A + H2O = (S)-6-hydroxynicotine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156910", "l": "Formation of eEF1B complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51670", "l": "H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone => 2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18230", "l": "glycolate + NAD(+) => glyoxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54893", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71461", "l": "L-Leu-L-Met-NH2 + substance P(1-9) => H2O + substance P", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11122", "l": "2 CO2 + NH4(+) => cyanate + 3 H(+) + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661039", "l": "Defective SLC9A6 does not exchange Na+ for H+ across the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49168", "l": "8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.331", "l": "\"bacteriochlorophyllide d C-12(1)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086410", "l": "CDK1 phosphorylates BORA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44740", "l": "27-O-demethylrifamycin SV + S-adenosyl-L-methionine = H(+) + rifamycin SV + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.315", "l": "\"27-O-demethylrifamycin SV methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71001", "l": "(S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20496", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine <=> an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621270", "l": "FOXO1,FOXO3 bind PINK1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204169", "l": "PDP dephosphorylates p-lipo-PDH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-984671", "l": "Chromokinesins form dimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693125", "l": "RHOF binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63620", "l": "ATP + dodecanoate + holo-[ACP] = AMP + diphosphate + dodecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.91", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26051", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165127", "l": "GEF binds to the inactive DRheb (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62668", "l": "deoxyherqueinone + H(+) + NADPH + O2 = H2O + herqueinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047694", "l": "barbiturase activity", "d": ["Catalysis of the reaction: barbiturate + H2O = malonate + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972962", "l": "POU5F1 (OCT4), SOX2, NANOG bind the TDGF1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52889", "l": "N-phenylhydroxylamine + NADP(+) => H(+) + NADPH + nitrosobenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48626", "l": "(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851890", "l": "MET phosphorylates SHC1-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008115", "l": "sarcosine oxidase activity", "d": ["Catalysis of the reaction: H2O + O2 + sarcosine = formaldehyde + glycine + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693250", "l": "RHOD binds effectors at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11994", "l": "H(+) + H2O2 + L-1-piperideine-6-carboxylate => L-pipecolate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42395", "l": "D-galactose + NAD(+) <=> D-galactono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51899", "l": "H2O + N(1)-acetylspermine <=> acetate + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51060", "l": "5alpha-androst-1-ene-3,17-dione + A = AH2 + androsta-1,4-diene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61156", "l": "3'-dephospho-CoA + GTP = CoA + GDP + H(+)", "d": []}, {"i": "EC:2.7.1.237", "l": "\"GTP-dependent dephospho-CoA kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674018", "l": "BRAP binds RAS:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35267", "l": "ethanol(in) = ethanol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18381", "l": "dihydroxyacetone + phosphoenolpyruvate = dihydroxyacetone phosphate + pyruvate", "d": []}, {"i": "EC:2.7.1.121", "l": "\"phosphoenolpyruvate--glycerone phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201611", "l": "Caspase-mediated cleavage of Rock-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72972", "l": "5-oxo-L-proline(out) + 2 Na(+)(out) => 5-oxo-L-proline(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2002428", "l": "Removal of fibrillar collagen N-propeptides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0052877", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and a copper protein is the acceptor."]}, {"i": "EC:1.4.9.-", "l": "\"With a copper protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56287", "l": "a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) <=> a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36114", "l": "gibberellin A1 + S-adenosyl-L-methionine <=> O-methyl gibberellin A1 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40181", "l": "(2E)-decenoyl-CoA + H2O2 => decanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21756", "l": "deacetylisoipecoside + H2O = dopamine + secologanin", "d": []}, {"i": "EC:4.3.3.3", "l": "\"deacetylisoipecoside synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009817", "l": "Acitretin binds to RAR:RXR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13766", "l": "bromochloromethane + H2O => bromide + chloride + formaldehyde + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867047", "l": "PTPN3 dephosphorylates EPS15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73806", "l": "AIR + CO2 => CAIR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35779", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = mutildienyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75778", "l": "(6Z,9Z,12Z)-octadecatrienoate + H2O <=> (10S)-hydroxy-(6Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12796", "l": "1D-myo-inositol hexakisphosphate + ATP <=> 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805792", "l": "p-S291-PHF20 translocates to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984606", "l": "Kinesin-5 is a homotetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68442", "l": "(3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenal => beta-cryptoxanthin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62838", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71727", "l": "citrate(out) + fumarate(in) = citrate(in) + fumarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189439", "l": "ALAD condenses 2 dALAs to form PBG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54698", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate => 4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16217", "l": "H2O + L-arabinono-1,4-lactone = H(+) + L-arabinonate", "d": []}, {"i": "EC:3.1.1.15", "l": "\"L-arabinonolactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73449", "l": "acetyl-CoA(out) + AMP(in) => acetyl-CoA(in) + AMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63287", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42351", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32657", "l": "a coniferyl ester + NADPH => a carboxylate + eugenol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27485", "l": "allantoate + 2 H(+) + H2O = (S)-2-ureidoglycine + CO2 + NH4(+)", "d": []}, {"i": "EC:3.5.3.9", "l": "\"allantoate deiminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814374", "l": "Kazrin binds periplakin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031802", "l": "type 5 metabotropic glutamate receptor binding", "d": ["Binding to a type 5 metabotropic glutamate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36486", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA <=> (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351208", "l": "Spermidine  => N-acetylated spermidine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045302", "l": "choloylglycine hydrolase activity", "d": ["Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090613", "l": "5'-deoxyadenosine deaminase activity", "d": ["Catalysis of the reaction: 5'deoxyadenosine + H2O = 5'deoxyinosine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15735", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2 => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467811", "l": "Separation of sister chromatids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.21", "l": "\"astacin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652137", "l": "Damaged dsDNA becomes damaged DNA template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39878", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32476", "l": "glycine + 3 S-adenosyl-L-methionine => glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17868", "l": "5,6,7,8-tetrahydropteridine + NADP(+) <=> 6,7-dihydropteridine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20634", "l": "a (3R)-hydroxyacyl-[ACP] + L-ornithine => a lyso-ornithine lipid + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57997", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose => (20S)-ginsenoside Rh2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32461", "l": "H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + uroporphyrinogen III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13853", "l": "4-methylene-L-glutamate + ATP + NH4(+) = 4-methylene-L-glutamine + AMP + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.1.7", "l": "\"4-methyleneglutamate--ammonia ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71635", "l": "phosphate(in) + 2 thiosulfate(out) = phosphate(out) + 2 thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002401", "l": "Association of procollagen type XVIII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791092", "l": "Expression of DCTN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51095", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616243", "l": "CEBPA gene transcription is enhanced by RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, MYB, LEF1, and CEBPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.104", "l": "\"enoyl-[acyl-carrier-protein] reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16715", "l": "glutathione + H(+) + succinate => H2O + S-succinylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46764", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.43", "l": "\"palmitoyl-[glycerolipid] 3-(E)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23167", "l": "a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose <=> a flavonol 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40025", "l": "diphosphate + syn-copalol => 9alpha-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.713784635685485", "identifiers": [{"i": "GO:0042054", "l": "histone methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047265", "l": "poly(glycerol-phosphate) alpha-glucosyltransferase activity", "d": ["Catalysis of the reaction: poly(glycerol phosphate) + UDP-D-glucose = alpha-D-glucosylpoly(glycerol phosphate) + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48526", "l": "ganglioside GQ1c + N-acetylneuraminate => ganglioside GP1c + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44924", "l": "2-oxoadipate + acetyl-CoA + H2O = (R)-dihomocitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37675", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72881", "l": "NH4(+) + phosphonoacetaldehyde => (1R)-(2-amino-1-hydroxyethyl)phosphonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9670114", "l": "Histone H3.3 deposition at telomere (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935766", "l": "miR-378 binds RUNX1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64124", "l": "H2O + N-hexadecanoyl-L-phenylalanine = hexadecanoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806610", "l": "Keratin filament formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73755", "l": "2 H(+)(out) + histamine(in) = 2 H(+)(in) + histamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237119", "l": "Acireductone is oxidized to MOB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033899", "l": "ribonuclease U2 activity", "d": ["Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Ap or Gp with 2',3'-cyclic phosphate intermediates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0050544", "l": "arachidonic acid binding", "d": ["Binding to arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.63", "l": "\"oryzin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004833", "l": "tryptophan 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19707", "l": "H(+) + hexadecanoyl-CoA + NADH => CoA + hexadecanal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69044", "l": "2-nitrobutanedioate = fumarate + H(+) + nitrite", "d": []}, {"i": "EC:4.3.99.5", "l": "\"nitrosuccinate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047246", "l": "luteolin-7-O-glucuronide 7-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: luteolin 7-O-beta-D-glucosiduronate + UDP-alpha-D-glucuronate = H+ + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19330", "l": "nuatigenin + UDP-alpha-D-glucose => H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16332", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45999", "l": "a D-alpha-amino acid + a quinone + H2O <=> a 2-oxocarboxylate + a quinol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71571", "l": "5-O-(L-seryl)-dTMP in DNA + H(+) = 5-aminoethoxy-methyl-dUMP in DNA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382054", "l": "PDGF binds to extracellular matrix proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033463", "l": "GGA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GGA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028328", "l": "SHC1 bound to activated NTRK2 recruits GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730843", "l": "Phosphorylation of LAT by p-SYK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6813749", "l": "ALDH1A1 oxidises GA to DGA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37294", "l": "H2O + L-alanyl-L-leucine <=> L-alanine + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55058", "l": "a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173631", "l": "Activation of C1s (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913360", "l": "GM-CSF receptor alpha subunit binds GM-CSF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18184", "l": "acetyl-CoA + glyoxylate + H2O <=> (S)-malate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47164", "l": "4alpha-carboxyzymosterol + NAD(+) = CO2 + NADH + zymosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879594", "l": "SLCO4C1 mediates the transport of digoxin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60883", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480470", "l": "Expression of ZIC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68900", "l": "4-methoxybenzoate + ATP + H(+) + NADPH = 4-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56484", "l": "3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] = gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43412", "l": "a D-galactosylceramide + H2O = an N-acyl-sphingoid base + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390674", "l": "ADRB1 bind ADR,NAd (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296233", "l": "T2Rs bind bitter-tasting compounds (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672969", "l": "Phosphorylation of RAF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12650", "l": "L-rhamnofuranose + NAD(+) => H(+) + L-rhamnono-1,4-lactone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.-.-", "l": "\"Other enzymes using O2 as oxidant\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31945", "l": "(25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62047", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O <=> (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5252001", "l": "ATP1B4 binds SNW1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47868", "l": "di-(9Z)-octadecenoylglycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29005", "l": "H(+)(in) + L-homoserine(out) => H(+)(out) + L-homoserine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0008126", "l": "acetylesterase activity", "d": ["Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202443", "l": "Oligomerization of CARMA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008801", "l": "beta-phosphoglucomutase activity", "d": ["Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0003995", "l": "acyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: acyl-CoA + oxidized [electron-transfer flavoprotein]= 2,3-dehydroacyl-CoA + reduced [electron-transfer flavoprotein] + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74258", "l": "XDH oxidizes xanthine to form urate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690493", "l": "RHOB binds effectors on endosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16061", "l": "H2O + sn-glycerol 3-phosphocholine = choline + H(+) + sn-glycerol 3-phosphate", "d": []}, {"i": "EC:3.1.4.2", "l": "\"glycerophosphocholine phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.6", "l": "\"ABC-type lipid A-core oligosaccharide transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54401", "l": "1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18487", "l": "acetate + D-glucose + H(+) => 6-acetyl-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030116", "l": "glial cell-derived neurotrophic factor receptor binding", "d": ["A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30511", "l": "2-demethylmenaquinone-8 + H(+) + NADPH = 2-demethylmenaquinol-8 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167134", "l": "Newly formed phosphodiester bond stabilized and PPi released (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694563", "l": "ABHD10 hydrolyses MPAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50450", "l": "A + H2O + prostaglandin H3 => AH2 + prostaglandin G3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102293", "l": "pheophytinase b activity", "d": ["Catalysis of the reaction: pheophytin b + H2O <=> H+ + pheophorbide b + phytol."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015054", "l": "gastrin receptor activity", "d": ["Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012650", "l": "JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30266", "l": "H2O2 + 2 L-ascorbate <=> 2 H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53407", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30312", "l": "7-methylxanthine + H(+) + NADH + O2 => formaldehyde + H2O + NAD(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22454", "l": "n H(+) + (n+1) phosphate => [phosphate](n+1) + n H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707856", "l": "PGRMC2:Hemes dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54374", "l": "(+)-(2S,3R,9R)-pristinol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42057", "l": "13-cis-retinol + NAD(+) => 13-cis-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731931", "l": "EDNRA binds selective ERAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60269", "l": "N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50893", "l": "a menaquinone + 2 H(+) + hydrogen sulfide + sulfite => a menaquinol + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39534", "l": "3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047150", "l": "betaine-homocysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: L-homocysteine + betaine = N,N-dimethylglycine + L-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687081", "l": "MAPK6 is ubiquitinated at the N-terminal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51533", "l": "H(+) + NADPH + O2 + urate => 5-hydroxyisourate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-901047", "l": "Binding of ERp57 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20378", "l": "androsterone + NADP(+) => 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19692", "l": "L-rhamnulose 1-phosphate <=> (S)-lactaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41644", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA = 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.43", "l": "\"2-hydroxy-7-methoxy-5-methyl-1-naphthoate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29985", "l": "cytidine(out) + H(+)(out) => cytidine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0070180", "l": "large ribosomal subunit rRNA binding", "d": ["Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209371", "l": "LGS binds to ARM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205306", "l": "Interaction of SHP1 and KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74308", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + NAD(+) => 12alpha-hydroxy-3-oxochola-4-en-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009558", "l": "IL34 dimer binds SDC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10854", "l": "diphosphate + sophoraflavanone G => dimethylallyl diphosphate + leachianone G", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848596", "l": "PTK6 binds PXN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632667", "l": "SMO dimer binds ARRB and KIF3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043774", "l": "coenzyme F420-2 alpha-glutamyl ligase activity", "d": ["Catalysis of the reaction: coenzyme F420-2 + L-glutamate + GTP = coenzyme F420-3 + GDP + orthophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19827", "l": "(+)-aristolochene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199518", "l": "C3d-complexed antigen binds to complement receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23749", "l": "ATP + GTP => diphosphate + pppGp(2'-5')A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803719", "l": "TP53 binds ZNF385A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30482", "l": "L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38776", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.157", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11492", "l": "H(+) + O-phospho-L-threonine = (R)-1-aminopropan-2-yl phosphate + CO2", "d": []}, {"i": "EC:4.1.1.81", "l": "\"threonine-phosphate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70012", "l": "2-aminobenzoyl-AMP + CoA => AMP + anthraniloyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31264", "l": "but-3-ynal + H(+) + pyrroloquinoline quinol => but-3-yn-1-ol + pyrroloquinoline quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191656", "l": "Closure of gap junction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514790", "l": "Elastin degradation by MMP14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665761", "l": "FMNL3 binds RHOC:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53544", "l": "chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14602", "l": "L-lysine + O2 => 5-aminopentanamide + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52818", "l": "an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "59.9620050747466", "identifiers": [{"i": "GO:0098772", "l": "molecular function regulator activity", "d": ["A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59543", "l": "(2R)-ethylmalonyl-CoA + H(+) <=> butanoyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429449", "l": "Syk activation leads to SLP-76 activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72409", "l": "H(+)(out) + Li(+)(in) => H(+)(in) + Li(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17622", "l": "acetyl-CoA + citramalate => (3S)-citramalyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.98.-.-", "l": "\"Enzymes using H2 as reductant\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033509", "l": "USP9X binds Ub:PEX5L (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42456", "l": "4alpha-methylzymosterol = zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14877", "l": "ATP + L-glutamate = ADP + L-glutamyl 5-phosphate", "d": []}, {"i": "EC:2.7.2.11", "l": "\"glutamate 5-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20368", "l": "phosphoethanolamine + S-adenosyl-L-methionine <=> H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13857", "l": "a dolichyl beta-D-glucosyl phosphate + H2O = a dolichyl phosphate + D-glucose + H(+)", "d": []}, {"i": "EC:3.1.4.48", "l": "\"dolichylphosphate-glucose phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50368", "l": "2-methylbutan-2-ol + H(+) + NADPH + O2 = 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)", "d": []}, {"i": "EC:1.14.19.48", "l": "\"tert-amyl alcohol desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856189", "l": "TNFSF8 binds TNFRSF8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019874", "l": "6-aminohexanoate-cyclic-dimer hydrolase activity", "d": ["Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59371", "l": "1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55222", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24630", "l": "5 H(+) + 3 NADH + nitrite => 2 H2O + 3 NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008502", "l": "melatonin receptor activity", "d": ["Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103054", "l": "gibberellin A12, 2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A15-forming)", "d": ["Catalysis of the reaction: gibberellin A12 + O2 + 2-oxoglutarate <=> gibberellin A15 + carbon dioxide + succinate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047378", "l": "acetylalkylglycerol acetylhydrolase activity", "d": ["Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycerol + H2O = 1-alkyl-sn-glycerol + acetate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59358", "l": "H(+) + lactobionate => H2O + lactobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033835", "l": "flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: UDP-L-rhamnose + a flavanone 7-O-glucoside = UDP + a flavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside]."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071885", "l": "N-terminal protein N-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser."]}, {"i": "EC:2.1.1.244", "l": "\"protein N-terminal methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24404", "l": "(3S)-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA", "d": []}, {"i": "EC:4.1.3.4", "l": "\"hydroxymethylglutaryl-CoA lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67208", "l": "H2O + melatonin = 5-methoxytryptamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26384", "l": "4-hydroxybutanoate + NADP(+) <=> H(+) + NADPH + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3159253", "l": "MMAB adenosylates cob(I)alamin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53362", "l": "H(+) + NADPH + uridine(47) in tRNA => 5,6-dihydrouridine(47) in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42429", "l": "clavaminate => (3R,5R)-clavulanate-9-aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28653", "l": "9-riburonosylhypoxanthine + H(+) + H2O => inosine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36263", "l": "hydroxyurea + O-acetyl-L-serine = acetate + H(+) + O-ureido-L-serine", "d": []}, {"i": "EC:2.6.99.3", "l": "\"O-ureido-L-serine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696822", "l": "AKR1B15 reduces EST17b to E1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59956", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate = a nitrile + sulfate + sulfur", "d": []}, {"i": "EC:4.8.1.5", "l": "\"thiohydroximate-O-sulfate sulfate/sulfur-lyase (nitrile-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419644", "l": "Transphosphorylation of pLIMK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43522", "l": "2,5-dicarboxyfuran + H(+) + H2O2 => 2-carboxy-5-(dihydroxymethyl)furan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12028", "l": "H2O + L-5-carboxymethylhydantoin = H(+) + N-carbamoyl-L-aspartate", "d": []}, {"i": "EC:3.5.2.4", "l": "\"carboxymethylhydantoinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025998", "l": "Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56774", "l": "2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O => 2 AH2 + all-trans-adonixanthin + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36127", "l": "gibberellin A34 + S-adenosyl-L-methionine = O-methyl gibberellin A34 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18384", "l": "dihydroxyacetone + phosphoenolpyruvate <=> dihydroxyacetone phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35696", "l": "(3S)-versiconol acetate + NADP(+) => (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210881", "l": "Dimerization of Tie2/Ang1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55108", "l": "3-oxononanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxynonanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350769", "l": "trans-Golgi Network Coat Activation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12856", "l": "(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose <=> dhurrin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972977", "l": "POU5F1 (OCT4), SOX2, NANOG bind the DKK1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928648", "l": "SFKs phosphorylate NGEF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156930", "l": "GTP-binding activates eEF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756661", "l": "EOMES and TBXT bind the SOX2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005129", "l": "granulocyte macrophage colony-stimulating factor receptor binding", "d": ["Binding to a granulocyte macrophage colony-stimulating factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50767", "l": "4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine <=> 4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15519", "l": "H(+) + N-sulfo-D-glucosamine + sulfate => H2O + N(2),6-disulfo-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60398", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862771", "l": "PLA2G2A binds bacterial phospholipids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176956", "l": "Formation of GINS complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28315", "l": "baicalein + UDP-alpha-D-glucuronate => baicalin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247840", "l": "WLS binds WNT ligands in the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192627", "l": "Viral mRNA Export (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351871", "l": "Caspase-mediated cleavage of Z0-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22378", "l": "pseudouridine(38/39/40) in tRNA => uridine(38/39/40) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69920", "l": "inosine(out) + 2 Na(+)(out) => inosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43534", "l": "a ribonucleoside 5'-phosphate + phosphate => a ribonucleoside 3',5'-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.20.4", "l": "\"anthocyanidin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26489", "l": "H(+) + O-phospho-L-serine + sulfite <=> L-cysteate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72717", "l": "(R)-N(6)-dihydrolipoyl-5'-AMP + diphosphate => (R)-dihydrolipoate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701147", "l": "TRPV1 binds TRPV1 blockers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034929", "l": "1-hydroxypyrene 7,8-monooxygenase activity", "d": ["Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-7,8-oxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26416", "l": "a primary amine + an aldehyde + H2O2 => a secondary aliphatic amine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59019", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) <=> CO2 + cycloeucalenone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54512", "l": "peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate", "d": []}, {"i": "EC:4.2.3.189", "l": "\"9,13-epoxylabda-14-ene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59147", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28850", "l": "Li(+)(in) + melibiose(in) <=> Li(+)(out) + melibiose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853444", "l": "AURKA phosphorylates PHLDA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052691", "l": "UDP-arabinopyranose mutase activity", "d": ["Catalysis of the reaction: UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26289", "l": "2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine = 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate", "d": []}, {"i": "EC:6.3.5.11", "l": "\"cobyrinate a,c-diamide synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202248", "l": "Phosphorylation of PLC-gamma1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25510", "l": "(1S,5S)-sabinene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729870", "l": "KCNJ2 (KIR2.1) transports K+ from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45898", "l": "an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+) => an N-acyl-sphingoid base + CDP-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28352", "l": "UDP-beta-L-arabinopyranose => UDP-beta-L-arabinofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32241", "l": "all-trans-beta-carotene => gamma-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41698", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate => 1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12107", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP <=> 7,8-dihydrofolate + dTMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33263", "l": "L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.40", "l": "\"phenylalanine N-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47597", "l": "an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74065", "l": "2-aminoisobutanoate(in) + L-alanine(out) => 2-aminoisobutanoate(out) + L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0019111", "l": "phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004919", "l": "interleukin-9 receptor activity", "d": ["Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004408", "l": "holocytochrome-c synthase activity", "d": ["Catalysis of the reaction: holocytochrome c = apocytochrome c + heme."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015244", "l": "fluconazole transmembrane transporter activity", "d": ["Enables the transfer of fluconazole from one side of a membrane to the other. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46584", "l": "1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase] = 1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685597", "l": "RTC binds SARS-CoV-1 genomic RNA complement (minus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36975", "l": "AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046409", "l": "p-coumarate 3-hydroxylase activity", "d": ["Catalysis of the reaction: shikimate or quinate ester of p-coumaric acid + NADPH + H+ + O2 = caffeic acid conjugate (caffeoyl shikimic acid or chlorogenic acid) + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912368", "l": "MIR302A microRNA binds 3'UTR of NOTCH4 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33625", "l": "AMP + diphosphate + dodecanoyl-CoA => ATP + CoA + dodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23842", "l": "(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+) => 3-(2,3-dihydroxyphenyl)propanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53249", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 7-oxocholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043830", "l": "thiol-driven fumarate reductase activity", "d": ["Catalysis of the reaction: fumarate + coenzyme M + coenzyme B = succinate + coenzyme M + coenzyme B + heterodisulfide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19944", "l": "norcoclaurine + S-adenosyl-L-methionine <=> coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31694", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60809", "l": "gibberellin A19 + H(+) + O2 => CO2 + gibberellin A20 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705145", "l": "TBK1, IKBKE form homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13216", "l": "H2O + NADP(+) + succinate semialdehyde <=> 2 H(+) + NADPH + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13578", "l": "a wax ester + H2O => a long chain fatty alcohol + a long-chain fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32771", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate = 2,6-dioxo-6-phenylhexa-3-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59846", "l": "(R)-isodihydrodehydrodiconiferyl alcohol + NADP(+) => (+)-dehydrodiconiferyl alcohol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58593", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193767", "l": "Influx of 24-hydroxycholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47125", "l": "glycine + hexacosanoate => H2O + N-hexacosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12031", "l": "H2O + L-5-carboxymethylhydantoin <=> H(+) + N-carbamoyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20154", "l": "ATP + L-arabinose => ADP + beta-L-arabinose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070012", "l": "oligopeptidase activity", "d": ["Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.118", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008734", "l": "L-aspartate oxidase activity", "d": ["Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375384", "l": "Bombesin-like receptors bind bombesin homologues (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43954", "l": "H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate => 3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42072", "l": "(4Z)-2-oxohept-4-enedioate + H2O = (4S)-4-hydroxy-2-oxoheptanedioate", "d": []}, {"i": "EC:4.2.1.163", "l": "\"2-oxo-hept-4-ene-1,7-dioate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450533", "l": "PKCdelta phosphorylates HuR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005136", "l": "interleukin-4 receptor binding", "d": ["Binding to an interleukin-4 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35360", "l": "3-hydroxyisoheptadecanoyl-CoA => (2E)-15-methylhexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446391", "l": "Formation of the PINCH-ILK-parvin complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61676", "l": "holo-[peptidyl-carrier protein] + L-cysteinyl-5'-AMP = AMP + H(+) + L-cysteinyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42015", "l": "cortisol + NAD(+) <=> 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509827", "l": "ITPA hydrolyses ITP to IMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13454", "l": "3'-phosphoadenylyl sulfate + quercetin => adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.863640214551324", "identifiers": [{"i": "GO:0016730", "l": "oxidoreductase activity, acting on iron-sulfur proteins as donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}, {"i": "EC:1.18.-.-", "l": "\"Acting on iron-sulfur proteins as donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035281", "l": "NR1H3 gene transcription regulated by NR1H2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033161", "l": "mitogen-activated protein kinase kinase kinase kinase binding", "d": ["Binding to a mitogen-activated protein kinase kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74004", "l": "A + peniprequinolone => AH2 + yaequinolone E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.121", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14541", "l": "choloyl-CoA + H2O = cholate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15909", "l": "2-oxoglutarate + O2 + taurine = aminoacetaldehyde + CO2 + H(+) + succinate + sulfite", "d": []}, {"i": "EC:1.14.11.17", "l": "\"taurine dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033232", "l": "ABC-type D-methionine transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out/in) = ADP + phosphate + D-methionine(in/out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14684", "l": "2 2-aminophenol + A + O2 <=> 2-aminophenoxazin-3-one + AH2 + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001179", "l": "RNA polymerase I general transcription initiation factor binding", "d": ["Binding to an RNA polymerase I transcription factor, a protein required to initiate or regulate transcription by RNA polymerase I."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50106", "l": "CoA + H(+) + N-tetradecanoyl-taurine => taurine + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466367", "l": "NRF1, PPRC1:HCFC1:NRF2 bind the TFB2M promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9619355", "l": "CaMKK autophosphorylates in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757441", "l": "ASA- (GI) translocates from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25653", "l": "(2S)-2-amino-3-oxobutanoate + H(+) = aminoacetone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6790038", "l": "Expression of HSP90B1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975040", "l": "KRAB-ZNF / KAP Interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47881", "l": "dioctanoylglycerol + H2O => H(+) + octanoate + octanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41709", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28001", "l": "H2O + thiamine diphosphate <=> H(+) + phosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205262", "l": "Direct recruitment of PI3K to p-KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72678", "l": "3',5'-cyclic CMP + H2O <=> CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102082", "l": "demethylrebeccamycin--D-glucose O-methyltransferase activity", "d": ["Catalysis of the reaction: 4'-demethylrebeccamycin + S-adenosyl-L-methionine <=> H+ + rebeccamycin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811454", "l": "MAPKs phosphorylate PP2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1222491", "l": "Lactoferrin scavenges iron ions (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193668", "l": "p75NTR and RHOA-GDI interact (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28414", "l": "gamma-L-glutamylputrescine + H2O + O2 = 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649655", "l": "NEIL1 recognizes and binds DHU-dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48584", "l": "2 H2O + 2 leukotriene A4 + O2 = 2 lipoxin A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20252", "l": "L-alanine <=> D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44738", "l": "3-hydroxy-2,4-dioxopentyl phosphate + CoA => acetyl-CoA + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52099", "l": "9-octadecanoyloxy-octadecanoate + H2O <=> 9-hydroxy-octadecanoate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174157", "l": "Degradation of multiubiquitinated Cyclin B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189069", "l": "sucrose + H2O => glucose + fructose (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008179", "l": "adenylate cyclase binding", "d": ["Binding to an adenylate cyclase."]}, {"i": "REACT:R-HSA-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62368", "l": "Fe(2+)(out) + 2 hydrogencarbonate(out) = Fe(2+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159773", "l": "Furin cleaves pro-protein S to protein S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168313", "l": "Virion-associated M2 protein mediated ion infusion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23440", "l": "4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride + H(+)", "d": []}, {"i": "EC:3.8.1.6", "l": "\"4-chlorobenzoate dehalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47922", "l": "ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate => ganglioside GM2 (d18:1(4E)/18:0) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50574", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018747", "l": "RHOQ GEFs activate RHOQ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68816", "l": "(2Z,6E)-farnesyl diphosphate = (E)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-179410", "l": "Association of Nek2A with MCC:APC/C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008692", "l": "IL37(?-218) binds SMAD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49524", "l": "2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 = a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate", "d": []}, {"i": "EC:1.14.11.51", "l": "\"DNA N(6)-methyladenine demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617452", "l": "Retinoic acid activates HOXB1 chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13218", "l": "H2O + NAD(+) + succinate semialdehyde => 2 H(+) + NADH + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607753", "l": "CARD9 oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912352", "l": "Galactosylation of Pre-NOTCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40625", "l": "2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate => H2O + tritetradecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50787", "l": "dodecanal + NADP(+) <=> (2E)-dodecenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2272753", "l": "Interaction of DAP12 and KIR2DS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603784", "l": "PEX19:class I PMP binds PEX3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59355", "l": "beta-lactose + O2 <=> H2O2 + lactobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10637", "l": "D-mannonate + NADP(+) => D-mannuronate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39380", "l": "(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH => (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56004", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": []}, {"i": "EC:3.2.1.209", "l": "\"endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507937", "l": "STAT5 dimers translocate to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44147", "l": "acetyl-CoA + L-methionine <=> CoA + H(+) + N(alpha)-acetyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420883", "l": "Opsins act as GEFs for G alpha-t (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14179", "l": "(R)-prunasin + D-glucose => (R)-amygdalin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16439", "l": "a halide anion + an S-substituted glutathione + H(+) => glutathione + RX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64201", "l": "an N-(fatty acyl)-L-leucine + H2O => a fatty acid + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52055", "l": "9-hexadecanoyloxy-octadecanoate + H2O <=> 9-hydroxy-octadecanoate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1369052", "l": "ABCAs mediate lipid influx (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047354", "l": "sphingosine cholinephosphotransferase activity", "d": ["Catalysis of the reaction: CDP-choline + sphingosine = CMP + H+ + sphingosyl-phosphocholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687384", "l": "SARS-CoV-1 gRNA complement (minus strand):RTC binds RTC inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37719", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909726", "l": "Phosphorylation of STAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1461995", "l": "pro-defensin alpha 5 is stored in Paneth cell granules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72037", "l": "ATP(in) + 2 H(+)(in) + phosphate(out) => ATP(out) + 2 H(+)(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863471", "l": "LDLR is bound by DAB2 and ARH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61721", "l": "a D-guloside + NAD(+) => a 3-dehydro-D-guloside + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39769", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29113", "l": "NADP(+) + ubiquinol-8 => H(+) + NADPH + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22700", "l": "gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase] = gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010872", "l": "SLIT2 binds Dystroglycan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134946", "l": "DDX41 ubiquitination by TRIM21 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032866", "l": "D-xylose:NADP reductase activity", "d": ["Catalysis of the reaction: D-xylitol + NADP+ = D-xylose + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47792", "l": "cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57230", "l": "N(2)-(1-hydroxy-2-oxoethyl)-GDP => GDP + glyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75072", "l": "chloride(out) + Cs(+)(in) + 2 hydrogencarbonate(in) => chloride(in) + Cs(+)(out) + 2 hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67180", "l": "ATP + glycine + L-glutamyl-[protein] = ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57367", "l": "H2O + NADH <=> (6S)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9652264", "l": "ERBB2 binds TKIs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72034", "l": "(E)-sinapyl alcohol + O2 <=> (E)-sinapaldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69393", "l": "an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240777", "l": "E2F1/2/3:DP1/2 binds EZH2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56506", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170149", "l": "Translocation of active Cdc25C to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61155", "l": "(E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12009", "l": "[G-protein-coupled receptor] + ATP => [G-protein-coupled receptor]-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784598", "l": "NPPA(124-151) binds NPR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014294", "l": "RAC2 binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2152276", "l": "Secretion of transmembrane collagens (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033896", "l": "ribonuclease IX activity", "d": ["Catalysis of the endonucleolytic cleavage of poly(U) or poly(C) to fragments terminated by 3'-hydroxy and 5'-phosphate groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32003", "l": "(+)-copalyl diphosphate = diphosphate + isopimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008684", "l": "TBK1 phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67256", "l": "H2O + NAD(+) + propanal = 2 H(+) + NADH + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640167", "l": "RRAGA,B exchanges GDP for GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902417", "l": "(+)-abscisic acid D-glucopyranosyl ester transmembrane transporter activity", "d": ["Enables the transfer of (+)-abscisic acid D-glucopyranosyl ester from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14856", "l": "4-chlorobenzoyl-CoA + H2O <=> 4-hydroxybenzoyl-CoA + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112125", "l": "Oxidative dealkylation of 1-EtA damaged DNA by ABH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37468", "l": "1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) => 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050058", "l": "linoleate isomerase activity", "d": ["Catalysis of the reaction: linoleate = 9-cis,11-trans-octadecadienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187261", "l": "COLEC12 (SCARA4) binds ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15029", "l": "D-mannitol + NAD(+) = D-mannose + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.255", "l": "\"mannitol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244428", "l": "botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50193", "l": "L-seryl-[protein] + UDP-alpha-D-xylose => 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210285", "l": "Trans-homophilic interaction of PECAM-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53230", "l": "16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51167", "l": "cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33160", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654511", "l": "FGFRL1 dimer binds FGFs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047385", "l": "[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity", "d": ["Catalysis of the reaction: H2O + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate = phosphate + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70352", "l": "beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O => beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983144", "l": "Transport of Antigen peptide in to ER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36856", "l": "an N-acetyl-L-cysteine-S-conjugate + H2O => acetate + an S-substituted L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13150", "l": "A + H(+) + NADPH => AH2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72103", "l": "Formation of pre-mRNPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11068", "l": "(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose", "d": []}, {"i": "EC:3.2.1.107", "l": "\"protein-glucosylgalactosylhydroxylysine glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74306", "l": "12alpha-hydroxy-3-oxochola-4-en-24-oate + NAD(+) <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390674", "l": "ADRB1 bind ADR,NAd (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62538", "l": "dihydrodigoxigenin + 2 Fe(III)-[cytochrome c] => digoxigenin + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21337", "l": "NAD(+) + pyridoxal => 4-pyridoxolactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58483", "l": "a cytidine in mRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63467", "l": "(2E,6E,10E)-geranylgeraniol + UTP <=> (2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51684", "l": "(2E,6E)-farnesyl phosphate + CTP = (2E,6E)-farnesyl diphosphate + CDP", "d": []}, {"i": "EC:2.7.4.32", "l": "\"farnesyl phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32101", "l": "DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + TRIBOA beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610627", "l": "KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977375", "l": "CR1 binds C3bBb/C4bC2a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22170", "l": "UDP-alpha-D-galactose => UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44786", "l": "H(+) + menaquinol-10 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-10 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63860", "l": "(9Z,12Z)-octadecadienoate + O2 = (2R,9Z,12Z)-2-hydroperoxyoctadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49548", "l": "H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] = H(+) + L-arginyl-[protein] + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3878123", "l": "Initiation of SAHF formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013158", "l": "CDC42 GDIs block activation of CDC42 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617096", "l": "Defective POMGNT1 does not transfer GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45383", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37262", "l": "(2S)-2-aminobutanoate + H2O + NAD(+) <=> 2-oxobutanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653840", "l": "POLD,POLE complete replication of damaged DNA after TLS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909738", "l": "SHP1 and SHP2 bind the common beta chain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098605", "l": "selenocystathionine beta-synthase activity", "d": ["Catalysis of the reaction: L-Serine + Selenohomocysteine => L-Selenocystathionine + H2O."]}, {"i": "REACT:R-HSA-2408559", "l": "SeHCys and Ser are dehydrated into SeCysta by CBS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23444", "l": "(S)-lactate + NAD(+) = H(+) + NADH + pyruvate", "d": []}, {"i": "EC:1.1.1.27", "l": "\"L-lactate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27890", "l": "3'-UMP + H2O = phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18076", "l": "(S)-dihydroorotate + A <=> AH2 + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58540", "l": "2 L-ascorbate + N-dodecanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866321", "l": "VLDL binds APOC1 and APOC4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56614", "l": "H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] => L-cysteinyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40931", "l": "2-oxoglutarate + L-ornithine + O2 = (3S)-3-hydroxy-L-ornithine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10453", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase] => (R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69356", "l": "H(+) + hypobromite + L-tyrosyl-[protein] = 3-bromo-L-tyrosyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48617", "l": "H2O + leukotriene D4 => glycine + leukotriene E4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66810", "l": "7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A => 5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37100", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848774", "l": "PTK6 binds DOK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050207", "l": "plasmanylethanolamine desaturase activity", "d": ["Catalysis of the reaction:1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5689861", "l": "Recruitment of XPA and release of CAK  (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56591", "l": "a monosubstituted aliphatic (S)-hydroxynitrile <=> an aldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67053", "l": "AH2 + asnovolin J + O2 => A + asnovolin A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63289", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52172", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49287", "l": "8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP <=> CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416929", "l": "PTGFR binds PGF2a (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48350", "l": "a pseudouridine in RNA => a uridine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28710", "l": "Cd(2+)(in) <=> Cd(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69229", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate => an epithionitrile + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39127", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.6", "l": "\"carboxylate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18830", "l": "4-phospho-D-erythronate + NAD(+) => (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67608", "l": "H2O + N(6)-methyl-ATP = diphosphate + H(+) + N(6)-methyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357483", "l": "RAC1 binds PAK1-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800793", "l": "PIDD1 translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375148", "l": "Interaction of NCAM1 with Neurocan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2545253", "l": "Deacetylation of cohesin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21507", "l": "acetoin + aldehydo-D-ribose 5-phosphate <=> 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102635", "l": "11-deoxycorticosterone reductase activity", "d": ["Catalysis of the reaction: 11-deoxycorticosterone + NADH + H+ <=> 4-pregnen-20,21-diol-3-one + NAD."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37714", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176318", "l": "Loading of claspin onto DNA during replication origin firing (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52958", "l": "hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP => hyodeoxycholate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13468", "l": "(S)-2,3-diaminopropanoate + oxalyl-CoA <=> CoA + N(3)-oxalyl-L-2,3-diaminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13667", "l": "3',5'-cyclic GMP + diphosphate => GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873919", "l": "Phosphorylation of JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36933", "l": "(9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186773", "l": "PDGF dimer binds two receptors simultaneously (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44321", "l": "1-decanoylglycerol + H2O => decanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53344", "l": "5,6-dihydrouridine(20a) in tRNA + NADP(+) = H(+) + NADPH + uridine(20a) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14890", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate => (5Z,7E,9E,14Z,17Z)-icosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38545", "l": "(2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein] => H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74740", "l": "Binding of SHC1 to insulin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429497", "l": "SLP-76 stimulates PLC gamma 2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74258", "l": "XDH oxidizes xanthine to form urate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49903", "l": "5,10-dihydrophenazine-1,6-dicarboxylate + O2 <=> H2O2 + phenazine-1,6-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5251942", "l": "Hikeshi binds HSP70s:ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26293", "l": "(1'S,5'S)-averufin + NADPH + O2 = 1'-hydroxyversicolorone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31141", "l": "3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH => (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15818", "l": "H2O + O2 + pyridoxamine 5'-phosphate => H2O2 + NH4(+) + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140107", "l": "high-affinity potassium ion transmembrane transporter activity", "d": ["Enables the transfer of potassium ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.1", "l": "\"aldehyde oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61437", "l": "ADP + H2O => AMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265177", "l": "Exocyst complex formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951486", "l": "CD46 binds C4b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49094", "l": "H(+) + hexadecanoate + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71583", "l": "L-histidine(in) + Na(+)(in) = L-histidine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016154", "l": "pyrimidine-nucleoside phosphorylase activity", "d": ["Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202459", "l": "Phosphorylation of Bcl10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672817", "l": "Active MTORC1 binds the ULK1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112510", "l": "IL6ST is tyrosine phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71170", "l": "glycine(out) + H(+)(in) + Na(+)(out) <=> glycine(in) + H(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18209", "l": "(2E)-geranyl diphosphate = (2S,4R)-bornyl diphosphate", "d": []}, {"i": "EC:5.5.1.8", "l": "\"(+)-bornyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624800", "l": "CDK1 phosphorylates LBR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11719", "l": "a monoamide of a dicarboxylate + H2O <=> a dicarboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.146", "l": "\"(iso)eugenol O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61203", "l": "acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.70", "l": "\"oligopeptidase A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54410", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37589", "l": "6-amino-2-oxohexanoate + L-glutamate => 2-oxoglutarate + D-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848776", "l": "PTK6 phosphorylates DOK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51083", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49052", "l": "asperlicin C + H(+) + NADH + O2 = asperlicin E + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2534096", "l": "METAP1/2 demethylates GNAT1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201669", "l": "Beta-catenin translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029471", "l": "Hydrolysis of PC to PA by PLD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49467", "l": "2,6-dihydroxybenzoate + H(+) <=> CO2 + resorcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47581", "l": "ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GT2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38419", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675198", "l": "Activated MAPKs phosphorylate BRAF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007514", "l": "E2F1 binds APAF1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39389", "l": "(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3229181", "l": "CALM1:Ca2+ binds CNG channel (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981926", "l": "RAC1 and CDC42 activate PAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879942", "l": "The receptor is activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507873", "l": "Aquaporins passively transport urea out of cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605717", "l": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9733969", "l": "Bile salts dissociate from FABP6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33991", "l": "(2E,6E)-farnesyl diphosphate = alpha-copaene + diphosphate", "d": []}, {"i": "EC:4.2.3.133", "l": "\"alpha-copaene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52519", "l": "trans-4-hydroxy-L-proline + ubiquinone-10 <=> (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856951", "l": "PP2A demethylation by PPME1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39258", "l": "(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1008240", "l": "NFE2 is a heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73875", "l": "(R)-adrenaline(out) = (R)-adrenaline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16034", "l": "2-oxoglutarate + gibberellin A44 + O2 => CO2 + gibberellin A19 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.240751554780076", "identifiers": [{"i": "GO:0042287", "l": "MHC protein binding", "d": ["Binding to a major histocompatibility complex molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913446", "l": "Interleukin-5 is a homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23097", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29307", "l": "FMNH2 + methanesulfonate + O2 = FMN + formaldehyde + 2 H(+) + H2O + sulfite", "d": []}, {"i": "EC:1.14.14.34", "l": "\"methanesulfonate monooxygenase (FMNH2)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36607", "l": "2-oxoglutarate + L-arginine + O2 = (2S,3S)-hydroxyarginine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.41", "l": "\"L-arginine hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16577", "l": "ADP + ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate", "d": []}, {"i": "EC:2.7.7.53", "l": "\"ATP adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-417820", "l": "P2Y9 receptor can bind to LPA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16769", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate = (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20833", "l": "ATP + guanine(out) + H2O => ADP + guanine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120048", "l": "U6 snRNA (adenine-(43)-N(6))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + adenine(43) in U6 snRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine(43) in U6 snRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26461", "l": "ethylnitronate + FMNH2 + O2 <=> acetaldehyde + FMN + 2 H(+) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008424", "l": "glycoprotein 6-alpha-L-fucosyltransferase activity", "d": ["Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47026", "l": "[DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+) => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57601", "l": "a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60774", "l": "3 CO2 + gibberellin A9 + 2 H2O + 2 succinate => 2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010523", "l": "ROBO2 gene transcription is stimulated by HOXA2 and inhibited by LHX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944230", "l": "Association of procollagen type XVIII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33106", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-muurolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28204", "l": "2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin] => 2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432148", "l": "Fgr may phosphorylate p38 MAPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042263", "l": "neuropeptide F receptor activity", "d": ["Combining with neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Neuropeptide F is an arthropod peptide of more than 28 residues (typically 28-45) with a consensus C-terminal RxRFamide (commonly RPRFa, but also RVRFa."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613530", "l": "PRKAA2 phosphorylates PLINs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16515", "l": "acetate + CO2 + H2O => (S)-lactate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58508", "l": "(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O = (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39775", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.9", "l": "\"ferric-chelate reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797100", "l": "CCNK binds CDK13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871227", "l": "RET binds GFRA4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44712", "l": "a 1,2-diacylglycerol + H2O = a 1-acylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209536", "l": "IkB is ubiquitinated and degraded (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035615", "l": "clathrin adaptor activity", "d": ["Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62424", "l": "(E)-caffeoyl-CoA + H2O = 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15013", "l": "3alpha(S)-strictosidine + H2O = secologanin + tryptamine", "d": []}, {"i": "EC:4.3.3.2", "l": "\"strictosidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033039", "l": "salty taste receptor activity", "d": ["Combining with soluble salty compounds to initiate a change in cell activity. These receptors are responsible for the sense of salty taste."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10730", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH => GDP-6-deoxy-alpha-D-talose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14610", "l": "D-sorbitol + NADP(+) => H(+) + keto-L-sorbose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005358", "l": "high-affinity glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34856", "l": "2 H2O + iminodiacetonitrile => N-(cyanomethyl)glycine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296127", "l": "Activation of voltage gated Potassium channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75891", "l": "Abortive Initiation After Second Transition (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69579", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoadipate + H(+) <=> (R)-N6-(S8-glutaryldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3878123", "l": "Initiation of SAHF formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25352", "l": "H2O + L-cysteinyl-tRNA(Pro) => H(+) + L-cysteine + tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035185", "l": "NR1H2,3 binds the NR1H3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850777", "l": "SPINK6 binds KLK14 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30704", "l": "H(+) + salicylate => CO2 + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48378", "l": "a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+) => a neolactoside nLc4Cer + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332388", "l": "Activation of MAP3K7 in response to WNT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24567", "l": "a 3-oxo acid + succinyl-CoA <=> a 3-oxoacyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5138459", "l": "WNT5A:FZD4 is endocytosed (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42051", "l": "3-hydroxybutanoyl-CoA + NAD(+) <=> acetoacetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-167415", "l": "G-protein alpha subunit is inactivated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213246", "l": "Disassociation of CLIP from MHC II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177694", "l": "Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19600", "l": "H2O + L-arginine <=> L-citrulline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68466", "l": "2-butyloctan-1-ol + H(+) + sulfate => 2-butyloctyl sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13993", "l": "(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.22", "l": "\"(S)-3-amino-2-methylpropionate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72697", "l": "UDP-N-acetyl-alpha-D-glucosamine(out) + UMP(in) => UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12147", "l": "cyanidin 3-O-rutinoside + UDP-alpha-D-glucose <=> cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851890", "l": "MET phosphorylates SHC1-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69516", "l": "N-acetyl-D-galactosamine + O2 = H2O2 + N-acetyl-D-galactosamino-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102755", "l": "gibberellin-15(closed lactone form),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating) activity", "d": ["Catalysis of the reaction: gibberellin A15 (closed lactone form) + O2 + 2-oxoglutarate = gibberellin A37 (closed lactone form) + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042951", "l": "arbutin transmembrane transporter activity", "d": ["Enables the transfer of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685838", "l": "CX3 complex binds D-loop structures (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111962", "l": "PDE4A,C,D hydrolyse cAMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38029", "l": "(E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate => (E)-caffeate + hydrocaffeoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004455", "l": "ketol-acid reductoisomerase activity", "d": ["Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65729", "l": "2-oxoglutarate + hexyl sulfate + O2 => CO2 + H(+) + hexanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24926", "l": "L-homoserine <=> 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660503", "l": "Expression of CSRP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990889", "l": "H4K20me3 modified histone binding", "d": ["Binding to a histone H4 in which the lysine residue at position 20 has been modified by trimethylation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849463", "l": "PTK6 phosphorylates SFPQ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848939", "l": "PTK6 binds KHDRBS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59218", "l": "CO2 + skatole => (indol-3-yl)acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63559", "l": "dynorphin A-(1-13) + H2O <=> dynorphin A-(1-12) + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16904", "l": "acetyl-CoA + L-2,4-diaminobutanoate <=> (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48931", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55307", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.134", "l": "\"dTDP-6-deoxy-L-talose 4-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350769", "l": "trans-Golgi Network Coat Activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193656", "l": "p75NTR interacts with RIP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21434", "l": "H(+) + NADH + oxaloacetate => (S)-malate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0019778", "l": "Atg12 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71325", "l": "chloride(in) + L-asparagine(in) + 2 Na(+)(in) => chloride(out) + L-asparagine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64743", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine <=> 3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20512", "l": "ATP + viomycin <=> ADP + H(+) + O-phosphoviomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050160", "l": "orsellinate-depside hydrolase activity", "d": ["Catalysis of the reaction: H2O + orsellinate depside = 2 o-orsellinate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375151", "l": "Interaction of NCAM1 with collagens (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25595", "l": "5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2 => 2-oxoglutarate + H(+) + isochorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41775", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) <=> CMP + ganglioside GQ1b (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102058", "l": "jasmonoyl-leucine synthetase activity", "d": ["Catalysis of the reaction: L-leucine + ATP(4-) + a jasmonic acid <=> AMP(2-) + diphosphoric acid + a jasmonoyl-leucine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801666", "l": "PLK2 phosphorylates CENPJ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3076905", "l": "Extracellular BTD hydrolyses BCTN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9612509", "l": "SGK phosphorylates SRF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38155", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (6E,10E)-geranyllinalool + diphosphate", "d": []}, {"i": "EC:4.2.3.144", "l": "\"geranyllinalool synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5615668", "l": "AKR1C3 reduces atRAL to atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11261", "l": "H(+) + NADPH + O2 => H2O2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22105", "l": "2-oxoglutarate + nicotianamine => 3''-deamino-3''-oxonicotianamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189439", "l": "ALAD condenses 2 dALAs to form PBG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34520", "l": "N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine => [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005994", "l": "TRPC3 gene transcription is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74470", "l": "a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + H2O <=> a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17675", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => quercetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803233", "l": "Dissociation of oncogenic RAS:RAF complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4837364", "l": "Secretion of SOD3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19485", "l": "sphing-4-enine + UDP-alpha-D-galactose = beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.23", "l": "\"sphingosine beta-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030354", "l": "melanin-concentrating hormone activity", "d": ["The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50594", "l": "15-oxoprostaglandin F1alpha + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11038", "l": "a quaternary ammonium(in) + ADP + H(+) + phosphate => a quaternary ammonium(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67229", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA => (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45153", "l": "3-hydroxy-3-(methylsulfanyl)propanoyl-CoA => 3-oxopropanoyl-CoA + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41856", "l": "3-oxodecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56298", "l": "pyruvate + S-sulfanyl-L-cysteinyl-[protein] => 2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114684", "l": "Phosphorylation of Syntaxin-4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247844", "l": "WNT ligands traffic to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9620103", "l": "ALDH2 transforms GTN to NO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16540", "l": "(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O <=> (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66410", "l": "ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47631", "l": "glyoxylate + H2O + propanoyl-CoA <=> 3-methylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856951", "l": "PP2A demethylation by PPME1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102680", "l": "campest-4-en-3-one hydroxylase activity", "d": ["Catalysis of the reaction: H+ + campest-4-en-3-one + O2 + NADPH <=> (22S)-22-hydroxycampest-4-en-3-one + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47838", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP => [5-(aminomethyl)-3-furyl]methyl phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48506", "l": "D-glycero-D-manno-heptose 1-phosphate + phosphate => D-glycero-D-manno-heptose 1,7-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030752", "l": "5-hydroxyfuranocoumarin 5-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 5-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 5-methoxyfuranocoumarin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65620", "l": "hexadecanoyl-CoA + sphinga-(4E,8E)-dienine = CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14618", "l": "CoA + glutathione + NADP(+) => CoA-glutathione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163750", "l": "Dephosphorylation of phosphoPFKFB1 by PP2A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62291", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate <=> (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47490", "l": "isodeoxycholate + NADP(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59828", "l": "H2O + S-inosyl-L-homocysteine = inosine + L-homocysteine", "d": []}, {"i": "EC:3.13.1.9", "l": "\"S-inosyl-L-homocysteine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450088", "l": "GLUT1 tetramer binds 4xATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62029", "l": "H2O + stigmasteryl 3-beta-D-glucoside => D-glucose + stigmasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102500", "l": "beta-maltose 4-alpha-glucanotransferase activity", "d": ["Catalysis of the reaction: beta-D-glucose + a plant soluble heteroglycan = a plant soluble heteroglycan + maltose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949609", "l": "Formation of MIB complex containing the MICOS complex causes curvature of mitochondrial inner membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44560", "l": "4-hydroxybenzoate + all-trans-heptaprenyl diphosphate = 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51113", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38736", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35840", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA => a cardiolipin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42293", "l": "a fatty acyl-[ACP] + phosphate => an acyl phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40799", "l": "2-methylpropanoyl-CoA + H2O = 2-methylpropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265456", "l": "NPC1L1 binds ezetimibe (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050422", "l": "strictosidine beta-glucosidase activity", "d": ["Catalysis of the reaction: 3alpha(S)-strictosidine + H2O = D-glucose + strictosidine aglycone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380294", "l": "Loss of C-Nap-1 from centrosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35824", "l": "5,6,7,8-tetrahydromethanopterin + NAD(+) => 7,8-dihydromethanopterin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350598", "l": "Arginine<=>Agmatine+CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14840", "l": "glyoxylate + H2O + O2 <=> H(+) + H2O2 + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61666", "l": "(2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+) => (2E,6E,10E)-geranylgeraniol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44148", "l": "L-lysine = D-beta-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29142", "l": "2 H(+)(in) + menaquinol-8 + nitrate <=> 2 H(+)(out) + H2O + menaquinone-8 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129353", "l": "Tropoelastin associates with microfibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47783", "l": "a cytidine in 25S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797974", "l": "LRRTMs bind NRXNs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008476", "l": "protein-tyrosine sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17141", "l": "glycine + oxaloacetate = glyoxylate + L-aspartate", "d": []}, {"i": "EC:2.6.1.35", "l": "\"glycine--oxaloacetate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391372", "l": "GNRHR binds GNRH1,2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32987", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a fatty acid + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24812", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427383", "l": "CBX3 (HP1gamma) binds histone H3 dimethylated at lysine-9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682992", "l": "KDM4A,B bind H4K20Me2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008692", "l": "IL37(?-218) binds SMAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50241", "l": "[hyaluronan](n) => n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13824", "l": "2-oxoglutarate + glutarate + O2 <=> (S)-2-hydroxyglutarate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51271", "l": "norbelladine + S-adenosyl-L-methionine <=> 4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23101", "l": "ATP + dAMP => ADP + dADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30841", "l": "UDP-N-acetyl-beta-L-fucosamine => UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38670", "l": "sphing-4-enine 1-phosphate(in) <=> sphing-4-enine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033226", "l": "2-aminoethylphosphonate binding", "d": ["Binding to 2-aminoethylphosphonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373748", "l": "SEMA4D interacts with CD72 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163810", "l": "GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19288", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol <=> a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58297", "l": "25-substituted-cholesterol + beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine => 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174097", "l": "Association of Emi1 with Cdh1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33382", "l": "4-hydroxyeicosasphinganine 1-phosphate + H2O <=> (4R)-hydroxyeicosasphinganine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38039", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27879", "l": "2',3'-cyclophospho-UMP + H2O => 3'-UMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682563", "l": "nsp12 misincorporates a nucleotide in nascent RNA minus strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70173", "l": "H(+)(out) + pemetrexed(out) => H(+)(in) + pemetrexed(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-996755", "l": "ZFPM proteins bind GATA proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2106615", "l": "Removal of siRNA passenger strand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48252", "l": "ganglioside GD2 + UDP-alpha-D-galactose = ganglioside GD1b + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28516", "l": "(R)-carnitinyl-CoA + AMP + diphosphate => (R)-carnitine + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0071568", "l": "UFM1 transferase activity", "d": ["Catalysis of the transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y = Y-UFM1 + X, where both X-UFM1 and Y-UFM1 are covalent linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654167", "l": "Activated FGFR1 binds PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25270", "l": "(R)-noradrenaline + S-adenosyl-L-methionine => (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102312", "l": "4-coumaroyl 2'-hydroxylase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + 2-oxoglutarate + O2 <=> 2,4-dihydroxycinnamoyl-CoA + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31675", "l": "NADP(+) + raucaffrinoline = H(+) + NADPH + perakine", "d": []}, {"i": "EC:1.1.1.317", "l": "\"perakine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29256", "l": "Ca(2+)(in) + Na(+)(out) => Ca(2+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508282", "l": "SYK is a substrate for JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46856", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14849", "l": "H2O + N-amidino-L-aspartate = L-aspartate + urea", "d": []}, {"i": "EC:3.5.3.14", "l": "\"amidinoaspartase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10997", "l": "2-methylpropanal oxime + S-adenosyl-L-methionine => 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798373", "l": "MDM2 ubiquitinates DYRK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33721", "l": "a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664879", "l": "ATM:PEX5 binds ATM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389026", "l": "Galanin receptors can bind galanin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31739", "l": "a 4'-hydroxyisoflavone + S-adenosyl-L-methionine = a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.46", "l": "\"isoflavone 4'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047007", "l": "pregnan-21-ol dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: NAD+ + pregnan-21-ol = H+ + NADH + pregnan-21-al."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2002460", "l": "P4HB binds Collagen chains (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661745", "l": "An unknown BILR reduces BIL to D-UBGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.8", "l": "\"heparin-sulfate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111930", "l": "Adenylate cyclase produces cAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655277", "l": "Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654625", "l": "Activated FGFR3 binds SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38696", "l": "a cardiolipin(in) => a cardiolipin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9751051", "l": "GSH cleaves AZA to 6MP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390598", "l": "Myosin Binds ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004704", "l": "NF-kappaB-inducing kinase activity", "d": ["Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40728", "l": "1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid => a 1-acylglycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27868", "l": "(R)-glycerate + alpha-D-mannose 6-phosphate => (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71303", "l": "RPE dimers isomerise RU5P to XY5P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47245", "l": "(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199935", "l": "MSK1 activates CREB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11009", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45343", "l": "[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O <=> (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167292", "l": "Resumption of elongation of HIV-1 transcript after recovery from pausing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65691", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41063", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672978", "l": "RAF phosphorylates MAP2K dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17373", "l": "all-trans-antheraxanthin = all-trans-capsanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66364", "l": "(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O = 6-methyl-3,7-dioxodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52618", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+) => 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50634", "l": "a 2-(omega-methylsulfanyl)alkylmaleate + H2O => a 2-(omega-methylsulfanyl)alkylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729454", "l": "SARS-CoV-2 N protein binds STAT1, STAT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726848", "l": "SRC phosphorylates RHOU (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5617179", "l": "PRKACA phosphorylates TNNI3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11561", "l": "(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) => catechol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37782", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39608", "l": "(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH => (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26502", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose = 2 H(+) + ternatin C5 + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299318", "l": "Activation of TASK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25337", "l": "H2O + L-cysteinyl-tRNA(Cys) <=> H(+) + L-cysteine + tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693125", "l": "RHOF binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322140", "l": "Defective MTR does not transfer CH3 group from MeCbl to HCYS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696266", "l": "RND2 binds effectors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018820", "l": "cyanamide hydratase activity", "d": ["Catalysis of the reaction: urea = cyanamide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34845", "l": "7,8-dihydromonapterin + 2 H(+) + 3 phosphate => 7,8-dihydromonapterin 3'-triphosphate + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44263", "l": "2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA <=> 4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662623", "l": "MT1F binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64072", "l": "acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA = 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34637", "l": "H2O + NADP(+) + pentalenolactone D => 1-deoxy-11-oxopentalenate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43260", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59699", "l": "D-cellotetraono-1,5-lactone + H2O <=> D-cellotetraonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607737", "l": "BCL10 oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72296", "l": "malate(out) + 3 Na(+)(out) => malate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22759", "l": "a long-chain primary fatty alcohol + O2 <=> a long-chain fatty aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1912357", "l": "ITCH ubiquitinates DTX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66341", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56922", "l": "a medium-chain fatty acyl-AMP + diphosphate => a medium chain fatty acid + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72239", "l": "estrone 3-sulfate(out) + L-glutamate(in) = estrone 3-sulfate(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163798", "l": "Furin cleaves pro-protein Z to protein Z (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033950", "l": "xyloglucan-specific exo-beta-1,4-glucanase activity", "d": ["Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the exohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56314", "l": "3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate => 3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707516", "l": "FeHM dissociates from MetHb (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20802", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698021", "l": "PTPN11:p-STAT5 binds BCL2L1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199456", "l": "PTEN dephosphorylates PIP3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944220", "l": "Association of procollagen type XXIII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432010", "l": "Aquaporin-1 passively transports water into cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59551", "l": "N,N',N''-triacetylchitotriose + O2 <=> H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29818", "l": "ATP + H2O + L-proline(out) <=> ADP + H(+) + L-proline(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692738", "l": "HRH2 binds HRH2 antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21334", "l": "CoA + H(+) + N-acetyl-D-glucosamine => acetyl-CoA + D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24013", "l": "gamma-tocopherol + S-adenosyl-L-methionine => (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322434", "l": "XIAP dissociates from ub-TLE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938356", "l": "RMB14 binds RUNX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60448", "l": "an S-substituted glutathione + H2O = glycine + S-substituted gamma-glutamyl-L-cysteine", "d": []}, {"i": "EC:3.4.17.25", "l": "\"glutathione-S-conjugate glycine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980044", "l": "NOTCH1 binds JAG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948136", "l": "ULK1 Translocates to the mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43964", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392748", "l": "L1 binds to AP-2 Clathrin complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350604", "l": "Agmatine + H2O <=> putrescine + urea (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798474", "l": "S100A8:S100A9 binds Zn2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419841", "l": "Light stimulates opsin receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24414", "l": "4-formylbenzenesulfonate + H(+) + NADH => 4-(hydroxymethyl)benzenesulfonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52731", "l": "3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate <=> a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0047141", "l": "glutathione-cystine transhydrogenase activity", "d": ["Catalysis of the reaction: cystine + 2 reduced glutathione = oxidized glutathione + 2 L-cysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66102", "l": "H2O + kynurenate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75856", "l": "Abortive Initiation Before Second Transition (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20734", "l": "[protein]-disulfide + [thioredoxin]-dithiol => [protein]-dithiol + [thioredoxin]-disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10552", "l": "D-glucose + O2 = 2-dehydro-D-glucose + H2O2", "d": []}, {"i": "EC:1.1.3.10", "l": "\"pyranose oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174491", "l": "Transport of trimeric ENV precursor to Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-265177", "l": "Exocyst complex formation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112042", "l": "Opioid binds MOR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52068", "l": "9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62109", "l": "an acyl-CoA + sn-glycero-3-phosphoethanolamine => a monoacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684261", "l": "nsp4 is glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24266", "l": "D-glyceraldehyde 3-phosphate + dihydroxyacetone => D-xylulose 5-phosphate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18621", "l": "2-oxoglutarate + a (2S)-flavan-4-one + O2 = a (2R,3R)-dihydroflavonol + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.9", "l": "\"flavanone 3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27775", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5213464", "l": "RIPK1 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804379", "l": "PRMT5 binds TTC5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3159253", "l": "MMAB adenosylates cob(I)alamin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63753", "l": "kermesate + UDP-alpha-D-glucose => carminate + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53331", "l": "H2O + UDP-2,3-diacyl-alpha-D-glucosamine <=> 2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69892", "l": "Na(+)(out) + thymidine(out) => Na(+)(in) + thymidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59380", "l": "4-amino-4-deoxyprephenate + NAD(+) = 3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.121", "l": "\"4-amino-4-deoxyprephenate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086082", "l": "cell adhesive protein binding involved in AV node cell-bundle of His cell communication", "d": ["Binding to a protein or protein complex that results in the connection of an AV node cell with a bundle of His cell and contributes to the communication between the two cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265862", "l": "Association of RAD51 with BRCA2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71830", "l": "arsenate(in) + H(+)(in) <=> arsenate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64569", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one => ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15365", "l": "3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35990", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18268", "l": "6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) <=> 6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140282", "l": "carbon-nitrogen ligase activity on lipid II", "d": ["Catalysis of the reaction: L-glutamine + lipid II + ATP + H2O = L-glutamate + beta-D-GlcNAc(1->4)-Mur2Ac(oyl-L-Ala-D-isoGln-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18187", "l": "5'-dehydroadenosine + H2O2 => adenosine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43501", "l": "beta-D-glucuronate + NAD(+) => D-glucaro-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674385", "l": "p-T,Y MAPKs dimerize (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43900", "l": "dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O = beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35415", "l": "an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose = an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.295", "l": "\"anthocyanin 3-O-sambubioside 5-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48880", "l": "a quinone + CO + H2O = a quinol + CO2", "d": []}, {"i": "EC:1.2.5.3", "l": "\"aerobic carbon monoxide dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333615", "l": "80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114552", "l": "Thrombin-activated PARs activate G12/13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57561", "l": "(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72416", "l": "Li(+)(in) + Na(+)(out) => Li(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19133", "l": "2-oxoglutarate + 3,3',5-triiodo-L-thyronine = 3,5,3'-triiodothyropyruvate + L-glutamate", "d": []}, {"i": "EC:2.6.1.26", "l": "\"thyroid-hormone transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.8.2", "l": "\"4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68366", "l": "2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+) => 4-CDP-2-C-methyl-D-erythritol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382061", "l": "Extracellular processing of novel PDGFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35906", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33295", "l": "L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74711", "l": "Phosphorylation of IRS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619843", "l": "ERKs phosphorylate RSKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483089", "l": "PE is converted to PS by PTDSS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43138", "l": "4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine => guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209738", "l": "VD3 binds GC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31681", "l": "H2O2 + prosolanapyrone III => O2 + prosolanapyrone II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213244", "l": "Loading of antigenic peptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30674", "l": "H2O + N,N'-diacetylchitobiose <=> 2 N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450325", "l": "c-FOS activation by phospho ERK1/2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38927", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928578", "l": "EPH receptors autophosphorylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161293", "l": "Tropoelastin forms aggregate globules (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57791", "l": "1,3-dinitrobenzene + NADH + O2 <=> 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43840", "l": "26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12738", "l": "5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine => [PrdC protein]-L-selenocysteine/L-cysteine + D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211219", "l": "Translocation of caspase-3 to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623072", "l": "POMC gene expression is inhibited by FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71765", "l": "2-oxoglutarate(in) + citrate(out) => 2-oxoglutarate(out) + citrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23683", "l": "a ribonucleoside 5'-triphosphate + H2O <=> a ribonucleoside 5'-diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66538", "l": "25-hydroxycholest-4,6-dien-3-one + AH2 => A + cholest-4,6-dien-3-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41147", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63979", "l": "A + dihydropyriculariol <=> AH2 + pyriculariol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.235", "l": "\"lipopolysaccharide core heptose(I) kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034557", "l": "2-hydroxylaminobenzoate reductase activity", "d": ["Catalysis of the reaction: 2-hydroxylaminobenzoate + NAD(P)H = anthranilate + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33323", "l": "a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797100", "l": "CCNK binds CDK13 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804099", "l": "HMGB1 binds LTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182988", "l": "Sprouty lures CBL away from EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.8", "l": "\"endo-1,4-beta-xylanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607740", "l": "PKC-delta phosphorylates CARD9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67678", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20921", "l": "2,4-dichlorophenol + H(+) + NADPH + O2 => 3,5-dichlorocatechol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59323", "l": "D-cellobiono-1,5-lactone + H2O <=> 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47793", "l": "cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227891", "l": "TRAF3/or TRAF6 interacts with IPS-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35607", "l": "acetoin + NADP(+) = diacetyl + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.58", "l": "\"8-oxo-dGDP phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001852", "l": "complement component iC3b binding", "d": ["Binding to a iC3b product of the complement cascade."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22752", "l": "A + H2O + uracil = AH2 + barbiturate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110319", "l": "Elongation by POLH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40376", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134896", "l": "LRR FLII-interacting protein 1 binds dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10935", "l": "ATP + L-aspartate + L-citrulline <=> 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35297", "l": "AMP + H2O + W-molybdopterin cofactor => adenylyl-molybdopterin + H(+) + tungstate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362437", "l": "C-terminal Hh fragments are bound by lectins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38652", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32026", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> avermitilol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031512", "l": "Expression of APOE regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27496", "l": "S-adenosyl-L-methionine + tricetin <=> 3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21593", "l": "(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) => H(+) + L-2-aminopentanoate + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18511", "l": "2 H2O + NAD(+) => H(+) + H2O2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31078", "l": "(3S)-3-hydroxydodecanoyl-CoA <=> (2E)-dodecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68229", "l": "glycine(in) + Na(+)(in) => glycine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250217", "l": "ARL2:GTP binds ARL2BP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40164", "l": "D-glyceraldehyde + H2O + NADP(+) => (R)-glycerate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75739", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH = 10-oxooctadecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109813", "l": "GRB2-1 binds SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65578", "l": "an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP => a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227732", "l": "IPS1 interacts with TRADD, RIP1 and FADD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50912", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol = 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.46", "l": "\"teichoic acid ribitol-phosphate primase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28659", "l": "beta-lactose + H2O = beta-D-galactose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63980", "l": "4-thiouridine + ATP = 4-thiouridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21938", "l": "H(+) + N-carbamoylputrescine + phosphate => carbamoyl phosphate + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2530445", "l": "CD59 inhibits MAC formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676596", "l": "TRAF3 binds BAFFR:BAFF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0120230", "l": "recombinase activator activity", "d": ["Binds to and increases the activity of a recombinase."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045352", "l": "interleukin-1 type I receptor antagonist activity", "d": ["Blocks the binding of interleukin-1 to interleukin-1 type I receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202437", "l": "Phosphorylation of CARMA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13461", "l": "3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2 = 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74988", "l": "erythrostominone(in) => erythrostominone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12588", "l": "ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GM2 (d18:1(4E)) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.92", "l": "\"(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49358", "l": "2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161282", "l": "Elastic fibres bind associated proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58027", "l": "oleanolate + UDP-alpha-D-glucose <=> H(+) + oleanolate 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734475", "l": "PPARA binds fibrates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654399", "l": "Activated FGFR2 binds FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69068", "l": "RFC dissociates after sliding clamp formation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66682", "l": "ADP + coproporphyrinogen III(out) + H(+) + phosphate => ATP + coproporphyrinogen III(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222686", "l": "Nitric oxide diffuses into the phagosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71362", "l": "17beta-estradiol 17-sulfate(out) + 2 Na(+)(out) <=> 17beta-estradiol 17-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085020", "l": "Cytosolic Neu5Ac translocates to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.240751554780076", "identifiers": [{"i": "GO:0004029", "l": "aldehyde dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28708", "l": "Cd(2+)(in) => Cd(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174963", "l": "NAT1 acetylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34184", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose => alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662986", "l": "MT2A binds copper (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1500761", "l": "Nitrogen dioxide is reduced to NO by F420 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645535", "l": "ALPK1 phosphorylates TIFA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52792", "l": "chlorophyllide a + 2 H(+) = Mg(2+) + pheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.879406879579491", "identifiers": [{"i": "GO:0008080", "l": "N-acetyltransferase activity", "d": ["Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176956", "l": "Formation of GINS complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22562", "l": "2'-hydroxyformononetin + 2 H(+) + NADPH => (3R)-vestitone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11689", "l": "ATP + L-leucine + tRNA(Leu) => AMP + diphosphate + L-leucyl-tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953556", "l": "E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47853", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O => a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34809", "l": "camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799246", "l": "CHEK1 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209973", "l": "Tyrosine is diiodinated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021357", "l": "PRKCI phosphorylates ELF3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35888", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69278", "l": "but-3-enenitrile + sulfate + sulfur => (Z)-N-(sulfonatooxy)prop-2-enimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13325", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = 3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate", "d": []}, {"i": "EC:1.1.1.136", "l": "\"UDP-N-acetylglucosamine 6-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798139", "l": "TP53 stimulates CASP10 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58586", "l": "(-)-tabersonine + acetate + H(+) => dihydroprecondylocarpine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49481", "l": "2 H2O + L-1-piperideine-6-carboxylate + NADP(+) => H(+) + L-2-aminoadipate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22505", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate => adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11577", "l": "ATP + thiamine => AMP + H(+) + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174202", "l": "Degradation of multiubiquitinated Securin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654163", "l": "Activated FGFR4 binds PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21083", "l": "ATP + H2O + L-methionine <=> diphosphate + phosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38669", "l": "sphing-4-enine 1-phosphate(out) => sphing-4-enine 1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34454", "l": "dTDP-6-deoxy-beta-L-talose <=> dTDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029451", "l": "Activation of RAC1 by VAV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72764", "l": "anthocyanin A10 + malonyl-CoA => anthocyanin A11 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70114", "l": "6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5226979", "l": "ADD1:ADD2 binds DMTN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18813", "l": "(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate = (3E,5R)-5-carboxy-2-oxohept-3-enedioate", "d": []}, {"i": "EC:5.3.3.10", "l": "\"5-carboxymethyl-2-hydroxymuconate Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250220", "l": "Homodimerization of ERBB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27359", "l": "iodomethane + S-adenosyl-L-homocysteine => iodide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33465", "l": "5-dehydroepisterol + 2 H2O + NADP(+) => episterol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.87", "l": "\"capsular-polysaccharide endo-1,3-alpha-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32351", "l": "3 S-adenosyl-L-methionine + tricetin = 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.169", "l": "\"tricetin 3',4',5'-O-trimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64145", "l": "H2O + N-(9Z-octadecenoyl)-L-methionine => (9Z)-octadecenoate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454916", "l": "The ABCC family mediates organic anion transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21592", "l": "(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) = H(+) + L-2-aminopentanoate + NADH + pyruvate", "d": []}, {"i": "EC:1.5.1.28", "l": "\"opine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67746", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + phosphate => 1-O-alkyl-2-acyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65850", "l": "a steroid 1,3-dione + AH2 => A + a 3-oxo-Delta(1)-steroid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24778", "l": "C-13(2)-carboxypyropheophorbide a + methanol => H2O + pheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15628", "l": "Co-precorrin-6B + NAD(+) <=> Co-precorrin-6A + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42205", "l": "corticosterone + NAD(+) => 11-dehydrocorticosterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48664", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392874", "l": "Dissociation of the Prostacyclin receptor:Gs complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167019", "l": "SHC, complexed with TrkA, is tyrosine-phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013652", "l": "NOTCH3 coactivator complex binds HES1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382054", "l": "PDGF binds to extracellular matrix proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54630", "l": "2-hydroxydodecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + dodecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70871", "l": "L-glutamine(in) + L-valine(out) + Na(+)(out) = L-glutamine(out) + L-valine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050257", "l": "riboflavin phosphotransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24238", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + trimethylamine N-oxide => 2 Fe(III)-[cytochrome c] + H2O + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114264", "l": "Translocation of activated BAX to the mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55272", "l": "11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168394", "l": "STAT5 tyrosine phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29081", "l": "pyruvate + ubiquinol-8 => (R)-lactate + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404193", "l": "IGF1R phosphorylates SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.9.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034279", "l": "syn-pimara-7,15-diene synthase activity", "d": ["Catalysis of the reaction: 9-alpha-copalyl diphosphate = 9-beta-pimara-7,15-diene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "76.274502573267668", "identifiers": [{"i": "GO:0016846", "l": "carbon-sulfur lyase activity", "d": ["Catalysis of the elimination of hydrogen sulfide or substituted H2S."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362522", "l": "ALDHs oxidise atRAL to atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49972", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050429", "l": "calcium-dependent phospholipase C activity", "d": ["Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32948", "l": "a 2-acylglycerol + an acyl-CoA => a 1,2-diacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.27", "l": "\"4-aminobenzoate 1-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10965", "l": "ATP + D-xylulose => ADP + D-xylulose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36755", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose = beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.305", "l": "\"UDP-Glc:alpha-D-GlcNAc-glucosaminyl-diphosphoundecaprenol beta-1,3-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805399", "l": "TAF1 phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62698", "l": "2 cornusiin E + 2 H2O => O2 + 4 tellimagrandin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56723", "l": "2 Fe(III)-[cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19846", "l": "nocardicin E + S-adenosyl-L-methionine => H(+) + isonocardicin A + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445705", "l": "Release Of ADP From Myosin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68543", "l": "(2Z,6Z)-farnesyl diphosphate <=> (-)-alpha-cedrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157629", "l": "NOTCH2-ligand complex is cleaved to produce NEXT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15724", "l": "glycine + H2O + NAD(+) <=> glyoxylate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14708", "l": "2 CoA + NADP(+) <=> CoA-disulfide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730862", "l": "Autophosphorylation of LYN kinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029473", "l": "Branching and elongation of mother and daughter filaments (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14508", "l": "2 glutathione + thiosulfate <=> glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41201", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate => 1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19261", "l": "ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate", "d": []}, {"i": "EC:7.6.2.5", "l": "\"ABC-type heme transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34485", "l": "4-hydroxybenzalacetone + 2 CO2 + 2 CoA => 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483219", "l": "PC is exchanged with PI by PITPNB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429157", "l": "ABCC4 accumulation of dense granule contents (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190258", "l": "FGFR2c binds to FGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60245", "l": "2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] => 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64327", "l": "(11Z)-octadecenoyl-CoA + cholesterol <=> cholesteryl (11Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180603", "l": "Proteosome-mediated degradation of APOBEC3G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54452", "l": "a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.31", "l": "\"sulfoquinovose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19774", "l": "NADP(+) + sn-glycerol 3-phosphate => D-glyceraldehyde 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0004363", "l": "glutathione synthase activity", "d": ["Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210943", "l": "pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050369", "l": "[tyrosine 3-monooxygenase] kinase activity", "d": ["Catalysis of the reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0001884", "l": "pyrimidine nucleoside binding", "d": ["Binding to a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782820", "l": "USP17 deubiquitinates SUDS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15051", "l": "D-glucose + GDP + H(+) => GDP-alpha-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028598", "l": "Phosphorylation of YAP by LATS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43013", "l": "L-homocysteine => 2-aminobut-2-enoate + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34599", "l": "15-methylhexadecasphinganine + NADP(+) = 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68641", "l": "(2E)-geranyl diphosphate => diphosphate + limonene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210932", "l": "ANTXR2-bound pagA(197-794) forms oligomers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670054", "l": "Defects in F8 A2 domain accelerate dissociation of the A2 domain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57282", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA => a guanosine in RNA + glyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20186", "l": "a CMP-N-acyl-beta-neuraminate + H2O => an N-acylneuraminate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983259", "l": "Kinesins move along microtubules consuming ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41465", "l": "ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2562526", "l": "PLK1 phosphorylates OPTN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708457", "l": "HM13 cleaves HMOX1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11073", "l": "anthranilate + 3 H(+) + NADPH + O2 => catechol + CO2 + NADP(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16636", "l": "guanosine(34) in tRNA + queuine <=> guanine + queuosine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51562", "l": "(S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine => (S)-bulbocapnine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10526", "l": "CO2 + succinate semialdehyde => 2-oxoglutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9716913", "l": "ESR1 binds ESR1 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197691", "l": "WIP binds WASP,N-WASP, activating them (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804253", "l": "MDM2 ubiquitinates JMY (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30462", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol <=> (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35326", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29650", "l": "alpha-maltopentaose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltotetraose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38037", "l": "(4Z)-2-oxohept-4-enedioate => (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41553", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O => diphosphate + ophiobolin F", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190265", "l": "FGFR4 binds to FGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19639", "l": "2-oxoglutarate + H(+) + L-arginine + NADPH => D-nopaline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11189", "l": "3-cyano-L-alanine + 2 H2O => L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74368", "l": "substance P(out) => substance P(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34619", "l": "1-deoxypentalenate + 2-oxoglutarate + O2 = 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.35", "l": "\"1-deoxypentalenic acid 11beta-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062192", "l": "L-rhamnose mutarotase activity", "d": ["Catalysis of the reaction: alpha-L-rhamnose = beta-L-rhamnose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186819", "l": "SH2 domain of Src binds to the active receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32517", "l": "(3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+) => (4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29105", "l": "4 H(+)(out) + menaquinol-8 + NAD(+) => 5 H(+)(in) + menaquinone-8 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17761", "l": "an aromatic primary alcohol + NADP(+) = an aromatic aldehyde + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.91", "l": "\"aryl-alcohol dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10429", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937989", "l": "RUNX1 binds PRC1 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28110", "l": "chloride + S-adenosyl-L-methionine = 5'-chloro-5'-deoxyadenosine + L-methionine", "d": []}, {"i": "EC:2.5.1.94", "l": "\"adenosyl-chloride synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981539", "l": "C3b binds to cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1013020", "l": "Activation of GIRK/Kir3 Channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38090", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12832", "l": "(2S,3S)-3-methyl-L-aspartate <=> mesaconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44186", "l": "2-epi-5-epi-valiolone + phosphate => D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22872", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 = CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen]", "d": []}, {"i": "EC:1.14.11.7", "l": "\"procollagen-proline 3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42257", "l": "H(+) + hexanoyl-CoA + malonyl-[ACP] => 3-oxooctanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37222", "l": "A + D-valine + H2O <=> 3-methyl-2-oxobutanoate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004149", "l": "dihydrolipoyllysine-residue succinyltransferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028598", "l": "Phosphorylation of YAP by LATS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.352", "l": "\"5'-hydroxyaverantin dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28555", "l": "D-mannose 6-phosphate + H2O => D-mannose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21317", "l": "H2O + phorbol 12,13-dibutanoate => butanoate + H(+) + phorbol 13-butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952419", "l": "SMURFs ubiquitinate RUNX3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42012", "l": "cortisol + NAD(+) = 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68611", "l": "Formation of ORC(1-5) complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23545", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose => a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56261", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose => 4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23725", "l": "H2O + O2 + pyridoxal => 4-pyridoxate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61834", "l": "H(+) + sitosteryl 3-beta-D-glucoside + UDP => sitosterol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10064", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine", "d": []}, {"i": "EC:2.1.2.7", "l": "\"D-alanine 2-hydroxymethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69717", "l": "(indol-3-yl)acetyl-CoA + AMP + diphosphate => (indol-3-yl)acetate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16142", "l": "2'-deoxymugineate + NAD(+) => 3''-deamino-3''-oxonicotianamine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193684", "l": "p62 recruits an atypical PKC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112265", "l": "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22027", "l": "H2O + NAD(+) + trimethylamine <=> 2 H(+) + NADH + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30244", "l": "4 L-ascorbate + O2 => 2 H2O + 4 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615910", "l": "SUMOylation of PCNA with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69110", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-cysteine => 2-oxo-3-sulfanylpropanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58863", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614933", "l": "ACEIs bind ACE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0034604", "l": "pyruvate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202174", "l": "Activation of ZAP-70 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24044", "l": "3,4-dihydroxybenzoate + O2 = 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": []}, {"i": "EC:1.13.11.8", "l": "\"protocatechuate 4,5-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32691", "l": "(2E)-geranyl diphosphate = (E)-beta-ocimene + diphosphate", "d": []}, {"i": "EC:4.2.3.106", "l": "\"(E)-beta-ocimene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102976", "l": "versiconal reductase activity", "d": ["Catalysis of the reaction: versiconol + NADP <=> versiconal hemiacetal + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619127", "l": "CAMK4 binds KPNA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62077", "l": "D-galactose 6-phosphate + NAD(+) => 6-phospho-D-galactono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27299", "l": "2-formylbenzoate + H2O + NAD(+) => 2 H(+) + NADH + phthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62521", "l": "a cytidine in rRNA + S-adenosyl-L-methionine => an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004605", "l": "phosphatidate cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72819", "l": "L-ornithine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) = L-ornithine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42268", "l": "2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] = 4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70970", "l": "3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in) <=> 3-sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14743", "l": "4-methylene-L-glutamate + NH4(+) => 4-methylene-L-glutamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47382", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin] => (25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67207", "l": "H2O + N-acetyltryptamine <=> acetate + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44233", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55503", "l": "ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.40", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47408", "l": "(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O = (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28959", "l": "D-xylose(in) + H(+)(in) = D-xylose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48879", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O <=> L-seryl-[protein] + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74793", "l": "(R)-salsolinol(out) => (R)-salsolinol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799761", "l": "TP53 binds PPP1R13L (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018626", "l": "2-chlorobenzoate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57166", "l": "(3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5631941", "l": "SESN1,2,3 bind AMPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28747", "l": "NH4(+)(in) = NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034840", "l": "3-hydroxymenthone dehydrogenase activity", "d": ["Catalysis of the reaction: (5R)-3-hydroxymenthone + NAD+ = mentha-1,3-dione + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28826", "l": "H(+)(in) + L-galactonate(in) <=> H(+)(out) + L-galactonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34259", "l": "(+)-larreatricin + AH2 + O2 = (+)-3'-hydroxylarreatricin + A + H2O", "d": []}, {"i": "EC:1.14.99.47", "l": "\"(+)-larreatricin hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58921", "l": "(3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol => (+)-medicarpin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12824", "l": "2-deoxy-D-ribose 5-phosphate <=> acetaldehyde + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52431", "l": "12-oxo-leukotriene B4 + H(+) + NADH <=> 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11861", "l": "ATP + L-histidyl-[protein] => ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018570", "l": "p-cumate 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34174", "l": "L-aspartate 4-semialdehyde + pyruvate <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30305", "l": "germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => (+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26050", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002112", "l": "interleukin-33 receptor binding", "d": ["Binding to an interleukin-33 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30824", "l": "UDP-N-acetyl-alpha-D-glucosamine => H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70564", "l": "H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71424", "l": "3,3',5-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) => 3,3',5-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203979", "l": "Coat Assembly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41256", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2314569", "l": "GOLGA2 phosphorylated by CDK1 is unable to promote fusion of ER to Golgi transport vesicles with cis-Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621400", "l": "EGR2 and SREBF2 dimer bind SCD5 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30678", "l": "tetrahymanol <=> H2O + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72495", "l": "glutarate(in) + prostaglandin E2(out) = glutarate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24221", "l": "beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase] => (4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57497", "l": "2-methylcitrate => 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16147", "l": "CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O => CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660828", "l": "ADORA2B:Ade-Rib binds heterometric G-protein Gs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36375", "l": "ATP + carbamoyl phosphate + H2O = carbamoyl adenylate + diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005080", "l": "protein kinase C binding", "d": ["Binding to protein kinase C."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106153", "l": "phosphorylated histone binding", "d": ["Binding to a histone in which a residue has been modified by phosphorylation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52527", "l": "O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55995", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373074", "l": "Receptor CCR9  binds CCL25 ligand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57316", "l": "ATP + cytidine 5'-diphosphoramidate = ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)", "d": []}, {"i": "EC:2.7.1.224", "l": "\"cytidine diphosphoramidate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031875", "l": "type 4 proteinase activated receptor binding", "d": ["Binding to a type 4 proteinase activated receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088281", "l": "Endorepellin binds KDR (VEGFR2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445069", "l": "L1-EGFR trans-heterodimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59065", "l": "demethylluteothin + S-adenosyl-L-methionine => luteothin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047254", "l": "2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one + UDP-D-glucose = 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42652", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.314", "l": "\"diphthine methyl ester synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052840", "l": "inositol diphosphate tetrakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: diphospho-1D-myo-inositol tetrakisphosphate + H2O = 1D-myo-inositol pentakisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53035", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20254", "l": "(2R,3S)-2,3-dimethylmalate => dimethylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44449", "l": "an acyl-CoA + H(+) + malonyl-[ACP] => a 3-oxoacyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686430", "l": "MUS81 binds EME1, EME2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018580", "l": "nitronate monooxygenase activity", "d": ["Catalysis of the reaction: ethylnitronate + O2 = acetaldehyde + nitrite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55693", "l": "an inositol-1-phosphoceramide + H2O => 1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672011", "l": "p-AMPK:AMP binds the ULK complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72539", "l": "3,4-dihydroxybenzaldehyde + H2O + NADP(+) = 3,4-dihydroxybenzoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166038", "l": "GPI-bound CD14 binds LPS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23150", "l": "ADP + propanoyl phosphate => ATP + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050447", "l": "zeatin 9-aminocarboxyethyltransferase activity", "d": ["Catalysis of the reaction: O-acetyl-L-serine + zeatin = L-lupinate + acetate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52561", "l": "2-dehydro-D-erythronate => 3-dehydro-D-erythronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050636", "l": "vinorine synthase activity", "d": ["Catalysis of the reaction: 16-epivellosimine + acetyl-CoA = CoA + vinorine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032791", "l": "lead ion binding", "d": ["Binding to lead (Pb) ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322125", "l": "Defective MMAB does not transfer adenosyl group from ATP to B12s (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044669", "l": "sodium:galactoside symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ galactoside(out) = sodium(in) + galactoside(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39022", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690740", "l": "CD22 binds B-cell receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203567", "l": "palmitoylation of eNOS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65694", "l": "a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32270", "l": "4-aminobutanoate + glyoxylate <=> glycine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44710", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44587", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607023", "l": "factor IXa associates with cell membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.35", "l": "\"tissue kallikrein\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53064", "l": "2-methoxyestrone + UDP-alpha-D-glucuronate = 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65386", "l": "(N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64158", "l": "a fatty acid + L-methionine => an N-(fatty acyl)-L-methionine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59887", "l": "2-oxoglutarate + chloride + H(+) + L-lysine + O2 <=> 4-chloro-L-lysine + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23613", "l": "1,2-dihydro-alpha-santonin + NAD(+) => alpha-santonin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9623384", "l": "α1-agonists bind ADRA1A,B,D (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210947", "l": "pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854052", "l": "Formation of the SCF-FBXL7 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42642", "l": "a menaquinol + H(+) + S-adenosyl-L-homocysteine => a 2-demethylmenaquinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42803", "l": "15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) <=> all-trans-4,4'-diaponeurosporene + 3 FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47248", "l": "2 Fe(III)-[cytochrome c] + L-gulono-1,4-lactone = 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17809", "l": "Mg-protoporphyrin IX + S-adenosyl-L-methionine = Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.11", "l": "\"magnesium protoporphyrin IX methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31604", "l": "(Z)-3-ureidoacrylate + H2O => (Z)-3-aminoacrylate + carbamate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29191", "l": "L-aspartate + menaquinone-8 = iminosuccinate + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139906", "l": "Activation of BAD by calcineurin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31411", "l": "a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69144", "l": "agmatine + H2O + O2 = 4-guanidinobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61598", "l": "[DsbD protein]-disulfide + [thioredoxin]-dithiol => [DsbD protein]-dithiol + [thioredoxin]-disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11311", "l": "acetyl-CoA + ATP + hydrogencarbonate <=> ADP + H(+) + malonyl-CoA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25061", "l": "(E)-cinnamate + H(+) + NADH + O2 <=> (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851933", "l": "MET phosphorylates GAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694427", "l": "MIA3 binds procollagen VII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662613", "l": "MT3 exchanges zinc for copper (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876446", "l": "p-ULK1 phosphorylates DENND3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009978", "l": "allene oxide synthase activity", "d": ["Catalysis of the reaction: 13(S)-hydroperoxylinolenate = 12,13(S)-epoxylinolenate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69082", "l": "3,4-dihydroxyphenylacetate + 2 H(+) + NADH => 3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30453", "l": "isomultiflorenol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26429", "l": "ATP + H2O + L-glutamine + UTP <=> ADP + CTP + 2 H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15465", "l": "ATP + sphinganine = ADP + H(+) + sphinganine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66892", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41275", "l": "H2O + N-eicosanoyl-sphing-4-enine = eicosanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18231", "l": "glyoxylate + H(+) + NADH => glycolate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49832", "l": "a fatty aldehyde + H2O + NAD(+) = a fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50903", "l": "10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O <=> (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12562", "l": "H(+) + hydroquinone O-beta-D-glucopyranoside + UDP => hydroquinone + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46499", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in) <=> N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984689", "l": "Kinesin-7 is a dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66737", "l": "ATP + beta-citrylglutamate(in) + H2O => ADP + beta-citrylglutamate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71193", "l": "an L-alpha-amino acid(out) + L-kynurenine(in) => an L-alpha-amino acid(in) + L-kynurenine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47103", "l": "choloyl-CoA + taurine <=> CoA + H(+) + taurocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32866", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10237", "l": "trans-2-coumarate + UDP-alpha-D-glucose => H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56912", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) = (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022073", "l": "Procollagen triple helix formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57696", "l": "ATP + cob(I)inamide-[corrinoid adenosyltransferase] = adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71764", "l": "2-oxoglutarate(out) + citrate(in) => 2-oxoglutarate(in) + citrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709179", "l": "DPP4 binds DPP4 inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183052", "l": "CBL binds to GRB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-169828", "l": "Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.2.2", "l": "\"oxazoline synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9675026", "l": "Formation of the MLL1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14718", "l": "D-erythrose 4-phosphate + H2O + phosphoenolpyruvate => 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68615", "l": "Formation of ORC(1-6) complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21297", "l": "D-galactose + NAD(+) => D-galactono-1,4-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0033721", "l": "aldehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70031", "l": "6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445071", "l": "Reinsertion of L1 into the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63836", "l": "hexadecanoate + O2 = (2R)-2-hydroperoxyhexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23812", "l": "(+)-neomenthol + NADP(+) = (1R,4S)-menthone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.208", "l": "\"(+)-neomenthol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008873", "l": "gluconate 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76089", "l": "a dicarboxylate(out) + kynurenate(in) => a dicarboxylate(in) + kynurenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189062", "l": "lactose + H2O => D-glucose + D-galactose (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74226", "l": "H2O + L-seryl-tRNA(Ala) <=> L-serine + tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18845", "l": "(R)-glycerate + NAD(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43532", "l": "a ribonucleoside 3',5'-bisphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate", "d": []}, {"i": "EC:3.1.3.97", "l": "\"3',5'-nucleoside bisphosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399939", "l": "Autophosphorylation of PAK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034004", "l": "germacradienol synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0052592", "l": "oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein."]}, {"i": "EC:1.17.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55450", "l": "a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33692", "l": "2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1247960", "l": "Activation of p38 MAPK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9761344", "l": "USP18 binds IKBKG within IKK complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46401", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38768", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005298", "l": "proline:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004729", "l": "oxygen-dependent protoporphyrinogen oxidase activity", "d": ["Catalysis of the reaction: 3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8934446", "l": "Activated PKC phosphorylates SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65162", "l": "CoA + hexan-2-yl benzoate => benzoyl-CoA + hexan-2-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29752", "l": "acetoacetate(in) => acetoacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10928", "l": "ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0004866", "l": "endopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of an endopeptidase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17142", "l": "glycine + oxaloacetate => glyoxylate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59345", "l": "D-maltose + O2 => D-maltobiono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69192", "l": "ATP + L-glutamate + L-glutamyl-[tubulin] = ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12530", "l": "[hyaluronan](n+1) + H(+) + UDP => N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53828", "l": "2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 = a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68072", "l": "Delta(2)-thiazoline-2-carboxylate + 2 H(+) + NADPH = L-thiazolidine-2-carboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74947", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2-oxoglutarate + O2 = (3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41368", "l": "1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69073", "l": "H2O + O2 + serotonin => (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26505", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose <=> 2 H(+) + ternatin C5 + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61444", "l": "a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44160", "l": "1D-myo-inositol 6-phosphate + H2O = myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32249", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168885", "l": "Haptoglobin binds Hemoglobin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44545", "l": "a fatty acid(out) + ATP + H2O => a fatty acid(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53089", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3927886", "l": "SUMOylation of NCOR2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031823", "l": "type 1D serotonin receptor binding", "d": ["Binding to a type 1D serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68428", "l": "lutein + O2 = (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R,6R)-hydroxy-alpha-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0016937", "l": "short-chain-acyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a short chain fatty acid residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35158", "l": "(S)-4,5-dihydroxypentane-2,3-dione <=> (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17990", "l": "ATP + L-seryl-[protein] => ADP + H(+) + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66377", "l": "D-erythrose 4-phosphate + H2O => D-erythrose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35335", "l": "H(+) + isopentadecanoyl-CoA + malonyl-CoA = 3-oxoisoheptadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16726", "l": "a phosphatidylglycerol phosphate + H2O => a phosphatidylglycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602624", "l": "Defective TRAF3 does not transmit the signal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73724", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate => (2R,3S,11S)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696547", "l": "STAMBPL1 is a deubiquitinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0045512", "l": "interleukin-26 binding", "d": ["Binding to interleukin-26."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73181", "l": "H(+) + S-adenosyl-L-homocysteine + scutellarein 4'-methyl ether => S-adenosyl-L-methionine + scutellarein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362485", "l": "GHBP binds GH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.14", "l": "\"bile-salt sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71786", "l": "3-methyl-2-oxobutanoate(out) + H(+)(out) <=> 3-methyl-2-oxobutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032582", "l": "Activated FYN binds GRIN2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15110", "l": "2-dehydro-3-deoxy-D-gluconate + NADP(+) => (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58932", "l": "4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH = 5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+)", "d": []}, {"i": "EC:2.3.1.289", "l": "\"aureothin polyketide synthase system\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69527", "l": "D-sorbitol + O2 <=> D-glucose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173723", "l": "C8 binds C5b:C6:C7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73681", "l": "3'-AMP(out) + ADP(in) + H(+)(in) => 3'-AMP(in) + ADP(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26486", "l": "H(+) + O-phospho-L-serine + sulfite = L-cysteate + phosphate", "d": []}, {"i": "EC:2.5.1.76", "l": "\"cysteate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48912", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a = CMP + ganglioside GT1a + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69140", "l": "N-(4-aminobutyl)-3-aminopropanal = acrolein + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1362416", "l": "Frataxin binds iron (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17331", "l": "(1R,4R)-camphor + H(+) + NADH => (1R,2S,4R)-borneol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24190", "l": "1,2-dihydroxydibenzothiophene + H(+) + NADH => cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003864", "l": "3-methyl-2-oxobutanoate hydroxymethyltransferase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000243", "l": "Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69481", "l": "an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21223", "l": "L-dopa + O2 <=> 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64339", "l": "H(+) + 2 malonyl-CoA + nicotinyl-CoA <=> 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299318", "l": "Activation of TASK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-996727", "l": "REST recruits the BHC complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709360", "l": "H2O2 reduces MetHb (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72370", "l": "estrone 3-sulfate(out) + succinate(in) <=> estrone 3-sulfate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70171", "l": "H(+)(in) + pemetrexed(in) = H(+)(out) + pemetrexed(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14038", "l": "4,5beta-dihydrocortisone + NADP(+) => cortisone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654603", "l": "Activated FGFR2 binds FRS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55590", "l": "a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51863", "l": "(2E)-geranyl diphosphate + umbelliferone <=> 8-geranylumbelliferone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679266", "l": "Beclin-1 complex translocates to the ER (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43693", "l": "ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004778", "l": "succinyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: H2O + succinyl-CoA = CoA + H+ + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684290", "l": "nsp3 is glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638006", "l": "ARL3 hydrolyzes GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56518", "l": "2 CO2 + 4 H2O + heme b => Fe-coproporphyrin III + 2 H(+) + 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71385", "l": "L-asparagine(out) + Na(+)(out) => L-asparagine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29620", "l": "alpha-maltotetraose + beta-maltose => alpha-maltopentaose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50264", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52175", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53377", "l": "5,6-dihydrouridine(16) in tRNA + NADP(+) => H(+) + NADPH + uridine(16) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17577", "l": "ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose", "d": []}, {"i": "EC:5.1.3.20", "l": "\"ADP-glyceromanno-heptose 6-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64667", "l": "a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350604", "l": "Agmatine + H2O <=> putrescine + urea (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419351", "l": "PAF receptor binds platelet activating factor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983150", "l": "Proteasomal cleavage of substrate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16724", "l": "5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450975", "l": "isocitrate <=> citrate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928607", "l": "p-EPHs bind VAV2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445079", "l": "Phosphorylation of L1 by ERK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58141", "l": "acetyl-AMP + cytidine(34) in elongator tRNA(Met) => AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187506", "l": "Translocation of p27 to the nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737710", "l": "SARS-CoV-1 N binds SMAD3 and EP300 at the SERPINE1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69537", "l": "alpha-D-tagatopyranose 1-phosphate + ATP => ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.64", "l": "\"caspase-11\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27968", "l": "6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate => 7,8-dihydroneopterin 3'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34446", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose <=> CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65534", "l": "2-methylbutyl hexanoate + CoA => 2-methylbutan-1-ol + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17021", "l": "(2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde", "d": []}, {"i": "EC:2.6.1.37", "l": "\"2-aminoethylphosphonate--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64019", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725332", "l": "MYC/MYCN bind the ALK gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61467", "l": "a cytidine in mRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47024", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O = [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332235", "l": "CBL binds TGFBR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21683", "l": "(2S)-2-hydroxyphytanate + O2 <=> 2-oxophytanate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191299", "l": "Squalene is oxidized to its epoxide (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13047", "l": "ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61425", "l": "cis-cis-nepetalactol + NAD(+) => cis-cis-nepetalactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034565", "l": "1-nitro-1,2-dihydro-1,3,5-triazine hydrolase activity", "d": ["Catalysis of the reaction: 1-nitro-1,2-dihydro-1,3,5-triazine + 2 H2O = 1-nitro-1,3,5-triazinane-2,4-diol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57052", "l": "3-oxoisoapionate + H(+) = CO2 + L-erythrulose", "d": []}, {"i": "EC:4.1.1.120", "l": "\"3-oxoisoapionate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37920", "l": "(9Z,12Z)-octadecadienoate + O2 => (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9659611", "l": "ANO1 inhibitors bind ANO1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008780", "l": "acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity", "d": ["Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008877", "l": "RUNX2:CBFB binds BGLAP gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47463", "l": "3-oxo-(5Z-tetradecenoyl)-CoA + CoA <=> (3Z)-dodecenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70006", "l": "6-oxocampestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> cathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9688459", "l": "RIPK3 binds HSP90:CDC37 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38969", "l": "ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate => an N-acylsphing-4-enine(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60214", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45041", "l": "2 Fe(III)-[cytochrome c] + hydroxylamine => 2 Fe(II)-[cytochrome c] + 2 H(+) + nitroxyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560472", "l": "Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71432", "l": "3,3',5'-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) => 3,3',5'-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59154", "l": "AMP + diphosphate + pseudomonoyl-CoA C => ATP + CoA + pseudomonate C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56923", "l": "a medium chain fatty acid + ATP + H(+) <=> a medium-chain fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28969", "l": "L-proline(out) + Na(+)(out) => L-proline(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59841", "l": "(6S)-5,6,7,8-tetrahydrofolate + syringate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60276", "l": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.355", "l": "\"[histone H3]-lysine(9) N-trimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388829", "l": "SHP2 phosphatase binds CTLA-4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34261", "l": "(+)-3'-hydroxylarreatricin + A + H2O => (+)-larreatricin + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32749", "l": "ethanolamine(out) => ethanolamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16937", "l": "1-O-alkyl-sn-glycerol + ATP = 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.93", "l": "\"alkylglycerol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15679", "l": "5-aminopentanoate + NH4(+) => 5-aminopentanamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31308", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2214351", "l": "PLK1 phosphorylates GORASP1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23649", "l": "dTDP-6-deoxy-beta-L-talose + NADP(+) => dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685681", "l": "Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11730", "l": "cyclopentanone + H(+) + NADH => cyclopentanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033827", "l": "high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the transfer of an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-1,6 to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798044", "l": "BTG2 binds CCR4-NOT complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429441", "l": "SYK activation by SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662613", "l": "MT3 exchanges zinc for copper (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13212", "l": "A + 3 H2O + trithionate <=> AH2 + 4 H(+) + 3 sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52729", "l": "3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate => a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64354", "l": "2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA => 3 H(+) + hexanoyl-CoA + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39734", "l": "3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32622", "l": "L-threo-7,8-dihydrobiopterin + NADP(+) <=> H(+) + NADPH + sepiapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49257", "l": "2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] => 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43075", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691131", "l": "CANDI binds CUL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18605", "l": "1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.65", "l": "\"scyllo-inosamine 4-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59664", "l": "D-cellopentaose + O2 = D-cellopentaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47143", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62716", "l": "stemphyloxin I = stemphyloxin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77609", "l": "Binding of APOBEC-1 to form editosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071576", "l": "tetrahydrodictyopterin binding", "d": ["Binding to tetrahydrodictyopterin, the pterin 2-amino-6-[(1R,2R)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21190", "l": "AMP + diphosphate + H(+) + NAD(+) => ATP + deamido-NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694563", "l": "ABHD10 hydrolyses MPAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9818682", "l": "MEN1 binds MLL2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64791", "l": "(E)-cinnamate + ATP + CoA <=> (E)-cinnamoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29225", "l": "dihydroxyacetone phosphate + menaquinol-8 => menaquinone-8 + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40944", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756574", "l": "SARS-CoV-2 S binds SFTPD 12mer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45182", "l": "2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine => 2 (E)-4-coumaroyl-CoA + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51252", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0050497", "l": "alkylthioltransferase activity", "d": ["Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.8.4.-", "l": "\"Transferring alkylthio groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23918", "l": "CO2 + UDP-alpha-D-xylose => H(+) + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051392", "l": "tRNA N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of a tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22109", "l": "L-threonine => 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578777", "l": "DMPK phosphorylates PLN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761025", "l": "ZEB2 and SP1 bind CDH11 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63997", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705584", "l": "HMGCR dimer binds statins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19512", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 2 H(+) + L-erythro-biopterin + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46269", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.4", "l": "\"trypsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848873", "l": "PTK6 phosphorylates ARAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712199", "l": "cAMP binds the olfactory CNG channel (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37631", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50265", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58096", "l": "1-tetracosanoylglycerol + H2O = glycerol + H(+) + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379387", "l": "COMT transfers Met to DA to form 3MT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015660", "l": "formate efflux transmembrane transporter activity", "d": ["Enables the transfer of formate from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948136", "l": "ULK1 Translocates to the mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.13", "l": "\"ornithine aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15649", "l": "carbamate + 2 H(+) = CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637635", "l": "esxA binds B2M (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201443", "l": "Type II receptor phosphorylates type I receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686430", "l": "MUS81 binds EME1, EME2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849900", "l": "SALMs1-3 bind each other in cis interactions (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928656", "l": "gamma-secretase cleaves EPHB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74059", "l": "PDE6 hydrolyses cGMP to GMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24093", "l": "2 H(+) + O2 + 2 sulochrin => 2 (2S)-bisdechlorogeodin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853496", "l": "SCF:FBXL7 binds AURKA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41069", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30077", "l": "cytosine + D-ribose 5-phosphate => CMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53575", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64071", "l": "(R)-phenylacetylcarbinol + NAD(+) <=> 1-phenyl-1,2-propanedione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9032798", "l": "DOCK3 activates RAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18609", "l": "carbamoyl phosphate + N(2)-acetyl-L-ornithine = H(+) + N(2)-acetyl-L-citrulline + phosphate", "d": []}, {"i": "EC:2.1.3.9", "l": "\"N-acetylornithine carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9681616", "l": "AP2 binds chlorpromazine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050086", "l": "mannitol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72466", "l": "L-threonyl-[protein] + NAD(+) <=> H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10043", "l": "adenosine 3',5'-bisphosphate + H2O <=> AMP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186773", "l": "PDGF dimer binds two receptors simultaneously (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187211", "l": "Splicing of HIV RNA transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-555065", "l": "Formation of clathrin coated vesicle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38474", "l": "L-histidine + 3 S-adenosyl-L-methionine <=> 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031783", "l": "type 5 melanocortin receptor binding", "d": ["Binding to a type 5 melanocortin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12378", "l": "ADP + H(+) + L-fuculose 1-phosphate => ATP + L-fuculose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10111", "l": "(7S)-salutaridinol + NADP(+) <=> H(+) + NADPH + salutaridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202248", "l": "Phosphorylation of PLC-gamma1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604308", "l": "NICD4 traffics to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686430", "l": "MUS81 binds EME1, EME2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22033", "l": "3-oxalomalate => glyoxylate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168885", "l": "Haptoglobin binds Hemoglobin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43744", "l": "ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)", "d": []}, {"i": "EC:6.3.4.19", "l": "\"tRNA(Ile)-lysidine synthetase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676255", "l": "Formation of the MLL2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36991", "l": "phosphate + UMP = alpha-D-ribose 1,5-bisphosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24024", "l": "(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine", "d": []}, {"i": "EC:2.6.1.115", "l": "\"5-hydroxydodecatetraenal 1-aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190261", "l": "FGFR3c binds to FGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45514", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[C-phycocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(155)-[C-phycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018653", "l": "3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity", "d": ["Catalysis of the reaction: 3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59191", "l": "L-histidine <=> D-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66639", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (-)-alpha-acorenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852010", "l": "BTNL2 binds activated T cells surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26379", "l": "cyclic pyranopterin phosphate + diphosphate => GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199154", "l": "CD200 binds to CD200R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25511", "l": "(2E)-geranyl diphosphate <=> (1S,5S)-sabinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9663511", "l": "BIL binds GSTA1, FABP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29806", "l": "ATP + H2O + L-valine(out) <=> ADP + H(+) + L-valine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080054", "l": "low-affinity nitrate transmembrane transporter activity", "d": ["Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72889", "l": "ascocorynin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + polyporic acid + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68785", "l": "(2Z,6Z)-farnesyl diphosphate => diphosphate + gamma-curcumene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0050626", "l": "trimethylamine-N-oxide reductase (cytochrome c) activity", "d": ["Catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950456", "l": "IL12B dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404144", "l": "Parenchymal atROL translocates to HSCs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11045", "l": "a haloacetate + H2O => a halide anion + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40068", "l": "2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O => 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51118", "l": "H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine => guanosine(6) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61440", "l": "acetyl-CoA + S-(2-succino)-L-cysteine = CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004951", "l": "cholecystokinin receptor activity", "d": ["Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24783", "l": "C-13(2)-carboxypyropheophorbide a + H(+) <=> CO2 + pyropheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005118", "l": "sevenless binding", "d": ["Binding to a sevenless (sev) protein, a receptor tyrosine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173631", "l": "Activation of C1s (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004312", "l": "fatty acid synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046981", "l": "beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the transfer of N-acetylglucosamine (GlcNAc) in a beta-1,3 linkage to the mannose(beta-1,4)Glc disaccharide core of glycolipids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47044", "l": "3-dehydrocarnitine + acetyl-CoA = acetoacetate + N,N,N-trimethylglycyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018751", "l": "3,5-dichlorophenylcarboximide hydrolase activity", "d": ["Catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68537", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-cedrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71579", "l": "CDP(out) + CDP-L-ribitol(in) = CDP(in) + CDP-L-ribitol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20443", "l": "3-sulfino-L-alanine + H(+) => L-cysteine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23995", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374251", "l": "DARC  is a non-specific receptor for many chemokines (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23568", "l": "(2E)-decenoyl-[ACP] = (3Z)-decenoyl-[ACP]", "d": []}, {"i": "EC:5.3.3.14", "l": "\"trans-2-decenoyl-[acyl-carrier-protein] isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44957", "l": "(2E)-hexenoyl-CoA + H(+) + NADPH => hexanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24177", "l": "[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62793", "l": "3 H(+) + NADPH + O2 + 2 rubrofusarin B => 2 H2O + NADP(+) + nigerone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14271", "l": "2 a 1,4-benzosemiquinone + NADP(+) => 2 a quinone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68333", "l": "(R)-4'-phosphopantothenate + H2O => (R)-pantothenate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174119", "l": "Free APC/C phosphorylated by Plk1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0002094", "l": "polyprenyltransferase activity", "d": ["Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139909", "l": "Translocation of BMF to mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37248", "l": "H2O + thymidine 3'-monophosphate => phosphate + thymidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15621", "l": "an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.122", "l": "\"N-acetylgalactosaminide beta-1,3-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54257", "l": "2-oxoglutarate + L-histidyl-[protein] + O2 => (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388808", "l": "CD28 homodimer binds B7-2 monomer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033944", "l": "beta-galactofuranosidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing beta-D-galactofuranosides, releasing galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000310", "l": "AURKA phosphorylates PLK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693061", "l": "STAMBP binds STAM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48805", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61358", "l": "ADP + H(+) + methotrexate(out) + phosphate => ATP + H2O + methotrexate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61924", "l": "(2S,4R)-ketoconazole(in) + ATP + H2O = (2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52303", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62989", "l": "dodecanamide + H2O => dodecanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24039", "l": "a ribonucleoside 5'-phosphate + ATP <=> a ribonucleoside 5'-diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690196", "l": "USP8 deubiquitinates RNF128 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29576", "l": "L-serine(in) + Na(+)(in) => L-serine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-844447", "l": "NLRP1 senses MDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647978", "l": "pro-RAS proteins are farnesylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210805", "l": "Removal of miRNA passenger strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170846", "l": "TGFBR2 recruits TGFBR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202966", "l": "Caspase mediated cleavage of HIP-55 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53822", "l": "7-oxolithocholate + H(+) + NADPH => chenodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.378002841413903", "identifiers": [{"i": "GO:0016620", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130619", "l": "TGN-lysosomal vesicle coat assembly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848774", "l": "PTK6 binds DOK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390425", "l": "FAR1 reduces PalmCoA to HXOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13761", "l": "L-methionine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine", "d": []}, {"i": "EC:2.1.1.12", "l": "\"methionine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097627", "l": "high-affinity L-ornithine transmembrane transporter activity", "d": ["Enables the transfer of L-ornithine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614271", "l": "Autocleavage of ADGRG6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102772", "l": "sphingolipid long-chain base 4-hydroxylase activity", "d": ["Catalysis of the reaction: O2 + H+ + a dihydroceramide + NAD(P)H = H2O + a phytoceramide + NAD(P)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828034", "l": "SOX17 binds the CXCR4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52159", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0008376", "l": "acetylgalactosaminyltransferase activity", "d": ["Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14852", "l": "H2O + N-amidino-L-aspartate <=> L-aspartate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051724", "l": "NAD transmembrane transporter activity", "d": ["Enables the transfer of NAD from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68445", "l": "5-cis-lycopene + O2 => (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42881", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermine => H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35808", "l": "2-dehydro-3-deoxy-D-arabinonate => 2,5-dioxopentanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0052618", "l": "coenzyme F420-0:L-glutamate ligase activity", "d": ["Catalysis of the reaction: GTP + L-glutamate + factor F420-0 = GDP + H+ + factor gamma-F420-1 + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54040", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (3E,7E)-dolathalia-3,7,11-triene + diphosphate", "d": []}, {"i": "EC:4.2.3.168", "l": "\"dolathalia-3,7,11-triene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061654", "l": "NEDD8 conjugating enzyme activity", "d": ["Isoenergetic transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both the X-NEDD8 and Y-NEDD8 linkages are thioester bonds between the C-terminal amino acid of NEDD8 and a sulfhydryl side group of a cysteine residue."]}, {"i": "EC:2.3.2.34", "l": "\"E2 NEDD8-conjugating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38290", "l": "(3S)-citramalate + succinyl-CoA <=> (3S)-citramalyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49376", "l": "12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35099", "l": "fusidate(in) + H(+)(out) = fusidate(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55191", "l": "5-methyluridine(54) in tRNA + ATP + hydrogen sulfide <=> 5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21597", "l": "L-serine + NADP(+) => 2-aminomalonate semialdehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983153", "l": "E1 mediated ubiquitin activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.760111289607934", "identifiers": [{"i": "GO:0043169", "l": "cation binding", "d": ["Binding to a cation, a charged atom or group of atoms with a net positive charge."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54025", "l": "2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 => (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448673", "l": "Formation of caspase-1 p10/p20 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004848", "l": "ureidoglycolate hydrolase activity", "d": ["Catalysis of the reaction: (S)-ureidoglycolate + H2O + 2 H+ = CO2 + glyoxylate + 2 NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380294", "l": "Loss of C-Nap-1 from centrosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49943", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 <=> (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0008417", "l": "fucosyltransferase activity", "d": ["Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid."]}, {"i": "REACT:R-HSA-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202713", "l": "CD84 homodimerises (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177284", "l": "PKA phosphorylates PDE4B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16380", "l": "(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046565", "l": "3-dehydroshikimate dehydratase activity", "d": ["Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52745", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + H2O => alpha-isomaltosyl-(1->3)-isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004756", "l": "selenide, water dikinase activity", "d": ["Catalysis of the reaction: ATP + H2O + hydrogen selenide = AMP + 3 H+ + phosphate + selenophosphorate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351871", "l": "Caspase-mediated cleavage of Z0-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45788", "l": "(9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol = 1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111883", "l": "Hydrolysis of phosphatidylcholine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42935", "l": "cytidine(32) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65587", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17651", "l": "acetate + malonyl-[ACP] => acetyl-[ACP] + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381644", "l": "ER calcium channels open in response to activated PKA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112396", "l": "Separation of elongating transcript from template (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.713784635685485", "identifiers": [{"i": "GO:0061733", "l": "peptide-lysine-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16354", "l": "2-oxoglutarate + taurine => L-glutamate + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28887", "l": "H(+)(in) + L-serine(in) = H(+)(out) + L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701488", "l": "Active ALK phosphorylates JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28693", "l": "a ubiquinol + orotate => (S)-dihydroorotate + a ubiquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18761", "l": "a 1,2-diacyl-sn-glycerol + H2O = a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64243", "l": "glycine + octanoyl-CoA <=> CoA + H(+) + N-octanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16333", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] = diphosphate + holo-[citrate lyase ACP]", "d": []}, {"i": "EC:2.7.7.61", "l": "\"citrate lyase holo-[acyl-carrier protein] synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12478", "l": "formate + L-glutamate => H2O + N-formyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42506", "l": "6-acetamido-2-oxohexanoate + L-glutamate => 2-oxoglutarate + N(6)-acetyl-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41083", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731708", "l": "nsp10:nsp14 binds to ExoN inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418863", "l": "Shp2 binds pUnc5C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675790", "l": "MTORC1 dissociates from ULK complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34669", "l": "20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => C30 botryococcene + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080103", "l": "4-methylthiopropyl glucosinolate S-oxygenase activity", "d": ["Catalysis of the reaction: 4-methylthiopropyl-glucosinolate = 4-methylsulfinylpropyl-glucosinolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15629", "l": "a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] = an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin]", "d": []}, {"i": "EC:1.14.15.4", "l": "\"steroid 11beta-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70135", "l": "6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11732", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B = H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.142", "l": "\"8-dimethylallylnaringenin 2'-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40554", "l": "demethylphylloquinol + S-adenosyl-L-methionine <=> H(+) + phylloquinol + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030372", "l": "high molecular weight B cell growth factor receptor binding", "d": ["Binding to a high molecular weight B cell growth factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264834", "l": "Endocytosis and degradation of apoA-I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25124", "l": "(S)-2-amino-6-oxohexanoate <=> H(+) + H2O + L-1-piperideine-6-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14333", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol = 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": []}, {"i": "EC:4.6.1.14", "l": "\"glycosylphosphatidylinositol diacylglycerol-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416516", "l": "GRK2 sequesters activated Gq (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73814", "l": "L-proline(in) <=> L-proline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21697", "l": "N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047455", "l": "16-alpha-hydroxyprogesterone dehydratase activity", "d": ["Catalysis of the reaction: 16-alpha-hydroxyprogesterone = H2O + 16-dehydroprogesterone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5213464", "l": "RIPK1 is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.5", "l": "\"nucleoside ribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38438", "l": "(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70113", "l": "28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008670", "l": "2,4-dienoyl-CoA reductase (NADPH) activity", "d": ["Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43324", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21496", "l": "dimethylallyl diphosphate + H2O = diphosphate + prenol", "d": []}, {"i": "EC:3.1.7.1", "l": "\"prenyl-diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687105", "l": "IGF2BP1 represses translation of MAPK4 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37378", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34894", "l": "selenite(in) <=> selenite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36704", "l": "(2S,5S)-5-carboxymethylproline + ATP => (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69953", "l": "3-dehydroteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12909", "l": "2 Fe(II)-[cytochrome] + 2 H(+) + nitrate = 2 Fe(III)-[cytochrome] + H2O + nitrite", "d": []}, {"i": "EC:1.9.6.1", "l": "\"nitrate reductase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210271", "l": "Interaction of DAP12 and MDL-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60685", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) => (11R)-dihydroartemisinate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35767", "l": "dihydrosterigmatocystin + S-adenosyl-L-methionine = 8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13994", "l": "(S)-3-amino-2-methylpropanoate + 2-oxoglutarate => 2-methyl-3-oxopropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67587", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62394", "l": "3-dehydrolevoglucosan + H(+) + NADH => levoglucosan + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29584", "l": "guanosine(in) + H(+)(out) => guanosine(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371590", "l": "HSP70 binds to HSP40:nascent protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33566", "l": "(4R)-hydroxysphinganine + ATP <=> (4R)-hydroxysphinganine 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50084", "l": "ATP + H2O + taurolithocholate 3-sulfate(in) = ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362437", "l": "C-terminal Hh fragments are bound by lectins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28257", "l": "(3Z)-hex-3-en-1-ol + acetyl-CoA <=> (3Z)-hex-3-en-1-yl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14820", "l": "4-maleylacetoacetate <=> 4-fumarylacetoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63864", "l": "O2 + octadecanoate = (2R)-2-hydroperoxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17281", "l": "(2S)-4-acetamido-2-aminobutanoate = H2O + L-ectoine", "d": []}, {"i": "EC:4.2.1.108", "l": "\"ectoine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202969", "l": "Caspase mediated cleavage of beta-catenin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45246", "l": "(2E,4E)-octadienoyl-CoA => (3E,5Z)-octadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213208", "l": "Type X collagen associates with collagen type II fibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75145", "l": "solanapyrone D => prosolanapyrone III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19192", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate <=> (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74831", "l": "UDP-alpha-D-glucuronate(out) + UDP-alpha-D-xylose(in) = UDP-alpha-D-glucuronate(in) + UDP-alpha-D-xylose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53499", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20906", "l": "(S)-1,2-epoxypropane + coenzyme M => (S)-2-hydroxypropyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70406", "l": "(9Z)-hexadecenoyl-CoA + 3-oxosphinganine <=> CoA + H(+) + N-(9Z-hexadecenoyl)-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0015112", "l": "nitrate transmembrane transporter activity", "d": ["Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other."]}, {"i": "RHEA:34923", "l": "nitrate(in) = nitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48207", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA <=> (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592240", "l": "Formation of NRF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40041", "l": "2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate => 2 ATP + 2 L-glutamate + N-acetyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656259", "l": "Defective HEXA does not cleave the terminal GalNAc from DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418925", "l": "ADORA2A,B bind Ade-Rib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691174", "l": "RAC1 binds effectors at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40985", "l": "(9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+) => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0046403", "l": "polynucleotide 3'-phosphatase activity", "d": ["Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796626", "l": "MIB2 ubiquitinates CFLAR  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53896", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+)", "d": []}, {"i": "EC:2.4.3.7", "l": "\"alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46009", "l": "CoA + NAD(+) + pentanal => H(+) + NADH + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42355", "l": "(R)-nicotine + A + H2O <=> (R)-6-hydroxynicotine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14843", "l": "ent-copalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13115", "l": "H(+) + N-hydroxy-2-acetamidofluorene + NADPH => 2-acetamidofluorene + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56381", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 => (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015127", "l": "bilirubin transmembrane transporter activity", "d": ["Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40226", "l": "4,8-dimethylnonanoyl-CoA + H2O <=> 4,8-dimethylnonanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27336", "l": "6-hydroxynicotinate + 2 H(+) + NADH + O2 <=> 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449811", "l": "IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12867", "l": "1-methyladenine + D-ribose => 1-methyladenosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015208", "l": "guanine transmembrane transporter activity", "d": ["Enables the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380782", "l": "STAT binds to the active receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66994", "l": "3-methylpentanoyl-CoA + AMP + diphosphate => 3-methylpentanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53456", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809707", "l": "MTMR12 binds MTMR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34702", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-isocomene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56802", "l": "cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29562", "l": "H2O + UDP-alpha-D-glucuronate <=> 1-phospho-alpha-D-glucuronate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15805", "l": "(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate", "d": []}, {"i": "EC:6.3.3.3", "l": "\"dethiobiotin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046919", "l": "pyruvyltransferase activity", "d": ["Catalysis of the transfer of a pyruvyl (oxopropanoyl) group from one compound to another."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69415", "l": "2 glutathione + tert-butyl hydroperoxide <=> glutathione disulfide + H2O + tert-butanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660980", "l": "p-S276-RELA binds RELB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19540", "l": "D-mannitol 1-phosphate + H2O <=> D-mannitol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237160", "l": "MTA is cleaved and phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19778", "l": "A + L-pipecolate => AH2 + H(+) + L-1-piperideine-6-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57803", "l": "2,3-dinitrotoluene + NADH + O2 <=> 4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66845", "l": "asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase] => asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30210", "l": "H2O + methylamine + 2 oxidized [amicyanin] <=> formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865454", "l": "CBFB binds RUNX3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35672", "l": "(S)-5'-oxoaverantin + H(+) => (1'S,5'S)-averufin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61256", "l": "H2O + L-cysteine + O2 = 2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682026", "l": "MRN bound to shortened telomeres activates ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604731", "l": "Autocatalytic activation of MMP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45143", "l": "2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O <=> CO2 + L-glutamyl-[protein] + O2 + phylloquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5660660", "l": "p300 acetylates RELA subunit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22654", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate => 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0005041", "l": "low-density lipoprotein particle receptor activity", "d": ["Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8873946", "l": "OTUD3 deubiquitinates PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14326", "l": "7,8-dihydroxycoumarin + UDP-alpha-D-glucose => daphnin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592314", "l": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17652", "l": "acetyl-[ACP] + malonate <=> acetate + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578712", "l": "Importin-8 binds AGO2:miRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16357", "l": "A + succinate = AH2 + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211924", "l": "CYP4B1 12-hydroxylates ARA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021951", "l": "OPRK1 gene expression is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.76", "l": "\"flavastacin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449117", "l": "TXLNA (IL14) binds syntaxin1A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11460", "l": "ADP + D-glucose = AMP + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34746", "l": "15-methylhexadecasphinganine 1-phosphate <=> 13-methyltetradecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51664", "l": "D-5-phenylhydantoin + H2O = H(+) + N-carbamoyl-D-phenylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50855", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72188", "l": "H(+)(out) + sucrose(out) => H(+)(in) + sucrose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46685", "l": "3-oxochol-4-en-24-oyl-CoA + A => (22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14497", "l": "A + pyridoxine = AH2 + isopyridoxal", "d": []}, {"i": "EC:1.1.99.9", "l": "\"pyridoxine 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55679", "l": "chorismate + NH4(+) <=> (2S)-2-amino-4-deoxychorismate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654533", "l": "KRAS4B recycles to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709547", "l": "ESTG binds ESR2:chaperone complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75333", "l": "chloride(in) + D-methionine(in) + 2 Na(+)(in) => chloride(out) + D-methionine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168875", "l": "Trimerization of HA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23971", "l": "(E)-coniferaldehyde + H2O + NAD(+) <=> (E)-ferulate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.706056554619465", "identifiers": [{"i": "GO:1904680", "l": "peptide transmembrane transporter activity", "d": ["Enables the transfer of a peptide from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-1500817", "l": "Glutathione is taken up by the bacterium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050632", "l": "propionyl-CoA C2-trimethyltridecanoyltransferase activity", "d": ["Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59472", "l": "2',3'-cGAMP + H2O = Gp(2'-5')Ap(3') + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49040", "l": "(-)-5'-demethylyatein + S-adenosyl-L-methionine = (-)-yatein + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.330", "l": "\"5'-demethylyatein 5'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75342", "l": "chloride(out) + nitrate(in) <=> chloride(in) + nitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25781", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine => 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58474", "l": "CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149519", "l": "MMACHC decyanates CNCbl (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102199", "l": "nitric oxide reductase activity (NAD(P)H-dependent) activity", "d": ["Catalysis of the reaction: dinitrogen oxide + H2O + NAD(P) = 2 nitric oxide + H+ + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41725", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2467775", "l": "Autocleavage of ESPL1 (Separase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58287", "l": "5,6-dihydrothymine + NADP(+) <=> H(+) + NADPH + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68176", "l": "2-oxoglutarate + N-geranyl-L-glutamate + O2 = CO2 + dainate A + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10329", "l": "an L-glycol + NAD(+) => a 2-hydroxycarbonyl + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874685", "l": "CBL binds MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20429", "l": "apigenin + S-adenosyl-L-methionine = acacetin + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.75", "l": "\"apigenin 4'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662598", "l": "MT2A binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948621", "l": "miR-20 microRNAs bind VAPA mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40084", "l": "hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52057", "l": "12-hexadecanoyloxy-octadecanoate + H2O => 12-hydroxyoctadecanoate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1878002", "l": "XYLTs transfer Xyl to core protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38858", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72362", "l": "glutarate(in) + succinate(out) <=> glutarate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102028", "l": "cystathionine gamma-synthase activity (acts on O-phosphohomoserine)", "d": ["Catalysis of the reaction: L-cysteine + O-phosphonato-L-homoserine = L-cystathionine + hydrogenphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59135", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP <=> AMP + diphosphate + H(+) + staphyloferrin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29868", "l": "AMP + ITP => ADP + IDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71849", "l": "LDH tetramer reduces PYR to LACT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735276", "l": "Expression of HAND1 in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050364", "l": "tryptophan dimethylallyltransferase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112396", "l": "Separation of elongating transcript from template (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53398", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+) => a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65108", "l": "aculene C + L-prolyl-[peptidyl-carrier protein] = aculene A + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332363", "l": "Autophosphorylation and activation of CAMK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218822", "l": "CRK binds BCAR1 and or PXN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10128", "l": "all-trans-violaxanthin = all-trans-neoxanthin", "d": []}, {"i": "EC:5.3.99.9", "l": "\"neoxanthin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34928", "l": "H(+) + NADPH + selenodiglutathione => glutathione + glutathioselenol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863494", "l": "ASICs bind STOML3, (STOM) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73440", "l": "(2S)-naringenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-carthamidin-4',7-dimethyl ether + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10176", "l": "(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) = (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.397", "l": "\"beta-methylindole-3-pyruvate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29263", "l": "L-leucine(in) + Na(+)(in) = L-leucine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17228", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] <=> 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044022", "l": "histone H3S28 kinase activity", "d": ["Catalysis of the reaction: histone H3-serine (position 28) + ATP = histone H3-phosphoserine (position 28) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 28 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222363", "l": "MsrA/B reduces peptide-methionine S/R-sulfoxides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12044", "l": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22294", "l": "biphenyl-3,5-diol + 4 CO2 + 4 CoA => benzoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41357", "l": "bacteriochlorophyll a + 3 NADP(+) => geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604731", "l": "Autocatalytic activation of MMP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13288", "l": "ATP + L-cysteine + L-glutamate <=> ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60154", "l": "L-glutamate + L-glutamyl-[protein] => gamma-L-glutamyl-L-glutamyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19544", "l": "L-glutamate 5-semialdehyde + NADP(+) + phosphate <=> H(+) + L-glutamyl 5-phosphate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626253", "l": "HSPA8 binds LAMP2a multimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59588", "l": "ATP + beta-alanine + L-ornithine = ADP + beta-alanyl-L-ornithine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65676", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine = a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662114", "l": "ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63736", "l": "2-phenylacetaldehyde + H(+) + NADPH = 2-phenylethanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2327746", "l": "FN1 aggregation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20681", "l": "cis-zeatin + UDP-alpha-D-glucose = H(+) + O-beta-D-glucosyl-cis-zeatin + UDP", "d": []}, {"i": "EC:2.4.1.215", "l": "\"cis-zeatin O-beta-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-901047", "l": "Binding of ERp57 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65016", "l": "chlorothalonil + H2O = 4-hydroxychlorothalonil + chloride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66802", "l": "2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase] => miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22337", "l": "glycine betaine + L-homocysteine => L-methionine + N,N-dimethylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018521", "l": "1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD+ = 3-methylcatechol + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49333", "l": "2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60721", "l": "(E)-hept-2-enal + H2O + NADP(+) => (E)-hept-2-enoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70790", "l": "H(+)(in) + L-citrulline(in) + L-ornithine(out) <=> H(+)(out) + L-citrulline(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67034", "l": "4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60412", "l": "H2O + monoglucosyl-enterobactin = [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201603", "l": "Caspase-mediated cleavage of PKC theta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28197", "l": "(2S)-3-sulfolactate + NAD(+) <=> 3-sulfopyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620813", "l": "RBL2 gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250264", "l": "TXNIP binds reduced thioredoxin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68101", "l": "NAD(+) + xylitol => H(+) + L-xylulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004470", "l": "malic enzyme activity", "d": ["Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989771", "l": "Expression of TNFRSF21 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2399913", "l": "atRAL binds to RBP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866269", "l": "ARRB bind GPCRs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202394", "l": "Translocation of CARMA1 to Plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678981", "l": "TLR9 processing at neutral pH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63073", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA => 4 CO2 + 4 CoA + orcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28748", "l": "NH4(+)(in) => NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37907", "l": "(9Z)-octadecenoate + O2 = (8E,10S)-10-hydroperoxy-octadeca-8-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31783", "l": "H2O + tuberculosinyl diphosphate = diphosphate + tuberculosinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23869", "l": "(1-hydroxycyclohexan-1-yl)acetyl-CoA => acetyl-CoA + cyclohexanone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102290", "l": "beta-amyrin monooxygenase activity", "d": ["Catalysis of the reaction: beta-amyrin + O2 + NADPH + H+ <=> 11alpha-hydroxy-beta-amyrin + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24365", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) => 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47543", "l": "7-oxolithocholate + H(+) + NADPH <=> NADP(+) + ursodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429714", "l": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75993", "l": "a dicarboxylate(out) + N-benzoylglycine(in) => a dicarboxylate(in) + N-benzoylglycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389919", "l": "Grb2 binds pBTLA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.-", "l": "\"Acting on phosphates\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59442", "l": "(S)-isodihydrodehydrodiconiferyl alcohol + NADP(+) => (-)-dehydrodiconiferyl alcohol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27806", "l": "acetoacetate + acetyl-CoA = acetate + acetoacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798257", "l": "PTPRS binds NTRK3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.38", "l": "\"beta-D-fucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797100", "l": "CCNK binds CDK13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23411", "l": "NADP(+) + precorrin-6B <=> 2 H(+) + NADPH + precorrin-6A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58711", "l": "rifampicin ortho-naphthoquinone carboxamide <=> rifampicin para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626816", "l": "PIN1 binds p-S345-NCF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55637", "l": "ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O => AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25541", "l": "ent-copalyl diphosphate => diphosphate + ent-pimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16272", "l": "aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) <=> 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70454", "l": "2-oxoglutarate + an N(1)-ethyl-2'-deoxyadenosine in single-stranded DNA + O2 <=> a 2'-deoxyadenosine in single-stranded DNA + acetaldehyde + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58998", "l": "H(+) + H2O2 + indole-3-carboxylate => H2O + indole-3-carbaldehyde + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61962", "l": "a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31716", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.159", "l": "\"dolabradiene monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71564", "l": "5-aminomethyl-dUMP in DNA + acetyl-CoA => 5-acetylaminomethyl-dUMP in DNA + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0044390", "l": "ubiquitin-like protein conjugating enzyme binding", "d": ["Binding to a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31699", "l": "4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] = 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": []}, {"i": "EC:1.14.15.32", "l": "\"pentalenene oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57341", "l": "3-hydroxy-L-kynurenine + S-adenosyl-L-methionine => 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9823816", "l": "OPTN binds CASP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9749215", "l": "MCM8 binds CDC6 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74730", "l": "Insulin degradation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53703", "l": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139906", "l": "Activation of BAD by calcineurin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73930", "l": "griseophenone D + S-adenosyl-L-methionine <=> griseophenone C + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731002", "l": "CLCN3 exchanges Cl- for H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47081", "l": "17beta-hydroxyestr-4-en-3-one + H(+) + NADPH => 17beta-hydroxy-5beta-estran-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043015", "l": "gamma-tubulin binding", "d": ["Binding to the microtubule constituent protein gamma-tubulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12519", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-(R)-germacrene A + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67698", "l": "CoA + H(+) + hexadecanedioate => H2O + hexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602901", "l": "Defective GSS does not synthesize GSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801776", "l": "REG3A binds bacterial phospholipids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55106", "l": "(3R)-hydroxyheptanoyl-[ACP] + NADP(+) => 3-oxoheptanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46789", "l": "a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862380", "l": "HSD17B13 binds lipid droplets (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49881", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757688", "l": "SERPINA6 binds PREDN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30061", "l": "orotate + succinate => (S)-dihydroorotate + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29496", "l": "(2E,6E)-farnesyl diphosphate + H2O => beta-eudesmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41960", "l": "ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GA1 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671876", "l": "Phosphorylated STAT5 Dissociates from Leptin Receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49083", "l": "dibenzothiophene 5-oxide + FMNH2 + O2 <=> dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703436", "l": "STAT5-dependent PIM1 gene expression downstream of FLT3 ITD and fusion mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793975", "l": "Expression of GATA3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18331", "l": "(1S,5S)-sabinone + H(+) + NADH => (1S,3R,5S)-sabinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45412", "l": "H2O + prostaglandin D2-1-glycerol ester = glycerol + H(+) + prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20251", "l": "D-alanine => L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212642", "l": "L-Glutamine transport into neurons (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67894", "l": "3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24516", "l": "acetyl-CoA + gentamicin C1a = CoA + H(+) + N(2')-acetylgentamicin C1a", "d": []}, {"i": "EC:2.3.1.59", "l": "\"gentamicin 2'-N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614933", "l": "ACEIs bind ACE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10906", "l": "AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide => [cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030274", "l": "LIM domain binding", "d": ["Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57979", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose <=> (20S)-ginsenoside C-K + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391934", "l": "DP2 receptor can bind PGD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009936", "l": "RNASEL cleaves cellular ssRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43041", "l": "hexadecanoyl-CoA + hexadecasphinganine => CoA + H(+) + N-hexadecanoylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30769", "l": "D-glucuronate + H(+) => D-glucurono-3,6-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70112", "l": "6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.590029142468794", "identifiers": [{"i": "GO:0019783", "l": "ubiquitin-like protein peptidase activity", "d": ["An isopeptidase activity that cleaves ubiquitin or ubiquitin-like proteins (ULP; e.g. ATG8, ISG15, NEDD8, SUMO) from target proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62327", "l": "(+)-malbrancheamide B + chloride + FAD + 2 H(+) <=> (+)-malbrancheamide + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44706", "l": "a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58041", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O => (9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50353", "l": "3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH => 3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44086", "l": "AMP + diphosphate + heptadecanoyl-CoA => ATP + CoA + heptadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65350", "l": "3-oxochol-4,6-dien-24-oyl-CoA + H2O => 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59563", "l": "H2O + N,N',N''-triacetylchitotriono-1,5-lactone <=> H(+) + N,N',N''-triacetylchitotrionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382055", "l": "Grb7 binds to the active PDGF receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199579", "l": "KIR2DL4 interacting with HLA-G (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53118", "l": "an 11-oxosteroid + H(+) + NADH => an 11beta-hydroxysteroid + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65382", "l": "a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59833", "l": "ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40526", "l": "a quinone + succinate <=> a quinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63937", "l": "3 a ubiquinone + protoporphyrinogen IX => 3 a ubiquinol + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48018", "l": "2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite => 4-methyl-5-nitrocatechol + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050809", "l": "diazepam binding", "d": ["Binding to diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212432", "l": "Formation of DRIP coactivator complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45965", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O => 2 AMP + ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41021", "l": "1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102249", "l": "phosphatidylcholine:diacylglycerol cholinephosphotransferase activity", "d": ["Catalysis of the reaction: a phosphatidylcholine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a phosphatidylcholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33846", "l": "H2O + N-tetracosanoylsphinganine <=> sphinganine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28904", "l": "D-alanine(in) + H(+)(in) => D-alanine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53050", "l": "2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-hydroxyestrone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42310", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22094", "l": "15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => (3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051751", "l": "alpha-1,4-mannosyltransferase activity", "d": ["Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->4) linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27592", "l": "(R)-pantothenate + ADP + H(+) + phosphate => (R)-pantoate + ATP + beta-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913374", "l": "Phosphorylated SHC1 recruits SHIP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75238", "l": "TRAIL binds TRAIL receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786155", "l": "POLN binds ICL-DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909776", "l": "beta-alanine + pyruvate => 3-oxopropanoate + alanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086393", "l": "G alpha t2 binds and activates PDE6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64030", "l": "H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69480", "l": "an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.386", "l": "\"GlcNAc-beta-1,3-Gal beta-1,6-N-acetylglucosaminyltransferase (distally acting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64244", "l": "a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22355", "l": "H(+) + L-lysine <=> cadaverine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59659", "l": "D-cellotriose + O2 <=> D-cellotriono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3928619", "l": "PAK1 binds RAC1:GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69584", "l": "GMP + inosine = guanosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67435", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29759", "l": "octanoate(in) = octanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.11", "l": "\"dextranase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62832", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40045", "l": "ADP + beta-citrylglutamate + H(+) + phosphate => ATP + citrate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69152", "l": "Removal of remaining Flap (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48062", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17011", "l": "2-succinylbenzoyl-CoA + AMP + diphosphate => 2-succinylbenzoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.5.1", "l": "\"sesamin methylene transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10816", "l": "H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside", "d": []}, {"i": "EC:3.2.1.63", "l": "\"1,2-alpha-L-fucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015341", "l": "zinc efflux active transmembrane transporter activity", "d": ["Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane: Zn2+(out) = Zn2+(in). The activity is driven by proton motive force."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47375", "l": "a quinone + D-glucose <=> a quinol + D-glucono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68571", "l": "N(5)-hydroxy-L-ornithine <=> (3S)-1,2-diazinane-3-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54010", "l": "(8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0000721", "l": "(R,R)-butanediol dehydrogenase activity", "d": ["Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254291", "l": "ERBB4s80 binds STAT5A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706323", "l": "Active FLT3 binds to SLA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18072", "l": "L-arginine <=> D-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50390", "l": "5a,11a-dehydrooxytetracycline + H2O + NADP(+) => 5a,11a-dehydrotetracycline + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70392", "l": "3-oxosphinganine + eicosanoyl-CoA => CoA + H(+) + N-eicosanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31802", "l": "4-amino-5-aminomethyl-2-methylpyrimidine + H2O <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868236", "l": "BAR domain proteins recruit dynamin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43766", "l": "AMP + chenodeoxycholoyl-CoA + diphosphate => ATP + chenodeoxycholate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156930", "l": "GTP-binding activates eEF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48704", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 12S-HpEPE", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034838", "l": "menthone dehydrogenase activity", "d": ["Catalysis of the reaction: (-)-(2S,5R)-menthone + NAD+ = (5R)-menth-2-enone + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749977", "l": "UGT1A6 glucuronates ST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55662", "l": "2 A + echinenone + 3 H2O => 2 AH2 + all-trans-beta-carotene + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46645", "l": "cortisol + H(+) + NADPH => 5beta-dihydrocortisol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54185", "l": "an N-acyl-aromatic L-alpha-amino acid + H2O => a carboxylate + an aromatic L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708457", "l": "HM13 cleaves HMOX1 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46787", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42989", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => cembrene C + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59303", "l": "3'-phosphoadenylyl sulfate + firefly D-luciferin <=> adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047776", "l": "citramalate lyase activity", "d": ["Catalysis of the reaction: S-citramalate = acetate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0047617", "l": "acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48722", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH => aurachin B + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71980", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + fusoxypene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40221", "l": "CoA + H(+) + malonate => H2O + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168459", "l": "Lyn activates ERK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66115", "l": "2-oxobutanoate + L-tyrosine <=> (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11358", "l": "AH2 + NAD(+) => A + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209566", "l": "TRAF6 is auto-ubiquitinated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49969", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102640", "l": "paspalinine synthase activity", "d": ["Catalysis of the reaction: paspalicine + O2 + NADPH + H+ <=> paspalinine + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35844", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869580", "l": "DEK binds TFAP2A homodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48784", "l": "D-erythrulose 4-phosphate = D-erythrose 4-phosphate", "d": []}, {"i": "EC:5.3.1.34", "l": "\"D-erythrulose 4-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1454916", "l": "The ABCC family mediates organic anion transport (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202453", "l": "Auto-ubiquitination of TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52358", "l": "adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate => 3'-phosphoadenylyl sulfate + pregnenolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211224", "l": "Association of DFF40 with DFF45 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16151", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide => beta-nicotinamide D-ribonucleotide + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44129", "l": "(9E)-octadecenoyl-CoA + hexadecan-1-ol => CoA + hexadecanyl (9E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174438", "l": "Formation of the Flap Intermediate on the C-strand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60712", "l": "(+)-artemisinic alcohol + NAD(+) = (+)-artemisinic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9620456", "l": "sGC stimulators bind sGC:NO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5615668", "l": "AKR1C3 reduces atRAL to atROL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12793", "l": "1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63413", "l": "2,4,6-trichlorophenol + FADH2 + O2 => 2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408529", "l": "Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35129", "l": "L-alanyl-D-glutamate(in) => L-alanyl-D-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25617", "l": "terpentedienyl diphosphate = diphosphate + terpentetriene", "d": []}, {"i": "EC:4.2.3.36", "l": "\"terpentetriene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700154", "l": "Active ALK binds SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29015", "l": "phosphate(out) + sn-glycerol 3-phosphate(in) = phosphate(in) + sn-glycerol 3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54009", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017064", "l": "fatty acid amide hydrolase activity", "d": ["Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62685", "l": "norrubrofusarin + S-adenosyl-L-methionine => H(+) + rubrofusarin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44688", "l": "a 2-acylglycerol + H2O = a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806610", "l": "Keratin filament formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0043130", "l": "ubiquitin binding", "d": ["Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29033", "l": "L-glutamate(out) + 2 Na(+)(out) => L-glutamate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62847", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46238", "l": "a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727288", "l": "7a localizes to the ERGIC membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27887", "l": "2',3'-cyclophospho-AMP + H2O => 3'-AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73033", "l": "Cd(2+)(in) + H(+)(in) => Cd(2+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70508", "l": "dimethylallyl diphosphate + H2O => dimethylallyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9706837", "l": "AR binds AR antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757256", "l": "MCM3 binds MCM5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47697", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22011", "l": "L-homoserine + succinyl-CoA <=> CoA + O-succinyl-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211983", "l": "CYP2J2 oxidises ARA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32777", "l": "(2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate => (2-aminoethyl)phosphonate(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35417", "l": "an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP => an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44889", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64374", "l": "alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine => beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004984", "l": "olfactory receptor activity", "d": ["Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30661", "l": "4-hydroxy-L-threonine + phosphate => 4-(phosphooxy)-L-threonine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68824", "l": "(2E)-geranyl diphosphate = (Z)-beta-ocimene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70244", "l": "an N-acylsphing-4-enine + UDP-alpha-D-xylose => a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162657", "l": "Inactivation of Myt1 kinase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018761", "l": "bromoxynil nitrilase activity", "d": ["Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzonitrile + 2 H2O = 3,5-dibromo-4-hydroxybenzoate + NH4. Involved in the bacterial degradation of the herbicide bromoxynil."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0003934", "l": "GTP cyclohydrolase I activity", "d": ["Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35598", "l": "benzene-1,2,4-triol + O2 <=> 2 H(+) + maleylacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49885", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28195", "l": "(2S)-3-sulfolactate + NAD(+) => 3-sulfopyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649735", "l": "Intrinsic nucleotide exchange on RAS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74027", "l": "L-alanine(in) + L-threonine(out) = L-alanine(out) + L-threonine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28524", "l": "D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate => D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71406", "l": "2alpha-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70865", "l": "L-glutamine(in) + L-threonine(out) + Na(+)(in) => L-glutamine(out) + L-threonine(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.652932776586212", "identifiers": [{"i": "GO:0016408", "l": "C-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35207", "l": "H2O + IDP = H(+) + IMP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106310", "l": "protein serine kinase activity", "d": ["Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57720", "l": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate", "d": []}, {"i": "EC:7.1.2.2", "l": "\"H(+)-transporting two-sector ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429683", "l": "CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811508", "l": "ING2-bound EP300 acetylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195378", "l": "Homodimerization of VEGF proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007582", "l": "RAD51 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38730", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21263", "l": "[thioredoxin]-disulfide + H2O + L-methionine <=> [thioredoxin]-dithiol + L-methionine (R)-S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981713", "l": "C4b binds to cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362427", "l": "Hh-Np binds GPC5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26496", "l": "7-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41729", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77094", "l": "Formation of cap binding complex (CBC) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14089", "l": "2-oxoglutarate + glycine = glyoxylate + L-glutamate", "d": []}, {"i": "EC:2.6.1.4", "l": "\"glycine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030023", "l": "extracellular matrix constituent conferring elasticity", "d": ["A component of the extracellular matrix that enables the matrix to recoil after transient stretching."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9752980", "l": "RTP1S:RTP2:underrepresented Olfactory Receptor translocates from the endoplasmic reticulum membrane to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58024", "l": "oleanolate + UDP-alpha-D-glucose = H(+) + oleanolate 3-O-beta-D-glucoside + UDP", "d": []}, {"i": "EC:2.4.1.368", "l": "\"oleanolate 3-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41710", "l": "1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57424", "l": "guaiacol + O2 + reduced [NADH--hemoprotein reductase] = catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604763", "l": "Autocatalytic activation of MMP7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004957", "l": "prostaglandin E receptor activity", "d": ["Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013006", "l": "RHOA:GTP translocates to the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11281", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O => (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353434", "l": "Formation of Pol zeta complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044016", "l": "histone H3K4 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 4) = CoA + histone H3 N6-acetyl-L-lysine (position 4)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23080", "l": "L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O", "d": []}, {"i": "EC:4.2.1.90", "l": "\"L-rhamnonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57390", "l": "(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-178208", "l": "SMAD7 binds to SMURF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71217", "l": "2 Na(+)(in) + thiocyanate(in) => 2 Na(+)(out) + thiocyanate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35514", "l": "glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25608", "l": "2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O <=> 2-(3-methylsulfanyl)propylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35515", "l": "4'''-demalonylsalvianin + malonyl-CoA = CoA + salvianin", "d": []}, {"i": "EC:2.3.1.214", "l": "\"pelargonidin 3-O-(6-caffeoylglucoside) 5-O-(6-O-malonylglucoside) 4'''-malonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263490", "l": "Defective GALNS does not hydrolyse sulfate from Gal6S in keratan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22931", "l": "4-acetamidobutanoyl-CoA + H2O <=> 4-aminobutanoyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047301", "l": "valine-3-methyl-2-oxovalerate transaminase activity", "d": ["Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110215", "l": "Cleavage of uracil by UNG glycosylase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53839", "l": "a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine <=> a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56508", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912734", "l": "CBL:CRKL binds RAPGEF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19382", "l": "(S)-oxalosuccinate + H(+) => 2-oxoglutarate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912496", "l": "Formation of meiotic holliday junction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65868", "l": "Delta(1)-dihydrotestosterone + H2O = 1,17beta-dihydroxyandrostan-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33654", "l": "(9Z,12Z)-octadecadienoate + ATP + CoA <=> (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61785", "l": "L-allulose => keto-L-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.48", "l": "\"ruberlysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27463", "l": "diphosphate + GDP-D-glycero-alpha-D-manno-heptose => D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56501", "l": "(R)-3,5-bisphosphomevalonate + H(+) => CO2 + isopentenyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51683", "l": "(2E,6E)-farnesol + CTP <=> (2E,6E)-farnesyl phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68933", "l": "ATP + H(+) + NADPH + octanoate => AMP + diphosphate + NADP(+) + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20564", "l": "3-hydroxypyruvate + H(+) <=> CO2 + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40208", "l": "(2E)-tetradecenedioyl-CoA + H2O => (3S)-hydroxytetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809354", "l": "NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043008", "l": "ATP-dependent protein binding", "d": ["Binding to a protein or protein complex using energy from ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55055", "l": "H2O + pentanoyl-CoA <=> CoA + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59187", "l": "2,4-diacetylphloroglucinol + H2O <=> 2-acetylphloroglucinol + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9626914", "l": "α2-agonists bind ADRA2A,B,C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13795", "l": "2-methylene-3-methylsuccinate => 2-methyleneglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790987", "l": "NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050366", "l": "tyramine N-feruloyltransferase activity", "d": ["Catalysis of the reaction: feruloyl-CoA + tyramine = CoA + N-feruloyltyramine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176116", "l": "Recruitment and activation of Chk1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60415", "l": "H2O + monoglucosyl-enterobactin <=> [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47513", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isocholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381644", "l": "ER calcium channels open in response to activated PKA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.72", "l": "\"acetylxylan esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23211", "l": "acetyl-CoA + trans-glutaconate <=> (2E)-glutaconyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706298", "l": "Active FLT3 binds to CSK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55152", "l": "H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein] = (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.14", "l": "\"L-prolyl-[peptidyl-carrier protein] dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.40", "l": "\"phytepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65749", "l": "2-oxoglutarate + dodecyl sulfate + O2 => CO2 + dodecanal + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71694", "l": "glycyl-L-glutamate(out) + 2 H(+)(out) <=> glycyl-L-glutamate(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972948", "l": "POU5F1 (OCT4), SOX2, NANOG bind the GSC promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36831", "l": "2 caldariellaquinol + n H(+)(in) + O2 = 2 caldariellaquinone + n H(+)(out) + 2 H2O", "d": []}, {"i": "EC:7.1.1.4", "l": "\"caldariellaquinol oxidase (H(+)-transporting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51105", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30857", "l": "(S)-2,3-epoxysqualene + H2O => dammarenediol-II", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047925", "l": "geranoyl-CoA carboxylase activity", "d": ["Catalysis of the reaction: ATP + bicarbonate + geranoyl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212352", "l": "Formation of ARC coactivator complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204773", "l": "Interaction of Tie2 and Grb7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25122", "l": "(S)-2-amino-6-oxohexanoate => H(+) + H2O + L-1-piperideine-6-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59971", "l": "L-threonyl-[protein] + octanoyl-CoA <=> CoA + O-octanoyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18598", "l": "H(+) + NAD(+) + 2 reduced [rubredoxin] => NADH + 2 oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54320", "l": "a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0004725", "l": "protein tyrosine phosphatase activity", "d": ["Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445705", "l": "Release Of ADP From Myosin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016761", "l": "cellulose synthase (GDP-forming) activity", "d": ["Catalysis of the reaction: GDP-glucose + ((1,4)-beta-D-glucosyl)(n) = GDP + ((1,4)-beta-D-glucosyl)(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74735", "l": "S-adenosyl-L-methionine + syringetin = 7,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674385", "l": "p-T,Y MAPKs dimerize (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63984", "l": "5-hydroxyuridine + ATP = 5-hydroxyuridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16150", "l": "beta-nicotinamide D-ribonucleotide + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65875", "l": "1,17beta-dihydroxyandrostan-3-one + A <=> 17beta-hydroxyandrostan-1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33108", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + gamma-muurolene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.172", "l": "\"protein-ribulosamine 3-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.18", "l": "\"4-hydroxyphenylacetate 1-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53025", "l": "a plastoquinone + H2O + L-arginine => 5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928623", "l": "EPHBs bind NMDARs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64550", "l": "(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP] => N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683964", "l": "ATM phosphorylates EYA1-4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69115", "l": "glyoxylate + L-2-aminoadipate <=> 2-oxoadipate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9823816", "l": "OPTN binds CASP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935785", "l": "RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48319", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b <=> a ganglioside GD1alpha + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15784", "l": "L-tyrosine <=> 3-amino-3-(4-hydroxyphenyl)propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65532", "l": "2-methylbutan-1-ol + hexanoyl-CoA = 2-methylbutyl hexanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130706", "l": "MHC class II antigen processing (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788628", "l": "p-Y-STATs dissociate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047305", "l": "(R)-3-amino-2-methylpropionate-pyruvate transaminase activity", "d": ["Catalysis of the reaction: (2R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140806", "l": "SERPINC1 binds SERPINC1 activators (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176452", "l": "Degradation of ubiquitinated SMAD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65309", "l": "an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] => a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46989", "l": "(R)-6-hydroxynicotine + O2 => 6-hydroxy-N-methylmyosmine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75989", "l": "a dicarboxylate(out) + indoxyl sulfate(in) => a dicarboxylate(in) + indoxyl sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11315", "l": "atrazine + H2O <=> chloride + H(+) + hydroxyatrazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74966", "l": "L-leucine(out) + L-ornithine(in) + Na(+)(out) <=> L-leucine(in) + L-ornithine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71054", "l": "L-leucine(out) + L-methionine(in) <=> L-leucine(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53286", "l": "3-dehydro-scyllo-inosose + H(+) + NADH => NAD(+) + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004376", "l": "glycolipid mannosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28479", "l": "galactarate(in) + H(+)(in) => galactarate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12518", "l": "(+)-(R)-germacrene A + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56547", "l": "H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35143", "l": "benzoyl-CoA + 2 H(+) + 3 malonyl-CoA = 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA", "d": []}, {"i": "EC:2.3.1.220", "l": "\"2,4,6-trihydroxybenzophenone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22315", "l": "5-(methylsulfanyl)-D-ribose + ATP <=> ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74046", "l": "L-alanine(in) + L-methionine(out) <=> L-alanine(out) + L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23606", "l": "H2O + kievitone => kievitone hydrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.39", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20337", "l": "(R)-2-O-sulfolactate + H2O = (R)-lactate + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.17", "l": "\"D-lactate-2-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40505", "l": "N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018768", "l": "RHOU auto-activates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0050785", "l": "advanced glycation end-product receptor activity", "d": ["Combining with advanced glycation end-products and transmitting the signal to initiate a change in cell activity. Advanced glycation end-products (AGEs) form from a series of chemical reactions after an initial glycation event (a non-enzymatic reaction between reducing sugars and free amino groups of proteins)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36271", "l": "caffeine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141423", "l": "Binding of the MCC complex to the APC/C complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390593", "l": "ATP Hydrolysis By Myosin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112392", "l": "Resumption of elongation after recovery from pausing (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66079", "l": "2-oxopentanoate + L-kynurenine <=> H2O + kynurenate + L-2-aminopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16428", "l": "formaldehyde + H2O + NAD(+) <=> formate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69821", "l": "H2O + NADP(+) + taurine => H(+) + hypotaurine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.345", "l": "\"D-2-hydroxyacid dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54281", "l": "2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0070548", "l": "L-glutamine aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63882", "l": "cyanate + 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfur => 2 Fe(III)-[cytochrome c] + H2O + thiocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229132", "l": "AP4 binds APP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41773", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) => CMP + ganglioside GQ1b (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34142", "l": "Delta(9)-tetrahydrocannabinolate + H(+) <=> CO2 + Delta(9)-tetrahydrocannabinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29986", "l": "cytidine(in) + H(+)(in) <=> cytidine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43857", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54454", "l": "a uridine in tRNA + H(+) + NADH => a 5,6-dihydrouridine in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467794", "l": "Resolution of sister chromatids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73679", "l": "3'-AMP(in) + ADP(out) + H(+)(out) = 3'-AMP(out) + ADP(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53418", "l": "8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine => 8-amino-8-demethylriboflavin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879562", "l": "SLCO2B1 has a narrow substrate specificity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57006", "l": "CoA + H(+) + N(beta)-acetylstreptothricin D => acetyl-CoA + streptothricin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36655", "l": "desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine = descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.285", "l": "\"demethyldecarbamoylnovobiocin O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46065", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418856", "l": "Activation of Rac1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003911", "l": "DNA ligase (NAD+) activity", "d": ["Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928631", "l": "GIT1 binds bPIX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983147", "l": "Release of E3 from polyubiquitinated substrate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35941", "l": "diphosphate + tryprostatin B => brevianamide F + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909720", "l": "IFN alpha/beta binds to IFNAR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72038", "l": "ATP(out) + 2 H(+)(out) + phosphate(in) <=> ATP(in) + 2 H(+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20458", "l": "D-arabinose + NAD(+) => D-arabinono-1,4-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9718379", "l": "GNRHR binds chemical antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23341", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate => D-arabinose + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72120", "l": "(R)-carnitine(in) + glycine betaine(out) => (R)-carnitine(out) + glycine betaine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44778", "l": "H(+) + menaquinol-6 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-6 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50031", "l": "H2O + tetradecanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25200", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O <=> 5-amino-6-(D-ribitylamino)uracil + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45517", "l": "phycocyanobilin-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873921", "l": "Binding of STAT1 to p-IFNGR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29761", "l": "octanoate(out) => octanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201611", "l": "Caspase-mediated cleavage of Rock-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54916", "l": "9-cis-retinol + NADP(+) = 9-cis-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60275", "l": "N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003830", "l": "beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3282876", "l": "Defective G6PC3 does not hydrolyze glucose 6-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395340", "l": "Formation of hydroxyallysine by LOX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72877", "l": "anthocyanin A9 + CoA => anthocyanin A7 + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26561", "l": "(3S)-3-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166869", "l": "TRAF6 binds MEKK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59547", "l": "N,N'-diacetylchitobiose + O2 <=> H2O2 + N,N'-diacetylchitobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29017", "l": "phosphate(in) + sn-glycerol 3-phosphate(out) => phosphate(out) + sn-glycerol 3-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75184", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + lydicene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110463", "l": "Increased PIP3 levels recruit DAkt1 to the membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47722", "l": "NH4(+) + xanthine => H(+) + H2O + isoguanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0008320", "l": "protein transmembrane transporter activity", "d": ["Enables the transfer of a protein from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18394", "l": "(R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46505", "l": "dodecanoyl-AMP + holo-[ACP] => AMP + dodecanoyl-[ACP] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804099", "l": "HMGB1 binds LTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388811", "l": "CD28 homodimer binds B7-1 homodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29907", "l": "H2O + sn-glycero-3-phospho-(1'-rac-glycerol) = glycerol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54809", "l": "H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2 => H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33479", "l": "an acyl-CoA + lanosterol = CoA + lanosteryl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37312", "l": "ATP + glycyl-L-glutamine(out) + H2O => ADP + glycyl-L-glutamine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696491", "l": "CNTF binds CNTFR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13235", "l": "alpha-D-ribose 1-phosphate + guanine => guanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75699", "l": "2 glutathione + NAD(+) = glutathione disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.21", "l": "\"polo kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210292", "l": "Interaction of DAP12 and TREM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912415", "l": "NOTCH3 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982017", "l": "Active G alpha (q) binds RGS proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013004", "l": "RHOA binds effectors at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33951", "l": "ribostamycin + UDP-N-acetyl-alpha-D-glucosamine = 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.285", "l": "\"UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42556", "l": "uridine(2819) in 21S rRNA = pseudouridine(2819) in 21S rRNA", "d": []}, {"i": "EC:5.4.99.43", "l": "\"21S rRNA pseudouridine(2819) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-984671", "l": "Chromokinesins form dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371527", "l": "HSF1 trimer translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55713", "l": "(S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O => (9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14709", "l": "a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9006870", "l": "IL21 receptor STAT phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67153", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein] => L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40318", "l": "glutaryl-CoA + O2 <=> (2E)-glutaconyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12019", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-germacrene D + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14592", "l": "luteolin + S-adenosyl-L-methionine <=> chrysoeriol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40244", "l": "(3R)-hydroxyhexadecanoyl-CoA + NAD(+) => 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40370", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP <=> 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010276", "l": "phytol kinase activity", "d": ["Catalysis of the reaction: phytol + CTP = phytyl monophosphate + CDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432897", "l": "ILK interacts with beta-1 integrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2314686", "l": "ASA- acetylates PTGS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015568", "l": "L-idonate transmembrane transporter activity", "d": ["Enables the transfer of L-idonate from one side of a membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3321805", "l": "NSL acetylates histone H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70652", "l": "(9Z)-hexadecenoyl-[ACP] + L-lysyl-[protein] => H(+) + holo-[ACP] + N(6)-[(9Z)-hexadecenoyl]-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55010", "l": "(3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+) => (1R,4S)-1-hydroxylimonen-2-one + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14759", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate => 2 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27274", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336413", "l": "DT:HBEGF:CD9 is transported from clathrin-coated vesicle to endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10916", "l": "(1R,2R,3R)-prephytoene diphosphate = all-trans-phytoene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033450", "l": "GUC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GUC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.21", "l": "\"primary-amine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72103", "l": "Formation of pre-mRNPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854222", "l": "TBC1D3 associates with RAB5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16424", "l": "an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49875", "l": "(+)-dehydrodiconiferyl acid ketone + a quinone + H2O <=> (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60394", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) => Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209960", "l": "Diiodinated tyrosine can be deiodinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629679", "l": "PDE3A inhibitors bind PDE3A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68458", "l": "(2E)-glutaconyl-CoA + H2O => (S)-3-hydroxyglutaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008878", "l": "glucose-1-phosphate adenylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = ADP-glucose + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169406", "l": "ISGylation of host proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55651", "l": "2-oxoglutarate + O2 + validoxylamine A <=> CO2 + H(+) + succinate + validoxylamine B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014449", "l": "RHOG binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71124", "l": "(E)-caffeate + ATP + H(+) + 2 malonyl-CoA => AMP + 2 CO2 + 2 CoA + diphosphate + hispidin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052879", "l": "9,12-octadecadienoate 8-hydroperoxide 8S-isomerase activity", "d": ["Catalysis of the reaction: (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.17", "l": "\"nitric oxide dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429815", "l": "Formation Of Bloc-1 Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57496", "l": "2-methylcitrate = 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665989", "l": "DIAPH1 binds RHOA:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182986", "l": "CBL-mediated ubiquitination of CIN85 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047359", "l": "1-alkenyl-2-acylglycerol choline phosphotransferase activity", "d": ["Catalysis of the reaction: 1-alkenyl-2-acylglycerol + CDP-choline = plasmenylcholine + CMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56005", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39679", "l": "(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69053", "l": "RFC binding displaces Pol Alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56618", "l": "1,2,4-trichlorobenzene + chloride + H(+) => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41286", "l": "H2O + N-tetracosanoyl-sphing-4-enine <=> sphing-4-enine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111915", "l": "CAMK4 autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62675", "l": "a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine <=> an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37490", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine <=> 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26465", "l": "6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine <=> 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033225", "l": "ATPase-coupled 2-aminoethylphosphonate transporter activity", "d": ["Enables the directed movement of 2-aminoethylphosphonate from one side of a membrane to the other by catalysis of the reaction: ATP + H2O + 2-aminoethylphosphonate(out) = ADP + phosphate + 2-aminoethylphosphonate(in)."]}, {"i": "RHEA:32775", "l": "(2-aminoethyl)phosphonate(out) + ATP + H2O = (2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75604", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => plasmodiophorol A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669911", "l": "Phosphorylation of juxtamembrane domain KIT mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68708", "l": "(2E)-geranyl diphosphate + H2O = diphosphate + linalool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49811", "l": "a quinone + butan-1-ol <=> a quinol + butanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9010872", "l": "SLIT2 binds Dystroglycan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40053", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O => chorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43719", "l": "[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate <=> [glutamine synthetase]-L-tyrosine + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15148", "l": "D-maltose <=> alpha,alpha-trehalose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73112", "l": "S-adenosyl-L-methionine + scutellarein 4'-methyl ether => ladanein + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40468", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36306", "l": "a fatty acyl-CoA + 2 H(+) + 2 NADPH <=> a long-chain primary fatty alcohol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13585", "l": "ATP + butanoate = ADP + butanoyl phosphate", "d": []}, {"i": "EC:2.7.2.7", "l": "\"butyrate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781840", "l": "ERCC6 binds stalled RNA Pol II (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15119", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine => 3'-dephospho-CoA + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798474", "l": "S100A8:S100A9 binds Zn2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71185", "l": "L-kynurenine(in) + L-tryptophan(out) => L-kynurenine(out) + L-tryptophan(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39409", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75008", "l": "H(+)(out) + VO(2+)(out) => H(+)(in) + VO(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22593", "l": "(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate => (9S,13S,15Z)-12-oxophyto-10-15-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863472", "l": "DAB2 binds LRP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54671", "l": "pre-alpha-onocerin <=> alpha-onocerin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53413", "l": "(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 => (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395992", "l": "p-T,4S-IRF3 is dimerized (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57586", "l": "a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a flavanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61163", "l": "quercetin + UDP-beta-L-rhamnose <=> H(+) + quercitrin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432164", "l": "Ca2+ influx into the post-synaptic cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35845", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54213", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 => 2-(prostaglandin G2)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944262", "l": "Association of procollagen type X (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654409", "l": "Activated FGFR3 binds FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909729", "l": "Activation of JAK kinases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666008", "l": "SCAI binds SRF:MKL1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47546", "l": "cis-4-hydroxy-D-proline betaine => trans-4-hydroxy-L-proline betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111264", "l": "Addition of nucleotides between position +11 and +30 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33966", "l": "ATP + isopentenyl phosphate <=> ADP + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63472", "l": "all-trans-hexaprenol + ATP = ADP + all-trans-hexaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13847", "l": "2-hydroxy-3-oxopropanoate + CO2 => dihydroxyfumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44714", "l": "a 1-acylglycerol + a fatty acid + H(+) => a 1,2-diacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26158", "l": "D-glucosone + H(+) + NADPH => D-mannose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376126", "l": "DSCAM binds Netrin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964284", "l": "BTK in active Gq-BTK complex is activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45202", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+) => (6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685208", "l": "CCDC59:TTF1 binds SFTPB gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39149", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66804", "l": "ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029471", "l": "Hydrolysis of PC to PA by PLD (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0019840", "l": "isoprenoid binding", "d": ["Binding to an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62967", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose <=> alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0141050", "l": "histone H3K deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine + H2O = histone H3 L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51552", "l": "D-sorbitol + NADP(+) = H(+) + L-xylo-3-hexulose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35624", "l": "D-glutamate + D-glutamine => gamma-D-glutamyl-D-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809309", "l": "MTMR6 binds MTMR9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093331", "l": "Ras:GTP binds p120-RasGAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013145", "l": "RAC1 binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61466", "l": "a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389762", "l": "Phosphorylation of PD-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58485", "l": "H2O + N-(acetyl)-sphing-4-enine => acetate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57876", "l": "uridine(54) in tRNA = pseudouridine(54) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40558", "l": "dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 <=> dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0051765", "l": "inositol tetrakisphosphate kinase activity", "d": ["Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42486", "l": "D-sorbitol 6-phosphate(in) + L-histidyl-[protein] => D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50809", "l": "glutathione + prostaglandin J2 => prostaglandin J2-S-(S)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014812", "l": "ROBOs bind keratan sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10392", "l": "(E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38105", "l": "2-dehydro-3-deoxy-L-galactonate + H2O => L-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111879", "l": "PIP2 hydrolysis (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17727", "l": "2-methyl-cis-aconitate + H2O => (2S,3S)-2-methylcitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2545203", "l": "Deacetylation of cleaved cohesin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853793", "l": "p-5Y-RET complexes bind GRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55086", "l": "(3R)-3-hydroxypentanoate + CoA + H(+) => (3R)-3-hydroxypentanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610726", "l": "The IFT-A complex recruits TULP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58525", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH => (16S)-deshydroxymethyl-stemmadenine + formate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38823", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50392", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + oxytetracycline = 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10259", "l": "[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O <=> [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63869", "l": "(9Z)-octadecenoate + O2 => (2R,9Z)-2-hydroperoxyoctadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354073", "l": "Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0034338", "l": "short-chain carboxylesterase activity", "d": ["Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40691", "l": "1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol = 1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44017", "l": "2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) => 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70301", "l": "2,3-dioxo-L-gulonate => H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49182", "l": "a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine => a bacteriochlorophyllide d + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707516", "l": "FeHM dissociates from MetHb (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70553", "l": "3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-threonyl-[EGF-like domain protein] + H(+) + UDP => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382053", "l": "Translocation of PDGF from ER to Golgi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033432", "l": "CGG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CGG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3857336", "l": "CEBPB homodimerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41555", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O <=> diphosphate + ophiobolin F", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018719", "l": "6-aminohexanoate transaminase activity", "d": ["Catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51649", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + O2 => (S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0015049", "l": "methane monooxygenase activity", "d": ["Catalysis of the reaction: methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47713", "l": "trans-3-hydroxy-L-proline => cis-3-hydroxy-D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350901", "l": "Iodide is organified (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10989", "l": "H2O + nitrous oxide => 2 e(-) + 2 H(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34722", "l": "15-methylhexadecasphing-4-enine 1-phosphate <=> (2E)-13-methyltetradecenal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52570", "l": "epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP => epitestosterone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047033", "l": "15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + prostaglandin I(2) = 15-dehydro-prostaglandin I(2) + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25787", "l": "2-dehydro-3-deoxy-L-rhamnonate <=> (S)-lactaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22491", "l": "S-(hydroxymethyl)glutathione <=> formaldehyde + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109701", "l": "PDPK1 binds PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43558", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12281", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47258", "l": "6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35981", "l": "diphosphate + fumitremorgin A => dimethylallyl diphosphate + verruculogen", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39709", "l": "a long-chain fatty acyl-CoA(in) => a long-chain fatty acyl-CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134800", "l": "STING dimerization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55563", "l": "a hydroperoxyeicosatetraenoate <=> a hydroxy-epoxy-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40012", "l": "(+)-copalyl diphosphate + H2O => diphosphate + manool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10484", "l": "H2O + N-feruloylglycine = (E)-ferulate + glycine", "d": []}, {"i": "EC:3.5.1.71", "l": "\"N-feruloylglycine deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56229", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine => (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2545196", "l": "FN1 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49462", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+) => (2Z,4E)-2-aminomuconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46476", "l": "4alpha-hydroxymethylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formylzymosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66398", "l": "ADP + cholate(out) + glutathione(out) + H(+) + phosphate => ATP + cholate(in) + glutathione(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56215", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391156", "l": "Phosphorylation of ITIM motif in SIRP alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51669", "l": "2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031405", "l": "lipoic acid binding", "d": ["Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623168", "l": "FOXO1,FOXO1:PPARGC1A,FOXO3,FOXO4,FOXO6 bind G6PC gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38982", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57336", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18012", "l": "glutaryl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64962", "l": "dTMP + H(+) + phosphate => dTDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73577", "l": "CAD hexamer transforms L-Gln to CAP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55933", "l": "3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O => AMP + H(+) + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044323", "l": "retinoic acid-responsive element binding", "d": ["Binding to a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68124", "l": "a 1,2-diacylglycerol + a fatty acyl-[ACP] = a triacylglycerol + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38841", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51691", "l": "galactitol + NAD(+) <=> H(+) + keto-L-tagatose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74742", "l": "Phosphorylation of SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111264", "l": "Addition of nucleotides between position +11 and +30 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66103", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine <=> H2O + kynurenate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23006", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP => a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11367", "l": "ATP + H2O + pyruvate <=> AMP + 2 H(+) + phosphate + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388829", "l": "SHP2 phosphatase binds CTLA-4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671737", "l": "p-T774-PKN1 binds CDC25C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50848", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16534", "l": "L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60524", "l": "5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351871", "l": "Caspase-mediated cleavage of Z0-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191786", "l": "snRNP complex assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68193", "l": "decanoyl-CoA + phytol => CoA + decanoate phytyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15832", "l": "a 16alpha-hydroxysteroid <=> a 16beta-hydroxysteroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189488", "l": "UROS transforms HMB to URO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52893", "l": "H2O + NADP(+) + nitrosobenzene => H(+) + NADPH + nitrobenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730882", "l": "Phosphorylation of PKC-theta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444572", "l": "Zinc is an agonist of GPR39 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018721", "l": "trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity", "d": ["Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-9,10-dihydrodiolsulfate conjugate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432034", "l": "Aquaporin-6 passively transports anions into vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12348", "l": "(S)-muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate", "d": []}, {"i": "EC:5.3.3.4", "l": "\"muconolactone Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322431", "l": "XIAP binds TLE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025033", "l": "NTF3 binds NTRK2 (TRKB) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43162", "l": "H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine => adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30227", "l": "dimethyl sulfide + 2 Fe(III)-[cytochrome c2] + H2O = dimethyl sulfoxide + 2 Fe(II)-[cytochrome c2] + 2 H(+)", "d": []}, {"i": "EC:1.8.2.4", "l": "\"dimethyl sulfide:cytochrome c2 reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016828", "l": "hydrolase activity, acting on acid sulfur-sulfur bonds", "d": ["Catalysis of the hydrolysis of any acid sulfur-sulfur bond."]}, {"i": "EC:3.12.-.-", "l": "\"Acting on sulfur-sulfur bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42800", "l": "15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) = all-trans-4,4'-diaponeurosporene + 3 FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101020", "l": "estrogen 16-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: estrogen + donor-H2 + O2 = 16-alpha-hydroxyestrogen + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663194", "l": "Some pathogenic BRCA1 mutants do not bind BARD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19541", "l": "L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH", "d": []}, {"i": "EC:1.2.1.41", "l": "\"glutamate-5-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12521", "l": "L-dopa => (E)-caffeate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11274", "l": "a 2-oxocarboxylate + a quinol => a (2R)-2-hydroxycarboxylate + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430096", "l": "GP1b-IX-V binds filamin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71585", "l": "L-histidine(out) + Na(+)(out) => L-histidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27829", "l": "hydrogen sulfide + O-succinyl-L-homoserine <=> L-homocysteine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10452", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase] = (R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25252", "l": "H(+) + 2 pyruvate <=> (2S)-2-acetolactate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35739", "l": "cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] = 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone", "d": []}, {"i": "EC:1.14.15.6", "l": "\"cholesterol monooxygenase (side-chain-cleaving)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15882", "l": "ATP + L-seryl-[Fas-activated protein] => ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193656", "l": "p75NTR interacts with RIP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807826", "l": "LDHAL6B reduces PYR to LACT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202717", "l": "Heterodimerization of CEACAMs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35693", "l": "1'-hydroxyversicolorone + H(+) + NADPH => (2S)-versicolorone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5362522", "l": "ALDHs oxidise atRAL to atRA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800315", "l": "MST1 binds MST1R (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41680", "l": "a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) = a 2-all-trans-polyprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429441", "l": "SYK activation by SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76093", "l": "(11R)-19-oxocarlactone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (11R)-19-hydroxycarlactone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71838", "l": "estrone 3-sulfate(out) <=> estrone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42421", "l": "2-oxoglutarate + L-lysine + O2 => (4R)-4-hydroxy-L-lysine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56717", "l": "H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] => H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41137", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+) => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33365", "l": "D-mannitol 1-phosphate(in) + L-histidyl-[protein] => D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045031", "l": "G protein-coupled ATP receptor activity", "d": ["Combining with ATP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74039", "l": "D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391150", "l": "p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112435", "l": "Formation of Elongin BC complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13910", "l": "phosphate + urate D-ribonucleoside => alpha-D-ribose 1-phosphate + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015655", "l": "alanine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alanine(out) + Na+(out) = alanine(in) + Na+(in)."]}, {"i": "RHEA:29283", "l": "L-alanine(in) + Na(+)(in) = L-alanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14644", "l": "cyanurate + H2O <=> biuret + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018785", "l": "RHOBTB2 binds GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4647594", "l": "SAHF formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420243", "l": "GHRH receptor binds GHRH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62199", "l": "2 Fe(III)-[cytochrome c] + propan-2-ol <=> acetone + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59275", "l": "L-cysteine <=> D-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45663", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.53", "l": "\"lytic chitin monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58571", "l": "15alpha-stemmadenine + acetyl-CoA <=> CoA + O-acetyl-15alpha-stemmadenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.n1", "l": "\"blood group B branched chain alpha-1,3-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45846", "l": "3-oxooctanoyl-CoA + H(+) + NADPH => (3R)-hydroxyoctanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26045", "l": "CoA + N-acetyl-9-O-acetylneuraminate => acetyl-CoA + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76386", "l": "CYP1A2 S-demethylates 6MMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047155", "l": "3-hydroxymethylcephem carbamoyltransferase activity", "d": ["Catalysis of the reaction: a 3-hydroxymethylceph-3-em-4-carboxylate + carbamoyl-phosphate = phosphate + a 3-carbamoyloxymethylcephem."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942224", "l": "Filaggrin binds Keratin tonofilament:Desmosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243938", "l": "AKT1 E17K mutant is phosphorylated by TORC2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877620", "l": "ECE2 cleaves EDN1(53-90) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243942", "l": "PDPK1 phosphorylates AKT1 E17K mutant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30865", "l": "L-tyrosine + phosphate => 4-O-phospho-L-tyrosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29259", "l": "(2R,3R)-tartrate(out) + succinate(in) = (2R,3R)-tartrate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62200", "l": "ethanol + 2 Fe(III)-[cytochrome c] = acetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56225", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38900", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51566", "l": "(25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0001847", "l": "opsonin receptor activity", "d": ["Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49123", "l": "H(+) + NADPH + O2 + protoviolaceinate <=> H2O + NADP(+) + violaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793958", "l": "Expression of STAT6-upregulated plasma membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198669", "l": "p38MAPK phosphorylates MSK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39615", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA = (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097677", "l": "STAT family protein binding", "d": ["Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22013", "l": "precorrin-4 + S-adenosyl-L-methionine => precorrin-5 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632412", "l": "PTK2 is recruited to methylated ESR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693589", "l": "SARS-CoV-1 dsRNA intermediates bind DDX58 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42320", "l": "a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11635", "l": "AH2 + L-selenocysteine <=> A + H(+) + hydrogenselenide + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031782", "l": "type 4 melanocortin receptor binding", "d": ["Binding to a type 4 melanocortin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990738", "l": "pseudouridine 5'-phosphatase activity", "d": ["Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44454", "l": "3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10399", "l": "an L-alpha-amino acid + H2O + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449077", "l": "Interleukin-16 is secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28912", "l": "H(+)(out) + L-lysine(out) => H(+)(in) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373741", "l": "SDK2 homophillic interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043431", "l": "2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39707", "l": "a long-chain fatty acyl-CoA(out) = a long-chain fatty acyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61954", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13445", "l": "(R)-pantetheine + H2O = (R)-pantothenate + cysteamine", "d": []}, {"i": "EC:3.5.1.92", "l": "\"pantetheine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55761", "l": "a fatty acyl-[ACP] + a lyso-ornithine lipid => an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806974", "l": "MET dimers autophosphorylate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193653", "l": "NGF homodimer binds to p75NTR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2106614", "l": "Duplex miRNA is loaded into Argonaute (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0033677", "l": "DNA/RNA helicase activity", "d": ["Unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045462", "l": "trichothecene 3-O-acetyltransferase activity", "d": ["Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022818", "l": "sodium ion uniporter activity", "d": ["Catalysis of the active transport of a sodium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48044", "l": "ganglioside GM1 (d18:1(4E)/18:0) + H2O = D-galactose + ganglioside GM2 (d18:1(4E)/18:0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20982", "l": "2 biliverdin IXalpha + 2 H2O => 2 bilirubin IXalpha + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005047", "l": "signal recognition particle binding", "d": ["Binding to a signal recognition particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33216", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate => all-trans-heptaprenyl diphosphate + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43274", "l": "ganglioside GD2 + H(+) + UDP => ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65988", "l": "previtamin D3 = calciol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31373", "l": "(2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine => (2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56027", "l": "H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70741", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10344", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": []}, {"i": "EC:2.3.1.25", "l": "\"plasmalogen synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36471", "l": "3,4,5-trihydroxybenzoate(out) + H(+)(out) = 3,4,5-trihydroxybenzoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62982", "l": "(9Z)-hexadecenoate + NH4(+) => (9Z)-hexadecenamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74437", "l": "a 1-acyl-sn-glycero-3-phosphocholine(in) + H(+)(in) => a 1-acyl-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102960", "l": "momilactone-A synthase activity", "d": ["Catalysis of the reaction: 3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide + NAD(P) = momilactone A + H+ + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088305", "l": "FOXM1 stimulates PLK1 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70573", "l": "argininosuccinate <=> fumarate + arginine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11058", "l": "4-aminophenol + CO2 + H2O + NADP(+) => 4-aminobenzoate + 2 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48510", "l": "3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH => cholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42197", "l": "(9Z)-heptadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-heptadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64095", "l": "3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 <=> 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31541", "l": "(2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine => (2S)-naringenin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61185", "l": "quercitrin + UDP-beta-L-rhamnose => H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423656", "l": "AFXBO hydrolyses non-enzymatically to AFBDHD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9754129", "l": "CDK6 inhibitors bind CDK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34274", "l": "2-nitroimidazole + H2O <=> 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75999", "l": "glutarate(in) + kynurenate(out) = glutarate(out) + kynurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73673", "l": "ADP(in) + diphosphate(out) => ADP(out) + diphosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855190", "l": "I(1,4,5)P3 transports from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73852", "l": "27-hydroxywithanone + UDP-alpha-D-glucose => H(+) + UDP + withanone 27-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18473", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP", "d": []}, {"i": "EC:2.4.2.17", "l": "\"ATP phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32568", "l": "(2E)-geranyl diphosphate => (1R,4S)-camphene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192781", "l": "Viral mRNA Splicing (M, NS segments) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-555065", "l": "Formation of clathrin coated vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24596", "l": "acetyl-CoA + L-histidine = CoA + H(+) + N(alpha)-acetyl-L-histidine", "d": []}, {"i": "EC:2.3.1.33", "l": "\"histidine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212222", "l": "PRC2 recruits DNA methyltransferases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933532", "l": "Processing of caspases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26385", "l": "all-trans-8'-apo-beta-carotenal + O2 = (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal", "d": []}, {"i": "EC:1.13.11.75", "l": "\"all-trans-8'-apo-beta-carotenal 15,15'-oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70344", "l": "chloride + L-tyrosine + NADP(+) => 3-chloro-L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40875", "l": "(9Z,12Z)-octadecadienoyl-CoA + FAD + H(+) = (2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950426", "l": "Expression of lymphocyte cytosolic protein 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69626", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42302", "l": "a 1-acyl-sn-glycero-3-phosphate + holo-[ACP] => a fatty acyl-[ACP] + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69401", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68534", "l": "(Z)-alpha-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609741", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2D (GRIN2D) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53368", "l": "5,6-dihydrouridine(17) in tRNA + NADP(+) = H(+) + NADPH + uridine(17) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70978", "l": "3-sulfino-L-alanine(out) + L-aspartate(in) <=> 3-sulfino-L-alanine(in) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0046592", "l": "polyamine oxidase activity", "d": ["Catalysis of the oxidative degradation or interconversion of polyamines."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72384", "l": "Na(+)(out) + urate(in) => Na(+)(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62055", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47540", "l": "7-oxolithocholate + H(+) + NADPH = NADP(+) + ursodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.48", "l": "\"plasminogen activator Pla\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48946", "l": "3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48144", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine = ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26455", "l": "NADP(+) + propanoyl-CoA => acryloyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56337", "l": "ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75218", "l": "beta-L-fucose + NADP(+) <=> H(+) + L-fucono-1,5-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4331340", "l": "TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58269", "l": "[protein]-C-terminal glycine + NAD(+) => [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760641", "l": "HOXC8 binds CDH11 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220967", "l": "p-NICD1 PEST domain mutants do not bind FBXW7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75541", "l": "(2E)-decenoyl-[ACP] + AMP + diphosphate => (2E)-decenoate + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621370", "l": "SYK autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691131", "l": "CANDI binds CUL1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008684", "l": "TBK1 phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54978", "l": "(3S)-hydroxytetradecanoate + CoA + H(+) => (3S)-hydroxytetradecanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61830", "l": "H(+) + stigmasteryl 3-beta-D-glucoside + UDP => stigmasterol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033972", "l": "proclavaminate amidinohydrolase activity", "d": ["Catalysis of the reaction: amidinoproclavaminate + H2O = proclavaminate + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64120", "l": "an N-(fatty acyl)-L-serine + H2O = a fatty acid + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983421", "l": "Journey of cargo through Golgi complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69866", "l": "a uridine in mRNA + S-adenosyl-L-methionine <=> a 5-methyluridine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39082", "l": "(3S)-hydroxydodecanedioyl-CoA + NAD(+) <=> 3-oxododecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47658", "l": "CoA + H(+) + N-acetyl-L-methionine sulfone => acetyl-CoA + L-methionine sulfone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164840", "l": "ADP and Pi bind to ATPase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61919", "l": "ATP + fluconazole(in) + H2O <=> ADP + fluconazole(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74868", "l": "(E)-caffeyl aldehyde + CoA + NADP(+) => (E)-caffeoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31630", "l": "10-deoxymethynolide + dTDP-alpha-D-desosamine <=> 10-deoxymethymycin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68393", "l": "H2O + peracetic acid => acetate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44033", "l": "9,10-epoxy-(12Z)-octadecenoate + H2O => 9,10-dihydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139895", "l": "tBID activates BAK protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37974", "l": "H(+) + NADPH + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32262", "l": "beta-D-fructose 1-phosphate + methylglyoxal <=> 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11571", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP <=> 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69850", "l": "a 5,6-dihydrouridine in RNA + NADP(+) <=> a uridine in RNA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0099529", "l": "neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential", "d": ["Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047914", "l": "gamma-glutamylhistamine synthase activity", "d": ["Catalysis of the reaction: histamine + L-glutamate + ATP = N(alpha)-gamma-L-glutamylhistamine + products of ATP breakdown."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14425", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.68", "l": "\"1-phosphatidylinositol-4-phosphate 5-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23337", "l": "2 H(+) + H2O2 + 2 iodide => diiodine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797712", "l": "CDK12 stimulates expression of DNA repair genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72373", "l": "dehydroepiandrosterone 3-sulfate(in) + succinate(out) => dehydroepiandrosterone 3-sulfate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22588", "l": "4-aminobutanal = 1-pyrroline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37310", "l": "glycyl-L-asparagine + H2O <=> glycine + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17053", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate", "d": []}, {"i": "EC:2.2.1.2", "l": "\"transaldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047678", "l": "arginine 2-monooxygenase activity", "d": ["Catalysis of the reaction: L-arginine + O2 = 4-guanidinobutanamide + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799350", "l": "Exocytosis of specific granule membrane proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9676160", "l": "AAMP binds NOD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46574", "l": "5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10893", "l": "(2R,3S)-3-isopropylmalate + NAD(+) => (2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69152", "l": "Removal of remaining Flap (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019948", "l": "SUMO activating enzyme activity", "d": ["Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70393", "l": "CoA + H(+) + N-eicosanoyl-3-oxosphinganine => 3-oxosphinganine + eicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51208", "l": "20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28045", "l": "CoA + NAD(+) + pyruvate <=> acetyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75689", "l": "ATP(out) => ATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40556", "l": "dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 => dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9761421", "l": "CDH11 associates with catenins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40049", "l": "1,2-dioctanoyl-sn-glycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8862380", "l": "HSD17B13 binds lipid droplets (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350598", "l": "Arginine<=>Agmatine+CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603548", "l": "NTRK3(496-641) binds NELFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40533", "l": "H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75849", "l": "9-cis-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9-cis-retinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38234", "l": "(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA <=> 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31669", "l": "dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781897", "l": "USP11 deubiquitinates NFKBIA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43681", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15208", "l": "a dolichyl diphosphooligosaccharide + H2O <=> a dolichyl phosphate + an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68603", "l": "ORC5 binds ORC2:ORC3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65099", "l": "a 2-acylglycerol + hexadecanoyl-CoA <=> a 1-hexadecanoyl-2-acylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161293", "l": "Tropoelastin forms aggregate globules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947535", "l": "Cyclisation of GTP to precursor Z (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015211", "l": "purine nucleoside transmembrane transporter activity", "d": ["Enables the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32718", "l": "(2R,3S)-3-methylmalate + NAD(+) <=> 2-oxobutanoate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37159", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37334", "l": "H2O + L-methionyl-L-alanine <=> L-alanine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047788", "l": "2-coumarate reductase activity", "d": ["Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NAD+ = trans-2-coumarate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73526", "l": "TTP(out) + UTP(in) <=> TTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110153", "l": "RNA NAD-cap (NMN-forming) hydrolase activity", "d": ["Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H+."]}, {"i": "RHEA:60876", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10052", "l": "(R)-2-hydroxy-4-methylpentanoate + NAD(+) = 4-methyl-2-oxopentanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047421", "l": "N-acyl-D-glutamate deacylase activity", "d": ["Catalysis of the reaction: N-acyl-D-glutamate + H2O = D-glutamate + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664940", "l": "PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866277", "l": "AP-2 directly binds some endocytic cargo (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50425", "l": "(8Z,11Z,14Z)-eicosatrienoate + 2 O2 => prostaglandin G1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51522", "l": "(S)-tembetarine + H(+) + S-adenosyl-L-homocysteine => (S)-reticuline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48002", "l": "H2O2 + NADP(+) => 1,6-dihydro-beta-NADP + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62087", "l": "ADP + D-glucosamine <=> AMP + D-glucosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47180", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) = (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047956", "l": "glycerol dehydrogenase [NADP+] activity", "d": ["Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.14", "l": "\"cytosol alanyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007901", "l": "IL1F10 binds IL1RL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64031", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine <=> H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112604", "l": "Phosphorylated STATs are released (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15145", "l": "D-maltose = alpha,alpha-trehalose", "d": []}, {"i": "EC:5.4.99.16", "l": "\"maltose alpha-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67617", "l": "8-oxo-GTP + H2O => 8-oxo-GMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446372", "l": "Association of  PARVA with TESK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56281", "l": "3'-L-prolyl-AMP + holo-[peptidyl-carrier protein] => AMP + L-prolyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69668", "l": "H2O + luteolin 4'-O-beta-D-glucoside => beta-D-glucose + luteolin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564179", "l": "Collagen type XI degradation by MMP1,2,3,9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66346", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44950", "l": "1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+) => 1-O-alkyl-2,3-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73471", "l": "D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.10", "l": "\"ABC-type D-xylose transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22618", "l": "2 (2R)-bisdechlorogeodin + 2 H2O => 2 H(+) + O2 + 2 sulochrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848774", "l": "PTK6 binds DOK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27520", "l": "phosphate + sphing-4-enine => H2O + sphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27845", "l": "9H-carbazole + H(+) + NADPH + O2 <=> 2'-aminobiphenyl-2,3-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001565", "l": "phorbol ester receptor activity", "d": ["Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42184", "l": "5alpha-androstane-3beta,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72515", "l": "(R)-carnitine(out) + glutarate(in) = (R)-carnitine(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685290", "l": "SFTPD gene produces SFTPD protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052835", "l": "inositol-3,4,6-trisphosphate 1-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H+."]}, {"i": "REACT:R-HSA-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20193", "l": "(R)-mevalonate + NADP(+) = H(+) + mevaldate + NADPH", "d": []}, {"i": "EC:1.1.1.33", "l": "\"mevaldate reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32397", "l": "(1S,4S)-dihydrocarvone + H(+) + NADH => (1S,2S,4S)-dihydrocarveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69492", "l": "O2 + octan-1-ol = H2O2 + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202453", "l": "Auto-ubiquitination of TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534359", "l": "CatSper Channel Mediated Calcium Transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004113", "l": "2',3'-cyclic-nucleotide 3'-phosphodiesterase activity", "d": ["Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67754", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63351", "l": "ATP + L-amino acyl-L-cysteinyl-[protein] <=> (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65288", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912727", "l": "CBL binds VAV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67446", "l": "a long-chain fatty aldehyde + formyl-CoA => an (R)-2-hydroxy-long-chain-fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16208", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] <=> N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76039", "l": "(S)-cis-N-methyltetrahydrothalifendine + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxy-8-methoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.0(4,9).0(16,20)]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24639", "l": "H2 + NAD(+) <=> H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873794", "l": "PCTP binds PC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41227", "l": "(S)-4-hydroxymandelate + O2 = 4-hydroxyphenylglyoxylate + H2O2", "d": []}, {"i": "EC:1.1.3.46", "l": "\"4-hydroxymandelate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56368", "l": "3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 = 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032840", "l": "intramolecular proline-rich ligand binding", "d": ["Binding to a proline-rich region within the same polypeptide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102514", "l": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose <=> cyanidin 3,7-di-O-beta-D-glucoside betaine + ferulate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76059", "l": "heliamine + S-adenosyl-L-methionine = H(+) + N-methylheliamine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72103", "l": "Formation of pre-mRNPs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48930", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide => CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170159", "l": "Translocation of Cdc25 to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.50", "l": "\"bothrolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69074", "l": "Formation of Processive Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36057", "l": "a 2,4-dihydroxypteridine + NH4(+) => a 2-amino-4-hydroxypteridine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54232", "l": "1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21741", "l": "2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol => [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63448", "l": "(2-aminoethyl)phosphonate + CTP = CMP-(2-aminoethyl)phosphonate + diphosphate", "d": []}, {"i": "EC:2.7.7.107", "l": "\"(2-aminoethyl)phosphonate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617832", "l": "FOXO4:ATXN3 binds SOD2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672176", "l": "STAT binds to the mutant PDGFRA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48780", "l": "ATP + L-erythrulose = ADP + H(+) + L-erythrulose 1-phosphate", "d": []}, {"i": "EC:2.7.1.209", "l": "\"L-erythrulose 1-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60517", "l": "L-tryptophan => D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33280", "l": "L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2859050", "l": "Hydrolysis of C4b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74390", "l": "formamide(out) <=> formamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52502", "l": "(13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008715", "l": "CDP-diacylglycerol diphosphatase activity", "d": ["Catalysis of the reaction: CDP-diacylglycerol + H2O = a phosphatidate + CMP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74976", "l": "a (3R)-3-isocyanyl-fatty acyl-AMP + holo-[ACP] => a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31631", "l": "2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate = phosphate + pseudaminate", "d": []}, {"i": "EC:2.5.1.97", "l": "\"pseudaminic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675194", "l": "Activated MAPK phosphorylates RAF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018639", "l": "xylene monooxygenase activity", "d": ["Catalysis of the reactions: toluene + 1/2 O2 = benzyl alcohol, and xylene + 1/2 O2 = methylbenzyl alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26294", "l": "(1'S,5'S)-averufin + NADPH + O2 => 1'-hydroxyversicolorone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49110", "l": "3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine => Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20476", "l": "(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55581", "l": "ATP + H2O + L-glutamine => AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23225", "l": "trans-zeatin + UDP-alpha-D-glucose => H(+) + O-beta-D-glucosyl-trans-zeatin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40193", "l": "3-oxooctanoyl-CoA + H(+) + NADH => (3R)-hydroxyoctanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51831", "l": "ATP(in) + CoA(in) + docosanoate(out) + H(+)(out) <=> AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174446", "l": "Removal of remaining Flap from the C-strand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48380", "l": "alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55437", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168886", "l": "Hemopexin binds Hemes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19925", "l": "D-ribitol 5-phosphate + NAD(+) = D-ribulose 5-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10331", "l": "an L-glycol + NAD(+) <=> a 2-hydroxycarbonyl + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71667", "l": "malonate(out) + succinate(in) = malonate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74748", "l": "myricetin + S-adenosyl-L-methionine => 3-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70837", "l": "L-arginine(out) + L-glutamine(in) + Na(+)(in) => L-arginine(in) + L-glutamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372697", "l": "Crk binding to p130cas (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24320", "l": "an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035133", "l": "NR1H2,3 binds the CETP gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2250301", "l": "Formation of lysyl-pyrrole cross-links (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29857", "l": "D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate => H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404133", "l": "A REH hydrolses atREs to atROL and FAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36426", "l": "2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47116", "l": "eicosanoate + glycine = H2O + N-eicosanoylglycinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3229181", "l": "CALM1:Ca2+ binds CNG channel (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68615", "l": "Formation of ORC(1-6) complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797100", "l": "CCNK binds CDK13 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58126", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde => (19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10744", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) = 3,4-dihydroxybenzoate + CO2 + NADH", "d": []}, {"i": "EC:1.3.1.53", "l": "\"(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48351", "l": "a uridine in RNA <=> a pseudouridine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-593685", "l": "Netrin-4 binds DCC/UNC5A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5250930", "l": "B-WICH recruits histone acetyltransferases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672164", "l": "GRB2:SOS1 complex binds to mutant PDGFR receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9615348", "l": "AGT(34-41) binds to AGTR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43163", "l": "adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3204311", "l": "AOX1 oxidises PXL to PDXate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50434", "l": "A + H2O + prostaglandin H1 => AH2 + prostaglandin G1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102438", "l": "laricitrin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: laricitrin(1-) + S-adenosyl-L-methionine <=> H+ + 3',4'-dimethylmyricetin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71534", "l": "guanine(out) <=> guanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130194", "l": "ABL phosphorylates WAVEs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.46", "l": "\"pyrimidine monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605723", "l": "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71979", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + fusoxypene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215406", "l": "PRMT5 binds WDR77 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67940", "l": "2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35510", "l": "30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66565", "l": "histamine + L-glutaminyl-[protein] => 5-histaminyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56512", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706837", "l": "AR binds AR antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140761", "l": "sequestered tissue factor -> tissue factor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781897", "l": "USP11 deubiquitinates NFKBIA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32837", "l": "4-(trimethylamino)butanoate(out) => 4-(trimethylamino)butanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871265", "l": "YAP1 binds TEAD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70253", "l": "cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine => beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0036137", "l": "kynurenine aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from kynurenine to an acceptor, usually a 2-oxo acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49252", "l": "D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] = D-fructose 1-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.202", "l": "\"protein-N(pi)-phosphohistidine--D-fructose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53012", "l": "2,5-dichlorohydroquinone + 2 glutathione = chloride + chlorohydroquinone + glutathione disulfide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448962", "l": "Heterodimerization of E proteins with Myod (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201669", "l": "Beta-catenin translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21620", "l": "FMNH2 + NAD(+) = FMN + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610954", "l": "HCMV Final Envelopment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196026", "l": "Dab2 is recruited to the junctional plaques (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16584", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2 <=> 2 Fe(III)-[cytochrome c] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21283", "l": "H2O + 2 O2 + thiamine <=> H(+) + 2 H2O2 + thiamine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001064", "l": "cellooligosaccharide binding", "d": ["Binding to cellooligosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183055", "l": "Binding of CBL to EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748996", "l": "GST dimers cleave AZA to 6MP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68098", "l": "a 3'-end ribonucleotide-RNA + a 5'-end (5'-phospho)-ribonucleoside-RNA + H(+) => a ribonucleotidyl-ribonucleotide-RNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875568", "l": "RAPGEF1 activates RAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69954", "l": "3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydroteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20139", "l": "baccatin III + CoA => 10-deacetylbaccatin III + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18902", "l": "H(+) + H2O + N-benzyloxycarbonyl-L-leucine => benzyl alcohol + CO2 + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63075", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + orcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.136", "l": "\"glucuronoarabinoxylan endo-1,4-beta-xylanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41400", "l": "1-hexanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0016695", "l": "oxidoreductase activity, acting on hydrogen as donor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor."]}, {"i": "EC:1.12.-.-", "l": "\"Acting on hydrogen as donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730903", "l": "Oligomerization of TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2032781", "l": "WWTR1 (TAZ) binds TEAD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70474", "l": "2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in single-stranded DNA + H2O + O2 <=> a 2'-deoxycytidine in single-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036729", "l": "Defective GAA does not hydrolyze lysosomal glycogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450466", "l": "AUF1:mRNA complex is destroyed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11819", "l": "alpha-D-glucose 6-phosphate <=> beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15286", "l": "AMP + dimethylallyl diphosphate => diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874078", "l": "PTK2 autophosphorylates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848873", "l": "PTK6 phosphorylates ARAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52302", "l": "(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1031713", "l": "GAF binds the GAS promoter elements in the IFNG-regulated genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27594", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 5 diphosphate", "d": []}, {"i": "EC:2.5.1.85", "l": "\"all-trans-nonaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932400", "l": "MYC:MAX binds the CDC25A gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730483", "l": "SARS-CoV-2 nsp16 binds to U1 snRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606602", "l": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578777", "l": "DMPK phosphorylates PLN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29102", "l": "a menaquinone + 5 H(+)(in) + NADH <=> a menaquinol + 4 H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.8", "l": "\"ribonuclease M5\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75253", "l": "3'-dehydrocarminate + H2O2 => carminate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70602", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46501", "l": "2-oxoglutarate + O2 + UMP => CO2 + phosphate + succinate + uridine-5'-aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209196", "l": "Phosphorylation of CI by PKA-C1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52058", "l": "12-hydroxyoctadecanoate + H(+) + hexadecanoate => 12-hexadecanoyloxy-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70395", "l": "3-oxosphinganine + docosanoyl-CoA = CoA + H(+) + N-docosanoyl-3-ketodihydrosphingosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705926", "l": "AR binds AR agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110311", "l": "POLZ extends translesion synthesis (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692749", "l": "CDC14A,B bind MAPK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218814", "l": "PAK2 autophorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23172", "l": "ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] = ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]", "d": []}, {"i": "EC:2.7.11.31", "l": "\"[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13563", "l": "(S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+) => H2O + meso-2,6-diaminoheptanedioate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46458", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) => 5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17573", "l": "demethylmacrocin + S-adenosyl-L-methionine = H(+) + macrocin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.102", "l": "\"demethylmacrocin O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9656947", "l": "OGG1beta translocates to mitochondria (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67381", "l": "H2O + L-alanyl-L-cysteine => L-alanine + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14336", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol <=> 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43783", "l": "2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43672", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12408", "l": "L-lysine + NAD(+) = 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34282", "l": "di-trans,poly-cis-dolichol + NADP(+) <=> di-trans,cis-polyprenol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41803", "l": "acetyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47720", "l": "H(+) + H2O + isoguanine = NH4(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55071", "l": "a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60104", "l": "H(+) + indole-3-propanoate + oxidized [electron-transfer flavoprotein] = (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50815", "l": "androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782943", "l": "UV-DDB ubiquitinates XPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71597", "l": "2-oxoglutarate(in) + succinate(out) => 2-oxoglutarate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050627", "l": "mycothione reductase activity", "d": ["Catalysis of the reaction: NAD(P)+ + mycothiol = NAD(P)H + H+ + mycothione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26536", "l": "3-hydroxypropanoyl-CoA + AMP + diphosphate => 3-hydroxypropanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693250", "l": "RHOD binds effectors at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9716913", "l": "ESR1 binds ESR1 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199910", "l": "MSK1 activates ATF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44078", "l": "AMP + diphosphate + pentadecanoyl-CoA => ATP + CoA + pentadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418553", "l": "cAMP degradation by Phosphodiesterases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35149", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out) => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388560", "l": "EDNRA,EDNRB bind EDNs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75929", "l": "cyclohexanone + H(+) + NADH + NH4(+) => cyclohexylamine + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57717", "l": "hydrogencarbonate + NH4(+) => carbamate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374909", "l": "Metabolism of Noradrenaline (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36227", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.22", "l": "\"1-alkenyl-2-acylglycerol choline phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62042", "l": "N-octanoylsphing-4-enine + phosphate => H2O + N-(octanoyl)-sphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45111", "l": "(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] <=> 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70044", "l": "6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16485", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate = 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate", "d": []}, {"i": "EC:6.3.4.8", "l": "\"imidazoleacetate--phosphoribosyldiphosphate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433415", "l": "Activation of RAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43385", "l": "ATP + L-arginyl-[protein] => ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18416", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189069", "l": "sucrose + H2O => glucose + fructose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254251", "l": "ERBB4s80 binds YAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989752", "l": "Expression of TXNRD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35228", "l": "H(+)(out) + rifampicin(in) => H(+)(in) + rifampicin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9716947", "l": "ESR1 binds ESR1 agonists (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011748", "l": "IL9R binds JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452108", "l": "Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34305", "l": "L-pipecolate + NH4(+) => L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14800", "l": "2-dehydro-3-deoxy-D-gluconate + ATP <=> 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40531", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757540", "l": "PREDN,PREDL diffuse into GI cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23291", "l": "acetaldehyde + CoA + NAD(+) <=> acetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69039", "l": "5beta-androstane-3,17-dione + H(+) + NADPH <=> 3beta-hydroxy-5beta-androstane-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17648", "l": "H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] <=> N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30510", "l": "2-demethylmenaquinone-8 + H(+) + NADH <=> 2-demethylmenaquinol-8 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50199", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043837", "l": "valine dehydrogenase (NAD) activity", "d": ["Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.80", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72987", "l": "myo-inositol(out) + 2 Na(+)(out) = myo-inositol(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381612", "l": "GLP1R binds GLP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49742", "l": "CO2 + deoxyviolacein + 2 H2O + NADP(+) => 2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173631", "l": "Activation of C1s (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205262", "l": "Direct recruitment of PI3K to p-KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21462", "l": "2 benzaldehyde => benzoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23571", "l": "(2E)-decenoyl-[ACP] <=> (3Z)-decenoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55536", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose = a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.892466024748572", "identifiers": [{"i": "GO:0015295", "l": "solute:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70570", "l": "H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67438", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29548", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine => 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75907", "l": "ADP-L-glycero-beta-D-manno-heptose + L-seryl-[protein] = ADP + H(+) + O-(L-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10077", "l": "H2O + lactose => beta-D-galactose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65692", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine = a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42196", "l": "(9Z)-heptadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-heptadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931981", "l": "RUNX1 binds ESR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70536", "l": "GDP-beta-L-fucose + L-seryl-[EGF-like domain protein] => 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483174", "l": "PE is methylated to PC by PEMT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46483", "l": "4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730903", "l": "Oligomerization of TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27867", "l": "(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O => (R)-glycerate + alpha-D-mannose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62564", "l": "(4S)-limonene + A + H2O = (4S)-perillyl alcohol + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60578", "l": "Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[tetramethylammonium-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31988", "l": "(S)-2,3-epoxysqualene => baruol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102639", "l": "paspalicine synthase activity", "d": ["Catalysis of the reaction: 13-desoxypaxilline + NADPH + O2 + H+ <=> paspalicine + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420206", "l": "Phosphorylation of SRC-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9620103", "l": "ALDH2 transforms GTN to NO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24080", "l": "ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)", "d": []}, {"i": "EC:6.1.1.2", "l": "\"tryptophan--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21513", "l": "3,6-anhydro-L-galactonate => 2-dehydro-3-deoxy-L-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61458", "l": "(1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+) => 7-chlorotetracycline + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65420", "l": "GMP(in) + NAD(+)(out) = GMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163310", "l": "TFAM binds to mitochondrial promoters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36732", "l": "1-nitrocyclohexan + NADP(+) => 1-nitrocyclohexene + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029473", "l": "Branching and elongation of mother and daughter filaments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6813749", "l": "ALDH1A1 oxidises GA to DGA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32843", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol = a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11269", "l": "D-cysteine + H2O => H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47824", "l": "H(+) + malonyl-[ACP] + octadecanoyl-[ACP] = 3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102913", "l": "3-aminomethylindole N-methyltransferase activity", "d": ["Catalysis of the reaction: indol-3-ylmethylamine + S-adenosyl-L-methionine = H+ + N-methyl-3-aminomethylindole + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37255", "l": "A + D-asparagine + H2O = 2-oxosuccinamate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199587", "l": "KIR2DS1 interacting with HLA-C group 2 (Cw4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32759", "l": "L-lysine = (3R)-3-methyl-D-ornithine", "d": []}, {"i": "EC:5.4.99.58", "l": "\"methylornithine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.86", "l": "\"ADAM 17 endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65056", "l": "glycochenodeoxycholate + NADP(+) = 7-oxoglycolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202291", "l": "Activation of Lck (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32788", "l": "ATP + H2O + L-ectoine(out) => ADP + H(+) + L-ectoine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.27", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047893", "l": "flavonol 3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018648", "l": "methanesulfonate monooxygenase activity", "d": ["Catalysis of the reaction: methanesulfonate + NADH + H+ + O2 = formaldehyde + NAD+ + sulfite + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74319", "l": "O-acetyl-(R)-carnitine(in) = O-acetyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33059", "l": "(R)-dihydrolipoamide + NAD(+) = (R)-lipoamide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341048", "l": "SUMOylation of RXRA with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-376419", "l": "Formation of NR-MED1 Coactivator Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34416", "l": "(1R,4R)-bornane-2,5-dione + FMNH2 + O2 => (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52722", "l": "5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+) => 5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-525833", "l": "NCAM1 interacts with T- and L-type VDCC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264615", "l": "Loading of acetylcholine in synaptic vesicles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191072", "l": "Synthesis of Cx43 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34462", "l": "8-hydroxycopalyl diphosphate + H2O <=> diphosphate + sclareol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68585", "l": "ATP + H2O + L-tryptophan(out) => ADP + H(+) + L-tryptophan(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375157", "l": "Interaction of NCAM1 with contactin-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70176", "l": "beta-D-glucosyl-(1->4)-D-galactose + phosphate => alpha-D-glucose 1-phosphate + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429714", "l": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27960", "l": "cytosine + D-ribose => cytidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33988", "l": "(+)-copalyl diphosphate => diphosphate + neoabietadiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18762", "l": "a 1,2-diacyl-sn-glycerol + H2O => a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31652", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O => 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015148", "l": "D-xylose transmembrane transporter activity", "d": ["Enables the transfer of D-xylose from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68047", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417927", "l": "P2Y2 receptor binds ATP and UTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65653", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine => a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10343", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-vetispiradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62385", "l": "cyclic (2R)-2,3-bisphosphoglycerate + H2O => (2R)-2,3-bisphosphoglycerate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047351", "l": "GTP guanylyltransferase activity", "d": ["Catalysis of the reaction: 2 GTP + H+ = P(1),P(4)-bis(5'-guanosyl) tetraphosphate + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34571", "l": "C30 botryococcene + diphosphate + NADP(+) = H(+) + NADPH + presqualene diphosphate", "d": []}, {"i": "EC:1.3.1.97", "l": "\"botryococcene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22981", "l": "a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] => a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48309", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O => (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25938", "l": "8-methylquinolin-2(1H)-one + AH2 => 8-methylquinoline + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57521", "l": "15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654159", "l": "Activated FGFR2 binds PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55022", "l": "5,6-diaminouracil + D-ribose 5-phosphate => 5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030184", "l": "nitric oxide transmembrane transporter activity", "d": ["Enables the transfer of nitric oxide, nitrogen monoxide, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983158", "l": "Trimming of peptides in ER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008964", "l": "phosphoenolpyruvate carboxylase activity", "d": ["Catalysis of the reaction: phosphate + oxaloacetate = phosphoenolpyruvate + HCO3-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44548", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22511", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) <=> diphosphate + DNA(n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17230", "l": "acetyl-CoA + an aliphatic alcohol => an acetyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43919", "l": "(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31590", "l": "FMNH2 + NADH + O2 + uracil <=> (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.8.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989778", "l": "Expression of ACSL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139895", "l": "tBID activates BAK protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419644", "l": "Transphosphorylation of pLIMK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047715", "l": "hypotaurocyamine kinase activity", "d": ["Catalysis of the reaction: ATP + hypotaurocyamine = N(omega)-phosphohypotaurocyamine + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814374", "l": "Kazrin binds periplakin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1470009", "l": "Phosphorylation of STATs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190829", "l": "Lysosomal degradation of gap junction plaques (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71542", "l": "H(+)(out) + 2 nitrate(out) <=> H(+)(in) + 2 nitrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16522", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0008392", "l": "arachidonic acid epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid."]}, {"i": "REACT:R-HSA-211983", "l": "CYP2J2 oxidises ARA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607002", "l": "Activated protein C cleaves factor VIIIa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052639", "l": "salicylic acid glucosyltransferase (ester-forming) activity", "d": ["Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid glucose ester + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42365", "l": "2 a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65770", "l": "a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76082", "l": "a dicarboxylate(in) + L-sepiapterin(out) <=> a dicarboxylate(out) + L-sepiapterin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64465", "l": "L-tyrosyl-[protein] + 2 O2 => H(+) + H2O2 + L-topaquinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74726", "l": "Dissociation of insulin from insulin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2995388", "l": "PP2A dephosphorylates BANF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16891", "l": "6-acetamido-3-oxohexanoate + L-glutamate => 2-oxoglutarate + 6-acetamido-3-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082356", "l": "HSF1-mediated gene expression (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12499", "l": "2 Fe(2+) + 4 H2O + O2 <=> 6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38910", "l": "(R)-reticuline + S-adenosyl-L-methionine <=> (R)-laudanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74747", "l": "myricetin + S-adenosyl-L-methionine = 3-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250220", "l": "Homodimerization of ERBB4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.207", "l": "\"mannosyl-oligosaccharide alpha-1,3-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799350", "l": "Exocytosis of specific granule membrane proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36464", "l": "glycyl-L-glutamate + H2O => glycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14100", "l": "3-phenylpyruvate + L-aspartate <=> L-phenylalanine + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29919", "l": "alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP = ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45909", "l": "chloroorienticin B + dTDP-beta-L-vancosamine => chloroeremomycin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449117", "l": "TXLNA (IL14) binds syntaxin1A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39119", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 = (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65867", "l": "5alpha-androst-1-ene-3,17-dione + A + H2O <=> 5alpha-androstan-1,3,17-trione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13918", "l": "(-)-menthol + NADP(+) => (1R,4S)-menthone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49066", "l": "calcitetrol + H2O + 2 oxidized [adrenodoxin] => 2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47301", "l": "(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73815", "l": "O2 + piceatannol = 3,4-dihydroxybenzaldehyde + 3,5-dihydroxybenzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12085", "l": "D-mannitol + NAD(+) => D-fructose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68869", "l": "ATP + benzoate + H(+) + NADPH => AMP + benzaldehyde + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66570", "l": "preluffariellolide A => (2E,6E,10E,14E)-geranylfarnesol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68538", "l": "(-)-alpha-cedrene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010859", "l": "calcium-dependent cysteine-type endopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67626", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033769", "l": "glyceollin synthase activity", "d": ["Catalysis of the reactions: 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin II or glyceollin III + NADP+ + 2 H2O, and 4-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin I + NADP+ + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205286", "l": "GRB2:SOS interacts with p-KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69179", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] <=> 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9015111", "l": "Factor Xa inhibitors binds Xa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381466", "l": "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696275", "l": "RND2 binds GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67232", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA + NAD(+) = (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2984226", "l": "PLK1 phosphorylates NEK9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050646", "l": "5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding", "d": ["Binding to 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17136", "l": "ATP + L-seryl-[tyrosine-3-monooxygenase] <=> ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29508", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-gurjunene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43200", "l": "cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.226", "l": "\"23S rRNA (cytidine(1920)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854290", "l": "TBC1D20 binds NS5A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62017", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose => 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-445079", "l": "Phosphorylation of L1 by ERK (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73286", "l": "H(+)(out) + L-isoleucine(in) <=> H(+)(in) + L-isoleucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0017110", "l": "nucleoside diphosphate phosphatase activity", "d": ["Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18662", "l": "H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) => H(+) + L-ornithine + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51418", "l": "an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2S,3R)-flavan-3-ol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65184", "l": "2-oxoglutarate + O2 + preaustinoid A1 = berkeleyone B + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65675", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687465", "l": "MRN complex binds RBBP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.52", "l": "\"peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140684", "l": "histone H3K9me2/H3K9me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37154", "l": "(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate <=> 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878056", "l": "RUNX1:CBFB binds EP300 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218814", "l": "PAK2 autophorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202222", "l": "Phosphorylation of PKC theta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24353", "l": "ethyl (R)-3-hydroxyhexanoate + NADP(+) => ethyl 3-oxohexanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61290", "l": "5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+) => 5-deoxy-D-ribose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.20", "l": "\"Delta(7)-sterol 5(6)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005142", "l": "interleukin-11 receptor binding", "d": ["Binding to an interleukin-11 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33466", "l": "episterol + H(+) + NADPH + O2 <=> 5-dehydroepisterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015016", "l": "[heparan sulfate]-glucosamine N-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876993", "l": "CBLL1 binds SRC-phosphorylated CDH1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134901", "l": "LRR FLII-interacting protein 1 associates with beta-catenin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636669", "l": "esxA binds ENO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68695", "l": "3'-phosphoadenylyl sulfate + 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(beta-D-glucuronate) <=> 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51265", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] => (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851866", "l": "MET binds RANBP10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67684", "l": "a long-chain fatty acid(in) + ATP + H2O = a long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25044", "l": "H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate <=> L-selenocysteinyl-tRNA(Sec) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65224", "l": "(1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+) = H(+) + NADPH + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11772", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.220", "l": "\"6-pyruvoyltetrahydropterin 2'-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23707", "l": "GTP + 4 H2O <=> 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55178", "l": "2-hydroxybutanoyl-CoA + CO2 + succinate => 2-oxoglutarate + butanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044547", "l": "DNA topoisomerase binding", "d": ["Binding to a DNA topoisomerase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41887", "l": "dodecanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10112", "l": "L-homocysteine + L-serine = H2O + L,L-cystathionine", "d": []}, {"i": "EC:4.2.1.22", "l": "\"cystathionine beta-synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1297354", "l": "Acrosin Cleavage (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66055", "l": "indole-3-pyruvate + L-kynurenine <=> H2O + kynurenate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52227", "l": "3 AH2 + 3 H(+) + heme b + 3 O2 <=> 3 A + biliverdin delta + CO + Fe(2+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:1990814", "l": "DNA/DNA annealing activity", "d": ["An activity that faciliates the formation of a complementary double-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58008", "l": "(20S)-ginsenoside F1 + UDP-alpha-D-glucose = (20S)-ginsenoside Rg1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804100", "l": "HMGB1 binds LPS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63879", "l": "2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2 <=> (4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37548", "l": "D-glucose 6-phosphate + NAD(+) => 3-dehydro-D-glucose 6-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202534", "l": "Ubiquitination of NEMO by TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13977", "l": "D-serine = NH4(+) + pyruvate", "d": []}, {"i": "EC:4.3.1.18", "l": "\"D-serine ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13591", "l": "3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate => 3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51866", "l": "8-geranylesculetin + diphosphate => (2E)-geranyl diphosphate + esculetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74582", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein] <=> N-acetyl-L-cysteine + N-terminal L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69815", "l": "cathasterone + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050782", "l": "galactose uniporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose (out) = galactose(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174203", "l": "SCF-mediated degradation of Emi1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22649", "l": "holo-[cytochrome c] => apo-[cytochrome c] + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49253", "l": "D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] => D-fructose 1-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0017169", "l": "CDP-alcohol phosphatidyltransferase activity", "d": ["Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193669", "l": "TRAF6 binds to p75NTR:NRIF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981353", "l": "RASA1 stimulates RAS GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805285", "l": "PLK3 phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112755", "l": "SOCS3 binds IL6ST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004114", "l": "3',5'-cyclic-nucleotide phosphodiesterase activity", "d": ["Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646354", "l": "PolyUb-Misfolded Proteins:HDAC6 dissociate from complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654399", "l": "Activated FGFR2 binds FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35786", "l": "neamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin B + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982637", "l": "Opsins binds G alpha-t (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53731", "l": "H2O + N-acetyl-D-muramate 6-phosphate <=> N-acetyl-D-muramate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2514865", "l": "cGMP dissociates from CNG channels (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55508", "l": "cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.71", "l": "\"cucurbitadienol 11-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390438", "l": "FAR2 reduces PalmCoA to HXOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665408", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33646", "l": "(9Z)-tetradecenoate + ATP + CoA <=> (9Z)-tetradecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191656", "l": "Closure of gap junction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177930", "l": "GAB1 phosphorylation by EGFR kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34802", "l": "2,3-didehydroadipoyl-CoA + acetyl-CoA <=> 3-oxo-5,6-didehydrosuberyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174070", "l": "Association of Cdh1 with the APC/C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043810", "l": "ornithine-acyl [acyl carrier protein] N-acyltransferase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein]. The enzyme, found in bacteria, catalyzes the first step in the biosynthesis of ornithine lipids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44769", "l": "3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) => 2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68801", "l": "H2O + nigerose => alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102484", "l": "esculetin glucosyltransferase activity", "d": ["Catalysis of the reaction: esculetin + UDP-alpha-D-glucose(2-) <=> esculin + UDP(3-) + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50752", "l": "2 naphthalene-1,2,4,8-tetrol + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.5", "l": "\"beta-aspartyl-peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696958", "l": "USP44 deubiquitinates CDC20 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793451", "l": "MLKL binds ITCH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59540", "l": "(2R)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43159", "l": "guanosine(9) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34578", "l": "2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3782655", "l": "HDAC10 deacetylates histone (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336182", "l": "GPR37 binds prosaptide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654167", "l": "Activated FGFR1 binds PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38497", "l": "a 1,3-diacylglycerol + a fatty acid + H(+) => a triacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63175", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA <=> (25R)-3-oxocholest-4-en-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111930", "l": "Adenylate cyclase produces cAMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1297333", "l": "Association of Acrosin Heavy and Light Chain (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700156", "l": "Active ALK dimer binds IRS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45002", "l": "CoA + O-3-hydroxybutanoyl-(R)-carnitine => (R)-carnitine + 3-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733330", "l": "CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22826", "l": "2-deoxy-alpha-D-ribose 1-phosphate + uracil => 2'-deoxyuridine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005000", "l": "vasopressin receptor activity", "d": ["Combining with vasopressin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37695", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA = 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54702", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+) => 4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036127", "l": "3-sulfino-L-alanine binding", "d": ["Binding to 3-sulfino-L-alanine (cysteine sulfinate)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.72", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31829", "l": "(+)-gamma-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420265", "l": "AMY1-3 bind IAPP(34-70) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51712", "l": "keto-D-tagatose 6-phosphate = keto-D-fructose 6-phosphate", "d": []}, {"i": "EC:5.1.3.40", "l": "\"D-tagatose 6-phosphate 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0005384", "l": "manganese ion transmembrane transporter activity", "d": ["Enables the transfer of manganese (Mn) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46130", "l": "4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033954", "l": "alpha-neoagaro-oligosaccharide hydrolase activity", "d": ["Catalysis of the hydrolysis of the 1,3-alpha-L-galactosidic linkages of neoagaro-oligosaccharides that are smaller than a hexamer, yielding 3,6-anhydro-L-galactose and D-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28816", "l": "4-hydroxybenzoate(in) + H(+)(out) => 4-hydroxybenzoate(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15261", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33882", "l": "2-deoxy-scyllo-inosamine + NADP(+) <=> 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013110", "l": "RHOC binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380930", "l": "Phosphorylated AMPK binds AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32192", "l": "H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47318", "l": "(2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37446", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173542", "l": "SMURF2 ubiquitinates SMAD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667914", "l": "ALK binds ligand midkine (MDK) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418662", "l": "Src activation following P2Y purinoceptor activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12724", "l": "putrescine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + S-methyl-5'-thioadenosine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50204", "l": "(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611852", "l": "ADRB3 bind ADR,NAd (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867041", "l": "EGFR phosphorylates EPS15 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57421", "l": "NADH + 2 oxidized [cytochrome P450] => H(+) + NAD(+) + 2 reduced [cytochrome P450]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18808", "l": "[DsbA protein]-disulfide + [protein]-dithiol <=> [DsbA protein]-dithiol + [protein]-disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69139", "l": "2 H2O + 2 O2 + spermine <=> 2 H2O2 + 2 NH4(+) + spermine dialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19731", "l": "acetone + CO2 => acetoacetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45512", "l": "phycocyanobilin-L-cysteinyl(155)-[C-phycocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[C-phycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15827", "l": "AZD1979 oxetane hydrolysis product + H(+) => AZD1979 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27796", "l": "all-trans-heptaprenyl diphosphate + 4 diphosphate => (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66429", "l": "D-arabinose(out) + H(+)(out) => D-arabinose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050216", "l": "propanediol-phosphate dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + propane-1,2-diol 1-phosphate = H+ + hydroxyacetone phosphate + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.222", "l": "\"2-polyprenyl-6-hydroxyphenol methylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70459", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2 = a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605535", "l": "Expression of SIRT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42513", "l": "5-acetamidopentanoate + H2O => 5-aminopentanoate + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003963", "l": "RNA-3'-phosphate cyclase activity", "d": ["Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450494", "l": "HuR binds mRNAs in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102361", "l": "esculetin 4-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: esculetin + UDP-alpha-D-glucose <=> 4-O-beta-D-glucosyl-esculetin + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36713", "l": "ADP + CO2 + D-cycloserine + NH4(+) + phosphate => ATP + H(+) + H2O + O-ureido-D-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351901", "l": "Caspase-mediated cleavage of MST3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200879", "l": "Formation of a Nef:ARF1:CD4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937134", "l": "miR-27a binds RUNX1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51925", "l": "AH2 + menaquinone-9 => A + beta-dihydromenaquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52109", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA => 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72871", "l": "anthocyanin A3 + malonyl-CoA = anthocyanin A5 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13989", "l": "alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose", "d": []}, {"i": "EC:2.7.7.12", "l": "\"UDP-glucose--hexose-1-phosphate uridylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16344", "l": "(R)-5-phosphomevalonate + ATP <=> (R)-5-diphosphomevalonate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46924", "l": "(R)-2-hydroxy-4-methylpentanoyl-CoA = 4-methylpent-2-enoyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.157", "l": "\"(R)-2-hydroxyisocaproyl-CoA dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51148", "l": "a primary alcohol + 2 oxidized [azurin] = an aldehyde + 2 H(+) + 2 reduced [azurin]", "d": []}, {"i": "EC:1.1.9.1", "l": "\"alcohol dehydrogenase (azurin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448728", "l": "IL19 binds IL20RA:JAK1:IL20RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41510", "l": "H2O + N(5)-hydroxy-L-ornithine + NADP(+) => L-ornithine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60478", "l": "3',3',3'-cAAG + 3 diphosphate => 2 ATP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14415", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) => biphenyl-2,3-diol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50748", "l": "H2O + juglone = naphthalene-1,2,4,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031820", "l": "P2Y11 nucleotide receptor binding", "d": ["Binding to a P2Y11 nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21523", "l": "2 Fe(III)-[cytochrome b1] + formate <=> CO2 + 2 Fe(II)-[cytochrome b1] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008906", "l": "inosine kinase activity", "d": ["Catalysis of the reaction: ATP + inosine = ADP + IMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376122", "l": "DSCAM/DSCAML1 homodimerization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46535", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67105", "l": "2-oxoglutarate + fumigatonoid C + O2 => CO2 + H2O + novofumigatonin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0047154", "l": "methylmalonyl-CoA carboxytransferase activity", "d": ["Catalysis of the reaction: pyruvate + D-methylmalonyl-CoA = oxaloacetic acid + propionyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66049", "l": "2-oxobutanoate + L-kynurenine => (2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070338", "l": "5'-flap-structured DNA binding", "d": ["Binding to a 5'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 5'-end of DNA or RNA protrudes from a double-stranded DNA molecule. 5'-flap structures can be formed during DNA repair or lagging strand synthesis; in the latter case RNA flaps form from lagging strand RNA primers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70399", "l": "3-oxosphinganine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57383", "l": "(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66940", "l": "acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine = 12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69374", "l": "2-oxohexanoate + H2O2 => 2-hydroxyhexanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26423", "l": "3'-phosphoadenylyl sulfate + thyroxine => adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805061", "l": "CK2 binds FACT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676596", "l": "TRAF3 binds BAFFR:BAFF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45711", "l": "3-dehydrocarnitine + acetyl-CoA <=> 3-dehydrocarnityl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9754974", "l": "ADK phosphorylates RBV (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58944", "l": "6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH = 7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+)", "d": []}, {"i": "EC:2.3.1.290", "l": "\"spectinabilin polyketide synthase system\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12006", "l": "H(+) + indican + UDP => indoxyl + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58215", "l": "ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] <=> dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004379", "l": "glycylpeptide N-tetradecanoyltransferase activity", "d": ["Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32402", "l": "(1S,2R,4S)-neodihydrocarveol + NAD(+) <=> (1S,4S)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64801", "l": "NAD(+) + S-(2-aminoethyl)-L-cysteine => (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72059", "l": "glycochenodeoxycholate(out) + 2 Na(+)(out) = glycochenodeoxycholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51905", "l": "10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate => 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.120", "l": "\"oligoxyloglucan beta-glycosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199583", "l": "KIR2DS2 interacting with HLA-C group 1 (Cw3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31304", "l": "a reduced flavin + NAD(+) => an oxidized flavin + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193646", "l": "NGF binding to p75NTR inactivates RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201669", "l": "Beta-catenin translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683964", "l": "ATM phosphorylates EYA1-4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61918", "l": "ADP + fluconazole(out) + H(+) + phosphate => ATP + fluconazole(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749505", "l": "LRRC14 binds IKBKB and CHUK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046180", "l": "KSPG is secreted from the cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004025", "l": "alcohol dehydrogenase activity, iron-dependent", "d": ["Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25135", "l": "phosphate + pyridoxamine = H2O + pyridoxamine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162657", "l": "Inactivation of Myt1 kinase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36401", "l": "H(+) + NADPH + zymosterol => 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876868", "l": "ECE1 cleaves EDN1(53-90) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59307", "l": "3'-phosphoadenylyl sulfate + firefly L-luciferin <=> adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952419", "l": "SMURFs ubiquitinate RUNX3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22151", "l": "a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] <=> a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.93", "l": "\"tartrate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43508", "l": "2,5-diformylfuran + H2O = 2-(dihydroxymethyl)-5-formylfuran", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848316", "l": "IL36 binds IL1RL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76091", "l": "(11R)-19-hydroxycarlactone + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-19-oxocarlactone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46268", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17869", "l": "5,6,7,8-tetrahydropteridine + NAD(+) = 6,7-dihydropteridine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59645", "l": "D-xylobiono-1,5-lactone + H2O => D-xylobionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72695", "l": "UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) = UDP-N-acetyl-alpha-D-glucosamine(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37368", "l": "CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine => 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65190", "l": "berkeleydione + CO2 + H2O + succinate => 2-oxoglutarate + berkeleyone B + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186778", "l": "SHP2 binds to the active receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57664", "l": "(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] = alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18839", "l": "CoA + taxuyunnanin C => 10-deacetyltaxuyunnanin C + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56959", "l": "ITP + pyruvate <=> H(+) + IDP + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46737", "l": "H2O + monoacyl-sn-glycero-3-phosphate => a monoacylglycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110360", "l": "Recruitment of POLB to the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75891", "l": "Abortive Initiation After Second Transition (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29420", "l": "H(+)(out) + Na(+)(in) => H(+)(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54548", "l": "D-xylulose 1,5-bisphosphate + H2O = D-xylulose 5-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54767", "l": "5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine <=> [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51893", "l": "H2O + N-acetylcadaverine => acetate + cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019979", "l": "interleukin-4 binding", "d": ["Binding to interleukin-4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32734", "l": "a diacylglycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443774", "l": "Trans-homodimerization of Neurofascin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38284", "l": "itaconate + succinyl-CoA => itaconyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701488", "l": "Active ALK phosphorylates JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429815", "l": "Formation Of Bloc-1 Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209924", "l": "Dopa is decarboxylated to dopamine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62876", "l": "AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate = A + semiviriditoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62081", "l": "D-glucose 6-sulfate + NADP(+) => 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046522", "l": "S-methyl-5-thioribose kinase activity", "d": ["Catalysis of the reaction: S-methyl-5-thio-D-ribose + ATP = S-methyl-5-thio-alpha-D-ribose 1-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34643", "l": "2 S-adenosyl-L-methionine + squalene = 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.262", "l": "\"squalene methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947535", "l": "Cyclisation of GTP to precursor Z (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31252", "l": "(S)-3-hydroxyisobutanoyl-CoA + H2O => (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75856", "l": "Abortive Initiation Before Second Transition (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65662", "l": "AH2 + calcidiol => A + calciol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22229", "l": "H(+) + NADH + presqualene diphosphate => diphosphate + NAD(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20828", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2", "d": []}, {"i": "EC:4.1.1.65", "l": "\"phosphatidylserine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634433", "l": "CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203611", "l": "N-myristoylation of eNOS (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68590", "l": "(6S)-5,6,7,8-tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine + H(+) => (6S)-10-formyltetrahydrofolate + GDP-alpha-D-perosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43129", "l": "guanosine(10) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40117", "l": "CoA + H(+) + hexanoate => H2O + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38746", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9675026", "l": "Formation of the MLL1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814096", "l": "ARL1:GTP binds SCOC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839067", "l": "Phosphorylation of BCR moiety of BCR-FGFR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.198", "l": "\"alpha-mannan endo-1,2-alpha-mannanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033933", "l": "branched-dextran exo-1,2-alpha-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->2)-alpha-D-glucosidic linkages at the branch points of dextrans and related polysaccharides, producing free D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45582", "l": "D-galactaro-1,4-lactone => D-galactaro-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71526", "l": "adenine(out) <=> adenine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169895", "l": "Crk's SH3 domain engages C3G (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322422", "l": "Beta-catenin recruits SMARCA4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452091", "l": "Phosphorylation of IL2RB Y338 enables SHC recruitment (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28084", "l": "(2E)-butenoyl-CoA + CO2 + NADPH => (2S)-ethylmalonyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047179", "l": "platelet-activating factor acetyltransferase activity", "d": ["Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38786", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429714", "l": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635861", "l": "NUMB:ITCH binds GLI1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53101", "l": "2-hydroxyestrone + S-adenosyl-L-methionine => 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381283", "l": "Expression of PPARG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35325", "l": "(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH => (S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47283", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47016", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O = [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41007", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin = 6-linalyl-2-O,3-dimethylflaviolin + diphosphate", "d": []}, {"i": "EC:2.5.1.124", "l": "\"6-linalyl-2-O,3-dimethylflaviolin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30539", "l": "(R)-carnitinyl-CoA = (S)-carnitinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381608", "l": "cAMP activates EPAC2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14481", "l": "2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": []}, {"i": "EC:3.1.3.87", "l": "\"2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266328", "l": "CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51347", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712084", "l": "PI3K synthesizes PIP3 downstream of ALK mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951644", "l": "Release of mature NEDD8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75495", "l": "n H(+)(out) + pregnenolone sulfate(out) = n H(+)(in) + pregnenolone sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0004345", "l": "glucose-6-phosphate dehydrogenase activity", "d": ["Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11574", "l": "chenodeoxycholate + FADH2 => FAD + H(+) + H2O + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227867", "l": "TANK binds polyubiquitinated TRAF3/6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031706", "l": "subtype 3 bombesin receptor binding", "d": ["Binding to a subtype 3 bombesin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796368", "l": "RIPK1 binds STUB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9609921", "l": "SGTA binds Tail-anchored protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0090681", "l": "GPCR taste receptor activity", "d": ["A G protein-coupled receptor activity that is responsible for the sense of taste."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210298", "l": "Interaction of DAP12 and KIR3DS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034714", "l": "type III transforming growth factor beta receptor binding", "d": ["Binding to a type III transforming growth factor beta receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11230", "l": "(2S)-flavanone + H(+) + NADPH => (2S)-flavan-4-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755413", "l": "SARS-CoV-2 8 binds IL17RA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949580", "l": "F1Fo ATP synthase dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432148", "l": "Fgr may phosphorylate p38 MAPK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003947", "l": "(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74772", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine => 3,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10501", "l": "butanoyl-CoA + glyoxylate + H2O => 3-ethylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419841", "l": "Light stimulates opsin receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625426", "l": "Retrograde IFT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0000268", "l": "peroxisome targeting sequence binding", "d": ["Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74241", "l": "alpha-D-glucose 1-phosphate + D-galactose => phosphate + solabiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944220", "l": "Association of procollagen type XXIII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73367", "l": "D-xylose(out) + 2 Na(+)(out) = D-xylose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35481", "l": "(S)-5'-oxoaverantin + 2 H(+) + NADH => (1'S,5'R)-5'-hydroxyaverantin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9718020", "l": "PTGFR binds PTGFR agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2464822", "l": "RDH12 reduces atRAL to atROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112342", "l": "Inactivation of MAP2K1 by CDK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-217255", "l": "FMO1:FAD N-oxidises TAM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64989", "l": "CoA + H2O => (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165179", "l": "Formation of TSC1:TSC2 complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66879", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23127", "l": "2 (2R)-3-phosphoglycerate + 2 H(+) <=> CO2 + D-ribulose 1,5-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678998", "l": "Endosomal TLRs pass through the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12463", "l": "(S)-malate <=> fumarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24548", "l": "an N(6)-acyl-L-lysine + H2O = a carboxylate + L-lysine", "d": []}, {"i": "EC:3.5.1.17", "l": "\"acyl-lysine deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693071", "l": "BACE1 translocates from ER lumen to Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.117", "l": "\"6-aminohexanoate-oligomer endohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686359", "l": "SFTPs translocate from extracellular region to clathrin-coated vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247840", "l": "WLS binds WNT ligands in the Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33829", "l": "vitamin D2 => ergosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042281", "l": "dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity", "d": ["Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76056", "l": "norreticuline + S-adenosyl-L-methionine => H(+) + reticuline + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58187", "l": "H(+) + NADPH + 2 phytyl diphosphate <=> (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15515", "l": "ADP + H(+) + keto-D-tagatose 6-phosphate => ATP + keto-D-tagatose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73127", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine = 4',8-dihydroxy-7-methoxyflavone + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222384", "l": "Glutathione scavenges nitrosyl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873926", "l": "IFNG dimer binds IFNGR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067640", "l": "IL6 binds IL6R-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34063", "l": "2-deoxystreptamine + UDP-alpha-D-glucose = 2'-deamino-2'-hydroxyparomamine + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.284", "l": "\"2-deoxystreptamine glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11831", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O <=> a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38559", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate = (R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75542", "l": "(2E)-decenoate + ATP + holo-[ACP] <=> (2E)-decenoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35825", "l": "7,8-dihydromethanopterin + H(+) + NADH => 5,6,7,8-tetrahydromethanopterin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65830", "l": "diphosphate + nerol => H2O + neryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75362", "l": "L-mimosine <=> 2-aminoprop-2-enoate + 3-hydroxy-4H-pyrid-4-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008911", "l": "lactaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65029", "l": "(+)-pinoresinol + H2O + 2 oxidized [azurin] => (+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379996", "l": "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.188", "l": "\"beta-geranylfarnesene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20349", "l": "H(+) + NADH + O2 + toluene = 2-hydroxytoluene + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807585", "l": "BPI binds LPS on the bacterial surface (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097244", "l": "flavonol binding", "d": ["Binding to a flavonol, a flavonoid that contains a 3-hydroxy-2-phenylchromen-4-one backbone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61913", "l": "ATP + H2O + voriconazole(in) => ADP + H(+) + phosphate + voriconazole(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928619", "l": "PAK1 binds RAC1:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17553", "l": "ATP + guanidinoethyl methyl phosphate = ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate", "d": []}, {"i": "EC:2.7.3.7", "l": "\"opheline kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47400", "l": "3-oxo-(9Z-octadecenoyl)-CoA + CoA = (7Z)-hexadecenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362386", "l": "Glycosylation of Hh (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73859", "l": "1-methylnicotinamide(out) = 1-methylnicotinamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158860", "l": "SULT1A1 dimer sulfonates NHABP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426032", "l": "DAG is metabolized by DAGL to 2-AG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62621", "l": "[thioredoxin]-dithiol + a hydroperoxide => [thioredoxin]-disulfide + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11899", "l": "7alpha-hydroxycholesterol + NAD(+) <=> 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578965", "l": "TNRC6A binds AGO2:miRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390663", "l": "ADRA2A,B,C bind ADR,NAd (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140778", "l": "microtubule stabilizing activity", "d": ["A protein-containing complex stabilizing activity that prevents dissociation of microtubules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41943", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate <=> [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33492", "l": "2-hydroxyhexacosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296043", "l": "Activation of HCN channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41267", "l": "H2O + N-(15Z-tetracosenoyl)-sphing-4-enine = (15Z)-tetracosenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21091", "l": "2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 <=> a flavonol + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42566", "l": "pseudouridine(38/39) in tRNA => uridine(38/39) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19305", "l": "3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA = 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA", "d": []}, {"i": "EC:2.3.1.151", "l": "\"2,3',4,6-tetrahydroxybenzophenone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42776", "l": "adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.180", "l": "\"16S rRNA (adenine(1408)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15197", "l": "a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.72", "l": "\"site-specific DNA-methyltransferase (adenine-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43658", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41363", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437118", "l": "GPVI stimulates PI3K beta, gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58653", "l": "rifamycin SV ortho-naphthoquinone carboxamide => rifamycin SV para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37332", "l": "H2O + L-methionyl-L-alanine => L-alanine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982807", "l": "JAK2 phosphorylation of GHR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65899", "l": "glyoxylate + L-kynurenine <=> glycine + H2O + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202466", "l": "Interaction of Bcl10 to CARMA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46819", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.179", "l": "\"brassinosteroid 6-oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25517", "l": "an acyl-CoA + tropine => CoA + H(+) + O-acyltropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013006", "l": "RHOA:GTP translocates to the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24806", "l": "(2S)-2-acetolactate + thiamine diphosphate => 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12053", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + trichodiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70833", "l": "L-arginine(out) + L-leucine(in) + Na(+)(in) => L-arginine(in) + L-leucine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66220", "l": "asc-omegaC7-CoA + O2 = asc-omegaDeltaC7-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50163", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42353", "l": "(R)-nicotine + A + H2O => (R)-6-hydroxynicotine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14168", "l": "acetyl-CoA + L-aspartate <=> CoA + H(+) + N-acetyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18913", "l": "a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47208", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814695", "l": "PERP binds desmosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63432", "l": "1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30520", "l": "GTP + H(+) + phosphoenolpyruvate => diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156699", "l": "Inactivation of Wee1 kinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19325", "l": "H(+) + NADH + O2 + quinolin-4-ol = H2O + NAD(+) + quinoline-3,4-diol", "d": []}, {"i": "EC:1.14.13.62", "l": "\"4-hydroxyquinoline 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007625", "l": "RBBP8 gene expression is inhibited by E2F6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193686", "l": "p75NTR interacts with IRAK:MYD88 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27634", "l": "5-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60562", "l": "S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein] => L-methionyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12123", "l": "alpha-D-glucose 1-phosphate + ATP + H(+) <=> ADP-alpha-D-glucose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018567", "l": "styrene dioxygenase activity", "d": ["Catalysis of the reaction: styrene + O2 + NADH + H+ = NAD+ + styrene cis-glycol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28056", "l": "formate + propanoyl-CoA => 2-oxobutanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32769", "l": "2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine => cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40128", "l": "an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55906", "l": "6,7-dichloro-L-tryptophan + FAD + 2 H2O => 7-chloro-L-tryptophan + chloride + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23133", "l": "3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] => 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34330", "l": "4-nitrophenol + H(+) + NADPH + O2 <=> 1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63326", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17873", "l": "an R-cob(III)alamin(out) + ATP + H2O = ADP + an R-cob(III)alamin(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.6.2.8", "l": "\"ABC-type vitamin B12 transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24968", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = H2O + 2 oxidized [adrenodoxin] + secalciferol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55993", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72979", "l": "didemethylasterriquinone D + dimethylallyl diphosphate = asterriquinone C1 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634850", "l": "NPAS4 binds ARNT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429449", "l": "Syk activation leads to SLP-76 activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3782535", "l": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69930", "l": "adenosine(out) + Na(+)(out) <=> adenosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44499", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine <=> 2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38645", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28266", "l": "(2E,6E)-farnesyl diphosphate = (S)-beta-bisabolene + diphosphate", "d": []}, {"i": "EC:4.2.3.55", "l": "\"(S)-beta-bisabolene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0005391", "l": "P-type sodium:potassium-exchanging transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733331", "l": "CSF1 dimer,IL34 dimer:p-Y561-CSF1R:GRB2:SOS1 dissociates yielding CSF1 dimer,IL34 dimer:p-Y561-CSF1R:SFK and GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31998", "l": "(2E,6E)-farnesyl diphosphate <=> 7-epi-sesquithujene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56052", "l": "2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}, {"i": "EC:3.2.1.114", "l": "\"mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-937034", "l": "IRAK1 phosphorylates Pellino (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615910", "l": "SUMOylation of PCNA with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69719", "l": "(indol-3-yl)acetate + ATP + H(+) = (indol-3-yl)acetyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788867", "l": "FN3K phosphorylates ketosamines (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070411", "l": "I-SMAD binding", "d": ["Binding to an inhibitory SMAD signaling protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44954", "l": "NADP(+) + octanoyl-CoA => (2E)-octenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852200", "l": "Inactivation of LCK by PTPN22 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050588", "l": "apo-beta-carotenoid-14',13'-dioxygenase activity", "d": ["Catalysis of the reaction: 8'-apo-beta-carotenol + O2 = (E,E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.157", "l": "\"iota-carrageenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40644", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17546", "l": "[protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] => [protein]-disulfide + ADP + phosphate + S-hydroxy-L-cysteinyl-[peroxiredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66293", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose => an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44724", "l": "2,3-saturated fatty aldehyde + NADP(+) = (2E)-fatty aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23987", "l": "cholesterol + NADP(+) <=> 7-dehydrocholesterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683467", "l": "CQ, HCQ are protonated to CQ2+, HCQ2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37622", "l": "(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20732", "l": "[protein]-dithiol + [thioredoxin]-disulfide = [protein]-disulfide + [thioredoxin]-dithiol", "d": []}, {"i": "EC:1.8.4.16", "l": "\"thioredoxin:protein disulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45236", "l": "(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77608", "l": "Binding of A1CF to stem-looped RNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031822", "l": "type 1B serotonin receptor binding", "d": ["Binding to a type 1B serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55174", "l": "2-hydroxyhexanoyl-CoA + CO2 + succinate => 2-oxoglutarate + hexanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75746", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH <=> 10-hydroxy-(11E)-octadecenoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48740", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine = [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate", "d": []}, {"i": "EC:2.5.1.113", "l": "\"[CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22122", "l": "GDP + phosphate + succinyl-CoA => CoA + GTP + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13392", "l": "glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68812", "l": "(2Z,6E)-farnesyl diphosphate = beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218804", "l": "p38 MAPK activation by VEGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66004", "l": "coenzyme M + methyl-Co(III)-[glycine betaine-specific corrinoid protein] = Co(I)-[glycine betaine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}, {"i": "EC:2.1.1.377", "l": "\"[methyl-Co(III) glycine betaine-specific corrinoid protein]--coenzyme M methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17644", "l": "H(+) + L-arginine <=> agmatine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13765", "l": "bromochloromethane + H2O = bromide + chloride + formaldehyde + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390438", "l": "FAR2 reduces PalmCoA to HXOL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694421", "l": "PP6 dephosphorylates SEC24 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52869", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate => 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70456", "l": "(6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800298", "l": "HGF dimer binds MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26239", "l": "(2E,6E,10E)-geranylgeraniol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140933", "l": "5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity", "d": ["Catalysis of the reaction: a 5'-end (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + N7-methyl-GDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130151", "l": "Dimerization of DAP12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23823", "l": "GDP-alpha-D-mannose <=> GDP-4-dehydro-alpha-D-rhamnose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43003", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63971", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) <=> atromentin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66387", "l": "(2E,6E,10E,14E)-geranylfarnesol <=> scalar-17(25)-en-19-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163625", "l": "Glucagon binds to Glucagon receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36418", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine <=> diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74084", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + menadiol => diphosphate + menaquinol-4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20937", "l": "2,3-dihydroxy-3-methylbutanoate => 3-methyl-2-oxobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23549", "l": "guanosine(966) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202960", "l": "Caspase mediated cleavage of C-IAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48306", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34668", "l": "C30 botryococcene + S-adenosyl-L-methionine => 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37532", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58147", "l": "acetate + ATP + cytidine(34) in elongator tRNA(Met) <=> AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67493", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21289", "l": "D-glucose + sn-glycerol 3-phosphate => D-glucose 6-phosphate + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71200", "l": "L-ornithine(in) => L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73195", "l": "malonate(in) + sulfate(out) = malonate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17689", "l": "3'-phosphoadenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)", "d": []}, {"i": "EC:2.8.2.34", "l": "\"glycochenodeoxycholate sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41445", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate + O2 => glycine + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45043", "l": "2 Fe(III)-[cytochrome c] + hydroxylamine <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + nitroxyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59631", "l": "H2O + N(2)-(4-aminobutanoyl)-L-arginine <=> 4-aminobutanoate + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450466", "l": "AUF1:mRNA complex is destroyed (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21948", "l": "formamide + H2O = formate + NH4(+)", "d": []}, {"i": "EC:3.5.1.49", "l": "\"formamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59156", "l": "ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163554", "l": "Phosphorylated HSL dimer translocates from the cytosol to the lipid particle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13332", "l": "A + a 3-oxosteroid <=> a 3-oxo-Delta(1)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202127", "l": "eNOS synthesizes NO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17309", "l": "a phenyl acetate + H2O = a phenol + acetate + H(+)", "d": []}, {"i": "EC:3.1.1.2", "l": "\"arylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36951", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2 = (9Z)-heptadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001614", "l": "purinergic nucleotide receptor activity", "d": ["Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047521", "l": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity", "d": ["Catalysis of the reaction: 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP+ = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52067", "l": "13-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64196", "l": "an N-(fatty acyl)-L-lysine + H2O = a fatty acid + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375302", "l": "Kinetochore capture of astral microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173705", "l": "C5b binds C6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618328", "l": "ATAT acetylates microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75561", "l": "cyathadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => erinacol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33130", "l": "H2O + salicin-6-phosphate <=> beta-D-glucose 6-phosphate + salicyl alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418553", "l": "cAMP degradation by Phosphodiesterases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607734", "l": "PKC-delta translocates to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46863", "l": "3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate <=> 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043262", "l": "ADP phosphatase activity", "d": ["Catalysis of the reaction: ADP + H2O = AMP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692146", "l": "Expression of DHH in testis differentiation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949580", "l": "F1Fo ATP synthase dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58827", "l": "4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22159", "l": "GDP + H2O <=> GMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62734", "l": "(+)-isomalbrancheamide D + FADH2 => (+)-isomalbrancheamide B + bromide + FAD + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655142", "l": "RCHY1 binds POLH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710959", "l": "p-STAT1 dimer binds KPNA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222128", "l": "NOC2L binds TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050312", "l": "sulfoacetaldehyde lyase activity", "d": ["Catalysis of the reaction: 2-sulfoacetaldehyde + H2O = acetate + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47617", "l": "ethionamide + H(+) + NADPH + O2 => ethionamide S-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679775", "l": "COMT binds COMT Inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34526", "l": "[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose <=> [alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674542", "l": "p-Y-STAT1,3,5 dimerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6791109", "l": "GADD45A binds PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17308", "l": "H2O + N(omega),N(omega)-dimethyl-L-arginine <=> dimethylamine + L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43700", "l": "(2E,6E)-farnesoate + S-adenosyl-L-methionine = methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15354", "l": "all-trans-violaxanthin + L-ascorbate => all-trans-antheraxanthin + H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0043621", "l": "protein self-association", "d": ["Binding to a domain within the same polypeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34273", "l": "1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite => 2-nitroimidazole + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987039", "l": "JAK1 binds IL20RA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37245", "l": "3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32015", "l": "(2E,6E)-farnesyl diphosphate = (-)-delta-cadinene + diphosphate", "d": []}, {"i": "EC:4.2.3.97", "l": "\"(-)-delta-cadinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39711", "l": "O2 + 2 reduced coenzyme F420-(gamma-L-Glu)(n) = 2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.5.3.22", "l": "\"coenzyme F420H2 oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.-.-", "l": "\"Glycosyltransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429860", "l": "DCP1-DCP2 complex decaps mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.82", "l": "\"putrescine--2-oxoglutarate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54050", "l": "4-epi-cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042896", "l": "chloramphenicol transmembrane transporter activity", "d": ["Enables the transfer of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44216", "l": "12-hydroxyoctadecanoate + ATP + CoA = 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40984", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => (9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50041", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-112434", "l": "Formation of DSIF complex  (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57134", "l": "(R)-octopamine + H2O + L-dehydroascorbate => L-ascorbate + O2 + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031852", "l": "mu-type opioid receptor binding", "d": ["Binding to a mu-type opioid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59552", "l": "N,N',N'',N'''-tetraacetylchitotetraose + O2 = H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392749", "l": "Transport of L1 into endosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990699", "l": "palmitoleyl hydrolase activity", "d": ["Catalysis of a hydrolase reaction that removes a palmitoleyl moiety, a 16-carbon monounsaturated fatty acid (C16:1), from some substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624494", "l": "RAF1 binds p21 RAS:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785181", "l": "LMF1,2 bind LIPC dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74330", "l": "O-propanoyl-(R)-carnitine(in) <=> O-propanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.9", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0016672", "l": "oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound."]}, {"i": "EC:1.8.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627089", "l": "CASP9 is phosphorylated at T412 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50426", "l": "prostaglandin G1 => (8Z,11Z,14Z)-eicosatrienoate + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866941", "l": "MID1IP1 binds THRSP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38389", "l": "(9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6791235", "l": "GADD45A binds AURKA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28214", "l": "[thioredoxin]-dithiol + prostaglandin H2 = [thioredoxin]-disulfide + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56996", "l": "aldehydo-D-apiose = apulose", "d": []}, {"i": "EC:5.3.1.36", "l": "\"D-apiose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19137", "l": "17beta-estradiol + AH2 + O2 = 6beta-hydroxyestradiol-17beta + A + H2O", "d": []}, {"i": "EC:1.14.99.11", "l": "\"estradiol 6beta-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56581", "l": "6-thioguanine + S-adenosyl-L-methionine => 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614605", "l": "Persulfide sulfur is dioxygenated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798373", "l": "MDM2 ubiquitinates DYRK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57624", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41068", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38407", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0030551", "l": "cyclic nucleotide binding", "d": ["Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39970", "l": "2-aminobut-2-enoate <=> 2-iminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53117", "l": "an 11beta-hydroxysteroid + NAD(+) => an 11-oxosteroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57394", "l": "3-O-acetyl-4'-O-demethylpapaveroxine + H(+) => (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938217", "l": "RUNX1 binds the SWI/SNF complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797100", "l": "CCNK binds CDK13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70685", "l": "(R)-metanephrine + H(+) + S-adenosyl-L-homocysteine => (R)-normetanephrine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32719", "l": "L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018507", "l": "cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity", "d": ["Catalysis of the reaction: (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD+ = H+ + NADH + phenanthrene-3,4-diol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25814", "l": "3-acetamidopropanal + H2O2 + putrescine => H2O + N(1)-acetylspermidine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008412", "l": "CDK4 phosphorylates RUNX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425861", "l": "Activation of Protein Kinase C novel isoforms (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534359", "l": "CatSper Channel Mediated Calcium Transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63716", "l": "losartan + UDP-alpha-D-glucuronate = losartan-1-N-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12033", "l": "a 3-(acyloxy)acyl derivative of bacterial toxin + H2O => 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451309", "l": "Edited Kainate Receptor binds glutamate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48167", "l": "epoxypheophorbide a + H2O <=> H(+) + red chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67664", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = 1,2-diacyl-sn-glycero-3-phosphoethanolamine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19413", "l": "ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)", "d": []}, {"i": "EC:6.1.1.20", "l": "\"phenylalanine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016691", "l": "chloride peroxidase activity", "d": ["Catalysis of the reaction: 2 R-H + 2 chloride + H2O2 = 2 R-Cl + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443418", "l": "GP1b signaling involves c-Src (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877003", "l": "CBLL1 ubiqutinates the InlA-bound CDH1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45005", "l": "(R)-carnitine + 2,6-dimethylheptanoyl-CoA => CoA + O-2,6-dimethylheptanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029273", "l": "PI3K binds to p-6Y-SYK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28410", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) = 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44283", "l": "2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38656", "l": "6-tuliposide B => D-glucose + tulipalin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174446", "l": "Removal of remaining Flap from the C-strand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62373", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA => (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74483", "l": "(Z)-dehydrocyclopeptine + 2-oxoglutarate + O2 = (-)-cyclopenine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651773", "l": "LIG1 binds POLB at long-patch BER site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55447", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] <=> cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44265", "l": "eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60874", "l": "a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372717", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202241", "l": "Recruitment of SLP-76 to Gads (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36665", "l": "(2S,5S)-5-carboxymethylproline + CO2 + CoA => (S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12023", "l": "a monocarboxylic acid amide + H2O <=> a monocarboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43844", "l": "(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 = (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729849", "l": "SARS-CoV-2 nsp1 binds to 40S ribosomal complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848713", "l": "PTK6 binds BCAR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18976", "l": "2-oxoglutarate + deacetoxyvindoline + O2 <=> 4-O-deacetylvindoline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9005980", "l": "IL21 binds IL21R:JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1006143", "l": "CD46 binds C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015057", "l": "thrombin-activated receptor activity", "d": ["A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26278", "l": "Co-precorrin-4 + S-adenosyl-L-methionine => Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67581", "l": "3'-phosphoadenylyl sulfate + tauro-alpha-muricholate => adenosine 3',5'-bisphosphate + H(+) + tauro-alpha-muricholate 7-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202328", "l": "Translocation of PKC theta to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75079", "l": "Formation of AT-AC C complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68568", "l": "N(5)-hydroxy-L-ornithine = (3S)-1,2-diazinane-3-carboxylate + H(+) + H2O", "d": []}, {"i": "EC:4.8.1.1", "l": "\"L-piperazate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36234", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71828", "l": "arsenate(in) + H(+)(in) => arsenate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-706479", "l": "TAK1 is activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004749", "l": "ribose phosphate diphosphokinase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63820", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) = H(+) + holo-[aryl-carrier protein] + petrobactin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57005", "l": "acetyl-CoA + streptothricin D => CoA + H(+) + N(beta)-acetylstreptothricin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174119", "l": "Free APC/C phosphorylated by Plk1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67784", "l": "2 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol = 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483087", "l": "PI is exchanged with PC by PITPNB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390595", "l": "Calcium Binds Troponin-C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24983", "l": "3-hydroxy-4-methylanthranilate + ATP + H(+) <=> 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2995334", "l": "COX15 transforms heme O to heme A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55430", "l": "11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ferruginol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68545", "l": "(2Z,6Z)-farnesyl diphosphate => (E)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.8", "l": "\"ATP diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202604", "l": "Formation of a heteromeric BMP receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849646", "l": "SPINK5(490-624) binds KLK5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694527", "l": "Loss of SAR1B GTPase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65127", "l": "benzoyl-CoA + ethanol <=> benzyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001079", "l": "beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc binding", "d": ["Binding to beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59557", "l": "H2O + N,N'-diacetylchitobiono-1,5-lactone => H(+) + N,N'-diacetylchitobionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22662", "l": "a fatty acyl-[ACP] + AMP + diphosphate => a fatty acid + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047237", "l": "glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191636", "l": "Phosphorylation of Cx43 by c-src (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73091", "l": "AMP(out) + FMN(in) = AMP(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32813", "l": "benzoate(out) => benzoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202960", "l": "Caspase mediated cleavage of C-IAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669158", "l": "NF2 binds PAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47789", "l": "a cytidine in 28S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46720", "l": "(3R)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73797", "l": "FAICAR => IMP + H2O (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.239", "l": "\"carnitine monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57834", "l": "glutarate + 2 H(+) + NADPH => 5-oxopentanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49783", "l": "docosanoyl-CoA + glycine <=> CoA + H(+) + N-docosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56958", "l": "H(+) + IDP + phosphoenolpyruvate => ITP + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008414", "l": "CDP-alcohol phosphotransferase activity", "d": ["Catalysis of the transfer of a CDP-alcohol group from one compound to another."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.28", "l": "\"S-methyl-5'-thioadenosine phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64892", "l": "holo-[ACP] + tetradecanoyl-AMP = AMP + H(+) + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0072544", "l": "L-DOPA binding", "d": ["Binding to L-DOPA, the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69226", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate + D-glucose + H(+) => a (Z)-alkenyl glucosinolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250930", "l": "B-WICH recruits histone acetyltransferases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18158", "l": "ATP + pyruvate => ADP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71628", "l": "phosphate(in) + succinate(out) => phosphate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018817", "l": "RHOT1 GEFs activate RHOT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655262", "l": "Activated FGFR3 point, translocation and fusion mutants bind FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74615", "l": "PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19185", "l": "glyoxylate + H2O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.11", "l": "\"2-hydroxyglutarate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83650", "l": "FasL:Fas binds FADD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56828", "l": "2,3,6-trichlorohydroquinone + chloride + glutathione disulfide = 2,3,5,6-tetrachlorohydroquinone + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46086", "l": "glycerol + phosphate => H2O + sn-glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986083", "l": "USP33 deubiquitinates ROBO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44103", "l": "H2O + NAD(+) + octanal <=> 2 H(+) + NADH + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189488", "l": "UROS transforms HMB to URO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72864", "l": "3',3',3'-cAAG + H2O => G[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63018", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+) => (5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390930", "l": "5-HT2 receptor can bind serotonin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35197", "l": "L-quinate(out) => L-quinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15463", "l": "3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928640", "l": "PAKs phosphorylate MLC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004014", "l": "adenosylmethionine decarboxylase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + H+ = S-adenosylmethioninamine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28233", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19722", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65321", "l": "2-oxoglutarate + chrodrimanin E + O2 => chrodrimanin A + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50181", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199014", "l": "CD96 binds PVR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22939", "l": "H2O + N-acetyl-D-glucosamine 6-phosphate <=> acetate + D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73718", "l": "UBF-1 Binds rDNA Promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800490", "l": "ATM phosphorylates PIDD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0004565", "l": "beta-galactosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018636", "l": "phenanthrene 9,10-monooxygenase activity", "d": ["Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848939", "l": "PTK6 binds KHDRBS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51889", "l": "2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) => 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22601", "l": "H2O + N-acetyl-9-O-acetylneuraminate => acetate + H(+) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63580", "l": "20-hydroxyecdysone 22-phosphate + H2O = 20-hydroxyecdysone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102573", "l": "aminodeoxyfutalosine synthase activity", "d": ["Catalysis of the reaction: 3-[(1-carboxylatovinyl)oxy]benzoate(2-) + S-adenosyl-L-methionine + H2O <=> aminodeoxyfutalosinate + L-methionine + hydrogencarbonate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391939", "l": "TP receptor can bind thromboxane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63057", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine => 5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24971", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> H2O + 2 oxidized [adrenodoxin] + secalciferol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793955", "l": "Defective MGAT2 does not transfer GlcNAc to N-glycans (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18351", "l": "AMP + diphosphate + L-aspartyl-tRNA(Asx) => ATP + L-aspartate + tRNA(Asx)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10794", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2 => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24449", "l": "enterobactin + UDP-alpha-D-glucose => monoglucosyl-enterobactin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37017", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63200", "l": "(10bS,4aR)-noroxomaritidine + H(+) + NADPH = (10bS,4aR)-oxomaritidine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49204", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693347", "l": "CRYM reduces P2C to PPCA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033921", "l": "capsular-polysaccharide endo-1,3-alpha-galactosidase activity", "d": ["Catalysis of the random hydrolysis of (1->3)-alpha-D-galactosidic linkages in Aerobacter aerogenes capsular polysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.10", "l": "\"streptopain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051425", "l": "PTB domain binding", "d": ["Binding to a phosphotyrosine-binding (PTB) Binding to a phosphotyrosine-bindin domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707690", "l": "BACH1 binds MAFK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73563", "l": "dGDP(out) + UTP(in) = dGDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030626", "l": "U12 snRNA binding", "d": ["Binding to a U12 small nuclear RNA (U12 snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41721", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015047", "l": "NADPH-cytochrome-c2 reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4549334", "l": "Defective DPAGT1 does not transfer GlcNAc to DOLP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211904", "l": "CYP4F12 18-hydroxylates ARA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63427", "l": "(2S)-2-phospholactate + GTP + H(+) <=> (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "56.232392044945293", "identifiers": [{"i": "GO:0140640", "l": "catalytic activity, acting on a nucleic acid", "d": ["Catalytic activity that acts to modify a nucleic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58203", "l": "2-oxoglutarate + 6-aminohexanoate <=> 6-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14868", "l": "S-adenosyl-L-methionine + tyramine <=> H(+) + N-methyltyramine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647632", "l": "CASP3 cleaves GSDME (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28106", "l": "galactitol 1-phosphate + NAD(+) = H(+) + keto-D-tagatose 6-phosphate + NADH", "d": []}, {"i": "EC:1.1.1.251", "l": "\"galactitol-1-phosphate 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174444", "l": "Formation of C-strand Okazaki fragments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69074", "l": "Formation of Processive Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9703895", "l": "CASR binds CASR agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21455", "l": "a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 <=> a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39042", "l": "an omega-oxo fatty acid + H2O + NAD(+) <=> a dicarboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070016", "l": "armadillo repeat domain binding", "d": ["Binding to an armadillo repeat domain, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947531", "l": "Molybdenum ion transfer onto molybdopterin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433418", "l": "Phosphorylation of JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10187", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O <=> 3-oxoadipate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202222", "l": "Phosphorylation of PKC theta (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28914", "l": "H(+)(out) + L-lysine(out) <=> H(+)(in) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22450", "l": "ADP + H(+) + psi-UMP => ATP + pseudouridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65432", "l": "a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14203", "l": "D-xylulose => D-lyxose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351894", "l": "Caspase mediated cleavage of BAP31 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-434650", "l": "MATEs mediate extrusion of xenobiotics (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2990882", "l": "CDK1 phosphorylates NUP98 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351871", "l": "Caspase-mediated cleavage of Z0-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033794", "l": "sarcosine reductase activity", "d": ["Catalysis of the reaction: acetyl phosphate + methylamine + thioredoxin disulfide = N-methylglycine + phosphate + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448958", "l": "Nuclear translocation of p38 MAPK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004115", "l": "3',5'-cyclic-AMP phosphodiesterase activity", "d": ["Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47654", "l": "phosphate + ribitol => D-ribitol 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44784", "l": "2-demethylmenaquinol-10 + S-adenosyl-L-methionine = H(+) + menaquinol-10 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.42", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027625", "l": "5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674397", "l": "Imatinib-resistant PDGFR mutants don't bind imatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13510", "l": "H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP => diphosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707659", "l": "Hemes:LY96 activates TLR4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64180", "l": "an N-(fatty acyl)-L-tryptophan + H2O = a fatty acid + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25491", "l": "(2E)-geranyl diphosphate <=> (1S,5S)-alpha-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421439", "l": "4 porphobilinogen + H2O => hydroxymethylbilane + 4 NH3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69325", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate => 4-methylsulfanylbutyl isothionate + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39683", "l": "3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH = (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40605", "l": "(9Z,12Z)-octadecadienoate + glycerol + H(+) => 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004816", "l": "asparagine-tRNA ligase activity", "d": ["Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70205", "l": "5,6-dihydroxyindole-N-methyl => N-methyldopaminechrome", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465940", "l": "atRAL is reduced to atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390673", "l": "CHRM2,4 bind acetylcholine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592297", "l": "Full activation of MMP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29617", "l": "alpha-maltotetraose + beta-D-glucose => alpha-maltotriose + beta-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71742", "l": "2-oxoadipate(in) + 2-oxoglutarate(out) <=> 2-oxoadipate(out) + 2-oxoglutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42455", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate <=> H2O + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098769", "l": "TIMP family protein binding", "d": ["Binding to a member of the Tissue inhibitors of metalloproteinases (TIMPs) family. TIMPs are endogenous protein regulators of the matrix metalloproteinase (MMPs) family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943080", "l": "TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63273", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 => 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9006870", "l": "IL21 receptor STAT phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42934", "l": "2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61137", "l": "(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + quercetin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75416", "l": "H2O + N-methylmyosmine => pseudooxynicotine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11120", "l": "cyanate + 3 H(+) + hydrogencarbonate = 2 CO2 + NH4(+)", "d": []}, {"i": "EC:4.2.1.104", "l": "\"cyanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64350", "l": "deacetylpyripyropene E => 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23318", "l": "2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil => 2'-deoxyuridine + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10230", "l": "cis-aconitate + H2O => citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66460", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O = 14betaH-scalarane-17alpha-19-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607744", "l": "MALT1 binds BCL10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420131", "l": "The PACAP receptor binds PACAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050193", "l": "phosphoketolase activity", "d": ["Catalysis of the reaction: D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20584", "l": "H2O + NAD(+) + NH4(+) <=> 2 H(+) + hydroxylamine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139941", "l": "Binding of IP3 to IP3 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68318", "l": "1D-myo-inositol 2,4,5-triphosphate + phosphate => 1D-myo-inositol 2,3,4,5-tetrakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-879459", "l": "F-actin capping protein is a heterodimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043817", "l": "phosphosulfolactate synthase activity", "d": ["Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029680", "l": "Caspase-7 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112690", "l": "PTPN11 binds CBL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0033765", "l": "steroid dehydrogenase activity, acting on the CH-CH group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor, and in which one substrate is a sterol derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16407", "l": "benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH => benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55877", "l": "apo-[aequorin] + coelenterazine => apo-[aequorin]--coelenterazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674019", "l": "BRAP binds KSR1:MARK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49274", "l": "calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67028", "l": "(glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O = (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67353", "l": "malonyl-CoA + rhaponticin => 6-O-malonyl-rhaponticin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873946", "l": "OTUD3 deubiquitinates PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23085", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA => 7-methyl-3-oxooct-6-enoyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.240751554780076", "identifiers": [{"i": "GO:0015036", "l": "disulfide oxidoreductase activity", "d": ["Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45175", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114254", "l": "CYCS binds to APAF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047114", "l": "kynurenate-7,8-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: 7,8-dihydro-7,8-dihydroxykynurenate + NAD+ = 7,8-dihydroxykynurenate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730840", "l": "Activation of RAC1 by VAV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50649", "l": "2-(2-methylsulfanyl)ethylmalate => 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.24", "l": "\"phenylalanine ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170159", "l": "Translocation of Cdc25 to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420128", "l": "SRC-1 phosphorylates SHB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693111", "l": "RHOF auto-activates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061676", "l": "importin-alpha family protein binding", "d": ["Binding to a member of the importin-alpha family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77081", "l": "Formation of the CE:GMP intermediate complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71759", "l": "2-oxoglutarate(out) + heptanedioate(in) = 2-oxoglutarate(in) + heptanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202702", "l": "CD177 binds PECAM-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794344", "l": "HOMER binds SHANK proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.32", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65054", "l": "4-(trifluoromethyl)benzaldehyde + H(+) + NADH => 4-(trifluoromethyl)benzyl alcohol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62064", "l": "2-deoxy-D-glucose 6-phosphate + NAD(+) = 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437118", "l": "GPVI stimulates PI3K beta, gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65372", "l": "CMP-N-acetyl-beta-neuraminate + globoside GalGb4Cer = CMP + globoside MSGG + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865275", "l": "PDGF-BB clevage by Furin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611721", "l": "β1-agonists bind ADRB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54133", "l": "a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate => a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050006", "l": "isomaltulose synthase activity", "d": ["Catalysis of the reaction: sucrose = 6-O-alpha-D-glucopyranosyl-D-fructofuranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700114", "l": "NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9702849", "l": "CALCR binds gepants (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786101", "l": "IL4 binds IL4R:JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50135", "l": "ethyl hexadecanoate + H2O <=> ethanol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50996", "l": "L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.127", "l": "\"[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197963", "l": "DHFR2 reduces FOLA to DHF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.9.1.3", "l": "\"phosphohistidine phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39016", "l": "22-oxodocosanoate + H2O + NAD(+) => docosanedioate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454916", "l": "The ABCC family mediates organic anion transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54886", "l": "H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide => L-arginyl-[protein] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052739", "l": "phosphatidylserine 1-acylhydrolase activity", "d": ["Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981728", "l": "Factor H binds to membrane-associated C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61745", "l": "steviolbioside + UDP-alpha-D-glucose => stevioside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40094", "l": "26-hydroxyhexacosanoate + NAD(+) <=> 26-oxohexacosanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31535", "l": "2-oxoglutarate + L-arginine + O2 = (S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate", "d": []}, {"i": "EC:1.14.20.7", "l": "\"2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40871", "l": "(9Z)-octadecenoyl-CoA + FAD + H(+) = (2E,9Z)-octadecadienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381545", "l": "Formation of the IGF:IGFBP5:ALS complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164617", "l": "Elongation of Extended Telomeric Chromosome End (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51188", "l": "nitric oxide + superoxide = peroxynitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3321883", "l": "MSL acetylates histone H4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59868", "l": "4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine = 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202245", "l": "Phosphorylation of TBSMs in LAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33629", "l": "AMP + decanoyl-CoA + diphosphate => ATP + CoA + decanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432381", "l": "PDP1 replaces VRI as binder to Clk and cry genes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875591", "l": "DOCK7 activates RAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-984733", "l": "Kinesin-3 is a dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047507", "l": "(deoxy)nucleoside-phosphate kinase activity", "d": ["Catalysis of the reaction: ATP + deoxynucleoside phosphate = ADP + deoxynucleoside diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018594", "l": "MECP2 binds LBR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977301", "l": "Histidine is decarboxylated to histamine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806831", "l": "CYB5Rs reduce MetHb to HbA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58621", "l": "N-decanoyl-(2S)-hydroxyglycine => decanamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018631", "l": "phenylacetate hydroxylase activity", "d": ["Catalysis of the reaction: phenylacetate + NADH + O2 = NAD+ + OH- + 2-hydroxyphenylacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48682", "l": "a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH => a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9650473", "l": "SERPING1 is secreted (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170012", "l": "histone H3K18 decrotonylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone H3 position 18] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[histone H3] + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852019", "l": "MET bound PI3K generates PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56740", "l": "globoside Gb3Cer + UDP-alpha-D-galactose = GalGb3Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53783", "l": "beta-muricholate + lithocholoyl-CoA <=> beta-muricholoyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27467", "l": "ADP-D-glycero-beta-D-manno-heptose + diphosphate => ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70811", "l": "4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde 3-phosphate = D-xylulose 5-phosphate + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390329", "l": "Dephosphorylation of AKT by PP2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102900", "l": "dehydroabietadienal hydroxylase activity", "d": ["Catalysis of the reaction: dehydroabietadienal + NADPH + O2 <=> dehydroabietic acid + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467794", "l": "Resolution of sister chromatids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805507", "l": "APAF1 binds AVEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69428", "l": "arsenite + 3 glutathione + H(+) = arsenic triglutathione + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653936", "l": "Formation of Ragulator complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21725", "l": "a nitrile + 2 H2O => a carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35172", "l": "H(+)(out) + novobiocin(in) => H(+)(in) + novobiocin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60990", "l": "(E)-hex-2-enal + H(+) + NADH => (E)-hex-2-en-1-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45262", "l": "tetracosanoate(in) => tetracosanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70628", "l": "H2O + N(6)-dodecanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-dodecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25202", "l": "D-ribulose 5-phosphate + formaldehyde => D-arabino-hex-3-ulose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58622", "l": "decanamide + glyoxylate => N-decanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15346", "l": "ATP + L-arginine + L-tyrosine => AMP + diphosphate + H(+) + L-tyrosyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60140", "l": "dodecanoyl-CoA + H(+) + malonyl-CoA = 3-oxotetradecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49949", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 => (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791306", "l": "TP53 stimulates AIFM2 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74740", "l": "Binding of SHC1 to insulin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017188", "l": "aspartate N-acetyltransferase activity", "d": ["Catalysis of the reaction: L-aspartate + acetyl-CoA = N-acetyl-L-aspartate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64716", "l": "NADP(+) + propanal = acrolein + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72089", "l": "2 Na(+)(in) + taurodeoxycholate(in) => 2 Na(+)(out) + taurodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45550", "l": "(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[R-phycocyanin alpha-subunit] => phycourobilin-L-cysteinyl(84)-[R-phycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42276", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] = (4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38120", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol => 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40677", "l": "2-aminobut-2-enoate + H2O => L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75028", "l": "Phosphorylation of Wee1 kinase by Chk1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10296", "l": "D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390402", "l": "Movement of O-hexadecylglycerone phosphate from the peroxisomal matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11902", "l": "2-oxoadipate + CO2 + NADH => (2R,3S)-homoisocitrate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46915", "l": "H2O + juvenile hormone III <=> H(+) + juvenile hormone III carboxylate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374173", "l": "AGT(34-41) binds to AGTR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102802", "l": "thebaine 6-O-demethylase activity", "d": ["Catalysis of the reaction: thebaine + 2-oxoglutarate + O2 <=> neopinone + formaldehyde + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72259", "l": "L-dopa + S-adenosyl-L-methionine = 3-O-methyl-L-dopa + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218805", "l": "PKC autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433606", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14855", "l": "4-hydroxybenzoyl-CoA + chloride + H(+) => 4-chlorobenzoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204871", "l": "Interaction of Tie2 and Grb2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68880", "l": "ATP + H(+) + NADPH + salicylate = AMP + diphosphate + NADP(+) + salicylaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59228", "l": "6-sulfo-alpha-D-quinovose = 6-sulfo-beta-D-quinovose", "d": []}, {"i": "EC:5.1.3.43", "l": "\"sulfoquinovose mutarotase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71655", "l": "an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O = a thymidine in DNA + ADP-D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419268", "l": "TUFM binds GTP displacing TSFM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200646", "l": "Cytosolic folate export across the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688294", "l": "SIRT5 deacetylates Cytochrome C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37442", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate <=> a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29481", "l": "(+)-epicubenol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64679", "l": "3-(methylsulfanyl)propanoyl-CoA + butan-1-ol <=> butyl 3-(methylsulfanyl)propanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954513", "l": "NAA translocates from mitochondrial matrix to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112690", "l": "PTPN11 binds CBL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247847", "l": "WLS is endocytosed to the early endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10144", "l": "a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate", "d": []}, {"i": "EC:3.1.3.6", "l": "\"3'-nucleotidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671772", "l": "p-T38-PPP1R14A binds MLCP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60956", "l": "17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose = (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61531", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base <=> a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50906", "l": "H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine => L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700171", "l": "Active ALK phosphorylates PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31564", "l": "H2O + leukotriene C4 => L-glutamate + leukotriene D4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32043", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = 2 ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43546", "l": "ADP + gamma-L-glutamyltyramine + H(+) + phosphate => ATP + L-glutamate + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17563", "l": "acetate + choline + H(+) => acetylcholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201717", "l": "CSNK2-mediated phosphorylation of DVL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41216", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67606", "l": "diphosphate + H(+) + N(6)-methyl-dAMP => H2O + N(6)-methyl-dATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419049", "l": "ROCK activation by RHO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.249", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14066", "l": "scyllo-inosose => 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034988", "l": "Fc-gamma receptor I complex binding", "d": ["Binding to one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36854", "l": "(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428752", "l": "Dissociation of the TP:Gq complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12658", "l": "a (2S)-2-methylacyl-CoA => a (2R)-2-methylacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102703", "l": "camphene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate <=> (-)-camphene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023845", "l": "ESR1:ESTG binds to proximal and distal regions of the CTSD promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39540", "l": "(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH => (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169402", "l": "ISGylation of E2 conjugating enzymes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59367", "l": "1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28296", "l": "(-)-(E)-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607751", "l": "TRAF6 oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21275", "l": "ATP + glutathione + spermidine <=> ADP + glutathionylspermidine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113451", "l": "Resumption of RNA Polymerase III Productive Transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69173", "l": "Joining of adjacent Okazaki fragments (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44293", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40800", "l": "2-methylpropanoyl-CoA + H2O => 2-methylpropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34917", "l": "D-galactose(out) => D-galactose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50125", "l": "NAD(+) + resolvin D1 => 8-oxoresolvin D1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17466", "l": "H2O + quercitrin => L-rhamnopyranose + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265301", "l": "Corticotropin cleavage from POMC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.945916858897462", "identifiers": [{"i": "GO:0015149", "l": "hexose transmembrane transporter activity", "d": ["Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052809", "l": "acharan sulfate lyase activity", "d": ["Catalysis of the cleavage of a carbon-oxygen bond in acharan sulfate, a glycosaminoglycan with a uniformly repeating disaccharide structure of alpha-D-N-acetylglucosaminyl-2-O-sulfo-alpha-L-iduronic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14367", "l": "CO2 + L-aspartate + NH4(+) => 2 H(+) + H2O + N-carbamoyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043804", "l": "imidazolone hydrolase activity", "d": ["Catalysis of the reaction: N-formimidoylglycine => H2O + imidazol-4-one."]}, {"i": "RHEA:24935", "l": "H2O + imidazol-4-one = N-formimidoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156699", "l": "Inactivation of Wee1 kinase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012086", "l": "Constitutive dimerization of FGFR4 Y367C mutant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25166", "l": "(2E)-butenoyl-CoA + AH2 => A + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202307", "l": "Change of PKC theta conformation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54572", "l": "a uridine in tRNA = a pseudouridine in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617182", "l": "PRKACA phosphorylates PLN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022879", "l": "protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004730", "l": "pseudouridylate synthase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + uracil = H2O + pseudouridine 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-593685", "l": "Netrin-4 binds DCC/UNC5A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19396", "l": "L-lysine + pyruvate <=> (S)-2-amino-6-oxohexanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75920", "l": "H2O + NADP(+) + serinol => dihydroxyacetone + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74059", "l": "PDE6 hydrolyses cGMP to GMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38265", "l": "2-methylfumaryl-CoA + H2O => (2R,3S)-beta-methylmalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27685", "l": "ATP + dTDP <=> ADP + dTTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29652", "l": "agmatine(in) + L-arginine(out) => agmatine(out) + L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851979", "l": "BTNL9 binds immune cell surfaces (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49179", "l": "12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine <=> 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853313", "l": "FGFR2 fusions autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38360", "l": "2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 => thiosulfate + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50137", "l": "ethyl (9Z)-octadecenoate + H2O => (9Z)-octadecenoate + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851352", "l": "CCR8 binds CCL1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141341", "l": "SMOX-3 oxidises SPN to SPM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669868", "l": "Nilotinib-resistant KIT mutants do not bind nilotinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25070", "l": "3-hydroxybenzoate + ATP + CoA = 3-hydroxybenzoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.37", "l": "\"3-hydroxybenzoate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38337", "l": "(20S)-ginsenoside Rg3 + 2 D-glucose => (20S)-ginsenoside Rb1 + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373746", "l": "SEMA4D interacts with CD45 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047711", "l": "blasticidin-S deaminase activity", "d": ["Catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64156", "l": "an N-(fatty acyl)-L-methionine + H2O = a fatty acid + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389348", "l": "Activation of Rac1 by pVav1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013004", "l": "RHOA binds effectors at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007561", "l": "E2F1 binds RAD51 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429441", "l": "SYK activation by SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38240", "l": "(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA => 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867613", "l": "PICALM binds R-SNAREs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16442", "l": "H2O + L-glutaminyl-[protein] => L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388900", "l": "Neurotensin receptors can bind neurotensins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20730", "l": "2-oxoglutarate + H2O2 + NH4(+) => H2O + L-glutamate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964280", "l": "Active Gq binds BTK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31309", "l": "a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30333", "l": "all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.8", "l": "\"2,6-dioxo-6-phenylhexa-3-enoate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61470", "l": "a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69074", "l": "Formation of Processive Complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878186", "l": "CDKN1A gene expression is synergistically activated by RUNX3, SMAD3 and SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38631", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47724", "l": "glutathione = 5-oxo-L-proline + L-cysteinylglycine", "d": []}, {"i": "EC:4.3.2.7", "l": "\"glutathione-specific gamma-glutamylcyclotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13273", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol = 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)", "d": []}, {"i": "EC:2.8.2.19", "l": "\"triglucosylalkylacylglycerol sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033459", "l": "GAA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GAA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617642", "l": "HOXD3 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75586", "l": "11-O-acetylcyathatriol + UDP-alpha-D-xylose <=> erinacine Q + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856951", "l": "PP2A demethylation by PPME1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140383", "l": "4-hydroxytryptamine kinase activity", "d": ["Catalysis of the reaction: 4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797554", "l": "ABP1 binds SHANK proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10422", "l": "L-alanine + sulfoacetaldehyde => pyruvate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.9", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60202", "l": "2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2106614", "l": "Duplex miRNA is loaded into Argonaute (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23936", "l": "D-gluconate + NADP(+) = 5-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952371", "l": "MDM2 binds RUNX3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847880", "l": "CYTH proteins bind ARF1:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37052", "l": "3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25692", "l": "CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0008554", "l": "P-type sodium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out); by a phosphorylative mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65998", "l": "methyl-Co(III)-[glycine betaine-specific corrinoid protein] + N,N-dimethylglycine => Co(I)-[glycine betaine-specific corrinoid protein] + glycine betaine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205136", "l": "GTP-bound RAC contributes to JNK activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75578", "l": "11-O-acetylcyathatriol + A <=> 11-O-acetylcyathin A3 + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60105", "l": "H(+) + indole-3-propanoate + oxidized [electron-transfer flavoprotein] => (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65263", "l": "verruculide C epoxide <=> 3-hydroxypentacecilide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654167", "l": "Activated FGFR1 binds PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134954", "l": "DHX9 binds DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199203", "l": "PANK1/3/4 phosphorylate PanK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018681", "l": "deisopropylatrazine monooxygenase activity", "d": ["Catalysis of the reaction: 2 deisopropylatrazine + O2 = 2 acetaldehyde + 2 deisopropyldeethylatrazine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61896", "l": "betaenone C = betaenone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749505", "l": "LRRC14 binds IKBKB and CHUK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72649", "l": "1,6-dihydroxyphenazine N(5)-oxide + H2O + NADP(+) => 1,6-dihydroxyphenazine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625416", "l": "Anterograde IFT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16062", "l": "H2O + sn-glycerol 3-phosphocholine => choline + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417829", "l": "P2RY12 binds ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23397", "l": "H2O + phloretin => 1,3,5-trihydroxybenzene + H(+) + phloretate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65311", "l": "an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] <=> a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48040", "l": "globoside Gb4Cer + H2O = globoside Gb3Cer + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201630", "l": "Caspase-mediated cleavage of Acinus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102948", "l": "luteolin C-glucosyltransferase activity", "d": ["Catalysis of the reaction: 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate + a glucosylated glucose acceptor = isoorientin + a non glucosylated glucose acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31565", "l": "L-glutamate + leukotriene D4 => H2O + leukotriene C4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60449", "l": "an S-substituted glutathione + H2O => glycine + S-substituted gamma-glutamyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41246", "l": "N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine <=> N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74979", "l": "(3R)-3-isocyanylbutanoate + ATP + H(+) = (3R)-3-isocyanylbutanoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.86", "l": "\"ketol-acid reductoisomerase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16053", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine = H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP", "d": []}, {"i": "EC:2.4.1.187", "l": "\"N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210285", "l": "Trans-homophilic interaction of PECAM-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080130", "l": "L-phenylalanine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51237", "l": "GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n) => GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114558", "l": "Thrombin-activated PARs activate Gq (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031403", "l": "lithium ion binding", "d": ["Binding to a lithium ion (Li+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805546", "l": "Keratin type I binds keratin type II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20799", "l": "aldehydo-D-ribose <=> D-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75844", "l": "ergothioneine(out) + Na(+)(out) => ergothioneine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033679", "l": "3'-5' DNA/RNA helicase activity", "d": ["Unwinding of a DNA/RNA duplex in the 3' to 5' direction, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678920", "l": "TLR processing at low pH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380272", "l": "Plk1-mediated phosphorylation of Nlp (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20377", "l": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009541", "l": "ESR1 binds to TFF1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23442", "l": "4-hydroxybenzoate + chloride + H(+) => 4-chlorobenzoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161563", "l": "PGJ2 is isomerised to delta12-PGJ2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140522", "l": "fusogenic activity", "d": ["The activity of joining two lipid bilayers to form a single membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32810", "l": "thiosulfate(in) <=> thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54931", "l": "3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391933", "l": "EP3 receptor can bind PGE2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2203479", "l": "STAB2 (FEEL-2) binds ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42977", "l": "L-tryptophan => 2-aminoprop-2-enoate + indole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65969", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O => 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.10", "l": "\"2-haloacid dehalogenase (configuration-inverting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0004347", "l": "glucose-6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66815", "l": "5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH <=> 8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0015407", "l": "ABC-type monosaccharide transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monosaccharide(out) = ADP + phosphate + monosaccharide(in). Ribose, xylose, arabinose, galactose and methylgalactoside are imported."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50354", "l": "3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase] => 3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75747", "l": "10-oxooctadecanoate + H(+) + NADH = 10-hydroxyoctadecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74763", "l": "rhamnetin + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033720", "l": "(S)-mandelate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + acceptor = 2-oxo-2-phenylacetate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473594", "l": "Collagen type II degradation by MMP15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209177", "l": "LGS:ARM complex transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68376", "l": "glyoxylate + L-asparagine = 2-oxosuccinamate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655847", "l": "Expression of Lanosterol Demethylase (CYP51A1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66600", "l": "2 dopamine + O2 = 2 dopamine quinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008609", "l": "alkylglycerone-phosphate synthase activity", "d": ["Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950591", "l": "JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25227", "l": "H(+) + L-arabinose + NADH => L-arabinitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62320", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) = (+)-isomalbrancheamide B + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28517", "l": "(R)-carnitine + ATP + CoA <=> (R)-carnitinyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008861", "l": "formate C-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806957", "l": "MET receptor dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050578", "l": "(R)-2-hydroxyacid dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672948", "l": "MARK3 phosphorylates KSR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72672", "l": "The 60S subunit joins the translation initiation complex  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18852", "l": "a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72110", "l": "Na(+)(out) + O-acyl-(R)-carnitine(out) <=> Na(+)(in) + O-acyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173626", "l": "Activation of C1r (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26543", "l": "(R)-piperazine-2-carboxamide + H2O => (R)-piperazine-2-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989777", "l": "Expression of RGL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12875", "l": "4-methyl-2-oxopentanoate + H(+) + NADPH => (R)-2-hydroxy-4-methylpentanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58976", "l": "H2O + malonaldehyde + O2 = 3-oxopropanoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23356", "l": "ATP + L-seryl-[rhodopsin] = ADP + H(+) + O-phospho-L-seryl-[rhodopsin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59044", "l": "dammarenediol-II + UDP-alpha-D-glucose = (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64022", "l": "GDP + H(+) + O-phospho-L-seryl-[protein] => GTP + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549470", "l": "Expression of CRYPTOCHROME-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47615", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64958", "l": "dTMP + 2 H(+) + 2 phosphate => dTTP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27781", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) <=> 2-all-trans-octaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34227", "l": "5-nitrosalicylate + O2 = 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite", "d": []}, {"i": "EC:1.13.11.64", "l": "\"5-nitrosalicylate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51662", "l": "an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+) => an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047482", "l": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity", "d": ["Catalysis of the reaction: L-lysine + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001072", "l": "transcription antitermination factor activity, RNA binding", "d": ["Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43590", "l": "globoside NOR2 + H(+) + UDP => globoside NORint + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47623", "l": "2-ethylhexyl sulfate + 2-oxoglutarate + O2 <=> 2-ethylhexanal + CO2 + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39486", "l": "3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28744", "l": "nitrate(in) + nitrite(out) => nitrate(out) + nitrite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51512", "l": "H2O + oxamate = NH4(+) + oxalate", "d": []}, {"i": "EC:3.5.1.126", "l": "\"oxamate amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2529020", "l": "CK2 phosphorylates condensin I subunits (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044103", "l": "L-arabinose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: L-arabinose + NADP+ = L-arabinono-1,4-lactone + NADPH + H+."]}, {"i": "EC:1.1.1.376", "l": "\"L-arabinose 1-dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63548", "l": "angiotensin-(1-9) + H2O = angiotensin-(1-7) + L-phenylalanyl-L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34455", "l": "all-trans-beta-carotene = 9-cis-beta-carotene", "d": []}, {"i": "EC:5.2.1.14", "l": "\"beta-carotene isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54664", "l": "(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene = pre-alpha-onocerin", "d": []}, {"i": "EC:5.4.99.65", "l": "\"pre-alpha-onocerin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26073", "l": "H2O + UDP-alpha-D-glucuronate = D-glucuronate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22895", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) <=> 5,10-methenyltetrahydrofolate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73259", "l": "cirsiliol + S-adenosyl-L-methionine = eupatorin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014834", "l": "ROBO1,ROBO2 bind SLIT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404134", "l": "RBP4:atROL binds TTR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159773", "l": "Furin cleaves pro-protein S to protein S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222376", "l": "NOX2 generates superoxide from oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73667", "l": "(E,E)-piperoyl-CoA + 2-methylpropan-1-amine = (E,E)-piperlonguminine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0000217", "l": "DNA secondary structure binding", "d": ["Binding to a DNA secondary structure element such as a four-way junction, a bubble, a loop, Y-form DNA, or a double-strand/single-strand junction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64652", "l": "(E)-4-coumaraldehyde + CoA + NADP(+) = (E)-4-coumaroyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30234", "l": "H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine <=> (2E,6E)-farnesal + H2O2 + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008781", "l": "N-acylneuraminate cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714691", "l": "RAC3 binds ER effectors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62450", "l": "AMP + H(+) + L-glutamyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-glutamyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38415", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69005", "l": "Cdc6 protein is phosphorylated by CDK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27955", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + presilphiperfolan-8beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55753", "l": "2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005359", "l": "low-affinity glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20151", "l": "3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + quinine + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26564", "l": "1,4-dihydroxy-2-naphthoyl-CoA + H2O => 2-succinylbenzoyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35682", "l": "dodecanoyl-CoA + H(+) + L-serine <=> 3-oxotetradecasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616241", "l": "CEBPA binds the promoter of the CEBPE gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67582", "l": "adenosine 3',5'-bisphosphate + H(+) + tauro-alpha-muricholate 7-sulfate => 3'-phosphoadenylyl sulfate + tauro-alpha-muricholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52758", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139895", "l": "tBID activates BAK protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48256", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69173", "l": "Joining of adjacent Okazaki fragments (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41380", "l": "H(+) + NADH + O2 + toluene = 4-methylphenol + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.236", "l": "\"toluene 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29744", "l": "2-phenylethylamine(in) => 2-phenylethylamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008746", "l": "NAD(P)+ transhydrogenase activity", "d": ["Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250947", "l": "B-WICH complex binds rDNA promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0003958", "l": "NADPH-hemoprotein reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20481", "l": "3'-phosphoadenylyl sulfate + coelenterazine h = adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate", "d": []}, {"i": "EC:2.8.2.10", "l": "\"Renilla-luciferin sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48468", "l": "ganglioside GM1b (d18:1(4E)) + H2O = ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9770141", "l": "Formation of the Spliceosomal C* complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192051", "l": "CYP7A1 7-hydroxylates CHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45554", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine => H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43018", "l": "2-aminoprop-2-enoate + an alkyl thiol => an S-alkyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.4", "l": "\"phosphatidate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21915", "l": "CoA + H(+) + O2 + pyruvate <=> acetyl-CoA + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40374", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP <=> 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250892", "l": "botF LC cleaves target cell VAMP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001567", "l": "cholesterol 25-hydroxylase activity", "d": ["Catalysis of the reaction: AH(2) + cholesterol + O2 = 25-hydroxycholesterol + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50770", "l": "anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine => 4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102027", "l": "S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity", "d": ["Catalysis of the reaction: 2-demethylmenaquinol-8 + S-adenosyl-L-methionine <=> menaquinol-8 + H+ + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67253", "l": "H2O + malonaldehyde + NAD(+) => 3-oxopropanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031807", "l": "Protectins translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17245", "l": "3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2", "d": []}, {"i": "EC:1.10.3.5", "l": "\"3-hydroxyanthranilate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033756", "l": "Oplophorus-luciferin 2-monooxygenase activity", "d": ["Catalysis of the reaction: Oplophorus luciferin + O2 = oxidized Oplophorus luciferin + CO2 + hnu."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13320", "l": "(2R,3R)-tartrate + H(+) <=> (R)-glycerate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450533", "l": "PKCdelta phosphorylates HuR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66523", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654623", "l": "Activated FGFR3 binds FRS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61400", "l": "ATP + N(6)-(D-ribulosyl)-L-lysine = ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51367", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine <=> CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905577", "l": "ganglioside GP1c binding", "d": ["Binding to ganglioside GP1c."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16987", "l": "H(+) + maleylacetate + NADPH => 3-oxoadipate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42439", "l": "L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-ascorbate 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17461", "l": "D-sedoheptulose 1,7-bisphosphate + H2O = D-sedoheptulose 7-phosphate + phosphate", "d": []}, {"i": "EC:3.1.3.37", "l": "\"sedoheptulose-bisphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64878", "l": "H(+) + phosphate + UMP => H2O + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944261", "l": "Association of procollagen type XIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50892", "l": "a menaquinone + 2 H(+) + hydrogen sulfide + sulfite = a menaquinol + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37940", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16992", "l": "1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57011", "l": "5,5'-dehydrodivanillate + H(+) + NADH + O2 <=> 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632677", "l": "PTCH is internalized (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40275", "l": "hexadecanedioyl-CoA + O2 = (2E)-hexadecenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381644", "l": "ER calcium channels open in response to activated PKA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59149", "l": "ATP + CoA + marinolate C => AMP + diphosphate + marinoloyl-CoA C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19570", "l": "5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine => 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45508", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin beta-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43121", "l": "2-oxoglutarate + O2 + xanthine => CO2 + succinate + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033461", "l": "GGU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GGU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50359", "l": "4-hydroxy-6-methylpretetramide + NADPH + O2 <=> 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3779381", "l": "H2O2 diffuses from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001181", "l": "RNA polymerase I general transcription initiation factor activity", "d": ["A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64807", "l": "acetyl-CoA + S-(2-aminoethyl)-L-cysteine <=> CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70150", "l": "6-deoxo-28-norcastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 28-norcastasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46837", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27892", "l": "phosphate + uridine => 3'-UMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.32", "l": "\"brachyurin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44070", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57974", "l": "eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62686", "l": "H(+) + rubrofusarin + S-adenosyl-L-homocysteine => norrubrofusarin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016223", "l": "beta-alanine-pyruvate transaminase activity", "d": ["Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34934", "l": "glutathioselenol + NADPH <=> glutathione + hydrogenselenide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64645", "l": "butan-1-ol + propanoyl-CoA => butyl propanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955794", "l": "PGP:Mg2+ dimer hydrolyses 3PG to glycerol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2752118", "l": "SPP1 (osteopontin) binds Integrin alpha4beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696146", "l": "AOC2 deaminates TYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59293", "l": "beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O => D-galactose + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769383", "l": "CBY1 binds beta-catenin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170799", "l": "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47018", "l": "[DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13924", "l": "ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2197770", "l": "STAB1 (FEEL-1) binds ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029476", "l": "Role of myosins in phagosome formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692764", "l": "MAPK6 binds CCND3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252001", "l": "ATP1B4 binds SNW1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534365", "l": "Slo3 Potassium Transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878654", "l": "ACP6 hydrolyses MYS-LPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65344", "l": "H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209910", "l": "Iodide is taken up by thyroid epithelial cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42130", "l": "a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.64", "l": "\"4-hydroxybenzoate 1-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57636", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate = holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0001216", "l": "DNA-binding transcription activator activity", "d": ["A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19547", "l": "glycerol + H(+) + phosphocholine => H2O + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20557", "l": "2 H(+) + H2O + urea = CO2 + 2 NH4(+)", "d": []}, {"i": "EC:3.5.1.5", "l": "\"urease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61963", "l": "a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53136", "l": "(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) = 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706287", "l": "Active FLT3 binds to ABL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008793", "l": "aromatic-amino-acid:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57307", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP <=> glycolate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.58", "l": "\"2-dehydro-3-deoxygalactonokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18893", "l": "a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.239", "l": "\"flavonol-3-O-glucoside glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34379", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose = beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP", "d": []}, {"i": "EC:2.4.1.287", "l": "\"rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,4/1,5-galactofuranosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56801", "l": "apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide => cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166119", "l": "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928615", "l": "EFNBs bind SFKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008957", "l": "phenylacetaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198669", "l": "p38MAPK phosphorylates MSK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30615", "l": "15-cis-phytoene + 2 A = 2 AH2 + all-trans-zeta-carotene", "d": []}, {"i": "EC:1.3.99.29", "l": "\"phytoene desaturase (zeta-carotene-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34307", "l": "4-nitrocatechol + NADPH + O2 = 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047014", "l": "glycerol-3-phosphate 1-dehydrogenase [NADP+] activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + NADP+ = D-glyceraldehyde 3-phosphate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27765", "l": "CTP + H2O <=> CMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31887", "l": "(S)-2,3-epoxysqualene = tirucalladienol", "d": []}, {"i": "EC:5.4.99.56", "l": "\"tirucalladienol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622840", "l": "HSPA8 dissociates from LAMP2A-bound substrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191303", "l": "FDPS dimer transfers IPPP to GPP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60316", "l": "N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66074", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine => 4-methyl-2-oxopentanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735775", "l": "Defective PNP does not convert (deoxy)inosine to hypoxanthine and (deoxy)ribose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033219", "l": "urea binding", "d": ["Binding to urea, a water-soluble carboxamide with the structure H2N-CO-NH2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111264", "l": "Addition of nucleotides between position +11 and +30 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783681", "l": "LIF binds LIFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20304", "l": "ATP + L-arginine + tRNA(Arg) <=> AMP + diphosphate + L-arginyl-tRNA(Arg)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202510", "l": "Activation of TAK1-TAB2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37680", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196964", "l": "RFK:Mg2+ phosphorylates RIB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61649", "l": "ATP + holo-[non-ribosomal peptide synthase] + salicylate => AMP + diphosphate + salicyl-[non-ribosomal peptide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392530", "l": "p-S400-Cot phosphorylates NIK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12291", "l": "an alpha-L-fucoside + H2O <=> an alcohol + L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65992", "l": "calciol + hnu = 5,6-trans-vitamin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14817", "l": "4-maleylacetoacetate = 4-fumarylacetoacetate", "d": []}, {"i": "EC:5.2.1.2", "l": "\"maleylacetoacetate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38365", "l": "glycerol + H(+) + octadecanoate => 1-octadecanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061896", "l": "all-trans retinol 3,4-desaturase activity", "d": ["Catalysis of the reaction: all-trans-retinol + 2 H+ + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinol + 2 H2O + 2 oxidized [adrenodoxin]."]}, {"i": "RHEA:50292", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}, {"i": "EC:1.14.19.53", "l": "\"all-trans-retinol 3,4-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69331", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate <=> 5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45205", "l": "Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol => H2O + methyl-Co(III)-[methanol-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73701", "l": "ADP(out) + dATP(in) => ADP(in) + dATP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031809", "l": "H3 histamine receptor binding", "d": ["Binding to a H3 histamine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174445", "l": "RPA binds to the Flap on the C-strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40916", "l": "1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157124", "l": "NOTCH3 binds JAG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28788", "l": "4-hydroxy-L-threonine + ATP => 4-(phosphooxy)-L-threonine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981665", "l": "C4b binding protein binds Protein S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804099", "l": "HMGB1 binds LTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1236970", "l": "Proteasomal clevage of exogenous antigen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48628", "l": "a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33126", "l": "all-trans-heptaprenyl diphosphate <=> (R)-tetraprenyl-beta-curcumene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686174", "l": "Accessory proteins are recruited to the maturing virion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22095", "l": "(3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin] <=> 15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61511", "l": "peonidin + UDP-alpha-D-glucose <=> peonidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29955", "l": "H(+)(in) + thymidine(in) = H(+)(out) + thymidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65346", "l": "(2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937177", "l": "AHR:TCDD binds ARNT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49240", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) = L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)", "d": []}, {"i": "EC:2.7.1.193", "l": "\"protein-N(pi)-phosphohistidine--N-acetyl-D-glucosamine phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50999", "l": "L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "64.381173084437549", "identifiers": [{"i": "GO:0043168", "l": "anion binding", "d": ["Binding to an anion, a charged atom or group of atoms with a net negative charge."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005460", "l": "UDP-glucose transmembrane transporter activity", "d": ["Enables the transfer of a UDP-glucose from one side of a membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57938", "l": "5-pyridoxate + 2 H(+) + NADH => H2O + isopyridoxal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168893", "l": "Binding of NEP/NS2 to vRNP:M1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62103", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22779", "l": "2 H(+) + H2O2 + 2 Mn(2+) <=> 2 H2O + 2 Mn(3+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25304", "l": "7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+) => 7,8-dihydroneopterin 3'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47153", "l": "2,5-dioxopentanoate + H2O + NAD(+) => 2-oxoglutarate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17095", "l": "1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26526", "l": "a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.119", "l": "\"enoyl-CoA hydratase 2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61740", "l": "steviolmonoside + UDP-alpha-D-glucose = H(+) + steviolbioside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868071", "l": "Clathrin recruits PIK3C2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26424", "l": "adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate => 3'-phosphoadenylyl sulfate + thyroxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17012", "l": "2-succinylbenzoate + ATP + CoA <=> 2-succinylbenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20310", "l": "2 H2O2 => 2 H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428918", "l": "Dissociation of the TP:G13 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912450", "l": "ATR Kinase is recruited to unsynapsed regions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25530", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668714", "l": "RAC1:GTP binds NOX1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57482", "l": "2,3-dihydroxydodecanoate + H2O => 2-hydroxydodecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58799", "l": "a flavonol 7-O-beta-D-glucoside + malonyl-CoA <=> a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74008", "l": "dimethylallyl diphosphate + H2O + yaequinolone E => [(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51245", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10797", "l": "albendazole + H(+) + NADPH + O2 => albendazole S-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76051", "l": "(S)-scoulerine + S-adenosyl-L-methionine = (S)-cis-N-methylscoulerine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35991", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17348", "l": "(S)-methylmalonyl-CoA + H2O <=> CoA + H(+) + methylmalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353526", "l": "Repair of ~27-30 bp long patch by DNA Pol Epsilon (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43654", "l": "3-oxododecanoyl-[ACP] + CO2 + CoA => decanoyl-CoA + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29801", "l": "ADP + D-allose(in) + H(+) + phosphate => ATP + D-allose(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60172", "l": "5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate = (2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102801", "l": "anthocyanin 5-O-glucoside-4'''-O-malonyltransferase activity", "d": ["Catalysis of the reaction: 4'''-demalonylsalvianin + malonyl-CoA = salvianin + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465924", "l": "OPN1LW binds 11cRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18069", "l": "L-arginine = D-arginine", "d": []}, {"i": "EC:5.1.1.9", "l": "\"arginine racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64290", "l": "cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23719", "l": "(3Z)-dodecenoyl-CoA <=> (2E)-dodecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814153", "l": "ADO oxidises 2AET to HTAU (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420724", "l": "CASR binds Ca2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694790", "l": "E protein gets N-glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75647", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (8R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700149", "l": "Active ALK binds PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874082", "l": "MET phosphorylates PTK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61148", "l": "myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose = H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806957", "l": "MET receptor dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871265", "l": "YAP1 binds TEAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59146", "l": "5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate => 10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61859", "l": "dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2 <=> betaenone C + 3 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18474", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58659", "l": "a 5'-end (5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine <=> a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45189", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912398", "l": "NOTCH1 binds DNER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443418", "l": "GP1b signaling involves c-Src (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51548", "l": "(R)-tetrahydropapaverine + S-adenosyl-L-methionine = (R)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1236970", "l": "Proteasomal clevage of exogenous antigen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449058", "l": "Interleukin-1 family are secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851988", "l": "BTN2A2 binds T cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730858", "l": "Autophosphorylation of BTK/ITK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32485", "l": "CO2 + methanol + pyropheophorbide a => H(+) + H2O + pheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047250", "l": "4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + UDP-D-glucose = 4-(beta-D-glucosyloxy)benzoate + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67647", "l": "ATP + dZDP <=> ADP + dZTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51907", "l": "10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate <=> 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427514", "l": "eNoSC deacetylates histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31513", "l": "chenodeoxycholate + CoA + H(+) => chenodeoxycholoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15409", "l": "1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine = 1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}, {"i": "EC:2.3.1.147", "l": "\"glycerophospholipid arachidonoyl-transferase (CoA-independent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62111", "l": "an acyl-CoA + sn-glycero-3-phosphoethanolamine <=> a monoacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18888", "l": "GDP-beta-L-fucose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9734730", "l": "ORC1 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368582", "l": "CXXC4 binds DVL to prevent AXIN binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250217", "l": "ARL2:GTP binds ARL2BP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.94", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018852", "l": "dichloromuconate cycloisomerase activity", "d": ["Catalysis of the reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156678", "l": "Activation of Cdc25C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41423", "l": "2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 <=> CO2 + grixazone B + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13054", "l": "L-phenylalanine + pyruvate => 3-phenylpyruvate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21033", "l": "glucuronate acceptor + UDP-alpha-D-glucuronate => acceptor beta-D-glucuronoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29866", "l": "AMP + GTP <=> ADP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40078", "l": "6-amino-6-deoxyfutalosine + H(+) + H2O <=> futalosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70947", "l": "L-tryptophan(in) = L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47594", "l": "CMP + ganglioside GP1c (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004409", "l": "homoaconitate hydratase activity", "d": ["Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75387", "l": "H2O + queuosine 5'-phosphate = D-ribose 5-phosphate + queuine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418850", "l": "Activation of Cdc42 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50063", "l": "ATP + glycochenodeoxycholate(in) + H2O <=> ADP + glycochenodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23389", "l": "ATP + hygromycin B => 7''-O-phosphohygromycin B + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21795", "l": "NADP(+) + propan-2-ol <=> acetone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28934", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate <=> 4-carboxy-2-hydroxy-cis,cis-muconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32856", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033832", "l": "alpha,alpha-trehalose phosphorylase (configuration-retaining) activity", "d": ["Catalysis of the reaction: alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755303", "l": "26S proteasome degrades HIFalpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005260", "l": "intracellularly ATP-gated chloride channel activity", "d": ["Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2471842", "l": "Collagen type XXV ectomain shedding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948136", "l": "ULK1 Translocates to the mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120092", "l": "crotonyl-CoA hydratase activity", "d": ["Catalysis of the reaction: Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine."]}, {"i": "RHEA:45584", "l": "3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25283", "l": "O2 + reduced [NADPH--hemoprotein reductase] + squalene => (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18629", "l": "ATP + NAD(+) = ADP + H(+) + NADP(+)", "d": []}, {"i": "EC:2.7.1.23", "l": "\"NAD(+) kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56236", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297333", "l": "Association of Acrosin Heavy and Light Chain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12160", "l": "2-deoxy-D-gluconate + NAD(+) = 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.125", "l": "\"2-deoxy-D-gluconate 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140068", "l": "histone crotonyltransferase activity", "d": ["Catalysis of the reaction: crotonyl-CoA + histone = CoA + crotonyl-histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27552", "l": "(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate => di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166753", "l": "Conversion of C4 into C4a and C4b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24938", "l": "H2O + imidazol-4-one <=> N-formimidoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21568", "l": "beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O = beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose", "d": []}, {"i": "EC:3.2.1.140", "l": "\"lacto-N-biosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66823", "l": "ATP + H2O + Mn(2+)(in) <=> ADP + H(+) + Mn(2+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034540", "l": "3-monobromobisphenol A reductive dehalogenase activity", "d": ["Catalysis of the reaction: 3-monobromobisphenol A + 2 H+ + 2 e- = bisphenol A + HBr."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102328", "l": "3-oxoacid decarboxylase activity", "d": ["Catalysis of the reaction: H+ + a 3-oxoacid = carbon dioxide + a methylketone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49482", "l": "H(+) + L-2-aminoadipate + NADPH => 2 H2O + L-1-piperideine-6-carboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57075", "l": "3-oxoisoapionate 4-phosphate + H(+) <=> CO2 + L-erythrulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51614", "l": "(R)-malate + 2-oxoglutarate => (R)-2-hydroxyglutarate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71233", "l": "2 Fe(2+)-[Dph3] + H(+) + NAD(+) => 2 Fe(3+)-[Dph3] + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58669", "l": "3-deoxyfructose + NADP(+) => 3-deoxyglucosone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043872", "l": "lysine:cadaverine antiporter activity", "d": ["Catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008813", "l": "chorismate lyase activity", "d": ["Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44289", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29910", "l": "H2O + sn-glycero-3-phospho-(1'-rac-glycerol) <=> glycerol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41579", "l": "dTDP-beta-L-mycarose + erythronolide B <=> 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20042", "l": "3-oxopropanoate + H2O + NADP(+) => 2 H(+) + malonate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169192", "l": "PTP1B dephosphorylates GHR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954117", "l": "E2F6:TFDP1 binds EPC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55087", "l": "(3R)-3-hydroxypentanoyl-CoA + H2O <=> (3R)-3-hydroxypentanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50407", "l": "(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] <=> 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27371", "l": "acetaldehyde + acetyl-CoA + H(+) + NADH => acetoin + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67984", "l": "N-acetyl-L-leucine = N-acetyl-D-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73461", "l": "3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide b => 5 H(+) + 2 O2 + protochlorophyllide a + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043857", "l": "N-acetylornithine carbamoyltransferase activity", "d": ["Catalysis of the reaction: N(2)-acetyl-L-ornithine + carbamoyl phosphate = N(2)-acetyl-L-citrulline + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74573", "l": "N(alpha)-acetyl-L-methionine + N-terminal L-aspartyl-[protein] => H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.240751554780076", "identifiers": [{"i": "GO:0140326", "l": "ATPase-coupled intramembrane lipid transporter activity", "d": ["Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74070", "l": "ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A <=> ADP + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0099530", "l": "G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential", "d": ["A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39865", "l": "1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71763", "l": "2-oxoglutarate(out) + citrate(in) = 2-oxoglutarate(in) + citrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45646", "l": "H(+) + N-hexadecanoylsphing-4-enine + phosphocholine => H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630045", "l": "Defective NTHL1 truncation mutants do not bind dihydrouracil (DHU) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102947", "l": "(+)-delta-cadinene-8-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + (+)-delta-cadinene + NADPH + O2 <=> 8-hydroxy-(+)-delta-cadinene + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754964", "l": "ADA deamidates RBV (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009040", "l": "ureidoglycolate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-ureidoglycolate + NAD(P)+ = oxalureate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730858", "l": "Autophosphorylation of BTK/ITK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372697", "l": "Crk binding to p130cas (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59840", "l": "(6S)-5,6,7,8-tetrahydrofolate + syringate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947499", "l": "Exchange of oxygen with sulfur in MoCo (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69629", "l": "H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693478", "l": "HTR1A binds HTR1A agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25769", "l": "2-oxobutanoate + CO2 => 3-carboxy-2-oxobutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68003", "l": "1,1-dichloroethene + AH2 <=> A + chloride + chloroethene + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202472", "l": "Translocation of TRAF6 to CBM complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166015", "l": "Association of LBP with LPS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004399", "l": "histidinol dehydrogenase activity", "d": ["Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39170", "l": "H(+) + malonyl-CoA + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57798", "l": "4-methylcatechol + NAD(+) + nitrite => 4-nitrotoluene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63962", "l": "abscisate(in) + ADP + H(+) + phosphate => abscisate(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68426", "l": "(3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial => (3R)-3-hydroxy-10'-apo-beta-carotenal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015170", "l": "propanediol transmembrane transporter activity", "d": ["Enables the transfer of propanediol from one side of a membrane to the other. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51383", "l": "(9Z)-octadecenoyl-CoA + dopamine <=> CoA + H(+) + N-(9Z-octadecanoyl)-dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71430", "l": "3,3'-diiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) <=> 3,3'-diiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2197691", "l": "WIP binds WASP,N-WASP, activating them (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035595", "l": "N-acetylglucosaminylinositol deacetylase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate. This reaction is the hydrolysis of an acetyl group from N-acetylglucosaminylinositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8987214", "l": "p-STAT3 dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10810", "l": "(1R,2S)-epoxypropylphosphonate + 2 H2O => (S)-2-hydroxypropylphosphonate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035716", "l": "chemokine (C-C motif) ligand 12 binding", "d": ["Binding to chemokine (C-C motif) ligand 12."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14550", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O => 2-oxopent-4-enoate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54709", "l": "N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32971", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37415", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0048031", "l": "trisaccharide binding", "d": ["Binding to a trisaccharide. Trisaccharides are sugars composed of three monosaccharide units."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47041", "l": "5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] => 5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182594", "l": "Association of INK4 family proteins with CDK4/6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37435", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008750", "l": "NAD(P)+ transhydrogenase (AB-specific) activity", "d": ["Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58214", "l": "dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ajmalicine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29433", "l": "ADP + diphosphate => ATP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20418", "l": "coelenterazine + O2 => CO2 + coelenteramide + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75195", "l": "2-dehydro-3-deoxy-D-arabinonate + NAD(+) = 5-hydroxy-2,4-dioxopentanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17227", "l": "6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2509827", "l": "ITPA hydrolyses ITP to IMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32546", "l": "(2E)-geranyl diphosphate + H2O <=> 1,8-cineole + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40060", "l": "decanoyl-CoA + H2O => CoA + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473596", "l": "Collagen type I degradation by MMP15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030883", "l": "endogenous lipid antigen binding", "d": ["Binding to an endogenous cellular lipid antigen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15915", "l": "ADP + thiamine diphosphate => ATP + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14926", "l": "D-mannitol 1-phosphate + NADP(+) => D-mannose 6-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69067", "l": "N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + O2 <=> H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944214", "l": "Association of procollagen type I (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392834", "l": "Activation of EPACs by cAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29471", "l": "D-ribose 5-phosphate + H2O = D-ribose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60674", "l": "H(+) + NADH + neral => NAD(+) + nerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444661", "l": "HCAR2 binds HCAR2 ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41897", "l": "(2E)-tetradecenoyl-[ACP] + H(+) + NADPH => NADP(+) + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046871", "l": "N-acetylgalactosamine binding", "d": ["Binding to N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, the n-acetyl derivative of galactosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28537", "l": "dTTP + H2O <=> diphosphate + dTMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54616", "l": "2-oxoglutarate + heptadecanoyl-CoA + O2 = 2-hydroxyheptadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12770", "l": "A + D-gluconate => 2-dehydro-D-gluconate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21646", "l": "ADP + H(+) + sn-glycerol 3-phosphate => ATP + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54506", "l": "beta-hexaprene + diphosphate => all-trans-hexaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52119", "l": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA <=> 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20449", "l": "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)", "d": []}, {"i": "EC:1.13.11.36", "l": "\"chloridazon-catechol dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22214", "l": "(2R,3S)-tartrate => (2R,3R)-tartrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71511", "l": "phylloquinone(out) = phylloquinone(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4093327", "l": "EPHA binds TIAM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483077", "l": "PE transports from the mitochondrial membrane to the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38278", "l": "(3R)-citramalyl-CoA <=> acetyl-CoA + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000120", "l": "CBLIF binds RCbl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11744", "l": "H2O + thiamine triphosphate = H(+) + phosphate + thiamine diphosphate", "d": []}, {"i": "EC:3.6.1.28", "l": "\"thiamine-triphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73458", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + salvigenin <=> 8-hydroxysalvigenin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64451", "l": "L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61457", "l": "7-chlorotetracycline + H(+) + NADPH + O2 => (1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607734", "l": "PKC-delta translocates to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29009", "l": "H(+)(out) + Mn(2+)(out) => H(+)(in) + Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18990", "l": "H(+) + L-valine => 2-methylpropan-1-amine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34404", "l": "9-cis-10'-apo-beta-carotenal + 2 O2 => (11R)-carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40921", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72836", "l": "3',3'-cUAMP + H2O => H(+) + U[3'-5']pAp[3']", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16583", "l": "2 Fe(III)-[cytochrome c] + 2 H2O => 2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.3", "l": "\"protoporphyrinogen IX dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982645", "l": "GRKs bind ADRB2:Catecholamine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38916", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013145", "l": "RAC1 binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.1", "l": "\"deoxyribonuclease I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26097", "l": "(4R)-limonene + H(+) + NADPH + O2 = H2O + limonene 1,2-epoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691167", "l": "CUL1, SKP1, FBXL5 bind (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814094", "l": "ARL1:GTP binds ARFIP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034922", "l": "4,5-dihydroxypyrene dioxygenase activity", "d": ["Catalysis of the reaction: 4,5-dihydroxypyrene + O2 = phenanthrene-4,5-dicarboxylate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14387", "l": "a dolichyl phosphate + H(+) + phosphate => a dolichyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16608", "l": "dodecanoyl-CoA + H2O + oxaloacetate <=> (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63150", "l": "(9Z)-octadecenoate + taurine => H2O + N-(9Z-octadecenoyl)-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28722", "l": "adenine(in) + H(+)(in) <=> adenine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29659", "l": "O-acetyl-L-serine(in) = O-acetyl-L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473584", "l": "Collagen type III degradation by MMP15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626235", "l": "HSPA8 dissociates from LAMP2a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4411402", "l": "Activation of NLK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357479", "l": "p-AXL binds PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62593", "l": "(S)-8-oxocitronellyl enol + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24029", "l": "2-oxoglutarate + 4-(trimethylamino)butanoate + O2 => carnitine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39610", "l": "(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH <=> (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30519", "l": "GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine", "d": []}, {"i": "EC:2.7.7.105", "l": "\"phosphoenolpyruvate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0140333", "l": "glycerophospholipid flippase activity", "d": ["Catalysis of the movement of a glycerophospholipid from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56151", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphocholine <=> CoA + hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9620103", "l": "ALDH2 transforms GTN to NO (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50754", "l": "2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O => 2 naphthalene-1,2,4,8-tetrol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59215", "l": "holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP <=> AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112755", "l": "SOCS3 binds IL6ST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39802", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) <=> 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19338", "l": "2 hydroxylamine + 2 NAD(+) => 2 H(+) + hyponitrous acid + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985943", "l": "p-Y701-STAT1 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56847", "l": "nocamycin E + S-adenosyl-L-methionine <=> nocamycin I + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026358", "l": "NTF4 binds NTRK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63953", "l": "a sphingoid 1-phosphate + H2O => a sphingoid base + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75051", "l": "chenodeoxycholate(out) = chenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41920", "l": "3-oxooctadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39144", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) => 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71393", "l": "16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in) => 16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797554", "l": "ABP1 binds SHANK proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53444", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61583", "l": "(3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+) <=> (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33026", "l": "6-phospho-D-gluconate + NAD(+) <=> CO2 + D-ribulose 5-phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53925", "l": "a secondary amine + S-adenosyl-L-methionine => a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32444", "l": "all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868658", "l": "1,4-alpha-glucan is converted to glucanotrehalose (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12829", "l": "(2S,3S)-3-methyl-L-aspartate = mesaconate + NH4(+)", "d": []}, {"i": "EC:4.3.1.2", "l": "\"methylaspartate ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807585", "l": "BPI binds LPS on the bacterial surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11501", "l": "3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O => 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004362", "l": "glutathione-disulfide reductase (NADP) activity", "d": ["Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9818937", "l": "MEN1 binds MLL1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0070576", "l": "vitamin D 24-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-24 of any form of vitamin D."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49545", "l": "(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O => 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69263", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate <=> (3R)-3-hydroxy-3-(thiiran-2-yl)propanenitrile + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16585", "l": "[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:2.8.1.8", "l": "\"lipoyl synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624951", "l": "TNPO1 binds KIF17 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72180", "l": "2 Na(+)(out) + tauro-beta-muricholate(out) => 2 Na(+)(in) + tauro-beta-muricholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52545", "l": "D-erythronate + NAD(+) => 2-dehydro-D-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30925", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+) => (R)-glycerate + ADP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60905", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => 13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42865", "l": "norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + norspermine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352946", "l": "fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + glyceraldehyde 3-phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418456", "l": "cGMP is degraded by PDEs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159733", "l": "Furin cleaves pro-factor X to factor X (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9726509", "l": "NR3C2 binds fludrocortisone (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873926", "l": "IFNG dimer binds IFNGR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10318", "l": "5-hydroxymethyluracil + CO2 + succinate => 2-oxoglutarate + O2 + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47844", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606789", "l": "ARSB hydrolyses DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103055", "l": "gibberelli A15, 2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A15 + 2-oxoglutarate + O2 <=> gibberellin A24 + succinate + carbon dioxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61730", "l": "a 3-dehydro-D-glucoside => a 3-dehydro-D-guloside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20992", "l": "16-hydroxytabersonine + S-adenosyl-L-methionine = 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.94", "l": "\"tabersonine 16-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63581", "l": "20-hydroxyecdysone 22-phosphate + H2O => 20-hydroxyecdysone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14995", "l": "a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+) => acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47826", "l": "3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + malonyl-[ACP] + octadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62256", "l": "Cd(2+)(out) + 2 hydrogencarbonate(out) = Cd(2+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432483", "l": "SLMB binds phosphorylated nuclear PER, facilitating its ubiquitination (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29636", "l": "D-maltopentaose + H2O => alpha-D-glucose + D-maltotetraose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9028730", "l": "Activated NTRK2 binds FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102710", "l": "D-inositol-3-phosphate glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + 1D-myo-inositol 3-phosphate = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043716", "l": "2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate is also known as HK-MTPenyl-P, and 1,2-dihydroxy-3-keto-5-methylthiopentene as DHK-MTPene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618811", "l": "Calcium binds calmodulin at the synapse (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72756", "l": "3 ATP => 3',3',3'-c-tri-AMP + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876497", "l": "InlA binds CDH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.87", "l": "\"ADAMTS13 endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75176", "l": "dATP + NAD(+) => dADP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112435", "l": "Formation of Elongin BC complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57173", "l": "(S)-2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5221061", "l": "TDG excises 5-carboxylcytosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10295", "l": "acetyl-CoA + D-glucosamine 6-phosphate <=> CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29994", "l": "H(+)(in) + L-lyxopyranose(in) <=> H(+)(out) + L-lyxopyranose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59357", "l": "H2O + lactobiono-1,5-lactone => H(+) + lactobionate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102468", "l": "wogonin 7-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate + wogonin <=> UDP + wogonin 7-O-beta-D-glucuronate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174171", "l": "Association of Cyclin A with the APC/C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36250", "l": "(E)-anol + S-adenosyl-L-methionine <=> (E)-anethole + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.99.-", "l": "\"Transferring other nitrogenous groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72164", "l": "chloride(out) + 2 Na(+)(out) + O-butanoyl-(R)-carnitine(out) => chloride(in) + 2 Na(+)(in) + O-butanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32214", "l": "(Z)-5-oxohex-2-enedioate <=> (2E,4Z)-2-hydroxyhexa-2,4-dienedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102140", "l": "heparan sulfate N-deacetylase activity", "d": ["Catalysis of the reaction: H2O + [heparan sulfate]-N-acetyl-alpha-D-glucosamine = acetate + H+ + [heparan sulfate]-alpha-D-glucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36848", "l": "FAD + L-threonyl-[protein] => AMP + FMN-L-threonyl-[protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015608", "l": "carbohydrate-importing ABC transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(out) -> ADP + phosphate + carbohydrate(in)."]}, {"i": "TCDB:3.A.1.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20103", "l": "AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein] => a long-chain fatty acid + ATP + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956652", "l": "ITCH gene expression is stimulated by RUNX1 and YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36990", "l": "CMP + phosphate <=> alpha-D-ribose 1,5-bisphosphate + cytosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63471", "l": "all-trans-octaprenol + ATP <=> ADP + all-trans-octaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26318", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate => 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177284", "l": "PKA phosphorylates PDE4B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59290", "l": "D-glucose + sphing-4-enine => beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63687", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP <=> (4R,5S)-dethiobiotin + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878654", "l": "ACP6 hydrolyses MYS-LPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199112", "l": "CRTAM binds to NECL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.194", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202222", "l": "Phosphorylation of PKC theta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797974", "l": "LRRTMs bind NRXNs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693575", "l": "DNA-PKcs autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0005385", "l": "zinc ion transmembrane transporter activity", "d": ["Enables the transfer of zinc (Zn) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25198", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O => 5-amino-6-(D-ribitylamino)uracil + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9650473", "l": "SERPING1 is secreted (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40551", "l": "demethylphylloquinol + S-adenosyl-L-methionine = H(+) + phylloquinol + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.329", "l": "\"demethylphylloquinol methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160874", "l": "HYAL1 hydrolyses (HA)50 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382055", "l": "Grb7 binds to the active PDGF receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781814", "l": "USP19 deubiquitinates RNF123 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928619", "l": "PAK1 binds RAC1:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68582", "l": "ADP + H(+) + L-kynurenine(in) + phosphate => ATP + H2O + L-kynurenine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14380", "l": "(3R)-3-hydroxy-L-aspartate <=> glycine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32000", "l": "(2E,6E)-farnesyl diphosphate => bicyclogermacrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74105", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437230", "l": "L1-FGFR cis-heterodimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939204", "l": "ESTG binds ESR1:chaperone complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9619756", "l": "NR1H2 binds ABCA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28545", "l": "fluoroacetyl-CoA + H2O <=> CoA + fluoroacetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72064", "l": "glycoursodeoxycholate(out) + 2 Na(+)(out) => glycoursodeoxycholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56072", "l": "a 2-acylphloroglucinol + UDP-alpha-D-glucose = a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP", "d": []}, {"i": "EC:2.4.1.358", "l": "\"acylphloroglucinol glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810894", "l": "Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626962", "l": "SIRT1 deacetylates FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64379", "l": "8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid <=> a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59387", "l": "2-oxoglutarate + 4-amino-L-phenylalanine <=> 3-(4-aminophenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68604", "l": "(2S)-3-sulfopropanediol = H(+) + hydroxyacetone + sulfite", "d": []}, {"i": "EC:4.4.1.41", "l": "\"(2S)-3-sulfopropanediol sulfolyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33680", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001048", "l": "RNA polymerase IV core binding", "d": ["Binding to RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35652", "l": "(4R)-hydroxysphinganine + a fatty acyl-CoA => an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24462", "l": "acetyl-[ACP] + CO2 => H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168878", "l": "PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613648", "l": "SOX10 dimer binds the POU3F1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11176", "l": "kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose", "d": []}, {"i": "EC:2.4.1.230", "l": "\"kojibiose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59703", "l": "D-cellopentaono-1,5-lactone + H2O <=> D-cellopentaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972960", "l": "POU5F1 (OCT4), SOX2, NANOG bind the FGF2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183055", "l": "Binding of CBL to EGFR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.180", "l": "\"brassinolide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205231", "l": "Dimerization of KIT upon SCF binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70290", "l": "1D-myo-inositol 3,4,6-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19195", "l": "AH2 + all-trans-retinol => A + all-trans-13,14-dihydroretinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31637", "l": "5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc => beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13935", "l": "all-trans-retinol + H(+) + hexadecanoate => all-trans-retinyl hexadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050019", "l": "L-arabinitol 4-dehydrogenase activity", "d": ["Catalysis of the reaction: L-arabinitol + NAD+ = L-xylulose + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66033", "l": "alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612593", "l": "ERBB4 binds DLG4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607747", "l": "TRAF6 binds MALT1 oligomers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961934", "l": "CDK1 gene expression is stimulated by E2F1 and repressed by RBL1 and RBL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29370", "l": "CMP + H2O <=> cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17005", "l": "ATP + D-glucuronate = 1-phospho-alpha-D-glucuronate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.43", "l": "\"glucuronokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66843", "l": "asperterpenoid A + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> asperterpenoid B + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37122", "l": "7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine <=> 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089719", "l": "RHG protein domain binding", "d": ["Binding to an RHG (reaper/hid/grimm) domain/motif (AKA iap binding motif)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36319", "l": "2 H(+) + 2 NADPH + octadecanoyl-CoA = CoA + 2 NADP(+) + octadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37779", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13751", "l": "a ribonucleoside 5'-diphosphate + ADP => a ribonucleoside 5'-triphosphate + AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13508", "l": "choline + O2 <=> betaine aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61879", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52924", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17721", "l": "a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.8", "l": "\"long-chain-acyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.9", "l": "\"(R)-2-hydroxyacyl-CoA dehydratase activating ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11291", "l": "dihydromacarpine + H(+) + O2 <=> H2O2 + macarpine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940134", "l": "FOLR2 binds FOLA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64049", "l": "(13Z)-docosenoyl-CoA + sphinganine => CoA + H(+) + N-(13Z-docosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050226", "l": "psychosine sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72109", "l": "Na(+)(in) + O-acyl-(R)-carnitine(in) => Na(+)(out) + O-acyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018772", "l": "trioxoheptanoate hydrolase activity", "d": ["Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67627", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.30", "l": "\"NAD(+) ADP-ribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31390", "l": "(S)-2,3-epoxysqualene <=> alpha-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422454", "l": "Polysialylation of NCAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15509", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}, {"i": "EC:2.4.1.144", "l": "\"beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32790", "l": "ATP + H2O + L-ectoine(out) <=> ADP + H(+) + L-ectoine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649108", "l": "HTR3A pentamer binds 5HT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24712", "l": "L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose => 2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61280", "l": "4-aminobutanoate + H2O + O2 = H2O2 + NH4(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14636", "l": "ATP + H2O + Na(+)(in) <=> ADP + H(+) + Na(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43807", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22844", "l": "(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888577", "l": "Synthesis of GABA by GAD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66041", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627350", "l": "SMAC (DIABLO) binds XIAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46522", "l": "an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O => an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473596", "l": "Collagen type I degradation by MMP15 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706319", "l": "Active FLT3 binds to SLA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60389", "l": "Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70867", "l": "L-alanine(out) + L-glutamine(in) + Na(+)(out) = L-alanine(in) + L-glutamine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686335", "l": "CSF2RA:CSF2RB binds SFTPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26117", "l": "diphosphate + epi-cedrol => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296301", "l": "CCRL2 binds CCL19 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8865605", "l": "BRWD1 binds SMARCA4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63111", "l": "16-hydroxy-ilicicolin A epoxide <=> ascofuranol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350598", "l": "Arginine<=>Agmatine+CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13558", "l": "ATP + gamma-L-glutamyl-L-cysteine + glycine => ADP + glutathione + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5195402", "l": "CDK1 phosphorylates LPIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0043548", "l": "phosphatidylinositol 3-kinase binding", "d": ["Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56007", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12133", "l": "ATP + Cd(2+)(in) + H2O => ADP + Cd(2+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2529020", "l": "CK2 phosphorylates condensin I subunits (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373748", "l": "SEMA4D interacts with CD72 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3204303", "l": "MRE11 binds cytosolic DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70481", "l": "TPI1 isomerizes GA3P to DHAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428750", "l": "Gq activation by TP receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40010", "l": "(+)-copalyl diphosphate + H2O <=> (+)-copalol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13620", "l": "H2O + S-methyl-5'-thioadenosine <=> 5-(methylsulfanyl)-D-ribose + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875817", "l": "MET phosphorylates STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013361", "l": "NEXT3 is cleaved to produce NICD3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9659611", "l": "ANO1 inhibitors bind ANO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0070379", "l": "high mobility group box 1 binding", "d": ["Binding to high mobility group box 1 (HMBGB1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664850", "l": "ATM binds PEX5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68692", "l": "3'-phosphoadenylyl sulfate + 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(beta-D-glucuronate) = 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129375", "l": "Elastin cross-linking by lysyl oxidase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38595", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64388", "l": "4 A + sn-3-O-phytanylglycerol 1-phosphate = 4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212222", "l": "PRC2 recruits DNA methyltransferases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72957", "l": "2 Na(+)(in) + nicotinate(in) => 2 Na(+)(out) + nicotinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839095", "l": "p-BCR-pFGFR1 binds GRB2:GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682983", "l": "ATM phosphorylates WHSC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416929", "l": "PTGFR binds PGF2a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.622337805354121", "identifiers": [{"i": "GO:0036094", "l": "small molecule binding", "d": ["Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46712", "l": "pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49924", "l": "(R)-carnitine(out) + O-acyl-(R)-carnitine(in) = (R)-carnitine(in) + O-acyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592371", "l": "Initial activation of proMMP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635845", "l": "GLI proteins bind CDC73 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23994", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA => 1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54146", "l": "5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate => 2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050455", "l": "columbamine oxidase activity", "d": ["Catalysis of the reaction: 2 columbamine + O2 = 2 berberine + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757688", "l": "SERPINA6 binds PREDN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21164", "l": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+)", "d": []}, {"i": "EC:3.1.1.1", "l": "\"carboxylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051059", "l": "NF-kappaB binding", "d": ["Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14688", "l": "A + a primary alcohol <=> AH2 + an aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33456", "l": "4alpha-carboxyzymosterol + NADP(+) => CO2 + NADPH + zymosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29429", "l": "(R)-carnitine(in) + 4-(trimethylamino)butanoate(out) => (R)-carnitine(out) + 4-(trimethylamino)butanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46306", "l": "16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29757", "l": "(R)-lipoate(out) => (R)-lipoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848776", "l": "PTK6 phosphorylates DOK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57180", "l": "L-lysyl-[protein] + methylglyoxal = N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112271", "l": "The receptor:G-protein complex dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381290", "l": "PPARG:RXRA heterodimer binds to PPARG corepressors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66166", "l": "CoA + H(+) + N-butanoylserotonin => butanoyl-CoA + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41128", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28112", "l": "5'-chloro-5'-deoxyadenosine + L-methionine => chloride + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75478", "l": "D-mannose(out) + n Na(+)(out) <=> D-mannose(in) + n Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693198", "l": "RHOD binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43974", "l": "H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445072", "l": "Interaction of PAK1 with Rac1-GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018490", "l": "4-hydroxyphenylpyruvate oxidase activity", "d": ["Catalysis of the reaction: 2 (4-hydroxyphenyl)pyruvate + O2 = 2 (4-hydroxyphenyl)acetate + 2 CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050534", "l": "3-deoxyoctulosonase activity", "d": ["Catalysis of the reaction: 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63310", "l": "11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33186", "l": "citrate(in) <=> citrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54364", "l": "2 acetaldehyde = acetoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42495", "l": "3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 <=> 3'-N-debenzoyltaxol + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70885", "l": "H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in) => H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31331", "l": "ATP + H(+) + molybdopterin = adenylyl-molybdopterin + diphosphate", "d": []}, {"i": "EC:2.7.7.75", "l": "\"molybdopterin adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42992", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (R)-nephthenol + diphosphate", "d": []}, {"i": "EC:4.2.3.149", "l": "\"nephthenol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34833", "l": "N-acyl-15-methylhexadecasphing-4-enine + phosphate => H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2059926", "l": "NPHP4 protein binds LATS proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635845", "l": "GLI proteins bind CDC73 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689861", "l": "Recruitment of XPA and release of CAK  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69823", "l": "(22S)-22-hydroxycampest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] = (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29771", "l": "arsenate(in) + ATP + H2O = ADP + arsenate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25612", "l": "beta-D-allofuranose <=> beta-D-allopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140164", "l": "Golgi transport complex binding", "d": ["Binding to a Golgi transport complex, a multisubunit tethering complex of the CATCHR family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0016843", "l": "amine-lyase activity", "d": ["Catalysis of the release of amines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate."]}, {"i": "EC:4.3.3.-", "l": "\"Amine-lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939066", "l": "PRKCB gene expression is stimulated by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029451", "l": "Activation of RAC1 by VAV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730835", "l": "Autophosphorylation of PKC-theta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52560", "l": "2-dehydro-D-erythronate = 3-dehydro-D-erythronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16720", "l": "deoxycholate + FAD + H(+) + H2O <=> cholate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32074", "l": "geranylgeranyl diphosphate <=> (13E)-labda-7,13-dien-15-yl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58960", "l": "benzaldehyde + H2O + O2 = benzoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047807", "l": "cytokinin 7-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-7-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664879", "l": "ATM:PEX5 binds ATM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417843", "l": "P2Y13 binds ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873921", "l": "Binding of STAT1 to p-IFNGR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193097", "l": "Pregnenolone translocates from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9653514", "l": "USP17L2 deubiquitinates RCE1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810724", "l": "PI3 binds the bacterial surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-990478", "l": "Kinesin-14 is a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72177", "l": "5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out) => 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72611", "l": "H(+)(out) + L-alanyl-L-lysine(out) = H(+)(in) + L-alanyl-L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034511", "l": "U3 snoRNA binding", "d": ["Binding to a U3 small nucleolar RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22550", "l": "(S)-2-amino-6-oxohexanoate + H2O2 + NH4(+) => H2O + L-lysine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417825", "l": "P2Y11 receptor can bind to ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51594", "l": "benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662466", "l": "XYLB phosphorylates D-xylulose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37414", "l": "aklavinone + NADP(+) <=> aklaviketone + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54818", "l": "[protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+) => L-glutaminyl-[protein] + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202510", "l": "Activation of TAK1-TAB2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37669", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69467", "l": "2 [thioredoxin]-dithiol + arsenic triglutathione + H2O + 2 S-adenosyl-L-methionine <=> 2 [thioredoxin]-disulfide + dimethylarsinous acid + 3 glutathione + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005124", "l": "scavenger receptor binding", "d": ["Binding to scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75680", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26533", "l": "4-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68032", "l": "(S)-cystathionine ketimine + 2 H(+) + NADH = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46076", "l": "(2E)-eicosenoyl-CoA + H(+) + NADH = eicosanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55566", "l": "4-hydoxytryptamine 4-phosphate + ADP + H(+) => 4-hydroxytryptamine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21389", "l": "H2O + L-2-aminohexano-6-lactam => L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696564", "l": "USP25 deubiquitinates DDX58 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102099", "l": "FAD-dependent urate hydroxylase activity", "d": ["Catalysis of the reaction: 7,9-dihydro-1H-purine-2,6,8(3H)-trione + NADH + H+ + O2 <=> 5-hydroxyisouric acid + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21998", "l": "a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA => a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40590", "l": "H2O + octanedioyl-CoA <=> CoA + H(+) + octanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210282", "l": "Interaction of GPVI and FceRI gamma (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63042", "l": "H(+) + lovastatin carboxylate => H2O + lovastatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786421", "l": "CHIA hydrolyses chitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45797", "l": "(3R)-3-hydroxybutanoyl-CoA + NADP(+) => acetoacetyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71243", "l": "chloride(out) + hypotaurine(out) + 2 Na(+)(out) = chloride(in) + hypotaurine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55306", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018705", "l": "1,2-dichloroethene reductive dehalogenase activity", "d": ["Catalysis of the reaction: 1,2-dichloroethene + 2 H+ + 2 e- = HCl + vinyl chloride."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604712", "l": "Initial activation of proMMP7 by trypsin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11769", "l": "diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate => 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60839", "l": "a 5'-end diphospho-adenosine in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050449", "l": "casbene synthase activity", "d": ["Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = casbene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797803", "l": "PTPRD binds SLITRK1-6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73162", "l": "FMN(out) + NAD(+)(in) <=> FMN(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46726", "l": "(2R)-2-methyltetradecanoyl-CoA => (2S)-2-methyltetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56423", "l": "apo-[D-alanyl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16492", "l": "(R)-prunasin + H2O <=> D-glucose + mandelonitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61495", "l": "a sphingoid base + an ultra-long-chain fatty acyl-CoA <=> an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19882", "l": "GTP + L-lysyl-[protein] => diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57956", "l": "dimethyl sulfoxide + H(+) + NADH + O2 = dimethyl sulfone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26291", "l": "2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate => 2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132060", "l": "Formation of C5b:C6:C7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58928", "l": "(3R,4R)-7,2',4'-trihydroxyisoflavanol = (6aR,11aR)-3,9-dihydroxypterocarpan + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21717", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0038181", "l": "bile acid receptor activity", "d": ["Combining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73477", "l": "D-arginine(out) + L-ornithine(in) => D-arginine(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21441", "l": "a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 => a long-chain alkane + formate + H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23896", "l": "5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate", "d": []}, {"i": "EC:5.3.1.17", "l": "\"5-dehydro-4-deoxy-D-glucuronate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51651", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + O2 <=> (S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980118", "l": "ARRB mediates NOTCH1 ubiquitination (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9016916", "l": "NOTCH3 coactivator complex binds the PTCRA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050240", "l": "pyrogallol 1,2-oxygenase activity", "d": ["Catalysis of the reaction: O2 + pyrogallol = (Z)-5-oxohex-2-enedioate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63199", "l": "(10bR,4aS)-noroxomaritidine + H(+) + NADPH <=> (10bR,4aS)-oxomaritidine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50833", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 => 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67471", "l": "H2O + malonyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.128", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000319", "l": "BORA binds PLK1 and AURKA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44274", "l": "4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912629", "l": "CBL is tyrosine phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64445", "l": "L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788974", "l": "Hypochlorous acid and nitrite react to nitryl chloride (NO2Cl) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15362", "l": "a dolichyl phosphate + UDP-alpha-D-xylose => a dolichyl D-xylosyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30562", "l": "GTP + H2O <=> guanosine + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17953", "l": "3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde", "d": []}, {"i": "EC:1.13.11.6", "l": "\"3-hydroxyanthranilate 3,4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692880", "l": "HRH3 binds Hist (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31136", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate => 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625426", "l": "Retrograde IFT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870469", "l": "RGGT geranylgeranylates RAB proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033490", "l": "TYSND1 cleaves PHYH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39576", "l": "3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32923", "l": "H2O + sn-glycero-3-phospho-(1'-sn-glycerol) = glycerol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13638", "l": "H(+) + methane + NADH + O2 => H2O + methanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19156", "l": "apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose <=> 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814096", "l": "ARL1:GTP binds SCOC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45612", "l": "H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696266", "l": "RND2 binds effectors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47197", "l": "a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71877", "l": "2 Na(+)(in) + taurocholate(in) => 2 Na(+)(out) + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033427", "l": "CAA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CAA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43716", "l": "[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP", "d": []}, {"i": "EC:2.7.7.89", "l": "\"[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.-", "l": "\"Exodeoxyribonucleases producing 5'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112271", "l": "The receptor:G-protein complex dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24686", "l": "H2O + N-formylmethanofuran = formate + methanofuran", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623341", "l": "p-S133 CREB1 dimer binds the CCND1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26249", "l": "H(+) + levopimaradienol + NADPH + O2 = 2 H2O + levopimaradienal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54758", "l": "AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide => deamido-NAD(+) + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30940", "l": "ATP + dIDP => ADP + dITP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37577", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71164", "l": "homogentisate + O2 => maleylacetoacetate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849797", "l": "Membrane proteases cleave Profilaggrin producing Filaggrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14408", "l": "D-glucose + NADP(+) <=> D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63405", "l": "3,6-dichloropyridine-2,5-diol + FADH2 + O2 => 6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45608", "l": "H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67043", "l": "(3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + H(+) <=> asnovolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54811", "l": "H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2 <=> H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40199", "l": "hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.-", "l": "\"Ether hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66974", "l": "alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.706056554619465", "identifiers": [{"i": "GO:0033293", "l": "monocarboxylic acid binding", "d": ["Binding to a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130194", "l": "ABL phosphorylates WAVEs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102351", "l": "gamma-aminobutyrate transaminase (glyoxylate dependent) activity", "d": ["Catalysis of the reaction: gamma-aminobutyric acid + 2-oxo monocarboxylic acid anion = 4-oxobutanoate + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46078", "l": "eicosanoyl-CoA + NAD(+) => (2E)-eicosenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748991", "l": "XDH oxidises 6MP to 6TU (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167415", "l": "G-protein alpha subunit is inactivated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26212", "l": "L-allo-threonine <=> acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55681", "l": "(2S)-2-amino-4-deoxychorismate => anthranilate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12750", "l": "3,4,5-trihydroxybenzoate + H(+) => 1,2,3-trihydroxybenzene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31852", "l": "(S)-2,3-epoxysqualene => parkeol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694428", "l": "LMAN family proteins bind glycosylated cargo (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48984", "l": "(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + glyoxylate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102086", "l": "N-vanillate-L-glutamate synthetase activity", "d": ["Catalysis of the reaction: vanillate + L-glutamate(1-) + ATP <=> H+ + N-vanillate-L-glutamate + AMP + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75263", "l": "isovitexin + O2 = 3'-dehydroisovitexin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45862", "l": "4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70384", "l": "3-oxosphinganine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75205", "l": "ADP + alpha,alpha-trehalose(in) + H(+) + phosphate => alpha,alpha-trehalose(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40998", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA <=> 4-hydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39449", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+) => (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19780", "l": "A + L-pipecolate <=> AH2 + H(+) + L-1-piperideine-6-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40971", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164832", "l": "ATPase synthesizes ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662613", "l": "MT3 exchanges zinc for copper (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0005048", "l": "signal sequence binding", "d": ["Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56580", "l": "6-thioguanine + S-adenosyl-L-methionine = 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34400", "l": "9-cis-beta-carotene + O2 => 9-cis-10'-apo-beta-carotenal + beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17995", "l": "ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate => ATP + beta-alanine + gamma-L-glutamyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24591", "l": "ATP + D-arabinose <=> ADP + D-arabinose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18141", "l": "NAD(+) + trans-cyclohexane-1,2-diol = 2-hydroxycyclohexan-1-one + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.174", "l": "\"cyclohexane-1,2-diol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58067", "l": "O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin <=> 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40504", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21898", "l": "adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate => (R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68618", "l": "cortisol + NADP(+) => cortisone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9639286", "l": "RRAGC,D exchanges GTP for GDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48595", "l": "a quinone + formate + H(+) <=> a quinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11676", "l": "D-ribose + H2O + NADP(+) = D-ribonate + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.115", "l": "\"ribose 1-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43016", "l": "an S-alkyl-L-cysteine = 2-aminoprop-2-enoate + an alkyl thiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0046790", "l": "virion binding", "d": ["Binding to a virion, either by binding to components of the capsid or the viral envelope."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71925", "l": "2 Na(+)(in) + taurochenodeoxycholate(in) => 2 Na(+)(out) + taurochenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735497", "l": "TBX5 and KAT5 bind the SRF gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56030", "l": "3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => 3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46638", "l": "H(+) + NADPH + testosterone => 5beta-dihydrotestosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13582", "l": "N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74251", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36595", "l": "hydrogen sulfide + NADP(+) = NADPH + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62145", "l": "dGMP + dGTP => 2 dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60080", "l": "4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 = 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050508", "l": "glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16991", "l": "1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47461", "l": "3-oxo-(5Z-tetradecenoyl)-CoA + CoA => (3Z)-dodecenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.59", "l": "\"5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15053", "l": "(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}, {"i": "EC:2.1.2.2", "l": "\"phosphoribosylglycinamide formyltransferase 1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1013020", "l": "Activation of GIRK/Kir3 Channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73705", "l": "UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-glucosamine(out) => UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-glucosamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24966", "l": "calcitetrol + H2O + 2 oxidized [adrenodoxin] => calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71384", "l": "L-asparagine(in) + Na(+)(in) => L-asparagine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49354", "l": "2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69005", "l": "Cdc6 protein is phosphorylated by CDK (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64677", "l": "3-(methylsulfanyl)propanoyl-CoA + butan-1-ol => butyl 3-(methylsulfanyl)propanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34896", "l": "ATP + H2O + selenite(out) => ADP + H(+) + phosphate + selenite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73071", "l": "apigenin + S-adenosyl-L-methionine = genkwanin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53887", "l": "CDP-alpha-D-glucose + D-glucose 6-phosphate <=> alpha,alpha-trehalose 6-phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62246", "l": "a cytidine-thymine dinucleotide in DNA => a cytidine(6-4)thymidine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799431", "l": "TP53 binds HIPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14984", "l": "NADP(+) + testosterone <=> androst-4-ene-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38482", "l": "N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine <=> H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55821", "l": "a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796691", "l": "SPATA2 links CYLD to LUBAC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49278", "l": "CDP + phytyl diphosphate => CTP + phytyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50242", "l": "n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O => [hyaluronan](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051980", "l": "iron-nicotianamine transmembrane transporter activity", "d": ["Enables the transfer of the iron chelate iron-nicotianamine (Fe-NA) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38299", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12230", "l": "AMP + diphosphate + H(+) + L-asparagine + L-glutamate => ATP + H2O + L-aspartate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.-", "l": "\"Site specific endodeoxyribonucleases: cleavage is not sequence specific\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18618", "l": "ATP + oxaloacetate => ADP + CO2 + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951977", "l": "Acetylated RUNX3 binds to BRD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61541", "l": "ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43604", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]", "d": []}, {"i": "EC:1.17.7.3", "l": "\"(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63872", "l": "2-oxoglutarate + L-isoleucine + O2 = 3(1)-hydroxy-L-isoleucine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.74", "l": "\"L-isoleucine 3(1)-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52104", "l": "a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23830", "l": "2,5-didehydro-D-gluconate + H(+) + NADPH => 2-dehydro-D-gluconate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30995", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34413", "l": "cannabidiolate + H2O2 => cannabigerolate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64292", "l": "3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH = (3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38754", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418845", "l": "Activation of caspase-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8934465", "l": "SHC1 binds PTPN12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64432", "l": "H(+)(out) + L-alanyl-L-prolylglycine(out) = H(+)(in) + L-alanyl-L-prolylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58524", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH = (16S)-deshydroxymethyl-stemmadenine + formate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688797", "l": "ATXN3 family cleave Ub chains (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45871", "l": "9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160046", "l": "oxalate:chloride antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(out) + oxalate(in) = chloride(in) + oxalate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16928", "l": "(E)-caffeoyl-CoA + S-adenosyl-L-methionine <=> (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32610", "l": "(6E)-8-hydroxygeraniol + NADP(+) <=> (6E)-8-hydroxygeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451377", "l": "Interaction of IQGAP1 with nephrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389083", "l": "Autophosphorylation of PDGF alpha receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63995", "l": "5-fluorocytidine + ATP <=> 5-fluorocytidine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.3.-", "l": "\"Hydron translocation linked to the hydrolysis of diphosphate\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047311", "l": "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity", "d": ["Catalysis of the reaction: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46229", "l": "apo-[peptidyl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0106345", "l": "glyoxylate reductase activity", "d": ["Catalysis of the reaction: glycolate + NAD(P)+ = glyoxylate + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71943", "l": "(S)-malate(out) + 3 Na(+)(out) = (S)-malate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993790", "l": "Transfer of SUMO2 from E1 to UBE2I (UBC9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801101", "l": "RABGGTA binds RABGGTB (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55871", "l": "(S)-lactate + O2 <=> H2O2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15978", "l": "(S)-4-hydroxymandelonitrile => 4-hydroxybenzaldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877281", "l": "PIAS1 binds p-STAT1 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398040", "l": "Gbeta:gamma activation of PLC beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61839", "l": "ergosterol + UDP-alpha-D-glucose <=> ergosteryl 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54703", "l": "4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] <=> 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40408", "l": "1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050056", "l": "linalool 8-monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + linalool + O2 = (2E)-2,6-dimethylocta-2,7-diene-1,6-diol + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29688", "l": "alpha-maltoheptaose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltohexaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2981040", "l": "COLEC12:ligand is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187828", "l": "Translocation of p21 to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3223200", "l": "Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12415", "l": "(2R)-3-phosphoglycerate + H2O <=> (R)-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55550", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30817", "l": "beta-nicotinamide D-riboside + phosphate => beta-nicotinamide D-ribonucleotide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56482", "l": "(3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672948", "l": "MARK3 phosphorylates KSR1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75098", "l": "2 chloride(in) + oxalate(out) <=> 2 chloride(out) + oxalate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848804", "l": "HIF1A,EPAS1 promote PTK6 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31510", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine <=> H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086081", "l": "cell adhesive protein binding involved in atrial cardiac muscle cell-AV node cell communication", "d": ["Binding to a protein or protein complex that results in the connection of an atrial cardiomyocyte with an AV node cell and contributes to the communication between the two cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19236", "l": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] <=> H(+) + hexadecanoate + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49413", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose => alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018754", "l": "GDIs bind RHOH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47230", "l": "(2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein] => docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27343", "l": "A + H(+) + H2O + hydroxylamine => AH2 + NH4(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534388", "l": "Progesterone Activation Of CatSper (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29570", "l": "2 chloride(in) + H(+)(out) <=> 2 chloride(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9015111", "l": "Factor Xa inhibitors binds Xa (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51046", "l": "CO2 + NH4(+) + protodeoxyviolaceinate => indole-3-pyruvate imine dimer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74792", "l": "(R)-salsolinol(in) => (R)-salsolinol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852317", "l": "PLK1 phosphorylates GTSE1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20927", "l": "a [peptide]-C-terminal (2S)-2-hydroxyglycine <=> a [peptide]-C-terminal amide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51897", "l": "H2O + N(1)-acetylspermine => acetate + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65150", "l": "H(+) + trilobatin + UDP => phloretin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864595", "l": "TFAP2B homodimer binds YEATS4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19620", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74405", "l": "2 (S)-lactate(out) + prostaglandin D2(in) => 2 (S)-lactate(in) + prostaglandin D2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38932", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72123", "l": "Na(+)(out) + O-butanoyl-(R)-carnitine(out) = Na(+)(in) + O-butanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18633", "l": "2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate", "d": []}, {"i": "EC:6.3.5.5", "l": "\"carbamoyl-phosphate synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54633", "l": "2-oxoglutarate + O2 + tetradecanoyl-CoA => 2-hydroxytetradecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18442", "l": "D-dopachrome + H(+) => 5,6-dihydroxyindole + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852337", "l": "GTSE1 binds TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975594", "l": "PLB1 hydrolyses RPALM to atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65753", "l": "2-oxoglutarate + L-glutamate + O2 => (3R)-3-hydroxy-L-glutamate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48660", "l": "8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38682", "l": "ATP + H2O + sphinganine(in) <=> ADP + H(+) + phosphate + sphinganine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12249", "l": "NADP(+) + UDP-N-acetyl-alpha-D-muramate => H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696822", "l": "AKR1B15 reduces EST17b to E1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36816", "l": "dTDP-alpha-D-fucose => dTDP-alpha-D-fucofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28684", "l": "L-aspartate + ubiquinone-8 => iminosuccinate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64011", "l": "(4R)-hydroxysphinganine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008054", "l": "IL1F10 binds IL1RAPL1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10899", "l": "2 H2O + limonin <=> 2 H(+) + limonoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995376", "l": "BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58158", "l": "ADP + H(+) + 4 Na(+)(out) + phosphate => ATP + H2O + 4 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73293", "l": "H(+)(in) + L-valine(out) => H(+)(out) + L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877902", "l": "Activated AR binds RUNX2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53070", "l": "4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-methoxyestrone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749977", "l": "UGT1A6 glucuronates ST (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33526", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O <=> acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170986", "l": "Ral-GDS binds to Ras-GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65891", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine <=> 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.938643630768524", "identifiers": [{"i": "GO:0016779", "l": "nucleotidyltransferase activity", "d": ["Catalysis of the transfer of a nucleotidyl group to a reactant."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008822", "l": "PPM1D dephosphorylates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45764", "l": "H2O + L-aspartate 4-semialdehyde + NAD(+) = 2 H(+) + L-aspartate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65774", "l": "1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43883", "l": "(25S)-3beta-hydroxy-5-cholestenoate + ATP + CoA <=> (25S)-3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:1990238", "l": "double-stranded DNA endonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16721", "l": "5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.5.98.1", "l": "\"methylenetetrahydromethanopterin dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28807", "l": "glutathione + H2O = L-cysteinylglycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54018", "l": "(8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40460", "l": "(2S)-pristanoyl-CoA + O2 => (2E)-pristenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10656", "l": "guanidinoacetate + S-adenosyl-L-methionine = creatine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.2", "l": "\"guanidinoacetate N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031769", "l": "glucagon receptor binding", "d": ["Binding to a glucagon receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59253", "l": "(E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate => (E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20791", "l": "NAD(+) + phosphate <=> ADP-alpha-D-ribose 1''-phosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50721", "l": "FMNH2 + methanesulfinate + O2 => FMN + H(+) + H2O + methanesulfonate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033913", "l": "glucan endo-1,2-beta-glucosidase activity", "d": ["Catalysis of the random hydrolysis of (1->2)-glucosidic linkages in (1->2)-beta-D-glucans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983259", "l": "Kinesins move along microtubules consuming ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662620", "l": "MT3 binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008832", "l": "RUNX2 binds BAX gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5631941", "l": "SESN1,2,3 bind AMPK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69116", "l": "Formation of Okazaki fragments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55904", "l": "7-chloro-L-tryptophan + chloride + FADH2 + O2 = 6,7-dichloro-L-tryptophan + FAD + 2 H2O", "d": []}, {"i": "EC:1.14.19.60", "l": "\"7-chloro-L-tryptophan 6-halogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13837", "l": "cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) = 4,5-dihydroxyphthalate + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.64", "l": "\"phthalate 4,5-cis-dihydrodiol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68833", "l": "(2Z,6Z)-farnesyl diphosphate + H2O => (6Z)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69170", "l": "2 H(+) + N-(2-carboxyethyl)spermidine + NADH => H2O + NAD(+) + spermine monoaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22989", "l": "3-oxopropanoate + CoA + NADP(+) => acetyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51370", "l": "CoA + H(+) + N-octadecanoylglycine => glycine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22914", "l": "3-methyl-2-oxobutanoate + L-alanine => L-valine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.40", "l": "\"(R)-2-hydroxyglutarate--pyruvate transhydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45010", "l": "octadecanoate + sphinganine => H2O + N-(octadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45625", "l": "ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine => AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65627", "l": "hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine <=> CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952996", "l": "E2F7 forms homodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50827", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 <=> 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592362", "l": "Activation of proMMP7 by MMP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40454", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75366", "l": "thymidine(in) <=> thymidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050530", "l": "glucosylglycerol 3-phosphatase activity", "d": ["Catalysis of the reaction: 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + H2O = 2-O-(beta-D-glucosyl)-sn-glycerol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70449", "l": "a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44779", "l": "2-demethylmenaquinol-6 + S-adenosyl-L-methionine <=> H(+) + menaquinol-6 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49069", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295632", "l": "PPA2A dephosphorylates SPRY2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51880", "l": "3,4,6-trichlorocatechol + O2 = (2Z,4E)-2,3,5-trichloromuconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75016", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hexadecanoyloxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44697", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O => a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14351", "l": "an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30335", "l": "CTP + H(+) + H2O = NH4(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73797", "l": "FAICAR => IMP + H2O (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64112", "l": "an N-acyl-L-phenylalanine + H2O = a fatty acid + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392513", "l": "Rap1 signal termination by Rap1GAPs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990725", "l": "cord factor receptor activity", "d": ["Combining with a cord factor, an M. tuberculosis cell wall glycolipid, and transmitting a signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77094", "l": "Formation of cap binding complex (CBC) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211959", "l": "CYP3A43 6b-hydroxylates TEST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692941", "l": "BACE1:GGA1,2,3 translocates from plasma membrane to endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44925", "l": "2-oxoadipate + acetyl-CoA + H2O => (R)-dihomocitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71090", "l": "17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) <=> 17beta-estradiol 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.23", "l": "\"ribotoxin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382057", "l": "Release of novel PDGFs as latent factors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47059", "l": "4alpha-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103056", "l": "gibberellin A53, 2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A53 + O2 + 2-oxoglutarate <=> gibberellin A44 diacid + carbon dioxide + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32723", "l": "L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762246", "l": "ANGPTL4 binds CDH11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53743", "l": "[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O <=> [Rab1 protein]-L-tyrosine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176445", "l": "SMURF2 binds SMAD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000016", "l": "lactase activity", "d": ["Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.938386572175233", "identifiers": [{"i": "GO:0016783", "l": "sulfurtransferase activity", "d": ["Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52188", "l": "1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione = (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32764", "l": "(3R)-3-methyl-D-ornithine + ATP + L-lysine => (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758501", "l": "Expression of MIXL1 in the primitive streak (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21897", "l": "(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP => adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23112", "l": "6-methylsalicylate + H(+) = 3-methylphenol + CO2", "d": []}, {"i": "EC:4.1.1.52", "l": "\"6-methylsalicylate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41208", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57449", "l": "ATP + D-tyrosine + tRNA(Tyr) => AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0070025", "l": "carbon monoxide binding", "d": ["Binding to carbon monoxide (CO)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750660", "l": "Glycine conjugates translocates from mitochondrial matrix to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168641", "l": "TAK1 associated with the CBM complex phosphorylates IKKbeta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047592", "l": "5-pyridoxate dioxygenase activity", "d": ["Catalysis of the reaction: 5-pyridoxate + NADPH + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate) + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68158", "l": "diphosphate + N-geranyl-L-glutamate => (2E)-geranyl diphosphate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53549", "l": "prostaglandin J2 => Delta(12)-prostaglandin J2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687107", "l": "MAPK4,6 translocate to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938217", "l": "RUNX1 binds the SWI/SNF complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21208", "l": "H2O + O-phospho-L-serine = L-serine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399711", "l": "Activation of Ca impermeable AMPA receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39517", "l": "(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+) => (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25968", "l": "(S)-benzoin + NADP(+) = benzil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985460", "l": "RUNX2 binds RB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.35", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41402", "l": "1-hexanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-hexanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39601", "l": "(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+) => 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981926", "l": "RAC1 and CDC42 activate PAK3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170120", "l": "Translocation of Cdc25B to the cytoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381091", "l": "IRE1 dimer autophosphorylates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214956", "l": "Full-length EA is cleaved by SNK serine protease (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418456", "l": "cGMP is degraded by PDEs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24374", "l": "H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine => H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76426", "l": "N-atom dealkylation of caffeine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41180", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23008", "l": "alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate", "d": []}, {"i": "EC:3.2.1.93", "l": "\"alpha,alpha-phosphotrehalase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33134", "l": "L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate <=> 3-phenylpyruvate + tetrahydrotyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654623", "l": "Activated FGFR3 binds FRS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193981", "l": "CYP21A2 oxidises 17HPROG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9725855", "l": "NR3C2 binds NR3C2 antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50735", "l": "4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983147", "l": "Release of E3 from polyubiquitinated substrate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48652", "l": "lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9793472", "l": "RIPK3 binds p-S9-PRKN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61022", "l": "5'-deoxyadenosine + 5-(carboxymethyl)uridine(34) in tRNA + CoA + 2 H(+) + L-methionine => acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70020", "l": "O2 + reduced [NADPH--hemoprotein reductase] + typhasterol => 7-oxatyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9681375", "l": "KIT binds ripretinib (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.21", "l": "\"coagulation factor VIIa\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46681", "l": "2 Fe(III)-[cytochrome b5] + NADH => 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.121", "l": "\"aldose 1-dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654571", "l": "Activated FGFR1 binds FRS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25867", "l": "H2O + N(1)-acetylspermidine + O2 <=> 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163320", "l": "Association of mTERF with the termination sequence (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047738", "l": "cellobiose phosphorylase activity", "d": ["Catalysis of the reaction: cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390930", "l": "5-HT2 receptor can bind serotonin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44296", "l": "2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA = 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50642", "l": "3-(2-methylsulfanyl)ethylmalate => 2-(2-methylsulfanyl)ethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14751", "l": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+) => 1-hydroxy-2-naphthoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64486", "l": "3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA => acetyl-CoA + 6 H(+) + holo-[ACP] + 6 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73923", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + S-adenosyl-L-methionine = griseophenone D + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47645", "l": "adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42401", "l": "lactose(out) + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + lactose 6-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462003", "l": "HNP1-4 are stored in primary neutrophil granules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61142", "l": "CO2 + H(+) + H2O + myricetin + succinate => (2R,3R)-dihydromyricetin + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61766", "l": "H(+) + rebaudioside E + UDP => stevioside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73888", "l": "chloride(out) + Na(+)(out) => chloride(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635102", "l": "GPR161 is internalized (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629679", "l": "PDE3A inhibitors bind PDE3A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749609", "l": "BCHE hydrolyzes ASA- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75481", "l": "S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out) => S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65361", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O => a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168880", "l": "vRNP Export through the nuclear pore (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73465", "l": "beta-alanine + histamine => carcinine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428273", "l": "SPHK1 phosphorylates SPG to S1P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71047", "l": "glycine(in) + L-phenylalanine(out) = glycine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53537", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50345", "l": "3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH => 3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20638", "l": "D-fructose + D-glucose => D-glucono-1,5-lactone + D-sorbitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977301", "l": "Histidine is decarboxylated to histamine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30753", "l": "AMP + diphosphate + hexadecanoyl-CoA => ATP + CoA + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956568", "l": "RUNX1 binds the core TAL1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018547", "l": "nitroglycerin reductase activity", "d": ["Catalysis of the removal of one or more nitrite (NO2-) groups from nitroglycerin or a derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.71", "l": "\"arylamine glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019160", "l": "NMN nucleosidase activity", "d": ["Catalysis of the reaction: H2O + nicotinamide mononucleotide = D-ribose 5-phosphate + H+ + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58522", "l": "akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205238", "l": "SHP2 interacts with p-KIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42237", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103103", "l": "UDP-glucose: 9-methylthiononylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 9-methylthiononylhydroximate <=> 8-methylthiooctyldesulfoglucosinolate + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25243", "l": "(S)-ureidoglycolate + NH4(+) => (S)-2-ureidoglycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690023", "l": "NUBPL binds 4Fe-4S (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9028730", "l": "Activated NTRK2 binds FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37322", "l": "ATP + glycyl-L-methionine(out) + H2O <=> ADP + glycyl-L-methionine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168638", "l": "Activated IKK phosphorylates I-kappaB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75821", "l": "(5S)-hydroperoxy-(6E,8Z)-octadecadienoate => (5Z,8Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0097157", "l": "pre-mRNA intronic binding", "d": ["Binding to an intronic sequence of a pre-messenger RNA (pre-mRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3781941", "l": "WNTs are secreted in exosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2127285", "l": "NOTCH2 stimulates transcription of FCER2 (CD23A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50171", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912369", "l": "NOTCH precursor cleaved to form mature NOTCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75664", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate => 10,11-epoxy-12-hydroxy-(14Z)-eicosenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74026", "l": "L-alanine(in) + L-serine(out) <=> L-alanine(out) + L-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005300", "l": "high-affinity tryptophan transmembrane transporter activity", "d": ["Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029680", "l": "Caspase-7 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24277", "l": "acetate + diphosphate => acetyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823958", "l": "EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982017", "l": "Active G alpha (q) binds RGS proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74290", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA <=> an acyl-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.9.-", "l": "\"With a copper protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41289", "l": "sphing-4-enine + tetradecanoate => H2O + N-tetradecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32562", "l": "(2E)-geranyl diphosphate <=> diphosphate + gamma-terpinene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40210", "l": "(2E)-tetradecenedioyl-CoA + H2O <=> (3S)-hydroxytetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088309", "l": "FOXM1 binds CCNB2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62289", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate => (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218806", "l": "FYN autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72454", "l": "a dicarboxylate(in) + dehydroepiandrosterone 3-sulfate(out) <=> a dicarboxylate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656070", "l": "FGFBPs bind FGFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-606287", "l": "RSF complex binds the centromere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0015186", "l": "L-glutamine transmembrane transporter activity", "d": ["Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50784", "l": "dodecanal + NADP(+) = (2E)-dodecenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66493", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24322", "l": "an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53219", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17383", "l": "(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871373", "l": "BMX phosphorylates RUFY1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17799", "l": "[(1->4)-beta-D-glucosyl](n+1) + GDP + H(+) => [(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70924", "l": "(R)-noradrenaline(out) + chloride(out) + Na(+)(out) => (R)-noradrenaline(in) + chloride(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648880", "l": "Ferriheme dissociates from p-T-EIF2AK1:2xferriheme dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-606349", "l": "Mis18 complex binds the centromere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52453", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate => 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102626", "l": "parthenolide synthase activity", "d": ["Catalysis of the reaction: costunolide + NADPH + O2 + H+ <=> parthenolide + NADP(3-) + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56823", "l": "AH2 + cyclooctat-9-en-7-ol + O2 <=> A + cyclooctat-9-ene-5,7-diol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.17", "l": "\"lysozyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018816", "l": "2-hydroxyisobutyrate dehydratase activity", "d": ["Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3065958", "l": "An unknown protease degrades ACACA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62306", "l": "(+)-premalbrancheamide => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26081", "l": "(2E,6E)-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate", "d": []}, {"i": "EC:4.2.3.40", "l": "\"(Z)-gamma-bisabolene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9032798", "l": "DOCK3 activates RAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432946", "l": "PARVB/Affixin interacts with alpha PIX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947499", "l": "Exchange of oxygen with sulfur in MoCo (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34888", "l": "selenate(in) => selenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30250", "l": "2 H2O + 4 hnu + 2 plastoquinone-9 <=> O2 + 2 plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32451", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate = all-trans-phytoene + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34867", "l": "ATP + CoA + thiophene-2-carboxylate = AMP + diphosphate + thiophene-2-carbonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018775", "l": "2-hydroxymuconate-semialdehyde hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxymuconate semialdehyde + H2O = formate + 2-oxopent-4-enoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14226", "l": "6-hydroxyhexanoate + NAD(+) => 6-oxohexanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17758", "l": "H(+) + L-methionine => 3-(methylsulfanyl)propanamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33385", "l": "(S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP => (S)-malate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24840", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine", "d": []}, {"i": "EC:4.1.99.17", "l": "\"phosphomethylpyrimidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57698", "l": "adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate => ATP + cob(I)inamide-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806974", "l": "MET dimers autophosphorylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847534", "l": "RAB43 hydrolyses GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27507", "l": "cocaine + H2O => benzoate + ecgonine methyl ester + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166792", "l": "Conversion of C2 into C2a and C2b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35096", "l": "choline => acetaldehyde + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034722", "l": "gamma-glutamyl-peptidase activity", "d": ["Catalysis of the cleavage of a gamma-linked glutamate bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43792", "l": "adenosine(645) in 25S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.287", "l": "\"25S rRNA (adenine(645)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58344", "l": "beta-D-glucosyl-(1->3)-O-lithocholate + H2O = D-glucose + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61075", "l": "(-)-(R)-19-hydroxytabersonine + acetyl-CoA <=> (-)-(R)-19-O-acetyltabersonine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0043495", "l": "protein-membrane adaptor activity", "d": ["The binding activity of a molecule that brings together a protein or a protein complex with a membrane, or bringing together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31570", "l": "bisphenol A + H(+) + NADH + O2 <=> 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392513", "l": "Rap1 signal termination by Rap1GAPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58520", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63009", "l": "(6Z)-octadecenamide + H2O => (6Z)-octadecenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23161", "l": "L-rhamnopyranose => L-rhamnulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46422", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68326", "l": "1D-myo-inositol 2-phosphate + phosphate => 1D-myo-inositol 2,5-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16041", "l": "[(1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58784", "l": "2-oxoglutarate + a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 = a 5'-end triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16610", "l": "AMP + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32033", "l": "diphosphate + gamma-curcumene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042880", "l": "D-glucuronate transmembrane transporter activity", "d": ["Enables the transfer of D-glucuronate, the D-enantiomer of glucuronate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71959", "l": "3 Na(+)(out) + oxaloacetate(out) = 3 Na(+)(in) + oxaloacetate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656459", "l": "Defective KHK does not phosphorylate beta-D-fructose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37871", "l": "2-heptyl-4(1H)-quinolone + H(+) + NADH + O2 = 2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.182", "l": "\"2-heptyl-3-hydroxy-4(1H)-quinolone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43965", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA => 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50716", "l": "dimethyl sulfone + FMNH2 + O2 = FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61573", "l": "(11Z,14Z)-eicosadienoate + O2 => (15S)-hydroperoxy-(11Z,13E)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008679", "l": "2-hydroxy-3-oxopropionate reductase activity", "d": ["Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47662", "l": "CoA + H(+) + N-acetyl-L-methionine sulfoximine => acetyl-CoA + L-methionine sulfoximine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-481010", "l": "Surface deployment of platelet dense granule membrane components (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44867", "l": "a triacyl-sn-glycerol + H2O <=> a 1,2-diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52014", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004154", "l": "dihydropterin oxidase activity", "d": ["Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944454", "l": "mTORC1 phosphorylates MAF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848726", "l": "PTK6 phosphorylates BCAR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51115", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869543", "l": "TFPA2A homodimer and NPM1 bind the NOP2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106417", "l": "dopaminechrome tautomerase activity", "d": ["Catalysis of the reaction: dopaminechrome = 5,6-dihydroxyindole."]}, {"i": "RHEA:70199", "l": "dopaminechrome = 5,6-dihydroxyindole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952996", "l": "E2F7 forms homodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53289", "l": "3-dehydro-scyllo-inosose + H2O => 5-dehydro-L-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015625", "l": "ABC-type ferric hydroxamate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-hydroxamate(out) = ADP + phosphate + ferric-hydroxamate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75499", "l": "cholate(out) + n H(+)(out) = cholate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9604328", "l": "AKT1 phosphorylates NOTCH4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49916", "l": "(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.-.-", "l": "\"Acting on the CH-OH group of donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734475", "l": "PPARA binds fibrates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38866", "l": "phosphate + sucrose 6(F)-phosphate <=> alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67017", "l": "a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373732", "l": "Nephrin trans-homophilic interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11152", "l": "5-pyridoxate + NADPH + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)", "d": []}, {"i": "EC:1.14.13.241", "l": "\"5-pyridoxate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38109", "l": "L-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-L-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9713785", "l": "Anti-cancer drugs generate DNA interstrand crosslinks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209141", "l": "ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34068", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate => diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5213462", "l": "RIPK3 binds RIPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35760", "l": "8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941312", "l": "TUT4,TUT7 oligouridylate mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20749", "l": "2-oxoglutarate + O2 + penicillin N => CO2 + deacetoxycephalosporin C + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47033", "l": "AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA => 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203977", "l": "SAR1 Activation And Membrane Binding (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47030", "l": "[DsrC protein]-disulfide + H(+) + sulfite => [DsrC protein]-S-sulfo-L-cysteine/L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27963", "l": "myo-inositol + pyrroloquinoline quinone => H(+) + pyrroloquinoline quinol + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33038", "l": "2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64519", "l": "2-hydroxyethane-1-sulfonate + NAD(+) <=> H(+) + NADH + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762333", "l": "ANGPTL4 binds to CDH11v (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21527", "l": "3-methyl-2-oxobutanoate + acetyl-CoA + H2O <=> (2S)-2-isopropylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23019", "l": "(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) <=> (2R,3R)-dihydrokaempferol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50529", "l": "acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66084", "l": "L-kynurenine + oxaloacetate = H2O + kynurenate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52568", "l": "epitestosterone + UDP-alpha-D-glucuronate = epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390846", "l": "D2D3,4 bind to DA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419841", "l": "Light stimulates opsin receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167419", "l": "The receptor:G-protein complex releases GDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050089", "l": "mannose isomerase activity", "d": ["Catalysis of the reaction: D-mannose = D-fructose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33314", "l": "2 A + hydroxylamine + NH4(+) <=> 2 AH2 + H(+) + H2O + N2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56033", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67113", "l": "L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10869", "l": "a 1,2-diacyl-sn-glycerol + an acyl-CoA => a triacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16739", "l": "(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) => H(+) + NADH + O2 + toluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72908", "l": "D-mannose(out) + Na(+)(out) => D-mannose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008054", "l": "IL1F10 binds IL1RAPL1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010435", "l": "3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity", "d": ["Catalysis of the reaction: ATP + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid + coenzyme A = AMP + diphosphate + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoyl-CoA + H+. 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid is also known as OPC-8:0."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1629787", "l": "Synthesis of Cx26 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13161", "l": "L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.103", "l": "\"L-threonine 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40439", "l": "6-sulfo-beta-D-quinovose = 6-deoxy-6-sulfo-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692738", "l": "HRH2 binds HRH2 antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60978", "l": "(E)-4-hydroxynon-2-enal + H(+) + NADH => (E)-4-hydroxynon-2-en-1-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72601", "l": "N-acetyl-L-aspartyl-L-glutamate(in) => N-acetyl-L-aspartyl-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783880", "l": "PIPOX oxidises PPCA to P6C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008696", "l": "4-amino-4-deoxychorismate lyase activity", "d": ["Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H+ + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199298", "l": "AKT phosphorylates CREB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66464", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O = scalarane-17alpha-19-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59853", "l": "(2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH => (R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46282", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22733", "l": "4-hydroxyphenylacetate + H(+) => 4-methylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507873", "l": "Aquaporins passively transport urea out of cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65674", "l": "a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707586", "l": "FeHM oxidises LDL,HDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38759", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030058", "l": "amine dehydrogenase activity", "d": ["Catalysis of the reaction: an aliphatic amine + an acceptor (A) + H2O = an aldehyde + a reduced acceptor (AH2) + NH4+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72735", "l": "UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) = UDP-N-acetyl-alpha-D-galactosamine(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57111", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17673", "l": "quercetin + S-adenosyl-L-methionine = 3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.76", "l": "\"quercetin 3-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38046", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851988", "l": "BTN2A2 binds T cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63370", "l": "ADP + H(+) + phosphate + spermine(in) => ATP + H2O + spermine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31958", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683925", "l": "ULK1 is dephosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35970", "l": "fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14576", "l": "D-glucarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875568", "l": "RAPGEF1 activates RAP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58906", "l": "C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+) => 8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58312", "l": "25-substituted-cholesteryl beta-D-glucoside + H2O = 25-substituted-cholesterol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37055", "l": "3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate = 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate", "d": []}, {"i": "EC:2.5.1.111", "l": "\"4-hydroxyphenylpyruvate 3-dimethylallyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63080", "l": "AH2 + ATP + ilicicolinate B = A + AMP + diphosphate + ilicicolin B", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.706056554619465", "identifiers": [{"i": "GO:0140303", "l": "intramembrane lipid transporter activity", "d": ["Enables the transport of a lipid from a region of a membrane to a different region on the same membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49957", "l": "5,10-dihydrophenazine 1-carboxylate + O2 => H2O2 + phenazine-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76106", "l": "(11R)-carlactonoate + S-adenosyl-L-methionine <=> (11R)-methyl carlactonoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71946", "l": "(S)-malate(out) + 3 Na(+)(out) <=> (S)-malate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009309", "l": "RUNX2 binds STUB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70023", "l": "4-hydroxy-L-proline(in) + Na(+)(in) = 4-hydroxy-L-proline(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54604", "l": "2-oxoglutarate + decanoyl-CoA + O2 = 2-hydroxydecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211948", "l": "CYP3A4 can N-demethylate loperamide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211206", "l": "Translocation of DFF to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23834", "l": "ADP + an N-acyl-D-mannosamine 6-phosphate + H(+) => an N-acyl-D-mannosamine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18265", "l": "6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) = 6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.368", "l": "\"6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16454", "l": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O => 2-formylbenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870466", "l": "RGGT:CHM binds RABs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49818", "l": "3 Fe(II)-[cytochrome c] + 2 H(+) + NH4(+) + nitric oxide => 3 Fe(III)-[cytochrome c] + H2O + hydrazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805109", "l": "CDK2 phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847537", "l": "RAB43:GTP binds USP8NL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917700", "l": "MVB Vesicle Formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30593", "l": "(4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+) => H2O + O2 + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1006169", "l": "Factor H binds host cell surface markers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36715", "l": "sphinganine + tetracosenoyl-CoA = an N-tetracosenoylsphinganine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22995", "l": "3-oxopropanoate + CoA + NAD(+) <=> acetyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603275", "l": "Defective TBXAS1 does not isomerise PGH2 to TXA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72927", "l": "O2 + proatranorin I + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin IV", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25759", "l": "ent-copalyl diphosphate = diphosphate + ent-isokaurene", "d": []}, {"i": "EC:4.2.3.103", "l": "\"ent-isokaurene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75261", "l": "3'-dehydroisoorientin + H2O2 => isoorientin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34092", "l": "(5R)-5-phosphooxy-L-lysine + H2O => (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9005980", "l": "IL21 binds IL21R:JAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416690", "l": "SEMA4A binds to PLXND1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41582", "l": "5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate => 5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72169", "l": "2 Na(+)(in) + taurohyodeoxycholate(in) => 2 Na(+)(out) + taurohyodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39101", "l": "acetyl-CoA + octanedioyl-CoA => 3-oxodecanedioyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22849", "l": "(3S)-hydroxyoctanedioyl-CoA + NAD(+) => 3-oxooctanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44956", "l": "(2E)-hexenoyl-CoA + H(+) + NADPH = hexanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36773", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33802", "l": "L-histidinol + NAD(+) <=> H(+) + L-histidinal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13963", "l": "ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate => ATP + H2O + Mg(2+) + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37128", "l": "2-oxoglutarate + dioxidophosphate + H2O2 => CO2 + H(+) + phosphonate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50180", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74031", "l": "L-alanine(in) + L-cysteine(out) = L-alanine(out) + L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730899", "l": "Oligomerization of BCL10 and MALT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46820", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37790", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704330", "l": "Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043898", "l": "2,3-dihydroxybiphenyl 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxybiphenyl + O2 = 2-hydroxy-6-phenylhexa-2,4-dienoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61891", "l": "diosgenin + UDP-alpha-D-glucose <=> diosgenin 3-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392513", "l": "Rap1 signal termination by Rap1GAPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41914", "l": "hexadecanoyl-[ACP] + NADP(+) => (2E)-hexadecenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.79713023523334", "identifiers": [{"i": "GO:0005198", "l": "structural molecule activity", "d": ["The action of a molecule that contributes to the structural integrity of a complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38578", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73088", "l": "AMP(out) + FAD(in) => AMP(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-984606", "l": "Kinesin-5 is a homotetramer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008687", "l": "3,4-dihydroxyphenylacetate 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O2 = 5-formyl-2-hydroxyhepta-2,4-dienedioate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69948", "l": "3-dehydro-6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydro-6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58413", "l": "3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin] => H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352268", "l": "Cleavage of Satb1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21410", "l": "3-phenylpyruvate + H(+) + NADH + NH4(+) => H2O + L-phenylalanine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704692", "l": "SARS-CoV-1 7a binds BCL2L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878654", "l": "ACP6 hydrolyses MYS-LPA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20135", "l": "H(+) + indole-3-pyruvate + NADH => 3-(indol-3-yl)lactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8963915", "l": "1,25(OH)2D binds VDR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70510", "l": "LDH tetramer oxidises LACT to PYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69612", "l": "H2O + kojibiose => beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120019", "l": "phosphatidylcholine transfer activity", "d": ["Removes phosphatidylcholine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73505", "l": "3',4,7-trihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54090", "l": "2,4,5-trihydroxyphenylacetate + H2O + NAD(+) => 3,4-dihydroxyphenylacetate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39060", "l": "26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863973", "l": "Fusion of ERC and phagosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210439", "l": "glutamate uptake by astrocytes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34681", "l": "adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate => ATP + methylphosphonate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990585", "l": "hydroxyproline O-arabinosyltransferase activity", "d": ["Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline <=> a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41911", "l": "(3R)-hydroxyhexadecanoyl-[ACP] <=> (2E)-hexadecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28784", "l": "H2O + L-cysteinylglycine => glycine + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64767", "l": "S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine <=> 2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11804", "l": "an aromatic aldehyde + H2O + NAD(+) = an aromatic carboxylate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.29", "l": "\"aryl-aldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18248", "l": "3'-dephospho-CoA + ATP <=> ADP + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40020", "l": "ent-copalyl diphosphate + H2O => (-)-ent-copalol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082356", "l": "HSF1-mediated gene expression (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27580", "l": "(R)-piperazine-2-carboxylate + tert-butylamine => (R)-N-tert-butylpiperazine-2-carboxamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166753", "l": "Conversion of C4 into C4a and C4b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11838", "l": "CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine => CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034580", "l": "4-methyloctanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 4-methyloctanoyl-CoA = 4-methyloct-2-enoyl-CoA + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66649", "l": "(2E,6E)-farnesyl diphosphate => african-3-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14532", "l": "ADP + D-ribose 5-phosphate + H(+) <=> ADP-D-ribose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45837", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203613", "l": "depalmitoylation of eNOS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694442", "l": "CNIH2,3 bind GRIA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27981", "l": "GDP-alpha-D-mannose + H2O <=> alpha-D-mannose 1-phosphate + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72866", "l": "3',3',3'-cAAG + H2O <=> G[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69378", "l": "2-oxododecanoate + H2O2 => 2-hydroxydodecanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8856157", "l": "LAG3 (CD233) binds MHC II (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23700", "l": "5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)", "d": []}, {"i": "EC:3.5.4.9", "l": "\"methenyltetrahydrofolate cyclohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63303", "l": "N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174058", "l": "Degradation of multiubiquitinated Cdh1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451895", "l": "IL2RG binds JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31429", "l": "(1S,5S,6R)-alpha-bergamotene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917693", "l": "ESCRT Disassembly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46953", "l": "2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41064", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45950", "l": "CoA + H(+) + N(6)-acetyl-L-lysyl-[protein] => acetyl-CoA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-349404", "l": "CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69392", "l": "an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20796", "l": "aldehydo-D-ribose = D-ribulose", "d": []}, {"i": "EC:5.3.1.20", "l": "\"ribose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295622", "l": "SPRY2 binds CBL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913371", "l": "GM-CSF receptor alpha:GM-CSF binds Bc (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15188", "l": "L-arginine + succinyl-CoA <=> CoA + H(+) + N(2)-succinyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28832", "l": "D-gluconate(in) + H(+)(in) => D-gluconate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249378", "l": "STING recruits TBK1 and STAT6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41190", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20355", "l": "AH2 + tetrachloroethene => A + chloride + H(+) + trichloroethene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73560", "l": "dGTP(out) + UTP(in) => dGTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71847", "l": "glycoursodeoxycholate(out) = glycoursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0015666", "l": "restriction endodeoxyribonuclease activity", "d": ["Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10777", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) => 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40326", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50631", "l": "a 2-(omega-methylsulfanyl)alkylmalate <=> a 3-(omega-methylsulfanyl)alkylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10946", "l": "phosphate + pseudouridine => H2O + psi-UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696960", "l": "USP49 deubiquitinates H2B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64532", "l": "an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74986", "l": "Elongation of pre-rRNA transcript (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030751", "l": "licodione 2'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + licodione = 2'-O-methyllicodione + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685319", "l": "CX3 complex formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24970", "l": "H2O + 2 oxidized [adrenodoxin] + secalciferol => calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55455", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10272", "l": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.107", "l": "\"diacylglycerol kinase (ATP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0140489", "l": "molecular template activity", "d": ["The action of a molecule that provides a shape or a sequence mimicking or complementary to the final product, providing template for copying the original molecule's shape or sequence."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9736953", "l": "FURIN translocates to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674531", "l": "AAMP binds EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59027", "l": "H2O + trihexadecanoylglycerol <=> dihexadecanoylglycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045484", "l": "L-lysine 6-transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-lysine = L-glutamate + allysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37997", "l": "2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate => all-trans-nonaprenyl diphosphate + H(+) + homogentisate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26224", "l": "abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201639", "l": "Caspase-mediated cleavage of GAS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27780", "l": "2-all-trans-octaprenylphenol + CO2 => 4-hydroxy-3-all-trans-octaprenylbenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16527", "l": "2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+) => 2-dehydro-3-deoxy-D-galactonate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32518", "l": "(4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O <=> (3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43219", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine <=> (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33067", "l": "(4R)-hydroxysphinganine 1-phosphate + H2O = (4R)-hydroxysphinganine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784861", "l": "HSPG binds LPL dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114553", "l": "Activation of conventional Protein Kinase C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11055", "l": "4-aminobenzoate + 2 H(+) + NADH + O2 <=> 4-aminophenol + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10142", "l": "H(+) + NADPH + prostaglandin D2 => NADP(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32277", "l": "3-amino-2-oxopropyl phosphate + CO2 + NADH => 4-(phosphooxy)-L-threonine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015309", "l": "cycloheximide:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850777", "l": "SPINK6 binds KLK14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033998", "l": "inulin fructotransferase (DFA-III-forming) activity", "d": ["Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride (DFA III) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27752", "l": "2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine => 2'-deoxyinosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13488", "l": "2-oxoglutarate + S-(4-bromophenyl)-L-cysteine <=> 3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33410", "l": "ATP + glycine + H(+) <=> diphosphate + glycyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070080", "l": "titin Z domain binding", "d": ["Binding to a titin Z protein domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25741", "l": "H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43551", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46100", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = cortisol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49799", "l": "an N-(fatty acyl)-glycine + H2O <=> a fatty acid + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114671", "l": "vWF binds to collagen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662595", "l": "MT1E binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44356", "l": "nogalaviketone = methyl nogalonate", "d": []}, {"i": "EC:5.5.1.26", "l": "\"nogalonic acid methyl ester cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48497", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose => 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018560", "l": "protocatechuate 3,4-dioxygenase type II activity", "d": ["Catalysis of the reaction: 4-sulfocatechol + O2 = 3-sulfomuconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62335", "l": "ADP + ATP <=> adenosine 3'-diphosphate,5'-diphosphate + AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592316", "l": "Initial activation of proMMP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.254", "l": "\"erythromycin 3''-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70482", "l": "H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374896", "l": "Uptake of Noradrenaline (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856808", "l": "Recruitment of AP-2 complex and clathrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483219", "l": "PC is exchanged with PI by PITPNB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004062", "l": "aryl sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41148", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41711", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63684", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP = (4R,5S)-dethiobiotin + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75718", "l": "CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + pantetheine 4'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10357", "l": "3alpha-hydroxy-5beta-androstan-17-one + NAD(+) => 5beta-androstane-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012074", "l": "FGFR3c P250R mutant binds to ligand with enhanced affinity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12700", "l": "ATP + dGMP <=> ADP + dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.154", "l": "\"ureidoglycolate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858428", "l": "FCAMR binds IgA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217017", "l": "Deubiquitination of FancD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31705", "l": "H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol => 2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707505", "l": "Hemes bind to CLEC1B dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080066", "l": "3-methylthiopropyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 3-methylthiopropyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 3-methylthiopropyl-glucosinolate + adenosine 3',5'-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40745", "l": "(20S)-ginsenoside C-K + 2 D-glucose => (20S)-ginsenoside Rd + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71846", "l": "tauroursodeoxycholate(out) <=> tauroursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676595", "l": "TRAFs bind RANK:RANKL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0034069", "l": "aminoglycoside N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + N-acetylaminoglycoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58883", "l": "4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66133", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45712", "l": "3-dehydrocarnityl-CoA + CoA = acetyl-CoA + N,N,N-trimethylglycyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36502", "l": "2-dehydro-3-deoxy-L-rhamnonate + NAD(+) <=> 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25377", "l": "a 2-methyl-branched fatty aldehyde + formyl-CoA => a 2-hydroxy-3-methyl fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "47.189146448501944", "identifiers": [{"i": "GO:0022839", "l": "monoatomic ion gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9658813", "l": "OGG1 S326C is oxidized (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31822", "l": "(2E,6E)-farnesyl diphosphate <=> 5-epi-alpha-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71334", "l": "chloride(out) + L-phenylalanine(out) + 2 Na(+)(out) <=> chloride(in) + L-phenylalanine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15326", "l": "an acyl-CoA + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75519", "l": "FMNH2 + N-acetyl-S-benzyl-L-cysteine + O2 = (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602458", "l": "Activation of proMMP10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170986", "l": "Ral-GDS binds to Ras-GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49153", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine => dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852324", "l": "GTSE1 binds PLK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30796", "l": "2-oxoadipate + CoA + NAD(+) => CO2 + glutaryl-CoA + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53403", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38279", "l": "(3R)-citramalate + succinyl-CoA = (3R)-citramalyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30874", "l": "2-deoxy-D-ribose + ATP <=> 2-deoxy-D-ribose 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59587", "l": "ATP + beta-alanine + L-lysine <=> ADP + beta-alanyl-L-lysine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450551", "l": "AUF1 binds translation and heat shock proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607733", "l": "BCL10 binds CARD9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714481", "l": "RAC2 binds effectors at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939204", "l": "ESTG binds ESR1:chaperone complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67432", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65324", "l": "acetyl-CoA + chrodrimanin A = chrodrimanin B + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32247", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) = (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36243", "l": "(E)-anol + acetate + NADP(+) = (E)-coumaryl acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46877", "l": "[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate => [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51871", "l": "dimethylallyl diphosphate + umbelliferone <=> demethylsuberosin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888589", "l": "Release of GABA at the synapse (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798624", "l": "ZNF420 binds TP53AIP1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14018", "l": "ATP + beta-nicotinamide D-riboside => ADP + beta-nicotinamide D-ribonucleotide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63940", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2 = 2 Fe(III)-[cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654573", "l": "Activated FGFR1 binds SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018594", "l": "MECP2 binds LBR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28274", "l": "(S)-S-adenosyl-L-methionine = (R)-S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.77", "l": "\"alkyl sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65933", "l": "3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine => 3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052768", "l": "mannosyl-oligosaccharide 1,3-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of the alpha-(1->3) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47094", "l": "dipicolinate + H(+) + NADPH => (S)-2,3-dihydrodipicolinate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30117", "l": "decanoate + H(+) + holo-[ACP] => decanoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725206", "l": "IgE binds FCERI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047644", "l": "alizarin 2-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: alizarin + UDP-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42938", "l": "2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(32) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22748", "l": "4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56678", "l": "(E)-feruloyl-CoA + H(+) + NADPH => dihydroferuloyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606392", "l": "Lewis antigens translocate from Golgi lumen to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10113", "l": "L-homocysteine + L-serine => H2O + L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043780", "l": "cobalt-precorrin-5B C1-methyltransferase activity", "d": ["Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28145", "l": "H2O + streptothricin D <=> streptothricin D acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74234", "l": "H2O + L-threonyl-tRNA(Val) <=> L-threonine + tRNA(Val)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21280", "l": "H2O + 2 O2 + thiamine = H(+) + 2 H2O2 + thiamine acetate", "d": []}, {"i": "EC:1.1.3.23", "l": "\"thiamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10075", "l": "N,N-dimethylglycine + S-adenosyl-L-methionine <=> glycine betaine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31415", "l": "(2Z,6E)-farnesyl diphosphate = (+)-2-epi-prezizaene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689317", "l": "Formation of the pre-incision complex in GG-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21155", "l": "trans-4-hydroxy-L-proline <=> cis-4-hydroxy-D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003852", "l": "2-isopropylmalate synthase activity", "d": ["Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49232", "l": "D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannose 6-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.191", "l": "\"protein-N(pi)-phosphohistidine--D-mannose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34695", "l": "(2E,6E)-farnesyl diphosphate = Delta(6)-protoilludene + diphosphate", "d": []}, {"i": "EC:4.2.3.135", "l": "\"Delta(6)-protoilludene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71147", "l": "3-hydroxyhispidin + O2 = 4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60829", "l": "a 5'-end triphospho-adenosine in mRNA + H2O => a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27556", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate => all-trans-hexaprenyl diphosphate + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008412", "l": "CDK4 phosphorylates RUNX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21844", "l": "L-glutamine + phenylacetyl-CoA = CoA + H(+) + N(2)-phenylacetyl-L-glutamine", "d": []}, {"i": "EC:2.3.1.14", "l": "\"glutamine N-phenylacetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191402", "l": "Reduction of presqualene diphosphate to form squalene (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59406", "l": "D-homoserine => L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.16", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097429", "l": "amino acid ligation activity by nonribosomal peptide synthase", "d": ["Catalysis of the ligation of an amino acid to another amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate, carried out by a nonribosomal peptide synthase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709360", "l": "H2O2 reduces MetHb (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109860", "l": "MAP2K1 phosphorylates MAPK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30091", "l": "a ubiquinone + D-alanine + H2O = a ubiquinol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75640", "l": "(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate => (12S,13R)-epoxy-(10R)-hydroxy-(8E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64560", "l": "butan-2-ol + NAD(+) = butan-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27620", "l": "di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate => (2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392195", "l": "Gi activation by P2Y purinoceptor 12 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45931", "l": "15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55281", "l": "13-cis-retinol + tetradecanoyl-CoA => 13-cis-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621404", "l": "CYP51A1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25163", "l": "2-oxoglutarate + L-ornithine <=> L-glutamate + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871227", "l": "RET binds GFRA4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936667", "l": "sulfate binds to SubI outside the membrane (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75913", "l": "a fatty acid + H(+) + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => H2O + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11228", "l": "(2S)-flavan-4-ol + NADP(+) = (2S)-flavanone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.234", "l": "\"flavanone 4-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156682", "l": "PLK1 phosphorylates NUDC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47284", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68960", "l": "7,8-dihydroxycoumarin + S-adenosyl-L-methionine = 7-hydroxy-8-methoxycoumarin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.422", "l": "\"pseudoephedrine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399941", "l": "AKT1 E17K mutant phosphorylates BAD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013009", "l": "RHOA binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55373", "l": "H2O + methyl (-)-jasmonate => H(+) + jasmonate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54676", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (+)-kolavenyl diphosphate", "d": []}, {"i": "EC:5.5.1.29", "l": "\"(+)-kolavenyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2321904", "l": "PTEN mRNA translation negatively regulated by microRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55845", "l": "calcidiol + UDP-alpha-D-glucuronate => calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0016649", "l": "oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound."]}, {"i": "EC:1.5.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682026", "l": "MRN bound to shortened telomeres activates ATM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35171", "l": "H(+)(out) + novobiocin(in) = H(+)(in) + novobiocin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018783", "l": "deisopropyldeethylatrazine hydrolase activity", "d": ["Catalysis of the reaction: deisopropyldeethylatrazine + H2O = 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202248", "l": "Phosphorylation of PLC-gamma1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66866", "l": "diphosphate + quiannulatene => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73448", "l": "acetyl-CoA(in) + AMP(out) => acetyl-CoA(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14690", "l": "4-chlorophenylacetate + NADH + O2 => 3,4-dihydroxyphenylacetate + chloride + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66721", "l": "ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in) => ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047707", "l": "biotin-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25528", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": []}, {"i": "EC:3.1.3.86", "l": "\"phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018799", "l": "4-hydroxybenzoate decarboxylase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + H+ = CO2 + phenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27646", "l": "inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66165", "l": "butanoyl-CoA + serotonin => CoA + H(+) + N-butanoylserotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852331", "l": "GTSE1 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31463", "l": "crocetin + UDP-alpha-D-glucose = beta-D-glucosyl crocetin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-933533", "l": "Dimerization of p-IRF7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22611", "l": "H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate <=> (2S,6S)-2,6-diaminoheptanedioate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392749", "l": "Transport of L1 into endosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24202", "l": "aniline + CO2 => 4-aminobenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16884", "l": "hydrogen cyanide + thiosulfate <=> 2 H(+) + sulfite + thiocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65439", "l": "a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.74456172809515", "identifiers": [{"i": "GO:0015175", "l": "neutral L-amino acid transmembrane transporter activity", "d": ["Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162229", "l": "The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47307", "l": "(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10488", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate", "d": []}, {"i": "EC:6.3.3.2", "l": "\"5-formyltetrahydrofolate cyclo-ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694406", "l": "nsp13 binds DDX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604606", "l": "Unknown kinase phosphorylates NICD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73571", "l": "(E,E)-piperate + ATP + CoA = (E,E)-piperoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74681", "l": "UDP-beta-L-arabinofuranose(out) + UMP(in) => UDP-beta-L-arabinofuranose(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43986", "l": "(2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+) => (2E,6E)-farnesol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29765", "l": "ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate => ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43158", "l": "H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine => guanosine(9) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26545", "l": "(R)-piperazine-2-carboxamide + H2O <=> (R)-piperazine-2-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102803", "l": "thebane O-demethylase activity", "d": ["Catalysis of the reaction: thebaine + 2-oxoglutarate + O2 <=> oripavine + formaldehyde + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28758", "l": "a ubiquinone + sn-glycerol 3-phosphate <=> a ubiquinol + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734687", "l": "ORC6 is phosphorylated on T195 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689544", "l": "UCHL5 binds INO80 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418662", "l": "Src activation following P2Y purinoceptor activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25531", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35363", "l": "(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH = isopentadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66292", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781897", "l": "USP11 deubiquitinates NFKBIA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33144", "l": "galactitol(in) => galactitol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61408", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysine = ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18058", "l": "O2 + Watasenia luciferin => CO2 + hnu + oxidized Watasenia luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:1990760", "l": "osmolarity-sensing monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a monoatomic cation by a channel that opens when a change in the osmolarity occurs in the extracellular space of the cell in which the cation channel resides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.10.2", "l": "\"non-specific protein-tyrosine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73390", "l": "H(+)(in) + malonate(out) + phosphate(in) <=> H(+)(out) + malonate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19519", "l": "dimethylamine + formate => H2O + N,N-dimethylformamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73718", "l": "UBF-1 Binds rDNA Promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75074", "l": "chloride(out) + Cs(+)(in) + 2 hydrogencarbonate(in) <=> chloride(in) + Cs(+)(out) + 2 hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41809", "l": "(3R)-hydroxybutanoyl-[ACP] => (2E)-butenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354087", "l": "Recruitment of GRB2 to p-PTK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004468", "l": "lysine N-acetyltransferase activity, acting on acetyl phosphate as donor", "d": ["Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140550", "l": "phosphatidylinositol-4,5-bisphosphate sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of phosphatidylinositol-4,5-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33484", "l": "an acyl-CoA + ergosterol => CoA + ergosteryl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34433", "l": "(-)-lariciresinol + H(+) + NADPH => (+)-secoisolariciresinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18010", "l": "glutaryl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27475", "l": "ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+) => ATP + D-glycero-beta-D-manno-heptose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34504", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-epi-alpha-bisabolol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52728", "l": "3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate = a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052761", "l": "exo-1,4-beta-D-glucosaminidase activity", "d": ["Catalysis of the reaction: [beta-(1->4)-D-glucosamine]n-[N-acetyl-D-glucosamine]m = D-glucosamine + [beta-(1->4)-D-glucosamine](n-1)-[N-acetyl-D-glucosamine]m. This reaction is the hydrolysis of chitosan or chitosan oligosaccharides to remove a D-glucosamine residue from the non-reducing termini; chitosan is a linear polysaccharide composed of randomly distributed beta-(1->4)-linked D-glucosamine and N-acetyl-D-glucosamine units."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18335", "l": "ADP + H(+) + oleandomycin 2'-O-phosphate => ATP + oleandomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264615", "l": "Loading of acetylcholine in synaptic vesicles (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5681980", "l": "ATG12 binds ATG7 dimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73577", "l": "CAD hexamer transforms L-Gln to CAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28015", "l": "S-adenosyl-L-methionine + thiocyanate => methyl thiocyanate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2201341", "l": "Endocytosis of TRAM (TICAM2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592278", "l": "Autocatalytic activation of proMMP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17729", "l": "an acyl-CoA + cholesterol = a cholesterol ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879798", "l": "Expression of DEC1 (BHLHE40, BHLHB2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69005", "l": "Cdc6 protein is phosphorylated by CDK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71783", "l": "MDH2 reduces OA to MAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798743", "l": "Exocytosis of secretory granule membrane proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0038187", "l": "pattern recognition receptor activity", "d": ["Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432510", "l": "CLK is degraded by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64852", "l": "benzoyl-CoA + octan-1-ol = CoA + octyl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9681616", "l": "AP2 binds chlorpromazine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63162", "l": "(15Z)-tetracosenoate + taurine => H2O + N-(15Z-tetracosenoyl)-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134962", "l": "DHX36 binds DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30956", "l": "9,9'-di-cis-zeta-carotene + 2 a quinone => 7,7',9,9'-tetra-cis-lycopene + 2 a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17635", "l": "an alcohol + D-glucuronate => a beta-D-glucuronoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43500", "l": "beta-D-glucuronate + NAD(+) = D-glucaro-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912379", "l": "Transport of fringe-modified NOTCH to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39077", "l": "(3S)-hydroxydodecanedioyl-CoA => (2E)-dodecenedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50154", "l": "15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36016", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218906", "l": "RIPK3 phosphorylates MLKL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49017", "l": "aurachin C epoxide => 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.103", "l": "\"keratan-sulfate endo-1,4-beta-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189069", "l": "sucrose + H2O => glucose + fructose (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48055", "l": "n 3'-phosphoadenylyl sulfate + dermatan <=> n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3858489", "l": "ppDVL binds DAAM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018657", "l": "toluene 3-monooxygenase activity", "d": ["Catalysis of the reaction: toluene + 1/2 O2 = 3-hydroxytoluene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3159253", "l": "MMAB adenosylates cob(I)alamin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60931", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66736", "l": "ATP + beta-citrylglutamate(in) + H2O = ADP + beta-citrylglutamate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686578", "l": "Activated ATM phosphorylates ABL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.118", "l": "\"glucose 1-dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954117", "l": "E2F6:TFDP1 binds EPC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111970", "l": "PKC phosphorylates GRK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948757", "l": "AKT phosphorylates MKRN1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51212", "l": "(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18889", "l": "D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.15", "l": "\"alpha,alpha-trehalose-phosphate synthase (UDP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54781", "l": "[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine => [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56450", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005127", "l": "ciliary neurotrophic factor receptor binding", "d": ["Binding to a ciliary neurotrophic factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11112", "l": "H2O + isochorismate = (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate", "d": []}, {"i": "EC:3.3.2.1", "l": "\"isochorismatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66424", "l": "ATP + H2O + leukotriene B4(in) = ADP + H(+) + leukotriene B4(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047508", "l": "(R)-2-methylmalate dehydratase activity", "d": ["Catalysis of the reaction: (R)-citramalate = 2-methylmaleate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755572", "l": "Defective SRD5A3 does not reduce pPNOL to DCHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39590", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656250", "l": "Defective OGG1 mutants do not excise 8-oxoguanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53027", "l": "a plastoquinone + H2O + L-arginine <=> 5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48436", "l": "H2O + pentanoate ester = an aliphatic alcohol + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759186", "l": "AcK-NFE2L2- dependent NQO1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30557", "l": "GDP + H(+) + oxidized coenzyme F420-1 + phosphate => GTP + L-glutamate + oxidized coenzyme F420-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218824", "l": "p-6Y-VEGFR2 binds FYN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428522", "l": "Inactivation of RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211874", "l": "CYP2S1 4-hydroxylates atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54623", "l": "2-oxoglutarate + eicosanoyl-CoA + O2 <=> 2-hydroxyeicosanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430096", "l": "GP1b-IX-V binds filamin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.83", "l": "\"monoterpene epsilon-lactone hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74104", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39435", "l": "(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33421", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73172", "l": "adenosine 3',5'-bisphosphate(out) + NAD(+)(in) => adenosine 3',5'-bisphosphate(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112037", "l": "Inactivation of PLC beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975874", "l": "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31762", "l": "dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66451", "l": "(E)-pent-2-en-1-ol + NADP(+) <=> (E)-2-pentenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61323", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0030296", "l": "protein tyrosine kinase activator activity", "d": ["Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38806", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43867", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034948", "l": "2,6-dihydroxypseudooxynicotine hydrolase activity", "d": ["Catalysis of the reaction: 2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-methylaminobutyrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47729", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72604", "l": "(E)-sinapate + ATP + H(+) => (E)-sinapoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49978", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine => butanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389463", "l": "Proteinase-activated receptors can bind thrombin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16341", "l": "(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP", "d": []}, {"i": "EC:2.7.4.2", "l": "\"phosphomevalonate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30856", "l": "dammarenediol-II => (S)-2,3-epoxysqualene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27627", "l": "D-erythrose 4-phosphate + D-xylulose 5-phosphate => beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30576", "l": "3 menaquinone-8 + protoporphyrinogen IX => 3 menaquinol-8 + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26223", "l": "abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55009", "l": "(1R,4S)-1-hydroxylimonen-2-one + NADPH + O2 => (3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41019", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol = 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879594", "l": "SLCO4C1 mediates the transport of digoxin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9760402", "l": "ILF3 binds HOXC8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64825", "l": "1-naphthaleneacetamide + H2O => 1-naphthaleneacetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862184", "l": "USP48 cleaves polyubiquitin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9733969", "l": "Bile salts dissociate from FABP6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72223", "l": "4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out) = 4-hydroxy-L-proline + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47195", "l": "coenzyme M + methyl-Co(III)-[methylated-thiol-specific corrinoid protein] <=> Co(I)-[methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42264", "l": "H(+) + malonyl-[ACP] + octanoyl-CoA = 3-oxodecanoyl-[ACP] + CO2 + CoA", "d": []}, {"i": "EC:2.3.1.207", "l": "\"beta-ketodecanoyl-[acyl-carrier-protein] synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17579", "l": "ADP-L-glycero-beta-D-manno-heptose => ADP-D-glycero-beta-D-manno-heptose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805981", "l": "HMGB1 release from cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19324", "l": "N,N-dimethylaniline N-oxide <=> formaldehyde + N-methylaniline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15423", "l": "a long-chain fatty acyl-CoA + AMP + diphosphate => a long-chain fatty acid + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964284", "l": "BTK in active Gq-BTK complex is activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60879", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848110", "l": "SOCS3 binds activated PTK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38612", "l": "NAD(+) => cyclic ADP-beta-D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452091", "l": "Phosphorylation of IL2RB Y338 enables SHC recruitment (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693148", "l": "BCKDK phosphorylates BCKDH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390595", "l": "Calcium Binds Troponin-C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174171", "l": "Association of Cyclin A with the APC/C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32846", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.54", "l": "\"methylenetetrahydrofolate reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2467811", "l": "Separation of sister chromatids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43539", "l": "2 D-glyceraldehyde 3-phosphate <=> 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32369", "l": "4 Fe(II)-[cytochrome c] + 5 H(+) + L-dehydroascorbate => 4 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54006", "l": "(11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097657", "l": "3',5'-nucleotide bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: 3',5'-nucleoside bisphosphate + H20 = 5'-nucleoside monophosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43470", "l": "(8Z,10E,14Z)-12-hydroperoxyeicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41724", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3159253", "l": "MMAB adenosylates cob(I)alamin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450488", "l": "BRF1 Complex recruits RNA degradation activities (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42697", "l": "H2O + hercynylselenocysteine => NH4(+) + pyruvate + selnoneine thione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35276", "l": "3-hydroxyoctadecanoyl-CoA + NAD(+) => 3-oxooctadecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650710", "l": "Translation of PPP1R15A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68669", "l": "16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60815", "l": "2-oxoglutarate + gibberellin A12 aldehyde + O2 <=> CO2 + gibberellin A12 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37802", "l": "2 H(+) + 2 NADH + O2 <=> 2 H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379387", "l": "COMT transfers Met to DA to form 3MT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140332", "l": "lipopolysaccharide transfer activity", "d": ["Removes a lipopolysaccharide (LPS) from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648017", "l": "EML4 binds to microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879459", "l": "F-actin capping protein is a heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483186", "l": "PC is converted to PS by PTDSS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23256", "l": "adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine = adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate", "d": []}, {"i": "EC:6.3.5.10", "l": "\"adenosylcobyric acid synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801776", "l": "REG3A binds bacterial phospholipids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29544", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465940", "l": "atRAL is reduced to atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32442", "l": "(+)-epi-isozizaene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> albaflavenone + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53718", "l": "phosphate + UDP-N-acetyl-alpha-D-muramate => H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036310", "l": "ATP-dependent DNA/DNA annealing activity", "d": ["An ATP-dependent activity that facilitates the formation of a complementary double-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769394", "l": "AKT phosphorylates CBY1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016994", "l": "precorrin-6A reductase activity", "d": ["Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68617", "l": "cortisone + H(+) + NADPH => cortisol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617650", "l": "HOXD3 chromatin is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1013881", "l": "Cables1 links CDK2 and WEE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61972", "l": "1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112385", "l": "Addition of nucleotides leads to transcript elongation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56794", "l": "2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein] => 2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15886", "l": "NADP(+) + propane-1,2-diol => (S)-lactaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65589", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13978", "l": "D-serine => NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047871", "l": "disulfoglucosamine-6-sulfatase activity", "d": ["Catalysis of the reaction: N(2),6-disulfo-D-glucosamine + H2O = N-sulfo-D-glucosamine + H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018662", "l": "phenol 2-monooxygenase activity", "d": ["Catalysis of the reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34438", "l": "4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine <=> 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69233", "l": "(Z)-3-hydroxypropyl glucosinolate + H2O => (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336182", "l": "GPR37 binds prosaptide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430135", "l": "p-SLP-76 binds ADAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190263", "l": "FGFR3b binds to FGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70126", "l": "3-dehydro-6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 6-dehydro-28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453346", "l": "PYGB b dimer:AMP complex <=> PGYB dimer, b form + 2 AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65522", "l": "all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin] => all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-622310", "l": "Activated NOD1 oligomerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961907", "l": "E2F1 binds the CDC45 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56272", "l": "4 Fe(III)-[cytochrome cL] + H2O + methanol = 4 Fe(II)-[cytochrome cL] + formate + 5 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0051861", "l": "glycolipid binding", "d": ["Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4419986", "l": "Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41108", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O => 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666049", "l": "SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052589", "l": "malate dehydrogenase (menaquinone) activity", "d": ["Catalysis of the reaction: (S)-malate + a menaquinone = oxaloacetate + a menaquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29737", "l": "butanal + FMN + 2 H(+) + H2O + sulfite => butane-1-sulfonate + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948602", "l": "miR-19a microRNA binds CNOT6L mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662596", "l": "MT1F binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34052", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H2O => 6'''-deamino-6'''-hydroxyneomycin C + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49616", "l": "2-hydroxy-2-methylpropanal + H2O + NAD(+) = 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.98", "l": "\"2-hydroxy-2-methylpropanal dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710353", "l": "GSDMD (1-275) binds cardiolipin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983307", "l": "IL15 binds IL15RA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42017", "l": "cortisone + NAD(+) => 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32048", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => adenosine 5'-pentaphosphate + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229132", "l": "AP4 binds APP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.509227218911647", "identifiers": [{"i": "GO:0003899", "l": "DNA-directed 5'-3' RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14005", "l": "H2O + L,L-cystathionine = 2-oxobutanoate + L-cysteine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54252", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450466", "l": "AUF1:mRNA complex is destroyed (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5226999", "l": "ADD1:ADD3 binds DMTN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21982", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24901", "l": "2 GTP <=> 3',3'-c-di-GMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30405", "l": "Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in) => Fe(3+)(out) + L-ascorbate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67155", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein] <=> L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72780", "l": "chloride + FADH2 + O2 + ochratoxin B => FAD + 2 H2O + ochratoxin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61111", "l": "(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21855", "l": "(R)-10-hydroxyoctadecanoate <=> (9Z)-octadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538900", "l": "Phosphorylated PER rebinds to phosphorylated TIM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32276", "l": "4-(phosphooxy)-L-threonine + NAD(+) => 3-amino-2-oxopropyl phosphate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18773", "l": "coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid protein] = Co(I)-[methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611277", "l": "P2RY12 binds P2RY12 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002460", "l": "P4HB binds Collagen chains (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39555", "l": "3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69939", "l": "6-deoxotyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxytyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59844", "l": "(+)-dehydrodiconiferyl alcohol + H(+) + NADPH = (R)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57519", "l": "dolabradiene + O2 + reduced [NADPH--hemoprotein reductase] <=> 15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420977", "l": "Ca permeable AMPA receptor ligand binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67241", "l": "(R)-S-adenosyl-L-methionine + H2O => adenosine + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004162", "l": "dimethylnitrosamine demethylase activity", "d": ["Catalysis of the removal of a methyl group from N-nitrosodimethylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65980", "l": "hnu + previtamin D3 = tachysterol 3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25929", "l": "3-methylquinoline + A + H2O => 3-methylquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047011", "l": "2-dehydropantolactone reductase (A-specific) activity", "d": ["Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17713", "l": "(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine", "d": []}, {"i": "EC:1.14.19.67", "l": "\"salutaridine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044590", "l": "iron-sulfur-molybdenum cofactor binding", "d": ["Binding to iron molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46370", "l": "a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.2", "l": "\"pepsin B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050407", "l": "[glycogen-synthase-D] phosphatase activity", "d": ["Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853444", "l": "AURKA phosphorylates PHLDA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44741", "l": "27-O-demethylrifamycin SV + S-adenosyl-L-methionine => H(+) + rifamycin SV + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55128", "l": "(3R)-hydroxy-5-methylhexanoyl-[ACP] = (2E)-5-methylhexenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71893", "l": "H(+) + N(2)-(ADP-D-ribosyl)-dGMP + nicotinamide => dGMP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807077", "l": "NR2E1 associated with transcription repressors binds PTEN promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55465", "l": "11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] => 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199154", "l": "CD200 binds to CD200R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36785", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine => L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684836", "l": "CLEC1B dimer binds PDPN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20094", "l": "an anthocyanidin + H(+) + UDP-alpha-D-glucose => an anthocyanidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72382", "l": "chloride(out) + iodide(in) <=> chloride(in) + iodide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787820", "l": "IL34 dimer binds CSF1R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59795", "l": "H2O + NADP(+) + yersinopine <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38762", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102596", "l": "cytochrome P450 dependent ent-sandaracopimaradiene 3-hydroxylase activity", "d": ["Catalysis of the reaction: ent-sandaracopimara-8(14),15-diene + NADPH + H+ + O2 <=> ent-sandaracopimaradien-3beta-ol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983700", "l": "SYK binds the activated BCR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76104", "l": "(11R)-carlactonoate + S-adenosyl-L-methionine => (11R)-methyl carlactonoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44313", "l": "1-tetradecanoylglycerol + H2O => glycerol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-167429", "l": "The receptor:G-protein complex  binds GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712088", "l": "ALK fusion proteins bind IRS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.415093686714229", "identifiers": [{"i": "GO:0016832", "l": "aldehyde-lyase activity", "d": ["Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072373", "l": "alpha-carotene epsilon hydroxylase activity", "d": ["Catalysis of the reaction: alpha-carotene + NADPH + O2 + H+ = alpha-cryptoxanthin + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0017069", "l": "snRNA binding", "d": ["Binding to a small nuclear RNA (snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168858", "l": "Palmitoylation of cysteine residues on HA in the cis-Golgi network (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19532", "l": "isovitexin + UDP-alpha-D-glucose <=> H(+) + isovitexin 2''-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70537", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + GDP + H(+) => GDP-beta-L-fucose + L-seryl-[EGF-like domain protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41723", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15655", "l": "ADP + beta-D-fructose 2,6-bisphosphate + H(+) => ATP + beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44387", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA <=> 1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75577", "l": "11-O-acetylcyathin A3 + AH2 => 11-O-acetylcyathatriol + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850945", "l": "Casein kinase II phosphorylates PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59842", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate => (6S)-5,6,7,8-tetrahydrofolate + syringate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2106625", "l": "Duplex siRNA is loaded into Argonaute (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858428", "l": "FCAMR binds IgA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47157", "l": "7alpha,25-dihydroxycholesterol + NAD(+) => 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31557", "l": "(3S)-3-aminobutanoyl-CoA + acetoacetate => (5S)-5-amino-3-oxohexanoate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37130", "l": "2-oxoglutarate + dioxidophosphate + H2O2 <=> CO2 + H(+) + phosphonate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24263", "l": "(3E)-2-oxohex-3-enedioate + H(+) <=> 2-oxopent-4-enoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61320", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71172", "l": "H(+)(in) + L-cysteine(out) + Na(+)(out) => H(+)(out) + L-cysteine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50225", "l": "3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0051536", "l": "iron-sulfur cluster binding", "d": ["Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1861789", "l": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67494", "l": "a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+) => a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56331", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O <=> 5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209910", "l": "Iodide is taken up by thyroid epithelial cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71627", "l": "phosphate(in) + succinate(out) = phosphate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0016406", "l": "carnitine O-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19215", "l": "an N-acetyl-L-cysteine-S-conjugate + CoA + H(+) => acetyl-CoA + an S-substituted L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21525", "l": "3-methyl-2-oxobutanoate + acetyl-CoA + H2O => (2S)-2-isopropylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20861", "l": "(1S,6R)-isopiperitenol + NAD(+) => (6R)-isopiperitenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611851", "l": "ADRB2 bind ADR,NAd (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40699", "l": "1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol = 1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37044", "l": "ATP + H2O + L-alanyl-L-glutamate(out) => ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047907", "l": "furylfuramide isomerase activity", "d": ["Catalysis of the reaction: (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30237", "l": "2 H(+) + L-glutamate + NADH => H2O + L-glutamate 5-semialdehyde + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0043208", "l": "glycosphingolipid binding", "d": ["Binding to glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805109", "l": "CDK2 phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28721", "l": "adenine(out) + H(+)(out) => adenine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047552", "l": "2-oxoaldehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo acid + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52992", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine = [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40480", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30807", "l": "L-pipecolate + NAD(+) = Delta(1)-piperideine-2-carboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63591", "l": "prunetin + UDP-alpha-D-glucuronate <=> prunetin-4'-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139918", "l": "Phosphorylation of BIM by JNK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65412", "l": "dAMP(in) + NAD(+)(out) = dAMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56093", "l": "bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19789", "l": "4-(dimethylamino)azobenzene + H2O + NADP(+) = 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH", "d": []}, {"i": "EC:1.7.1.11", "l": "\"4-(dimethylamino)phenylazoxybenzene reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39617", "l": "(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043035", "l": "chromatin insulator sequence binding", "d": ["Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693111", "l": "RHOF auto-activates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047783", "l": "corticosterone 18-monooxygenase activity", "d": ["Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73165", "l": "FAD(in) + NAD(+)(out) => FAD(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024726", "l": "LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59131", "l": "(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP <=> 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9703895", "l": "CASR binds CASR agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45211", "l": "coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein] <=> Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72742", "l": "chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out) <=> chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.55", "l": "\"caspase-2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2430535", "l": "MASTL phosphorylates ENSA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63894", "l": "AMP + D-tryptophan + diphosphate + H(+) => ATP + H2O + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873946", "l": "OTUD3 deubiquitinates PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.55", "l": "\"4-hydroxybenzoate brominase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390598", "l": "Myosin Binds ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446634", "l": "IRAK4 is activated by autophosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8948757", "l": "AKT phosphorylates MKRN1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008463", "l": "formylmethionine deformylase activity", "d": ["Catalysis of the reaction: N-formyl-L-methionine + H2O = L-methionine + formate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904483", "l": "synthetic cannabinoid binding", "d": ["Binding to synthetic cannabinoid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49487", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31724", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] => (2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50244", "l": "17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.64", "l": "\"2,6-beta-fructan 6-levanbiohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44087", "l": "ATP + CoA + heptadecanoate <=> AMP + diphosphate + heptadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9732729", "l": "Activated JAK1 binds RAF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72341", "l": "catechol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + guaiacol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59650", "l": "D-xylotrionate + H(+) => D-xylotriono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672083", "l": "KTN1 binds Kinesin-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58521", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.18", "l": "\"malonate-semialdehyde dehydrogenase (acetylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25731", "l": "H(+) + N,N-dihydroxy-L-tetrahomomethionine = (E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676599", "l": "sBAFF trimer binds BAFFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35333", "l": "(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH => (S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102726", "l": "DIMBOA glucoside beta-D-glucosidase activity", "d": ["Catalysis of the reaction: (2R)-DIMBOA glucoside + H2O = H+ + DIMBOA + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73572", "l": "(E,E)-piperate + ATP + CoA => (E,E)-piperoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.38", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610722", "l": "CK1 phosphorylates p-GLI3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392263", "l": "AVP(20-28) binds AVPR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74465", "l": "4'-methoxyviridicatin + H(+) + methyl isocyanate => (-)-4'-methoxycyclopenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227769", "l": "TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22317", "l": "13-hydroxydocosanoate + UDP-alpha-D-glucose => 13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71932", "l": "fumarate(out) + 3 Na(+)(out) => fumarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64649", "l": "(E)-coniferaldehyde + CoA + NADP(+) => (E)-feruloyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22906", "l": "gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467775", "l": "Autocleavage of ESPL1 (Separase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110156", "l": "UNG glycosylase mediated recognition and binding of an uracil opposite to a guanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53246", "l": "cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31796", "l": "(+)-(E)-beta-caryophyllene + H2O => (+)-caryolan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72014", "l": "glutathione(in) + urate(out) <=> glutathione(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35059", "l": "chloramphenicol(in) + H(+)(out) = chloramphenicol(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33995", "l": "gamma-L-glutamyl-butirosin B = 5-oxo-L-proline + butirosin B", "d": []}, {"i": "EC:4.3.2.6", "l": "\"gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30607", "l": "A + all-trans-phytofluene = AH2 + all-trans-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951727", "l": "cAMP binds PKA tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45173", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16979", "l": "2-oxopropyl-coenzyme M + CO2 + NADPH => acetoacetate + coenzyme M + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25671", "l": "sucrose + UDP-alpha-D-galactose => H(+) + loliose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609746", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN2B (GRIN2B) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47702", "l": "H2O + iso-precytochalasin + NADP(+) => H(+) + ketocytochalasin + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32994", "l": "2 a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709454", "l": "EPOR binds EPOR agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58043", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57404", "l": "NAD(+) + narcotine hemiacetal = H(+) + NADH + noscapine", "d": []}, {"i": "EC:1.1.1.415", "l": "\"noscapine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69068", "l": "RFC dissociates after sliding clamp formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72989", "l": "myo-inositol(in) + 2 Na(+)(in) => myo-inositol(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196929", "l": "FLAD1 phosphorylates FMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177284", "l": "PKA phosphorylates PDE4B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39366", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA <=> (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17263", "l": "a phenol + H(+) + sulfate => an aryl sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0033328", "l": "peroxisome membrane targeting sequence binding", "d": ["Binding to a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28396", "l": "L-alanyl-D-glutamate => L-alanyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810376", "l": "ING2 binds PI5P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52021", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 => A + H2O + resolvin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54521", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => cycloaraneosene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35889", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202168", "l": "Phosphorylation of ZAP-70 by Lck (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709547", "l": "ESTG binds ESR2:chaperone complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21959", "l": "UDP-alpha-D-glucose + vitexin <=> H(+) + UDP + vitexin 2''-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23455", "l": "2'-deoxyadenosine + ATP <=> ADP + dAMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43618", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43334", "l": "2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36551", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol = 3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28771", "l": "(2E)-hexadecenoyl-CoA = (9Z)-hexadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419389", "l": "LPA-binding receptors bind LPA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0016890", "l": "site-specific endodeoxyribonuclease activity, specific for altered base", "d": ["Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks."]}, {"i": "EC:3.1.25.-", "l": "\"Site-specific endodeoxyribonucleases specific for altered bases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654514", "l": "KAL1 binds FGFR1c (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444572", "l": "Zinc is an agonist of GPR39 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50530", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047560", "l": "3-dehydrosphinganine reductase activity", "d": ["Catalysis of the reaction: NADP+ + sphinganine = 3-dehydrosphinganine + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35709", "l": "(3S)-versiconol acetate + H2O + NADP(+) => (2S)-versicolorone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2129357", "l": "Fibrillin C-terminal processing (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16287", "l": "H(+) + L-arginine + NADH + pyruvate => D-octopine + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606288", "l": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34542", "l": "S-adenosyl-L-methionine + tellurite <=> methanetellurite + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374723", "l": "Nociceptin receptor binds to nociceptin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467775", "l": "Autocleavage of ESPL1 (Separase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61514", "l": "malvidin 3-O-beta-D-glucoside + UDP => malvidin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266350", "l": "CETP-mediated lipid exchange: LDL gains cholesterol ester (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68425", "l": "(3R)-3-hydroxy-10'-apo-beta-carotenal + O2 => (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50673", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O => [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25967", "l": "(R)-benzoin + NADP(+) <=> benzil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630053", "l": "NTHL1 D239Y does not cleave thymine glycol (Tg) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618107", "l": "ATP binding to HSP90 triggers conformation change (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50336", "l": "O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate = H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36818", "l": "dTDP-alpha-D-fucose <=> dTDP-alpha-D-fucofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46901", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) => a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32877", "l": "a fatty acid + glycerol + H(+) => a 1-acyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341294", "l": "Superoxide reduces cytochrome c (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74058", "l": "D-cysteine(out) + L-alanine(in) <=> D-cysteine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052684", "l": "L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity", "d": ["Catalysis of the reaction: indole + L-serine = L-tryptophan + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44732", "l": "2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009485", "l": "IL34:CSF1 binds CSF1R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24762", "l": "3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+) => H(+) + L-dopa + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59614", "l": "beta-alanine + L-ornithine => beta-alanyl-L-ornithine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46426", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55120", "l": "4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43934", "l": "androst-5-ene-3,17-dione + H(+) + NADH => 3beta-hydroxyandrost-5-en-17-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70241", "l": "PCK1 phosphorylates OA to yield PEP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55247", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4beta-methylzymosterol-4alpha-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691421", "l": "BTK binds BTK inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36095", "l": "S-adenosyl-L-methionine + salicylate = methyl salicylate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.274", "l": "\"salicylate carboxymethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53438", "l": "19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801762", "l": "REG3A oligomerize to form a pore complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39458", "l": "(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427570", "l": "Group 3 - Selective Cl- transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635842", "l": "ULK3 phosphorylates GLI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47885", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70241", "l": "an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside => a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62811", "l": "H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52129", "l": "a 5'-end adenosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O => a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047032", "l": "3-alpha-hydroxyglycyrrhetinate dehydrogenase activity", "d": ["Catalysis of the reaction: 3alpha-hydroxyglycyrrhetinate + NADP+ = 3-oxoglycyrrhetinate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687388", "l": "SARS-CoV-1 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419003", "l": "Interaction of Nectins with Afadin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65151", "l": "phloretin + UDP-alpha-D-glucose <=> H(+) + trilobatin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59746", "l": "CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein] => (9Z)-octadecenoyl-CoA + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218811", "l": "DOCK180:ELMO binds CRK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57733", "l": "A + all-trans-7,8-dihydroretinol => AH2 + all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17798", "l": "[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose => [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028526", "l": "NR1H2 or NR1H3, NRIP1 bind the SCD gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156678", "l": "Activation of Cdc25C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43170", "l": "inosine(34) in tRNA + NH4(+) => adenosine(34) in tRNA + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036427", "l": "all-trans-undecaprenyl-phosphate mannosyltransferase activity", "d": ["Catalysis of the reaction: all-trans-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate + GDP."]}, {"i": "RHEA:28118", "l": "di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193703", "l": "IKKbeta is activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67759", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36351", "l": "AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.253", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48227", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O <=> a neolactoside nLc4Cer(d18:1(4E)) + L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51568", "l": "(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944483", "l": "miR-17 microRNA binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41584", "l": "dimethylallyl diphosphate + L-tyrosine = 4-O-dimethylallyl-L-tyrosine + diphosphate", "d": []}, {"i": "EC:2.5.1.122", "l": "\"4-O-dimethylallyl-L-tyrosine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41342", "l": "10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate => (6Z,9Z,12Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62089", "l": "D-glucosamine 6-phosphate + NADP(+) => 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637765", "l": "Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57095", "l": "AH2 + S-(methylsulfanyl)glutathione <=> A + glutathione + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74294", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate <=> an alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019779", "l": "Atg8 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58071", "l": "(E)-isoeugenol + O2 <=> acetaldehyde + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757574", "l": "ALB binds PREDL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40611", "l": "H2O + trihexanoylglycerol = 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452750", "l": "Expression of FOXD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69461", "l": "[thioredoxin]-dithiol + arsenic triglutathione + 2 H2O + S-adenosyl-L-methionine => [thioredoxin]-disulfide + 3 glutathione + H(+) + methylarsonous acid + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374251", "l": "DARC  is a non-specific receptor for many chemokines (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48488", "l": "all-trans-retinol--[retinol-binding protein] + NAD(+) = all-trans-retinal--[retinol-binding protein] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990175", "l": "EH domain binding", "d": ["Binding to an EH domain of a protein. The EH stand for Eps15 homology. This was originally identified as a motif present in three copies at the NH2-termini of Eps15 and of the related molecule Eps15R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36005", "l": "propanal + pyruvate => (S)-4-hydroxy-2-oxohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34666", "l": "20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371591", "l": "Trimerization of cytosolic HSF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38088", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49810", "l": "a quinol + butanal => a quinone + butan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37499", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.26", "l": "\"peptide-tryptophan 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0097509", "l": "oxanine DNA N-glycosylase activity", "d": ["DNA N-glycosylase activity acting on deaminated guanine where the resulting base (oxanine) is generated by NO- or HNO2-induced nitrosative deamination."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37503", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60758", "l": "cinerin I + CoA => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203774", "l": "Interaction of Csk with PAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705467", "l": "SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391934", "l": "DP2 receptor can bind PGD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25546", "l": "diphosphate + ent-pimara-9(11),15-diene => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007447", "l": "E2F6 forms the PRC1L4 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42869", "l": "norspermine + S-adenosyl 3-(methylsulfanyl)propylamine => caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17617", "l": "leukotriene C4 = glutathione + leukotriene A4", "d": []}, {"i": "EC:4.4.1.20", "l": "\"leukotriene-C4 synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5333671", "l": "CLCAs self cleave (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74147", "l": "(S)-2-benzoylsuccinyl-CoA + CoA = benzoyl-CoA + succinyl-CoA", "d": []}, {"i": "EC:2.3.1.310", "l": "\"benzoylsuccinyl-CoA thiolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40355", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19904", "l": "L-tryptophan + O2 <=> alpha,beta-didehydrotryptophan + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69618", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55807", "l": "(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351849", "l": "Caspase-mediated cleavage of Etk (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65651", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine <=> a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28973", "l": "H(+)(out) + shikimate(out) => H(+)(in) + shikimate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56765", "l": "12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 => 12-epi-fischerindole G + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802921", "l": "Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044682", "l": "archaeal-specific GTP cyclohydrolase activity", "d": ["Catalysis of the reaction: GTP + H2O = 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate +formate + H+. This activity is part of the biosynthesis of methanopterin in Archaea, and requires Fe2+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11945", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12986", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203977", "l": "SAR1 Activation And Membrane Binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51299", "l": "a quinone + H2O + L-methionyl-[protein] <=> a quinol + L-methionyl-(R)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73618", "l": "CTP(out) + dCMP(in) <=> CTP(in) + dCMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33902", "l": "FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose <=> FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.224", "l": "\"violacein synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28729", "l": "Cu(2+)(out) + H(+)(out) => Cu(2+)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551297", "l": "Defective ALG11 does not transfer Man to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018774", "l": "RHOBTB1 binds GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58086", "l": "(13Z)-docosenoate + glycerol + H(+) => 1-(13Z-docosenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25212", "l": "H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine <=> acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30805", "l": "4-aminobutanoate + 2 H(+) + NADPH => 4-aminobutanal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75788", "l": "GTP(in) => GTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9604308", "l": "NICD4 traffics to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53574", "l": "20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67942", "l": "2-oxooctanoate + H2O2 => 2-hydroxyoctanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69258", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+) => H2O + progoitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75623", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate = 14-oxo-15-hydroxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.843050782660015", "identifiers": [{"i": "GO:0022829", "l": "wide pore channel activity", "d": ["Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10183", "l": "(6S)-10-formyltetrahydrofolate + H2O + NADP(+) <=> (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045503", "l": "dynein light chain binding", "d": ["Binding to a light chain of the dynein complex."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036478", "l": "L-dopa decarboxylase activator activity", "d": ["Interacts with and increases L-dopa decarboxylase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483087", "l": "PI is exchanged with PC by PITPNB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614790", "l": "EGR2, SOX10 and SMARCA4 bind the MPZ gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3928620", "l": "PAK1 autophosphorylates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110453", "l": "Phosphorylation of PIP2 to PIP3 by Dp110 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047164", "l": "isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase activity", "d": ["Catalysis of the reaction: biochanin-A + malonyl-CoA = 6'-malonyl-biochanin A + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60075", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 <=> 4beta-hydroxymethyl-4alpha-methylzymosterol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49132", "l": "an adenosine in tRNA + S-adenosyl-L-methionine = an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68265", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O => (6S)-5,6,7,8-tetrahydrofolate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60866", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50144", "l": "ethyl (9Z)-hexadecenoate + H2O = (9Z)-hexadecenoate + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30190", "l": "(S)-dihydroorotate + a quinone <=> a quinol + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22976", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34186", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose <=> alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11875", "l": "corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9621179", "l": "Cinaciguat binds sGC:NO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.59", "l": "\"juvenile-hormone esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451895", "l": "IL2RG binds JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451482", "l": "activated MEK2 binds ERK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047272", "l": "phosphopolyprenol glucosyltransferase activity", "d": ["Catalysis of the reaction: polyprenyl phosphate + UDP-D-glucose = polyprenylphosphate-glucose + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37585", "l": "6-amino-2-oxohexanoate + H2O2 + NH4(+) => D-lysine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25031", "l": "ADP-D-ribose + phosphate => ADP-alpha-D-ribose 1''-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35416", "l": "an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose => an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9037612", "l": "H antigen-sec translocates from Golgi lumen to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12874", "l": "(R)-2-hydroxy-4-methylpentanoate + NADP(+) => 4-methyl-2-oxopentanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66384", "l": "(2E,6E,10E,14E)-geranylfarnesol = scalar-17(25)-en-19-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39000", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O => a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042300", "l": "beta-amyrin synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693148", "l": "BCKDK phosphorylates BCKDH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59200", "l": "ATP + docosanoate + H(+) = diphosphate + docosanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73173", "l": "adenosine 3',5'-bisphosphate(in) + NAD(+)(out) => adenosine 3',5'-bisphosphate(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877153", "l": "STARD7 binds PC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30658", "l": "ATP + dUMP <=> ADP + dUDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45177", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74167", "l": "H2O + N,N-dimethylglycine + oxidized 2[4Fe-4S]-[ferredoxin] = formaldehyde + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19303", "l": "H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine => histamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37402", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30476", "l": "H2O + oroxylin A 7-O-beta-D-glucuronate => D-glucuronate + H(+) + oroxylin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72995", "l": "L-fucose(out) + 2 Na(+)(out) = L-fucose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798044", "l": "BTG2 binds CCR4-NOT complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57352", "l": "O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin = H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806831", "l": "CYB5Rs reduce MetHb to HbA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71714", "l": "H(+)(out) + L-tyrosylglycine(out) <=> H(+)(in) + L-tyrosylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15114", "l": "5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O => 5alpha-cholestane-3beta,5,6beta-triol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218824", "l": "p-6Y-VEGFR2 binds FYN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44624", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.384", "l": "\"dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0015368", "l": "calcium:monoatomic cation antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in)."]}, {"i": "REACT:R-HSA-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16458", "l": "(2R,3S)-tartrate + NAD(+) => 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50247", "l": "17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33420", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53706", "l": "H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine => 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42687", "l": "gamma-L-glutamyl-hercynylcysteine S-oxide + H2O <=> L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29322", "l": "H2O + sn-glycero-3-phosphoethanolamine <=> ethanolamine + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70846", "l": "L-arginine(in) + L-methionine(out) + Na(+)(out) <=> L-arginine(out) + L-methionine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629918", "l": "NEIL1 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54206", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099038", "l": "ceramide floppase activity", "d": ["Catalysis of the movement of ceramide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.323", "l": "\"(+)-thujan-3-ol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65714", "l": "beta-L-galactose 1-phosphate + GDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + GDP-beta-L-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19617", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38778", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901691", "l": "proton binding", "d": ["Binding to proton."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61680", "l": "ATP + holo-[peptidyl-carrier protein] + L-cysteine = AMP + diphosphate + L-cysteinyl-[peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.69", "l": "\"L-cysteine--[L-cysteinyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174097", "l": "Association of Emi1 with Cdh1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730904", "l": "Auto-ubiquitination of TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16730", "l": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) => catechol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71603", "l": "2-oxoglutarate(out) + oxaloacetate(in) = 2-oxoglutarate(in) + oxaloacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46539", "l": "(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034256", "l": "chlorophyll(ide) b reductase activity", "d": ["Catalysis of the reaction: 71-hydroxychlorophyll(ide) a + NAD(P)+ = chlorophyll(ide) b + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4647594", "l": "SAHF formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013488", "l": "HEYL gene expression is stimulated by NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55426", "l": "(3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69663", "l": "H2O + luteolin 7-O-beta-D-glucoside = beta-D-glucose + luteolin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005459", "l": "UDP-galactose transmembrane transporter activity", "d": ["Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41194", "l": "1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74687", "l": "a 2,3-di-O-phytanyl-sn-glycerophospholipid + AH2 + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + A + a macrocyclic archaeaol phospholipid + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37383", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693061", "l": "STAMBP binds STAM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400267", "l": "BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66021", "l": "H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen] => [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102144", "l": "carboxyspermidine dehydrogenase II activity", "d": ["Catalysis of the reaction: carboxyspermidine + H2O + NADP <=> L-aspartic acid 4-semialdehyde betaine + 1,4-butanediammonium + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31576", "l": "8-oxo-dGTP + H2O => 8-oxo-dGMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60406", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23143", "l": "beta-nicotinamide D-ribonucleotide + H2O <=> D-ribose 5-phosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1912369", "l": "NOTCH precursor cleaved to form mature NOTCH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58946", "l": "7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+) => 6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656244", "l": "DRD2 binds DA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63285", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446694", "l": "IRAK4 phosphorylates IRAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018640", "l": "dibenzothiophene monooxygenase activity", "d": ["Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53175", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31113", "l": "3-oxohexanoyl-CoA + CoA => acetyl-CoA + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15093", "l": "2-oxoglutarate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50545", "l": "prostaglandin C2 => prostaglandin B2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10696", "l": "a long-chain fatty acid + ATP + holo-[mycocerosate synthase] = AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase]", "d": []}, {"i": "EC:6.2.1.49", "l": "\"long-chain fatty acid adenylyltransferase FadD28\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22564", "l": "a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72672", "l": "The 60S subunit joins the translation initiation complex  (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62696", "l": "O2 + 4 tellimagrandin II = 2 cornusiin E + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635854", "l": "GLI2,3 are degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47334", "l": "16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12474", "l": "ethylamine + glyoxylate + H2O2 => H2O + N-ethylglycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74101", "l": "ADP + H(+) + L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71836", "l": "estrone 3-sulfate(out) => estrone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564143", "l": "Collagen type X degradation by MMP1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871266", "l": "YAP1 binds TEAD3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72353", "l": "glutarate(out) + glycocholate(in) => glutarate(in) + glycocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635839", "l": "ULK3:SUFU dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25331", "l": "(R)-carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57215", "l": "dGTP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64886", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.23", "l": "\"nitroarene dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54423", "l": "3',3'-c-di-AMP + H2O <=> 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19050", "l": "(5R)-5-hydroxy-L-lysine + GTP => (5R)-5-phosphooxy-L-lysine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26557", "l": "angiotensin II + H2O <=> angiotensin-(1-7) + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090566", "l": "protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N,N'-diacetylchitobiose(out) = protein cysteine + N,N'-diacetylchitobiose phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54253", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5615668", "l": "AKR1C3 reduces atRAL to atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050586", "l": "3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-methylquinolin-4(1H)-one + H+ + O2 = N-acetylanthranilate + CO."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59075", "l": "AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984606", "l": "Kinesin-5 is a homotetramer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372529", "l": "Release of acetylcholine at the synapse (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804276", "l": "ATM phosphorylates TTC5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26427", "l": "ATP + H2O + L-glutamine + UTP => ADP + CTP + 2 H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.77", "l": "\"snapalysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28906", "l": "D-alanine(in) + H(+)(in) <=> D-alanine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35021", "l": "L-threonine(out) => L-threonine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72403", "l": "2-oxoglutarate(out) + urate(in) = 2-oxoglutarate(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45187", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+) <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63195", "l": "[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 <=> glycine betaine + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63373", "l": "an acyl-CoA + L-cysteinyl-[protein] => an S-acyl-L-cysteinyl-[protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42672", "l": "gamma-L-glutamyl-L-cysteine + hercynine + O2 = gamma-L-glutamyl-hercynylcysteine S-oxide + H2O", "d": []}, {"i": "EC:1.14.99.50", "l": "\"gamma-glutamyl hercynylcysteine S-oxide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13797", "l": "a dolichyl phosphate + H2O = di-trans,poly-cis-dolichol + phosphate", "d": []}, {"i": "EC:3.1.3.51", "l": "\"dolichyl-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47470", "l": "(3E,5Z)-tetradecadienoyl-CoA => (2E,4E)-tetradecadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15343", "l": "ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate => ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426150", "l": "SREBP1A,1C,2 binds the HMGCS1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3132759", "l": "TCN1 binds RCbl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703430", "l": "FLT3 fusions:GRB2 bind SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9770141", "l": "Formation of the Spliceosomal C* complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68313", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O => 1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75548", "l": "2 (3R)-3-isocyanylbutanoyl-[ACP] + ATP + L-lysine + 2 NADPH => (2S)-2,6-bis[(3R)-3-isocyanobutanamido]hexan-1-ol + AMP + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16462", "l": "ATP + H2O + urate(in) => ADP + H(+) + phosphate + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201717", "l": "CSNK2-mediated phosphorylation of DVL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9667914", "l": "ALK binds ligand midkine (MDK) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9006850", "l": "IL21 receptor JAK phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.253913141376358", "identifiers": [{"i": "GO:0042562", "l": "hormone binding", "d": ["Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33214", "l": "1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-7 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18965", "l": "hydroxymethylbilane = H2O + uroporphyrinogen III", "d": []}, {"i": "EC:4.2.1.75", "l": "\"uroporphyrinogen-III synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66121", "l": "2-oxobutanoate + L-methionine => (2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58623", "l": "N-decanoyl-(2S)-hydroxyglycine <=> decanamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.9", "l": "\"N-acylglucosamine-6-phosphate 2-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74820", "l": "glutathione(in) => glutathione(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657665", "l": "ALKBH2 binds alkylated dsDNA containing 3-meC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46399", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an (11E)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.226136141113301", "identifiers": [{"i": "GO:0001653", "l": "peptide receptor activity", "d": ["Combining with an extracellular or intracellular peptide to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68395", "l": "H2O + peracetic acid <=> acetate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102330", "l": "palmitoyl-[acp] elongase/decarboxylase activity", "d": ["Catalysis of the reaction: malonyl-CoA + a palmitoyl-[acp] = 1-heptadecene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21421", "l": "NADP(+) + prostaglandin I2 => 15-dehydro-prostaglandin I2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.182", "l": "\"lipid-A-disaccharide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10001", "l": "H2O + pentanamide => NH4(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10848", "l": "an [alpha-factor](in) + ATP + H2O = ADP + an [alpha-factor](out) + H(+) + phosphate", "d": []}, {"i": "EC:7.4.2.7", "l": "\"ABC-type alpha-factor-pheromone transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52960", "l": "hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399712", "l": "Activation of Ca permeable AMPA receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10298", "l": "(2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH => D-glyceraldehyde 3-phosphate + NADP(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753634", "l": "GGT dimers hydrolyse APAP-SG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52176", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21637", "l": "(E)-4-coumarate + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612243", "l": "APOE gene transcription is stimulated by ERBB4s80 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38146", "l": "carbon disulfide + 2 H2O <=> CO2 + 2 H(+) + 2 hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799332", "l": "ATR phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49405", "l": "beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate => alpha-D-mannose 1-phosphate + D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51929", "l": "H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) => (S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004877", "l": "complement component C3b receptor activity", "d": ["Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050181", "l": "phorbol-diester hydrolase activity", "d": ["Catalysis of the reaction: H2O + phorbol 12,13-dibutanoate = butanoate + H+ + phorbol 13-butanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67611", "l": "H2O + N(6)-methyl-ATP <=> diphosphate + H(+) + N(6)-methyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55697", "l": "a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O => an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675790", "l": "MTORC1 dissociates from ULK complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19435", "l": "6-phospho-D-gluconate + ADP + H(+) => ATP + D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61603", "l": "[DsbD protein]-disulfide + [protein]-dithiol <=> [DsbB protein]-dithiol + [protein]-disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67752", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351876", "l": "Caspase-mediated cleavage of occludin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2545253", "l": "Deacetylation of cohesin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44854", "l": "CoA + O-(5Z)-tetradecenoyl-(R)-carnitine => (5Z)-tetradecenoyl-CoA + (R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-171106", "l": "LDLR:LDL complex => LDLR + LDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661184", "l": "Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399942", "l": "Plexin-A1-4 binds NRP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618004", "l": "FOXO:SMAD complex binds CDKN1A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0034483", "l": "heparan sulfate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68681", "l": "3'-phosphoadenylyl sulfate + 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(beta-D-glucuronate) => 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5604929", "l": "Activated protein C binds Protein S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61643", "l": "H(+) + isophthalyl-CoA <=> benzoyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72015", "l": "acetyl-CoA + 2 AH2 + 9 H(+) + malate + 6 malonyl-CoA + 5 NADPH + 2 S-adenosyl-L-methionine = 2 A + 6 CO2 + 7 CoA + 6 H2O + 5 NADP(+) + 2 S-adenosyl-L-homocysteine + trihazone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62057", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0015199", "l": "amino-acid betaine transmembrane transporter activity", "d": ["Enables the transfer of betaine from one side of a membrane to the other. Betaine is the N-trimethyl derivative of an amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22740", "l": "ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050046", "l": "delta7-sterol 5(6)-desaturase activity", "d": ["Catalysis of the reaction: a delta(7)-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ -> a delta(5,7)-sterol + 2 ferricytochrome b5 + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9817575", "l": "ERO1B oxidizes P4HB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635859", "l": "GLI:SUFU dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56308", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.54", "l": "\"1,2-dehydroreticuline synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011543", "l": "DCA binds PDK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008684", "l": "TBK1 phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5624948", "l": "KIF17 enters the cilium (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847880", "l": "CYTH proteins bind ARF1:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72946", "l": "2 Na(+)(out) + pyruvate(out) <=> 2 Na(+)(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.28", "l": "\"tropomyosin kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34111", "l": "carboxyspermidine + H2O + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793564", "l": "Cipro HCl dissolves (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9828175", "l": "Formation of the NSL complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18276", "l": "H2O + O2 + putrescine <=> 4-aminobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59282", "l": "D-asparagine => L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54132", "l": "a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate = a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371422", "l": "ATP hydrolysis by HSP70 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354097", "l": "Activation of Talin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0071617", "l": "lysophospholipid acyltransferase activity", "d": ["Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34016", "l": "ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 => ergosterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30697", "l": "beta-alanine + 2 H(+) + NADH => 3-aminopropanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022065", "l": "DSPGs are secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73797", "l": "FAICAR => IMP + H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46159", "l": "15,9'-di-cis-phytofluene + a plastoquinone <=> 9,9',15-tri-cis-zeta-carotene + a plastoquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806732", "l": "GNLY binds the bacterial cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65128", "l": "1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12451", "l": "(R)-pantothenate + H2O <=> (R)-pantoate + beta-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.24", "l": "\"tocopherol cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0052713", "l": "inositol phosphorylceramide phospholipase activity", "d": ["Catalysis of the reaction: inositol phosphorylceramide + H2O = C26-phytoceramide + phosphorylinositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41341", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 => 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013438", "l": "RHOD binds effectors at the endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20009", "l": "2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose = H(+) + linamarin + UDP", "d": []}, {"i": "EC:2.4.1.63", "l": "\"linamarin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53597", "l": "1-octadecanoyl-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31248", "l": "H(+) + prop-2-ynal + pyrroloquinoline quinol => prop-2-yn-1-ol + pyrroloquinoline quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784189", "l": "JAKs bind LIFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295599", "l": "SPRY2 translocates to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9707505", "l": "Hemes bind to CLEC1B dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20615", "l": "adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine => 3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44966", "l": "dodecanoyl-CoA + NADP(+) => (2E)-dodecenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615348", "l": "AGT(34-41) binds to AGTR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58334", "l": "(E)-non-2-enal + H(+) + NADPH => (E)-non-2-en-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9676254", "l": "Formation of the MLL3 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58838", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759158", "l": "SQSTM1 oligomerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70241", "l": "PCK1 phosphorylates OA to yield PEP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37539", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864361", "l": "KCTD15 binds TFAP2 homo- and heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11532", "l": "glycine + H2O + O2 = glyoxylate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427337", "l": "MBD2 binds methylcytosine in chromatin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40812", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73326", "l": "(2R,3S)-piscidate + (E)-caffeoyl-CoA <=> cimicifugate D + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5252001", "l": "ATP1B4 binds SNW1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28158", "l": "alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55200", "l": "5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine", "d": []}, {"i": "EC:2.5.1.147", "l": "\"5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607736", "l": "MALT1 oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73244", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether => cirsimaritin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50713", "l": "chloride + FADH2 + O2 + tetracycline => 7-chlorotetracycline + FAD + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69237", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate => 4-hydroxybutylnitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25590", "l": "(S)-oxalosuccinate + H(+) + NADPH => D-threo-isocitrate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917987", "l": "TFRC dimer binds 2xholoTF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.2.-", "l": "\"With ascorbate as one donor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39215", "l": "(2E)-hexacosenoyl-CoA + H(+) + NADPH = hexacosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749609", "l": "BCHE hydrolyzes ASA- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549322", "l": "OCT1 transports organic cations out of hepatic cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18014", "l": "H2O + N(5)-ethyl-L-glutamine => ethylamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22813", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) => 5,10-methenyltetrahydrofolate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.24", "l": "\"1,4-alpha-glucan 6-alpha-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202325", "l": "Recruitment of Gads to LAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814778", "l": "GDPD3 hydrolyzes LysoPtdCho (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73800", "l": "SAICAR => AICAR + Fumarate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38586", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28773", "l": "(9Z)-hexadecenoyl-CoA => (2E)-hexadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229283", "l": "LCNs bind lipids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21991", "l": "malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside <=> 4'''-demalonylsalvianin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.4", "l": "\"Gly-Xaa carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050248", "l": "Renilla-luciferin 2-monooxygenase activity", "d": ["Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050535", "l": "beta-primeverosidase activity", "d": ["Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50861", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016920", "l": "pyroglutamyl-peptidase activity", "d": ["Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33000", "l": "(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675417", "l": "PEBP1 binds activated RAF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53406", "l": "13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004574", "l": "oligo-1,6-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10211", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) <=> H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426569", "l": "Interaction of DAP12 and IREM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21565", "l": "acetyl-CoA + an acyl-CoA => a 3-oxoacyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781941", "l": "WNTs are secreted in exosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n14", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018532", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity", "d": ["Catalysis of the reaction: N5,N10-methenyltetrahydromethanopterin + H2 = N5,N10-methylenetetrahydromethanopterin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49731", "l": "2 H(+) + NADPH + 2 O2 + protoviolaceinate <=> CO2 + 2 H2O + NADP(+) + violacein", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010945", "l": "CoA pyrophosphatase activity", "d": ["Catalysis of the reaction: coenzyme A or its derivatives + H2O = 3',5'-ADP + 4'-phosphopantetheine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59572", "l": "H2O + L-homocarnosine = 4-aminobutanoate + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31499", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.275", "l": "\"neolactotriaosylceramide beta-1,4-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63688", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11251", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59299", "l": "an N-acylglycine + 2 L-ascorbate + O2 <=> an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42203", "l": "corticosterone + NADP(+) <=> 11-dehydrocorticosterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170704", "l": "Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41745", "l": "3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40067", "l": "2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O = 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45530", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2167876", "l": "SMAD7:SMURF2 complex translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76069", "l": "(S)-cis-N-methyl-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-homocysteine => (S)-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.124", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8866851", "l": "CFTR transits to the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983144", "l": "Transport of Antigen peptide in to ER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32129", "l": "cis-4-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + L-proline + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33977", "l": "D-glucose + DIMBOA => DIMBOA beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11407", "l": "UDP-alpha-D-glucuronate <=> UDP-alpha-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34498", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71709", "l": "H(+)(in) + L-phenylalanyl-L-phenylalanine(in) => H(+)(out) + L-phenylalanyl-L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73330", "l": "(2R,3S)-piscidate + (E)-sinapoyl-CoA <=> cimicifugate J + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.314", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204871", "l": "Interaction of Tie2 and Grb2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47194", "l": "Co(I)-[methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[methylated-thiol-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164500", "l": "Conformational changes in gp120 exposes gp41 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849646", "l": "SPINK5(490-624) binds KLK5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51476", "l": "a ribonucleoside 5'-triphosphate + formate + H(+) = a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O", "d": []}, {"i": "EC:1.1.98.6", "l": "\"ribonucleoside-triphosphate reductase (formate)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31303", "l": "a reduced flavin + NAD(+) = an oxidized flavin + 2 H(+) + NADH", "d": []}, {"i": "EC:1.5.1.36", "l": "\"flavin reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53204", "l": "17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] = 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41884", "l": "dodecanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32599", "l": "7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = 3-isopropenyl-6-oxoheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28958", "l": "aldehydo-D-glucuronate(in) + H(+)(in) <=> aldehydo-D-glucuronate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59461", "l": "hexadecan-1-ol + NADP(+) => H(+) + hexadecanal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982645", "l": "GRKs bind ADRB2:Catecholamine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27588", "l": "indole-3-pyruvate + L-alanine => L-tryptophan + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0034593", "l": "phosphatidylinositol bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15999", "l": "2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+) => anthraniloyl-CoA + 2 H(+) + 2 NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "61.140992638571788", "identifiers": [{"i": "GO:0004672", "l": "protein kinase activity", "d": ["Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192051", "l": "CYP7A1 7-hydroxylates CHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0005200", "l": "structural constituent of cytoskeleton", "d": ["The action of a molecule that contributes to the structural integrity of a cytoskeletal structure."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41293", "l": "dodecanoate + sphing-4-enine => H2O + N-dodecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654159", "l": "Activated FGFR2 binds PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48689", "l": "H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine => D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23702", "l": "(6S)-10-formyltetrahydrofolate + H(+) => 5,10-methenyltetrahydrofolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75046", "l": "L-cystine(out) + L-leucine(in) <=> L-cystine(in) + L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66180", "l": "ATP + bilirubin-glucuronoside(in) + H2O = ADP + bilirubin-glucuronoside(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54391", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.74", "l": "\"methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))-methyltransferase [NAD(P)H-oxidizing]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23877", "l": "protoaphin aglucone => H2O + xanthoaphin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35860", "l": "1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672011", "l": "p-AMPK:AMP binds the ULK complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64585", "l": "2-hydroxyethane-1-sulfonate(out) + Na(+)(out) => 2-hydroxyethane-1-sulfonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55757", "l": "2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 => a 2-hydroxyornithine lipid + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69074", "l": "(5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+) => H2O + O2 + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31991", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + sesquithujene", "d": []}, {"i": "EC:4.2.3.102", "l": "\"sesquithujene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58242", "l": "ADP-D-ribose + L-cysteinyl-[protein] => H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11812", "l": "H2O + methanethiol + O2 = formaldehyde + H(+) + H2O2 + hydrogen sulfide", "d": []}, {"i": "EC:1.8.3.4", "l": "\"methanethiol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036136", "l": "kynurenine-oxaloacetate transaminase activity", "d": ["Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41955", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate <=> [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2219524", "l": "PDPK1 binds PIP2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27347", "l": "5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+) => FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72531", "l": "ATP + H2O + methyl beta-D-galactoside(out) = ADP + H(+) + methyl beta-D-galactoside(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69068", "l": "RFC dissociates after sliding clamp formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202510", "l": "Activation of TAK1-TAB2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666001", "l": "Profilin:G-actin binds MKL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38919", "l": "H2O + sphing-4-enine-phosphocholine = choline + H(+) + sphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14172", "l": "ATP + CoA + glutarate <=> ADP + glutaryl-CoA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73187", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate = (2R,3S,11R)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794356", "l": "BEGAIN binds DLG2,DLG3,DLG4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38501", "l": "a 2,3-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863973", "l": "Fusion of ERC and phagosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047334", "l": "diphosphate-fructose-6-phosphate 1-phosphotransferase activity", "d": ["Catalysis of the reaction: fructose-6-phosphate + diphosphate = phosphate + fructose-1,6-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111264", "l": "Addition of nucleotides between position +11 and +30 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209108", "l": "Membrane-bound GISH binds to ARR receptor complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61529", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base => a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336184", "l": "GPR37L binds prosaposin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5681987", "l": "LC3 is cleaved by ATG4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399712", "l": "Activation of Ca permeable AMPA receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170149", "l": "Translocation of active Cdc25C to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59711", "l": "D-maltotriono-1,5-lactone + H2O <=> D-maltotrionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54795", "l": "L-histidyl-[protein] + N(7)-methyl-GTP <=> diphosphate + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17212", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O <=> 2-formylglutarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19521", "l": "acetyl-CoA + phosphate = acetyl phosphate + CoA", "d": []}, {"i": "EC:2.3.1.8", "l": "\"phosphate acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21362", "l": "diphosphate + NAD(+) => ATP + beta-nicotinamide D-ribonucleotide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43101", "l": "S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) => 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47656", "l": "acetyl-CoA + L-methionine sulfone = CoA + H(+) + N-acetyl-L-methionine sulfone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473594", "l": "Collagen type II degradation by MMP15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38052", "l": "2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA => 1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38601", "l": "nicotinamide + nicotinate-adenine dinucleotide phosphate => NADP(+) + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53006", "l": "2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140897", "l": "mechanoreceptor activity", "d": ["Combining with a mechanical force and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10720", "l": "2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione", "d": []}, {"i": "EC:1.5.4.1", "l": "\"pyrimidodiazepine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50879", "l": "a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH <=> a hydroxy polyunsaturated fatty acid + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873926", "l": "IFNG dimer binds IFNGR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46824", "l": "4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36171", "l": "a 1-acylglycerone 3-phosphate + a long chain fatty alcohol = 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)", "d": []}, {"i": "EC:2.5.1.26", "l": "\"alkylglycerone-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004967", "l": "glucagon receptor activity", "d": ["Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-481009", "l": "Exocytosis of platelet dense granule content (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47807", "l": "epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159868", "l": "Furin cleaves pro-factor VII to factor VII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15368", "l": "3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose <=> 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38511", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168046", "l": "Collagen type XII degradation by MMP12 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047880", "l": "erythrulose reductase activity", "d": ["Catalysis of the reaction: D-threitol + NADP+ = D-erythrulose + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47596", "l": "an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.335", "l": "\"dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653974", "l": "Ragulator binds Rag dimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954056", "l": "E2F6 binds TFDP2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33569", "l": "acetaldehyde + AH2 => A + ethanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15875", "l": "[(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+) => [(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22783", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170159", "l": "Translocation of Cdc25 to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49527", "l": "2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 <=> a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57013", "l": "a menaquinone + H2O + sulfite => a menaquinol + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950504", "l": "IL27 binds CRLF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45504", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27489", "l": "2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate", "d": []}, {"i": "EC:5.3.1.28", "l": "\"D-sedoheptulose-7-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018767", "l": "2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + isobutyrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40828", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849055", "l": "PTK6 binds ARHGAP35 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-378952", "l": "Thyrotropin is a heterodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43441", "l": "hexadecanoate + sphinganine => H2O + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951644", "l": "Release of mature NEDD8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.124", "l": "\"2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60834", "l": "a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate => a 5'-end triphospho-guanosine in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26046", "l": "acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-9-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25475", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-himachalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72136", "l": "putrescine(out) => putrescine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43141", "l": "guanosine(26) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004856", "l": "xylulokinase activity", "d": ["Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61276", "l": "H2O + L-ornithine + O2 = 5-amino-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35751", "l": "ATP + kanosamine = ADP + D-kanosamine 6-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.179", "l": "\"kanosamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39655", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951727", "l": "cAMP binds PKA tetramer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021520", "l": "NOTCH3 binds WWP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434650", "l": "MATEs mediate extrusion of xenobiotics (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687107", "l": "MAPK4,6 translocate to nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34630", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73998", "l": "geranylgeranyl diphosphate + H2O <=> (S)-(+)-nephthenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3215406", "l": "PRMT5 binds WDR77 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134962", "l": "DHX36 binds DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56489", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40734", "l": "(20S)-ginsenoside Rg3 + 2 H2O <=> (20S)-protopanaxadiol + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213246", "l": "Disassociation of CLIP from MHC II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26341", "l": "L-selenocysteine + S-methyl-L-methionine = H(+) + L-methionine + Se-methyl-L-selenocysteine", "d": []}, {"i": "EC:2.1.1.280", "l": "\"selenocysteine Se-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733973", "l": "Bile salts bind FABP6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.139", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36025", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0038182", "l": "G protein-coupled bile acid receptor activity", "d": ["Combining with an extracellular bile acid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985343", "l": "RUNX2 binds SOX9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.119", "l": "\"glucose 1-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371422", "l": "ATP hydrolysis by HSP70 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64622", "l": "(E)-sinapoyl actetate + CoA => (E)-sinapyl alcohol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32202", "l": "androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62442", "l": "4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1) => [(1->4)-alpha-D-galacturonosyl methyl ester](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60561", "l": "L-methionyl-[protein] + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114254", "l": "CYCS binds to APAF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48977", "l": "5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 => CO2 + H2O + NAD(+) + pyocyanin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.3.6", "l": "\"aureusidin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672158", "l": "GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68363", "l": "L-xylono-1,4-lactone + O2 <=> dehydro-L-arabinono-1,4-lactone + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49111", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine <=> 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420265", "l": "AMY1-3 bind IAPP(34-70) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69731", "l": "CoA + phenylacetyl-AMP = AMP + H(+) + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46254", "l": "a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38949", "l": "12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918232", "l": "Recruitment of IRF3,IRF7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9760402", "l": "ILF3 binds HOXC8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73728", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate => (2S,3R,11R)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66135", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56982", "l": "4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin] => 4-hydroxybenzyl alcohol + 2 oxidized [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32103", "l": "2 S-adenosyl-L-methionine + trans-resveratrol = 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.240", "l": "\"trans-resveratrol di-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193964", "l": "CYP21A2 21-hydroxylates PROG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38307", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21060", "l": "3,4-dichloroaniline + malonyl-CoA = CoA + N-(3,4-dichlorophenyl)malonamate", "d": []}, {"i": "EC:2.3.1.114", "l": "\"3,4-dichloroaniline N-malonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203700", "l": "eNOS translocation from Golgi to Caveolae (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10469", "l": "D-xylulose 5-phosphate + phosphate => acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166041", "l": "Transfer of LPS onto TLR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035273", "l": "phthalate binding", "d": ["Binding to a phthalate, any ester or salt of phthalic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71469", "l": "L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7) => H2O + substance P", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0009922", "l": "fatty acid elongase activity", "d": ["Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer with an additional 2-C unit). This reaction is the condensation step of the endoplasmic reticulum fatty acid elongation cycle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45549", "l": "phycourobilin-L-cysteinyl(84)-[R-phycocyanin alpha-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[R-phycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46077", "l": "(2E)-eicosenoyl-CoA + H(+) + NADH => eicosanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55372", "l": "H2O + methyl (-)-jasmonate = H(+) + jasmonate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252072", "l": "AZGP1 binds PIP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67460", "l": "(R)-malate + A = AH2 + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43860", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912389", "l": "Formation of axial/lateral elements of Synaptonemal Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69658", "l": "H2O + quercetin 3-O-beta-D-glucoside <=> beta-D-glucose + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67571", "l": "3'-phosphoadenylyl sulfate + taurochenodeoxycholate <=> adenosine 3',5'-bisphosphate + H(+) + taurochenodeoxycholate 7-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75243", "l": "acetyl-CoA + N-terminal L-leucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-leucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000327", "l": "PLK1 phosphorylates BORA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.16", "l": "\"HIV-1 retropepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617458", "l": "HOXA1 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641206", "l": "RSPOs bind LGRs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690449", "l": "S1PR1 bind S1P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047753", "l": "choline-sulfatase activity", "d": ["Catalysis of the reaction: choline sulfate + H2O = choline + H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77068", "l": "Activation of GT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873921", "l": "Binding of STAT1 to p-IFNGR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109858", "l": "MAP2K2 binds MAPK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27985", "l": "7-carboxy-7-deazaguanine + ATP + NH4(+) <=> 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042610", "l": "CD8 receptor binding", "d": ["Binding to a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14850", "l": "H2O + N-amidino-L-aspartate => L-aspartate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51264", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] = (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937989", "l": "RUNX1 binds PRC1 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28046", "l": "phosphate + propanoyl-CoA = CoA + propanoyl phosphate", "d": []}, {"i": "EC:2.3.1.222", "l": "\"phosphate propanoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44330", "l": "glycerol + H(+) + octanoate => 1-octanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75891", "l": "Abortive Initiation After Second Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647660", "l": "GSDME (1-270) binds PIPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28370", "l": "oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate", "d": []}, {"i": "EC:4.1.1.31", "l": "\"phosphoenolpyruvate carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11064", "l": "beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate", "d": []}, {"i": "EC:3.1.3.11", "l": "\"fructose-bisphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69715", "l": "(indol-3-yl)acetate + ATP + CoA = (indol-3-yl)acetyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.75", "l": "\"indoleacetate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428625", "l": "Vesicular inhibitory amino acid transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9017491", "l": "RHOJ GEFs activate RHOJ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004653", "l": "polypeptide N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42446", "l": "H(+) + iminosuccinate + NADPH => L-aspartate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034528", "l": "2-carboxy-2-hydroxy-8-carboxychromene isomerase activity", "d": ["Catalysis of the reaction: 2-carboxy-2-hydroxy-8-carboxychromene = 2-hydroxy-3-carboxybenzalpyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176956", "l": "Formation of GINS complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37375", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857686", "l": "FITM1, FITM2 bind TAGs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25629", "l": "myricetin + S-adenosyl-L-methionine = H(+) + laricitrin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69319", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate <=> allyl thiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560804", "l": "Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19375", "l": "2-oxoglutarate + H(+) + L-lysine + NADPH => H2O + L-saccharopine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707523", "l": "Hemes bind to BACH1:MAFK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102837", "l": "1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27744", "l": "2-deoxy-alpha-D-ribose 1-phosphate + adenine => 2'-deoxyadenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29736", "l": "butane-1-sulfonate + FMNH2 + O2 => butanal + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10607", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005157", "l": "macrophage colony-stimulating factor receptor binding", "d": ["Binding to a macrophage colony-stimulating factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21791", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47823", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14570", "l": "propane-1,2-diol => H2O + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990464", "l": "D-2-hydroxyacid dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: (R)-2-hydroxyacid + a quinone = 2-oxoacid + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49389", "l": "UDP-alpha-D-glucose + validoxylamine A => H(+) + UDP + validamycin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72011", "l": "glutathione(in) + urate(out) = glutathione(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21657", "l": "CDP-alpha-D-paratose => CDP-3,6-dideoxy-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48948", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36531", "l": "(13Z)-docosenoyl-CoA + H(+) + malonyl-CoA = (15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46751", "l": "carboxyphosphate + NH4(+) <=> carbamate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876258", "l": "CBL monoubiquitinates InlB-bound MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50026", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine => dodecanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63594", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2106614", "l": "Duplex miRNA is loaded into Argonaute (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56641", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65760", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11393", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O => 1D-myo-inositol 1,3,4-trisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32395", "l": "(1S,2S,4S)-dihydrocarveol + NAD(+) = (1S,4S)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27970", "l": "D-maltotriose + H2O = alpha-D-glucose + D-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58565", "l": "15alpha-stemmadenine + NADP(+) => 15alpha-stemmadenine intermediate II + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64412", "l": "H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) = H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46174", "l": "AMP + butanoyl-CoA + diphosphate => ATP + butanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614461", "l": "Tetramerization of procollagen VI (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043754", "l": "dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity", "d": ["Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72513", "l": "(R)-carnitine(in) + 2-oxoglutarate(out) => (R)-carnitine(out) + 2-oxoglutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666001", "l": "Profilin:G-actin binds MKL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36080", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine => a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38097", "l": "alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine => gamma-tocotrienol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39223", "l": "(3R)-hydroxyoctacosanoyl-CoA = (2E)-octacosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69940", "l": "6-deoxotyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxytyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45225", "l": "(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA => (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030741", "l": "inositol 1-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-1-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694409", "l": "Nucleotide exchange on RAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55750", "l": "coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin] => coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875374", "l": "MET binds LRIG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936851", "l": "AHRR binds ARNT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18201", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa", "d": []}, {"i": "EC:1.14.16.2", "l": "\"tyrosine 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679145", "l": "Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33253", "l": "6-kestotriose + beta-D-glucose => 2 sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029476", "l": "Role of myosins in phagosome formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61799", "l": "holo-[peptidyl-carrier protein] + L-tryptophyl-5'-AMP <=> AMP + L-tryptophyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46061", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43993", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 => 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.25", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004496", "l": "mevalonate kinase activity", "d": ["Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22026", "l": "2 H(+) + NADH + trimethylamine N-oxide => H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607744", "l": "MALT1 binds BCL10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53164", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247960", "l": "Activation of p38 MAPK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682626", "l": "nsp13 binds nsp12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679029", "l": "C-ter TLR7 dimer binds HCQ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47218", "l": "6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37202", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11259", "l": "H2O + limonin + UDP-alpha-D-glucose <=> glucosyl-limonin + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12371", "l": "2-dehydro-D-gluconate + A <=> 2,5-didehydro-D-gluconate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51350", "l": "10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine => acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50512", "l": "acetyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35489", "l": "2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45308", "l": "H(+) + NADPH + prostaglandin D2-ethanolamide = 11beta-prostaglandin F2-ethanolamide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48186", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4551648", "l": "SUMOylation of TDG with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46716", "l": "pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.11.1.-", "l": "\"Acting on carbon-phosphorus bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432428", "l": "Cytosolic CRY is degraded by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48598", "l": "decanoate + decanoylglycerol + H(+) => 1,2-didecanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810843", "l": "Envoplakin binds periplakin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25875", "l": "H2O2 + pyridine <=> H2O + pyridine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603784", "l": "PEX19:class I PMP binds PEX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49981", "l": "H2O + hexanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164508", "l": "N and C terminal heptad repeat helices of gp41 form six-helix bundle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22985", "l": "carbamoyl phosphate + oxamate => N-carbamoyl-2-oxoglycine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35490", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61090", "l": "(2R,3R)-dihydroquercetin + CO2 + succinate => (S)-eriodictyol + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72185", "l": "mRNA polyadenylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166753", "l": "Conversion of C4 into C4a and C4b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17973", "l": "diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24841", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49942", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.25", "l": "\"saccharopepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73385", "l": "thiamine diphosphate(out) + thiamine phosphate(in) => thiamine diphosphate(in) + thiamine phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54655", "l": "peregrinol diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806610", "l": "Keratin filament formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9656244", "l": "DRD2 binds DA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22168", "l": "UDP-alpha-D-glucose = UDP-alpha-D-galactose", "d": []}, {"i": "EC:5.1.3.2", "l": "\"UDP-glucose 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050225", "l": "pseudouridine kinase activity", "d": ["Catalysis of the reaction: ATP + pseudouridine = ADP + 2 H+ + pseudouridine 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052591", "l": "sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31307", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}, {"i": "EC:2.4.1.265", "l": "\"dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102757", "l": "NADPH phosphatase activity", "d": ["Catalysis of the reaction: NADPH + H2O = NADH + hydrogenphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213208", "l": "Type X collagen associates with collagen type II fibrils (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36721", "l": "CoA + H(+) + N-hexacosenoylsphinganine => hexacosenoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2530445", "l": "CD59 inhibits MAC formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.50", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193997", "l": "CYP11B1 oxidises 11DCORT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65973", "l": "a peptide antigen(in) + ATP + H2O => a peptide antigen(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.42903515889401", "identifiers": [{"i": "GO:0000987", "l": "cis-regulatory region sequence-specific DNA binding", "d": ["Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. The proximal promoter is in cis with and relatively close to the core promoter."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66244", "l": "ATP + H(+) + IC-asc-C9 = diphosphate + IC-asc-C9-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21381", "l": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA => AMP + diphosphate + phytanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975111", "l": "TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9   (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0030021", "l": "extracellular matrix structural constituent conferring compression resistance", "d": ["A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2214351", "l": "PLK1 phosphorylates GORASP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204863", "l": "Interaction of Tie2 with Ang2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801666", "l": "PLK2 phosphorylates CENPJ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168923", "l": "Collagen type XVIII endostatin release (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63291", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134962", "l": "DHX36 binds DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "57.107562012355025", "identifiers": [{"i": "GO:0097159", "l": "organic cyclic compound binding", "d": ["Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161789", "l": "15S-HETE is oxidised to 15-oxoETE by 15-HEDH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977238", "l": "Activated TLR5/TLR15 homodimer recruits MyD88 adaptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102833", "l": "sequoyitol galactinol:D-galactosylononitol galactosyltransferase activity", "d": ["Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + alpha-D-galactosyl-(1->3)-1D-myo-inositol <=> D-galactosylononitol + myo-inositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821931", "l": "BOD1L1 binds SET1A complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031815", "l": "P2Y5 nucleotide receptor binding", "d": ["Binding to a P2Y5 nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051737", "l": "GTP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: GTP + 5'-dephospho-DNA = GDP + 5'-phospho-DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17662", "l": "ATP + CoA + succinate => ADP + phosphate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.13", "l": "\"protein kinase C\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688456", "l": "MLKL binds FLOT1, FLOT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.274502573267668", "identifiers": [{"i": "GO:0016278", "l": "lysine N-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67892", "l": "3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine = 3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66027", "l": "hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen] <=> [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50777", "l": "hexanal + NADP(+) => (E)-hex-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139906", "l": "Activation of BAD by calcineurin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73268", "l": "H(+)(out) + L-methionine(in) => H(+)(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878054", "l": "HIPK2 phosphorylates RUNX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22000", "l": "D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.8.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369114", "l": "PRLR binds SHP2 (PTPN11) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52989", "l": "[deoxyhypusine synthase]-L-lysine + dehydrospermidine => [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23334", "l": "(2R)-3-phospho-glyceroyl phosphate + GDP => (2R)-3-phosphoglycerate + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654774", "l": "Transcription of PPP1R15A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190065", "l": "Activated TrkA receptor internalizes to endosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62836", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33539", "l": "ergosteryl ester + H2O = a carboxylate + ergosterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45845", "l": "(3R)-hydroxyoctanoyl-CoA + NADP(+) => 3-oxooctanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74374", "l": "a carboxylate(out) + nicotinate(in) <=> a carboxylate(in) + nicotinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24420", "l": "H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]", "d": []}, {"i": "EC:3.5.1.88", "l": "\"peptide deformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004764", "l": "shikimate 3-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018667", "l": "cyclohexanone monooxygenase activity", "d": ["Catalysis of the reaction: cyclohexanone + NADPH + H+ + O2 = 6-hexanolide + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46959", "l": "hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.39", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59289", "l": "beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O => D-glucose + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72912", "l": "proatranorin III + S-adenosyl-L-methionine => atranorin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139941", "l": "Binding of IP3 to IP3 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25838", "l": "5-deoxy-D-glucuronate + H(+) => 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55194", "l": "2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methyldodecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24273", "l": "H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 => H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70317", "l": "cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine => beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47276", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42819", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol <=> cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72581", "l": "(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA => (22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046555", "l": "acetylxylan esterase activity", "d": ["Catalysis of the deacetylation of xylans and xylo-oligosaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45618", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine => H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75986", "l": "(indol-3-yl)acetate(out) + a dicarboxylate(in) <=> (indol-3-yl)acetate(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9650165", "l": "ASIC trimers bind H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52101", "l": "5-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848606", "l": "PTK6 phosphorylates PXN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684006", "l": "KPNA2 translocates NBN to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176517", "l": "SULTs transfer (SO4)2- group to PREG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50933", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20519", "l": "UDP-N-acetyl-alpha-D-galactosamine => UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72505", "l": "glutarate(out) + prostaglandin F2alpha(in) => glutarate(in) + prostaglandin F2alpha(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201611", "l": "Caspase-mediated cleavage of Rock-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71312", "l": "chloride(out) + L-alanine(out) + 2 Na(+)(out) => chloride(in) + L-alanine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17492", "l": "H(+) + NADH + O2 + phthalate <=> cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59087", "l": "2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose <=> 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212352", "l": "Formation of ARC coactivator complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29199", "l": "(S)-dihydroorotate + menaquinone-8 = menaquinol-8 + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-606287", "l": "RSF complex binds the centromere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66834", "l": "diphosphate + preasperterpenoid A => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36161", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin] => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110218", "l": "Cleavage of uracil by TDG glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008887", "l": "glycerate kinase activity", "d": ["Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73289", "l": "(2S)-naringenin 4'-methyl ether + H(+) + S-adenosyl-L-homocysteine => (2S)-naringenin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250217", "l": "ARL2:GTP binds ARL2BP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443831", "l": "14-3-3-zeta binds Raf1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17282", "l": "(2S)-4-acetamido-2-aminobutanoate => H2O + L-ectoine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51066", "l": "adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate => 3'-phosphoadenylyl sulfate + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54938", "l": "decanoyl-[ACP] + NAD(+) => (2E)-decenoyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60171", "l": "a fatty acid + ATP <=> a fatty acyl monophosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32271", "l": "(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH", "d": []}, {"i": "EC:1.1.1.85", "l": "\"3-isopropylmalate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21368", "l": "H2O + O2 + urate = 5-hydroxyisourate + H2O2", "d": []}, {"i": "EC:1.7.3.3", "l": "\"factor independent urate hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141367", "l": "Myristoylation of tBID by NMT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165195", "l": "GTP loading by Rheb (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47609", "l": "3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57261", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP => GDP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59061", "l": "(20S)-ginsenoside Rg3 + H2O => (20S)-ginsenoside Rh2 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0004058", "l": "aromatic-L-amino-acid decarboxylase activity", "d": ["Catalysis of the reaction: L-amino acid + H+ = R-H + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950183", "l": "IL12B binds IL23A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917839", "l": "apo-Transferrin dissociates from the receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034084", "l": "steryl deacetylase activity", "d": ["Catalysis of the hydrolysis of an acetyl group or groups from an acetylated sterol."]}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0004689", "l": "phosphorylase kinase activity", "d": ["Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51661", "l": "an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 => an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32195", "l": "abieta-7,13-dien-18,18-diol = abieta-7,13-dien-18-al + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12827", "l": "[thioredoxin]-dithiol + H(+) + phosphate + sarcosine => [thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753634", "l": "GGT dimers hydrolyse APAP-SG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9761344", "l": "USP18 binds IKBKG within IKK complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191299", "l": "Squalene is oxidized to its epoxide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22400", "l": "androstan-3alpha,17beta-diol + NAD(+) = 17beta-hydroxyandrostanone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940959", "l": "Neurolysin degrades neurotensin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371590", "l": "HSP70 binds to HSP40:nascent protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800797", "l": "The PIDDosome activates CASP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.307", "l": "\"D-xylose reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9717841", "l": "holo-FDPS dimer binds NBPs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61462", "l": "a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in RNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47830", "l": "ganglioside GD1b + N-acetylneuraminate => ganglioside GT1b + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0019870", "l": "potassium channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a potassium channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51119", "l": "guanosine(6) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73345", "l": "AMP + beta-alanyl-[peptidyl-carrier protein] + H(+) => beta-alanyl-5'-AMP + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047650", "l": "alkylglycerone kinase activity", "d": ["Catalysis of the reaction: O-alkylglycerone + ATP = O-alkylglycerone phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58936", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH = all-trans-lycopaoctaene + 2 diphosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.63", "l": "\"caspase-10\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613476", "l": "EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5195402", "l": "CDK1 phosphorylates LPIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46305", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23946", "l": "4-O-(beta-D-glucosyl)-trans-coniferol + H(+) + UDP => (E)-coniferol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28401", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate <=> L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74457", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0140587", "l": "chromatin loop anchoring activity", "d": ["Bridging together two DNA loop anchors together, maintaining a chromatin loop."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46935", "l": "2-epi-5-epi-valiolone 7-phosphate <=> 5-epi-valiolone 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36364", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH => (9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60526", "l": "5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => 5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17889", "l": "H2O + phosphoethanolamine = acetaldehyde + NH4(+) + phosphate", "d": []}, {"i": "EC:4.2.3.2", "l": "\"ethanolamine-phosphate phospho-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851298", "l": "GPR143 binds L-Dopa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046574", "l": "glycuronidase activity", "d": ["Catalysis of the hydrolysis of glucuronosides, yielding free glucuronic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16632", "l": "(S)-malyl-CoA <=> acetyl-CoA + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48171", "l": "H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine <=> N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169683", "l": "IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21162", "l": "ATP + citrate + CoA => acetyl-CoA + ADP + oxaloacetate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10046", "l": "cyclohexanone + H(+) + NADH => cyclohexanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74781", "l": "3,3'-O-dimethylmyricetin + H(+) + S-adenosyl-L-homocysteine => laricitrin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32644", "l": "2 Fe(III)-[cytochrome c] + H2O + lupanine => 17-hydroxylupanine + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46700", "l": "(R)-lipoate + GTP + H(+) = (R)-lipoyl-GMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610720", "l": "PKA phosphorylates GLI3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700168", "l": "Active ALK phosphorylates IRS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60427", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + valerianol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73159", "l": "FMN(out) + NAD(+)(in) = FMN(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71743", "l": "2-oxoglutarate(out) + hexanedioate(in) = 2-oxoglutarate(in) + hexanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048249", "l": "high-affinity phosphate transmembrane transporter activity", "d": ["Enables the transfer of phosphate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379867", "l": "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013284", "l": "NOTCH3-ligand complex is cleaved to produce NEXT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53372", "l": "5,6-dihydrouridine(17) in tRNA + NAD(+) = H(+) + NADH + uridine(17) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.10", "l": "\"ribonuclease IX\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611839", "l": "β3-agonists bind ADRB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005176", "l": "ErbB-2 class receptor binding", "d": ["Binding to a protein-tyrosine kinase receptor Neu/ErbB-2/HER2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047513", "l": "1,2-alpha-L-fucosidase activity", "d": ["Catalysis of the reaction: H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59039", "l": "4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69631", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17511", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+) => H2O + thiamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24771", "l": "7(1)-hydroxychlorophyllide a + NAD(+) <=> chlorophyllide b + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50312", "l": "2-oxopentanoate + H(+) = butanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74734", "l": "Re-integration of insulin receptor into plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72000", "l": "O2 + preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + preaspterpenacid acid II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34648", "l": "S-adenosyl-L-methionine + squalene => 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68008", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (2E,6E,10E)-geranylgeranyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72655", "l": "1-hydroxy-6-methoxyphenazine + NADPH + O2 = 1-hydroxy-6-methoxyphenazine N(10)-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662706", "l": "Dopachrome transforms to DHI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70692", "l": "ornithine => putrescine + CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49504", "l": "phosphinomethylmalate = phosphinomethylisomalate", "d": []}, {"i": "EC:4.2.1.166", "l": "\"phosphinomethylmalate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35550", "l": "cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72122", "l": "(R)-carnitine(in) + glycine betaine(out) <=> (R)-carnitine(out) + glycine betaine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71112", "l": "L-phenylalanine(out) + S-methylmercury-L-cysteine(in) => L-phenylalanine(in) + S-methylmercury-L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042881", "l": "D-galactonate transmembrane transporter activity", "d": ["Enables the transfer of D-galactonate, the D-enantiomer of galactonate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2032770", "l": "Translocation of YAP1 to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37138", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate <=> 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64390", "l": "4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate => 4 A + sn-3-O-phytanylglycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033964", "l": "glycosphingolipid deacylase activity", "d": ["Catalysis of the hydrolysis of gangliosides and neutral glycosphingolipids, releasing fatty acids to form the lyso-derivatives."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090704", "l": "nicotinate-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: nicotinate + UDP-D-glucose = O-D-glucosylnicotinate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72106", "l": "Na(+)(out) + O-propanoyl-(R)-carnitine(out) <=> Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44509", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72417", "l": "Li(+)(out) + Na(+)(in) => Li(+)(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210921", "l": "pagA binds ANTXR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73068", "l": "an N(4)-(oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O => an oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62130", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + dGDP => a 2'-deoxyribonucleoside 5'-phosphate + dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59159", "l": "ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] <=> AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.15", "l": "\"thimet oligopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57377", "l": "(S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17792", "l": "(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine <=> (S)-reticuline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209944", "l": "25(OH)D binds GC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50017", "l": "H2O + octanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34407", "l": "3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate", "d": []}, {"i": "EC:2.7.7.84", "l": "\"2'-5' oligoadenylate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.47", "l": "\"dihydromethanopterin reductase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68171", "l": "N-(8'-oxogeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850997", "l": "TRIM27 binds PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879221", "l": "PSTPIP1 binds Pyrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62533", "l": "digitoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) => dihydrodigitoxin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3785711", "l": "Telomere shortening during replicative exhaustion (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25877", "l": "L-aspartate + O2 => H2O2 + iminosuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.24", "l": "\"gelatinase A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878654", "l": "ACP6 hydrolyses MYS-LPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6795667", "l": "MDM2 translocates to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54201", "l": "N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793485", "l": "PRKN polyubiquitinates RIPK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29279", "l": "H(+) + menaquinol-8 + trimethylamine N-oxide = H2O + menaquinone-8 + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17966", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) => (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45567", "l": "2-epi-5-epi-valiolone <=> 5-epi-valiolone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030367", "l": "interleukin-17 receptor binding", "d": ["Binding to an interleukin-17 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951977", "l": "Acetylated RUNX3 binds to BRD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57002", "l": "CoA + H(+) + N(beta)-acetylstreptothricin F => acetyl-CoA + streptothricin F", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0070119", "l": "ciliary neurotrophic factor binding", "d": ["Binding to the cytokine ciliary neurotrophic factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47501", "l": "cholate + NADP(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14291", "l": "AMP + diphosphate + omega-dicarboxyl-CoA => a dicarboxylate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55096", "l": "(3S)-3-hydroxypentanoyl-CoA + H2O = (3S)-3-hydroxypentanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19958", "l": "2 5'-dehydroinosine + O2 => 2 9-riburonosylhypoxanthine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52121", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102887", "l": "beta-sesquiphellandrene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> beta-sesquiphellandrene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29306", "l": "2 H(+)(in) + succinate(in) <=> 2 H(+)(out) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75079", "l": "Formation of AT-AC C complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33425", "l": "diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein] => N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37358", "l": "H2O + uridine 2'-phosphate <=> phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5653957", "l": "Rag dimer formation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213200", "l": "Release of endostatin-like peptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73933", "l": "FAD + griseophenone B + H(+) + 2 H2O => chloride + FADH2 + griseophenone C + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63852", "l": "dodecanoate + O2 = (2R)-2-hydroperoxydodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084912", "l": "Arresten binds integrin alpha1beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70711", "l": "D-alanine(in) = D-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42857", "l": "1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O => 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034523", "l": "3-formylsalicylate oxidase activity", "d": ["Catalysis of the reaction: 3-formylsalicylic acid + O2 + H2O = 2-hydroxyisophthalic acid + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029471", "l": "Hydrolysis of PC to PA by PLD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55150", "l": "a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH => a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047643", "l": "alginate synthase activity", "d": ["Catalysis of the reaction: GDP-D-mannuronate + alginate(n) = GDP + alginate(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781905", "l": "ZRANB1 binds APC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29220", "l": "a menaquinone + sn-glycerol 3-phosphate => a menaquinol + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41114", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58606", "l": "FADH2-C4alpha-hydroperoxide + NAD(+) => FAD + 2 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63149", "l": "H2O + N-(9Z-octadecenoyl)-taurine => (9Z)-octadecenoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036218", "l": "dTTP diphosphatase activity", "d": ["Catalysis of the reaction: dTTP + H2O = dTMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45990", "l": "3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O => 3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26442", "l": "a ubiquinone + ethanol = a ubiquinol + acetaldehyde", "d": []}, {"i": "EC:1.1.5.5", "l": "\"alcohol dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58053", "l": "(2-aminoethyl)phosphonate + acetyl-CoA => (2-acetamidoethyl)phosphonate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16709", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan", "d": []}, {"i": "EC:1.14.16.4", "l": "\"tryptophan 5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67963", "l": "4-amino-L-phenylalanine + S-adenosyl-L-methionine <=> 4-methylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60007", "l": "(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O <=> (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180001", "l": "cyclic-di-AMP binding", "d": ["Binding to a cyclic di-AMP nucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111956", "l": "Calmodulin activates Cam-PDE 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043794", "l": "formate dehydrogenase (coenzyme F420) activity", "d": ["Catalysis of the reaction: formate + coenzyme F420 = CO2 + reduced coenzyme F420."]}, {"i": "EC:1.2.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174209", "l": "Phosphorylated Emi1 binds the beta-TrCP in the SCF complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56034", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043992", "l": "histone H3K9 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189069", "l": "sucrose + H2O => glucose + fructose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16159", "l": "2 Fe(II)-[leghemoglobin] + H(+) + NADP(+) => 2 Fe(III)-[leghemoglobin] + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390649", "l": "CHRM1,3,5 bind acetylcholine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11116", "l": "acetyl-CoA + an alkane-alpha,omega-diamine = an N-acetylalkane-alpha,omega-diamine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-166220", "l": "FA anion diffuses laterally to UCP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665416", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61981", "l": "H(+) + NADPH + ubiquinone-10 => NADP(+) + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669013", "l": "EDA-3 binds EDA2R (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30033", "l": "cis,cis-muconate + H(+) => (S)-muconolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61953", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671862", "l": "JAK2 Phosphorylates IRS in Response to Leptin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19326", "l": "H(+) + NADH + O2 + quinolin-4-ol => H2O + NAD(+) + quinoline-3,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789077", "l": "Hydrogen peroxide enters the bacterium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68156", "l": "(2E)-geranyl diphosphate + L-glutamate = diphosphate + N-geranyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102532", "l": "genkwanin 6-hydroxylase activity", "d": ["Catalysis of the reaction: genkwanin + O2 + NADPH + H+ <=> scutellarein 7-methyl ether + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71324", "l": "chloride(out) + L-asparagine(out) + 2 Na(+)(out) => chloride(in) + L-asparagine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47082", "l": "17beta-hydroxy-5beta-estran-3-one + NADP(+) => 17beta-hydroxyestr-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14060", "l": "a 1,2-diacyl-sn-glycerol + a glycerophospholipid <=> a monoacylglycerophospholipid + a triacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198508", "l": "MDH1 oxidizes MAL to OA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25926", "l": "8-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-8-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102956", "l": "UDP-glucose:sinapaldehyde 4-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + sinapoyl aldehyde = H+ + sinapaldehyde glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21066", "l": "[protein]-dithiol + glutathione disulfide => [protein]-disulfide + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019973", "l": "interleukin-13 binding", "d": ["Binding to interleukin-13."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852716", "l": "Thrombin, ELANE cleave C5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373717", "l": "DCC interacts with DIP13alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733705", "l": "Expression of GATA4 in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30184", "l": "L-galactonate + NAD(+) => H(+) + keto-D-tagaturonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446077", "l": "BP230 interacts with keretin K5/K14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64362", "l": "(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O => (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55111", "l": "3-oxononanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxynonanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.66", "l": "\"XTP/dITP diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15059", "l": "(9Z)-octadecenoate + H(+) + holo-[ACP] => (9Z)-octadecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332390", "l": "Translocation and activation of PKC alpha in response to WNT signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0016634", "l": "oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen."]}, {"i": "EC:1.3.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31922", "l": "indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16790", "l": "a (2S)-2-hydroxycarboxylate + O2 => a 2-oxocarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10861", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 => 2-(acetamidomethylene)succinate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035049", "l": "juvenile hormone acid methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to juvenile hormone acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661425", "l": "BIL:ALB dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448963", "l": "Interaction of MyoD:E protein with MEF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72887", "l": "O2 + polyporic acid + reduced [NADPH--hemoprotein reductase] = ascocorynin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210426", "l": "Glutamate synaptic vesicle docking and priming (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36185", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+) => a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41039", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614614", "l": "Cysteine is degraded to serine and H2S (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67325", "l": "acetyl-CoA + ATP + 11 H(+) + L-serine + 7 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine => (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31381", "l": "1H-pyrrole + hydrogencarbonate => H2O + pyrrole-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205286", "l": "GRB2:SOS interacts with p-KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72731", "l": "UDP-alpha-D-glucose(in) + UMP(out) = UDP-alpha-D-glucose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102205", "l": "cholesterol alpha-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cholesterol = UDP + cholesteryl beta-D-glucoside + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34250", "l": "1-deoxymethyl-sphinganine + NADP(+) <=> 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52550", "l": "2-dehydro-L-erythronate + H(+) + NADH => L-threonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807872", "l": "Active ARF recruits coatomer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25983", "l": "(5S)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59507", "l": "cholesterol + glycyl-L-cysteinyl-[protein] + H(+) <=> [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36257", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046702", "l": "galactoside 6-L-fucosyltransferase activity", "d": ["Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to a galactoside acceptor molecule, usually an N-glycan, to form an alpha(1,6)-fucosylated galactoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49717", "l": "3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 => 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60998", "l": "4-methyl-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-leucine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939201", "l": "ESR dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72754", "l": "H2O + ochratoxin A <=> L-phenylalanine + ochratoxin alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009012", "l": "aminoglycoside 3''-adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + streptomycin = 3''-adenylylstreptomycin + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44616", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O = 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63154", "l": "a fatty acid + taurine => an N-fatty acyl-taurine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019144", "l": "ADP-sugar diphosphatase activity", "d": ["Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64983", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13450", "l": "2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730862", "l": "Autophosphorylation of LYN kinase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74619", "l": "CMP(in) + UMP(out) = CMP(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75829", "l": "(5S,18)-dihydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => (5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687088", "l": "PKA phosphorylates MAPKAPK5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031386", "l": "protein tag activity", "d": ["A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166038", "l": "GPI-bound CD14 binds LPS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194025", "l": "11-deoxycortisol translocates to the mitochondrion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090565", "l": "protein-phosphocysteine-mannitol phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannitol(out) = protein cysteine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130731", "l": "Formation of COPII vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696547", "l": "STAMBPL1 is a deubiquitinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10943", "l": "(2E)-geranyl diphosphate <=> (4R)-limonene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70513", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.136", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.22", "l": "\"endothiapepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22427", "l": "an S-alkyl-L-cysteine + H2O <=> an alkyl thiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209289", "l": "TAB2 binds to ubiquitinated IAP2:BEN:UEV1A E3 ligase complex and activates TAK1 kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44399", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57814", "l": "3-chlorocatechol + NAD(+) + nitrite => 1-chloro-2-nitrobenzene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63568", "l": "beta-casomorphin-7 + H2O = beta-casomorphin-6 + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624120", "l": "CEBPA binds CDK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34206", "l": "2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 <=> aureusidin 6-O-beta-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665767", "l": "Activated FMNL3 binds G-actin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69142", "l": "Recruitment of Dna2 endonuclease (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47151", "l": "a ubiquinone + caffeine + H2O <=> 1,3,7-trimethylurate + a ubiquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12704", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868236", "l": "BAR domain proteins recruit dynamin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879594", "l": "SLCO4C1 mediates the transport of digoxin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014293", "l": "RAC2 GDIs block activation of RAC2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9696274", "l": "RND1 binds GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64472", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine = (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.373", "l": "\"2-hydroxy-4-(methylsulfanyl)butanoate S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45055", "l": "(2E)-butenoyl-CoA + (R)-carnitine <=> CoA + O-(2E)-butenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928639", "l": "p-EFNB binds GRB4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32636", "l": "linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209156", "l": "MYD88 binds to TUB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683635", "l": "E pentamer is transported to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050011", "l": "itaconyl-CoA hydratase activity", "d": ["Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.7", "l": "\"ribonuclease P4\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693347", "l": "HTR1A binds 5HT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29783", "l": "ATP + H2O + L-cysteine(in) = ADP + H(+) + L-cysteine(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56673", "l": "dihydro-4-coumaroyl-CoA + NADP(+) => (E)-4-coumaroyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102442", "l": "syringetin 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: syringetin(1-) + S-adenosyl-L-methionine <=> 3,3',5'-trimethylmyricetin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388809", "l": "CTLA-4 binds B7-1/B7-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37894", "l": "aclacinomycin T + H2O <=> 15-demethylaclacinomycin T + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62039", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48413", "l": "globoside IV3GalNAc-Gb4Cer + H2O => globoside Gb4Cer + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250986", "l": "botG HC:LC binds SYT1 and GT1b on the target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354077", "l": "Integrin alphaIIb beta3 activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72715", "l": "(R)-dihydrolipoate + ATP + H(+) = (R)-N(6)-dihydrolipoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.130", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21708", "l": "H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine", "d": []}, {"i": "EC:3.13.2.1", "l": "\"adenosylhomocysteinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76038", "l": "(S)-cis-N-methylstylopine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + protopine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018766", "l": "RHOU binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50475", "l": "anthraniloyl-CoA + H(+) + malonyl-CoA <=> (2-aminobenzoyl)acetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34638", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 <=> H2O + NADP(+) + pentalenolactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24921", "l": "2-aminobut-2-enoate + H2O => L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47488", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685319", "l": "CX3 complex formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67936", "l": "a 2-hydroxy carboxylate + O2 = a 2-oxocarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052822", "l": "DNA-3-methylguanine glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49601", "l": "ATP + CoA + octanedioate => AMP + diphosphate + octanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30368", "l": "adenosylcob(III)alamin 5'-phosphate + H2O => adenosylcob(III)alamin + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16611", "l": "5-phospho-alpha-D-ribose 1-diphosphate + adenine => AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74336", "l": "O-2-methylbutanoyl-(R)-carnitine(in) => O-2-methylbutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868071", "l": "Clathrin recruits PIK3C2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016643", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein."]}, {"i": "EC:1.4.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11882", "l": "6-hydroxypseudooxynicotine + H2O2 => (S)-6-hydroxynicotine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31280", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate => (2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25391", "l": "(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) = cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.77", "l": "\"3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33063", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin] = NADH + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": []}, {"i": "EC:1.18.1.5", "l": "\"putidaredoxin--NAD(+) reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928654", "l": "Clathrin internalises EPH:EFN complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75856", "l": "9-cis-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] => 9-cis-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5252001", "l": "ATP1B4 binds SNW1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42620", "l": "(Z)-2-methylureidoacrylate + H(+) + H2O = (Z)-2-methylaminoacrylate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250280", "l": "ROS oxidize thioredoxin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044716", "l": "8-oxo-GDP phosphatase activity", "d": ["Catalysis of the reaction 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605313", "l": "Defective MUTYH mutants do not cleave adenine mispaired with 8-oxoguanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9761027", "l": "ZEB2 binds SP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036970", "l": "NTRK3 activates RAS through SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30264", "l": "H2O2 + 2 L-ascorbate => 2 H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726509", "l": "NR3C2 binds fludrocortisone (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52147", "l": "3-phosphonopyruvate + acetyl-CoA + H2O <=> (R)-2-(phosphonomethyl)malate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46467", "l": "(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396399", "l": "Fibrillins bind BMPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863463", "l": "STON2 binds SYT proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707594", "l": "Hemes bind LY96 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35119", "l": "(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O = bisdemethoxycurcumin + CO2 + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706330", "l": "Active FLT3 binds to SOCS6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75413", "l": "H(+) + lactenocin + S-adenosyl-L-homocysteine => demethyllactenocin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12721", "l": "putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine", "d": []}, {"i": "EC:2.5.1.16", "l": "\"spermidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54596", "l": "2-oxoglutarate + hexadecanoyl-CoA + O2 = 2-hydroxyhexadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15600", "l": "a Fe(III)-siderophore(out) + ATP + H2O <=> a Fe(III)-siderophore(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33361", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34989", "l": "(S)-lactate(out) => (S)-lactate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39157", "l": "(2E)-octadecenoyl-CoA + H2O => (3R)-hydroxyoctadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036289", "l": "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855375", "l": "PTPN22 dissociates from CSK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13487", "l": "3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate => 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809565", "l": "I(1,3)P2 is dephosphorylated into I1P by MTMR7:MTMR9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0035252", "l": "UDP-xylosyltransferase activity", "d": ["Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67660", "l": "an (11Z)-eicosenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (8Z,11Z)-eicosadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48287", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose <=> globoside NOR1 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.28", "l": "\"glucosyl-DNA beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.4", "l": "\"type II site-specific deoxyribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611839", "l": "β3-agonists bind ADRB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375302", "l": "Kinetochore capture of astral microtubules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093342", "l": "SDC2 multimerises (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64105", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein] => 1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.93", "l": "\"ATP-dependent NAD(P)H-hydrate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63534", "l": "angiotensin-(1-9) + L-leucine => angiotensin I + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047804", "l": "cysteine-S-conjugate beta-lyase activity", "d": ["Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014293", "l": "RAC2 GDIs block activation of RAC2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.282738951573606", "identifiers": [{"i": "GO:0019899", "l": "enzyme binding", "d": ["Binding to an enzyme, a protein with catalytic activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382055", "l": "Grb7 binds to the active PDGF receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58922", "l": "(+)-medicarpin + H2O => (3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806613", "l": "Keratin tetramers bind to form unit length filaments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032136", "l": "adenine/cytosine mispair binding", "d": ["Binding to a double-stranded DNA region containing an A/C mispair."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0008456", "l": "alpha-N-acetylgalactosaminidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57923", "l": "4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) <=> H(+) + L-asparaginyl-tRNA(Asn) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.6.-", "l": "\"With an nitrogenous group as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46228", "l": "apo-[peptidyl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.28", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41789", "l": "acetyl-CoA + holo-[ACP] => acetyl-[ACP] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20700", "l": "ATP + lipid A disaccharide (E. coli) = ADP + H(+) + lipid IVA (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36029", "l": "H(+) + NADH + propanoyl-CoA => CoA + NAD(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64849", "l": "(3Z)-hex-3-en-1-ol + benzoyl-CoA => (3Z)-hex-3-en-1-yl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0016742", "l": "hydroxymethyl-, formyl- and related transferase activity", "d": ["Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45232", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59676", "l": "D-maltotetraose + O2 = D-maltotetraono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12255", "l": "4-O-(beta-D-glucosyl)-trans-coniferol + H2O <=> (E)-coniferol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53428", "l": "a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52218", "l": "[(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose => [(1''->2')-ADP-alpha-D-ribose](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59344", "l": "D-maltose + O2 = D-maltobiono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16883", "l": "2 H(+) + sulfite + thiocyanate => hydrogen cyanide + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51908", "l": "dATP + H2O = dADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25431", "l": "ATP + N-acetyl-D-hexosamine <=> ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25836", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O = 5-deoxy-D-glucuronate + H(+)", "d": []}, {"i": "EC:3.7.1.22", "l": "\"3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36430", "l": "2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36412", "l": "7-dehydrocholesterol + hnu => calciol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46729", "l": "(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 => (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10753", "l": "[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate => [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358789", "l": "Self-ubiquitination of RNF41 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874979", "l": "ACBD3 binds GOLGB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49105", "l": "Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine => 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635843", "l": "GLI translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218804", "l": "p38 MAPK activation by VEGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.50", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44770", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2 => 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419861", "l": "Melanospin is stimulated by light (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29682", "l": "formate(in) <=> formate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58226", "l": "5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide => L-glutamyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140080", "l": "class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity", "d": ["Catalysis of the cleavage of an AP site 3' and 5' of the baseless site, generating a 3'-phosphate and a 5'-OH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5336182", "l": "GPR37 binds prosaptide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033874", "l": "scymnol sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73797", "l": "FAICAR => IMP + H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13872", "l": "NAD(+) + prephenate <=> 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14828", "l": "(1R,5S)-carveol + NAD(+) <=> (S)-carvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14273", "l": "A + H2O + spermidine = 4-aminobutanal + AH2 + propane-1,3-diamine", "d": []}, {"i": "EC:1.5.99.6", "l": "\"spermidine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61194", "l": "CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => (E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46442", "l": "A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28539", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49923", "l": "(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-octanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60947", "l": "quercetin + S-adenosyl-L-methionine <=> H(+) + isorhamnetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3240957", "l": "Formation of PRC2-EZH2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32508", "l": "4-isopropenyl-7-methyloxepan-2-one + H2O => 6-hydroxy-3-isopropenylheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14935", "l": "N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate => H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295622", "l": "SPRY2 binds CBL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60044", "l": "beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43254", "l": "1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate => 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49089", "l": "FAD + H(+) + H2O + squalene => FADH2 + hydroxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19923", "l": "D-ribulose 5-phosphate + H(+) + NADPH => D-ribitol 5-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41792", "l": "holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]", "d": []}, {"i": "EC:2.3.1.39", "l": "\"[acyl-carrier-protein] S-malonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983142", "l": "Formation of peptide loading complex (PLC) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166387", "l": "The FA anion diffuses away laterally from UCP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444202", "l": "Receptor FFAR1 binds free fatty acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000341", "l": "RNA trimethylguanosine cap binding", "d": ["Binding to the trimethylguanosine (m(3)(2,2,7)-GTP) group located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11817", "l": "alpha-D-glucose 6-phosphate => beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38216", "l": "D-glucose 6-phosphate + NAD(+) => 6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57362", "l": "(6R)-NADHX => H2O + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928576", "l": "RHOA:GTP binds ROCK, activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10644", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H2O = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)", "d": []}, {"i": "EC:3.1.1.57", "l": "\"2-pyrone-4,6-dicarboxylate lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41996", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose = globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8934446", "l": "Activated PKC phosphorylates SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0047708", "l": "biotinidase activity", "d": ["Catalysis of the reaction: biotin amide + H2O = biotin + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59234", "l": "diphosphate + hydropyrenol => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033809", "l": "anthocyanin 6''-O-malonyltransferase activity", "d": ["Catalysis of the reaction: malonyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = CoA + an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46613", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol => (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373087", "l": "Receptor CCR6 binds CCL20 ligand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70893", "l": "L-asparagine(in) + L-glutamine(out) + Na(+)(in) => L-asparagine(out) + L-glutamine(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32494", "l": "alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58927", "l": "(3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol <=> (-)-maackiain + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54632", "l": "2-oxoglutarate + O2 + tetradecanoyl-CoA = 2-hydroxytetradecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029591", "l": "Expression of ABCG8 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11373", "l": "ATP + L-aspartate + NH4(+) => AMP + diphosphate + H(+) + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663002", "l": "MT3 binds copper (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37850", "l": "13-dihydrodaunorubicin + H(+) + NADPH + O2 <=> daunorubicin + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181354", "l": "CERBERUS binds NODAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27400", "l": "4'-demethylrebeccamycin + H2O <=> beta-D-glucose + dichloroarcyriaflavin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26476", "l": "alpha-D-galactose 1-phosphate + L-rhamnopyranose => beta-D-galactosyl-(1->4)-L-rhamnose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168046", "l": "Collagen type XII degradation by MMP12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683964", "l": "ATM phosphorylates EYA1-4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49331", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene <=> 2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71545", "l": "5-phosphomethyl-dUMP in DNA + ADP + H(+) => 5-hydroxymethyl-dUMP in DNA + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19581", "l": "N(6)-dimethylallyladenine + S-adenosyl-L-methionine = discadenine + H(+) + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.24", "l": "\"discadenine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174731", "l": "Degradation of newly synthesized ApoB-48 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047636", "l": "alanopine dehydrogenase activity", "d": ["Catalysis of the reaction: 2,2'-iminodipropanoate + H2O + NAD+ = L-alanine + H+ + NADH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22938", "l": "acetate + D-glucosamine 6-phosphate => H2O + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43042", "l": "CoA + H(+) + N-hexadecanoylhexadecasphinganine => hexadecanoyl-CoA + hexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63368", "l": "ATP + H2O + spermine(out) = ADP + H(+) + phosphate + spermine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43778", "l": "an N-(acyl)-sphingosylphosphocholine(out) => an N-(acyl)-sphingosylphosphocholine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60658", "l": "1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21458", "l": "(S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22567", "l": "a 2,3-saturated acyl-[ACP] + NADP(+) <=> a (2E)-enoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714483", "l": "RAC2 translocates to the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483087", "l": "PI is exchanged with PC by PITPNB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52549", "l": "L-threonate + NAD(+) => 2-dehydro-L-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63985", "l": "5-hydroxyuridine + ATP => 5-hydroxyuridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18139", "l": "5alpha-pregnane-3,20-dione + H(+) + NADPH => 3beta-hydroxy-5alpha-pregnane-20-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63990", "l": "2-thiocytidine 5'-phosphate + ADP + H(+) => 2-thiocytidine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.108", "l": "\"UDP-3-O-acyl-N-acetylglucosamine deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70896", "l": "N-terminal L-cysteinyl-[protein] + O2 => H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52269", "l": "3-(aminomethyl)indole + S-adenosyl-L-methionine => (1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1006143", "l": "CD46 binds C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37011", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621606", "l": "CD209 binds ManLAM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63675", "l": "(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH <=> H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75877", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) => (6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876948", "l": "SRC phosphorylates InlA-bound CDH1 and CTNNB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004321", "l": "fatty-acyl-CoA synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70080", "l": "2-oxoglutarate + clavatol + O2 => CO2 + hydroxyclavatol + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354124", "l": "Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551555", "l": "RYK binds WNT5A and VANGL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604712", "l": "Initial activation of proMMP7 by trypsin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9008822", "l": "PPM1D dephosphorylates RUNX2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014454", "l": "RHOG translocates to the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814555", "l": "Integrator complex processes the 3' end of snRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54058", "l": "(2E,6E)-hedycaryol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50897", "l": "8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O => (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009485", "l": "IL34:CSF1 binds CSF1R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70692", "l": "ornithine => putrescine + CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64617", "l": "(E)-coniferol + acetyl-CoA => (E)-coniferyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.3", "l": "\"microbial collagenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5591086", "l": "SERPINA5 binds activated protein C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57691", "l": "apo-[corrinoid adenosyltransferase] + cob(II)inamide <=> cob(II)inamide-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62213", "l": "3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase] => gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034826", "l": "1,2-dihydroxy-1,2,5,6,7,8-hexyhadronaphthalene dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+ = 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9681294", "l": "IL6R binds IL6R inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51979", "l": "an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55901", "l": "chloride + FADH2 + L-tryptophan + O2 => 6-chloro-L-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17107", "l": "malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine => malonyl-[ACP] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210285", "l": "Trans-homophilic interaction of PECAM-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45987", "l": "3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32956", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10590", "l": "4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase] => 4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18682", "l": "phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine => phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17075", "l": "CoA + cortisol 21-acetate => acetyl-CoA + cortisol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21957", "l": "UDP-alpha-D-glucose + vitexin => H(+) + UDP + vitexin 2''-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878212", "l": "JAG1 gene expression is inhibited by RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70348", "l": "bromide + L-tyrosine + NADP(+) => 3-bromo-L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.45", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66082", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate => 2-oxopentanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46146", "l": "(24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061543", "l": "3-demethylubiquinol-6 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-6 = S-adenosyl-L-homocysteine + ubiquinol-6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46101", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => cortisol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55760", "l": "a fatty acyl-[ACP] + a lyso-ornithine lipid = an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.270", "l": "\"lyso-ornithine lipid O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15046", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) => (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051870", "l": "methotrexate binding", "d": ["Binding to methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74712", "l": "Dissociation of IRS-P from insulin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75613", "l": "plasmodiophorol C => H2O + plasmodiophorol A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51458", "l": "(9Z)-octadecenoate + L-isoleucine => H2O + N-(9Z-octadecenoyl)-L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67501", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2106615", "l": "Removal of siRNA passenger strand (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202500", "l": "Activation of IKK complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211924", "l": "CYP4B1 12-hydroxylates ARA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37467", "l": "1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53447", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174438", "l": "Formation of the Flap Intermediate on the C-strand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66265", "l": "ATP + H(+) + nonanoate => diphosphate + nonanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56227", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30385", "l": "(-)-7-epi-alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070540", "l": "stearic acid binding", "d": ["Binding to stearic acid, the 18-carbon saturated fatty acid octadecanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54849", "l": "H(+) + hexan-3-one + NADPH + O2 => H2O + NADP(+) + propyl propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015381", "l": "high-affinity sulfate transmembrane transporter activity", "d": ["Enables the secondary active high affinity transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75507", "l": "n H(+)(out) + taurocholate(out) = n H(+)(in) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68960", "l": "DNA polymerase epsilon binds at the origin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928657", "l": "MMP2,9 cleave EPHB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67086", "l": "ADP + H(+) + hexacosanoate(out) + phosphate => ATP + H2O + hexacosanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727819", "l": "TAK1 phosphorylates MKK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038046", "l": "G protein-coupled enkephalin receptor activity", "d": ["Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875183", "l": "CBL monoubiquitinates activated MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0016856", "l": "racemase and epimerase activity, acting on hydroxy acids and derivatives", "d": ["Catalysis of a reaction that alters the configuration of one or more chiral centers in a hydroxy acid molecule."]}, {"i": "EC:5.1.2.-", "l": "\"Acting on hydroxy acids and derivatives\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25257", "l": "N-acetyl-D-glucosamine 6-phosphate = N-acetyl-D-mannosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69191", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate <=> ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27857", "l": "(2E)-geranyl diphosphate + 4-hydroxybenzoate <=> 3-geranyl-4-hydroxybenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59388", "l": "a fatty acid ester + H2O = a fatty acid + an aliphatic alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23689", "l": "adenine + H(+) + H2O => hypoxanthine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67761", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28888", "l": "H(+)(in) + L-serine(in) => H(+)(out) + L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39047", "l": "26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662606", "l": "MT3 binds zinc (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51506", "l": "a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP => a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39214", "l": "(3R)-hydroxyhexacosanoyl-CoA <=> (2E)-hexacosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046876", "l": "3,4-didehydroretinal binding", "d": ["Binding to 3,4-didehydroretinal, a form of retinal that plays a role in the visual process in freshwater fish and some amphibians analogous to that of all-trans retinal in other vertebrates. 3,4-didehydro-11-cis-retinal combines with an opsin to form cyanopsin (cone) or porphyropsin (rod)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50839", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 <=> 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103011", "l": "mannosylfructose-phosphate synthase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose + beta-D-fructofuranose 6-phosphate <=> mannosylfructose-phosphate + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446364", "l": "Migfilin interacts with VASP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170156", "l": "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851352", "l": "CCR8 binds CCL1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65521", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51059", "l": "A + androst-4-ene-3,17-dione <=> AH2 + androsta-1,4-diene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68611", "l": "Formation of ORC(1-5) complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-166387", "l": "The FA anion diffuses away laterally from UCP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071209", "l": "U7 snRNA binding", "d": ["Binding to a U7 small nuclear RNA (U7 snRNA)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140757", "l": "cysteine-type deNEDDylase activity", "d": ["An thiol-dependent isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36837", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982617", "l": "CYGB:O2 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72800", "l": "L-arginine(out) + L-homoarginine(in) => L-arginine(in) + L-homoarginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63087", "l": "chloride + FADH2 + ilicicolin B + O2 <=> FAD + H(+) + 2 H2O + ilicicolin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114544", "l": "p115-RhoGEF activation of RHOA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18702", "l": "arsenite + H2O + 2 oxidized [azurin] => arsenate + 3 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647994", "l": "RAS proteins are depalmitoylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36468", "l": "H2O + L-alanylglycine => glycine + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39358", "l": "(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451481", "l": "TLR7 binds to recognized ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3159227", "l": "HIV Virion Budding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43988", "l": "(2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2 = (2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59637", "l": "D-xylotriose + O2 => D-xylotriono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1564169", "l": "Collagen type VIII degradation by MMP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50471", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH <=> 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5333678", "l": "CPNEs bind PL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25504", "l": "(2E)-geranyl diphosphate = beta-phellandrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950716", "l": "IL27RA binds JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042356", "l": "GDP-4-dehydro-D-rhamnose reductase activity", "d": ["Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12068", "l": "apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]", "d": []}, {"i": "EC:2.7.8.7", "l": "\"holo-[acyl-carrier-protein] synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58782", "l": "a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine => a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21080", "l": "ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine", "d": []}, {"i": "EC:2.5.1.6", "l": "\"methionine adenosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624956", "l": "PDE6D binds INPP5E (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11974", "l": "12 H(+) + 4 iron(III) oxide-hydroxide => 4 Fe(2+) + 6 H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2995376", "l": "BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69754", "l": "Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692408", "l": "NPR2 binds NPPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964759", "l": "Alternative endo-mannosidase I route (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654409", "l": "Activated FGFR3 binds FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334052", "l": "TFC7L2 mutants don't bind CTBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51435", "l": "(S)-1-aminoethylphosphonate + acetyl-CoA <=> [(1S)-1-acetamidoethyl]phosphonate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44972", "l": "(R)-carnitine + hexanoyl-CoA = CoA + O-hexanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17493", "l": "A + glycerol = AH2 + dihydroxyacetone", "d": []}, {"i": "EC:1.1.99.22", "l": "\"glycerol dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22950", "l": "D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => D-tagatofuranose 1,6-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0061602", "l": "molybdenum cofactor cytidylyltransferase activity", "d": ["Catalysis of the reaction CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66648", "l": "(2E,6E)-farnesyl diphosphate = african-3-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004310", "l": "farnesyl-diphosphate farnesyltransferase activity", "d": ["Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29560", "l": "H2O + UDP-alpha-D-glucuronate => 1-phospho-alpha-D-glucuronate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67656", "l": "2 Fe(III)-[cytochrome c] + NADPH = 2 Fe(II)-[cytochrome c] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36414", "l": "7-dehydrocholesterol + hnu <=> calciol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64923", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50872", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 = (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9710959", "l": "p-STAT1 dimer binds KPNA1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42211", "l": "a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2 <=> a (Z)-omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018628", "l": "terephthalate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690886", "l": "ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419490", "l": "Binding of ATP to P2X receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55515", "l": "cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.863640214551324", "identifiers": [{"i": "GO:0016894", "l": "endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters."]}, {"i": "EC:3.1.31.1", "l": "\"micrococcal nuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42752", "l": "pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.177", "l": "\"23S rRNA (pseudouridine(1915)-N(3))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49762", "l": "ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O => EDTA + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51841", "l": "2 Na(+)(out) + tauroallocholate(out) => 2 Na(+)(in) + tauroallocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928620", "l": "PAK1 autophosphorylates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75095", "l": "2 chloride(in) + oxalate(out) = 2 chloride(out) + oxalate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034956", "l": "diphenyl ether 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: diphenyl ether + NADH + O2 + H+ = phenol + catechol + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30355", "l": "a quinol + methane + O2 = a quinone + H2O + methanol", "d": []}, {"i": "EC:1.14.18.3", "l": "\"methane monooxygenase (particulate)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-179417", "l": "Multiubiquitination of Nek2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38650", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35093", "l": "2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine => anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66509", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46839", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12585", "l": "16alpha-hydroxyprogesterone => 16,17-didehydroprogesterone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046703", "l": "natural killer cell lectin-like receptor binding", "d": ["Binding to a lectin-like natural killer cell receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102716", "l": "gibberellin A28,oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A28 + 2-oxoglutarate + O2 <=> (2betaOH)-gibberellin28 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043728", "l": "2-keto-4-methylthiobutyrate aminotransferase activity", "d": ["Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11549", "l": "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O => 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39966", "l": "2-hexadecanoylglycerol + H2O <=> glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37624", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018722", "l": "1-phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: 1-phenanthrol + X-SO3(-) = HX + 1-phenanthrylsulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50708", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53917", "l": "an acyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-acyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19018", "l": "(6S)-NADHX + ATP => ADP + H(+) + NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69003", "l": "3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine <=> 3-amino-2-hydroxy-4-methoxybenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44639", "l": "2,4-dinitroanisole + H2O <=> 2,4-dinitrophenol + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75339", "l": "chloride(out) + nitrate(in) = chloride(in) + nitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71849", "l": "LDH tetramer reduces PYR to LACT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58707", "l": "rifampicin hemiaminal <=> rifampicin ortho-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74427", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16423", "l": "a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43318", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53325", "l": "2-glyceryl-prostaglandin H2 => 2-glyceryl-prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30926", "l": "(R)-glycerate + ADP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862700", "l": "CMKLR1 binds Resolvin E1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418200", "l": "SRC-1 bound to ARRB2 is not activated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33449", "l": "3-dehydro-4-methylzymosterol + CO2 + NADPH => 4beta-methylzymosterol-4alpha-carboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11547", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine <=> H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71815", "l": "3,3',5'-triiodo-L-thyronine(out) = 3,3',5'-triiodo-L-thyronine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44301", "l": "2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA => 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20083", "l": "hexanoate + methylamine => H2O + N-methylhexanamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57130", "l": "(4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin] => H2O + 2 oxidized [azurin] + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64744", "l": "H2O + S-3-(hexan-1-ol)-L-cysteine = 3-sulfanyl-1-hexanol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38272", "l": "(3S)-citramalyl-CoA => 3-methylfumaryl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34774", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) <=> a 3-oxosteroid + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51251", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68379", "l": "glyoxylate + L-asparagine <=> 2-oxosuccinamate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424476", "l": "Activation of RAC1 by VAV2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9609921", "l": "SGTA binds Tail-anchored protein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450550", "l": "PKCalpha phosphorylates HuR (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804253", "l": "MDM2 ubiquitinates JMY (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46283", "l": "an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31518", "l": "4'-apo-beta-carotenal + H2O + NAD(+) <=> 2 H(+) + NADH + neurosporaxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804379", "l": "PRMT5 binds TTC5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69728", "l": "2-phenylacetate + ATP + H(+) => diphosphate + phenylacetyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25775", "l": "2-oxoglutarate + L-asparagine + O2 <=> (2S,3S)-3-hydroxyasparagine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74911", "l": "a (2E)-enoyl fatty acid + ATP + holo-[ACP] = a (2E)-enoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23259", "l": "adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine <=> adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65397", "l": "8-oxo-dATP + H2O => 8-oxo-dAMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26052", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052602", "l": "4-chloronitrobenzene nitroreductase activity", "d": ["Catalysis of the reaction: 4-chloronitrobenzene + NADPH + H+ = 1-chloro-4-nitrosobenzene + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928640", "l": "PAKs phosphorylate MLC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64246", "l": "an N-(fatty acyl)-glycine + CoA + H(+) => a fatty acyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429157", "l": "ABCC4 accumulation of dense granule contents (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034432", "l": "bis(5'-adenosyl)-pentaphosphatase activity", "d": ["Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047290", "l": "alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity", "d": ["Catalysis of the reaction: alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R + CMP-N-acetyl-beta-neuraminate = alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R + CMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632914", "l": "TP53 binds the GLS2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9689608", "l": "MPP5 binds SARS-CoV-1 E pentamer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49920", "l": "(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-octanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690196", "l": "USP8 deubiquitinates RNF128 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672951", "l": "Inactive RAFs bind YWHAB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17459", "l": "[sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine => [sulfur-carrier protein]-L-cysteine + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33095", "l": "chorismate + inosine + phosphoenolpyruvate = futalosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71673", "l": "glycyl-L-glutamine(in) + H(+)(in) => glycyl-L-glutamine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39594", "l": "(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA <=> (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75018", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate <=> 2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hexadecanoyloxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030345", "l": "structural constituent of tooth enamel", "d": ["The action of a molecule that contributes to the structural integrity of tooth enamel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3132759", "l": "TCN1 binds RCbl (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71070", "l": "L-arginine(in) + L-phenylalanine(out) <=> L-arginine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58198", "l": "acetate + L-lysyl-[histone] => H2O + N(6)-acetyl-L-lysyl-[histone]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66332", "l": "L-aspartate(out) = L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41683", "l": "a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) <=> a 2-all-trans-polyprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034512", "l": "box C/D RNA binding", "d": ["Binding to a box C/D small nucleolar RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1861789", "l": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46831", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430135", "l": "p-SLP-76 binds ADAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989745", "l": "Expression of ACADM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54958", "l": "AMP + diphosphate + OPC-6-CoA => ATP + CoA + OPC-6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73929", "l": "griseophenone C + S-adenosyl-L-homocysteine => griseophenone D + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31559", "l": "L-galactose + NAD(+) = H(+) + L-galactono-1,4-lactone + NADH", "d": []}, {"i": "EC:1.1.1.316", "l": "\"L-galactose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140937", "l": "histone H4K12 deacetylase activity", "d": ["Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 12) + H2O = histone H4 L-lysine (position 12) + acetate. This reaction represents the removal of an acetyl group from lysine at position 12 of the histone H4 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000137", "l": "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174157", "l": "Degradation of multiubiquitinated Cyclin B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32694", "l": "(2E)-geranyl diphosphate <=> (E)-beta-ocimene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654651", "l": "Activated FGFR4 binds FRS3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855160", "l": "I(1,3,4,5,6)P5 transports from the ER lumen to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429732", "l": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1977959", "l": "ERBB4 forms heterodimers with EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391942", "l": "IP receptor can bind prostacyclin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031845", "l": "type 5 neuropeptide Y receptor binding", "d": ["Binding to a type 5 neuropeptide Y receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18413", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.179", "l": "\"lactosylceramide beta-1,3-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14768", "l": "coelenterazine h + O2 <=> CO2 + excited coelenteramide h monoanion + H(+) + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48961", "l": "[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide => [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0032067", "l": "type IV site-specific deoxyribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52126", "l": "(19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75384", "l": "bromide(in) => bromide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229283", "l": "LCNs bind lipids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690023", "l": "NUBPL binds 4Fe-4S (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618392", "l": "miR-26 binds to the 3'UTR of the ARL4C mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035983", "l": "Defective HEXB does not cleave the terminal GalNAc from keratan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170964", "l": "FRS2 binds to active TrkA receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35765", "l": "aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase] => 8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72843", "l": "3'-dephospho-CoA(in) + ADP(out) = 3'-dephospho-CoA(out) + ADP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68778", "l": "diphosphate + germacrene A => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50909", "l": "a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 => A + a 3-demethylubiquinol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.15", "l": "\"succinyl-CoA:(R)-benzylsuccinate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28294", "l": "(2E,6E)-farnesyl diphosphate = (-)-(E)-beta-caryophyllene + diphosphate", "d": []}, {"i": "EC:4.2.3.57", "l": "\"(-)-beta-caryophyllene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29521", "l": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49329", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene => 2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990518", "l": "single-stranded 3'-5' DNA helicase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9676257", "l": "Formation of the SET1A complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102067", "l": "geranylgeranyl diphosphate reductase activity", "d": ["Catalysis of the reaction: (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + 3 NADP <=> 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + 3 NADPH + 3 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61496", "l": "an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75961", "l": "(S)-3-O-demethylscoulerine + CO2 + formaldehyde + succinate => (S)-scoulerine + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40340", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0033857", "l": "diphosphoinositol-pentakisphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41959", "l": "2',3'-cyclophospho-CMP + H2O <=> cytidine 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58686", "l": "FADH2-C4alpha-hydroperoxide + NADP(+) => FAD + 2 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69208", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ATP + L-glutamate = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0033207", "l": "beta-1,4-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming a beta-1,4 linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71516", "l": "hypoxanthine(out) => hypoxanthine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879562", "l": "SLCO2B1 has a narrow substrate specificity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45443", "l": "H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine <=> H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641111", "l": "Parkin transfers Ub to misfolded proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51053", "l": "5alpha-androstan-3,17-dione + A => 5alpha-androst-1-ene-3,17-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770142", "l": "Formation of the Spliceosomal B complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37486", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine <=> 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0016886", "l": "ligase activity, forming phosphoric ester bonds", "d": ["Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}, {"i": "EC:6.5.-.-", "l": "\"Forming phosphoric ester bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442913", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50229", "l": "FADH2 + O2 + resorcinol => benzene-1,2,4-triol + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30868", "l": "H2O + indole-3-acetaldehyde + NAD(+) => (indol-3-yl)acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44948", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O = 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35124", "l": "H(+)(out) + L-alanyl-D-glutamate(out) => H(+)(in) + L-alanyl-D-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009917", "l": "sterol 5-alpha reductase activity", "d": ["Catalysis of the removal of a C-5 double bond in the B ring of a sterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047395", "l": "glycerophosphoinositol glycerophosphodiesterase activity", "d": ["Catalysis of the reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = sn-glycerol 3-phosphate + myo-inositol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938853", "l": "CDK6 binds RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318563", "l": "Defective MTRR does not convert cob(II)alamin to MeCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71940", "l": "2-oxoglutarate(out) + 3 Na(+)(out) => 2-oxoglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23118", "l": "4-hydroxybenzoyl-CoA + AMP + diphosphate => 4-hydroxybenzoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380239", "l": "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375140", "l": "CDO binds promyogenic cadherins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60749", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone => CoA + pyrethrin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013004", "l": "RHOA binds effectors at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74652", "l": "CTP + N-acetyl-D-glucosamine => CDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003862", "l": "3-isopropylmalate dehydrogenase activity", "d": ["Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.75", "l": "\"furin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24134", "l": "UDP-alpha-D-galactofuranose => UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247839", "l": "Retromer associates with WLS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034856", "l": "2-hydroxyhexa-2,4-dienoate hydratase activity", "d": ["Catalysis of the reaction: (2E,4E)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42027", "l": "3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) <=> 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41545", "l": "8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine => 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062184", "l": "testosterone 16-beta-hydroxylase activity", "d": ["Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."]}, {"i": "RHEA:46304", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693593", "l": "D-loop extension by DNA polymerases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64466", "l": "H(+) + H2O2 + L-topaquinyl-[protein] => L-tyrosyl-[protein] + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433374", "l": "Processing of SCF isoform 1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16081", "l": "(2R)-S-methyl-3-phospho-1-thioglycerate + H2O = (2R)-S-methyl-1-thioglycerate + phosphate", "d": []}, {"i": "EC:3.1.3.14", "l": "\"methylphosphothioglycerate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20624", "l": "ATP + H2O + Zn(2+)(in) <=> ADP + H(+) + phosphate + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42404", "l": "H2O + lactose 6-phosphate = beta-D-glucose + D-galactose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45086", "l": "7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947531", "l": "Molybdenum ion transfer onto molybdopterin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20566", "l": "(2E)-geranyl diphosphate + H2O => (1S,2S,4R)-endo-fenchol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0045181", "l": "glutamate synthase activity, NAD(P)H as acceptor", "d": ["Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16405", "l": "benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) = benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.217", "l": "\"benzyl-2-methyl-hydroxybutyrate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39024", "l": "an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39663", "l": "a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.1.98.4", "l": "\"F420H2:quinone oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870469", "l": "RGGT geranylgeranylates RAB proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16931", "l": "2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine => 2 benzoyl-CoA + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44979", "l": "(R)-carnitine + propanoyl-CoA <=> CoA + O-propanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863674", "l": "CDC25C binds YWHAE (14-3-3-epsilon) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-996755", "l": "ZFPM proteins bind GATA proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8931981", "l": "RUNX1 binds ESR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450550", "l": "PKCalpha phosphorylates HuR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.5", "l": "\"ribonuclease P\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49316", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.21", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0018030", "l": "peptidyl-lysine N6-myristoyltransferase activity", "d": ["Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36913", "l": "3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA => (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24034", "l": "6-O-alpha-D-glucopyranosyl-D-fructose => sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64119", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650858", "l": "Meglitinides bind ABCC8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.241", "l": "\"Kdo2-lipid IVA acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247569", "l": "PADI4 deiminates Histones (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13426", "l": "a pyrimidine ribonucleoside 5'-phosphate + H2O => a pyrimidine nucleobase + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400434", "l": "FFAR1 binds fatty acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213239", "l": "Formation of MHC II alpha beta heterodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41478", "l": "CoA + zymosterol ester => an acyl-CoA + zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75192", "l": "2-dehydro-3-deoxy-L-fuconate + NAD(+) => 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23336", "l": "2 H(+) + H2O2 + 2 iodide = diiodine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33209", "l": "ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate => ATP + H(+) + L-glutamate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013986", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114284", "l": "Release of Cytochrome c from mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70866", "l": "L-glutamine(out) + L-threonine(in) + Na(+)(out) <=> L-glutamine(in) + L-threonine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62714", "l": "H2O + NADP(+) + stemphyloxin I => betaenone C + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1369028", "l": "ABCAs mediate lipid efflux (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58218", "l": "AH2 + serpentine => A + dihydroserpentine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25299", "l": "acetaldehyde + H2O + NADP(+) => acetate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55543", "l": "40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] <=> 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160010", "l": "protein de-2-hydroxyisobutyrylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] = 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]."]}, {"i": "RHEA:69176", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] = 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.6", "l": "\"chymopapain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67980", "l": "beta-zeacarotene = 7,8-dihydro-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23826", "l": "2,3-dihydroxybenzoate + H(+) + NADH => (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868118", "l": "MAPK12 phosphorylates PTPN3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44366", "l": "2-epi-5-epi-valiolone 7-phosphate + ADP + H(+) => 2-epi-5-epi-valiolone + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52047", "l": "mogrol + UDP-alpha-D-glucose <=> H(+) + mogroside IE + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72558", "l": "estrone 3-sulfate(out) + propanoate(in) <=> estrone 3-sulfate(in) + propanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48099", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55799", "l": "H(+) + NADH + O2 + phenol <=> H2O + hydroquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73797", "l": "FAICAR => IMP + H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008904", "l": "hygromycin-B 7''-O-phosphotransferase activity", "d": ["Catalysis of the reaction: ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984606", "l": "Kinesin-5 is a homotetramer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192061", "l": "CYP46A1 24-hydroxylates CHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036061", "l": "Defective GLB1 does not hydrolyse linker chain(2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65629", "l": "sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73562", "l": "dGTP(out) + UTP(in) <=> dGTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29573", "l": "H(+)(out) + L-idonate(out) => H(+)(in) + L-idonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14574", "l": "D-glucarate => 5-dehydro-4-deoxy-D-glucarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64676", "l": "3-(methylsulfanyl)propanoyl-CoA + butan-1-ol = butyl 3-(methylsulfanyl)propanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432054", "l": "Aquaporin-1 passively transports water out of cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950113", "l": "IL12A binds IL12B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75881", "l": "methyl-Co(III)-[quaternary-amine-specific corrinoid protein] + N-methyl-L-proline => Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) + L-proline betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592398", "l": "Activation of proMMP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45271", "l": "4'-hydroxyechinenone + AH2 + O2 <=> 4',4'-dihydroxyechinenone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950456", "l": "IL12B dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20233", "l": "a 7beta-hydroxysteroid + NADP(+) = a 7-oxosteroid + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.201", "l": "\"7beta-hydroxysteroid dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74246", "l": "H2O + L-alanyl-tRNA(Pro) <=> H(+) + L-alanine + tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062058", "l": "transcription factor TFIIH holo complex binding", "d": ["Binding to a transcription factor TFIIH holo complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-982810", "l": "JAK2 phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31795", "l": "(+)-(E)-beta-caryophyllene + H2O = (+)-caryolan-1-ol", "d": []}, {"i": "EC:4.2.1.138", "l": "\"(+)-caryolan-1-ol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28156", "l": "alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+) => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41552", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = diphosphate + ophiobolin F", "d": []}, {"i": "EC:4.2.3.145", "l": "\"ophiobolin F synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41294", "l": "H2O + N-dodecanoylsphing-4-enine <=> dodecanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19987", "l": "H(+) + NADH + S-formylglutathione => NAD(+) + S-(hydroxymethyl)glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30861", "l": "dIDP + H(+) + phosphate => dITP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9726509", "l": "NR3C2 binds fludrocortisone (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247837", "l": "WNT ligands traffic to the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70638", "l": "H2O + N(6)-octanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-octanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15754", "l": "GTP + IMP + L-aspartate => GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038122", "l": "C-C motif chemokine 5 receptor activity", "d": ["Combining with the C-C motif chemokine 5 (CCL5) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003746", "l": "translation elongation factor activity", "d": ["Functions in chain elongation during polypeptide synthesis at the ribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49973", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21064", "l": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide", "d": []}, {"i": "EC:1.8.4.2", "l": "\"protein-disulfide reductase (glutathione)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13503", "l": "ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate => ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72498", "l": "glutarate(in) + prostaglandin E2(out) <=> glutarate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45510", "l": "(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin beta-subunit] => phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67342", "l": "CoA + quercetin 3-O-(6-O-malonyl-beta-D-glucoside) => malonyl-CoA + quercetin 3-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26288", "l": "Co-precorrin-5B + S-adenosyl-L-methionine <=> Co-precorrin-6A + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6804276", "l": "ATM phosphorylates TTC5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71733", "l": "citrate(in) + tartrate(out) => citrate(out) + tartrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71810", "l": "a 2'-deoxyguanosine in DNA + NAD(+) <=> an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53729", "l": "H2O + N-acetyl-D-muramate 6-phosphate => N-acetyl-D-muramate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74890", "l": "2',3'-cGAMP(in) + ATP + H2O <=> 2',3'-cGAMP(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21996", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA = a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA", "d": []}, {"i": "EC:2.3.1.125", "l": "\"1-alkyl-2-acetylglycerol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008097", "l": "5S rRNA binding", "d": ["Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16758", "l": "NADP(+) + trypanothione => H(+) + NADPH + trypanothione disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65881", "l": "1-hydroxy-5alpha-androstan-3,17-dione + A => 5alpha-androstan-1,3,17-trione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10883", "l": "7-methylxanthosine + H2O <=> 7-methylxanthine + D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38721", "l": "(R)-carnitine(in) + ADP + H(+) + phosphate => (R)-carnitine(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16701", "l": "17alpha-estradiol + NAD(+) = estrone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70428", "l": "H2O + phenylacetyl-CoA => 2-phenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56993", "l": "6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => (+)-costunolide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39076", "l": "(2E)-dodecenedioyl-CoA + H2O => (3S)-hydroxydodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.1", "l": "\"succinate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692809", "l": "CDC42 binds effectors at the ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.36", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58427", "l": "(E)-hex-2-en-1-ol + NADP(+) <=> (E)-hex-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12740", "l": "5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine <=> [PrdC protein]-L-selenocysteine/L-cysteine + D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646468", "l": "mTORC1 binds RHEB:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34670", "l": "C30 botryococcene + S-adenosyl-L-methionine <=> 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41265", "l": "15-oxo-prostaglandin A1 + H(+) + NADH => NAD(+) + prostaglandin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685953", "l": "SIRT6 deacetylates RBBP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013147", "l": "RAC1 GDIs block activation of RAC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27930", "l": "(R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.2.36", "l": "\"4-phosphopantoate--beta-alanine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23510", "l": "(7R)-7-aminocephalosporanate + glutarate => (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46377", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701485", "l": "Active ALK binds JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804527", "l": "INTL1 binds bacterial glycans (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61752", "l": "steviolbioside + UDP-alpha-D-glucose = H(+) + rebaudioside B + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357483", "l": "RAC1 binds PAK1-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218815", "l": "p-6Y-VEGFR2 binds NCK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445071", "l": "Reinsertion of L1 into the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676599", "l": "sBAFF trimer binds BAFFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951644", "l": "Release of mature NEDD8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48857", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733292", "l": "AMY1-3 bind pramlintide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005001", "l": "transmembrane receptor protein tyrosine phosphatase activity", "d": ["Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371591", "l": "Trimerization of cytosolic HSF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140517", "l": "protein-RNA adaptor activity", "d": ["The binding activity of a protein that brings together another protein and an RNA, permitting those molecules to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72722", "l": "eIF2 activation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59784", "l": "H2O + NADP(+) + pseudopaline = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34759", "l": "ATP + glycerol 2-phosphate(out) + H2O = ADP + glycerol 2-phosphate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31532", "l": "2-oxoglutarate + L-arginine + O2 => CO2 + N(omega)-hydroxy-L-arginine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51559", "l": "(S)-glaucine + S-adenosyl-L-methionine <=> (S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35804", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O => 7,8-dihydroneopterin 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15994", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 => 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879910", "l": "JAK2 is phosphorylated, activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38173", "l": "2-hydroxyhexadecyl hexadecanoate + CoA => hexadecane-1,2-diol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9704248", "l": "CHRM4 binds CHRM4 antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211191", "l": "Association of DFF with alpha:beta importin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16360", "l": "A + succinate <=> AH2 + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163625", "l": "Glucagon binds to Glucagon receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18685", "l": "H(+) + NADPH + O2 + pentachlorophenol = 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805470", "l": "AMPK phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62986", "l": "hexadecanoate + NH4(+) => H2O + hexadecanamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2514790", "l": "Elastin degradation by MMP14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65461", "l": "acetyl-CoA + hexan-1-ol => CoA + hexyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68969", "l": "mandelate + O2 => H2O2 + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090079", "l": "GLB1 hydrolyses linker chain(2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56671", "l": "7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102302", "l": "mycinamicin VI 2''-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + mycinamicin VI <=> S-adenosyl-L-homocysteine + mycinamicin III(1+) + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36558", "l": "eicosanoyl-CoA + sphinganine <=> CoA + H(+) + N-eicosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32750", "l": "ethanolamine(in) <=> ethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18013", "l": "H2O + N(5)-ethyl-L-glutamine = ethylamine + L-glutamate", "d": []}, {"i": "EC:3.5.1.65", "l": "\"theanine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67375", "l": "H2O + L-seryl-L-threonine <=> L-serine + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37640", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74730", "l": "acetyl-CoA + 10 H(+) + holo-[polyketide synthase] + 5 malonyl-CoA + 5 NADPH <=> 5 CO2 + 6 CoA + dodecapentaneoyl-[polyketide synthase] + 5 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070594", "l": "juvenile hormone response element binding", "d": ["Binding to a juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443783", "l": "Interaction of NUMB with L1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61653", "l": "2,3-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] => 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2317332", "l": "PIP3 recruits AKT to the membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944497", "l": "PTEN mRNA translation is negatively regulated by microRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051063", "l": "CDP reductase activity", "d": ["Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67592", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O = (R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029460", "l": "PAK1 phosphorylates LIMK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50783", "l": "NADP(+) + octanal <=> (2E)-octenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429036", "l": "SLC2A9 transports Fru, Glc, urate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072591", "l": "citrate-L-glutamate ligase activity", "d": ["Catalysis of the reaction: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5622134", "l": "CRABP1 binds atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-555065", "l": "Formation of clathrin coated vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451366", "l": "Activation of p38MAPK by DSCAM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866851", "l": "CFTR transits to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.5.2", "l": "\"L-cysteine S-thiosulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48229", "l": "a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] => a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53039", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58634", "l": "glyoxylate + tetradecamide => N-tetradecanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51884", "l": "L-proline betaine = D-proline betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52375", "l": "17beta-estradiol + 3'-phosphoadenylyl sulfate <=> 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15049", "l": "GDP-alpha-D-glucose + H2O = D-glucose + GDP + H(+)", "d": []}, {"i": "EC:3.2.1.42", "l": "\"GDP-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.68", "l": "\"geranyl diphosphate phosphohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982017", "l": "Active G alpha (q) binds RGS proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43703", "l": "(2E,6E)-farnesoate + S-adenosyl-L-methionine <=> methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56188", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696358", "l": "TREM,CD300 binds lipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57690", "l": "cob(II)inamide-[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)inamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13774", "l": "(S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase] => (S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20085", "l": "a flavonol 3-O-beta-D-glucoside + malonyl-CoA = a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}, {"i": "EC:2.3.1.116", "l": "\"flavonol-3-O-beta-glucoside O-malonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2167942", "l": "Collagen type XIII ectodomain shedding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19429", "l": "[beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.11.15", "l": "\"[beta-adrenergic-receptor] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46087", "l": "H2O + sn-glycerol 1-phosphate <=> glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51169", "l": "(R)-adrenaline + H2O + O2 => (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31789", "l": "(13R)-edaxadiene + diphosphate => H2O + tuberculosinyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25196", "l": "(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) <=> 3-methylcatechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24768", "l": "7(1)-hydroxychlorophyllide a + NAD(+) = chlorophyllide b + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60999", "l": "H2O + L-leucine + O2 <=> 4-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41115", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656382", "l": "TGFBR2 does not recruit TGFBR1 LBD Mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65880", "l": "1-hydroxy-5alpha-androstan-3,17-dione + A = 5alpha-androstan-1,3,17-trione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "61.330711238774875", "identifiers": [{"i": "GO:0016835", "l": "carbon-oxygen lyase activity", "d": ["Catalysis of the breakage of a carbon-oxygen bond."]}, {"i": "EC:4.2.-.-", "l": "\"Carbon-oxygen lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801195", "l": "STEAP3 binds BNIP3L (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928588", "l": "EPHBs binds PTK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3785684", "l": "Fibronectin degradation by CTSG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.7.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64325", "l": "(11Z)-octadecenoyl-CoA + cholesterol => cholesteryl (11Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66038", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.100", "l": "\"[myelin-proteolipid] O-palmitoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65964", "l": "ATP + H2O + taurocholate(out) = ADP + H(+) + phosphate + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10161", "l": "L-iditol + NAD(+) => H(+) + keto-L-sorbose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21994", "l": "CoA + H(+) + N(6)-acetyl-L-lysyl-[histone] => acetyl-CoA + L-lysyl-[histone]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64634", "l": "butyl acetate + CoA => acetyl-CoA + butan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55542", "l": "40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate => 40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5336184", "l": "GPR37L binds prosaposin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007640", "l": "RBBP4 gene expression is inhibited by E2F6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35636", "l": "an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose => an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21212", "l": "H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] = 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351456", "l": "Association of gamma H2AX and NBS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034561", "l": "1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity", "d": ["Catalysis of the reaction: 1,2-bis(4-hydroxyphenyl)-2-propanol = 4,4'-dihydroxy-alpha-methylstilbene + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67774", "l": "a 5'-end dephospho-ribonucleoside-RNA + phosphate => a 5'-end 5'-monophospho-ribonucleoside-RNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419426", "l": "Cannabinoid receptors can bind cannabinoids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28151", "l": "acetyl-CoA + spermidine => CoA + H(+) + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24073", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696997", "l": "USP24 deubiquitinates DDB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21981", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67981", "l": "beta-zeacarotene => 7,8-dihydro-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421179", "l": "inosine 5'-monophosphate (IMP) + H2O => inosine + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928591", "l": "EPH:EFN tetramers oligomerise (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69398", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP] => a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047709", "l": "bis(2-ethylhexyl)phthalate esterase activity", "d": ["Catalysis of the reaction: bis(2-ethylhexyl)phthalate + H2O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12237", "l": "H2O + NADP(+) + nicotinate => 6-hydroxynicotinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72494", "l": "citrate(out) + maleate(in) <=> citrate(in) + maleate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003871", "l": "5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60974", "l": "H(+) + hexanal + NADH => hexan-1-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578717", "l": "BCDIN3D dimethylates 5' phosphate of pre-miR-145 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166175", "l": "TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5444516", "l": "Formation of MSH2:MSH6 Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34087", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol = a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938108", "l": "SERPINB13 binds cathepsin L (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375302", "l": "Kinetochore capture of astral microtubules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56664", "l": "7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610726", "l": "The IFT-A complex recruits TULP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016019", "l": "peptidoglycan immune receptor activity", "d": ["Combining with a peptidoglycan and transmitting the signal to initiate an innate immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18409", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48013", "l": "4-methyl-5-nitrocatechol + NADPH + O2 => 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20527", "l": "ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate => ATP + ethylamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54578", "l": "an adenosine in tRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050531", "l": "mannosyl-3-phosphoglycerate phosphatase activity", "d": ["Catalysis of the reaction: 2-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51769", "l": "2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate => 4-prenylphlormethylbutanophenone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24411", "l": "adenosine + H(+) + H2O <=> inosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617927", "l": "FOXO4 binds ATXN3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10409", "l": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA => 3-oxopristanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3785711", "l": "Telomere shortening during replicative exhaustion (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090683", "l": "GPCR sweet taste receptor activity", "d": ["A G protein-coupled receptor activity that is responsible for the sense of sweet taste."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75494", "l": "25-hydroxyvitamin D3 sulfate(out) + n H(+)(out) <=> 25-hydroxyvitamin D3 sulfate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48182", "l": "(2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418549", "l": "PKG1 phosphorylates BK channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57127", "l": "2-oxoglutaramate <=> 2-hydroxy-5-oxoproline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602466", "l": "Activation of MT-MMPs by FURIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9669893", "l": "KIT binds type I TKIs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66817", "l": "2 Na(+)(in) + tetrahydroxoborate(in) => 2 Na(+)(out) + tetrahydroxoborate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54249", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34725", "l": "15-methylhexadecasphing-4-enine + phosphate => 15-methylhexadecasphing-4-enine 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22917", "l": "4'-hydroxyacetophenone + H(+) + NADPH + O2 => 4-acetoxyphenol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635861", "l": "NUMB:ITCH binds GLI1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46142", "l": "(22R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211193", "l": "Homodimerization  of DFF40 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660536", "l": "SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218821", "l": "PDK1 phosphorylates PKC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49486", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977250", "l": "Autophosphorylation of IRAK4 bound to activated TLR5 or 15 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67756", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67434", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74089", "l": "ADP + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74310", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + NAD(+) <=> 12alpha-hydroxy-3-oxochola-4-en-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0004675", "l": "transmembrane receptor protein serine/threonine kinase activity", "d": ["Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30147", "l": "FADH2 + NAD(+) = FAD + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15469", "l": "1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide", "d": []}, {"i": "EC:5.3.1.16", "l": "\"1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51497", "l": "a sphingoid base + ATP => a sphingoid 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32549", "l": "(1R,5R)-sabinene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62995", "l": "H2O + tetradecamide <=> NH4(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19805", "l": "a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57054", "l": "CO2 + L-erythrulose => 3-oxoisoapionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.6", "l": "\"dipeptidyl-dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6802973", "l": "PLK3 phosphorylates CDC25C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62603", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047433", "l": "branched-chain-2-oxoacid decarboxylase activity", "d": ["Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + H+ = 2-methylbutanal + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873923", "l": "STARD10 binds LPCAT1 and PC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35141", "l": "CO2 + 2 CoA + demethoxycurcumin => (E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46411", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48371", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52278", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate => (6S)-5,6,7,8-tetrahydrofolate + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964284", "l": "BTK in active Gq-BTK complex is activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797961", "l": "CHDH oxidises Cho to BETALD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45958", "l": "(9Z)-octadecenoyl-CoA(out) => (9Z)-octadecenoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5220959", "l": "TDG excises 5-formylcytosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102550", "l": "2-methyl-6-geranylgeranyl-1,4-benzoquinol methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 2-methyl-6-geranylgeranyl-1,4-benzoquinol <=> S-adenosyl-L-homocysteine + 2,3-dimethyl-6-geranylgeranyl-1,4-benzoquinol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004846", "l": "urate oxidase activity", "d": ["Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42773", "l": "guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937814", "l": "RUNX3 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964274", "l": "G alpha (12) binds BTK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21735", "l": "chorismate + L-glutamine <=> anthranilate + H(+) + L-glutamate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49485", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53479", "l": "1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61706", "l": "AMP + diphosphate + L-seryl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10145", "l": "a ribonucleoside 3'-phosphate + H2O => a ribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72838", "l": "3',3'-cUAMP + H2O <=> H(+) + U[3'-5']pAp[3']", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48451", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0005044", "l": "scavenger receptor activity", "d": ["Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-917841", "l": "Acidification of Tf:TfR1 containing endosome (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52782", "l": "2-sulfenohercynine + NH4(+) + pyruvate => H2O + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195304", "l": "Association of beta-catenin with the destruction complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31582", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate <=> (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14149", "l": "luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP", "d": []}, {"i": "EC:2.4.1.190", "l": "\"luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61542", "l": "ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71434", "l": "3,3',5'-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) <=> 3,3',5'-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164943", "l": "Nef mediated activation of the T-cell receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56821", "l": "AH2 + cyclooctat-9-en-7-ol + O2 => A + cyclooctat-9-ene-5,7-diol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55302", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46558", "l": "7-dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + lathosterol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19752", "l": "[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50418", "l": "H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29676", "l": "glycerol(in) => glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55635", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.99.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645428", "l": "ALPK1 binds ADP-heptose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23567", "l": "2 columbamine + O2 <=> 2 berberine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34818", "l": "2 NADP(+) + tetrahydrocurcumin <=> curcumin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64087", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) <=> 2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0001070", "l": "RNA-binding transcription regulator activity", "d": ["A transcription regulator activity that modulates the transcription of specific gene sets via selective and non-covalent binding to a specific RNA sequence. This function is known to occur in phages and viruses, for example the lambda N and the HIV tat proteins are necessary to allow RNA polymerase to read through terminator sequences."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445705", "l": "Release Of ADP From Myosin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73831", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730843", "l": "Phosphorylation of LAT by p-SYK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668404", "l": "TNFA binds TNFR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20655", "l": "cucurbitacin B + H(+) + NADH => 23,24-dihydrocucurbitacin B + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624494", "l": "RAF1 binds p21 RAS:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51147", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 <=> (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350058", "l": "Formation of CSL NCOR corepressor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604732", "l": "Autocatalytic activation of proMMP13 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57611", "l": "(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) <=> 3-chlorocatechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200396", "l": "Creatine transport across the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.2.4", "l": "\"NADPH--hemoprotein reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174741", "l": "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10245", "l": "4-fumarylacetoacetate + H2O => acetoacetate + fumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12863", "l": "NH4(+) + xanthosine => guanosine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102693", "l": "UDP-glucose:kinetin 7-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + kinetin <=> H+ + kinetin-7-N-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70596", "l": "GOT2 dimer deaminates L-Asp (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034545", "l": "fumarylpyruvate hydrolase activity", "d": ["Catalysis of the reaction: fumarylpyruvate + H2O = fumarate + pyruvate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813740", "l": "GDE1 hydrolyzes GroPIns (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12873", "l": "(R)-2-hydroxy-4-methylpentanoate + NADP(+) = 4-methyl-2-oxopentanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005367", "l": "myo-inositol:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in)."]}, {"i": "REACT:R-HSA-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390595", "l": "Calcium Binds Troponin-C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74481", "l": "(Z)-dehydrocyclopeptine + CO2 + H2O + succinate => (-)-cyclopeptine + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59886", "l": "4-chloro-L-lysine + CO2 + H2O + succinate => 2-oxoglutarate + chloride + H(+) + L-lysine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29897", "l": "ADP + H(+) + L-glutamine(in) + phosphate => ATP + H2O + L-glutamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13915", "l": "D-threonine => L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693250", "l": "RHOD binds effectors at the Golgi membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839734", "l": "AXIN mutants destabilize the destruction complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.158", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009282", "l": "CDK1 phosphorylates RUNX2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.161881760686384", "identifiers": [{"i": "GO:0000976", "l": "transcription cis-regulatory region binding", "d": ["Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032770", "l": "Translocation of YAP1 to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56329", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O => 5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75153", "l": "diphosphate + neoverrucosan-5beta-ol => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935960", "l": "RUNX1 binds the TJP1 (ZO-1) gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213241", "l": "Formation of nonameric complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43363", "l": "an N-acylsphinganine + UDP-alpha-D-glucose <=> an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696947", "l": "USP47 deubiquitinates POLB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374896", "l": "Uptake of Noradrenaline (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62005", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193655", "l": "Myelin components can interact with p75NTR:NgR:LINGO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20571", "l": "L-ornithine + urea => H2O + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432897", "l": "ILK interacts with beta-1 integrin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41459", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928625", "l": "PAKs autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32717", "l": "2-oxobutanoate + CO2 + NADH => (2R,3S)-3-methylmalate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47397", "l": "H2O + octadecanoate ester => an aliphatic alcohol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374701", "l": "Phosphorylation of DCC by Fyn (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31295", "l": "(2E)-2-hydroxypenta-2,4-dienoate = 2-oxopent-4-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380316", "l": "Association of NuMA with microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626914", "l": "α2-agonists bind ADRA2A,B,C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38735", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52535", "l": "adenosine + GTP <=> AMP + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1458463", "l": "p-AKT2 phosphorylates RGC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11375", "l": "ATP + L-aspartate + NH4(+) <=> AMP + diphosphate + H(+) + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61123", "l": "kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59535", "l": "(S)-reticuline + S-adenosyl-L-methionine <=> (S)-codamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38259", "l": "(2R,3S)-beta-methylmalyl-CoA = glyoxylate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9705584", "l": "HMGCR dimer binds statins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43987", "l": "(2E,6E)-farnesol + H(+) + NADPH + O2 <=> (2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11554", "l": "1-O-alkyl-sn-glycerol + acetate + H(+) => a 1-O-alkyl-2-acetyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034911", "l": "phthalate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: phthalate + O2 + NADH + H+ = phthalate 3,4-cis-dihydrodiol + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67692", "l": "ATP + H2O + hexadecanedioate(in) = ADP + H(+) + hexadecanedioate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57357", "l": "2-oxoglutarate + chloride + H(+) + hapalindole U + O2 => CO2 + H2O + hapalindole G + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57437", "l": "guaethol + O2 + reduced [NADH--hemoprotein reductase] => acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9660557", "l": "RAS:GTP binds RAL GDS proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420117", "l": "VEGFR2 autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379864", "l": "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672978", "l": "RAF phosphorylates MAP2K dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56201", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose => H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31871", "l": "(S)-2,3-epoxysqualene = alpha-seco-amyrin", "d": []}, {"i": "EC:5.4.99.52", "l": "\"alpha-seco-amyrin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0003943", "l": "N-acetylgalactosamine-4-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888577", "l": "Synthesis of GABA by GAD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37118", "l": "sphing-4-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20702", "l": "ADP + H(+) + lipid IVA (E. coli) => ATP + lipid A disaccharide (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655483", "l": "USP1 autocleavage (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204824", "l": "Interaction of Tie2 and Ang4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604722", "l": "Activation of proMMP9 by proteases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42670", "l": "H(+) + L-rhamnono-1,4-lactone + NADPH => L-rhamnofuranose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49567", "l": "D-sedoheptulose 7-phosphate <=> 2-epi-valiolone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10494", "l": "choline + phosphate => H2O + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27296", "l": "6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n) => D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49869", "l": "(+)-dehydrodiconiferyl acid + a quinone => (+)-dehydrodiconiferyl acid ketone + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420688", "l": "GABAB heterodimeric receptor binds GABA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944246", "l": "Association of procollagen type XXI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421508", "l": "Synthesis of ALAS1 nascent polypeptide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64101", "l": "2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + TAN-1612", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797553", "l": "Protein 4.1 binds CASK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25581", "l": "alpha-L-fucose => beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400143", "l": "Fatty acid ligands activate PPARA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196964", "l": "RFK:Mg2+ phosphorylates RIB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22050", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate => 7,8-dihydroneopterin 3'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980109", "l": "Cleavage of CNTN1:NOTCH1 complex releases NICD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080097", "l": "L-tryptophan:pyruvate aminotransferase activity", "d": ["Catalysis of the reaction: L-tryptophan + pyruvate = 3-(indol-3-yl)pyruvate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811427", "l": "COPI vesicle uncoating at the ER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11644", "l": "a (2R,3R)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51477", "l": "a ribonucleoside 5'-triphosphate + formate + H(+) => a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31627", "l": "10-deoxymethynolide + dTDP-alpha-D-desosamine = 10-deoxymethymycin + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.277", "l": "\"10-deoxymethynolide desosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31038", "l": "arabidiol <=> (S)-2,3-epoxysqualene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706336", "l": "Active FLT3 binds to SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944220", "l": "Association of procollagen type XXIII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201637", "l": "Caspase-mediated cleavage of plectin-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16048", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73163", "l": "FAD(out) + NAD(+)(in) = FAD(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202241", "l": "Recruitment of SLP-76 to Gads (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38341", "l": "(20S)-ginsenoside Rd + D-glucose => (20S)-ginsenoside Rb1 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421836", "l": "trans-Golgi Network Derived Vesicle Uncoating (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33866", "l": "menaquinone-7 + succinate <=> fumarate + menaquinol-7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28932", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate => 4-carboxy-2-hydroxy-cis,cis-muconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647994", "l": "RAS proteins are depalmitoylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-167415", "l": "G-protein alpha subunit is inactivated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047745", "l": "chlorogenate hydrolase activity", "d": ["Catalysis of the reaction: chlorogenate + H2O = (-)-quinate + cis-caffeate + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "50.862455168225409", "identifiers": [{"i": "GO:0046873", "l": "metal ion transmembrane transporter activity", "d": ["Enables the transfer of metal ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.50", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36821", "l": "3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA => (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9028730", "l": "Activated NTRK2 binds FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71873", "l": "(S)-3-hydroxybutanoate(in) + H(+)(in) => (S)-3-hydroxybutanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781905", "l": "ZRANB1 binds APC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655248", "l": "Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788867", "l": "FN3K phosphorylates ketosamines (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73070", "l": "an N(4)-(oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O <=> an oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005128", "l": "erythropoietin receptor binding", "d": ["Binding to an erythropoietin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804099", "l": "HMGB1 binds LTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047327", "l": "glycerol-3-phosphate-glucose phosphotransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + D-glucose = D-glucose 6-phosphate + glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.38", "l": "\"cathepsin K\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45713", "l": "3-dehydrocarnityl-CoA + CoA => acetyl-CoA + N,N,N-trimethylglycyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191654", "l": "c-src associates with Cx43 in gap junctions (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6802973", "l": "PLK3 phosphorylates CDC25C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41210", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52051", "l": "9-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58709", "l": "rifampicin ortho-naphthoquinone carboxamide => rifampicin para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34751", "l": "ATP + N-acyl-15-methylhexadecasphing-4-enine = ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68443", "l": "beta-cryptoxanthin + O2 <=> (3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19306", "l": "3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA => 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23396", "l": "H2O + phloretin = 1,3,5-trihydroxybenzene + H(+) + phloretate", "d": []}, {"i": "EC:3.7.1.4", "l": "\"phloretin hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40435", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57848", "l": "2-oxoglutarate + O2 + scopoletin = CO2 + fraxetin + succinate", "d": []}, {"i": "EC:1.14.11.60", "l": "\"scopoletin 8-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18724", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate <=> diphosphate + ent-13-epi-manoyl oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53580", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52266", "l": "gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine => 3-(aminomethyl)indole + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706354", "l": "Ubiquitination of FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58010", "l": "(20S)-ginsenoside Rg1 + H(+) + UDP => (20S)-ginsenoside F1 + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209357", "l": "N-HH is palmitoylated by RASP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55293", "l": "pseudouridine(54) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623018", "l": "FOXO1 binds AGRP gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654224", "l": "Activated FGFR3 binds PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53153", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33412", "l": "(S)-malyl N-acetyl-alpha-D-glucosaminide + H2O => (S)-malyl alpha-D-glucosaminide + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28845", "l": "choline(out) + H(+)(out) => choline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.1", "l": "\"cystathionine gamma-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39684", "l": "3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH => (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180630", "l": "Association of APOBEC3G with Gag (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404142", "l": "atROL binds RBP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42128", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63545", "l": "H2O + kinetensin => kinetensin-(1-8) + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31067", "l": "6-amino-2-oxohexanoate = Delta(1)-piperideine-2-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16836", "l": "2 glutathione + H2O2 <=> glutathione disulfide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63949", "l": "H2O + sphinga-4E,14Z-dienine-1-phosphate => phosphate + sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57883", "l": "3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose <=> 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53370", "l": "H(+) + NADPH + uridine(17) in tRNA => 5,6-dihydrouridine(17) in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49118", "l": "deoxyviolaceinate + H2O + NADP(+) => H(+) + NADPH + O2 + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24731", "l": "anthranilate + H(+) => aniline + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15825", "l": "AZD1979 + H2O = AZD1979 oxetane hydrolysis product + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033520", "l": "TYSND1 cleaves TYSND1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28775", "l": "dinoflagellate luciferin + O2 = H(+) + H2O + hnu + oxidized dinoflagellate luciferin", "d": []}, {"i": "EC:1.13.12.18", "l": "\"dinoflagellate luciferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38784", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31195", "l": "(3S)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49417", "l": "ADP + alpha-D-ribose 1-phosphate => alpha-D-ribose 1,5-bisphosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61868", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666001", "l": "Profilin:G-actin binds MKL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102712", "l": "gibberellin A13,oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A13 + 2-oxoglutarate + O2 <=> gibberellin A43 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163625", "l": "Glucagon binds to Glucagon receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51491", "l": "archaetidylserine + H(+) <=> archaetidylethanolamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73655", "l": "(S)-nicotine + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + 2 H(+) + N-methylmyosmine", "d": []}, {"i": "EC:1.4.2.2", "l": "\"nicotine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16833", "l": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O", "d": []}, {"i": "EC:1.11.1.9", "l": "\"glutathione peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.316418070386277", "identifiers": [{"i": "GO:0005254", "l": "chloride channel activity", "d": ["Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24539", "l": "L-tryptophan + O2 <=> N-formyl-L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018747", "l": "RHOQ GEFs activate RHOQ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72271", "l": "formate(out) + oxalate(in) = formate(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24183", "l": "2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51068", "l": "(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate = (3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0016907", "l": "G protein-coupled acetylcholine receptor activity", "d": ["Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21501", "l": "UDP-alpha-D-glucose => H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66539", "l": "A + cholest-4,6-dien-3-one + H2O <=> 25-hydroxycholest-4,6-dien-3-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61656", "l": "(2E,6E)-farnesol + ATP = (2E,6E)-farnesyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16496", "l": "glycerol 1,2-cyclic phosphate + H2O <=> glycerol 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34490", "l": "dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol <=> alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45458", "l": "dodecanoate + ethanolamine => H2O + N-dodecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55894", "l": "a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+) => a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.18", "l": "\"lycopene epsilon-cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12365", "l": "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) => a quinol + beta-nicotinamide D-riboside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36882", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73574", "l": "(E,E)-piperate + ATP + CoA <=> (E,E)-piperoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60221", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32473", "l": "(7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.79", "l": "\"pappalysin-1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174916", "l": "Formation of N-glucuronides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74572", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] => N(alpha)-acetyl-L-methionine + N-terminal L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047530", "l": "2,4-diaminopentanoate dehydrogenase activity", "d": ["Catalysis of the reaction: 2,4-diaminopentanoate + H2O + NAD(P)+ = 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41826", "l": "(3R)-hydroxyhexanoyl-[ACP] + NADP(+) => 3-oxohexanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964252", "l": "G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27602", "l": "(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate = di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20189", "l": "5,6-dihydrouracil + NAD(+) = H(+) + NADH + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50088", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362485", "l": "GHBP binds GH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28203", "l": "2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate => 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022073", "l": "Procollagen triple helix formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73737", "l": "3,5-dihydroxybenzaldehyde + 4-hydroxybenzaldehyde => O2 + trans-resveratrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72284", "l": "a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093327", "l": "EPHA binds TIAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22953", "l": "O2 + octanedioyl-CoA => (2E)-octenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9726580", "l": "PGR binds PGR agonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45361", "l": "H2O + N-(11Z-eicosenoyl)-sphinganine => (11Z)-eicosenoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1253343", "l": "WWOX binds ERBB4s80 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022141", "l": "Prolysyl oxidase activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1980125", "l": "ITCH binds DTX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198599", "l": "AKT phosphorylates MDM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0102923", "l": "3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase activity", "d": ["Catalysis of the reaction: 3'-N-debenzoyltaxol + benzoyl-CoA = H+ + paclitaxel + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32704", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => 8-hydroxycopalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33249", "l": "1-pyrroline + H2O2 + NH4(+) => O2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46548", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine", "d": []}, {"i": "EC:1.14.19.19", "l": "\"sphingolipid 10-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036433", "l": "di-trans, poly-cis-undecaprenol kinase activity", "d": ["Catalysis of the reaction: di-trans, octa-cis-undecaprenol + ATP = di-trans,octa-cis-undecaprenyl phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193653", "l": "NGF homodimer binds to p75NTR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202111", "l": "AKT1 phosphorylates eNOS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32207", "l": "(2E,4Z)-2-hydroxyhexa-2,4-dienedioate = (3Z)-2-oxohex-3-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29038", "l": "ATP + H2O + L-glutamate(out) <=> ADP + H(+) + L-glutamate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707523", "l": "Hemes bind to BACH1:MAFK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24542", "l": "AH2 + D-glucono-1,5-lactone => A + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70358", "l": "1-carboxybiuret + H(+) <=> biuret + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-606287", "l": "RSF complex binds the centromere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102597", "l": "3alpha-hydroxy-ent-sandaracopimardiene 9-beta-monooxygenase activity", "d": ["Catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 <=> oryzalexin E + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705926", "l": "AR binds AR agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21161", "l": "acetyl-CoA + ADP + oxaloacetate + phosphate => ATP + citrate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2430535", "l": "MASTL phosphorylates ENSA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54044", "l": "(2E,6E)-farnesyl diphosphate + H2O = 7-epi-alpha-eudesmol + diphosphate", "d": []}, {"i": "EC:4.2.3.169", "l": "\"7-epi-alpha-eudesmol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57863", "l": "(E)-6-hydroxyferuloyl-CoA <=> CoA + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174445", "l": "RPA binds to the Flap on the C-strand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46339", "l": "3-oxochola-4,17-dien-22-oyl-CoA + H2O <=> 17-hydroxy-3-oxochol-4-en-22-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27978", "l": "GDP-alpha-D-mannose + H2O = alpha-D-mannose 1-phosphate + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106439", "l": "L-lysine:L-arginine antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)."]}, {"i": "RHEA:70827", "l": "L-arginine(in) + L-lysine(out) = L-arginine(out) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53690", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047271", "l": "glycosaminoglycan galactosyltransferase activity", "d": ["Catalysis of the reaction: glycosaminoglycan + UDP-galactose = D-galactosylglycosaminoglycan + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428909", "l": "Activated TP receptor binds G-protein  G13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52253", "l": "a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61340", "l": "(S)-methylmalonyl-CoA + H(+) = CO2 + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70013", "l": "AMP + anthraniloyl-CoA + H(+) => 2-aminobenzoyl-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35756", "l": "NAD(+) + UDP-alpha-D-glucose => H(+) + NADH + UDP-3-oxo-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975594", "l": "PLB1 hydrolyses RPALM to atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047995", "l": "hydroxyphenylpyruvate reductase activity", "d": ["Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39063", "l": "NADP(+) + scyllo-inositol = H(+) + NADPH + scyllo-inosose", "d": []}, {"i": "EC:1.1.1.371", "l": "\"scyllo-inositol 2-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44064", "l": "hexadecanoyl-CoA + octan-1-ol = CoA + octyl hexadecanoyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16711", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34399", "l": "9-cis-beta-carotene + O2 = 9-cis-10'-apo-beta-carotenal + beta-ionone", "d": []}, {"i": "EC:1.13.11.68", "l": "\"9-cis-beta-carotene 9',10'-cleaving dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71002", "l": "(S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603784", "l": "PEX19:class I PMP binds PEX3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35516", "l": "4'''-demalonylsalvianin + malonyl-CoA => CoA + salvianin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70260", "l": "AMP(out) + phosphate(in) => AMP(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74395", "l": "2 (S)-lactate(in) + prostaglandin E1(out) = 2 (S)-lactate(out) + prostaglandin E1(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64944", "l": "dCTP + 2 H2O = dCMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74766", "l": "rhamnetin + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641206", "l": "RSPOs bind LGRs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38422", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O <=> 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030946", "l": "protein tyrosine phosphatase activity, metal-dependent", "d": ["Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. This reaction requires metal ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870289", "l": "PUS3 transforms uridine-39 to pseudouridine-39 in tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43215", "l": "adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.235", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203979", "l": "Coat Assembly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50497", "l": "acetyl-CoA + N-terminal glycyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51242", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63487", "l": "2-oxoglutarate + L-prolyl-[protein] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672957", "l": "PP2A dephosphorylates KSR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37076", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68465", "l": "2-butyloctyl sulfate + H2O => 2-butyloctan-1-ol + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222738", "l": "Carboxymycobactin gets secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16581", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2 = 2 Fe(III)-[cytochrome c] + 2 H2O", "d": []}, {"i": "EC:1.11.1.5", "l": "\"cytochrome-c peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71354", "l": "androsterone 3alpha-sulfate(out) + 2 Na(+)(out) <=> androsterone 3alpha-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391936", "l": "EP1 receptor can bind PGE2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71128", "l": "H(+)(in) + L-glutamine(out) + Na(+)(out) => H(+)(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727188", "l": "ATP4A:ATP4B binds PPIs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25026", "l": "H(+) + H2O + S-methyl-5'-thioadenosine => NH4(+) + S-methyl-5'-thioinosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19810", "l": "(S)-ureidoglycolate + 2 H(+) + H2O => CO2 + glyoxylate + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64238", "l": "atrochrysone carboxylate + H(+) + holo-[ACP] => atrochrysone carboxyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047295", "l": "geranylgeranylglycerol-phosphate geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: sn-3-O-(geranylgeranyl)glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = 2,3-di-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27404", "l": "2-hydroxychromene-2-carboxylate <=> (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371353", "l": "Soluble TNF-α binds TNFR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13080", "l": "an acyl phosphate + D-hexose <=> a carboxylate + D-hexose phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58658", "l": "a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine => a 5'-end (5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75862", "l": "Fall Back to Closed Pre-initiation Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73932", "l": "Resynthesis of excised residue by POLB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9674093", "l": "PDGFRs bind type I TKI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004439", "l": "phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018756", "l": "RHOH binds GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13900", "l": "chorismate <=> prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36304", "l": "a fatty acyl-CoA + 2 H(+) + 2 NADPH => a long-chain primary fatty alcohol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15677", "l": "5-aminopentanamide + H2O = 5-aminopentanoate + NH4(+)", "d": []}, {"i": "EC:3.5.1.30", "l": "\"5-aminopentanamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610735", "l": "NUMB binds ITCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047450", "l": "(3R)-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity", "d": ["Catalysis of the reaction: (3R)-hydroxybutanoyl-[acyl-carrier-protein] = (2E)-butenoyl-[acyl-carrier-protein] + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26226", "l": "abieta-7,13-dien-18-al + H2O + NAD(+) => abieta-7,13-dien-18-oate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917730", "l": "Cargo Recognition And Sorting (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374909", "l": "Metabolism of Noradrenaline (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76073", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out) => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31677", "l": "H(+) + NADPH + perakine => NADP(+) + raucaffrinoline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417890", "l": "P2Y5 receptor can bind to LPA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016150", "l": "translation release factor activity, codon nonspecific", "d": ["A translation release factor that is not specific to particular codons; binds to guanine nucleotides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36365", "l": "(9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+) => (9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507719", "l": "p62:MEKK3 binds to TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015612", "l": "ABC-type L-arabinose transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-arabinose(out) -> ADP + phosphate + L-arabinose(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862300", "l": "LYZ binds bacterial peptidoglycan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.264511229695032", "identifiers": [{"i": "GO:0016668", "l": "oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP."]}, {"i": "EC:1.8.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32897", "l": "2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67589", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694462", "l": "ABHD6,12 hydrolyse 3AG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034046", "l": "poly(G) binding", "d": ["Binding to a sequence of guanine residues in an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38056", "l": "CTP + phytol => CDP + H(+) + phytyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75535", "l": "FMNH2 + N-acetyl-S-methyl-L-cysteine + O2 = (R)-N-acetyl-S-methyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690461", "l": "FKBP1A binds tacrolimus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909720", "l": "IFN alpha/beta binds to IFNAR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22695", "l": "3-hydroxybenzoate + H(+) + NADH + O2 <=> 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23292", "l": "ATP + L-lombricine = ADP + H(+) + N-phospho-L-lombricine", "d": []}, {"i": "EC:2.7.3.5", "l": "\"lombricine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63741", "l": "2-phenylacetaldehyde + H(+) + NADH => 2-phenylethanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204873", "l": "Interaction of Tie2 and Shp2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210881", "l": "Dimerization of Tie2/Ang1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43732", "l": "a triacyl-sn-glycerol + H2O = 1,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140581", "l": "P-type monovalent copper transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu+(in) -> ADP + phosphate + Cu+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66809", "l": "5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH => 7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021357", "l": "PRKCI phosphorylates ELF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30863", "l": "4-O-phospho-L-tyrosine + H2O = L-tyrosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373047", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69832", "l": "campestanol + O2 + reduced [NADPH--hemoprotein reductase] => 6-deoxycathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63271", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2 <=> 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62690", "l": "2 H2O + 2 ustilaginoidin A => 4 norrubrofusarin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166538", "l": "The bound receptor dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20436", "l": "NAD(+) + xylitol <=> D-xylulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73026", "l": "pregnenolone sulfate(out) <=> pregnenolone sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13719", "l": "1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH => 2-C-methyl-D-erythritol 4-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42018", "l": "17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH => cortisone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2995388", "l": "PP2A dephosphorylates BANF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51653", "l": "D-mannonate + NAD(+) => H(+) + keto-D-tagaturonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30347", "l": "ATP + IDP = ADP + ITP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59025", "l": "H2O + trihexadecanoylglycerol => dihexadecanoylglycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10188", "l": "acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.10", "l": "\"hydroxymethylglutaryl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70971", "l": "citrate <=> isocitrate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2106625", "l": "Duplex siRNA is loaded into Argonaute (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56963", "l": "a ribonucleoside 5'-triphosphate + pyruvate <=> a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37858", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA <=> 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16813", "l": "H2O + L-kynurenine = anthranilate + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73024", "l": "pregnenolone sulfate(out) => pregnenolone sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60988", "l": "(E)-hex-2-en-1-ol + NAD(+) = (E)-hex-2-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14721", "l": "UDP-alpha-D-xylose + zeatin = H(+) + O-beta-D-xylosylzeatin + UDP", "d": []}, {"i": "EC:2.4.2.40", "l": "\"zeatin O-beta-D-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63212", "l": "5-amino-6-(D-ribitylamino)uracil + methylglyoxal = 5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64068", "l": "(R)-phenylacetylcarbinol + NAD(+) = 1-phenyl-1,2-propanedione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52272", "l": "(1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine = gramine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70418", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + H2O <=> (3,5-dihydroxyphenyl)acetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748996", "l": "GST dimers cleave AZA to 6MP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26292", "l": "2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine <=> 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33057", "l": "diphosphate + GTP + H(+) => guanosine 3'-diphosphate 5'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804741", "l": "MDM2 forms homo- or heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191830", "l": "snRNP nuclear import and release (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41927", "l": "(3R)-hydroxyoctadecanoyl-[ACP] <=> (2E)-octadecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9612501", "l": "SGK phosphorylates CREB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37101", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22036", "l": "[phosphate](n) + D-glucose = [phosphate](n-1) + D-glucose 6-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.63", "l": "\"polyphosphate--glucose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53004", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49236", "l": "N(pros)-phospho-L-histidyl-[protein](out) + sucrose = L-histidyl-[protein] + sucrose 6(G)-phosphate(in)", "d": []}, {"i": "EC:2.7.1.211", "l": "\"protein-N(pi)-phosphohistidine--sucrose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66219", "l": "asc-C7-CoA + O2 <=> asc-DeltaC7-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785213", "l": "LIPC dimer binds heparin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75081", "l": "Formation of AT-AC B Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47630", "l": "3-methylmalate + CoA + H(+) => glyoxylate + H2O + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23503", "l": "H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) <=> 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27522", "l": "2,5-dihydroxypyridine + O2 = H(+) + N-formylmaleamate", "d": []}, {"i": "EC:1.13.11.9", "l": "\"2,5-dihydroxypyridine 5,6-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380586", "l": "loading of Serotonin in synaptic vesicles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48123", "l": "ganglioside GD3 + H2O <=> ganglioside GM3 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68755", "l": "alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] <=> alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823849", "l": "Expression of GATA4 in definitive endoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71540", "l": "H(+)(out) + 2 nitrate(out) => H(+)(in) + 2 nitrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952419", "l": "SMURFs ubiquitinate RUNX3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20785", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginine => ADP-D-ribose + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44303", "l": "2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64718", "l": "acrolein + H(+) + NADPH => NADP(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69122", "l": "3-phenylpyruvate + glycine => glyoxylate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35671", "l": "(S)-5'-oxoaverantin + H(+) = (1'S,5'S)-averufin + H2O", "d": []}, {"i": "EC:4.2.1.142", "l": "\"5'-oxoaverantin cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761173", "l": "Expression of PAX8 in intermediate mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15644", "l": "H(+) + oxaloacetate <=> CO2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68182", "l": "a short-chain fatty acid + CoA + H(+) => a short-chain fatty acyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56226", "l": "3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52696", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16355", "l": "L-glutamate + sulfoacetaldehyde => 2-oxoglutarate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0008556", "l": "P-type potassium transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44122", "l": "CoA + octadecanyl hexadecanoate => hexadecanoyl-CoA + octadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66594", "l": "a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+) => 2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47557", "l": "H2O + taurodeoxycholate => deoxycholate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685531", "l": "SARS virus buds into ERGIC lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015483", "l": "long-chain fatty acid transporting porin activity", "d": ["Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."]}, {"i": "TCDB:1.B.9.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65804", "l": "a 5'-end L-tyrosylphosphate-2'-deoxynucleoside-DNA + H2O = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+) + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48676", "l": "6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44848", "l": "(9Z)-tetradecenoyl-CoA + (R)-carnitine = CoA + O-(9Z)-tetradecenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33227", "l": "(E)-4-coumarate + H(+) = 4-hydroxystyrene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853496", "l": "SCF:FBXL7 binds AURKA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809663", "l": "Formation of hair keratin fibres (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209924", "l": "Dopa is decarboxylated to dopamine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004343", "l": "glucosamine 6-phosphate N-acetyltransferase activity", "d": ["Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53146", "l": "H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.12", "l": "\"ABC-type capsular-polysaccharide transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64770", "l": "2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol => S-3-(hexan-1-ol)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047542", "l": "2-furoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-furoyl-CoA + A + H2O = 5-hydroxy-2-furoyl-CoA + AH(2) + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10605", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66654", "l": "african-1-ene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035988", "l": "Defective HLCS does not biotinylate PC:Mn2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689085", "l": "ATXN3 binds polyUb-PARK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68122", "l": "a triacylglycerol + CoA => a 1,2-diacylglycerol + a fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18796", "l": "alpha-D-ribose 1-phosphate <=> D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47302", "l": "(2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63507", "l": "daunorubicin + H(+) + NADPH <=> 13-dihydrodaunorubicin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42356", "l": "(9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64851", "l": "(3Z)-hex-3-en-1-ol + benzoyl-CoA <=> (3Z)-hex-3-en-1-yl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43433", "l": "butan-1-ol + 2 Fe(III)-[cytochrome c] => butanal + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71820", "l": "L-thyroxine(out) => L-thyroxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944236", "l": "Association of procollagen type XIV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63632", "l": "a long-chain fatty acyl-AMP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0016862", "l": "intramolecular oxidoreductase activity, interconverting keto- and enol-groups", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears."]}, {"i": "EC:5.3.2.-", "l": "\"Interconverting keto- and enol-groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176175", "l": "Stalling of DNA replication fork and RPA binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27417", "l": "2 Fe(III)-[cytochrome] + H2O + nicotinate = 6-hydroxynicotinate + 2 Fe(II)-[cytochrome] + 2 H(+)", "d": []}, {"i": "EC:1.17.2.1", "l": "\"nicotinate dehydrogenase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24303", "l": "2 cob(I)yrinate a,c diamide + FMN + 3 H(+) <=> 2 cob(II)yrinate a,c diamide + FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14358", "l": "ATP + riboflavin => ADP + FMN + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086204", "l": "IBSP binds collagen type I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59129", "l": "(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP => 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961665", "l": "PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-377644", "l": "Release of CSK from SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193641", "l": "IKK-beta is recruited (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66505", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53589", "l": "NAD(+) + resolvin D2 => 16-oxoresolvin D2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848023", "l": "Activated PTK6 binds STAP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37084", "l": "[sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine => [sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.61", "l": "\"diadenosine hexaphosphate hydrolase (ATP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11186", "l": "beta-alanine + CO2 + NH4(+) => 3-(carbamoylamino)propanoate + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70831", "l": "L-arginine(in) + L-leucine(out) + Na(+)(out) = L-arginine(out) + L-leucine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75377", "l": "inosine(out) => inosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n4", "l": "\"(-)-trans-carveol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754130", "l": "CDK4 inhibitors bind CDK4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622386", "l": "LEF1 binds the promoter of the CEBPA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11516", "l": "H2O + succinyl-CoA = CoA + H(+) + succinate", "d": []}, {"i": "EC:3.1.2.3", "l": "\"succinyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32941", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29465", "l": "K(+)(out) => K(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52887", "l": "H2O + N-phenylhydroxylamine + 2 NADP(+) <=> 2 H(+) + 2 NADPH + nitrobenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112435", "l": "Formation of Elongin BC complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36324", "l": "(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH => (9Z)-octadecen-1-ol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18644", "l": "a menaquinone + H2 <=> a menaquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70522", "l": "(R)-octopamine + S-adenosyl-L-methionine <=> (R)-synephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102251", "l": "all-trans-beta-apo-10'-carotenal cleavage oxygenase activity", "d": ["Catalysis of the reaction: 10'-apo-beta-carotenal + O2 <=> 13-apo-beta-carotenone + 4-methylocta-2,4,6-trienedial."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69478", "l": "CoA + H(+) + N(6)-acetyl-L-lysine => acetyl-CoA + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16297", "l": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.210", "l": "\"3beta-(or 20alpha)-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20684", "l": "cis-zeatin + UDP-alpha-D-glucose <=> H(+) + O-beta-D-glucosyl-cis-zeatin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75423", "l": "(R,S)-butane-2,3-diol + NAD(+) = (R)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51203", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine <=> H2O + N-retinylidene-N-retinylphosphatidylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080079", "l": "cellobiose glucosidase activity", "d": ["Catalysis of the reaction: D-cellobiose + H2O = 2 D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61590", "l": "ADP + amicoumacin A 2-phosphate + H(+) => amicoumacin A + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983285", "l": "RAD51B binds RAD51C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16266", "l": "O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate => 5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18260", "l": "coproporphyrinogen III + 2 H(+) + O2 <=> 2 CO2 + 2 H2O + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724745", "l": "PLG(20-810) binds aprotinin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395340", "l": "Formation of hydroxyallysine by LOX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44851", "l": "(9Z)-tetradecenoyl-CoA + (R)-carnitine <=> CoA + O-(9Z)-tetradecenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45258", "l": "hexadecanoate(in) => hexadecanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17769", "l": "choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.7", "l": "\"choline monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295613", "l": "SPRY2 binds GRB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10540", "l": "7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde", "d": []}, {"i": "EC:4.1.2.25", "l": "\"dihydroneopterin aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638845", "l": "CERK phosphorylates CERA to form C1P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27543", "l": "methanol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634446", "l": "GFI1 gene expression is enhanced by CEBPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23582", "l": "prostaglandin I2 => prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73431", "l": "(2S)-sakuranetin + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-7-methylcarthamidin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33694", "l": "2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047594", "l": "6-beta-hydroxyhyoscyamine epoxidase activity", "d": ["Catalysis of the reaction: (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 = CO2 + H2O + H+ + scopolamine + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693478", "l": "HTR1A binds HTR1A agonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57385", "l": "(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA => (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352956", "l": "glyceraldehyde 3-phosphate + NAD+ + phosphate <=> 1,3-bisphosphoglycerate + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10446", "l": "(S)-laudanine + H(+) + S-adenosyl-L-homocysteine => (S)-reticuline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909724", "l": "Recruitment of IFNAR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156930", "l": "GTP-binding activates eEF2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12007", "l": "indoxyl + UDP-alpha-D-glucose <=> H(+) + indican + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63035", "l": "a fatty acylamide + H2O <=> a fatty acid + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047148", "l": "methylamine-glutamate N-methyltransferase activity", "d": ["Catalysis of the reaction: L-glutamate + methylammonium = N-methyl-L-glutamate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70639", "l": "H2O + N(6)-hexanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-hexanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64746", "l": "3-sulfanyl-1-hexanol + NH4(+) + pyruvate => H2O + S-3-(hexan-1-ol)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73945", "l": "FAS-mediated dimerization of procaspase-8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56153", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine => (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67496", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O = 3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701903", "l": "ALK-, STAT3- and MECP2-dependent STAT5A gene repression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444691", "l": "Prokineticin receptors bind prokineticin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141439", "l": "Release of activated MAD2 from kinetochores (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31722", "l": "11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31359", "l": "FMNH2 + nitrilotriacetate + O2 = ammoniodiacetate + FMN + glyoxylate + H2O", "d": []}, {"i": "EC:1.14.14.10", "l": "\"nitrilotriacetate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.80", "l": "\"membrane-type matrix metalloproteinase-1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694280", "l": "mRNA4 is translated to protein E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420724", "l": "CASR binds Ca2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19398", "l": "(R)-4'-phosphopantothenate + CTP + L-cysteine => CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40092", "l": "26-hydroxyhexacosanoate + NAD(+) => 26-oxohexacosanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210282", "l": "Interaction of GPVI and FceRI gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24836", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate", "d": []}, {"i": "EC:6.3.4.23", "l": "\"formate--phosphoribosylaminoimidazolecarboxamide ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25210", "l": "H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine => acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.3", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019726", "l": "mevaldate reductase (NADPH) activity", "d": ["Catalysis of the reaction: (R)-mevalonate + NADP+ = H+ + mevaldate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211191", "l": "Association of DFF with alpha:beta importin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44930", "l": "(R)-trihomocitrate + CoA + H(+) => 2-oxoheptanedioate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351936", "l": "Caspase-mediated cleavage of claspin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45003", "l": "(R)-carnitine + 3-hydroxybutanoyl-CoA <=> CoA + O-3-hydroxybutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13439", "l": "1-O-(trans-cinnamoyl)-beta-D-glucose + UDP => (E)-cinnamate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762333", "l": "ANGPTL4 binds to CDH11v (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875531", "l": "MET binds TNS4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112604", "l": "Phosphorylated STATs are released (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.7", "l": "\"kynurenine--oxoglutarate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734578", "l": "GATA4, ISL1:LDB1, TBX20, and NKX2-5 bind the MEF2C gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43793", "l": "adenosine(645) in 25S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990943", "l": "mating type region replication fork barrier binding", "d": ["Binding to the replication fork barrier found in the mating type region of fission yeast."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928654", "l": "Clathrin internalises EPH:EFN complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29445", "l": "H(+)(out) + L-alanine(out) => H(+)(in) + L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43275", "l": "ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GD2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944263", "l": "Association of procollagen type II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13763", "l": "S-adenosyl-L-homocysteine + S-methyl-L-methionine => L-methionine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66119", "l": "2-oxobutanoate + L-glutamine <=> (2S)-2-aminobutanoate + 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56677", "l": "dihydroferuloyl-CoA + NADP(+) => (E)-feruloyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006873", "l": "IL21 receptor STAT binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27478", "l": "2-oxoglutarate + O2 + thebaine => CO2 + formaldehyde + neopinone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19834", "l": "(6S)-10-formyltetrahydrofolate + H2O => (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49587", "l": "D-erythrulose 1-phosphate <=> L-erythrulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19796", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75061", "l": "chloride(in) + 2 hydrogencarbonate(out) + K(+)(out) => chloride(out) + 2 hydrogencarbonate(in) + K(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211959", "l": "CYP3A43 6b-hydroxylates TEST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450088", "l": "GLUT1 tetramer binds 4xATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004341", "l": "gluconolactonase activity", "d": ["Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31523", "l": "2-oxoglutarate + 2 H(+) + O2 = 3 CO2 + ethene + H2O", "d": []}, {"i": "EC:1.13.12.19", "l": "\"2-oxoglutarate dioxygenase (ethylene-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871373", "l": "BMX phosphorylates RUFY1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168888", "l": "Alpha1-Microglobulin binds heme (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53929", "l": "a tertiary amine + S-adenosyl-L-methionine => a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57657", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b => CMP + ganglioside GT1balpha + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032935", "l": "sterol sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of a sterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781814", "l": "USP19 deubiquitinates RNF123 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34709", "l": "5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane => AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16564", "l": "H2O + squalene <=> hopan-22-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55112", "l": "4-methyl-3-oxopentanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34854", "l": "(3S)-3-hydroxyadipyl-CoA + NAD(+) <=> 3-oxoadipyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15929", "l": "2 H(+) + 2 H2O + methylenediurea = CO2 + N-(hydroxymethyl)urea + 2 NH4(+)", "d": []}, {"i": "EC:3.5.3.21", "l": "\"methylenediurea deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210300", "l": "Interaction of DAP12 and TREM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193068", "l": "CYP17A1 17-hydroxylates PREG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28368", "l": "beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638845", "l": "CERK phosphorylates CERA to form C1P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380316", "l": "Association of NuMA with microtubules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0010285", "l": "L,L-diaminopimelate aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + LL-2,6-diaminopimelate = (S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H2O + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13353", "l": "4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol = 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": []}, {"i": "EC:2.7.8.14", "l": "\"CDP-ribitol ribitolphosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60281", "l": "L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-981539", "l": "C3b binds to cell surface (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75585", "l": "erinacine Q + H(+) + UDP => 11-O-acetylcyathatriol + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202459", "l": "Phosphorylation of Bcl10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45929", "l": "15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47995", "l": "H(+)(in) + NAD(+) + NADPH <=> H(+)(out) + NADH + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59492", "l": "(2E)-geranyl diphosphate + L-tryptophyl-[protein] = (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167674", "l": "Binding of PLCG1 to active TrkA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64669", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5631941", "l": "SESN1,2,3 bind AMPK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351407", "l": "Association of MRE11 with RAD50 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34961", "l": "(R)-carnitine(out) => (R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432946", "l": "PARVB/Affixin interacts with alpha PIX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800794", "l": "PIDD1 associates with CRADD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63330", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 2-(9Z-octadecenoyl)-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018668", "l": "3-hydroxybenzoate 4-monooxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxybenzoate + H+ + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59999", "l": "3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein] <=> (E)-cinnamate + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21506", "l": "1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde => acetoin + aldehydo-D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49446", "l": "(2-aminobenzoyl)acetate + CoA + H(+) => (2-aminobenzoyl)acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5195402", "l": "CDK1 phosphorylates LPIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53162", "l": "an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate => H2O + N-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25924", "l": "A + H2O + quinolin-8-ol = 8-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043743", "l": "LPPG:FO 2-phospho-L-lactate transferase activity", "d": ["Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5228992", "l": "ROCK1,ROCK2 are activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099582", "l": "neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration", "d": ["Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0033284", "l": "ATPase-coupled carboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carboxylic acid(out/in) = ADP + phosphate + carboxylic acid(in/out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25997", "l": "H2O + N(1)-acetylspermine + O2 => H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70673", "l": "CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein] => N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25303", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O => 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41159", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046715", "l": "active borate transmembrane transporter activity", "d": ["Enables the transport of borate across a membrane against the concentration gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955844", "l": "RBKS phosphorylates ribose to R5P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23485", "l": "A + D-cellobiose => AH2 + D-cellobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.161", "l": "\"oligosaccharide 4-alpha-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019164", "l": "pyruvate synthase activity", "d": ["Catalysis of the reaction: pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44252", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353283", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27941", "l": "(3R)-3-hydroxy-D-aspartate <=> glycine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65144", "l": "2-oxoglutarate + berkeleyone A + O2 = CO2 + H2O + preaustinoid A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6794346", "l": "NRXNs bind NLGNs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72646", "l": "1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine <=> 1,6-dimethoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23599", "l": "H2O + 2 NAD(+) + UDP-alpha-D-glucose <=> 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66900", "l": "acetyl-CoA + L-tryptophan + malonyl-CoA = CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014467", "l": "RHOG binds effectors at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24023", "l": "2-(N(omega)-L-arginino)succinate <=> fumarate + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000327", "l": "PLK1 phosphorylates BORA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451309", "l": "Edited Kainate Receptor binds glutamate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34172", "l": "L-aspartate 4-semialdehyde + pyruvate => (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9656891", "l": "OPN1SW binds 11cRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675815", "l": "PI4P transports from the Golgi membrane to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51386", "l": "CoA + H(+) + N-hexadecanoyl-serotonin => hexadecanoyl-CoA + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44520", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25615", "l": "terpentedienyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102198", "l": "L-idonate 5-dehydrogenase activity (NAD-dependent)", "d": ["Catalysis of the reaction: L-idonate + NAD = 5-dehydro-D-gluconate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873918", "l": "Transphosphorylation of JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202437", "l": "Phosphorylation of CARMA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102932", "l": "pterocarpan reductase activity", "d": ["Catalysis of the reaction: H+ + (-)-medicarpin + NADPH = (+)-vestitol + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2317332", "l": "PIP3 recruits AKT to the membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64977", "l": "8-oxo-dGTP + 2 H2O => 8-oxo-dGMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611721", "l": "β1-agonists bind ADRB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27819", "l": "L-idonate + NAD(+) => 2-dehydro-L-idonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40574", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371590", "l": "HSP70 binds to HSP40:nascent protein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749253", "l": "Formation of MCM2-7 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29141", "l": "2 H(+)(out) + H2O + menaquinone-8 + nitrite => 2 H(+)(in) + menaquinol-8 + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58375", "l": "(E)-oct-2-en-1-ol + NADP(+) <=> (2E)-octenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399996", "l": "AKT1 E17K mutant phosphorylates CREB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69063", "l": "N(delta)-hydroxy-N(omega)-methyl-L-arginine + NADH + O2 <=> H2O + N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985594", "l": "MYO9B inactivates RHOA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11728", "l": "cyclopentanol + NAD(+) = cyclopentanone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.163", "l": "\"cyclopentanol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549129", "l": "OCT1 transports organic cations into hepatic cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016438", "l": "tRNA-queuosine beta-mannosyltransferase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose + queuosine34 in tRNA(Asp) = GDP + H+ + O-4''-alpha-D-mannosylqueuosine34 in tRNA(Asp)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202969", "l": "Caspase mediated cleavage of beta-catenin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168886", "l": "Hemopexin binds Hemes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66300", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose = an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18101", "l": "cis-1,2-dihydro-3-ethylcatechol + NAD(+) = 3-ethylcatechol + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.66", "l": "\"cis-dihydroethylcatechol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68960", "l": "DNA polymerase epsilon binds at the origin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13008", "l": "(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine <=> H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12682", "l": "creatinine + H(+) + H2O => N-methylhydantoin + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15727", "l": "ascopyrone M + H2O => 1,5-anhydro-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74850", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + ATP <=> 3-diphospho-1D-myo-inositol 1,2,4,5-tetrakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73946", "l": "dehydrogriseofulvin + H(+) + NADPH <=> griseofulvin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.134", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48548", "l": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol", "d": []}, {"i": "EC:3.1.1.89", "l": "\"protein phosphatase methylesterase-1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5591052", "l": "PROCR binds Protein C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25330", "l": "(R)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009037", "l": "tyrosine-based site-specific recombinase activity", "d": ["Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61157", "l": "3'-dephospho-CoA + GTP => CoA + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102679", "l": "(5alpha)-campestan-3-one hydroxylase activity", "d": ["Catalysis of the reaction: H+ + (5alpha)-campestan-3-one + O2 + NADPH <=> (5alpha,22S,24R)-22-hydroxyergostan-3-one + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426157", "l": "SREBP1A,2 binds the MVK promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19703", "l": "a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP => a flavonol 3-O-glycoside + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53552", "l": "(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47288", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22508", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60706", "l": "a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74750", "l": "myricetin + S-adenosyl-L-methionine <=> 3-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165179", "l": "Formation of TSC1:TSC2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31817", "l": "(+)-(E)-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74742", "l": "Phosphorylation of SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52918", "l": "16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682598", "l": "ATM phosphorylates HERC2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65026", "l": "dehydrocholate + H(+) + NADPH => 7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73963", "l": "(2E,6E)-farnesyl diphosphate = aristolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65450", "l": "CoA + ethyl butanoate => butanoyl-CoA + ethanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-453200", "l": "SYK autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73810", "l": "GDP + S-adenosyl-L-methionine <=> N(7)-methyl-GDP + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692764", "l": "MAPK6 binds CCND3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-573296", "l": "Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446391", "l": "Formation of the PINCH-ILK-parvin complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24995", "l": "L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008775", "l": "acetate CoA-transferase activity", "d": ["Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211948", "l": "CYP3A4 can N-demethylate loperamide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218812", "l": "FYN phosphorylates PAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54109", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + guaia-4,6-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22200", "l": "S-adenosyl-L-methionine + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.145", "l": "\"trans-aconitate 3-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434027", "l": "Dimerization of Phospho-IRF3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868567", "l": "CDK5:p25 phosphorylates PRDX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68629", "l": "phycoerythrobilin-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61159", "l": "3'-dephospho-CoA + GTP <=> CoA + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141437", "l": "Formation of the MCC complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15276", "l": "2-oxoglutarate + L-dopa <=> 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070009", "l": "serine-type aminopeptidase activity", "d": ["Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9737780", "l": "MTTP binds lomitapide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445704", "l": "Calcium Binds Caldesmon (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63600", "l": "H2O + neocasomorphin = L-isoleucine + neocasomorphin-(1-5)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75047", "l": "N(omega),N(omega)-dimethyl-L-arginine(out) = N(omega),N(omega)-dimethyl-L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70405", "l": "CoA + H(+) + N-(9Z-hexadecenoyl)-3-oxosphinganine => (9Z)-hexadecenoyl-CoA + 3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73765", "l": "2 ADP + cyclo(L-tryptophyl-L-alanyl) + 2 H(+) + 2 phosphate => 2 ATP + L-alanine + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24055", "l": "a ubiquinone + reduced [electron-transfer flavoprotein] <=> a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58423", "l": "NADP(+) + prenol <=> 3-methyl-2-butenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14338", "l": "3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate => adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0033285", "l": "ATPase-coupled monocarboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monocarboxylic acid(out/in) = ADP + phosphate + monocarboxylic acid(in/out)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904493", "l": "tetrahydrofolyl-poly(glutamate) polymer binding", "d": ["Binding to tetrahydrofolyl-poly(glutamate) polymer."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912349", "l": "Fucosylation of Pre-NOTCH by POFUT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63033", "l": "a fatty acylamide + H2O => a fatty acid + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030379", "l": "neurotensin receptor activity, non-G protein-coupled", "d": ["Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins."]}]}
{"type": "biolink:MolecularActivity", "ic": "77.481603666032214", "identifiers": [{"i": "GO:0016896", "l": "RNA exonuclease activity, producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18195", "l": "(S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25022", "l": "CTP + riboflavin => CDP + FMN + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396399", "l": "Fibrillins bind BMPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21470", "l": "5-O-beta-D-mycaminosyltylactone + dTDP + H(+) => dTDP-alpha-D-mycaminose + tylactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16573", "l": "2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30989", "l": "(17Z)-protosta-17(20),24-dien-3beta-ol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48400", "l": "2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]", "d": []}, {"i": "EC:1.14.11.29", "l": "\"hypoxia-inducible factor-proline dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047128", "l": "1,2-dehydroreticulinium reductase (NADPH) activity", "d": ["Catalysis of the reaction: (R)-reticuline + NADP+ = 1,2-dehydroreticuline + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730840", "l": "Activation of RAC1 by VAV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016496", "l": "substance P receptor activity", "d": ["Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980123", "l": "DTX recruits beta-arrestin (ARRB) to NOTCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51806", "l": "diphosphate + H(+) + lupulone => deoxyhumulone + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62476", "l": "3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] = 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33179", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": []}, {"i": "EC:3.1.4.11", "l": "\"phosphoinositide phospholipase C\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380294", "l": "Loss of C-Nap-1 from centrosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418904", "l": "A1 and A3 receptors bind adenosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23626", "l": "a uridine in tRNA + H(+) + NADPH => a 5,6-dihydrouridine in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54772", "l": "ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide = 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70320", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O => 1D-myo-inositol 3,4-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30921", "l": "(3E)-3,4-didehydrorhodopin + AH2 => A + rhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008054", "l": "IL1F10 binds IL1RAPL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474266", "l": "Formation of collagen fibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36874", "l": "(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58429", "l": "(E,E)-2,4-hexadien-1-ol + NADP(+) => (E,E)-2,4-hexadienal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202604", "l": "Formation of a heteromeric BMP receptor complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71437", "l": "an aromatic L-alpha-amino acid(out) + L-thyroxine(in) => an aromatic L-alpha-amino acid(in) + L-thyroxine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066785", "l": "Retranslocation of DHA back to ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0005283", "l": "amino acid:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685607", "l": "Sialic acid binds SIGLEC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20689", "l": "chlorogenate + H2O = (E)-caffeate + H(+) + L-quinate", "d": []}, {"i": "EC:3.1.1.42", "l": "\"chlorogenate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52539", "l": "adenosine + dGTP <=> AMP + dGDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47679", "l": "ATP + N-acetyl-D-galactosamine <=> ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61718", "l": "ADP + D-galactofuranose(in) + H(+) + phosphate => ATP + D-galactofuranose(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16959", "l": "GMP + H(+) => 3',5'-cyclic GMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013024", "l": "RHOB binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33753", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56375", "l": "3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 <=> 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372819", "l": "PCK2 phosphorylates OA to yield PEP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42364", "l": "2 a 2-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47225", "l": "dehydroepiandrosterone 3-sulfate + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxydehydroepiandrosterone 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4332236", "l": "CBL neddylates TGFBR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912406", "l": "p53 positively regulates transcription of MIR34 microRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139898", "l": "Caspase-8 activates BID by cleavage (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68218", "l": "1,2-dihexanoyl-3-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 1,2-dihexanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28530", "l": "H2O + XMP = phosphate + xanthosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28399", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate => L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47387", "l": "4-acetoxyphenol + H2O <=> acetate + H(+) + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030559", "l": "rRNA pseudouridylation guide activity", "d": ["Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41284", "l": "H2O + N-tetracosanoyl-sphing-4-enine => sphing-4-enine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58204", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine = dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16629", "l": "(S)-malyl-CoA = acetyl-CoA + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730841", "l": "Phosphorylation and activation of VAV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74554", "l": "H2O + L-seryl-tRNA(Ser) <=> L-serine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070282", "l": "pyridoxine binding", "d": ["Binding to pyridoxine, 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8963851", "l": "VD3 dissociates from GC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71665", "l": "a menaquinol + fumarate + 2 H(+)(in) => a menaquinone + 2 H(+)(out) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23269", "l": "guanidinoacetate + H2O => glycine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43646", "l": "3-oxohexadecanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42873", "l": "N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18456", "l": "[(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O <=> [(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9010815", "l": "SLITs bind keratan sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10733", "l": "ATP + firefly D-luciferin + O2 => AMP + CO2 + diphosphate + firefly oxyluciferin + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16693", "l": "alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal", "d": []}, {"i": "EC:5.5.1.10", "l": "\"alpha-pinene-oxide decyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28851", "l": "melibiose(in) + Na(+)(in) = melibiose(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69875", "l": "6-deoxocastasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxycastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.304", "l": "\"poly[(R)-3-hydroxyalkanoate] polymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65248", "l": "AH2 + 5 H(+) + 5 malonyl-CoA = 6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033530", "l": "TYSND1 cleaves HSD17B4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39812", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15016", "l": "3alpha(S)-strictosidine + H2O <=> secologanin + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54285", "l": "H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-octadecanoylsphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30322", "l": "H(+) + NADH + O2 + theobromine <=> 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25698", "l": "H(+) + N,N-dihydroxy-L-hexahomomethionine = (E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0140296", "l": "general transcription initiation factor binding", "d": ["Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0047453", "l": "ATP-dependent NAD(P)H-hydrate dehydratase activity", "d": ["Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + 3 H+ + NADH + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452515", "l": "Expression of STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187575", "l": "Ubiquitination of phospho-p27/p21 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14705", "l": "2 CoA + NADP(+) = CoA-disulfide + H(+) + NADPH", "d": []}, {"i": "EC:1.8.1.14", "l": "\"CoA-disulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49380", "l": "5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46551", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27763", "l": "CTP + H2O => CMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59017", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) => CO2 + cycloeucalenone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13698", "l": "ATP + D-ribose => ADP + D-ribose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029451", "l": "Activation of RAC1 by VAV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296244", "l": "SUCNR1 binds SUCCA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73596", "l": "dCMP + H2O => dUMP + NH4+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140987", "l": "ATP:inorganic phosphate antiporter activity", "d": ["Enables the transfer of ATP from one side of a membrane to the other according to the reaction: ATP(out) + inorganic phosphate(in) = ATP(in) + inorganic phosphate(out)."]}, {"i": "RHEA:65840", "l": "ATP(out) + Mg(2+)(out) + phosphate(in) = ATP(in) + Mg(2+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41177", "l": "methyl-Co(III)-[dimethylamine-specific corrinoid protein] + methylamine => Co(I)-[dimethylamine-specific corrinoid protein] + dimethylamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11935", "l": "2-hydroxy-2-methylpropanenitrile <=> acetone + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64476", "l": "4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate = 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38640", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74741", "l": "7,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine => 3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22628", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.6", "l": "\"phosphoribosylaminoimidazolesuccinocarboxamide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42924", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.198", "l": "\"16S rRNA (cytidine(1402)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49334", "l": "2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851988", "l": "BTN2A2 binds T cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033711", "l": "4-phosphoerythronate dehydrogenase activity", "d": ["Catalysis of the reaction: 4-phospho-D-erythronate + NAD+ = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70368", "l": "3-oxosphinganine + octanoyl-CoA => CoA + H(+) + N-octanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46037", "l": "2'-deoxycytidine + UTP => dCMP + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798749", "l": "Exocytosis of specific granule lumen proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42825", "l": "2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 => H2O + 2 NAD(+) + tetracenomycin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30829", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640316", "l": "DeHA hydrolyses to threonate and oxalate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15363", "l": "a dolichyl D-xylosyl phosphate + UDP => a dolichyl phosphate + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928656", "l": "gamma-secretase cleaves EPHB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70614", "l": "L-lysyl-[protein] + tetradecanoyl-[ACP] <=> H(+) + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247839", "l": "Retromer associates with WLS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682026", "l": "MRN bound to shortened telomeres activates ATM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28371", "l": "oxaloacetate + phosphate => hydrogencarbonate + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66558", "l": "5-dopaminyl-L-glutamyl-[protein] + NH4(+) => dopamine + L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33874", "l": "(S)-2-ureidoglycine + H2O <=> glyoxylate + NH4(+) + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72842", "l": "ADP(out) + CoA(in) <=> ADP(in) + CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.7", "l": "\"Glu-Glu dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11837", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine => CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568737", "l": "AP-1 transcription factor binds IL1A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015498", "l": "pantothenate:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12693", "l": "3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)", "d": []}, {"i": "EC:2.5.1.52", "l": "\"L-mimosine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045439", "l": "isopenicillin-N epimerase activity", "d": ["Catalysis of the reaction: isopenicillin N = penicillin N."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199576", "l": "KIR3DL2 interacting with HLA-A3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12848", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O <=> [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10619", "l": "(2R,3S)-catechin + H2O + NADP(+) <=> (2R,3S,4S)-leucocyanidin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40628", "l": "H2O + trihexadecanoylglycerol => 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964619", "l": "PAK1 binds ARHGEF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36446", "l": "dihydrochanoclavine-I aldehyde <=> 6,8-dimethyl-6,7-didehydroergoline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61669", "l": "ATP + CoA + salicylate => 2-hydroxybenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210430", "l": "Release of L-Glutamate at the synapse (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9604308", "l": "NICD4 traffics to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66720", "l": "ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in) = ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75503", "l": "glycocholate(out) + n H(+)(out) = glycocholate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26207", "l": "4-nitrocatechol + H2O + NADP(+) => 4-nitrophenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61056", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051116", "l": "cobaltochelatase activity", "d": ["Catalysis of the reaction: ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 4 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28943", "l": "glycine betaine(in) = glycine betaine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74029", "l": "L-alanine(out) + L-threonine(in) => L-alanine(in) + L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009675", "l": "high-affinity sulfate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66266", "l": "diphosphate + nonanoyl-AMP => ATP + H(+) + nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41679", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + ATP <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70971", "l": "citrate <=> isocitrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649856", "l": "Oxidative damage to the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-350769", "l": "trans-Golgi Network Coat Activation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15656", "l": "ATP + beta-D-fructose 6-phosphate <=> ADP + beta-D-fructose 2,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951966", "l": "EP300 acetylates RUNX3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59099", "l": "monoglucosyl-enterobactin + UDP-alpha-D-glucose <=> diglucosyl-enterobactin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1964496", "l": "STING binds TRIM32 or TRIM56  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672969", "l": "Phosphorylation of RAF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53267", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50890", "l": "an N-acyl-sphingoid base + phosphate => an N-acylsphingoid base 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75649", "l": "(8R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24952", "l": "1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate", "d": []}, {"i": "EC:2.7.1.170", "l": "\"anhydro-N-acetylmuramic acid kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14003", "l": "CoA + glycocholate + H(+) => choloyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50803", "l": "glutathione + prostaglandin A2 <=> prostaglandin A2-S-(S)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56098", "l": "[protein]-C-terminal Gly-Gly-AMP + diphosphate => [protein]-C-terminal Gly-Gly + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372819", "l": "PCK2 phosphorylates OA to yield PEP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38565", "l": "1-O-hexadecyl-sn-glycerol + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57817", "l": "dGMP + H2O => 2-deoxy-D-ribose 5-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57468", "l": "(E)-ferulate + UDP-alpha-D-glucose = 1-O-[(E)-feruloyl]-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12834", "l": "an N-acyl-D-glutamate + H2O => a carboxylate + D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22770", "l": "4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one => 4-nitrophenyl-3-ketovalidamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862733", "l": "CCR2, CCR3 bind CCL13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340124", "l": "CSN polymer binds CaPO4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52640", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA = (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034851", "l": "2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + CoASH = pivalyl-CoA + propanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12808", "l": "(S)-canadine + S-adenosyl-L-methionine <=> (S)-cis-N-methylcanadine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42402", "l": "L-histidyl-[protein] + lactose 6-phosphate(in) => lactose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173705", "l": "C5b binds C6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38677", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733969", "l": "Bile salts dissociate from FABP6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786092", "l": "IL4:IL4R:JAK2 binds IL2RG:JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109857", "l": "MAP2K1 binds MAPK3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15452", "l": "homogentisate + O2 <=> 4-maleylacetoacetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382096", "l": "Formation of NR-NCOR Corepressor Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28358", "l": "FAD + H(+) + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209823", "l": "Tyrosine is hydroxylated to dopa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16338", "l": "a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase] => a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15285", "l": "AMP + dimethylallyl diphosphate = diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate", "d": []}, {"i": "EC:2.5.1.27", "l": "\"adenylate dimethylallyltransferase (AMP-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16657", "l": "H2O + inosine = D-ribose + hypoxanthine", "d": []}, {"i": "EC:3.2.2.2", "l": "\"inosine nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944219", "l": "Association of procollagen type XVI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617595", "l": "SGTA binds mislocalized membrane protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110322", "l": "Formation of Pol zeta complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45169", "l": "2 (E)-sinapoyl-CoA + spermidine => 2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69299", "l": "CDT1 binds geminin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34417", "l": "(1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O => (1R,4R)-bornane-2,5-dione + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24522", "l": "(S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH => H2O + L-saccharopine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69311", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate <=> phenylacetonitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688456", "l": "MLKL binds FLOT1, FLOT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43294", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30550", "l": "(3S)-hydroxyhexanoyl-CoA <=> (2E)-hexenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856189", "l": "TNFSF8 binds TNFRSF8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805546", "l": "Keratin type I binds keratin type II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611852", "l": "ADRB3 bind ADR,NAd (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15283", "l": "5alpha-cholest-8-en-3beta-ol => lathosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48775", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a <=> 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21837", "l": "D-arabinonate => 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24317", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25448", "l": "(2E,6E)-farnesyl diphosphate = (+)-guaia-6,9-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69016", "l": "3alpha-hydroxy-5beta-pregnan-20-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798081", "l": "TP53 family members stimulate CASP1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19412", "l": "cholate + NAD(+) <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5444511", "l": "Formation of MSH2:MSH3 Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62454", "l": "AMP + diphosphate + L-glutamyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57676", "l": "4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase] = 4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73016", "l": "D-leucine(in) => D-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030794", "l": "(S)-coclaurine-N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209252", "l": "CI75 inhibits transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43172", "l": "guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.309", "l": "\"18S rRNA (guanine(1575)-N(7))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74041", "l": "D-alanine(in) + L-alanine(out) => D-alanine(out) + L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74760", "l": "isorhamnetin + S-adenosyl-L-methionine => 3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44073", "l": "1-O-alkyl-2-acyl-sn-glycerol + ATP => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52250", "l": "12 H(+) + 4 MnO2 => 6 H2O + 4 Mn(3+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417842", "l": "P2Y10 receptor can bind to LPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873927", "l": "Release of STAT1 dimer from active receptor unit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684277", "l": "mRNA1 is translated to pp1ab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687107", "l": "MAPK4,6 translocate to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71756", "l": "2-oxoglutarate(out) + 2-oxoheptanedioate(in) => 2-oxoglutarate(in) + 2-oxoheptanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63139", "l": "adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione <=> cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-adenosylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874082", "l": "MET phosphorylates PTK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74885", "l": "GUCYs converts GTP to cGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047299", "l": "tryptophan-phenylpyruvate transaminase activity", "d": ["Catalysis of the reaction: keto-phenylpyruvate + L-tryptophan = 3-(indol-3-yl)pyruvate + L-phenylalanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218811", "l": "DOCK180:ELMO binds CRK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390846", "l": "D2D3,4 bind to DA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210282", "l": "Interaction of GPVI and FceRI gamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9724685", "l": "IgE binds omalizumab (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818574", "l": "TASP1 cleaves KMT2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72499", "l": "2-oxoglutarate(in) + prostaglandin E2(out) = 2-oxoglutarate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31239", "l": "4 H(+) + uroporphyrinogen I = 4 CO2 + coproporphyrinogen I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.29", "l": "\"aspartate/glutamate leucyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23986", "l": "7-dehydrocholesterol + H(+) + NADPH => cholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48245", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 => CMP + ganglioside GM1b + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25513", "l": "(2S)-2-amino-4-deoxychorismate + L-glutamate => chorismate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.99.1.-", "l": "\"Other isomerases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32587", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 = (3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32268", "l": "4-aminobutanoate + glyoxylate => glycine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917693", "l": "ESCRT Disassembly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65513", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2 => 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11607", "l": "[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31578", "l": "8-oxo-dGTP + H2O <=> 8-oxo-dGMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59653", "l": "D-xylotetraono-1,5-lactone + H2O => D-xylotetraonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69473", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose => a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53596", "l": "1-octadecanoyl-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-170149", "l": "Translocation of active Cdc25C to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421836", "l": "trans-Golgi Network Derived Vesicle Uncoating (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9650165", "l": "ASIC trimers bind H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050339", "l": "TTPase activity", "d": ["Catalysis of the reaction: dTTP + H2O = dTDP + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39074", "l": "dodecanedioyl-CoA + O2 <=> (2E)-dodecenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63219", "l": "7-cyano-7-carbaguanosine(15) in tRNA + L-lysine <=> 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350158", "l": "LGMN degrades GC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44792", "l": "2-demethylmenaquinol-12 + S-adenosyl-L-methionine = H(+) + menaquinol-12 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672957", "l": "PP2A dephosphorylates KSR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70440", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2 => a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32293", "l": "3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine => phosphoethanolamine + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37350", "l": "(R)-lactate + ATP + D-alanine <=> ADP + D-alanyl-(R)-lactate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13892", "l": "FAD + H2O <=> AMP + FMN + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72878", "l": "anthocyanin A7 + malonyl-CoA <=> anthocyanin A9 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938217", "l": "RUNX1 binds the SWI/SNF complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009936", "l": "RNASEL cleaves cellular ssRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097247", "l": "epigallocatechin 3-gallate binding", "d": ["Binding to epigallocatechin 3-gallate, a compound that is a gallic acid ester of a catechin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55213", "l": "(2R)-hydroxyhexadecanoyl-CoA => formyl-CoA + pentadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14137", "l": "3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine = 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)", "d": []}, {"i": "EC:2.8.2.13", "l": "\"psychosine sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052829", "l": "inositol-1,3,4-trisphosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate."]}, {"i": "REACT:R-HSA-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869694", "l": "oxPL binds CD14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33228", "l": "(E)-4-coumarate + H(+) => 4-hydroxystyrene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389381", "l": "Gads binds CD28 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.382", "l": "\"methoxylated aromatic compound--corrinoid protein Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801101", "l": "RABGGTA binds RABGGTB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22510", "l": "diphosphate + DNA(n+1) => a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69344", "l": "(E)-but-1-en-1-SO-peroxol = (Z)-butanethial oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33461", "l": "NADP(+) + zymosterol => H(+) + NADPH + zymosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928615", "l": "EFNBs bind SFKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878056", "l": "RUNX1:CBFB binds EP300 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29864", "l": "AMP + GTP => ADP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15370", "l": "2,3-dihydroxybenzoate + O2 => 2-carboxy-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52955", "l": "lithocholate + UDP-alpha-D-glucuronate <=> lithocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693347", "l": "HTR1A binds 5HT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086083", "l": "SUMOylation of ING2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67419", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473584", "l": "Collagen type III degradation by MMP15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876484", "l": "NPC2 transfers CHOL to NPC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20380", "l": "androsterone + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050681", "l": "nuclear androgen receptor binding", "d": ["Binding to a nuclear androgen receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66069", "l": "4-methyl-2-oxopentanoate + L-kynurenine => H2O + kynurenate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73264", "l": "genkwanin + S-adenosyl-L-methionine => apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25975", "l": "H2O + N(8)-acetylspermidine + O2 <=> 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38326", "l": "2 1-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001018", "l": "mitochondrial promoter sequence-specific DNA binding", "d": ["Binding to a DNA region that controls the transcription of the mitochondrial DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781953", "l": "YOD1 binds VCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75508", "l": "n H(+)(out) + taurocholate(out) => n H(+)(in) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734713", "l": "ORC6 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19814", "l": "a 2-oxocarboxylate + L-asparagine => 2-oxosuccinamate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848110", "l": "SOCS3 binds activated PTK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5603467", "l": "Activated protein C is released from PROCR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68345", "l": "ATP + GTP => 3',2'-cGAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21861", "l": "3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate => adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634850", "l": "NPAS4 binds ARNT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66199", "l": "acetyl-CoA + tryptamine <=> CoA + H(+) + N-acetyltryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19573", "l": "[phosphate](n) + ATP = [phosphate](n+1) + ADP", "d": []}, {"i": "EC:2.7.4.1", "l": "\"ATP-polyphosphate phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31779", "l": "an all-trans-retinyl ester + H2O = 13-cis-retinol + a fatty acid + H(+)", "d": []}, {"i": "EC:3.1.1.90", "l": "\"all-trans-retinyl ester 13-cis isomerohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984606", "l": "Kinesin-5 is a homotetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2464822", "l": "RDH12 reduces atRAL to atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54167", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19934", "l": "alpha-D-glucose 1-phosphate + H2O => D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10361", "l": "3,4-dihydrocoumarin + H2O => 3-(2-hydroxyphenyl)propanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34684", "l": "alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O => alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67982", "l": "7,8-dihydro-beta-carotene => beta-zeacarotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61910", "l": "2 AMP + asperphenamate + 2 diphosphate + H(+) => 2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44533", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10383", "l": "diphosphate + orotidine 5'-phosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11074", "l": "catechol + CO2 + NADP(+) + NH4(+) => anthranilate + 3 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37123", "l": "sphing-4-enine + tetracosenoyl-CoA = CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0033757", "l": "glucoside 3-dehydrogenase activity", "d": ["Catalysis of the reaction: sucrose + acceptor = 3-dehydro-alpha-D-glucosyl-beta-D-fructofuranoside + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001068", "l": "arabinoxylan binding", "d": ["Binding to arabinoxylan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22189", "l": "an (R)-2-haloacid + H2O => a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43720", "l": "juvenile hormone III carboxylate + S-adenosyl-L-methionine = juvenile hormone III + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008819", "l": "cobinamide kinase activity", "d": ["Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70750", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16203", "l": "4-aminobenzoate + H(+) + pyruvate => 4-amino-4-deoxychorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63774", "l": "1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27449", "l": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.75", "l": "\"diacylglycerol diphosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69141", "l": "N-(4-aminobutyl)-3-aminopropanal => acrolein + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202604", "l": "Formation of a heteromeric BMP receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22424", "l": "an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36858", "l": "an N-acetyl-L-cysteine-S-conjugate + H2O <=> acetate + an S-substituted L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.99", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691004", "l": "XPC binds RAD23 and CETN2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22834", "l": "N-formyl-L-glutamate + NH4(+) => H2O + N-formimidoyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72314", "l": "glutathione(in) + taurocholate(out) <=> glutathione(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35105", "l": "fusidate(out) => fusidate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210426", "l": "Glutamate synaptic vesicle docking and priming (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112755", "l": "SOCS3 binds IL6ST (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24785", "l": "3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24062", "l": "H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803935", "l": "TP53 binds the PLAGL1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.31", "l": "\"3-hydroxyisobutyrate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50066", "l": "ADP + H(+) + phosphate + taurochenodeoxycholate(out) => ATP + H2O + taurochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000155", "l": "phosphorelay sensor kinase activity", "d": ["Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009488", "l": "IL34 binds CSF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71819", "l": "L-thyroxine(out) = L-thyroxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44676", "l": "a triacyl-sn-glycerol + all-trans-retinol = a diacylglycerol + an all-trans-retinyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.264511229695032", "identifiers": [{"i": "GO:0008066", "l": "glutamate receptor activity", "d": ["Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031828", "l": "type 2C serotonin receptor binding", "d": ["Binding to a type 2C serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63813", "l": "ATP + N(8)-citryl-spermidine + spermidine => AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54126", "l": "CO2 + excited coelenteramide h monoanion + H(+) => coelenterazine h dioxetanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44063", "l": "2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA <=> 2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26133", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875523", "l": "MET binds TNS3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5159250", "l": "ATF7IP binds SETDB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982810", "l": "JAK2 phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102769", "l": "dihydroceramide glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + a dihydroceramide = UDP + H+ + a D-glucosyl-N-acylsphinganine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69754", "l": "benzylmalonyl-CoA + H(+) + O2 <=> (E)-cinnamoyl-CoA + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168947", "l": "Ligand binds to TLR10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15010", "l": "(6S)-5,6,7,8-tetrahydrofolate + NADP(+) => 7,8-dihydrofolate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47525", "l": "cholate + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203613", "l": "depalmitoylation of eNOS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75676", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72844", "l": "3'-dephospho-CoA(in) + ADP(out) => 3'-dephospho-CoA(out) + ADP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51553", "l": "D-sorbitol + NADP(+) => H(+) + L-xylo-3-hexulose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70147", "l": "6-deoxo-28-norcastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 28-norcastasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51179", "l": "cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605056", "l": "Expression of SREBF1 (SREBP1) regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793375", "l": "Expression of MSGN1 in paraxial mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19926", "l": "D-ribitol 5-phosphate + NAD(+) => D-ribulose 5-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28609", "l": "L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.1", "l": "\"anthranilate 1,2-dioxygenase (deaminating, decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851933", "l": "MET phosphorylates GAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57360", "l": "H2O + NADH = (6R)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849428", "l": "PTPN1 binds PTK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45535", "l": "H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57493", "l": "H2O + oxaloacetate + propanoyl-CoA => 2-methylcitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33313", "l": "2 AH2 + H(+) + H2O + N2 => 2 A + hydroxylamine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49275", "l": "alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] <=> calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17148", "l": "2'-hydroxy-2,3-dihydrodaidzein + NADP(+) <=> 2'-hydroxydaidzein + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54141", "l": "cytidine(49) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16001", "l": "H(+) + H2O + N(6)-methyl-AMP = IMP + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45562", "l": "D-allo-isoleucine => L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985812", "l": "NCK2 binds to ROBO1,(ROBO2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416683", "l": "SEMA3E binds to PLXND1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033775", "l": "deoxysarpagine hydroxylase activity", "d": ["Catalysis of the reaction: 10-deoxysarpagine + H+ + NADPH + O2 = H2O + NADP+ + sarpagine."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004733", "l": "pyridoxamine phosphate oxidase activity", "d": ["Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH4+ + hydrogen peroxide. This activity can also oxidize pyridoxine 5'-phosphate to  pyridoxal 5'-phosphate + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0050998", "l": "nitric-oxide synthase binding", "d": ["Binding to nitric-oxide synthase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163069", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18581", "l": "ethanolamine + H2O + O2 = glycolaldehyde + H2O2 + NH4(+)", "d": []}, {"i": "EC:1.4.3.8", "l": "\"ethanolamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604550", "l": "HEY1 gene expression is stimulated by NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984775", "l": "Kinesin-9 is a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164832", "l": "ATPase synthesizes ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350441", "l": "FLW:MYPT-75D complex dephosphorylates SQH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.135", "l": "\"glyceollin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001634", "l": "pituitary adenylate cyclase-activating polypeptide receptor activity", "d": ["A G protein-coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74780", "l": "laricitrin + S-adenosyl-L-methionine => 3,3'-O-dimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75081", "l": "Formation of AT-AC B Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69247", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate <=> 5-methylsulfinylpentyl nitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.8", "l": "\"glucosamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0050840", "l": "extracellular matrix binding", "d": ["Binding to a component of the extracellular matrix."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50100", "l": "dodecanoyl-CoA + taurine = CoA + H(+) + N-dodecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50658", "l": "2-(2-methylsulfanyl)ethylmaleate + H2O => 3-(2-methylsulfanyl)ethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51143", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 <=> (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176445", "l": "SMURF2 binds SMAD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42586", "l": "1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51277", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033736", "l": "L-lysine 6-oxidase activity", "d": ["Catalysis of the reaction: L-lysine + H2O + O2 = allysine + H2O2 + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32475", "l": "glycine + 3 S-adenosyl-L-methionine = glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.162", "l": "\"glycine/sarcosine/dimethylglycine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24515", "l": "L-serine + pyrazole <=> 3-(pyrazol-1-yl)-L-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.13", "l": "\"2-halobenzoate 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033914", "l": "xylan 1,3-beta-xylosidase activity", "d": ["Catalysis of the hydrolysis of successive xylose residues from the non-reducing termini of (1->3)-beta-D-xylans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44934", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660662", "l": "ASC binds Caspase-8 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371467", "l": "SIRT1 deacetylates HSF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008776", "l": "acetate kinase activity", "d": ["Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60510", "l": "an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine => a guanosine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38739", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195739", "l": "Palmitoylation of cysteine residues on M2 in the cis-golgi network (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25887", "l": "carbamoyl phosphate + N(2)-succinyl-L-ornithine <=> H(+) + N(2)-succinyl-L-citrulline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665998", "l": "MKL1 binds SRF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42388", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose = beta-D-gentiobiosyl crocetin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382096", "l": "Formation of NR-NCOR Corepressor Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2245218", "l": "CDK1 phosphorylates PHF8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58195", "l": "dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin <=> dihydrobisanhydrobacterioruberin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102885", "l": "alpha-cuprenene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (-)-alpha-cuprenene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218821", "l": "PDK1 phosphorylates PKC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38172", "l": "hexadecane-1,2-diol + hexadecanoyl-CoA => 2-hydroxyhexadecyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53766", "l": "allocholoyl-CoA + lithocholate => allocholate + lithocholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69847", "l": "a 5,6-dihydrouridine in RNA + NADP(+) = a uridine in RNA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23376", "l": "L-threonate + NAD(+) = 3-dehydro-D-erythronate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.129", "l": "\"L-threonate 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38186", "l": "19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.1.15", "l": "\"6-deoxy-6-sulfo-D-fructose transketolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948775", "l": "MKRN1 polyubiquitinates PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015334", "l": "high-affinity oligopeptide transmembrane transporter activity", "d": ["Enables the transfer of oligopeptide from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707516", "l": "FeHM dissociates from MetHb (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25679", "l": "ATP + O-phospho-L-serine + tRNA(Cys) => AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58078", "l": "(11Z)-eicosenoate + glycerol + H(+) => 1-(11Z-eicosenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749215", "l": "MCM8 binds CDC6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102439", "l": "3',4',5'-trimethylmyricetin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5'-trimethylmyricetin + S-adenosyl-L-methionine <=> 7,3',4',5'-tetramethylmyricetin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59939", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009485", "l": "IL34:CSF1 binds CSF1R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419049", "l": "ROCK activation by RHO (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199425", "l": "PHLPP dephosphorylates S473 in AKT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65238", "l": "3-methylbutyl acetate + CoA => 3-methylbutanol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696564", "l": "USP25 deubiquitinates DDX58 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-990526", "l": "Recruitment of ITCH and K48 ubiquitination of MAVS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220979", "l": "NOTCH1 PEST domain mutants stimulate HES1 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74739", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine = 7,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20654", "l": "23,24-dihydrocucurbitacin B + NAD(+) => cucurbitacin B + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72450", "l": "a dicarboxylate(in) + estrone 3-sulfate(out) <=> a dicarboxylate(out) + estrone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14829", "l": "hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine", "d": []}, {"i": "EC:2.5.1.47", "l": "\"cysteine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183122", "l": "Factor D cleaves C3b-bound Factor B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73261", "l": "eupatorin + H(+) + S-adenosyl-L-homocysteine => cirsiliol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015478", "l": "oligosaccharide transporting porin activity", "d": ["Enables the transfer of oligosaccharide, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53911", "l": "(2E)-butenoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24175", "l": "A + a 3-oxo-5beta-steroid <=> a 3-oxo-Delta(4)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13673", "l": "[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate", "d": []}, {"i": "EC:2.7.7.59", "l": "\"[protein-PII] uridylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60571", "l": "N-acetyl-L-tryptophan <=> N-acetyl-D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29534", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045129", "l": "NAD-independent histone deacetylase activity", "d": ["Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction does not require the presence of NAD, and represents the removal of an acetyl group from a histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35264", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46916", "l": "H2O + juvenile hormone I = H(+) + juvenile hormone I carboxylate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1369028", "l": "ABCAs mediate lipid efflux (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686359", "l": "SFTPs translocate from extracellular region to clathrin-coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25043", "l": "L-selenocysteinyl-tRNA(Sec) + 2 phosphate => H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67634", "l": "a plastoquinol + 4 H(+)(out) + 2 oxidized [2Fe-2S]-[ferredoxin] => a plastoquinone + 6 H(+)(in) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508451", "l": "PTK2B is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851988", "l": "BTN2A2 binds T cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69005", "l": "Cdc6 protein is phosphorylated by CDK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61714", "l": "2 Fe(III)-[cytochrome b5] + H2O + N(delta)-methyl-L-arginine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29132", "l": "menaquinol-8 + nitrate => H2O + menaquinone-8 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37279", "l": "ATP + H2O + L-alanyl-L-histidine(out) = ADP + H(+) + L-alanyl-L-histidine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44008", "l": "a 2-methyl-branched fatty aldehyde + H2O + NAD(+) = a 2-methyl fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592436", "l": "Initial activation of proMMP9 by MMPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937034", "l": "IRAK1 phosphorylates Pellino (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975594", "l": "PLB1 hydrolyses RPALM to atROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11347", "l": "an N-acylneuraminate + CTP <=> a CMP-N-acyl-beta-neuraminate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64498", "l": "6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + H2O + holo-[ACP] => 3,5,7,9,11-pentaoxododecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983144", "l": "Transport of Antigen peptide in to ER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48898", "l": "3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40042", "l": "2 ATP + 2 L-glutamate + N-acetyl-L-aspartate <=> 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045516", "l": "interleukin-19 receptor binding", "d": ["Binding to an interleukin-19 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50704", "l": "1-propanol + NAD(+) = H(+) + NADH + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701147", "l": "TRPV1 binds TRPV1 blockers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482770", "l": "Release of platelet secretory granule components (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28970", "l": "L-proline(in) + Na(+)(in) <=> L-proline(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794352", "l": "NRXNs binds CASK tripartite complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39003", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65621", "l": "hexadecanoyl-CoA + sphinga-(4E,8E)-dienine => CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047262", "l": "polygalacturonate 4-alpha-galacturonosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-galacturonate + 1,4-alpha-D-galacturonosyl(n) = 1,4-alpha-D-galacturonosyl(n+1) + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22541", "l": "5'-dehydroadenosine + H2O + O2 => 9-riburonosyladenine + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59266", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60282", "l": "H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51434", "l": "[(1S)-1-acetamidoethyl]phosphonate + CoA => (S)-1-aminoethylphosphonate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23917", "l": "H(+) + UDP-alpha-D-glucuronate => CO2 + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810376", "l": "ING2 binds PI5P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847534", "l": "RAB43 hydrolyses GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050505", "l": "hydroquinone glucosyltransferase activity", "d": ["Catalysis of the reaction: hydroquinone + UDP-D-glucose = H+ + hydroquinone O-beta-D-glucopyranoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-984733", "l": "Kinesin-3 is a dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71123", "l": "(E)-caffeate + ATP + H(+) + 2 malonyl-CoA = AMP + 2 CO2 + 2 CoA + diphosphate + hispidin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090489", "l": "L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating)", "d": ["Catalyzes the multi-step reaction: L-Tryptophan + 2 Oxygen + 2 NADPH + 2 H+ = Indole-3-acetaldehyde oxime + 3 H2O + 2 NADP+ + CO2. The individual reactions are: (1a) L-tryptophan + O2 + NADPH + H+ = N-hydroxy-L-tryptophan + NADP+ + H2O,(1b) N-hydroxy-L-tryptophan + O2 + NADPH + H+ = N,N-dihydroxy-L-tryptophan + NADP+ + H2O, and (1c) N,N-dihydroxy-L-tryptophan = (E)-indol-3-ylacetaldoxime + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62598", "l": "(6E)-8-oxogeranial + H(+) + NADH => (S)-8-oxocitronellyl enol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33491", "l": "2-hydroxyhexacosanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36089", "l": "1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45878", "l": "6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA => 2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140943", "l": "histone H4K20 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H+ + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine. This reaction is the addition of three methyl groups to the lysine residue at position 20 of the histone H4 protein, producing histone H4K20me3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50858", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748991", "l": "XDH oxidises 6MP to 6TU (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31812", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + viridiflorene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682377", "l": "LC3 de-lipidation by ATG4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68628", "l": "phycoerythrobilin-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit]", "d": []}, {"i": "EC:4.4.1.40", "l": "\"C-phycoerythrin beta-cysteine-48/59 phycoerythrobilin lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70675", "l": "H2O + Met-enkephalin-Arg-Phe = L-arginyl-L-phenylalanine + Met-enkephalin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71548", "l": "5-phosphomethyl-dUMP in DNA + glycine => 5-N(alpha)-glycyl-dTMP in DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696267", "l": "RND3 binds GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43289", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37390", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726509", "l": "NR3C2 binds fludrocortisone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019705", "l": "protein-cysteine S-myristoyltransferase activity", "d": ["Catalysis of the transfer of a myristoyl (systematic name, tetradecanoyl) group to a sulfur atom on a cysteine residue of a protein molecule in the reaction: tetradecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-tetradecanoyl-L-cysteinyl-[protein]."]}, {"i": "RHEA:59736", "l": "L-cysteinyl-[protein] + tetradecanoyl-CoA = CoA + S-tetradecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57358", "l": "CO2 + H2O + hapalindole G + succinate => 2-oxoglutarate + chloride + H(+) + hapalindole U + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140613", "l": "P-type manganese transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(in) = ADP + H+ + Mn2+(out) + phosphate."]}, {"i": "RHEA:66820", "l": "ATP + H2O + Mn(2+)(in) = ADP + H(+) + Mn(2+)(out) + phosphate", "d": []}, {"i": "EC:7.2.2.22", "l": "\"P-type Mn(2+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47292", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60926", "l": "CO2 + formaldehyde + L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34290", "l": "2 L-dopa + O2 <=> 2 H2O + 2 L-dopaquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191763", "l": "snRNP:Snurportin complex formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28940", "l": "H(+)(in) + xanthosine(in) => H(+)(out) + xanthosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70670", "l": "a fatty acyl-[ACP] + L-lysyl-[protein] <=> H(+) + holo-[ACP] + N(6)-(fatty acyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17301", "l": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]", "d": []}, {"i": "EC:2.7.11.4", "l": "\"[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25177", "l": "4-methyl-2-oxopentanoate + CoA + NAD(+) = 3-methylbutanoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9692376", "l": "BCL2 binds BCL2 antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62916", "l": "an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine = an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13859", "l": "a dolichyl phosphate + D-glucose + H(+) => a dolichyl beta-D-glucosyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43663", "l": "ATP + hydrogencarbonate + propanoyl-CoA <=> ADP + H(+) + methylmalonyl-CoA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35715", "l": "(2S,3S)-versiconal hemiacetal acetate + H2O = (2S-3S)-versiconal hemiacetal + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48733", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O => [CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12701", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate", "d": []}, {"i": "EC:1.17.4.2", "l": "\"ribonucleoside-triphosphate reductase (thioredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43166", "l": "7-cyano-7-carbaguanosine(15) in tRNA + guanine => 7-cyano-7-deazaguanine + guanosine(15) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430158", "l": "p-SLP-76 binds VAV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73718", "l": "UBF-1 Binds rDNA Promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0004630", "l": "phospholipase D activity", "d": ["Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825582", "l": "Expression of EPHA4 in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67569", "l": "3'-phosphoadenylyl sulfate + taurochenodeoxycholate => adenosine 3',5'-bisphosphate + H(+) + taurochenodeoxycholate 7-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781953", "l": "YOD1 binds VCP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46380", "l": "7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847534", "l": "RAB43 hydrolyses GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066782", "l": "Translocation of DPA to the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803060", "l": "DCD(63-110) is processed to DCD(63-109) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428273", "l": "SPHK1 phosphorylates SPG to S1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8953111", "l": "E2F6 binds TFDP1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047629", "l": "ADP deaminase activity", "d": ["Catalysis of the reaction: ADP + H2O = IDP + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26250", "l": "H(+) + levopimaradienol + NADPH + O2 => 2 H2O + levopimaradienal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42615", "l": "a plastoquinone + (n+1) H(+)(in) + NADPH <=> a plastoquinol + n H(+)(out) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080082", "l": "esculin beta-glucosidase activity", "d": ["Catalysis of the hydrolysis of glucosidic link in esculin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63104", "l": "H(+) + ilicicolin A epoxide + NADPH + O2 = 16-hydroxy-ilicicolin A epoxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70070", "l": "a C29-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a (22S)-22-hydroxy C29-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58750", "l": "H(+) + nectriapyrone + S-adenosyl-L-homocysteine => desmethylnectriapyrone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48841", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24573", "l": "[(1->4)-alpha-D-glucosyl](n) + sucrose => [(1->4)-alpha-D-glucosyl](n+1) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191763", "l": "snRNP:Snurportin complex formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199299", "l": "AKT phosphorylates FOXO transcription factors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940100", "l": "CDK1 phosphorylates VCPIP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26309", "l": "1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.28", "l": "\"1,4-dihydroxy-2-naphthoyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102460", "l": "kaempferol 3-gentiobioside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol-3-gentiobioside + UDP-L-rhamnose = H+ + kaempferol-3-O-gentiobioside-7-O-rhamnoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419049", "l": "ROCK activation by RHO (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080014", "l": "thalianol hydroxylase activity", "d": ["Catalysis of the reaction: a thalianol = a thalian-diol. This reaction is the addition of a hydroxyl group to thalianol ((13R,14R,17E)-podioda-8,17,21-trien-3beta-ol) to create a thalian-diol ((13R,14R,17E)-podioda-8,17,21-trien-3beta,X-diol), where the hydroxyl group may be attached at one of several different available carbons in ring B or C of thalianol, indicated by the X."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65517", "l": "5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O => NH4(+) + pre-mycofactocin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657791", "l": "miR-144 binds to the 3'UTR of the ABCA1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937034", "l": "IRAK1 phosphorylates Pellino (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44511", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354066", "l": "Translocation of PTK2 to Focal complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69803", "l": "ATP + benzoate + H(+) = benzoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71089", "l": "17beta-estradiol 3-sulfate(in) + 2 Na(+)(in) => 17beta-estradiol 3-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018805", "l": "benzylsuccinate synthase activity", "d": ["Catalysis of the reaction: fumarate + toluene = 2-benzylsuccinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31114", "l": "acetyl-CoA + butanoyl-CoA <=> 3-oxohexanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60045", "l": "beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose => alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3134914", "l": "Beta-catenin migrates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22363", "l": "D-glutamate <=> 5-oxo-D-proline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73299", "l": "(S)-malate(out) + H(+)(in) + phosphate(in) = (S)-malate(in) + H(+)(out) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850777", "l": "SPINK6 binds KLK14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21220", "l": "L-dopa + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": []}, {"i": "EC:1.13.11.29", "l": "\"stizolobate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52085", "l": "13-octadecanoyloxy-octadecanoate + H2O => 13-hydroxy-octadecanoate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672172", "l": "PI3-kinase binds to mutant PDGFR receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17717", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65864", "l": "5alpha-androst-1-ene-3,17-dione + A + H2O = 5alpha-androstan-1,3,17-trione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31355", "l": "dimethyl sulfide + H(+) + NADH + O2 = formaldehyde + H2O + methanethiol + NAD(+)", "d": []}, {"i": "EC:1.14.13.131", "l": "\"dissimilatory dimethyl-sulfide monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63179", "l": "(2S)-ibuprofenoyl-CoA <=> (2R)-ibuprofenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61661", "l": "(2E)-geraniol + ATP => (2E)-geranyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15779", "l": "1-guanidino-1-deoxy-scyllo-inositol + phosphate => 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34785", "l": "a 3-oxosteroid + H(+) + NADPH => a 3alpha-hydroxysteroid + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730882", "l": "Phosphorylation of PKC-theta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34345", "l": "4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone => (20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38661", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58186", "l": "(14E,18E)-lycopadiene + 2 diphosphate + NADP(+) => H(+) + NADPH + 2 phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15097", "l": "5-formimidoyltetrahydrofolate + L-glutamate = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31748", "l": "3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) => 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31707", "l": "2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18930", "l": "AH2 + O2 + thiophene-2-carbonyl-CoA => 5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444523", "l": "CXCR5 binds CXCL13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55027", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69508", "l": "H2O + N-acetyl-D-glucosamino-1,5-lactone = H(+) + N-acetyl-D-glucosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67539", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944454", "l": "mTORC1 phosphorylates MAF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106149", "l": "indole-3-carbonyl nitrile 4-hydroxylase activity", "d": ["Catalysis of the reaction: indole-3-carbonyl nitrile + NADPH +O2=4-hydroxyindole-3- carbonyl nitrile + NADP+ + H20."]}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0043176", "l": "amine binding", "d": ["Binding to an amine, a weakly basic organic compound that contains an amino or a substituted amino group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33580", "l": "NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate => H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10527", "l": "2-oxoglutarate + H(+) <=> CO2 + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382096", "l": "Formation of NR-NCOR Corepressor Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60210", "l": "3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate => 3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201611", "l": "Caspase-mediated cleavage of Rock-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31839", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-glucose", "d": []}, {"i": "EC:5.3.2.4", "l": "\"TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34180", "l": "H2O + mycophenolic acid O-acyl-beta-D-glucuronide => D-glucuronate + H(+) + mycophenolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46643", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH <=> 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39553", "l": "(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+) => (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31466", "l": "crocetin + UDP-alpha-D-glucose <=> beta-D-glucosyl crocetin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34937", "l": "diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => 2 ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446364", "l": "Migfilin interacts with VASP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9733292", "l": "AMY1-3 bind pramlintide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61149", "l": "myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose => H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62078", "l": "6-phospho-D-galactono-1,5-lactone + H(+) + NADH => D-galactose 6-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44373", "l": "Cr(6+) + 2 NADH + O2 => Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449829", "l": "IL11 binds IL11RA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990609", "l": "glutamate-cysteine ligase regulator activity", "d": ["Binds to and modulates the activity of glutamate-cysteine ligase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52179", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74396", "l": "2 (S)-lactate(in) + prostaglandin E1(out) => 2 (S)-lactate(out) + prostaglandin E1(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110442", "l": "Activated DINR binds Chico (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49621", "l": "D-erythritol 1-phosphate + NADP(+) => D-erythrulose 1-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008108", "l": "UDP-glucose:hexose-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12438", "l": "CoA + H(+) + N-caffeoylputrescine => (E)-caffeoyl-CoA + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15337", "l": "H2O + phenylglyoxylyl-CoA = CoA + H(+) + phenylglyoxylate", "d": []}, {"i": "EC:3.1.2.25", "l": "\"phenylacetyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684169", "l": "G6B binds PTPN6,PTPN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56529", "l": "chloride + D-tryptophan + FADH2 + O2 => 6-chloro-D-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36747", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.303", "l": "\"UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,3-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070909", "l": "glutamate:gamma-aminobutyric acid antiporter activity", "d": ["Catalysis of the reaction: glutamate(out) + gamma-aminobutyric acid(in) = glutamate(in) + gamma-aminobutyric acid(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24379", "l": "apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462041", "l": "HNP1-4 are released into phagocytic vacuoles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5622134", "l": "CRABP1 binds atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73489", "l": "a carboxylate(out) + orotate(in) => a carboxylate(in) + orotate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874078", "l": "PTK2 autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29246", "l": "H(+) + menaquinone-8 + NADH <=> menaquinol-8 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592371", "l": "Initial activation of proMMP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73889", "l": "chloride(in) + Na(+)(in) => chloride(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13303", "l": "a 1-acyl-sn-glycerol + a sterol ester => a 1,2-diacyl-sn-glycerol + a sterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10071", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose <=> 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29377", "l": "adenosine + phosphate => AMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71512", "l": "phylloquinone(out) => phylloquinone(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55583", "l": "ATP + H2O + L-glutamine <=> AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022856", "l": "protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbitol(out) = protein histidine + sorbitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182988", "l": "Sprouty lures CBL away from EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74734", "l": "Re-integration of insulin receptor into plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73969", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + octadecanoate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106343", "l": "glutarate dioxygenase activity", "d": ["Catalysis of the reaction glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19359", "l": "formaldehyde + H2O + N-methyl-L-proline + NADP(+) => H(+) + L-proline betaine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033770", "l": "2-hydroxyisoflavanone synthase activity", "d": ["Catalysis of the reactions: liquiritigenin + O2 + [reduced NADPH--hemoprotein reductase] = 2,4',7-trihydroxyisoflavanone + H2O + [oxidized NADPH--hemoprotein reductase] and (2S)-naringenin + O2 + [reduced NADPH--hemoprotein reductase] = 2,4',5,7-tetrahydroxyisoflavanone + H2O + [oxidized NADPH--hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373074", "l": "Receptor CCR9  binds CCL25 ligand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21738", "l": "(3S,5S)-3,5-diaminohexanoate => (3S)-3,6-diaminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030742", "l": "GTP-dependent protein binding", "d": ["Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74094", "l": "ATP + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) <=> ADP + H(+) + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51300", "l": "(9Z)-octadecenoate + L-phenylalanine = H2O + N-(9Z-octadecenoyl)-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851436", "l": "CFHR dimers bind C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21473", "l": "ATP + citrate + CoA => (3S)-citryl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39071", "l": "dodecanedioyl-CoA + O2 = (2E)-dodecenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41744", "l": "3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol = a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50742", "l": "glycine + leukotriene F4 => H2O + leukotriene C4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25153", "l": "2-oxoglutarate + L-phenylalanine => 3-phenylpyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149454", "l": "Packaging of HIV virion on the host cell plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678925", "l": "NR3C1 binds NR3C1 agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40262", "l": "(2E)-hexadecenedioyl-CoA + H2O <=> (3S)-hydroxyhexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20398", "l": "L-cysteine + O-succinyl-L-homoserine => H(+) + L,L-cystathionine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807565", "l": "GNLY is transferred to the phagosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47310", "l": "6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4167511", "l": "HLCS biotinylates ACACB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18247", "l": "ADP + CoA + H(+) => 3'-dephospho-CoA + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60395", "l": "Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O <=> Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29112", "l": "H(+) + NADPH + ubiquinone-8 => NADP(+) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004557", "l": "alpha-galactosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73584", "l": "CTP(out) + UDP(in) => CTP(in) + UDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70694", "l": "chloride(out) + glycine(out) + 2 Na(+)(out) <=> chloride(in) + glycine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696457", "l": "BDH2 dehydrogenates 3HBA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17429", "l": "NAD(+) + trans-4-hydroxycyclohexanecarboxylate = 4-oxocyclohexanecarboxylate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.226", "l": "\"4-hydroxycyclohexanecarboxylate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69585", "l": "GMP + inosine => guanosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31891", "l": "2-hydroxy-1-phenyl-1-propanone + NADP(+) = 1-phenyl-1,2-propanedione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047332", "l": "diphosphate-serine phosphotransferase activity", "d": ["Catalysis of the reaction: L-serine + diphosphate = O-phospho-L-serine + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625465", "l": "E2-mediated FOS gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57577", "l": "7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047440", "l": "2-dehydro-3-deoxy-D-pentonate aldolase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33496", "l": "all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate => 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60297", "l": "L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662610", "l": "MT1B binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35610", "l": "acetoin + NADP(+) <=> diacetyl + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36017", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54860", "l": "(2E)-geranial + H(+) + NADPH + O2 = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19173", "l": "H(+) + NADH + naphthalene + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)", "d": []}, {"i": "EC:1.14.12.12", "l": "\"naphthalene 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25406", "l": "(R)-3-hydroxy-3-methyl-2-oxopentanoate => (S)-2-ethyl-2-hydroxy-3-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38634", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73438", "l": "apigenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + ladanein + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23736", "l": "5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)", "d": []}, {"i": "EC:3.5.2.17", "l": "\"hydroxyisourate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13362", "l": "CTP + H(+) + sn-glycerol 3-phosphate => CDP-glycerol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0060175", "l": "brain-derived neurotrophic factor receptor activity", "d": ["Combining with a brain-derived neurotrophic factor and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192051", "l": "CYP7A1 7-hydroxylates CHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769394", "l": "AKT phosphorylates CBY1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27701", "l": "GDP-beta-L-galactose + phosphate <=> beta-L-galactose 1-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592231", "l": "Expression of CYCS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3296244", "l": "SUCNR1 binds SUCCA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12328", "l": "[(1->3)-alpha-D-glucosyl](n) + phosphate = [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate", "d": []}, {"i": "EC:2.4.1.334", "l": "\"1,3-alpha-oligoglucan phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015158", "l": "raffinose transmembrane transporter activity", "d": ["Enables the transfer of raffinose from one side of a membrane to the other. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013110", "l": "RHOC binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373717", "l": "DCC interacts with DIP13alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74906", "l": "(2E)-2-butenoate + ATP + H(+) <=> (2E)-but-2-enoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047901", "l": "formyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: formyl-CoA + H2O = CoA + formate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15505", "l": "(S)-2-hydroxymethylglutarate + NAD(+) = 2-formylglutarate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.291", "l": "\"2-hydroxymethylglutarate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10337", "l": "citrate => D-threo-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59731", "l": "(2R)-ethylmalonyl-CoA <=> (2S)-ethylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9709109", "l": "DHFR dimer binds DHFR inhibitors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44695", "l": "a fatty acyl-CoA + hexadecasphinganine <=> CoA + H(+) + N-acylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050370", "l": "tyrosine N-monooxygenase activity", "d": ["Catalysis of the reaction: tyrosine + O2 + NADPH + H+ = N-hydroxytyrosine + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49277", "l": "CTP + phytyl phosphate => CDP + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64542", "l": "a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5688797", "l": "ATXN3 family cleave Ub chains (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17785", "l": "H(+) + L-glutamate = 4-aminobutanoate + CO2", "d": []}, {"i": "EC:4.1.1.15", "l": "\"glutamate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442749", "l": "CaMKK autophosphorylates in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606564", "l": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31346", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O <=> (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42878", "l": "H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0004112", "l": "cyclic-nucleotide phosphodiesterase activity", "d": ["Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37716", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0015140", "l": "malate transmembrane transporter activity", "d": ["Enables the transfer of malate from one side of a membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33060", "l": "(R)-dihydrolipoamide + NAD(+) => (R)-lipoamide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63560", "l": "angiotensin I + H2O = angiotensin II + L-histidyl-L-leucine", "d": []}, {"i": "EC:3.4.15.1", "l": "\"peptidyl-dipeptidase A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71098", "l": "2 Na(+)(out) + pregnenolone sulfate(out) <=> 2 Na(+)(in) + pregnenolone sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928576", "l": "RHOA:GTP binds ROCK, activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22636", "l": "dCTP + H2O = dCMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198733", "l": "ERK5 is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59125", "l": "(S)-2,3-diaminopropanoate + ATP + citrate => 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112042", "l": "Opioid binds MOR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45469", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl diphosphate => (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50978", "l": "prostaglandin D2(in) => prostaglandin D2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70618", "l": "hexadecanoyl-[ACP] + L-lysyl-[protein] <=> H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62019", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983138", "l": "Transport of MHC heterotrimer to ER exit site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202604", "l": "Formation of a heteromeric BMP receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2995334", "l": "COX15 transforms heme O to heme A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46699", "l": "a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine <=> an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5226979", "l": "ADD1:ADD2 binds DMTN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55127", "l": "(2E)-5-methylhexenoyl-[ACP] + H(+) + NADH <=> 5-methylhexanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47856", "l": "ganglioside GD1a (d18:1(4E)) + H2O = ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16396", "l": "H2O + juvenile hormone II <=> H(+) + juvenile hormone II carboxylate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75997", "l": "3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out) => 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29983", "l": "cytidine(in) + H(+)(in) = cytidine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797962", "l": "DMGLY translocates from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250264", "l": "TXNIP binds reduced thioredoxin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15535", "l": "3-sulfopyruvate + H(+) + NADH => (2R)-3-sulfolactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63955", "l": "a sphingoid 1-phosphate + H2O <=> a sphingoid base + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770141", "l": "Formation of the Spliceosomal C* complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.6", "l": "\"CC-preferring endodeoxyribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42998", "l": "(R)-cembrene A + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634850", "l": "NPAS4 binds ARNT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40069", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + H(+) => 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607722", "l": "Active NIK phosphorylates IKKA dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32780", "l": "ATP + Co(2+)(out) + H2O => ADP + Co(2+)(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106418", "l": "UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase activity", "d": ["Catalysis of the reaction: ATP + UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786114", "l": "IL13:IL13RA:TYK2 binds IL4R:JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034480", "l": "phosphatidylcholine phospholipase C activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H+ + phosphocholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20153", "l": "ATP + L-arabinose = ADP + beta-L-arabinose 1-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.46", "l": "\"L-arabinokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49999", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865711", "l": "RAG1:RAG2 recombinase binds immunoglobulin kappa locus in a BRWD1-dependent manner (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63143", "l": "H2O + N-tetracosanoyl-taurine <=> taurine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73067", "l": "an N(4)-(oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O = an oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein]", "d": []}, {"i": "EC:3.2.1.96", "l": "\"mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9754964", "l": "ADA deamidates RBV (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19646", "l": "a D-threo-aldose + NAD(+) => a D-threo-aldono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74312", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66971", "l": "alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28728", "l": "Cu(2+)(in) + H(+)(in) => Cu(2+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55101", "l": "3-oxopentanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxypentanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61800", "l": "ATP + holo-[peptidyl-carrier protein] + L-alanine = AMP + diphosphate + L-alanyl-[peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.67", "l": "\"L-alanine--[L-alanyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671850", "l": "JAK2 Phosphoryates STAT3 in Response to Leptin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549322", "l": "OCT1 transports organic cations out of hepatic cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60689", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NAD(+) => (11R)-dihydroartemisinate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32735", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10151", "l": "blasticidin S + H(+) + H2O <=> deaminohydroxyblasticidin S + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647632", "l": "CASP3 cleaves GSDME (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54254", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74700", "l": "(5R)-hydroxy-beta-trans-bergamotene + O2 => (3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172433", "l": "Collagen type XIX degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004897", "l": "ciliary neurotrophic factor receptor activity", "d": ["Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35905", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA => 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47129", "l": "ATP + CoA + deoxycholate => AMP + deoxycholoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19577", "l": "luteolin + UDP-alpha-D-glucose = H(+) + luteolin 7-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22848", "l": "(3S)-hydroxyoctanedioyl-CoA + NAD(+) = 3-oxooctanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53155", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018551", "l": "dissimilatory sulfite reductase activity", "d": ["Catalysis of the reactions: [DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [DsrC protein]-dithiol + 2 AH2 + H+ + sulfite and [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O = [DsrC protein]-disulfide + 3 AH2 + 2 H+ + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202703", "l": "CD47 binds SIRP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73847", "l": "17alpha-hydroxywithaferin A + UDP-alpha-D-glucose = 17alpha-sitoindoside IX + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53891", "l": "D-glucose 6-phosphate + TDP-alpha-D-glucose <=> alpha,alpha-trehalose 6-phosphate + H(+) + TDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396009", "l": "STING binds c-di-GMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5633460", "l": "MDM2 binds TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50158", "l": "N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13504", "l": "ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] <=> ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58610", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-decanoylglycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388809", "l": "CTLA-4 binds B7-1/B7-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010180", "l": "thioglucosidase binding", "d": ["Binding to a thioglucosidase enzyme."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050645", "l": "limonoid glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + limonin = glucosyl-limonin + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23234", "l": "4 Fe(II)-[cytochrome c] + 4 H(+) + N2 => 4 Fe(III)-[cytochrome c] + hydrazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55670", "l": "11-cis-retinal--[retinol-binding protein] + H(+) + NADH => 11-cis-retinol--[retinol-binding protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38966", "l": "ATP + H2O + leukotriene C4(in) <=> ADP + H(+) + leukotriene C4(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29512", "l": "(2E,6E)-farnesyl diphosphate => (+)-valencene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13027", "l": "3-methyl-(2E)-glutaconyl-CoA + N(6)-biotinyl-L-lysyl-[protein] => 3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4093331", "l": "Ras:GTP binds p120-RasGAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015111", "l": "iodide transmembrane transporter activity", "d": ["Enables the transfer of iodide ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201608", "l": "Caspase-mediated cleavage of alpha adducin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29267", "l": "L-valine(in) + Na(+)(in) = L-valine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58231", "l": "L-asparaginyl-[protein] + NAD(+) <=> H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71288", "l": "chloride(out) + L-arginine(out) + 2 Na(+)(out) => chloride(in) + L-arginine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018798", "l": "RHOV binds GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10426", "l": "benzoate + glycine => H2O + N-benzoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030270", "l": "formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity", "d": ["Catalysis of the reaction: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran + H+ = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445064", "l": "Activation of Rac1 by VAV2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75937", "l": "6-O-phospho-N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine + ADP + H(+) => ATP + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0061799", "l": "cyclic pyranopterin monophosphate synthase activity", "d": ["Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0120241", "l": "2-iminobutanoate/2-iminopropanoate deaminase", "d": ["Catalyzes the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19 and EC 4.3.1.17."]}, {"i": "EC:3.5.99.10", "l": "\"2-iminobutanoate/2-iminopropanoate deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351913", "l": "Caspase-mediated cleavage of TJP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75870", "l": "5,6,7,8-tetrahydromethanopterin + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] <=> 5-methyl-5,6,7,8-tetrahydromethanopterin + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44919", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH <=> (3E)-decenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42141", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-(4R)-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173705", "l": "C5b binds C6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62075", "l": "D-galactose 6-phosphate + NADP(+) <=> 6-phospho-D-galactono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44425", "l": "a fatty acyl-CoA + heptadecasphing-4-enine => CoA + H(+) + N-acyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49602", "l": "AMP + diphosphate + octanedioyl-CoA => ATP + CoA + octanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944215", "l": "Association of procollagen type XX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52168", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51777", "l": "4-prenylphlorisobutanophenone + dimethylallyl diphosphate => deoxycohumulone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466392", "l": "NRF1:p-PPARGC1A, NRF2 bind the TFB2M promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380586", "l": "loading of Serotonin in synaptic vesicles (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30907", "l": "(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) = 2-methylbutanoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666008", "l": "SCAI binds SRF:MKL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67641", "l": "ATP + dZMP => ADP + dZDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295599", "l": "SPRY2 translocates to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044750", "l": "high-affinity nickel cation transmembrane transporter activity", "d": ["Catalysis of the high-affinity transfer of nickel (Ni) cations from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15964", "l": "4-hydroxymandelonitrile + UDP-alpha-D-glucose <=> H(+) + taxiphyllin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39880", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol => a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57700", "l": "a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23991", "l": "(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate <=> (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034018", "l": "ascopyrone tautomerase activity", "d": ["Catalysis of the reaction: 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 1,5-anhydro-4-deoxy-D-glycero-hex-1-en-3-ulose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080146", "l": "L-cysteine desulfhydrase activity", "d": ["Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434836", "l": "Syk/Lck phosphorylate LAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74091", "l": "ATP + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) = ADP + H(+) + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38667", "l": "sphing-4-enine 1-phosphate(in) = sphing-4-enine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031889", "l": "urotensin receptor binding", "d": ["Binding to a urotensin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203979", "l": "Coat Assembly (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20011", "l": "H(+) + linamarin + UDP => 2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69249", "l": "H2O + sinigrin => (Z)-N-(sulfonatooxy)prop-2-enimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48213", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983153", "l": "E1 mediated ubiquitin activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165179", "l": "Formation of TSC1:TSC2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49290", "l": "(R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+) => (R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60516", "l": "L-tryptophan = D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672980", "l": "Dissociation of RAS:RAF complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18571", "l": "an aromatic carboxylate + H(+) + H2O2 => an aromatic aldehyde + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40993", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA => (E)-4-coumaroyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047070", "l": "3-carboxyethylcatechol 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: O2 + 3-(2,3-dihydroxyphenyl)propanoate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73678", "l": "ADP(out) + dAMP(in) + H(+)(out) <=> ADP(in) + dAMP(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70373", "l": "CoA + H(+) + N-decanoyl-3-oxosphinganine => 3-oxosphinganine + decanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654511", "l": "FGFRL1 dimer binds FGFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847537", "l": "RAB43:GTP binds USP8NL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114354", "l": "SMAC binds XIAP:Caspase-7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190520", "l": "Association of Golgi  transport vesicles with microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1878002", "l": "XYLTs transfer Xyl to core protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28554", "l": "D-mannose 6-phosphate + H2O = D-mannose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10338", "l": "D-threo-isocitrate => citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14731", "l": "D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.53", "l": "\"3alpha(or 20beta)-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-378975", "l": "Follitropin is a heterodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68142", "l": "(2R,5R)-hexanediol + 2 NADP(+) => 2,5-hexanedione + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73919", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + H(+) = H2O + norlichexanthone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781897", "l": "USP11 deubiquitinates NFKBIA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62749", "l": "H2O + lovastatin => (S)-2-methylbutanoate + H(+) + monacolin J", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592240", "l": "Formation of NRF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200396", "l": "Creatine transport across the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187828", "l": "Translocation of p21 to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33296", "l": "L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23682", "l": "a ribonucleoside 5'-diphosphate + H(+) + phosphate => a ribonucleoside 5'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73412", "l": "succinate(in) + sulfate(out) => succinate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024630", "l": "Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0047577", "l": "4-hydroxybutyrate dehydrogenase activity", "d": ["Catalysis of the reaction: 4-hydroxybutanoate + NAD+ = H+ + NADH + succinate semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65711", "l": "alpha-D-mannose 1-phosphate + GDP-beta-L-galactose <=> beta-L-galactose 1-phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77094", "l": "Formation of cap binding complex (CBC) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45809", "l": "galactarate => (2S,3R)-dihydroxy-5-oxohexanedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10321", "l": "trans-3-hydroxy-L-proline => 1-pyrroline-2-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0050815", "l": "phosphoserine residue binding", "d": ["Binding to a phosphorylated serine residue within a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351901", "l": "Caspase-mediated cleavage of MST3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15536", "l": "(2R)-3-sulfolactate + NAD(+) <=> 3-sulfopyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2545196", "l": "FN1 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0036355", "l": "2-iminoacetate synthase activity", "d": ["Catalysis of the reaction: L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28669", "l": "(S)-propane-1,2-diol + NAD(+) => H(+) + hydroxyacetone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948757", "l": "AKT phosphorylates MKRN1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67944", "l": "2-hydroxyhexadecanoate + O2 = 2-oxohexadecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36511", "l": "(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54323", "l": "a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0035758", "l": "chemokine (C-C motif) ligand 21 binding", "d": ["Binding to chemokine (C-C motif) ligand 21."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72631", "l": "Formation of the cap-binding eIF4F complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66691", "l": "4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2 <=> (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31701", "l": "3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al => 4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75134", "l": "neomorphinone <=> morphinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694436", "l": "nsp15 forms a hexamer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102357", "l": "mithramycin dehydrogenase activity", "d": ["Catalysis of the reaction: mithramycin + NADP = mithramycin DK + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9750942", "l": "USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11627", "l": "2-(hydroxyimino)propanoate + acetone <=> acetone oxime + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56296", "l": "2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein] = pyruvate + S-sulfanyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371527", "l": "HSF1 trimer translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682011", "l": "LC3 binds ATG7 dimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803063", "l": "RNASEs bind bacterial LPS, PGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72624", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxy-fatty acyl)-sphingoid base => a 1,2-diacyl-sn-glycerol + inositol-1-phospho-N-(2-hydroxy-fatty acyl)-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61893", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38416", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O => (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54143", "l": "cytidine(49) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54576", "l": "2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 = an adenosine in tRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62245", "l": "a cytidine(6-4)thymidine in DNA => a cytidine-thymine dinucleotide in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37648", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624120", "l": "CEBPA binds CDK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712201", "l": "GNAL exchanges GDP for GTP in odorant:Olfactory Receptor:GNAL:GDP:GNB1:GNG13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371590", "l": "HSP70 binds to HSP40:nascent protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55014", "l": "(3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+) => (1S,4R)-1-hydroxylimonen-2-one + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47582", "l": "ganglioside GT2 (d18:1(4E)) + H(+) + UDP => ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322429", "l": "XIAP monoubiquinates TLE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38492", "l": "2-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085318", "l": "SUMOylation of NCOA2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22891", "l": "(R)-methylmalonyl-CoA <=> succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848316", "l": "IL36 binds IL1RL2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11062", "l": "AMP + diphosphate + L-isoleucyl-tRNA(Ile) => ATP + L-isoleucine + tRNA(Ile)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37247", "l": "H2O + thymidine 3'-monophosphate = phosphate + thymidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788622", "l": "p-Y-STATs dimerize (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39732", "l": "3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64302", "l": "3-phenylpropanal + L-alanine => 3-phenylpropylamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28757", "l": "a ubiquinol + dihydroxyacetone phosphate => a ubiquinone + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14480", "l": "a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75867", "l": "5,6,7,8-tetrahydromethanopterin + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] = 5-methyl-5,6,7,8-tetrahydromethanopterin + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}, {"i": "EC:2.1.1.384", "l": "\"[methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]--tetrahydromethanopterin methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70360", "l": "3-oxosphinganine + a fatty acyl-CoA => CoA + H(+) + N-acyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72062", "l": "glycochenodeoxycholate(out) + 2 Na(+)(out) <=> glycochenodeoxycholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45947", "l": "12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72422", "l": "(E)-4-coumarate + ATP + H(+) <=> (E)-4-coumaroyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15302", "l": "D-apiitol + NAD(+) => aldehydo-D-apiose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373705", "l": "Caspase cleavage of DCC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200954", "l": "Nef Binds and activates the Src-family tyrosine kinase Lck (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879562", "l": "SLCO2B1 has a narrow substrate specificity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668714", "l": "RAC1:GTP binds NOX1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68748", "l": "alpha-D-glucose 1-phosphate + O-phospho-L-seryl-[protein] = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22686", "l": "(2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O => 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395412", "l": "Phosphorylation of SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.2.2", "l": "\"adenylosuccinate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201639", "l": "Caspase-mediated cleavage of GAS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74227", "l": "H2O + L-threonyl-tRNA(Ile) = L-threonine + tRNA(Ile)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432507", "l": "Cytosolic TIM is degraded by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10690", "l": "phosphate + streptomycin => H2O + streptomycin 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44529", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69427", "l": "2-hydroxyisobutanoyl-CoA <=> acetone + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981892", "l": "Active G alpha (z) binds RGS proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.357", "l": "\"3alpha-hydroxysteroid 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.10", "l": "\"bacterial leucyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800035", "l": "IGFBP3 binds TMEM219 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419861", "l": "Melanospin is stimulated by light (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61110", "l": "(2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466802", "l": "Defective ABCA4 does not transport NRPE from disc membranes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69309", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate => phenylacetonitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54966", "l": "hexadecanoyl phosphate + holo-[ACP] => hexadecanoyl-[ACP] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38722", "l": "(R)-carnitine(out) + ATP + H2O <=> (R)-carnitine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655351", "l": "Activated FGFR4 mutants bind FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782820", "l": "USP17 deubiquitinates SUDS3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014433", "l": "RHOG GEFs activate RHOG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19056", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O <=> H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955844", "l": "RBKS phosphorylates ribose to R5P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29443", "l": "H(+)(in) + L-alanine(in) = H(+)(out) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418845", "l": "Activation of caspase-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641205", "l": "RSPO:LGR binds ZNRF3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204798", "l": "Interaction of Tie2 and p85 of PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17086", "l": "4-pyridoxate + A => 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638006", "l": "ARL3 hydrolyzes GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.256", "l": "\"N-terminal methionine N(alpha)-acetyltransferase NatC\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41359", "l": "bacteriochlorophyll a + 3 NADP(+) <=> geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371467", "l": "SIRT1 deacetylates HSF1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050344", "l": "trans-cinnamate 2-monooxygenase activity", "d": ["Catalysis of the reaction: trans-cinnamate + H+ + NADPH + O2 = 2-coumarate + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0016597", "l": "amino acid binding", "d": ["Binding to an amino acid, organic acids containing one or more amino substituents."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10714", "l": "2-phenylacetamide + CO2 + H2O => L-phenylalanine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731924", "l": "EDNRA binds EDNs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39163", "l": "3-oxohexadecanoyl-CoA + H(+) + NADPH = (3R)-hydroxyhexadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:1902248", "l": "5-O-phosphono-alpha-D-ribofuranosyl diphosphate binding", "d": ["Binding to 5-O-phosphono-alpha-D-ribofuranosyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13833", "l": "L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine", "d": []}, {"i": "EC:2.6.1.84", "l": "\"arginine--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203712", "l": "eNOS associates with Caveolin-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67755", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022831", "l": "narrow pore, gated channel activity", "d": ["Enables the transport of a solute across a membrane via a narrow pore channel that opens in response to a particular stimulus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54294", "l": "3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate => ATP + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75079", "l": "24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 32-hydroxy-24,25-dihydrolanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193684", "l": "p62 recruits an atypical PKC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35584", "l": "2-dehydro-3-deoxy-D-gluconate => D-glyceraldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69833", "l": "6-deoxycathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => campestanol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088441", "l": "FOXM1 stimulates CENPF transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54421", "l": "3',3'-c-di-AMP + H2O => 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71697", "l": "2 H(+)(in) + L-alanyl-L-aspartate(in) => 2 H(+)(out) + L-alanyl-L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134821", "l": "DNA-PK binds microbial dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39085", "l": "acetyl-CoA + decanedioyl-CoA => 3-oxododecanedioyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68474", "l": "(E)-alpha-bisabolene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31217", "l": "(5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH => (5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047077", "l": "Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity", "d": ["Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201611", "l": "Caspase-mediated cleavage of Rock-1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391933", "l": "EP3 receptor can bind PGE2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58615", "l": "2 L-ascorbate + N-octanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33499", "l": "H(+) + prephenate = 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2", "d": []}, {"i": "EC:4.1.1.100", "l": "\"prephenate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848338", "l": "PNPLA4 hydrolyzes TAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32486", "l": "H(+) + H2O + pheophorbide a <=> CO2 + methanol + pyropheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59627", "l": "H2O + N(2)-(4-aminobutanoyl)-L-ornithine <=> 4-aminobutanoate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.8", "l": "\"hypoxanthine phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58080", "l": "1-docosanoylglycerol + H2O = docosanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043812", "l": "phosphatidylinositol-4-phosphate phosphatase activity", "d": ["Catalysis of the reaction: phosphatidyl-1D-myo-inositol-4-phosphate + H2O = phosphatidyl-1D-myo-inositol + phosphate."]}, {"i": "RHEA:55652", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70908", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate => (2R)-3-phosphoglycerate + alpha-D-mannose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17103", "l": "(R)-carnitine + a fatty acid + H(+) => H2O + O-acyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69000", "l": "3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine = 3-amino-2-hydroxy-4-methoxybenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.380", "l": "\"3-amino-4-hydroxybenzoate 4-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247497", "l": "ERBB3 binds neuregulins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036200", "l": "3-ketosteroid 9-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: androsta-1,4-diene-3,17-dione + NADH + H+ + O2 = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9659611", "l": "ANO1 inhibitors bind ANO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14289", "l": "a dicarboxylate + ATP + CoA = AMP + diphosphate + omega-dicarboxyl-CoA", "d": []}, {"i": "EC:6.2.1.23", "l": "\"dicarboxylate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111879", "l": "PIP2 hydrolysis (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380240", "l": "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25583", "l": "alpha-L-fucose <=> beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102238", "l": "geraniol kinase activity (ATP-dependent) activity", "d": ["Catalysis of the reaction: geraniol + ATP = geranyl monophosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11312", "l": "atrazine + H2O = chloride + H(+) + hydroxyatrazine", "d": []}, {"i": "EC:3.8.1.8", "l": "\"atrazine chlorohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694462", "l": "ABHD6,12 hydrolyse 3AG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102982", "l": "UDP-3-dehydro-alpha-D-glucose dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + NAD <=> H+ + UDP-3-keto-alpha-D-glucose + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621571", "l": "CD209 binds ICAM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24141", "l": "guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789092", "l": "NOX2 generates superoxide anion from oxygen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371518", "l": "SIRT1 binds to HSF1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29979", "l": "2'-deoxyadenosine(in) + H(+)(in) = 2'-deoxyadenosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395784", "l": "Nascent CMs transform into mature CMs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72302", "l": "3,3',5-triiodo-L-thyronine(out) + L-glutamate(in) <=> 3,3',5-triiodo-L-thyronine(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21916", "l": "an aliphatic amine + 2 Fe(III)-[cytochrome c550] + H2O = an aldehyde + 2 Fe(II)-[cytochrome c550] + 2 H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52970", "l": "H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP => hyocholate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65354", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O => 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28867", "l": "H(+)(in) + lactose(in) = H(+)(out) + lactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57847", "l": "fraxetin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950681", "l": "Expression of Lamin-B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25428", "l": "ATP + N-acetyl-D-hexosamine = ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18799", "l": "a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "58.382128244041638", "identifiers": [{"i": "GO:0004497", "l": "monooxygenase activity", "d": ["Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014812", "l": "ROBOs bind keratan sulfate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54069", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O => diphosphate + sesterfisherol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67418", "l": "(1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28909", "l": "3-(3-hydroxyphenyl)propanoate(out) + H(+)(out) => 3-(3-hydroxyphenyl)propanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102452", "l": "bisdemethoxycurcumin synthase activity", "d": ["Catalysis of the reaction: 2 4-coumaryl-CoA + malonyl-CoA + H2O + H+ <=> 3 coenzyme A + bisdemethoxycurcumin + 2 carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18594", "l": "sphinganine 1-phosphate => hexadecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63863", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (2R,9Z,12Z)-2-hydroperoxyoctadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018782", "l": "cis-chloroacrylic acid dehalogenase activity", "d": ["Catalysis of the reaction: cis-3-chloroacrylic acid + H2O = H+ + HCl + malonate semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44525", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66401", "l": "ATP + glutathione(in) + glycocholate(in) + H2O => ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21712", "l": "L-threo-3-phenylserine = benzaldehyde + glycine", "d": []}, {"i": "EC:4.1.2.26", "l": "\"phenylserine aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16499", "l": "H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine => adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333609", "l": "MeSebGalNac is hydrolysed to MeSeH and bGalNac (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16477", "l": "NAD(+) + prostaglandin E1 = 15-oxoprostaglandin E1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9724685", "l": "IgE binds omalizumab (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047791", "l": "cucurbitacin delta23-reductase activity", "d": ["Catalysis of the reaction: 23,24-dihydrocucurbitacin + NAD(P)+ = cucurbitacin + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682377", "l": "LC3 de-lipidation by ATG4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140320", "l": "PAMP receptor decoy activity", "d": ["Binding and sequestering PAMP ligands in order to prevent them from binding and activating to the host PAMP receptor. Usually this activity is encoded by a symbiont or a pathogen to prevent activation of the host innate immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24638", "l": "H(+) + NADH => H2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53199", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106078", "l": "histone succinyltransferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + histone = CoA + succinyl-histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191303", "l": "FDPS dimer transfers IPPP to GPP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38685", "l": "ADP + H(+) + phosphate + sphing-4-enine(out) => ATP + H2O + sphing-4-enine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876868", "l": "ECE1 cleaves EDN1(53-90) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001607", "l": "neuromedin U receptor activity", "d": ["Combining with neuromedin U to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008935", "l": "1,4-dihydroxy-2-naphthoyl-CoA synthase activity", "d": ["Catalysis of the reaction: 2-succinylbenzoyl-CoA + H+ = 1,4-dihydroxy-2-naphthoyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015187", "l": "glycine transmembrane transporter activity", "d": ["Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23635", "l": "D-threo-isocitrate + NAD(+) <=> 2-oxoglutarate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45757", "l": "(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8948136", "l": "ULK1 Translocates to the mitochondria (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010997", "l": "anaphase-promoting complex binding", "d": ["Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218822", "l": "CRK binds BCAR1 and or PXN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035651", "l": "AP-3 adaptor complex binding", "d": ["Binding to an AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16111", "l": "ADP + beta-D-fructose 1,6-bisphosphate + H(+) => ATP + beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683774", "l": "p-T68-CHEK2 dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6795473", "l": "PDPK1 phosphorylates SGK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010427", "l": "abscisic acid binding", "d": ["Binding to abscisic acid, a plant hormone that regulates aspects of plant growth."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990147", "l": "talin binding", "d": ["Binding to a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27902", "l": "caffeine + H2O + ubiquinone-0 = 1,3,7-trimethylurate + ubiquinol-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65695", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine <=> a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62900", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168950", "l": "TLR6:TLR2 is recruited to ligand:CD14:CD36 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018654", "l": "2-hydroxy-phenylacetate hydroxylase activity", "d": ["Catalysis of the reaction: 2-hydroxyphenylacetate + NADH + O2 = NAD+ + OH- + homogentisate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.15.1", "l": "\"venom exonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211904", "l": "CYP4F12 18-hydroxylates ARA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35035", "l": "4-aminobutanoate(in) = 4-aminobutanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25176", "l": "H2O + N(omega)-methyl-L-arginine <=> L-citrulline + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38942", "l": "dioscin + 2 H2O <=> diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55653", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63459", "l": "(2E,6E,10E)-geranylgeraniol + CTP <=> (2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11578", "l": "AMP + H(+) + thiamine diphosphate => ATP + thiamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632677", "l": "PTCH is internalized (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18490", "l": "cyanate + H(+) + hydrogencarbonate => carbamate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429157", "l": "ABCC4 accumulation of dense granule contents (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23799", "l": "17-O-acetylnorajmaline + H2O <=> acetate + H(+) + norajmaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72910", "l": "D-mannose(out) + Na(+)(out) <=> D-mannose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49535", "l": "4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O <=> ethylene glycol + H(+) + terephthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59909", "l": "H2O + hexanal + NADP(+) => 2 H(+) + hexanoate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166168", "l": "TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45856", "l": "3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44841", "l": "(R)-carnitine + octadecanoyl-CoA => CoA + O-octadecanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47019", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O <=> [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28750", "l": "NH4(+)(in) <=> NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31468", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose => bis(beta-D-glucosyl) crocetin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418845", "l": "Activation of caspase-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68857", "l": "(2Z,6E)-farnesyl diphosphate => (E)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110218", "l": "Cleavage of uracil by TDG glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0120227", "l": "acyl-CoA binding", "d": ["Binding to an acyl-CoA, a thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any carboxylic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59229", "l": "6-sulfo-alpha-D-quinovose => 6-sulfo-beta-D-quinovose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734730", "l": "ORC1 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73180", "l": "S-adenosyl-L-methionine + scutellarein => H(+) + S-adenosyl-L-homocysteine + scutellarein 4'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65871", "l": "Delta(1)-dihydrotestosterone + H2O <=> 1,17beta-dihydroxyandrostan-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030560", "l": "tRNA pseudouridylation guide activity", "d": ["Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3321805", "l": "NSL acetylates histone H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12573", "l": "(R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP => adenosylcob(III)inamide + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61697", "l": "ATP + glycine + holo-[peptidyl-carrier protein] => AMP + diphosphate + glycyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47357", "l": "an octanoate ester + H2O => an aliphatic alcohol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218836", "l": "PTK2beta binds alphaVbeta3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694433", "l": "MIA2 binds PREB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827994", "l": "SOX17 binds the PDPN gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29126", "l": "nitrate(out) + ubiquinol-8(in) <=> H2O(out) + nitrite(out) + ubiquinone-8(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38334", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10832", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "d": []}, {"i": "EC:3.1.4.50", "l": "\"glycosylphosphatidylinositol phospholipase D\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102576", "l": "3-oxo-palmitoyl-ACP hydrolase activity", "d": ["Catalysis of the reaction: H2O + a 3-oxo-palmitoyl-[acp] = 3-oxopalmitic acid + H+ + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21586", "l": "H(+) + hydroxyacetone phosphate + NADH => NAD(+) + propane-1,2-diol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611851", "l": "ADRB2 bind ADR,NAd (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54467", "l": "1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39904", "l": "isoxazolin-5-one + O-acetyl-L-serine => 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11130", "l": "2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA => 4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47561", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) => CMP + ganglioside GM1b (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21343", "l": "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 <=> 2 vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198714", "l": "ERK5 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72397", "l": "2 chloride(in) + K(+)(in) + Na(+)(in) => 2 chloride(out) + K(+)(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72804", "l": "L-arginine(out) + N(omega)-methyl-L-arginine(in) => L-arginine(in) + N(omega)-methyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19656", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) <=> CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0032028", "l": "myosin head/neck binding", "d": ["Binding to the head/neck region of a myosin heavy chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205244", "l": "Recruitment of CBL to KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689317", "l": "Formation of the pre-incision complex in GG-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46644", "l": "cortisol + H(+) + NADPH = 5beta-dihydrocortisol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805035", "l": "TP53 binds STK11 and NUAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28956", "l": "aldehydo-D-glucuronate(in) + H(+)(in) => aldehydo-D-glucuronate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46264", "l": "an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038387", "l": "Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54907", "l": "(2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH <=> (9Z)-hexadecenoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39048", "l": "26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35327", "l": "eicosanoyl-CoA + H(+) + malonyl-CoA = 3-oxodocosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19495", "l": "alpha-D-glucose 1-phosphate + D-glucose => D-cellobiose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25942", "l": "8-chloroquinolin-2(1H)-one + AH2 => 8-chloroquinoline + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913456", "l": "Interleukin-5 receptor alpha subunit binds Interleukin-5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140802", "l": "NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: [protein]-C-terminal glycine + NAD+ = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide."]}, {"i": "RHEA:58268", "l": "[protein]-C-terminal glycine + NAD(+) = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62906", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45200", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": []}, {"i": "EC:2.1.1.258", "l": "\"5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170964", "l": "FRS2 binds to active TrkA receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032775", "l": "YAP1 binds TEAD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690023", "l": "NUBPL binds 4Fe-4S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624112", "l": "CEBPA binds CDK4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186785", "l": "PDGF-AA clevage by Furin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609740", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3B (GRIN3B) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199404", "l": "CD40L binds CD40 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49303", "l": "D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] <=> alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14015", "l": "adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate => 3'-phosphoadenylyl sulfate + taurolithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665871", "l": "ADRM1 binds 26S proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54960", "l": "ATP + CoA + dinor-OPDA = AMP + dinor-OPDA-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52405", "l": "3-dehydro-4-O-phospho-L-erythronate + H(+) => CO2 + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388596", "l": "Melanocortin receptors bind melanocortins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16107", "l": "a (2E)-enoyl-CoA + H2O => a (3S)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975040", "l": "KRAB-ZNF / KAP Interaction (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55297", "l": "13-cis-retinol + hexadecanoyl-CoA => 13-cis-retinyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10560", "l": "4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O = 2,5-dioxopentanoate + NH4(+)", "d": []}, {"i": "EC:3.5.4.22", "l": "\"1-pyrroline-4-hydroxy-2-carboxylate deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64345", "l": "4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2 => 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65724", "l": "2-oxoglutarate + O2 + pentyl sulfate = CO2 + H(+) + pentanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31241", "l": "4 CO2 + coproporphyrinogen I => 4 H(+) + uroporphyrinogen I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55622", "l": "a carotenoid beta-end derivative => a carotenoid psi-end group", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45244", "l": "(3E,5Z)-octadienoyl-CoA = (2E,4E)-octadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49767", "l": "ethylenediaminetriacetate + FMNH2 + O2 <=> ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299359", "l": "Activation of TALK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222093", "l": "BRD7 binds TP53 and EP300 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74561", "l": "aldosterone hemiacetal => aldosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14286", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose => 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12453", "l": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53324", "l": "2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49076", "l": "dibenzothiophene + FMNH2 + O2 = dibenzothiophene 5-oxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13878", "l": "a 2-oxocarboxylate + L-ornithine => an L-alpha-amino acid + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102538", "l": "UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-quinovosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49839", "l": "(5E)-tetradecenoyl-CoA + (R)-carnitine <=> (5E)-tetradecenoyl-(R)-carnitine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34343", "l": "(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168638", "l": "Activated IKK phosphorylates I-kappaB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72665", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-phenylalanine => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-phenylalanyl-[tubulin] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37479", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42145", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443774", "l": "Trans-homodimerization of Neurofascin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61961", "l": "a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45822", "l": "2-methylfumaryl-CoA + succinate => mesaconate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987214", "l": "p-STAT3 dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051787", "l": "misfolded protein binding", "d": ["Binding to a misfolded protein."]}, {"i": "REACT:R-HSA-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010313", "l": "phytochrome binding", "d": ["Binding to a phytochrome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55397", "l": "(R)-carnitine + H(+) + NADH + O2 => (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211346", "l": "NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58986", "l": "acrylate + H(+) + H2O2 => acrolein + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52399", "l": "4-O-phospho-D-threonate + NAD(+) <=> CO2 + dihydroxyacetone phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805103", "l": "AURKA phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23251", "l": "myo-inositol + S-adenosyl-L-methionine <=> 1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29231", "l": "cyanate(in) = cyanate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70942", "l": "L-methionine(in) <=> L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624949", "l": "Assembly of the anterograde IFT train (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20097", "l": "D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O", "d": []}, {"i": "EC:4.2.1.8", "l": "\"mannonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43536", "l": "2 D-glyceraldehyde 3-phosphate = 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate", "d": []}, {"i": "EC:4.2.3.153", "l": "\"(5-formylfuran-3-yl)methyl phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943083", "l": "US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22690", "l": "H2O2 + NH4(+) + pyruvate => D-alanine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854052", "l": "Formation of the SCF-FBXL7 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10109", "l": "(7S)-salutaridinol + NADP(+) => H(+) + NADPH + salutaridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43377", "l": "5'-deoxyinosine + phosphate => 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351901", "l": "Caspase-mediated cleavage of MST3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12540", "l": "ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)", "d": []}, {"i": "EC:6.1.1.7", "l": "\"alanine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390593", "l": "ATP Hydrolysis By Myosin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59521", "l": "ATP + butanoyl-CoA + hydrogencarbonate => (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36478", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA <=> (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602484", "l": "Activation of proMMP11 by FURIN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2248891", "l": "Active ARSA translocates to the lysosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38622", "l": "nicotinate beta-D-ribonucleotide + phenol <=> H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390597", "l": "Release Of ADP From Myosin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59991", "l": "cyclohexane-1-carbonyl-CoA + NADP(+) <=> cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20908", "l": "3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.225", "l": "\"N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32458", "l": "(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69142", "l": "Recruitment of Dna2 endonuclease (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610735", "l": "NUMB binds ITCH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20255", "l": "dimethylmaleate + H2O => (2R,3S)-2,3-dimethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19058", "l": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione => a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684096", "l": "CDK2 phosphorylates RBBP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.13", "l": "\"RNA helicase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705584", "l": "HMGCR dimer binds statins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62600", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11815", "l": "H2O + methanethiol + O2 <=> formaldehyde + H(+) + H2O2 + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629004", "l": "Transport of MCP:pPR-AP:pAP Complex into the Nucleous (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734713", "l": "ORC6 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1028820", "l": "Formation of VAF (virus-activated factor) complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112609", "l": "POU5F1 (OCT4), SOX2, NANOG, ZSCAN10, PRDM14, SMAD2, FOXP1-ES bind the POU5F1 (OCT4) promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28908", "l": "3-(3-hydroxyphenyl)propanoate(in) + H(+)(in) => 3-(3-hydroxyphenyl)propanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847544", "l": "The COG complex and CUX1 and GOLGA5 dimers contribute to intra-Golgi vesicle tethering (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848776", "l": "PTK6 phosphorylates DOK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55369", "l": "(R)-carnitine + H(+) + NADPH + O2 => (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27625", "l": "geranylgeranyl diphosphate + 7 isopentenyl diphosphate <=> 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30017", "l": "alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17496", "l": "A + glycerol <=> AH2 + dihydroxyacetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52798", "l": "Ni(2+) + sirohydrochlorin => 2 H(+) + Ni-sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74389", "l": "formamide(in) => formamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42775", "l": "guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990955", "l": "G-rich single-stranded DNA binding", "d": ["Binding to G-rich, single-stranded DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448958", "l": "Nuclear translocation of p38 MAPK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869683", "l": "oxPL binds LBP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49806", "l": "FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine => 2-methylpropan-1-amine + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.706056554619465", "identifiers": [{"i": "GO:0043021", "l": "ribonucleoprotein complex binding", "d": ["Binding to a complex of RNA and protein."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0001671", "l": "ATPase activator activity", "d": ["Binds to and increases the activity of an ATP hydrolysis activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.6", "l": "\"lysine/arginine leucyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62210", "l": "3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15941", "l": "H2O + N(2)-acetyl-L-ornithine = acetate + L-ornithine", "d": []}, {"i": "EC:3.5.1.16", "l": "\"acetylornithine deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9724745", "l": "PLG(20-810) binds aprotinin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74716", "l": "Insulin binds the insulin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036308", "l": "16S rRNA (guanine(1516)-N(2))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1516) in 16S rRNA = N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186780", "l": "PI3-kinase binds to the active receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17599", "l": "D-fructose + 2 Fe(II)-[cytochrome c] + 2 H(+) => D-mannitol + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72090", "l": "2 Na(+)(out) + taurodeoxycholate(out) <=> 2 Na(+)(in) + taurodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67491", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004589", "l": "dihydroorotate dehydrogenase (NADH) activity", "d": ["Catalysis of the reaction: (S)-dihydroorotate + NAD+ = H+ + NADH + orotate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388503", "l": "Oxytocin receptor bind oxytocin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13748", "l": "ascopyrone M <=> microthecin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416690", "l": "SEMA4A binds to PLXND1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30523", "l": "GTP + L-glutamate + oxidized coenzyme F420-1 = GDP + H(+) + oxidized coenzyme F420-2 + phosphate", "d": []}, {"i": "EC:6.3.2.34", "l": "\"coenzyme F420-1:gamma-L-glutamate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.15.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48518", "l": "dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) => 1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58879", "l": "4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419334", "l": "Melatonin receptors can bind melatonin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109860", "l": "MAP2K1 phosphorylates MAPK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604731", "l": "Autocatalytic activation of MMP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0034039", "l": "8-oxo-7,8-dihydroguanine DNA N-glycosylase activity", "d": ["Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218821", "l": "PDK1 phosphorylates PKC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20847", "l": "ATP + hydrogencarbonate + pyruvate <=> ADP + H(+) + oxaloacetate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53163", "l": "H2O + N-acyl-sn-glycero-3-phosphoethanolamine <=> an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63540", "l": "H2O + neurotensin = L-leucine + neurotensin-(1-12)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27654", "l": "2-oxobutanoate + H(+) + pyruvate = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15481", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine", "d": []}, {"i": "EC:2.1.2.1", "l": "\"glycine hydroxymethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72898", "l": "2 acetyl-CoA + 3 H(+) + 6 malonyl-CoA + 2 S-adenosyl-L-methionine <=> 4-O-demethylbarbatate + 6 CO2 + 8 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32951", "l": "sucrose = trehalulose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018736", "l": "6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA + H2O = 3-hydroxypimeloyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-178208", "l": "SMAD7 binds to SMURF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29366", "l": "dCMP + H2O <=> 2'-deoxycytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.111", "l": "\"1,3-alpha-L-fucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769394", "l": "AKT phosphorylates CBY1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47269", "l": "bacterioruberin => H2O + monoanhydrobacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070628", "l": "proteasome binding", "d": ["Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38654", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.39", "l": "\"4-hydroxybenzoate polyprenyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937369", "l": "ATAD2 binds ESR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68921", "l": "ATP + H(+) + NADPH + pentanoate => AMP + diphosphate + NADP(+) + pentanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59903", "l": "2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 <=> CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48918", "l": "CMP + ganglioside GD1c + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192051", "l": "CYP7A1 7-hydroxylates CHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1011598", "l": "DOCKs bind to RhoGEFs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57893", "l": "a quinone + 5 H(+)(in) + NADPH => a quinol + 4 H(+)(out) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69868", "l": "a uridine in RNA + S-adenosyl-L-methionine => a 5-methyluridine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.7", "l": "\"asclepain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042014", "l": "interleukin-19 receptor activity", "d": ["Combining with interleukin-19 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004925", "l": "prolactin receptor activity", "d": ["Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5691167", "l": "CUL1, SKP1, FBXL5 bind (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106231", "l": "protein-propionyllysine depropionylase activity", "d": ["Catalysis of the reaction:H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD+ = 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:23500", "l": "H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) = 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24053", "l": "a ubiquinone + reduced [electron-transfer flavoprotein] => a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14080", "l": "3-oxopropanoate + L-alanine <=> beta-alanine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990827", "l": "deaminase binding", "d": ["Binding to an enzyme that catalyzes the removal of an amino group from a substrate, producing ammonia (NH3)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71776", "l": "acetoacetate(out) + H(+)(out) => acetoacetate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102229", "l": "amylopectin maltohydrolase activity", "d": ["Catalysis of the reaction: n H2O + an exposed unphosphorylated, unbranched malto-oligosaccharide tail on amylopectin <=> amylopectin + maltose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18352", "l": "ATP + L-aspartate + tRNA(Asx) <=> AMP + diphosphate + L-aspartyl-tRNA(Asx)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14044", "l": "(R)-vicianin + H2O <=> mandelonitrile + vicianose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69117", "l": "glyoxylate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195378", "l": "Homodimerization of VEGF proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426489", "l": "RISC binds inexactly matching target RNAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48531", "l": "ganglioside GP1c (d18:1(4E)) + H2O <=> ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5213464", "l": "RIPK1 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10388", "l": "GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75279", "l": "an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9612509", "l": "SGK phosphorylates SRF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25567", "l": "H2O + N-acetyl-4-O-acetylneuraminate <=> acetate + H(+) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24196", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) = (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685608", "l": "CLEC2B binds KLRF1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.137", "l": "\"2-acyl-4-prenylphloroglucinol 6-prenyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37711", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141439", "l": "Release of activated MAD2 from kinetochores (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5622134", "l": "CRABP1 binds atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58092", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38043", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.11", "l": "\"acyl-[acyl-carrier-protein] 4-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961982", "l": "RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50733", "l": "4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] => (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25636", "l": "laricitrin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + syringetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17201", "l": "2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H2O", "d": []}, {"i": "EC:4.2.1.43", "l": "\"2-dehydro-3-deoxy-L-arabinonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009282", "l": "CDK1 phosphorylates RUNX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709098", "l": "DHFR dimer reduces FOLA to DHF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72096", "l": "(S)-carnitine(out) + Na(+)(out) => (S)-carnitine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73806", "l": "AIR + CO2 => CAIR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50541", "l": "prostaglandin A2 => prostaglandin C2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19248", "l": "N-phenylhydroxylamine <=> 2-aminophenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42890", "l": "(R)-3,5-bisphosphomevalonate + ADP + H(+) => (R)-3-phosphomevalonate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46594", "l": "calcitriol + H2O + 2 oxidized [adrenodoxin] => alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50953", "l": "7-chloro-L-tryptophan + AH2 + O2 => A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655193", "l": "KIAA0101 double monoubiquitination (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31211", "l": "ATP + H2O + L-selenomethionine = diphosphate + L-adenosylselenomethionine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34171", "l": "L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O", "d": []}, {"i": "EC:4.3.3.7", "l": "\"4-hydroxy-tetrahydrodipicolinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8963851", "l": "VD3 dissociates from GC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69764", "l": "a medium-chain fatty aldehyde + H2O + NAD(+) => a medium chain fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49411", "l": "[(1->2)-beta-D-mannosyl](n) + phosphate <=> [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102842", "l": "1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity (SN2-16:3 forming)", "d": ["Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047874", "l": "dolichyldiphosphatase activity", "d": ["Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63155", "l": "an N-fatty acyl-taurine + H2O <=> a fatty acid + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806629", "l": "Formation of tonofilament bundles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36388", "l": "carbamoyl adenylate + kanamycin A => 6''-O-carbamoylkanamycin A + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046559", "l": "alpha-glucuronidase activity", "d": ["Catalysis of the reaction: an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73619", "l": "CTP(out) + GTP(in) = CTP(in) + GTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9619376", "l": "CAMK1 binds calmodulin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32029", "l": "(-)-alpha-cuprenene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694428", "l": "LMAN family proteins bind glycosylated cargo (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29990", "l": "adenosine(in) + H(+)(in) <=> adenosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70806", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate <=> 4-deoxy-4-sulfo-D-erythrose + D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42627", "l": "(Z)-3-ureidoacrylate + H(+) + H2O <=> (Z)-3-aminoacrylate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50175", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48271", "l": "4',4'-dihydroxyechinenone <=> canthaxanthin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.346", "l": "\"phosphatidyl-myo-inositol dimannoside synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35068", "l": "(S)-carnitine(out) => (S)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6790454", "l": "SUMOylation of XPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655170", "l": "RCHY1 monoubiquitinates POLH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.320", "l": "\"benzil reductase [(S)-benzoin forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975175", "l": "MyD88 interacts with the activated TLR receptor 7, 8 or 9  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71679", "l": "H(+)(out) + L-lysyl-glycine(out) = H(+)(in) + L-lysyl-glycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164832", "l": "ATPase synthesizes ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018525", "l": "4-hydroxybenzoyl-CoA reductase activity", "d": ["Catalysis of the reaction: benzoyl-CoA + oxidized ferredoxin + H2O = 4-hydroxybenzoyl-CoA + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21755", "l": "all-trans-violaxanthin <=> all-trans-capsorubin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62771", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.1", "l": "\"1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017025", "l": "TBP-class protein binding", "d": ["Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42709", "l": "guanosine(46) in tRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29093", "l": "a ubiquinol + 4 H(+)(out) + NAD(+) => a ubiquinone + 5 H(+)(in) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675417", "l": "PEBP1 binds activated RAF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199203", "l": "PANK1/3/4 phosphorylate PanK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032033", "l": "myosin II light chain binding", "d": ["Binding to a light chain of a myosin II complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49346", "l": "2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212642", "l": "L-Glutamine transport into neurons (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753634", "l": "GGT dimers hydrolyse APAP-SG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388829", "l": "SHP2 phosphatase binds CTLA-4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74235", "l": "H2O + L-threonyl-tRNA(Ser) = L-threonine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975594", "l": "PLB1 hydrolyses RPALM to atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56067", "l": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10973", "l": "D-hexose + H(+) + phosphoramidate => alpha-D-hexose 1-phosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630921", "l": "NFKBIA variant binds NFkB complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35107", "l": "3-nitrotyramine + H2O + O2 = 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15626", "l": "Co-precorrin-6B + NAD(+) => Co-precorrin-6A + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56123", "l": "2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70980", "l": "4-aminobutanoate(out) + n H(+)(in) => 4-aminobutanoate(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71160", "l": "H(+)(in) + L-serine(out) + Na(+)(out) => H(+)(out) + L-serine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.71", "l": "\"phosphatidyl-N-methylethanolamine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68837", "l": "(2Z,6E)-farnesyl diphosphate => (6R,7S)-himachala-9,11-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60233", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50108", "l": "hexadecanoyl-CoA + taurine = CoA + H(+) + N-hexadecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34013", "l": "ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 => 5-dehydroepisterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25107", "l": "ATP + pyridoxamine <=> ADP + H(+) + pyridoxamine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17521", "l": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate", "d": []}, {"i": "EC:6.3.5.7", "l": "\"glutaminyl-tRNA synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871227", "l": "RET binds GFRA4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0106413", "l": "RNA dihydrouridine synthase activity", "d": ["Catalysis of the reaction: RNA-uracil + NAD(P)+ = RNA-dihydrouridine + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68050", "l": "[protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine => [protein]-D-aspartate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17405", "l": "N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine = H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.105", "l": "\"N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036949", "l": "NTRK3 binds GRB2:SOS1 through SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70884", "l": "H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out) => H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805109", "l": "CDK2 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59021", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59005", "l": "dodecanal + H2O + O2 => dodecanoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174367", "l": "GCL ligates L-Glu to L-Cys (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67099", "l": "2-oxoglutarate + asnovolin A + 2 O2 <=> CO2 + fumigatonoid A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70470", "l": "2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in double-stranded DNA + H2O + O2 <=> a 2'-deoxycytidine in double-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65841", "l": "ATP(out) + Mg(2+)(out) + phosphate(in) => ATP(in) + Mg(2+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66403", "l": "ATP + glutathione(in) + glycocholate(in) + H2O <=> ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75208", "l": "Ag(+)(out) => Ag(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30848", "l": "FAD + glutaryl-CoA + 2 H(+) => (2E)-butenoyl-CoA + CO2 + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-921145", "l": "Activated chicken TAK1 dissociates from the activated TLR3 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63344", "l": "ATP + L-amino acyl-L-threonyl-[protein] = (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5603467", "l": "Activated protein C is released from PROCR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21114", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose => globoside Gb3Cer (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44682", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16004", "l": "H(+) + H2O + N(6)-methyl-AMP <=> IMP + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9732629", "l": "PPARG binds PPARG agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9640195", "l": "RRAGA,B hydrolyzes GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5225649", "l": "RBBP7 binds histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061712", "l": "tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase", "d": ["Catalysis of the reaction: N(6)-L-threonylcarbamoyladenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N(6)-L-threonylcarbamoyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022875", "l": "protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactitol(out) = protein histidine + galactitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102236", "l": "trans-4-hexen-3-one reductase activity", "d": ["Catalysis of the reaction: trans-4-hexen-3-one + NADPH + H+ <=> hexan-3-one + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53261", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62977", "l": "(9Z,12Z,15Z)-octadecatrienamide + H2O => (9Z,12Z,15Z)-octadecatrienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67059", "l": "chermesin D + S-adenosyl-L-methionine <=> chermesin D methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44482", "l": "3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442387", "l": "ZIP8 mediates zinc influx into cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35842", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA <=> a cardiolipin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39120", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 => (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45634", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59396", "l": "L-leucine = D-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14035", "l": "1D-myo-inositol 1-phosphate + glycerol + H(+) => H2O + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53510", "l": "(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20364", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209925", "l": "DIT and MIT combine to form triiodothyronine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21734", "l": "anthranilate + H(+) + L-glutamate + pyruvate => chorismate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51514", "l": "NH4(+) + oxalate => H2O + oxamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395364", "l": "LTBP4 binds TGF-Beta-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102512", "l": "delphinidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside betaine + vanillate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29188", "l": "succinate + ubiquinone-8 => fumarate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61195", "l": "(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849900", "l": "SALMs1-3 bind each other in cis interactions (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77077", "l": "Capping complex formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.54", "l": "\"mucrolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368069", "l": "NR1D1 (REV-ERBA) binds heme, the ARNTL gene, and recruits corepressors. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187264", "l": "Platelet glycoprotein IV (CD36) binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69173", "l": "Joining of adjacent Okazaki fragments (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654163", "l": "Activated FGFR4 binds PLCG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65649", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine => a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38181", "l": "19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70725", "l": "sitosterol(in) => sitosterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23867", "l": "4-CDP-2-C-methyl-D-erythritol 2-phosphate <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655235", "l": "Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050277", "l": "sedoheptulokinase activity", "d": ["Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H+ + sedoheptulose 7-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46234", "l": "(9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72070", "l": "(2S)-2-aminobutanoate + ATP + L-glutamate <=> ADP + gamma-L-glutamyl-(2S)-2-aminobutanoate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24386", "l": "AMP + diphosphate + H(+) + L-glutamate + NAD(+) => ATP + deamido-NAD(+) + H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28387", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine => di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0032813", "l": "tumor necrosis factor receptor superfamily binding", "d": ["Binding to a member of the tumor necrosis factor receptor superfamily."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9688838", "l": "RIPK3 binds STUB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032051", "l": "clathrin light chain binding", "d": ["Binding to a clathrin light chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44862", "l": "CoA + O-4,8-dimethylnonanoyl-(R)-carnitine => (R)-carnitine + 4,8-dimethylnonanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69898", "l": "cytidine(out) + Na(+)(out) <=> cytidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37579", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35147", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) = (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21377", "l": "3-(4-hydroxyphenyl)pyruvate + O2 => (S)-4-hydroxymandelate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73912", "l": "ATP + psilocin => ADP + H(+) + psilocybin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102759", "l": "campestanol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + campestanol + O2 + NADPH <=> 6-deoxycathasterone + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194036", "l": "Cortisol translocates from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12980", "l": "H2O + N-phosphocreatine <=> creatine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736984", "l": "p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 binds MYC gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57880", "l": "3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose = 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36868", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24725", "l": "H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 <=> H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050374", "l": "UDP-galacturonate decarboxylase activity", "d": ["Catalysis of the reaction: H+ + UDP-alpha-D-galacturonate = CO2 + UDP-L-arabinose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23641", "l": "1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 => CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851933", "l": "MET phosphorylates GAB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047096", "l": "androst-4-ene-3,17-dione monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + androst-4-ene-3,17-dione + O2 = A + H2O + testololactone."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0047146", "l": "sterigmatocystin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59150", "l": "AMP + diphosphate + marinoloyl-CoA C => ATP + CoA + marinolate C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41707", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53009", "l": "(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate => di-trans,poly-cis-polyprenyl diphosphate + n diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25060", "l": "(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) => (E)-cinnamate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68603", "l": "ORC5 binds ORC2:ORC3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73697", "l": "dADP(in) + H(+)(in) + phosphate(out) => dADP(out) + H(+)(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57335", "l": "H2O + 3 O2 + 3 propionate 3-nitronate <=> 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197963", "l": "DHFR2 reduces FOLA to DHF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60729", "l": "citral + H2O + NADP(+) => 3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12429", "l": "2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH => benzene-1,2,4-triol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30979", "l": "A + all-trans-lycopene = AH2 + all-trans-3,4-didehydrolycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785409", "l": "NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13071", "l": "ADP + H(+) + phosphoethanolamine => ATP + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65549", "l": "ganglioside Fuc-GM1 + H2O => alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13522", "l": "(R)-lactate + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36176", "l": "1-O-alkylglycerone 3-phosphate + H(+) + NADPH => 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63300", "l": "N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656252", "l": "Defective OGG1 mutants do not excise FapyG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19782", "l": "2-oxoglutarate + 3,5-diiodo-L-tyrosine => 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69726", "l": "(indol-3-yl)acetyl-AMP + CoA <=> (indol-3-yl)acetyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:1990404", "l": "NAD+-protein ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34943", "l": "hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) = arbutin 6-phosphate(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35533", "l": "albonoursin + 2 H2O2 => cyclo(L-phenylalanyl-L-leucyl) + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047597", "l": "6-oxocineole dehydrogenase activity", "d": ["Catalysis of the reaction: 6-oxocineole + H+ + NADPH + O2 = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68750", "l": "alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] => alpha-D-glucose 1-phosphate + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64468", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+) = 4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191303", "l": "FDPS dimer transfers IPPP to GPP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683888", "l": "LMCD1 binds GATA6, sequestering it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036443", "l": "dermatan 6-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43746", "l": "AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2) => ATP + cytidine(34) in tRNA(Ile2) + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607751", "l": "TRAF6 oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48763", "l": "L-threitol + NAD(+) <=> H(+) + L-erythrulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0018635", "l": "(R)-limonene 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: (4R)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4R)-limonene-1,2-epoxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909552", "l": "Phosphorylation of STAT1 at Ser727 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8949580", "l": "F1Fo ATP synthase dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672978", "l": "RAF phosphorylates MAP2K dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021068", "l": "PalmS-ESRs bind CAVs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865605", "l": "BRWD1 binds SMARCA4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062082", "l": "HLA-E specific inhibitory MHC class Ib receptor activity", "d": ["Combining with a MHC class Ib molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39297", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858475", "l": "ppDVL recruits RAC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42468", "l": "2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803063", "l": "RNASEs bind bacterial LPS, PGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72722", "l": "eIF2 activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23965", "l": "(E)-coniferaldehyde + H2O + NADP(+) => (E)-ferulate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050575", "l": "2-(S)-hydroxypropyl-CoM dehydrogenase activity", "d": ["Catalysis of the reaction: 2-(S)-hydroxypropyl-coenzyme M + NAD+ = 2-oxopropyl-coenzyme M + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11657", "l": "ATP + holo-[peptidyl-carrier protein] + L-proline => AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16303", "l": "ADP-D-ribose + H(+) + nicotinamide => H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69287", "l": "a 17beta-hydroxy steroid + NADP(+) <=> a 17-oxo steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72095", "l": "Internal Methylation of mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75938", "l": "ATP + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine <=> 6-O-phospho-N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1214188", "l": "PRDM9 trimethylates histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.126", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44656", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018804", "l": "RAC3 GEFs activate RAC3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50636", "l": "a 3-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381109", "l": "IRE1 binds IRE1 forming dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981610", "l": "Neuroglobin binds oxygen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856930", "l": "EPAS1 (HIF2A) and activated NR3C1 (GCR) bind PTK6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66541", "l": "7-dehydrocholesterol + A + H2O => AH2 + cholesta-5,7-dien-3beta,25-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38935", "l": "cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.11", "l": "\"cyclohexane-1-carbonyl-CoA dehydrogenase (electron-transfer flavoprotein)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13252", "l": "(R)-2-hydroxypropyl-coenzyme M + NAD(+) <=> 2-oxopropyl-coenzyme M + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15434", "l": "(2S)-naringenin + dimethylallyl diphosphate => diphosphate + sophoraflavanone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53883", "l": "ADP-alpha-D-glucose + D-glucose 6-phosphate <=> ADP + alpha,alpha-trehalose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59416", "l": "H2O + O2 + tryptamine = H2O2 + indole-3-acetaldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445699", "l": "ATP Hydrolysis By Myosin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664879", "l": "ATM:PEX5 binds ATM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047109", "l": "(S)-3-hydroxyacid-ester dehydrogenase activity", "d": ["Catalysis of the reaction: ethyl (S)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214847", "l": "Phosphorylated CACT and DL dimer dissociate from the TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617866", "l": "HOXC4 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53814", "l": "(25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin] => cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21210", "l": "L-serine + phosphate => H2O + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58001", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose => (20S)-ginsenoside Rg3 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32721", "l": "(E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936995", "l": "THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190686", "l": "Transport of connexins to the Trans-Golgi Network (TGN) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749647", "l": "CES2 hydrolyzes ASA- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10062", "l": "CoA + H(+) + N-acetyl-D-tryptophan => acetyl-CoA + D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112124", "l": "Oxidative demethylation of 3-meC damaged DNA By ALKBH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38769", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13493", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34712", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine => 15-methylhexadecasphing-4-enine + a fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43821", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14734", "l": "Ag(+)(in) + ATP + H2O => ADP + Ag(+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9011543", "l": "DCA binds PDK2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66922", "l": "(2S)-3-sulfolactaldehyde + D-sedoheptulose 7-phosphate => 6-deoxy-6-sulfo-D-fructose + D-erythrose 4-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17949", "l": "3-hydroxy-1H-quinolin-4-one + O2 = CO + H(+) + N-formylanthranilate", "d": []}, {"i": "EC:1.13.11.47", "l": "\"3-hydroxy-4-oxoquinoline 2,4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24074", "l": "12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62393", "l": "levoglucosan + NAD(+) => 3-dehydrolevoglucosan + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71138", "l": "H(+)(in) + L-histidine(out) + Na(+)(out) <=> H(+)(out) + L-histidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39911", "l": "(2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3-phenylbutanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.107", "l": "\"beta-methylphenylalanine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16260", "l": "alpha,alpha-trehalose + phosphate <=> alpha-D-glucose + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45399", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43391", "l": "1D-myo-inositol 3,4-bisphosphate + H2O <=> 1D-myo-inositol 3-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41255", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14129", "l": "cholate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.176", "l": "\"12alpha-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63755", "l": "kermesate + UDP-alpha-D-glucose <=> carminate + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56006", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72134", "l": "agmatine(out) <=> agmatine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63832", "l": "(6E)-8-methylnon-6-enoyl-CoA + vanillylamine = capsaicin + CoA + H(+)", "d": []}, {"i": "EC:2.3.2.35", "l": "\"capsaicin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182186", "l": "Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46246", "l": "(14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55690", "l": "1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+) => an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047864", "l": "dimethylaniline-N-oxide aldolase activity", "d": ["Catalysis of the reaction: N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59739", "l": "L-cysteinyl-[protein] + tetradecanoyl-CoA <=> CoA + S-tetradecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874849", "l": "CREBRF binds CREB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17056", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate <=> beta-D-fructose 6-phosphate + D-erythrose 4-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.318", "l": "\"eugenol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23003", "l": "(R)-pantoate + NAD(+) <=> (R)-4-dehydropantoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937792", "l": "RUNX3 binds SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983700", "l": "SYK binds the activated BCR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692129", "l": "Expression of PTGDS in testis differentiation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56412", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061649", "l": "ubiquitin modification-dependent histone binding", "d": ["Binding to a histone protein in which a residue has been modified by ubiquitination."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43895", "l": "[sulfur carrier]-H + L-cysteine <=> [sulfur carrier]-SH + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14666", "l": "guanine + H(+) + H2O => NH4(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67013", "l": "a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794523", "l": "SLC22A1 transports Cipro into renal cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008831", "l": "dTDP-4-dehydrorhamnose reductase activity", "d": ["Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009941", "l": "RNASEL cleaves viral ssRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33788", "l": "3'-ketolactose + H2O => 3-keto-beta-D-galactose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033452", "l": "GUG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GUG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174444", "l": "Formation of C-strand Okazaki fragments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390329", "l": "Dephosphorylation of AKT by PP2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24009", "l": "ATP + hypotaurocyamine => ADP + H(+) + N(omega)-phosphohypotaurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34471", "l": "NAD(+) + propanoyl-CoA = acryloyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.95", "l": "\"acryloyl-CoA reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18308", "l": "acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-4-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090682", "l": "GPCR bitter taste receptor activity", "d": ["A G protein-coupled receptor activity that is responsible for the sense of bitter taste."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26279", "l": "Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-4 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45774", "l": "[(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate => [(1->4)-beta-D-mannosyl](n) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34553", "l": "ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate => ATP + cob(II)yrinate c monoamide + H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57227", "l": "glyoxal + GTP <=> N(2)-(1-hydroxy-2-oxoethyl)-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265858", "l": "Activation of ATR by interaction with RAD9-TopBP1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32028", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-cuprenene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0000062", "l": "fatty-acyl-CoA binding", "d": ["Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71833", "l": "chloride(in) + creatine(in) + 2 Na(+)(in) => chloride(out) + creatine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43937", "l": "androst-5-ene-3,17-dione => androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53109", "l": "2-hydroxyestrone + S-adenosyl-L-methionine => 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046421", "l": "methylisocitrate lyase activity", "d": ["Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130194", "l": "ABL phosphorylates WAVEs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35884", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-877281", "l": "PIAS1 binds p-STAT1 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51173", "l": "cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37021", "l": "3-hydroxypyruvate + AH2 + NH4(+) => A + D-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40195", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64129", "l": "H2O + N-octadecanoyl-L-phenylalanine => L-phenylalanine + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682992", "l": "KDM4A,B bind H4K20Me2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762343", "l": "PREDL:ALB dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56754", "l": "a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375131", "l": "Basigin binds CD98 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205306", "l": "Interaction of SHP1 and KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045158", "l": "electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity", "d": ["Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69053", "l": "RFC binding displaces Pol Alpha (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5604929", "l": "Activated protein C binds Protein S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635850", "l": "GLI1 binds HHIP gene, PTCH2 gene and BOC gene promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73757", "l": "Binding of RRN3 to RNA Polymerase I (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.105", "l": "\"all-trans-retinol dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035013", "l": "myosuppressin receptor activity", "d": ["Combining with the peptide myosuppressin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981621", "l": "Neuroglobin:oxygen dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36380", "l": "3-dehydro-4alpha-methylzymosterol + H(+) + NADPH => 4alpha-methylzymosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38252", "l": "hexadecan-1-ol + octadecanoyl-CoA => CoA + hexadecanyl octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19629", "l": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH", "d": []}, {"i": "EC:1.1.1.42", "l": "\"isocitrate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.93", "l": "\"pyrrole-2-carboxylate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2464822", "l": "RDH12 reduces atRAL to atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39978", "l": "2-iminobutanoate + H2O <=> 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613490", "l": "Unwinding of DNA for the nascent HIV-1 transcript: Second Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551453", "l": "PRKG is activated by binding to high levels of cGMP in the absence of WNT signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5333678", "l": "CPNEs bind PL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23963", "l": "H(+) + 2 H2O2 + hexadecanoate <=> CO2 + 3 H2O + pentadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39820", "l": "docosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 2-hydroxydocosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66246", "l": "diphosphate + IC-asc-C9-AMP => ATP + H(+) + IC-asc-C9", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004160", "l": "dihydroxy-acid dehydratase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19610", "l": "adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24169", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64931", "l": "dADP + H2O <=> dAMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210805", "l": "Removal of miRNA passenger strand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58795", "l": "ATP + Fe(III)-petrobactin(out) + H2O <=> ADP + Fe(III)-petrobactin(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70505", "l": "H(+) + isopentenyl phosphate + phosphate => H2O + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62176", "l": "GDP-alpha-D-glucose + H2O = alpha-D-glucose 1-phosphate + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68539", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-cedrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9007882", "l": "IL1F10 is cleaved (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036222", "l": "XTP diphosphatase activity", "d": ["Catalysis of the reaction: XTP + H2O = XMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32431", "l": "(1R,4S)-menthone + H(+) + NADPH + O2 = (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047972", "l": "guanidinopropionase activity", "d": ["Catalysis of the reaction: 3-guanidinopropanoate + H2O = beta-alanine + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16465", "l": "(R)-lactate + 2 Fe(III)-[cytochrome c553] = 2 Fe(II)-[cytochrome c553] + 2 H(+) + pyruvate", "d": []}, {"i": "EC:1.1.2.5", "l": "\"D-lactate dehydrogenase (cytochrome c-553)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70498", "l": "D-glucose(out) + 2 Na(+)(out) <=> D-glucose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614591", "l": "Excess cysteine yields lanthionine and H2S (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34885", "l": "ADP + H(+) + phosphate + selenate(in) => ATP + H2O + selenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.141", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45034", "l": "4 Fe(II)-[cytochrome c] + 5 H(+) + nitrite => 4 Fe(III)-[cytochrome c] + H2O + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.32", "l": "\"palmitoyl-CoA 14-(E/Z)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57652", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 = CMP + ganglioside GM1alpha + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18305", "l": "acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-4-O-acetylneuraminate", "d": []}, {"i": "EC:2.3.1.44", "l": "\"N-acetylneuraminate 4-O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55413", "l": "[phosphate](n) + GTP => [phosphate](n+1) + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047041", "l": "(S)-carnitine 3-dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-carnitine + NAD+ = 3-dehydrocarnitine + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50281", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17926", "l": "alpha-L-arabinopyanose + NAD(+) => H(+) + L-arabinono-1,4-lactone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047557", "l": "3-aci-nitropropanoate oxidase activity", "d": ["Catalysis of the reaction: 3-aci-nitropropanoate + H2O + O2 = 3-oxopropanoate + H2O2 + nitrite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53213", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59329", "l": "D-xylono-1,5-lactone + H2O => D-xylonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50931", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 <=> (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22462", "l": "a 2,3-dehydroacyl-CoA + H(+) + NADPH => a 2,3-saturated acyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443783", "l": "Interaction of NUMB with L1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18942", "l": "a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) => a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9700701", "l": "T-type VDCC bind T-type VDCC blockers (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674019", "l": "BRAP binds KSR1:MARK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875817", "l": "MET phosphorylates STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21399", "l": "(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) <=> CO2 + Na(+)(out) + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66111", "l": "2-oxobutanoate + L-cysteine <=> (2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66799", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601919", "l": "Unknown nuclease cleaves cleaved transposon RNA bound in MeR-PIWIL4:cleaved transposon RNA:TDRD9:MAEL:TDRKH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399995", "l": "Muscarinic Acetylcholine Receptor M3 activates Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13434", "l": "2'-deoxycytidine + H(+) + H2O => 2'-deoxyuridine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9681616", "l": "AP2 binds chlorpromazine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16933", "l": "1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH4(+)", "d": []}, {"i": "EC:3.5.99.7", "l": "\"1-aminocyclopropane-1-carboxylate deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706315", "l": "Active FLT3 binds to SH2B3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70759", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23926", "l": "2',3'-cGAMP + diphosphate => pppGp(2'-5')A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102470", "l": "6C-naringenin dibenzoylmethane tautomer glucosyltransferase activity", "d": ["Catalysis of the reaction: 2,4,4',6-tetrahydroxydibenzoylmethane + UDP-alpha-D-glucose <=> 6C-glucosyl-2-hydroxynaringenin + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52644", "l": "D-xylono-1,4-lactone 5-phosphate + H2O = 5-phospho-D-xylonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983259", "l": "Kinesins move along microtubules consuming ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29206", "l": "dimethyl sulfoxide + menaquinol-8 <=> dimethyl sulfide + H2O + menaquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0031992", "l": "energy transducer activity", "d": ["The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691150", "l": "TFR2 dimer binds 2xholoTF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73622", "l": "CTP(out) + GTP(in) <=> CTP(in) + GTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41408", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11852", "l": "phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73302", "l": "(S)-malate(out) + H(+)(in) + phosphate(in) <=> (S)-malate(in) + H(+)(out) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54226", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphocholine => 2-(prostaglandin H2)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2089971", "l": "Secretion of collagens (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46208", "l": "ATP + CoA + eicosanoate = AMP + diphosphate + eicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035560", "l": "pheophorbidase activity", "d": ["Catalysis of the reaction: pheophorbide a + H2O = pyropheophorbide a + methanol + CO2. The reaction occurs in two steps; pheophoridase catalyzes the conversion of pheophorbide a to a precursor of pyropheophorbide a, C-13(2)-carboxylpyropheophorbide a, by demethylation, and then the precursor is decarboxylated non-enzymatically to yield pyropheophorbide a."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047580", "l": "4-hydroxyproline epimerase activity", "d": ["Catalysis of the reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862700", "l": "CMKLR1 binds Resolvin E1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23748", "l": "ATP + GTP = diphosphate + pppGp(2'-5')A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106341", "l": "omega-hydroxyceramide transacylase activity", "d": ["Catalysis of the reaction: 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine."]}, {"i": "RHEA:55264", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9035484", "l": "CysS248-MPST:TXN2 dissociates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1445149", "l": "14-3-3 binds p-5S,T642-AS160 (TBC1D4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9676255", "l": "Formation of the MLL2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35837", "l": "kanamycin A + NADP(+) => 2'-dehydrokanamycin A + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.413456430472493", "identifiers": [{"i": "GO:0019901", "l": "protein kinase binding", "d": ["Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428273", "l": "SPHK1 phosphorylates SPG to S1P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760402", "l": "ILF3 binds HOXC8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70730", "l": "3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O <=> 6-sulfo-alpha-D-quinovose + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35946", "l": "brevianamide F + dimethylallyl diphosphate <=> deoxybrevianamide E + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202307", "l": "Change of PKC theta conformation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692749", "l": "CDC14A,B bind MAPK6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40939", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH = 1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.8.5", "l": "\"short-chain 2-methylacyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73853", "l": "H(+) + UDP + withanone 27-O-beta-D-glucoside => 27-hydroxywithanone + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16675", "l": "H(+) + phosphate + pyruvate => 3-phosphonopyruvate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27915", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851988", "l": "BTN2A2 binds T cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130619", "l": "TGN-lysosomal vesicle coat assembly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0008477", "l": "purine nucleosidase activity", "d": ["Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623355", "l": "ESR1-dependent CCND1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75591", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate = (11S)-hydroxy-(9S,10S)-epoxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653514", "l": "USP17L2 deubiquitinates RCE1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74373", "l": "a carboxylate(in) + nicotinate(out) => a carboxylate(out) + nicotinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61768", "l": "rebaudioside A + UDP-alpha-D-glucose = H(+) + rebaudioside D + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166817", "l": "Cleavage of C3 by C3 convertases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450422", "l": "KSRP recruits RNA degradation activities (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55407", "l": "[phosphate](n) + UTP <=> [phosphate](n+1) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72025", "l": "nicotinate(out) + urate(in) => nicotinate(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964280", "l": "Active Gq binds BTK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798667", "l": "TDH tetramer oxidises L-Thr to 2A-3OB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205649", "l": "p62 links damaged mitochondria to LC3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950398", "l": "CANX dissociates from IL27:EBI3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.6.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48843", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13089", "l": "6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) = 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite", "d": []}, {"i": "EC:1.7.2.2", "l": "\"nitrite reductase (cytochrome; ammonia-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67484", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}, {"i": "EC:3.6.1.62", "l": "\"5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66675", "l": "4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) <=> 5,7-dihydroxy-4-methylphthalide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005212", "l": "structural constituent of eye lens", "d": ["The action of a molecule that contributes to the structural integrity of the lens of an eye."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11123", "l": "cyanate + 3 H(+) + hydrogencarbonate <=> 2 CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211164", "l": "AKT phosphorylates FOXO1A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58255", "l": "H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] <=> ADP-D-ribose + L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47661", "l": "acetyl-CoA + L-methionine sulfoximine => CoA + H(+) + N-acetyl-L-methionine sulfoximine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44397", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689085", "l": "ATXN3 binds polyUb-PARK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654510", "l": "FGFRL1 binds SPRED1/2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351871", "l": "Caspase-mediated cleavage of Z0-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25266", "l": "2-phenylethylamine + H2O + O2 => 2-phenylacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944257", "l": "Association of procollagen type XXIV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55902", "l": "6-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215406", "l": "PRMT5 binds WDR77 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604719", "l": "NOTCH4 gene transcription is inhibited by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389974", "l": "Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68312", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O = 1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17316", "l": "ATP + L-histidine + tRNA(His) <=> AMP + diphosphate + H(+) + L-histidyl-tRNA(His)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667914", "l": "ALK binds ligand midkine (MDK) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784598", "l": "NPPA(124-151) binds NPR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56586", "l": "propane-1,2-diol => 1,2-epoxypropane + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043877", "l": "galactosamine-6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58146", "l": "AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met) => acetate + ATP + cytidine(34) in elongator tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36540", "l": "hexadecanoyl-CoA + sphinganine => CoA + H(+) + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928608", "l": "LIMK phosphorylates CFL1, inactivating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433981", "l": "Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TICAM1:TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30197", "l": "9,9',15-tri-cis-zeta-carotene + plastoquinol-9 => 15,9'-di-cis-phytofluene + plastoquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694630", "l": "Nsp3:nsp4 binds to nsp6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043760", "l": "acetyldiaminopimelate aminotransferase activity", "d": ["Catalysis of the reaction: N-acetyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-acetyl-2-L-amino-6-oxoheptanedioate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16406", "l": "benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) => benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61640", "l": "H(+) + isophthalyl-CoA = benzoyl-CoA + CO2", "d": []}, {"i": "EC:4.1.1.118", "l": "\"isophthalyl-CoA decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203700", "l": "eNOS translocation from Golgi to Caveolae (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19661", "l": "D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.17", "l": "\"mannitol-1-phosphate 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009927", "l": "histidine phosphotransfer kinase activity", "d": ["Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952996", "l": "E2F7 forms homodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0008821", "l": "crossover junction DNA endonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72288", "l": "2,2-dimethylsuccinate(out) + 3 Na(+)(out) => 2,2-dimethylsuccinate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45437", "l": "H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24609", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) => 2,5-dioxopentanoate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5246478", "l": "APOM binds retinoids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674529", "l": "AAMP binds to TBXA2R (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391377", "l": "Luteinizing hormone receptor can bind LH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042410", "l": "6-carboxyhexanoate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + CoA + pimelate = AMP + diphosphate + H+ + pimelyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391211", "l": "Trace amine-associated receptors can bind trace amines (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65515", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2 <=> 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000246", "l": "delta24(24-1) sterol reductase activity", "d": ["Catalysis of the reaction: ergosterol + NADP+ = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0009883", "l": "red or far-red light photoreceptor activity", "d": ["The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27572", "l": "ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+) => ATP + D-glycero-alpha-D-manno-heptose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809521", "l": "BPIF binds bacteria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25524", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = 9alpha-copalyl diphosphate", "d": []}, {"i": "EC:5.5.1.14", "l": "\"syn-copalyl-diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388809", "l": "CTLA-4 binds B7-1/B7-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008684", "l": "TBK1 phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68354", "l": "3',2'-cGAMP + diphosphate => pppA(2'-5')pG", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12497", "l": "2 Fe(2+) + 4 H2O + O2 => 6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2247513", "l": "STAB1:ligand is endocytosed (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21575", "l": "3-hydroxy-2-methyl-1H-quinolin-4-one + O2 <=> CO + H(+) + N-acetylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071861", "l": "tachykinin receptor binding", "d": ["Binding to a tachykinin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624951", "l": "TNPO1 binds KIF17 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60710", "l": "(1R,3R)-chrysanthemate + 2 H(+) + NADH => (1R,3R)-chrysanthemal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57252", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP = glycolate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050541", "l": "beta,beta-carotene-9',10'-dioxygenase activity", "d": ["Catalysis of the reaction: beta-carotene + O2 = beta-apo-10'-carotenal + beta-ionone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858475", "l": "TNFSF9 binds TNFRSF9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805981", "l": "HMGB1 release from cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56366", "l": "carminomycin + 2 H2O + NADP(+) => 13-dihydrocarminomycin + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62694", "l": "2 H(+) + 2 H2O + 2 tellimagrandin II => 2 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602454", "l": "proMMP9 binds TIMP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21539", "l": "(3S)-hydroxy-3-methylglutaryl-CoA <=> 3-methyl-(2E)-glutaconyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11047", "l": "a haloacetate + H2O <=> a halide anion + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16083", "l": "(2R)-S-methyl-1-thioglycerate + phosphate => (2R)-S-methyl-3-phospho-1-thioglycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16752", "l": "H2O + phosphonoacetate <=> acetate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32540", "l": "(2E)-geranyl diphosphate => (+)-car-3-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23386", "l": "beta-D-glucosyl-(1->4)-D-mannopyranose => D-cellobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56900", "l": "globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine = globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430308", "l": "PARVB interacts with Alpha-actinin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25821", "l": "H2O + O2 + spermidine => 4-aminobutanal + H2O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48550", "l": "[phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol => [phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56232", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O = [(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate", "d": []}, {"i": "EC:3.2.1.82", "l": "\"exo-poly-alpha-digalacturonosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351208", "l": "Spermidine  => N-acetylated spermidine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45340", "l": "[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O = (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+)", "d": []}, {"i": "EC:3.1.1.98", "l": "\"[Wnt protein] O-palmitoleoyl-L-serine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10194", "l": "ADP + H(+) + phosphate + sulfate(in) => ATP + H2O + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44307", "l": "a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA <=> a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.12", "l": "\"glucuronate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17497", "l": "formononetin + UDP-alpha-D-glucose = ononin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15052", "l": "GDP-alpha-D-glucose + H2O <=> D-glucose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48500", "l": "H2O + octanoylglycerol = glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015147", "l": "L-arabinose transmembrane transporter activity", "d": ["Enables the transfer of L-arabinose from one side of a membrane to the other. Arabinose occurs free, for example in the heartwood of many conifers and in the combined states, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides, etc."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-167415", "l": "G-protein alpha subunit is inactivated (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51267", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] <=> (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39129", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209536", "l": "IkB is ubiquitinated and degraded (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25635", "l": "H(+) + S-adenosyl-L-homocysteine + syringetin => laricitrin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70576", "l": "3',5'-cyclic UMP + H2O => H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57575", "l": "7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40694", "l": "1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol <=> 1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58817", "l": "ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2169046", "l": "Degradation of TGF-beta receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40764", "l": "(20S)-ginsenoside Re + H2O => (20S)-ginsenoside Rg1 + L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982017", "l": "Active G alpha (q) binds RGS proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51671", "l": "2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654425", "l": "Activated FGFR4 binds SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420131", "l": "The PACAP receptor binds PACAP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5333051", "l": "RPA1 binds HSF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56703", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649108", "l": "HTR3A pentamer binds 5HT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928624", "l": "EPHBs bind EFNBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216045", "l": "Collagen type I binds integrin alpha11beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70207", "l": "sphinga-4E,14Z-dienine-1-phosphate(in) = sphinga-4E,14Z-dienine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19093", "l": "2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2", "d": []}, {"i": "EC:4.1.1.111", "l": "\"siroheme decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12886", "l": "GDP-alpha-D-mannose + queuosine(34) in tRNA(Asp) => GDP + H(+) + O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050511", "l": "undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696358", "l": "TREM,CD300 binds lipids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109858", "l": "MAP2K2 binds MAPK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804188", "l": "PRDM1 represses TP53 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72311", "l": "glutathione(in) + taurocholate(out) = glutathione(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166753", "l": "Conversion of C4 into C4a and C4b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193641", "l": "IKK-beta is recruited (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50173", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080100", "l": "L-glutamine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-glutamine + 2-oxoglutarate = 2-oxoglutaramate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72256", "l": "dopamine + S-adenosyl-L-methionine => 3-methoxytyramine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993802", "l": "HLCS biotinylates PC:Mn2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252133", "l": "ATP6AP1 binds V-ATPase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854645", "l": "IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655850", "l": "Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799466", "l": "TP53I3 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74258", "l": "XDH oxidizes xanthine to form urate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004825", "l": "methionine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786421", "l": "CHIA hydrolyses chitin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72685", "l": "cholate(in) => cholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45617", "l": "H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13733", "l": "an n-alkanal + NAD(+) = an alk-2-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53920", "l": "ATP + L-threonyl-[Fas-activated protein] = ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004488", "l": "methylenetetrahydrofolate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0034215", "l": "thiamine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36969", "l": "3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA => (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74742", "l": "Phosphorylation of SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59501", "l": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9817575", "l": "ERO1B oxidizes P4HB (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023196", "l": "PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66405", "l": "ATP + glutathione(in) + H2O + taurocholate(in) => ADP + glutathione(out) + H(+) + phosphate + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532603", "l": "Nephrin mediated activation of N-WASP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53757", "l": "allodeoxycholoyl-CoA + cholate => allodeoxycholate + choloyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67837", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72796", "l": "bilirubin-bisglucuronoside(out) => bilirubin-bisglucuronoside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174070", "l": "Association of Cdh1 with the APC/C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851919", "l": "Activated MET binds GAB1 and GRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52907", "l": "15,17(3)-seco-F430-17(3)-acid + ATP <=> ADP + coenzyme F430 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683687", "l": "Nucleoprotein is SUMOylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66772", "l": "ATP + H2O + uroporphyrin I(in) = ADP + H(+) + phosphate + uroporphyrin I(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67659", "l": "2 Fe(III)-[cytochrome c] + NADPH <=> 2 Fe(II)-[cytochrome c] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851866", "l": "MET binds RANBP10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180591", "l": "Vpu:CD4 associates with beta-TrCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51331", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.112", "l": "\"oxaloacetate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102851", "l": "1-18:2-2-16:0-phosphatidylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-16:0-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987007", "l": "p-STAT1 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61261", "l": "H2O + L-glutamine + O2 => 2-oxoglutaramate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0015165", "l": "pyrimidine nucleotide-sugar transmembrane transporter activity", "d": ["Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73206", "l": "D-glucose(out) + H(+)(in) <=> D-glucose(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68806", "l": "alpha-D-glucose + D-glucose => H2O + kojibiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54147", "l": "2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 <=> 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49929", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358790", "l": "RNF41 ubiquitinates ERBB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428625", "l": "Vesicular inhibitory amino acid transport (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65105", "l": "aculene D + L-prolyl-[peptidyl-carrier protein] => aculene B + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875523", "l": "MET binds TNS3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65922", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine => L-kynurenine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373738", "l": "Neurofascin interacts with syntenin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47804", "l": "epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013145", "l": "RAC1 binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9635480", "l": "FadD26, FadD28 transfer adenylyl group to a LCFA (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31918", "l": "ATP + D-maltose <=> ADP + alpha-maltose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0015080", "l": "silver ion transmembrane transporter activity", "d": ["Enables the transfer of silver (Ag) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103099", "l": "UDP-glucose:5-methylthiopentylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 5-methylthiopentylhydroximate <=> H+ + 4-methylthiobutyldesulfoglucosinolate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38466", "l": "a 1-acyl-sn-glycerol + an acyl-CoA <=> a 1,2-diacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445071", "l": "Reinsertion of L1 into the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696146", "l": "AOC2 deaminates TYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15500", "l": "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate <=> 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29998", "l": "ATP + H2O + putrescine(out) <=> ADP + H(+) + phosphate + putrescine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102360", "l": "daphnetin 3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose(2-) + 7,8-dihydroxycoumarin <=> UDP(3-) + 3-O-beta-D-glucosyl-daphnetin + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72722", "l": "eIF2 activation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004711", "l": "ribosomal protein S6 kinase activity", "d": ["Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202127", "l": "eNOS synthesizes NO (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112429", "l": "Formation of FACT complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53315", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0005104", "l": "fibroblast growth factor receptor binding", "d": ["Binding to a fibroblast growth factor receptor (FGFR)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166726", "l": "Activation of MASPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66029", "l": "AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine => (5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034522", "l": "cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene = 1,2-dihydroxy-8-carboxynaphthalene + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18531", "l": "3-methylbutanal + H(+) + NADH => 3-methylbutanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0000064", "l": "L-ornithine transmembrane transporter activity", "d": ["Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid."]}, {"i": "REACT:R-HSA-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34425", "l": "(+)-lariciresinol + H(+) + NADPH => (-)-secoisolariciresinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3772430", "l": "CTNNBIP1 binds beta-catenin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982778", "l": "Growth hormone binds the growth hormone receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433808", "l": "viral dsRNA: TLR3: TICAM1 recruits TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11172", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine", "d": []}, {"i": "EC:2.1.1.13", "l": "\"methionine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004760", "l": "serine-pyruvate transaminase activity", "d": ["Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32426", "l": "(1R,4R)-dihydrocarvone + A <=> (R)-carvone + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177937", "l": "Phosphorylation of EGFR by SRC kinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72993", "l": "2 Na(+)(in) + scyllo-inositol(in) => 2 Na(+)(out) + scyllo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73960", "l": "2-methoxy-4-vinylphenol + H(+) + NADH => 4-ethyl-2-methoxyphenol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050088", "l": "mannose-6-phosphate 6-reductase activity", "d": ["Catalysis of the reaction: D-mannitol 1-phosphate + NADP+ = D-mannose 6-phosphate + 3 H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1008200", "l": "NFE2 binds the beta globin locus control region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14228", "l": "6-hydroxyhexanoate + NAD(+) <=> 6-oxohexanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22538", "l": "(S)-tetrahydropalmatine + H(+) + S-adenosyl-L-homocysteine => (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.8", "l": "\"clostripain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41045", "l": "1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43927", "l": "NAD(+) + pregnenolone <=> H(+) + NADH + pregn-5-ene-3,20-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685156", "l": "ATR phosphorylates RPA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654404", "l": "Activated FGFR2 binds SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-179421", "l": "Degradation of multiubiquitinated Nek2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5082391", "l": "Trimerization of HSF1 in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50554", "l": "prostaglandin B1 => prostaglandin C1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420274", "l": "GIP receptor binds gastric inhibitory peptide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60607", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56124", "l": "A + all-trans-lycopene + dimethylallyl diphosphate + H2O = AH2 + diphosphate + nonaflavuxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11576", "l": "ATP + thiamine = AMP + H(+) + thiamine diphosphate", "d": []}, {"i": "EC:2.7.6.2", "l": "\"thiamine diphosphokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004609", "l": "phosphatidylserine decarboxylase activity", "d": ["Catalysis of the reaction: H+ + phosphatidyl-L-serine = CO2 + phosphatidylethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-383190", "l": "HCO3- transport through ion channel (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19706", "l": "CoA + hexadecanal + NAD(+) => H(+) + hexadecanoyl-CoA + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061666", "l": "UFM1 ligase activity", "d": ["Catalysis of the transfer of UFM1 to a substrate protein via the reaction X-UFM1 + S = X + S-UFM1, where X is either an E2 or E3 enzyme, the X-UFM1 linkage is a thioester bond, and the S-UFM1 linkage is an isopeptide bond between the C-terminal amino acid of UFM1 and the epsilon-amino group of lysine residues in the substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351948", "l": "Mitochondrial recruitment of Drp1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874080", "l": "SRC phosphorylates PTK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50406", "l": "1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein] => (2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044540", "l": "L-cystine L-cysteine-lyase (deaminating)", "d": ["Catalysis of the reaction: L-cystine + H2O = pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102778", "l": "delta9-tetrahydrocannabinolate synthase activity", "d": ["Catalysis of the reaction: cannabigerolate + O2 <=> delta(9)-tetrahydrocannabinolic acid + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69299", "l": "CDT1 binds geminin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55966", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27282", "l": "2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)", "d": []}, {"i": "EC:3.5.1.102", "l": "\"2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29216", "l": "fumarate + menaquinol-8 => menaquinone-8 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60673", "l": "NAD(+) + nerol => H(+) + NADH + neral", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015532", "l": "alpha-ketoglutarate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-ketoglutarate(out) + H+(out) = alpha-ketoglutarate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29822", "l": "ATP + H2O + L-isoleucine(out) <=> ADP + H(+) + L-isoleucine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614614", "l": "Cysteine is degraded to serine and H2S (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30545", "l": "(S)-carnitinyl-CoA + ADP + phosphate => (S)-carnitine + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17834", "l": "3-hydroxyanthranilate + S-adenosyl-L-methionine => 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5099899", "l": "WNT5A binds FZD4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2399913", "l": "atRAL binds to RBP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57887", "l": "diphosphate + H2O + Na(+)(in) <=> H(+) + Na(+)(out) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928654", "l": "Clathrin internalises EPH:EFN complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74707", "l": "Binding of IRS to insulin receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9727607", "l": "MME:Zn2+ binds sacubitrilat (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003987", "l": "acetate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65492", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine", "d": []}, {"i": "EC:1.3.98.7", "l": "\"[mycofactocin precursor peptide]-tyrosine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56901", "l": "globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine => globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35457", "l": "(25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+) => 5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56757", "l": "5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] => 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.260", "l": "\"rRNA small subunit pseudouridine methyltransferase Nep1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75081", "l": "Formation of AT-AC B Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59684", "l": "D-maltohexaose + O2 = D-maltohexaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45920", "l": "16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10099", "l": "a fatty acyl-[ACP] + S-adenosyl-L-methionine <=> an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29704", "l": "L-valine(in) => L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37320", "l": "ATP + glycyl-L-methionine(out) + H2O => ADP + glycyl-L-methionine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45906", "l": "dTDP + epivancomycin + H(+) => devancoaminyl-vancomycin + dTDP-beta-L-vancosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9029680", "l": "Caspase-7 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62874", "l": "H2O + NADP(+) + semiviriditoxin => (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18909", "l": "2,4,6-trichlorophenol + S-adenosyl-L-methionine = 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.136", "l": "\"chlorophenol O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30182", "l": "oxalate + oxidized 2[4Fe-4S]-[ferredoxin] <=> 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32254", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) <=> (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73323", "l": "(2R,3S)-piscidate + (E)-caffeoyl-CoA = cimicifugate D + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17481", "l": "2 cob(I)alamin + H(+) + NAD(+) = 2 cob(II)alamin + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802935", "l": "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168136", "l": "Activated JNKs phosphorylate c-JUN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43029", "l": "L-cysteate => 2-aminoprop-2-enoate + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37859", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA = 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654533", "l": "KRAS4B recycles to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63422", "l": "cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate => 2-hydroxyethylphosphonate + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27425", "l": "(2E,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate", "d": []}, {"i": "EC:4.2.3.47", "l": "\"beta-farnesene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672973", "l": "MAP2Ks phosphorylate MAPKs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14449", "l": "chlorophyllide a + NADP(+) = 3,8-divinyl chlorophyllide a + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804006", "l": "NO and NO2 react to N2O3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44650", "l": "a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29967", "l": "2'-deoxyuridine(in) + H(+)(in) = 2'-deoxyuridine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388605", "l": "POMC(138-176) binds MC2R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45124", "l": "acarbose + ATP = acarbose 7(IV)-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.187", "l": "\"acarbose 7(IV)-phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55948", "l": "A + D-alanine + H2O = AH2 + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64373", "l": "beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O => alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003866", "l": "3-phosphoshikimate 1-carboxyvinyltransferase activity", "d": ["Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391935", "l": "DP1 receptor can bind PGD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693609", "l": "ATM phosphorylates TP53 at S15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38480", "l": "N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine => H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61888", "l": "diosgenin + UDP-alpha-D-glucose = diosgenin 3-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64646", "l": "butyl propanoate + CoA => butan-1-ol + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789160", "l": "Hydrogen peroxide and Fe2+ react to hydroxyl, hydroxide and Fe3+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26119", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.17.7.1", "l": "\"(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30457", "l": "(-)-geosmin => (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199046", "l": "Ligands bind L-selectin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875568", "l": "RAPGEF1 activates RAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61278", "l": "5-amino-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-ornithine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25402", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate <=> (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29313", "l": "FMN + glyoxylate + 2 H(+) + H2O + sulfite => FMNH2 + O2 + sulfoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68910", "l": "AMP + diphosphate + NADP(+) + picolinal => ATP + H(+) + NADPH + picolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34215", "l": "4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) = 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.83", "l": "\"3-succinoylsemialdehyde-pyridine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46489", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212222", "l": "PRC2 recruits DNA methyltransferases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9649733", "l": "mature p21 RAS binds GDP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633051", "l": "EFCAB7:IQCE binds EVC2:EVC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69743", "l": "(S)-2-benzylsuccinate + succinyl-CoA = (S)-2-benzylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004948", "l": "calcitonin receptor activity", "d": ["Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71957", "l": "glutarate(in) + 3 Na(+)(in) => glutarate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016015", "l": "morphogen activity", "d": ["Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021183", "l": "MECP2 mRNA translation is inhibited by miR-132 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40109", "l": "1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2247511", "l": "STAB2:ligand is endocytosed (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390886", "l": "HRH4 binds Hist (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848751", "l": "PTK6 binds AKT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17888", "l": "acetaldehyde <=> acetylene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75172", "l": "Formation of RAD50:MRE11 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62144", "l": "dGMP + dGTP = 2 dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694601", "l": "nsp3-4 cleaves itself (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54908", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH = (4E)-hexenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628737", "l": "NEIL1 G83D does not cleave DHU (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19844", "l": "H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30288", "l": "15-cis-phytoene + 2 a plastoquinone => 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218805", "l": "PKC autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047904", "l": "fructose 5-dehydrogenase activity", "d": ["Catalysis of the reaction: D-fructose + A = 5-dehydro-D-fructose + AH(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63450", "l": "CMP-(2-aminoethyl)phosphonate + diphosphate => (2-aminoethyl)phosphonate + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70949", "l": "L-tryptophan(out) => L-tryptophan(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682011", "l": "LC3 binds ATG7 dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50467", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH <=> 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42236", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.10", "l": "\"UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12668", "l": "a 2-deoxystreptamine antibiotic + acetyl-CoA <=> an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0008028", "l": "monocarboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668831", "l": "CST complex formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247842", "l": "Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64048", "l": "(13Z)-docosenoyl-CoA + sphinganine = CoA + H(+) + N-(13Z-docosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56694", "l": "4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69049", "l": "H2O + hexano-6-lactone => 6-hydroxyhexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39729", "l": "a sphingomyelin(out) => a sphingomyelin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647978", "l": "pro-RAS proteins are farnesylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68285", "l": "hexanoyl-CoA + L-seryl-[protein] => CoA + O-hexanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15653", "l": "ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.105", "l": "\"6-phosphofructo-2-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48662", "l": "8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59451", "l": "dodecan-1-ol + NADP(+) <=> dodecanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012835", "l": "GDIs block activation of RHOA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46899", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) <=> a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052585", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, with a quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a quinone or similar compound."]}, {"i": "EC:1.4.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62177", "l": "GDP-alpha-D-glucose + H2O => alpha-D-glucose 1-phosphate + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15669", "l": "a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13283", "l": "2-methyl-3-oxobutanoyl-CoA + H(+) + NADH => (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51004", "l": "a primary alcohol + 2 Fe(III)-[cytochrome cL] = an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004834", "l": "tryptophan synthase activity", "d": ["Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676595", "l": "TRAFs bind RANK:RANKL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29160", "l": "3 a menaquinol(in) + 2 H(+)(out) + nitrite(out) => 3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46622", "l": "(9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381109", "l": "IRE1 binds IRE1 forming dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76021", "l": "18-hydroxycortisol + H2O + 2 oxidized [adrenodoxin] => cortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53792", "l": "benzylthiol + O2 = benzothialdehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72465", "l": "H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-threonyl-[protein] => L-threonyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23466", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036428", "l": "adenosylcobinamide kinase (GTP-specific) activity", "d": ["Catalysis of the reaction: adenosylcobinamide + GTP = adenosylcobinamide phosphate + GDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28300", "l": "(E)-gamma-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5334794", "l": "FABPs bind LCFAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391935", "l": "DP1 receptor can bind PGD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43712", "l": "ATP + dodecanoate + H(+) = diphosphate + dodecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25844", "l": "(1S,5R)-carveol + NAD(+) = (R)-carvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849094", "l": "ARHGAP35 binds RASA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57347", "l": "3-hydroxy-D-kynurenine + S-adenosyl-L-methionine <=> 3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73606", "l": "CMP(in) + CTP(out) <=> CMP(out) + CTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34341", "l": "(20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin] => (22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373087", "l": "Receptor CCR6 binds CCL20 ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950766", "l": "IL27RA dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420131", "l": "The PACAP receptor binds PACAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015327", "l": "cystine:glutamate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55839", "l": "calcitriol + UDP-alpha-D-glucuronate <=> calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211959", "l": "CYP3A43 6b-hydroxylates TEST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22165", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => globoside Forssman (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40786", "l": "docosanoyl-CoA + H2O <=> CoA + docosanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29098", "l": "5 H(+)(in) + NADH + ubiquinone-8 <=> 4 H(+)(out) + NAD(+) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694723", "l": "Uncoating of SARS-CoV-2 Genome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.176", "l": "\"propanoyl-CoA C-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853793", "l": "p-5Y-RET complexes bind GRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003726", "l": "double-stranded RNA adenosine deaminase activity", "d": ["Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140900", "l": "chloride:bicarbonate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(in) + HCO3-(out) = chloride(out) + HCO3-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57040", "l": "aldehydo-D-apiose = D-apiofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.-", "l": "\"In other compounds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51808", "l": "(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69984", "l": "6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26060", "l": "Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine => methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198611", "l": "AKT phosphorylates IKKalpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52294", "l": "13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166726", "l": "Activation of MASPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374909", "l": "Metabolism of Noradrenaline (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24438", "l": "dihydromethanophenazine => H2 + methanophenazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166387", "l": "The FA anion diffuses away laterally from UCP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66761", "l": "ATP + H2O + kainate(in) => ADP + H(+) + kainate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451366", "l": "Activation of p38MAPK by DSCAM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033286", "l": "ATPase-coupled ectoine transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ectoine(out/in) = ADP + phosphate + ectoine(in/out)."]}, {"i": "RHEA:32787", "l": "ATP + H2O + L-ectoine(out) = ADP + H(+) + L-ectoine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54862", "l": "(1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+) => (2E)-geranial + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374701", "l": "Phosphorylation of DCC by Fyn (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19531", "l": "H(+) + isovitexin 2''-O-beta-D-glucoside + UDP => isovitexin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69264", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate = an isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2317314", "l": "AKT binds PDPK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6802973", "l": "PLK3 phosphorylates CDC25C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442760", "l": "Activation of RasGRF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855186", "l": "I(1,3,4,5)P4 transports from the cytosol to the ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43842", "l": "(3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791186", "l": "Expression of ZBTB17 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874194", "l": "MBTPS2 (S2P) cleaves CREB3L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1454916", "l": "The ABCC family mediates organic anion transport (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25194", "l": "(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) => 3-methylcatechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804955", "l": "ATM phosphorylates MDM2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213208", "l": "Type X collagen associates with collagen type II fibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2317314", "l": "AKT binds PDPK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177942", "l": "EGFR binds EGF ligand (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65488", "l": "3 ATP = 2',3',3'-c-tri-AMP + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62065", "l": "2-deoxy-D-glucose 6-phosphate + NAD(+) => 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40047", "l": "1,2,3-trioctanoylglycerol + H2O = 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64251", "l": "decanoyl-CoA + glycine <=> CoA + H(+) + N-decanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69075", "l": "H2O + O2 + serotonin <=> (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35010", "l": "D-fucose(in) <=> D-fucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37061", "l": "AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA => adenosine(37) in tRNA + L-threonylcarbamoyladenylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55498", "l": "ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65984", "l": "hnu + previtamin D3 = lumisterol 3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3229181", "l": "CALM1:Ca2+ binds CNG channel (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913360", "l": "GM-CSF receptor alpha subunit binds GM-CSF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66789", "l": "N-methyl-L-dopa + O2 => (3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626220", "l": "C2CD3 binds the mother centriole (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24401", "l": "ATP + UMP => ADP + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68081", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O => a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44476", "l": "1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-2-acetyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654510", "l": "FGFRL1 binds SPRED1/2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54447", "l": "a (2R,3S,4S)-leucoanthocyanidin + NADP(+) <=> a (2R,3R)-dihydroflavonol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750666", "l": "ALB binds ST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351948", "l": "Mitochondrial recruitment of Drp1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805426", "l": "CARD8 binds CASP9(1-416) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29547", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine = 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64137", "l": "H2O + N-(9Z-octadecenoyl)-L-asparagine => (9Z)-octadecenoate + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11648", "l": "(-)-menthol + H(+) + NADPH + O2 = 1,4-menthane-3,8-diol + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.46", "l": "\"(-)-menthol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55137", "l": "ATP + D-alanine + H(+) => D-alanyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13957", "l": "4 H2O + O2 + 4 sulfur = 6 H(+) + 2 hydrogen sulfide + 2 sulfite", "d": []}, {"i": "EC:1.13.11.55", "l": "\"sulfur oxygenase/reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2530445", "l": "CD59 inhibits MAC formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318576", "l": "Defective MMACHC does not reduce Cbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351207", "l": "Spermine  => N-acetylated spermine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52403", "l": "4-O-phospho-D-threonate + NAD(+) <=> 3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640195", "l": "RRAGA,B hydrolyzes GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28746", "l": "nitrate(in) + nitrite(out) <=> nitrate(out) + nitrite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60707", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164521", "l": "Insertion of gp41 fusion peptide into the target membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010490", "l": "UDP-4-keto-rhamnose-4-keto-reductase activity", "d": ["Catalysis of the reaction: UDP-4-keto-rhamnose + NADPH = UDP-rhamnose + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.60", "l": "\"2-hydroxy-3-oxopropionate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21360", "l": "ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)", "d": []}, {"i": "EC:2.7.7.1", "l": "\"nicotinamide-nucleotide adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047838", "l": "D-xylose 1-dehydrogenase (NAD) activity", "d": ["Catalysis of the reaction: D-xylose + NAD+ = D-xylonolactone + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48320", "l": "ganglioside GA1 + GDP-beta-L-fucose = ganglioside Fuc-GA1 + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984733", "l": "Kinesin-3 is a dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12634", "l": "benzoate + H(+) + NADH + O2 => (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53771", "l": "allocholate + allodeoxycholoyl-CoA <=> allocholoyl-CoA + allodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156910", "l": "Formation of eEF1B complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13687", "l": "5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH => lathosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62388", "l": "[(1->2)-beta-D-glucosyl](n) + H2O = [(1->2)-beta-D-glucosyl](n-2) + sophorose", "d": []}, {"i": "EC:3.2.1.214", "l": "\"exo beta-1,2-glucooligosaccharide sophorohydrolase (non-reducing end)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54813", "l": "(+)-7-isojasmonate + ATP + L-isoleucine => AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77068", "l": "Activation of GT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16809", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate", "d": []}, {"i": "EC:4.1.3.30", "l": "\"methylisocitrate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655193", "l": "KIAA0101 double monoubiquitination (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55990", "l": "beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878117", "l": "RUNX3 binds ZFHX3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685319", "l": "CX3 complex formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035599", "l": "aspartic acid methylthiotransferase activity", "d": ["Catalysis of the methylthiolation (-SCH3 addition) of the beta-carbon of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42275", "l": "3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] <=> 5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36970", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32976", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15975", "l": "adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+) => 3'-phosphoadenylyl sulfate + estrone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70115", "l": "6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388503", "l": "Oxytocin receptor bind oxytocin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19074", "l": "ATP + L-seryl-[I-kappa-B protein] => ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67995", "l": "AH2 + trichloroethene <=> (Z)-1,2-dichloroethene + A + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67584", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2752115", "l": "SPP1 (osteopontin) binds CD44 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082356", "l": "HSF1-mediated gene expression (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.45", "l": "\"aromatic aldoxime N-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33097", "l": "futalosine => chorismate + inosine + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15632", "l": "a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13544", "l": "H2O + tetrathionate <=> H(+) + sulfate + sulfur + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49258", "l": "2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein] => 2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018811", "l": "cyclohex-1-ene-1-carboxyl-CoA hydratase activity", "d": ["Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805059", "l": "CK2:FACT phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604731", "l": "Autocatalytic activation of MMP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1222376", "l": "NOX2 generates superoxide from oxygen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54027", "l": "2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 <=> (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204873", "l": "Interaction of Tie2 and Shp2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60309", "l": "L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106318", "l": "methane monooxygenase NADPH activity", "d": ["Catalysis of the reaction: methane + NADPH + H+ + O2 = methanol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691150", "l": "TFR2 dimer binds 2xholoTF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28536", "l": "diphosphate + dTMP + H(+) => dTTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32680", "l": "(2E)-geranyl diphosphate + H2O => (2E)-geraniol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12705", "l": "[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68284", "l": "hexanoyl-CoA + L-seryl-[protein] = CoA + O-hexanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30708", "l": "putrescine + pyruvate => 4-aminobutanal + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75250", "l": "acetyl-CoA + N-terminal L-prolyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-prolyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47572", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E)) = CMP + ganglioside GT1b (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033802", "l": "isoliquiritigenin 2'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + isoliquiritigenin = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193964", "l": "CYP21A2 21-hydroxylates PROG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9663511", "l": "BIL binds GSTA1, FABP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.110", "l": "\"aromatic 2-oxoacid reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42219", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629917", "l": "NEIL1 Q282TER does not translocate to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28247", "l": "(R)-pantoate + ATP => (R)-4-phosphopantoate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66614", "l": "methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] => N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709842", "l": "MAVS binds TOMM70 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939201", "l": "ESR dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10089", "l": "sucrose + UDP-alpha-D-galactose => 6(F)-alpha-D-galactosylsucrose + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40946", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660665", "l": "Caspase-8 binds MALT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007539", "l": "CHEK1 phosphorylates E2F6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350440", "l": "FT binds to DS in an adjacent cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607058", "l": "Activated protein C:PROCR binds F2R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75035", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate = 1-hexadecanoyl-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24577", "l": "diphosphate + H2O => H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30094", "l": "a ubiquinone + D-alanine + H2O <=> a ubiquinol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28412", "l": "4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH => 4-(gamma-L-glutamylamino)butanal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39064", "l": "NADP(+) + scyllo-inositol => H(+) + NADPH + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10184", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O = 3-oxoadipate + H(+)", "d": []}, {"i": "EC:3.1.1.24", "l": "\"3-oxoadipate enol-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2995334", "l": "COX15 transforms heme O to heme A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42412", "l": "(2R)-2,3-bisphosphoglycerate + ATP + H(+) = ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate", "d": []}, {"i": "EC:6.5.1.9", "l": "\"cyclic 2,3-diphosphoglycerate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56680", "l": "beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.27", "l": "\"beta-dihydromenaquinone-9 omega-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20912", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene", "d": []}, {"i": "EC:4.2.3.17", "l": "\"taxadiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37363", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 = 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54593", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61415", "l": "ATP + N-(D-erythrulosyl)-cadaverine <=> ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22689", "l": "D-alanine + H2O + O2 => H2O2 + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016515", "l": "interleukin-13 receptor activity", "d": ["Combining with interleukin-13 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797100", "l": "CCNK binds CDK13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43694", "l": "AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] => ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11426", "l": "ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain] => ATP + L-threonyl-[myosin heavy-chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15772", "l": "adenosylcob(III)inamide + ATP <=> adenosylcob(III)inamide phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701549", "l": "AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40021", "l": "(-)-ent-copalol + diphosphate => ent-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26482", "l": "adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA", "d": []}, {"i": "EC:2.5.1.75", "l": "\"tRNA dimethylallyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59178", "l": "AMP + H(+) + O-phospho-L-serine => ADP + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047649", "l": "alkylglycerol kinase activity", "d": ["Catalysis of the reaction: 1-alkyl-sn-glycerol + ATP = 1-alkyl-sn-glycerol 3-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928657", "l": "MMP2,9 cleave EPHB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72474", "l": "citrate(out) + D-threo-isocitrate(in) <=> citrate(in) + D-threo-isocitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38156", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (6E,10E)-geranyllinalool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54648", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}, {"i": "EC:4.2.1.173", "l": "\"ent-8alpha-hydroxylabd-13-en-15-yl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40914", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852200", "l": "Inactivation of LCK by PTPN22 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37326", "l": "glycyl-L-methionine + H2O <=> glycine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42828", "l": "2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.31", "l": "\"2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64179", "l": "H2O + N-(9Z-octadecenoyl)-L-tryptophan <=> (9Z)-octadecenoate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2752115", "l": "SPP1 (osteopontin) binds CD44 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975633", "l": "atROL binds to RBP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805122", "l": "AURKB binds TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55847", "l": "calcidiol + UDP-alpha-D-glucuronate <=> calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24794", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47847", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) <=> CO2 + diphosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802918", "l": "Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39466", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA <=> (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30618", "l": "15-cis-phytoene + 2 A <=> 2 AH2 + all-trans-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73032", "l": "Cd(2+)(out) + H(+)(out) => Cd(2+)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209840", "l": "Two DITs combine to form thyroxine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76078", "l": "a dicarboxylate(in) + L-erythro-7,8-dihydrobiopterin(out) <=> a dicarboxylate(out) + L-erythro-7,8-dihydrobiopterin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624948", "l": "KIF17 enters the cilium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61299", "l": "5-deoxy-alpha-D-ribose 1-phosphate <=> 5-deoxy-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57843", "l": "1D-myo-inositol 1,3-bisphosphate + H2O <=> 1D-myo-inositol 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018785", "l": "RHOBTB2 binds GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53702", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26153", "l": "(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil => 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052662", "l": "zeaxanthin epoxidase activity", "d": ["Catalysis of the reaction: all-trans-zeaxanthin + 4 H+ + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12571", "l": "4-nitrophenol + H(+) + NADH + O2 <=> 4-nitrocatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17222", "l": "dTDP-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419428", "l": "S1PR2-5 bind S1P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112266", "l": "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0004935", "l": "adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691131", "l": "CANDI binds CUL1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28131", "l": "baicalin + H2O => baicalein + D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71252", "l": "L-xylopyranose => L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018850", "l": "chloromuconate cycloisomerase activity", "d": ["Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31037", "l": "(S)-2,3-epoxysqualene + H2O => arabidiol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052641", "l": "benzoic acid glucosyltransferase activity", "d": ["Catalysis of the reaction: benzoic acid + UDP-glucose = benzoic acid glucose ester + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848776", "l": "PTK6 phosphorylates DOK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952419", "l": "SMURFs ubiquitinate RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106251", "l": "N4-acetylcytidine amidohydrolase activity", "d": ["Catalysis of the reaction N4-acetylcytidine +H2O = cytidine + acetate."]}, {"i": "RHEA:62932", "l": "H2O + N(4)-acetylcytidine = acetate + cytidine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018758", "l": "RHOH binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50889", "l": "an N-acylsphingoid base 1-phosphate + H2O => an N-acyl-sphingoid base + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9718020", "l": "PTGFR binds PTGFR agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66468", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O = (17E)-cheilanthenediol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53532", "l": "(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate = (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917693", "l": "ESCRT Disassembly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.2.-", "l": "\"With dinitrogen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74318", "l": "O-isobutanoyl-(R)-carnitine(in) <=> O-isobutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52309", "l": "2-hydroxyglutarate + NADP(+) => 2-oxoglutarate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49510", "l": "2-(phosphinatomethylidene)butanedioate + H2O => phosphinomethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023456", "l": "Dimerization of FGFR1 point mutants with enhanced kinase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793988", "l": "LUBAC ubiquitinates CFLAR at K351, K353 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33402", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) <=> L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43542", "l": "ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase] => ATP + L-seryl-[isocitrate dehydrogenase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686578", "l": "Activated ATM phosphorylates ABL1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27836", "l": "a menaquinol + fumarate => a menaquinone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46491", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29541", "l": "a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36259", "l": "a 1-(1-hydroxyalkyl)-sn-glycerol = an aldehyde + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74477", "l": "(-)-4'-methoxycyclopenine + CO2 + succinate => (Z)-4'-methoxydehydrocyclopeptine + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093327", "l": "EPHA binds TIAM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71878", "l": "2 Na(+)(out) + taurocholate(out) <=> 2 Na(+)(in) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14230", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38870", "l": "uridine(516) in 16S rRNA <=> pseudouridine(516) in 16S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43396", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30067", "l": "betaine aldehyde + H2O + NADP(+) = glycine betaine + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36758", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose <=> beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56429", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680443", "l": "ROCK1,2 bind ROCKi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11346", "l": "a CMP-N-acyl-beta-neuraminate + diphosphate => an N-acylneuraminate + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60958", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP => 17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202713", "l": "CD84 homodimerises (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51330", "l": "10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47142", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55190", "l": "5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate => 5-methyluridine(54) in tRNA + ATP + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57170", "l": "2-oxoglutarate + FADH2 => (R)-2-hydroxyglutarate + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72174", "l": "2 Na(+)(out) + taurohyocholate(out) <=> 2 Na(+)(in) + taurohyocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55090", "l": "(24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine => eburicol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42947", "l": "cytidine(40) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31624", "l": "L-olivosyl-oleandolide + S-adenosyl-L-methionine => H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38560", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate => (R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14772", "l": "(S)-nicotine + A + H2O <=> (S)-6-hydroxynicotine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018807", "l": "6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity", "d": ["Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58680", "l": "A + FADH2 = AH2 + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46481", "l": "4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099620", "l": "UDP-4-amino-4-deoxy-L-arabinose aminotransferase", "d": ["Catalysis of the reaction: UDP-4-amino-4-deoxy-beta-L-arabinopyranose + 2-oxoglutarate = UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47958", "l": "H(+) + maleate + pyruvate => 3-maleylpyruvate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411373", "l": "NLK translocates to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050363", "l": "tryptophan dehydrogenase activity", "d": ["Catalysis of the reaction: L-tryptophan + NAD(P)+ = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005291", "l": "high-affinity L-histidine transmembrane transporter activity", "d": ["Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001792", "l": "polymeric immunoglobulin receptor activity", "d": ["Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51445", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11987", "l": "AH2 + O2 + progesterone <=> A + H2O + testosterone acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701485", "l": "Active ALK binds JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43239", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O <=> 1,2-dihexadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39740", "l": "3-hydroxydodecanoate + H(+) + NADPH + O2 => 3,12-dihydroxydodecanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:1902945", "l": "metalloendopeptidase activity involved in amyloid precursor protein catabolic process", "d": ["Any metalloendopeptidase activity that is involved in amyloid precursor protein catabolic process."]}, {"i": "REACT:R-HSA-9010034", "l": "ADAM10:Zn2+:TSPANs cleaves APP(18-770) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16728", "l": "a phosphatidylglycerol phosphate + H2O <=> a phosphatidylglycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686587", "l": "ABL1 phosphorylates RAD52 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42044", "l": "GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E)) = GDP + globoside Globo-H (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654159", "l": "Activated FGFR2 binds PLCG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37010", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007615", "l": "E2F6 binds RBBP8 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25658", "l": "(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] = (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.143", "l": "\"(+)-menthofuran synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938108", "l": "SERPINB13 binds cathepsin L (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21845", "l": "L-glutamine + phenylacetyl-CoA => CoA + H(+) + N(2)-phenylacetyl-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67302", "l": "3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one => (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16236", "l": "(R)-pantoate + NADP(+) <=> 2-dehydropantoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59449", "l": "dodecan-1-ol + NADP(+) => dodecanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54788", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide = [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29856", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine => D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24225", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) => 4-methylcatechol + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24643", "l": "ergosteryl 3-beta-D-glucoside + H2O <=> D-glucose + ergosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197958", "l": "FPGS-2 transforms THF to THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41485", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213244", "l": "Loading of antigenic peptides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11081", "l": "dTMP + H2O => phosphate + thymidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17714", "l": "(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58330", "l": "(Z)-non-6-enal + H(+) + NADPH => (Z)-non-6-en-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109339", "l": "Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3321805", "l": "NSL acetylates histone H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10839", "l": "NADPH + O2 + questin <=> demethylsulochrin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32437", "l": "4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => dihydrocarvone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11771", "l": "diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate <=> 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64061", "l": "(S)-phenylacetylcarbinol + NAD(+) => 1-phenyl-1,2-propanedione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37923", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047773", "l": "carnitinamidase activity", "d": ["Catalysis of the reaction: (R)-carnitinamide + H2O = (R)-carnitine + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784598", "l": "NPPA(124-151) binds NPR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24233", "l": "2-dehydro-3-deoxy-D-gluconate + NAD(+) => 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8876789", "l": "CARNMT1 methylates CARN to Anserine (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15895", "l": "Co(2+) + sirohydrochlorin => Co-sirohydrochlorin + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60399", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O <=> Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18994", "l": "(9Z,12Z)-octadecadienoate + O2 => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38814", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28228", "l": "capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9686088", "l": "CASP3 cleaves GSDMD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71831", "l": "chloride(out) + creatine(out) + 2 Na(+)(out) = chloride(in) + creatine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165129", "l": "GDP is exchanged for GTP on DRheb (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381087", "l": "Dimerization of PERK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20587", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin => loganin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11693", "l": "NAD(+) + NADPH => NADH + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31585", "l": "2-oxo-dAMP + diphosphate + H(+) => 2-oxo-dATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18650", "l": "D-galactonate => 2-dehydro-3-deoxy-D-galactonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36189", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8856951", "l": "PP2A demethylation by PPME1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36454", "l": "ATP + glycyl-L-glutamate(out) + H2O <=> ADP + glycyl-L-glutamate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174097", "l": "Association of Emi1 with Cdh1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951486", "l": "CD46 binds C4b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700175", "l": "Active ALK phosphorylates SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72327", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + vanillate = 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10811", "l": "(S)-2-hydroxypropylphosphonate + H2O2 <=> (1R,2S)-epoxypropylphosphonate + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392064", "l": "G alpha (z) inhibits adenylate cyclase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70050", "l": "2-oxoadipate + L-kynurenine <=> H2O + kynurenate + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75286", "l": "decanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxydecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229132", "l": "AP4 binds APP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65204", "l": "(3R)-3-hydroxybutanoyl-CoA + H2O = (R)-3-hydroxybutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070835", "l": "chromium ion transmembrane transporter activity", "d": ["Enables the transfer of chromium (Cr) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46433", "l": "(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.5.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72421", "l": "(E)-4-coumaroyl-AMP + diphosphate => (E)-4-coumarate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186786", "l": "Autophosphorylation of PDGF beta receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53519", "l": "1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10471", "l": "D-xylulose 5-phosphate + phosphate <=> acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24139", "l": "3'-phosphoadenylyl sulfate + a primary amine <=> a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690023", "l": "NUBPL binds 4Fe-4S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21652", "l": "2-chlorobenzoate + H(+) + NADH + O2 = catechol + chloride + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75745", "l": "10-hydroxy-(11E)-octadecenoate + NAD(+) => 10-oxo-(11E)-octadecenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022465", "l": "MECP2 mutants R106W, D121G, R133H, S134F, T158M and T158A do not bind to 5mC-DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395364", "l": "LTBP4 binds TGF-Beta-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45747", "l": "(6S)-5,6,7,8-tetrahydropteroate + NAD(+) <=> 7,8-dihydropteroate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353475", "l": "Association of the XRCC4:DNA ligase IV complex with the DNA-PK:DNA synaptic complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.16", "l": "\"succinate-semialdehyde dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71099", "l": "androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) = androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167415", "l": "G-protein alpha subunit is inactivated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10493", "l": "H2O + phosphocholine => choline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35803", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24911", "l": "L,L-cystathionine => 2-aminobut-2-enoate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41170", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31909", "l": "(S)-coclaurine + H(+) + S-adenosyl-L-homocysteine => (S)-norcoclaurine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788061", "l": "Fibronectin degradation by ADAM8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62550", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9646468", "l": "mTORC1 binds RHEB:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24361", "l": "2 H(+) + siroheme => Fe(2+) + sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27307", "l": "A + D-proline => 1-pyrroline-2-carboxylate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2974737", "l": "NOTCH2 binds MDK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018858", "l": "benzoate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102993", "l": "linolenate delta15 desaturase activity", "d": ["Catalysis of the reaction: O2 + a lipid linoleoyl group + a reduced electron acceptor <=> 2 H2O + a lipid alpha-linolenoyl group + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40929", "l": "(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54686", "l": "(-)-kolavenyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70332", "l": "3-hydroxyphenylacetyl-CoA + H2O => 3-hydroxyphenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372697", "l": "Crk binding to p130cas (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005250", "l": "A-type (transient outward) potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential."]}, {"i": "REACT:R-HSA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685268", "l": "SARS-CoV-1 8b binds NLRP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010641", "l": "AKAP5 recruits PKA to ROBO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14801", "l": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP", "d": []}, {"i": "EC:2.7.2.3", "l": "\"phosphoglycerate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9702818", "l": "CALCR binds erenumab (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15606", "l": "H2O + L-serine O-sulfate => H(+) + NH4(+) + pyruvate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21211", "l": "H2O + O-phospho-L-serine <=> L-serine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.21", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.535054500181104", "identifiers": [{"i": "GO:0016841", "l": "ammonia-lyase activity", "d": ["Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate."]}, {"i": "EC:4.3.1.-", "l": "\"Ammonia-lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53518", "l": "(11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69022", "l": "H2O + N-hydroxy-L-aspartate + NADP(+) => L-aspartate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10098", "l": "an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine => a fatty acyl-[ACP] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53944", "l": "2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) = (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9728664", "l": "GLP1R binds GLP1R agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140741", "l": "tRNA U4 sulfurtransferase", "d": ["Catalyzes the reaction: ATP + [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + uracil in tRNA + 2 reduced ferredoxin [iron-sulfur] cluster <=> AMP + diphosphate + 4-thiouracil in tRNA + [ThiI sulfur-carrier protein]-L-cysteine + 2 oxidized ferredoxin [iron-sulfur] cluster."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004748", "l": "ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor", "d": ["Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848751", "l": "PTK6 binds AKT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168910", "l": "RIP1 facilitates IKK complex phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691421", "l": "BTK binds BTK inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36585", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH => dTDP-alpha-D-fucose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74429", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + H(+)(in) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20061", "l": "2'-deoxycytidine + a ribonucleoside 5'-triphosphate = a ribonucleoside 5'-diphosphate + dCMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698174", "l": "FLT3 mutants recruit PIK3CA through PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14533", "l": "creatinine + H2O = creatine", "d": []}, {"i": "EC:3.5.2.10", "l": "\"creatininase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26399", "l": "2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde => all-trans-zeaxanthin + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42282", "l": "11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44261", "l": "2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA => 4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9619756", "l": "NR1H2 binds ABCA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18052", "l": "2-oxoglutarate + N(2)-acetyl-L-ornithine <=> L-glutamate + N-acetyl-L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25547", "l": "ent-copalyl diphosphate <=> diphosphate + ent-pimara-9(11),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956586", "l": "RUNX1-containing TAL1 complex binds the MYB gene enhancer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62345", "l": "6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate => diphosphate + notoamide S", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938815", "l": "RNF152 polyubiquitinates RRAGA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193702", "l": "Part of the ICD migrates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34160", "l": "acetyl-CoA + UDP-N-acetylbacillosamine => CoA + H(+) + UDP-N,N'-diacetylbacillosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198669", "l": "p38MAPK phosphorylates MSK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14102", "l": "[eIF5A protein]-deoxyhypusine + AH2 + O2 => [eIF5A protein]-hypusine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29358", "l": "dUMP + H2O <=> 2'-deoxyuridine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3244605", "l": "TREX1 binds retroviral-derived DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41262", "l": "L-tryptophan <=> (E)-3-(indol-3-yl)acrylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043958", "l": "acryloyl-CoA reductase (NADH) activity", "d": ["Catalysis of the reaction: propanoyl-CoA + NAD+ = acryloyl-CoA + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20612", "l": "2-dehydro-3-deoxy-D-arabinonate <=> glycolaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73833", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54954", "l": "AMP + diphosphate + nonanoyl-CoA => ATP + CoA + nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60564", "l": "2-deoxy-D-glucose + ATP = 2-deoxy-D-glucose 6-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.3", "l": "\"Delta(4)-3-oxosteroid 5beta-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168272", "l": "Binding of the influenza virion to the host cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70275", "l": "H2O + raffinose = D-galactose + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0051192", "l": "prosthetic group binding", "d": ["Binding to a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56177", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O => 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448744", "l": "IL20RA binds IL20RB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004020", "l": "adenylylsulfate kinase activity", "d": ["Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2160931", "l": "Disassembly of tight junctions (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69086", "l": "acrylate + 2 H(+) + NADH => acrolein + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980138", "l": "NOTCH1 binds DLL/JAG ligand in cis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62905", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27826", "l": "hydrogen sulfide + O-succinyl-L-homoserine = L-homocysteine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54666", "l": "pre-alpha-onocerin => (3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683925", "l": "ULK1 is dephosphorylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75049", "l": "N(omega),N(omega)-dimethyl-L-arginine(in) => N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70241", "l": "PCK1 phosphorylates OA to yield PEP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730858", "l": "Autophosphorylation of BTK/ITK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75104", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 32-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.47", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222417", "l": "TrxA reactivates AhpC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426209", "l": "DAG activation of TRPC channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649735", "l": "Intrinsic nucleotide exchange on RAS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64402", "l": "an L-amino acid tripeptide(in) + H(+)(in) => an L-amino acid tripeptide(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45140", "l": "2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O = CO2 + L-glutamyl-[protein] + O2 + phylloquinol", "d": []}, {"i": "EC:4.1.1.90", "l": "\"peptidyl-glutamate 4-carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446634", "l": "IRAK4 is activated by autophosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451505", "l": "Dissociation of phospho ERK2 :phospho MEK2 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451942", "l": "Within the IL-2R complex JAK3 phosphorylates JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748996", "l": "GST dimers cleave AZA to 6MP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195251", "l": "Assembly of the destruction complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75001", "l": "deoxyerythrostominol(out) => deoxyerythrostominol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16748", "l": "AH2 + O2 + phylloquinone <=> 2,3-epoxyphylloquinone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050249", "l": "Renilla-luciferin sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + Renilla luciferin = adenosine 3',5'-diphosphate + H+ + luciferyl sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38751", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665989", "l": "DIAPH1 binds RHOA:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.75", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57675", "l": "(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] <=> 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41414", "l": "1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672951", "l": "Inactive RAFs bind YWHAB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964280", "l": "Active Gq binds BTK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2429719", "l": "MCPH1 sequesters condensin II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951486", "l": "CD46 binds C4b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75627", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + H2O = ectocarpin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48744", "l": "(-)-yatein + 2-oxoglutarate + O2 = (-)-deoxypodophyllotoxin + CO2 + H2O + succinate", "d": []}, {"i": "EC:1.14.20.8", "l": "\"(-)-deoxypodophyllotoxin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32715", "l": "(2R,3S)-3-methylmalate + NAD(+) = 2-oxobutanoate + CO2 + NADH", "d": []}, {"i": "EC:1.1.1.n5", "l": "\"3-methylmalate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10996", "l": "2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.91", "l": "\"isobutyraldoxime O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.28", "l": "\"2-phospho-L-lactate transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20205", "l": "methylazoxymethanol + UDP-alpha-D-glucose = cycasin + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.171", "l": "\"methyl-ONN-azoxymethanol beta-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047618", "l": "acylagmatine amidase activity", "d": ["Catalysis of the reaction: N(4)-benzoylagmatine + H2O = agmatine + benzoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416562", "l": "p190RhoGAP binds Plexin-B1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68895", "l": "3-methoxybenzoate + ATP + H(+) + NADPH <=> 3-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28104", "l": "D-mannose + GDP + H(+) => GDP-alpha-D-mannose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31374", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine <=> (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51417", "l": "a (2S,3R)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754974", "l": "ADK phosphorylates RBV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19674", "l": "1,2,3-trihydroxybenzene + O2 => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35448", "l": "(1'S)-averantin + NADP(+) => H(+) + NADPH + norsolorinic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759358", "l": "NFE2L2-dependent SRXN1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52923", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390909", "l": "HRH2 binds hist (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805981", "l": "HMGB1 release from cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49830", "l": "(2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76416", "l": "Benzene is hydroxylated to phenol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35499", "l": "11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.115", "l": "\"11-oxo-beta-amyrin 30-oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418553", "l": "cAMP degradation by Phosphodiesterases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2301205", "l": "SETD8 monomethylates histone H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052747", "l": "sinapyl alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: sinapaldehyde + NADPH + H+ = sinapyl-alcohol + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954056", "l": "E2F6 binds TFDP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57312", "l": "H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine = cytidine 5'-diphosphoramidate + H(+) + L-glutamate", "d": []}, {"i": "EC:3.5.1.129", "l": "\"N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0052885", "l": "all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity", "d": ["Catalysis of the reaction: H2O + all-trans-retinyl ester = 11-cis-retinol + fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45897", "l": "an N-acyl-sphingoid base + CDP-ethanolamine => an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50788", "l": "NADP(+) + pentan-2-one = (E)-pent-3-en-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029451", "l": "Activation of RAC1 by VAV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005477", "l": "pyruvate secondary active transmembrane transporter activity", "d": ["Enables the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047117", "l": "enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-D2-enoyl-[acyl-carrier protein] + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218815", "l": "p-6Y-VEGFR2 binds NCK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40127", "l": "an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202241", "l": "Recruitment of SLP-76 to Gads (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29948", "l": "H(+)(in) + L-rhamnopyranose(in) => H(+)(out) + L-rhamnopyranose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19725", "l": "H(+) + UDP-alpha-D-galacturonate = CO2 + UDP-beta-L-arabinopyranose", "d": []}, {"i": "EC:4.1.1.67", "l": "\"UDP-galacturonate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75539", "l": "(2E)-decenoate + ATP + holo-[ACP] = (2E)-decenoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62482", "l": "2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33426", "l": "N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) <=> diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17073", "l": "acetyl-CoA + cortisol = CoA + cortisol 21-acetate", "d": []}, {"i": "EC:2.3.1.27", "l": "\"cortisol O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444647", "l": "C3a receptor binds anaphylatoxin C3a (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.58", "l": "\"caspase-5\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.60", "l": "\"dactylysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65591", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5334794", "l": "FABPs bind LCFAs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57558", "l": "2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1 => (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75172", "l": "Formation of RAD50:MRE11 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.21", "l": "\"Cd(2+)-exporting ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40801", "l": "2-methylpropanoate + CoA + H(+) => 2-methylpropanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53728", "l": "H2O + N-acetyl-D-muramate 6-phosphate = N-acetyl-D-muramate + phosphate", "d": []}, {"i": "EC:3.1.3.105", "l": "\"N-acetyl-D-muramate 6-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31245", "l": "(4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH => H2O + L-4-hydroxyglutamate semialdehyde + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27676", "l": "ADP + dATP => ATP + dADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691154", "l": "HFE binds TFRC dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212222", "l": "PRC2 recruits DNA methyltransferases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67989", "l": "N-acetyl-L-glutamine => N-acetyl-D-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734713", "l": "ORC6 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855375", "l": "PTPN22 dissociates from CSK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50341", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone => 1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034954", "l": "diphenyl ether 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: diphenyl ether + O2 = 2,3-dihydroxydiphenyl ether."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0051752", "l": "phosphoglucan, water dikinase activity", "d": ["Catalysis of the reaction: ATP + [phospho-alpha-glucan] + H2O = AMP + O-phospho-[phospho-alpha-glucan] + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034869", "l": "2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + OH- = 2,4,4-trimethyl-3-oxopentanoate + CoASH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50278", "l": "(12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40803", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) = 3,6-anhydro-L-galactonate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220612", "l": "Binding of EGF to ligand-responsive EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70364", "l": "cyanurate + H2O => 1-carboxybiuret + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.16", "l": "\"levan fructotransferase (DFA-IV-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6805640", "l": "AKT phosphorylates KAT6A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48288", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM3 = CMP + ganglioside GD3 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.850581069382244", "identifiers": [{"i": "GO:0046914", "l": "transition metal ion binding", "d": ["Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38517", "l": "(9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) => 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70370", "l": "3-oxosphinganine + octanoyl-CoA <=> CoA + H(+) + N-octanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70928", "l": "(R)-glycerate(in) + H(+)(in) => (R)-glycerate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63870", "l": "(2R,9Z)-2-hydroperoxyoctadecenoate => (9Z)-octadecenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004135", "l": "amylo-alpha-1,6-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2545203", "l": "Deacetylation of cleaved cohesin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029984", "l": "Autocatalytic phosphorylation of FGFR2 ligand-independent  mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043027", "l": "cysteine-type endopeptidase inhibitor activity involved in apoptotic process", "d": ["Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49965", "l": "5,10-dihydrophenazine + O2 => H2O2 + phenazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17181", "l": "a long-chain fatty aldehyde + FMNH2 + O2 = a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu", "d": []}, {"i": "EC:1.14.14.3", "l": "\"bacterial luciferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33603", "l": "H(+) + N-hexacosanoylsphinganine + NADPH + O2 = H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610720", "l": "PKA phosphorylates GLI3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65271", "l": "3-hydroxypentacecilide A + H(+) + NADPH + O2 <=> chrodrimanin F + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004098", "l": "cerebroside-sulfatase activity", "d": ["Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54967", "l": "hexadecanoyl-[ACP] + phosphate <=> hexadecanoyl phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20231", "l": "2,3-dihydroxybenzoyl-5'-AMP + diphosphate => 2,3-dihydroxybenzoate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52106", "l": "an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+) => a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36166", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate <=> ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964278", "l": "G protein alpha (s):GTP binds SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9604328", "l": "AKT1 phosphorylates NOTCH4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430183", "l": "NCK binds PAK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627104", "l": "XIAP binds CASP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31482", "l": "soyasapogenol A + UDP-alpha-D-glucuronate <=> H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686345", "l": "SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29644", "l": "D-maltoheptaose + H2O => alpha-D-glucose + D-maltohexaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675656", "l": "EDA:EDAR binds EDARADD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13686", "l": "lathosterol + NADP(+) => 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990313", "l": "type-III cohesin domain binding", "d": ["Binding to a type-III cohesin domain of a protein. Type-III cohesin domain is the binding partner of type-III dockerin domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62800", "l": "2 7-demethylsiderin + NADPH + O2 = 2 H2O + NADP(+) + orlandin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63677", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73757", "l": "Binding of RRN3 to RNA Polymerase I (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66669", "l": "5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase] => 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70510", "l": "LDH tetramer oxidises LACT to PYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28543", "l": "fluoroacetyl-CoA + H2O => CoA + fluoroacetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19994", "l": "[thioredoxin]-disulfide + H2O + L-methionine => [thioredoxin]-dithiol + L-methionine (S)-S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38731", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33535", "l": "H2O + lanosteryl ester = a carboxylate + H(+) + lanosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53934", "l": "19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38256", "l": "(S)-malate + succinyl-CoA => (S)-malyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814674", "l": "Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61364", "l": "ATP + dehydroepiandrosterone 3-sulfate(in) + H2O = ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68732", "l": "ganoderate DM + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hainanate A + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68186", "l": "a medium chain fatty acid + CoA + H(+) => a medium-chain fatty acyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35476", "l": "(1'S,5'S)-5'-hydroxyaverantin + NAD(+) => (S)-5'-oxoaverantin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35692", "l": "(2S)-versicolorone + NADP(+) => 1'-hydroxyversicolorone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37014", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604712", "l": "Initial activation of proMMP7 by trypsin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32537", "l": "4-hydroxy-2-oxohexanoate => (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20421", "l": "alpha-maltose 6'-phosphate + H2O = D-glucose + D-glucose 6-phosphate", "d": []}, {"i": "EC:3.2.1.122", "l": "\"maltose-6'-phosphate glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250947", "l": "B-WICH complex binds rDNA promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25709", "l": "H(+) + N,N-dihydroxy-L-dihomomethionine <=> (E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0033971", "l": "hydroxyisourate hydrolase activity", "d": ["Catalysis of the reaction: 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008684", "l": "TBK1 phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52140", "l": "a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O = a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)", "d": []}, {"i": "EC:3.6.1.72", "l": "\"DNA-3'-diphospho-5'-guanosine diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38854", "l": "H(+) + tetracenomycin F2 <=> H2O + tetracenomycin F1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56456", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = 12-epi-fischerindole U", "d": []}, {"i": "EC:5.5.1.33", "l": "\"12-epi-fischerindole U synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21751", "l": "(S)-lactaldehyde + NADP(+) <=> H(+) + methylglyoxal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36129", "l": "O-methyl gibberellin A34 + S-adenosyl-L-homocysteine => gibberellin A34 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62752", "l": "H2O + pravastatin lactone = (S)-2-methylbutanoate + H(+) + pravastatin diol lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42288", "l": "6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098607", "l": "methylselenocysteine deselenhydrase activity", "d": ["Catalysis of the reaction: Se-Methyl-L-selenocysteine + H2O => pyruvic acid + NH3 + Methaneselenol."]}, {"i": "REACT:R-HSA-2408539", "l": "MeSec is hydrolysed to MeSeH by PXLP-K212-CTH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433456", "l": "Recruitment of STATs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62554", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP => beta-D-glucosylceramide + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34285", "l": "2 L-dopa => 2 L-tyrosine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717841", "l": "holo-FDPS dimer binds NBPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26156", "l": "D-mannose + NADP(+) = D-glucosone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.990900157612501", "identifiers": [{"i": "GO:0008173", "l": "RNA methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule."]}, {"i": "REACT:R-HSA-191784", "l": "snRNA Cap hypermethylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454699", "l": "AMPK-alpha2 phosphorylates TBC1D1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51124", "l": "uridine in snRNA = pseudouridine in snRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65590", "l": "4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-casbene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708292", "l": "DICER1 cleaves tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709918", "l": "PTK6 phosphorylates STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654409", "l": "Activated FGFR3 binds FRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112385", "l": "Addition of nucleotides leads to transcript elongation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875374", "l": "MET binds LRIG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11443", "l": "2,3,5,6-tetrachlorophenol + NADPH + O2 <=> 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351894", "l": "Caspase mediated cleavage of BAP31 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013009", "l": "RHOA binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31713", "l": "11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53842", "l": "7,12-dioxo-lithocholate + H(+) + NADPH => 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938231", "l": "RUNX1:CBFB binds CREBBP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-996727", "l": "REST recruits the BHC complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875531", "l": "MET binds TNS4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47216", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332359", "l": "Active calmodulin binds CAMK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47626", "l": "1-pyrroline-2-carboxylate + H2O => cis-3-hydroxy-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854209", "l": "TBC1D10A binds JFC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36564", "l": "GDP-beta-L-colitose + NADP(+) => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877192", "l": "RUNX1 binds FOXP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13884", "l": "a quinone + an aldehyde + H2O <=> a carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64999", "l": "ATP + H(+) + octanoate <=> diphosphate + octanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975040", "l": "KRAB-ZNF / KAP Interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165195", "l": "GTP loading by Rheb (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68573", "l": "L-tyrosine(in) => L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44614", "l": "2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-874087", "l": "SGT1 binds HSP90 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26171", "l": "3-fumarylpyruvate + H2O <=> fumarate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12534", "l": "coenzyme M-coenzyme B heterodisulfide + methane => coenzyme B + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203700", "l": "eNOS translocation from Golgi to Caveolae (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25436", "l": "(2E,6E)-farnesyl diphosphate = (E,R)-alpha-bisabolene + diphosphate", "d": []}, {"i": "EC:4.2.3.38", "l": "\"alpha-bisabolene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49343", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin <=> 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093332", "l": "p-EPHB phosphorylates SDC2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28660", "l": "beta-lactose + H2O => beta-D-galactose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65013", "l": "decanoyl-AMP + holo-[ACP] => AMP + decanoyl-[ACP] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350769", "l": "trans-Golgi Network Coat Activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004978", "l": "corticotropin receptor activity", "d": ["Combining with corticotropin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70369", "l": "CoA + H(+) + N-octanoyl-3-oxosphinganine => 3-oxosphinganine + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25742", "l": "N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202164", "l": "Translocation of PDK1 to Plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63474", "l": "ADP + all-trans-hexaprenyl phosphate + H(+) => all-trans-hexaprenol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38101", "l": "a ribonucleoside 5'-diphosphate + phytyl diphosphate => a ribonucleoside 5'-triphosphate + phytyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350444", "l": "ROK phosphorylates SQH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052603", "l": "1-chloro-4-nitrosobenzene nitroreductase activity", "d": ["Catalysis of the reaction: 1-chloro-4-nitrosobenzene + NADPH + H+ = 1-chloro-4-hydroxylaminobenzene + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662653", "l": "MT4 binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45460", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332236", "l": "CBL neddylates TGFBR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174624", "l": "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14564", "l": "(E,E)-piperoyl-CoA + piperidine <=> CoA + H(+) + piperine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19316", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392752", "l": "Phosphorylation of L1 by CK-II (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74674", "l": "UDP-beta-L-arabinopyranose(in) + UMP(out) <=> UDP-beta-L-arabinopyranose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445064", "l": "Activation of Rac1 by VAV2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043884", "l": "CO-methylating acetyl-CoA synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33032", "l": "H(+) + keto-D-fructose + NADH => D-sorbitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32802", "l": "urea(in) <=> urea(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58366", "l": "a medium-chain fatty aldehyde + H(+) + NADPH => a medium-chain primary fatty alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59038", "l": "4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71974", "l": "3-hydroxyglutarate(out) + 3 Na(+)(out) <=> 3-hydroxyglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202714", "l": "CD58 binds CD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008877", "l": "glucose-1-phosphatase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912393", "l": "MAML in complex with NICD1 recruits CDK8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788611", "l": "HYKK phosphorylates 5HLYS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070260", "l": "5'-tyrosyl-DNA phosphodiesterase activity", "d": ["Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19571", "l": "5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => 5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61611", "l": "[DsbB protein]-dithiol + a quinone <=> [DsbB protein]-disulfide + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63231", "l": "ATP + spectinomycin <=> 9-O-adenylylspectinomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53094", "l": "2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine => 2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033839", "l": "flavonol-3-O-glycoside glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33142", "l": "L-alanine(out) + L-aspartate(in) <=> L-alanine(in) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31046", "l": "(S)-methylmalonate semialdehyde + H2O + NAD(+) <=> 2 H(+) + methylmalonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46257", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23675", "l": "a quinone + L-quinate <=> 3-dehydroquinate + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55341", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol => 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110215", "l": "Cleavage of uracil by UNG glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72653", "l": "1,6-dihydroxyphenazine N(5),N(10)-dioxide + H2O + NADP(+) => 1,6-dihydroxyphenazine N(5)-oxide + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20731", "l": "H2O + L-glutamate + O2 <=> 2-oxoglutarate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65900", "l": "3-hydroxy-L-kynurenine + glyoxylate = glycine + H2O + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786155", "l": "POLN binds ICL-DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29554", "l": "H2O + UDP-alpha-D-glucose <=> alpha-D-galactose 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25074", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O", "d": []}, {"i": "EC:4.2.1.92", "l": "\"hydroperoxide dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11659", "l": "ATP + holo-[peptidyl-carrier protein] + L-proline <=> AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65806", "l": "a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+) + L-tyrosine => a 5'-end L-tyrosylphosphate-2'-deoxynucleoside-DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050440", "l": "2-methylcitrate synthase activity", "d": ["Catalysis of the reaction: H2O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40841", "l": "(2E)-nonenoyl-CoA + FADH2 => FAD + H(+) + nonanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20001", "l": "glycolaldehyde + H2O + NAD(+) = glycolate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.21", "l": "\"glycolaldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981658", "l": "Complement factor I binds C4BP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75527", "l": "(R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMNH2 + O2 = benzaldehyde + FMN + H(+) + H2O + N-acetyl-S-hydroxy-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193702", "l": "Part of the ICD migrates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665761", "l": "FMNL3 binds RHOC:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009979", "l": "16:0 monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the introduction of an omega-3 double bond into an unsaturated 16-carbon fatty acid in a monogalactosyldiacylglycerol molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9716947", "l": "ESR1 binds ESR1 agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444527", "l": "FPR is a receptor for formyl peptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791167", "l": "Expression of SERP1 (RAMP4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624951", "l": "TNPO1 binds KIF17 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12223", "l": "H2O + L-leucine + NAD(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047095", "l": "2-hydroxycyclohexanone 2-monooxygenase activity", "d": ["Catalysis of the reaction: 2-hydroxycyclohexan-1-one + NADPH + O2 = 6-oxohexanoate + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25317", "l": "L-2-acetamido-6-oxoheptanedioate + L-glutamate => 2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483219", "l": "PC is exchanged with PI by PITPNB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76052", "l": "Binding of TFIIIA To type 1 Promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050480", "l": "imidazolonepropionase activity", "d": ["Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H2O = N-formimidoyl-L-glutamate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6805811", "l": "Release of SEPT4 from mitochondria (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029456", "l": "RAC1 and CDC42 activate PAK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177926", "l": "Dephosphorylation of PAG by SHP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16719", "l": "cholate + FADH2 => deoxycholate + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35109", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+) => 3-nitrotyramine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30175", "l": "15-cis-phytoene + 2 plastoquinone-9 = 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1912357", "l": "ITCH ubiquitinates DTX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21822", "l": "H(+) + L-methionine + S-adenosyl-L-homocysteine => L-homocysteine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240783", "l": "E2F1/2/3 stimulates EZH2 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035485", "l": "adenine/guanine mispair binding", "d": ["Binding to a double-stranded DNA region containing an A/G mispair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451311", "l": "Activation of Ca-permeable Kainate receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709179", "l": "DPP4 binds DPP4 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-179417", "l": "Multiubiquitination of Nek2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204871", "l": "Interaction of Tie2 and Grb2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56930", "l": "abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004989", "l": "octopamine receptor activity", "d": ["Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936380", "l": "Interaction of PIN1 with p-IRF3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198508", "l": "MDH1 oxidizes MAL to OA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34231", "l": "5-nitrosalicylate + O2 = 4-nitro-6-oxohepta-2,4-dienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102250", "l": "linear malto-oligosaccharide phosphorylase activity", "d": ["Catalysis of the reaction: hydrogenphosphate + a linear malto-oligosaccharide = alpha-D-glucose 1-phosphate + a linear malto-oligosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17634", "l": "a beta-D-glucuronoside + H2O => an alcohol + D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27606", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}, {"i": "EC:2.7.8.29", "l": "\"L-serine-phosphatidylethanolamine phosphatidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989760", "l": "Expression of HMGCS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635854", "l": "GLI2,3 are degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0004129", "l": "cytochrome-c oxidase activity", "d": ["Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50337", "l": "O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate => H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112385", "l": "Addition of nucleotides leads to transcript elongation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13906", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43933", "l": "3beta-hydroxyandrost-5-en-17-one + NAD(+) => androst-5-ene-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0009038", "l": "undecaprenol kinase activity", "d": ["Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate."]}, {"i": "EC:2.7.1.66", "l": "\"undecaprenol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2484822", "l": "Kinetochore assembly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23620", "l": "ATP + N(2)-(2-carboxyethyl)-L-arginine = AMP + deoxyamidinoproclavaminate + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.3.4", "l": "\"(carboxyethyl)arginine beta-lactam-synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75082", "l": "24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-hydroxy-24,25-dihydrolanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11223", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30103", "l": "2,5-didehydro-D-gluconate + H(+) + NADH = 5-dehydro-D-gluconate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849435", "l": "PTPN1 dephosphorylates PTK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202726", "l": "F11R dimerises (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61072", "l": "(-)-(R)-19-hydroxytabersonine + acetyl-CoA = (-)-(R)-19-O-acetyltabersonine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23777", "l": "ATP + L-aspartate => 4-phospho-L-aspartate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879222", "l": "MDP:NLRP1 binds ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22517", "l": "ATP + taurocyamine => ADP + H(+) + N-phosphotaurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71663", "l": "a menaquinone + 2 H(+)(out) + succinate = a menaquinol + fumarate + 2 H(+)(in)", "d": []}, {"i": "EC:7.1.1.12", "l": "\"succinate dehydrogenase (electrogenic, proton-motive force generating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202724", "l": "P-selectin binds P-selectin ligand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693536", "l": "ATM phosphorylates MDC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54230", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine => 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507869", "l": "Aquaporins passively transport glycerol into cells (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944246", "l": "Association of procollagen type XXI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045134", "l": "UDP phosphatase activity", "d": ["Catalysis of the reaction: UDP + H2O = UMP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877902", "l": "Activated AR binds RUNX2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31620", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose => dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45359", "l": "H2O + N-(11Z-eicosenoyl)-sphing-4-enine <=> (11Z)-eicosenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51754", "l": "a 2-acyl-4-prenylphloroglucinol + diphosphate => a 2-acylphloroglucinol + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26434", "l": "indole + L-serine = H2O + L-tryptophan", "d": []}, {"i": "EC:4.2.1.122", "l": "\"tryptophan synthase (indole-salvaging)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029460", "l": "PAK1 phosphorylates LIMK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018801", "l": "glutaconyl-CoA decarboxylase activity", "d": ["Catalysis of the reaction: trans-glutaconyl-CoA + H+ = but-2-enoyl-CoA + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37345", "l": "adenosine + phosphate => adenosine 2'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948569", "l": "miR-19b microRNA binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32459", "l": "2 S-adenosyl-L-methionine + uroporphyrinogen III = H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.107", "l": "\"uroporphyrinogen-III C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47566", "l": "ganglioside GA2 (d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29657", "l": "L-cysteine(out) => L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49007", "l": "aurachin C + H(+) + NADPH + O2 <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097253", "l": "beta-hydroxybutyrate transmembrane transporter activity", "d": ["Enables the transfer of beta-hydroxybutyrate from one side of a membrane to the other. Beta-hydroxybutyrate is the conjugate base of (R)-3-hydroxybutyric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11713", "l": "3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49127", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate <=> H2O + NADP(+) + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.67", "l": "\"11-hydroxysugiol 20-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54789", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide => [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46680", "l": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+)", "d": []}, {"i": "EC:1.6.2.2", "l": "\"cytochrome-b5 reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034915", "l": "2-methylhexanoyl-CoA C-acetyltransferase activity", "d": ["Catalysis of the reaction: 4-methyl-3-oxooctanoyl-CoA + CoA = acetyl-CoA + 2-methylhexanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38338", "l": "(20S)-ginsenoside Rb1 + 2 H2O <=> (20S)-ginsenoside Rg3 + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71305", "l": "chloride(in) + L-methionine(in) + 2 Na(+)(in) => chloride(out) + L-methionine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029454", "l": "Autophosphorylation of PAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20887", "l": "H2O + L-serine + NAD(+) <=> 3-hydroxypyruvate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-984606", "l": "Kinesin-5 is a homotetramer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652099", "l": "Defective SLC35A2 does not exchange UDP-Gal, UDP-GalNAc for UMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44016", "l": "2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) = 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66283", "l": "solanidine + UDP-alpha-D-glucose <=> H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52912", "l": "3-dimethylallyl-4-hydroxymandelate + O2 = 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O", "d": []}, {"i": "EC:1.13.12.23", "l": "\"4-hydroxy-3-prenylbenzoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58549", "l": "2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71425", "l": "3,3',5-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out) => 3,3',5-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71675", "l": "glycyl-L-leucine(out) + H(+)(out) = glycyl-L-leucine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34634", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48745", "l": "(-)-yatein + 2-oxoglutarate + O2 => (-)-deoxypodophyllotoxin + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64543", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44219", "l": "12-hydroxyoctadecanoate + ATP + CoA <=> 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662986", "l": "MT2A binds copper (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27791", "l": "2-all-trans-octaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24208", "l": "1,5-anhydro-D-mannitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.292", "l": "\"1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707586", "l": "FeHM oxidises LDL,HDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43880", "l": "(25S)-3beta-hydroxy-5-cholestenoate + ATP + CoA = (25S)-3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8863727", "l": "STON2 is neddylated (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60799", "l": "2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2 <=> 3 CO2 + gibberellin A20 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32638", "l": "linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16445", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone = daidzein + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.9.-", "l": "\"With a copper protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24410", "l": "inosine + NH4(+) => adenosine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51461", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamate => (9Z)-octadecenoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62425", "l": "(E)-caffeoyl-CoA + H2O => 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17293", "l": "2 H(+) + NADH + O2 + precorrin-3A = H2O + NAD(+) + precorrin-3B", "d": []}, {"i": "EC:1.14.13.83", "l": "\"precorrin-3B synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70664", "l": "4-hydroxy-L-proline(in) + H(+)(in) => 4-hydroxy-L-proline(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47088", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353484", "l": "Uracil glycosylase mediated recognition and binding of uracil opposite guanine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75138", "l": "NADP(+) + neopine <=> H(+) + NADPH + neopinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66480", "l": "gypsogenin + UDP-alpha-D-glucose = gypsogenin 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "60.482821972649937", "identifiers": [{"i": "GO:0042578", "l": "phosphoric ester hydrolase activity", "d": ["Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3."]}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0140824", "l": "thioredoxin-dependent peroxiredoxin activity", "d": ["Catalysis of the reaction: [thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55109", "l": "3-oxononanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxynonanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67794", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA => ribonucleotidyl-uridine-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10620", "l": "(E)-cinnamaldehyde + CoA + NADP(+) = (E)-cinnamoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41971", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) <=> a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20029", "l": "10-deoxysarpagine + NADP(+) = H(+) + NADPH + vellosimine", "d": []}, {"i": "EC:1.1.1.273", "l": "\"vellosimine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38421", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate => 1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106156", "l": "peptidyl-lysine 4-dioxygenase activity", "d": ["Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 4-hydroxy-L-lysine + succinate + CO2."]}, {"i": "RHEA:57156", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 = 4-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0031701", "l": "angiotensin receptor binding", "d": ["Binding to an angiotensin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432909", "l": "Interaction of Plectin with Integrin beta 4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47835", "l": "ganglioside GD1a + H2O <=> ganglioside GM1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53781", "l": "beta-muricholate + lithocholoyl-CoA => beta-muricholoyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61246", "l": "H2O2 + indole-3-pyruvate + NH4(+) => H2O + L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18408", "l": "H2O + L-alanine + NAD(+) <=> H(+) + NADH + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165680", "l": "Formation of active mTORC1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0043028", "l": "cysteine-type endopeptidase regulator activity involved in apoptotic process", "d": ["Binds to and modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58874", "l": "4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 24-methylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004677", "l": "DNA-dependent protein kinase activity", "d": ["DNA dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382053", "l": "Translocation of PDGF from ER to Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49956", "l": "5,10-dihydrophenazine 1-carboxylate + O2 = H2O2 + phenazine-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997237", "l": "SH2B proteins bind JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52781", "l": "H2O + S-(hercyn-2-yl)-L-cysteine S-oxide => 2-sulfenohercynine + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15122", "l": "dithioerythritol + thiosulfate => cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75862", "l": "Fall Back to Closed Pre-initiation Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66528", "l": "ATP + O-(5'-adenylyl)-L-tyrosyl-[protein] = diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55805", "l": "(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O => (9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43376", "l": "5'-deoxyinosine + phosphate = 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203973", "l": "Vesicle budding (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901047", "l": "Binding of ERp57 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655170", "l": "RCHY1 monoubiquitinates POLH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691150", "l": "TFR2 dimer binds 2xholoTF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57363", "l": "H2O + NADH <=> (6R)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15917", "l": "an aldopyranose + NAD(+) = aldono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676254", "l": "Formation of the MLL3 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109342", "l": "Trans,cis-lauro-2,6-dienoyl-CoA is converted to cis,cis-3,6- 4-cis-decenoyl-CoA by one cycle of beta-oxidation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20114", "l": "beta-D-glucose 1-phosphate => beta-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51416", "l": "a (2S,3R)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047720", "l": "indoleacetaldoxime dehydratase activity", "d": ["Catalysis of the reaction: (indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59352", "l": "beta-lactose + O2 = H2O2 + lactobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140761", "l": "sequestered tissue factor -> tissue factor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694421", "l": "PP6 dephosphorylates SEC24 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2219536", "l": "AKT1 E17K mutant binds PIP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36870", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202510", "l": "Activation of TAK1-TAB2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36633", "l": "(2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+) => D-ribulose 1,5-bisphosphate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11752", "l": "acetylsalicylate + H2O = acetate + H(+) + salicylate", "d": []}, {"i": "EC:3.1.1.55", "l": "\"acetylsalicylate deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696266", "l": "RND2 binds effectors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692809", "l": "CDC42 binds effectors at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018565", "l": "dihydroxydibenzothiophene dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxydibenzothiophene + O2 = cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015414", "l": "ABC-type nitrate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nitrate(out) = ADP + phosphate + nitrate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27633", "l": "ethylene glycol + NAD(+) <=> glycolaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9733292", "l": "AMY1-3 bind pramlintide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632674", "l": "ADRBK1 binds phosphorylated SMO dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38363", "l": "1-octadecanoylglycerol + H2O = glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451466", "l": "TRAF6 binding to activated IRAK2 stimulates its oligomerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10661", "l": "L-seryl-[protein] => D-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55889", "l": "[aequorin]--dioxetanone => [excited state blue fluorescent protein] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388833", "l": "Phosphorylation of CTLA-4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42220", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate = 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59448", "l": "dodecan-1-ol + NADP(+) = dodecanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9611851", "l": "ADRB2 bind ADR,NAd (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61443", "l": "acetyl-CoA + S-(2-succino)-L-cysteine <=> CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13883", "l": "a carboxylate + a quinol + H(+) => a quinone + an aldehyde + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29797", "l": "ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in) => ATP(in) + H2O(in) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47926", "l": "(2S)-3-sulfolactaldehyde + pyruvate => 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25644", "l": "(1R,4S)-menthone + NADP(+) <=> (R)-pulegone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66340", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15588", "l": "15-cis-phytoene + 4 A <=> 4 AH2 + all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19108", "l": "4-aminobutanal + H2O + NAD(+) <=> 4-aminobutanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40589", "l": "CoA + H(+) + octanedioate => H2O + octanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54489", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61325", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900765", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3221982", "l": "BANP binds TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848414", "l": "Activated PTK6 binds CDKN1B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16579", "l": "P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate => ADP + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25199", "l": "5-amino-6-(D-ribitylamino)uracil + phosphate => 5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693575", "l": "DNA-PKcs autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17827", "l": "ADP + D-glucose 6-phosphate + H(+) => ATP + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130706", "l": "MHC class II antigen processing (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42688", "l": "AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide = A + ergothioneine + NH4(+) + pyruvate", "d": []}, {"i": "EC:4.4.1.36", "l": "\"hercynylcysteine S-oxide lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12218", "l": "9H-fluoren-9-one + H(+) + NADH => 9H-fluoren-9-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31287", "l": "H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA = acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14421", "l": "H2O + N(2)-benzoyl-D-arginine-4-nitroanilide = 4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine", "d": []}, {"i": "EC:3.5.1.72", "l": "\"D-benzoylarginine-4-nitroanilide amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981657", "l": "IL34 dimer binds PTPRZ1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050558", "l": "maltose epimerase activity", "d": ["Catalysis of the reaction: alpha-maltose = beta-maltose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29077", "l": "CO2(out) + H(+)(out) + ubiquinol-8 => formate(out) + 2 H(+)(in) + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62715", "l": "betaenone C + H(+) + NADPH + O2 <=> H2O + NADP(+) + stemphyloxin I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15390", "l": "ATP => 3',5'-cyclic AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015408", "l": "ABC-type ferric iron transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001604", "l": "urotensin II receptor activity", "d": ["Combining with urotensin II to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38153", "l": "CO2 + H(+) + hydrogen sulfide => carbonyl sulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37179", "l": "(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate = (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24146", "l": "3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O => 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66700", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672969", "l": "Phosphorylation of RAF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17637", "l": "squalene = hop-22(29)-ene", "d": []}, {"i": "EC:5.4.99.17", "l": "\"squalene--hopene cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54898", "l": "(10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate => (9S,13S,15Z)-12-oxophyto-10-15-dienoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9006870", "l": "IL21 receptor STAT phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36473", "l": "3,4,5-trihydroxybenzoate(in) + H(+)(in) => 3,4,5-trihydroxybenzoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51387", "l": "hexadecanoyl-CoA + serotonin <=> CoA + H(+) + N-hexadecanoyl-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210773", "l": "PDX1-dependent synthesis of NR5A2 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190788", "l": "Formation of junctional channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29369", "l": "cytidine + phosphate => CMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687465", "l": "MRN complex binds RBBP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61134", "l": "CO2 + H(+) + H2O + kaempferol + succinate => (2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74350", "l": "O-acyl-(R)-carnitine(in) <=> O-acyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.387", "l": "\"isomaltosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61688", "l": "ATP + holo-[peptidyl-carrier protein] + L-threonine = AMP + diphosphate + L-threonyl-[peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.70", "l": "\"L-threonine--[L-threonyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39396", "l": "3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74124", "l": "pelargonidin + UDP-alpha-D-galactose => pelargonidin 3-O-beta-D-galactoside betaine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043879", "l": "glycolate transmembrane transporter activity", "d": ["Enables the transfer of glycolate from one side of a membrane to the other. Glycolate is the smallest alpha-hydroxy acid (AHA)."]}, {"i": "RHEA:29447", "l": "glycolate(in) = glycolate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17518", "l": "H2O + N-(long-chain-fatty-acyl)-L-glutamate => a long-chain fatty acid + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694462", "l": "ABHD6,12 hydrolyse 3AG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22149", "l": "a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] => a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42499", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate <=> 10-deacetyl-2-debenzoylbaccatin III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193068", "l": "CYP17A1 17-hydroxylates PREG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.9", "l": "\"NADH:ubiquinone reductase (non-electrogenic)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709878", "l": "BIL translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045480", "l": "galactose oxidase activity", "d": ["Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446391", "l": "Formation of the PINCH-ILK-parvin complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047683", "l": "aryl-aldehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: an aromatic aldehyde + NADP+ + AMP + diphosphate + H2O = an aromatic acid + NADPH + ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38680", "l": "ATP + H2O + sphinganine(in) => ADP + H(+) + phosphate + sphinganine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13059", "l": "an N-acylneuraminate + phosphate => an N-acylneuraminate 9-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39753", "l": "11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25906", "l": "dehypoxanthine futalosine + hypoxanthine => futalosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052755", "l": "reduced coenzyme F420:quinone oxidoreductase activity", "d": ["Catalysis of the reaction: reduced coenzyme F420 + 2,3-dimethyl-1,4-naphthoquinone = coenzyme F420 + reduced 2,3-dimethyl-1,4-naphthoquinone. Reduced 2,3-dimethyl-1,4-naphthoquinone is also known as 2,3-dimethyl-1,4-hydronaphthoquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654422", "l": "Activated FGFR4 binds FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32164", "l": "ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine => AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770131", "l": "Formation of the Spliceosomal B* complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879222", "l": "MDP:NLRP1 binds ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38347", "l": "(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate", "d": []}, {"i": "EC:2.6.1.103", "l": "\"(S)-3,5-dihydroxyphenylglycine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45657", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29296", "l": "aldehydo-D-galacturonate(out) + H(+)(out) => aldehydo-D-galacturonate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53655", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47477", "l": "(3E)-tetradecenoyl-CoA => (2E)-tetradecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561072", "l": "OCT3 mediates renal uptake of organic cations (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46468", "l": "an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O = ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31814", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + viridiflorene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23401", "l": "7,8-dihydroxykynurenate + O2 => 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034927", "l": "pyrene 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-1,2-oxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43234", "l": "H(+) + isatinate => H2O + isatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68480", "l": "(2R)-2-hydroperoxyhexadecanoate + H(+) = CO2 + H2O + pentadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110319", "l": "Elongation by POLH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804253", "l": "MDM2 ubiquitinates JMY (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13911", "l": "alpha-D-ribose 1-phosphate + urate => phosphate + urate D-ribonucleoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-184392", "l": "N-myristoylation of GAG polyprotein by NMT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67049", "l": "AH2 + chermesin D + O2 => A + asnovolin I + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46733", "l": "(2R,6)-dimethylheptanoyl-CoA => (2S,6)-dimethylheptanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68912", "l": "ATP + H(+) + NADPH + propanoate = AMP + diphosphate + NADP(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951486", "l": "CD46 binds C4b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17437", "l": "2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate = (2E,4E)-2,4-dichloromuconate + H(+)", "d": []}, {"i": "EC:5.5.1.11", "l": "\"dichloromuconate cycloisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35445", "l": "an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP => an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43307", "l": "3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer <=> 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73240", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether => H(+) + ladanein + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070410", "l": "co-SMAD binding", "d": ["Binding to a common mediator SMAD signaling protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031925", "l": "pyridoxal transmembrane transporter activity", "d": ["Enables the transfer of pyridoxal from one side of a membrane to the other. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371353", "l": "Soluble TNF-α binds TNFR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940100", "l": "CDK1 phosphorylates VCPIP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29993", "l": "H(+)(out) + L-lyxopyranose(out) => H(+)(in) + L-lyxopyranose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19809", "l": "(S)-ureidoglycolate + 2 H(+) + H2O = CO2 + glyoxylate + 2 NH4(+)", "d": []}, {"i": "EC:3.5.1.116", "l": "\"ureidoglycolate amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32398", "l": "(1S,2S,4S)-dihydrocarveol + NAD(+) <=> (1S,4S)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76060", "l": "heliamine + S-adenosyl-L-methionine => H(+) + N-methylheliamine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56540", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol = 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38953", "l": "ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out) => ATP + H2O + sphing-4-enine 1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72983", "l": "dimethylallyl diphosphate + harmol = 6-(3-dimethylallyl)harmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047253", "l": "alpha-1,6-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-B-glucosaminyl-1,2)-beta-D-mannosyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-1,2-beta)-(N-acetyl-D-glucosaminyl-1,4-beta)-D-mannosyl-R + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13959", "l": "6 H(+) + 2 hydrogen sulfide + 2 sulfite => 4 H2O + O2 + 4 sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15139", "l": "H(+) + keto-L-tagatose 6-phosphate + NADH => galactitol 1-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56364", "l": "13-dihydrocarminomycin + H(+) + NADPH + O2 = carminomycin + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9726621", "l": "PGR binds PGR antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42366", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 a 2-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41720", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17465", "l": "H2O + quercitrin = L-rhamnopyranose + quercetin", "d": []}, {"i": "EC:3.2.1.40", "l": "\"alpha-L-rhamnosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51316", "l": "(9Z)-octadecenoate + glycine = H2O + N-(9Z-octadecenoyl)glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11963", "l": "2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate <=> (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080074", "l": "spermidine:caffeoyl CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of a caffeoyl group to a nitrogen atom on the spermidine molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112429", "l": "Formation of FACT complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029456", "l": "RAC1 and CDC42 activate PAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40569", "l": "A + dTDP-beta-L-evernitrose + H2O => AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34657", "l": "3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine => C30 botryococcene + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5444523", "l": "Formation of MSH1:PMS2 Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18564", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244424", "l": "botA:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68600", "l": "(2S)-3-sulfopropanediol = 3-oxopropane-1-sulfonate + H2O", "d": []}, {"i": "EC:4.2.1.177", "l": "\"(2S)-3-sulfopropanediol dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23151", "l": "ATP + propanoate <=> ADP + propanoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55217", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + rhizathalene A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102449", "l": "kaempferol 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: kaempferol oxoanion + S-adenosyl-L-methionine <=> 3-O-methylkaempferol + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12522", "l": "(E)-caffeate + NH4(+) => L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20007", "l": "an alcohol + D-glucuronate => an alpha-D-glucuronoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62741", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) => 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37480", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047163", "l": "3,4-dichloroaniline N-malonyltransferase activity", "d": ["Catalysis of the reaction: 3,4-dichloroaniline + malonyl-CoA = N-(3,4-dichlorophenyl)malonamate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696670", "l": "CHD1L is recruited to GG-NER site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73769", "l": "diphosphate + preechinulin => cyclo(L-tryptophyl-L-alanyl) + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1638845", "l": "CERK phosphorylates CERA to form C1P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209358", "l": "Phosphorylated AP-1, Phospho JRA:Phospho KAY binds to a target gene and activates transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17101", "l": "H2O + O-acyl-(R)-carnitine = (R)-carnitine + a fatty acid + H(+)", "d": []}, {"i": "EC:3.1.1.28", "l": "\"acylcarnitine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0009035", "l": "type I site-specific deoxyribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions, driven by ATP hydrolysis. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31443", "l": "ATP + D-sedoheptulose 7-phosphate = ADP + D-sedoheptulose 1,7-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981355", "l": "RASA1 binds RAS:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65147", "l": "2-oxoglutarate + berkeleyone A + O2 <=> CO2 + H2O + preaustinoid A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69056", "l": "H(+) + N(omega)-methyl-L-arginine + NADH + O2 = H2O + N(delta)-hydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013147", "l": "RAC1 GDIs block activation of RAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5096532", "l": "Defective GALNT12 does not transfer GalNAc to mucins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004941", "l": "beta2-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35717", "l": "(2S-3S)-versiconal hemiacetal + acetate + H(+) => (2S,3S)-versiconal hemiacetal acetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74142", "l": "petunidin + UDP-alpha-D-glucose <=> petunidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62503", "l": "holo-[peptidyl-carrier protein] + L-arginyl-AMP <=> AMP + H(+) + L-arginyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018685", "l": "alkane 1-monooxygenase activity", "d": ["Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73487", "l": "a carboxylate(in) + orotate(out) = a carboxylate(out) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41404", "l": "(R)-2-methylpyrrolidine + NADP(+) = 2-methyl-1-pyrroline + H(+) + NADPH", "d": []}, {"i": "EC:1.5.1.48", "l": "\"2-methyl-1-pyrroline reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047277", "l": "globoside alpha-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31928", "l": "3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49871", "l": "(+)-dehydrodiconiferyl acid + a quinone <=> (+)-dehydrodiconiferyl acid ketone + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11866", "l": "dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein] => H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65240", "l": "(11Z)-octadecenoyl-CoA + H2O = (11Z)-octadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66439", "l": "NADP(+) + pentan-3-one <=> H(+) + NADPH + pent-1-en-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56744", "l": "2-oxoglutarate + L-arginyl-[protein] + O2 = (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.73", "l": "\"[protein]-arginine 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49508", "l": "phosphinomethylmalate = 2-(phosphinatomethylidene)butanedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730842", "l": "PI3K associates with phosphorylated GAB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59561", "l": "H2O + N,N',N''-triacetylchitotriono-1,5-lactone => H(+) + N,N',N''-triacetylchitotrionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433418", "l": "Phosphorylation of JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18324", "l": "2-oxoglutarate + L-leucine <=> 4-methyl-2-oxopentanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0015091", "l": "ferric iron transmembrane transporter activity", "d": ["Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019119", "l": "phenanthrene-9,10-epoxide hydrolase activity", "d": ["Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59683", "l": "D-maltopentaose + O2 <=> D-maltopentaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055077", "l": "gap junction hemi-channel activity", "d": ["A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693761", "l": "FA2H hydroxylates CERA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65597", "l": "4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] => 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58937", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH => all-trans-lycopaoctaene + 2 diphosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20412", "l": "alpha-D-glucose 1-phosphate + riboflavin <=> D-glucose + FMN", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106358", "l": "glycerol-1-phosphate dehydrogenase [NADP+] activity", "d": ["Catalysis of the reaction: NADP+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADPH."]}, {"i": "RHEA:21416", "l": "NADP(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27279", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11199", "l": "5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide <=> alpha-ribazole 5'-phosphate + H(+) + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102393", "l": "decanoyl-[acp] 2-dehydrogenase activity", "d": ["Catalysis of the reaction: FAD + H+ + a decanoyl-HmqF protein = FADH2(2-) + a 2,3-dehydro-decanoyl-HmqF."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690494", "l": "RHOB translocates to the endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.103", "l": "\"teichoic acid D-alanine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374681", "l": "L1 and NCAM1 engaged in cis-interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851919", "l": "Activated MET binds GAB1 and GRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72691", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9770131", "l": "Formation of the Spliceosomal B* complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14330", "l": "2-oxoglutarate + O-phospho-L-serine => 3-phosphooxypyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39309", "l": "(11Z,14Z)-eicosadienoyl-CoA + NADP(+) => (2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210300", "l": "Interaction of DAP12 and TREM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75850", "l": "Addition of the third nucleotide on the nascent transcript (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033894", "l": "ribonuclease P4 activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA, removing 3'-extranucleotides from tRNA precursor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757954", "l": "N4BP1 binds IKBKG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28916", "l": "4-aminobutanoate(in) + H(+)(in) => 4-aminobutanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61764", "l": "stevioside + UDP-alpha-D-glucose = H(+) + rebaudioside E + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.147", "l": "\"16alpha-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75354", "l": "2 Fe(III)-[cytochrome c] + H2O + pseudooxynicotine <=> 4-oxo-4-(pyridin-3-yl)butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661432", "l": "BIL binds ALB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21590", "l": "H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH => N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34019", "l": "a 1-acylglycerol + H2O = a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9716913", "l": "ESR1 binds ESR1 antagonists (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44427", "l": "a fatty acyl-CoA + heptadecasphing-4-enine <=> CoA + H(+) + N-acyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66959", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33695", "l": "C20 sphinganine + NADP(+) = 3-oxoeicosasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018632", "l": "4-nitrophenol 4-monooxygenase activity", "d": ["Catalysis of the reaction: p-nitrophenol + O2 + NADPH = H2O + NADP+ + nitrite + p-benzoquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432946", "l": "PARVB/Affixin interacts with alpha PIX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32435", "l": "dihydrocarvone + H(+) + NADPH + O2 = 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351207", "l": "Spermine  => N-acetylated spermine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49583", "l": "(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate <=> cyclic pyranopterin phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31651", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15461", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62049", "l": "an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-996755", "l": "ZFPM proteins bind GATA proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432295", "l": "GPVI binds Fyn and Lyn (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031694", "l": "alpha-2A adrenergic receptor binding", "d": ["Binding to an alpha-2A adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52114", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164832", "l": "ATPase synthesizes ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72591", "l": "D-glucuronate(out) + H(+)(out) = D-glucuronate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21824", "l": "2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate", "d": []}, {"i": "EC:2.6.1.1", "l": "\"aspartate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198756", "l": "ERK1/2 phosphorylates MSK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12154", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+) => (3R,4S,5S,6R)-pentachlorocyclohexene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12811", "l": "2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O => 4 catechol + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64296", "l": "(4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH = (4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177284", "l": "PKA phosphorylates PDE4B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873830", "l": "STARD7 transports PC from ER membrane to mitochondrial outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40780", "l": "2-aminopentanenitrile + H(+) + 2 H2O => L-2-aminopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.2", "l": "\"lysoplasmalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43181", "l": "cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56258", "l": "H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33543", "l": "ergosteryl palmitate + H2O = ergosterol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30893", "l": "acetate + H(+) + S-sulfo-L-cysteine => O-acetyl-L-serine + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684032", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14467", "l": "L-histidinol + phosphate => H2O + L-histidinol phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74790", "l": "L-histidyl-L-proline diketopiperazine(in) <=> L-histidyl-L-proline diketopiperazine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034958", "l": "aminohydroquinone monooxygenase activity", "d": ["Catalysis of the reaction: aminohydroquinone + 2 e- + 2 H+ + 1/2 O2 = 1,2,4-benzenetriol + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56726", "l": "4-hydroxy-all-trans-beta-carotene + A + H2O => AH2 + all-trans-beta-carotene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-976768", "l": "Factor H binds to C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045028", "l": "G protein-coupled purinergic nucleotide receptor activity", "d": ["Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190258", "l": "FGFR2c binds to FGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25939", "l": "8-methylquinoline + A + H2O <=> 8-methylquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75896", "l": "holothin + marinoloyl-CoA C => CoA + thiomarinol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49817", "l": "3 Fe(III)-[cytochrome c] + H2O + hydrazine => 3 Fe(II)-[cytochrome c] + 2 H(+) + NH4(+) + nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692539", "l": "HRH1 binds HRH1 inverse agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57422", "l": "H(+) + NAD(+) + 2 reduced [cytochrome P450] => NADH + 2 oxidized [cytochrome P450]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042944", "l": "D-alanine transmembrane transporter activity", "d": ["Enables the transfer of D-alanine from one side of a membrane to the other. D-alanine is the D-enantiomer of 2-aminopropanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018798", "l": "RHOV binds GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70982", "l": "Fumarate + H2O <=> (S)-Malate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55081", "l": "ADP-alpha-D-glucose + D-fructose => ADP + H(+) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41970", "l": "a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688459", "l": "RIPK3 binds HSP90:CDC37 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48120", "l": "ganglioside GD3 + H2O = ganglioside GM3 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013143", "l": "RAC1 GEFs activate RAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71169", "l": "glycine(in) + H(+)(out) + Na(+)(in) => glycine(out) + H(+)(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23095", "l": "H(+) + H2O + hydroxyatrazine <=> ethylamine + N-isopropylammelide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0141003", "l": "histone H2AX kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone variant H2AX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67430", "l": "2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863014", "l": "p25-bound CDK5 phosphorylates CDC25A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10376", "l": "ATP + Cu(2+)(in) + H2O = ADP + Cu(2+)(out) + H(+) + phosphate", "d": []}, {"i": "EC:7.2.2.9", "l": "\"P-type Cu(2+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57072", "l": "3-oxoisoapionate 4-phosphate + H(+) = CO2 + L-erythrulose 1-phosphate", "d": []}, {"i": "EC:4.1.1.121", "l": "\"3-oxoisoapionate-4-phosphate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51137", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 => (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9646468", "l": "mTORC1 binds RHEB:GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167684", "l": "Active PLCG1 dissociates from TrkA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16135", "l": "3-aminopropanal + H2O2 + N(1)-acetylspermidine => H2O + N(1)-acetylspermine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937654", "l": "IL10 positively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29855", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine = D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047675", "l": "arabinonate dehydratase activity", "d": ["Catalysis of the reaction: D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963578", "l": "SHC1 binds phosphorylated ERBB2 heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69289", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate => sulfate + sulforaphane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432295", "l": "GPVI binds Fyn and Lyn (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35745", "l": "2 H2O + NADP(+) + versicolorin A => H(+) + NADPH + O2 + versicolorin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26362", "l": "L-tyrosine + NADPH + S-adenosyl-L-methionine => 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163310", "l": "TFAM binds to mitochondrial promoters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38332", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937728", "l": "SRC phosphorylates RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47183", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) <=> (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034939", "l": "5-hydroxypyrrole-2-carboxylate tautomerase activity", "d": ["Catalysis of the reaction: 5-hydroxypyrrole-2-carboxylate = 5-oxo-4,5-dihydropyrrole-2-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60191", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909718", "l": "Formation of p-STAT1 homodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16523", "l": "NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34329", "l": "1,4-benzoquinone + H2O + NADP(+) + nitrite => 4-nitrophenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51077", "l": "2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate => 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392295", "l": "Gbeta:gamma recruits PI3K gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18480", "l": "2,3-dihydroxybenzoate + O2 <=> 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012073", "l": "Autocatalytic phosphorylation of FGFR3c P250R mutant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31975", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin = 7beta-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874197", "l": "CREB3 translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40979", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64604", "l": "L-seryl-[protein] + UTP = diphosphate + uridylyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46958", "l": "(E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035598", "l": "N6-threonylcarbomyladenosine methylthiotransferase activity", "d": ["Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A)."]}, {"i": "REACT:R-HSA-6786571", "l": "CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050293", "l": "steroid-lactonase activity", "d": ["Catalysis of the reaction: H2O + testololactone = H+ + testolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23371", "l": "H(+) + phenylglyoxylate <=> benzaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875568", "l": "RAPGEF1 activates RAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.9", "l": "\"enteropeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635854", "l": "GLI2,3 are degraded by the proteasome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22715", "l": "adenosylcob(III)inamide phosphate + GTP + H(+) <=> adenosylcob(III)inamide-GDP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33843", "l": "H2O + N-tetracosanoylsphinganine = sphinganine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56809", "l": "ATP + cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] => adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28781", "l": "glycine + glycolaldehyde => 4-hydroxy-L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62314", "l": "H(+) + salicylate 2-O-beta-D-glucoside + UDP => salicylate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.n2", "l": "\"blood group B linear chain alpha-1,3-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27951", "l": "L-phenylalanine(in) => L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67924", "l": "3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate = 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139917", "l": "tBID activates BAX protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106255", "l": "hydroperoxy icosatetraenoate isomerase activity", "d": ["A hydroperoxy icosatetraenoate <=> a hydroxy epoxy icosatrienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21358", "l": "H(+) + L-ribulose + NADH => L-arabinitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1861789", "l": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36570", "l": "GDP-beta-L-colitose + NAD(+) <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60480", "l": "2 UTP = c-di-UMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45831", "l": "(3R)-hydroxyhexanoyl-CoA + NAD(+) <=> 3-oxohexanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202164", "l": "Translocation of PDK1 to Plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949580", "l": "F1Fo ATP synthase dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021609", "l": "ESR-associated SRC autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-435244", "l": "PECAM1 is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39810", "l": "octadecanoate(in) <=> octadecanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25238", "l": "ATP + CDP => ADP + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30680", "l": "D-cellobiose + H2O => beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-481044", "l": "Surface deployment of platelet alpha granule membrane components (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34851", "l": "(3S)-3-hydroxyadipyl-CoA + NAD(+) = 3-oxoadipyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627369", "l": "SEPT4 binds XIAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64177", "l": "H2O + N-(9Z-octadecenoyl)-L-tryptophan => (9Z)-octadecenoate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159796", "l": "Furin cleaves pro-factor IX to factor IX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45560", "l": "L-isoleucine = D-allo-isoleucine", "d": []}, {"i": "EC:5.1.1.21", "l": "\"isoleucine 2-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028819", "l": "VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54741", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928640", "l": "PAKs phosphorylate MLC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034790", "l": "3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity", "d": ["Catalysis of the reaction: (+)-(3S,4R)-cis-3,4-dihydroxy-3,4-dihydrofluorene = 3,4-dihydroxyfluorene + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389354", "l": "Activation of Vav1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57602", "l": "a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61978", "l": "5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin] => glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350651", "l": "Caspase-mediated cleavage of MASK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75953", "l": "CO2 + formaldehyde + neomorphinone + succinate => 2-oxoglutarate + O2 + oripavine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28814", "l": "2,3-dioxo-L-gulonate(in) + Na(+)(in) <=> 2,3-dioxo-L-gulonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30646", "l": "phosphate + S-methyl-5'-thioinosine <=> hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50219", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35060", "l": "chloramphenicol(in) + H(+)(out) => chloramphenicol(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19455", "l": "L-glutamate + pyruvate => 2-oxoglutarate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700168", "l": "Active ALK phosphorylates IRS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52578", "l": "(2E)-hexenoyl-CoA + H(+) + NADH => hexanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1364044", "l": "PRLR:JAK2 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9604308", "l": "NICD4 traffics to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093329", "l": "EFNBs bind SDCBP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65955", "l": "2 a quinone + H(+) + NADH <=> 2 a 1,4-benzosemiquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46766", "l": "a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28392", "l": "N(6)-(D-fructosyl)-L-lysine => N(6)-(D-psicosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56003", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68278", "l": "CoA + O-butanoyl-L-seryl-[protein] => butanoyl-CoA + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16108", "l": "a (3S)-3-hydroxyacyl-CoA <=> a (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047093", "l": "4-hydroxyquinoline 3-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + quinolin-4-ol = H2O + NAD+ + quinoline-3,4-diol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807872", "l": "Active ARF recruits coatomer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72628", "l": "2 H(+)(out) + Zn(2+)(in) => 2 H(+)(in) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44839", "l": "globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose <=> globoside NOR2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74367", "l": "substance P(out) = substance P(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374909", "l": "Metabolism of Noradrenaline (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62829", "l": "GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204364", "l": "ROBO1 binds SLIT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22102", "l": "3,5-dibromo-4-hydroxybenzoate + NH4(+) => 3,5-dibromo-4-hydroxybenzonitrile + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10044", "l": "cyclohexanol + NAD(+) = cyclohexanone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.245", "l": "\"cyclohexanol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20923", "l": "2,4-dichlorophenol + H(+) + NADPH + O2 <=> 3,5-dichlorocatechol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53081", "l": "4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate => 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66155", "l": "acetyl-CoA + noradrenaline <=> CoA + H(+) + N-acetylnoradrenaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669900", "l": "KIT mutants bind type II TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45466", "l": "(5Z)-eicosenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => eicosanoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52438", "l": "2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA => a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20993", "l": "16-hydroxytabersonine + S-adenosyl-L-methionine => 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033825", "l": "oligosaccharide 4-alpha-D-glucosyltransferase activity", "d": ["Catalysis of the transfer of the non-reducing terminal alpha-D-glucose residue from a 1,4-alpha-D-glucan to the 4-position of an alpha-D-glucan, thus bringing about the hydrolysis of oligosaccharides."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050176", "l": "phenylalanine N-acetyltransferase activity", "d": ["Catalysis of the reaction: L-phenylalanine + acetyl-CoA = N-acetyl-L-phenylalanine + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791235", "l": "GADD45A binds AURKA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50593", "l": "13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) => 15-oxoprostaglandin F1alpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029454", "l": "Autophosphorylation of PAK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38707", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56883", "l": "a 3beta-hydroxy-Delta(5)-steroid + NADP(+) <=> a 3-oxo-Delta(5)-steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70271", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72750", "l": "leukotriene E4(out) <=> leukotriene E4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49171", "l": "8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine <=> 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36457", "l": "ADP + H(+) + L-alanylglycine(in) + phosphate => ATP + H2O + L-alanylglycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76012", "l": "(3R)-hydroxybutanoate tetramer + H2O => (3R)-hydroxybutanoate trimer + (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73130", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine <=> 4',8-dihydroxy-7-methoxyflavone + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.144", "l": "\"3-deoxyoctulosonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48157", "l": "ganglioside GQ1b (d18:1(4E)) + H2O => ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9761027", "l": "ZEB2 binds SP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5099899", "l": "WNT5A binds FZD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21853", "l": "(R)-10-hydroxyoctadecanoate => (9Z)-octadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71898", "l": "dGTP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52372", "l": "17beta-estradiol + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603784", "l": "PEX19:class I PMP binds PEX3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433542", "l": "Phosphorylation and activation of VAV1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42162", "l": "(5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52410", "l": "CO2 + dihydroxyacetone phosphate + NADH => 4-phospho-D-erythronate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54395", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852317", "l": "PLK1 phosphorylates GTSE1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420117", "l": "VEGFR2 autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29003", "l": "H(+)(out) + L-homoserine(in) = H(+)(in) + L-homoserine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41004", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39252", "l": "(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH => (11Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0033678", "l": "5'-3' DNA/RNA helicase activity", "d": ["Unwinding of a DNA/RNA duplex in the 5' to 3' direction, driven by ATP hydrolysis."]}, {"i": "REACT:R-HSA-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49472", "l": "trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose = H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP", "d": []}, {"i": "EC:2.4.2.58", "l": "\"hydroxyproline O-arabinosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17178", "l": "(R)-carnitine + octanoyl-CoA => CoA + O-octanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69747", "l": "(indol-3-yl)acetate + succinyl-CoA = (indol-3-yl)acetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15471", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64561", "l": "butan-2-ol + NAD(+) => butan-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634861", "l": "NPAS4 binds ARNT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372529", "l": "Release of acetylcholine at the synapse (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73937", "l": "desmethyl-dehydrogriseofulvin + 2 H2O + oxidized [NADPH--hemoprotein reductase] => griseophenone B + H(+) + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.9.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75425", "l": "(R)-acetoin + H(+) + NADH => (R,S)-butane-2,3-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3095889", "l": "MMACHC dealkylates RCbl (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44629", "l": "L-dihydroanticapsin + NAD(+) => H(+) + L-anticapsin + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31183", "l": "acetyl-CoA + decanoyl-CoA = 3-oxododecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867047", "l": "PTPN3 dephosphorylates EPS15 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032542", "l": "sulfiredoxin activity", "d": ["Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56781", "l": "(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928576", "l": "RHOA:GTP binds ROCK, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59353", "l": "beta-lactose + O2 => H2O2 + lactobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19031", "l": "2 CO2 + 2 NH4(+) => 3 H(+) + H2O + urea-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44643", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + ATP <=> a 2'-deoxyribonucleoside 5'-triphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199112", "l": "CRTAM binds to NECL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15862", "l": "3-ADP-2-phosphoglycerate + H2O => 3-ADP-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0003968", "l": "RNA-dependent RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482772", "l": "Release of platelet cytosolic components (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791084", "l": "Expression of SYVN1 (HRD1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784598", "l": "NPPA(124-151) binds NPR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.102", "l": "\"beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34950", "l": "(Z)-3-aminoacrylate + H(+) + H2O <=> 3-oxopropanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395764", "l": "atREs binds to nascent CM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57584", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.162", "l": "\"flavanone 2-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66449", "l": "(E)-pent-2-en-1-ol + NADP(+) => (E)-2-pentenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68670", "l": "16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58169", "l": "(2E,6E)-farnesyl diphosphate => (-)-5-epi-eremophilene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707516", "l": "FeHM dissociates from MetHb (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798373", "l": "MDM2 ubiquitinates DYRK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23910", "l": "2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine => H(+) + 2 methylcob(III)alamin-[methionine synthase] + NADP(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052760", "l": "coenzyme F420-dependent 2,4-dinitrophenol reductase activity", "d": ["Catalysis of the reaction: 2,4-dinitrophenol + H- = 2,4-dinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013157", "l": "CDC42 binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11747", "l": "H2O + thiamine triphosphate <=> H(+) + phosphate + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64023", "l": "GTP + L-seryl-[protein] <=> GDP + H(+) + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848606", "l": "PTK6 phosphorylates PXN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52850", "l": "5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => 5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031797", "l": "type 2 metabotropic GABA receptor binding", "d": ["Binding to a type 2 metabotropic GABA receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53129", "l": "delta-carotene => epsilon-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000348", "l": "RANBP2 SUMOylates SP100 with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30747", "l": "FAD + H(+) + hexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58207", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine <=> dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61536", "l": "ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50375", "l": "an N-acylsphingoid base 1-phosphate(in) <=> an N-acylsphingoid base 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20788", "l": "NAD(+) + phosphate = ADP-alpha-D-ribose 1''-phosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43601", "l": "3-oxoeicosanoyl-[ACP] + H(+) + NADPH => 3R-hydroxyeicosanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12369", "l": "2-dehydro-D-gluconate + A => 2,5-didehydro-D-gluconate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161293", "l": "Tropoelastin forms aggregate globules (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68217", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1,2-dihexanoylglycerol => 1,2-dihexanoyl-3-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909732", "l": "Phosphorylation of STAT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64626", "l": "(2E)-geranyl acetate + CoA => (2E)-geraniol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15369", "l": "2,3-dihydroxybenzoate + O2 = 2-carboxy-cis,cis-muconate + 2 H(+)", "d": []}, {"i": "EC:1.13.11.28", "l": "\"2,3-dihydroxybenzoate 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57541", "l": "a 5'-end NTP-ribonucleotide-RNA + H2O => a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.108", "l": "\"HtrA2 peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19075", "l": "ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein] => ATP + L-seryl-[I-kappa-B protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26152", "l": "(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate", "d": []}, {"i": "EC:2.5.1.78", "l": "\"6,7-dimethyl-8-ribityllumazine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71637", "l": "phosphate(out) + 2 thiosulfate(in) => phosphate(in) + 2 thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814153", "l": "ADO oxidises 2AET to HTAU (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15172", "l": "H2O + N-succinyl-L-glutamate <=> L-glutamate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.165", "l": "\"chlorophyllide a 3(1)-hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39253", "l": "(11Z)-eicosenoyl-CoA + NADP(+) => (2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814734", "l": "CDSN binds the cornified envelope (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928597", "l": "EPH:EFN dimers tetramerise (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111238", "l": "Formation of ADAR2  homodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031518", "l": "NR1H2,3 binds the APOC1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879562", "l": "SLCO2B1 has a narrow substrate specificity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701147", "l": "TRPV1 binds TRPV1 blockers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22738", "l": "5,10-methenyltetrahydrofolate + NH4(+) => 5-formimidoyltetrahydrofolate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047328", "l": "acyl-phosphate-hexose phosphotransferase activity", "d": ["Catalysis of the reaction: D-hexose + acyl phosphate = D-hexose phosphate + an acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53898", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696267", "l": "RND3 binds GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68939", "l": "ATP + H(+) + NADPH + nonanoate <=> AMP + diphosphate + NADP(+) + nonanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-606289", "l": "New CENPA-containing nucleosomes are deposited at the centromere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52508", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5227009", "l": "ABCF1 binds EIF2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.16.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56427", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45792", "l": "2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 = [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443779", "l": "Linkage of L1 with treadmilling F-actin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34332", "l": "H(+) + indole-3-pyruvate + NADPH + O2 => (indol-3-yl)acetate + CO2 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71319", "l": "chloride(out) + L-cysteine(out) + 2 Na(+)(out) = chloride(in) + L-cysteine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28295", "l": "(2E,6E)-farnesyl diphosphate => (-)-(E)-beta-caryophyllene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9733969", "l": "Bile salts dissociate from FABP6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64147", "l": "H2O + N-(9Z-octadecenoyl)-L-methionine <=> (9Z)-octadecenoate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:1902444", "l": "riboflavin binding", "d": ["Binding to riboflavin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264622", "l": "Cho is acetylated to AcCho by CHAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102581", "l": "cyanidin 3-O-glucoside-p-coumaroyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 4-coumaryl-CoA + H+ <=> cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0036408", "l": "histone H3K14 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14)."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0070704", "l": "sterol desaturase activity", "d": ["Catalysis of the introduction of a double bond into a sterol molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610722", "l": "CK1 phosphorylates p-GLI3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507869", "l": "Aquaporins passively transport glycerol into cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18777", "l": "an alkylmercury + H(+) = an alkane + Hg(2+)", "d": []}, {"i": "EC:4.99.1.2", "l": "\"alkylmercury lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682992", "l": "KDM4A,B bind H4K20Me2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41109", "l": "2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019768", "l": "high-affinity IgE receptor activity", "d": ["Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130706", "l": "MHC class II antigen processing (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696356", "l": "OSCAR binds collagen and SP-D (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52748", "l": "alpha-isomaltosyl-(1->3)-isomaltose + H2O = 2 isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218815", "l": "p-6Y-VEGFR2 binds NCK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50829", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 => (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49180", "l": "a bacteriochlorophyllide d + S-adenosyl-L-methionine = a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.333", "l": "\"bacteriochlorophyllide d C-20 methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63628", "l": "ATP + hexadecanoate + holo-[ACP] = AMP + diphosphate + hexadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190790", "l": "Assembly of gap junction plaques (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.576939455547432", "identifiers": [{"i": "GO:0008134", "l": "transcription factor binding", "d": ["Binding to a transcription factor, a protein required to initiate or regulate transcription."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13491", "l": "berberine + 2 H2O2 => (S)-canadine + H(+) + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18077", "l": "L-arginyl-[dinitrogen reductase] + NAD(+) = H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide", "d": []}, {"i": "EC:2.4.2.37", "l": "\"NAD(+)--dinitrogen-reductase ADP-D-ribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61097", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] => (S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047425", "l": "1-pyrroline-4-hydroxy-2-carboxylate deaminase activity", "d": ["Catalysis of the reaction: 4-hydroxy-1-pyrroline-2-carboxylate + H2O + H+ = 2,5-dioxopentanoate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047890", "l": "flavanone 4-reductase activity", "d": ["Catalysis of the reaction: (2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033784", "l": "senecionine N-oxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + senecionine = H2O + NADP+ + senecionine N-oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170159", "l": "Translocation of Cdc25 to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936851", "l": "AHRR binds ARNT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33630", "l": "ATP + CoA + decanoate <=> AMP + decanoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53465", "l": "1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11830", "l": "a 3'-end 2'-phospho-ribonucleotide-RNA + H(+) => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4411402", "l": "Activation of NLK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47392", "l": "H2O + hexadecanoate ester = an aliphatic alcohol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693540", "l": "MRN activates ATM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014296", "l": "RAC2 GEFs activate RAC2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804879", "l": "MDM2 ubiquitinates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10219", "l": "[DNA-directed RNA polymerase] + ATP <=> ADP + H(+) + phospho-[DNA-directed RNA polymerase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781897", "l": "USP11 deubiquitinates NFKBIA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854981", "l": "SHC1 in the RET complex is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73314", "l": "L-thyroxine sulfate(out) <=> L-thyroxine sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434084", "l": "p-IRAK2- TRAF6 dissociates from the activated chTLR complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54545", "l": "1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine => 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67532", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.104", "l": "\"steryl-beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47084", "l": "4-methylsulfanyl-2-oxobutanoate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507873", "l": "Aquaporins passively transport urea out of cells (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58687", "l": "FAD + 2 H(+) + NADPH + O2 <=> FADH2-C4alpha-hydroperoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211960", "l": "CYP2U1 19-hydroxylates ARA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210294", "l": "Interaction of PECAM-1 and SHP-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56983", "l": "4-hydroxybenzyl alcohol + 2 oxidized [azurin] <=> 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45704", "l": "(E)-sinapyl alcohol + NADP(+) = (E)-sinapaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5334794", "l": "FABPs bind LCFAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419645", "l": "Dimerization of LIMK1 by Hsp90 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74571", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] = N(alpha)-acetyl-L-methionine + N-terminal L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64740", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine = 3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000340", "l": "RNA 7-methylguanosine cap binding", "d": ["Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56545", "l": "H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74434", "l": "1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43629", "l": "L-serine + NAD(+) => aminoacetaldehyde + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17360", "l": "O2 + 2 R'C(R)SH <=> H2O2 + R'C(R)S-S(R)CR'", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36910", "l": "(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA <=> (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706837", "l": "AR binds AR antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0015185", "l": "gamma-aminobutyric acid transmembrane transporter activity", "d": ["Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8979071", "l": "KDM6B binds iron (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64874", "l": "dihydroxyacetone phosphate + glycolaldehyde => D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23975", "l": "(2E)-glutaconyl-CoA + H(+) + Na(+)(in) <=> (2E)-butenoyl-CoA + CO2 + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39999", "l": "a sphingoid 1-phosphate = a fatty aldehyde + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.171", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38831", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34824", "l": "(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O => CO2 + 2 CoA + curcumin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57093", "l": "AH2 + S-(methylsulfanyl)glutathione => A + glutathione + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34243", "l": "GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide", "d": []}, {"i": "EC:2.7.7.77", "l": "\"molybdenum cofactor guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1008270", "l": "Activated TAK1 leaves endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878117", "l": "RUNX3 binds ZFHX3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190168", "l": "HMBL spontaneously transforms to URO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37927", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047688", "l": "aspartate 4-decarboxylase activity", "d": ["Catalysis of the reaction: L-aspartate = L-alanine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755328", "l": "SARS-CoV-2 8 binds class I MHC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089720", "l": "caspase binding", "d": ["Binding to a caspase family protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14785", "l": "RNA(n) + UTP = diphosphate + RNA(n)-3'-uridine ribonucleotide", "d": []}, {"i": "EC:2.7.7.52", "l": "\"RNA uridylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43243", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39672", "l": "(9Z)-hexadecenoyl-CoA + AH2 + O2 => (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69992", "l": "3-dehydro-6-deoxoteasterone + NADP(+) => (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202248", "l": "Phosphorylation of PLC-gamma1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39046", "l": "22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19308", "l": "3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001051", "l": "plastid single-subunit type RNA polymerase binding", "d": ["Binding to a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33373", "l": "alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein] => alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10124", "l": "H(+) + NADPH + O2 + phenylacetone = benzyl acetate + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.92", "l": "\"phenylacetone monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48349", "l": "a uridine in RNA => a pseudouridine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30380", "l": "(2E,6E)-farnesyl diphosphate => (+)-beta-chamigrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018741", "l": "linear primary-alkylsulfatase activity", "d": ["Catalysis of the reaction: a primary linear alkyl sulfate ester + H2O =>a primary alcohol + H(+) + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46872", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA = a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44130", "l": "CoA + hexadecanyl (9E)-octadecenoate => (9E)-octadecenoyl-CoA + hexadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41157", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-(8E)-octadecenoate + H(+) => 1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158399", "l": "kallikrein binds SERPING1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236970", "l": "Proteasomal clevage of exogenous antigen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419490", "l": "Binding of ATP to P2X receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429698", "l": "PRKD1,2,3 phosphorylates CERT1-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483186", "l": "PC is converted to PS by PTDSS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043530", "l": "adenosine 5'-monophosphoramidase activity", "d": ["Catalysis of the reaction: adenosine 5'-monophosphoramidate + H2O = AMP + NH4+. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester."]}, {"i": "RHEA:67916", "l": "adenosine 5'-phosphoramidate + H2O = AMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64629", "l": "acetyl-CoA + octan-1-ol => CoA + octyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32519", "l": "(2E)-geranyl diphosphate + S-adenosyl-L-methionine = (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.255", "l": "\"geranyl diphosphate 2-C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51932", "l": "2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite = 2 Fe(II)-[cytochrome c3] + thiosulfate", "d": []}, {"i": "EC:1.8.2.5", "l": "\"thiosulfate reductase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66851", "l": "2 Cu(2+) + NADH <=> 2 Cu(+) + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451895", "l": "IL2RG binds JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46276", "l": "(S)-malate + H(+) = (S)-lactate + CO2", "d": []}, {"i": "EC:4.1.1.101", "l": "\"malolactic enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102406", "l": "omega-hydroxypalmitate O-sinapoyl transferase activity", "d": ["Catalysis of the reaction: sinapoyl-CoA + 16-hydroxypalmitate <=> coenzyme A + 16-sinapoyloxypalmitate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36192", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848414", "l": "Activated PTK6 binds CDKN1B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64014", "l": "A + 3 CO2 + 4 CoA + fumigermin + H2O + 3 S-adenosyl-L-homocysteine => acetyl-CoA + AH2 + 3 malonyl-CoA + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43242", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445084", "l": "Phosphorylation of L1 by SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70973", "l": "3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+) => D-dopa + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.25", "l": "\"4-alpha-glucanotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61673", "l": "ATP + H(+) + L-cysteine => diphosphate + L-cysteinyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53471", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21812", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.23", "l": "\"cholesterol 7alpha-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22761", "l": "Cypridina luciferin + O2 => CO2 + hnu + oxidized Cypridina luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785181", "l": "LMF1,2 bind LIPC dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047201", "l": "beta-glucogallin O-galloyltransferase activity", "d": ["Catalysis of the reaction: 2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28025", "l": "ATP + holo-[ACP] + octanoate <=> AMP + diphosphate + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.46", "l": "\"galactan 5-O-arabinofuranosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047414", "l": "2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase activity", "d": ["Catalysis of the reaction: (2Z)-2-(acetamidomethylene)-3-(hydroxymethyl)succinate + 2 H2O + H+ = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31061", "l": "2 H(+) + imidazole-4-acetate + NADH => H2O + imidazole-4-acetaldehyde + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220981", "l": "NOTCH1 PEST domain mutants stimulate HEY transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71278", "l": "2 Na(+)(out) + taurolithocholate 3-sulfate(out) <=> 2 Na(+)(in) + taurolithocholate 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62887", "l": "O2 + 4 semiviriditoxin <=> 2 (M)-viriditoxin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29702", "l": "dimethyl sulfoxide(in) <=> dimethyl sulfoxide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434030", "l": "TBK1 is recruited to the Viral dsRNA:TLR3:TICAM1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55731", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9679044", "l": "FKBP1A binds sirolimus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67431", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65266", "l": "AH2 + chrodrimanin C => 3-hydroxypentacecilide A + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46415", "l": "a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655825", "l": "SREBP1A,1C,2:SCAP binds CopII Coat Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40646", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49489", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate => 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23243", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42334", "l": "ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate => ATP + L-glutamate + oxidized coenzyme F420-2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19736", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) <=> bacteriochlorophyllide a + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050083", "l": "malyl-CoA lyase activity", "d": ["Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654163", "l": "Activated FGFR4 binds PLCG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37463", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48743", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine <=> [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59310", "l": "D-galactonate + H(+) => D-galactono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624133", "l": "ARL3:GTP binds the UNC119B complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56133", "l": "(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA => a thymidine dimer in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73009", "l": "D-glyceraldehyde 3-phosphate + glycolaldehyde => D-arabinose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016519", "l": "gastric inhibitory peptide receptor activity", "d": ["Combining with gastric inhibitory peptide (GIP) and transmitting the signal across the membrane to activate an associated G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.150", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2299620", "l": "Collagen XI cross-links with collagen II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50259", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008427", "l": "calcium-dependent protein kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a calcium-dependent protein kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174741", "l": "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54924", "l": "(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19935", "l": "D-glucose + phosphate => alpha-D-glucose 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28069", "l": "CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) <=> alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57065", "l": "D-apionolactone + H2O => D-apionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296043", "l": "Activation of HCN channels (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875568", "l": "RAPGEF1 activates RAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672978", "l": "RAF phosphorylates MAP2K dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74754", "l": "dodecapentaneoyl-[polyketide synthase] + fumagillol <=> holo-[polyketide synthase] + prefumagillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944257", "l": "Association of procollagen type XXIV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75400", "l": "2 H(+)(out) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(out) => 2 H(+)(in) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444661", "l": "HCAR2 binds HCAR2 ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617087", "l": "CEBPA binds the promoter of the GFI1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047460", "l": "L-2-amino-4-chloropent-4-enoate dehydrochlorinase activity", "d": ["Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate + H2O = 2-oxopent-4-enoate + chloride + H+ + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57758", "l": "C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247837", "l": "WNT ligands traffic to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.48", "l": "\"carnitine--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71849", "l": "LDH tetramer reduces PYR to LACT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809680", "l": "MTMR12 binds MTM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17979", "l": "a long-chain fatty acid + 3 H(+) + 2 NADH => a long-chain primary fatty alcohol + H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22022", "l": "ADP + H(+) + molybdate(in) + phosphate => ATP + H2O + molybdate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140791", "l": "histone H2AXS140 phosphatase activity", "d": ["Catalysis of the reaction: histone H2AX serine phosphate (position 140) + H2O = histone H2AX serine (position 140) + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70054", "l": "2-oxoadipate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373746", "l": "SEMA4D interacts with CD45 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21679", "l": "2 dimethylallyl diphosphate <=> (R)-lavandulyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59518", "l": "H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate => acetylsalicylate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692809", "l": "CDC42 binds effectors at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22878", "l": "(R)-mandelate + NH4(+) => (R)-mandelamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24342", "l": "(R)-acetoin + H(+) + NADH => (R,R)-butane-2,3-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20553", "l": "(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA", "d": []}, {"i": "EC:5.1.99.1", "l": "\"methylmalonyl-CoA epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67185", "l": "(glycyl)(n)-glycyl-L-glutamyl-[protein] + ATP + glycine => (glycyl)(n+1)-glycyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22892", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH", "d": []}, {"i": "EC:1.5.1.15", "l": "\"methylenetetrahydrofolate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37057", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate => 3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45445", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246478", "l": "APOM binds retinoids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950344", "l": "Expression of BolA-like protein 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42932", "l": "cytidine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18699", "l": "(4-hydroxyphenyl)acetaldehyde + CO2 => 3-(4-hydroxyphenyl)pyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389354", "l": "Activation of Vav1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67366", "l": "L-serine + L-threonine => H2O + L-threonyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784765", "l": "p-Y705-STAT3 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46343", "l": "ATP + N-hexadecanoylsphing-4-enine <=> ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769383", "l": "CBY1 binds beta-catenin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17007", "l": "1-phospho-alpha-D-glucuronate + ADP + H(+) => ATP + D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15038", "l": "putrescine + S-adenosyl-L-methionine => H(+) + N-methylputrescine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30698", "l": "3-aminopropanal + H2O + NAD(+) <=> beta-alanine + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67536", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70674", "l": "N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA <=> CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390674", "l": "ADRB1 bind ADR,NAd (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10225", "l": "ATP + pyridoxal => ADP + H(+) + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56888", "l": "UDP-4-dehydro-6-deoxy-alpha-D-glucose = UDP-4-dehydro-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0051800", "l": "phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32824", "l": "phosphate(in) => phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32806", "l": "ATP + H2O + urea(out) <=> ADP + H(+) + phosphate + urea(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450187", "l": "TAK1 is activated within the TAK1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21833", "l": "3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine => 3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32774", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate <=> 2,6-dioxo-6-phenylhexa-3-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430308", "l": "PARVB interacts with Alpha-actinin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57536", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + a ribonucleoside 5'-triphosphate = a 5'-end NTP-ribonucleotide-RNA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28176", "l": "colneleate + H2O => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162187", "l": "DHB is hydroxylated to DHDB by COQ6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043815", "l": "phosphoribosylglycinamide formyltransferase 2 activity", "d": ["Catalysis of the reaction: formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74995", "l": "epierythrostominol(in) = epierythrostominol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74424", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48201", "l": "H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA => reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53684", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39457", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140772", "l": "CoA-dependent peptidyl-lysine N6-palmitoyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl-[protein] + hexadecanoyl-CoA = CoA + H+ + N(6)-hexadecanoyl-L-lysyl-[protein]."]}, {"i": "RHEA:59768", "l": "hexadecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418172", "l": "F2R binds ARRB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50650", "l": "2-(2-methylsulfanyl)ethylmaleate + H2O => 2-(2-methylsulfanyl)ethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71417", "l": "3,3',5-triiodo-L-thyronine(in) + L-phenylalanine(out) => 3,3',5-triiodo-L-thyronine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40775", "l": "2-amino-2-phenylacetonitrile + H(+) + 2 H2O = D-alpha-phenylglycine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730892", "l": "Recruitment of VAV to p-SLP-76 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161293", "l": "Tropoelastin forms aggregate globules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29468", "l": "H(+)(out) + K(+)(in) => H(+)(in) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811479", "l": "ING2 recruits EP300 to TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66521", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53886", "l": "alpha,alpha-trehalose 6-phosphate + CDP + H(+) => CDP-alpha-D-glucose + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61770", "l": "H(+) + rebaudioside D + UDP => rebaudioside A + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0140035", "l": "ubiquitination-like modification-dependent protein binding", "d": ["Binding to a protein upon modification by a ubiquitin-like protein of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51226", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] => 2 Fe(III)-[cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20034", "l": "isopenicillin N => penicillin N", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12844", "l": "pyridoxamine + pyruvate <=> L-alanine + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15763", "l": "H(+) + L-aspartate 4-semialdehyde + NADPH => L-homoserine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32135", "l": "2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700120", "l": "PTN and MDK bind to PTPRZ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022314", "l": "HIPK2 phosphorylates MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41343", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 <=> 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247497", "l": "ERBB3 binds neuregulins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22045", "l": "ATP + H(+)(in) + H2O + K(+)(out) => ADP + 2 H(+)(out) + K(+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40683", "l": "1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol = 1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21956", "l": "UDP-alpha-D-glucose + vitexin = H(+) + UDP + vitexin 2''-O-beta-D-glucoside", "d": []}, {"i": "EC:2.4.1.105", "l": "\"vitexin beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16856", "l": "N(6)-(1,2-dicarboxyethyl)-AMP <=> AMP + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32259", "l": "beta-D-fructose 1-phosphate + methylglyoxal = 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64035", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose <=> a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23247", "l": "propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + norspermidine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173725", "l": "C9 binds C5b:C6:C7:C8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45700", "l": "glycine betaine + H(+) + NADH + O2 = formaldehyde + H2O + N,N-dimethylglycine + NAD(+)", "d": []}, {"i": "EC:1.14.13.251", "l": "\"glycine betaine monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60580", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56269", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73300", "l": "(S)-malate(out) + H(+)(in) + phosphate(in) => (S)-malate(in) + H(+)(out) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852337", "l": "GTSE1 binds TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74471", "l": "(-)-4'-methoxycyclopeptine + 2-oxoglutarate + O2 = (Z)-4'-methoxydehydrocyclopeptine + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964567", "l": "The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds CDK1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672978", "l": "RAF phosphorylates MAP2K dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67100", "l": "fumigatonoid B = fumigatonoid C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16223", "l": "3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214953", "l": "Full-length SNK is cleaved by GD serine protease (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19899", "l": "4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide => H(+) + 2 L-arginine + 3 NADPH + 4 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66359", "l": "(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+) <=> (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112703", "l": "PTPN11 is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186819", "l": "SH2 domain of Src binds to the active receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73671", "l": "ADP(out) + diphosphate(in) = ADP(in) + diphosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27835", "l": "a menaquinone + succinate => a menaquinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944232", "l": "Association of procollagen type XII (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.85", "l": "\"S2P endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.45", "l": "\"N-acetylneuraminate 7-O(or 9-O)-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011543", "l": "DCA binds PDK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296045", "l": "Activation of Potassium transport channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20775", "l": "2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) <=> 5-amino-6-(D-ribitylamino)uracil + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374919", "l": "Noradrenaline clearance from the synaptic cleft (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129375", "l": "Elastin cross-linking by lysyl oxidase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736970", "l": "WWTR1:p-2S-SMAD2,3:SMAD4 binds SMAD7 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9639286", "l": "RRAGC,D exchanges GTP for GDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51996", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21541", "l": "N-(5-phospho-beta-D-ribosyl)anthranilate => 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32930", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23667", "l": "A + a (2R)-2-hydroxycarboxylate <=> a 2-oxocarboxylate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26009", "l": "di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate <=> beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24604", "l": "7-methylxanthine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110235", "l": "OGG1 glycosylase mediated recognition and binding of an 8-oxoguanine opposite to a cytosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693540", "l": "MRN activates ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44353", "l": "ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide C + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50675", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O <=> [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59984", "l": "an N(2)-acyl-L-glutamine + H2O = a carboxylate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13513", "l": "(S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate", "d": []}, {"i": "EC:1.3.1.14", "l": "\"dihydroorotate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102478", "l": "beta-L-arabinofuranosidase activity", "d": ["Catalysis of the reaction: beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O = 2 beta-L-arabinofuranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56596", "l": "(1S,4S)-bornane-2,5-dione + FMNH2 + O2 = (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.155", "l": "\"3,6-diketocamphane 1,2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865276", "l": "PDGF-AB clevage by Furin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71933", "l": "fumarate(in) + 3 Na(+)(in) => fumarate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42160", "l": "(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 = (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.576969997299727", "identifiers": [{"i": "GO:0015250", "l": "water channel activity", "d": ["Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-481044", "l": "Surface deployment of platelet alpha granule membrane components (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52290", "l": "7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74949", "l": "(3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + CO2 + succinate => (3R)-3-[(carboxymethyl)amino]butanoate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2127562", "l": "STRAP binds phosphorylated TGF-beta receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42397", "l": "cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine => 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9689680", "l": "IFNG dimer binds IFNG inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-976801", "l": "Complement factor I complex formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47638", "l": "5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+) => H2O + L-arginine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37241", "l": "H(+) + uridine 2'-phosphate => 2',3'-cyclophospho-UMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953111", "l": "E2F6 binds TFDP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62153", "l": "dGMP + dTTP => dGDP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72067", "l": "(2S)-2-aminobutanoate + ATP + L-glutamate = ADP + gamma-L-glutamyl-(2S)-2-aminobutanoate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13389", "l": "glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.6", "l": "\"glutaryl-CoA dehydrogenase (ETF)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16698", "l": "A + H2O + quinaldate => AH2 + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852337", "l": "GTSE1 binds TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030759", "l": "methylquercetagetin 6-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63603", "l": "H2O + neocasomorphin <=> L-isoleucine + neocasomorphin-(1-5)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111238", "l": "Formation of ADAR2  homodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37830", "l": "(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.49", "l": "\"L-allo-threonine aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804276", "l": "ATM phosphorylates TTC5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38354", "l": "(R)-3-phenyllactate + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5688834", "l": "ATXN3 binds VCP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014141", "l": "HEY2 gene expression is positively regulated by NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31162", "l": "(3S)-hydroxyhexadecanoyl-CoA + NAD(+) <=> 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928624", "l": "EPHBs bind EFNBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59632", "l": "D-xylobiose + O2 = D-xylobiono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029453", "l": "Phosphorylation of VAV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419166", "l": "GEFs activate RhoA,B,C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30246", "l": "4 L-ascorbate + O2 <=> 2 H2O + 4 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25909", "l": "an alditol + O2 => an aldose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004024", "l": "alcohol dehydrogenase activity, zinc-dependent", "d": ["Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc."]}, {"i": "REACT:R-HSA-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004145", "l": "diamine N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018826", "l": "RHOT2 hydrolyzes GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14883", "l": "asparagusate + H(+) + NADH => 3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56914", "l": "(E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH => (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60767", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone <=> cinerin II + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48644", "l": "prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47080", "l": "17beta-hydroxyestr-4-en-3-one + H(+) + NADPH = 17beta-hydroxy-5beta-estran-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50805", "l": "glutathione + prostaglandin J2 => prostaglandin J2-S-(R)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007926", "l": "ATRX binds DAXX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912470", "l": "ATR phosphorylates Histone H2A.X at unsynapsed regions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14196", "l": "3-hydroxybenzoate + AH2 + O2 <=> 2,3-dihydroxybenzoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202604", "l": "Formation of a heteromeric BMP receptor complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47161", "l": "4beta-methylzymosterol-4alpha-carboxylate + NAD(+) => 3-dehydro-4-methylzymosterol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296244", "l": "SUCNR1 binds SUCCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55604", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base = a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54189", "l": "H2O + N-acetyl-L-phenylalanine => acetate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47941", "l": "ganglioside GM2 (d18:1(4E)) + H2O => ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691004", "l": "XPC binds RAD23 and CETN2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16387", "l": "CO2 + H2O + hydroquinone + NADP(+) => 4-hydroxybenzoate + 2 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38683", "l": "ATP + H2O + sphing-4-enine(in) = ADP + H(+) + phosphate + sphing-4-enine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5685319", "l": "CX3 complex formation (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1222376", "l": "NOX2 generates superoxide from oxygen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665388", "l": "ERBB2 ECD mutants heterodimerize with EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56174", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + H2O => FMN + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54160", "l": "2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430135", "l": "p-SLP-76 binds ADAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38711", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68930", "l": "AMP + diphosphate + heptanal + NADP(+) => ATP + H(+) + heptanoate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322429", "l": "XIAP monoubiquinates TLE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15372", "l": "2,3-dihydroxybenzoate + O2 <=> 2-carboxy-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30645", "l": "hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate => phosphate + S-methyl-5'-thioinosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41882", "l": "dodecanoyl-[ACP] + NADP(+) => (2E)-dodecenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40513", "l": "(2S)-3-sulfolactaldehyde + H(+) + NADH => (2S)-3-sulfopropanediol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61200", "l": "acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17209", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O = 2-formylglutarate + NH4(+)", "d": []}, {"i": "EC:3.5.2.18", "l": "\"enamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15902", "l": "(2R)-2-phosphoglycerate => (2R)-3-phosphoglycerate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53167", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41003", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49540", "l": "(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate = (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848930", "l": "PTK6 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944220", "l": "Association of procollagen type XXIII (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32955", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21111", "l": "(S)-3-methyl-2-oxopentanoate + H(+) <=> 2-methylbutanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047515", "l": "1,3-beta-oligoglucan phosphorylase activity", "d": ["Catalysis of the reaction: [oligomeric (1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51328", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = 10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.11", "l": "\"carnosine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68169", "l": "N-(8'-oxogeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65337", "l": "chrodrimanin T + H(+) + NADPH + O2 => chrodrimanin A + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10944", "l": "H2O + psi-UMP = phosphate + pseudouridine", "d": []}, {"i": "EC:3.1.3.96", "l": "\"pseudouridine 5'-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24330", "l": "10-formyldihydrofolate + ADP + phosphate => 7,8-dihydrofolate + ATP + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129362", "l": "Fibrillin microfibril assembly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15563", "l": "8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + sterigmatocystin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8986083", "l": "USP33 deubiquitinates ROBO1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25148", "l": "(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde => H(+) + H2O + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391865", "l": "Recruitment of FAK to NCAM1:Fyn in lipid rafts (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451377", "l": "Interaction of IQGAP1 with nephrin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41110", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27313", "l": "naphthalene-1,2-diol + O2 <=> 2-hydroxychromene-2-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22904", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] = gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.64", "l": "\"peptidase K\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60841", "l": "a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56055", "l": "2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46996", "l": "6-hydroxy-N-methylmyosmine + H2O = 6-hydroxypseudooxynicotine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382053", "l": "Translocation of PDGF from ER to Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032775", "l": "YAP1 binds TEAD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36864", "l": "(9Z)-octadecenoyl-CoA + AH2 + O2 => (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44067", "l": "hexadecanoyl-CoA + octan-1-ol <=> CoA + octyl hexadecanoyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43337", "l": "H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) => CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15950", "l": "(R)-2-hydroxyoctadecanoate + NAD(+) => 2-oxooctadecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912368", "l": "SPO11 hydrolyzes DNA forming double-strand breaks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.46", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64785", "l": "S-ethyl-L-cysteine => 2-aminoprop-2-enoate + ethanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052895", "l": "N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity", "d": ["Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N1-acetylspermidine + 3-aminopropanal + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351208", "l": "Spermidine  => N-acetylated spermidine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-984606", "l": "Kinesin-5 is a homotetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28886", "l": "H(+)(in) + L-threonine(in) <=> H(+)(out) + L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43330", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40769", "l": "(20S)-ginsenoside Rg1 + D-xylose => (20S)-ginsenoside R1 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27405", "l": "a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2", "d": []}, {"i": "EC:1.2.5.1", "l": "\"pyruvate dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030585", "l": "phosphoenolpyruvate carboxykinase (diphosphate) activity", "d": ["Catalysis of the reaction: diphosphate + oxaloacetate = CO2 + phosphate + phosphoenolpyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66864", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + quiannulatene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029471", "l": "Hydrolysis of PC to PA by PLD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602672", "l": "Defective IRAK4 does not bind MyD88 within the TLR2/4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56477", "l": "(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21070", "l": "AH2 + nitrate => A + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31914", "l": "beta-D-fructose 1,6-bisphosphate + methylglyoxal <=> 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12122", "l": "ADP-alpha-D-glucose + diphosphate => alpha-D-glucose 1-phosphate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29453", "l": "H2 + phosphate => H2O + phosphonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865994", "l": "GAB1 binds PTPN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10882", "l": "7-methylxanthine + D-ribose + H(+) => 7-methylxanthosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64602", "l": "a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57389", "l": "(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55793", "l": "butan-2-one + H(+) + NADH + O2 => 1-hydroxy-2-butanone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61693", "l": "holo-[peptidyl-carrier protein] + L-threonyl-5'-AMP => AMP + L-threonyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69182", "l": "AMP + thiamine triphosphate => ADP + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70650", "l": "D-serine(out) + H(+)(out) <=> D-serine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004051", "l": "arachidonate 5-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32378", "l": "limonene-1,2-diol + NAD(+) <=> 1-hydroxylimonen-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12059", "l": "D-erythrose 4-phosphate + H2O + NAD(+) <=> 4-phospho-D-erythronate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55884", "l": "[aequorin] + 3 Ca(2+) = [aequorin]--dioxetanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41513", "l": "L-ornithine + NADH + O2 => H2O + N(5)-hydroxy-L-ornithine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169398", "l": "ISGylation of host protein filamin B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167419", "l": "The receptor:G-protein complex releases GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852317", "l": "PLK1 phosphorylates GTSE1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32757", "l": "apigenin + CO2 + H(+) + H2O + succinate => (2S)-naringenin + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73830", "l": "an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374662", "l": "Translocation of Ezrin to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50383", "l": "3 H(+) + 3 malonyl-CoA <=> 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59860", "l": "3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73612", "l": "CTP(out) + dCDP(in) => CTP(in) + dCDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58840", "l": "cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15344", "l": "ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide <=> ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701064", "l": "TRPV1 binds TRPV1 agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27617", "l": "(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate <=> di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25584", "l": "alpha-L-rhamnose = beta-L-rhamnose", "d": []}, {"i": "EC:5.1.3.32", "l": "\"L-rhamnose mutarotase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653886", "l": "B4GALT1 binds LALBA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29166", "l": "2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out) <=> 2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30019", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + H(+) + lipid A-core", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18623", "l": "a (2R,3R)-dihydroflavonol + CO2 + succinate => 2-oxoglutarate + a (2S)-flavan-4-one + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46943", "l": "AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] <=> ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60647", "l": "3'-phosphoadenylyl sulfate + androsterone <=> adenosine 3',5'-bisphosphate + androsterone 3alpha-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11415", "l": "6-hydroxymethyl-7,8-dihydropterin + ATP <=> (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944233", "l": "Association of procollagen type XIX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66811", "l": "5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH <=> 7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71229", "l": "2 Na(+)(in) + selenocyanate(in) => 2 Na(+)(out) + selenocyanate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102246", "l": "6-amino-6-deoxyfutalosine hydrolase activity", "d": ["Catalysis of the reaction: aminodeoxyfutalosinate + H2O <=> dehypoxanthine futalosine + adenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16545", "l": "formyl-CoA + oxalate = formate + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.24", "l": "\"aromatic desulfoglucosinolate sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29230", "l": "H(+)(in) + indole(in) <=> H(+)(out) + indole(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34891", "l": "selenite(in) = selenite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371582", "l": "HSBP1 binds HSF1 trimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018737", "l": "2-ketocyclohexane-1-carboxyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: 2-ketocyclohexane-1-carboxyl-CoA + H2O = pimeloyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675431", "l": "PP2A dephosphorylates RAF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706293", "l": "Active FLT3 binds to CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21650", "l": "3-phenylpyruvate + CO2 + H2O => H(+) + prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74259", "l": "H2O + L-homoseryl-tRNA(Lys) = H(+) + L-homoserine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030269", "l": "tetrahydromethanopterin S-methyltransferase activity", "d": ["Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M. 2-(methylthio)ethanesulfonate is also known as methyl-CoM."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65469", "l": "1-propanol + acetyl-CoA => CoA + propyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13030", "l": "H2O + N-acetyl-D-glucosamine + O2 => H(+) + H2O2 + N-acetyl-D-glucosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39592", "l": "(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA => (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22561", "l": "(3R)-vestitone + NADP(+) => 2'-hydroxyformononetin + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647746", "l": "EML4 trimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225950", "l": "Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49577", "l": "AH2 + GTP + S-adenosyl-L-methionine => (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48535", "l": "ganglioside GQ1c (d18:1(4E)) + H2O <=> ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614271", "l": "Autocleavage of ADGRG6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43315", "l": "ATP + N-(hexanoyl)sphing-4-enine <=> ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199425", "l": "PHLPP dephosphorylates S473 in AKT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444100", "l": "PROT mediates L-proline uptake (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928631", "l": "GIT1 binds bPIX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49607", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) <=> 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1470010", "l": "Dimerization of STATs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793400", "l": "NOTCH1 coactivator complex binds the TBX6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420206", "l": "Phosphorylation of SRC-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19894", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP => 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34866", "l": "(Z)-2,3-didehydroadipyl-CoA + H2O <=> 3-hydroxyadipyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913374", "l": "Phosphorylated SHC1 recruits SHIP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050596", "l": "vinorine hydroxylase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + vinorine = H2O + NADP+ + vomilenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59590", "l": "ADP + beta-alanyl-L-ornithine + H(+) + phosphate => ATP + beta-alanine + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663273", "l": "RORA, EP300, PPARGC1A bind NR1D1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74718", "l": "Internalisation of the insulin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9817575", "l": "ERO1B oxidizes P4HB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29022", "l": "D-galactose(in) + H(+)(in) <=> D-galactose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59723", "l": "D-maltohexaono-1,5-lactone + H2O <=> D-maltohexaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37602", "l": "(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 <=> (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31276", "l": "(S)-3-hydroxy-2-methylpropanoate + NAD(+) => (S)-methylmalonate semialdehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005122", "l": "torso binding", "d": ["Binding to a torso (tor) protein, a receptor tyrosine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001000", "l": "bacterial-type RNA polymerase core enzyme binding", "d": ["Binding to a bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54485", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine => 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352268", "l": "Cleavage of Satb1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047736", "l": "cellobiose epimerase activity", "d": ["Catalysis of the reaction: cellobiose = D-glucosyl-D-mannose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070281", "l": "pyridoxamine binding", "d": ["Binding to pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27389", "l": "(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O = pyruvate + salicylaldehyde", "d": []}, {"i": "EC:4.1.2.45", "l": "\"trans-o-hydroxybenzylidenepyruvate hydratase-aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609747", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN3A (GRIN3A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429730", "l": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53745", "l": "glycyl-tRNA(Ala) + H2O => glycine + H(+) + tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26317", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate", "d": []}, {"i": "EC:4.1.99.20", "l": "\"3-amino-4-hydroxybenzoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49791", "l": "chenodeoxycholoyl-CoA + glycine <=> CoA + glycochenodeoxycholate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10666", "l": "H(+) + NADH + perillyl aldehyde => NAD(+) + perillyl alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25160", "l": "2-oxoglutarate + L-ornithine = L-glutamate + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70382", "l": "3-oxosphinganine + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664850", "l": "ATM binds PEX5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77607", "l": "Formation of stem-loop structure in ApoB mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15321", "l": "(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.93", "l": "\"3,9-dihydroxypterocarpan 6a-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0140223", "l": "general transcription initiation factor activity", "d": ["A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102196", "l": "cortisol dehydrogenase activity", "d": ["Catalysis of the reaction: cortisol + NADP <=> cortisone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56307", "l": "ATP + H2O + rifampicin <=> 21-phosphorifampicin + AMP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32737", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371422", "l": "ATP hydrolysis by HSP70 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23878", "l": "H2O + xanthoaphin => protoaphin aglucone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214878", "l": "PLL kinase binds to TL:WEK:MYD88:TUB 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71556", "l": "5-C(alpha)-glycyl-dTMP in DNA + H(+) => 5-aminoethyl-dUMP in DNA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102259", "l": "1,2-diacylglycerol acylhydrolase activity", "d": ["Catalysis of the reaction: H2O + a 1,2-diacyl-sn-glycerol = a monoglyceride + a fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938231", "l": "RUNX1:CBFB binds CREBBP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418456", "l": "cGMP is degraded by PDEs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416358", "l": "G alpha (q) inhibits PI3K alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351876", "l": "Caspase-mediated cleavage of occludin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44801", "l": "1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+) => 2-demethylmenaquinol-6 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862733", "l": "CCR2, CCR3 bind CCL13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75744", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH => 10-hydroxy-(11E)-octadecenoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375140", "l": "CDO binds promyogenic cadherins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73935", "l": "griseophenone B + H(+) + O2 + reduced [NADPH--hemoprotein reductase] = desmethyl-dehydrogriseofulvin + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3858489", "l": "ppDVL binds DAAM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416698", "l": "SEMA5A binds to PLXNB3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22607", "l": "D-mannose <=> D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909724", "l": "Recruitment of IFNAR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17775", "l": "AMP + diphosphate + L-cysteinyl-tRNA(Cys) => ATP + L-cysteine + tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3095889", "l": "MMACHC dealkylates RCbl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.916538309327947", "identifiers": [{"i": "GO:0016712", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004466", "l": "long-chain-acyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: a long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419166", "l": "GEFs activate RhoA,B,C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446364", "l": "Migfilin interacts with VASP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53725", "l": "ATP + N-acetyl-D-glucosamine => ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033900", "l": "ribonuclease F activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA precursor into two, leaving 5'-hydroxy and 3'-phosphate groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15940", "l": "a primary alcohol + NADP(+) <=> an aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605768", "l": "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399952", "l": "Phosphorylation of LIMK-1 by PAK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22722", "l": "ADP + H(+) + N(pros)-phospho-L-histidyl-[protein] => ATP + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30885", "l": "D-glucarate + 3 H(+) + NADH => D-glucurono-3,6-lactone + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49433", "l": "cholate + lithocholoyl-CoA => choloyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240782", "l": "E2F1/2/3 stimulates EED transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56721", "l": "2 Fe(III)-[cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate => 2 Fe(II)-[cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0061660", "l": "Atg12 ligase activity", "d": ["Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S = X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55088", "l": "eburicol + S-adenosyl-L-methionine = (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63750", "l": "UDP + zolarsartan-2-N-beta-D-glucuronide => UDP-alpha-D-glucuronate + zolasartan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755304", "l": "MUL1 ubiquitinates UBXN7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389919", "l": "Grb2 binds pBTLA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69100", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080004", "l": "thalian-diol desaturase activity", "d": ["Catalysis of the reaction: a thalian-diol = a desaturated thalian-diol. This reaction is the introduction of a double bond to a thalian-diol molecule at carbon 15."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40325", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015416", "l": "ABC-type phosphonate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18555", "l": "dihydroxyfumarate + H(+) + NADH => (2R,3S)-tartrate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000404", "l": "heteroduplex DNA loop binding", "d": ["Binding to a DNA segment containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917696", "l": "Cargo Sequestration (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52891", "l": "N-phenylhydroxylamine + NADP(+) <=> H(+) + NADPH + nitrosobenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798373", "l": "MDM2 ubiquitinates DYRK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769394", "l": "AKT phosphorylates CBY1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690896", "l": "SOX9 and GATA4 bind the DMRT1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769419", "l": "NPAS4 binds RET gene enhancer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50496", "l": "acetyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10441", "l": "D-glucono-1,5-lactone + H2O => D-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35074", "l": "4-methylphenol(in) <=> 4-methylphenol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23067", "l": "an alkanesulfonate + FMNH2 + O2 <=> an aldehyde + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61222", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005119", "l": "smoothened binding", "d": ["Binding to a smoothened (smo) protein, which interacts with patched to transmit hedgehog signals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64700", "l": "1-phenylethanol + NAD(+) = acetophenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693761", "l": "FA2H hydroxylates CERA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14123", "l": "3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59120", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+) = 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2", "d": []}, {"i": "EC:4.1.1.117", "l": "\"2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797810", "l": "PTPRD binds IL1RAPL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73075", "l": "luteolin + S-adenosyl-L-methionine = H(+) + luteolin 7-methyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69643", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74509", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B + H2O => [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017178", "l": "diphthine-ammonia ligase activity", "d": ["Catalysis of the reaction: ATP + diphthine + NH4 = ADP + diphthamide + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62613", "l": "adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15459", "l": "catechol + H(+) + NADH => cis-1,2-dihydrobenzene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015620", "l": "ferric-enterobactin transmembrane transporter activity", "d": ["Enables the transfer of ferric-enterobactin from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49245", "l": "NAD(+) + resolvin E1 => 18-oxo-resolvin E1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63752", "l": "kermesate + UDP-alpha-D-glucose = carminate + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27885", "l": "2',3'-cyclophospho-CMP + H2O <=> 3'-CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140942", "l": "histone H3K9 dimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl9-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl9-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27367", "l": "bromomethane + S-adenosyl-L-homocysteine => bromide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36983", "l": "(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62647", "l": "(5Z,8Z)-eicosadienoate + O2 <=> (5S)-hydroperoxy-(6E,8Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11967", "l": "5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O <=> 5alpha-cholestane-3beta,5,6beta-triol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948066", "l": "K63polyUb-IRAK1 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005094", "l": "Rho GDP-dissociation inhibitor activity", "d": ["Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19238", "l": "4-carboxymethyl-4-methylbut-2-en-1,4-olide => 4-carboxymethyl-3-methylbut-2-en-1,4-olide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25730", "l": "N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45114", "l": "13-hydroxy-gamma-tocopherol + H2O + NADP(+) => gamma-tocopherol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11903", "l": "(2R,3S)-homoisocitrate + NAD(+) <=> 2-oxoadipate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45967", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O <=> 2 AMP + ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857308", "l": "Activated CEBPB and NFKB complex bind IL8 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37338", "l": "5,6-dihydrothymine + H2O <=> 3-(carbamoylamino)-2-methylpropanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205118", "l": "TRAF6 polyubiquitinates NRIF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58514", "l": "1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983259", "l": "Kinesins move along microtubules consuming ATP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033909", "l": "fucoidanase activity", "d": ["Catalysis of the endohydrolysis of 1,2-alpha-L-fucoside linkages in fucoidan without release of sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72726", "l": "UDP-alpha-D-xylose(in) + UMP(out) <=> UDP-alpha-D-xylose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17076", "l": "acetyl-CoA + cortisol <=> CoA + cortisol 21-acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964274", "l": "G alpha (12) binds BTK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17664", "l": "ATP + CoA + succinate <=> ADP + phosphate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043816", "l": "phosphoserine-tRNA(Cys) ligase activity", "d": ["Catalysis of the reaction: tRNA(Cys) + O-phospho-L-serine + ATP = AMP + diphosphate + phosphoseryl-tRNA(Cys)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983148", "l": "Interaction of Erp57 with MHC class I HC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56749", "l": "an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73932", "l": "Resynthesis of excised residue by POLB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.98", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31696", "l": "(9Z,12Z)-octadecadienoate + O2 => (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4549382", "l": "Defective ALG1 does not transfer the first Man to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13182", "l": "ATP + H2O + nitrate(out) => ADP + H(+) + nitrate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640195", "l": "RRAGA,B hydrolyzes GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36065", "l": "diphosphate + kunzeaol => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57786", "l": "4-nitrocatechol + H(+) + NAD(+) + nitrite => 1,4-dinitrobenzene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66461", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O => 14betaH-scalarane-17alpha-19-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63304", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27694", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23856", "l": "H(+) + Hg + NADP(+) = Hg(2+) + NADPH", "d": []}, {"i": "EC:1.16.1.1", "l": "\"mercury(II) reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34510", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate <=> N,N-diacetyllegionaminate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49233", "l": "D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] => D-mannose 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851866", "l": "MET binds RANBP10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21480", "l": "2-furoyl-CoA + A + H2O = 5-hydroxy-2-furoyl-CoA + AH2 + H(+)", "d": []}, {"i": "EC:1.3.99.8", "l": "\"2-furoyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645481", "l": "TIFA oligomerization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052754", "l": "GTP:coenzyme F420 guanyltransferase activity", "d": ["Catalysis of the reaction: GTP + factor gamma-F420-2 + H+ = coenzyme F390-G + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60264", "l": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.364", "l": "\"[histone H3]-lysine(4) N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28298", "l": "(2E,6E)-farnesyl diphosphate = (E)-gamma-bisabolene + diphosphate", "d": []}, {"i": "EC:4.2.3.59", "l": "\"(E)-gamma-bisabolene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45227", "l": "(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA <=> (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43815", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050384", "l": "urate-ribonucleotide phosphorylase activity", "d": ["Catalysis of the reaction: 3-(beta-D-ribofuranosyl)uric acid + phosphate = alpha-D-ribose 1-phosphate + H+ + urate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0046933", "l": "proton-transporting ATP synthase activity, rotational mechanism", "d": ["Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807581", "l": "HTN5, (HTN1, HTN3) binds fungal SSA1/SSA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40492", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35933", "l": "3''-deamino-3''-hydroxykanamycin X + H(+) + UDP => 2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-419166", "l": "GEFs activate RhoA,B,C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39393", "l": "(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+) => (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48666", "l": "12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0015166", "l": "polyol transmembrane transporter activity", "d": ["Enables the transfer of a polyol from one side of a membrane to the other. A polyol is any polyhydric alcohol."]}, {"i": "REACT:R-HSA-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41611", "l": "3'-phosphoadenylyl sulfate + alpha,alpha-trehalose <=> 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617064", "l": "SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24149", "l": "D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13928", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine <=> holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15962", "l": "4-hydroxymandelonitrile + UDP-alpha-D-glucose => H(+) + taxiphyllin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53430", "l": "a thymidine in DNA + S-methyl-L-cysteinyl-[protein] => a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38376", "l": "bacterioruberin => bisanhydrobacterioruberin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66436", "l": "NADP(+) + pentan-3-one = H(+) + NADPH + pent-1-en-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0004585", "l": "ornithine carbamoyltransferase activity", "d": ["Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801762", "l": "REG3A oligomerize to form a pore complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64812", "l": "acetyl-CoA + S-(2-aminoethyl)-homocysteine = CoA + H(+) + S-(2-acetamidoethyl)-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109857", "l": "MAP2K1 binds MAPK3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68993", "l": "3-amino-4-hydroxybenzoate + H(+) + NADPH + O2 => 3-amino-2,4-dihydroxybenzoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41660", "l": "dihydrosanguinarine + NAD(+) = NADH + sanguinarine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0051731", "l": "polynucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793666", "l": "MDM2 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213239", "l": "Formation of MHC II alpha beta heterodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989774", "l": "Expression of AGT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65946", "l": "3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine => AH2 + CTP + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30078", "l": "CMP + H2O <=> cytosine + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009046", "l": "zinc D-Ala-D-Ala carboxypeptidase activity", "d": ["Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21246", "l": "an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine => an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635842", "l": "ULK3 phosphorylates GLI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707516", "l": "FeHM dissociates from MetHb (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3221982", "l": "BANP binds TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19275", "l": "N-acetylneuraminate + phosphate => H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28946", "l": "glycine betaine(in) <=> glycine betaine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419011", "l": "Transhomodimerization of Nectins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102954", "l": "dalcochinase activity", "d": ["Catalysis of the reaction: dalcochinin-8'-O-beta-glucoside + H2O <=> dalcochinin + D-glucopyranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10393", "l": "(E)-cinnamyl alcohol + NADP(+) => (E)-cinnamaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797554", "l": "ABP1 binds SHANK proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57960", "l": "dimethyl sulfide + H(+) + NADH + O2 = dimethyl sulfoxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730872", "l": "Activation of Calcineurin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050228", "l": "pterin deaminase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxypteridine + H2O = 2,4-dihydroxypteridine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66874", "l": "9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004845", "l": "uracil phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445124", "l": "Patched binds Smoothened (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785607", "l": "FANCM binds FAAP24 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784735", "l": "PCSK9:LDLR bind to Clathrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-419490", "l": "Binding of ATP to P2X receptors (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39037", "l": "an omega-oxo fatty acid + H(+) + NADH => an omega-hydroxy fatty acid + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678925", "l": "NR3C1 binds NR3C1 agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15907", "l": "AH2 + cyclohexane-1,3-dione => 3-hydroxycyclohexanone + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61848", "l": "cholesterol + UDP-alpha-D-glucose = cholesteryl 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52352", "l": "(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140822", "l": "NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of ADP-ribose groups to the glutamate-35 residue of the N-terminal tail of histone H2B (or an equivalent residue)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140214", "l": "TP53 stimulates PMAIP1 (NOXA) expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466391", "l": "NRF1:p-PPARGC1A, NRF2 bind the TFAM promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72943", "l": "2 Na(+)(out) + pyruvate(out) = 2 Na(+)(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191784", "l": "snRNA Cap hypermethylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.24", "l": "\"rhamnogalacturonan exolyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75974", "l": "NADP(+) + neomorphine <=> H(+) + NADPH + neomorphinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761166", "l": "Expression of LHX1 in intermediate mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24536", "l": "L-tryptophan + O2 = N-formyl-L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382056", "l": "Crk binds to the active PDGF receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202443", "l": "Oligomerization of CARMA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416530", "l": "FFAR1:FFAR1 ligands activates Gq (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13990", "l": "alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036487", "l": "nitric-oxide synthase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of nitric oxide synthase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45267", "l": "(9Z,12Z)-octadecadienoate(out) <=> (9Z,12Z)-octadecadienoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44835", "l": "(R)-carnitine + tetradecanoyl-CoA <=> CoA + O-tetradecanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683888", "l": "LMCD1 binds GATA6, sequestering it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3899291", "l": "SUMOylation of EP300 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050509", "l": "N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102571", "l": "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity", "d": ["Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [glycoprotein]-(L-serine/L-threonine)."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015150", "l": "fucose transmembrane transporter activity", "d": ["Enables the transfer of fucose from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60405", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37893", "l": "15-demethylaclacinomycin T + methanol => aclacinomycin T + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18119", "l": "H2O + L-dopaquinone => L-tyrosine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19799", "l": "1D-myo-inositol 1,4-bisphosphate + phosphate => 1D-myo-inositol 1,4,5-trisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36463", "l": "glycyl-L-glutamate + H2O = glycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5622134", "l": "CRABP1 binds atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68150", "l": "(2R)-octan-2-ol + NADP(+) => 2-octanone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17167", "l": "diphosphate + dTDP-D-galactose => alpha-D-galactose 1-phosphate + dTTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12835", "l": "a carboxylate + D-glutamate => an N-acyl-D-glutamate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73437", "l": "H(+) + H2O + ladanein + oxidized [NADPH--hemoprotein reductase] => apigenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35018", "l": "riboflavin(in) <=> riboflavin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49626", "l": "ADP + D-erythritol 1-phosphate + H(+) => ATP + erythritol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62961", "l": "7-dehydrocholesterol(in) => 7-dehydrocholesterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55366", "l": "all-trans-nonaprenyl diphosphate + 6 diphosphate => (2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12082", "l": "3-oxobutanoyl-[ACP] + CO2 + CoA => acetyl-CoA + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0044683", "l": "methylthiol:coenzyme M methyltransferase activity", "d": ["Catalysis of the overall reaction: methyl-Co(III) methylated-thiol-specific corrinoid protein + coenzyme M = Co(I) methylated--thiol-specific corrinoid protein + methyl-CoM."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61202", "l": "CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71566", "l": "5-aminomethyl-dUMP in DNA + acetyl-CoA <=> 5-acetylaminomethyl-dUMP in DNA + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15345", "l": "ATP + L-arginine + L-tyrosine = AMP + diphosphate + H(+) + L-tyrosyl-L-arginine", "d": []}, {"i": "EC:6.3.2.24", "l": "\"tyrosine--arginine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11751", "l": "fluoroacetaldehyde + L-threonine <=> 4-fluoro-L-threonine + acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74902", "l": "(2E)-2-butenoate + ATP + holo-[ACP] <=> (2E)-butenoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.-", "l": "\"In ketonic substances\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34026", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) <=> (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57792", "l": "3,4-dinitrotoluene + NADH + O2 = 4-methyl-6-nitrocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30651", "l": "2 H2O + O2 + urate = allantoin + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102641", "l": "(R)-lactaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-propane-1,2-diol + NADP <=> (R)-lactaldehyde + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162657", "l": "Inactivation of Myt1 kinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102953", "l": "hypoglycin A gamma-glutamyl transpeptidase activity", "d": ["Catalysis of the reaction: glutathionate + hypoglycin A = L-cysteinylglycine + hypoglycin B."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30053", "l": "fluoride + glycolate + H(+) => fluoroacetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111238", "l": "Formation of ADAR2  homodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34543", "l": "N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP", "d": []}, {"i": "EC:2.4.1.291", "l": "\"N-acetylgalactosamine-N,N'-diacetylbacillosaminyl-diphospho-undecaprenol 4-alpha-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299478", "l": "MPP cleaves targeting peptide (presequence) of matrix precursors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64565", "l": "8-epi-ilicicolin H => ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10662", "l": "D-seryl-[protein] => L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39611", "l": "3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38019", "l": "(9Z)-octadecenoyl-CoA + 1-decanoylglycerol = 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940100", "l": "CDK1 phosphorylates VCPIP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41301", "l": "(9Z)-octadecenoate + sphing-4-enine => H2O + N-(9Z-octadecenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57670", "l": "(+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61397", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004174", "l": "electron-transferring-flavoprotein dehydrogenase activity", "d": ["Catalysis of the reaction: a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H+ + oxidized [electron-transfer flavoprotein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647631", "l": "GSDMD (1-275) binds PIPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0097625", "l": "low-affinity basic amino acid transmembrane transporter activity", "d": ["Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805205", "l": "GPR35 binds kynurenic acid (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44446", "l": "a fatty acid + a monoacylglycerol + H(+) => a 1,2-diacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034874", "l": "thioacetamide S-oxide S-oxygenase activity", "d": ["Catalysis of the reaction: thioacetamide S-oxide + O2 + 2 H+ + 2 e- = thioacetamide S,S-dioxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35823", "l": "5,6,7,8-tetrahydromethanopterin + NAD(+) = 7,8-dihydromethanopterin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358789", "l": "Self-ubiquitination of RNF41 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030549", "l": "acetylcholine receptor activator activity", "d": ["Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008868", "l": "galactitol-1-phosphate 5-dehydrogenase activity", "d": ["Catalysis of the reaction: galactitol-1-phosphate + NAD+ = D-tagatose 6-phosphate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68841", "l": "(2Z,6E)-farnesyl diphosphate => (6R,7S)-2,2,6-trimethyl-10-methylenebicyclo[5.4.0]undec-1(11)-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40899", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62338", "l": "adenosine 3'-diphosphate,5'-phosphate + AMP + H(+) => AMP + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29037", "l": "ADP + H(+) + L-glutamate(in) + phosphate => ATP + H2O + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38635", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19363", "l": "(2E,6E)-farnesyl diphosphate + diphosphate => (2E)-geranyl diphosphate + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166726", "l": "Activation of MASPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471354", "l": "HNP1-3 bind gp120 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8980691", "l": "RHOA GEFs activate RHOA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35131", "l": "H(+)(out) + L-alanyl-L-glutamate(out) = H(+)(in) + L-alanyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59673", "l": "D-maltotriose + O2 => D-maltotriono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611751", "l": "β1,2-agonists bind ADRB1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41772", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) = CMP + ganglioside GQ1b (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043802", "l": "hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity", "d": ["Catalysis of the reaction: 2 L-glutamine + 2 ATP + 2 H2O + hydrogenobyrinate = 2 L-glutamate + 2 ADP + 4 H+ + hydrogenobyrinate a,c-diamide + 2 phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24702", "l": "NAD(+) + UDP-alpha-D-glucuronate = CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose", "d": []}, {"i": "EC:1.1.1.305", "l": "\"UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68441", "l": "beta-cryptoxanthin + O2 => (3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17731", "l": "a cholesterol ester + CoA => an acyl-CoA + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28879", "l": "H(+)(in) + L-tryptophan(in) = H(+)(out) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22270", "l": "ADP + H(+) + streptomycin 6-phosphate => ATP + streptomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2562526", "l": "PLK1 phosphorylates OPTN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23446", "l": "H(+) + NADH + pyruvate => (S)-lactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.349248930891576", "identifiers": [{"i": "GO:0015370", "l": "solute:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in)."]}, {"i": "REACT:R-HSA-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73811", "l": "L-proline(in) = L-proline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25680", "l": "AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys) => ATP + O-phospho-L-serine + tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781899", "l": "USP13 binds SIAH2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008421", "l": "long-chain fatty-acyl-glutamate deacylase activity", "d": ["Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32091", "l": "3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine = dTDP + erythromycin D + H(+)", "d": []}, {"i": "EC:2.4.1.278", "l": "\"3-alpha-mycarosylerythronolide B desosaminyl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73235", "l": "2,6-dichlorobenzoquinone + H2O = 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939204", "l": "ESTG binds ESR1:chaperone complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32566", "l": "(2E)-geranyl diphosphate <=> alpha-terpinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37740", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64959", "l": "dTTP + 2 H2O <=> dTMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210294", "l": "Interaction of PECAM-1 and SHP-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45724", "l": "(E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664976", "l": "Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61407", "l": "ATP + N-(D-ribulosyl)-cadaverine <=> ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49669", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate => deoxyviolaceinate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654515", "l": "KAL1 binds HS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13628", "l": "A + H2O + N(6)-dimethylallyladenine <=> 3-methyl-2-butenal + adenine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33286", "l": "2-hydroxycyclohexan-1-one + NADPH + O2 <=> 6-oxohexanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34475", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate", "d": []}, {"i": "EC:2.5.1.32", "l": "\"15-cis-phytoene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51935", "l": "2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite <=> 2 Fe(II)-[cytochrome c3] + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12008", "l": "[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.11.16", "l": "\"[G-protein-coupled receptor] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804099", "l": "HMGB1 binds LTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879909", "l": "Activation of STAT5a/b by JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20277", "l": "acetyl-CoA + an N-hydroxyarylamine = an N-acetoxyarylamine + CoA", "d": []}, {"i": "EC:2.3.1.118", "l": "\"N-hydroxyarylamine O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674385", "l": "p-T,Y MAPKs dimerize (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65727", "l": "2-oxoglutarate + O2 + pentyl sulfate <=> CO2 + H(+) + pentanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201669", "l": "Beta-catenin translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19952", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate <=> 7,8-dihydropteroate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322422", "l": "Beta-catenin recruits SMARCA4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43064", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate = holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate", "d": []}, {"i": "EC:2.3.1.238", "l": "\"monacolin J acid methylbutanoate transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047042", "l": "androsterone dehydrogenase (B-specific) activity", "d": ["Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626681", "l": "Recruitment of transition zone proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60194", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36277", "l": "3-methylxanthine + formaldehyde + H2O + NADP(+) => H(+) + NADPH + O2 + theophylline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950782", "l": "p-STAT1 binds p-STAT3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74059", "l": "PDE6 hydrolyses cGMP to GMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004739", "l": "pyruvate dehydrogenase (acetyl-transferring) activity", "d": ["Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69761", "l": "2 H(+) + NADH + nonanoate => H2O + NAD(+) + nonanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12807", "l": "(S)-cis-N-methylcanadine + S-adenosyl-L-homocysteine => (S)-canadine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19828", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-aristolochene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008829", "l": "dCTP deaminase activity", "d": ["Catalysis of the reaction: dCTP + H2O = dUTP + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53579", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1912372", "l": "Fringe-modified Pre-NOTCH is cleaved by FURIN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139909", "l": "Translocation of BMF to mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20163", "l": "myo-inositol + raffinose => alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43633", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) => an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803719", "l": "TP53 binds ZNF385A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67519", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29522", "l": "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9726875", "l": "HCNs:cAMP bind SNIs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28137", "l": "(2S)-hesperidin + H2O <=> (2S)-hesperetin + rutinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65433", "l": "a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805981", "l": "HMGB1 release from cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22972", "l": "butanal + CoA + NADP(+) = butanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011748", "l": "IL9R binds JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0050354", "l": "triokinase activity", "d": ["Catalysis of the reaction: D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34970", "l": "sn-glycerol 3-phosphate(in) <=> sn-glycerol 3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650165", "l": "ASIC trimers bind H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034796", "l": "adipate-CoA ligase activity", "d": ["Catalysis of the reaction: adipate + CoASH = adipyl-CoA + OH-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13747", "l": "microthecin => ascopyrone M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022065", "l": "DSPGs are secreted (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32406", "l": "(1R,2S,4R)-neodihydrocarveol + NAD(+) <=> (1R,4R)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018460", "l": "cyclohexanol dehydrogenase activity", "d": ["Catalysis of the reaction: cyclohexanol + NAD+ = cyclohexanone + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11155", "l": "5-pyridoxate + NADPH + O2 <=> 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11328", "l": "dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate", "d": []}, {"i": "EC:2.5.1.28", "l": "\"dimethylallylcistransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45047", "l": "2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2 <=> 2 Fe(III)-[cytochrome c] + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.39", "l": "\"actinomycin lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604732", "l": "Autocatalytic activation of proMMP13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19221", "l": "2 formaldehyde + H2O = formate + H(+) + methanol", "d": []}, {"i": "EC:1.2.98.1", "l": "\"formaldehyde dismutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192123", "l": "CYP27A1 27-hydroxylates CHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733207", "l": "p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13549", "l": "beta-L-fucose 1-phosphate + GTP + H(+) = diphosphate + GDP-beta-L-fucose", "d": []}, {"i": "EC:2.7.7.30", "l": "\"fucose-1-phosphate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59467", "l": "NADP(+) + octadecan-1-ol <=> H(+) + NADPH + octadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59280", "l": "L-asparagine = D-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803988", "l": "N2O3 enters bacteria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24086", "l": "all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31446", "l": "ATP + D-sedoheptulose 7-phosphate <=> ADP + D-sedoheptulose 1,7-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0005368", "l": "taurine transmembrane transporter activity", "d": ["Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17951", "l": "CO + H(+) + N-formylanthranilate => 3-hydroxy-1H-quinolin-4-one + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450551", "l": "AUF1 binds translation and heat shock proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62155", "l": "dGMP + dTTP <=> dGDP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.36", "l": "\"trihydroxypterocarpan dimethylallyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446391", "l": "Formation of the PINCH-ILK-parvin complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58733", "l": "5-methyl-CTP + H2O => 5-methyl-CMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16222", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912727", "l": "CBL binds VAV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66339", "l": "L-glutamate(out) <=> L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793666", "l": "MDM2 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690196", "l": "USP8 deubiquitinates RNF128 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53203", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450802", "l": "FZ and VANG bind to STAN homodimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050356", "l": "tropine dehydrogenase activity", "d": ["Catalysis of the reaction: NADP+ + tropine = H+ + NADPH + tropinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72625", "l": "a 1,2-diacyl-sn-glycerol + inositol-1-phospho-N-(2-hydroxy-fatty acyl)-sphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxy-fatty acyl)-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047144", "l": "2-acylglycerol-3-phosphate O-acyltransferase activity", "d": ["Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805035", "l": "TP53 binds STK11 and NUAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2002440", "l": "Removal of fibrillar collagen C-propeptides (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102083", "l": "7,8-dihydromonapterin aldolase activity", "d": ["Catalysis of the reaction: 7,8-dihydromonapterin <=> glycolaldehyde + 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48058", "l": "beta-D-glucosylceramide + D-galactose => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033810", "l": "anthocyanin 5-O-glucoside 6'''-O-malonyltransferase activity", "d": ["Catalysis of the reaction: malonyl-CoA + pelargonidin 3-O-(6-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside = CoA + 4'''-demalonylsalvianin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250217", "l": "ARL2:GTP binds ARL2BP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737780", "l": "MTTP binds lomitapide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070733", "l": "protein adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to L-serine, L-threonine, and L-tyrosine residues in target proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205306", "l": "Interaction of SHP1 and KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48669", "l": "20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14977", "l": "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate", "d": []}, {"i": "EC:5.5.1.5", "l": "\"carboxy-cis,cis-muconate cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66488", "l": "quillate + UDP-alpha-D-glucose = quillaic acid 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805546", "l": "Keratin type I binds keratin type II (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9674095", "l": "PDGFRs bind type II TKI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35616", "l": "hydroxyacetone + NAD(+) => H(+) + methylglyoxal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614460", "l": "Dimerization of procollagen type VI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654167", "l": "Activated FGFR1 binds PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682388", "l": "Autophagosome maturation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0001163", "l": "RNA polymerase I transcription regulatory region sequence-specific DNA binding", "d": ["Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42606", "l": "(9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+) => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37832", "l": "(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 => 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51859", "l": "(E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47757", "l": "guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44793", "l": "2-demethylmenaquinol-12 + S-adenosyl-L-methionine => H(+) + menaquinol-12 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51972", "l": "an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45652", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426489", "l": "RISC binds inexactly matching target RNAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807008", "l": "PTPRJ dephosphorylates MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004822", "l": "isoleucine-tRNA ligase activity", "d": ["Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072585", "l": "xanthosine nucleotidase activity", "d": ["Catalysis of the reaction: xanthosine + H2O = D-ribose + xanthine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46210", "l": "AMP + diphosphate + eicosanoyl-CoA => ATP + CoA + eicosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51103", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701810", "l": "MECP2 binds the STAT5A gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39669", "l": "a ketone + reduced coenzyme F420-(gamma-L-Glu)(n) => a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13026", "l": "3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] => 3-methyl-(2E)-glutaconyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003693", "l": "P-element binding", "d": ["Binding to a P-element, a class of Drosophila transposon responsible for hybrid dysgenesis."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033877", "l": "succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity", "d": ["Catalysis of the reaction: (R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047025", "l": "3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity", "d": ["Catalysis of the reaction: NAD+ + OH-acyl-[acyl-carrier protein] = NADH + H+ + B-ketoacyl-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12117", "l": "A + H2 => AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33706", "l": "(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA <=> CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196026", "l": "Dab2 is recruited to the junctional plaques (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35042", "l": "spermidine(in) <=> spermidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10162", "l": "H(+) + keto-L-sorbose + NADH => L-iditol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372852", "l": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63108", "l": "16-hydroxy-ilicicolin A epoxide = ascofuranol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.315", "l": "\"diglucosyl diacylglycerol synthase (1,6-linking)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35364", "l": "(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH => isopentadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40542", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624239", "l": "Defective SLC17A5 does not cotransport Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49685", "l": "H(+) + NADH + O2 + resorcinol => benzene-1,2,4-triol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58723", "l": "(S)-nicotine + NADPH + O2 <=> H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264865", "l": "Caspase-mediated cleavage of Lamin A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47740", "l": "1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate = CO2 + demethylphylloquinone + diphosphate", "d": []}, {"i": "EC:2.5.1.130", "l": "\"2-carboxy-1,4-naphthoquinone phytyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22900", "l": "(R)-acetoin + NAD(+) = diacetyl + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.303", "l": "\"diacetyl reductase [(R)-acetoin forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607023", "l": "factor IXa associates with cell membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797974", "l": "LRRTMs bind NRXNs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34988", "l": "(S)-lactate(in) => (S)-lactate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48495", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose <=> 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73372", "l": "(R)-pantothenate(out) + 2 Na(+)(out) => (R)-pantothenate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51050", "l": "AH2 + androst-4-ene-3,17-dione => 5alpha-androstan-3,17-dione + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53990", "l": "L-threonyl-[myosin light chain] + phosphate => H2O + O-phospho-L-threonyl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74723", "l": "Endosome acidification (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64291", "l": "2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase] <=> cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42473", "l": "dibenzo-p-dioxin + NADH + O2 => 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112430", "l": "Formation of P-TEFb complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44890", "l": "1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72920", "l": "4-O-demethylbarbatate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21669", "l": "ATP + H2O + sn-glycerol 3-phosphate(out) => ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73387", "l": "H(+)(in) + malonate(out) + phosphate(in) = H(+)(out) + malonate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5227009", "l": "ABCF1 binds EIF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9656244", "l": "DRD2 binds DA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26180", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate", "d": []}, {"i": "EC:3.5.1.103", "l": "\"N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004119", "l": "cGMP-inhibited cyclic-nucleotide phosphodiesterase activity", "d": ["Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6802973", "l": "PLK3 phosphorylates CDC25C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110319", "l": "Elongation by POLH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454928", "l": "ABCG4 may mediate cholesterol efflux (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928615", "l": "EFNBs bind SFKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19496", "l": "D-cellobiose + phosphate <=> alpha-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015310", "l": "benomyl:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030697", "l": "S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine at position U54 of a transfer RNA. This occurs in most Gram-negative bacteria, some archae, and eukaryotes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47586", "l": "ganglioside GT1c (d18:1(4E)) + H(+) + UDP => ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59911", "l": "H2O + hexanal + NADP(+) <=> 2 H(+) + hexanoate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46183", "l": "2-methylbutanoate + ATP + CoA <=> 2-methylbutanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033709", "l": "D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity", "d": ["Catalysis of the reaction: D-arabinitol + NADP+ = D-ribulose + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70815", "l": "H(+)(in) + L-histidine(in) + L-ornithine(out) = H(+)(out) + L-histidine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43928", "l": "pregn-5-ene-3,20-dione = progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19664", "l": "D-mannitol 1-phosphate + NAD(+) <=> beta-D-fructose 6-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69975", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] = (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046175", "l": "Further sulfation on galactose residues produces KSPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033460", "l": "GAG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GAG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354066", "l": "Translocation of PTK2 to Focal complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43297", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30855", "l": "dammarenediol-II = (S)-2,3-epoxysqualene + H2O", "d": []}, {"i": "EC:4.2.1.125", "l": "\"dammarenediol II synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74574", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] <=> N(alpha)-acetyl-L-methionine + N-terminal L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19864", "l": "a 16alpha-hydroxysteroid + NAD(+) <=> a 16-oxosteroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296309", "l": "HCAR3 binds HCAR3 ligands (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867047", "l": "PTPN3 dephosphorylates EPS15 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48513", "l": "ATP + H2O + phosphinate(out) => ADP + H(+) + phosphate + phosphinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728747", "l": "GNAT3 exchanges GDP for GTP in TAS2R:bitter compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37745", "l": "phosphate + prenyl-FMNH2 => dimethylallyl phosphate + FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65329", "l": "A + chrodrimanin F => AH2 + chrodrimanin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58052", "l": "(2-aminoethyl)phosphonate + acetyl-CoA = (2-acetamidoethyl)phosphonate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70977", "l": "3-sulfino-L-alanine(in) + L-aspartate(out) => 3-sulfino-L-alanine(out) + L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48615", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18516", "l": "D-mannitol + O2 <=> D-mannose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39566", "l": "(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH <=> (23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987223", "l": "IL10RB binds TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617408", "l": "GLI3R binds the GLI1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9676255", "l": "Formation of the MLL2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74581", "l": "N-acetyl-L-cysteine + N-terminal L-aspartyl-[protein] => H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31863", "l": "(S)-2,3-epoxysqualene = friedelin", "d": []}, {"i": "EC:5.4.99.50", "l": "\"friedelin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14092", "l": "2-oxoglutarate + glycine <=> glyoxylate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75891", "l": "Abortive Initiation After Second Transition (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47537", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isochenodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75028", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + 9-hydroxy-octadecanoate => 9-(9Z-hexadecenoyloxy)-octadecanoate + di-(9Z)-hexadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38485", "l": "a 2-acylglycerol + a fatty acid + H(+) => a 2,3-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54923", "l": "13-cis-retinol + NADP(+) <=> 13-cis-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61074", "l": "(-)-(R)-19-O-acetyltabersonine + CoA => (-)-(R)-19-hydroxytabersonine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74608", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-galactosamine(out) => UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-galactosamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031734", "l": "CCR9 chemokine receptor binding", "d": ["Binding to a CCR9 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25879", "l": "L-aspartate + O2 <=> H2O2 + iminosuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432054", "l": "Aquaporin-1 passively transports water out of cell (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2514865", "l": "cGMP dissociates from CNG channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730892", "l": "Recruitment of VAV to p-SLP-76 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928578", "l": "EPH receptors autophosphorylate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.364943696244829", "identifiers": [{"i": "GO:0044877", "l": "protein-containing complex binding", "d": ["Binding to a macromolecular complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0141056", "l": "histone H4 ubiquitin ligase activity", "d": ["Catalysis of the transfer of ubiquitin to a histone H4 substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15522", "l": "N-terminal glycyl-[protein] + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoylglycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17580", "l": "ADP-D-glycero-beta-D-manno-heptose <=> ADP-L-glycero-beta-D-manno-heptose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73782", "l": "dimethylallyl diphosphate + preechinulin <=> diphosphate + tardioxopiperazine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15457", "l": "cis-1,2-dihydrobenzene-1,2-diol + NAD(+) = catechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36036", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45297", "l": "a sphingosylphosphocholine + H2O => a sphingoid base + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111970", "l": "PKC phosphorylates GRK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63779", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68335", "l": "(R)-4'-phosphopantothenate + H2O <=> (R)-pantothenate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.137", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56548", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649735", "l": "Intrinsic nucleotide exchange on RAS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190682", "l": "Connexin synthesis (generic) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52336", "l": "a long-chain fatty acid + ATP + H(+) = a long-chain fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15559", "l": "ADP + H(+) + Ni(2+)(in) + phosphate => ATP + H2O + Ni(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866321", "l": "VLDL binds APOC1 and APOC4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034898", "l": "hexadecyltrimethylammonium chloride monooxygenase activity", "d": ["Catalysis of the reaction: hexadecyltrimethylammonium chloride + NAD(P)H + H+ + O2 = trimethylamine + hexadecanal + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209903", "l": "Noradrenaline is converted to adrenaline (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73890", "l": "chloride(out) + Na(+)(out) <=> chloride(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71308", "l": "chloride(out) + L-valine(out) + 2 Na(+)(out) => chloride(in) + L-valine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168459", "l": "Lyn activates ERK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55972", "l": "acetyl-CoA + ethanol = CoA + ethyl acetate", "d": []}, {"i": "EC:2.3.1.268", "l": "\"ethanol O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72424", "l": "(E)-4-coumaroyl-AMP + CoA => (E)-4-coumaroyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008076", "l": "WWP1 polyubiquitinates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421478", "l": "coproporphyrinogen III + 2 O2 => protoporphyrinogen IX + 2 H2O2 + 2 CO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51772", "l": "dimethylallyl diphosphate + phlorisobutanophenone = 4-prenylphlorisobutanophenone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047923", "l": "gentisate decarboxylase activity", "d": ["Catalysis of the reaction: 2,5-dihydroxybenzoate + H+ = CO2 + hydroquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25380", "l": "2-hydroxy-3-methylhexadecanoyl-CoA => 2-methylpentadecanal + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58088", "l": "1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O = (7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11294", "l": "H2O2 + rifamycin O => 2 H(+) + O2 + rifamycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70971", "l": "citrate <=> isocitrate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2484822", "l": "Kinetochore assembly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033409", "l": "UAU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UAU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55553", "l": "N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033811", "l": "flavonol-3-O-triglucoside O-coumaroyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14779", "l": "IMP + NH4(+) => AMP + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0004662", "l": "CAAX-protein geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17412", "l": "(S)-coclaurine + S-adenosyl-L-methionine <=> (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186785", "l": "PDGF-AA clevage by Furin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58208", "l": "A + dihydroalstonine = AH2 + alstonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50756", "l": "NADP(+) + reduced [flavodoxin] = 2 H(+) + NADPH + oxidized [flavodoxin]", "d": []}, {"i": "EC:1.19.1.1", "l": "\"flavodoxin--NADP(+) reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51504", "l": "a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose = a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.360", "l": "\"2-hydroxyflavanone C-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209973", "l": "Tyrosine is diiodinated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10994", "l": "glyoxylate + H(+) + NADPH => glycolate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20245", "l": "ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate", "d": []}, {"i": "EC:2.7.7.47", "l": "\"streptomycin 3''-adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873927", "l": "Release of STAT1 dimer from active receptor unit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14384", "l": "4-guanidinobutanal + H2O + NAD(+) <=> 4-guanidinobutanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0034327", "l": "hexanoyltransferase activity", "d": ["Catalysis of the transfer of a hexanoyl (CH3-[CH2]4-CO-) group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62622", "l": "[thioredoxin]-disulfide + an alcohol + H2O => [thioredoxin]-dithiol + a hydroperoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19401", "l": "methanol + NAD(+) = formaldehyde + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.244", "l": "\"methanol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26413", "l": "H2O + N-acetyl-D-muramate 6-phosphate <=> (R)-lactate + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862300", "l": "LYZ binds bacterial peptidoglycan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757954", "l": "N4BP1 binds IKBKG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017162", "l": "aryl hydrocarbon receptor binding", "d": ["Binding to an aryl hydrocarbon receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16430", "l": "ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32621", "l": "H(+) + NADPH + sepiapterin => L-threo-7,8-dihydrobiopterin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430096", "l": "GP1b-IX-V binds filamin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017491", "l": "RHOJ GEFs activate RHOJ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61563", "l": "gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167415", "l": "G-protein alpha subunit is inactivated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008959", "l": "phosphate acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69216", "l": "(omega-1)-methyl-(3R)-hydroxy-fatty acyl-CoA + NADP(+) = (omega-1)-methyl-3-oxo-fatty acyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854303", "l": "TBC1D11 binds RAB6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.62", "l": "\"caspase-9\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875661", "l": "GGA3 associates with activated MET receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052770", "l": "coenzyme F390-A hydrolase activity", "d": ["Catalysis of the reaction: coenzyme F390-A = AMP + coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669240", "l": "FLNA binds PAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62790", "l": "aurasperone B + 2 H2O + NADP(+) => 2 fonsecin B + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77068", "l": "Activation of GT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74467", "l": "a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + H2O = a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010091", "l": "APP translocates from plasma membrane to endosome lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696958", "l": "USP44 deubiquitinates CDC20 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28791", "l": "5,6-dihydrothymine + NAD(+) = H(+) + NADH + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450088", "l": "GLUT1 tetramer binds 4xATP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013110", "l": "RHOC binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351913", "l": "Caspase-mediated cleavage of TJP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28795", "l": "2 a Fe(II)-siderophore + H(+) + NADP(+) = 2 a Fe(III)-siderophore + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51061", "l": "5alpha-androst-1-ene-3,17-dione + A => AH2 + androsta-1,4-diene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693761", "l": "FA2H hydroxylates CERA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2534096", "l": "METAP1/2 demethylates GNAT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793628", "l": "Cipro is imported by organic cation transporters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32019", "l": "(2E,6E)-farnesyl diphosphate = beta-cubebene + diphosphate", "d": []}, {"i": "EC:4.2.3.128", "l": "\"beta-cubebene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952128", "l": "RUNX3 binds TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11489", "l": "all-trans-retinol + an acyl-CoA => an all-trans-retinyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60393", "l": "Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O => Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53319", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16792", "l": "a (2S)-2-hydroxycarboxylate + O2 <=> a 2-oxocarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607756", "l": "TRAF6 oligomer autoubiquitinates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39288", "l": "Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + trimethylamine => dimethylamine + methyl-Co(III)-[trimethylamine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49946", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52185", "l": "(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450348", "l": "Activated human JNKs migrate to nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25995", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-epi-isozizaene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047394", "l": "glycerophosphoinositol inositolphosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.75", "l": "\"phosphoethanolamine/phosphocholine phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54465", "l": "1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52795", "l": "chlorophyllide a + 2 H(+) <=> Mg(2+) + pheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755303", "l": "26S proteasome degrades HIFalpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53020", "l": "a plastoquinone + an L-alpha-amino acid + H2O = a 2-oxocarboxylate + a plastoquinol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15503", "l": "2-oxoglutarate + H(+) + L-glutamine + NADPH => 2 L-glutamate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12979", "l": "creatine + phosphate => H2O + N-phosphocreatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19029", "l": "3 H(+) + H2O + urea-1-carboxylate = 2 CO2 + 2 NH4(+)", "d": []}, {"i": "EC:3.5.1.54", "l": "\"allophanate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45559", "l": "H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209573", "l": "p75NTR:NgR complex interacts with the axonal inhibitor LINGO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46641", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH => 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754964", "l": "ADA deamidates RBV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454239", "l": "Phosphorylation of SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71050", "l": "Trimerization of the FASL:FAS receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64623", "l": "(E)-sinapyl alcohol + acetyl-CoA <=> (E)-sinapoyl actetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612980", "l": "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52061", "l": "12-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75754", "l": "(9Z)-octadecenoate + H2O <=> 10-hydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047000", "l": "2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + NADP+ = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28249", "l": "(R)-pantoate + ATP <=> (R)-4-phosphopantoate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55841", "l": "calcidiol + UDP-alpha-D-glucuronate => calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69189", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate => ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13336", "l": "beta-D-fructose 2,6-bisphosphate + H2O <=> beta-D-fructose 2-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102864", "l": "1-18:3-2-18:2-phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40444", "l": "6-deoxy-6-sulfo-D-fructose + ATP => 6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41671", "l": "dihydrochelirubine + NADP(+) <=> chelirubine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65222", "l": "catechol + H(+) + NADPH => (1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004031", "l": "aldehyde oxidase activity", "d": ["Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433454", "l": "Phosphorylation of GAB2 by SFKs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56278", "l": "3'-L-prolyl-AMP + diphosphate => ATP + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20687", "l": "H(+) + keto-D-tagatose + NADH => galactitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047107", "l": "gamma-guanidinobutyraldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 4-guanidinobutanal + H2O + NAD+ = 4-guanidinobutanoate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59438", "l": "4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate => 4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700175", "l": "Active ALK phosphorylates SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013438", "l": "RHOD binds effectors at the endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37985", "l": "2,3-dimethyl-6-phytylbenzene-1,4-diol => gamma-tocopherol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17433", "l": "A + choline = AH2 + betaine aldehyde", "d": []}, {"i": "EC:1.1.99.1", "l": "\"choline dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13317", "l": "(2R,3R)-tartrate + H(+) = (R)-glycerate + CO2", "d": []}, {"i": "EC:4.1.1.73", "l": "\"tartrate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865276", "l": "PDGF-AB clevage by Furin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20063", "l": "a ribonucleoside 5'-diphosphate + dCMP + H(+) => 2'-deoxycytidine + a ribonucleoside 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43713", "l": "ATP + dodecanoate + H(+) => diphosphate + dodecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67782", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102093", "l": "acrylate:acyl-coA CoA transferase activity", "d": ["Catalysis of the reaction: acryloyl-CoA + H2O <=> acrylate + coenzyme A + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043135", "l": "5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity", "d": ["Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + H2O = ribose 1,5 bisphosphate + phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199910", "l": "MSK1 activates ATF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18811", "l": "aminomalonate + pyruvate => L-alanine + oxomalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70925", "l": "(R)-noradrenaline(in) + chloride(in) + Na(+)(in) => (R)-noradrenaline(out) + chloride(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23889", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine => [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54212", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683964", "l": "ATM phosphorylates EYA1-4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28492", "l": "H(+)(out) + K(+)(out) => H(+)(in) + K(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014293", "l": "RAC2 GDIs block activation of RAC2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193981", "l": "CYP21A2 oxidises 17HPROG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033520", "l": "TYSND1 cleaves TYSND1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72990", "l": "myo-inositol(out) + 2 Na(+)(out) <=> myo-inositol(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392748", "l": "L1 binds to AP-2 Clathrin complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54821", "l": "a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203567", "l": "palmitoylation of eNOS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21945", "l": "ATP + D-cellobiose => 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61822", "l": "epiandrosterone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000227", "l": "oxaloacetate secondary active transmembrane transporter activity", "d": ["Enables the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61115", "l": "(2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase] <=> (2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429415", "l": "SYK binds to integrin alphaIIb beta3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390593", "l": "ATP Hydrolysis By Myosin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19989", "l": "S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate", "d": []}, {"i": "EC:5.3.1.23", "l": "\"S-methyl-5-thioribose-1-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16256", "l": "(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) <=> H(+) + NADH + phenanthrene-3,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54001", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23671", "l": "apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433374", "l": "Processing of SCF isoform 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36548", "l": "octadecanoyl-CoA + sphinganine => CoA + H(+) + N-(octadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36770", "l": "2-hydroxytetracosenoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427337", "l": "MBD2 binds methylcytosine in chromatin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52697", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose => a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755303", "l": "26S proteasome degrades HIFalpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3785704", "l": "DSB inducing agents induce double strand DNA breaks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29730", "l": "ethane-1-sulfonate + FMNH2 + O2 <=> acetaldehyde + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0001056", "l": "RNA polymerase III activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."]}, {"i": "REACT:R-HSA-1964482", "l": "RNA polymerase III transcribes microbial dsDNA to dsRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19535", "l": "CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+) => 2 H(+) + 2 H2O + N(2)-succinyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67974", "l": "ADP + ecdysone 22-phosphate + H(+) => ATP + ecdysone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912353", "l": "Glucosylation of Pre-NOTCH by POGLUT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45790", "l": "1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA => (9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57702", "l": "5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine => a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005185", "l": "neurohypophyseal hormone activity", "d": ["The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55066", "l": "4-methylpentanoate + CoA + H(+) => 4-methylpentanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0003933", "l": "GTP cyclohydrolase activity", "d": ["Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.145", "l": "\"deoxynucleoside kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46612", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41755", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391934", "l": "DP2 receptor can bind PGD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12961", "l": "acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate", "d": []}, {"i": "EC:2.8.3.9", "l": "\"butyrate--acetoacetate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73185", "l": "ADP(out) + FAD(in) => ADP(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.23", "l": "\"lipopolysaccharide heptosyltransferase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48985", "l": "(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 => 2,4-dichlorophenol + CO2 + glyoxylate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102173", "l": "24-methylenecycloartanol 4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 24-methylenecycloartanol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56028", "l": "3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672817", "l": "Active MTORC1 binds the ULK1 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47516", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH = isochenodeoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58371", "l": "(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) <=> (2E,6Z)-nona-2,6-dienal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17730", "l": "an acyl-CoA + cholesterol => a cholesterol ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14081", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = D-glyceraldehyde 3-phosphate + indole", "d": []}, {"i": "EC:4.1.2.8", "l": "\"indole-3-glycerol-phosphate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39431", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102267", "l": "tRNA-dihydrouridine20b synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil20b in tRNA + NAD(P) = H+ + a uracil20b in tRNA + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987043", "l": "IL22RA1 binds JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38161", "l": "(2S,3R)-capreomycidine + H2O => (2S,3S)-hydroxyarginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29633", "l": "alpha-D-glucose + D-maltotriose => D-maltotetraose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40276", "l": "hexadecanedioyl-CoA + O2 => (2E)-hexadecenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50091", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45578", "l": "(2S)-methylsuccinyl-CoA => (2R)-ethylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451470", "l": "Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29712", "l": "cadaverine(in) + H(+)(in) => cadaverine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.120", "l": "\"L-fucono-1,5-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651942", "l": "Defective SLC35A1 does not exchange CMP-Neu5Ac for CMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24760", "l": "H(+) + L-dopa + NADH = 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)", "d": []}, {"i": "EC:4.3.1.22", "l": "\"3,4-dihydroxyphenylalanine reductive deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418172", "l": "F2R binds ARRB2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417890", "l": "P2Y5 receptor can bind to LPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654422", "l": "Activated FGFR4 binds FRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65194", "l": "berkeleytrione + 2 CO2 + H2O + 2 succinate => 2 2-oxoglutarate + 2 O2 + preaustinoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62939", "l": "H2O + N(4)-acetyl-2'-deoxycytidine <=> 2'-deoxycytidine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25523", "l": "an acyl-CoA + pseudotropine <=> CoA + H(+) + O-acylpseudotropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25340", "l": "isocyanate + NH4(+) => H(+) + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265545", "l": "NPC1L1-mediated phytosterol uptake (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1006169", "l": "Factor H binds host cell surface markers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381668", "l": "cAMP activates EPAC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5676229", "l": "WIPIs bind PI3P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59281", "l": "L-asparagine => D-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75765", "l": "10-hydroxy-(11E)-octadecenoate => (9E,11E)-octadecadienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60740", "l": "(S)-(-)-citronellal + H2O + NADP(+) = (S)-(-)-citronellate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61062", "l": "a neolactoside nLc4Cer + H(+) + UDP => beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218832", "l": "CDC42:GTP binds PAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75965", "l": "15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione => 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67793", "l": "ribonucleotidyl-uridine-RNA => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871260", "l": "YAP1 binds TEAD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034571", "l": "4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity", "d": ["Catalysis of the reaction: 4'-(2-hydroxyisopropyl)phenylurea + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + carbamic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48275", "l": "2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0008519", "l": "ammonium transmembrane transporter activity", "d": ["Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47468", "l": "(2E,4E)-tetradecadienoyl-CoA = (3E,5Z)-tetradecadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60090", "l": "a 4alpha-methyl-3-oxosteroid + CO2 + NADPH => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42002", "l": "H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51078", "l": "2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => 2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61060", "l": "beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose = a neolactoside nLc4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031758", "l": "Edg-5 sphingosine 1-phosphate receptor binding", "d": ["Binding to an Edg-5 sphingosine 1-phosphate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811412", "l": "Active ARF recruits coatomer to the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044020", "l": "histone H4R3 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to the arginine residue at position 3 of histone H4, producing histone H4R3me."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28375", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990444", "l": "F-box domain binding", "d": ["Binding to an F-box domain of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47869", "l": "di-(9Z)-octadecenoylglycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21039", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68615", "l": "H(+) + NADPH + prostaglandin E1 <=> NADP(+) + prostaglandin F1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53801", "l": "lithocholoyl-CoA + ursodeoxycholate => lithocholate + ursodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004400", "l": "histidinol-phosphate transaminase activity", "d": ["Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52954", "l": "lithocholoyl-24-O-(beta-D-glucuronate) + UDP => lithocholate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74272", "l": "an alpha-Kdo-(2->6)-lipid IVA + ATP => a 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65757", "l": "2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] => (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56079", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63315", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944229", "l": "Association of procollagen type IX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11487", "l": "a quinol + 2 Fe(III)-[cytochrome c](out) <=> a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28246", "l": "(R)-pantoate + ATP = (R)-4-phosphopantoate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.169", "l": "\"pantoate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56906", "l": "AMP + an acyl-CoA + H(+) => an acyl-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55985", "l": "(R)-mandelonitrile + UDP-alpha-D-glucose => (R)-prunasin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2984226", "l": "PLK1 phosphorylates NEK9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0150047", "l": "G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential", "d": ["G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809254", "l": "MTMR8 binds MTMR9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54754", "l": "dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => methanophenazine + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75864", "l": "all-trans-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-4-hydroxy-13,14-dihydroretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375155", "l": "Interaction of NCAM1 with agrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61682", "l": "AMP + diphosphate + L-cysteinyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43676", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617927", "l": "FOXO4 binds ATXN3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34905", "l": "glutathione disulfide + 3 H2O + selenodiglutathione => 4 glutathione + 2 H(+) + selenite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72779", "l": "chloride + FADH2 + O2 + ochratoxin B = FAD + 2 H2O + ochratoxin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24471", "l": "H(+) + N,N-dimethylaniline + NADPH + O2 <=> H2O + N,N-dimethylaniline N-oxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47123", "l": "docosanoate + glycine <=> H2O + N-docosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45516", "l": "phycocyanobilin-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426161", "l": "SREBP1A,2 binds the GGPS1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34539", "l": "S-adenosyl-L-methionine + tellurite = methanetellurite + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.265", "l": "\"tellurite methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.12.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23226", "l": "H(+) + O-beta-D-glucosyl-trans-zeatin + UDP => trans-zeatin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40657", "l": "(R)-malyl-CoA + succinate => (R)-malate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58538", "l": "CoA + H(+) + N-hexadecanoylglycine => glycine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64209", "l": "an N-(fatty acyl)-L-glutamine + H2O => a fatty acid + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68271", "l": "dUMP + formaldehyde + H(+) + NADPH <=> dTMP + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050609", "l": "phosphonate dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + phosphonate = 2 H+ + NADH + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033814", "l": "propanoyl-CoA C-acyltransferase activity", "d": ["Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26414", "l": "a secondary aliphatic amine + H2O + O2 = a primary amine + an aldehyde + H2O2", "d": []}, {"i": "EC:1.4.3.4", "l": "\"monoamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928624", "l": "EPHBs bind EFNBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53033", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26087", "l": "H2O + limonene 1,2-epoxide + NADP(+) => (4S)-limonene + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086087", "l": "voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17818", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62525", "l": "cytidine(839) in 12S rRNA + S-adenosyl-L-methionine => H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30208", "l": "H2O + methylamine + 2 oxidized [amicyanin] => formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004982", "l": "N-formyl peptide receptor activity", "d": ["Combining with an N-formyl peptide to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60629", "l": "AH2 + gluconapin + O2 => A + H2O + progoitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51817", "l": "ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out) => AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800793", "l": "PIDD1 translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71745", "l": "2-oxoglutarate(in) + hexanedioate(out) => 2-oxoglutarate(out) + hexanedioate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399939", "l": "Autophosphorylation of PAK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374919", "l": "Noradrenaline clearance from the synaptic cleft (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39510", "l": "3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75276", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (10R,11R)-epoxy-(9S)-hydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869683", "l": "oxPL binds LBP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110319", "l": "Elongation by POLH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18102", "l": "cis-1,2-dihydro-3-ethylcatechol + NAD(+) => 3-ethylcatechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191656", "l": "Closure of gap junction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814088", "l": "SYS1 binds AcM-ARFRP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51525", "l": "(S)-corytuberine + S-adenosyl-L-methionine => magnoflorine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656267", "l": "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2512800", "l": "SCARB1:ligand is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848939", "l": "PTK6 binds KHDRBS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67404", "l": "gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63441", "l": "(2R)-3-phosphoglycerate + GTP + H(+) => 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59819", "l": "a long-chain fatty acyl-CoA + a sterol <=> a sterol ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047417", "l": "N-carbamoyl-D-amino acid hydrolase activity", "d": ["Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59245", "l": "3''-O-acetyl-ADP-D-ribose + H2O => acetate + ADP-D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866941", "l": "MID1IP1 binds THRSP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50245", "l": "17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682026", "l": "MRN bound to shortened telomeres activates ATM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354066", "l": "Translocation of PTK2 to Focal complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45762", "l": "dTDP + H(+) + rhodomycin D => dTDP-beta-L-daunosamine + epsilon-rhodomycinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169719", "l": "Secreted CD14 binds LPS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67228", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA = (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61633", "l": "5-aminopentanal + H2O + NAD(+) => 5-aminopentanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047220", "l": "galactosylxylosylprotein 3-beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429157", "l": "ABCC4 accumulation of dense granule contents (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418858", "l": "RhoGTPase GEF's recruited to DCC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782895", "l": "TYW1:FMN:4Fe-4S  transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40337", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60504", "l": "1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114256", "l": "CYCS:APAF1 binds procaspase-9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2545253", "l": "Deacetylation of cohesin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74737", "l": "7,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + syringetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44539", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15151", "l": "H2O2 + pyridoxal 5'-phosphate => O2 + pyridoxine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0008093", "l": "cytoskeletal anchor activity", "d": ["The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42555", "l": "uridine(31) in tRNA <=> pseudouridine(31) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58023", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) <=> eupatolide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36746", "l": "heptadecasphing-4-enine + tetracosenoyl-CoA <=> CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33424", "l": "N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) => diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112396", "l": "Separation of elongating transcript from template (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50991", "l": "prostaglandin F2alpha(out) <=> prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874849", "l": "CREBRF binds CREB3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74543", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (E,E,E)-alpha-springene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38978", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67652", "l": "dADP + H2O = 2'-deoxyadenosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61757", "l": "stevioside + UDP-alpha-D-glucose => H(+) + rebaudioside A + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632670", "l": "CSNK1A1 phosphorylates SMO dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015254", "l": "glycerol channel activity", "d": ["Enables the facilitated diffusion of glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12206", "l": "3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801101", "l": "RABGGTA binds RABGGTB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615668", "l": "AKR1C3 reduces atRAL to atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10408", "l": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.200", "l": "\"exo-chitinase (non-reducing end)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39145", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56284", "l": "a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) = a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33969", "l": "3-maleylpyruvate + H(+) => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632648", "l": "SMURF1/2 ubiquitinates PTCH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38894", "l": "H2O + N-hexadecanoylsphing-4-enine <=> hexadecanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35749", "l": "7-epizingiberene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874979", "l": "ACBD3 binds GOLGB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41951", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate <=> [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72867", "l": "3',3',3'-cAAG + H2O = A[3'-5']pG[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090430", "l": "caffeoyl-CoA: alcohol caffeoyl transferase activity", "d": ["Catalysis of the reaction: caffeoyl-CoA + a saturated primary alcohol = an alkyl caffeate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64281", "l": "(S)-1-phenylethylamine + pyruvate => acetophenone + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49302", "l": "alpha-maltose 6'-phosphate(in) + L-histidyl-[protein] => D-maltose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004754", "l": "saccharopine dehydrogenase (NAD+, L-lysine-forming) activity", "d": ["Catalysis of the reaction: L-saccharopine + H2O + NAD+ = 2-oxoglutarate + L-lysine + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60236", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate", "d": []}, {"i": "EC:1.14.11.69", "l": "\"[histone H3]-trimethyl-L-lysine(36) demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53280", "l": "D-threose = D-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35606", "l": "beta-D-fructose 1-phosphate + H2O <=> D-fructose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938314", "l": "ENPPs hydrolyse CoA-SH to PPANT, PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31246", "l": "H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) <=> (4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73603", "l": "CMP(in) + CTP(out) = CMP(out) + CTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0000014", "l": "single-stranded DNA endodeoxyribonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67884", "l": "3'-phosphoadenylyl sulfate + dopamine = adenosine 3',5'-bisphosphate + dopamine 4-O-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25959", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) <=> 3-dehydroquinate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73718", "l": "UBF-1 Binds rDNA Promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193981", "l": "CYP21A2 oxidises 17HPROG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44315", "l": "1-tetradecanoylglycerol + H2O <=> glycerol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685956", "l": "3a is externalized together with membrane structures (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35315", "l": "H(+) + hexadecanoyl-CoA + malonyl-CoA = 3-oxooctadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62167", "l": "beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O <=> D-glucosamine + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58347", "l": "beta-D-glucosyl-(1->3)-O-lithocholate + H2O <=> D-glucose + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8944457", "l": "MAF1 translocates to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18393", "l": "(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine", "d": []}, {"i": "EC:2.6.1.40", "l": "\"(R)-3-amino-2-methylpropionate--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939201", "l": "ESR dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68689", "l": "3'-phosphoadenylyl sulfate + 3beta-androst-5-en-17-one 3-O-(beta-D-glucuronate) => 3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66583", "l": "3'-phosphoadenylyl sulfate + bisphenol A <=> adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76088", "l": "a dicarboxylate(in) + kynurenate(out) => a dicarboxylate(out) + kynurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53531", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134962", "l": "DHX36 binds DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65528", "l": "hexan-1-ol + octanoyl-CoA = CoA + hexyl octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090729", "l": "toxin activity", "d": ["Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655233", "l": "Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49255", "l": "D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-fructose 1-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120153", "l": "calcium-dependent carbohydrate binding", "d": ["Binding to a carbohydrate in the presence of calcium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71246", "l": "chloride(out) + hypotaurine(out) + 2 Na(+)(out) <=> chloride(in) + hypotaurine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964759", "l": "Alternative endo-mannosidase I route (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014456", "l": "GDIs block activation of RHOG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45765", "l": "H2O + L-aspartate 4-semialdehyde + NAD(+) => 2 H(+) + L-aspartate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74138", "l": "petunidin + UDP-alpha-D-galactose <=> petunidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15192", "l": "2 Fe(III)-[cytochrome c553] + formate <=> CO2 + 2 Fe(II)-[cytochrome c553] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015486", "l": "glycoside-pentoside-hexuronide:cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (glycoside, pentoside or hexuronide)(out) + monovalent cation(out) = (glycoside, pentoside or hexuronide)(in) + monovalent cation(in). The cation is Na+, Li+ or H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606288", "l": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693599", "l": "Association of Ku heterodimer with ends of DNA double-strand break (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70902", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033812", "l": "3-oxoadipyl-CoA thiolase activity", "d": ["Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14514", "l": "ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine => ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504188", "l": "FZD recruits DVL to the receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655347", "l": "Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985594", "l": "MYO9B inactivates RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27349", "l": "arsenate + mycothiol = arseno-mycothiol + H2O", "d": []}, {"i": "EC:2.8.4.2", "l": "\"arsenate-mycothiol transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67271", "l": "(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate <=> sch 210972", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675656", "l": "EDA:EDAR binds EDARADD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42403", "l": "lactose(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + lactose 6-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928639", "l": "p-EFNB binds GRB4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60392", "l": "Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O = Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052868", "l": "protein-lysine lysyltransferase activity", "d": ["Catalysis of the reaction: protein-lysine + protein-lysine = protein N6-(lysyl)-L-lysine + protein. This reaction is the addition of lysine group from one protein to a lysine residue in a second protein, producing N6-(lysyl)-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71303", "l": "RPE dimers isomerise RU5P to XY5P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034859", "l": "benzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: benzothiazole + 1/2 O2 = 2-hydroxybenzothiazole."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74531", "l": "AH2 + archaetidylglycerol + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaetidylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72721", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+) => (R)-N(6)-dihydrolipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018773", "l": "acetylpyruvate hydrolase activity", "d": ["Catalysis of the reaction: acetylpyruvate + H2O = acetate + H+ + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848758", "l": "PTK6 phosphorylates AKT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62479", "l": "3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] <=> 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42789", "l": "cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33345", "l": "2-iminoacetate + H2O2 => glycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156910", "l": "Formation of eEF1B complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42292", "l": "a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.274", "l": "\"phosphate acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106264", "l": "protein serine kinase activity (using GTP as donor)", "d": ["Catalysis of the reactions: GTP + L-seryl-[protein] = GDP + H+ + O-phospho-L-seryl-[protein]."]}, {"i": "RHEA:64020", "l": "GTP + L-seryl-[protein] = GDP + H(+) + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5649856", "l": "Oxidative damage to the AP site (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25682", "l": "L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008851", "l": "ethanolamine ammonia-lyase activity", "d": ["Catalysis of the reaction: ethanolamine = acetaldehyde + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72621", "l": "Ribosomal scanning  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24017", "l": "16-epivellosimine + acetyl-CoA => CoA + vinorine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852317", "l": "PLK1 phosphorylates GTSE1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102783", "l": "beta-carotene oxygenase activity", "d": ["Catalysis of the reaction: beta-carotene + 2 O2 = 2 beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56488", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19836", "l": "(6S)-10-formyltetrahydrofolate + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864698", "l": "KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-171122", "l": "LDL + LDLR => LDL:LDLR complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34568", "l": "CDP-alpha-D-paratose + NADP(+) => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10395", "l": "(E)-cinnamyl alcohol + NADP(+) <=> (E)-cinnamaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20123", "l": "AMP + diphosphate + L-glutaminyl-tRNA(Gln) => ATP + L-glutamine + tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362522", "l": "ALDHs oxidise atRAL to atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40596", "l": "dodecanedioyl-CoA + H2O => CoA + dodecanedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76084", "l": "(11R)-carlactone + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-19-hydroxycarlactone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14061", "l": "H2O + N-(carboxymethyl)-D-alanine + NAD(+) = glycine + H(+) + NADH + pyruvate", "d": []}, {"i": "EC:1.5.1.22", "l": "\"strombine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50270", "l": "(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004065", "l": "arylsulfatase activity", "d": ["Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71787", "l": "2-oxoadipate + O2 = (R)-2-hydroxyglutarate + CO2", "d": []}, {"i": "EC:1.13.11.93", "l": "\"2-oxoadipate dioxygenase/decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.288", "l": "\"2-O-sulfo trehalose long-chain-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734597", "l": "MEF2C binds the SMYD1 (BOP) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60827", "l": "H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate <=> 2 AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10800", "l": "diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine", "d": []}, {"i": "EC:2.4.2.22", "l": "\"xanthine phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71568", "l": "5-phosphomethyl-dUMP in DNA + L-serine => 5-O-(L-seryl)-dTMP in DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16572", "l": "2-oxoglutarate + L-lysyl-[collagen] + O2 <=> (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008098", "l": "5S rRNA primary transcript binding", "d": ["Binding to an unprocessed 5S ribosomal RNA transcript."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000253", "l": "3-keto sterol reductase activity", "d": ["Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009309", "l": "RUNX2 binds STUB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693478", "l": "HTR1A binds HTR1A agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.34", "l": "\"plasma kallikrein\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12283", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45930", "l": "4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA => 15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731924", "l": "EDNRA binds EDNs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102859", "l": "1-18:1-2-18:2-phosphatidylcholine desaturase activity (SN2-18:3 forming)", "d": ["Catalysis of the reaction: 1-18:1-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:1-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624112", "l": "CEBPA binds CDK4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9639286", "l": "RRAGC,D exchanges GTP for GDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10668", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)", "d": []}, {"i": "EC:2.3.2.3", "l": "\"lysyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46835", "l": "4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH <=> 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20472", "l": "H2O + IMP <=> D-ribose 5-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15389", "l": "ATP = 3',5'-cyclic AMP + diphosphate", "d": []}, {"i": "EC:4.6.1.1", "l": "\"adenylate cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111916", "l": "Dimerization of p-S119-CREB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632652", "l": "Hh-Npp binds CDON and PTCH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.32", "l": "\"endo-1,3-beta-xylanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17394", "l": "3-maleylpyruvate => 3-fumarylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75389", "l": "D-ribose 5-phosphate + queuine => H2O + queuosine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60916", "l": "a cytidine in mRNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848339", "l": "PNPLA5 hydrolyzes TAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56869", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA => (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75910", "l": "ADP-L-glycero-beta-D-manno-heptose + L-seryl-[protein] <=> ADP + H(+) + O-(L-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392834", "l": "Activation of EPACs by cAMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362437", "l": "C-terminal Hh fragments are bound by lectins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847977", "l": "FRK phosphorylates PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611277", "l": "P2RY12 binds P2RY12 antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20575", "l": "calcitriol + H2O + 2 oxidized [adrenodoxin] => calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-984671", "l": "Chromokinesins form dimers (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49963", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 <=> 5,10-dihydrophenazine + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17790", "l": "(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine => (S)-reticuline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28179", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate => colnelenate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66437", "l": "NADP(+) + pentan-3-one => H(+) + NADPH + pent-1-en-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60381", "l": "L-dehydroascorbate(out) => L-dehydroascorbate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000036", "l": "acyl carrier activity", "d": ["Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429992", "l": "PARN deadenylates mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70357", "l": "biuret + CO2 => 1-carboxybiuret + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380170", "l": "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624112", "l": "CEBPA binds CDK4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16329", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66052", "l": "indole-3-pyruvate + L-kynurenine = H2O + kynurenate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371422", "l": "ATP hydrolysis by HSP70 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162914", "l": "Myristoylation of Nef (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22397", "l": "1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 => glycolaldehyde + guaiacol + H2O + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40690", "l": "1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol <=> 1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098639", "l": "collagen binding involved in cell-matrix adhesion", "d": ["Any collagen binding that occurs as part of cell-matrix adhesion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69173", "l": "Joining of adjacent Okazaki fragments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174097", "l": "Association of Emi1 with Cdh1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38069", "l": "1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73821", "l": "choline(out) + 2 H(+)(in) => choline(in) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70318", "l": "beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036102", "l": "Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BMG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22444", "l": "(E)-coniferol + NADP(+) = (E)-coniferaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211960", "l": "CYP2U1 19-hydroxylates ARA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195304", "l": "Association of beta-catenin with the destruction complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090624", "l": "endoribonuclease activity, cleaving miRNA-paired mRNA", "d": ["Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an miRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264435", "l": "Dissociation of the COP1-p53 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25496", "l": "(2E)-geranyl diphosphate = (1S,5S)-beta-pinene + diphosphate", "d": []}, {"i": "EC:4.2.3.120", "l": "\"(-)-beta-pinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20790", "l": "ADP-alpha-D-ribose 1''-phosphate + H(+) + nicotinamide => NAD(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801762", "l": "REG3A oligomerize to form a pore complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26234", "l": "(2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57343", "l": "3-hydroxy-L-kynurenine + S-adenosyl-L-methionine <=> 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67771", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60390", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) => Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.863640214551324", "identifiers": [{"i": "GO:0099106", "l": "ion channel regulator activity", "d": ["Modulates the activity of a channel via direct interaction with it. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9727188", "l": "ATP4A:ATP4B binds PPIs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24581", "l": "D-sorbitol 6-phosphate + H2O => D-sorbitol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354060", "l": "Translocation of RIAM to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63877", "l": "2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2 => (4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45782", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56804", "l": "2 cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27608", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9615249", "l": "ARBs bind AGRT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44947", "l": "1-O-alkyl-3-acyl-sn-glycerol + H2O <=> 1-O-alkyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0140996", "l": "histone H3 kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39496", "l": "3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62850", "l": "GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65315", "l": "an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] <=> a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47483", "l": "deoxycholate + NADP(+) <=> 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0008486", "l": "diphosphoinositol-polyphosphate diphosphatase activity", "d": ["Catalysis of the reaction: diphospho-1D-myo-inositol polyphosphate + H2O = 1D-myo-inositol polyphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2203516", "l": "Alpha-1-Microglobulin is cleaved (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41814", "l": "butanoyl-[ACP] + NADP(+) => (2E)-butenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035923", "l": "flurbiprofen binding", "d": ["Binding to flurbiprofen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70059", "l": "a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42325", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-L-Glu)(n) => 3 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50006", "l": "11a-hydroxytetracycline + H2O + NADP(+) => H(+) + NADPH + O2 + tetracycline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805399", "l": "TAF1 phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52373", "l": "17beta-estradiol + 3'-phosphoadenylyl sulfate => 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57132", "l": "L-ascorbate + O2 + tyramine = (R)-octopamine + H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211191", "l": "Association of DFF with alpha:beta importin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35754", "l": "ATP + kanosamine <=> ADP + D-kanosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12945", "l": "2'-hydroxybiphenyl-2-sulfinate + H2O = biphenyl-2-ol + H(+) + sulfite", "d": []}, {"i": "EC:3.13.1.3", "l": "\"2'-hydroxybiphenyl-2-sulfinate desulfinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36812", "l": "acetyl-CoA + GDP-alpha-D-perosamine => CoA + GDP-N-acetyl-alpha-D-perosamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16172", "l": "ATP + L-glutamate + NH4(+) <=> ADP + H(+) + L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71086", "l": "estrone 3-sulfate(out) + 2 Na(+)(out) <=> estrone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955869", "l": "Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65083", "l": "asperaculane D + O2 + reduced [NADPH--hemoprotein reductase] <=> asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14888", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] <=> ADP-D-ribose + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322427", "l": "Beta-catenin recruits CBP/p300 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22293", "l": "benzoyl-CoA + 3 H(+) + 3 malonyl-CoA => biphenyl-3,5-diol + 4 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74711", "l": "Phosphorylation of IRS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58253", "l": "H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] => ADP-D-ribose + L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69554", "l": "(S)-serinol phosphate + 2-oxoglutarate => dihydroxyacetone phosphate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.192", "l": "\"23S rRNA (adenine(2503)-C(2))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22232", "l": "H(+) + NADPH + presqualene diphosphate = diphosphate + NADP(+) + squalene", "d": []}, {"i": "EC:1.3.1.96", "l": "\"Botryococcus squalene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811539", "l": "Reinforcement of the Cornified Envelope (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46964", "l": "lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate", "d": []}, {"i": "EC:1.1.1.436", "l": "\"lactate dehydrogenase (NAD(+),ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018655", "l": "2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA + NADH + H+ + O2 = NAD+ + H2O + delta2,5-3,4,4-trimethylpimelyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005025", "l": "transforming growth factor beta receptor activity, type I", "d": ["Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382053", "l": "Translocation of PDGF from ER to Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3965450", "l": "DAAM1 recruits PFN1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25516", "l": "an acyl-CoA + tropine = CoA + H(+) + O-acyltropine", "d": []}, {"i": "EC:2.3.1.185", "l": "\"tropine acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60169", "l": "a fatty acid + ATP => a fatty acyl monophosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49392", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549428", "l": "Expression of FACTOR VII (F7) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685011", "l": "ATR activation at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21209", "l": "H2O + O-phospho-L-serine => L-serine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-982765", "l": "Growth hormone forms dimers and oligomers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097682", "l": "intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity", "d": ["Enables the transmembrane transfer of cations by a channel that opens when phosphatidylinositol-3,5-bisphosphate has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690873", "l": "ACO1 binds 4Fe-4S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696807", "l": "N-glycan mannose trimming of Spike (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848124", "l": "PTK6 phosphorylates STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38041", "l": "a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299359", "l": "Activation of TALK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22437", "l": "(2E,6E)-farnesyl diphosphate + H2O => (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56191", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164840", "l": "ADP and Pi bind to ATPase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17480", "l": "precorrin-6B + 2 S-adenosyl-L-methionine <=> CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46657", "l": "androst-4-ene-3,17-dione + H(+) + NADPH => 5beta-androstane-3,17-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.10.3", "l": "\"bacterial tyrosine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33931", "l": "all-trans-zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal", "d": []}, {"i": "EC:1.13.11.65", "l": "\"carotenoid isomerooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22582", "l": "(2Z)-2-hydroxypenta-2,4-dienoate + H2O => (S)-4-hydroxy-2-oxopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19115", "l": "(8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+) => (8Z,11Z,14Z)-heptadecatrienal + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507871", "l": "Aquaporins passively transport glycerol out of cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132233", "l": "Proteolytic cleavage of complement factor C4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57902", "l": "adenosine in U6 snRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0001883", "l": "purine nucleoside binding", "d": ["Binding to a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28126", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose = alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}, {"i": "EC:2.7.8.31", "l": "\"undecaprenyl-phosphate glucose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73168", "l": "CoA(out) + NAD(+)(in) => CoA(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37330", "l": "ATP + H2O + L-methionyl-L-alanine(out) <=> ADP + H(+) + L-methionyl-L-alanine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374919", "l": "Noradrenaline clearance from the synaptic cleft (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.10", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097602", "l": "cullin family protein binding", "d": ["Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58246", "l": "ADP-D-ribose + L-lysyl-[protein] => H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222533", "l": "ERK1/2-activated AP1 complex binds KDM6B promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38981", "l": "1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55092", "l": "D-fructose + UDP-alpha-D-glucose = H(+) + sucrose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11992", "l": "L-pipecolate + O2 = H(+) + H2O2 + L-1-piperideine-6-carboxylate", "d": []}, {"i": "EC:1.5.3.7", "l": "\"L-pipecolate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050324", "l": "taurocyamine kinase activity", "d": ["Catalysis of the reaction: ATP + taurocyamine = N-phosphotaurocyamine + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55382", "l": "a 3-oxo bile acid CoA + H(+) + NADH => a 3alpha-hydroxy bile acid CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6805811", "l": "Release of SEPT4 from mitochondria (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006508", "l": "PVALB gene expression is repressed by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36223", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810724", "l": "PI3 binds the bacterial surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16962", "l": "epsilon-(gamma-L-glutamyl)-L-lysine => 5-oxo-L-proline + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39373", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+) => 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.4", "l": "\"uracil/thymine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390641", "l": "ADRA1A,B,D bind ADR,NAd (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52723", "l": "5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O <=> 5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0032555", "l": "purine ribonucleotide binding", "d": ["Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69230", "l": "an epithionitrile + sulfate => a (Z)-N-(sulfonatooxy)alkenimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51875", "l": "dimethylallyl diphosphate + umbelliferone <=> diphosphate + osthenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350901", "l": "Iodide is organified (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875183", "l": "CBL monoubiquitinates activated MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61083", "l": "(+)-minovincinine + acetyl-CoA <=> (+)-echitovenine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59445", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A => 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30093", "l": "a ubiquinol + NH4(+) + pyruvate => a ubiquinone + D-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42125", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) => androsterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47311", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28939", "l": "H(+)(in) + xanthosine(in) = H(+)(out) + xanthosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928625", "l": "PAKs autophosphorylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45072", "l": "(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] = (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28994", "l": "N-acetylneuraminate(in) <=> N-acetylneuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14432", "l": "a [oligopeptide](in) + ATP + H2O <=> a [oligopeptide](out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20591", "l": "(2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein] => glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10567", "l": "H2O + oxaloacetate 4-methyl ester <=> H(+) + methanol + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31462", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate <=> 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614271", "l": "Autocleavage of ADGRG6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43831", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51511", "l": "2-oxoglutarate + L-proline + O2 <=> CO2 + succinate + trans-4-hydroxy-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750226", "l": "NLRC5 binds IKBKB and CHUK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709179", "l": "DPP4 binds DPP4 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008196", "l": "vitellogenin receptor activity", "d": ["Receiving vitellogenin, and delivering vitellogenin into the cell via endocytosis."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034529", "l": "2-hydroxy-3-carboxy-benzalpyruvate hydratase-aldolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-3-carboxybenzalpyruvate + H2O = 3-formylsalicylic acid + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0051903", "l": "S-(hydroxymethyl)glutathione dehydrogenase activity", "d": ["Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140947", "l": "histone H3K9me2 methyltransferase activity", "d": ["Catalysis of the reaction: N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the dimethylated lysine residue at position 9 of histone H3, producing histone H3K9me3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70094", "l": "ethanol + o-quinone methide <=> hydroxyclavatol ethyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2681694", "l": "TNC binds Syndecan-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800798", "l": "The PIDDosome binds CASP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664867", "l": "NBR1 binds MAP1LC3B (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56100", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) = [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}, {"i": "EC:2.7.7.100", "l": "\"SAMP-activating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21036", "l": "2 acetyl-CoA = acetoacetyl-CoA + CoA", "d": []}, {"i": "EC:2.3.1.9", "l": "\"acetyl-CoA C-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68970", "l": "H2O2 + phenylglyoxylate => mandelate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110244", "l": "Excision of FapyG by OGG1 glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38357", "l": "(E)-cinnamoyl-CoA + H2O => (R)-3-phenyllactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30700", "l": "2-oxoglutarate + beta-alanine => 3-oxopropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19587", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADH => lithocholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692934", "l": "BACE1 binds GGA1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43398", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632653", "l": "Hh-Npp binds BOC:PTCH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030281", "l": "structural constituent of cutaneous appendage", "d": ["The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16624", "l": "dihydrosanguinarine + H(+) + O2 <=> H2O2 + sanguinarine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654533", "l": "KRAS4B recycles to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854981", "l": "SHC1 in the RET complex is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36676", "l": "octacosanoyl-CoA + sphinganine => CoA + H(+) + N-(octacosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36396", "l": "7-dehydrocholesterol + NADP(+) => 7-dehydrodesmosterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34113", "l": "H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine => carboxyspermidine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210444", "l": "L-Glutamate loading of synaptic vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373075", "l": "Metabotropic glutamate receptors bind glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42529", "l": "uridine(955/2504/2580) in 23S rRNA => pseudouridine(955/2504/2580) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31511", "l": "chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50294", "l": "all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin] => all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912467", "l": "BRCA1 is recruited to unsynapsed regions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33195", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050550", "l": "pinene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = pinene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029158", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64189", "l": "an N-(fatty acyl)-L-tyrosine + H2O => a fatty acid + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5220959", "l": "TDG excises 5-formylcytosine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41894", "l": "(2E)-tetradecenoyl-[ACP] + H2O => (3R)-hydroxytetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63835", "l": "(6E)-8-methylnon-6-enoyl-CoA + vanillylamine <=> capsaicin + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5251942", "l": "Hikeshi binds HSP70s:ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29494", "l": "(2E,6E)-farnesyl diphosphate <=> cis-muurola-4(14),5-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19638", "l": "D-nopaline + H2O + NADP(+) => 2-oxoglutarate + H(+) + L-arginine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11724", "l": "[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite = 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol", "d": []}, {"i": "EC:1.8.4.8", "l": "\"phosphoadenylyl-sulfate reductase (thioredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396399", "l": "Fibrillins bind BMPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340214", "l": "CYGB binds O2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69034", "l": "(2S)-2-nitrosobutanedioate + H2O => N,N-dihydroxy-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29499", "l": "(2E,6E)-farnesyl diphosphate = (+)-alpha-barbatene + diphosphate", "d": []}, {"i": "EC:4.2.3.69", "l": "\"(+)-alpha-barbatene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047581", "l": "4-methyleneglutamate-ammonia ligase activity", "d": ["Catalysis of the reaction: 4-methylene-L-glutamate + ATP + NH4 = 4-methylene-L-glutamine + AMP + diphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617855", "l": "HOXC4 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22525", "l": "2 A + a carotenoid beta-end derivative => a carotenoid phi-end derivative + 2 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12083", "l": "acetyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxobutanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11334", "l": "diphosphate + RNA(n)-3'-adenine ribonucleotide => ATP + RNA(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61312", "l": "germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34270", "l": "acetyl-CoA + fumigaclavine B <=> CoA + fumigaclavine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70547", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684836", "l": "CLEC1B dimer binds PDPN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44123", "l": "hexadecanoyl-CoA + octadecan-1-ol <=> CoA + octadecanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31736", "l": "3-oxocholan-24-oyl-CoA + NAD(+) => 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0000339", "l": "RNA cap binding", "d": ["Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36156", "l": "AH2 + Co(II)-factor III + S-adenosyl-L-methionine => A + Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686930", "l": "RIPK3 is cleaved by CASP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54869", "l": "(2E)-butenoyl-[ACP] + H(+) + NADH => butanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30404", "l": "Fe(3+)(out) + L-ascorbate(in) => Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047502", "l": "(+)-sabinol dehydrogenase activity", "d": ["Catalysis of the reaction: (+)-cis-sabinol + NAD+ = (1S,5S)-sabinone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67330", "l": "trichosetin => (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388830", "l": "PI3K binds ICOS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627107", "l": "XIAP binds CASP7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21759", "l": "deacetylisoipecoside + H2O <=> dopamine + secologanin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44060", "l": "2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA = 2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031796", "l": "type 1 metabotropic GABA receptor binding", "d": ["Binding to a type 1 metabotropic GABA receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69814", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55040", "l": "(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.179", "l": "\"beta-ketoacyl-[acyl-carrier-protein] synthase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956659", "l": "ABL1 phosphorylates YAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964475", "l": "DREAM complex binds the TOP2A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168136", "l": "NOTCH3 binds DLL4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50222", "l": "(R)-demethyl-4-deoxygadusol => (S)-demethyl-4-deoxygadusol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39612", "l": "3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39722", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate <=> 24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55754", "l": "coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798743", "l": "Exocytosis of secretory granule membrane proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9649733", "l": "mature p21 RAS binds GDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45732", "l": "D-ribulose 5-phosphate + L-tyrosine = (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": []}, {"i": "EC:4.1.99.24", "l": "\"L-tyrosine isonitrile synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52391", "l": "ATP + D-threonate <=> 4-O-phospho-D-threonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655443", "l": "PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60076", "l": "4beta-hydroxymethyl-4alpha-methylzymosterol + H(+) + NADH + O2 = 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964912", "l": "DHAP from Ery4P and PEP (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-179421", "l": "Degradation of multiubiquitinated Nek2A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904713", "l": "beta-catenin destruction complex binding", "d": ["Binding to a beta-catenin destruction complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69645", "l": "(2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56899", "l": "a carboxylate + ATP + H(+) <=> an acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008869", "l": "galactonate dehydratase activity", "d": ["Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41266", "l": "NAD(+) + prostaglandin A1 <=> 15-oxo-prostaglandin A1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39424", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA => (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43750", "l": "AMP + diphosphate + hexacosanoyl-CoA => ATP + CoA + hexacosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55803", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-acyleicosasphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213195", "l": "Formation of anchoring fibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202248", "l": "Phosphorylation of PLC-gamma1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41322", "l": "(9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+) => 1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35188", "l": "(Z)-3-aminoperacrylic acid + AH2 => (Z)-3-aminoacrylate + A + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26084", "l": "(2E,6E)-farnesyl diphosphate <=> (Z)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687465", "l": "MRN complex binds RBBP8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30526", "l": "GTP + L-glutamate + oxidized coenzyme F420-1 <=> GDP + H(+) + oxidized coenzyme F420-2 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191402", "l": "Reduction of presqualene diphosphate to form squalene (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0003843", "l": "1,3-beta-D-glucan synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005352", "l": "alpha-glucoside:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72455", "l": "fumarate(out) + 3 H(+)(out) = fumarate(in) + 3 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58594", "l": "1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75232", "l": "H2O + L-galactono-1,4-lactone => H(+) + L-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474210", "l": "Collagen type III degradation by MMP14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214395", "l": "Monomeric PGN bound PGRP-LE oligomerises in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.3", "l": "\"P-type Na(+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65876", "l": "5alpha-androst-1-ene-3,17-dione + H2O = 1-hydroxy-5alpha-androstan-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34466", "l": "8-hydroxycopalyl diphosphate <=> cis-abienol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24037", "l": "a ribonucleoside 5'-phosphate + ATP => a ribonucleoside 5'-diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295613", "l": "SPRY2 binds GRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.4", "l": "\"poly(A)-specific ribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202129", "l": "HSP90 binds eNOS:Caveolin-1:CaM complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013361", "l": "NEXT3 is cleaved to produce NICD3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874080", "l": "SRC phosphorylates PTK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39928", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70473", "l": "a 2'-deoxycytidine in single-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in single-stranded DNA + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74706", "l": "(3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 5-dehydro-6-demethoxyfumagillol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38065", "l": "1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59800", "l": "decanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3076881", "l": "BCTN translocates to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65092", "l": "asperaculane G + O2 + reduced [NADPH--hemoprotein reductase] = aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202233", "l": "Inactivation of Lck by Csk (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70943", "l": "L-isoleucine(in) = L-isoleucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.20", "l": "\"carboxypeptidase U\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74694", "l": "2 a 2,3-di-O-phytanyl-sn-glycerophospholipid + 2 AH2 + 4 S-adenosyl-L-methionine <=> 4 5'-deoxyadenosine + 2 A + a glycerol dibiphytanyl glycerol tetraether phospholipid + 4 H(+) + 4 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70042", "l": "3-dehydro-6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 3-dehydroteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009378", "l": "Estrogen-responsive CCND1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18617", "l": "ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate", "d": []}, {"i": "EC:4.1.1.49", "l": "\"phosphoenolpyruvate carboxykinase (ATP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687097", "l": "p-S857 NCOA3 binds ETV4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34627", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15017", "l": "a phosphate monoester + H2O = an alcohol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52412", "l": "4-phospho-D-erythronate + NAD(+) = 3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36466", "l": "glycyl-L-glutamate + H2O <=> glycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18121", "l": "an S-substituted L-cysteine + H2O = a thiol + NH4(+) + pyruvate", "d": []}, {"i": "EC:4.4.1.13", "l": "\"cysteine-S-conjugate beta-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58197", "l": "H2O + N(6)-acetyl-L-lysyl-[histone] => acetate + L-lysyl-[histone]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730841", "l": "Phosphorylation and activation of VAV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9010872", "l": "SLIT2 binds Dystroglycan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70222", "l": "corticosterone + H(+) + NADPH <=> 20beta-dihydrocorticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16870", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855232", "l": "RELN:VLDLR binds DAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65781", "l": "2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26529", "l": "a (3R)-3-hydroxyacyl-CoA <=> a (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019154", "l": "glycolate dehydrogenase activity", "d": ["Catalysis of the reaction: A + glycolate = AH(2) + glyoxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928646", "l": "EPHAs bind EFNAs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70241", "l": "PCK1 phosphorylates OA to yield PEP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0042171", "l": "lysophosphatidic acid acyltransferase activity", "d": ["Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18935", "l": "(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63897", "l": "aspulvinone E + hnu => isoaspulvinone E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76090", "l": "a dicarboxylate(in) + kynurenate(out) <=> a dicarboxylate(out) + kynurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448702", "l": "Caspase-1 active tetramer formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73369", "l": "D-xylose(in) + 2 Na(+)(in) => D-xylose(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61551", "l": "ent-kaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ent-7alpha-hydroxykaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12297", "l": "deacetylipecoside + H2O => dopamine + secologanin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033188", "l": "sphingomyelin synthase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49217", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17124", "l": "carbamoyl phosphate + L-lysine <=> H(+) + L-homocitrulline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602353", "l": "Defective IRAK4 variants do not bind MyD88:MAL:BTK:activated TLR2/4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59202", "l": "diphosphate + docosanoyl-AMP => ATP + docosanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607746", "l": "PKC-delta is activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20547", "l": "3-hydroxy-L-kynurenine + H2O + NADP(+) => H(+) + L-kynurenine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63129", "l": "H2O + N-docosanoyl-ethanolamine => docosanoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2294574", "l": "Condensin II-mediated condensation of prophase chromosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014812", "l": "ROBOs bind keratan sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209921", "l": "Monoiodinated tyrosine can be deiodinated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019237", "l": "centromeric DNA binding", "d": ["Binding to a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72942", "l": "2 Na(+)(out) + propanoate(out) <=> 2 Na(+)(in) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53181", "l": "D-erythrose => D-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18744", "l": "10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA <=> 10-deacetylbaccatin III + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679239", "l": "ULK complex translocates to the ER (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983700", "l": "SYK binds the activated BCR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.41", "l": "\"riboflavin reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877396", "l": "IL2RA (CD25) gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093332", "l": "p-EPHB phosphorylates SDC2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57297", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O => a 2'-deoxyguanosine in DNA + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.75", "l": "\"very-long-chain acyl-lipid omega-9 desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332363", "l": "Autophosphorylation and activation of CAMK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40794", "l": "H2O + hexacosanoyl-CoA <=> CoA + H(+) + hexacosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824216", "l": "MSGN1 binds the NOTCH1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015168", "l": "glycerol transmembrane transporter activity", "d": ["Enables the transfer of glycerol from one side of a membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167014", "l": "pro-beta-NGF homodimer transits to the golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-481007", "l": "Exocytosis of platelet alpha granule contents (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40413", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-996727", "l": "REST recruits the BHC complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42019", "l": "cortisone + NAD(+) <=> 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50611", "l": "leukotriene B4 + NADP(+) <=> 12-oxo-leukotriene B4 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57403", "l": "3-O-acetylpapaveroxine + H2O <=> acetate + H(+) + narcotine hemiacetal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111264", "l": "Addition of nucleotides between position +11 and +30 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202731", "l": "JAM3 dimerises (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864718", "l": "TFAP2A,TFAP2C homodimers:CITED2 binds PITX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866941", "l": "MID1IP1 binds THRSP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24033", "l": "sucrose => 6-O-alpha-D-glucopyranosyl-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63608", "l": "apelin-17 + H2O = apelin-16 + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25782", "l": "3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate => H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34729", "l": "15-methylhexadecasphinganine + a carboxylate => H2O + N-acyl-15-methylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029680", "l": "Caspase-7 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55633", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35155", "l": "(S)-4,5-dihydroxypentane-2,3-dione = (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17619", "l": "glutathione + leukotriene A4 => leukotriene C4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23616", "l": "1,2-dihydro-alpha-santonin + NADP(+) = alpha-santonin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3245898", "l": "TCN1 binds correnoids in the circulation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58774", "l": "1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64858", "l": "diphosphate + phomopsene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985594", "l": "MYO9B inactivates RHOA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34465", "l": "cis-abienol + diphosphate => 8-hydroxycopalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426151", "l": "SREBP1A,2 binds the SQLE promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32686", "l": "5-hydroxymethylfurfural + 2 H2O + 3 O2 <=> 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74789", "l": "L-histidyl-L-proline diketopiperazine(out) => L-histidyl-L-proline diketopiperazine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29304", "l": "2 H(+)(in) + succinate(in) => 2 H(+)(out) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43966", "l": "1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28981", "l": "H(+)(in) + nitrite(out) => H(+)(out) + nitrite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73841", "l": "AMP + 2 H(+) + phenyl phosphate + phosphate => ATP + H2O + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170846", "l": "TGFBR2 recruits TGFBR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38050", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61576", "l": "(4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+) = (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877620", "l": "ECE2 cleaves EDN1(53-90) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26010", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71672", "l": "glycyl-L-glutamine(out) + H(+)(out) => glycyl-L-glutamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805285", "l": "PLK3 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190829", "l": "Lysosomal degradation of gap junction plaques (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30835", "l": "H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40080", "l": "docosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67477", "l": "dimethylallyl diphosphate + L-glutamate => diphosphate + prekainate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909732", "l": "Phosphorylation of STAT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56734", "l": "echinenone + H2O => 4,4-dihydroxy-all-trans-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72221", "l": "3 hydrogencarbonate(in) + Na(+)(in) => 3 hydrogencarbonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937419", "l": "CBR3 reduces DOX to DOXOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21773", "l": "cytidine(6666) in apoB mRNA + H(+) + H2O => NH4(+) + uridine(6666) in apoB mRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27938", "l": "(3R)-3-hydroxy-D-aspartate = glycine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31521", "l": "3-methyl-2-butenal + 4'-apo-beta-carotenal => O2 + torulene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904768", "l": "all-trans-retinol binding", "d": ["Binding to all-trans-retinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390438", "l": "FAR2 reduces PalmCoA to HXOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22789", "l": "dimethylsulfonioacetate + L-homocysteine => (methylsulfanyl)acetate + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63443", "l": "(2R)-3-phosphoglycerate + GTP + H(+) <=> 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11548", "l": "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": []}, {"i": "EC:3.1.1.54", "l": "\"acetoxybutynylbithiophene deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61686", "l": "glycerol + H(+) + phosphocholine => glycero-2-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48482", "l": "1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40619", "l": "H2O + tridodecanoylglycerol = 2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68540", "l": "(2Z,6Z)-farnesyl diphosphate = (-)-alpha-cedrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69558", "l": "D-glucose(in) + H(+)(in) => D-glucose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47886", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22702", "l": "gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848110", "l": "SOCS3 binds activated PTK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33930", "l": "4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 <=> 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61606", "l": "[DsbA protein]-disulfide + [DsbB protein]-dithiol => [DsbA protein]-dithiol + [DsbB protein]-disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34458", "l": "all-trans-beta-carotene <=> 9-cis-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29402", "l": "H2O + ITP <=> diphosphate + H(+) + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25560", "l": "9alpha-copalyl diphosphate = 9beta-pimara-7,15-diene + diphosphate", "d": []}, {"i": "EC:4.2.3.35", "l": "\"syn-pimara-7,15-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50386", "l": "5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n) => H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47407", "l": "(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) <=> 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55808", "l": "a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73648", "l": "CTP(out) + IMP(in) => CTP(in) + IMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672948", "l": "MARK3 phosphorylates KSR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50334", "l": "1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74715", "l": "Autophosphorylation of insulin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53648", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether A + diphosphate", "d": []}, {"i": "EC:4.2.3.171", "l": "\"(+)-corvol ether A synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62112", "l": "(3S)-3-hydroxy-D-aspartate = H2O + iminosuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10009", "l": "[protein]-dithiol + a hydroperoxide => [protein]-disulfide + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "50.526619159739155", "identifiers": [{"i": "GO:0042277", "l": "peptide binding", "d": ["Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9718020", "l": "PTGFR binds PTGFR agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159868", "l": "Furin cleaves pro-factor VII to factor VII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49603", "l": "ATP + CoA + octanedioate <=> AMP + diphosphate + octanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2172678", "l": "PHF8 demethylates histone H4K20me1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60383", "l": "L-dehydroascorbate(out) <=> L-dehydroascorbate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35433", "l": "cyanidin 3,7-di-O-beta-D-glucoside + vanillate => 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34658", "l": "C30 botryococcene + 2 S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172194", "l": "Recruitment of PLK1 to phosphorylated GORASP1 (GRASP65) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202328", "l": "Translocation of PKC theta to plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209924", "l": "Dopa is decarboxylated to dopamine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47701", "l": "H(+) + ketocytochalasin + NADPH + O2 => H2O + iso-precytochalasin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373741", "l": "SDK2 homophillic interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53356", "l": "5,6-dihydrouridine(20b) in tRNA + NADP(+) = H(+) + NADPH + uridine(20b) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26048", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983144", "l": "Transport of Antigen peptide in to ER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5603467", "l": "Activated protein C is released from PROCR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47895", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018500", "l": "trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity", "d": ["Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + NAD+ = NADH + H+ + 9,10-dihydroxyphenanthrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31516", "l": "4'-apo-beta-carotenal + H2O + NAD(+) => 2 H(+) + NADH + neurosporaxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62401", "l": "(1R,2S)-ephedrine + NAD(+) => (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75865", "l": "all-trans-4-hydroxy-13,14-dihydroretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047998", "l": "hyoscyamine (6S)-dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-hyoscyamine + O2 = (6S)-6-hydroxyhyoscyamine + CO2 + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371518", "l": "SIRT1 binds to HSF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694428", "l": "LMAN family proteins bind glycosylated cargo (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611852", "l": "ADRB3 bind ADR,NAd (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69566", "l": "12 AMP + bacitracin A + 12 diphosphate + 12 H(+) + H2O => 12 ATP + L-asparagine + L-aspartate + L-cysteine + L-glutamate + L-histidine + 3 L-isoleucine + L-leucine + L-lysine + L-ornithine + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61460", "l": "a cytidine in RNA + S-adenosyl-L-methionine = a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-744886", "l": "The Ligand:GPCR:Gs complex dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34299", "l": "2'-deamino-2'-hydroxyneamine + 2-oxoglutarate = 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate", "d": []}, {"i": "EC:2.6.1.94", "l": "\"2'-deamino-2'-hydroxyneamine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39041", "l": "a dicarboxylate + 2 H(+) + NADH => an omega-oxo fatty acid + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11117", "l": "acetyl-CoA + an alkane-alpha,omega-diamine => an N-acetylalkane-alpha,omega-diamine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32445", "l": "all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694442", "l": "CNIH2,3 bind GRIA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16023", "l": "enol-oxaloacetate => oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45860", "l": "12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389463", "l": "Proteinase-activated receptors can bind thrombin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19078", "l": "H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] => 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36640", "l": "3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine => 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656207", "l": "CR2 RAF1 mutants don't bind YWHAB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45254", "l": "tetradecanoate(in) => tetradecanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141341", "l": "SMOX-3 oxidises SPN to SPM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28217", "l": "[thioredoxin]-dithiol + prostaglandin H2 <=> [thioredoxin]-disulfide + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68223", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol <=> (7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73100", "l": "3'-dephospho-CoA(in) + AMP(out) => 3'-dephospho-CoA(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57790", "l": "4-nitrocatechol + H(+) + NAD(+) + nitrite => 1,3-dinitrobenzene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12749", "l": "3,4,5-trihydroxybenzoate + H(+) = 1,2,3-trihydroxybenzene + CO2", "d": []}, {"i": "EC:4.1.1.59", "l": "\"gallate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47738", "l": "5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30009", "l": "ADP + H(+) + L-arabinose(in) + phosphate => ATP + H2O + L-arabinose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199404", "l": "CD40L binds CD40 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404134", "l": "RBP4:atROL binds TTR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445077", "l": "Transport of L1 from C-domain to P-domain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202127", "l": "eNOS synthesizes NO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61234", "l": "(S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-isoleucine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.2", "l": "\"lysosomal Pro-Xaa carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55270", "l": "(R)-glycerate + alpha-D-glucose 1-phosphate => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691150", "l": "TFR2 dimer binds 2xholoTF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811479", "l": "ING2 recruits EP300 to TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785762", "l": "IL13RA1 binds TYK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879942", "l": "The receptor is activated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-168412", "l": "MDP elicits a NOD2 response (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10068", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose = 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}, {"i": "EC:2.4.1.53", "l": "\"poly(ribitol-phosphate) beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712183", "l": "ADCY3:GNAL:GTP converts ATP to cAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28948", "l": "H(+)(out) + L-arabinose(in) => H(+)(in) + L-arabinose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38008", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine => 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16144", "l": "2'-deoxymugineate + NAD(+) <=> 3''-deamino-3''-oxonicotianamine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61410", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine => ATP + N(6)-(D-erythrulosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46579", "l": "H(+) + NADPH + O2 + sitosterol <=> 2 H2O + NADP(+) + stigmasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112510", "l": "IL6ST is tyrosine phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76065", "l": "3'-phosphoadenylyl sulfate(out) + adenosine 3',5'-bisphosphate(in) => 3'-phosphoadenylyl sulfate(in) + adenosine 3',5'-bisphosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0003847", "l": "1-alkyl-2-acetylglycerophosphocholine esterase activity", "d": ["Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158860", "l": "SULT1A1 dimer sulfonates NHABP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25229", "l": "L-arabinitol + NADP(+) = H(+) + L-arabinose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2172666", "l": "RB1 binds condensin II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-825631", "l": "Glucagon:GCGR mediates GTP-GDP exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47578", "l": "CMP + ganglioside GD1c (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67183", "l": "ATP + glycine + L-glutamyl-[protein] <=> ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3076905", "l": "Extracellular BTD hydrolyses BCTN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047550", "l": "2-oxoadipate reductase activity", "d": ["Catalysis of the reaction: 2-hydroxyadipate + NAD+ = 2-oxoadipate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55333", "l": "a 3'-hydroxyflavone + S-adenosyl-L-methionine => a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46066", "l": "(6Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43024", "l": "an S-substituted L-cysteine = 2-aminoprop-2-enoate + a thiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202709", "l": "JAM2 dimerises (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67599", "l": "heptadecasphing-4-enine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9634861", "l": "NPAS4 binds ARNT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875591", "l": "DOCK7 activates RAC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28022", "l": "ATP + holo-[ACP] + octanoate = AMP + diphosphate + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52775", "l": "7,8-dihydroneopterin 3'-triphosphate <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44135", "l": "2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734713", "l": "ORC6 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29292", "l": "(25S)-3-oxocholest-4-en-26-oate + ATP + CoA => (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68805", "l": "H2O + kojibiose => alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623588", "l": "Defective SLC12A1 does not cotransport Na+, K+, 2Cl- from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12725", "l": "D-iditol + NAD(+) = H(+) + keto-D-sorbose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802934", "l": "p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730903", "l": "Oligomerization of TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700168", "l": "Active ALK phosphorylates IRS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59990", "l": "cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH => cyclohexane-1-carbonyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41375", "l": "1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69074", "l": "Formation of Processive Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10677", "l": "(2R,3S)-3-isopropylmalate => 2-isopropylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805981", "l": "HMGB1 release from cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37867", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18266", "l": "6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) => 6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008697", "l": "4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity", "d": ["Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050035", "l": "L-sorbose oxidase activity", "d": ["Catalysis of the reaction: L-sorbose + O2 = 5-dehydro-D-fructose + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848077", "l": "PTK6 phosphorylates STAP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45563", "l": "L-isoleucine <=> D-allo-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74186", "l": "S-adenosyl-L-methionine + taxifolin <=> H(+) + S-adenosyl-L-homocysteine + taxifolin 4'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654651", "l": "Activated FGFR4 binds FRS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390649", "l": "CHRM1,3,5 bind acetylcholine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27975", "l": "6-carboxy-5,6,7,8-tetrahydropterin + H(+) => 7-carboxy-7-deazaguanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042043", "l": "neurexin family protein binding", "d": ["Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450088", "l": "GLUT1 tetramer binds 4xATP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090471", "l": "9,15,9'-tri-cis-zeta-carotene isomerase activity", "d": ["Catalysis of the reaction: 9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23194", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60831", "l": "a 5'-end triphospho-adenosine in mRNA + H2O <=> a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37058", "l": "3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate <=> 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15336", "l": "(S)-ureidoglycolate + NADP(+) <=> H(+) + N-carbamoyl-2-oxoglycine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106320", "l": "(R)-limonene 1,2-monooxygenase NADPH activity", "d": ["Catalysis of the reaction: (4R)-limonene + NADPH + H+ + O2 = NADP+ + H2O + (4R)-limonene-1,2-epoxide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008269", "l": "JAK pathway signal transduction adaptor activity", "d": ["The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2317314", "l": "AKT binds PDPK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36112", "l": "gibberellin A1 + S-adenosyl-L-methionine => O-methyl gibberellin A1 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20177", "l": "pyridoxine + UDP-alpha-D-glucose = 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.160", "l": "\"pyridoxine 5'-O-beta-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51038", "l": "2 H2O + indole-3-pyruvate imine dimer => 2 2-iminio-3-(indol-3-yl)propanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10417", "l": "fumarate + toluene => 2-benzylsuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64185", "l": "H2O + N-(9Z-octadecenoyl)-L-tyrosine => (9Z)-octadecenoate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701488", "l": "Active ALK phosphorylates JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25707", "l": "H(+) + N,N-dihydroxy-L-dihomomethionine => (E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73247", "l": "ladanein + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50479", "l": "anthraniloyl-CoA + L-cysteinyl-[PqsD protein] <=> CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16321", "l": "(S)-indan-1-ol + NADP(+) = H(+) + indan-1-one + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972975", "l": "POU5F1 (OCT4), SOX2, NANOG Bind the SALL1 Promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74745", "l": "3-O-methylkaempferol + H(+) + S-adenosyl-L-homocysteine => kaempferol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47954", "l": "[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+) => [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000074", "l": "TCN2 binds RCbl in the circulation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174124", "l": "Dephosphorylation of phospho-Cdh1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404135", "l": "RBP4 binds atROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106105", "l": "Ala-tRNA(Thr) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated ala-tRNA(thr)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50027", "l": "dodecanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.5.-", "l": "\"Methylenetransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177946", "l": "Pro-EGF is cleaved to form mature EGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016290", "l": "palmitoyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11423", "l": "NADPH + O2 + senecionine <=> H2O + NADP(+) + senecionine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60852", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018862", "l": "phenylphosphate carboxylase activity", "d": ["Catalysis of the reaction: phenylphosphate + CO2 + H2O = H+ + phosphate + 4-hydroxybenzoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36118", "l": "gibberellin A3 + S-adenosyl-L-methionine <=> O-methyl gibberellin A3 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37588", "l": "2-oxoglutarate + D-lysine => 6-amino-2-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25353", "l": "H(+) + L-cysteine + tRNA(Pro) => H2O + L-cysteinyl-tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24789", "l": "(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.248", "l": "\"cycloisomaltooligosaccharide glucanotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0015464", "l": "acetylcholine receptor activity", "d": ["Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41078", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466749", "l": "ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851866", "l": "MET binds RANBP10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986939", "l": "MECP2 binds the NCoR/SMRT complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042056", "l": "chemoattractant activity", "d": ["Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050504", "l": "mannosyl-3-phosphoglycerate synthase activity", "d": ["Catalysis of the reaction: 3-phospho-D-glycerate + GDP-alpha-D-mannose = 2-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62182", "l": "diphosphate + viteagnusin D => H2O + peregrinol diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10440", "l": "D-glucono-1,5-lactone + H2O = D-gluconate + H(+)", "d": []}, {"i": "EC:3.1.1.17", "l": "\"gluconolactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0016453", "l": "C-acetyltransferase activity", "d": ["Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53300", "l": "D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O = H(+) + N-carbamoyl-D-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44734", "l": "(9Z,12Z)-octadecadienoate + glycerol + H(+) => 2-(9Z,12Z-octadecadienoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982617", "l": "CYGB:O2 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654569", "l": "Activated FGFR1 binds FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39519", "l": "3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871373", "l": "BMX phosphorylates RUFY1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72396", "l": "2 chloride(out) + K(+)(out) + Na(+)(out) => 2 chloride(in) + K(+)(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13340", "l": "D-glucurono-6,2-lactone + H2O <=> D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72180", "l": "Cleavage of mRNA at the 3'-end (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24467", "l": "2-dehydro-3-deoxy-6-phospho-D-galactonate <=> D-glyceraldehyde 3-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29941", "l": "H(+)(out) + phosphate(out) => H(+)(in) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013158", "l": "CDC42 GDIs block activation of CDC42 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-179410", "l": "Association of Nek2A with MCC:APC/C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14215", "l": "ADP + beta-D-fructose 1,6-bisphosphate + H(+) => ATP + beta-D-fructose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36149", "l": "benzyl acetate + CoA => acetyl-CoA + benzyl alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0035662", "l": "Toll-like receptor 4 binding", "d": ["Binding to a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59747", "l": "(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68777", "l": "(2Z,6Z)-farnesyl diphosphate => diphosphate + germacrene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60684", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) = (11R)-dihydroartemisinate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13755", "l": "2-oxoglutarate + H(+) + L-glutamine + NADH => 2 L-glutamate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69053", "l": "RFC binding displaces Pol Alpha (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607747", "l": "TRAF6 binds MALT1 oligomers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69185", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-glycerol 1-phosphate => diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20825", "l": "adenosine + ATP => ADP + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693540", "l": "MRN activates ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31543", "l": "all-trans-zeaxanthin + 2 UDP-alpha-D-glucose = 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)", "d": []}, {"i": "EC:2.4.1.276", "l": "\"zeaxanthin glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.40", "l": "\"hex-5-enoyl-[acyl-carrier protein] acetylenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051994", "l": "P-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the phosphorus atom of an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3215295", "l": "USP7 deubiquitinates MDM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2299620", "l": "Collagen XI cross-links with collagen II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016521", "l": "pituitary adenylate cyclase activating polypeptide activity", "d": ["The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870461", "l": "RABGGTA and RABGGTB bind (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508451", "l": "PTK2B is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659380", "l": "Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953339", "l": "DNPH1 hydrolyses dGMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45859", "l": "3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948136", "l": "ULK1 Translocates to the mitochondria (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58493", "l": "ATP + Fe(III)-enterobactin(out) + H2O => ADP + Fe(III)-enterobactin(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75670", "l": "(11Z,14Z,17Z)-eicosatrienoate + O2 <=> 12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8953037", "l": "E2F8 forms homodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36159", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin] = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097098", "l": "DNA/RNA hybrid annealing activity", "d": ["An activity that facilitates the base-pairing of single-stranded RNA to double-stranded DNA resulting in the formation of R-loops."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73743", "l": "2 H(+)(out) + serotonin(in) = 2 H(+)(in) + serotonin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54387", "l": "a 3-oxo-5alpha-steroid + NADP(+) <=> a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250280", "l": "ROS oxidize thioredoxin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56183", "l": "8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate <=> 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67929", "l": "a 3'-end 2',3'-cyclophospho-uridine-RNA + H2O => a 3'-end 3'-phosphouridine-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46338", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA => 3-oxochola-4,17-dien-22-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798044", "l": "BTG2 binds CCR4-NOT complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443418", "l": "GP1b signaling involves c-Src (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61916", "l": "ATP + fluconazole(in) + H2O = ADP + fluconazole(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975100", "l": "Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391934", "l": "DP2 receptor can bind PGD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.84", "l": "\"alcohol-forming fatty acyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31103", "l": "7,8-dihydrofolate + NADP(+) = folate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27488", "l": "allantoate + 2 H(+) + H2O <=> (S)-2-ureidoglycine + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59162", "l": "AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] => ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66837", "l": "4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase] => asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9759158", "l": "SQSTM1 oligomerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019531", "l": "oxalate transmembrane transporter activity", "d": ["Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001085", "l": "arabinogalactan binding", "d": ["Binding to arabinogalactan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189062", "l": "lactose + H2O => D-glucose + D-galactose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51751", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A <=> 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25700", "l": "(E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-hexahomomethionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18479", "l": "2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+) => 2,3-dihydroxybenzoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44394", "l": "1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420980", "l": "Activation of Ca permeable AMPA receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60157", "l": "ATP + D-galactose(out) + H2O => ADP + D-galactose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047466", "l": "2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase activity", "d": ["Catalysis of the reaction: cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12021", "l": "a monocarboxylic acid amide + H2O => a monocarboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21538", "l": "3-methyl-(2E)-glutaconyl-CoA + H2O => (3S)-hydroxy-3-methylglutaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0016427", "l": "tRNA (cytosine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955844", "l": "RBKS phosphorylates ribose to R5P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68367", "l": "4-CDP-2-C-methyl-D-erythritol <=> 2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42285", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11174", "l": "(6S)-5,6,7,8-tetrahydrofolate + L-methionine => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56878", "l": "(R)-1-phenylethylamine + acetate => (R)-N-acetyl-1-phenylethylamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0022810", "l": "membrane potential driven uniporter activity", "d": ["Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57415", "l": "AMP + diphosphate + L-tyrosinal + NADP(+) <=> ATP + H(+) + L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140764", "l": "small RNA binding translational repressor activity", "d": ["A translational repressor activity that binds to a single-stranded small regulatory RNA (either a miRNA or a siRNA) to guide it to its target mRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52746", "l": "alpha-isomaltosyl-(1->3)-isomaltose => cyclobis-(1->3)-alpha-D-isomaltosyl + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51210", "l": "12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH => 20-hydroxy-leukotriene B4 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018616", "l": "trihydroxytoluene dioxygenase activity", "d": ["Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49145", "l": "2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose => dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951644", "l": "Release of mature NEDD8 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65972", "l": "a peptide antigen(in) + ATP + H2O = a peptide antigen(out) + ADP + H(+) + phosphate", "d": []}, {"i": "EC:7.4.2.14", "l": "\"ABC-type antigen peptide transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111956", "l": "Calmodulin activates Cam-PDE 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35789", "l": "H(+) + kanamycin C + UDP => paromamine + UDP-alpha-D-kanosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14988", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008725", "l": "DNA-3-methyladenine glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47242", "l": "(2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22206", "l": "H2O + homogentisate + NADP(+) => 3-hydroxyphenylacetate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12333", "l": "ATP + Fe(3+)(out) + H2O => ADP + Fe(3+)(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163310", "l": "TFAM binds to mitochondrial promoters (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690873", "l": "ACO1 binds 4Fe-4S (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37864", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA => 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578712", "l": "Importin-8 binds AGO2:miRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27798", "l": "(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = all-trans-octaprenyl diphosphate + 5 diphosphate", "d": []}, {"i": "EC:2.5.1.90", "l": "\"all-trans-octaprenyl-diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48749", "l": "D-threitol + NAD(+) => D-erythrulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871226", "l": "RET binds GFRA1,GFRA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19609", "l": "adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.182", "l": "\"16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42020", "l": "11-dehydrocorticosterone + NAD(+) = H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75422", "l": "(R,S)-butane-2,3-diol + NAD(+) <=> (S)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39667", "l": "a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a ketone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.1.98.5", "l": "\"secondary-alcohol dehydrogenase (coenzyme-F420)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018556", "l": "2,2',3-trihydroxybiphenyl dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxybenzenoid + O2 = H+ + distal extradiol ring cleavage. Substrates are 2,2',3-trihydroxybiphenyl (forms 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate) and 2,2',3-trihydroxydiphenylether (forms 2,3-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858252", "l": "HDLBP binds HDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38296", "l": "(R)-2-hydroxyglutarate + A => 2-oxoglutarate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51617", "l": "ATP + formate + H(+) => CO2 + dATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9645598", "l": "RRAGC,D hydrolyzes GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43179", "l": "cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68512", "l": "(2Z,6Z)-farnesyl diphosphate = alpha-acoradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72712", "l": "cathenamine + H(+) => 4,21-dehydrogeissoschizine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1963589", "l": "ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23932", "l": "an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667456", "l": "AVPR1A,B bind desmopressin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0001228", "l": "DNA-binding transcription activator activity, RNA polymerase II-specific", "d": ["A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40758", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694421", "l": "PP6 dephosphorylates SEC24 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66354", "l": "(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH => (3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26374", "l": "[thioredoxin]-disulfide + prostamide F2alpha => [thioredoxin]-dithiol + prostamide H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134954", "l": "DHX9 binds DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047526", "l": "2'-hydroxyisoflavone reductase activity", "d": ["Catalysis of the reaction: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21624", "l": "FMNH2 + NADP(+) = FMN + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48439", "l": "H2O + pentanoate ester <=> an aliphatic alcohol + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64421", "l": "H(+)(out) + L-alanyl-L-proline(out) => H(+)(in) + L-alanyl-L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17224", "l": "dTDP-alpha-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62599", "l": "(S)-8-oxocitronellyl enol + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59922", "l": "(2E)-octenoate + 2 H(+) + NADH => (2E)-octenal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20071", "l": "H2O + phenylacetonitrile => (Z)-phenylacetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070406", "l": "glutamine binding", "d": ["Binding to glutamine, 2,5-diamino-5-oxopentanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35332", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) => (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44299", "l": "2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA <=> 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-264458", "l": "Proteasome mediated degradation of COP1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0061459", "l": "L-arginine transmembrane transporter activity", "d": ["Enables the transfer of L-arginine from one side of a membrane to the other."]}, {"i": "RHEA:32143", "l": "L-arginine(in) = L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37866", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA <=> 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50414", "l": "H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678843", "l": "ISGylation of protein translation regulator 4EHP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621242", "l": "CITED2 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714691", "l": "RAC3 binds ER effectors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437230", "l": "L1-FGFR cis-heterodimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19588", "l": "lithocholate + NAD(+) <=> 3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607002", "l": "Activated protein C cleaves factor VIIIa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16954", "l": "2-oxoglutarate + N(2)-succinyl-L-ornithine => L-glutamate + N-succinyl-L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34588", "l": "2-oxoglutarate + O2 + pentalenolactone E => CO2 + pentalenolactone F + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375141", "l": "Neogenin:Netrin-3 binds CDO complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58794", "l": "ADP + Fe(III)-petrobactin(in) + H(+) + phosphate => ATP + Fe(III)-petrobactin(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56610", "l": "L-serine + tetrahydrosulfopterin => 5,10-methylenetetrahydrosulfopterin + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975633", "l": "atROL binds to RBP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-398040", "l": "Gbeta:gamma activation of PLC beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50585", "l": "13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) => 15-oxoprostaglandin E1 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623384", "l": "α1-agonists bind ADRA1A,B,D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43645", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-CoA => 3-oxohexadecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44828", "l": "(R)-carnitine + decanoyl-CoA = CoA + O-decanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74723", "l": "Endosome acidification (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36565", "l": "GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH => GDP-beta-L-colitose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52944", "l": "cholate + UDP-alpha-D-glucuronate = choloyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-708349", "l": "Activated NOD2 oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36916", "l": "(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10323", "l": "trans-3-hydroxy-L-proline <=> 1-pyrroline-2-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31520", "l": "O2 + torulene => 3-methyl-2-butenal + 4'-apo-beta-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.133", "l": "\"glucan 1,4-alpha-maltohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44461", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol => a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864577", "l": "TFAP2C translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654511", "l": "FGFRL1 dimer binds FGFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14214", "l": "ATP + beta-D-fructose 1-phosphate => ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48573", "l": "3,5-dichlorocatechol + O2 => (2E,4E)-2,4-dichloromuconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41335", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51534", "l": "5-hydroxyisourate + H2O + NADP(+) => H(+) + NADPH + O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050020", "l": "L-arabinonate dehydratase activity", "d": ["Catalysis of the reaction: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018756", "l": "RHOH binds GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37834", "l": "(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 <=> 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30690", "l": "(4R)-4-hydroxy-2-oxoglutarate <=> glyoxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28625", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol => (-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611839", "l": "β3-agonists bind ADRB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706304", "l": "Active FLT3 binds to GRAP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13886", "l": "H2O + stipitatonate => CO2 + stipitatate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183122", "l": "Factor D cleaves C3b-bound Factor B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14813", "l": "L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam", "d": []}, {"i": "EC:5.1.1.15", "l": "\"2-aminohexano-6-lactam racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17653", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.29", "l": "\"geranylgeranyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-481044", "l": "Surface deployment of platelet alpha granule membrane components (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28870", "l": "H(+)(in) + lactose(in) <=> H(+)(out) + lactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43748", "l": "ATP + CoA + hexacosanoate = AMP + diphosphate + hexacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22275", "l": "(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] <=> (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944240", "l": "Association of procollagen type III (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64808", "l": "acetyl-CoA + O-(2-aminoethyl)-L-serine = CoA + H(+) + O-(2-acetamidoethyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9659611", "l": "ANO1 inhibitors bind ANO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10831", "l": "anthranilate + ATP + CoA <=> AMP + anthraniloyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351341", "l": "Exocytosis of Proactivator polypeptide (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43204", "l": "cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.227", "l": "\"16S rRNA (cytidine(1409)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803890", "l": "SFN dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57350", "l": "3-hydroxy-4-methylanthranilate + H(+) + L-alanine => 3-hydroxy-4-methyl-L-kynurenine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34757", "l": "D-glucose + N-acyl-15-methylhexadecasphing-4-enine => H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654399", "l": "Activated FGFR2 binds FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909732", "l": "Phosphorylation of STAT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53554", "l": "18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655170", "l": "RCHY1 monoubiquitinates POLH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57971", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686587", "l": "ABL1 phosphorylates RAD52 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20022", "l": "2-oxoglutarate + deoxyamidinoproclavaminate + O2 => amidinoproclavaminate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202216", "l": "Phosphorylation of SLP-76 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12609", "l": "mercaptopurine + S-adenosyl-L-methionine = 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21088", "l": "2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 = a flavonol + CO2 + H2O + succinate", "d": []}, {"i": "EC:1.14.20.6", "l": "\"flavonol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30118", "l": "decanoyl-[ACP] + H2O <=> decanoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433506", "l": "Phosphorylation of APS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781905", "l": "ZRANB1 binds APC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17161", "l": "2,6-dioxo-6-phenylhexa-3-enoate + H2O = 2-oxopent-4-enoate + benzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37833", "l": "2-methyl-4-chlorophenol + CO2 + pyruvate + succinate => (S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13397", "l": "6-oxohexanoate + H2O + NADP(+) = 2 H(+) + hexanedioate + NADPH", "d": []}, {"i": "EC:1.2.1.63", "l": "\"6-oxohexanoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9648268", "l": "HTR1A binds HTR1A antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848726", "l": "PTK6 phosphorylates BCAR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856808", "l": "Recruitment of AP-2 complex and clathrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031546", "l": "brain-derived neurotrophic factor receptor binding", "d": ["Binding to a brain-derived neurotrophic factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67058", "l": "chermesin D methyl ester + S-adenosyl-L-homocysteine => chermesin D + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.98.2", "l": "\"bacteriochlorophyllide c C-7(1)-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34049", "l": "6'''-deamino-6'''-oxoneomycin C + H2O2 => 6'''-deamino-6'''-hydroxyneomycin C + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54246", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49124", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate = H2O + NADP(+) + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64463", "l": "acetyl phosphate + L-lysyl-[protein] <=> H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635609", "l": "Rv3655c binds RNF213 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68546", "l": "(E)-beta-farnesene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625421", "l": "The anterograde IFT train dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684008", "l": "NBN binds KPNA2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15306", "l": "betaine aldehyde + H2O + NAD(+) => glycine betaine + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61684", "l": "glycero-2-phosphocholine + H2O = glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60727", "l": "dodecanal + H2O + NADP(+) <=> dodecanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37146", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61819", "l": "16,17-didehydropregnenolone + UDP-alpha-D-glucose <=> 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474266", "l": "Formation of collagen fibrils (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74811", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40896", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15225", "l": "alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose", "d": []}, {"i": "EC:2.7.7.24", "l": "\"glucose-1-phosphate thymidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46034", "l": "(2S)-hydroxytetradecanoate + H2O => H2O2 + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249378", "l": "STING recruits TBK1 and STAT6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9702818", "l": "CALCR binds erenumab (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031880", "l": "type 3 somatostatin receptor binding", "d": ["Binding to a type 3 somatostatin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39706", "l": "(2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH <=> (13Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68829", "l": "borneol + NAD(+) => camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052658", "l": "inositol-1,4,5-trisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9686930", "l": "RIPK3 is cleaved by CASP8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30723", "l": "A + 2 ADP + H(+) + NH4(+) + 2 phosphate = AH2 + 2 ATP + H2O + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71263", "l": "chloride(out) + L-proline(out) + 2 Na(+)(out) = chloride(in) + L-proline(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167090", "l": "7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799329", "l": "Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852324", "l": "GTSE1 binds PLK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373741", "l": "SDK2 homophillic interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62980", "l": "(9Z)-hexadecenamide + H2O = (9Z)-hexadecenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15358", "l": "5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose => demethyllactenocin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19892", "l": "alpha-D-glucose 1-phosphate + H(+) + UTP <=> diphosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821368", "l": "AKAP8L binds MLL1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20372", "l": "betaine aldehyde + H2O + O2 <=> glycine betaine + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58416", "l": "(E)-4-hydroxynon-2-en-1-ol + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30998", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41002", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209187", "l": "Further phosphorylation of CI by CKIalphaepsilon (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56515", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59706", "l": "D-cellohexaonate + H(+) => D-cellohexaono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878054", "l": "HIPK2 phosphorylates RUNX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.-", "l": "\"Carboxylic ester hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0003688", "l": "DNA replication origin binding", "d": ["Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9714580", "l": "SLC6A3 binds DRIs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34216", "l": "4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) => 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602466", "l": "Activation of MT-MMPs by FURIN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975594", "l": "PLB1 hydrolyses RPALM to atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047833", "l": "D-sorbitol dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30922", "l": "A + rhodopin <=> (3E)-3,4-didehydrorhodopin + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035255", "l": "ionotropic glutamate receptor binding", "d": ["Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954082", "l": "E2F6 binds the PRC1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60038", "l": "3-hydroxy-3-methylhexanoate + L-glutamine => H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10778", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017075", "l": "syntaxin-1 binding", "d": ["Binding to a syntaxin-1 SNAP receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13199", "l": "H2O + UDP-alpha-D-6-sulfoquinovose => H(+) + sulfite + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001094", "l": "TFIID-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58415", "l": "3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin] <=> H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62529", "l": "digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) => dihydrodigoxin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3204311", "l": "AOX1 oxidises PXL to PDXate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23404", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": []}, {"i": "EC:2.5.1.41", "l": "\"phosphoglycerol geranylgeranyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36569", "l": "GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH => GDP-beta-L-colitose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42794", "l": "cholesteryl hexadecanoate + CoA => cholesterol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28067", "l": "CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) => alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222020", "l": "NUAK1 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25486", "l": "(1S,4R)-camphene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15248", "l": "a monoacylglycerol + H2O <=> a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5444523", "l": "Formation of MSH1:PMS2 Complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71259", "l": "2 Na(+)(out) + phosphate(out) = 2 Na(+)(in) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47772", "l": "a guanosine in 21S rRNA + S-adenosyl-L-methionine = a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75768", "l": "(9Z)-hexadecenoate + H2O => 10-hydroxyhexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45545", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67835", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(27)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(27)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66455", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+) <=> 1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2990882", "l": "CDK1 phosphorylates NUP98 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033777", "l": "lithocholate 6beta-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + lithocholate + NADPH + O2 = 6-beta-hydroxylithocholate + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140580", "l": "mitochondrion autophagosome adaptor activity", "d": ["The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome during mitophagy."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103117", "l": "UDP-3-O-acyl-N-acetylglucosamine deacetylase activity", "d": ["Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetylglucosamine(2-) + H2O <=> UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853405", "l": "TPX2 binds AURKA at centrosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71456", "l": "goralatide + H2O => L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210935", "l": "Furin cleaves ANTXR1-bound pagA to yield pagA(197-794) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32346", "l": "(+)-thujan-3-ol + NAD(+) <=> (+)-thujan-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380508", "l": "Translocation of NuMA to the centrosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001081", "l": "(1->4)-beta-D-galactan binding", "d": ["Binding to (1->4)-beta-D-galactan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20858", "l": "a fatty acid + sphing-4-enine => an N-acylsphing-4-enine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9703895", "l": "CASR binds CASR agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70193", "l": "3'-NADP(+) + ADP + H(+) => ATP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23726", "l": "4-pyridoxate + H(+) + H2O2 => H2O + O2 + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610726", "l": "The IFT-A complex recruits TULP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0004308", "l": "exo-alpha-sialidase activity", "d": ["Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43891", "l": "[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine <=> [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038944", "l": "Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865491", "l": "RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23062", "l": "a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate => a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381537", "l": "PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55509", "l": "cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46543", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46656", "l": "androst-4-ene-3,17-dione + H(+) + NADPH = 5beta-androstane-3,17-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167474", "l": "Abortive HIV-1 Initiation Before Second Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35651", "l": "(4R)-hydroxysphinganine + a fatty acyl-CoA = an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030370", "l": "intercellular adhesion molecule-3 receptor binding", "d": ["Binding to a receptor for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19219", "l": "1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+) => 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69140", "l": "RPA binds to the Flap (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0008251", "l": "tRNA-specific adenosine deaminase activity", "d": ["Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879942", "l": "The receptor is activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604722", "l": "Activation of proMMP9 by proteases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030172", "l": "troponin C binding", "d": ["Binding to troponin C, the calcium-binding subunit of the troponin complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41062", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382054", "l": "PDGF binds to extracellular matrix proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9035484", "l": "CysS248-MPST:TXN2 dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55617", "l": "a carotenoid psi-end group => a carotenoid epsilon-end group", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168046", "l": "Collagen type XII degradation by MMP12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70761", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28058", "l": "L-lyxopyranose = L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17479", "l": "CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine => precorrin-6B + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73031", "l": "Cd(2+)(out) + H(+)(out) = Cd(2+)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69693", "l": "ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP => ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23109", "l": "D-arabinono-1,4-lactone + H2O => D-arabinonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36051", "l": "beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O = 2 beta-L-arabinofuranose", "d": []}, {"i": "EC:3.2.1.185", "l": "\"non-reducing end beta-L-arabinofuranosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72998", "l": "L-fucose(out) + 2 Na(+)(out) <=> L-fucose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35349", "l": "(2E)-octadecenoyl-CoA + H2O => 3-hydroxyoctadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805205", "l": "GPR35 binds kynurenic acid (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67964", "l": "4-methylamino-L-phenylalanine + S-adenosyl-L-methionine = 4-dimethylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59115", "l": "ATP + L-serine <=> ADP + H(+) + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034530", "l": "4-hydroxymethylsalicyaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 4-hydroxymethylsalicylaldehyde + NAD+ + H2O = 4-hydroxymethylsalicylate + NADH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179413", "l": "Activated PKC-alpha  activate MMP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24334", "l": "H2O + monacolin L carboxylate => 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.3", "l": "\"haloacetate dehalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9676257", "l": "Formation of the SET1A complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102181", "l": "4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 <=> 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047448", "l": "5-dehydro-4-deoxyglucarate dehydratase activity", "d": ["Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucarate + H+ = 2,5-dioxopentanoate + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35948", "l": "dihydrochanoclavine-I aldehyde + NADP(+) => chanoclavine-I aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665761", "l": "FMNL3 binds RHOC:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19511", "l": "2 H(+) + L-erythro-biopterin + 2 NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71689", "l": "glycyl-L-aspartate(in) + 2 H(+)(in) => glycyl-L-aspartate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3965450", "l": "DAAM1 recruits PFN1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.-.-", "l": "\"Other lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9611852", "l": "ADRB3 bind ADR,NAd (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5220959", "l": "TDG excises 5-formylcytosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42768", "l": "a (2S)-2-hydroxycarboxylate + NADP(+) = a 2-oxocarboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445714", "l": "Aquaporin-3 passively transports water out of cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69231", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate <=> an epithionitrile + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9655046", "l": "Cleavage of FXII variant by KLKB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141437", "l": "Formation of the MCC complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198732", "l": "STAT3 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416690", "l": "SEMA4A binds to PLXND1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34224", "l": "6-hydroxypseudooxynicotine + A + H2O => 2,6-dihydroxypseudooxynicotine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70876", "l": "L-glutamine(in) + L-methionine(out) + Na(+)(out) => L-glutamine(out) + L-methionine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19125", "l": "glyoxylate + L-serine = 3-hydroxypyruvate + glycine", "d": []}, {"i": "EC:2.6.1.45", "l": "\"serine--glyoxylate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48141", "l": "2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23617", "l": "1,2-dihydro-alpha-santonin + NADP(+) => alpha-santonin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17525", "l": "biuret + H2O = NH4(+) + urea-1-carboxylate", "d": []}, {"i": "EC:3.5.1.84", "l": "\"biuret amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2399913", "l": "atRAL binds to RBP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71050", "l": "Trimerization of the FASL:FAS receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.-", "l": "\"Dipeptide hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46554", "l": "a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.-", "l": "\"Endodeoxyribonucleases producing 5'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68569", "l": "N(5)-hydroxy-L-ornithine => (3S)-1,2-diazinane-3-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34559", "l": "1-deoxy-11beta-hydroxypentalenate + NAD(+) = 1-deoxy-11-oxopentalenate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.340", "l": "\"1-deoxy-11beta-hydroxypentalenate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70465", "l": "a 2'-deoxyadenosine in double-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981353", "l": "RASA1 stimulates RAS GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61554", "l": "gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58425", "l": "(E)-hex-2-en-1-ol + NADP(+) => (E)-hex-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47023", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O <=> [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514865", "l": "cGMP dissociates from CNG channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209823", "l": "Tyrosine is hydroxylated to dopa (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8934465", "l": "SHC1 binds PTPN12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75460", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199579", "l": "KIR2DL4 interacting with HLA-G (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38022", "l": "(9Z)-octadecenoyl-CoA + 1-decanoylglycerol <=> 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187575", "l": "Ubiquitination of phospho-p27/p21 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374337", "l": "Apelin receptor binds to apelin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018572", "l": "EGFR phosphorylates NOTCH3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43135", "l": "N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41229", "l": "4-hydroxyphenylglyoxylate + H2O2 => (S)-4-hydroxymandelate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36566", "l": "GDP-beta-L-colitose + NADP(+) <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060241", "l": "lysozyme inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of lysozyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36498", "l": "alpha-D-glucose + ATP <=> ADP + alpha-D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018520", "l": "cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ = 4-methylcatechol + NADPH + H+ + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37094", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632646", "l": "SMURF1/2 bind PTCH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14082", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate => D-glyceraldehyde 3-phosphate + indole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382057", "l": "Release of novel PDGFs as latent factors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170674", "l": "Dissociation of the Gi alpha:G olf complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20542", "l": "H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 => 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645535", "l": "ALPK1 phosphorylates TIFA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982017", "l": "Active G alpha (q) binds RGS proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16707", "l": "estrone + H(+) + NADPH => 17alpha-estradiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10229", "l": "citrate => cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59007", "l": "dodecanal + H2O + O2 <=> dodecanoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20140", "l": "10-deacetylbaccatin III + acetyl-CoA <=> baccatin III + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23382", "l": "H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20620", "l": "L-galactono-1,4-lactone + O2 <=> H(+) + H2O2 + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32138", "l": "2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19756", "l": "ATP + diphthine-[translation elongation factor 2] + NH4(+) <=> AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693347", "l": "CRYM reduces P2C to PPCA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58953", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose => (20S)-ginsenoside Rh1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3159259", "l": "MMAA:MUT binds AdoCbl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68769", "l": "4 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022F + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9690461", "l": "FKBP1A binds tacrolimus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784189", "l": "JAKs bind LIFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4647594", "l": "SAHF formation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12129", "l": "2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165162", "l": "Phosphorylation of TSC2 by PKB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53161", "l": "H2O + N-acyl-sn-glycero-3-phosphoethanolamine => an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69422", "l": "H2O + hypoiodite => H2O2 + iodide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30983", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] = beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15984", "l": "H(+) + S-adenosyl-L-methionine <=> CO2 + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35658", "l": "2 ATP <=> 3',3'-c-di-AMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052908", "l": "16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity", "d": ["Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61439", "l": "ADP + H2O <=> AMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047321", "l": "diphosphate-protein phosphotransferase activity", "d": ["Catalysis of the reaction: microsomal-membrane protein + diphosphate = diphosphate + O-phospho-microsomal-membrane protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33342", "l": "(4R)-hydroxysphinganine + hexacosanoyl-CoA <=> CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40206", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11582", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24032", "l": "sucrose = 6-O-alpha-D-glucopyranosyl-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42510", "l": "5-acetamidopentanoate + CO2 + H(+) + NADH => 6-acetamido-2-oxohexanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112435", "l": "Formation of Elongin BC complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110237", "l": "MUTYH mediated recognition and binding of an adenine opposite to an 8-oxoguanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351901", "l": "Caspase-mediated cleavage of MST3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37282", "l": "ATP + H2O + L-alanyl-L-histidine(out) <=> ADP + H(+) + L-alanyl-L-histidine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018766", "l": "RHOU binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13104", "l": "4-imidazolone-5-propanoate <=> H2O + trans-urocanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110219", "l": "Cleavage of thymine by TDG glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30066", "l": "2-demethylmenaquinol-8 + S-adenosyl-L-methionine <=> H(+) + menaquinol-8 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71600", "l": "2-oxoglutarate(out) + maleate(in) => 2-oxoglutarate(in) + maleate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29820", "l": "ATP + H2O + L-isoleucine(out) => ADP + H(+) + L-isoleucine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0005375", "l": "copper ion transmembrane transporter activity", "d": ["Enables the transfer of copper (Cu) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9709109", "l": "DHFR dimer binds DHFR inhibitors (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15638", "l": "[alginate](n) + GDP-alpha-D-mannuronate => [alginate](n+1) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77609", "l": "Binding of APOBEC-1 to form editosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63148", "l": "H2O + N-(9Z-octadecenoyl)-taurine = (9Z)-octadecenoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140395", "l": "averantin hydroxylase activity", "d": ["Catalyzes the reaction: (1'S)-averantin + [reduced NADPH--hemoprotein reductase] + O2 <=> (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH--hemoprotein reductase] + H2O. Involved in aflatoxin biosynthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444433", "l": "Cho transports from the extracellular space to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627089", "l": "CASP9 is phosphorylated at T412 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507870", "l": "Aquaporins passively transport water out of cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.093101469280398", "identifiers": [{"i": "GO:0140828", "l": "metal cation:monoatomic cation antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(in) = solute(in) + Na+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451839", "l": "DCO binds to FT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612444", "l": "ERBB4s80 binds STMN1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050142", "l": "nitrogenase (flavodoxin) activity", "d": ["Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156699", "l": "Inactivation of Wee1 kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41248", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48725", "l": "aurachin B + H(+) + H2O => 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68483", "l": "(2R)-2-hydroperoxyhexadecanoate + H(+) <=> CO2 + H2O + pentadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24356", "l": "a 1-acyl-sn-glycero-3-phosphocholine = a 2-acyl-sn-glycero-3-phosphocholine", "d": []}, {"i": "EC:5.4.1.1", "l": "\"lysolecithin acylmutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862771", "l": "PLA2G2A binds bacterial phospholipids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043428", "l": "2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-heptaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-heptaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.17", "l": "\"tetrahydrofolate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44984", "l": "(R)-carnitine + 3-methylbutanoyl-CoA = CoA + O-3-methylbutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65821", "l": "decanoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => dec-9-enoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445699", "l": "ATP Hydrolysis By Myosin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16801", "l": "3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] = adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]", "d": []}, {"i": "EC:2.8.2.20", "l": "\"protein-tyrosine sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001790", "l": "polymeric immunoglobulin binding", "d": ["Binding to a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32332", "l": "(1S,2S,4R)-endo-fenchol + NAD(+) => (1S,4R)-fenchone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66478", "l": "gypsogenate 28-beta-D-glucoside + UDP => gypsogenate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44874", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901480", "l": "oleate transmembrane transporter activity", "d": ["Enables the transfer of oleate from one side of a membrane to the other."]}, {"i": "RHEA:33655", "l": "(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912627", "l": "CBL ubiquitinates PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31995", "l": "(2E,6E)-farnesyl diphosphate = 7-epi-sesquithujene + diphosphate", "d": []}, {"i": "EC:4.2.3.101", "l": "\"7-epi-sesquithujene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818574", "l": "TASP1 cleaves KMT2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74915", "l": "a (2E)-enoyl fatty acid + ATP + H(+) = a (2E)-2-fatty-enoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605591", "l": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446634", "l": "IRAK4 is activated by autophosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21252", "l": "(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2", "d": []}, {"i": "EC:1.1.99.2", "l": "\"L-2-hydroxyglutarate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40400", "l": "1,2-dihydro-beta-NADP + H(+) + O2 => H2O2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68304", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] = 3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050074", "l": "malate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + malate + CoA = ADP + phosphate + malyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48731", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37184", "l": "(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate => 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944261", "l": "Association of procollagen type XIII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46292", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+) = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663265", "l": "NR1D1 (REV-ERBA) binds heme, the NR1D1 gene, and recruits corepressors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20910", "l": "3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP => 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749505", "l": "LRRC14 binds IKBKB and CHUK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950741", "l": "IL12B:IL23A translocates from ER lumen to extracellular space (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177937", "l": "Phosphorylation of EGFR by SRC kinase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-708349", "l": "Activated NOD2 oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36194", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.69", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14320", "l": "morphine + NAD(+) <=> H(+) + morphinone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71194", "l": "an L-alpha-amino acid(in) + L-kynurenine(out) <=> an L-alpha-amino acid(out) + L-kynurenine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14045", "l": "1-carboxyvinyl carboxyphosphonate + H(+) = 3-(hydrohydroxyphosphoryl)pyruvate + CO2", "d": []}, {"i": "EC:2.7.8.23", "l": "\"carboxyvinyl-carboxyphosphonate phosphorylmutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63739", "l": "2-phenylacetaldehyde + H(+) + NADPH <=> 2-phenylethanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50522", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55184", "l": "2-oxoglutarate + 3-methylundecanoyl-CoA + O2 = 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.5", "l": "\"dipeptidyl-peptidase IV\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27748", "l": "CO2 + cysteamine => H(+) + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12061", "l": "acetyl-CoA + 5 H(+) + 6 malonyl-CoA => 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202717", "l": "Heterodimerization of CEACAMs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18115", "l": "a ribonucleoside 5'-triphosphate + ADP => a ribonucleoside 5'-diphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22871", "l": "3-chloro-L-alanine + thioglycolate <=> chloride + H(+) + S-carboxymethyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "45.521726681223541", "identifiers": [{"i": "GO:0016740", "l": "transferase activity", "d": ["Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0003940", "l": "L-iduronidase activity", "d": ["Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806629", "l": "Formation of tonofilament bundles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429529", "l": "Thrombin binding to GP1b:IX:V (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419841", "l": "Light stimulates opsin receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34076", "l": "an acyl phosphate + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31034", "l": "2-cis-(+)-abscisate + UDP-alpha-D-glucose <=> beta-D-glucopyranosyl cis-(+)-abscisate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21663", "l": "benzaldehyde + H2O + NADP(+) <=> benzoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4837364", "l": "Secretion of SOD3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668904", "l": "Formation of the CTF18 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.967242924124768", "identifiers": [{"i": "GO:0015103", "l": "inorganic anion transmembrane transporter activity", "d": ["Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40380", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65300", "l": "2-oxoglutarate + chrodrimanin C + O2 = CO2 + H2O + succinate + verruculide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60659", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.35", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27907", "l": "butanoyl-CoA + NADP(+) => (2E)-butenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-354060", "l": "Translocation of RIAM to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033879", "l": "acetylajmaline esterase activity", "d": ["Catalysis of the reactions: 17-O-acetylajmaline + H2O = ajmaline + acetate, and 17-O-acetylnorajmaline + H2O = norajmaline + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37818", "l": "(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 <=> 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20137", "l": "10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA", "d": []}, {"i": "EC:2.3.1.167", "l": "\"10-deacetylbaccatin III 10-O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210959", "l": "Endocytosis of cya:lef:(pagA(197-794):ANTXR2 oligomer) (plasma membrane to endosome membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374723", "l": "Nociceptin receptor binds to nociceptin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55643", "l": "C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate <=> AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74513", "l": "aspoquinolone A => (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11317", "l": "an aliphatic aldoxime => a nitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51108", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43245", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55427", "l": "(3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] <=> (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17738", "l": "NADP(+) + shikimate => 3-dehydroshikimate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23275", "l": "an N(6)-alkylaminopurine + UDP-alpha-D-glucose <=> an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696271", "l": "RND1 binds effectors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75756", "l": "(10E)-octadecenoate + H2O => 10-hydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592234", "l": "Expression of GABPA (NRF2 alpha subunit) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2430535", "l": "MASTL phosphorylates ENSA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807008", "l": "PTPRJ dephosphorylates MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202127", "l": "eNOS synthesizes NO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012196", "l": "KPNA2 translation is negatively regulated by miR-26A and B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29365", "l": "2'-deoxycytidine + phosphate => dCMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70762", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789960", "l": "Expression of NDN,TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730903", "l": "Oligomerization of TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624954", "l": "INPP5E translocates to the primary cilium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33853", "l": "GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine => GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73871", "l": "(R)-noradrenaline(out) = (R)-noradrenaline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617535", "l": "Activated calmodulin binds ADCY1,ADCY8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008442", "l": "3-hydroxyisobutyrate dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875816", "l": "STAT3 binds activated MET receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203979", "l": "Coat Assembly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669854", "l": "KIT binds type II TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47845", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) => CO2 + diphosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106414", "l": "mRNA dihydrouridine synthase activity", "d": ["Catalysis of the reaction: mRNA-uracil + NAD(P)+ = mRNA-dihydrouridine + NAD(P)H+ + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58050", "l": "2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA => 2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166542", "l": "beta-NGF dimer binds to TrkA receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63127", "l": "H2O + N-octadecanoyl ethanolamine <=> ethanolamine + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29545", "l": "a dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102645", "l": "17(E)-cheilanthenediol synthase activity", "d": ["Catalysis of the reaction: 17(E)-cheilanthenediol <=> all-trans-geranylfarnesol + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25029", "l": "ADP-alpha-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate", "d": []}, {"i": "EC:3.1.3.84", "l": "\"ADP-ribose 1''-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050144", "l": "nucleoside deoxyribosyltransferase activity", "d": ["Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186773", "l": "PDGF dimer binds two receptors simultaneously (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009011", "l": "starch synthase activity", "d": ["Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54033", "l": "(6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose => (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40008", "l": "(+)-copalyl diphosphate + H2O => (+)-copalol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678843", "l": "ISGylation of protein translation regulator 4EHP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38425", "l": "(9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+) => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31093", "l": "3-oxotetradecanoyl-CoA + CoA => acetyl-CoA + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59861", "l": "3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005340", "l": "nucleotide-sulfate transmembrane transporter activity", "d": ["Enables the transfer of nucleotide-sulfate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61852", "l": "campesterol + UDP-alpha-D-glucose = campesteryl 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1364044", "l": "PRLR:JAK2 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55249", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36579", "l": "dTDP-alpha-D-fucose + NAD(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033447", "l": "AGA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AGA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65748", "l": "2-oxoglutarate + dodecyl sulfate + O2 = CO2 + dodecanal + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52857", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44809", "l": "1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) => 2-demethylmenaquinol-10 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31843", "l": "2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA = 2-oxepin-2(3H)-ylideneacetyl-CoA", "d": []}, {"i": "EC:5.3.3.18", "l": "\"2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508513", "l": "PTK2B binds JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003833", "l": "beta-alanyl amine synthase activity", "d": ["Catalysis of the synthesis of beta-alanyl amine conjugate from a precursor biogenic amine, such as dopamine or histamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75977", "l": "(S)-cis-N-methylstylopine + S-adenosyl-L-homocysteine => (S)-stylopine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696183", "l": "AOC3 deaminates BZAM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66047", "l": "2-oxobutanoate + L-kynurenine <=> (2S)-2-aminobutanoate + H2O + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64456", "l": "L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.372", "l": "\"[histone H4]-lysine(20) N-trimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.33", "l": "\"RCR-type E3 ubiquitin transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029468", "l": "Conversion of PA into DAG by PAP-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609917", "l": "Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687097", "l": "p-S857 NCOA3 binds ETV4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0141057", "l": "histone H3 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H3 L-arginyl = histone H3 L-citrullyl + NH4+, resulting in histone H3 citrullination."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33439", "l": "glyoxal + H2O + O2 = glyoxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73757", "l": "Binding of RRN3 to RNA Polymerase I (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74278", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid A <=> a 2-acyl-sn-glycero-3-phosphocholine + a hepta-acyl lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73433", "l": "(2S)-7-methylcarthamidin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-sakuranetin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36179", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-choline = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034845", "l": "naphthyl-2-methyl-succinyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: naphthyl-2-methyl-succinyl-CoA = naphthyl-2-methylene-succinyl-CoA + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15243", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56219", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65312", "l": "an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.293", "l": "\"meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71241", "l": "2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+) => 2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56683", "l": "beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.87", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51867", "l": "(2E)-geranyl diphosphate + esculetin <=> 8-geranylesculetin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58139", "l": "acetate + ATP + H(+) <=> acetyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1856948", "l": "Formation of CRY:PER:Kinase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64353", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA => 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13189", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)", "d": []}, {"i": "EC:3.1.1.26", "l": "\"galactolipase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23832", "l": "an N-acyl-D-mannosamine + ATP = ADP + an N-acyl-D-mannosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5622134", "l": "CRABP1 binds atRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14316", "l": "2-iodophenol + S-adenosyl-L-methionine <=> 1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46441", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2 => A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17505", "l": "H2O + N-(long-chain fatty acyl)ethanolamine = a long-chain fatty acid + ethanolamine", "d": []}, {"i": "EC:3.5.1.60", "l": "\"N-(long-chain-acyl)ethanolamine deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12656", "l": "(S)-malate + NAD(+) <=> CO2 + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30364", "l": "fumonisin B1 + 2 H2O => (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43550", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008569", "l": "minus-end-directed microtubule motor activity", "d": ["A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052912", "l": "23S rRNA (guanine(748)-N(1))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanine(748) in 23S rRNA = N(1)-methylguanine(748) in 23S rRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120283", "l": "protein serine/threonine kinase binding", "d": ["Binding to a protein serine/threonine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37251", "l": "cysteamine S-phosphate + H2O = cysteamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26141", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O => 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730843", "l": "Phosphorylation of LAT by p-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21127", "l": "cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50013", "l": "H(+) + NADPH + O2 + tert-butanol => 2-methylpropane-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71919", "l": "3 Na(+)(out) + succinate(out) = 3 Na(+)(in) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74688", "l": "a 2,3-di-O-phytanyl-sn-glycerophospholipid + AH2 + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + A + a macrocyclic archaeaol phospholipid + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19368", "l": "ATP + D-ribulose 5-phosphate <=> ADP + D-ribulose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450494", "l": "HuR binds mRNAs in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45539", "l": "H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68141", "l": "2,5-hexanedione + 2 H(+) + 2 NADPH => (2R,5R)-hexanediol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23609", "l": "H(+) + H2O + N-isopropylammelide => cyanurate + isopropylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013009", "l": "RHOA binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388830", "l": "PI3K binds ICOS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.14", "l": "\"2-dehydro-3-deoxy-phosphogluconate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656893", "l": "OPN1MW binds 11cRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013006", "l": "RHOA:GTP translocates to the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45392", "l": "H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49677", "l": "H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 => H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71687", "l": "glycyl-L-aspartate(out) + 2 H(+)(out) = glycyl-L-aspartate(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379974", "l": "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617840", "l": "FOXO1,FOXO3,FOXO4 bind CDKN1A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38752", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183055", "l": "Binding of CBL to EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47530", "l": "isocholate + NADP(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43881", "l": "(25S)-3beta-hydroxy-5-cholestenoate + ATP + CoA => (25S)-3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19132", "l": "ATP + thymidine <=> ADP + dTMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37820", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41270", "l": "H2O + N-(15Z-tetracosenoyl)-sphing-4-enine <=> (15Z)-tetracosenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41688", "l": "1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65245", "l": "(2S)-hesperetin + UDP-alpha-D-glucose => (2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371518", "l": "SIRT1 binds to HSF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684006", "l": "KPNA2 translocates NBN to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74941", "l": "a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + CO2 + succinate => 2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981093", "l": "IL12 bound to IL12R internalises (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45683", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) <=> N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54615", "l": "2-oxoglutarate + 3-methylbutanoyl-CoA + O2 <=> 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36071", "l": "6-tuliposide A = D-glucose + tulipalin A", "d": []}, {"i": "EC:4.2.99.22", "l": "\"tuliposide A-converting enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264865", "l": "Caspase-mediated cleavage of Lamin A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72594", "l": "D-glucuronate(out) + H(+)(out) <=> D-glucuronate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59983", "l": "8-oxo-dGTP + H2O <=> 8-oxo-dGDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17477", "l": "precorrin-6B + 2 S-adenosyl-L-methionine = CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.132", "l": "\"precorrin-6B C(5,15)-methyltransferase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102416", "l": "quercetin gentiotrioside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-gentiotrioside + UDP-alpha-D-glucose <=> quercetin-3-gentiotetraside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48375", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.13", "l": "\"3,8-divinyl protochlorophyllide a 8-vinyl-reductase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22346", "l": "(R)-rosmarinate + CoA => (2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30866", "l": "4-O-phospho-L-tyrosine + H2O <=> L-tyrosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177923", "l": "Sustained activation of SRC kinase by SHP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036382", "l": "flavin reductase (NADH) activity", "d": ["Catalysis of the reaction: a reduced flavin + NAD+ = an oxidized flavin + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801184", "l": "TP53 stimulates STEAP3 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41649", "l": "aniline + ATP + L-glutamate => ADP + N(5)-phenyl-L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928604", "l": "SFKs phosphorylate VAV2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031830", "l": "type 5A serotonin receptor binding", "d": ["Binding to a type 5A serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373705", "l": "Caspase cleavage of DCC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534378", "l": "Hv1 Mediated H+ Permeability (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033968", "l": "glutaryl-7-aminocephalosporanic-acid acylase activity", "d": ["Catalysis of the reaction: (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45629", "l": "holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein] => holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45027", "l": "cholesterol + H(+) + NADPH + O2 <=> 7-dehydrocholesterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-877187", "l": "P2X7 mediates loss of intracellular K+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016213", "l": "linoleoyl-CoA desaturase activity", "d": ["Catalysis of the reaction: (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (9Z,12Z,15Z)-octadecatrienoyl-CoA and add a fourth double bond (a (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033987", "l": "2-hydroxyisoflavanone dehydratase activity", "d": ["Catalysis of the reaction: 2,7,4'-trihydroxyisoflavanone = daidzein + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165179", "l": "Formation of TSC1:TSC2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190682", "l": "Connexin synthesis (generic) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17784", "l": "H2O + N-formyl-L-methionine <=> formate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9649108", "l": "HTR3A pentamer binds 5HT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357472", "l": "PAK1-3 autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865994", "l": "GAB1 binds PTPN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49341", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin => 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41234", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36960", "l": "D-ribono-1,4-lactone + H(+) + NADH => D-ribose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5387392", "l": "processing defective Hh variants are degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11134", "l": "H(+) + NADPH + protochlorophyllide a => chlorophyllide a + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61886", "l": "1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16565", "l": "2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate", "d": []}, {"i": "EC:2.6.1.38", "l": "\"histidine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49431", "l": "CTP + phosphonoformate <=> CMP-5'-phosphonoformate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69871", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] = (22S)-22-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710480", "l": "Decitabine triphosphate incorporates into DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163320", "l": "Association of mTERF with the termination sequence (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349455", "l": "Phosphorylation of MDM4 by ATM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198669", "l": "p38MAPK phosphorylates MSK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41592", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51807", "l": "deoxyhumulone + dimethylallyl diphosphate <=> diphosphate + H(+) + lupulone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52739", "l": "(Z)-indolylmethyl desulfoglucosinolate + 3'-phosphoadenylyl sulfate <=> (Z)-glucobrassicin + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218822", "l": "CRK binds BCAR1 and or PXN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730856", "l": "Autophosphorylation of PAK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8873923", "l": "STARD10 binds LPCAT1 and PC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37024", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20259", "l": "3-methyleneoxindole + H(+) + NADPH => 3-methyloxindole + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474210", "l": "Collagen type III degradation by MMP14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044586", "l": "cellotetraose binding", "d": ["Binding to a cellotetraose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-984733", "l": "Kinesin-3 is a dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442832", "l": "PAK phosphorylates cortactin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0070547", "l": "L-tyrosine aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71523", "l": "adenine(out) = adenine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73556", "l": "(E,E)-feruperate + O2 + reduced [NADPH--hemoprotein reductase] => (E,E)-piperate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33409", "l": "diphosphate + glycyl-5'-AMP => ATP + glycine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47261", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34683", "l": "alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O = alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+)", "d": []}, {"i": "EC:3.6.1.63", "l": "\"alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614605", "l": "Persulfide sulfur is dioxygenated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669898", "l": "KIT mutants bind type I TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17435", "l": "AH2 + betaine aldehyde => A + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047533", "l": "2,5-dioxovalerate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66496", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69864", "l": "a uridine in mRNA + S-adenosyl-L-methionine => a 5-methyluridine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043544", "l": "lipoamide binding", "d": ["Binding to lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24871", "l": "5-deoxy-alpha-D-ribose 1-phosphate + adenine => 5'-deoxyadenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322431", "l": "XIAP binds TLE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783473", "l": "LCMT2 methoxycarbonylates OHyW-72 yielding OHyW (hydroxywybutosine) at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18772", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate <=> 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17742", "l": "NAD(+) + shikimate => 3-dehydroshikimate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202375", "l": "Recruitment of ITK to SLP-76 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47753", "l": "5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine => 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003980", "l": "UDP-glucose:glycoprotein glucosyltransferase activity", "d": ["Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins."]}, {"i": "REACT:R-HSA-548884", "l": "UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132260", "l": "Complement factor I inactivates surface-bound C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62354", "l": "H2O + NADP(+) + notoamide D => H(+) + NADPH + notoamide E + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045544", "l": "gibberellin 20-oxidase activity", "d": ["Catalysis of the oxidation of C-20 gibberellins to form the corresponding C-19 lactones."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029468", "l": "Conversion of PA into DAG by PAP-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043783", "l": "oxidoreductase activity, acting on metal ions, flavin as acceptor", "d": ["Catalysis of an oxidation-reduction in which the metal ion is reduced and flavin acts as an electron acceptor."]}, {"i": "EC:1.16.8.-", "l": "\"With a flavin as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43963", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA <=> a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696274", "l": "RND1 binds GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.89", "l": "\"tRNA-dihydrouridine(47) synthase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2467794", "l": "Resolution of sister chromatids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34230", "l": "5-nitrosalicylate + O2 <=> 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13502", "l": "ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] => ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68125", "l": "a 1,2-diacylglycerol + a fatty acyl-[ACP] => a triacylglycerol + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653886", "l": "B4GALT1 binds LALBA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56461", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34708", "l": "AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015624", "l": "ABC-type ferric-enterobactin transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-enterobactin(out) = ADP + phosphate + ferric-enterobactin(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28023", "l": "ATP + holo-[ACP] + octanoate => AMP + diphosphate + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75681", "l": "(12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021596", "l": "Membrane estrogen receptors bind SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39408", "l": "3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451310", "l": "Activation of Edited Kainate receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390929", "l": "HTR1 and 5A receptors can bind serotonin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165179", "l": "Formation of TSC1:TSC2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38965", "l": "ADP + H(+) + leukotriene C4(out) + phosphate => ATP + H2O + leukotriene C4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68606", "l": "H(+) + hydroxyacetone + sulfite => (2S)-3-sulfopropanediol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140806", "l": "SERPINC1 binds SERPINC1 activators (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68247", "l": "L-phenylalanine(in) + Na(+)(in) <=> L-phenylalanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66769", "l": "ATP + coproporphyrin I(in) + H2O => ADP + coproporphyrin I(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46324", "l": "3-oxochol-4-en-22-oyl-CoA + A = 3-oxochola-4,17-dien-22-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37583", "l": "D-lysine + H2O + O2 = 6-amino-2-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9008043", "l": "MAPK8 phosphorylation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679775", "l": "COMT binds COMT Inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14368", "l": "2 H(+) + H2O + N-carbamoyl-L-aspartate <=> CO2 + L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53675", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 <=> 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676229", "l": "WIPIs bind PI3P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63044", "l": "H2O + mevastatin = H(+) + mevinic carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25656", "l": "(2S)-2-amino-3-oxobutanoate + H(+) <=> aminoacetone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11773", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987214", "l": "p-STAT3 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754974", "l": "ADK phosphorylates RBV (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73625", "l": "CTP(in) + GDP(out) => CTP(out) + GDP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750942", "l": "USP14 deubiquitinates NLRC5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5591052", "l": "PROCR binds Protein C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662613", "l": "MT3 exchanges zinc for copper (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43908", "l": "beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O = D-galactose + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62851", "l": "GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40676", "l": "L-threonine => 2-aminobut-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928645", "l": "EPHB:NMDAR binds TIAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72289", "l": "2,2-dimethylsuccinate(in) + 3 Na(+)(in) => 2,2-dimethylsuccinate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53207", "l": "17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950225", "l": "Expression of Ras-related protein Rap-1b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805426", "l": "CARD8 binds CASP9(1-416) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610722", "l": "CK1 phosphorylates p-GLI3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864595", "l": "TFAP2B homodimer binds YEATS4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708275", "l": "PDE4A binds PDE4A inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101014", "l": "[isocitrate dehydrogenase (NADP+)] phosphatase activity", "d": ["Catalysis of the reaction: [isocitrate dehydrogenase] phosphate + H2O = [isocitrate dehydrogenase] + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34832", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate => N-acyl-15-methylhexadecasphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50771", "l": "4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine <=> anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66411", "l": "ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O <=> ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75668", "l": "(11Z,14Z,17Z)-eicosatrienoate + O2 => 12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72407", "l": "H(+)(in) + Li(+)(out) = H(+)(out) + Li(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936989", "l": "RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67042", "l": "asnovolin H => (3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35532", "l": "cyclo(L-phenylalanyl-L-leucyl) + 2 O2 => albonoursin + 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-877281", "l": "PIAS1 binds p-STAT1 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19190", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate => (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28237", "l": "L-glutamate 5-semialdehyde <=> (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034547", "l": "N-cyclopropylmelamine deaminase activity", "d": ["Catalysis of the reaction: cyromazine + H2O = N-cyclopropylammeline + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47863", "l": "ganglioside GT1b (d18:1(4E)) + H2O <=> ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450088", "l": "GLUT1 tetramer binds 4xATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69053", "l": "RFC binding displaces Pol Alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389348", "l": "Activation of Rac1 by pVav1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944230", "l": "Association of procollagen type XVIII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63936", "l": "3 a ubiquinone + protoporphyrinogen IX = 3 a ubiquinol + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0008888", "l": "glycerol dehydrogenase [NAD+] activity", "d": ["Catalysis of the reaction: glycerol + NAD+ = glycerone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68155", "l": "a 1,3-diacylglycerol + a fatty acyl-CoA <=> a triacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36422", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15869", "l": "2-oxoglutarate + D-alanine = D-glutamate + pyruvate", "d": []}, {"i": "EC:2.6.1.21", "l": "\"D-amino-acid transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42156", "l": "androsterone + H(+) + NADPH = 5alpha-androstane-3alpha,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-517705", "l": "p-S318,221-HuR binds mRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30205", "l": "2 GDP + 2 H(+) => H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849428", "l": "PTPN1 binds PTK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701199", "l": "Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68942", "l": "Na(+)(out) + tellurite(out) => Na(+)(in) + tellurite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008255", "l": "ecdysis-triggering hormone activity", "d": ["The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65398", "l": "8-oxo-dAMP + diphosphate + H(+) => 8-oxo-dATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24075", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59548", "l": "N,N',N''-triacetylchitotriose + O2 = H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769323", "l": "NPAS4 stimulates NAMPT gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10937", "l": "6-decylubiquinone + 2 thiosulfate => 6-decylubiquinol + tetrathionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40904", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83677", "l": "C4 deamination of cytidine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52158", "l": "(R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60296", "l": "L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.369", "l": "\"[histone H3]-lysine(27) N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14501", "l": "H2O + L-homocysteine = 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)", "d": []}, {"i": "EC:4.4.1.2", "l": "\"homocysteine desulfhydrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38566", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + H2O <=> 1-O-hexadecyl-sn-glycerol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38143", "l": "carbon disulfide + 2 H2O = CO2 + 2 H(+) + 2 hydrogen sulfide", "d": []}, {"i": "EC:3.13.1.5", "l": "\"carbon disulfide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24575", "l": "[(1->4)-alpha-D-glucosyl](n) + sucrose <=> [(1->4)-alpha-D-glucosyl](n+1) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607747", "l": "TRAF6 binds MALT1 oligomers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38078", "l": "2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41751", "l": "3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol <=> 1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54760", "l": "ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide = 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047599", "l": "8-oxocoformycin reductase activity", "d": ["Catalysis of the reaction: coformycin + NADP+ = 8-oxocoformycin + 2 H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43596", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 = 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36290", "l": "H(+) + NADPH + O2 + theobromine <=> 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754974", "l": "ADK phosphorylates RBV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683801", "l": "CHEK2 phosphorylates BRCA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30100", "l": "1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2731141", "l": "Syndecan-1 binds fibronectin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41659", "l": "dihydrosanguinarine + NADP(+) <=> NADPH + sanguinarine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934446", "l": "Activated PKC phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22626", "l": "acetaldehyde + pyruvate => (S)-4-hydroxy-2-oxopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701485", "l": "Active ALK binds JAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13329", "l": "A + a 3-oxosteroid = a 3-oxo-Delta(1)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57710", "l": "4-O-(beta-D-glucosyl)-4-trans-coniferyl aldehyde + H(+) + UDP => (E)-coniferaldehyde + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26436", "l": "H2O + L-tryptophan => indole + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71303", "l": "RPE dimers isomerise RU5P to XY5P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443774", "l": "Trans-homodimerization of Neurofascin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25334", "l": "H2O + L-cysteinyl-tRNA(Cys) = H(+) + L-cysteine + tRNA(Cys)", "d": []}, {"i": "EC:3.6.1.n3", "l": "\"L-cysteinyl-tRNA(Cys) hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3341294", "l": "Superoxide reduces cytochrome c (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46778", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682967", "l": "WHSC1 binds DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627350", "l": "SMAC (DIABLO) binds XIAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57704", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) = 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29437", "l": "enterobactin(out) + H(+)(in) => enterobactin(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69053", "l": "RFC binding displaces Pol Alpha (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51106", "l": "13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16823", "l": "6-phospho-2-dehydro-D-gluconate + H(+) + NADH => 6-phospho-D-gluconate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686088", "l": "CASP3 cleaves GSDMD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351871", "l": "Caspase-mediated cleavage of Z0-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13215", "l": "2 H(+) + NADPH + succinate => H2O + NADP(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13525", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] = (1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": []}, {"i": "EC:1.14.15.1", "l": "\"camphor 5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390929", "l": "HTR1 and 5A receptors can bind serotonin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18497", "l": "L-ribulose 5-phosphate = L-xylulose 5-phosphate", "d": []}, {"i": "EC:5.1.3.22", "l": "\"L-ribulose-5-phosphate 3-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140812", "l": "orotate:monoatomic anion antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: orotate(out) + anion (in) = orotate (in) + anion (out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797554", "l": "ABP1 binds SHANK proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672948", "l": "MARK3 phosphorylates KSR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372529", "l": "Release of acetylcholine at the synapse (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16120", "l": "acetoacetate + ATP + CoA <=> acetoacetyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.90", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74100", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP + H(+) + L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83650", "l": "FasL:Fas binds FADD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64479", "l": "4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate <=> 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799761", "l": "TP53 binds PPP1R13L (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008822", "l": "PPM1D dephosphorylates RUNX2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465921", "l": "11cRDH oxidises 11cROL to 11cRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74190", "l": "S-adenosyl-L-methionine + taxifolin <=> H(+) + S-adenosyl-L-homocysteine + taxifolin 3'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13880", "l": "a 2-oxocarboxylate + L-ornithine <=> an L-alpha-amino acid + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65316", "l": "2-oxoglutarate + chrodrimanin H + O2 = chrodrimanin E + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75694", "l": "2'-deoxyadenosine(in) <=> 2'-deoxyadenosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043185", "l": "vascular endothelial growth factor receptor 3 binding", "d": ["Binding to a vascular endothelial growth factor receptor 3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179413", "l": "Activated PKC-alpha  activate MMP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32230", "l": "(6R)-NADPHX <=> (6S)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64564", "l": "8-epi-ilicicolin H = ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57021", "l": "apulose + ATP => ADP + apulose 4-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26438", "l": "3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.298", "l": "\"3-hydroxypropionate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58694", "l": "FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal => FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008281", "l": "sulfonylurea receptor activity", "d": ["Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56047", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38503", "l": "1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74496", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B => yaequinolone C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44228", "l": "9-decenoate + ATP + CoA = 9-decenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21846", "l": "CoA + H(+) + N(2)-phenylacetyl-L-glutamine => L-glutamine + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66269", "l": "CoA + nonanoyl-AMP => AMP + H(+) + nonanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59337", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene + A => AH2 + demethylspheroidene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69381", "l": "2-hydroxy-4-methylpentanoate + O2 => 4-methyl-2-oxopentanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373730", "l": "Neurofascin and NrCAM heterodimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670014", "l": "Factor VIIIa dissociates  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13406", "l": "4-coumaroyl-CoA + agmatine => CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047670", "l": "anhydrotetracycline monooxygenase activity", "d": ["Catalysis of the reaction: anhydrotetracycline + H+ + NADPH + O2 = 12-dehydrotetracycline + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102511", "l": "pelargonidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> pelargonidin 3,7-di-O-beta-D-glucoside + vanillate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168885", "l": "Haptoglobin binds Hemoglobin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19791", "l": "4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH => 4-(dimethylamino)azobenzene + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044318", "l": "L-aspartate:fumarate oxidoreductase activity", "d": ["Catalysis of the reaction: L-aspartate + fumarate = alpha-iminosuccinate + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27651", "l": "GTP + uridine => GDP + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106290", "l": "trans-cinnamate-CoA ligase activity", "d": ["Catalysis of the reaction: (E)-cinnamate + ATP + CoA = (E)-cinnamoyl-CoA + AMP + diphosphate."]}, {"i": "RHEA:64788", "l": "(E)-cinnamate + ATP + CoA = (E)-cinnamoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43773", "l": "guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70596", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57346", "l": "3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine => 3-hydroxy-D-kynurenine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445067", "l": "NrCAM binds axonin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31505", "l": "4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate => beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40722", "l": "an R-cob(III)alamin + apo-[alkylcobalamin reductase] + glutathione <=> an S-substituted glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21296", "l": "D-galactose + NAD(+) = D-galactono-1,4-lactone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.48", "l": "\"D-galactose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877391", "l": "FOXP3 in complex with RUNX1 binds intron 1 of the IL2RA (CD25) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69162", "l": "H2O2 + N-amidino-(2R)-hydroxypyrrolidine + NH4(+) => agmatine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000156", "l": "phosphorelay response regulator activity", "d": ["Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9006850", "l": "IL21 receptor JAK phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27967", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O => 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67801", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + L-lysyl(27)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390597", "l": "Release Of ADP From Myosin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "50.142754421654764", "identifiers": [{"i": "GO:0005244", "l": "voltage-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448963", "l": "Interaction of MyoD:E protein with MEF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31533", "l": "CO2 + N(omega)-hydroxy-L-arginine + succinate => 2-oxoglutarate + L-arginine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161293", "l": "Tropoelastin forms aggregate globules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58657", "l": "a 5'-end (5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine => a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3785711", "l": "Telomere shortening during replicative exhaustion (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58249", "l": "5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O => ADP-D-ribose + H(+) + L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51634", "l": "all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29097", "l": "4 H(+)(out) + NAD(+) + ubiquinol-8 => 5 H(+)(in) + NADH + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57703", "l": "a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44328", "l": "1-octanoylglycerol + H2O = glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69971", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22S)-22-hydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16431", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451856", "l": "FT is phosphorylated by DCO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20124", "l": "ATP + L-glutamine + tRNA(Gln) <=> AMP + diphosphate + L-glutaminyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211948", "l": "CYP3A4 can N-demethylate loperamide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2737728", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090541", "l": "MIT domain binding", "d": ["Binding to a MIT protein domain. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63806", "l": "GDP-beta-L-galactose => GDP-beta-L-gulose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0046983", "l": "protein dimerization activity", "d": ["The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201515", "l": "Active ALK recruits PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76046", "l": "(S)-cis-N-methyltetrahydropalmatine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + muramine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18895", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP => a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42316", "l": "a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.2.7.11", "l": "\"2-oxoacid oxidoreductase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197770", "l": "STAB1 (FEEL-1) binds ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373738", "l": "Neurofascin interacts with syntenin-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014433", "l": "RHOG GEFs activate RHOG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73797", "l": "FAICAR => IMP + H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68222", "l": "(7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA => (7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36152", "l": "(E)-cinnamyl alcohol + acetyl-CoA => (E)-cinnamyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51200", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine = H2O + N-retinylidene-N-retinylphosphatidylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.14", "l": "\"N-acetylglucosamine-6-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67373", "l": "H2O + L-seryl-L-threonine => L-serine + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507875", "l": "Aquaporins passively transport urea into cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15871", "l": "D-glutamate + pyruvate => 2-oxoglutarate + D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32929", "l": "a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28198", "l": "(S)-1-phenylethanol + NAD(+) = acetophenone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.311", "l": "\"(S)-1-phenylethanol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21706", "l": "NH4(+) + phenol + pyruvate => H2O + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.39", "l": "\"malate dehydrogenase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63889", "l": "hexadecanoyl-CoA + sphinga-4E,14Z-dienine => CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56445", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62997", "l": "(8Z,11Z,14Z)-eicosatrienamide + H2O => (8Z,11Z,14Z)-eicosatrienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62433", "l": "a uridine in tRNA + S-adenosyl-L-methionine => a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23619", "l": "1,2-dihydro-alpha-santonin + NADP(+) <=> alpha-santonin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009541", "l": "ESR1 binds to TFF1 gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011748", "l": "IL9R binds JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41961", "l": "ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GA1 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38030", "l": "(E)-caffeate + hydrocaffeoyl-CoA <=> (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029471", "l": "Hydrolysis of PC to PA by PLD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050698", "l": "proteoglycan sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67203", "l": "H2O + N-acetyltyramine <=> acetate + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72847", "l": "adenosine 3',5'-bisphosphate(in) + ADP(out) = adenosine 3',5'-bisphosphate(out) + ADP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684008", "l": "NBN binds KPNA2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933292", "l": "LSR trimer binds VLDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51930", "l": "(S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH => H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22524", "l": "2 A + a carotenoid beta-end derivative = a carotenoid phi-end derivative + 2 AH2", "d": []}, {"i": "EC:1.3.99.39", "l": "\"carotenoid phi-ring synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72078", "l": "ATP + gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine <=> ADP + H(+) + ophthalmate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909738", "l": "SHP1 and SHP2 bind the common beta chain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72074", "l": "L-histidyl-[protein] + NAD(+) <=> H(+) + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951727", "l": "cAMP binds PKA tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11238", "l": "propane-1,3-diamine + sym-homospermidine => putrescine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708866", "l": "pro-F2R binds vorapaxar (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621888", "l": "Defective HK1 does not phosphorylate Glc to form G6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34597", "l": "3-dehydro-15-methylhexadecasphinganine + CO2 + CoA => H(+) + isopentadecanoyl-CoA + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10449", "l": "2-oxoglutarate + a flavanone + O2 => a flavone + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25007", "l": "2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase] => L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43283", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198813", "l": "GSTO dimers reduce DeHA to AscH- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709547", "l": "ESTG binds ESR2:chaperone complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74862", "l": "dopamine + formaldehyde <=> H2O + norsalsolinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163688", "l": "Dephosphorylation of pChREBP (Thr 666) by PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73577", "l": "CAD hexamer transforms L-Gln to CAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672980", "l": "Dissociation of RAS:RAF complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40527", "l": "2 a ubiquinol + 4 H(+)(in) + O2(in) = 2 a ubiquinone + 4 H(+)(out) + 2 H2O(in)", "d": []}, {"i": "EC:7.1.1.7", "l": "\"ubiquinol oxidase (electrogenic, proton-motive force generating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098680", "l": "template-free RNA nucleotidyltransferase", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the addition of a terminal nucleotide to an RNA molecule in the absence of a nucleic acid template."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417896", "l": "P2Y6 receptor can bind to UDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38775", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58562", "l": "15alpha-stemmadenine intermediate I + NADPH => 15alpha-stemmadenine intermediate II + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210294", "l": "Interaction of PECAM-1 and SHP-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51985", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390912", "l": "HRH1 binds hist (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15757", "l": "L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36226", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419843", "l": "CALCA(83-119) binds CALCR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42590", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31234", "l": "4-acetamidobutanal + H2O + NAD(+) <=> 4-acetamidobutanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50178", "l": "N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848338", "l": "PNPLA4 hydrolyzes TAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70573", "l": "argininosuccinate <=> fumarate + arginine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46691", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA + A <=> 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70515", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose = 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12920", "l": "3alpha(S)-strictosidine + H2O <=> D-glucose + strictosidine aglycone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9659820", "l": "RB1 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16227", "l": "N-(6-aminohexanoyl)-6-aminohexanoate => 1,8-diazacyclotetradecane-2,9-dione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54665", "l": "(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene => pre-alpha-onocerin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21200", "l": "2-oxoglutarate + L-lysine = (S)-2-amino-6-oxohexanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.36", "l": "\"L-lysine 6-transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55862", "l": "all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57229", "l": "GDP + glyoxal => N(2)-(1-hydroxy-2-oxoethyl)-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29964", "l": "H(+)(in) + inosine(in) => H(+)(out) + inosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66076", "l": "2-oxopentanoate + L-kynurenine = H2O + kynurenate + L-2-aminopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030784", "l": "3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43846", "l": "(3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+) => (3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5483229", "l": "HHAT G287V doesn't palmitoylate Hh-Np (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61779", "l": "rebaudioside D + UDP-alpha-D-glucose <=> H(+) + rebaudioside M + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67846", "l": "an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322427", "l": "Beta-catenin recruits CBP/p300 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47091", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) <=> 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592362", "l": "Activation of proMMP7 by MMP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112703", "l": "PTPN11 is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021609", "l": "ESR-associated SRC autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18624", "l": "2-oxoglutarate + a (2S)-flavan-4-one + O2 <=> a (2R,3R)-dihydroflavonol + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28636", "l": "(2E,6E)-farnesyl diphosphate => (+)-5-epi-aristolochene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22980", "l": "a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41543", "l": "8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66243", "l": "ATP + CoA + IC-asc-C9 <=> AMP + diphosphate + IC-asc-C9-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374696", "l": "Phosphorylation of L1 by p90rsk (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617838", "l": "CDKN1A gene transcription is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67306", "l": "H2O2 + myceliothermophin E => 3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264458", "l": "Proteasome mediated degradation of COP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17847", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH => 5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30042", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 <=> benzene-1,2,4-triol + CO2 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381128", "l": "Translation of ATF4  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033411", "l": "UAA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UAA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203716", "l": "eNOS:Caveolin-1 complex binds to Nostrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445085", "l": "Phosphorylation of VAV2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66262", "l": "AMP + H(+) + IC-asc-C7-CoA => CoA + IC-asc-C7-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40194", "l": "(3R)-hydroxyoctanoyl-CoA + NAD(+) <=> 3-oxooctanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194808", "l": "botF LC cleaves target cell VAMP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17666", "l": "L-lysyl-[protein] + octanoyl-[ACP] => H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112153", "l": "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20210", "l": "ATP + xylitol => ADP + H(+) + xylitol 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52968", "l": "hyocholate + UDP-alpha-D-glucuronate = H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56348", "l": "4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 = 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64320", "l": "(9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)-hexadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-996755", "l": "ZFPM proteins bind GATA proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50617", "l": "NADP(+) + nonan-2-one => (3E)-nonen-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35654", "l": "(4R)-hydroxysphinganine + a fatty acyl-CoA <=> an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157937", "l": "NICD3 traffics to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.685364931984026", "identifiers": [{"i": "GO:0019213", "l": "deacetylase activity", "d": ["Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule."]}, {"i": "REACT:R-HSA-5689000", "l": "AADAC deacetylates PHEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0008106", "l": "alcohol dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172183", "l": "Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873917", "l": "Translocation of STAT1 dimer to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034575", "l": "4-isopropylaniline dehydrogenase activity", "d": ["Catalysis of the reaction: 4-isopropylaniline + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174367", "l": "GCL ligates L-Glu to L-Cys (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72141", "l": "estrone 3-sulfate(out) + H(+)(in) => estrone 3-sulfate(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19543", "l": "H(+) + L-glutamyl 5-phosphate + NADPH => L-glutamate 5-semialdehyde + NADP(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948027", "l": "RNASEs bind bacterial phospholipids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42743", "l": "guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38662", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13100", "l": "a (3R)-hydroxyacyl-[ACP] <=> a (2E)-enoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21602", "l": "CoA + N-benzoylanthranilate => anthranilate + benzoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45065", "l": "H2O + N-hexadecanoylethanolamine => ethanolamine + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29030", "l": "2 H(+)(in) + L-glutamate(in) <=> 2 H(+)(out) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047337", "l": "dolichyl-diphosphate-polyphosphate phosphotransferase activity", "d": ["Catalysis of the reaction: dolichyl diphosphate + long-chain-polyphosphate = dolichol-phosphate + long-chain-polyphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.170", "l": "\"3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20208", "l": "methylazoxymethanol + UDP-alpha-D-glucose <=> cycasin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380311", "l": "Recruitment of Plk1 to centrosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033509", "l": "USP9X binds Ub:PEX5L (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427570", "l": "Group 3 - Selective Cl- transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23490", "l": "hydroquinone + NADP(+) => 1,4-benzoquinone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48021", "l": "globoside Gb3Cer + H2O => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391913", "l": "FPR2 binds FPR2 ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034811", "l": "benzo(a)pyrene 9,10-dioxygenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-9,10-dihydrodiol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16300", "l": "5alpha-androstane-3beta,17beta-diol + NADP(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15178", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O => a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874079", "l": "PTK2 binds activated MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507719", "l": "p62:MEKK3 binds to TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10114", "l": "H2O + L,L-cystathionine => L-homocysteine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176318", "l": "Loading of claspin onto DNA during replication origin firing (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19292", "l": "H2O + sucrose 6(F)-phosphate <=> phosphate + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444433", "l": "Cho transports from the extracellular space to the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61692", "l": "holo-[peptidyl-carrier protein] + L-threonyl-5'-AMP = AMP + L-threonyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445071", "l": "Reinsertion of L1 into the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73958", "l": "3,4-dihydroxystyrene + H(+) + NADH <=> 4-ethylcatechol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67516", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705461", "l": "p-Y-STAT1,3,5 dimer binds SOCS1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052919", "l": "aliphatic (R)-hydroxynitrile lyase activity", "d": ["Catalysis of the reaction: an aliphatic (R)-hydroxynitrile = an aliphatic aldehyde or ketone + hydrogen cyanide."]}, {"i": "RHEA:28170", "l": "(2R)-2-hydroxy-2-methylbutanenitrile = butan-2-one + hydrogen cyanide", "d": []}, {"i": "EC:4.1.2.46", "l": "\"aliphatic (R)-hydroxynitrile lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800870", "l": "NDUF subunits bind to form the FP subcomplex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51923", "l": "a quinone + AH2 <=> A + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869694", "l": "oxPL binds CD14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9762246", "l": "ANGPTL4 binds CDH11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75556", "l": "(-)-cyatha-3,12-diene + O2 + reduced [NADPH--hemoprotein reductase] => erinacol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851298", "l": "GPR143 binds L-Dopa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21499", "l": "dimethylallyl diphosphate + H2O <=> diphosphate + prenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35138", "l": "L-alanyl-L-glutamate(out) <=> L-alanyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46017", "l": "(20R)-20-hydroxypregn-4-en-3-one + NAD(+) => H(+) + NADH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605717", "l": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936380", "l": "Interaction of PIN1 with p-IRF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39056", "l": "22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10265", "l": "alpha-D-glucose => beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625828", "l": "FOXO1 binds RETN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683925", "l": "ULK1 is dephosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11277", "l": "4 hydroquinone + O2 => 4 benzosemiquinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66967", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose <=> alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653249", "l": "Cleavage of factor XII variant by activated thrombin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851888", "l": "MET binds SHC1-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24394", "l": "dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate => dTDP-L-dihydrostreptose + streptidine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35758", "l": "NAD(+) + UDP-alpha-D-glucose <=> H(+) + NADH + UDP-3-oxo-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912505", "l": "Synapsis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9681616", "l": "AP2 binds chlorpromazine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247836", "l": "Retromer recycles WLS to the Golgi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.81", "l": "\"(+)-pulegone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033797", "l": "selenate reductase activity", "d": ["Catalysis of the reaction: 2 e(-) + 2 H+ + selenate = H2O + selenite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103046", "l": "alanylglutamate dipeptidase activity", "d": ["Catalysis of the reaction: L-alanyl-L-glutamate + H2O <=> L-alanine + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664273", "l": "SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56317", "l": "3-amino-4-hydroxybenzoate + acetyl-CoA => 3-acetylamino-4-hydroxybenzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40707", "l": "(9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73772", "l": "O2 + preechinulin + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + neoechinulin A + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354077", "l": "Integrin alphaIIb beta3 activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392263", "l": "AVP(20-28) binds AVPR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629918", "l": "NEIL1 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0015378", "l": "sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856945", "l": "PP2A methylation by LCMT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72386", "l": "Na(+)(out) + urate(in) <=> Na(+)(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36973", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-allose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061657", "l": "UFM1 conjugating enzyme activity", "d": ["Isoenergetic transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y = Y-UFM1 + X, where both the X-UFM1 and Y-UFM1 linkages are thioester bonds between the C-terminal amino acid of UFM1 and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63765", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52230", "l": "3 A + biliverdin beta + CO + Fe(2+) + 3 H2O => 3 AH2 + 2 H(+) + heme b + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17402", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => 4-carboxy-2-hydroxy-cis,cis-muconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050623", "l": "berberine reductase activity", "d": ["Catalysis of the reaction: (R)-canadine + 2 NADP+ = berberine + H+ + 2 NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34628", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017095", "l": "heparan sulfate 6-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate."]}, {"i": "REACT:R-HSA-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31444", "l": "ATP + D-sedoheptulose 7-phosphate => ADP + D-sedoheptulose 1,7-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43990", "l": "(2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+) => (2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73856", "l": "5alpha,6beta,17alpha,27-tetrahydroxywithanolide + UDP-alpha-D-glucose => 5alpha,6beta,17alpha-trihydroxywithanolide 27-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53604", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51565", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11841", "l": "benzaldehyde + H2O + NAD(+) => benzoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46241", "l": "a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53910", "l": "CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein] => (2E)-butenoyl-CoA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336182", "l": "GPR37 binds prosaptide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3777129", "l": "HDAC3 containing complexes deacetylate histone (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.42", "l": "\"(4S)-4-hydroxy-2-oxoglutarate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12144", "l": "cyanidin 3-O-rutinoside + UDP-alpha-D-glucose = cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68926", "l": "AMP + diphosphate + hexanal + NADP(+) => ATP + H(+) + hexanoate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102070", "l": "18-hydroxyoleate peroxygenase activity", "d": ["Catalysis of the reaction: 18-hydroxyoleate + a lipid hydroperoxide <=> 9,10-epoxy-18-hydroxystearate + a lipid alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675431", "l": "PP2A dephosphorylates RAF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3095889", "l": "MMACHC dealkylates RCbl (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30839", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-talose = UDP-N-acetyl-beta-L-fucosamine", "d": []}, {"i": "EC:5.1.3.28", "l": "\"UDP-N-acetyl-L-fucosamine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12422", "l": "ADP + D-tagatofuranose 1,6-bisphosphate + H(+) => ATP + D-tagatofuranose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.275", "l": "\"gibberellin A9 O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45298", "l": "a sphingoid base + H(+) + phosphocholine => a sphingosylphosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55136", "l": "ATP + D-alanine + H(+) = D-alanyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416562", "l": "p190RhoGAP binds Plexin-B1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322422", "l": "Beta-catenin recruits SMARCA4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174097", "l": "Association of Emi1 with Cdh1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49338", "l": "H2O + spheroiden-2-one => 2,2-dihydroxyspheroidene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51311", "l": "H(+) + L-methionyl-[F-actin] + NADPH + O2 <=> H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25136", "l": "phosphate + pyridoxamine => H2O + pyridoxamine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59220", "l": "(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)", "d": []}, {"i": "EC:3.7.1.25", "l": "\"2-hydroxy-6-oxohepta-2,4-dienoate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676229", "l": "WIPIs bind PI3P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57355", "l": "O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin <=> H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28528", "l": "(R)-carnitinyl-CoA + crotonobetaine => (R)-carnitine + crotonobetainyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42849", "l": "8-demethyltetracenomycin C + dTDP-beta-L-rhamnose => 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854462", "l": "VLDLR binds VLDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42289", "l": "6-carboxyhexanoyl-[ACP] + H(+) + L-alanine => (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651773", "l": "LIG1 binds POLB at long-patch BER site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186765", "l": "PLC-gamma binds to the active receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51020", "l": "a primary alcohol + 2 Fe(III)-[cytochrome c] = an aldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}, {"i": "EC:1.1.2.8", "l": "\"alcohol dehydrogenase (cytochrome c)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73537", "l": "CDP(in) + UTP(out) => CDP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27295", "l": "D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198314", "l": "DAG stimulates protein kinase C-delta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102358", "l": "daphnetin-8-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 7,8-dihydroxycoumarin <=> S-adenosyl-L-homocysteine + 7-hydroxy-8-methoxycoumarin + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14263", "l": "6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA => (E)-sinapoyl-CoA + D-glucono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55123", "l": "4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902379", "l": "chemoattractant activity involved in axon guidance", "d": ["Any chemoattractant activity that is involved in axon guidance."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102057", "l": "jasmonoyl-valine synthetase activity", "d": ["Catalysis of the reaction: L-valine + ATP(4-) + a jasmonic acid <=> AMP(2-) + diphosphoric acid + a jasmonoyl-valine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66130", "l": "(2S)-2-aminobutanoate + 3-phenylpyruvate => 2-oxobutanoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014812", "l": "ROBOs bind keratan sulfate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33374", "l": "alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] <=> alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74684", "l": "2 AH2 + 2 archaeol + 4 S-adenosyl-L-methionine => 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether + 4 H(+) + 4 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2509831", "l": "ITPA hydrolyses XTP to XMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41957", "l": "2',3'-cyclophospho-CMP + H2O => cytidine 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614271", "l": "Autocleavage of ADGRG6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55041", "l": "(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30289", "l": "9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol => 15-cis-phytoene + 2 a plastoquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0042625", "l": "ATPase-coupled ion transmembrane transporter activity", "d": ["Enables the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40724", "l": "(9E)-octadecenoyl-CoA + H2O => (9E)-octadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102949", "l": "1,2-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: isoorientin + an L-rhamonsylated rhamnosyl acceptor = isoorientin 2'-O-rhamnoside + a non rhamnosylated rhamnosyl acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34656", "l": "C30 botryococcene + 2 S-adenosyl-L-methionine => 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58576", "l": "dihydroprecondylocarpine acetate + NADP(+) = H(+) + NADPH + precondylocarpine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65047", "l": "4-cyanobenzyl alcohol + NAD(+) <=> 4-cyanobenzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42534", "l": "pseudouridine(55) in tRNA => uridine(55) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16917", "l": "2,6-dihydroxypyridine + H(+) + NADH + O2 = 2,3,6-trihydroxypyridine + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.10", "l": "\"2,6-dihydroxypyridine 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32989", "l": "a fatty acid + H(+) + sn-glycero-3-phospho-1D-myo-inositol => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74986", "l": "Elongation of pre-rRNA transcript (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5618331", "l": "HDAC6 deacetylates microtubules (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928578", "l": "EPH receptors autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63423", "l": "2-hydroxyethylphosphonate + CTP <=> cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60150", "l": "(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate => (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54528", "l": "aldehydo-D-ribose 5-phosphate = D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20699", "l": "2 H(+) + 2 superoxide <=> H2O2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32258", "l": "meso-2,6-diaminoheptanedioate + NADP(+) <=> (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043801", "l": "hexulose-6-phosphate synthase activity", "d": ["Catalysis of the reaction: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044024", "l": "histone H2AS1 kinase activity", "d": ["Catalysis of the reaction: histone H2A-serine (position 1) + ATP = histone H2A-phosphoserine (position 1) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 1 of histone H2A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26179", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine <=> 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53945", "l": "2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) => (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28314", "l": "baicalein + UDP-alpha-D-glucuronate = baicalin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3814820", "l": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001602", "l": "pancreatic polypeptide receptor activity", "d": ["Combining with pancreatic polypeptide PP to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15819", "l": "H2O2 + NH4(+) + pyridoxal 5'-phosphate => H2O + O2 + pyridoxamine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428625", "l": "Vesicular inhibitory amino acid transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17323", "l": "2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine => L-tryptophan + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2106614", "l": "Duplex miRNA is loaded into Argonaute (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050561", "l": "glutamate-tRNA(Gln) ligase activity", "d": ["Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + diphosphate + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39175", "l": "(3R)-hydroxyeicosanoyl-CoA = (2E)-eicosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74585", "l": "N-acetyl-L-cysteine + N-terminal L-glutamyl-[protein] => H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375138", "l": "CDO binds BOC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58048", "l": "2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA = 2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45136", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate = 7,8-dihydroneopterin 3'-phosphate + H2O", "d": []}, {"i": "EC:4.2.1.160", "l": "\"2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75810", "l": "Na(+)(out) + propanoate(out) <=> Na(+)(in) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22659", "l": "CDP-ethanolamine + L-serine <=> CMP + H(+) + L-serine-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73607", "l": "CTP(out) + dCTP(in) = CTP(in) + dCTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21163", "l": "acetyl-CoA + ADP + oxaloacetate + phosphate <=> ATP + citrate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961961", "l": "E2F1 binds the CDC25A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57117", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:1901375", "l": "acetate ester transmembrane transporter activity", "d": ["Enables the transfer of an acetate ester from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72549", "l": "2-oxoglutarate(out) + taurocholate(in) => 2-oxoglutarate(in) + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754974", "l": "ADK phosphorylates RBV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37278", "l": "H2O + L-alanyl-L-glutamine <=> L-alanine + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202174", "l": "Activation of ZAP-70 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11698", "l": "H(+) + S-adenosyl-L-homocysteine + staurosporine => 3'-demethylstaurosporine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62577", "l": "ATP + H2O + L-cystine(out) => ADP + H(+) + L-cystine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865320", "l": "CBFB binds RUNX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202328", "l": "Translocation of PKC theta to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68671", "l": "16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58926", "l": "(-)-maackiain + H2O => (3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60032", "l": "8-oxo-GTP + H2O = 8-oxo-GDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30879", "l": "H2O + NAD(+) + prop-2-ynal = 2 H(+) + NADH + propynoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450088", "l": "GLUT1 tetramer binds 4xATP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54920", "l": "13-cis-retinol + NADP(+) = 13-cis-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139895", "l": "tBID activates BAK protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53318", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28897", "l": "cadaverine(out) + L-lysine(in) => cadaverine(in) + L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0106346", "l": "snRNA methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an snRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69653", "l": "2-phenylpropan-2-ol + glutathione disulfide + H2O => cumene hydroperoxide + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928597", "l": "EPH:EFN dimers tetramerise (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59098", "l": "diglucosyl-enterobactin + H(+) + UDP => monoglucosyl-enterobactin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112379", "l": "Recruitment of elongation factors to form elongation complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11023", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19242", "l": "ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] => ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31654", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23516", "l": "(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.31", "l": "\"glycerate 3-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445448", "l": "HHIP binds Hedgehog (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018744", "l": "limonene-1,2-epoxide hydrolase activity", "d": ["Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649856", "l": "Oxidative damage to the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55618", "l": "a carotenoid epsilon-end group => a carotenoid psi-end group", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13084", "l": "biotin amide + H2O <=> biotin + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39392", "l": "(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH => (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014449", "l": "RHOG binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444661", "l": "HCAR2 binds HCAR2 ligands (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20196", "l": "(R)-mevalonate + NADP(+) <=> H(+) + mevaldate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450975", "l": "isocitrate <=> citrate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47898", "l": "6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH => 6-sulfo-D-quinovose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399938", "l": "Activation of Rac1 by FARP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15834", "l": "(S)-4-hydroxymandelate + H(+) + O2 => 4-hydroxybenzaldehyde + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007447", "l": "E2F6 forms the PRC1L4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32243", "l": "alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate", "d": []}, {"i": "EC:5.3.1.29", "l": "\"ribose-1,5-bisphosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14206", "l": "carnosine + S-adenosyl-L-methionine => anserine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607751", "l": "TRAF6 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788999", "l": "HV1-mediated H+ transfer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35170", "l": "minocycline(in) <=> minocycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803978", "l": "S-nitrosylation of cysteine residues in proteins by N2O3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110219", "l": "Cleavage of thymine by TDG glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71910", "l": "GDP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9676255", "l": "Formation of the MLL2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706298", "l": "Active FLT3 binds to CSK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372542", "l": "Loading of dopamine into synaptic veiscles (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33574", "l": "A + methanol <=> AH2 + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785898", "l": "IL4R binds JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54464", "l": "1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47167", "l": "4alpha-carboxyzymosterol + NAD(+) <=> CO2 + NADH + zymosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173542", "l": "SMURF2 ubiquitinates SMAD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60185", "l": "ATP + D-glucose(out) + H2O => ADP + D-glucose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605591", "l": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018665", "l": "4-hydroxyphenylacetate 1-monooxygenase activity", "d": ["Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610726", "l": "The IFT-A complex recruits TULP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13279", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate => [L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391939", "l": "TP receptor can bind thromboxane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51162", "l": "5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.265", "l": "\"3-methylbutanal reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70033", "l": "castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67219", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA <=> (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59405", "l": "L-homoserine => D-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45441", "l": "H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72722", "l": "eIF2 activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71109", "l": "L-leucine(in) + S-methylmercury-L-cysteine(out) => L-leucine(out) + S-methylmercury-L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66986", "l": "CoA + H(+) + isovalerate => 3-methylbutanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043199", "l": "sulfate binding", "d": ["Binding to sulfate, SO4(2-), a negatively charged small molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46165", "l": "a quinone + H(+) + NADPH => a quinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18760", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 <=> CO2 + cylindrospermopsin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110244", "l": "Excision of FapyG by OGG1 glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.19", "l": "\"chondroitin B lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140761", "l": "calmodulin-activated 3',5'-cyclic-AMP phosphodiesterase activity", "d": ["Catalysis of the reactions: nucleoside 3',5'-cyclic AMP + H2O = AMP + H+; this activity is activated by binding to calcium-bound calmodulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734687", "l": "ORC6 is phosphorylated on T195 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31668", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose => dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.7", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015328", "l": "cystine secondary active transmembrane transporter activity", "d": ["Enables the transfer of cystine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17043", "l": "AMP + 2 H(+) + sulfate => adenosine 5'-phosphosulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030612", "l": "arsenate reductase (thioredoxin) activity", "d": ["Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin disulfide is also known as oxidized thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54169", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20248", "l": "ATP + streptomycin <=> 3''-O-adenylylstreptomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42713", "l": "S-adenosyl-L-methionine + uridine(54) in tRNA => 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28553", "l": "acetyl-CoA + anthranilate <=> CoA + N-acetylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210767", "l": "HNF6-dependent synthesis of ONECUT3 protein during early pancreas specification (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626938", "l": "Beta-catenin binds SOX proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209960", "l": "Diiodinated tyrosine can be deiodinated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68591", "l": "(6S)-10-formyltetrahydrofolate + GDP-alpha-D-perosamine <=> (6S)-5,6,7,8-tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28357", "l": "decanoyl-CoA + FAD + H(+) <=> (2E)-decenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033991", "l": "aldos-2-ulose dehydratase activity", "d": ["Catalysis of the reactions: 1,5-anhydro-D-fructose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O; (1a) 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O and (1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23262", "l": "15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848751", "l": "PTK6 binds AKT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12384", "l": "5,6-dihydrouracil + O2 = H2O2 + uracil", "d": []}, {"i": "EC:1.3.3.7", "l": "\"dihydrouracil oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16780", "l": "ATP + H2O + K(+)(out) <=> ADP + H(+) + K(+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32252", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) => (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663127", "l": "p-BMAL1:p-CLOCK,NPAS2 binds F7 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34381", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP => alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42021", "l": "11-dehydrocorticosterone + NAD(+) => H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11868", "l": "D-arabinitol + NADP(+) = D-ribulose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430183", "l": "NCK binds PAK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.32", "l": "\"codeine 3-O-demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690023", "l": "NUBPL binds 4Fe-4S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805426", "l": "CARD8 binds CASP9(1-416) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18746", "l": "2 juglone + O2 => 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47460", "l": "3-oxo-(5Z-tetradecenoyl)-CoA + CoA = (3Z)-dodecenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44165", "l": "ATP + H2O => adenine + D-ribose 5-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65814", "l": "A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA => 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015592", "l": "methylgalactoside transmembrane transporter activity", "d": ["Enables the transfer of methylgalactoside from one side of a membrane to the other. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35187", "l": "(Z)-3-aminoperacrylic acid + AH2 = (Z)-3-aminoacrylate + A + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32978", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75724", "l": "(9Z,12Z)-octadecadienoate + H2O => (10S)-hydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450325", "l": "c-FOS activation by phospho ERK1/2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20143", "l": "2-aminoprop-2-enoate + an S-alkyl sulfenate => an S-alkyl-L-cysteine S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030789", "l": "precorrin-3B C17-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16900", "l": "a 3beta-hydroxysteroid + a triacylglycerol <=> a 3beta-hydroxysteroid ester + a diacylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43348", "l": "cholesteryl (9Z-octadecenoate)(in) = cholesteryl (9Z-octadecenoate)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373746", "l": "SEMA4D interacts with CD45 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9612501", "l": "SGK phosphorylates CREB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74024", "l": "L-alanine(in) + L-serine(out) => L-alanine(out) + L-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25958", "l": "3-dehydroquinate + H(+) + NADH + NH4(+) => 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990275", "l": "preribosome binding", "d": ["Binding to a preribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093332", "l": "p-EPHB phosphorylates SDC2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5336443", "l": "LIN7, CASK and APBA1 bind (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112510", "l": "IL6ST is tyrosine phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75036", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate => 1-hexadecanoyl-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106350", "l": "octaprenyl pyrophosphate synthase activity", "d": ["Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69005", "l": "Cdc6 protein is phosphorylated by CDK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047172", "l": "shikimate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: shikimate + coumaroyl-CoA = 4-coumaroylshikimate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24287", "l": "L-aspartate 4-semialdehyde + NADP(+) + phosphate <=> 4-phospho-L-aspartate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797090", "l": "CCNK binds CDK12 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2245218", "l": "CDK1 phosphorylates PHF8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0043998", "l": "histone H2A acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine = CoA + histone H2A N6-acetyl-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912388", "l": "NICD1 displaces co-repressor complex from RBPJ (CSL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390929", "l": "HTR1 and 5A receptors can bind serotonin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038658", "l": "RHD gene produces PALM-C-Rhesus D protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12569", "l": "4-nitrophenol + H(+) + NADH + O2 => 4-nitrocatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733960", "l": "Bile salts and acids dissociate from ALB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018726", "l": "9-phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: 9-phenanthrol + X-SO3(-) = HX + 9-phenanthrylsulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791180", "l": "Expression of IGFBP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16676", "l": "3-phosphonopyruvate + H2O <=> H(+) + phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420883", "l": "Opsins act as GEFs for G alpha-t (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61390", "l": "ADP + biotin(out) + H(+) + phosphate => ATP + biotin(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61255", "l": "H2O + L-valine + O2 <=> 3-methyl-2-oxobutanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53636", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848864", "l": "PTK6 binds ARAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606561", "l": "MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604368", "l": "Autocatalytic activation of bound proMMP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264865", "l": "Caspase-mediated cleavage of Lamin A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17261", "l": "an aryl sulfate + H2O = a phenol + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.1", "l": "\"arylsulfatase (type I)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944225", "l": "Association of procollagen type XVII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0031753", "l": "endothelial differentiation G protein-coupled receptor binding", "d": ["Binding to an endothelial differentiation G protein-coupled receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60349", "l": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033952", "l": "iota-carrageenase activity", "d": ["Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67797", "l": "a ribonucleotidyl-ribonucleotide-RNA => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654514", "l": "KAL1 binds FGFR1c (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784189", "l": "JAKs bind LIFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32998", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25115", "l": "H2O + pyridoxine 5'-phosphate <=> phosphate + pyridoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56870", "l": "(2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA => (2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58097", "l": "1-tetracosanoylglycerol + H2O => glycerol + H(+) + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.18", "l": "\"glutathione transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25171", "l": "6-hydroxyhexan-6-olide <=> 6-oxohexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48376", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803230", "l": "Dissociation of moderate activity BRAF complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36922", "l": "(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008937", "l": "ferredoxin-NAD(P) reductase activity", "d": ["Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56373", "l": "3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 => 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34453", "l": "dTDP-beta-L-rhamnose => dTDP-6-deoxy-beta-L-talose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769401", "l": "DKK and KRM bind LRP5/6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47571", "l": "ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GD1b (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70717", "l": "glycine(out) => glycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174438", "l": "Formation of the Flap Intermediate on the C-strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18382", "l": "dihydroxyacetone + phosphoenolpyruvate => dihydroxyacetone phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454843", "l": "E-cadherin degradation by MMP3, MMP7 and plasmin. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870466", "l": "RGGT:CHM binds RABs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50331", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052625", "l": "4-aminobenzoate amino acid synthetase activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + ATP + amino acid = 4-aminobenzoyl amino acid conjugate + AMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102915", "l": "piperitol synthase activity", "d": ["Catalysis of the reaction: H+ + (+)-pinoresinol + NADPH + O2 <=> (+)-piperitol + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63967", "l": "sphinga-4E,14Z-dienine-1-phosphate <=> (2E,12Z)-hexadecadienal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14640", "l": "3'-phosphoadenylyl sulfate + a thiol <=> adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49361", "l": "2',2'-dihydroxy-2-oxospirilloxanthin => 2,2'-dioxospirilloxanthin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46297", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40256", "l": "(2E)-hexadecenedioyl-CoA + H2O => (3R)-hydroxyhexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17164", "l": "2,6-dioxo-6-phenylhexa-3-enoate + H2O <=> 2-oxopent-4-enoate + benzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69140", "l": "RPA binds to the Flap (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33659", "l": "H(+) + N-tetracosanoylsphinganine + NADPH + O2 = H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392263", "l": "AVP(20-28) binds AVPR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651697", "l": "Defective SLC34A2 does not cotransport Pi, 3Na+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389354", "l": "Activation of Vav1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420206", "l": "Phosphorylation of SRC-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14952", "l": "A + H2O + quinoline-4-carboxylate <=> 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66249", "l": "CoA + IC-asc-C9-AMP => AMP + H(+) + IC-asc-C9-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54191", "l": "H2O + N-acetyl-L-phenylalanine <=> acetate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44995", "l": "(R)-carnitine + 2-methylbutanoyl-CoA <=> CoA + O-2-methylbutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708457", "l": "HM13 cleaves HMOX1 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47707", "l": "H(+) + iso-precytochalasin + NADPH + O2 <=> cytochalasin Z16 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54504", "l": "all-trans-hexaprenyl diphosphate = beta-hexaprene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14325", "l": "7,8-dihydroxycoumarin + UDP-alpha-D-glucose = daphnin + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.104", "l": "\"o-dihydroxycoumarin 7-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022809", "l": "mobile ion carrier activity", "d": ["Small molecule produced by bacteria that carries an ion across the membrane by enclosing the ion and travelling with the ion across the membrane. It does not form a fully open pore across the membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728150", "l": "SLC5A2 binds gliflozins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22794", "l": "nocardicin A => isonocardicin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9656893", "l": "OPN1MW binds 11cRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111962", "l": "PDE4A,C,D hydrolyse cAMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31274", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 <=> CO2 + H2O + NAD(+) + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614544", "l": "Sulfite is oxidized to sulfate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855077", "l": "Ficolin-3 binds to molecular patterns on the target cell surface  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42623", "l": "(Z)-2-methylureidoacrylate + H(+) + H2O <=> (Z)-2-methylaminoacrylate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050251", "l": "retinol isomerase activity", "d": ["Catalysis of the reaction: all-trans-retinol = 11-cis-retinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68205", "l": "1,2-dihexanoylglycerol + octadecanoyl-CoA => 1,2-dihexanoyl-3-octadecanoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25290", "l": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36367", "l": "(S)-alpha-hydroxyglutarate-gamma-lactone + H2O = 2-hydroxyglutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74252", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.24", "l": "\"ribonuclease T1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140562", "l": "EGF-domain serine xylosyltransferase activity", "d": ["Catalyses the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665705", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853429", "l": "PHLDA1 binds AURKA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165027", "l": "Rev molecules assemble onto the RRE RNA sequence through their ARM sequence (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2485180", "l": "MII catalyses GDP/GTP exchange on Gt (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29672", "l": "Ca(2+)(in) => Ca(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814764", "l": "Plasma membrane resorption (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.093101469280398", "identifiers": [{"i": "GO:0016639", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP."]}, {"i": "EC:1.4.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54502", "l": "beta-geranylfarnesene + diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46455", "l": "2 L-leucyl-tRNA(Leu) <=> cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67217", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA => (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9702849", "l": "CALCR binds gepants (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102963", "l": "(S)-corytuberine synthase activity", "d": ["Catalysis of the reaction: H+ + (S)-reticulinium(1+) + NADPH + O2 <=> (S)-corytuberine + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26102", "l": "(2R)-homocitrate => cis-homoaconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70951", "l": "D-serine + H2O + O2 = 3-hydroxypyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935864", "l": "miR-302b binds RUNX1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39979", "l": "(+-)-pavine + S-adenosyl-L-methionine = H(+) + N-methylpavine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.300", "l": "\"pavine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63352", "l": "2 H(+) + O2 + octadecanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z)-octadecenoyl-CoA + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44805", "l": "1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) => 2-demethylmenaquinol-9 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561072", "l": "OCT3 mediates renal uptake of organic cations (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69068", "l": "RFC dissociates after sliding clamp formation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24255", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate <=> 2 ADP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473584", "l": "Collagen type III degradation by MMP15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14969", "l": "S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.144", "l": "\"trans-aconitate 2-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2509831", "l": "ITPA hydrolyses XTP to XMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38004", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate => 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48998", "l": "2-hydroxy-6-oxo-2,4-heptadienoate + H(+) => 3-methylcatechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450494", "l": "HuR binds mRNAs in the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49572", "l": "Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)", "d": []}, {"i": "EC:4.99.1.9", "l": "\"coproporphyrin ferrochelatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46853", "l": "5alpha-cholest-8-en-3-one + H(+) + NADPH => 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32705", "l": "8-hydroxycopalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21274", "l": "ADP + glutathionylspermidine + H(+) + phosphate => ATP + glutathione + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75373", "l": "guanosine(out) => guanosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-184269", "l": "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37153", "l": "1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140682", "l": "FAD-dependent H3K4me/H3K4me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28393", "l": "N(6)-(D-psicosyl)-L-lysine <=> N(6)-(D-fructosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404142", "l": "atROL binds RBP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392195", "l": "Gi activation by P2Y purinoceptor 12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042615", "l": "CD154 receptor binding", "d": ["Binding to CD154, a receptor found on the surface of some activated lymphocytes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49850", "l": "(-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+) => (-)-dehydrodiconiferyl acid ketone + a quinone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13108", "l": "glycerol 2-phosphate + H2O <=> glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22088", "l": "ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate", "d": []}, {"i": "EC:2.7.6.5", "l": "\"GTP diphosphokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17941", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O", "d": []}, {"i": "EC:4.2.1.99", "l": "\"2-methylisocitrate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296127", "l": "Activation of voltage gated Potassium channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52925", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-418553", "l": "cAMP degradation by Phosphodiesterases (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606839", "l": "Steryl sulfatase hydrolyses sulfate from steroid sulfates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33508", "l": "sphing-4-enine 1-phosphate => (2E)-hexadecenal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672969", "l": "Phosphorylation of RAF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868236", "l": "BAR domain proteins recruit dynamin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15809", "l": "(2E)-geranyl diphosphate + H2O = (R)-linalool + diphosphate", "d": []}, {"i": "EC:4.2.3.26", "l": "\"R-linalool synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73741", "l": "dopamine(out) + 2 H(+)(in) => dopamine(in) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849428", "l": "PTPN1 binds PTK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9669854", "l": "KIT binds type II TKIs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33847", "l": "H2O + N-tetracosanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27711", "l": "ATP + guanosine => ADP + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71044", "l": "L-alanine(in) + L-phenylalanine(out) => L-alanine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23362", "l": "alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP => L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1268025", "l": "SAM50 complex inserts proteins into mitochondrial outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70291", "l": "3-(2-aminophenyl)-3-oxopropanal = H2O + quinolin-4-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706287", "l": "Active FLT3 binds to ABL2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65011", "l": "ATP + decanoate + H(+) <=> decanoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43332", "l": "adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42883", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermine <=> H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004687", "l": "myosin light chain kinase activity", "d": ["Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878054", "l": "HIPK2 phosphorylates RUNX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0004985", "l": "G protein-coupled opioid receptor activity", "d": ["Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22060", "l": "(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:2.8.1.6", "l": "\"biotin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008977", "l": "prephenate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: NAD+ + prephenate = (4-hydroxyphenyl)pyruvate + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23429", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873929", "l": "Casein kinase II phosphorylates STARD10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800315", "l": "MST1 binds MST1R (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017125", "l": "deoxycytidyl transferase activity", "d": ["Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA."]}, {"i": "REACT:R-HSA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37070", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981657", "l": "IL34 dimer binds PTPRZ1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856189", "l": "TNFSF8 binds TNFRSF8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015138", "l": "fumarate transmembrane transporter activity", "d": ["Enables the transfer of fumarate from one side of a membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086088", "l": "voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49317", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75141", "l": "asukamycin + H2O + NAD(+) => 4-hydroxyprotoasukamycin + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201630", "l": "Caspase-mediated cleavage of Acinus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63376", "l": "an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9737780", "l": "MTTP binds lomitapide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30469", "l": "(+)-endo-beta-bergamotene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10450", "l": "a flavone + CO2 + H2O + succinate => 2-oxoglutarate + a flavanone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047346", "l": "aldose-1-phosphate adenylyltransferase activity", "d": ["Catalysis of the reaction: aldose 1-phosphate + ADP = phosphate + ADP-aldose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388503", "l": "Oxytocin receptor bind oxytocin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56691", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 <=> (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418456", "l": "cGMP is degraded by PDEs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008815", "l": "citrate (pro-3S)-lyase activity", "d": ["Catalysis of the reaction: citrate = acetate + oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-874087", "l": "SGT1 binds HSP90 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49393", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390912", "l": "HRH1 binds hist (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31628", "l": "10-deoxymethynolide + dTDP-alpha-D-desosamine => 10-deoxymethymycin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805470", "l": "AMPK phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400143", "l": "Fatty acid ligands activate PPARA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75856", "l": "Abortive Initiation Before Second Transition (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806831", "l": "CYB5Rs reduce MetHb to HbA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41851", "l": "(2E)-octenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33116", "l": "malonate(in) => malonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54538", "l": "a very long-chain fatty acyl-CoA + AMP + diphosphate => a very long-chain fatty acid + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411372", "l": "TCF/LEF:CTNNB1 promote transcription of AXIN2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.72", "l": "\"xylan 1,3-beta-xylosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61914", "l": "ADP + H(+) + phosphate + voriconazole(out) => ATP + H2O + voriconazole(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68563", "l": "arsenate + D-glyceraldehyde 3-phosphate + NAD(+) <=> 1-arsono-3-phospho-D-glycerate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0016848", "l": "carbon-halide lyase activity", "d": ["Catalysis of the breakage of a bond between carbon and any halogen atom."]}, {"i": "EC:4.5.-.-", "l": "\"Carbon-halide lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635841", "l": "GLI proteins are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24085", "l": "all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.42903515889401", "identifiers": [{"i": "GO:0015154", "l": "disaccharide transmembrane transporter activity", "d": ["Enables the transfer of disaccharide from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012542", "l": "IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983061", "l": "TSLP binds CRLF2:IL7R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34525", "l": "[alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP => [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19679", "l": "(3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin => 9'-cis-neoxanthin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56073", "l": "a 2-acylphloroglucinol + UDP-alpha-D-glucose => a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47257", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11442", "l": "2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+) => 2,3,5,6-tetrachlorophenol + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981713", "l": "C4b binds to cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56180", "l": "8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047192", "l": "1-alkylglycerophosphocholine O-acetyltransferase activity", "d": ["Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18293", "l": "ATP + CoA + oxalate = AMP + diphosphate + oxalyl-CoA", "d": []}, {"i": "EC:6.2.1.8", "l": "\"oxalate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41364", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18365", "l": "(R)-malate + NAD(+) = CO2 + NADH + pyruvate", "d": []}, {"i": "EC:1.1.1.83", "l": "\"D-malate dehydrogenase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351936", "l": "Caspase-mediated cleavage of claspin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625416", "l": "Anterograde IFT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40530", "l": "2 a ubiquinol + 4 H(+)(in) + O2(in) <=> 2 a ubiquinone + 4 H(+)(out) + 2 H2O(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70890", "l": "L-glutamine(in) + L-serine(out) + Na(+)(out) <=> L-glutamine(out) + L-serine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047251", "l": "thiohydroximate beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: phenylthioacetohydroximate + UDP-D-glucose = desulfoglucotropeolin + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9681616", "l": "AP2 binds chlorpromazine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11741", "l": "2 glutathione + NADP(+) => glutathione disulfide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66326", "l": "iodide(in) => iodide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24964", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042242", "l": "cobyrinic acid a,c-diamide synthase activity", "d": ["Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23379", "l": "L-threonate + NAD(+) <=> 3-dehydro-D-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10061", "l": "acetyl-CoA + D-tryptophan => CoA + H(+) + N-acetyl-D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15428", "l": "coproporphyrinogen III + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017176", "l": "phosphatidylinositol N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103079", "l": "2-(3'-methylthio)propylmalate synthase activity", "d": ["Catalysis of the reaction: 5-methylthio-2-oxopentanoate + acetyl-CoA + H2O <=> H+ + 2-(3-methylthiopropyl)malate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14178", "l": "(R)-amygdalin + H2O => (R)-prunasin + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868118", "l": "MAPK12 phosphorylates PTPN3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66421", "l": "ATP + glutathione(in) + H2O + tauroursodeoxycholate(in) => ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74733", "l": "Insulin receptor de-phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39504", "l": "(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH => (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75231", "l": "H2O + L-galactono-1,4-lactone = H(+) + L-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029273", "l": "PI3K binds to p-6Y-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5607734", "l": "PKC-delta translocates to plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18615", "l": "4-hydroxybenzoate + A + formaldehyde + H2O => 4-methoxybenzoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004931", "l": "extracellularly ATP-gated monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a monoatomic cation by a channel that opens when ATP is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane."]}, {"i": "REACT:R-HSA-877187", "l": "P2X7 mediates loss of intracellular K+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791121", "l": "Expression of XBP1(S) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31575", "l": "8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+)", "d": []}, {"i": "EC:3.6.1.55", "l": "\"8-oxo-dGTP diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168423", "l": "JAK2 phosphorylation of IRS-1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004818", "l": "glutamate-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47378", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62376", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H2O = (S)-lactate + H(+) + pyruvate", "d": []}, {"i": "EC:3.7.1.26", "l": "\"2,4-didehydro-3-deoxy-L-rhamnonate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53816", "l": "hydrogen sulfide + O-succinyl-L-serine = L-cysteine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24000", "l": "a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58987", "l": "acrolein + H2O + O2 <=> acrylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45609", "l": "H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39826", "l": "eicosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 2-hydroxyeicosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67413", "l": "alpha-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56161", "l": "an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate => an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004060", "l": "arylamine N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419426", "l": "Cannabinoid receptors can bind cannabinoids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19701", "l": "a flavonol 3-O-glycoside + UDP-alpha-D-xylose = a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP", "d": []}, {"i": "EC:2.4.2.35", "l": "\"flavonol-3-O-glycoside xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10998", "l": "2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine => 2-methylpropanal oxime + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614811", "l": "Transcriptional Activation of the HCMV Genome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538824", "l": "PP1 binds to phosphorylated TIM in complex with PER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627089", "l": "CASP9 is phosphorylated at T412 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14966", "l": "an acyl phosphate + H2O => a carboxylate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39953", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685156", "l": "ATR phosphorylates RPA2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008054", "l": "IL1F10 binds IL1RAPL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16132", "l": "NADP(+) + pyridoxine <=> H(+) + NADPH + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013145", "l": "RAC1 binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904067", "l": "ascr#2 binding", "d": ["Binding to ascr#2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53942", "l": "18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40941", "l": "1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+) => 1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54990", "l": "2 H2O(in) => 4 e(-) + 4 H(+)(in) + O2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17339", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+) => catechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41945", "l": "[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9615249", "l": "ARBs bind AGRT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60732", "l": "H2O + NADP(+) + perillyl aldehyde = 2 H(+) + NADPH + perillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787737", "l": "CSF3R binds CSF3 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27759", "l": "(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797245", "l": "Expression of FASLG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166817", "l": "Cleavage of C3 by C3 convertases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42437", "l": "L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] => L-ascorbate 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700120", "l": "PTN and MDK bind to PTPRZ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10172", "l": "(3R)-hydroxybutanoate dimer + H2O = 2 (R)-3-hydroxybutanoate + H(+)", "d": []}, {"i": "EC:3.1.1.22", "l": "\"hydroxybutyrate-dimer hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44812", "l": "1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-11 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033911", "l": "mycodextranase activity", "d": ["Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in alpha-D-glucans containing both 1,3- and 1,4-bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.32", "l": "\"phosphoenolpyruvate carboxykinase (GTP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734343", "l": "Expression of TBX5 in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429157", "l": "ABCC4 accumulation of dense granule contents (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59826", "l": "L-glutamate + pyridoxal 5'-phosphate => 2-oxoglutarate + pyridoxamine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676229", "l": "WIPIs bind PI3P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22374", "l": "3-oxopropanoate + H(+) + H2O2 + nitrite => H2O + O2 + propionate 3-nitronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69918", "l": "guanosine(out) + 2 Na(+)(out) <=> guanosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59151", "l": "ATP + CoA + marinolate C <=> AMP + diphosphate + marinoloyl-CoA C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47068", "l": "4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31572", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 => CO2 + H2O + NADP(+) + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9619376", "l": "CAMK1 binds calmodulin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46852", "l": "5alpha-cholest-8-en-3-one + H(+) + NADPH = 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75211", "l": "Cu(+)(out) = Cu(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031867", "l": "EP4 subtype prostaglandin E2 receptor binding", "d": ["Binding to an EP4 subtype prostaglandin E2 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57726", "l": "CO2 + 2 Na(+)(out) + pyruvate => H(+) + 2 Na(+)(in) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72760", "l": "anthocyanin A6 + malonyl-CoA => anthocyanin A8 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696564", "l": "USP25 deubiquitinates DDX58 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26077", "l": "methanesulfonate + NADH + O2 = formaldehyde + H2O + NAD(+) + sulfite", "d": []}, {"i": "EC:1.14.13.111", "l": "\"methanesulfonate monooxygenase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854408", "l": "APOBR dimer binds VLDLs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.3.6", "l": "\"N-acetyllactosaminide alpha-2,3-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061513", "l": "glucose 6-phosphate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + inorganic phosphate(in) = glucose 6-phosphate(in) + inorganic phosphate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70629", "l": "2''-O-dodecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-dodecanoyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60904", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = 13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033853", "l": "aspartate-prephenate aminotransferase activity", "d": ["Catalysis of the reaction: L-arogenate + oxaloacetate = prephenate + L-aspartate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086410", "l": "CDK1 phosphorylates BORA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156678", "l": "Activation of Cdc25C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47715", "l": "trans-3-hydroxy-L-proline <=> cis-3-hydroxy-D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65480", "l": "2-methylbutanoyl-CoA + hexan-1-ol = CoA + hexyl 2-methylbutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050615", "l": "1,2-dihydrovomilenine reductase activity", "d": ["Catalysis of the reaction: 17-O-acetylnorajmaline + NADP+ = 1,2-dihydrovomilenine + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821412", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72708", "l": "GDP-beta-L-fucose(in) + GMP(out) => GDP-beta-L-fucose(out) + GMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34188", "l": "(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O => (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17606", "l": "ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine => ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218812", "l": "FYN phosphorylates PAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19278", "l": "ATP + L-pyrrolysine + tRNA(Pyl) => AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340226", "l": "CYGB dioxygenates NO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22381", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O => [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937177", "l": "AHR:TCDD binds ARNT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72154", "l": "estrone 3-sulfate(out) + glutarate(in) <=> estrone 3-sulfate(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54349", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0000107", "l": "imidazoleglycerol-phosphate synthase activity", "d": ["Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450741", "l": "VANG, IN, FY, and FRTZ colocalise at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41169", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0042900", "l": "arabinose transmembrane transporter activity", "d": ["Enables the transfer of arabinose, a pentose monosaccharide that occurs in both D and L configurations, and as a polymer, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928646", "l": "EPHAs bind EFNAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18128", "l": "A + a D-alpha-amino acid + H2O <=> a 2-oxocarboxylate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030777", "l": "(S)-scoulerine 9-O-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-scoulerine + S-adenosyl-L-methionine(1+) = (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784765", "l": "p-Y705-STAT3 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17600", "l": "D-mannitol + 2 Fe(III)-[cytochrome c] <=> D-fructose + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73274", "l": "rhamnetin + S-adenosyl-L-methionine <=> H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675921", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51163", "l": "cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71591", "l": "2-oxoglutarate(out) + malonate(in) = 2-oxoglutarate(in) + malonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16474", "l": "cyclohexane-1,3-dione + H2O => 5-oxohexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59882", "l": "3,4-dihydroxyphenylacetate + FMN + H(+) + H2O => 4-hydroxyphenylacetate + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827997", "l": "Expression of NANOG in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417825", "l": "P2Y11 receptor can bind to ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11422", "l": "H2O + NADP(+) + senecionine N-oxide => NADPH + O2 + senecionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22903", "l": "(R)-acetoin + NAD(+) <=> diacetyl + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983421", "l": "Journey of cargo through Golgi complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56519", "l": "Fe-coproporphyrin III + 2 H(+) + 2 H2O2 <=> 2 CO2 + 4 H2O + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2681675", "l": "Syndecan-1 binds THBS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849826", "l": "ST14 hydrolyzes and activates KLK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68341", "l": "(R)-4'-phospho-S-sulfopantetheine + H2O => (R)-S-sulfopantetheine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71221", "l": "2 Na(+)(in) + nitrate(in) => 2 Na(+)(out) + nitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:1901478", "l": "aminotriazole transmembrane transporter activity", "d": ["Enables the transfer of amitrole from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36894", "l": "(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 <=> (9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-184323", "l": "Monoubiquitination of N-myristoyl GAG polyprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25269", "l": "(R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33396", "l": "H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester => GMP + N(alpha)-acetyl-L-lysine methyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49652", "l": "H(+) + NADH + O2 + protoviolaceinate = H2O + NAD(+) + violaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623240", "l": "FOXO1 binds PPARGC1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.118", "l": "\"phospholipid sn-1 acylhydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2399913", "l": "atRAL binds to RBP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46813", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691131", "l": "CANDI binds CUL1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69026", "l": "H2O + N,N-dihydroxy-L-aspartate + NADP(+) => H(+) + N-hydroxy-L-aspartate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47234", "l": "(2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912362", "l": "MIR150 microRNA binds 3'UTR of NOTCH3 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021068", "l": "PalmS-ESRs bind CAVs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40972", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052923", "l": "all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity", "d": ["Catalysis of the reaction: geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9696267", "l": "RND3 binds GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25147", "l": "(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde = H(+) + H2O + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209823", "l": "Tyrosine is hydroxylated to dopa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000310", "l": "AURKA phosphorylates PLK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50700", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26487", "l": "H(+) + O-phospho-L-serine + sulfite => L-cysteate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46372", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73693", "l": "3'-AMP(in) + phosphate(out) => 3'-AMP(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70755", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.60", "l": "\"diadenosine hexaphosphate hydrolase (AMP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35069", "l": "(S)-carnitine(in) => (S)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57364", "l": "H2O + NADH = (6S)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198714", "l": "ERK5 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54896", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate + ATP + CoA = (10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635854", "l": "GLI2,3 are degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32396", "l": "(1S,2S,4S)-dihydrocarveol + NAD(+) => (1S,4S)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865774", "l": "TTLLs polyglutamylate tubulin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204779", "l": "Interaction of Tie2 with Ang1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13677", "l": "D-ribulose 5-phosphate = D-xylulose 5-phosphate", "d": []}, {"i": "EC:5.1.3.1", "l": "\"ribulose-phosphate 3-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50801", "l": "glutathione + prostaglandin A2 => prostaglandin A2-S-(S)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68903", "l": "4-methoxybenzoate + ATP + H(+) + NADPH <=> 4-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74057", "l": "D-cysteine(in) + L-alanine(out) => D-cysteine(out) + L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679045", "l": "C-ter TLR9 dimer binds HCQ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679031", "l": "Defective ABCC2 does not transport BMG,BDG from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47014", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine => [DsrC protein]-disulfide + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429415", "l": "SYK binds to integrin alphaIIb beta3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31177", "l": "(S)-3-hydroxyisobutanoyl-CoA => (2E)-2-methylpropenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28881", "l": "H(+)(out) + L-tryptophan(out) => H(+)(in) + L-tryptophan(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74815", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73271", "l": "rhamnetin + S-adenosyl-L-methionine = H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33560", "l": "an acyl-CoA + sn-glycerol 3-phosphate => a 2-acyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13091", "l": "6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite => 6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46388", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.-", "l": "\"Hydroxymethyl-, formyl- and related transferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982617", "l": "CYGB:O2 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48103", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038062", "l": "protein tyrosine kinase collagen receptor activity", "d": ["Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46750", "l": "carbamate + 2 H(+) + phosphate => carboxyphosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41886", "l": "3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP] => dodecanoyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25904", "l": "futalosine + H2O = dehypoxanthine futalosine + hypoxanthine", "d": []}, {"i": "EC:3.2.2.26", "l": "\"futalosine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26308", "l": "2-aminophenol + O2 <=> 2-aminomuconate 6-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015135", "l": "glucuronate transmembrane transporter activity", "d": ["Enables the transfer of glucuronate from one side of a membrane to the other. Glucuronate is the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042925", "l": "benzoate transmembrane transporter activity", "d": ["Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) from one side of a membrane to the other."]}, {"i": "RHEA:32811", "l": "benzoate(in) = benzoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63178", "l": "(2R)-ibuprofenoyl-CoA => (2S)-ibuprofenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30775", "l": "H2O + O2 + pyridoxamine = H2O2 + NH4(+) + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44005", "l": "3-methyl fatty acid + ATP + CoA => a 3-methyl fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.863640214551324", "identifiers": [{"i": "GO:0046625", "l": "sphingolipid binding", "d": ["Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22155", "l": "a ubiquinone + D-glucose <=> a ubiquinol + D-glucono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16768", "l": "D-mannitol + NADP(+) <=> D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947499", "l": "Exchange of oxygen with sulfur in MoCo (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416562", "l": "p190RhoGAP binds Plexin-B1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162590", "l": "Import of PIC to the Host Nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40502", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31021", "l": "4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O => 4 AH2 + all-trans-4,4'-diapolycopene + 4 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68683", "l": "3'-phosphoadenylyl sulfate + 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(beta-D-glucuronate) <=> 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63475", "l": "all-trans-hexaprenol + ATP <=> ADP + all-trans-hexaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.55", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211924", "l": "CYP4B1 12-hydroxylates ARA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11332", "l": "ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide", "d": []}, {"i": "EC:2.7.7.19", "l": "\"polynucleotide adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37763", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55742", "l": "D-glucose + oleuropein aglycone => H2O + oleuropein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209973", "l": "Tyrosine is diiodinated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37341", "l": "(R)-3-amino-2-methylpropanoate + CO2 + NH4(+) => 3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802908", "l": "RAS mutants bind inactive RAF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030268", "l": "methylenetetrahydromethanopterin dehydrogenase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 + 2 H+ = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29973", "l": "2'-deoxyinosine(out) + H(+)(out) => 2'-deoxyinosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51603", "l": "2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37868", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA => 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43142", "l": "2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine => guanosine(26) in tRNA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876789", "l": "CARNMT1 methylates CARN to Anserine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52491", "l": "O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432010", "l": "Aquaporin-1 passively transports water into cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18193", "l": "H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] = (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034916", "l": "2-methylhexanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-methylhexanoyl-CoA = 2-methylhex-2-enoyl-CoA + 2 H+ + e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666001", "l": "Profilin:G-actin binds MKL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20440", "l": "5D-5-O-methyl-chiro-inositol + NADP(+) <=> 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10678", "l": "2-isopropylmaleate + H2O => (2R,3S)-3-isopropylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59957", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate => a nitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730904", "l": "Auto-ubiquitination of TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016719", "l": "carotene 7,8-desaturase activity", "d": ["Catalysis of the reaction: neurosporene + donor-H2 + O2 = lycopene + acceptor + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110322", "l": "Formation of Pol zeta complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51667", "l": "D-5-phenylhydantoin + H2O <=> H(+) + N-carbamoyl-D-phenylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37549", "l": "3-dehydro-D-glucose 6-phosphate + H(+) + NADH => D-glucose 6-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707594", "l": "Hemes bind LY96 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60778", "l": "CO2 + gibberellin A15 + succinate => 2-oxoglutarate + gibberellin A12 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16642", "l": "a long-chain fatty acyl ethyl ester + H2O => a long-chain fatty acid + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66235", "l": "IC-asc-C7-CoA + O2 <=> H2O2 + IC-asc-DeltaC7-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54695", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (13E)-labda-7,13-dien-15-yl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043861", "l": "agmatine:putrescine antiporter activity", "d": ["Catalysis of the reaction: agmatine(out) + putrescine(in) = agmatine(in) + putrescine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011958", "l": "miR-26A and B bind to the 3'UTR of the GREB1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46438", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin] => (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2106625", "l": "Duplex siRNA is loaded into Argonaute (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46780", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.46", "l": "\"sn-1 linoleoyl-lipid 6-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193665", "l": "MYD88 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693609", "l": "ATM phosphorylates TP53 at S15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20363", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201457", "l": "BMP2 binds to the receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69146", "l": "4-guanidinobutanal + H2O2 + NH4(+) => agmatine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59704", "l": "D-cellohexaono-1,5-lactone + H2O = D-cellohexaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13734", "l": "an n-alkanal + NAD(+) => an alk-2-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9736953", "l": "FURIN translocates to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75729", "l": "(10S)-hydroxy-(12Z)-octadecenoate => (10E,12Z)-octadecadienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42561", "l": "uridine(27/28) in mitochondrial tRNA => pseudouridine(27/28) in mitochondrial tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022828", "l": "phosphorylation-gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel that opens in response to phosphorylation of one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54930", "l": "(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+) => 3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810843", "l": "Envoplakin binds periplakin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18332", "l": "(1S,3R,5S)-sabinol + NAD(+) <=> (1S,5S)-sabinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112510", "l": "IL6ST is tyrosine phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014456", "l": "GDIs block activation of RHOG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77077", "l": "Capping complex formation (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645481", "l": "TIFA oligomerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.73", "l": "\"inosine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64793", "l": "L-lysine + NADP(+) => 2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654792", "l": "Expression of GRB10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17455", "l": "ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate => 5-phospho-beta-D-ribosylamine + ATP + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937814", "l": "RUNX3 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029453", "l": "Phosphorylation of VAV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64540", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": []}, {"i": "EC:2.7.1.228", "l": "\"mannosyl-inositol-phosphoceramide inositolphosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68374", "l": "2-oxosuccinamate + L-alanine => L-asparagine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070908", "l": "tyrosine:tyramine antiporter activity", "d": ["Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64637", "l": "benzoyl-CoA + butan-1-ol => butyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56371", "l": "3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 <=> 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198611", "l": "AKT phosphorylates IKKalpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709547", "l": "ESTG binds ESR2:chaperone complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77608", "l": "Binding of A1CF to stem-looped RNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12430", "l": "benzene-1,2,4-triol + NAD(+) => 2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75962", "l": "(S)-scoulerine + 2-oxoglutarate + O2 <=> (S)-3-O-demethylscoulerine + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51693", "l": "prephenate + S-adenosyl-L-methionine => 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14095", "l": "indole-3-pyruvate + L-glutamate => 2-oxoglutarate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879909", "l": "Activation of STAT5a/b by JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58182", "l": "all-trans-lycopaoctaene + diphosphate + NADP(+) => (1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37788", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75959", "l": "(S)-scoulerine + 2-oxoglutarate + O2 = (S)-3-O-demethylscoulerine + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905948", "l": "ABC-type 3',5'-cyclic GMP transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + 3',5'-cyclic GMP(in) = ADP + phosphate + 3',5'-cyclic GMP(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610730", "l": "GSK3 phosphorylates p-GLI2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74747", "l": "Dephosphorylation of p-Y-IRS1,p-Y-IRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796617", "l": "MIB2 binds CFLAR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58426", "l": "(E)-hex-2-enal + H(+) + NADPH => (E)-hex-2-en-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204169", "l": "PDP dephosphorylates p-lipo-PDH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64385", "l": "H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine => alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797268", "l": "Expression of HMOX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944215", "l": "Association of procollagen type XX (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199910", "l": "MSK1 activates ATF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22247", "l": "kaempferol + UDP-alpha-D-xylose <=> H(+) + kaempferol 3-O-beta-D-xyloside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20529", "l": "2-cis-(+)-abscisic aldehyde + H2O + O2 = 2-cis-(+)-abscisate + H(+) + H2O2", "d": []}, {"i": "EC:1.2.3.14", "l": "\"abscisic-aldehyde oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29338", "l": "H2O + L-alanyl-L-glutamate <=> L-alanine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3095889", "l": "MMACHC dealkylates RCbl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21442", "l": "a long-chain alkane + formate + H2O + 2 NADP(+) => a long-chain fatty aldehyde + H(+) + 2 NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33558", "l": "an N-acyl-(4R)-4-hydroxysphinganine + H2O <=> (4R)-hydroxysphinganine + a fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20302", "l": "ATP + L-arginine + tRNA(Arg) => AMP + diphosphate + L-arginyl-tRNA(Arg)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61126", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin => kaempferol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49098", "l": "3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine => H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31733", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O => 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635846", "l": "GLI proteins bind GLI1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047655", "l": "allyl-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: allyl alcohol + NADP+ = acrolein + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2529020", "l": "CK2 phosphorylates condensin I subunits (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39990", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol <=> all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12079", "l": "an aromatic primary alcohol + NAD(+) <=> an aromatic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212651", "l": "Transport of L-Glutamine (cytosol) to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685953", "l": "SIRT6 deacetylates RBBP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264458", "l": "Proteasome mediated degradation of COP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050526", "l": "poly(3-hydroxybutyrate) depolymerase activity", "d": ["Catalysis of the reaction: H2O + poly[(R)-3-hydroxybutanoate](n) = poly[(R)-3-hydroxybutanoate](x) + poly[(R)-3-hydroxybutanoate](n-x); x is 1-5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174731", "l": "Degradation of newly synthesized ApoB-48 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9732629", "l": "PPARG binds PPARG agonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46721", "l": "(3R)-hydroxyhexanoyl-CoA => (2E)-hexenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102706", "l": "butein:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: butein 4'-beta-D-glucoside + O2 = aureusidin 6-O-beta-glucoside + H2O + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674095", "l": "PDGFRs bind type II TKI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610720", "l": "PKA phosphorylates GLI3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15135", "l": "2-oxoglutarate + H(+) + NADH + NH4(+) => H2O + L-glutamate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791054", "l": "Expression of GSK3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35521", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine => (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72479", "l": "citrate(out) + trans-aconitate(in) = citrate(in) + trans-aconitate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18132", "l": "2-oxoaldehyde + H2O + NADP(+) <=> a 2-oxocarboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004450", "l": "isocitrate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60661", "l": "1,4-benzoquinone + H(+) + NADH => hydroquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72293", "l": "2,3-dimethylsuccinate(in) + 3 Na(+)(in) => 2,3-dimethylsuccinate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29962", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928641", "l": "PAK binds RAC and bPIX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40798", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13895", "l": "ADP + AMP + 2 H(+) => H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9754974", "l": "ADK phosphorylates RBV (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811508", "l": "ING2-bound EP300 acetylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66637", "l": "(2E,6E)-farnesyl diphosphate + H2O => (-)-alpha-acorenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691131", "l": "CANDI binds CUL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-571327", "l": "IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60991", "l": "(E)-hex-2-en-1-ol + NAD(+) <=> (E)-hex-2-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709831", "l": "HSP90 binds TBK1 and IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.4.-", "l": "\"Linked to decarboxylation\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617492", "l": "EGR2 (KROX20) activates HOXB2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63621", "l": "ATP + dodecanoate + holo-[ACP] => AMP + diphosphate + dodecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31458", "l": "NAD(+) + reduced riboflavin <=> 2 H(+) + NADH + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50457", "l": "prostaglandin H3 => prostaglandin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956684", "l": "ITCH polyubiquitinates TP73 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163625", "l": "Glucagon binds to Glucagon receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444859", "l": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730882", "l": "Phosphorylation of PKC-theta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48818", "l": "17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5653957", "l": "Rag dimer formation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74720", "l": "myricetin + S-adenosyl-L-methionine => 7-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.3", "l": "\"plus-end-directed kinesin ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004453", "l": "juvenile-hormone esterase activity", "d": ["Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852716", "l": "Thrombin, ELANE cleave C5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62712", "l": "betaenone C + H(+) + NADPH + O2 = H2O + NADP(+) + stemphyloxin I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56059", "l": "genistein + UDP-alpha-D-glucose <=> genistein 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76098", "l": "(11R)-19-oxocarlactone + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-carlactonoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034931", "l": "1-hydroxypyrene methyltransferase activity", "d": ["Catalysis of the reaction: 1-hydroxypyrene + XCH3 = 1-methoxypyrene + HX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25018", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41188", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58124", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36366", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH <=> (9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682863", "l": "RNF168 binds DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357479", "l": "p-AXL binds PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858346", "l": "AMHR2 binds AMH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53179", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67305", "l": "3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 => H2O2 + myceliothermophin E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45624", "l": "ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine = AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.46", "l": "\"L-allo-isoleucine--holo-[CmaA peptidyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0016248", "l": "channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848110", "l": "SOCS3 binds activated PTK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58102", "l": "(15Z)-tetracosenoate + glycerol + H(+) => 1-(15Z-tetracosenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38972", "l": "O2 + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47984", "l": "H2O + presqualene diphosphate = diphosphate + hydroxysqualene", "d": []}, {"i": "EC:4.2.3.156", "l": "\"hydroxysqualene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380949", "l": "AMPK is dephosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41655", "l": "aclacinomycin S + dTDP-2-deoxy-beta-L-fucose <=> 2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821366", "l": "AKAP8L binds MLL2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953430", "l": "PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.21", "l": "\"chondroitin-sulfate-ABC exolyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696482", "l": "CTF1 binds LIFR:JAKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70359", "l": "3-oxosphinganine + a fatty acyl-CoA = CoA + H(+) + N-acyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.20", "l": "\"succinyl-CoA--D-citramalate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18814", "l": "(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate => (3E,5R)-5-carboxy-2-oxohept-3-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12772", "l": "A + D-gluconate <=> 2-dehydro-D-gluconate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60701", "l": "a 1-acyl-sn-glycero-3-phosphocholine => a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74646", "l": "CMP-N-acetyl-beta-neuraminate(in) + UMP(out) <=> CMP-N-acetyl-beta-neuraminate(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39096", "l": "(3S)-hydroxydecanedioyl-CoA + NAD(+) => 3-oxodecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52105", "l": "a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38151", "l": "carbonyl sulfide + H2O = CO2 + H(+) + hydrogen sulfide", "d": []}, {"i": "EC:3.13.1.7", "l": "\"carbonyl sulfide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37449", "l": "H(+) + H2O + tetracenomycin D3 => O2 + tetracenomycin F1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18377", "l": "ATP + streptomycin = ADP + H(+) + streptomycin 3''-phosphate", "d": []}, {"i": "EC:2.7.1.87", "l": "\"streptomycin 3''-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35971", "l": "12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate = diphosphate + fumitremorgin B", "d": []}, {"i": "EC:2.5.1.110", "l": "\"12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.109", "l": "\"endogalactosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213241", "l": "Formation of nonameric complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11529", "l": "2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72436", "l": "(E)-caffeoyl-AMP + CoA => (E)-caffeoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27323", "l": "6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010645", "l": "AKAP5 recruits PPP3CB (PP2BB) to ROBO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68408", "l": "(2R,3S)-iso(homo)3citrate + NAD(+) = 2-oxosuberate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870466", "l": "RGGT:CHM binds RABs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029460", "l": "PAK1 phosphorylates LIMK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445072", "l": "Interaction of PAK1 with Rac1-GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9650473", "l": "SERPING1 is secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18755", "l": "[protein]-disulfide + H(+) + NADPH => [protein]-dithiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34829", "l": "H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+) => H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45570", "l": "[acharan](n) => [heparosan](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0019707", "l": "protein-cysteine S-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule."]}, {"i": "RHEA:63372", "l": "an acyl-CoA + L-cysteinyl-[protein] = an S-acyl-L-cysteinyl-[protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62743", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) <=> 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59085", "l": "2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose => 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51538", "l": "H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP => L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62317", "l": "salicylate + UDP-alpha-D-glucose => 1-O-salicyl-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68039", "l": "(S)-cystathionine ketimine + 2 H(+) + NADPH <=> (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70300", "l": "H2O + L-dehydroascorbate => 2,3-dioxo-L-gulonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12090", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP => an N-acylsphing-4-enine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482770", "l": "Release of platelet secretory granule components (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015169", "l": "glycerol-3-phosphate transmembrane transporter activity", "d": ["Enables the transfer of glycerol-3-phosphate from one side of a membrane to the other. Glycerol-3-phosphate is a phosphoric monoester of glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19331", "l": "H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP => nuatigenin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601883", "l": "Complexed PIWIL4 binds cleaved transposon RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426209", "l": "DAG activation of TRPC channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396009", "l": "STING binds c-di-GMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70571", "l": "D-glucose(out) + Na(+)(out) = D-glucose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39864", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005462", "l": "UDP-N-acetylglucosamine transmembrane transporter activity", "d": ["Enables the transfer of a UDP-N-acetylglucosamine from one side of a membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008755", "l": "O antigen polymerase activity", "d": ["Catalysis of the polymerization of o-antigen chains. O-antigens are tetra- and pentasaccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55556", "l": "a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63410", "l": "3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O => 6-chloropyridine-2,3,5-triol + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68351", "l": "ATP + GTP <=> diphosphate + pppA(2'-5')pG", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45843", "l": "(3R)-3-hydroxydecanoyl-CoA + NADP(+) <=> 3-oxodecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55082", "l": "ADP + H(+) + sucrose => ADP-alpha-D-glucose + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265443", "l": "NPC1L1-mediated cholesterol uptake (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65166", "l": "CoA + hexan-3-yl benzoate => benzoyl-CoA + hexan-3-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26549", "l": "beta-alaninamide + H2O <=> beta-alanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6795667", "l": "MDM2 translocates to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17777", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}, {"i": "EC:3.1.1.47", "l": "\"1-alkyl-2-acetylglycerophosphocholine esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016505", "l": "peptidase activator activity involved in apoptotic process", "d": ["Binds to and increases the activity of a peptidase that is involved in the apoptotic process."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381537", "l": "PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67772", "l": "a 5'-end 5'-monophospho-ribonucleoside-RNA + H2O = a 5'-end dephospho-ribonucleoside-RNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086084", "l": "cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication", "d": ["Binding to a protein or protein complex that results in the connection of a Purkinje myocyte with an ventricular cardiac muscle cell and contributes to the communication between the two cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24695", "l": "(E)-isoeugenol + acetate + NADP(+) => (E)-coniferyl acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.75", "l": "\"poly(3-hydroxybutyrate) depolymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661432", "l": "BIL binds ALB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50464", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH = 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247844", "l": "WNT ligands traffic to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25878", "l": "H2O2 + iminosuccinate => L-aspartate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408543", "l": "SeCysta is hydrolysed to Sec by PXLP-K212-CTH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373006", "l": "acetyl-CoA + H2O + oxaloacetate => citrate + CoA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16502", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol => H(+) + myo-inositol + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69245", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate => 5-methylsulfinylpentyl nitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51604", "l": "2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] = 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.25", "l": "\"p-cymene methyl-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050034", "l": "L-rhamnose 1-dehydrogenase activity", "d": ["Catalysis of the reaction: L-rhamnofuranose + NAD+ = L-rhamnono-1,4-lactone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5631885", "l": "PRDX1 overoxidizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190519", "l": "Internalization of gap junction plaques (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28823", "l": "H(+)(in) + L-galactonate(in) = H(+)(out) + L-galactonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5618107", "l": "ATP binding to HSP90 triggers conformation change (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017166", "l": "vinculin binding", "d": ["Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015126", "l": "canalicular bile acid transmembrane transporter activity", "d": ["The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102607", "l": "3beta-hydroxy-12,15-cassadiene-11-one 2-hydroxylase activity", "d": ["Catalysis of the reaction: 3beta-hydroxy-12,15-cassadiene-11-one + NADPH + O2 + H+ <=> 2beta,3beta-dihydroxy-12,15-cassadiene-11-one + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42874", "l": "H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine => N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112037", "l": "Inactivation of PLC beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10088", "l": "sucrose + UDP-alpha-D-galactose = 6(F)-alpha-D-galactosylsucrose + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.167", "l": "\"sucrose 6(F)-alpha-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39093", "l": "(3S)-hydroxydecanedioyl-CoA => (2E)-decenedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30577", "l": "3 menaquinol-8 + protoporphyrin IX => 3 menaquinone-8 + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877902", "l": "Activated AR binds RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37929", "l": "8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416516", "l": "GRK2 sequesters activated Gq (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62193", "l": "O2 + peregrinol + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53659", "l": "(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 <=> (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202947", "l": "Caspase mediated cleavage of APC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55107", "l": "3-oxoheptanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyheptanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102507", "l": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (hydroxybenzoly-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> cyanidin 3,7-di-O-beta-D-glucoside betaine + 4-hydroxybenzoic acid + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682709", "l": "LGI4 binds ADAM22,23,11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.98780181426379", "identifiers": [{"i": "GO:0019904", "l": "protein domain specific binding", "d": ["Binding to a specific domain of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20410", "l": "alpha-D-glucose 1-phosphate + riboflavin => D-glucose + FMN", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32514", "l": "(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O <=> (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34240", "l": "L-glutamate => 3-aminopentanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "57.494971907972456", "identifiers": [{"i": "GO:1901363", "l": "heterocyclic compound binding", "d": ["Binding to heterocyclic compound."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798044", "l": "BTG2 binds CCR4-NOT complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10622", "l": "(E)-cinnamoyl-CoA + H(+) + NADPH => (E)-cinnamaldehyde + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616214", "l": "RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64664", "l": "a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37053", "l": "ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => 3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16007", "l": "5-dehydro-4-deoxy-D-glucarate + H2O => galactarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12916", "l": "(R)-lipoate + ATP + H(+) <=> (R)-lipoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46184", "l": "ATP + CoA + isovalerate = 3-methylbutanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.5", "l": "\"apyrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419452", "l": "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34210", "l": "3-O-alpha-D-glucosyl-L-rhamnose + phosphate <=> beta-D-glucose 1-phosphate + L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28065", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57462", "l": "4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP => (E)-sinapyl alcohol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810158", "l": "HOXB3 chromatin is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661726", "l": "An unknown reductase reduces D-UBGN to STBN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51915", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667563", "l": "AVPR2 bind desmopressin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56776", "l": "(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55592", "l": "2 (3R)-hydroxydecanoyl-[ACP] + H2O = (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63421", "l": "2-hydroxyethylphosphonate + CTP => cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25279", "l": "AMP + H(+) => 3',5'-cyclic AMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24807", "l": "2-(1-hydroxyethyl)thiamine diphosphate + pyruvate => (2S)-2-acetolactate + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509838", "l": "ITPA hydrolyses dITP to dIMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602473", "l": "Autocatalytic activation of MMP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682631", "l": "nsp13 binds DDX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981621", "l": "C3 convertases spontaneously dissociate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73495", "l": "an 8-hydroxyflavone + S-adenosyl-L-methionine = an 8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10860", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 = 2-(acetamidomethylene)succinate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450348", "l": "Activated human JNKs migrate to nucleoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873917", "l": "Translocation of STAT1 dimer to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52108", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55220", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}, {"i": "EC:1.14.18.9", "l": "\"4alpha-methylsterol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61101", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70355", "l": "1-carboxybiuret + H(+) = biuret + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46826", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18899", "l": "AH2 + L-thyroxine => 3,3',5'-triiodo-L-thyronine + A + H(+) + iodide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761854", "l": "NFE2L2-dependent ME1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12542", "l": "AMP + diphosphate + L-alanyl-tRNA(Ala) => ATP + L-alanine + tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033509", "l": "USP9X binds Ub:PEX5L (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167419", "l": "The receptor:G-protein complex releases GDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694462", "l": "ABHD6,12 hydrolyse 3AG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928615", "l": "EFNBs bind SFKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24998", "l": "H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002466", "l": "Formation of allysine by LOX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134953", "l": "DHX36 or DHX9 binds MyD88 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68620", "l": "cortisone + H(+) + NADPH = 20beta-dihydrocortisone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56880", "l": "a 3beta-hydroxy-Delta(5)-steroid + NADP(+) = a 3-oxo-Delta(5)-steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30357", "l": "a quinone + H2O + methanol => a quinol + methane + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43958", "l": "H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate => 15-methylhexadecanoate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11298", "l": "2-oxoglutarate + 2 H(+) + NADPH => 2,5-dioxopentanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36289", "l": "7-methylxanthine + formaldehyde + H2O + NADP(+) => H(+) + NADPH + O2 + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32303", "l": "(2R)-homocitrate = (2R,3S)-homoisocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76416", "l": "Benzene is hydroxylated to phenol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190265", "l": "FGFR4 binds to FGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75236", "l": "L-fucono-1,5-lactone => L-fucono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432054", "l": "Aquaporin-1 passively transports water out of cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39291", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23111", "l": "D-arabinono-1,4-lactone + H2O <=> D-arabinonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70125", "l": "6-dehydro-28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47624", "l": "cis-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O", "d": []}, {"i": "EC:4.2.1.171", "l": "\"cis-L-3-hydroxyproline dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23058", "l": "cyanamide + H2O => urea", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017042", "l": "glycosylceramidase activity", "d": ["Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14591", "l": "chrysoeriol + H(+) + S-adenosyl-L-homocysteine => luteolin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5251942", "l": "Hikeshi binds HSP70s:ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50920", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 = chromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51990", "l": "18S-resolvin E1 => (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41409", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54900", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADH = hexadecanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265959", "l": "Phosphorylation of Chk2 by ATM upon DNA damage (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49304", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36924", "l": "(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42380", "l": "2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O = 2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.2", "l": "\"pyrroline-5-carboxylate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9681616", "l": "AP2 binds chlorpromazine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14494", "l": "H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] => ADP-D-ribose + L-arginyl-[dinitrogen reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19520", "l": "H2O + N,N-dimethylformamide <=> dimethylamine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983422", "l": "Disassembly of COPII coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39544", "l": "3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675473", "l": "SH2B binds JAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49176", "l": "12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672973", "l": "MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71911", "l": "cholate(out) + 2 Na(+)(out) = cholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617182", "l": "PRKACA phosphorylates PLN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37901", "l": "7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate => 2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68976", "l": "glycoursodeoxycholate + NADP(+) = 7-oxoglycolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54355", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653850", "l": "Defective SLC36A2 does not cotransport Gly, L-Pro with H+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39338", "l": "3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110307", "l": "REV1 binds AP-dsDNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218642", "l": "PTK2 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73878", "l": "(R)-adrenaline(out) <=> (R)-adrenaline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018826", "l": "RHOT2 hydrolyzes GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19684", "l": "ATP + biotin + CoA <=> AMP + biotinyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0099602", "l": "neurotransmitter receptor regulator activity", "d": ["A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679205", "l": "ULK1 phosphorylates Beclin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759176", "l": "NFE2L2-dependent HMOX1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201669", "l": "Beta-catenin translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48443", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol <=> a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65425", "l": "AMP(in) + NAD(+)(out) => AMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013024", "l": "RHOB binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20331", "l": "ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor] => ATP + L-seryl-[low-density-lipoprotein receptor]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24937", "l": "N-formimidoylglycine => H2O + imidazol-4-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788623", "l": "p-Y-STATs translocate to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70625", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33064", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin] => NADH + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22493", "l": "H2O + N-formimidoyl-L-glutamate => formamide + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32371", "l": "all-trans-violaxanthin + 2 L-ascorbate = all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate", "d": []}, {"i": "EC:1.23.5.1", "l": "\"violaxanthin de-epoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187575", "l": "Ubiquitination of phospho-p27/p21 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64587", "l": "2-hydroxyethane-1-sulfonate(out) + Na(+)(out) <=> 2-hydroxyethane-1-sulfonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37636", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.06379513530257", "identifiers": [{"i": "GO:1901505", "l": "carbohydrate derivative transmembrane transporter activity", "d": ["Enables the transfer of carbohydrate derivative from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210295", "l": "Interaction of DAP12 and NKG2D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174202", "l": "Degradation of multiubiquitinated Securin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59793", "l": "H2O + NADP(+) + yersinopine => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55475", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854466", "l": "VLDLR binds RELN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35714", "l": "acetate + succinyl-CoA <=> acetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000006", "l": "high-affinity zinc transmembrane transporter activity", "d": ["Enables the transfer of zinc ions (Zn2+) from one side of a membrane to the other, probably powered by proton motive force. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48219", "l": "H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24172", "l": "A + a 3-oxo-5beta-steroid = a 3-oxo-Delta(4)-steroid + AH2", "d": []}, {"i": "EC:1.3.99.6", "l": "\"3-oxo-5beta-steroid 4-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005362", "l": "low-affinity glucose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}, {"i": "REACT:R-HSA-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709179", "l": "DPP4 binds DPP4 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754974", "l": "ADK phosphorylates RBV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015419", "l": "ABC-type sulfate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928604", "l": "SFKs phosphorylate VAV2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23250", "l": "1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine => myo-inositol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45101", "l": "6-demethylmitomycin B + S-adenosyl-L-methionine => mitomycin B + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41765", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E)) => CMP + ganglioside GT3 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.92", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429732", "l": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67450", "l": "formyl-CoA + heptadecanal => (2R)-2-hydroxyoctadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981621", "l": "C3 convertases spontaneously dissociate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33801", "l": "H(+) + L-histidinal + NADH => L-histidinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106063", "l": "G protein-coupled folate receptor activity", "d": ["Combining with folate and transmitting the signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40409", "l": "1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052631", "l": "sphingolipid delta-8 desaturase activity", "d": ["Catalysis of the formation of a double bond between C8 and C9 of the long chain base of a sphingolipid. For example, sphinganine (d18:0) = 8-sphingenine (d18:1delta8); phytosphinganine (t18:0) = 8-phytosphingenine (t18:1delta8); and 4-sphingenine (18:1delta4) = 4,8-sphingadienine (d18:2delta4,8)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168445", "l": "PTP1B binds the GH receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731931", "l": "EDNRA binds selective ERAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447030", "l": "NrCAM binds Ankyrin-G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27714", "l": "GMP + H2O = guanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30964", "l": "7,9,9'-tri-cis-neurosporene + a quinone => 7,7',9,9'-tetra-cis-lycopene + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10631", "l": "phosphate + tRNA(n+1) <=> a ribonucleoside 5'-diphosphate + tRNA(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61991", "l": "cytidine(72) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62780", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38992", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.63", "l": "\"4-acetamidobutyrate deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65392", "l": "4 H(+) + L-pipecolate + malonyl-CoA + 2 NADPH = (8aS)-octahydroindolizin-1-one + CO2 + CoA + 2 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373722", "l": "Nephrin binds CASK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58410", "l": "H(+) + NADPH + undecanal => NADP(+) + undecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607746", "l": "PKC-delta is activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42038", "l": "7-oxolithocholate + H(+) + NADH => chenodeoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22020", "l": "ATP + H2O + molybdate(out) = ADP + H(+) + molybdate(in) + phosphate", "d": []}, {"i": "EC:7.3.2.5", "l": "\"ABC-type molybdate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374673", "l": "L1 binds RanBPM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008822", "l": "PPM1D dephosphorylates RUNX2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51030", "l": "7-chloroindole-3-pyruvate imine dimer + 2 H2O => 2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0043844", "l": "ADP-specific phosphofructokinase activity", "d": ["Catalysis of the reaction: ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56985", "l": "(2E,6E)-farnesyl diphosphate + H2O => (6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263496", "l": "Defective NAGLU does not hydrolyse Heparan sulfate chain(4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050343", "l": "trans-2-enoyl-CoA reductase (NAD+) activity", "d": ["Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71539", "l": "H(+)(out) + 2 nitrate(out) = H(+)(in) + 2 nitrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.20", "l": "\"long-chain-alcohol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54475", "l": "1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75107", "l": "32-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 32-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24770", "l": "chlorophyllide b + H(+) + NADH => 7(1)-hydroxychlorophyllide a + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757578", "l": "ALB binds PREDN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46668", "l": "21-hydroxyprogesterone + H(+) + NADPH = 5beta-dihydrodeoxycorticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34940", "l": "H2O + menaquinone-8 + selenite => menaquinol-8 + selenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75000", "l": "deoxyerythrostominol(in) => deoxyerythrostominol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65226", "l": "H(+) + NADPH + naphthalene-1,2-diol => (1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70752", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19903", "l": "alpha,beta-didehydrotryptophan + H2O2 => L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16906", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O => a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9633044", "l": "ESR binds STRN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61624", "l": "2-oxoglutarate + cadaverine = 5-aminopentanal + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41590", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183126", "l": "Factor B binds to surface-associated C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11811", "l": "bergaptol + S-adenosyl-L-methionine <=> bergapten + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-976801", "l": "Complement factor I complex formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45916", "l": "12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48807", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641205", "l": "RSPO:LGR binds ZNRF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.68", "l": "\"tentoxilysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10740", "l": "a secondary alcohol + NAD(+) = a ketone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102195", "l": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + D-lysinium(1+) + ATP <=> UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-D-lysine + ADP + hydrogenphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11207", "l": "apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043833", "l": "[methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase activity", "d": ["Catalysis of the reaction: [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M = [Co(I) methylamine-specific corrinoid protein] + H+ + methyl-coenzyme M. This reaction is the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9612219", "l": "ERBB4s80 binds to SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035982", "l": "Defective HEXB does not cleave the terminal GalNAc from HA fragments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296045", "l": "Activation of Potassium transport channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668735", "l": "RAC1:GTP binds NOX3 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388828", "l": "PD-1 binds B7DC and B7H1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51927", "l": "AH2 + menaquinone-9 <=> A + beta-dihydromenaquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49859", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17442", "l": "2-oxoglutarate + L-cysteine => 2-oxo-3-sulfanylpropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68437", "l": "(3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2 => (3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52064", "l": "13-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54518", "l": "(13R)-manoyl oxide + diphosphate => 8-hydroxycopalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784735", "l": "PCSK9:LDLR bind to Clathrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112385", "l": "Addition of nucleotides leads to transcript elongation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41410", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047038", "l": "D-arabinitol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-arabinitol + NAD+ = D-ribulose + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18190", "l": "[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose => [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018774", "l": "RHOBTB1 binds GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53972", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37615", "l": "(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655313", "l": "Activated FGFR4 mutants bind PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45511", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin beta-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67041", "l": "(3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + H(+) => asnovolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.13", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052917", "l": "dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase", "d": ["Catalysis of the addition of mannose to dolichyl-pyrophosphate Man7GlcNAc2 (also written as Man7GlcNAc2-PP-Dol) in alpha-(1->6) linkage, producing Man8GlcNAc2-PP-Dol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30828", "l": "UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62240", "l": "a thymidine(6-4)cytidine in DNA = a thymine-cytidine dinucleotide in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69142", "l": "Recruitment of Dna2 endonuclease (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15847", "l": "4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP => 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018784", "l": "(S)-2-haloacid dehalogenase activity", "d": ["Catalysis of the reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54982", "l": "[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195926", "l": "Association with M1 at cell membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42326", "l": "3 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534365", "l": "Slo3 Potassium Transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022881", "l": "protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34492", "l": "H2O + UDP-N,N'-diacetylbacillosamine => 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668395", "l": "CHMP7 binds CC2D1B (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34834", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate <=> N-acyl-15-methylhexadecasphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17265", "l": "trans-aconitate = cis-aconitate", "d": []}, {"i": "EC:5.3.3.7", "l": "\"aconitate Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10754", "l": "[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate => [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35458", "l": "5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2 <=> (25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17392", "l": "D-arabinitol + NAD(+) <=> D-ribulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48222", "l": "(2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75371", "l": "guanosine(in) = guanosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033738", "l": "methylenetetrahydrofolate reductase (ferredoxin) activity", "d": ["Catalysis of the reaction: 5-methyltetrahydrofolate + oxidized ferredoxin = 5,10-methylenetetrahydrofolate + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54466", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate => 1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0052595", "l": "aliphatic amine oxidase activity", "d": ["Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63202", "l": "(10bS,4aR)-oxomaritidine + NADP(+) => (10bS,4aR)-noroxomaritidine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36374", "l": "(2S)-hydroxybutanoate + NAD(+) <=> 2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38984", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71555", "l": "5-C(alpha)-glycyl-dTMP in DNA + H(+) = 5-aminoethyl-dUMP in DNA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140663", "l": "ATP-dependent FeS chaperone activity", "d": ["Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64932", "l": "dGTP + 2 H2O = dGMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27801", "l": "(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate <=> all-trans-octaprenyl diphosphate + 5 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.25.1", "l": "\"deoxyribonuclease (pyrimidine dimer)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38441", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031014", "l": "troponin T binding", "d": ["Binding to troponin T, the tropomyosin-binding subunit of the troponin complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13908", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37319", "l": "ATP + glycyl-L-methionine(out) + H2O = ADP + glycyl-L-methionine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071796", "l": "K6-linked polyubiquitin modification-dependent protein binding", "d": ["Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 6 in the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191763", "l": "snRNP:Snurportin complex formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604731", "l": "Autocatalytic activation of MMP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14418", "l": "acetyl phosphate + L-lysine => H(+) + N(6)-acetyl-L-lysine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389532", "l": "PP2A binds CTLA4 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.18", "l": "\"GDP-mannose 3,5-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66120", "l": "2-oxobutanoate + L-methionine = (2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34538", "l": "H(+) + hexadecanoyl-CoA + L-alanine <=> 1-deoxy-3-dehydrosphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10394", "l": "(E)-cinnamaldehyde + H(+) + NADPH => (E)-cinnamyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56615", "l": "L-cysteinyl-[protein] + NAD(+) <=> H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205118", "l": "TRAF6 polyubiquitinates NRIF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26043", "l": "acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-9-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76024", "l": "18-hydroxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 18-oxocortisol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52513", "l": "a quinone + trans-4-hydroxy-L-proline => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60350", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0047606", "l": "hydroxynitrilase activity", "d": ["Catalysis of the reaction: a hydroxynitrile = cyanide + an aldehyde or ketone."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033965", "l": "aculeacin-A deacylase activity", "d": ["Catalysis of the hydrolysis of the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side-chain."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106162", "l": "mRNA N-acetyltransferase activity", "d": ["Catalysis of the reaction: a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H+ + phosphate."]}, {"i": "RHEA:58480", "l": "a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29389", "l": "CDP + H(+) + phosphate => CTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59937", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41134", "l": "1-decanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-decanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26185", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23999", "l": "a ribonucleoside 5'-triphosphate + H2O <=> a ribonucleoside 5'-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48138", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate => ganglioside GM3 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102829", "l": "ajugose synthase activity", "d": ["Catalysis of the reaction: 2 verbascose <=> ajugose + stachyose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53971", "l": "apo-[BtrI ACP] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982617", "l": "CYGB:O2 dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33509", "l": "(2E)-hexadecenal + phosphoethanolamine => sphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70096", "l": "(R)-5-methyl-tetronate + o-quinone methide => peniphenone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48950", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69214", "l": "(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ADP + H(+) + phosphate => (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9710354", "l": "GSDME (1-270) binds cardiolipin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73806", "l": "AIR + CO2 => CAIR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102154", "l": "8C-naringenin dibenzoylmethane tautomer glucosyltransferase activity", "d": ["Catalysis of the reaction: 2,4,4',6-tetrahydroxydibenzoylmethane + UDP-alpha-D-glucose <=> 8C-glucosyl-2-hydroxynaringenin + UDP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047266", "l": "poly(ribitol-phosphate) beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: poly(ribitol phosphate) + UDP-D-glucose = beta-D-glucosylpoly(ribitol phosphate) + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22943", "l": "ATP + L-arginine <=> ADP + H(+) + N(omega)-phospho-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72245", "l": "guaiacol + H(+) + S-adenosyl-L-homocysteine => catechol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36657", "l": "descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine => desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16761", "l": "chlorohydroquinone + O2 = 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33102", "l": "acetyl-CoA + spermine <=> CoA + H(+) + N(1)-acetylspermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693148", "l": "BCKDK phosphorylates BCKDH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10589", "l": "4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH => 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75199", "l": "H2O + triuret = 1-carboxybiuret + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60068", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 = 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56104", "l": "2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 = 4,4'-diaponeurosporenal + 2 A + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71129", "l": "H(+)(out) + L-glutamine(in) + Na(+)(in) => H(+)(in) + L-glutamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64103", "l": "2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + TAN-1612", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177930", "l": "GAB1 phosphorylation by EGFR kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51948", "l": "(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72137", "l": "putrescine(in) => putrescine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49097", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine => 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16842", "l": "precorrin-2 + S-adenosyl-L-methionine => H(+) + precorrin-3A + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176956", "l": "Formation of GINS complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59559", "l": "H2O + N,N'-diacetylchitobiono-1,5-lactone <=> H(+) + N,N'-diacetylchitobionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39349", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+) => (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69155", "l": "spermine monoaldehyde <=> acrolein + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429860", "l": "DCP1-DCP2 complex decaps mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72163", "l": "chloride(out) + 2 Na(+)(out) + O-butanoyl-(R)-carnitine(out) = chloride(in) + 2 Na(+)(in) + O-butanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937807", "l": "SRC phosphorylates RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68977", "l": "glycoursodeoxycholate + NADP(+) => 7-oxoglycolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40510", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34253", "l": "1-deoxy-3-dehydrosphinganine + H(+) + NADPH => 1-deoxysphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3318415", "l": "ATF2 acetylates histone H2B, H4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24480", "l": "a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol", "d": []}, {"i": "EC:3.2.1.149", "l": "\"beta-primeverosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73577", "l": "CAD hexamer transforms L-Gln to CAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018807", "l": "RAC3 GDIs block activation of RAC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5604929", "l": "Activated protein C binds Protein S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63031", "l": "(15Z)-tetracosenamide + H2O <=> (15Z)-tetracosenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69784", "l": "(2-aminophenyl)succinate + succinyl-CoA => 2-(2-aminophenyl)succinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700120", "l": "PTN and MDK bind to PTPRZ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874685", "l": "CBL binds MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32225", "l": "AMP + H(+) + NADH + phosphate => (6S)-NADHX + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848339", "l": "PNPLA5 hydrolyzes TAG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418581", "l": "Activated P2Y purinoceptor 1 binds G-protein Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783880", "l": "PIPOX oxidises PPCA to P6C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647978", "l": "pro-RAS proteins are farnesylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306876", "l": "NLRP3 activation by small molecules (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11395", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O <=> 1D-myo-inositol 1,3,4-trisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448958", "l": "Nuclear translocation of p38 MAPK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21301", "l": "H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182986", "l": "CBL-mediated ubiquitination of CIN85 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56504", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202394", "l": "Translocation of CARMA1 to Plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50647", "l": "2-(3-methylsulfanyl)propylmalate <=> 3-(3-methylsulfanyl)propylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64433", "l": "H(+)(out) + L-alanyl-L-prolylglycine(out) => H(+)(in) + L-alanyl-L-prolylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46189", "l": "an aliphatic nitrile + 2 H2O => a carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165179", "l": "Formation of TSC1:TSC2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43301", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0035033", "l": "histone deacetylase regulator activity", "d": ["Binds to and modulates the activity of histone deacetylase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31689", "l": "(9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50527", "l": "acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43644", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-CoA = 3-oxohexadecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199456", "l": "PTEN dephosphorylates PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186785", "l": "RNF111 ubiquitinates SMAD7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26503", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose => 2 H(+) + ternatin C5 + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74830", "l": "UDP-alpha-D-galacturonate(in) + UMP(out) <=> UDP-alpha-D-galacturonate(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15873", "l": "[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)", "d": []}, {"i": "EC:2.4.1.242", "l": "\"NDP-glucose--starch glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578712", "l": "Importin-8 binds AGO2:miRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51130", "l": "AH2 + an aldehyde + NH4(+) => A + an aliphatic amine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25399", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate", "d": []}, {"i": "EC:5.4.4.6", "l": "\"9,12-octadecadienoate 8-hydroperoxide 8S-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209760", "l": "Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592316", "l": "Initial activation of proMMP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-264622", "l": "Cho is acetylated to AcCho by CHAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64717", "l": "NADP(+) + propanal => acrolein + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32342", "l": "(+)-thujan-3-ol + NADP(+) <=> (+)-thujan-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700154", "l": "Active ALK binds SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-984606", "l": "Kinesin-5 is a homotetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2574845", "l": "AJUBA binds centrosome-associated AURKA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18208", "l": "AH2 + O2 + progesterone <=> 11alpha-hydroxyprogesterone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55011", "l": "(1R,4S)-1-hydroxylimonen-2-one + NADPH + O2 <=> (3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66985", "l": "3-methylbutanoyl-CoA + H2O => CoA + H(+) + isovalerate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54720", "l": "N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58971", "l": "1-naphthaldehyde + H2O + O2 <=> 1-naphthoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862300", "l": "LYZ binds bacterial peptidoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199203", "l": "PANK1/3/4 phosphorylate PanK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757578", "l": "ALB binds PREDN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798082", "l": "TP53 family members bind the CASP1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25661", "l": "(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12995", "l": "cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein] => cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033421", "l": "CCU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CCU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41987", "l": "NAD(+) + propan-2-ol <=> acetone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64488", "l": "acetyl-CoA + 5 H(+) + holo-[ACP] + 5 malonyl-CoA = 3,5,7,9,11-pentaoxododecanoyl-[ACP] + 5 CO2 + 6 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47810", "l": "epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9817575", "l": "ERO1B oxidizes P4HB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917700", "l": "MVB Vesicle Formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43535", "l": "a ribonucleoside 3',5'-bisphosphate + H2O <=> a ribonucleoside 5'-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62827", "l": "beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507868", "l": "Aquaporins passively transport water into cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28180", "l": "colnelenate + H2O => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549475", "l": "Expression of NR1D1 (REV-ERBA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73838", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate <=> 2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679839", "l": "RIPK1 binds ponatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190065", "l": "Activated TrkA receptor internalizes to endosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008839", "l": "4-hydroxy-tetrahydrodipicolinate reductase", "d": ["Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641206", "l": "RSPOs bind LGRs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004568", "l": "chitinase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951676", "l": "RUNX3 binds TEADs and YAP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42638", "l": "A + H2O + L-alanine + thio-Mo-molybdopterin => AH2 + L-cysteine + Mo-molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13598", "l": "1,4-diguanidinobutane + H2O => agmatine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31320", "l": "(2R)-3-phosphoglycerate + UDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.108", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23566", "l": "2 berberine + 2 H2O => 2 columbamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473186", "l": "FSTL3 binds Activin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53769", "l": "allocholate + allodeoxycholoyl-CoA => allocholoyl-CoA + allodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717382", "l": "SCN9A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-936563", "l": "ISGylation of DDX58 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47689", "l": "cis-4-hydroxy-L-proline + NADP(+) => Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-166015", "l": "Association of LBP with LPS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71306", "l": "chloride(out) + L-methionine(out) + 2 Na(+)(out) <=> chloride(in) + L-methionine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672011", "l": "p-AMPK:AMP binds the ULK complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42299", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] <=> a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130504", "l": "Cleavage of lip22 to lip10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692749", "l": "CDC14A,B bind MAPK6 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67378", "l": "glycine + L-histidine => glycyl-L-histidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63622", "l": "AMP + diphosphate + dodecanoyl-[ACP] => ATP + dodecanoate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1671691", "l": "PRLR-bound STAT5 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22087", "l": "(S)-2,3-diaminopropanoate + H(+) + H2O <=> 2 NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25703", "l": "N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050275", "l": "scopoletin glucosyltransferase activity", "d": ["Catalysis of the reaction: scopoletin + UDP-D-glucose = H+ + scopolin + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000342", "l": "RNA cap 4 binding", "d": ["Binding to a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670114", "l": "Histone H3.3 deposition at telomere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021520", "l": "NOTCH3 binds WWP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202168", "l": "Phosphorylation of ZAP-70 by Lck (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706319", "l": "Active FLT3 binds to SLA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29511", "l": "(2E,6E)-farnesyl diphosphate = (+)-valencene + diphosphate", "d": []}, {"i": "EC:4.2.3.73", "l": "\"valencene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51063", "l": "5alpha-androst-1-ene-3,17-dione + A <=> AH2 + androsta-1,4-diene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444433", "l": "Cho transports from the extracellular space to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71620", "l": "(S)-malate(in) + 2 thiosulfate(out) => (S)-malate(out) + 2 thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20050", "l": "1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O => 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39450", "l": "(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004740", "l": "pyruvate dehydrogenase (acetyl-transferring) kinase activity", "d": ["Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106321", "l": "S-(hydroxymethyl)glutathione dehydrogenase NADP activity", "d": ["Catalysis of the reaction: S-(hydroxymethyl)glutathione + NADP+ = S-formylglutathione + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24293", "l": "acetyl-CoA + L-glutamate => CoA + H(+) + N-acetyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29222", "l": "a menaquinone + sn-glycerol 3-phosphate <=> a menaquinol + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964619", "l": "PAK1 binds ARHGEF6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762333", "l": "ANGPTL4 binds to CDH11v (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57857", "l": "(E)-feruloyl-CoA + 2-oxoglutarate + O2 => (E)-6-hydroxyferuloyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698000", "l": "FLT3 mutants:GRB2 bind GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37896", "l": "H2O + protodioscin => 26-deglucoprotodioscin + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.2", "l": "\"phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.06379513530257", "identifiers": [{"i": "GO:0008528", "l": "G protein-coupled peptide receptor activity", "d": ["Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.71", "l": "\"sortase B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18046", "l": "6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O => alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62066", "l": "2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH => 2-deoxy-D-glucose 6-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71264", "l": "chloride(out) + L-proline(out) + 2 Na(+)(out) => chloride(in) + L-proline(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50232", "l": "8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.20", "l": "\"heme oxygenase (biliverdin-producing, ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42261", "l": "H(+) + heptanoyl-CoA + malonyl-[ACP] => 3-oxononanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73167", "l": "CoA(out) + NAD(+)(in) = CoA(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65562", "l": "H2O + kynurenate + L-glutamate => 2-oxoglutarate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67055", "l": "AH2 + asnovolin J + O2 <=> A + asnovolin A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49036", "l": "(-)-pluviatolide + S-adenosyl-L-methionine = (-)-bursehernin + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.323", "l": "\"(-)-pluviatolide 4-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848338", "l": "PNPLA4 hydrolyzes TAG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73093", "l": "AMP(in) + FMN(out) => AMP(out) + FMN(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63734", "l": "UDP + zolarsartan O-beta-D-glucuronoside => UDP-alpha-D-glucuronate + zolasartan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007546", "l": "E2F6 binds RAD51 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52630", "l": "a fatty acid + an L-alpha-amino acid => an N-fatty-acyl-L-alpha-amino acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17324", "l": "L-tryptophan + S-adenosyl-L-methionine <=> 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9769235", "l": "MAGED1 binds NPAS4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382057", "l": "Release of novel PDGFs as latent factors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44838", "l": "globoside NOR2 (d18:1(4E)) + H(+) + UDP => globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55876", "l": "apo-[aequorin] + coelenterazine = apo-[aequorin]--coelenterazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70209", "l": "sphinga-4E,14Z-dienine-1-phosphate(out) => sphinga-4E,14Z-dienine-1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75162", "l": "NAD(+) + TTP <=> H(+) + NADP(+) + TDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507869", "l": "Aquaporins passively transport glycerol into cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707516", "l": "FeHM dissociates from MetHb (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48051", "l": "ganglioside GM1 (d18:1(4E)) + H2O <=> D-galactose + ganglioside GM2 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11022", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5-trisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22730", "l": "L-selenocysteinyl-tRNA(Sec) + phosphate => H(+) + L-seryl-tRNA(Sec) + selenophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67878", "l": "3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24572", "l": "[(1->4)-alpha-D-glucosyl](n) + sucrose = [(1->4)-alpha-D-glucosyl](n+1) + D-fructose", "d": []}, {"i": "EC:2.4.1.4", "l": "\"amylosucrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419645", "l": "Dimerization of LIMK1 by Hsp90 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157933", "l": "NICD2 traffics to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012556", "l": "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18978", "l": "a quinone + sn-glycerol 3-phosphate => a quinol + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65307", "l": "2-oxoglutarate + O2 + verruculide A <=> chrodrimanin T + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69713", "l": "beta-D-glucose + N-hexadecanoylsphinganine => beta-D-glucosyl-(1<->1')-N-hexadecanoylsphinganine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48129", "l": "(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-farnesyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15189", "l": "2 Fe(III)-[cytochrome c553] + formate = CO2 + 2 Fe(II)-[cytochrome c553] + H(+)", "d": []}, {"i": "EC:1.17.2.3", "l": "\"formate dehydrogenase (cytochrome c-553)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72339", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + guaiacol + H(+) = catechol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68062", "l": "a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062144", "l": "L-propargylglycine synthase activity", "d": ["Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate = chloride + H+ + L-propargylglycine."]}, {"i": "RHEA:59892", "l": "L-2-amino-4-chloropent-4-enoate = chloride + H(+) + L-propargylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31237", "l": "(4R)-4-hydroxy-2-oxoglutarate + L-glutamate => (4S)-4-hydroxy-L-glutamate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19498", "l": "H(+) + L-aspartate => beta-alanine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.3.18", "l": "\"dimethylargininase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662606", "l": "MT3 binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71909", "l": "H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide => GDP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37789", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033154", "l": "ABC-type oligogalacturonide transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligogalacturonide(out) = ADP + phosphate + oligogalacturonide(in)."]}, {"i": "TCDB:3.A.1.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14458", "l": "glyoxylate + H2O + pentanoyl-CoA => 3-propylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877361", "l": "Pyrin binds ASC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15654", "l": "ATP + beta-D-fructose 6-phosphate => ADP + beta-D-fructose 2,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47032", "l": "AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": []}, {"i": "EC:2.8.1.13", "l": "\"tRNA-uridine 2-sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64197", "l": "an N-(fatty acyl)-L-lysine + H2O => a fatty acid + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71783", "l": "MDH2 reduces OA to MAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42969", "l": "cytidine(56) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043827", "l": "tRNA (adenine-57, 58-N(1)-) methyltransferase activity", "d": ["Catalysis of the methylation of adenine-57 and adenine-58 in the T-loop of tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65301", "l": "2-oxoglutarate + chrodrimanin C + O2 => CO2 + H2O + succinate + verruculide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2106625", "l": "Duplex siRNA is loaded into Argonaute (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36799", "l": "a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66376", "l": "D-erythrose 4-phosphate + H2O = D-erythrose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18447", "l": "5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => H2O + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0005412", "l": "glucose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65216", "l": "3-oxododecanoyl-CoA + H2O = 3-oxododecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16912", "l": "2 Fe(III)-[cytochrome c] + glycine + H2O <=> 2 Fe(II)-[cytochrome c] + glyoxylate + 2 H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33681", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43674", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865182", "l": "OTUD7A hydrolyses K11diUb (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70500", "l": "D-galactose(out) + 2 Na(+)(out) => D-galactose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848436", "l": "PTK6 phosphorylates CDKN1B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40887", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + octadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51149", "l": "a primary alcohol + 2 oxidized [azurin] => an aldehyde + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8863727", "l": "STON2 is neddylated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928657", "l": "MMP2,9 cleave EPHB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088130", "l": "PLK1 binds FOXM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22852", "l": "L-serine + pyruvate = 3-hydroxypyruvate + L-alanine", "d": []}, {"i": "EC:2.6.1.51", "l": "\"serine--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16939", "l": "1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-alkyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53930", "l": "a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine => a tertiary amine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848124", "l": "PTK6 phosphorylates STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.644186068201407", "identifiers": [{"i": "GO:0016860", "l": "intramolecular oxidoreductase activity", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683593", "l": "ATG7:ATG3:LC3 dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950292", "l": "Expression of Heterogeneous nuclear ribonucleoproteins A2/B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874083", "l": "p-Y397-PTK2 binds SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0005246", "l": "calcium channel regulator activity", "d": ["Modulates the activity of a calcium channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30186", "l": "L-galactonate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27787", "l": "2-oxoglutarate + CoA + NAD(+) => CO2 + NADH + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22318", "l": "13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP => 13-hydroxydocosanoate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37121", "l": "2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe) => 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102240", "l": "soyasapogenol B glucuronide galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-galactose + soyasapogenol B 3-O-beta-glucuronate <=> H+ + UDP + soyasaponin III."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49150", "l": "dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26268", "l": "dehydroabietadienal + H2O + NADP(+) <=> dehydroabietate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64186", "l": "(9Z)-octadecenoate + L-tyrosine => H2O + N-(9Z-octadecenoyl)-L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72766", "l": "anthocyanin A10 + malonyl-CoA <=> anthocyanin A11 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66896", "l": "4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052788", "l": "d-4,5 unsaturated beta-glucuronyl hydrolase activity", "d": ["Catalysis of the hydrolysis of the glycosidic bond in an unsaturated saccharide between the unsaturated glucuronyl residue at the nonreducing terminus and the saccharide linked to the residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40377", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64079", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 <=> 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042469", "l": "versicolorin reductase activity", "d": ["Catalysis of the reduction of versicolorin A to sterigmatocystin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11118", "l": "an N-acetylalkane-alpha,omega-diamine + CoA + H(+) => acetyl-CoA + an alkane-alpha,omega-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37729", "l": "1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070040", "l": "rRNA (adenine-C2-)-methyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + rRNA containing C2-methyladenine(2503) in 23S rRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483186", "l": "PC is converted to PS by PTDSS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63634", "l": "a long-chain fatty acyl-[ACP] + AMP + H(+) => a long-chain fatty acyl-AMP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19941", "l": "norcoclaurine + S-adenosyl-L-methionine = coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.35", "l": "\"hyaluronoglucosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50719", "l": "dimethyl sulfone + FMNH2 + O2 <=> FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045130", "l": "keratan sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68999", "l": "2-oxoglutarate + gibberellin A9 + O2 <=> CO2 + gibberellin A4 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66151", "l": "2-phenylethylamine + acetyl-CoA <=> CoA + H(+) + N-(2-phenylethyl)acetamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649856", "l": "Oxidative damage to the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975865", "l": "IRAK4 autophosphorylation within the complex activated TLR:MyD88 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68739", "l": "ganoderate TR + O2 + reduced [NADPH--hemoprotein reductase] <=> ganoderate Jc + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212222", "l": "PRC2 recruits DNA methyltransferases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62624", "l": "[glutaredoxin]-dithiol + a hydroperoxide = [glutaredoxin]-disulfide + an alcohol + H2O", "d": []}, {"i": "EC:1.11.1.25", "l": "\"glutaredoxin-dependent peroxiredoxin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4837364", "l": "Secretion of SOD3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202453", "l": "Auto-ubiquitination of TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71410", "l": "7beta-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5660662", "l": "ASC binds Caspase-8 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980078", "l": "NOTCH1 stimulates HES5 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174446", "l": "Removal of remaining Flap from the C-strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8856945", "l": "PP2A methylation by LCMT1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15627", "l": "Co-precorrin-6A + H(+) + NADH => Co-precorrin-6B + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35593", "l": "H(+) + hydrogen sulfide + (n-1) sulfur => H2 + n sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56218", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP => O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45440", "l": "H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45335", "l": "7,8-dihydroneopterin + O2 <=> 7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56422", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein] => apo-[D-alanyl-carrier protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44171", "l": "dodecanoate + 2 H(+) + NADH <=> dodecanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389756", "l": "AKT interacts and phosphorylates Cot (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0050786", "l": "RAGE receptor binding", "d": ["Binding to a RAGE receptor, the receptor for advanced glycation end-products."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58192", "l": "dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin = dihydrobisanhydrobacterioruberin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21953", "l": "5alpha-pregnane-3,20-dione + NADP(+) => H(+) + NADPH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28523", "l": "D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052715", "l": "mannosyl-diinositol phosphorylceramide phospholipase activity", "d": ["Catalysis of the reaction: mannosyl-diinositol phosphorylceramide + H2O = C26-phytoceramide + mannosyldiphosphorylinositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.55", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396395", "l": "HSPG2 (perlecan) binds alpha-dystroglycan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35538", "l": "cyclo(L-phenylalanyl-L-leucyl) + O2 <=> cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52966", "l": "H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP => hyodeoxycholate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40854", "l": "FAD + H(+) + pentadecanoyl-CoA <=> (2E)-pentadecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54942", "l": "3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP] => (3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16015", "l": "AMP + diphosphate + glycyl-tRNA(Gly) => ATP + glycine + tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48845", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.116", "l": "\"3-hydroxypropionyl-CoA dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981353", "l": "RASA1 stimulates RAS GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029555", "l": "NR1H2,3 binds the ABCG8 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939201", "l": "ESR dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12709", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.137", "l": "\"phosphatidylinositol 3-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944214", "l": "Association of procollagen type I (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.-", "l": "\"With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52089", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24454", "l": "[protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine => L-glutamyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56050", "l": "daidzein 7-O-beta-D-glucoside + UDP => daidzein + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15048", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) <=> (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353014", "l": "2-phosphoglycerate <=> 3-phosphoglycerate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65606", "l": "CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + eicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727607", "l": "MME:Zn2+ binds sacubitrilat (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13063", "l": "glutathione S,S-dioxide + H(+) => O2 + S-sulfanylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31880", "l": "(S)-2,3-epoxysqualene => beta-seco-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22787", "l": "(2R)-O-phospho-3-sulfolactate <=> H(+) + phosphoenolpyruvate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23757", "l": "D-arabinono-1,4-lactone + O2 => dehydro-D-arabinono-1,4-lactone + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693599", "l": "Association of Ku heterodimer with ends of DNA double-strand break (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047472", "l": "3-carboxy-cis,cis-muconate cycloisomerase activity", "d": ["Catalysis of the reaction: 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.18", "l": "\"glucuronate-2-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849646", "l": "SPINK5(490-624) binds KLK5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912627", "l": "CBL ubiquitinates PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693761", "l": "FA2H hydroxylates CERA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018807", "l": "RAC3 GDIs block activation of RAC3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23820", "l": "GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O", "d": []}, {"i": "EC:4.2.1.47", "l": "\"GDP-mannose 4,6-dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247497", "l": "ERBB3 binds neuregulins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50379", "l": "a ceramide(in) + ATP + H2O <=> a ceramide(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.109", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27999", "l": "H2O + thiamine diphosphate => H(+) + phosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615023", "l": "PLXNA4 gene expression is stimulated by FOXO6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445700", "l": "Myosin Binds ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67015", "l": "a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11958", "l": "cholesterol + D-glucose => cholesteryl 3-beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036470", "l": "tyrosine 3-monooxygenase activator activity", "d": ["Binds to and increases the activity of tyrosine 3-monooxygenase (tyrosine hydroxylase)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952128", "l": "RUNX3 binds TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55047", "l": "(3E,5Z)-tetradecadienoyl-CoA + H2O <=> (3E,5Z)-tetradecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636396", "l": "lpdC binds to CORO1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46114", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22389", "l": "acetyl-CoA + N(6)-hydroxy-L-lysine => CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60324", "l": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.359", "l": "\"[histone H3]-lysine(36) N-trimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647631", "l": "GSDMD (1-275) binds PIPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873923", "l": "STARD10 binds LPCAT1 and PC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928615", "l": "EFNBs bind SFKs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20049", "l": "1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide", "d": []}, {"i": "EC:3.5.4.19", "l": "\"phosphoribosyl-AMP cyclohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701147", "l": "TRPV1 binds TRPV1 blockers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15159", "l": "H2O + homogentisate + NADP(+) => 4-hydroxyphenylacetate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854981", "l": "SHC1 in the RET complex is phosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58818", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate => ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54988", "l": "4 e(-) + 4 H(+)(in) + O2(in) = 2 H2O(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047244", "l": "N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-N-acetyl-D-mannosamine = N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168376", "l": "STIM1 oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47119", "l": "eicosanoate + glycine <=> H2O + N-eicosanoylglycinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71426", "l": "3,3',5-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) <=> 3,3',5-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45645", "l": "H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-hexadecanoylsphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12532", "l": "coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane", "d": []}, {"i": "EC:2.8.4.1", "l": "\"coenzyme-B sulfoethylthiotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58172", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = beta-pinacene + diphosphate", "d": []}, {"i": "EC:4.2.3.200", "l": "\"beta-pinacene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754130", "l": "CDK4 inhibitors bind CDK4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050196", "l": "[phosphorylase] phosphatase activity", "d": ["Catalysis of the reaction: [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37642", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25471", "l": "(2E,6E)-farnesyl diphosphate <=> beta-himachalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428917", "l": "G13 activation by TP receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43861", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809309", "l": "MTMR6 binds MTMR9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22482", "l": "4-nitroquinoline N-oxide + 2 H(+) + 2 NADH => 4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56495", "l": "hederagenin + O2 + reduced [NADPH--hemoprotein reductase] <=> gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614614", "l": "Cysteine is degraded to serine and H2S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49206", "l": "20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33128", "l": "H2O + salicin-6-phosphate => beta-D-glucose 6-phosphate + salicyl alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73501", "l": "4',7-dihydroxy-3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',7-trihydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59623", "l": "H2O + N(2)-(4-aminobutanoyl)-L-lysine <=> 4-aminobutanoate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111970", "l": "PKC phosphorylates GRK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560517", "l": "Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174157", "l": "Degradation of multiubiquitinated Cyclin B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201611", "l": "Caspase-mediated cleavage of Rock-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38614", "l": "NAD(+) <=> cyclic ADP-beta-D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0051995", "l": "Se-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the selenium atom of an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28433", "l": "D-allose 6-phosphate <=> D-allulose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34222", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60338", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66061", "l": "2-oxohexanoate + L-kynurenine => H2O + kynurenate + L-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205231", "l": "Dimerization of KIT upon SCF binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33870", "l": "(S)-2-ureidoglycine + glyoxylate <=> glycine + N-carbamoyl-2-oxoglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48148", "l": "ganglioside GT1b (d18:1(4E)/18:0) + H2O = ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66030", "l": "(5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734730", "l": "ORC1 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607737", "l": "BCL10 oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102533", "l": "genkwanin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: genkwanin + S-adenosyl-L-methionine <=> H+ + apigenin-7,4'-dimethyl ether + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9613497", "l": "Unwinding DNA for the nascent transcript (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20111", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ADP => alpha-D-ribose 1,5-bisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445064", "l": "Activation of Rac1 by VAV2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.-.-", "l": "\"Catalysing the translocation of inorganic cations\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694421", "l": "PP6 dephosphorylates SEC24 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25459", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-humulene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944362", "l": "TCF/LEF:CTNNB1 bind canonical WNT target promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37593", "l": "1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625406", "l": "FOXO1,FOXO3 bind KLF4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389348", "l": "Activation of Rac1 by pVav1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51567", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30873", "l": "2-deoxy-D-ribose 5-phosphate + ADP + H(+) => 2-deoxy-D-ribose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.5", "l": "\"ABC-type lipopolysaccharide transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65599", "l": "4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183126", "l": "Factor B binds to surface-associated C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358789", "l": "Self-ubiquitination of RNF41 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.3.1", "l": "\"nitroalkane oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60159", "l": "ATP + D-galactose(out) + H2O <=> ADP + D-galactose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791363", "l": "TP53 stimulates ARID3A gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53238", "l": "(24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => desmosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66417", "l": "ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O => ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51984", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647994", "l": "RAS proteins are depalmitoylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69308", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate = phenylacetonitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67700", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73035", "l": "Co(2+)(out) + H(+)(out) = Co(2+)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44627", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64787", "l": "S-ethyl-L-cysteine <=> 2-aminoprop-2-enoate + ethanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140407", "l": "L-alanine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-alanine(in) = H+(in) + L-alanine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690873", "l": "ACO1 binds 4Fe-4S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10178", "l": "(R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH => (2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33174", "l": "D-maltose(in) <=> D-maltose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58361", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 => (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70697", "l": "chloride(in) + glycine(in) + 3 Na(+)(in) => chloride(out) + glycine(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56334", "l": "AMP + ATP + H(+) => 5'-triphosphoadenylyl-(2'->5')-adenosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71704", "l": "taurocholate(out) => taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433506", "l": "Phosphorylation of APS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65894", "l": "H2O + xanthurenate => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182594", "l": "Association of INK4 family proteins with CDK4/6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31260", "l": "but-3-ynal + H2O + NAD(+) => 3-butynoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164617", "l": "Elongation of Extended Telomeric Chromosome End (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444523", "l": "CXCR5 binds CXCL13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013023", "l": "RHOB GEFs activate RHOB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50798", "l": "prostaglandin A2-S-(R)-glutathione => glutathione + prostaglandin A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38898", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0005452", "l": "solute:inorganic anion antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050518", "l": "2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity", "d": ["Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37166", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75755", "l": "(10E)-octadecenoate + H2O = 10-hydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70309", "l": "cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine => beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39289", "l": "dimethylamine + methyl-Co(III)-[trimethylamine-specific corrinoid protein] => Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18998", "l": "CTP + H(+) + phosphocholine => CDP-choline + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666433", "l": "IgG binds the surface of the amastigote form of Leishmania (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021596", "l": "Membrane estrogen receptors bind SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29247", "l": "3 H(+)(out) + 2 Na(+)(in) = 3 H(+)(in) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62461", "l": "3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23236", "l": "[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol", "d": []}, {"i": "EC:3.1.1.61", "l": "\"protein-glutamate methylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69074", "l": "Formation of Processive Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19787", "l": "clavaminate + CO2 + H2O + succinate => 2-oxoglutarate + dihydroclavaminate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678925", "l": "NR3C1 binds NR3C1 agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517850", "l": "TLR2-1 : TLR1-2 heterodimer binds to its ligand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001078", "l": "(1->6)-beta-D-glucan binding", "d": ["Binding to (1->6)-beta-D-glucan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42150", "l": "a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73257", "l": "(2S)-naringenin 4',7-dimethyl ether + H(+) + S-adenosyl-L-homocysteine => (2S)-sakuranetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008767", "l": "UDP-galactopyranose mutase activity", "d": ["Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31392", "l": "15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) => all-trans-4,4'-diapolycopene + 4 FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730841", "l": "Phosphorylation and activation of VAV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821931", "l": "BOD1L1 binds SET1A complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.43", "l": "\"prepilin peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73974", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51032", "l": "7-chloroindole-3-pyruvate imine dimer = dichlorochromopyrrolate + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004133", "l": "glycogen debranching enzyme activity", "d": ["Catalysis of the cleavage of branch points in branched glycogen polymers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35852", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682020", "l": "MRN complex binds shortened telomeres (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42893", "l": "5'-deoxyadenosine + H(+) + H2O => 5'-deoxyinosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63516", "l": "biphenyl-2,2',3-triol + H(+) + NADH + O2 = biphenyl-2,2',3,3'-tetraol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0016420", "l": "malonyltransferase activity", "d": ["Catalysis of the transfer of a malonyl (HOOC-CH2-CO-) group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140787", "l": "phosphate ion uniporter activity", "d": ["Catalysis of the active transport of a phosphate ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2768999", "l": "NOTCH1 PEST domain mutants bind JAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070968", "l": "pyrroloquinoline quinone binding", "d": ["Binding to pyrroloquinoline quinone, PQQ, the coenzyme or the prosthetic group of certain alcohol dehydrogenases and glucose dehydrogenases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688838", "l": "RIPK3 binds STUB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53131", "l": "delta-carotene <=> epsilon-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705584", "l": "HMGCR dimer binds statins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62611", "l": "glutathione + H(+) + hydrogen sulfide + ubiquinone-10 <=> S-sulfanylglutathione + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70323", "l": "2,3-dioxo-L-gulonate = 2-carboxy-L-lyxonolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52036", "l": "H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate = L-isoleucine + tuberonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700149", "l": "Active ALK binds PLCG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65454", "l": "CoA + ethyl hexanoate => ethanol + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34878", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) <=> 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47911", "l": "6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O <=> 6-deoxy-6-sulfo-D-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65572", "l": "(-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] = (-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60945", "l": "quercetin + S-adenosyl-L-methionine => H(+) + isorhamnetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15241", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.105", "l": "\"taxane 10beta-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0004596", "l": "peptide alpha-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990624", "l": "guanyl nucleotide exchange factor inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a guanyl nucleotide exchange factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668714", "l": "RAC1:GTP binds NOX1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0034040", "l": "ATPase-coupled lipid transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14306", "l": "ATP + L-proline + tRNA(Pro) => AMP + diphosphate + L-prolyl-tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67458", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70657", "l": "H(+)(out) + sarcosine(out) => H(+)(in) + sarcosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66677", "l": "(2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide => 4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25141", "l": "3-amino-2-oxopropyl phosphate + CO2 => (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18626", "l": "D-galactose + NADP(+) => D-galactono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75113", "l": "4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 32-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13624", "l": "4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose <=> 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16537", "l": "(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate", "d": []}, {"i": "EC:3.1.3.76", "l": "\"lipid-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202721", "l": "JAM2 binds JAM3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178218", "l": "SMAD7:SMURF complex binds to phosphorylated TGFBR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609738", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN2C (GRIN2C) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110311", "l": "POLZ extends translesion synthesis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62263", "l": "2 hydrogencarbonate(out) + Mn(2+)(out) <=> 2 hydrogencarbonate(in) + Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082391", "l": "Trimerization of HSF1 in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.29", "l": "\"Kdo2-lipid A phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60200", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate", "d": []}, {"i": "EC:1.14.11.66", "l": "\"[histone H3]-trimethyl-L-lysine(9) demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028724", "l": "AMOT proteins bind YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53450", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507871", "l": "Aquaporins passively transport glycerol out of cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800044", "l": "TP53 stimulates IGFBP3 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67196", "l": "H2O + N-acetylserotonin = acetate + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73620", "l": "CTP(out) + GTP(in) => CTP(in) + GTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48945", "l": "ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39925", "l": "1-O-octadecyl-sn-glycerol + H(+) + phosphocholine => 1-O-octadecyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940554", "l": "MMP2 cleaves OPTC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43762", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12] => acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21548", "l": "H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] = acetate + L-lysyl-[alpha-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43491", "l": "7(1)-hydroxychlorophyll a + NAD(+) <=> chlorophyll b + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62041", "l": "H2O + N-(octanoyl)-sphing-4-enine-1-phosphate => N-octanoylsphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604368", "l": "Autocatalytic activation of bound proMMP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928657", "l": "MMP2,9 cleave EPHB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62330", "l": "(+)-malbrancheamide + FADH2 => (+)-isomalbrancheamide B + chloride + FAD + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35064", "l": "H2O + pyrazinamide => NH4(+) + pyrazine-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371582", "l": "HSBP1 binds HSF1 trimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16288", "l": "D-octopine + H2O + NAD(+) <=> H(+) + L-arginine + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658435", "l": "RAS GAPs bind RAS:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74141", "l": "petunidin 3-O-beta-D-glucoside + UDP => petunidin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71118", "l": "H(+) + hispidin + NADH + O2 <=> 3-hydroxyhispidin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51964", "l": "2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72333", "l": "3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => 3-hydroxy-4-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9621179", "l": "Cinaciguat binds sGC:NO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75169", "l": "CDP + H(+) + NADP(+) => CTP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63626", "l": "AMP + H(+) + hexadecanoyl-[ACP] => hexadecanoyl-AMP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38649", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+) => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.15", "l": "\"chlorophyllide a reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67307", "l": "3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 <=> H2O2 + myceliothermophin E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17244", "l": "an alpha-amino acid ester + H2O <=> an alcohol + an alpha-amino acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56853", "l": "reumycin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + toxoflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781840", "l": "ERCC6 binds stalled RNA Pol II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18207", "l": "11alpha-hydroxyprogesterone + A + H2O => AH2 + O2 + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20593", "l": "H2O + N-acetyl-D-glucosamine = acetate + D-glucosamine", "d": []}, {"i": "EC:3.5.1.33", "l": "\"N-acetylglucosamine deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670416", "l": "Recruitment of STATs by KIT mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27448", "l": "NADP(+) + xylitol <=> D-xylose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693536", "l": "ATM phosphorylates MDC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102396", "l": "9-cis-10'-apo-beta-carotenal cleavage oxygenase activity", "d": ["Catalysis of the reaction: 9-cis-10'-apo-beta-carotenal + 2 O2 <=> carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55104", "l": "3-oxoheptanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyheptanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18953", "l": "L-erythro-7,8-dihydrobiopterin + NADP(+) = H(+) + NADPH + sepiapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41458", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034778", "l": "2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA = 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50287", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20062", "l": "2'-deoxycytidine + a ribonucleoside 5'-triphosphate => a ribonucleoside 5'-diphosphate + dCMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50314", "l": "butanal + CO2 => 2-oxopentanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63659", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796209", "l": "Expression of FOXA2 in the anterior primitive streak (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25562", "l": "9beta-pimara-7,15-diene + diphosphate => 9alpha-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73373", "l": "(R)-pantothenate(in) + 2 Na(+)(in) => (R)-pantothenate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018649", "l": "tetrahydrofuran hydroxylase activity", "d": ["Catalysis of the reaction: tetrahydrofuran + O2 + 2 H+ + 2 e- = H2O + 2-hydroxytetrahydrofuran."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684006", "l": "KPNA2 translocates NBN to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433506", "l": "Phosphorylation of APS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549322", "l": "OCT1 transports organic cations out of hepatic cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67962", "l": "4-methylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine => 4-amino-L-phenylalanine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29894", "l": "ATP + H2O + L-histidine(out) <=> ADP + H(+) + L-histidine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14790", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33774", "l": "a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine <=> 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38628", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA => 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628899", "l": "TP53 binds the TIGAR gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827862", "l": "SOX17 and TFAP2C bind the CBFA2T2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482857", "l": "CL transports from the ER to the IM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26025", "l": "(3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal => 8'-apo-beta-carotenol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018756", "l": "RHOH binds GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45944", "l": "12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18312", "l": "an N-acyl-D-amino acid + H2O <=> a carboxylate + a D-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36675", "l": "octacosanoyl-CoA + sphinganine = CoA + H(+) + N-(octacosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102917", "l": "(S)-reticuline 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-reticulinium(1+) + S-adenosyl-L-methionine <=> H+ + laudanine(1+) + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20166", "l": "H2O + N(5)-acyl-L-ornithine ester => an alcohol + H(+) + N(5)-acyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11869", "l": "D-arabinitol + NADP(+) => D-ribulose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68944", "l": "esculetin + S-adenosyl-L-methionine = H(+) + isoscopoletin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16560", "l": "2-amino-3-carboxymuconate 6-semialdehyde + H(+) <=> 2-aminomuconate 6-semialdehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.255", "l": "\"protein O-GlcNAc transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31517", "l": "2 H(+) + NADH + neurosporaxanthin => 4'-apo-beta-carotenal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.76", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717841", "l": "holo-FDPS dimer binds NBPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71327", "l": "chloride(out) + L-threonine(out) + 2 Na(+)(out) = chloride(in) + L-threonine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023346", "l": "MECP2 binds NOTCH1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56890", "l": "UDP-4-dehydro-beta-L-rhamnose => UDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22238", "l": "2-deoxy-D-glucose + phosphate => 2-deoxy-D-glucose 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12282", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46842", "l": "4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102334", "l": "N,N'-diacetylbacilliosaminyl-1-phosphate transferase activity", "d": ["Catalysis of the reaction: ditrans,polycis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine <=> N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71834", "l": "chloride(out) + creatine(out) + 2 Na(+)(out) <=> chloride(in) + creatine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36174", "l": "a 1-acylglycerone 3-phosphate + a long chain fatty alcohol <=> 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109857", "l": "MAP2K1 binds MAPK3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847880", "l": "CYTH proteins bind ARF1:GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34024", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) => (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75646", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45431", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514854", "l": "CDK1 phosphorylates condensin I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70425", "l": "a carboxylate + CoA + H(+) => an acyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63862", "l": "(2R,9Z,12Z)-2-hydroperoxyoctadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047090", "l": "benzoyl-CoA 3-monooxygenase activity", "d": ["Catalysis of the reaction: benzoyl-CoA + H+ + NADPH + O2 = 3-hydroxybenzoyl-CoA + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47646", "l": "4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54810", "l": "H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+) => H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001066", "l": "amylopectin binding", "d": ["Binding to amylopectin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44605", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O => a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626699", "l": "MARK4 binds ODF2 in the centriole (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31313", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+) => (2R)-3-phosphoglycerate + ADP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63561", "l": "angiotensin I + H2O => angiotensin II + L-histidyl-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59427", "l": "benzylamine + H2O + O2 <=> benzaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28438", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + tetradecanoyl-[ACP] = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696358", "l": "TREM,CD300 binds lipids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140132", "l": "iron-sulfur cluster carrier activity", "d": ["Binding to an iron-sulfur cluster and delivering it to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997237", "l": "SH2B proteins bind JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661517", "l": "LUBAC binds OTULIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10362", "l": "3-(2-hydroxyphenyl)propanoate + H(+) => 3,4-dihydrocoumarin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70433", "l": "2 H(+)(in) + Li(+)(out) => 2 H(+)(out) + Li(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052884", "l": "all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity", "d": ["Catalysis of the reaction: H2O + all-trans-retinyl palmitate = 11-cis-retinol + H+ + palmitate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70241", "l": "PCK1 phosphorylates OA to yield PEP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54827", "l": "H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] <=> alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23232", "l": "4 Fe(III)-[cytochrome c] + hydrazine = 4 Fe(II)-[cytochrome c] + 4 H(+) + N2", "d": []}, {"i": "EC:1.7.2.8", "l": "\"hydrazine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904593", "l": "prostaglandin binding", "d": ["Binding to prostaglandin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32706", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> 8-hydroxycopalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71418", "l": "3,3',5-triiodo-L-thyronine(out) + L-phenylalanine(in) <=> 3,3',5-triiodo-L-thyronine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140927", "l": "cyclic-di-GMP transmembrane transporter activity", "d": ["Enables the transfer of cyclic-di-GMP from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56419", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate <=> alpha-D-glucose 1-phosphate + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170706", "l": "Phosphorylation of  NEFL by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25847", "l": "(1S,5R)-carveol + NAD(+) <=> (R)-carvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47228", "l": "docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66686", "l": "L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein] => L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941895", "l": "Formation of CDK4/6:CCND complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28306", "l": "beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose = beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.251", "l": "\"GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol 4-beta-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450474", "l": "MK2 phosphorylates BRF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68672", "l": "16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 16alpha,17beta-estriol 16-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56247", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177692", "l": "Activation of recruited TAK1 within the activated TLR3 complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807565", "l": "GNLY is transferred to the phagosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39593", "l": "(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O => (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17839", "l": "2-carboxy-D-arabinitol + phosphate => 2-carboxy-D-arabinitol 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43552", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419033", "l": "NCAM1 binds FGFR-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358789", "l": "Self-ubiquitination of RNF41 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58776", "l": "NADP(+) + pyridine 3-methanol = H(+) + NADPH + pyridine-3-carbaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.3.-", "l": "\"Hydrolyzing S-glycosyl compounds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012835", "l": "GDIs block activation of RHOA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15100", "l": "5-formimidoyltetrahydrofolate + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789042", "l": "Hydroxyl-initiated lipid peroxidation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015434", "l": "ABC-type cadmium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd (cytosol) = ADP + phosphate + Cd (vacuole)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25367", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) = H(+) + momilactone A + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11646", "l": "an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2R,3R)-flavan-3-ol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0031856", "l": "parathyroid hormone receptor binding", "d": ["Binding to a parathyroid hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.76", "l": "\"L-iduronidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40598", "l": "dodecanedioyl-CoA + H2O <=> CoA + dodecanedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165680", "l": "Formation of active mTORC1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295516", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57124", "l": "2-oxoglutaramate = 2-hydroxy-5-oxoproline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34126", "l": "3,5,7-trioxododecanoyl-CoA <=> CoA + H(+) + olivetolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23403", "l": "7,8-dihydroxykynurenate + O2 <=> 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38452", "l": "hydrogen sulfide + NADP(+) + n sulfur => NADPH + (n+1) sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23562", "l": "adenosylcob(III)alamin 5'-phosphate + GMP + H(+) => adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749609", "l": "BCHE hydrolyzes ASA- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602050", "l": "Defective CYP26C1 does not 4-hydroxylate 9cRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9709109", "l": "DHFR dimer binds DHFR inhibitors (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783880", "l": "PIPOX oxidises PPCA to P6C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368889", "l": "Expression of NAMPT (NamPRT, PBEF, Visfatin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805061", "l": "CK2 binds FACT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0050174", "l": "phenylalanine decarboxylase activity", "d": ["Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36707", "l": "O-ureido-L-serine = O-ureido-D-serine", "d": []}, {"i": "EC:5.1.1.19", "l": "\"O-ureido-serine racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433550", "l": "palmitoyl-CoA + serine => 3-dehydrosphinganine + CoASH + CO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45210", "l": "Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193646", "l": "NGF binding to p75NTR inactivates RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619838", "l": "ARC binds DNM2 and SH3GL3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647660", "l": "GSDME (1-270) binds PIPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21958", "l": "H(+) + UDP + vitexin 2''-O-beta-D-glucoside => UDP-alpha-D-glucose + vitexin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466846", "l": "atRAL can spontaneously react with PE to form NRPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634834", "l": "ACHEIs bind ACHE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358791", "l": "Phosphorylation of USP8 by P-AKT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953111", "l": "E2F6 binds TFDP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9659611", "l": "ANO1 inhibitors bind ANO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1222491", "l": "Lactoferrin scavenges iron ions (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61112", "l": "(2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015136", "l": "sialic acid transmembrane transporter activity", "d": ["Enables the transfer of sialic acid from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.83", "l": "\"anthrax lethal factor endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74751", "l": "dodecapentaneoyl-[polyketide synthase] + fumagillol = holo-[polyketide synthase] + prefumagillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912790", "l": "CBL binds CRK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797961", "l": "CHDH oxidises Cho to BETALD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63887", "l": "H2O2 + L-tyrosine <=> H2O + L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36995", "l": "(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-481007", "l": "Exocytosis of platelet alpha granule contents (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29193", "l": "iminosuccinate + menaquinol-8 => L-aspartate + menaquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53426", "l": "an N-acyl-sphingoid base + CoA + H(+) => a fatty acyl-CoA + a sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51856", "l": "(E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out) = (2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73294", "l": "H(+)(out) + L-valine(in) <=> H(+)(in) + L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008190", "l": "eukaryotic initiation factor 4E binding", "d": ["Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43123", "l": "2-oxoglutarate + O2 + xanthine <=> CO2 + succinate + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49735", "l": "H(+) + O2 + violaceinate <=> CO2 + H2O + violacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12052", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + trichodiene", "d": []}, {"i": "EC:4.2.3.6", "l": "\"trichodiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32931", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol = a cardiolipin + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.41", "l": "\"cardiolipin synthase (CMP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23313", "l": "2 sucrose => 1(F)-beta-D-fructosylsucrose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449077", "l": "Interleukin-16 is secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39998", "l": "an N-acylethanolamine + H2O <=> a fatty acid + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.42", "l": "\"guanosine-diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703438", "l": "FLT3 fusions phosphorylate GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803892", "l": "SFN dimer binds BAX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038131", "l": "neuregulin receptor activity", "d": ["Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53824", "l": "NAD(+) + taurochenodeoxycholate = 7-oxotaurolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19299", "l": "ADP + carnosine + H(+) + phosphate => ATP + beta-alanine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12484", "l": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate", "d": []}, {"i": "EC:3.1.3.5", "l": "\"5'-nucleotidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102929", "l": "lachrymatory factor synthase activity", "d": ["Catalysis of the reaction: 1-propenylsulfenate = propanethiol S-oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5387389", "l": "Hh processing variants are translocated to the cytosol in a VCP-dependent manner (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75093", "l": "2 chloride(out) + sulfate(in) => 2 chloride(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29294", "l": "(25S)-3-oxocholest-4-en-26-oate + ATP + CoA <=> (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27283", "l": "2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174551", "l": "Formation of alternative pathway C5 convertase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399712", "l": "Activation of Ca permeable AMPA receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1878002", "l": "XYLTs transfer Xyl to core protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53378", "l": "H(+) + NADPH + uridine(16) in tRNA => 5,6-dihydrouridine(16) in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46938", "l": "ATP + H(+) + L-2-aminoadipate + NADPH => (S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693198", "l": "RHOD binds effectors at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821410", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36643", "l": "emodin + S-adenosyl-L-methionine = H(+) + questin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.283", "l": "\"emodin O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69390", "l": "allantoate + H(+) + phosphate => (S)-2-ureidoglycine + carbamoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74443", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15737", "l": "cyclopentanone + H(+) + NADPH + O2 = 5-valerolactone + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.16", "l": "\"cyclopentanone monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445064", "l": "Activation of Rac1 by VAV2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0050253", "l": "retinyl-palmitate esterase activity", "d": ["Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18859", "l": "6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lithocholate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48212", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61311", "l": "(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140692", "l": "very long-chain fatty acid omega-hydroxylase activity", "d": ["Catalysis of the reaction: an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an omega-hydroxy-very-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. A very long chain fatty acid is a fatty acid with an aliphatic tail of 22 or more carbons."]}, {"i": "RHEA:67952", "l": "an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-very-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44034", "l": "9,10-dihydroxy-(12Z)-octadecenoate => 9,10-epoxy-(12Z)-octadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29050", "l": "a menaquinone + 2 H(+)(in) + H2 <=> a menaquinol + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.2", "l": "\"ferredoxin--NADP(+) reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27428", "l": "(2E,6E)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602458", "l": "Activation of proMMP10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141341", "l": "SMOX-3 oxidises SPN to SPM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374723", "l": "Nociceptin receptor binds to nociceptin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093327", "l": "EPHA binds TIAM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8870465", "l": "RGGT binds the RAB-binding subunit (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29084", "l": "(S)-malate + ubiquinone-8 => oxaloacetate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18822", "l": "acetyl-CoA + choline => acetylcholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952371", "l": "MDM2 binds RUNX3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621411", "l": "EGR2 and SREBF2(1-484) dimer bind HMGCR gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016167", "l": "glial cell-derived neurotrophic factor receptor activity", "d": ["Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28569", "l": "3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP <=> 6 AMP + enterobactin + 7 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66356", "l": "(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+) = (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57429", "l": "anisole + O2 + reduced [NADH--hemoprotein reductase] => formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928615", "l": "EFNBs bind SFKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.31", "l": "\"scytalidopepsin A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56807", "l": "2 cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5689000", "l": "AADAC deacetylates PHEN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30570", "l": "5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate <=> 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56414", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13617", "l": "H2O + S-methyl-5'-thioadenosine = 5-(methylsulfanyl)-D-ribose + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54402", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23206", "l": "2-O-caffeoylglucarate + L-quinate => chlorogenate + D-glucarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16311", "l": "chenodeoxycholate + taurine => H2O + taurochenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48282", "l": "ganglioside GM1 + H(+) + UDP => ganglioside GM2 + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47781", "l": "a cytidine in 25S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48712", "l": "2 Fe(2+) + 2 H(+) + H2O2 = 2 Fe(3+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5251942", "l": "Hikeshi binds HSP70s:ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23899", "l": "5-dehydro-4-deoxy-D-glucuronate <=> 3-deoxy-D-glycero-2,5-hexodiulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21333", "l": "acetyl-CoA + D-glucosamine => CoA + H(+) + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161692", "l": "15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944684", "l": "miR-205 microRNA binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39915", "l": "1-O-alkyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021357", "l": "PRKCI phosphorylates ELF3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37621", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047506", "l": "(deoxy)adenylate kinase activity", "d": ["Catalysis of the reaction: ATP + dAMP = ADP + dADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20362", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-996727", "l": "REST recruits the BHC complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975633", "l": "atROL binds to RBP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67110", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59184", "l": "2,4-diacetylphloroglucinol + H2O = 2-acetylphloroglucinol + acetate", "d": []}, {"i": "EC:3.7.1.24", "l": "\"2,4-diacetylphloroglucinol hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16756", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 <=> 3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73640", "l": "CTP(out) + ITP(in) => CTP(in) + ITP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40927", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20403", "l": "a substituted beta-amino acid => a beta-lactam + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004425", "l": "indole-3-glycerol-phosphate synthase activity", "d": ["Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12173", "l": "alpha-D-glucosamine 6-phosphate + H2O => beta-D-fructose 6-phosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39571", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72056", "l": "glycodeoxycholate(out) + 2 Na(+)(out) => glycodeoxycholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0031745", "l": "cysteinyl leukotriene receptor binding", "d": ["Binding to a cysteinyl leukotriene receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13771", "l": "dihydroxyacetone + H(+) + NADH => glycerol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38955", "l": "an N-acylsphing-4-enine 1-phosphate(in) = an N-acylsphing-4-enine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66729", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in) => ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38040", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60295", "l": "L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202203", "l": "Recruitment of PI3K to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209076", "l": "SPZ dimer bound TL dimerises at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015412", "l": "ABC-type molybdate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46224", "l": "(E)-feruloyl-CoA + H2O = (E)-ferulate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24479", "l": "H2O + maleimide <=> H(+) + maleamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.19", "l": "\"phosphorylase kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140037", "l": "sumo-dependent protein binding", "d": ["Binding to a protein upon sumoylation of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49269", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103002", "l": "16-hydroxypalmitate dehydrogenase activity", "d": ["Catalysis of the reaction: 16-hydroxypalmitate + NADP <=> H+ + 16-oxo-palmitate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14238", "l": "10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32389", "l": "dihydrocarvone + H(+) + NADH => dihydrocarveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803946", "l": "TP53 stimulates PLAGL1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675790", "l": "MTORC1 dissociates from ULK complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11241", "l": "ATP + thiamine diphosphate => ADP + thiamine triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004165", "l": "delta(3)-delta(2)-enoyl-CoA isomerase activity", "d": ["Catalysis of the reactions: a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA or a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47050", "l": "3-dehydroshikimate + a quinol => a quinone + shikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871226", "l": "RET binds GFRA1,GFRA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140769", "l": "factor VII -> factor VIIa (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61345", "l": "H2O + L-serine + O2 => 3-hydroxypyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57069", "l": "3-oxoisoapionate + ATP => 3-oxoisoapionate 4-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67108", "l": "L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052738", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a quinone or similar compound."]}, {"i": "EC:1.2.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25819", "l": "H2O + norspermine + O2 <=> 3-aminopropanal + H2O2 + norspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45538", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine => H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0072496", "l": "Pup transferase activity", "d": ["Catalysis of the transfer of Pup from one protein to another via the reaction X-Pup + Y = Y-Pup + X, where both X-Pup and Y-Pup are covalent linkages."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052821", "l": "DNA-7-methyladenine glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352059", "l": "SLC6A15-mediated amino acid uptake (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70379", "l": "3-oxosphinganine + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614614", "l": "Cysteine is degraded to serine and H2S (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35469", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+) => (6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849094", "l": "ARHGAP35 binds RASA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25970", "l": "benzil + H(+) + NADPH => (S)-benzoin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66683", "l": "ATP + coproporphyrinogen III(in) + H2O <=> ADP + coproporphyrinogen III(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29924", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626228", "l": "The distal appendage proteins recruit TTBK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46006", "l": "2-methylpropanoyl-CoA + H(+) + NADH => 2-methylpropanal + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45471", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl diphosphate <=> (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034926", "l": "pyrene-4,5-epoxide hydrolase activity", "d": ["Catalysis of the reaction: pyrene-4,5-oxide + H2O = trans-4,5-dihydroxy-4,5-dihydropyrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47348", "l": "a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46585", "l": "1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase] => 1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53749", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose => a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047456", "l": "2-methylisocitrate dehydratase activity", "d": ["Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = cis-2-methylaconitate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10378", "l": "ADP + Cu(2+)(out) + H(+) + phosphate => ATP + Cu(2+)(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32061", "l": "(R)-glycerate + D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28329", "l": "H2O + wogonin 7-O-beta-D-glucuronate <=> D-glucuronate + H(+) + wogonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42554", "l": "pseudouridine(31) in tRNA => uridine(31) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12136", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) = a (2E,4E)-dienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76112", "l": "4-methylumbelliferone beta-D-glucuronate + H2O => 4-methylumbelliferone + D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51329", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => 10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48310", "l": "(3Z)-6-oxohex-3-enoyl-CoA + formate + H(+) => 2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694522", "l": "Inner coat assembly and cargo binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869694", "l": "oxPL binds CD14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381109", "l": "IRE1 binds IRE1 forming dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35024", "l": "hydroquinone O-beta-D-glucopyranoside(out) => hydroquinone O-beta-D-glucopyranoside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16304", "l": "H2O + NAD(+) <=> ADP-D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12175", "l": "alpha-D-glucosamine 6-phosphate + H2O <=> beta-D-fructose 6-phosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419351", "l": "PAF receptor binds platelet activating factor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299484", "l": "TIMM8:TIMM13 chaperones hydrophobic proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989779", "l": "Expression of ANKRD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9609921", "l": "SGTA binds Tail-anchored protein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54256", "l": "2-oxoglutarate + L-histidyl-[protein] + O2 = (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.79", "l": "\"protein-L-histidine (3S)-3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29029", "l": "2 H(+)(out) + L-glutamate(out) => 2 H(+)(in) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26485", "l": "adenosine(37) in tRNA + dimethylallyl diphosphate <=> diphosphate + N(6)-dimethylallyladenosine(37) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70969", "l": "3-sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out) => 3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:1990188", "l": "euchromatin binding", "d": ["Binding to euchromatin, a dispersed and relatively uncompacted form of chromatin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110307", "l": "REV1 binds AP-dsDNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23496", "l": "5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate", "d": []}, {"i": "EC:2.8.3.14", "l": "\"5-hydroxypentanoate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75053", "l": "chenodeoxycholate(in) => chenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18675", "l": "ADP + H(+) + O-phospho-L-seryl-[receptor-protein] => ATP + L-seryl-[receptor-protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350058", "l": "Formation of CSL NCOR corepressor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37570", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53576", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49655", "l": "H(+) + NADH + O2 + protoviolaceinate <=> H2O + NAD(+) + violaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66088", "l": "L-kynurenine + oxaloacetate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112265", "l": "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44833", "l": "(R)-carnitine + tetradecanoyl-CoA => CoA + O-tetradecanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433418", "l": "Phosphorylation of JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69109", "l": "2-oxo-3-sulfanylpropanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23709", "l": "[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate => [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64262", "l": "CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine => (9Z,12Z)-octadecadienoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21997", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA => a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69037", "l": "5beta-androstane-3,17-dione + H(+) + NADPH => 3beta-hydroxy-5beta-androstane-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35644", "l": "a (2R)-2-hydroxycarboxylate + NAD(+) => a 2-oxocarboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50296", "l": "N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase] = 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67578", "l": "[protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine => [protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64857", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + phomopsene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404144", "l": "Parenchymal atROL translocates to HSCs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817575", "l": "ERO1B oxidizes P4HB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69635", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193700", "l": "p75NTR ICD signals to NF-kB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44689", "l": "a 2-acylglycerol + H2O => a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71392", "l": "16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) => 16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15708", "l": "2 a ubiquinone + H2O + phenylacetyl-CoA <=> 2 a ubiquinol + phenylglyoxylyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48551", "l": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O <=> [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52045", "l": "mogrol + UDP-alpha-D-glucose => H(+) + mogroside IE + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983671", "l": "OAS1 binds viral dsRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31028", "l": "2-trans-(+)-abscisate + UDP-alpha-D-glucose => beta-D-glucopyranosyl trans-(+)-abscisate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34163", "l": "hydroquinone + O2 = (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": []}, {"i": "EC:1.13.11.66", "l": "\"hydroquinone 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72747", "l": "leukotriene E4(out) = leukotriene E4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086057", "l": "voltage-gated calcium channel activity involved in bundle of His cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a bundle of His cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.15", "l": "\"malonate-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171122", "l": "LDL + LDLR => LDL:LDLR complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59921", "l": "(2E)-octenal + H2O + NAD(+) => (2E)-octenoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17628", "l": "D-lysopine + H2O + NADP(+) <=> H(+) + L-lysine + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177922", "l": "EGFR dimerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69008", "l": "2 H(+) + L-aspartate + 3 NADPH + 3 O2 = 2-nitrobutanedioate + 4 H2O + 3 NADP(+)", "d": []}, {"i": "EC:1.14.13.248", "l": "\"L-aspartate N-monooxygenase (nitrosuccinate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71536", "l": "D-glucose 6-phosphate(in) + phosphate(out) => D-glucose 6-phosphate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48045", "l": "ganglioside GM1 (d18:1(4E)/18:0) + H2O => D-galactose + ganglioside GM2 (d18:1(4E)/18:0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611839", "l": "β3-agonists bind ADRB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51054", "l": "5alpha-androst-1-ene-3,17-dione + AH2 => 5alpha-androstan-3,17-dione + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19950", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate => 7,8-dihydropteroate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982017", "l": "Active G alpha (q) binds RGS proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801109", "l": "CHM binds RGGT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17598", "l": "D-mannitol + 2 Fe(III)-[cytochrome c] => D-fructose + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46201", "l": "5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] => 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42098", "l": "AMP + diphosphate + H(+) + nebramycin 5' + phosphate => ATP + carbamoyl phosphate + H2O + tobramycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804955", "l": "ATM phosphorylates MDM2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199298", "l": "AKT phosphorylates CREB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354087", "l": "Recruitment of GRB2 to p-PTK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430158", "l": "p-SLP-76 binds VAV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16513", "l": "(S)-lactate + O2 = acetate + CO2 + H2O", "d": []}, {"i": "EC:1.13.12.4", "l": "\"lactate 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204824", "l": "Interaction of Tie2 and Ang4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102891", "l": "2'4'6'34-pentahydroxychalcone 4'-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 2',3,4,4',6'-pentahydroxychalcone <=> H+ + 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35072", "l": "4-methylphenol(in) => 4-methylphenol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102296", "l": "4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase activity", "d": ["Catalysis of the reaction: (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O <=> 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40706", "l": "(9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate <=> 1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50870", "l": "(5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate => (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9716947", "l": "ESR1 binds ESR1 agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57554", "l": "(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58977", "l": "H2O + malonaldehyde + O2 => 3-oxopropanoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706319", "l": "Active FLT3 binds to SLA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15359", "l": "demethyllactenocin + dTDP + H(+) => 5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004348", "l": "glucosylceramidase activity", "d": ["Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74642", "l": "AMP(out) + CMP-N-acetyl-beta-neuraminate(in) <=> AMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769165", "l": "NPAS4 binds PLK2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654510", "l": "FGFRL1 binds SPRED1/2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004317", "l": "(3R)-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity", "d": ["Catalysis of the reaction: (3R)-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14182", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 => (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66491", "l": "quillate + UDP-alpha-D-glucose <=> quillaic acid 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611277", "l": "P2RY12 binds P2RY12 antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34622", "l": "1-deoxypentalenate + 2-oxoglutarate + O2 <=> 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009700", "l": "IL2RB and IL2RG are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58128", "l": "A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine = AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52316", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28216", "l": "[thioredoxin]-disulfide + prostaglandin F2alpha => [thioredoxin]-dithiol + prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28774", "l": "(2E)-hexadecenoyl-CoA <=> (9Z)-hexadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19481", "l": "acetyl-CoA + succinyl-CoA = 3-oxoadipyl-CoA + CoA", "d": []}, {"i": "EC:2.3.1.174", "l": "\"3-oxoadipyl-CoA thiolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928597", "l": "EPH:EFN dimers tetramerise (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15422", "l": "a long-chain fatty acid + ATP + CoA => a long-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8979071", "l": "KDM6B binds iron (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49851", "l": "(-)-dehydrodiconiferyl acid ketone + a quinone + H2O <=> (-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45641", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22804", "l": "(6S,9R)-vomifoliol + NAD(+) = (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.221", "l": "\"vomifoliol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981892", "l": "Active G alpha (z) binds RGS proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9658253", "l": "RAS:GTP binds PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724745", "l": "PLG(20-810) binds aprotinin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693250", "l": "RHOD binds effectors at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46410", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57507", "l": "3-hydroxybutane-1,2,3-tricarboxylate <=> pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013024", "l": "RHOB binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749647", "l": "CES2 hydrolyzes ASA- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64574", "l": "(2Z,6Z)-farnesyl diphosphate + diphosphate => isopentenyl diphosphate + neryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106250", "l": "DNA-binding transcription repressor activity, RNA polymerase III-specific", "d": ["A DNA-binding transcription factor activity that represses or decreases the transcription of specific genes sets transcribed by RNA polymerase III."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190263", "l": "FGFR3b binds to FGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58402", "l": "H(+) + heptanal + NADPH => heptan-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46963", "l": "butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12116", "l": "A + H2 = AH2", "d": []}, {"i": "EC:1.12.99.6", "l": "\"hydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196929", "l": "FLAD1 phosphorylates FMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687455", "l": "HSV1 RIR1 binds RIPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70230", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA <=> (E)-2-benzylidenesuccinyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32920", "l": "H2O + methyl (indol-3-yl)acetate => (indol-3-yl)acetate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755304", "l": "MUL1 ubiquitinates UBXN7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61321", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58061", "l": "2-sulfinoacetaldehyde + H2O => acetaldehyde + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047589", "l": "5-aminovalerate transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14652", "l": "demethyllactenocin + dTDP-beta-L-mycarose <=> demethylmacrocin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684275", "l": "nsp3-4 is glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003692", "l": "left-handed Z-DNA binding", "d": ["Binding to DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649733", "l": "mature p21 RAS binds GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031825", "l": "type 1F serotonin receptor binding", "d": ["Binding to a type 1F serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474210", "l": "Collagen type III degradation by MMP14 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011748", "l": "IL9R binds JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004110", "l": "corticosteroid side-chain-isomerase activity", "d": ["Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69730", "l": "2-phenylacetate + ATP + H(+) <=> diphosphate + phenylacetyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950342", "l": "EBI3:CANX binds IL27 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28573", "l": "ATP + L-serine <=> diphosphate + L-seryl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202726", "l": "F11R dimerises (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4411373", "l": "NLK translocates to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110322", "l": "Formation of Pol zeta complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102031", "l": "4-acetamido-4,6-dideoxy-D-galactose transferase activity", "d": ["Catalysis of the reaction: dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-ditrans,polycis-undecaprenol <=> H+ + alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51599", "l": "2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36059", "l": "A + dihydrourocanate = AH2 + urocanate", "d": []}, {"i": "EC:1.3.99.33", "l": "\"urocanate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50503", "l": "acetyl-CoA + N-terminal L-alanyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73568", "l": "ITP(out) + UTP(in) => ITP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047255", "l": "galactogen 6-beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: galactogen + UDP-galactose = 1,6-beta-D-galctosylgalactogen + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65391", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O <=> a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5660665", "l": "Caspase-8 binds MALT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58821", "l": "H(+) + malonate + Na(+)(in) => acetate + CO2 + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734713", "l": "ORC6 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70478", "l": "2 S-adenosyl-L-methionine + sphing-4-enine <=> 2 H(+) + N,N-dimethylsphing-4-enine + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035877", "l": "death effector domain binding", "d": ["Binding to a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65544", "l": "ganglioside GM1 + H2O = an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63438", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+) => 1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195378", "l": "Homodimerization of VEGF proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199203", "l": "PANK1/3/4 phosphorylate PanK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784861", "l": "HSPG binds LPL dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658163", "l": "Defective SLC5A2 does not cotransport Glc and Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56991", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60267", "l": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67414", "l": "carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => alpha-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159771", "l": "Furin cleaves pro-protein C to protein C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592314", "l": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373734", "l": "Nephrin interacts with Podocin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65592", "l": "8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] = 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13610", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252133", "l": "ATP6AP1 binds V-ATPase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48672", "l": "20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1266684", "l": "IL7 binds HGF(495-728) to form PPBSF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190829", "l": "Lysosomal degradation of gap junction plaques (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784765", "l": "p-Y705-STAT3 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641229", "l": "TLE oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23061", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP => a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034854", "l": "4,4-dimethyl-3-oxopentanoate decarboxylase activity", "d": ["Catalysis of the reaction: 4,4-dimethyl-3-oxopentanoate + H+ = 3,3-dimethyl-2-butanone + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140832", "l": "L-histidine, sodium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-histidine(out) + Na+(out) = H+(out) + L-histidine(in) + Na+(in)."]}, {"i": "RHEA:71135", "l": "H(+)(in) + L-histidine(out) + Na(+)(out) = H(+)(out) + L-histidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804100", "l": "HMGB1 binds LPS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30963", "l": "7,9,9'-tri-cis-neurosporene + a quinone = 7,7',9,9'-tetra-cis-lycopene + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67122", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49308", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O = a neolactoside nLc4Cer(d18:0) + L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879910", "l": "JAK2 is phosphorylated, activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645428", "l": "ALPK1 binds ADP-heptose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195275", "l": "Phosphorylation of APC component of the destruction complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23642", "l": "CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate => 1-aminocyclopropane-1-carboxylate + L-ascorbate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43012", "l": "L-homocysteine = 2-aminobut-2-enoate + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59418", "l": "H2O2 + indole-3-acetaldehyde + NH4(+) => H2O + O2 + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39596", "l": "(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH => (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635854", "l": "GLI2,3 are degraded by the proteasome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004706", "l": "JUN kinase kinase kinase activity", "d": ["Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27504", "l": "3',5'-di-O-methyltricetin + S-adenosyl-L-methionine <=> 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71023", "l": "L-leucine(in) + L-phenylalanine(out) = L-leucine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42838", "l": "5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+) => acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180016", "l": "SUMO ligase regulator activity", "d": ["Binds to and modulates the activity of a SUMO ligase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72226", "l": "4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out) <=> 4-hydroxy-L-proline + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863472", "l": "DAB2 binds LRP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-901047", "l": "Binding of ERp57 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112510", "l": "IL6ST is tyrosine phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614460", "l": "Dimerization of procollagen type VI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641134", "l": "SMURF2 binds AXIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39890", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618107", "l": "ATP binding to HSP90 triggers conformation change (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21426", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH => 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051991", "l": "UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity", "d": ["Catalysis of the reaction: N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42540", "l": "uridine(13) in tRNA = pseudouridine(13) in tRNA", "d": []}, {"i": "EC:5.4.99.27", "l": "\"tRNA pseudouridine(13) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37703", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69804", "l": "ATP + benzoate + H(+) => benzoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46947", "l": "(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) <=> H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67457", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-481007", "l": "Exocytosis of platelet alpha granule contents (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46200", "l": "5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] = 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12373", "l": "2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O => 4-oxohex-2-enedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1369052", "l": "ABCAs mediate lipid influx (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31088", "l": "acetyl-CoA + octanoyl-CoA => 3-oxodecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30466", "l": "(2Z,6Z)-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47356", "l": "an octanoate ester + H2O = an aliphatic alcohol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66949", "l": "acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate => alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027280", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003865", "l": "3-oxo-5-alpha-steroid 4-dehydrogenase activity", "d": ["Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74926", "l": "a (3R)-3-[(carboxymethyl)amino]fatty acid + H(+) + holo-[ACP] <=> a (2E)-enoyl-[ACP] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791128", "l": "Expression of LMNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75172", "l": "Formation of RAD50:MRE11 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392263", "l": "AVP(20-28) binds AVPR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59386", "l": "3-(4-aminophenyl)pyruvate + L-glutamate => 2-oxoglutarate + 4-amino-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8963915", "l": "1,25(OH)2D binds VDR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44101", "l": "H2O + NAD(+) + octanal => 2 H(+) + NADH + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757686", "l": "SERPINA6 binds PREDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928627", "l": "EPHB phosphorylates TIAM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760965", "l": "CDH11 gene is transcribed into nascent CDH11 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9011543", "l": "DCA binds PDK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67340", "l": "malonyl-CoA + quercetin 3-O-beta-D-glucoside = CoA + quercetin 3-O-(6-O-malonyl-beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19038", "l": "an epoxide + H2O => an ethanediol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44798", "l": "H(+) + menaquinol-13 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-13 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0050542", "l": "icosanoid binding", "d": ["Binding to icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25343", "l": "H2O + urea => carbamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58094", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16181", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.82", "l": "\"3-methylquercetin 7-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30032", "l": "(S)-muconolactone => cis,cis-muconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801109", "l": "CHM binds RGGT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014456", "l": "GDIs block activation of RHOG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57999", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rh2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251944", "l": "PLCG1 binds to p-ERBB2:p-EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37357", "l": "phosphate + uridine => H2O + uridine 2'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64228", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15759", "l": "H(+) + L-aspartate 4-semialdehyde + NADH => L-homoserine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50592", "l": "13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28189", "l": "aminoacetone + H2O + O2 <=> H2O2 + methylglyoxal + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938121", "l": "SERPINB13 binds CTSK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30881", "l": "2 H(+) + NADH + propynoate => H2O + NAD(+) + prop-2-ynal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18368", "l": "(R)-malate + NAD(+) <=> CO2 + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48768", "l": "ATP + D-erythrulose = ADP + D-erythrulose 4-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.210", "l": "\"D-erythrulose 4-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40290", "l": "ATP + CoA + decanedioate <=> AMP + decanedioyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54128", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008849", "l": "enterochelin esterase activity", "d": ["Catalysis of the reaction: enterobactin + 3 H2O = 3 N-23-dihydroxybenzoyl-L-serine + 3 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27749", "l": "H(+) + L-cysteine <=> CO2 + cysteamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047491", "l": "poly(alpha-L-guluronate) lyase activity", "d": ["Catalysis of the reaction: polysaccharides containing a terminal alpha-L-guluronate group = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing a terminal a-L-guluronate group, to give oligopolysaccharides with 4-deoxy-a-L-erythro-hex-4-enuronosyl groups at their nonreducing ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727293", "l": "6 localizes to the nuclear envelope (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202164", "l": "Translocation of PDK1 to Plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198611", "l": "AKT phosphorylates IKKalpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607058", "l": "Activated protein C:PROCR binds F2R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5632652", "l": "Hh-Npp binds CDON and PTCH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047803", "l": "cysteine lyase activity", "d": ["Catalysis of the reaction: L-cysteine + sulfite = L-cysteate + sulfide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72410", "l": "H(+)(in) + Li(+)(out) <=> H(+)(out) + Li(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690494", "l": "RHOB translocates to the endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507719", "l": "p62:MEKK3 binds to TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624953", "l": "ARL13B binds INPP5E (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66500", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68965", "l": "2-hydroxyoctadecanoate + O2 => 2-oxooctadecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983158", "l": "Trimming of peptides in ER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683964", "l": "ATM phosphorylates EYA1-4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75526", "l": "acetyl-CoA + S-methyl-L-cysteine <=> CoA + H(+) + N-acetyl-S-methyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69595", "l": "CMP + inosine <=> cytidine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093327", "l": "EPHA binds TIAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168888", "l": "Alpha1-Microglobulin binds heme (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40736", "l": "(20S)-ginsenoside Rb1 + 2 H2O => 2 D-glucose + gypenoside LXXV", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12780", "l": "2-amino-4-hydroxypteridine + O2 <=> 2-amino-4,7-dihydroxypteridine + chemical entity", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987007", "l": "p-STAT1 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38799", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76466", "l": "CYP4A11 12-hydroxylates DDCX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25232", "l": "L-arabinitol + NADP(+) <=> H(+) + L-arabinose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9017491", "l": "RHOJ GEFs activate RHOJ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082356", "l": "HSF1-mediated gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37472", "l": "3-methylbutanoyl-CoA + S-adenosyl-L-methionine => CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67598", "l": "CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine => heptadecasphing-4-enine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22474", "l": "(R)-4'-phosphopantetheine + ADP + H(+) => (R)-pantetheine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848818", "l": "PTK6 phosphorylates CBL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62469", "l": "3,4-dihydroxybenzoate + ATP + H(+) => 3,4-dihydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016464", "l": "chloroplast protein-transporting ATPase activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015436", "l": "ABC-type capsular-polysaccharide transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + capsular polysaccharide(in) = ADP + phosphate + capsular polysaccharide(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209823", "l": "Tyrosine is hydroxylated to dopa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10283", "l": "1,7-dimethylxanthine + S-adenosyl-L-methionine <=> caffeine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003986", "l": "acetyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: acetyl-CoA + H2O = acetate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13881", "l": "a quinone + an aldehyde + H2O = a carboxylate + a quinol + H(+)", "d": []}, {"i": "EC:1.2.5.2", "l": "\"aldehyde dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182859", "l": "RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36684", "l": "hexadecanoyl-CoA + L-cysteinyl-[protein] => CoA + S-hexadecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928640", "l": "PAKs phosphorylate MLC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018599", "l": "2-hydroxyisobutyrate 3-monooxygenase activity", "d": ["Catalysis of the reaction: 2-hydroxyisobutyrate + 1/2 O2 = 2,3-dihydroxy-2-methyl propionate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102323", "l": "2-isopropylphenol monooxygenase activity", "d": ["Catalysis of the reaction: 2-isopropylphenol + O2 + NADH + H+ = 3-isopropylcatechol + H2O + NAD."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52029", "l": "a jasmonyl-L-amino acid + H2O => a jasmonate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35783", "l": "neamine + UDP-alpha-D-kanosamine = H(+) + kanamycin B + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47879", "l": "ganglioside GD1b + H2O <=> ganglioside GM1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033818", "l": "beta-ketoacyl-acyl-carrier-protein synthase III activity", "d": ["Catalysis of the reaction: acetyl-CoA + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CoA + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4608855", "l": "PRICKLE1 is degraded by the proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75905", "l": "ADP + H(+) + O-(D-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein] => ADP-D-glycero-beta-D-manno-heptose + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51174", "l": "5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45733", "l": "D-ribulose 5-phosphate + L-tyrosine => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215391", "l": "PRMT5 is tyrosine phosphorylated by JAK2 V617F (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186786", "l": "Autophosphorylation of PDGF beta receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17017", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30112", "l": "Fe(III)-enterobactin + H(+) + 3 H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22639", "l": "dCTP + H2O <=> dCMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627072", "l": "RHOQ binds GOPC:CFTR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75862", "l": "Fall Back to Closed Pre-initiation Complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40908", "l": "2 2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24297", "l": "(S)-dihydroorotate + H2O => H(+) + N-carbamoyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41800", "l": "acetyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57673", "l": "(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] => 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.11", "l": "\"guluronate-specific alginate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23424", "l": "alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate", "d": []}, {"i": "EC:5.4.2.10", "l": "\"phosphoglucosamine mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50402", "l": "CoA + S-octanoyl-L-cysteinyl-[PqsC protein] => L-cysteinyl-[PqsC protein] + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986446", "l": "IL26 binds IL20RA:JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56483", "l": "(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734337", "l": "NKX2-5 binds the TBX5 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220816", "l": "NOTCH2 binds CNTN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442387", "l": "ZIP8 mediates zinc influx into cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23746", "l": "3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate => 2-oxoglutarate + L-histidinol phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625421", "l": "The anterograde IFT train dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65698", "l": "a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24580", "l": "D-sorbitol 6-phosphate + H2O = D-sorbitol + phosphate", "d": []}, {"i": "EC:3.1.3.50", "l": "\"sorbitol-6-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66234", "l": "H2O2 + IC-asc-DeltaC7-CoA => IC-asc-C7-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47112", "l": "chenodeoxycholate + glycine = glycochenodeoxycholate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32533", "l": "alpha-D-mannose 1-phosphate + D-glucose => 4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30588", "l": "2-demethylmenaquinol-8 + dimethyl sulfoxide => 2-demethylmenaquinone-8 + dimethyl sulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202722", "l": "CD48 binds CD244 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42389", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl crocetin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099626", "l": "voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels", "d": ["Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45430", "l": "H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24988", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] = calcitroate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53935", "l": "O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174119", "l": "Free APC/C phosphorylated by Plk1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847534", "l": "RAB43 hydrolyses GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52386", "l": "H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate => L-glutamate + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54657", "l": "linalool => (2E)-geraniol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33438", "l": "fecosterol <=> episterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.219", "l": "\"dihydroflavanol 4-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74723", "l": "Endosome acidification (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13471", "l": "5-methylbarbiturate + AH2 + H(+) => A + H2O + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051431", "l": "corticotropin-releasing hormone receptor 2 binding", "d": ["Binding to a corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66869", "l": "3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55019", "l": "H(+) + menthone + NADPH + O2 <=> 7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70740", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60026", "l": "(R,R)-chrysanthemol + diphosphate => (R,R)-chrysanthemyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53412", "l": "(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 = (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12397", "l": "dTDP-D-galactose + H2O + 2 NADP(+) => dTDP-D-galacturonate + 3 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37193", "l": "adenosine 2'-phosphate + H(+) => 2',3'-cyclophospho-AMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16289", "l": "(1R,2S)-ephedrine + NAD(+) = (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH", "d": []}, {"i": "EC:1.5.1.18", "l": "\"(-)-ephedrine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-398185", "l": "LARG binds plexin B1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-179417", "l": "Multiubiquitination of Nek2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56263", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose <=> 4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57616", "l": "dihydro-ML-236C-[compactin nonaketide synthase] + H2O = dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047534", "l": "2-acetolactate mutase activity", "d": ["Catalysis of the reaction: 2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40139", "l": "(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53501", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21865", "l": "an S-(2-hydroxyacyl)glutathione + H2O => a 2-hydroxy carboxylate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71593", "l": "2-oxoglutarate(in) + malonate(out) => 2-oxoglutarate(out) + malonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20865", "l": "alpha,alpha-trehalose 6-phosphate + phosphate => beta-D-glucose 1-phosphate + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31139", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75892", "l": "holothin + pseudomonoyl-CoA C => CoA + pseudomonic acid C--holothin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005056", "l": "tiggrin receptor activity", "d": ["Combining with the extracellular matrix ligand tiggrin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75611", "l": "H2O + plasmodiophorol A = plasmodiophorol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191072", "l": "Synthesis of Cx43 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41674", "l": "1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22881", "l": "2-oxoglutarate + L-arogenate => L-glutamate + prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53637", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0030250", "l": "guanylate cyclase activator activity", "d": ["Binds to and increases the activity of guanylate cyclase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25027", "l": "NH4(+) + S-methyl-5'-thioinosine => H(+) + H2O + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000103", "l": "CUBN:AMN binds CBLIF:RCbl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043739", "l": "G/U mismatch-specific uracil-DNA glycosylase activity", "d": ["Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil and leaving an apyrimidinic (AP) site."]}, {"i": "EC:3.2.2.28", "l": "\"double-stranded uracil-DNA glycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56584", "l": "1,2-epoxypropane + H2O = propane-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58372", "l": "(E)-oct-2-en-1-ol + NADP(+) = (2E)-octenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68734", "l": "H(+) + H2O + hainanate A + oxidized [NADPH--hemoprotein reductase] => ganoderate DM + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2484822", "l": "Kinetochore assembly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358791", "l": "Phosphorylation of USP8 by P-AKT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60348", "l": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.362", "l": "\"[histone H4]-N-methyl-L-lysine(20) N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733545", "l": "Bile salts and acids bind ALB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9728664", "l": "GLP1R binds GLP1R agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507871", "l": "Aquaporins passively transport glycerol out of cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033739", "l": "preQ1 synthase activity", "d": ["Catalysis of the reaction: 7-aminomethyl-7-deazaguanine + 2 NADP+ = 7-cyano-7-deazaguanine + 3 H+ + 2 NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14837", "l": "glyoxylate + H2O + O2 = H(+) + H2O2 + oxalate", "d": []}, {"i": "EC:1.2.3.5", "l": "\"glyoxylate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18826", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose => [(1->6)-alpha-D-glucosyl](n+1) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19915", "l": "a 3-oxoacyl-[ACP] + H(+) + NADH => a (3R)-hydroxyacyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864577", "l": "TFAP2C translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40624", "l": "H2O + tritetradecanoylglycerol => 2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45407", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate <=> 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166869", "l": "TRAF6 binds MEKK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938773", "l": "RNF144A polyubiquitinates PRKDC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450975", "l": "isocitrate <=> citrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41469", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209114", "l": "Translation of p16INK4A mRNA is inhibited by miR-24 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74712", "l": "Dissociation of IRS-P from insulin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696807", "l": "TRNT1 polymerizes CCA at the 3' end of pre-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2106614", "l": "Duplex miRNA is loaded into Argonaute (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75262", "l": "isoorientin + O2 <=> 3'-dehydroisoorientin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44573", "l": "4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+) => 2-all-trans-heptaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70654", "l": "(9Z)-hexadecenoyl-[ACP] + L-lysyl-[protein] <=> H(+) + holo-[ACP] + N(6)-[(9Z)-hexadecenoyl]-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71716", "l": "H(+)(out) + L-leucyl-L-leucine(out) => H(+)(in) + L-leucyl-L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.151", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74882", "l": "GNAT1-GDP binds to GNB1:GNGT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15361", "l": "a dolichyl phosphate + UDP-alpha-D-xylose = a dolichyl D-xylosyl phosphate + UDP", "d": []}, {"i": "EC:2.4.2.32", "l": "\"dolichyl-phosphate D-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62249", "l": "chloroacetaldehyde + H2O + NADP(+) => chloroacetate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21737", "l": "(3S)-3,6-diaminohexanoate => (3S,5S)-3,5-diaminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16070", "l": "cytidine + H(+) + H2O => NH4(+) + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30024", "l": "L-alanine + pyridoxal 5'-phosphate => pyridoxamine 5'-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32295", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH = 2 diphosphate + NADP(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9675026", "l": "Formation of the MLL1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51368", "l": "glycine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507875", "l": "Aquaporins passively transport urea into cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10045", "l": "cyclohexanol + NAD(+) => cyclohexanone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299338", "l": "Activation of TRESK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47599", "l": "an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate <=> an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65898", "l": "glycine + H2O + kynurenate => glyoxylate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21467", "l": "2 H(+) + H2O + thiocyanate <=> carbonyl sulfide + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444202", "l": "Receptor FFAR1 binds free fatty acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031872", "l": "type 1 proteinase activated receptor binding", "d": ["Binding to a type 1 proteinase activated receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090079", "l": "GLB1 hydrolyses linker chain(2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27491", "l": "D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate => 2 D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60418", "l": "H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 => diglucosyl-enterobactin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8979071", "l": "KDM6B binds iron (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668253", "l": "Hyperactivation of factor X by FVIIIa:FIXa R384L (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36141", "l": "(2E)-hexadecenoyl-CoA + AMP + diphosphate => (E)-hexadec-2-enoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61086", "l": "(2R,3R)-dihydrokaempferol + CO2 + succinate => (2S)-naringenin + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696491", "l": "CNTF binds CNTFR complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195275", "l": "Phosphorylation of APC component of the destruction complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50436", "l": "prostaglandin H1 = prostaglandin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58463", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine <=> a monoacyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602473", "l": "Autocatalytic activation of MMP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52156", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.44", "l": "\"phenylacetaldehyde oxime monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5678327", "l": "MIOX oxidises Ins to GlcA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57397", "l": "(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine => 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68331", "l": "(R)-4'-phosphopantetheine + H2O <=> (R)-pantetheine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51168", "l": "(R)-adrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449058", "l": "Interleukin-1 family are secreted (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66134", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43785", "l": "adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.34", "l": "\"legumain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56986", "l": "(6E)-nerolidol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24520", "l": "H2O + L-saccharopine + NAD(+) = (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH", "d": []}, {"i": "EC:1.5.1.9", "l": "\"saccharopine dehydrogenase (NAD(+), L-glutamate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28279", "l": "3-sulfino-L-alanine + H2O => H(+) + L-alanine + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69445", "l": "(2E,6E)-farnesyl diphosphate => alpha-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605724", "l": "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65202", "l": "(4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O => S-(acetaldehyde)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-179417", "l": "Multiubiquitination of Nek2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61113", "l": "(2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase] => (2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9022314", "l": "HIPK2 phosphorylates MECP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050403", "l": "trans-zeatin O-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: trans-zeatin + UDP-D-glucose = O-beta-D-glucosyl-trans-zeatin + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46046", "l": "(2E)-octenoyl-CoA => (3Z)-octenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013435", "l": "RHOD auto-activates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34281", "l": "di-trans,cis-polyprenol + H(+) + NADPH => di-trans,poly-cis-dolichol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31664", "l": "2-oxoglutarate + UDP-N-acetylbacillosamine => L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56088", "l": "CMP-N-acetyl-beta-neuraminate + globoside MSGG = CMP + globoside DSGG + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674529", "l": "AAMP binds to TBXA2R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31639", "l": "mycinamicin III + S-adenosyl-L-methionine = H(+) + mycinamicin IV + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.237", "l": "\"mycinamicin III 3''-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25772", "l": "2-oxoglutarate + L-asparagine + O2 = (2S,3S)-3-hydroxyasparagine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.39", "l": "\"L-asparagine oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160915", "l": "Receptor-mediated uptake of HA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047125", "l": "delta1-piperideine-2-carboxylate reductase activity", "d": ["Catalysis of the reaction: NADP+ + L-pipecolate = NADPH + delta1-piperideine-2-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-984671", "l": "Chromokinesins form dimers (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173626", "l": "Activation of C1r (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30461", "l": "(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone => (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29834", "l": "Ni(2+)(in) <=> Ni(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44466", "l": "1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047231", "l": "pyridoxine 5'-O-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: pyridoxine + UDP-D-glucose = 5'-O-beta-D-glucosylpyridoxine + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22092", "l": "(3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin] = 15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.7.3", "l": "\"phycoerythrobilin:ferredoxin oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373724", "l": "Nephrin binds NCK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37959", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30232", "l": "H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine => (2E,6E)-farnesal + H2O2 + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45252", "l": "tetradecanoate(out) = tetradecanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0017040", "l": "N-acylsphingosine amidohydrolase activity", "d": ["Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29556", "l": "H2O + UDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75576", "l": "11-O-acetylcyathatriol + A => 11-O-acetylcyathin A3 + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10548", "l": "L-arginine + O2 = 4-guanidinobutanamide + CO2 + H2O", "d": []}, {"i": "EC:1.13.12.1", "l": "\"arginine 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14807", "l": "ADP + D-allose 6-phosphate + H(+) => ATP + D-allose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24800", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O <=> (S)-2-amino-6-oxoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029453", "l": "Phosphorylation of VAV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35663", "l": "a 1,2-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191402", "l": "Reduction of presqualene diphosphate to form squalene (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067667", "l": "IL6 binds IL6R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29977", "l": "2'-deoxycytidine(out) + H(+)(out) => 2'-deoxycytidine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13073", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O = guanosine 3',5'-bis(diphosphate) + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.40", "l": "\"guanosine-5'-triphosphate,3'-diphosphate diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052596", "l": "phenethylamine:oxygen oxidoreductase (deaminating) activity", "d": ["Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444527", "l": "FPR is a receptor for formyl peptides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63552", "l": "angiotensin-(1-7) + H2O = angiotensin-(1-5) + L-histidyl-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.8", "l": "\"benzoyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41476", "l": "an acyl-CoA + zymosterol = CoA + zymosterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53724", "l": "ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68684", "l": "3'-phosphoadenylyl sulfate + testosterone 17-O-(beta-D-glucuronate) = adenosine 3',5'-bisphosphate + H(+) + testosterone 17-O-(3-sulfo-beta-D-glucuronate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48688", "l": "H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine = D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl", "d": []}, {"i": "EC:3.4.17.13", "l": "\"muramoyltetrapeptide carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0050309", "l": "sugar-terminal-phosphatase activity", "d": ["Catalysis of the reaction: H2O + sugar phosphorylated on the terminal carbon = a sugar + phosphate."]}, {"i": "EC:3.1.3.58", "l": "\"sugar-terminal-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849102", "l": "SRMS phosphorylates PTK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47990", "l": "3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH => 2-dehydro-3-deoxy-L-galactonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168038", "l": "Collagen type XV restin release (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23852", "l": "catechol + O2 = cis,cis-muconate + 2 H(+)", "d": []}, {"i": "EC:1.13.11.1", "l": "\"catechol 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64648", "l": "(E)-coniferaldehyde + CoA + NADP(+) = (E)-feruloyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062069", "l": "GARP complex binding", "d": ["Binding to a GARP complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34797", "l": "alpha-D-ribose 1,5-bisphosphate + H(+) => alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4088130", "l": "PLK1 binds FOXM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18169", "l": "4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34255", "l": "sporulenol = (R)-tetraprenyl-beta-curcumene + H2O", "d": []}, {"i": "EC:4.2.1.137", "l": "\"sporulenol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508451", "l": "PTK2B is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450422", "l": "KSRP recruits RNA degradation activities (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682826", "l": "LGI1 binds ADAM11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0016175", "l": "superoxide-generating NAD(P)H oxidase activity", "d": ["Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047549", "l": "2-nitrophenol 2-monooxygenase activity", "d": ["Catalysis of the reaction: 2-nitrophenol + 2 H+ + 2 NADPH + O2 = catechol + H2O + 2 NADP+ + nitrite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41162", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62244", "l": "a cytidine(6-4)thymidine in DNA = a cytidine-thymine dinucleotide in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72458", "l": "fumarate(out) + 3 H(+)(out) <=> fumarate(in) + 3 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49120", "l": "H(+) + NADPH + O2 + protoviolaceinate = H2O + NADP(+) + violaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202969", "l": "Caspase mediated cleavage of beta-catenin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202443", "l": "Oligomerization of CARMA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42568", "l": "2,3-dihydroxy-p-cumate + O2 = 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392064", "l": "G alpha (z) inhibits adenylate cyclase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33640", "l": "ATP + CoA + tetracosanoate => AMP + diphosphate + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23136", "l": "a primary amine + S-adenosyl-L-methionine = a methylated primary amine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73265", "l": "apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine => genkwanin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11595", "l": "dihydromonacolin L-[lovastatin nonaketide synthase] + H2O <=> dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0035312", "l": "5'-3' DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13791", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+) => [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14318", "l": "morphine + NAD(+) => H(+) + morphinone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15468", "l": "ATP + sphinganine <=> ADP + H(+) + sphinganine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75031", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 9-hydroxy-octadecanoate = (9Z-octadecenoyl)-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19999", "l": "phosphate + pyruvate => H2O + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192851", "l": "vRNA Extension (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75401", "l": "2 H(+)(in) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(in) => 2 H(+)(out) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72207", "l": "chloride(out) + 2 hydrogencarbonate(in) = chloride(in) + 2 hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12162", "l": "3-dehydro-2-deoxy-D-gluconate + H(+) + NADH => 2-deoxy-D-gluconate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381706", "l": "GLP1R:GLP1 activates G(s) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52195", "l": "(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445072", "l": "Interaction of PAK1 with Rac1-GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22420", "l": "cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) = 2 H(+) + maleylacetate + NADH", "d": []}, {"i": "EC:1.2.1.61", "l": "\"4-hydroxymuconic-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75402", "l": "2 H(+)(out) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(out) <=> 2 H(+)(in) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35601", "l": "3-hydroxypropanal + H(+) + NADPH => NADP(+) + propane-1,3-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74723", "l": "Endosome acidification (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68038", "l": "(3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+) => (S)-cystathionine ketimine + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42778", "l": "H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine => adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40123", "l": "an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43074", "l": "erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72722", "l": "eIF2 activation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36303", "l": "a fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12051", "l": "3-oxoadipate + succinyl-CoA <=> 3-oxoadipyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0019107", "l": "myristoyltransferase activity", "d": ["Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2995376", "l": "BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52805", "l": "(2E,6E)-farnesyl diphosphate => (+)-eremophilene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70688", "l": "4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) => 4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68592", "l": "(6S)-5,6,7,8-tetrahydrofolate(out) + ATP + H2O = (6S)-5,6,7,8-tetrahydrofolate(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19297", "l": "ATP + beta-alanine + L-histidine = ADP + carnosine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61293", "l": "(R)-pantoate + NAD(+) => 2-dehydropantoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755304", "l": "MUL1 ubiquitinates UBXN7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58638", "l": "(9Z)-octadecenamide + glyoxylate => N-(9Z-octadecenoyl)-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47442", "l": "3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53223", "l": "16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018594", "l": "MECP2 binds LBR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12444", "l": "hexadecanal + NADP(+) = (2E)-hexadecenal + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.27", "l": "\"2-hexadecenal reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62799", "l": "H(+) + NADPH + O2 + 2 rubrofusarin B <=> aurasperone A + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21182", "l": "D-glucose + indole-3-acetyl-1D-myo-inositol => 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67475", "l": "H2O + succinyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12691", "l": "H(+) + mycothione + NADH => 2 mycothiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57024", "l": "apulose 4-phosphate + D-glyceraldehyde 3-phosphate = D-xylulose 5-phosphate + dihydroxyacetone phosphate", "d": []}, {"i": "EC:2.2.1.13", "l": "\"apulose-4-phosphate transketolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391372", "l": "GNRHR binds GNRH1,2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9607224", "l": "Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418091", "l": "F2R binds ARRB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873946", "l": "OTUD3 deubiquitinates PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858475", "l": "ppDVL recruits RAC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013145", "l": "RAC1 binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31560", "l": "L-galactose + NAD(+) => H(+) + L-galactono-1,4-lactone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870465", "l": "RGGT binds the RAB-binding subunit (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66423", "l": "ATP + glutathione(in) + H2O + tauroursodeoxycholate(in) <=> ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928580", "l": "SFKs phosphorylate EFNBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56736", "l": "H2O + O2 + retinal = H(+) + H2O2 + retinoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69330", "l": "5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur => (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48185", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665767", "l": "Activated FMNL3 binds G-actin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015611", "l": "ABC-type D-ribose transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-ribose(out) -> ADP + phosphate + D-ribose(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38738", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865275", "l": "PDGF-BB clevage by Furin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50190", "l": "N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33324", "l": "a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA => a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16044", "l": "[(1->3)-beta-D-glucosyl](n) + phosphate <=> [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26130", "l": "diphosphate + isopimara-7,15-diene => (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374298", "l": "Opioid receptors bind opioid peptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43349", "l": "cholesteryl (9Z-octadecenoate)(in) => cholesteryl (9Z-octadecenoate)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.48", "l": "\"uridine/cytidine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467794", "l": "Resolution of sister chromatids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42378", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16076", "l": "2,2-dialkylglycine + H(+) + pyruvate <=> CO2 + dialkyl ketone + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990407", "l": "calcitonin gene-related peptide binding", "d": ["Binding to calcitonin gene-related peptide (CGRP)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35626", "l": "D-glutamate + D-glutamine <=> gamma-D-glutamyl-D-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46578", "l": "2 H2O + NADP(+) + stigmasterol => H(+) + NADPH + O2 + sitosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40816", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O => (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30345", "l": "FADH2 + fumarate => FAD + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0016884", "l": "carbon-nitrogen ligase activity, with glutamine as amido-N-donor", "d": ["Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen."]}, {"i": "EC:6.3.5.-", "l": "\"Carbon--nitrogen ligases with glutamine as amido-N-donor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047785", "l": "cortisol sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + cortisol = adenosine 3',5'-diphosphate + cortisol 21-sulfate + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0042979", "l": "ornithine decarboxylase regulator activity", "d": ["Binds to and modulates the activity of the enzyme ornithine decarboxylase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20164", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose <=> myo-inositol + raffinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380586", "l": "loading of Serotonin in synaptic vesicles (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72577", "l": "(22R)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA => (22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13851", "l": "D-ribulose => D-arabinose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052622", "l": "ATP dimethylallyltransferase activity", "d": ["Catalysis of the reaction: delta(2)-isopentenyl diphosphate + ATP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939963", "l": "Activated AKT phosphorylates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026916", "l": "GGT hydrolyses RCTR2 to RCTR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28035", "l": "[thioredoxin]-disulfide + dADP + H2O => [thioredoxin]-dithiol + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391941", "l": "BLT receptors can bind LTB4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416929", "l": "PTGFR binds PGF2a (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36360", "l": "2 a plastoquinone + 2 H2O + 4 hnu => 2 a plastoquinol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981610", "l": "Neuroglobin binds oxygen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140761", "l": "sequestered tissue factor -> tissue factor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27524", "l": "H(+) + N-formylmaleamate => 2,5-dihydroxypyridine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626938", "l": "Beta-catenin binds SOX proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49401", "l": "H2O + validoxylamine A 7'-phosphate => phosphate + validoxylamine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12786", "l": "an alditol + NAD(+) => an aldose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018573", "l": "NOTCH3 binds activated EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75477", "l": "D-mannose(in) + n Na(+)(in) => D-mannose(out) + n Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67729", "l": "DNA(n) + dZTP => diphosphate + DNA(n)-Z", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73916", "l": "acetyl-CoA + 4 H(+) + 6 malonyl-CoA => 2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + 6 CO2 + 7 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009824", "l": "AMP dimethylallyltransferase activity", "d": ["Catalysis of the reaction: AMP + dimethylallyl diphosphate = N(6)-(dimethylallyl)adenosine 5'-phosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64058", "l": "(R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1S,2R)-ephedrine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664879", "l": "ATM:PEX5 binds ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40414", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15790", "l": "L-xylose + NADP(+) => H(+) + L-xylono-1,4-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41926", "l": "(2E)-octadecenoyl-[ACP] + H2O => (3R)-hydroxyoctadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874685", "l": "CBL binds MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38885", "l": "a fatty acyl-CoA + AMP + diphosphate => a fatty acid + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68089", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] => a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008465", "l": "glycerate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48336", "l": "a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27860", "l": "3'-GMP + H(+) => 2',3'-cyclophospho-GMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4615910", "l": "SUMOylation of PCNA with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209921", "l": "Monoiodinated tyrosine can be deiodinated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54828", "l": "dimethylamine + H(+) + NADPH + O2 = formaldehyde + H2O + methylamine + NADP(+)", "d": []}, {"i": "EC:1.14.13.238", "l": "\"dimethylamine monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30682", "l": "D-cellobiose + H2O <=> beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35087", "l": "H2O + N'-monoacetylchitobiose-6'-phosphate = D-glucosamine + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445700", "l": "Myosin Binds ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160874", "l": "HYAL1 hydrolyses (HA)50 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23527", "l": "1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol <=> an alkyl cinnamate + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63446", "l": "GMP + H(+) + oxidized coenzyme F420-0 => (2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198314", "l": "DAG stimulates protein kinase C-delta (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787737", "l": "CSF3R binds CSF3 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51335", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43414", "l": "an N-acyl-sphingoid base + D-galactose => a D-galactosylceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53765", "l": "allocholate + lithocholoyl-CoA => allocholoyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034572", "l": "monodemethylisoproturon dimethylaminedehydrogenase activity", "d": ["Catalysis of the reaction: monodemethylisoproturon + H2O = didemethylisoproturon + formaldehyde + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67054", "l": "A + asnovolin A + H2O => AH2 + asnovolin J + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46742", "l": "desmosterol + NADP(+) => 7-dehydrodesmosterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42337", "l": "[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781814", "l": "USP19 deubiquitinates RNF123 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64941", "l": "dGDP + H2O => dGMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424476", "l": "Activation of RAC1 by VAV2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45650", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444527", "l": "FPR is a receptor for formyl peptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445714", "l": "Aquaporin-3 passively transports water out of cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658483", "l": "Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38892", "l": "H2O + N-hexadecanoylsphing-4-enine => hexadecanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685281", "l": "SARS-CoV-1 3a binds TRAF3 within NLRP3 inflammasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66643", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + koraiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43529", "l": "L-serine + NAD(+) => 2-aminomalonate semialdehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381727", "l": "RAP1A exchanges GDP for GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687097", "l": "p-S857 NCOA3 binds ETV4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23711", "l": "[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate <=> [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43217", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine => (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109701", "l": "PDPK1 binds PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399952", "l": "Phosphorylation of LIMK-1 by PAK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30774", "l": "guanosine + H2O <=> D-ribose + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791409", "l": "TP53 binds the CCNG1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52441", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose => a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38879", "l": "a fatty acid(in) = a fatty acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3221982", "l": "BANP binds TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56441", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66489", "l": "quillate + UDP-alpha-D-glucose => quillaic acid 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50610", "l": "12-oxo-leukotriene B4 + H(+) + NADPH => leukotriene B4 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74122", "l": "delphinidin + UDP-alpha-D-galactose <=> delphinidin 3-O-beta-D-galactoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44561", "l": "4-hydroxybenzoate + all-trans-heptaprenyl diphosphate => 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047800", "l": "cysteamine dioxygenase activity", "d": ["Catalysis of the reaction: cysteamine + O2 = H+ + hypotaurine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810076", "l": "DDO oxidizes D-Asp to OA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983078", "l": "p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66018", "l": "H2O + hypobromite => bromide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140833", "l": "RNA polymerase II CTD heptapeptide repeat Y1 kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphotyrosine (position 1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45575", "l": "[(1->4)-beta-D-mannuronosyl](n) <=> [alginate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634834", "l": "ACHEIs bind ACHE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55752", "l": "2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.8.98.6", "l": "\"formate:CoB-CoM heterodisulfide,ferredoxin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130731", "l": "Formation of COPII vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33092", "l": "1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58645", "l": "N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine => (9Z,12Z,15Z)-octadecatrienamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21472", "l": "ATP + citrate + CoA = (3S)-citryl-CoA + ADP + phosphate", "d": []}, {"i": "EC:6.2.1.18", "l": "\"citrate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60206", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17318", "l": "chlorophyllide a + H(+) + phytyl diphosphate => chlorophyll a + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759445", "l": "PREDN,PREDL diffuse into kidney cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58701", "l": "FADH2-C4alpha-hydroperoxide + NADPH + rifampicin => FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72556", "l": "estrone 3-sulfate(out) + propanoate(in) => estrone 3-sulfate(in) + propanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20586", "l": "loganin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449058", "l": "Interleukin-1 family are secreted (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662986", "l": "MT2A binds copper (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24154", "l": "3'-phosphoadenylyl sulfate + ADP + H(+) => adenosine 5'-phosphosulfate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706328", "l": "Active FLT3 binds to SOCS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28919", "l": "4-aminobutanoate(in) + L-glutamate(out) = 4-aminobutanoate(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16316", "l": "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O <=> 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24526", "l": "5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003985", "l": "acetyl-CoA C-acetyltransferase activity", "d": ["Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195304", "l": "Association of beta-catenin with the destruction complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52825", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 => (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111913", "l": "Calmodulin binds CAMK4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71648", "l": "a medium-chain (3S)-3-hydroxyacyl-CoA => a medium-chain (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24923", "l": "L-homoserine = 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30808", "l": "L-pipecolate + NAD(+) => Delta(1)-piperideine-2-carboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671873", "l": "Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76426", "l": "N-atom dealkylation of caffeine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690702", "l": "LYN phosphorylates CD22 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30657", "l": "ADP + dUDP => ATP + dUMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61429", "l": "cis-trans-nepetalactol + NAD(+) => cis-trans-nepetalactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14416", "l": "biphenyl-2,3-diol + O2 <=> 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947531", "l": "Molybdenum ion transfer onto molybdopterin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853405", "l": "TPX2 binds AURKA at centrosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450551", "l": "AUF1 binds translation and heat shock proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106375", "l": "deoxynucleoside triphosphate hydrolase activity", "d": ["Catalysis of the reaction: dNTP + H2O = 2'-deoxynucleoside + H+ + triphosphate."]}, {"i": "RHEA:46148", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48415", "l": "globoside IV3GalNAc-Gb4Cer + H2O <=> globoside Gb4Cer + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11024", "l": "ATP + NH4(+) = ADP + 2 H(+) + phosphoramidate", "d": []}, {"i": "EC:2.7.3.8", "l": "\"ammonia kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190141", "l": "ALAD binds to Pb2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48133", "l": "(2E,6E)-farnesyl phosphate + H2O => (2E,6E)-farnesol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74982", "l": "(3R)-3-isocyanylbutanoate + ATP + H(+) <=> (3R)-3-isocyanylbutanoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32012", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-T-muurolol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27837", "l": "a menaquinone + succinate <=> a menaquinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60794", "l": "3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate => 3 2-oxoglutarate + gibberellin A53 + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35120", "l": "(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O => bisdemethoxycurcumin + CO2 + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31794", "l": "H2O + tuberculosinyl diphosphate <=> (13S)-edaxadiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29984", "l": "cytidine(in) + H(+)(in) => cytidine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047205", "l": "quinate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: feruloyl-CoA + quinate = O-feruloylquinate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3318415", "l": "ATF2 acetylates histone H2B, H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647994", "l": "RAS proteins are depalmitoylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58864", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69224", "l": "a (Z)-alkenyl glucosinolate + H2O = a (Z)-N-(sulfonatooxy)alkenimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21084", "l": "chondroitin 4'-sulfate = dermatan 4'-sulfate", "d": []}, {"i": "EC:5.1.3.19", "l": "\"chondroitin-glucuronate 5-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39862", "l": "1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol <=> a triacyl-sn-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40397", "l": "H2O2 + NAD(+) => 1,2-dihydro-beta-NAD + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61327", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2327746", "l": "FN1 aggregation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53380", "l": "5,6-dihydrouridine(16) in tRNA + NAD(+) = H(+) + NADH + uridine(16) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9676254", "l": "Formation of the MLL3 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65004", "l": "ATP + decanoate + holo-[ACP] = AMP + decanoyl-[ACP] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25976", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59797", "l": "dodecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75084", "l": "32-oxo-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17987", "l": "4-(trimethylamino)butanoate + 2 H(+) + NADH => 4-(trimethylamino)butanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694733", "l": "Polyadenylation of SARS-CoV-2 subgenomic mRNAs (plus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66350", "l": "(2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2 => 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40790", "l": "H2O + tetracosanoyl-CoA <=> CoA + H(+) + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12917", "l": "3alpha(S)-strictosidine + H2O = D-glucose + strictosidine aglycone", "d": []}, {"i": "EC:3.2.1.105", "l": "\"3alpha(S)-strictosidine beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047963", "l": "glycine N-choloyltransferase activity", "d": ["Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72845", "l": "3'-dephospho-CoA(out) + ADP(in) => 3'-dephospho-CoA(in) + ADP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21767", "l": "heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693125", "l": "RHOF binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32180", "l": "(S)-2,3-dihydrodipicolinate + NAD(+) => dipicolinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41126", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189069", "l": "sucrose + H2O => glucose + fructose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805507", "l": "APAF1 binds AVEN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47005", "l": "H2O + O-phospho-L-threonyl-[protein] => L-threonyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45855", "l": "Co(II)-factor III + H(+) + S-adenosyl-L-methionine <=> Co(II)-factor IV + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63045", "l": "H2O + mevastatin => H(+) + mevinic carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56855", "l": "reumycin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + toxoflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.74", "l": "\"glucan 1,4-beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48980", "l": "3,4-dichlorocatechol + O2 = (2Z,4Z)-2,3-dichloromuconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679028", "l": "JAK3 binds JAK3 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14676", "l": "a polar amino acid(out) + ATP + H2O <=> a polar amino acid(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748996", "l": "GST dimers cleave AZA to 6MP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37305", "l": "ADP + glycyl-L-asparagine(in) + H(+) + phosphate => ATP + glycyl-L-asparagine(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19839", "l": "beta-D-fructose 6-phosphate + H(+) + NADH => D-sorbitol 6-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.-", "l": "\"With NADH or NADPH as one donor, and the other dehydrogenated\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61478", "l": "an N-octadecanoyl-sphingoid base + CoA + H(+) => a sphingoid base + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52520", "l": "O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73945", "l": "FAS-mediated dimerization of procaspase-8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381109", "l": "IRE1 binds IRE1 forming dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41786", "l": "CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)/18:0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44451", "l": "an acyl-CoA + H(+) + malonyl-[ACP] <=> a 3-oxoacyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981622", "l": "Myoglobin:oxygen dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46546", "l": "an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759189", "l": "NFE2L2-dependent PRDX1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47028", "l": "[DsrC protein]-S-sulfo-L-cysteine/L-cysteine = [DsrC protein]-disulfide + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050682", "l": "AF-2 domain binding", "d": ["Binding to an AF-2 protein domain, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68595", "l": "ORC2 binds ORC3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57981", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose => (20S)-ginsenoside F1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942302", "l": "MMP13 cleaves OPTC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-350598", "l": "Arginine<=>Agmatine+CO2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388503", "l": "Oxytocin receptor bind oxytocin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247960", "l": "Activation of p38 MAPK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13202", "l": "glycine + L-arginine => guanidinoacetate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682769", "l": "LGI2 binds ADAM22,23 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685156", "l": "ATR phosphorylates RPA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12752", "l": "3,4,5-trihydroxybenzoate + H(+) <=> 1,2,3-trihydroxybenzene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27680", "l": "ADP + dCTP => ATP + dCDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043793", "l": "beta-ribofuranosylaminobenzene 5'-phosphate synthase activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035804", "l": "structural constituent of egg coat", "d": ["The action of a molecule that contributes to the structural integrity of an egg coat. An egg coat is a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047630", "l": "ADP-phosphoglycerate phosphatase activity", "d": ["Catalysis of the reaction: 3-ADP-2-phosphoglycerate + H2O = 3-ADP-glycerate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373741", "l": "SDK2 homophillic interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56854", "l": "H(+) + S-adenosyl-L-homocysteine + toxoflavin => reumycin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13986", "l": "ATP + L-homoserine => ADP + H(+) + O-phospho-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47423", "l": "A + glutaryl-CoA <=> (2E)-glutaconyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63596", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19530", "l": "isovitexin + UDP-alpha-D-glucose => H(+) + isovitexin 2''-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13135", "l": "a dolichyl phosphate + CDP + H(+) => CTP + di-trans,poly-cis-dolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61904", "l": "betaenone A + H(+) + NADPH + O2 = H2O + NADP(+) + stemphyloxin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26066", "l": "4-O-phosphohygromycin B + ADP + H(+) => ATP + hygromycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47491", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:1903962", "l": "arachidonate transmembrane transporter activity", "d": ["Enables the transfer of arachidonate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806831", "l": "CYB5Rs reduce MetHb to HbA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.178", "l": "\"steroid 22S-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16699", "l": "AH2 + kynurenate => A + H2O + quinaldate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106586", "l": "WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847537", "l": "RAB43:GTP binds USP8NL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047020", "l": "15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10960", "l": "(S)-lactate = (R)-lactate", "d": []}, {"i": "EC:5.1.2.1", "l": "\"lactate racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27383", "l": "(2R)-2-phosphoglycerate + phosphate => (2R)-2,3-bisphosphoglycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102931", "l": "(Z,E)-alpha- farnesene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z,E)-alpha-farnesene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54792", "l": "L-histidyl-[protein] + N(7)-methyl-GTP = diphosphate + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928607", "l": "p-EPHs bind VAV2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995330", "l": "COX10 transforms heme to heme O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008759", "l": "UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity", "d": ["Catalysis of the removal of an acetyl group from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863727", "l": "STON2 is neddylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032942", "l": "inositol tetrakisphosphate 2-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol tetrakisphosphate + ATP = 1D-myo-inositol pentakisphosphate (containing 2-phosphate) + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34859", "l": "3-oxocyclopentanecarbonitrile + 2 H2O = 3-oxocyclopentanecarboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75314", "l": "D-serine(in) + L-alanine(out) + Na(+)(out) <=> D-serine(out) + L-alanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0036002", "l": "pre-mRNA binding", "d": ["Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60156", "l": "ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.5.2.11", "l": "\"ABC-type D-galactose transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5138459", "l": "WNT5A:FZD4 is endocytosed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876789", "l": "CARNMT1 methylates CARN to Anserine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821931", "l": "BOD1L1 binds SET1A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42440", "l": "L-aspartate + NAD(+) = H(+) + iminosuccinate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839091", "l": "Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373015", "l": "citrate <=> isocitrate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58666", "l": "2-oxoglutarate + a quinol => (S)-2-hydroxyglutarate + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39454", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA <=> (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170975", "l": "p-FRS2 binds CRKL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58590", "l": "(+)-vincadifformine + acetate + NADP(+) => dihydroprecondylocarpine acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16802", "l": "3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] => adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.28", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58345", "l": "beta-D-glucosyl-(1->3)-O-lithocholate + H2O => D-glucose + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28224", "l": "3-dehydro-L-gulonate 6-phosphate + ADP + H(+) => 3-dehydro-L-gulonate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61625", "l": "2-oxoglutarate + cadaverine => 5-aminopentanal + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674385", "l": "p-T,Y MAPKs dimerize (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4167501", "l": "An unknown protease degrades ACACB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15996", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 <=> 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202966", "l": "Caspase mediated cleavage of HIP-55 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199154", "l": "CD200 binds to CD200R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351208", "l": "Spermidine  => N-acetylated spermidine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74507", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B = (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75426", "l": "(R,S)-butane-2,3-diol + NAD(+) <=> (R)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669012", "l": "EDA binds EDAR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51116", "l": "guanosine(6) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.256", "l": "\"tRNA (guanine(6)-N(2))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35766", "l": "8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56379", "l": "3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 <=> 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802915", "l": "Moderate kinase activity BRAF mutants bind RAS:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22064", "l": "5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H2O", "d": []}, {"i": "EC:4.2.1.62", "l": "\"5alpha-hydroxysteroid dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21189", "l": "ATP + deamido-NAD(+) + NH4(+) => AMP + diphosphate + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2301205", "l": "SETD8 monomethylates histone H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770119", "l": "Formation of the Spliceosomal E complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18104", "l": "cis-1,2-dihydro-3-ethylcatechol + NAD(+) <=> 3-ethylcatechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71633", "l": "phosphate(out) + sulfate(in) => phosphate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395364", "l": "LTBP4 binds TGF-Beta-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433542", "l": "Phosphorylation and activation of VAV1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21419", "l": "NADP(+) + sn-glycerol 1-phosphate <=> dihydroxyacetone phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54833", "l": "a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14141", "l": "AMP + glutathione disulfide + 2 H(+) + sulfite = adenosine 5'-phosphosulfate + 2 glutathione", "d": []}, {"i": "EC:1.8.4.9", "l": "\"adenylyl-sulfate reductase (glutathione)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15217", "l": "ecdysone + hexadecanoyl-CoA = CoA + ecdysone hexadecanoate", "d": []}, {"i": "EC:2.3.1.139", "l": "\"ecdysone O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19537", "l": "D-mannitol 1-phosphate + H2O = D-mannitol + phosphate", "d": []}, {"i": "EC:3.1.3.22", "l": "\"mannitol-1-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876446", "l": "p-ULK1 phosphorylates DENND3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15185", "l": "L-arginine + succinyl-CoA = CoA + H(+) + N(2)-succinyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010356", "l": "homogentisate geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: homogentisic acid + geranylgeranyl diphosphate = 2-methyl-6-geranylgeranylplastoquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35721", "l": "(S)-versiconol + acetate + H(+) => (3S)-versiconol acetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46186", "l": "3-methylbutanoyl-CoA + AMP + diphosphate => ATP + CoA + isovalerate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52134", "l": "a 5'-end 5'-monophospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.63", "l": "\"pseudobaptigenin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39659", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201717", "l": "CSNK2-mediated phosphorylation of DVL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166038", "l": "GPI-bound CD14 binds LPS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015400", "l": "low-affinity secondary active ammonium transmembrane transporter activity", "d": ["Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047098", "l": "Latia-luciferin monooxygenase (demethylating) activity", "d": ["Catalysis of the reaction: 2 O2 + donor-H2 + Latia luciferin = light + H2O + acceptor + formate + CO2 + oxidized Latia luciferin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15756", "l": "GTP + IMP + L-aspartate <=> GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015537", "l": "xanthosine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: xanthosine(out) + H+(out) = xanthosine(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676596", "l": "TRAF3 binds BAFFR:BAFF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36786", "l": "L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73422", "l": "L-glutamine(out) <=> L-glutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40750", "l": "2-oxoglutarate + L-lysine + O2 <=> (3S)-3-hydroxy-L-lysine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73981", "l": "calarene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983422", "l": "Disassembly of COPII coated vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54854", "l": "H2O + NADP(+) + propyl butanoate => H(+) + heptan-4-one + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15980", "l": "(S)-4-hydroxymandelonitrile <=> 4-hydroxybenzaldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676264", "l": "Formation of the SET1B complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53297", "l": "(2E)-decenoyl-CoA + NADP(+) => (2E,4E)-decadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047386", "l": "fructose-2,6-bisphosphate 6-phosphatase activity", "d": ["Catalysis of the reaction: beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructofuranose 2-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41564", "l": "aklavinone + dTDP-beta-L-rhodosamine = aclacinomycin T + dTDP + 2 H(+)", "d": []}, {"i": "EC:2.4.1.326", "l": "\"aklavinone 7-L-rhodosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24418", "l": "4-hydroxybenzoate + formate + 2 H(+) => 2,4'-dihydroxyacetophenone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58588", "l": "dihydroprecondylocarpine acetate + NADPH = (+)-vincadifformine + acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706344", "l": "FLT3 phosphorylates GRB10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13401", "l": "(2E,6E)-farnesol = (2Z,6E)-farnesol", "d": []}, {"i": "EC:5.2.1.9", "l": "\"farnesol 2-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46849", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) => 5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009371", "l": "Binding of AP1 transcriptional activator complexes to CCND1 promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30894", "l": "O-acetyl-L-serine + thiosulfate <=> acetate + H(+) + S-sulfo-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47325", "l": "(S)-3-amino-3-phenylpropanoate + pyruvate => 3-oxo-3-phenylpropanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14471", "l": "(2Z,4E)-2-aminomuconate + 2 H(+) + NADH => 2-aminomuconate 6-semialdehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58676", "l": "NADPH + O2 + rifamycin SV = H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22018", "l": "arsenite + glutathionyl-S-S-[glutaredoxin] + H2O => [glutaredoxin]-dithiol + arsenate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75709", "l": "10,11-epoxy-12-hydroxy-(14Z,17Z)-eicosadienoate => 12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57281", "l": "a guanosine in RNA + glyoxal => an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-933533", "l": "Dimerization of p-IRF7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63617", "l": "prunetin + UDP-alpha-D-glucuronate => H(+) + prunetin-C(8)-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74054", "l": "D-threonine(out) + L-alanine(in) <=> D-threonine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75619", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate = ectocarpin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687107", "l": "MAPK4,6 translocate to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62582", "l": "ADP + D-cystine(in) + H(+) + phosphate => ATP + D-cystine(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37283", "l": "H2O + L-alanyl-L-histidine = L-alanine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21002", "l": "1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene => 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44390", "l": "1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236970", "l": "Proteasomal clevage of exogenous antigen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43696", "l": "H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate = diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": []}, {"i": "EC:2.7.4.27", "l": "\"([Pyruvate, phosphate dikinase] phosphate) phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662908", "l": "Dopaquinone, cysteine form CD isomers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72719", "l": "(R)-N(6)-dihydrolipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74986", "l": "Elongation of pre-rRNA transcript (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036008", "l": "Defective MAN1B1 does not hydrolyse a second 1,2-linked mannose (a branch) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67823", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18053", "l": "H2O + paraoxon = 4-nitrophenol + diethylphosphate + 2 H(+)", "d": []}, {"i": "EC:3.1.8.1", "l": "\"aryldialkylphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29002", "l": "H(+)(out) + homoserine lactone(in) <=> H(+)(in) + homoserine lactone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63005", "l": "(11Z,14Z)-eicosadienamide + H2O => (11Z,14Z)-eicosadienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28534", "l": "dTTP + H2O = diphosphate + dTMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015495", "l": "gamma-aminobutyric acid:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in)."]}, {"i": "REACT:R-HSA-428625", "l": "Vesicular inhibitory amino acid transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9627107", "l": "XIAP binds CASP7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45079", "l": "(9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] <=> (9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2169050", "l": "SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381607", "l": "Activated Adenylyl cyclase synthesizes cyclic AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0005243", "l": "gap junction channel activity", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983266", "l": "Kinesins bind microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950456", "l": "IL12B dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102984", "l": "sulfoacetaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: sulfonatoacetaldehyde + H2O + NAD <=> sulfonatoacetate + NADH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578663", "l": "MSH3 variant:MSH2-defective DNA mismatch repair (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709571", "l": "BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102463", "l": "quercetin 3-gentiobioside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-gentiobioside + UDP-L-rhamnose <=> quercetin 3-O-gentiobioside-7-O-rhamnoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863494", "l": "ASICs bind STOML3, (STOM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067659", "l": "Assembly of hexameric IL-6 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66402", "l": "ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycocholate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35359", "l": "3-hydroxyisoheptadecanoyl-CoA = (2E)-15-methylhexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604360", "l": "Initial activation of proMMP2 by MMP14 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67703", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16185", "l": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15636", "l": "3,4-dihydroxyphenylacetate + O2 <=> 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22527", "l": "2 A + a carotenoid beta-end derivative <=> a carotenoid phi-end derivative + 2 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625426", "l": "Retrograde IFT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20583", "l": "2 H(+) + hydroxylamine + NADH => H2O + NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18111", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64442", "l": "glycylglycyl-L-proline(in) + H(+)(in) => glycylglycyl-L-proline(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13518", "l": "ATP + dTMP => ADP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70899", "l": "histidine => urocanate + NH4+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047002", "l": "L-arabinitol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: L-arabinitol + NAD+ = L-ribulose + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0030548", "l": "acetylcholine receptor regulator activity", "d": ["Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728664", "l": "GLP1R binds GLP1R agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51259", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2 <=> (9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39511", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA = (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26166", "l": "4'-hydroxyechinenone + A + H2O => AH2 + echinenone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64149", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-R + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28812", "l": "2,3-dioxo-L-gulonate(in) + Na(+)(in) => 2,3-dioxo-L-gulonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140797", "l": "histone H3R17 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H3 L-arginyl (position 17)= histone H3 L-citrullyl (position 17) + NH4+, resulting in histone H3 citrullination at position 17."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67382", "l": "L-alanine + L-cysteine => H2O + L-alanyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50968", "l": "adenosine(37) in tRNA(Ala) + H(+) + H2O = inosine(37) in tRNA(Ala) + NH4(+)", "d": []}, {"i": "EC:3.5.4.34", "l": "\"tRNA(Ala)(adenine(37)) deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801415", "l": "TP53 stimulates NLRC4 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61344", "l": "H2O + L-serine + O2 = 3-hydroxypyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12900", "l": "2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030737", "l": "iodophenol O-methyltransferase activity", "d": ["Catalysis of the reaction: 2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27506", "l": "cocaine + H2O = benzoate + ecgonine methyl ester + H(+)", "d": []}, {"i": "EC:3.1.1.84", "l": "\"cocaine esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604264", "l": "ADAM10 cleaves NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373741", "l": "SDK2 homophillic interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430158", "l": "p-SLP-76 binds VAV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-994148", "l": "LRRC16A binds F-actin capping protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60750", "l": "CoA + pyrethrin II => (1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033743", "l": "peptide-methionine (R)-S-oxide reductase activity", "d": ["Catalysis of the reaction: peptide-L-methionine + H2O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624494", "l": "RAF1 binds p21 RAS:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210909", "l": "ANTXR1-bound pagA(197-794) forms oligomers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.99", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69816", "l": "cathasterone + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73538", "l": "CDP(out) + UTP(in) <=> CDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18673", "l": "ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L-seryl-[receptor-protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69576", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoadipate + H(+) = (R)-N6-(S8-glutaryldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042813", "l": "Wnt receptor activity", "d": ["Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984689", "l": "Kinesin-7 is a dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19862", "l": "a 16alpha-hydroxysteroid + NAD(+) => a 16-oxosteroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25152", "l": "2-oxoglutarate + L-phenylalanine = 3-phenylpyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55728", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31134", "l": "5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45384", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14201", "l": "D-lyxose = D-xylulose", "d": []}, {"i": "EC:5.3.1.15", "l": "\"D-lyxose ketol-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692788", "l": "JUN positively regulates MAPK6 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140760", "l": "histone H3K56me2/H3K56me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 56 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30531", "l": "biotinate sulfoxide + H(+) + NADH = biotin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390663", "l": "ADRA2A,B,C bind ADR,NAd (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70481", "l": "TPI1 isomerizes GA3P to DHAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-171122", "l": "LDL + LDLR => LDL:LDLR complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371527", "l": "HSF1 trimer translocates to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33724", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043806", "l": "keto acid formate lyase activity", "d": ["Catalysis of the reaction: 2-oxobutanoate + CoA = propionyl-CoA + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57672", "l": "(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] = 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201443", "l": "Type II receptor phosphorylates type I receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56413", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48831", "l": "H(+) + NADPH + O2 + resorcinol <=> benzene-1,2,4-triol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24275", "l": "H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 <=> H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49835", "l": "a fatty aldehyde + H2O + NAD(+) <=> a fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31455", "l": "NAD(+) + reduced riboflavin = 2 H(+) + NADH + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22893", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) => 5,10-methenyltetrahydrofolate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64548", "l": "N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] = (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602454", "l": "proMMP9 binds TIMP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008961", "l": "phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity", "d": ["Catalysis of the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine residue in an unmodified prolipoprotein."]}]}
{"type": "biolink:MolecularActivity", "ic": "78.958976004066542", "identifiers": [{"i": "GO:0008982", "l": "protein-N(PI)-phosphohistidine-sugar phosphotransferase activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}, {"i": "TCDB:4.A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49028", "l": "(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] = (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.131", "l": "\"bursehernin 5'-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052582", "l": "(+)-menthofuran synthase activity", "d": ["Catalysis of the reaction: (R)-pulegone + H+ + NADPH + O2 = (R)-menthofuran + 2 H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629372", "l": "NEIL3 recognizes and binds to thymine glycol in telomeric DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.35", "l": "\"histolysain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047809", "l": "D-2-hydroxy-acid dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-lactate + A = AH(2) + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1461982", "l": "Alpha-defensin dimers multimerize to form a pore complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41912", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADPH = hexadecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.78", "l": "\"phosphopolyprenol glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683634", "l": "Dimerisation of nucleoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334152", "l": "DNMT3A:DNMT3L methylates cytosine in DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25404", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate = (R)-3-hydroxy-3-methyl-2-oxopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62628", "l": "a hydroperoxide + H(+) + NADH = an alcohol + H2O + NAD(+)", "d": []}, {"i": "EC:1.11.1.26", "l": "\"NADH-dependent peroxiredoxin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51009", "l": "2 Fe(III)-[cytochrome cL] + methanol => 2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717841", "l": "holo-FDPS dimer binds NBPs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183067", "l": "Localization of CBL:GRB2 to the membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395320", "l": "Latent TGF-beta-1 binds integrins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042284", "l": "sphingolipid delta-4 desaturase activity", "d": ["Catalysis of the reaction: a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ -> a sphingosine ceramide (aka (4E)-sphing-4-enine ceramide) + 2 ferricytochrome b5 + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24028", "l": "2-oxoglutarate + 4-(trimethylamino)butanoate + O2 = carnitine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.1", "l": "\"gamma-butyrobetaine dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33628", "l": "ATP + CoA + decanoate => AMP + decanoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050439", "l": "2-hydroxy-3-oxoadipate synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H+ = 2-hydroxy-3-oxoadipate + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050513", "l": "glycoprotein 2-beta-D-xylosyltransferase activity", "d": ["Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + UDP-alpha-D-xylose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20096", "l": "an anthocyanidin + H(+) + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73076", "l": "luteolin + S-adenosyl-L-methionine => H(+) + luteolin 7-methyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62463", "l": "3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] <=> 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54565", "l": "a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O => a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60249", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] => AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391211", "l": "Trace amine-associated receptors can bind trace amines (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010472", "l": "GDP-galactose:glucose-1-phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: GDP-beta-L-galactose + alpha-D-glucose 1-phosphate = beta-L-galactose-1-phosphate + GDP-alpha-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028263", "l": "PGJ3 isomerises to δ12-PGJ3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635868", "l": "ub-GLI is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46052", "l": "a 3'-end uridylyl-uridine-RNA = a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093329", "l": "EFNBs bind SDCBP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17854", "l": "keto-L-sorbose + O2 => 5-dehydro-D-fructose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047938", "l": "glucose-6-phosphate 1-epimerase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707659", "l": "Hemes:LY96 activates TLR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72722", "l": "eIF2 activation (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668395", "l": "CHMP7 binds CC2D1B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56149", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphocholine => CoA + hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53840", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADP(+) = 7,12-dioxo-lithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26266", "l": "dehydroabietadienal + H2O + NADP(+) => dehydroabietate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983153", "l": "E1 mediated ubiquitin activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696271", "l": "RND1 binds effectors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18396", "l": "(R)-3-amino-2-methylpropanoate + pyruvate <=> 2-methyl-3-oxopropanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20293", "l": "3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56091", "l": "CMP-N-acetyl-beta-neuraminate + globoside MSGG <=> CMP + globoside DSGG + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24424", "l": "2 glutathione + L-dehydroascorbate = glutathione disulfide + L-ascorbate", "d": []}, {"i": "EC:1.8.5.1", "l": "\"glutathione dehydrogenase (ascorbate)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34297", "l": "2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP => 2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0120300", "l": "peptide lactyltransferase activity", "d": ["Catalysis of the reaction: (L-lysyl-[protein] + lactoyl-CoA = CoA + H+ + N(6)-lactoyl-L-lysyl-[protein]."]}, {"i": "RHEA:61996", "l": "L-lysyl-[protein] + lactoyl-CoA = CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801195", "l": "STEAP3 binds BNIP3L (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46232", "l": "(9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51144", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 = (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168184", "l": "Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69299", "l": "CDT1 binds geminin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47768", "l": "guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0005537", "l": "mannose binding", "d": ["Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans."]}, {"i": "REACT:R-HSA-947991", "l": "Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34117", "l": "H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine => carboxynorspermidine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67423", "l": "a glycerophospholipid + H2O <=> a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43281", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66884", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034938", "l": "pyrrole-2-carboxylate monooxygenase activity", "d": ["Catalysis of the reaction: pryrole-2-carboxylate + NADH + O2 + H+ = 5-hydroxypyrrole-2-carboxylate + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67798", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA => a ribonucleotidyl-ribonucleotide-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52936", "l": "3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O = (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14217", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61809", "l": "holo-[peptidyl-carrier protein] + L-alanyl-5'-AMP => AMP + H(+) + L-alanyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10391", "l": "GTP + oxaloacetate <=> CO2 + GDP + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877187", "l": "P2X7 mediates loss of intracellular K+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470011", "l": "Downregulation of c-Kit signaling by SOCS6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32653", "l": "erythromycin B + H(+) + S-adenosyl-L-homocysteine => erythromycin D + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22926", "l": "dUMP + NH4(+) => dCMP + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74537", "l": "4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether glycerophospholipid + 4 H(+) + 4 L-methionine => 2 AH2 + 2 archaetidylglycerol + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51801", "l": "deoxyadlupulone + dimethylallyl diphosphate => adlupulone + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24337", "l": "a carboxylate + ATP + CoA => AMP + an acyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53477", "l": "1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26178", "l": "1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+) => 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37915", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11933", "l": "2-hydroxy-2-methylpropanenitrile => acetone + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46841", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44038", "l": "12,13-dihydroxy-(9Z)-octadecenoate => 12,13-epoxy-(9Z)-octadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38311", "l": "carminomycin + S-adenosyl-L-methionine = daunorubicin + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.292", "l": "\"carminomycin 4-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15506", "l": "(S)-2-hydroxymethylglutarate + NAD(+) => 2-formylglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23614", "l": "alpha-santonin + H(+) + NADH => 1,2-dihydro-alpha-santonin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33279", "l": "L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.156", "l": "\"tryptophan N-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49986", "l": "(1R,2R)-12-hydroxyjasmonate + H2O + NADP(+) => H(+) + jasmonate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62474", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111879", "l": "PIP2 hydrolysis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57405", "l": "NAD(+) + narcotine hemiacetal => H(+) + NADH + noscapine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55124", "l": "(2E)-5-methylhexenoyl-[ACP] + H(+) + NADH = 5-methylhexanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046979", "l": "TAP2 binding", "d": ["Binding to the TAP2 subunit of TAP (transporter associated with antigen processing) protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72810", "l": "L-histidine(out) <=> L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29201", "l": "menaquinol-8 + orotate => (S)-dihydroorotate + menaquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1977959", "l": "ERBB4 forms heterodimers with EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72158", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) <=> 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59832", "l": "ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": []}, {"i": "EC:2.7.1.171", "l": "\"protein-fructosamine 3-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56119", "l": "2-all-trans-decaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39647", "l": "AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)", "d": []}, {"i": "EC:4.3.1.30", "l": "\"dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37091", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202713", "l": "CD84 homodimerises (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605591", "l": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "61.447207959071676", "identifiers": [{"i": "GO:0140097", "l": "catalytic activity, acting on DNA", "d": ["Catalytic activity that acts to modify DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43223", "l": "guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050326", "l": "taxifolin 8-monooxygenase activity", "d": ["Catalysis of the reaction: taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74947", "l": "p-MII:SAG dissociates to p-RHO and SAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4717461", "l": "PIAS1,2-2 SUMOylate PPARG with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791016", "l": "SFTPB binds itself (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52039", "l": "H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate <=> L-isoleucine + tuberonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426032", "l": "DAG is metabolized by DAGL to 2-AG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60716", "l": "(1R,3R)-chrysanthemal + H2O + NADP(+) = (1R,3R)-chrysanthemate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.35", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50128", "l": "NAD(+) + resolvin D1 = 17-oxoresolvin D1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40430", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53969", "l": "apo-[BtrI ACP] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69140", "l": "RPA binds to the Flap (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374662", "l": "Translocation of Ezrin to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71179", "l": "L-histidine(out) + L-tryptophan(in) = L-histidine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202960", "l": "Caspase mediated cleavage of C-IAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417896", "l": "P2Y6 receptor can bind to UDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11922", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + H2O => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49749", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate => CO2 + 2 H2O + NADP(+) + proviolacein", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001594", "l": "trace-amine receptor activity", "d": ["Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418553", "l": "cAMP degradation by Phosphodiesterases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932184", "l": "Expression of HIGD1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3782637", "l": "HDAC8 deacetylates histones (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64338", "l": "4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA => H(+) + 2 malonyl-CoA + nicotinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102819", "l": "bixin aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: bixin aldehyde + O2 + NAD <=> norbixin + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43656", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56328", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O = 5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43258", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390835", "l": "DRD1,5 bind DA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114354", "l": "SMAC binds XIAP:Caspase-7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67576", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164834", "l": "Enzyme-bound ATP is released (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17787", "l": "4-aminobutanoate + CO2 => H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13188", "l": "H2O + 4 porphobilinogen <=> hydroxymethylbilane + 4 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71024", "l": "L-leucine(in) + L-phenylalanine(out) => L-leucine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173542", "l": "SMURF2 ubiquitinates SMAD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139941", "l": "Binding of IP3 to IP3 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69173", "l": "Joining of adjacent Okazaki fragments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61754", "l": "H(+) + rebaudioside B + UDP => steviolbioside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47156", "l": "7alpha,25-dihydroxycholesterol + NAD(+) = 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404135", "l": "RBP4 binds atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32900", "l": "1,8-cineole + O2 + reduced [flavodoxin] => 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58206", "l": "dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11733", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B => H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16555", "l": "H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] => aldehydo-D-ribose 5-phosphate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19816", "l": "a 2-oxocarboxylate + L-asparagine <=> 2-oxosuccinamate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68056", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811427", "l": "COPI vesicle uncoating at the ER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74155", "l": "H2O + oxidized 2[4Fe-4S]-[ferredoxin] + sarcosine = formaldehyde + glycine + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30455", "l": "(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O = (-)-geosmin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74740", "l": "Binding of SHC1 to insulin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1369052", "l": "ABCAs mediate lipid influx (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673173", "l": "NBEA binds GLRB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34025", "l": "(E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH => 3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50994", "l": "thromboxane B2(in) => thromboxane B2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050459", "l": "ethanolamine-phosphate phospho-lyase activity", "d": ["Catalysis of the reaction: H2O + phosphoethanolamine = acetaldehyde + NH4 + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50791", "l": "NADP(+) + pentan-2-one <=> (E)-pent-3-en-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45675", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25654", "l": "(2S)-2-amino-3-oxobutanoate + H(+) => aminoacetone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61717", "l": "ATP + D-galactofuranose(out) + H2O => ADP + D-galactofuranose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25856", "l": "(9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44881", "l": "ATP + L-threonyl-[receptor-protein] => ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13436", "l": "2'-deoxycytidine + H(+) + H2O <=> 2'-deoxyuridine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008694", "l": "3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity", "d": ["Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014433", "l": "RHOG GEFs activate RHOG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28726", "l": "(S)-allantoin(in) + H(+)(in) <=> (S)-allantoin(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001070", "l": "starch binding", "d": ["Binding to starch."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64497", "l": "3,5,7,9,11-pentaoxododecanoyl-[ACP] => 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65419", "l": "dGMP(in) + NAD(+)(out) <=> dGMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52768", "l": "2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O = 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111264", "l": "Addition of nucleotides between position +11 and +30 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73595", "l": "CTP(out) + dUMP(in) = CTP(in) + dUMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606564", "l": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41866", "l": "decanoyl-[ACP] + NADP(+) => (2E)-decenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693644", "l": "HOXB1 maintains activation of HOXB1 chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75628", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + H2O => ectocarpin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65046", "l": "4-cyanobenzaldehyde + H(+) + NADH => 4-cyanobenzyl alcohol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061634", "l": "alpha-D-xyloside xylohydrolase", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose."]}, {"i": "EC:3.2.1.177", "l": "\"alpha-D-xyloside xylohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9732729", "l": "Activated JAK1 binds RAF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2214324", "l": "Collagen type VII dimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140823", "l": "histone H2BS36 kinase activity", "d": ["Catalysis of the reaction: histone H2B-serine (position 36) + ATP = histone H2B-phosphoserine (position 36) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 36 of histone H2B."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5651828", "l": "PARG dePARylates PARP1,PARP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51463", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamate <=> (9Z)-octadecenoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8963915", "l": "1,25(OH)2D binds VDR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22585", "l": "2 H(+) + heme b => Fe(2+) + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.22", "l": "\"NAD(+) diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71205", "l": "L-homoarginine(out) => L-homoarginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44604", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72324", "l": "3 Na(+)(out) + thiosulfate(out) => 3 Na(+)(in) + thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691154", "l": "HFE binds TFRC dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11818", "l": "beta-D-fructose 6-phosphate => alpha-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299359", "l": "Activation of TALK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679239", "l": "ULK complex translocates to the ER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31616", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine => dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110219", "l": "Cleavage of thymine by TDG glycosylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22579", "l": "an N-acyl-L-homoserine lactone + H2O <=> an N-acyl-L-homoserine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45470", "l": "(Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213201", "l": "Formation of collagen fibres (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624949", "l": "Assembly of the anterograde IFT train (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14568", "l": "(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51141", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 => (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56238", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19560", "l": "AH2 + O2 + pregna-4,9(11)-diene-3,20-dione <=> 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0035671", "l": "enone reductase activity", "d": ["Catalysis of the reaction: an enone + NADPH + H+ = a ketone + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62141", "l": "dTMP + GTP => dTDP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73353", "l": "AMP + carcinine + diphosphate + H(+) => ATP + beta-alanine + histamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5213466", "l": "RIPK3 is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938228", "l": "RUNX1:CBFB:CREBBP binds the CSF2 (GM-CSF) gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9652264", "l": "ERBB2 binds TKIs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712082", "l": "ALK fusions phosphorylate IRS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38085", "l": "1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38113", "l": "H(+) + L-glyceraldehyde + NADPH => glycerol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1964496", "l": "STING binds TRIM32 or TRIM56  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57396", "l": "(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine = 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.352", "l": "\"3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13070", "l": "ATP + ethanolamine => ADP + H(+) + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016629", "l": "12-oxophytodienoate reductase activity", "d": ["Catalysis of the reaction: 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-en-1-yl}cyclopentyl]octanoate + NADP+ = (15Z)-12-oxophyto-10,15-dienoate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965450", "l": "DAAM1 recruits PFN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35621", "l": "D-glucarate => L-idarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74604", "l": "CMP(out) + UDP-alpha-D-galactose(in) => CMP(in) + UDP-alpha-D-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448629", "l": "IL33 binds IL1RL1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.64", "l": "\"zeaxanthin 4-ketolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047017", "l": "prostaglandin-F synthase activity", "d": ["Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982778", "l": "Growth hormone binds the growth hormone receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32612", "l": "(6E)-8-hydroxygeranial + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252133", "l": "ATP6AP1 binds V-ATPase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21403", "l": "2-oxoglutarate + CoA + NADP(+) <=> CO2 + NADPH + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.-", "l": "\"Miscellaneous\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033883", "l": "pyridoxal phosphatase activity", "d": ["Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351207", "l": "Spermine  => N-acetylated spermine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54870", "l": "butanoyl-[ACP] + NAD(+) => (2E)-butenoyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665415", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27558", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66725", "l": "(S)-lactate + L-phenylalanine => H2O + N-[(S)-lactoyl]-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22850", "l": "3-oxooctanedioyl-CoA + H(+) + NADH => (3S)-hydroxyoctanedioyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856157", "l": "LAG3 (CD233) binds MHC II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731931", "l": "EDNRA binds selective ERAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655170", "l": "RCHY1 monoubiquitinates POLH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40483", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55175", "l": "2-oxoglutarate + hexanoyl-CoA + O2 <=> 2-hydroxyhexanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10726", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-6-deoxy-alpha-D-talose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24619", "l": "17beta-estradiol + NADP(+) <=> estrone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71342", "l": "chloride(out) + L-tyrosine(out) + 2 Na(+)(out) <=> chloride(in) + L-tyrosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30650", "l": "1D-myo-inositol 3-phosphate + CTP + H(+) <=> CDP-1L-myo-inositol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54977", "l": "(3S)-hydroxytetradecanoyl-CoA + H2O => (3S)-hydroxytetradecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.233323709485049", "identifiers": [{"i": "GO:0016861", "l": "intramolecular oxidoreductase activity, interconverting aldoses and ketoses", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears."]}, {"i": "EC:5.3.1.-", "l": "\"Interconverting aldoses and ketoses\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13390", "l": "glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] => (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58191", "l": "all-trans-lycopene + dimethylallyl diphosphate + H2O <=> dihydroisopentenyldehydrorhodopin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190258", "l": "FGFR2c binds to FGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63409", "l": "6-chloropyridine-2,3,5-triol + FADH2 + O2 => 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981657", "l": "IL34 dimer binds PTPRZ1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36686", "l": "hexadecanoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-hexadecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.11", "l": "\"cAMP-dependent protein kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23522", "l": "acetate + propanoyl-CoA => acetyl-CoA + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67928", "l": "a 3'-end 2',3'-cyclophospho-uridine-RNA + H2O = a 3'-end 3'-phosphouridine-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67750", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66680", "l": "ATP + coproporphyrinogen III(in) + H2O = ADP + coproporphyrinogen III(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23140", "l": "beta-nicotinamide D-ribonucleotide + H2O = D-ribose 5-phosphate + H(+) + nicotinamide", "d": []}, {"i": "EC:3.2.2.14", "l": "\"NMN nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54851", "l": "H(+) + hexan-3-one + NADPH + O2 <=> H2O + NADP(+) + propyl propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61292", "l": "(R)-pantoate + NAD(+) = 2-dehydropantoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64125", "l": "H2O + N-hexadecanoyl-L-phenylalanine => hexadecanoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71349", "l": "chloride(in) + L-lysine(in) + 2 Na(+)(in) => chloride(out) + L-lysine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31837", "l": "dTDP-3-dehydro-6-deoxy-alpha-D-galactose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429441", "l": "SYK activation by SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71766", "l": "2-oxoglutarate(out) + citrate(in) <=> 2-oxoglutarate(in) + citrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38194", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone <=> 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209925", "l": "DIT and MIT combine to form triiodothyronine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15840", "l": "L-glutamate + methylamine <=> N-methyl-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49103", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19312", "l": "2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O <=> (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51654", "l": "H(+) + keto-D-tagaturonate + NADH => D-mannonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462014", "l": "Alpha-defensins form biologically active dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427514", "l": "eNoSC deacetylates histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592297", "l": "Full activation of MMP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60327", "l": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011143", "l": "ROBO3.1 expression is stimulated by LHX2,(LHX9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.61", "l": "\"caspase-8\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266303", "l": "Spherical HDL binds C and E apolipoproteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30563", "l": "dimethylallyl diphosphate + L-tryptophan = 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": []}, {"i": "EC:2.5.1.80", "l": "\"7-dimethylallyltryptophan synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381435", "l": "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018754", "l": "GDIs bind RHOH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20459", "l": "D-arabinono-1,4-lactone + H(+) + NADH => D-arabinose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102461", "l": "kaempferol 3-sophoroside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose <=> kaempferol 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428909", "l": "Activated TP receptor binds G-protein  G13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088220", "l": "Endorepellin binds alpha2beta1 integrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5226979", "l": "ADD1:ADD2 binds DMTN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23895", "l": "3-nitropropanoate + NADP(+) <=> 3-nitroacrylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399930", "l": "Activation of PAK by Rac1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202703", "l": "CD47 binds SIRP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141159", "l": "TNF-mediated dimerization of procaspase-8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45679", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58360", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 = (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198621", "l": "AKT phosphorylates caspase-9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15399", "l": "2 chloride + formaldehyde + 2 H(+) => dichloromethane + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030342", "l": "1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429529", "l": "Thrombin binding to GP1b:IX:V (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22090", "l": "AMP + guanosine 3'-diphosphate 5'-triphosphate => ATP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.37", "l": "\"gingipain R\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59766", "l": "CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65328", "l": "A + chrodrimanin F = AH2 + chrodrimanin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019198", "l": "transmembrane receptor protein phosphatase activity", "d": ["Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31645", "l": "H(+) + mycinamicin III + S-adenosyl-L-homocysteine => mycinamicin VI + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1235037", "l": "Expression of VEGFA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39166", "l": "3-oxohexadecanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyhexadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71116", "l": "H(+) + hispidin + NADH + O2 => 3-hydroxyhispidin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53459", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27996", "l": "D-ribose + xanthine => H2O + xanthosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629918", "l": "NEIL1 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25221", "l": "H(+) + L-cysteate = CO2 + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55129", "l": "(3R)-hydroxy-5-methylhexanoyl-[ACP] => (2E)-5-methylhexenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34418", "l": "(1R,4R)-bornane-2,5-dione + FMNH2 + O2 <=> (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3139027", "l": "Maturation of HIV Virion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2889036", "l": "Translation of OCT4 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15826", "l": "AZD1979 + H2O => AZD1979 oxetane hydrolysis product + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70610", "l": "3'-phosphoadenylyl sulfate + 4-ethylphenol <=> 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252133", "l": "ATP6AP1 binds V-ATPase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75472", "l": "thiamine diphosphate(out) => thiamine diphosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983259", "l": "Kinesins move along microtubules consuming ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44912", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH = (3E)-hexenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36130", "l": "gibberellin A34 + S-adenosyl-L-methionine <=> O-methyl gibberellin A34 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.-", "l": "\"With NADH or NADPH as one donor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444171", "l": "Receptor FFAR2 binds carboxylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31723", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27962", "l": "myo-inositol + pyrroloquinoline quinone = H(+) + pyrroloquinoline quinol + scyllo-inosose", "d": []}, {"i": "EC:1.1.5.n1", "l": "\"quinoprotein inositol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047814", "l": "D-arabinokinase activity", "d": ["Catalysis of the reaction: D-arabinose + ATP = D-arabinose 5-phosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67696", "l": "H2O + hexadecanedioyl-CoA = CoA + H(+) + hexadecanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57621", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388900", "l": "Neurotensin receptors can bind neurotensins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24505", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 => 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39755", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001073", "l": "cyclodextrin binding", "d": ["Binding to cyclodextrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62865", "l": "7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine => 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444691", "l": "Prokineticin receptors bind prokineticin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382053", "l": "Translocation of PDGF from ER to Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56998", "l": "apulose => aldehydo-D-apiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9006850", "l": "IL21 receptor JAK phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748991", "l": "XDH oxidises 6MP to 6TU (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2029468", "l": "Conversion of PA into DAG by PAP-1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647977", "l": "ICMT methylates S-Farn RAS proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247844", "l": "WNT ligands traffic to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46588", "l": "calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcidiol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54140", "l": "cytidine(49) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42386", "l": "4,4'-diaponeurosporenoate + 2 H(+) + NADH => 4,4'-diaponeurosporenal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982778", "l": "Growth hormone binds the growth hormone receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46492", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60864", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693478", "l": "HTR1A binds HTR1A agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378952", "l": "Thyrotropin is a heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696491", "l": "CNTF binds CNTFR complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29092", "l": "a ubiquinone + 5 H(+)(in) + NADH => a ubiquinol + 4 H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13803", "l": "4 H(+) + 3 NADPH + sulfite => 3 H2O + hydrogen sulfide + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47700", "l": "H(+) + ketocytochalasin + NADPH + O2 = H2O + iso-precytochalasin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871227", "l": "RET binds GFRA4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28864", "l": "H(+)(out) + lactose(in) => H(+)(in) + lactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12347", "l": "(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) <=> H(+) + L-glutamyl-tRNA(Glu) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112042", "l": "Opioid binds MOR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30062", "l": "(S)-dihydroorotate + fumarate <=> orotate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30713", "l": "beta-myrcene + H2O => (S)-linalool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42630", "l": "5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(747) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509827", "l": "ITPA hydrolyses ITP to IMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050421", "l": "nitrite reductase (NO-forming) activity", "d": ["Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61461", "l": "a cytidine in RNA + S-adenosyl-L-methionine => a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57107", "l": "[(1->4)-alpha-D-galacturonosyl](n) <=> 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373747", "l": "Phosphorylation of nephrin by FYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033418", "l": "CUC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CUC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247840", "l": "WLS binds WNT ligands in the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615249", "l": "ARBs bind AGRT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770131", "l": "Formation of the Spliceosomal B* complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34803", "l": "2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA = bisdemethoxycurcumin + 2 CO2 + 3 CoA", "d": []}, {"i": "EC:2.3.1.211", "l": "\"bisdemethoxycurcumin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647746", "l": "EML4 trimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070905", "l": "serine binding", "d": ["Binding to 2-amino-3-hydroxypropanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68346", "l": "3',2'-cGAMP + 2 diphosphate => ATP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68316", "l": "1D-myo-inositol 2,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,5-triphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749215", "l": "MCM8 binds CDC6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61209", "l": "8-nitro-cGMP + L-cysteinyl-[protein] => H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23461", "l": "benzyl cetraxate + H2O => benzyl alcohol + cetraxate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43718", "l": "[glutamine synthetase]-L-tyrosine + ADP => [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112430", "l": "Formation of P-TEFb complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0032357", "l": "oxidized purine DNA binding", "d": ["Binding to a DNA region containing an oxidized purine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34911", "l": "D-methionine(in) = D-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72772", "l": "7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031625", "l": "ubiquitin protein ligase binding", "d": ["Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873929", "l": "Casein kinase II phosphorylates STARD10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804879", "l": "MDM2 ubiquitinates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28828", "l": "L-ornithine(out) + putrescine(in) => L-ornithine(in) + putrescine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40584", "l": "H2O + hexanedioyl-CoA => CoA + H(+) + hexanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59489", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate => ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21809", "l": "2,5-dioxopiperazine + H2O => glycylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57975", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006431", "l": "Expression of IFNG gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9641111", "l": "Parkin transfers Ub to misfolded proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72621", "l": "Ribosomal scanning  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10367", "l": "2-oxoglutarate + dodecanoyl-CoA + H2O <=> (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25407", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate <=> (R)-3-hydroxy-3-methyl-2-oxopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21028", "l": "acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014456", "l": "GDIs block activation of RHOG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26311", "l": "1,4-dihydroxy-2-naphthoate + CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983266", "l": "Kinesins bind microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45349", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11235", "l": "3'-phosphoadenylyl sulfate + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24067", "l": "2 5-aminolevulinate <=> H(+) + 2 H2O + porphobilinogen", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39027", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2430535", "l": "MASTL phosphorylates ENSA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63650", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001735", "l": "prenylcysteine oxidase activity", "d": ["Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9728664", "l": "GLP1R binds GLP1R agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112396", "l": "Separation of elongating transcript from template (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099579", "l": "G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential", "d": ["A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68087", "l": "GTP + L-histidyl-[RNA ligase] <=> diphosphate + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65125", "l": "benzoyl-CoA + ethanol => benzyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16365", "l": "digallate + H2O = 2 3,4,5-trihydroxybenzoate + H(+)", "d": []}, {"i": "EC:3.1.1.20", "l": "\"tannase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005011", "l": "macrophage colony-stimulating factor receptor activity", "d": ["Combining with macrophage colony-stimulating factor (M-CSF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55252", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine = 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34676", "l": "CTP + N,N-diacetyllegionaminate => CMP-N,N-diacetyllegionaminate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0016794", "l": "diphosphoric monoester hydrolase activity", "d": ["Catalysis of the hydrolysis of a diphosphoester to give a diphosphate group and a free hydroxyl group."]}, {"i": "EC:3.1.7.-", "l": "\"Diphosphoric monoester hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951442", "l": "CTNNB1:TCF7L2,LEF1 binds the CCND1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851908", "l": "Activated MET binds GAB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17541", "l": "an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2", "d": []}, {"i": "EC:1.1.3.7", "l": "\"aryl-alcohol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34570", "l": "CDP-alpha-D-paratose + NADP(+) <=> CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57280", "l": "a guanosine in RNA + glyoxal = an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39276", "l": "(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH => (15Z)-tetracosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202437", "l": "Phosphorylation of CARMA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33221", "l": "gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222237", "l": "SMYD2 methylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35101", "l": "fusidate(out) + H(+)(in) => fusidate(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052620", "l": "thymine dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + thymine + acceptor = 5-methyl-barbiturate + donor-H2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16250", "l": "alpha-D-glucose 6-phosphate => beta-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48211", "l": "H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578965", "l": "TNRC6A binds AGO2:miRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039594", "l": "endoribonuclease activity involved in viral induction of host mRNA catabolic process", "d": ["Any endoribonuclease activity that contributes to the viral-induced catabolism of host mRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390329", "l": "Dephosphorylation of AKT by PP2A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655733", "l": "Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75204", "l": "alpha,alpha-trehalose(out) + ATP + H2O => ADP + alpha,alpha-trehalose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874797", "l": "EGFR gene expression is stimulated by TFAP2C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875443", "l": "USP8 deubiquitinates LRIG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622667", "l": "BBC3 gene expression is stimulated by FOXO3,(FOXO1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.4", "l": "\"ABC-type Na(+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47493", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isodeoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617643", "l": "HOXA3 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814096", "l": "ARL1:GTP binds SCOC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380508", "l": "Translocation of NuMA to the centrosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20581", "l": "H2O + NAD(+) + NH4(+) = 2 H(+) + hydroxylamine + NADH", "d": []}, {"i": "EC:1.7.1.10", "l": "\"hydroxylamine reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69002", "l": "3-amino-2-hydroxy-4-methoxybenzoate + H(+) + S-adenosyl-L-homocysteine => 3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51104", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27807", "l": "acetoacetate + acetyl-CoA => acetate + acetoacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5227009", "l": "ABCF1 binds EIF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24601", "l": "H2O + O2 + sulfite => H2O2 + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64575", "l": "isopentenyl diphosphate + neryl diphosphate <=> (2Z,6Z)-farnesyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58761", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696605", "l": "USP12, USP26 deubiquitinate AR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.4", "l": "\"rubredoxin--NAD(P)(+) reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202692", "l": "PIP3 binds to RhoA and activates it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69509", "l": "H2O + N-acetyl-D-glucosamino-1,5-lactone => H(+) + N-acetyl-D-glucosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12992", "l": "a dolichyl beta-D-mannosyl phosphate + H2O <=> a dolichyl phosphate + D-mannose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189069", "l": "sucrose + H2O => glucose + fructose (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700149", "l": "Active ALK binds PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201611", "l": "Caspase-mediated cleavage of Rock-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42965", "l": "uridine(54/55) in tRNA => pseudouridine(54/55) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46954", "l": "2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin] => 2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674408", "l": "Regorafenib-resistant PDGFR mutants don't bind regorafenib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62565", "l": "(4S)-limonene + A + H2O => (4S)-perillyl alcohol + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48498", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50849", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624112", "l": "CEBPA binds CDK4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11319", "l": "an aliphatic aldoxime <=> a nitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004854", "l": "xanthine dehydrogenase activity", "d": ["Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17821", "l": "hydrogen cyanide + L-cysteine = 3-cyano-L-alanine + H(+) + hydrogen sulfide", "d": []}, {"i": "EC:4.4.1.9", "l": "\"L-3-cyanoalanine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805507", "l": "APAF1 binds AVEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41145", "l": "1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+) => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35387", "l": "precorrin-7 + S-adenosyl-L-methionine = 2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12623", "l": "CO2 + L-alanine => H(+) + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050368", "l": "tyrosine 2,3-aminomutase activity", "d": ["Catalysis of the reaction: L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019780", "l": "FAT10 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112436", "l": "Formation of Elongin complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140397", "l": "versiconal hemiacetal acetate esterase activity", "d": ["Catalyzes the reactions: versiconal hemiacetal acetate + H2O <=> versiconal + acetate, as well as versiconol acetate + H2O <=> versiconol + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75650", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (8R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4411383", "l": "NLK phosphorylates TCF/LEF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.40", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56212", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56242", "l": "2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein] => 1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33596", "l": "(4R)-hydroxysphinganine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799466", "l": "TP53I3 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37424", "l": "aclacinomycin N + O2 => aclacinomycin A + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47420", "l": "A + glutaryl-CoA = (2E)-glutaconyl-CoA + AH2", "d": []}, {"i": "EC:1.3.99.32", "l": "\"glutaryl-CoA dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53774", "l": "chenodeoxycholoyl-CoA + lithocholate => chenodeoxycholate + lithocholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705926", "l": "AR binds AR agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14125", "l": "2 raffinose = 1(F)-alpha-D-galactosylraffinose + sucrose", "d": []}, {"i": "EC:2.4.1.166", "l": "\"raffinose--raffinose alpha-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67683", "l": "a long-chain fatty acyl-CoA + H2O <=> a long-chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69972", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664850", "l": "ATM binds PEX5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381644", "l": "ER calcium channels open in response to activated PKA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2509827", "l": "ITPA hydrolyses ITP to IMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733314", "l": "CSF1R trans-autophosphorylates on tyrosine-561 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30740", "l": "1D-myo-inositol 3-phosphate + H2O => myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62313", "l": "salicylate + UDP-alpha-D-glucose => H(+) + salicylate 2-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047631", "l": "ADP-ribose diphosphatase activity", "d": ["Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296301", "l": "CCRL2 binds CCL19 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55016", "l": "H(+) + menthone + NADPH + O2 = 7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33370", "l": "D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-glucose 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67808", "l": "L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047641", "l": "aldose-6-phosphate reductase (NADPH) activity", "d": ["Catalysis of the reaction: D-glucitol 6-phosphate + NADP+ = D-glucose 6-phosphate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15920", "l": "an aldopyranose + NAD(+) <=> aldono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66268", "l": "CoA + nonanoyl-AMP = AMP + H(+) + nonanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444523", "l": "CXCR5 binds CXCL13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9675026", "l": "Formation of the MLL1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167128", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450088", "l": "GLUT1 tetramer binds 4xATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-156682", "l": "PLK1 phosphorylates NUDC (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29472", "l": "D-ribose 5-phosphate + H2O => D-ribose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008756", "l": "o-succinylbenzoate-CoA ligase activity", "d": ["Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69455", "l": "3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH <=> 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41593", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20306", "l": "4-hydroxybenzaldehyde + H2O + NAD(+) => 4-hydroxybenzoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0016423", "l": "tRNA (guanine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297444", "l": "Binding of cAMP to HCN channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18177", "l": "a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.44", "l": "\"trans-2-enoyl-CoA reductase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801213", "l": "TP53 stimulates TRIAP1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005049", "l": "nuclear export signal receptor activity", "d": ["Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23504", "l": "adenosylcob(III)inamide + H2O = (R)-1-aminopropan-2-ol + adenosylcob(III)yrate", "d": []}, {"i": "EC:3.5.1.90", "l": "\"adenosylcobinamide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14620", "l": "CoA + glutathione + NADP(+) <=> CoA-glutathione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682826", "l": "LGI1 binds ADAM11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57667", "l": "(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964280", "l": "Active Gq binds BTK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39992", "l": "(4R)-hydroxyeicosasphinganine + a fatty acyl-CoA => CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27695", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate => (S)-3-methyl-2-oxopentanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65003", "l": "holo-[ACP] + octanoyl-AMP <=> AMP + H(+) + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030770", "l": "demethylmacrocin O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + demethylmacrocin = S-adenosyl-L-homocysteine + H+ + macrocin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106239", "l": "9,13-epoxylabda-14-ene synthase activity", "d": ["Catalysis of the reaction:peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65822", "l": "dec-9-enoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => decanoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033915", "l": "mannan 1,2-(1,3)-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of (1->2) and (1->3) linkages in mannan, releasing mannose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48822", "l": "13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174494", "l": "Synthesis of ENV polyprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034780", "l": "glyphosate dehydrogenase activity", "d": ["Catalysis of the reaction: glyphosate + OH- = glyoxylate + aminomethylphosphonic acid + H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211968", "l": "CYP2W1 oxidises INDOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64912", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68336", "l": "(R)-4'-phosphopantetheine sulfonate + H2O = (R)-pantetheine sulfonate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.383", "l": "\"ketol-acid reductoisomerase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373075", "l": "Metabotropic glutamate receptors bind glutamate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709547", "l": "ESTG binds ESR2:chaperone complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59517", "l": "acetylsalicylate + L-lysyl-[protein] => H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168857", "l": "Binding of vRNP:M1:NEP complex to CRM1 export receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48176", "l": "decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52803", "l": "acetoacetyl-CoA + ATP + L-isoleucine <=> AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21509", "l": "all-trans-retinyl hexadecanoate + H2O => H(+) + hexadecanoate + retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59219", "l": "(indol-3-yl)acetate + H(+) <=> CO2 + skatole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19881", "l": "GTP + L-lysyl-[protein] = diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50697", "l": "calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71111", "l": "L-phenylalanine(out) + S-methylmercury-L-cysteine(in) = L-phenylalanine(in) + S-methylmercury-L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2997706", "l": "MDM2 SUMOylates TP53 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63854", "l": "(2R)-2-hydroperoxydodecanoate => dodecanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45461", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607838", "l": "Defective UNC93B1 does not bind TLR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11687", "l": "methylarsonous acid + S-adenosyl-L-methionine <=> dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40122", "l": "H2O + tetradecanoyl-CoA <=> CoA + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21727", "l": "a nitrile + 2 H2O <=> a carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786101", "l": "IL4 binds IL4R:JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58640", "l": "a 5'-end (5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine = a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617412", "l": "Expression of GLI1 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047019", "l": "indole-3-acetaldehyde reductase (NADPH) activity", "d": ["Catalysis of the reaction: indole-3-ethanol + NADP+ = (indol-3-yl)acetaldehyde + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371527", "l": "HSF1 trimer translocates to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905172", "l": "RISC complex binding", "d": ["Binding to a RISC complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24895", "l": "5-hydroxyxanthotoxin + S-adenosyl-L-methionine => isopimpinellin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60361", "l": "FMN + H(+) + oxidized coenzyme F420-0 => dehydro coenzyme F420-0 + FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35103", "l": "fusidate(in) = fusidate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74635", "l": "2-oxoglutarate + 5-dehydro-6-demethoxyfumagillol + O2 = 5-dehydro-6-demethoxy-6-hydroxyfumagillol + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.82", "l": "\"5-dehydro-6-demethoxyfumagillol dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71949", "l": "N-acetyl-L-aspartate(in) + 3 Na(+)(in) => N-acetyl-L-aspartate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9624798", "l": "LBR binds KPNB1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70706", "l": "D-cycloserine(in) + H(+)(in) <=> D-cycloserine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696457", "l": "BDH2 dehydrogenates 3HBA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18943", "l": "a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH => a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71188", "l": "3-hydroxy-L-kynurenine(out) + L-tryptophan(in) => 3-hydroxy-L-kynurenine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45925", "l": "9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53709", "l": "(2E)-decenoyl-CoA + NADP(+) => (2E,4Z)-decadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660666", "l": "CBP and p300 binds NF-kB complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31824", "l": "(2E,6E)-farnesyl diphosphate + H2O => cubebol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180007", "l": "RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 5) + H2O = RNA polymerase II large subunit + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2214351", "l": "PLK1 phosphorylates GORASP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432067", "l": "Aquaporin-4 passively transports water out of cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73414", "l": "succinate(in) + sulfate(out) <=> succinate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63811", "l": "ATP + citrate + spermidine <=> AMP + diphosphate + H(+) + N(8)-citryl-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170674", "l": "Dissociation of the Gi alpha:G olf complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16713", "l": "H2O + S-succinylglutathione = glutathione + H(+) + succinate", "d": []}, {"i": "EC:3.1.2.13", "l": "\"S-succinylglutathione hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58826", "l": "aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678998", "l": "Endosomal TLRs pass through the Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0030561", "l": "RNA 2'-O-ribose methylation guide activity", "d": ["Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48298", "l": "glycerol + H(+) + prostaglandin E2 => H2O + prostaglandin E2 1-glyceryl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41925", "l": "(3R)-hydroxyoctadecanoyl-[ACP] => (2E)-octadecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.-", "l": "\"Sulfotransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49436", "l": "cholate + deoxycholoyl-CoA = choloyl-CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004490", "l": "methylglutaconyl-CoA hydratase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2993802", "l": "HLCS biotinylates PC:Mn2+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2509838", "l": "ITPA hydrolyses dITP to dIMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195304", "l": "Association of beta-catenin with the destruction complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34742", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine <=> H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17278", "l": "6-phospho-D-gluconate => 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23658", "l": "3-carboxy-cis,cis-muconate + H(+) => 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0052601", "l": "(S)-limonene 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: (4S)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4S)-limonene-1,2-epoxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422454", "l": "Polysialylation of NCAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26138", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16410", "l": "1,2-dihydrovomilenine + NADP(+) => H(+) + NADPH + vomilenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606789", "l": "ARSB hydrolyses DS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35030", "l": "ATP + H2O + tungstate(in) <=> ADP + H(+) + phosphate + tungstate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874193", "l": "CREB3L1 translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038022", "l": "G protein-coupled olfactory receptor activity", "d": ["Combining with an odorant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18612", "l": "carbamoyl phosphate + N(2)-acetyl-L-ornithine <=> H(+) + N(2)-acetyl-L-citrulline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37914", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48870", "l": "AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide => H2O + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30532", "l": "biotinate sulfoxide + H(+) + NADH => biotin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44290", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73738", "l": "O2 + trans-resveratrol <=> 3,5-dihydroxybenzaldehyde + 4-hydroxybenzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19146", "l": "D-glucose 6-sulfate + H2O => D-glucose + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17105", "l": "malonyl-[ACP] + S-adenosyl-L-methionine = malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.197", "l": "\"malonyl-[acyl-carrier protein] O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.2.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008256", "l": "protein histidine pros-kinase activity", "d": ["Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033975", "l": "(R)-2-haloacid dehalogenase activity", "d": ["Catalysis of the reaction: (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-179417", "l": "Multiubiquitination of Nek2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977301", "l": "Histidine is decarboxylated to histamine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47413", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38275", "l": "(3R)-citramalyl-CoA = acetyl-CoA + pyruvate", "d": []}, {"i": "EC:4.1.3.46", "l": "\"(R)-citramalyl-CoA lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73052", "l": "hydrogencarbonate(in) + taurocholate(out) => hydrogencarbonate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19044", "l": "(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10242", "l": "a (2E)-enoyl-[ACP] + H(+) + NADH => a 2,3-saturated acyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72430", "l": "chloride(in) + K(+)(in) <=> chloride(out) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848077", "l": "PTK6 phosphorylates STAP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19468", "l": "NADPH + 2 nitric oxide + 2 O2 <=> H(+) + NADP(+) + 2 nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450466", "l": "AUF1:mRNA complex is destroyed (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9612219", "l": "ERBB4s80 binds to SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26233", "l": "(2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol", "d": []}, {"i": "EC:1.14.14.146", "l": "\"geranylgeraniol 18-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45659", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) <=> 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25311", "l": "glycolate + O2 = glyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40070", "l": "2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O <=> 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52384", "l": "L-glutamate + O-phospho-L-serine = H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate", "d": []}, {"i": "EC:2.5.1.140", "l": "\"N-(2-amino-2-carboxyethyl)-L-glutamate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73313", "l": "L-thyroxine sulfate(in) => L-thyroxine sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66714", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37116", "l": "sphing-4-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73417", "l": "H(+) + methyl isocyanate + viridicatin => (-)-cyclopenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50029", "l": "H2O + tetradecanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49530", "l": "(ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+) => (ethylene terephthalate)(n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71335", "l": "chloride(out) + L-tryptophan(out) + 2 Na(+)(out) = chloride(in) + L-tryptophan(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.216", "l": "\"farnesol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399952", "l": "Phosphorylation of LIMK-1 by PAK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35082", "l": "doxorubicin(in) <=> doxorubicin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64478", "l": "4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate => 4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73670", "l": "(E,E)-piperoyl-CoA + 2-methylpropan-1-amine <=> (E,E)-piperlonguminine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757688", "l": "SERPINA6 binds PREDN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793444", "l": "ITCH polyubiquitinates MLKL at K50 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5333051", "l": "RPA1 binds HSF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29518", "l": "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9671145", "l": "DKC1 binds SHQ1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.365", "l": "\"protopanaxadiol-type ginsenoside-3-O-glucoside 2''-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48390", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11000", "l": "an N-carbamoyl-D-amino acid + 2 H(+) + H2O = a D-alpha-amino acid + CO2 + NH4(+)", "d": []}, {"i": "EC:3.5.1.77", "l": "\"N-carbamoyl-D-amino-acid hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17375", "l": "all-trans-capsanthin => all-trans-antheraxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41893", "l": "(3R)-hydroxytetradecanoyl-[ACP] => (2E)-tetradecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169394", "l": "ISGylation of IRF3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57942", "l": "CO2 + 2 H2O + harderoheme III => Fe-coproporphyrin III + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12507", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) <=> 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31261", "l": "3-butynoate + 2 H(+) + NADH => but-3-ynal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57914", "l": "H(+) + L-glutaminyl-tRNA(Gln) + phosphate => 5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199014", "l": "CD96 binds PVR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22297", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate => (1R,2R,3R)-prephytoene diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70138", "l": "6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45366", "l": "(11Z)-eicosenoate + (4R)-hydroxysphinganine => H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69235", "l": "(Z)-3-hydroxypropyl glucosinolate + H2O <=> (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430135", "l": "p-SLP-76 binds ADAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52370", "l": "adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+) => 3'-phosphoadenylyl sulfate + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51257", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2 => (9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61959", "l": "1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10042", "l": "AMP + phosphate => adenosine 3',5'-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65040", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + a tri-(9Z,12Z-octadecadienoyl)-monolysocardiolipin = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70194", "l": "ATP + NAD(+) <=> 3'-NADP(+) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19021", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.40", "l": "\"glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088130", "l": "PLK1 binds FOXM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749977", "l": "UGT1A6 glucuronates ST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72420", "l": "(E)-4-coumarate + ATP + H(+) => (E)-4-coumaroyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58265", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol => an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218805", "l": "PKC autophosphorylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30736", "l": "1D-myo-inositol 4-phosphate + H2O => myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757445", "l": "ST translocates from ER lumen to cytosol of GI cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32908", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171106", "l": "LDLR:LDL complex => LDLR + LDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050400", "l": "xylitol kinase activity", "d": ["Catalysis of the reaction: ATP + xylitol = ADP + 2 H+ + xylitol 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2169046", "l": "Degradation of TGF-beta receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3204311", "l": "AOX1 oxidises PXL to PDXate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69657", "l": "beta-D-glucose + quercetin => H2O + quercetin 3-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71145", "l": "(E)-caffeoylpyruvate + CO2 + hnu => 3-hydroxyhispidin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45940", "l": "12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102828", "l": "stachyose galactinol:verbascose galactosyltransferase activity", "d": ["Catalysis of the reaction: stachyose + alpha-D-galactosyl-(1->3)-1D-myo-inositol <=> verbascose + myo-inositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60128", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34805", "l": "bisdemethoxycurcumin + 2 CO2 + 3 CoA => 2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61762", "l": "rebaudioside A + UDP => rebaudioside B + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114552", "l": "Thrombin-activated PARs activate G12/13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008840", "l": "4-hydroxy-tetrahydrodipicolinate synthase activity", "d": ["Catalysis of the reaction: pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66260", "l": "CoA + IC-asc-C7-AMP = AMP + H(+) + IC-asc-C7-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35563", "l": "H2O + N-(9Z-hexadecenoyl) ethanolamine = (9Z)-hexadecenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097259", "l": "20-aldehyde-leukotriene B4 20-monooxygenase activity", "d": ["Catalysis of the reaction: 20-oxo-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H+ + H2O + oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956639", "l": "RUNX1 binds YAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029460", "l": "PAK1 phosphorylates LIMK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47549", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oate => 3-oxochola-4,6-dien-24-oate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44426", "l": "CoA + H(+) + N-acyl-heptadecasphing-4-enine => a fatty acyl-CoA + heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011966", "l": "Estrogen-responsive KDM4B gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51887", "l": "L-proline betaine <=> D-proline betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22455", "l": "[phosphate](n+1) + n H2O <=> n H(+) + (n+1) phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617874", "l": "HOXD4 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683630", "l": "Nucleoprotein translocates to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446634", "l": "IRAK4 is activated by autophosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49259", "l": "2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] <=> 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58829", "l": "(9S,10R)-epoxy-octadecanoate + H2O => 9R,10R-dihydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047195", "l": "diacylglycerol-sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: sterol + 1,2-diacylglycerol = sterol ester + acylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58893", "l": "3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9 => adenosine 3',5'-bisphosphate + H(+) + omega-sulfo-beta-dihydromenaquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24195", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) <=> (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797554", "l": "ABP1 binds SHANK proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698932", "l": "Assembly of HCMV Procapsid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691174", "l": "RAC1 binds effectors at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901024", "l": "MAN1B1 hydrolyses 1,2-linked mannose (a branch) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46637", "l": "5beta-dihydrotestosterone + NADP(+) => H(+) + NADPH + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167085", "l": "Formation of DSIF:NELF:HIV-1 early elongation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14534", "l": "creatinine + H2O => creatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848726", "l": "PTK6 phosphorylates BCAR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114684", "l": "Phosphorylation of Syntaxin-4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13676", "l": "[protein-PII]-L-tyrosine + UTP <=> [protein-PII]-uridylyl-L-tyrosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64323", "l": "(9Z)-hexadecenoyl-CoA + cholesterol <=> cholesteryl (9Z)-hexadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51190", "l": "peroxynitrite => nitric oxide + superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086410", "l": "CDK1 phosphorylates BORA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570528", "l": "SUMOylation of XPC with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64070", "l": "1-phenyl-1,2-propanedione + H(+) + NADH => (R)-phenylacetylcarbinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64668", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004075", "l": "biotin carboxylase activity", "d": ["Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112514", "l": "JAK activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975873", "l": "IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52874", "l": "17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP => 17alpha-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16427", "l": "formate + 2 H(+) + NADH => formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482860", "l": "DLCL transports from the IM to the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687107", "l": "MAPK4,6 translocate to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429415", "l": "SYK binds to integrin alphaIIb beta3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72031", "l": "(E)-sinapyl alcohol + O2 = (E)-sinapaldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29140", "l": "2 H(+)(in) + menaquinol-8 + nitrate => 2 H(+)(out) + H2O + menaquinone-8 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54549", "l": "D-xylulose 1,5-bisphosphate + H2O => D-xylulose 5-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052665", "l": "tRNA (uracil-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methyluracil."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66827", "l": "2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30099", "l": "1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) = 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706393", "l": "RHOBTB3 binds ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48308", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O = (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)", "d": []}, {"i": "EC:4.1.2.44", "l": "\"2,3-epoxybenzoyl-CoA dihydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189406", "l": "4 PBGs bind to form HMB (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785898", "l": "IL4R binds JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626067", "l": "EEF1A1:GTP translocates from lysosomal membrane to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13318", "l": "(2R,3R)-tartrate + H(+) => (R)-glycerate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68535", "l": "(2E,6E)-farnesyl diphosphate <=> (Z)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19409", "l": "cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.159", "l": "\"7alpha-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696605", "l": "USP12, USP26 deubiquitinate AR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67890", "l": "3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190260", "l": "FGFR2b binds to FGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015152", "l": "glucose-6-phosphate transmembrane transporter activity", "d": ["Enables the transfer of glucose-6-phosphate from one side of a membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74712", "l": "5-dehydro-6-demethoxy-6-hydroxyfumagillol + S-adenosyl-L-methionine => 5-dehydrofumagillol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801675", "l": "PLK2 phosphorylates NPM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.29", "l": "\"25/26-hydroxycholesterol 7alpha-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71843", "l": "tauroursodeoxycholate(out) = tauroursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700120", "l": "PTN and MDK bind to PTPRZ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14240", "l": "10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015550", "l": "galacturonate transmembrane transporter activity", "d": ["Enables the transfer of galacturonate from one side of a membrane to the other. Galacturonate is the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58356", "l": "2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + L-arginyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39754", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57177", "l": "L-arginyl-[protein] + methylglyoxal => N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55415", "l": "[phosphate](n) + GTP <=> [phosphate](n+1) + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10047", "l": "cyclohexanol + NAD(+) <=> cyclohexanone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938887", "l": "PML binds RUNX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003850", "l": "2-deoxyglucose-6-phosphatase activity", "d": ["Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005483", "l": "soluble NSF attachment protein activity", "d": ["Binding to both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44355", "l": "ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide C + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062046", "l": "dehydropipecolic acid reductase", "d": ["Catalysis of the reaction: dehydropipecolic acid + NAD(P)H + H+ = L-pipecolic acid + NAD(P)+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58558", "l": "(16S)-deshydroxymethyl-stemmadenine + formate => 15alpha-stemmadenine intermediate II + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62500", "l": "holo-[peptidyl-carrier protein] + L-arginyl-AMP = AMP + H(+) + L-arginyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17891", "l": "acetaldehyde + NH4(+) + phosphate => H2O + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034839", "l": "menth-2-enone hydratase activity", "d": ["Catalysis of the reaction: (5R)-menth-2-enone + H2O = (5R)-3-hydroxymenthone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805792", "l": "p-S291-PHF20 translocates to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22742", "l": "ADP + D-hexose 6-phosphate + H(+) => ATP + D-hexose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031891", "l": "type 1 vasoactive intestinal polypeptide receptor binding", "d": ["Binding to a type 1 vasoactive intestinal polypeptide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72180", "l": "Cleavage of mRNA at the 3'-end (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47054", "l": "alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043712", "l": "2-hydroxyisocaproate CoA-transferase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxyisocaproate + isocaproyl-CoA = (R)-2-hydroxyisocaproyl-CoA + isocaproate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21437", "l": "[translation elongation factor 2] + ATP => [translation elongation factor 2]-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390835", "l": "DRD1,5 bind DA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69859", "l": "a uridine in 12S rRNA + S-adenosyl-L-methionine = a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51042", "l": "chromopyrrolate + H(+) + NH4(+) => indole-3-pyruvate imine dimer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5695964", "l": "ABHD14B hydrolyses PNPB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65459", "l": "2-methylbutan-1-ol + acetyl-CoA <=> 2-methylbutyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32651", "l": "erythromycin D + S-adenosyl-L-methionine = erythromycin B + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634861", "l": "NPAS4 binds ARNT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849646", "l": "SPINK5(490-624) binds KLK5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210285", "l": "Trans-homophilic interaction of PECAM-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69673", "l": "(2S)-naringenin + beta-D-glucose => (2S)-naringenin 7-O-beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165680", "l": "Formation of active mTORC1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18364", "l": "a dolichyl D-xylosyl phosphate + L-seryl-[protein] <=> 3-O-(beta-D-xylosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35720", "l": "(3S)-versiconol acetate + H2O => (S)-versiconol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20859", "l": "an N-acylsphing-4-enine + H2O <=> a fatty acid + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57071", "l": "3-oxoisoapionate + ATP <=> 3-oxoisoapionate 4-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20332", "l": "ATP + L-seryl-[low-density-lipoprotein receptor] <=> ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42680", "l": "2 hercynine + 2 L-selenocysteine + O2 = 2 H2O + 2 hercynylselenocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050281", "l": "serine-glyoxylate transaminase activity", "d": ["Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43452", "l": "2 H(+) + hexanoyl-CoA + 2 malonyl-CoA = 4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447246", "l": "IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24211", "l": "1,5-anhydro-D-mannitol + NADP(+) <=> 1,5-anhydro-D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664850", "l": "ATM binds PEX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017988", "l": "CRH gene expression is repressed by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65784", "l": "2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109700", "l": "AKT2 binds PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65014", "l": "AMP + decanoyl-[ACP] + H(+) => decanoyl-AMP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39574", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610723", "l": "GLI proteins bind SUFU (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40943", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74376", "l": "H2O2(out) => H2O2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34130", "l": "(2E)-geranyl diphosphate + olivetolate <=> cannabigerolate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76072", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46376", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.23", "l": "\"acyl-lipid (n+3)-(Z)-desaturase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.28", "l": "\"bacillolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036354", "l": "2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase activity", "d": ["Catalysis of the reaction: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a = bacteriochlorophyllide a + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24905", "l": "3',3'-c-di-GMP + H2O <=> 5'-phosphoguanylyl(3'->5')guanosine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40511", "l": "(2S)-3-sulfopropanediol + NAD(+) = (2S)-3-sulfolactaldehyde + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.373", "l": "\"sulfolactaldehyde 3-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0005343", "l": "organic acid:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in)."]}, {"i": "REACT:R-HSA-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862771", "l": "PLA2G2A binds bacterial phospholipids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483174", "l": "PE is methylated to PC by PEMT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46059", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (11E,13Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16097", "l": "acetylpyruvate + H2O = acetate + H(+) + pyruvate", "d": []}, {"i": "EC:3.7.1.6", "l": "\"acetylpyruvate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016498", "l": "neuromedin K receptor activity", "d": ["Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50899", "l": "8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O <=> (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49356", "l": "2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61394", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] => ATP + N(6)-(D-psicosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.17", "l": "\"benzylmalonyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001861", "l": "complement component C4b receptor activity", "d": ["Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22542", "l": "9-riburonosyladenine + H(+) + H2O2 => 5'-dehydroadenosine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656891", "l": "OPN1SW binds 11cRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46251", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (14Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44765", "l": "2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14393", "l": "N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.301", "l": "\"cypemycin N-terminal methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59453", "l": "a long-chain primary fatty alcohol + NADP(+) => a long-chain fatty aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41738", "l": "adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) => 3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18318", "l": "an L-alpha-amino acid => a D-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46102", "l": "cortisol + H2O + 2 oxidized [adrenodoxin] => 11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53322", "l": "alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+) => alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40849", "l": "(2E)-eicosenoyl-CoA + FADH2 => eicosanoyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37603", "l": "(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67847", "l": "a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782859", "l": "TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875183", "l": "CBL monoubiquitinates activated MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38298", "l": "(R)-2-hydroxyglutarate + A <=> 2-oxoglutarate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51079", "l": "2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate <=> 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13854", "l": "4-methylene-L-glutamate + ATP + NH4(+) => 4-methylene-L-glutamine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912394", "l": "NICD1 in complex with RBPJ (CSL) recruits MAML (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376122", "l": "DSCAM/DSCAML1 homodimerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47229", "l": "docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730899", "l": "Oligomerization of BCL10 and MALT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16705", "l": "17alpha-estradiol + NADP(+) = estrone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634861", "l": "NPAS4 binds ARNT2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72491", "l": "citrate(out) + maleate(in) = citrate(in) + maleate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0034235", "l": "GPI anchor binding", "d": ["Binding to a glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55540", "l": "40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] = 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate", "d": []}, {"i": "EC:1.18.6.2", "l": "\"vanadium-dependent nitrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9659820", "l": "RB1 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.4", "l": "\"nitrite reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71510", "l": "(+)-alpha-tocopherol(out) <=> (+)-alpha-tocopherol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39731", "l": "3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46138", "l": "2 H2O + NADP(+) + pyrrolnitrin => aminopyrrolnitrin + H(+) + NADPH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102333", "l": "stearoyl-[acp] elongase/decarboxylase activity", "d": ["Catalysis of the reaction: malonyl-CoA + 3 H+ + a stearoyl-[acp] = nonadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25996", "l": "H2O + N(1)-acetylspermine + O2 = H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18688", "l": "H(+) + NADPH + O2 + pentachlorophenol <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050182", "l": "phosphate butyryltransferase activity", "d": ["Catalysis of the reaction: butanoyl-CoA + phosphate = butanoyl phosphate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1222491", "l": "Lactoferrin scavenges iron ions (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36948", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54559", "l": "a 5'-end ribonucleotide-tRNA(His) + ATP + H(+) <=> a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40721", "l": "an S-substituted glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+) => an R-cob(III)alamin + apo-[alkylcobalamin reductase] + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950128", "l": "Interleukin-12 dissociates from Interleukin-12 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676589", "l": "RANKL,sRANKL trimer binds RANK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419232", "l": "Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69674", "l": "(2S)-naringenin 7-O-beta-D-glucoside + H2O <=> (2S)-naringenin + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71617", "l": "(S)-malate(out) + sulfate(in) => (S)-malate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033882", "l": "choloyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43985", "l": "(2E,6E)-farnesol + H(+) + NADPH + O2 => (2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54841", "l": "H(+) + NADPH + O2 + octan-3-one => H2O + NADP(+) + pentyl propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388814", "l": "Grb2 binds CD28 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662606", "l": "MT3 binds zinc (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14529", "l": "ADP + D-ribose 5-phosphate + H(+) = ADP-D-ribose + phosphate", "d": []}, {"i": "EC:2.7.7.35", "l": "\"ADP ribose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046523", "l": "S-methyl-5-thioribose-1-phosphate isomerase activity", "d": ["Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44380", "l": "a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66175", "l": "H(+)(out) + L-cystine(out) <=> H(+)(in) + L-cystine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186778", "l": "SHP2 binds to the active receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0009008", "l": "DNA-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to a DNA molecule."]}, {"i": "REACT:R-HSA-5227490", "l": "NoRC:HDAC:DNMT methylates cytosine of the rRNA genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193653", "l": "NGF homodimer binds to p75NTR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850534", "l": "PDCL promotes G-protein beta 5 folding (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424484", "l": "Phosphorylation of BTK by p-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54091", "l": "3,4-dihydroxyphenylacetate + H(+) + NADH + O2 <=> 2,4,5-trihydroxyphenylacetate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602454", "l": "proMMP9 binds TIMP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805276", "l": "CDK5 phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50709", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione => (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75958", "l": "2-oxoglutarate + O2 + thebaine <=> CO2 + formaldehyde + oripavine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30772", "l": "guanosine + H2O => D-ribose + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33151", "l": "(R)-dihydrolipoamide + acetyl-CoA = (R)-S(6)-acetyldihydrolipoamide + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19438", "l": "nicotinate + UDP-alpha-D-glucose => N-(beta-D-glucosyl)nicotinate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052831", "l": "inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate."]}, {"i": "REACT:R-HSA-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18854", "l": "NAD(+) + tartrate => 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781899", "l": "USP13 binds SIAH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158399", "l": "kallikrein binds SERPING1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44021", "l": "H2O + NAD(+) + octadecanal => 2 H(+) + NADH + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754763", "l": "SARS-CoV-2 M protein binds TUFM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429497", "l": "SLP-76 stimulates PLC gamma 2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56700", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate", "d": []}, {"i": "EC:1.14.20.11", "l": "\"3-[(Z)-2-isocyanoethenyl]-1H-indole synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654425", "l": "Activated FGFR4 binds SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65654", "l": "a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33561", "l": "a 2-acyl-sn-glycerol 3-phosphate + CoA => an acyl-CoA + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0016732", "l": "oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen."]}, {"i": "EC:1.18.6.-", "l": "\"With dinitrogen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27735", "l": "4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47779", "l": "guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73389", "l": "H(+)(out) + malonate(in) + phosphate(out) => H(+)(in) + malonate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050200", "l": "plasmalogen synthase activity", "d": ["Catalysis of the reaction: acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine = CoA + plasmenylcholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694541", "l": "SARS-CoV-2 gRNA:RTC:RNA primer binds RTC inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46536", "l": "(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.339", "l": "\"dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9817575", "l": "ERO1B oxidizes P4HB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69417", "l": "H(+) + H2O2 + thiocyanate => H2O + hypothiocyanous acid", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019960", "l": "C-X3-C chemokine binding", "d": ["Binding to a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51748", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A = 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74723", "l": "Endosome acidification (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61190", "l": "H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP => quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16875", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48919", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b <=> CMP + ganglioside GD1c + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56057", "l": "genistein + UDP-alpha-D-glucose => genistein 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53658", "l": "(5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate => (5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19503", "l": "4-aminobutanoate + urea => 4-guanidinobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12974", "l": "AMP + ATP => 2 ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001409", "l": "guanine nucleotide transmembrane transporter activity", "d": ["Enables the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047718", "l": "indanol dehydrogenase activity", "d": ["Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51402", "l": "CoA + H(+) + N-octadecanoyl-serotonin => octadecanoyl-CoA + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73806", "l": "dimethylallyl diphosphate + neoechinulin B <=> diphosphate + isoechinulin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30201", "l": "2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin] => 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29880", "l": "ATP + H2O + L-arginine(out) => ADP + H(+) + L-arginine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163310", "l": "TFAM binds to mitochondrial promoters (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54733", "l": "N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70149", "l": "28-norcastasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-norcastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050413", "l": "D-alanine 2-hydroxymethyltransferase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + D-alanine + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48226", "l": "a neolactoside nLc4Cer(d18:1(4E)) + L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696958", "l": "USP44 deubiquitinates CDC20 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28736", "l": "H(+)(in) + spermidine(out) => H(+)(out) + spermidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018804", "l": "RAC3 GEFs activate RAC3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48553", "l": "1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => (9S,13S,15Z)-12-oxophyto-10-15-dienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5605147", "l": "Defective CYP1B1 does not 4-hydroxylate EST17b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40261", "l": "(3S)-hydroxyhexadecanedioyl-CoA => (2E)-hexadecenedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9675026", "l": "Formation of the MLL1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2512800", "l": "SCARB1:ligand is endocytosed (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196125", "l": "Translocation of isocaproaldehyde from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16729", "l": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70593", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14914", "l": "AMP + thymidine => adenosine + dTMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71937", "l": "glycocholate(in) + 2 Na(+)(in) => glycocholate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71358", "l": "5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out) <=> 5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2396029", "l": "Latent TGF-beta-3 binds integrins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27681", "l": "ATP + dCDP <=> ADP + dCTP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047572", "l": "3-phosphoglycerate phosphatase activity", "d": ["Catalysis of the reaction: 3-phospho-D-glycerate + H2O = D-glycerate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0052597", "l": "diamine oxidase activity", "d": ["Catalysis of the reaction: a diamine + H2O + O2 = a monoamine + NH3 + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938913", "l": "RUNX1 binds ELF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050469", "l": "sabinene-hydrate synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + H2O = diphosphate + sabinene hydrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21647", "l": "ATP + glycerol <=> ADP + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811454", "l": "MAPKs phosphorylate PP2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008469", "l": "histone arginine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64834", "l": "3-hydroxy-benzyl benzoate + CoA => 3-hydroxybenzyl alcohol + benzoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748991", "l": "XDH oxidises 6MP to 6TU (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74986", "l": "Elongation of pre-rRNA transcript (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13334", "l": "beta-D-fructose 2,6-bisphosphate + H2O => beta-D-fructose 2-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49289", "l": "(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] => (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34548", "l": "ATP + cob(II)yrinate + H2O + L-glutamine => ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12694", "l": "3,4-dihydroxypyridine + O-acetyl-L-serine => 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112429", "l": "Formation of FACT complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61438", "l": "AMP + H(+) + phosphate => ADP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14446", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41213", "l": "2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+) => (indol-3-yl)acetate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70186", "l": "2 alpha-isomaltosyl-(1->4)-D-maltotriose <=> alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694433", "l": "MIA2 binds PREB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56950", "l": "H(+) + phosphoenolpyruvate + UDP => pyruvate + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23512", "l": "alpha,alpha-trehalose + phosphate = beta-D-glucose 1-phosphate + D-glucose", "d": []}, {"i": "EC:2.4.1.64", "l": "\"alpha,alpha-trehalose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26024", "l": "8'-apo-beta-carotenol + O2 => (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13062", "l": "O2 + S-sulfanylglutathione => glutathione S,S-dioxide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805638", "l": "KAT6A acetylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28191", "l": "2'-deoxyadenosine + H(+) + H2O => 2'-deoxyinosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28739", "l": "Cd(2+)(in) + H(+)(out) = Cd(2+)(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008330", "l": "protein tyrosine/threonine phosphatase activity", "d": ["Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336417", "l": "DT A:B binds HBEGF and CD9 on the target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24663", "l": "H(+) + L-arginine + NADPH + O2 <=> H2O + N(omega)-hydroxy-L-arginine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62792", "l": "3 H(+) + NADPH + O2 + 2 rubrofusarin B = 2 H2O + NADP(+) + nigerone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57989", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose => (20S)-ginsenoside F2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66473", "l": "(2Z,6E,10E,14E)-geranylfarnesol => 18-episcalar-17(25)-en-19-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69047", "l": "2-nitrobutanedioate <=> fumarate + H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2089971", "l": "Secretion of collagens (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62203", "l": "ethanol + 2 Fe(III)-[cytochrome c] <=> acetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664346", "l": "IL10 gene produces IL10 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68454", "l": "4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone => all-trans-10'-apo-beta-carotenal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810937", "l": "Lamellar bodies bind the early cornified envelope (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2002401", "l": "Association of procollagen type XVIII (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69493", "l": "O2 + octan-1-ol => H2O2 + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22827", "l": "2'-deoxyuridine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191763", "l": "snRNP:Snurportin complex formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003912", "l": "DNA nucleotidylexotransferase activity", "d": ["Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42728", "l": "S-adenosyl-L-methionine + uridine(2791) in 21S rRNA = 2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.168", "l": "\"21S rRNA (uridine(2791)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37728", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17920", "l": "[Glu(-Cys)](n)-Gly + glutathione + H(+) <=> [Glu(-Cys)](n+1)-Gly + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60229", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811427", "l": "COPI vesicle uncoating at the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661474", "l": "Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25433", "l": "beta-D-ribopyranose => beta-D-ribofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18092", "l": "H2O + L-arginyl-[protein] <=> L-citrullyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804596", "l": "APAF1:CYCS binds APIP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12205", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168310", "l": "Release of the RNP into the host cell nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30504", "l": "H2O + N-acetyl-L-glutamate 5-semialdehyde => acetate + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008963", "l": "phospho-N-acetylmuramoyl-pentapeptide-transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71944", "l": "(S)-malate(out) + 3 Na(+)(out) => (S)-malate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43087", "l": "cytidine(34) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198211", "l": "Active TRKA binds IRS1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205319", "l": "Interaction of APS and p-KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39051", "l": "ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60868", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O = a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3858475", "l": "ppDVL recruits RAC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10672", "l": "cyclobutadithymidine in DNA = a thymidine dimer in DNA", "d": []}, {"i": "EC:4.1.99.3", "l": "\"deoxyribodipyrimidine photo-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49193", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033520", "l": "TYSND1 cleaves TYSND1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70404", "l": "(9Z)-hexadecenoyl-CoA + 3-oxosphinganine => CoA + H(+) + N-(9Z-hexadecenoyl)-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48101", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15223", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+) => a CDP-1,2-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449117", "l": "TXLNA (IL14) binds syntaxin1A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12977", "l": "H2O + N-phosphocreatine = creatine + phosphate", "d": []}, {"i": "EC:3.9.1.1", "l": "\"phosphoamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437118", "l": "GPVI stimulates PI3K beta, gamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29441", "l": "Fe(2+)(out) + H(+)(in) => Fe(2+)(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866269", "l": "ARRB bind GPCRs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982637", "l": "Opsins binds G alpha-t (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38066", "l": "2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA <=> 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74894", "l": "CO2(out) <=> CO2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652165", "l": "MAP2K mutants constitutively phosphorylate MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13556", "l": "alpha-D-galactose + ATP <=> ADP + alpha-D-galactose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685230", "l": "CHEK1 phosphorylates RAD51 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62217", "l": "isoepoxydon + NADP(+) => H(+) + NADPH + phyllostine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23618", "l": "alpha-santonin + H(+) + NADPH => 1,2-dihydro-alpha-santonin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53303", "l": "D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O <=> H(+) + N-carbamoyl-D-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60885", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O => (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50156", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804879", "l": "MDM2 ubiquitinates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788611", "l": "HYKK phosphorylates 5HLYS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68209", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol => 1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035169", "l": "Expression of CETP regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862380", "l": "HSD17B13 binds lipid droplets (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63845", "l": "[thioredoxin]-dithiol + cumene hydroperoxide => 2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.2", "l": "\"NAD(P)H dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191654", "l": "c-src associates with Cx43 in gap junctions (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.222", "l": "\"aurachin C monooxygenase/isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39792", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:1990825", "l": "sequence-specific mRNA binding", "d": ["Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40211", "l": "(3S)-hydroxytetradecanedioyl-CoA + NAD(+) = 3-oxotetradecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34373", "l": "(indol-3-yl)acetate + NH4(+) => H2O + indole-3-acetamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33670", "l": "H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2 <=> H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-873917", "l": "Translocation of STAT1 dimer to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389532", "l": "PP2A binds CTLA4 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38623", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77609", "l": "Binding of APOBEC-1 to form editosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018535", "l": "nicotine dehydrogenase activity", "d": ["Catalysis of the reaction: nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35224", "l": "2-oxo-dADP + H2O => 2-oxo-dAMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30007", "l": "ATP + H2O + L-arabinose(out) = ADP + H(+) + L-arabinose(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15678", "l": "5-aminopentanamide + H2O => 5-aminopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362549", "l": "Hh-Np traffics to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72427", "l": "chloride(in) + K(+)(in) = chloride(out) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5228992", "l": "ROCK1,ROCK2 are activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49222", "l": "CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981648", "l": "C4b binding protein binds C4bC2a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48586", "l": "2 lipoxin A4 => 2 H2O + 2 leukotriene A4 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418868", "l": "Recruitment of Src and Fyn to DCC:FADK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169901", "l": "Rap1-GTP complex binds BRAF complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56988", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43038", "l": "2-aminoprop-2-enoate + H(+) + hydrogen sulfide => L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174070", "l": "Association of Cdh1 with the APC/C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75836", "l": "(5S)-hydroperoxy-(6E,8Z)-octadecadienoate + 2 glutathione => (5S)-hydroxy-(6E,8Z)-octadecadienoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68700", "l": "16alpha,17beta-estriol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 16alpha,17beta-estriol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61735", "l": "steviol + UDP-alpha-D-glucose <=> H(+) + steviolmonoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112392", "l": "Resumption of elongation after recovery from pausing (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68937", "l": "ATP + H(+) + NADPH + nonanoate => AMP + diphosphate + NADP(+) + nonanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62660", "l": "2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol = (2'R)-atrovenetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193702", "l": "Part of the ICD migrates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59726", "l": "D-maltoheptaonate + H(+) => D-maltoheptaono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11656", "l": "ATP + holo-[peptidyl-carrier protein] + L-proline = AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.53", "l": "\"L-proline--[L-prolyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015312", "l": "polyamine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20395", "l": "(R)-4'-phosphopantetheine + acetyl-[citrate lyase ACP] => holo-[citrate lyase ACP] + S-acetylphosphopantotheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2203479", "l": "STAB2 (FEEL-2) binds ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74005", "l": "AH2 + yaequinolone E => A + peniprequinolone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018794", "l": "2-hydroxyisobutyrate decarboxylase activity", "d": ["Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9650165", "l": "ASIC trimers bind H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60975", "l": "hexan-1-ol + NAD(+) <=> H(+) + hexanal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953339", "l": "DNPH1 hydrolyses dGMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49884", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33066", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin] <=> NADH + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57106", "l": "4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2) => [(1->4)-alpha-D-galacturonosyl](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008818", "l": "cobalamin 5'-phosphate synthase activity", "d": ["Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3325546", "l": "Defective CD320 does not transport extracellular TCII:Cbl to endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805785", "l": "AKT phosphorylates PHF20 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68975", "l": "A + sn-glycerol 3-phosphate <=> AH2 + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186785", "l": "PDGF-AA clevage by Furin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070524", "l": "11-beta-hydroxysteroid dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.12", "l": "\"peptidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28029", "l": "[thioredoxin]-disulfide + dUDP + H2O <=> [thioredoxin]-dithiol + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40171", "l": "dodecanoyl-CoA + O2 = (2E)-dodecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45418", "l": "15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+) => 11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0062105", "l": "RNA 2'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + RNA = S-adenosyl-L-homocysteine + RNA containing 2'-O-methylribonucleotide."]}, {"i": "RHEA:58956", "l": "a ribonucleotide in RNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59560", "l": "H2O + N,N',N''-triacetylchitotriono-1,5-lactone = H(+) + N,N',N''-triacetylchitotrionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47214", "l": "2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350769", "l": "trans-Golgi Network Coat Activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180739", "l": "Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004715", "l": "non-membrane spanning protein tyrosine kinase activity", "d": ["Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046180", "l": "KSPG is secreted from the cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693478", "l": "HTR1A binds HTR1A agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879222", "l": "MDP:NLRP1 binds ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44811", "l": "1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-10 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031728", "l": "CCR3 chemokine receptor binding", "d": ["Binding to a CCR3 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26335", "l": "2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin => 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33818", "l": "CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate <=> 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.35", "l": "\"phenol beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36409", "l": "diphosphate + H2O + L-threonylcarbamoyladenylate => ATP + hydrogencarbonate + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21342", "l": "2 vanillin => 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419644", "l": "Transphosphorylation of pLIMK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27755", "l": "H2O + methylglyoxal => (R)-lactate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40284", "l": "(R)-carnitine + hexadecanedioyl-CoA => CoA + O-hexadecanedioyl-L-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004042", "l": "acetyl-CoA:L-glutamate N-acetyltransferase activity", "d": ["Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53567", "l": "9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38934", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71796", "l": "(R)-3-hydroxybutanoate(out) + H(+)(out) => (R)-3-hydroxybutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40813", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607758", "l": "CLEC7A binds 1,3-beta-D-glucan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17270", "l": "macrocin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + tylosin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70353", "l": "beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose => beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015360", "l": "acetate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112690", "l": "PTPN11 binds CBL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937792", "l": "RUNX3 binds SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951644", "l": "Release of mature NEDD8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49261", "l": "D-galactose(out) + N(pros)-phospho-L-histidyl-[protein] => D-galactose 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20528", "l": "ATP + ethylamine + L-glutamate <=> ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191299", "l": "Squalene is oxidized to its epoxide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015444", "l": "P-type magnesium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) -> ADP + phosphate + Mg2+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200396", "l": "Creatine transport across the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110011", "l": "Binding of Grb10 to the insulin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110244", "l": "Excision of FapyG by OGG1 glycosylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0001054", "l": "RNA polymerase I activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16626", "l": "acetyl-CoA + hydrogen sulfide => CoA + thioacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73436", "l": "apigenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + ladanein + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852716", "l": "Thrombin, ELANE cleave C5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781953", "l": "YOD1 binds VCP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26515", "l": "cyclohexan-1,2-dione + H2O => 6-oxohexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73418", "l": "(-)-cyclopenine <=> H(+) + methyl isocyanate + viridicatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19321", "l": "N,N-dimethylaniline N-oxide = formaldehyde + N-methylaniline", "d": []}, {"i": "EC:4.1.2.24", "l": "\"dimethylaniline-N-oxide aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44962", "l": "decanoyl-CoA + NADP(+) => (2E)-decenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034713", "l": "type I transforming growth factor beta receptor binding", "d": ["Binding to a type I transforming growth factor beta receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58435", "l": "(E)-4-oxonon-2-en-1-ol + NADP(+) <=> (E)-4-oxonon-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212222", "l": "PRC2 recruits DNA methyltransferases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13142", "l": "2-methylpropanoyl-CoA => butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48538", "l": "1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+) => 1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-379387", "l": "COMT transfers Met to DA to form 3MT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018788", "l": "atrazine chlorohydrolase activity", "d": ["Catalysis of the reaction: atrazine + H2O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855111", "l": "VLDLR binds PCSK9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665989", "l": "DIAPH1 binds RHOA:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173709", "l": "C7 binds C5b:C6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58649", "l": "rifamycin SV hemiaminal => H(+) + rifamycin SV ortho-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050621", "l": "tryptophan alpha,beta-oxidase activity", "d": ["Catalysis of the reaction: L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2 + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59794", "l": "(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate => H2O + NADP(+) + yersinopine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694527", "l": "Loss of SAR1B GTPase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69116", "l": "Formation of Okazaki fragments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75856", "l": "Abortive Initiation Before Second Transition (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20952", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose = beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.188", "l": "\"N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400342", "l": "Expression of ARNTL (BMAL1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39111", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) = 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57372", "l": "H2O + NADPH = (6S)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67482", "l": "CO2 + H2O + kainate + succinate => 2-oxoglutarate + O2 + prekainate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.481603666032214", "identifiers": [{"i": "GO:0016409", "l": "palmitoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38967", "l": "an N-acylsphing-4-enine(in) + ATP + H2O = ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710959", "l": "p-STAT1 dimer binds KPNA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702578", "l": "semaxanib-resistant FLT3 mutants don't bind semaxanib<br> (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67927", "l": "3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate <=> 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36224", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46004", "l": "2-methylpropanal + CoA + NAD(+) = 2-methylpropanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755526", "l": "PIAS4 SUMOylates NR4A2 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18246", "l": "3'-dephospho-CoA + ATP => ADP + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14074", "l": "3-hydroxy-L-glutamate + H(+) => 4-amino-3-hydroxybutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73519", "l": "dUTP(out) + UTP(in) = dUTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41089", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27741", "l": "2'-deoxyguanosine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66430", "l": "D-arabinose(in) + H(+)(in) => D-arabinose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25110", "l": "ADP + H(+) + pyridoxine 5'-phosphate => ATP + pyridoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429683", "l": "CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13530", "l": "(3S)-citramalate => H2O + mesaconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67115", "l": "L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28624", "l": "(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18001", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": []}, {"i": "EC:3.1.1.52", "l": "\"phosphatidylinositol deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975180", "l": "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033976", "l": "2-haloacid dehalogenase (configuration-inverting) activity", "d": ["Catalysis of the reactions: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928645", "l": "EPHB:NMDAR binds TIAM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48979", "l": "5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 <=> CO2 + H2O + NAD(+) + pyocyanin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28834", "l": "D-gluconate(in) + H(+)(in) <=> D-gluconate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29589", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH => 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73358", "l": "beta-alanyl-[peptidyl-carrier protein] + histamine <=> carcinine + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30571", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine = 6 AMP + 6 diphosphate + enterobactin + 4 H(+)", "d": []}, {"i": "EC:6.3.2.14", "l": "\"enterobactin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684261", "l": "MAP3K8 is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375138", "l": "CDO binds BOC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850797", "l": "SPINK6 binds KLK13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8957241", "l": "TP73 tetramer translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31396", "l": "15-cis-4,4'-diapophytoene + FAD + H(+) => all-trans-4,4'-diapophytofluene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43478", "l": "10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate => (6Z,9Z,12Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23245", "l": "propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + norspermidine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66847", "l": "asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase] <=> asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41573", "l": "lipoxin A4 + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62779", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.188", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43002", "l": "(1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610723", "l": "GLI proteins bind SUFU (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21831", "l": "H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852552", "l": "MST1R autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46147", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43885", "l": "3-oxochol-4-en-22-oyl-CoA + NAD(+) => 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706319", "l": "Active FLT3 binds to SLA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66448", "l": "(E)-pent-2-en-1-ol + NADP(+) = (E)-2-pentenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12754", "l": "glycerol + NADP(+) => dihydroxyacetone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "47.427569271370956", "identifiers": [{"i": "GO:0016491", "l": "oxidoreductase activity", "d": ["Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26186", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40482", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13626", "l": "A + H2O + N(6)-dimethylallyladenine => 3-methyl-2-butenal + adenine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12326", "l": "L-asparagine + N-acetyl-D-glucosamine => H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004790", "l": "thioether S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.329", "l": "\"2-deoxy-scyllo-inosamine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34826", "l": "(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O <=> CO2 + 2 CoA + curcumin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198983", "l": "NKG2D homodimer interacting with ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042973", "l": "glucan endo-1,3-beta-D-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36958", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA <=> (9Z)-pentadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59508", "l": "fumarate + L-cysteinyl-[protein] = S-(2-succinyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25834", "l": "H(+) + NADH + scyllo-inosine => 1D-chiro-inositol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106283", "l": "ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: NAD+ + ursodeoxycholate = 7-oxolithocholate + H+ + NADH."]}, {"i": "RHEA:42028", "l": "NAD(+) + ursodeoxycholate = 7-oxolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784648", "l": "CREB3L3 (1-?) translocates from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49234", "l": "D-mannose 6-phosphate(in) + L-histidyl-[protein] => D-mannose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638845", "l": "CERK phosphorylates CERA to form C1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68246", "l": "L-phenylalanine(out) + Na(+)(out) => L-phenylalanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15848", "l": "4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose <=> 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34162", "l": "acetyl-CoA + UDP-N-acetylbacillosamine <=> CoA + H(+) + UDP-N,N'-diacetylbacillosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35505", "l": "30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183067", "l": "Localization of CBL:GRB2 to the membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810076", "l": "DDO oxidizes D-Asp to OA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54829", "l": "dimethylamine + H(+) + NADPH + O2 => formaldehyde + H2O + methylamine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59011", "l": "H2O + O2 + salicylaldehyde <=> H(+) + H2O2 + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388596", "l": "Melanocortin receptors bind melanocortins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24366", "l": "2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34037", "l": "6'-oxoparomamine + H2O2 => O2 + paromamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211960", "l": "CYP2U1 19-hydroxylates ARA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102395", "l": "9-cis-beta-carotene 9',10'-cleavage oxygenase activity", "d": ["Catalysis of the reaction: 9-cis-beta-carotene + O2 <=> 9-cis-10'-apo-beta-carotenal + beta-ionone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63415", "l": "2,4,6-trichlorophenol + FADH2 + O2 <=> 2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16916", "l": "a CDP-1,2-diacyl-sn-glycerol + L-serine <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047919", "l": "GDP-mannose 6-dehydrogenase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose + H2O + 2 NAD+ = GDP-D-mannuronate + 3 H+ + 2 NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874083", "l": "p-Y397-PTK2 binds SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165195", "l": "GTP loading by Rheb (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874979", "l": "ACBD3 binds GOLGB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52832", "l": "1-hydroxylimonen-2-one + H(+) + NADPH + O2 = 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174367", "l": "GCL ligates L-Glu to L-Cys (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877187", "l": "P2X7 mediates loss of intracellular K+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16777", "l": "ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate", "d": []}, {"i": "EC:7.2.2.6", "l": "\"P-type K(+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16993", "l": "6 Fe(III)-[cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] = 6 Fe(II)-[cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": []}, {"i": "EC:1.8.2.6", "l": "\"S-disulfanyl-L-cysteine oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59968", "l": "L-threonyl-[protein] + octanoyl-CoA = CoA + O-octanoyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570528", "l": "SUMOylation of XPC with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46873", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA => a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35331", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6795290", "l": "TORC2 complex phosphorylates SGK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29957", "l": "H(+)(out) + thymidine(out) => H(+)(in) + thymidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55582", "l": "AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate => ATP + H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66549", "l": "3'-phosphoadenylyl sulfate + 4-nitrophenol => 4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31892", "l": "2-hydroxy-1-phenyl-1-propanone + NADP(+) => 1-phenyl-1,2-propanedione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0016785", "l": "selenotransferase activity", "d": ["Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.9.1.-", "l": "\"Selenotransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19488", "l": "sphing-4-enine + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21990", "l": "4'''-demalonylsalvianin + CoA => malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56389", "l": "(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 => (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39364", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA => (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936963", "l": "IRAK2 induces TRAF6 oligomerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34170", "l": "2,6-dihydroxypseudooxynicotine + H2O <=> 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19343", "l": "H2O + octan-1-ol + 2 oxidized [rubredoxin] => 2 H(+) + O2 + octane + 2 reduced [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56851", "l": "1,6-didemethyltoxoflavin + S-adenosyl-L-methionine <=> H(+) + reumycin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449117", "l": "TXLNA (IL14) binds syntaxin1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209792", "l": "N-acetylation of serotonin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68300", "l": "L-seryl-[protein] + tetradecanoyl-CoA = CoA + O-tetradecanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67433", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0016273", "l": "arginine N-methyltransferase activity", "d": ["Enables the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54705", "l": "N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23663", "l": "4-imidazolone-5-propanoate + H2O <=> N-formimidoyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28903", "l": "D-alanine(in) + H(+)(in) = D-alanine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72145", "l": "3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine => AH2 + GTP + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989767", "l": "Expression of TRIB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211224", "l": "Association of DFF40 with DFF45 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33401", "l": "L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in) => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49347", "l": "2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607043", "l": "factor VIIIa associates with cell membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10218", "l": "ADP + H(+) + phospho-[DNA-directed RNA polymerase] => [DNA-directed RNA polymerase] + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990162", "l": "histone H3K4 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 4) + H2O = histone H3 L-lysine (position 4) + acetate. This reaction represents the removal of an acetyl group from lysine at position 4 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21649", "l": "H(+) + prephenate => 3-phenylpyruvate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381087", "l": "Dimerization of PERK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800120", "l": "POU5F1 (OCT4), SOX2, NANOG bind DPPA4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33416", "l": "bornane-2,6-dione + H2O => [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31014", "l": "(S)-2,3-epoxysqualene <=> camelliol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42340", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) = 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52060", "l": "12-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57930", "l": "ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate => ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296244", "l": "SUCNR1 binds SUCCA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981931", "l": "RAC1 and CDC42 activate PAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688834", "l": "ATXN3 binds VCP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-451033", "l": "(S)-Malate <=> Fumarate + H2O (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004185", "l": "serine-type carboxypeptidase activity", "d": ["Catalysis of the hydrolysis of a single C-terminal amino acid residue from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17703", "l": "3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate => ATP + geranoyl-CoA + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047516", "l": "1,3-propanediol dehydrogenase activity", "d": ["Catalysis of the reaction: propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042009", "l": "interleukin-15 binding", "d": ["Binding to interleukin-15."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621571", "l": "CD209 binds ICAM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46736", "l": "H2O + monoacyl-sn-glycero-3-phosphate = a monoacylglycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45489", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33827", "l": "ergosterol = vitamin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63210", "l": "5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O => 5-amino-6-(D-ribitylamino)uracil + glyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42563", "l": "uridine(27/28) in mitochondrial tRNA <=> pseudouridine(27/28) in mitochondrial tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53032", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70097", "l": "peniphenone D => (R)-5-methyl-tetronate + o-quinone methide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694442", "l": "CNIH2,3 bind GRIA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39363", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA = (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42581", "l": "ATP + L-serine + tRNA(Sec) => AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64241", "l": "glycine + octanoyl-CoA => CoA + H(+) + N-octanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429860", "l": "DCP1-DCP2 complex decaps mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39310", "l": "(2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH <=> (11Z,14Z)-eicosadienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14983", "l": "androst-4-ene-3,17-dione + H(+) + NADPH => NADP(+) + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182795", "l": "RNase H-mediated degradation of the template strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66744", "l": "ATP + H2O + N-acetyl-L-aspartate(in) = ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34435", "l": "4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine = 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.261", "l": "\"4-dimethylallyltryptophan N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73065", "l": "H(+)(in) + Mn(2+)(out) => H(+)(out) + Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2247513", "l": "STAB1:ligand is endocytosed (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034570", "l": "hydroxymonomethylisoproturon dimethylaminedehydrogenase activity", "d": ["Catalysis of the reaction: hydroxymonodemethylisoproturon + H2O = formaldehyde + 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149434", "l": "Transport of GAG to the Plasma Membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60884", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O = (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40058", "l": "1,2,3-trioctanoylglycerol + H2O <=> 2,3-dioctanoyl-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047315", "l": "kynurenine-glyoxylate transaminase activity", "d": ["Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690740", "l": "CD22 binds B-cell receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69225", "l": "a (Z)-alkenyl glucosinolate + H2O => a (Z)-N-(sulfonatooxy)alkenimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59100", "l": "diglucosyl-enterobactin + UDP-alpha-D-glucose = H(+) + triglucosyl-enterobactin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65075", "l": "(2E,6E)-farnesyl diphosphate <=> dauca-4,7-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247843", "l": "secretion of WNT ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392870", "l": "Gs activation by prostacyclin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697043", "l": "Protease binds protease inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57321", "l": "acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] => CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37972", "l": "H(+) + NADPH + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54367", "l": "2 acetaldehyde <=> acetoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58110", "l": "acetate + L-lysyl-[protein] => H2O + N(6)-acetyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72663", "l": "De novo formation of eIF2:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334160", "l": "UHRF1:Chromatin binds DNMT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250280", "l": "ROS oxidize thioredoxin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62684", "l": "norrubrofusarin + S-adenosyl-L-methionine = H(+) + rubrofusarin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35304", "l": "3-hydroxyisopentadecanoyl-CoA + NADP(+) => 3-oxoisopentadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44566", "l": "4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-decaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68473", "l": "(2Z,6Z)-farnesyl diphosphate => (E)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56350", "l": "2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+) => 4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102879", "l": "(+)-thujopsene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-thujopsene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034855", "l": "4-AD 9alpha-hydroxylase activity", "d": ["Catalysis of the reaction: androst-4-ene-3,17-dione + O2 + 2 H+ + 2 e- = 9alpha-hydroxy-4-androstene-3,17-dione + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873926", "l": "IFNG dimer binds IFNGR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.07563785880906", "identifiers": [{"i": "GO:0008514", "l": "organic anion transmembrane transporter activity", "d": ["Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688377", "l": "Defective pro-SFTPC does not translocate from ER membrane to multivesicle body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23575", "l": "3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + phlorisovalerophenone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047132", "l": "dihydrobenzophenanthridine oxidase activity", "d": ["Catalysis of the reaction: O2 + dihydrosanguinarine = H2O2 + sanguinarine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004747", "l": "ribokinase activity", "d": ["Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16924", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018743", "l": "phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity", "d": ["Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19069", "l": "(R)-S-lactoylglutathione = glutathione + methylglyoxal", "d": []}, {"i": "EC:4.4.1.5", "l": "\"lactoylglutathione lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858428", "l": "FCAMR binds IgA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0034072", "l": "squalene cyclase activity", "d": ["Catalysis of the reaction: squalene = triterpene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712195", "l": "ANO2 dimer binds Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870465", "l": "RGGT binds the RAB-binding subunit (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77068", "l": "Activation of GT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28603", "l": "L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32468", "l": "2 S-adenosyl-L-methionine + sarcosine => glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16421", "l": "an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.2.7.5", "l": "\"aldehyde ferredoxin oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45128", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4615910", "l": "SUMOylation of PCNA with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75266", "l": "isovitexin + O2 <=> 3'-dehydroisovitexin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863587", "l": "CDK5:p25 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32611", "l": "(6E)-8-hydroxygeranial + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449115", "l": "IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32490", "l": "CDP-choline + H2O <=> CMP + 2 H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624798", "l": "LBR binds KPNB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35070", "l": "(S)-carnitine(out) <=> (S)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13946", "l": "(S)-mandelate => (R)-mandelate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13328", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine <=> 3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2203516", "l": "Alpha-1-Microglobulin is cleaved (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42983", "l": "L-tyrosine <=> 2-aminoprop-2-enoate + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34044", "l": "5-phospho-alpha-D-ribose 1-diphosphate + neamine => 5''-phosphoribostamycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10652", "l": "a long-chain fatty aldehyde + H2O + NAD(+) = a long-chain fatty acid + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.48", "l": "\"long-chain-aldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.121", "l": "\"polymannuronate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14930", "l": "NAD(+) + testosterone => androst-4-ene-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.45", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57274", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA => a 2'-deoxyguanosine in DNA + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57384", "l": "(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA = (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA", "d": []}, {"i": "EC:2.3.1.285", "l": "\"(13S,14R)-1,13-dihydroxy-N-methylcanadine 13-O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33157", "l": "a 1-acyl-sn-glycerol + phosphate => a 1-acyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164834", "l": "Enzyme-bound ATP is released (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76004", "l": "glutarate(in) + xanthurenate(out) => glutarate(out) + xanthurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59051", "l": "D-ornithine + H(+) <=> CO2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51304", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate = (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10876", "l": "4-hydroxybenzoate + H(+) = CO2 + phenol", "d": []}, {"i": "EC:4.1.1.61", "l": "\"4-hydroxybenzoate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28529", "l": "(R)-carnitine + crotonobetainyl-CoA <=> (R)-carnitinyl-CoA + crotonobetaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50152", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015390", "l": "purine-specific nucleoside:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47972", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O", "d": []}, {"i": "EC:4.2.1.159", "l": "\"dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865482", "l": "KMT2A (MLL) binds RUNX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205238", "l": "SHP2 interacts with p-KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55253", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine => 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54262", "l": "(3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-asparaginyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.9", "l": "\"agaritine gamma-glutamyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433501", "l": "Interaction of other adapter proteins with p-KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22387", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O <=> 1D-myo-inositol hexakisphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53010", "l": "di-trans,poly-cis-polyprenyl diphosphate + n diphosphate => (2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72032", "l": "(E)-sinapyl alcohol + O2 => (E)-sinapaldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.109", "l": "\"dolichyl-phosphate-mannose--protein mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36698", "l": "dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid <=> desmethyldescarbamoylnovobiocin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047842", "l": "dehydro-L-gulonate decarboxylase activity", "d": ["Catalysis of the reaction: 3-dehydro-L-gulonate + H+ = L-xylulose + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2219524", "l": "PDPK1 binds PIP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23174", "l": "ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] => ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8934465", "l": "SHC1 binds PTPN12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408555", "l": "Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63189", "l": "3,4-dihydroxybenzaldehyde + AH2 + tyramine => A + H2O + norbelladine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40255", "l": "(2E)-hexadecenedioyl-CoA + H2O = (3R)-hydroxyhexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685195", "l": "SARS-CoV-1 9b recruits ITCH to MAVS  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28377", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15874", "l": "[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose => [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427336", "l": "TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23325", "l": "2'-phospho-[ligated tRNA] + NAD(+) => ADP-alpha-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102928", "l": "beta-solanine rhamnosyltransferase activity", "d": ["Catalysis of the reaction: beta-solanine + UDP-L-rhamnose = solanine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43620", "l": "L-serine + NADP(+) = aminoacetaldehyde + CO2 + NADPH", "d": []}, {"i": "EC:1.1.1.276", "l": "\"serine 3-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60347", "l": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41501", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46319", "l": "GDP-N,N'-diacetylbacillosamine + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18090", "l": "H2O + L-arginyl-[protein] => L-citrullyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73797", "l": "FAICAR => IMP + H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177923", "l": "Sustained activation of SRC kinase by SHP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36612", "l": "(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 => (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46973", "l": "A + dihydrobisanhydrobacterioruberin => AH2 + bisanhydrobacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44955", "l": "(2E)-octenoyl-CoA + H(+) + NADPH <=> NADP(+) + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33008", "l": "(+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37353", "l": "cytidine + phosphate => cytidine 2'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047270", "l": "lipopolysaccharide glucosyltransferase II activity", "d": ["Catalysis of the reaction: lipopolysaccharide + UDP-D-glucose = D-glucosyl-lipopolysaccharide + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9761421", "l": "CDH11 associates with catenins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47767", "l": "S-adenosyl-L-methionine + uridine(1369) in 16S rRNA <=> 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047353", "l": "N-methylphosphoethanolamine cytidylyltransferase activity", "d": ["Catalysis of the reaction: N-methylethanolamine phosphate + CTP = CDP-N-methylethanolamine + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3204311", "l": "AOX1 oxidises PXL to PDXate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64104", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein] = 1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56695", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64765", "l": "S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine => 2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167111", "l": "Extrusion of 5'-end of 30 nt long HIV-1 transcript through the pore in Pol II complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29421", "l": "H(+)(in) + Na(+)(out) => H(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877192", "l": "RUNX1 binds FOXP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247999", "l": "EGFRvIII mutant binds chaperone proteins HSP90 and CDC37. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.9", "l": "\"nitroquinoline-N-oxide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17645", "l": "H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] = N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21130", "l": "fecosterol + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008447", "l": "L-ascorbate oxidase activity", "d": ["Catalysis of the reaction: 4 L-ascorbate + O2 <=> 4 monodehydroascorbate + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74179", "l": "a secondary alkyl amine + H2O + NADP(+) = a ketone + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16296", "l": "2-isopropylmaleate + H2O <=> (2S)-2-isopropylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30390", "l": "GDP-alpha-D-glucose + phosphate <=> alpha-D-glucose 1-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83650", "l": "FasL:Fas binds FADD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928645", "l": "EPHB:NMDAR binds TIAM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029456", "l": "RAC1 and CDC42 activate PAK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12447", "l": "hexadecanal + NADP(+) <=> (2E)-hexadecenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018832", "l": "halohydrin hydrogen-halide-lyase B activity", "d": ["Catalysis of the elimination of HCl from a chloropropanol, yielding an epoxypropane."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034928", "l": "1-hydroxypyrene 6,7-monooxygenase activity", "d": ["Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-6,7-oxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33799", "l": "L-histidinol + NAD(+) = H(+) + L-histidinal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50887", "l": "(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O <=> (9Z-octadecenoyl)-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.63", "l": "\"beta-amyrin 16beta-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14444", "l": "acetyl-CoA + gentamicin C <=> CoA + H(+) + N(3)-acetylgentamycin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14876", "l": "indole-3-ethanol + NAD(+) <=> H(+) + indole-3-acetaldehyde + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56462", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine => H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033854", "l": "glutamate-prephenate aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-arogenate = L-glutamate + prephenate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57187", "l": "L-cysteinyl-[protein] + methylglyoxal <=> S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68353", "l": "pppA(2'-5')pG => 3',2'-cGAMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70681", "l": "glycine betaine(out) + H(+)(out) => glycine betaine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57499", "l": "2-methylcitrate <=> 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9676160", "l": "AAMP binds NOD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168400", "l": "iE-DAP elicits a NOD1 response (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15748", "l": "[(2->1)-beta-D-fructosyl](n) + sucrose <=> [(2->1)-beta-D-fructosyl](n+1) + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59340", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A = 1'-hydroxy-demethylspheroidene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634834", "l": "ACHEIs bind ACHE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13745", "l": "ascopyrone M = microthecin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45382", "l": "(4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27433", "l": "2 glutathione amide + NAD(+) = glutathione amide disulfide + H(+) + NADH", "d": []}, {"i": "EC:1.8.1.16", "l": "\"glutathione amide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818010", "l": "CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer binds SRC family kinases FYN,HCK,SRC,YES1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62909", "l": "nor-toralactone + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + toralactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38412", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O => (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60123", "l": "(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine <=> H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047160", "l": "alkylglycerophosphate 2-O-acetyltransferase activity", "d": ["Catalysis of the reaction: 1-alkyl-sn-glycerol 3-phosphate + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665034", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59837", "l": "H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] => 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57534", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate => a 5'-end ribonucleotide-RNA + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018758", "l": "RHOH binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39955", "l": "(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.54", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59737", "l": "L-cysteinyl-[protein] + tetradecanoyl-CoA => CoA + S-tetradecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54608", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20856", "l": "an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine", "d": []}, {"i": "EC:3.5.1.23", "l": "\"ceramidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17890", "l": "H2O + phosphoethanolamine => acetaldehyde + NH4(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31693", "l": "(9R)-hydroperoxy-(10E,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70609", "l": "4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 4-ethylphenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43859", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53772", "l": "chenodeoxycholate + lithocholoyl-CoA = chenodeoxycholoyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75994", "l": "a dicarboxylate(in) + N-benzoylglycine(out) <=> a dicarboxylate(out) + N-benzoylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549322", "l": "OCT1 transports organic cations out of hepatic cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33440", "l": "glyoxal + H2O + O2 => glyoxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689085", "l": "ATXN3 binds polyUb-PARK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67590", "l": "a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+) => a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36972", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-allose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29414", "l": "glycolate(in) + H(+)(in) <=> glycolate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20757", "l": "(E)-caffeoyl-CoA + D-threo-isocitrate => 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58176", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH = all-trans-lycopaoctaene + 2 diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866941", "l": "MID1IP1 binds THRSP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68721", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 26-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35177", "l": "novobiocin(out) => novobiocin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58351", "l": "2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46485", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39138", "l": "(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2 <=> (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4332356", "l": "CAMK2 binds MAP3K7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662466", "l": "XYLB phosphorylates D-xylulose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34101", "l": "CO2 + norspermidine => carboxynorspermidine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805035", "l": "TP53 binds STK11 and NUAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047868", "l": "dimethylmaleate hydratase activity", "d": ["Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784204", "l": "JAKs bind OSMR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18353", "l": "ATP + H2O + K(+)(out) + Na(+)(in) = ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate", "d": []}, {"i": "EC:7.2.2.13", "l": "\"Na(+)/K(+)-exchanging ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67574", "l": "adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + alpha-muricholate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.116918913335823", "identifiers": [{"i": "GO:0034062", "l": "5'-3' RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984689", "l": "Kinesin-7 is a dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38915", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051062", "l": "UDP reductase activity", "d": ["Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50476", "l": "anthraniloyl-CoA + L-cysteinyl-[PqsD protein] = CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653514", "l": "USP17L2 deubiquitinates RCE1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430308", "l": "PARVB interacts with Alpha-actinin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57225", "l": "glyoxal + GTP => N(2)-(1-hydroxy-2-oxoethyl)-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23146", "l": "2 H(+) + N-acetyl-D-glucosaminate + NADH => H2O + N-acetyl-alpha-D-glucosamine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102623", "l": "scutellarein 7-methyl ether 6-O-methyltransferase activity", "d": ["Catalysis of the reaction: scutellarein 7-methyl ether + S-adenosyl-L-methionine <=> cirsimaritin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17501", "l": "H2O + polyneuridine aldehyde = 16-epivellosimine + CO2 + methanol", "d": []}, {"i": "EC:3.1.1.78", "l": "\"polyneuridine-aldehyde esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16068", "l": "2-oxoglutarate + O2 + phytanoyl-CoA <=> 2-hydroxyphytanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18933", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.107", "l": "\"3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693243", "l": "RHOD translocates to the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30138", "l": "dodecanoyl-CoA + H2O <=> CoA + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64792", "l": "L-lysine + NADP(+) = 2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48820", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985157", "l": "OAS3 binds viral dsRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445072", "l": "Interaction of PAK1 with Rac1-GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63449", "l": "(2-aminoethyl)phosphonate + CTP => CMP-(2-aminoethyl)phosphonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49866", "l": "(+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+) => (+)-dehydrodiconiferyl acid + 2 a quinone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755258", "l": "DDX58 binds SARS-CoV-2 dsRNA intermediates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55700", "l": "an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O = an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37148", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13245", "l": "D-threo-isocitrate = glyoxylate + succinate", "d": []}, {"i": "EC:4.1.3.1", "l": "\"isocitrate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050077", "l": "maleylpyruvate isomerase activity", "d": ["Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66770", "l": "ADP + coproporphyrin I(out) + H(+) + phosphate => ATP + coproporphyrin I(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170149", "l": "Translocation of active Cdc25C to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46541", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614591", "l": "Excess cysteine yields lanthionine and H2S (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17921", "l": "D-arabinitol + NAD(+) = D-xylulose + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.11", "l": "\"D-arabinitol 4-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73322", "l": "(2R,3S)-piscidate + (E)-4-coumaroyl-CoA <=> cimicifugate K + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47455", "l": "(2E,5Z)-tetradecadienoyl-CoA + H2O <=> (3S)-hydroxy-(5Z-tetradecenoyl)-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009072", "l": "STAT3 phosphorylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16697", "l": "A + H2O + quinaldate = AH2 + kynurenate", "d": []}, {"i": "EC:1.3.99.18", "l": "\"quinaldate 4-oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49761", "l": "EDTA + FMNH2 + O2 => ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090417", "l": "N-methylnicotinate transmembrane transporter activity", "d": ["Enables the transfer of N-methylnicotinate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69133", "l": "cadaverine + H2O + O2 => 5-aminopentanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421485", "l": "Translocation of coproporphyrinogen III from the cytosol to the mitochondrial intermembrane space (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5626549", "l": "IQGAPs bind CALM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11313", "l": "atrazine + H2O => chloride + H(+) + hydroxyatrazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55698", "l": "an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate => a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21954", "l": "H(+) + NADPH + progesterone => 5alpha-pregnane-3,20-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944230", "l": "Association of procollagen type XVIII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70134", "l": "3-dehydro-6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-dehydro-28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41312", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57481", "l": "2-hydroxydodecanoate + H2O2 => 2,3-dihydroxydodecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218806", "l": "FYN autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33124", "l": "all-trans-heptaprenyl diphosphate => (R)-tetraprenyl-beta-curcumene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30522", "l": "GTP + H(+) + phosphoenolpyruvate <=> diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18908", "l": "H2O + phosphonoacetaldehyde <=> acetaldehyde + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654511", "l": "FGFRL1 dimer binds FGFs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215406", "l": "PRMT5 binds WDR77 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036106", "l": "peroxisome membrane class-2 targeting sequence binding", "d": ["Binding to a class II peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-independent manner."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16826", "l": "ATP + uridine => ADP + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647632", "l": "CASP3 cleaves GSDME (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16907", "l": "a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867344", "l": "OMA1 hydrolyses OPA1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686343", "l": "IAV NS1 binds MLKL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.116", "l": "\"D-ornithine/D-lysine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001616", "l": "growth hormone secretagogue receptor activity", "d": ["Combining with ghrelin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75432", "l": "32-hydroxyeburicol + O2 + reduced [NADPH--hemoprotein reductase] => 32-oxoeburicol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017835", "l": "NOTCH1 coactivator complex binds NOTCH3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42880", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermine = H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877902", "l": "Activated AR binds RUNX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50121", "l": "taurine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67972", "l": "ATP + ecdysone = ADP + ecdysone 22-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2106625", "l": "Duplex siRNA is loaded into Argonaute (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.52", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12364", "l": "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = a quinol + beta-nicotinamide D-riboside", "d": []}, {"i": "EC:1.10.5.1", "l": "\"ribosyldihydronicotinamide dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443439", "l": "c-Src binds Raf1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047057", "l": "vitamin-K-epoxide reductase (warfarin-sensitive) activity", "d": ["Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19905", "l": "NAD(+) + spermidine = dehydrospermidine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44733", "l": "2-(9Z,12Z-octadecadienoyl)-glycerol + H2O => (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73800", "l": "SAICAR => AICAR + Fumarate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683840", "l": "SFTPB gene produces pro-SFTPB protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389972", "l": "alpha-tubulin:GTP + Cofactor B -> alpha-tubulin:GTP: Cofactor B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375140", "l": "CDO binds promyogenic cadherins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50439", "l": "prostaglandin H1 <=> prostaglandin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42797", "l": "(9Z,12Z)-octadecadienoyl-CoA + cholesterol => cholesteryl (9Z,12Z)-octadecadienoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871266", "l": "YAP1 binds TEAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210277", "l": "Interaction of PECAM-1 and SHP-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189406", "l": "4 PBGs bind to form HMB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433967", "l": "Dimerized Phospho-IRF3 is Transported To The Nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981621", "l": "Neuroglobin:oxygen dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39460", "l": "(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73577", "l": "CAD hexamer transforms L-Gln to CAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14502", "l": "H2O + L-homocysteine => 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.198", "l": "\"alpha-selinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003844", "l": "1,4-alpha-glucan branching enzyme activity", "d": ["Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13901", "l": "H2O + N-(aminomethyl)urea = N-(hydroxymethyl)urea + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018423", "l": "protein C-terminal leucine carboxyl O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein."]}, {"i": "REACT:R-HSA-8856945", "l": "PP2A methylation by LCMT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43667", "l": "ATP + hydrogencarbonate + tetracosanoyl-CoA <=> 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050023", "l": "L-fuconate dehydratase activity", "d": ["Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086079", "l": "gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from a Purkinje myocyte to a ventricular cardiac muscle cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9656893", "l": "OPN1MW binds 11cRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42572", "l": "3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) = 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63721", "l": "losartan + UDP-alpha-D-glucuronate => losartan-2-N-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35163", "l": "H(+)(out) + minocycline(in) = H(+)(in) + minocycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12196", "l": "keto-D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O", "d": []}, {"i": "EC:4.1.2.22", "l": "\"fructose-6-phosphate phosphoketolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390593", "l": "ATP Hydrolysis By Myosin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34095", "l": "carboxyspermidine + H(+) = CO2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68309", "l": "1D-myo-inositol hexakisphosphate + H2O => 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13143", "l": "butanoyl-CoA => 2-methylpropanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696268", "l": "RND3 binds effectors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12683", "l": "N-methylhydantoin + NH4(+) => creatinine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56510", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201717", "l": "CSNK2-mediated phosphorylation of DVL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975040", "l": "KRAB-ZNF / KAP Interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023348", "l": "MECP2 binds DLL1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102385", "l": "patchoulol synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> seychellene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15986", "l": "formate + NAD(+) => CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30349", "l": "ADP + ITP => ATP + IDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15584", "l": "biochanin A 7-O-beta-D-glucoside + malonyl-CoA <=> biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0000224", "l": "peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity", "d": ["Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38167", "l": "hexadecan-1-ol + hexadecanoyl-CoA = CoA + hexadecanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19483", "l": "3-oxoadipyl-CoA + CoA => acetyl-CoA + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067659", "l": "Assembly of hexameric IL-6 receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653886", "l": "B4GALT1 binds LALBA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015445", "l": "P-type silver transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ag+(in) -> ADP + phosphate + Ag+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19845", "l": "nocardicin E + S-adenosyl-L-methionine = H(+) + isonocardicin A + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008892", "l": "guanine deaminase activity", "d": ["Catalysis of the reaction: guanine + H2O = xanthine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651809", "l": "LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34965", "l": "Na(+)(out) => Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694441", "l": "CSNK1D phosphorylates SEC23 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30832", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55834", "l": "6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cortisone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64439", "l": "glycylglycyl-L-isoleucine(out) + H(+)(out) <=> glycylglycyl-L-isoleucine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30954", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> alpha-eudesmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2152276", "l": "Secretion of transmembrane collagens (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404200", "l": "IGF1,2 binds IGF1R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-354077", "l": "Integrin alphaIIb beta3 activation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653936", "l": "Formation of Ragulator complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59197", "l": "holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP => AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110307", "l": "REV1 binds AP-dsDNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.44", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871266", "l": "YAP1 binds TEAD3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685179", "l": "SARS-CoV-1 N protein binds TRIM25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29988", "l": "adenosine(in) + H(+)(in) => adenosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30622", "l": "2 A + all-trans-zeta-carotene <=> 2 AH2 + all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507870", "l": "Aquaporins passively transport water out of cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236970", "l": "Proteasomal clevage of exogenous antigen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46057", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (11E,13Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39263", "l": "(2E,13Z)-docosadienoyl-CoA + H(+) + NADPH = (13Z)-docosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.51", "l": "\"HycI peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60619", "l": "N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine <=> ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17127", "l": "2-oxoglutarate + N-(2-aminobutanoyl)glycine => H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389381", "l": "Gads binds CD28 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15079", "l": "(R)-pantetheine + CO2 => H(+) + N-[(R)-pantothenoyl]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034789", "l": "2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + phthalate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5626938", "l": "Beta-catenin binds SOX proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72915", "l": "D-fructopyranose(out) + Na(+)(out) = D-fructopyranose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68315", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O <=> 1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903981", "l": "enterobactin binding", "d": ["Binding to enterobactin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52619", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP <=> 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38750", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19891", "l": "diphosphate + UDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + H(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211400", "l": "Anthrax lef cleaves target cell MAP2K3 (MEK3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-877187", "l": "P2X7 mediates loss of intracellular K+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38723", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51428", "l": "acetyl-CoA + aminomethylphosphonate = 2-N-acetamidomethylphosphonate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74707", "l": "Binding of IRS to insulin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34517", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP => tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58401", "l": "heptan-1-ol + NADP(+) => H(+) + heptanal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177923", "l": "Sustained activation of SRC kinase by SHP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725009", "l": "NPM-ALK translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015411", "l": "ABC-type taurine transporter transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5660980", "l": "p-S276-RELA binds RELB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28421", "l": "(R)-carnitine + 4-(trimethylamino)butanoyl-CoA <=> (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17726", "l": "(2S,3S)-2-methylcitrate => 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000994", "l": "RNA polymerase III core binding", "d": ["Binding to an RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848335", "l": "IL37 binds  IL18R1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49300", "l": "D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] = alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.208", "l": "\"protein-N(pi)-phosphohistidine--maltose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673794", "l": "ppDVL:RAC1:GTP binds NOX1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15518", "l": "H2O + N(2),6-disulfo-D-glucosamine => H(+) + N-sulfo-D-glucosamine + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6790038", "l": "Expression of HSP90B1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3858482", "l": "DVL is recruited to the receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39456", "l": "(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20152", "l": "O2 + quinine + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70306", "l": "beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-octanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15177", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": []}, {"i": "EC:3.1.1.5", "l": "\"lysophospholipase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70065", "l": "a (22S)-22-hydroxy C28-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C28-steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64033", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17067", "l": "(R)-5-phosphomevalonate + ADP + H(+) => (R)-mevalonate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57810", "l": "3-chlorocatechol + NAD(+) + nitrite => 1-chloro-3-nitrobenzene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68595", "l": "(6S)-5,6,7,8-tetrahydrofolate(out) + ATP + H2O <=> (6S)-5,6,7,8-tetrahydrofolate(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102872", "l": "1-16:0-2-18:2-phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74788", "l": "L-histidyl-L-proline diketopiperazine(in) => L-histidyl-L-proline diketopiperazine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395764", "l": "atREs binds to nascent CM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928656", "l": "gamma-secretase cleaves EPHB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679205", "l": "ULK1 phosphorylates Beclin-1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683393", "l": "nsp15 binds nsp8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102927", "l": "beta-chaconine rhamnosyltransferase activity", "d": ["Catalysis of the reaction: beta-chaconine + UDP-L-rhamnose = H+ + alpha-chaconine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350453", "l": "RHOGAPP190 binds to RHO1:GTP complex at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70435", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + O2 = a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3132759", "l": "TCN1 binds RCbl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726580", "l": "PGR binds PGR agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14891", "l": "(5Z,7E,9E,14Z,17Z)-icosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021945", "l": "MECP2 binds GAMT gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62113", "l": "(3S)-3-hydroxy-D-aspartate => H2O + iminosuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39136", "l": "(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2 => (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004991", "l": "parathyroid hormone receptor activity", "d": ["Combining with parathyroid hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47605", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) => CMP + ganglioside GP1calpha (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56575", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose <=> globoside Gb3Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10087", "l": "3,4-dihydroxybenzoate + O2 <=> 3-carboxy-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871373", "l": "BMX phosphorylates RUFY1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56722", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] => 2 Fe(III)-[cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099507", "l": "ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "d": ["Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48228", "l": "a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]", "d": []}, {"i": "EC:2.3.1.269", "l": "\"apolipoprotein N-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909552", "l": "Phosphorylation of STAT1 at Ser727 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32817", "l": "Hg(2+)(out) => Hg(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38760", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.106", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15247", "l": "a fatty acid + glycerol + H(+) => a monoacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0008516", "l": "hexose uniporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9626914", "l": "α2-agonists bind ADRA2A,B,C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30485", "l": "H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205321", "l": "Interaction of KIT and sSCF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53865", "l": "3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+) => 7,12-dioxo-lithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59490", "l": "ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate => ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58807", "l": "5'-pApG-3' + H2O <=> 5'-ApG-3' + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34977", "l": "(R)-pantothenate(out) => (R)-pantothenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607733", "l": "BCL10 binds CARD9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201685", "l": "Beta-catenin is released from the destruction complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15554", "l": "1D-myo-inositol 1,4-bisphosphate + H2O => 1D-myo-inositol 4-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63357", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2 => (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0097027", "l": "ubiquitin-protein transferase activator activity", "d": ["Binds to and increases the activity of a ubiquitin-protein transferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67030", "l": "(glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate => (glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1297275", "l": "CD9:Izumo Binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47332", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47170", "l": "4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73757", "l": "Binding of RRN3 to RNA Polymerase I (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73711", "l": "ATP(in) + UTP(out) = ATP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20343", "l": "1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP => sn-glycerol 3-phosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509831", "l": "ITPA hydrolyses XTP to XMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50435", "l": "AH2 + prostaglandin G1 <=> A + H2O + prostaglandin H1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48520", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol", "d": []}, {"i": "EC:3.1.1.n2", "l": "\"protein-S-isoprenylcysteine alpha-carbonyl methylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73792", "l": "dimethylallyl diphosphate + neoechinulin A => diphosphate + variecolorin G", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58367", "l": "a medium-chain primary fatty alcohol + NADP(+) <=> a medium-chain fatty aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38197", "l": "estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082356", "l": "HSF1-mediated gene expression (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102649", "l": "acetoacetyl-ACP synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + malonyl-CoA + H+ + a holo-[acyl-carrier protein] <=> acetoacetyl-ACP + 2 coenzyme A + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450488", "l": "BRF1 Complex recruits RNA degradation activities (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391211", "l": "Trace amine-associated receptors can bind trace amines (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67269", "l": "(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate => sch 210972", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034576", "l": "N-isopropylacetanilide amidohydrolase activity", "d": ["Catalysis of the reaction: N-isopropylacetanilide + OH- = N-isopropylaniline + acetate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050446", "l": "azobenzene reductase activity", "d": ["Catalysis of the reaction: N,N-dimethyl-1,4-phenylenediamine + aniline + NADP+ = 4-(dimethylamino)azobenzene + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187506", "l": "Translocation of p27 to the nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801109", "l": "CHM binds RGGT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654511", "l": "FGFRL1 dimer binds FGFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66390", "l": "ADP + H(+) + phosphate + prostaglandin E2(out) => ATP + H2O + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59063", "l": "(20S)-ginsenoside Rg3 + H2O <=> (20S)-ginsenoside Rh2 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68152", "l": "a 1,3-diacylglycerol + a fatty acyl-CoA = a triacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30143", "l": "H2O + octanoyl-CoA = CoA + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68100", "l": "NAD(+) + xylitol = H(+) + L-xylulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67930", "l": "a 3'-end 3'-phosphouridine-RNA + H(+) => a 3'-end 2',3'-cyclophospho-uridine-RNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35098", "l": "choline <=> acetaldehyde + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65537", "l": "1,3,7-trimethylurate + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + theacrine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203613", "l": "depalmitoylation of eNOS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444433", "l": "Cho transports from the extracellular space to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034842", "l": "thiophene-2-carboxylate-CoA ligase activity", "d": ["Catalysis of the reaction: thiophene-2-carboxylate + ATP + CoASH = thiophene-2-carboxyl-CoA + AMP + PPi."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015052", "l": "beta3-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418865", "l": "Recruitment of ABLIM to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212356", "l": "Formation of CSL-NICD coactivator complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15719", "l": "doxorubicin + H2O + NADP(+) => daunorubicin + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35071", "l": "4-methylphenol(in) = 4-methylphenol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57789", "l": "1,3-dinitrobenzene + NADH + O2 => 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20511", "l": "ADP + H(+) + O-phosphoviomycin => ATP + viomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39013", "l": "a triacyl-sn-glycerol(out) => a triacyl-sn-glycerol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56270", "l": "CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031073", "l": "cholesterol 26-hydroxylase activity", "d": ["Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16233", "l": "(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.169", "l": "\"2-dehydropantoate 2-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4093332", "l": "p-EPHB phosphorylates SDC2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75850", "l": "9-cis-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-cis-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672011", "l": "p-AMPK:AMP binds the ULK complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74479", "l": "(-)-cyclopeptine + 2-oxoglutarate + O2 = (Z)-dehydrocyclopeptine + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44711", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41777", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0) => CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62356", "l": "8-oxo-GDP + H2O = 8-oxo-GMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.48", "l": "\"heteroglycan alpha-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372542", "l": "Loading of dopamine into synaptic veiscles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196964", "l": "RFK:Mg2+ phosphorylates RIB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72095", "l": "Internal Methylation of mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11514", "l": "H(+) + salicin + UDP => salicyl alcohol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61828", "l": "stigmasterol + UDP-alpha-D-glucose = H(+) + stigmasteryl 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21617", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050123", "l": "N-acylmannosamine 1-dehydrogenase activity", "d": ["Catalysis of the reaction: N-acyl-D-mannosamine + NAD+ = N-acyl-D-mannosaminolactone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0003964", "l": "RNA-directed DNA polymerase activity", "d": ["Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16183", "l": "3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69299", "l": "CDT1 binds geminin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71692", "l": "glycyl-L-glutamate(out) + 2 H(+)(out) => glycyl-L-glutamate(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56333", "l": "5'-triphosphoadenylyl-(2'->5')-adenosine + H2O => AMP + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45664", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18300", "l": "a phtalamide + H2O <=> a primary amine + phthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64930", "l": "dAMP + H(+) + phosphate => dADP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689649", "l": "BAP1 binds BRCA1:BARD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009018", "l": "sucrose phosphorylase activity", "d": ["Catalysis of the reaction: sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614461", "l": "Tetramerization of procollagen VI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21910", "l": "H(+) + NADPH + naphthalene-1,3,6,8-tetrol => NADP(+) + scytalone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417842", "l": "P2Y10 receptor can bind to LPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009007", "l": "site-specific DNA-methyltransferase (adenine-specific) activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10292", "l": "acetyl-CoA + D-glucosamine 6-phosphate = CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}, {"i": "EC:2.3.1.4", "l": "\"glucosamine-phosphate N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5226979", "l": "ADD1:ADD2 binds DMTN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63095", "l": "H(+) + ilicicolin A + NADPH + O2 <=> H2O + ilicicolin A epoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34773", "l": "a 3-oxosteroid + CO2 + NADPH => a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0005153", "l": "interleukin-8 receptor binding", "d": ["Binding to an interleukin-8 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112434", "l": "Formation of DSIF complex  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29876", "l": "H2O + sn-glycero-3-phospho-L-serine => H(+) + L-serine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50806", "l": "prostaglandin J2-S-(R)-glutathione => glutathione + prostaglandin J2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68508", "l": "(2E,6E)-farnesyl diphosphate = (Z)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933538", "l": "Recruitment of IRF7 to TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850997", "l": "TRIM27 binds PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41095", "l": "H2O + sphing-4-enine-phosphocholine = H(+) + phosphocholine + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018471", "l": "4-chlorobenzaldehyde oxidase activity", "d": ["Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678854", "l": "S1PR1 binds S1PR1 agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696465", "l": "USP45 deubiquitinates ERCC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47604", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) = CMP + ganglioside GP1calpha (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805205", "l": "GPR35 binds kynurenic acid (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790454", "l": "SUMOylation of XPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20402", "l": "a beta-lactam + H2O => a substituted beta-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25761", "l": "diphosphate + ent-isokaurene => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27517", "l": "H2O + sphinganine 1-phosphate <=> phosphate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22620", "l": "H(+) + L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH4(+)", "d": []}, {"i": "EC:1.13.99.3", "l": "\"tryptophan 2'-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163625", "l": "Glucagon binds to Glucagon receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48381", "l": "alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75575", "l": "11-O-acetylcyathatriol + A = 11-O-acetylcyathin A3 + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2430535", "l": "MASTL phosphorylates ENSA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69630", "l": "N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0003983", "l": "UTP:glucose-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11103", "l": "4-hydroxyhexan-3-one <=> 2 propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58690", "l": "H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide => NADH + O2 + rifamycin SV", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44694", "l": "CoA + H(+) + N-acylhexadecasphinganine => a fatty acyl-CoA + hexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799441", "l": "TP53 stimulates expression of the TP53I3 (PIG3) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849094", "l": "ARHGAP35 binds RASA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660015", "l": "Defective RPIA does not isomerize R5P to RU5P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17029", "l": "(S)-allantoin + H2O = allantoate + H(+)", "d": []}, {"i": "EC:3.5.2.5", "l": "\"allantoinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55125", "l": "(2E)-5-methylhexenoyl-[ACP] + H(+) + NADH => 5-methylhexanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46321", "l": "3beta-hydroxy-chol-5-ene-24-oyl-CoA + A => 3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11707", "l": "2 H(+) + N-(carboxyaminomethyl)urea <=> CO2 + N-(aminomethyl)urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38740", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678920", "l": "TLR processing at low pH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018596", "l": "dimethylsilanediol hydroxylase activity", "d": ["Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417842", "l": "P2Y10 receptor can bind to LPA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44880", "l": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102632", "l": "(S)-nandinine synthase activity", "d": ["Catalysis of the reaction: (S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-nandinine + [oxidized NADPH--hemoprotein reductase] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49137", "l": "H(+) + L-methionyl-[protein] + NADPH + O2 => H2O + L-methionyl-S-oxide-[protein] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635854", "l": "GLI2,3 are degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74303", "l": "12alpha-hydroxy-3-oxochola-4-en-24-oate + NAD(+) = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41292", "l": "H2O + N-dodecanoylsphing-4-enine => dodecanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390846", "l": "D2D3,4 bind to DA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190260", "l": "FGFR2b binds to FGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67704", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199299", "l": "AKT phosphorylates FOXO transcription factors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41060", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18611", "l": "H(+) + N(2)-acetyl-L-citrulline + phosphate => carbamoyl phosphate + N(2)-acetyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984994", "l": "RUNX2 binds MAF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0002060", "l": "purine nucleobase binding", "d": ["Binding to a purine nucleobase, an organic nitrogenous base with a purine skeleton."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421835", "l": "trans-Golgi Network Vesicle Scission (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706304", "l": "Active FLT3 binds to GRAP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864466", "l": "TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64064", "l": "(1R,2R)-pseudoephedrine + NAD(+) = (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507871", "l": "Aquaporins passively transport glycerol out of cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070773", "l": "protein-N-terminal glutamine amidohydrolase activity", "d": ["Catalysis of the reaction: N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH3. This reaction is the deamidation of an N-terminal glutamine residue of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2430535", "l": "MASTL phosphorylates ENSA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11412", "l": "6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)", "d": []}, {"i": "EC:2.7.6.3", "l": "\"2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51524", "l": "(S)-corytuberine + S-adenosyl-L-methionine = magnoflorine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791109", "l": "GADD45A binds PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54782", "l": "[LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide => [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43917", "l": "(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050564", "l": "N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity", "d": ["Catalysis of the reaction: L-2-aminoadipate + L-cysteine + L-valine + 3 ATP + H2O = N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 6 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202437", "l": "Phosphorylation of CARMA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53641", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-amorphene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031843", "l": "type 2 neuropeptide Y receptor binding", "d": ["Binding to a type 2 neuropeptide Y receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13784", "l": "an L-alpha-amino acid + H2O + O2 <=> a 2-oxocarboxylate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953339", "l": "DNPH1 hydrolyses dGMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25275", "l": "ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate => ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044693", "l": "trehalose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: trehalose(out) + H+(out) = trehalose(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38283", "l": "itaconate + succinyl-CoA = itaconyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23054", "l": "ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] => ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0008297", "l": "single-stranded DNA exodeoxyribonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19121", "l": "an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate", "d": []}, {"i": "EC:7.6.2.3", "l": "\"ABC-type glutathione-S-conjugate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36898", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.124", "l": "\"protein deglycase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23467", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66284", "l": "tomatidine + UDP-alpha-D-glucose = H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869580", "l": "DEK binds TFAP2A homodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19101", "l": "2-butyne-1,4-diol + NAD(+) = 4-hydroxy-2-butynal + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.165", "l": "\"2-alkyn-1-ol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72510", "l": "2-oxoglutarate(in) + prostaglandin F2alpha(out) <=> 2-oxoglutarate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169406", "l": "ISGylation of host proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874218", "l": "CREB3L4 translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683792", "l": "p-T68-CHEK2 autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004474", "l": "malate synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785762", "l": "IL13RA1 binds TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917841", "l": "Acidification of Tf:TfR1 containing endosome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6813749", "l": "ALDH1A1 oxidises GA to DGA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75811", "l": "acetoacetate(out) + Na(+)(out) = acetoacetate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44272", "l": "3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA = 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044717", "l": "8-hydroxy-dADP phosphatase activity", "d": ["Catalysis of the reaction: 8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate."]}, {"i": "REACT:R-HSA-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018720", "l": "phenol kinase activity", "d": ["Catalysis of the reaction: phenol + X-HPO3- = XH + phenylphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67653", "l": "dADP + H2O => 2'-deoxyadenosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38180", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63228", "l": "ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10825", "l": "(S)-malate + NADP(+) => H(+) + NADPH + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917700", "l": "MVB Vesicle Formation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69615", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30598", "l": "4-hydroxyphenylacetate + FADH2 + O2 <=> 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9689680", "l": "IFNG dimer binds IFNG inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665748", "l": "FMNL2 binds RHOC:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418856", "l": "Activation of Rac1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67889", "l": "3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine => 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0032559", "l": "adenyl ribonucleotide binding", "d": ["Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0071207", "l": "histone pre-mRNA stem-loop binding", "d": ["Binding to a conserved stem-loop structure found in histone pre-mRNAs."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66963", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose <=> beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74120", "l": "delphinidin + UDP-alpha-D-galactose => delphinidin 3-O-beta-D-galactoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53437", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26011", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) => 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58257", "l": "H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] => ADP-D-ribose + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9640167", "l": "RRAGA,B exchanges GDP for GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55332", "l": "a 3'-hydroxyflavone + S-adenosyl-L-methionine = a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374664", "l": "Phosphorylation and activation of Ezrin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635842", "l": "ULK3 phosphorylates GLI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23425", "l": "alpha-D-glucosamine 1-phosphate => D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37825", "l": "2,4-dichlorophenol + CO2 + pyruvate + succinate => (R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004337", "l": "geranyltranstransferase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66771", "l": "ATP + coproporphyrin I(in) + H2O <=> ADP + coproporphyrin I(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40475", "l": "1,2,3-tributanoylglycerol + H2O = butanoate + dibutanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35997", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3814820", "l": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19983", "l": "H(+) + NADPH + S-formylglutathione => NADP(+) + S-(hydroxymethyl)glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55907", "l": "7-chloro-L-tryptophan + chloride + FADH2 + O2 <=> 6,7-dichloro-L-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65743", "l": "2-oxoglutarate + nonyl sufate + O2 <=> CO2 + H(+) + nonanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28626", "l": "(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39546", "l": "3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54216", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047633", "l": "agmatine kinase activity", "d": ["Catalysis of the reaction: agmatine + ATP = N(4)-phosphoagmatine + ADP + 3 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31638", "l": "beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55560", "l": "a hydroperoxyeicosatetraenoate = a hydroxy-epoxy-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167429", "l": "The receptor:G-protein complex  binds GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18378", "l": "ATP + streptomycin => ADP + H(+) + streptomycin 3''-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156930", "l": "GTP-binding activates eEF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19742", "l": "formyl-CoA + H2O => CoA + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52695", "l": "3-phenyllactate + NADP(+) <=> 3-phenylpyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19182", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034618", "l": "arginine binding", "d": ["Binding to 2-amino-5-(carbamimidamido)pentanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15891", "l": "L-glutamate + NH4(+) => H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803063", "l": "RNASEs bind bacterial LPS, PGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052933", "l": "alcohol dehydrogenase (cytochrome c(L)) activity", "d": ["Catalysis of the reaction: 2 [Fe(III)cytochrome cL] + a primary alcohol = 2 [Fe(II)cytochrome cL] + an aldehyde + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052626", "l": "benzoate amino acid synthetase activity", "d": ["Catalysis of the reaction: benzoate + ATP + amino acid = benzoyl amino acid conjugate + AMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008668", "l": "(2,3-dihydroxybenzoyl)adenylate synthase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxybenzoate + ATP = 2,3-dihydroxybenzoyl 5'-adenylate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9670114", "l": "Histone H3.3 deposition at telomere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982645", "l": "GRKs bind ADRB2:Catecholamine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39286", "l": "a long-chain fatty acid(out) <=> a long-chain fatty acid(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10804", "l": "(S)-allantoin = (R)-allantoin", "d": []}, {"i": "EC:5.1.99.3", "l": "\"allantoin racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44178", "l": "3-acyl-sn-glycerol + a fatty acid + H(+) => a 2,3-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821931", "l": "BOD1L1 binds SET1A complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49804", "l": "2-methylpropan-1-amine + FMNH2 + O2 = FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.52", "l": "\"diphosphoinositol-polyphosphate diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690877", "l": "Expression of DMRT1 in testis differentiation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28341", "l": "(R)-carnitinyl-CoA <=> crotonobetainyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26488", "l": "L-cysteate + phosphate => H(+) + O-phospho-L-serine + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36526", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA <=> (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2167942", "l": "Collagen type XIII ectodomain shedding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13889", "l": "FAD + H2O = AMP + FMN + 2 H(+)", "d": []}, {"i": "EC:3.6.1.18", "l": "\"FAD diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39442", "l": "(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA <=> (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54180", "l": "a long-chain fatty aldehyde + holo-[ACP] + NAD(+) = a long-chain fatty acyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39261", "l": "(2E,13Z)-docosadienoyl-CoA + H2O => (3R)-hydroxy-(13Z)-docosenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40788", "l": "H2O + tetracosanoyl-CoA => CoA + H(+) + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.23.-.-", "l": "\"Reducing C-O-C group as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177926", "l": "Dephosphorylation of PAG by SHP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64635", "l": "acetyl-CoA + butan-1-ol <=> butyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855111", "l": "VLDLR binds PCSK9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42844", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH = 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide", "d": []}, {"i": "EC:2.3.1.240", "l": "\"narbonolide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44903", "l": "D-galactono-1,4-lactone + H2O <=> D-galactonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74174", "l": "an N-methyl carbamate ester + H(+) + H2O <=> an alcohol + CO2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684352", "l": "nsp3-4 cleaves itself (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54114", "l": "diphosphate + selina-4(15),7(11)-diene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016018", "l": "cyclosporin A binding", "d": ["Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655483", "l": "USP1 autocleavage (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170149", "l": "Translocation of active Cdc25C to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43329", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022453", "l": "MECP2 binds 5hmC-DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68049", "l": "[protein]-D-aspartate + S-adenosyl-L-methionine => [protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9006870", "l": "IL21 receptor STAT phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53069", "l": "4-methoxyestrone + UDP-alpha-D-glucuronate => 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75438", "l": "32-oxoeburicol + O2 + reduced [NADPH--hemoprotein reductase] <=> 14-demethyleburicol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209973", "l": "Tyrosine is diiodinated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69135", "l": "cadaverine + H2O + O2 <=> 5-aminopentanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12905", "l": "alpha-D-mannose 1-phosphate + GDP + H(+) = GDP-alpha-D-mannose + phosphate", "d": []}, {"i": "EC:2.7.7.22", "l": "\"mannose-1-phosphate guanylyltransferase (GDP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977629", "l": "Displacement of C2a/Bb by CR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198983", "l": "NKG2D homodimer interacting with ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.-.-", "l": "\"Catalysing the translocation of other compounds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944262", "l": "Association of procollagen type X (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110307", "l": "REV1 binds AP-dsDNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703441", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956659", "l": "ABL1 phosphorylates YAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60527", "l": "5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48238", "l": "1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+) => 2 2-acetylphloroglucinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41453", "l": "5-methyl-1-naphthoate + H(+) + NADPH + O2 => 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788668", "l": "TRMT13 2'-O-methylates adenosine-4 in tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50089", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863472", "l": "DAB2 binds LRP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019174", "l": "tetrahydrothiophene 1-oxide reductase activity", "d": ["Catalysis of the reaction: tetrahydrothiophene 1-oxide + reduced acceptor = tetrahydrothiophene + acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51910", "l": "dADP + H(+) + phosphate => dATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10268", "l": "2-dehydro-3-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate", "d": []}, {"i": "EC:4.1.2.20", "l": "\"2-dehydro-3-deoxyglucarate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58748", "l": "desmethylnectriapyrone + S-adenosyl-L-methionine = H(+) + nectriapyrone + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33051", "l": "choline + NAD(+) = betaine aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33771", "l": "a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65795", "l": "fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5333051", "l": "RPA1 binds HSF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9639698", "l": "ROS positively regulates misfolding of cilia proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418662", "l": "Src activation following P2Y purinoceptor activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442405", "l": "hZIP5 mediates zinc uptake by cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71269", "l": "chloride(in) + L-pipecolate(in) + 2 Na(+)(in) => chloride(out) + L-pipecolate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.53", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28741", "l": "Cd(2+)(out) + H(+)(in) => Cd(2+)(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050573", "l": "dTDP-4-dehydro-6-deoxyglucose reductase activity", "d": ["Catalysis of the reaction: dTDP-D-fucose + NADP+ = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15877", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate = D-glutamate + pyridoxal 5'-phosphate", "d": []}, {"i": "EC:2.6.1.54", "l": "\"pyridoxamine-phosphate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39061", "l": "26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71783", "l": "MDH2 reduces OA to MAL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847534", "l": "RAB43 hydrolyses GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70689", "l": "4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in) => 4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080104", "l": "5-methylthiopropyl glucosinolate S-oxygenase activity", "d": ["Catalysis of the reaction: 5-methylthiopropyl-glucosinolate = 5-methylsulfinylpropyl-glucosinolate."]}]}
{"type": "biolink:MolecularActivity", "ic": "77.264511229695032", "identifiers": [{"i": "GO:0061650", "l": "ubiquitin-like protein conjugating enzyme activity", "d": ["Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction X-SCP + Y = Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36047", "l": "A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H(+)", "d": []}, {"i": "EC:1.2.99.8", "l": "\"glyceraldehyde dehydrogenase (FAD-containing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66756", "l": "ATP + domoate(in) + H2O = ADP + domoate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176517", "l": "SULTs transfer (SO4)2- group to PREG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60211", "l": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 <=> 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862184", "l": "USP48 cleaves polyubiquitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717395", "l": "TRPM5 transports Na+ from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57699", "l": "ATP + cob(I)inamide-[corrinoid adenosyltransferase] <=> adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51974", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60108", "l": "(R)-3-(4-hydroxyphenyl)lactoyl-CoA = (E)-4-coumaroyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839094", "l": "Activated FGFR1 mutants and fusions bind PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690997", "l": "Ligation of newly synthesized repair patch to incised DNA in GG-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14698", "l": "(2E,6E)-farnesol + NADP(+) => (2E,6E)-farnesal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49509", "l": "phosphinomethylmalate => 2-(phosphinatomethylidene)butanedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55744", "l": "coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.8.98.4", "l": "\"coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607740", "l": "PKC-delta phosphorylates CARD9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.200", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40791", "l": "H2O + hexacosanoyl-CoA = CoA + H(+) + hexacosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56463", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391168", "l": "SIRP gamma binds CD47 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41477", "l": "an acyl-CoA + zymosterol => CoA + zymosterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.61", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634861", "l": "NPAS4 binds ARNT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66878", "l": "12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604360", "l": "Initial activation of proMMP2 by MMP14 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67255", "l": "H2O + malonaldehyde + NAD(+) <=> 3-oxopropanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0010354", "l": "homogentisate prenyltransferase activity", "d": ["Catalysis of the transfer of a prenyl group from one compound (donor) to homogentisic acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102966", "l": "arachidoyl-CoA:1-dodecanol O-acyltransferase activity", "d": ["Catalysis of the reaction: icosanoyl-CoA + dodecan-1-ol = arachidoyl dodecanoate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264458", "l": "Proteasome mediated degradation of COP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823729", "l": "Expression of SOX17 in definitive endoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30041", "l": "benzene-1,2,4-triol + CO2 + H2O + NADP(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0015038", "l": "glutathione disulfide oxidoreductase activity", "d": ["Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor."]}, {"i": "REACT:R-HSA-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417908", "l": "P2RY1 binds ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66302", "l": "an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+) => an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956568", "l": "RUNX1 binds the core TAL1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.-", "l": "\"Cysteine endopeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48029", "l": "H2O + triacetin => acetate + diacetylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-481009", "l": "Exocytosis of platelet dense granule content (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21653", "l": "2-chlorobenzoate + H(+) + NADH + O2 => catechol + chloride + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73682", "l": "3'-AMP(in) + ADP(out) + H(+)(out) <=> 3'-AMP(out) + ADP(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190829", "l": "Lysosomal degradation of gap junction plaques (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102291", "l": "11alpha-hydroxy-beta-amyrin dehydrogenase activity", "d": ["Catalysis of the reaction: 11alpha-hydroxy-beta-amyrin + O2 + NADPH + H+ = 11-oxo-beta-amyrin + 2 H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645137", "l": "Activator phosphorylates STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13272", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O <=> an N-acylsphing-4-enine + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13841", "l": "Fe(II)2-[transferrin] + H(+) + NAD(+) = Fe(III)2-[transferrin] + NADH", "d": []}, {"i": "EC:1.16.1.2", "l": "\"diferric-transferrin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69061", "l": "N(delta)-hydroxy-N(omega)-methyl-L-arginine + NADH + O2 => H2O + N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54491", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.107", "l": "\"limonene 1,2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11304", "l": "(S)-ureidoglycolate = glyoxylate + urea", "d": []}, {"i": "EC:4.3.2.3", "l": "\"ureidoglycolate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0043022", "l": "ribosome binding", "d": ["Binding to a ribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40131", "l": "(9Z)-hexadecenoyl-CoA + H2O = (9Z)-hexadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58891", "l": "4-aminobenzoate + AH2 + 2 O2 <=> 4-nitrobenzoate + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627106", "l": "SMAC (DIABLO) forms dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912372", "l": "Fringe-modified Pre-NOTCH is cleaved by FURIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51962", "l": "2-methylpropanenitrile + H2O => (Z)-2-methylpropanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661432", "l": "BIL binds ALB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008140", "l": "cAMP response element binding protein binding", "d": ["Binding to a cAMP response element binding protein (a CREB protein)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57966", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71691", "l": "glycyl-L-glutamate(out) + 2 H(+)(out) = glycyl-L-glutamate(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955885", "l": "SOCS3 gene expression is inhibited by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620837", "l": "CCNG2 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033791", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity", "d": ["Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62410", "l": "1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine => 3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74645", "l": "CMP-N-acetyl-beta-neuraminate(out) + UMP(in) => CMP-N-acetyl-beta-neuraminate(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24661", "l": "H(+) + L-arginine + NADPH + O2 => H2O + N(omega)-hydroxy-L-arginine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38001", "l": "H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine => 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876789", "l": "CARNMT1 methylates CARN to Anserine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56640", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74711", "l": "Phosphorylation of IRS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41685", "l": "1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O => 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37487", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46908", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21173", "l": "L-idonate + NAD(+) => 5-dehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168092", "l": "Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004658", "l": "propionyl-CoA carboxylase activity", "d": ["Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.57", "l": "\"leucyl endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27817", "l": "acetate(in) + Na(+)(in) <=> acetate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18595", "l": "hexadecanal + phosphoethanolamine => sphinganine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848939", "l": "PTK6 binds KHDRBS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64580", "l": "(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + nerylneryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58824", "l": "4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.37", "l": "\"luteothin monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12487", "l": "a ribonucleoside 5'-phosphate + H2O <=> a ribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018854", "l": "3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity", "d": ["Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451310", "l": "Activation of Edited Kainate receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.264511229695032", "identifiers": [{"i": "GO:0004529", "l": "DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25297", "l": "acetaldehyde + H2O + NAD(+) <=> acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62935", "l": "H2O + N(4)-acetylcytidine <=> acetate + cytidine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-606349", "l": "Mis18 complex binds the centromere (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1299318", "l": "Activation of TASK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964471", "l": "DREAM complex binds the CDC25A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798282", "l": "TP53 and E2F4 bind the CDC25C gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2327733", "l": "FN1 binds Collagen types I-V, VII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210881", "l": "Dimerization of Tie2/Ang1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31314", "l": "(2R)-3-phosphoglycerate + ADP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982810", "l": "JAK2 phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1008200", "l": "NFE2 binds the beta globin locus control region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23600", "l": "2-oxoglutarate + L-2-aminohexanoate = 2-oxohexanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.67", "l": "\"2-aminohexanoate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177934", "l": "EGFR autophosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052716", "l": "hydroquinone:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: 4 hydroquinone + O2 = 4 benzosemiquinone + 4 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044025", "l": "histone H2BS14 kinase activity", "d": ["Catalysis of the reaction: histone H2B-serine (position 14) + ATP = histone H2B-phosphoserine (position 14) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 14 of histone H2B."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46393", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951500", "l": "Dissociation of CANX from nonameric complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140842", "l": "n fibrin monomers -> fibrin multimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879562", "l": "SLCO2B1 has a narrow substrate specificity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59277", "l": "L-glutamine => D-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15640", "l": "[alginate](n) + GDP-alpha-D-mannuronate <=> [alginate](n+1) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15078", "l": "H(+) + N-[(R)-pantothenoyl]-L-cysteine => (R)-pantetheine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141691", "l": "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57992", "l": "(20S)-ginsenoside C-K + UDP-alpha-D-glucose = (20S)-ginsenoside F2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22251", "l": "7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) <=> 7,8-dihydroxykynurenate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35199", "l": "(S,S)-tartrate(out) = (S,S)-tartrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25704", "l": "H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603379", "l": "TPMT does not transfer CH3 from AdoMet to 6MP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41747", "l": "3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol <=> a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40050", "l": "1,2,3-trioctanoylglycerol + H2O <=> 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6795460", "l": "SGK1 phosphorylates MDM2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61424", "l": "cis-cis-nepetalactol + NAD(+) = cis-cis-nepetalactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62429", "l": "3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA => 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55683", "l": "(2S)-2-amino-4-deoxychorismate <=> anthranilate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0030371", "l": "translation repressor activity", "d": ["Antagonizes ribosome-mediated translation of mRNA into a polypeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909718", "l": "Formation of p-STAT1 homodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32408", "l": "(1R,2S,4S)-neoisodihydrocarveol + NAD(+) => (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25957", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) => 3-dehydroquinate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31382", "l": "H2O + pyrrole-2-carboxylate <=> 1H-pyrrole + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43427", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201622", "l": "Caspase-mediated cleavage of gelsolin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21095", "l": "12-hydroxydihydrochelirubine + S-adenosyl-L-methionine <=> dihydromacarpine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34731", "l": "15-methylhexadecasphing-4-enine + a fatty acyl-CoA = CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102399", "l": "dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose <=> S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202459", "l": "Phosphorylation of Bcl10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244397", "l": "botB HC:LC binds SYT1 or 2 and GT1b on the target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392530", "l": "p-S400-Cot phosphorylates NIK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57637", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate => holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033960", "l": "N-methyl nucleosidase activity", "d": ["Catalysis of the reaction: 7-methylxanthosine + H2O = 7-methylxanthine + H+ + ribofuranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266303", "l": "Spherical HDL binds C and E apolipoproteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70686", "l": "(R)-normetanephrine + S-adenosyl-L-methionine <=> (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202164", "l": "Translocation of PDK1 to Plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43353", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18066", "l": "ATP + H2O + phosphonate(out) => ADP + H(+) + phosphate + phosphonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786421", "l": "CHIA hydrolyses chitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69797", "l": "D-aspartate + H(+) + tRNA(Asp) => D-aspartyl-tRNA(Asp) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23807", "l": "N-acetyl-alpha-D-glucosamine 1-phosphate <=> N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928646", "l": "EPHAs bind EFNAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59675", "l": "D-maltotriose + O2 <=> D-maltotriono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956659", "l": "ABL1 phosphorylates YAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71167", "l": "glycine(out) + H(+)(in) + Na(+)(out) = glycine(in) + H(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47191", "l": "Co(I)-[methylated-thiol-specific corrinoid protein] + methanethiol <=> hydrogen sulfide + methyl-Co(III)-[methylated-thiol-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39514", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA <=> (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371435", "l": "Constitutive phosphorylation by GSK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14490", "l": "a nucleoside 2',3'-cyclic phosphate + H2O => a nucleoside 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59695", "l": "D-cellotriono-1,5-lactone + H2O <=> D-cellotrionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38288", "l": "(3S)-citramalate + succinyl-CoA => (3S)-citramalyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18133", "l": "ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate", "d": []}, {"i": "EC:2.7.7.4", "l": "\"sulfate adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050272", "l": "S-carboxymethylcysteine synthase activity", "d": ["Catalysis of the reaction: 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59718", "l": "D-maltopentaonate + H(+) => D-maltopentaono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39344", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA => (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44468", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956676", "l": "YAP1 binds TP73 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061821", "l": "telomeric D-loop binding", "d": ["Binding to a telomeric D-loop. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191656", "l": "Closure of gap junction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13888", "l": "H2O + stipitatonate <=> CO2 + stipitatate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.35", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64139", "l": "H2O + N-(9Z-octadecenoyl)-L-asparagine <=> (9Z)-octadecenoate + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52556", "l": "3-dehydro-D-erythronate + ATP = 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45403", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62561", "l": "(4R)-limonene + A + H2O => (4R)-perillyl alcohol + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.71", "l": "\"endothelin-converting enzyme 1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-877187", "l": "P2X7 mediates loss of intracellular K+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37054", "l": "3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804229", "l": "JMY, TTC5 and EP300 bind (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203611", "l": "N-myristoylation of eNOS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.17", "l": "\"inulin fructotransferase (DFA-I-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64800", "l": "NAD(+) + S-(2-aminoethyl)-L-cysteine = (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14493", "l": "H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] = ADP-D-ribose + L-arginyl-[dinitrogen reductase]", "d": []}, {"i": "EC:3.2.2.24", "l": "\"ADP-ribosyl-[dinitrogen reductase] hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68270", "l": "dTMP + H2O + NADP(+) => dUMP + formaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21561", "l": "3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol => 1,4-dithiothreitol + 2,3-epoxyphylloquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626938", "l": "Beta-catenin binds SOX proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12978", "l": "H2O + N-phosphocreatine => creatine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669158", "l": "NF2 binds PAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9612219", "l": "ERBB4s80 binds to SRC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14193", "l": "3-hydroxybenzoate + AH2 + O2 = 2,3-dihydroxybenzoate + A + H2O", "d": []}, {"i": "EC:1.14.99.23", "l": "\"3-hydroxybenzoate 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45647", "l": "H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-hexadecanoylsphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43487", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421831", "l": "trans-Golgi Network Coat Assembly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11986", "l": "A + H2O + testosterone acetate => AH2 + O2 + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44721", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O => a 1-acyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71153", "l": "(E)-caffeoylpyruvate + CO2 + hnu => 4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322431", "l": "XIAP binds TLE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37963", "l": "galactitol + NAD(+) = D-galactose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33682", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1977959", "l": "ERBB4 forms heterodimers with EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951951", "l": "RUNX3 binds EP300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641111", "l": "Parkin transfers Ub to misfolded proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33544", "l": "ergosteryl palmitate + H2O => ergosterol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74129", "l": "peonidin 3-O-beta-D-galactoside + UDP => peonidin + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031510", "l": "Expression of APOC1 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47320", "l": "(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate = 3-oxo-3-phenylpropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20417", "l": "coelenterazine + O2 = CO2 + coelenteramide + hnu", "d": []}, {"i": "EC:1.13.12.13", "l": "\"Oplophorus-luciferin 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47255", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54073", "l": "(2E)-geranyl diphosphate => beta-thujene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60811", "l": "gibberellin A19 + H(+) + O2 <=> CO2 + gibberellin A20 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.385", "l": "\"sterol 27-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25715", "l": "N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19605", "l": "a chlorophyll + H2O = a chlorophyllide + H(+) + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75399", "l": "2 H(+)(out) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(out) = 2 H(+)(in) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800836", "l": "TP53 or TP63 binds the PERP gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45637", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17864", "l": "21-hydroxyprogesterone <=> 20-hydroxy-3-oxopregn-4-en-21-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44563", "l": "4-hydroxybenzoate + all-trans-heptaprenyl diphosphate <=> 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41859", "l": "3-oxodecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxydecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22941", "l": "ATP + L-arginine => ADP + H(+) + N(omega)-phospho-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.139", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989775", "l": "Expression of SULT2A1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428750", "l": "Gq activation by TP receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53989", "l": "H2O + O-phospho-L-threonyl-[myosin light chain] => L-threonyl-[myosin light chain] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043767", "l": "pyrrolysyl-tRNA synthetase activity", "d": ["Catalysis of the reaction: ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41871", "l": "decanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102658", "l": "2-oxo-5-methylthiopentanoate aminotransferase activity", "d": ["Catalysis of the reaction: 5-methylthio-2-oxopentanoate + a standard alpha amino acid <=> L-homomethionine + a 2-oxo carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26209", "l": "L-allo-threonine = acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55073", "l": "2-oxobutanoate + H(+) => CO2 + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49023", "l": "2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14253", "l": "guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16361", "l": "2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36342", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9612219", "l": "ERBB4s80 binds to SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38403", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559414", "l": "Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59237", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + isoelisabethatriene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668735", "l": "RAC1:GTP binds NOX3 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67252", "l": "H2O + malonaldehyde + NAD(+) = 3-oxopropanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47073", "l": "1-eicosanoylglycerol + H2O => eicosanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28415", "l": "gamma-L-glutamylputrescine + H2O + O2 => 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021451", "l": "NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45754", "l": "(2E)-decenoyl-CoA => (3E)-decenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47215", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418858", "l": "RhoGTPase GEF's recruited to DCC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37411", "l": "aklavinone + NADP(+) = aklaviketone + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.362", "l": "\"aklaviketone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54429", "l": "4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O => ADP-D-ribose + H(+) + L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193646", "l": "NGF binding to p75NTR inactivates RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202168", "l": "Phosphorylation of ZAP-70 by Lck (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74707", "l": "Binding of IRS to insulin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195378", "l": "Homodimerization of VEGF proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41086", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75079", "l": "Formation of AT-AC C complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62764", "l": "4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858435", "l": "TSPAN7 binds PICK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19150", "l": "L-arginyl-[protein] + NAD(+) => H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73580", "l": "(E,E)-piperoyl-AMP + CoA => (E,E)-piperoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61308", "l": "(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37343", "l": "adenosine 2'-phosphate + H2O = adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44347", "l": "ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide A + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446364", "l": "Migfilin interacts with VASP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090542", "l": "ELYC domain binding", "d": ["Binding to a ELYC protein domain. The ELYC domain is an approximately 150 amino acid sequence which contains a highly conserved tetrapeptide sequence, ELYC."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72647", "l": "Cap-bound mRNA is activated by helicases  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602063", "l": "Defective CYP26B1 does not 4-hydroxylate atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11036", "l": "a quaternary ammonium(out) + ATP + H2O = a quaternary ammonium(in) + ADP + H(+) + phosphate", "d": []}, {"i": "EC:7.6.2.9", "l": "\"ABC-type quaternary amine transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11263", "l": "H(+) + NADPH + O2 <=> H2O2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170120", "l": "Translocation of Cdc25B to the cytoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69575", "l": "dIMP + inosine <=> 2'-deoxyinosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67973", "l": "ATP + ecdysone => ADP + ecdysone 22-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73798", "l": "dimethylallyl diphosphate + neoechinulin A <=> diphosphate + isoechinulin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73335", "l": "ATP + beta-alanine + tryptamine = AMP + beta-alanyl-tryptamine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015451", "l": "decarboxylation-driven active transmembrane transporter activity", "d": ["Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74711", "l": "Phosphorylation of IRS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54448", "l": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)", "d": []}, {"i": "EC:3.1.1.29", "l": "\"aminoacyl-tRNA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0015928", "l": "fucosidase activity", "d": ["Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981728", "l": "Factor H binds to membrane-associated C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51628", "l": "formate + H(+) + UTP = CO2 + dUTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15658", "l": "1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) => 3-methylcatechol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604368", "l": "Autocatalytic activation of bound proMMP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58458", "l": "(R)-glycerate + D-mannose => (2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030297", "l": "transmembrane receptor protein tyrosine kinase activator activity", "d": ["Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693198", "l": "RHOD binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026502", "l": "NTF3-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58679", "l": "NADPH + O2 + rifamycin SV <=> H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864577", "l": "TFAP2C translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621402", "l": "Defective CP does not oxidise Fe2+ to Fe3+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56523", "l": "Fe-coproporphyrin III + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189062", "l": "lactose + H2O => D-glucose + D-galactose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27355", "l": "H(+) + rebeccamycin + S-adenosyl-L-homocysteine => 4'-demethylrebeccamycin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49919", "l": "(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18007", "l": "D-erythrulose + H(+) + NADPH => D-threitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-377644", "l": "Release of CSK from SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42445", "l": "L-aspartate + NADP(+) => H(+) + iminosuccinate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65539", "l": "1,3,7-trimethylurate + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + theacrine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016688", "l": "L-ascorbate peroxidase activity", "d": ["Catalysis of the reaction: L-ascorbate + hydrogen peroxide = dehydroascorbate + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213239", "l": "Formation of MHC II alpha beta heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694522", "l": "Inner coat assembly and cargo binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005115", "l": "receptor tyrosine kinase-like orphan receptor binding", "d": ["Binding to a receptor tyrosine kinase-like orphan receptor (Ror)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675656", "l": "EDA:EDAR binds EDARADD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43415", "l": "a D-galactosylceramide + H2O <=> an N-acyl-sphingoid base + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75862", "l": "Fall Back to Closed Pre-initiation Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58021", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => eupatolide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15951", "l": "2-oxooctadecanoate + H(+) + NADH => (R)-2-hydroxyoctadecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876262", "l": "EPS15 and HGS bind CBL-monoubiquitinated MET engaged with Listeria InlB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17325", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA", "d": []}, {"i": "EC:2.3.1.117", "l": "\"2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54331", "l": "2 H(+) + hexadecanoyl-[ACP] + 2 NADPH <=> hexadecan-1-ol + holo-[ACP] + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641229", "l": "TLE oligomerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4791278", "l": "APC truncation mutants have impaired AXIN binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70785", "l": "H(+)(in) + L-aspartate(out) + L-glutamate(in) => H(+)(out) + L-aspartate(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53365", "l": "5,6-dihydrouridine(47) in tRNA + NAD(+) => H(+) + NADH + uridine(47) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69831", "l": "campestanol + O2 + reduced [NADPH--hemoprotein reductase] = 6-deoxycathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70645", "l": "D-proline(in) + H(+)(in) => D-proline(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005114", "l": "type II transforming growth factor beta receptor binding", "d": ["Binding to a type II transforming growth factor beta receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56024", "l": "H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649856", "l": "Oxidative damage to the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0071917", "l": "triose-phosphate transmembrane transporter activity", "d": ["Enables the transfer of a triose phosphate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21213", "l": "H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15739", "l": "5-valerolactone + H2O + NADP(+) => cyclopentanone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8963915", "l": "1,25(OH)2D binds VDR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022065", "l": "DSPGs are secreted (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12003", "l": "formate + NADP(+) <=> CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73375", "l": "biotin(out) + 2 Na(+)(out) = biotin(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20696", "l": "2 H(+) + 2 superoxide = H2O2 + O2", "d": []}, {"i": "EC:1.15.1.1", "l": "\"superoxide dismutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54952", "l": "ATP + CoA + nonanoate = AMP + diphosphate + nonanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20764", "l": "(S)-methylmalonyl-CoA + pyruvate = oxaloacetate + propanoyl-CoA", "d": []}, {"i": "EC:2.1.3.1", "l": "\"methylmalonyl-CoA carboxytransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418662", "l": "Src activation following P2Y purinoceptor activation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327733", "l": "FN1 binds Collagen types I-V, VII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2129362", "l": "Fibrillin microfibril assembly (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56443", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.32", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001096", "l": "TFIIF-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase II transcription factor belonging to the TFIIF complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74758", "l": "kaempferide + S-adenosyl-L-methionine <=> 3,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48951", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662608", "l": "MT2A binds cadmium (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35272", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41551", "l": "8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44541", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34110", "l": "glycine + H(+) + hexadecanoyl-CoA <=> 1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855201", "l": "I(1,3,4,6)P4 transports from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29466", "l": "K(+)(in) <=> K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43118", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624951", "l": "TNPO1 binds KIF17 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63707", "l": "mycophenolate + UDP-alpha-D-glucuronate <=> H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47651", "l": "D-ribitol 5-phosphate + H2O <=> phosphate + ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9612501", "l": "SGK phosphorylates CREB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38264", "l": "(2R,3S)-beta-methylmalyl-CoA => 2-methylfumaryl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23439", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O <=> 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052612", "l": "adonirubin 3-hydroxylase activity", "d": ["Catalysis of the reaction: adonirubin + a reduced electron acceptor + oxygen = 3S,3'S-astaxanthin + an oxidized electron acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676229", "l": "WIPIs bind PI3P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66110", "l": "(2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate => 2-oxobutanoate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34061", "l": "didehydroagroclavine + H(+) + NADPH => agroclavine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112430", "l": "Formation of P-TEFb complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983156", "l": "Polyubiquitination of substrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32544", "l": "(2E)-geranyl diphosphate + H2O => 1,8-cineole + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74286", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IIA <=> a 2-acyl-sn-glycero-3-phosphocholine + a lipid IIB", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.240751554780076", "identifiers": [{"i": "GO:0051139", "l": "metal cation:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in)."]}, {"i": "REACT:R-HSA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218815", "l": "p-6Y-VEGFR2 binds NCK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858482", "l": "DVL is recruited to the receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031005", "l": "filamin binding", "d": ["Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046175", "l": "Further sulfation on galactose residues produces KSPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69303", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate <=> benzyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202969", "l": "Caspase mediated cleavage of beta-catenin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029272", "l": "Release of PLCG from FCGR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.233", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022911", "l": "CSPG is secreted (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67845", "l": "a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48280", "l": "ganglioside GM2 + UDP-alpha-D-galactose = ganglioside GM1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25490", "l": "(1S,5S)-alpha-pinene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70778", "l": "6-sulfo-D-quinovose + FMNH2 + O2 <=> 6-dehydro-D-glucose + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419490", "l": "Binding of ATP to P2X receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187293", "l": "SMAD2/3:SMAD4 complex positively regulates JUNB transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112430", "l": "Formation of P-TEFb complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36006", "l": "(S)-4-hydroxy-2-oxohexanoate <=> propanal + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67977", "l": "all-trans-neurosporene => beta-zeacarotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53947", "l": "2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) <=> (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016934", "l": "extracellularly glycine-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane."]}, {"i": "REACT:R-HSA-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65406", "l": "butyl hexanoate + CoA => butan-1-ol + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61219", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47755", "l": "5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine <=> 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45216", "l": "coenzyme M + methyl-Co(III)-[dimethylamine-specific corrinoid protein] = Co(I)-[dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53711", "l": "(2E)-decenoyl-CoA + NADP(+) <=> (2E,4Z)-decadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51473", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444171", "l": "Receptor FFAR2 binds carboxylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0099103", "l": "channel activator activity", "d": ["Direct interaction with a channel (binding or modification), resulting in its opening. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74132", "l": "malvidin + UDP-alpha-D-galactose => H(+) + malvidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40362", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20345", "l": "[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH", "d": []}, {"i": "EC:1.8.1.9", "l": "\"thioredoxin-disulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10956", "l": "(E)-cinnamate + H(+) + NADPH + O2 = H2O + NADP(+) + trans-2-coumarate", "d": []}, {"i": "EC:1.14.13.14", "l": "\"trans-cinnamate 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47732", "l": "cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67202", "l": "acetate + tyramine => H2O + N-acetyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75571", "l": "acetyl-CoA + cyathin A3 = 11-O-acetylcyathin A3 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647746", "l": "EML4 trimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036133", "l": "11-hydroxythromboxane B2 dehydrogenase activity", "d": ["Catalysis of the reaction: thromboxane B2 + NAD+ = 11-dehydro-thromboxane B2 + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202717", "l": "Heterodimerization of CEACAMs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.5", "l": "\"chondroitin AC lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "54.025100461493643", "identifiers": [{"i": "GO:0015079", "l": "potassium ion transmembrane transporter activity", "d": ["Enables the transfer of potassium ions (K+) from one side of a membrane to the other."]}, {"i": "RHEA:29463", "l": "K(+)(in) = K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18498", "l": "L-ribulose 5-phosphate => L-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247960", "l": "Activation of p38 MAPK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621425", "l": "Defective AVP mutants do not bind AVPR1A,B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033800", "l": "isoflavone 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 7-methoxyisoflavone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10212", "l": "2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.48", "l": "\"5-aminovalerate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70531", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29929", "l": "(R)-pantothenate(out) + Na(+)(out) => (R)-pantothenate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26316", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate <=> dihydroxyacetone phosphate + L-aspartate 4-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17944", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate <=> 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32650", "l": "erythromycin C + S-adenosyl-L-methionine <=> erythromycin A + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55647", "l": "ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] <=> ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64691", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39505", "l": "(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+) => (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204364", "l": "ROBO1 binds SLIT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58448", "l": "N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605595", "l": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4332356", "l": "CAMK2 binds MAP3K7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72631", "l": "Formation of the cap-binding eIF4F complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428917", "l": "G13 activation by TP receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17523", "l": "ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate => ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381727", "l": "RAP1A exchanges GDP for GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29667", "l": "H2O(in) = H2O(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186785", "l": "PDGF-AA clevage by Furin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57205", "l": "glyoxal + L-lysyl-[protein] => N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65954", "l": "2 a 1,4-benzosemiquinone + NAD(+) => 2 a quinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67407", "l": "gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63470", "l": "ADP + all-trans-octaprenyl phosphate + H(+) => all-trans-octaprenol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189439", "l": "ALAD condenses 2 dALAs to form PBG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32387", "l": "dihydrocarveol + NAD(+) = dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72024", "l": "nicotinate(in) + urate(out) => nicotinate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36019", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102543", "l": "epsilon-rhodomycinone methylesterase activity", "d": ["Catalysis of the reaction: epsilon-rhodomycinone + H2O <=> 15-demethoxy-epsilon-rhodomycinone + methanol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39584", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34987", "l": "(S)-lactate(in) = (S)-lactate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140761", "l": "sequestered tissue factor -> tissue factor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74426", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404135", "l": "RBP4 binds atROL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48678", "l": "20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13159", "l": "2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH => (R)-glycerate + CO2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69497", "l": "decan-1-ol + O2 => decanal + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54650", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => ent-8alpha-hydroxylabd-13-en-15-yl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25181", "l": "acetyl-CoA + putrescine = CoA + H(+) + N-acetylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15140", "l": "galactitol 1-phosphate + NAD(+) <=> H(+) + keto-L-tagatose 6-phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102451", "l": "kaempferide 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: kaempferide + S-adenosyl-L-methionine <=> 3,4'-dimethylkaempferol + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034837", "l": "2-mercaptobenzothiazole-cis-6,7-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: 2-mercaptobenzothiazole-cis-6,7-dihydrodiol = 6,7-dihydroxy-2-mercaptobenzothiazole + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016149", "l": "translation release factor activity, codon specific", "d": ["A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662708", "l": "CREB binds IL6 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61921", "l": "(2R,4S)-ketoconazole(in) + ATP + H2O => (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39501", "l": "(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O => (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.4", "l": "\"exodeoxyribonuclease (phage SP3-induced)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.712091546727706", "identifiers": [{"i": "GO:0016878", "l": "acid-thiol ligase activity", "d": ["Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54369", "l": "acetaldehyde + H(+) + pyruvate => acetoin + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786155", "l": "POLN binds ICL-DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615910", "l": "SUMOylation of PCNA with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39203", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADPH = NADP(+) + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55012", "l": "(1S,4R)-1-hydroxylimonen-2-one + NADPH + O2 = (3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5333671", "l": "CLCAs self cleave (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043334", "l": "2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-205244", "l": "Recruitment of CBL to KIT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43559", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48301", "l": "H2O + prostaglandin F2alpha 1-glyceryl ester => glycerol + H(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56715", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] <=> H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390673", "l": "CHRM2,4 bind acetylcholine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37249", "l": "phosphate + thymidine => H2O + thymidine 3'-monophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0060072", "l": "large conductance calcium-activated potassium channel activity", "d": ["Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102443", "l": "L-2-hydroxycarboxylate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: NAD(1-) + a (2S)-2-hydroxycarboxylate <=> NADH(2-) + H+ + a 2-oxo carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0031544", "l": "peptidyl-proline 3-dioxygenase activity", "d": ["Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205649", "l": "p62 links damaged mitochondria to LC3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39776", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196017", "l": "Dynamin is recruited to the gap junction plaque (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691150", "l": "TFR2 dimer binds 2xholoTF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25492", "l": "(2E)-geranyl diphosphate = (-)-beta-phellandrene + diphosphate", "d": []}, {"i": "EC:4.2.3.52", "l": "\"(4S)-beta-phellandrene synthase (geranyl-diphosphate-cyclizing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18670", "l": "adenosine + H2O => adenine + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33712", "l": "4-sulfomuconolactone + H2O => 2 H(+) + maleylacetate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034803", "l": "3-hydroxy-2-naphthoate 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-naphthoate + O2 = (3E)-3-[(6Z)-6-(carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375151", "l": "Interaction of NCAM1 with collagens (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62996", "l": "(8Z,11Z,14Z)-eicosatrienamide + H2O = (8Z,11Z,14Z)-eicosatrienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23976", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate", "d": []}, {"i": "EC:6.5.1.4", "l": "\"RNA 3'-terminal-phosphate cyclase (ATP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22716", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.25", "l": "\"cholesterol 24-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48911", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5626938", "l": "Beta-catenin binds SOX proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15852", "l": "2 Fe(III)-[cytochrome c] + L-ascorbate <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42066", "l": "2',3'-cGAMP + 2 diphosphate => ATP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32142", "l": "ATP + CoA + malonate <=> AMP + diphosphate + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19179", "l": "(3S)-3,6-diaminohexanoate => L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209903", "l": "Noradrenaline is converted to adrenaline (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10653", "l": "a long-chain fatty aldehyde + H2O + NAD(+) => a long-chain fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62638", "l": "(R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O => (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855375", "l": "PTPN22 dissociates from CSK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25631", "l": "H(+) + laricitrin + S-adenosyl-L-homocysteine => myricetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75275", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate = (10R,11R)-epoxy-(9S)-hydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48221", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA => (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177934", "l": "EGFR autophosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404134", "l": "RBP4:atROL binds TTR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198599", "l": "AKT phosphorylates MDM2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65276", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18804", "l": "(cis-prenyl)n-diphosphate + isopentenyl diphosphate <=> (cis-prenyl)(n+1)-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58737", "l": "H2O + TTP => 5-methyl-UMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54139", "l": "cytidine(48) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31550", "l": "2 (2E,6E)-farnesyl diphosphate <=> 15-cis-4,4'-diapophytoene + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24245", "l": "NADP(+) + pseudotropine => H(+) + NADPH + tropinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14234", "l": "a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57382", "l": "(13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983061", "l": "TSLP binds CRLF2:IL7R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008737", "l": "L-fuculokinase activity", "d": ["Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56867", "l": "12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH <=> (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40425", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395517", "l": "NADPH transfers electrons to FDXR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27897", "l": "3'-CMP + H2O <=> cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58155", "l": "H2O + NAD(+) + phosphonoacetaldehyde <=> 2 H(+) + NADH + phosphonoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69340", "l": "(E)-prop-1-en-1-SO-peroxol = (Z)-propanethial S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858252", "l": "HDLBP binds HDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9028730", "l": "Activated NTRK2 binds FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197698", "l": "Src phosphorylate WASP,N-WASP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62687", "l": "norrubrofusarin + S-adenosyl-L-methionine <=> H(+) + rubrofusarin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60917", "l": "a cytidine in mRNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012835", "l": "GDIs block activation of RHOA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60637", "l": "N-(dodecanoyl)-sphing-4-enine-1-phosphocholine => choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48177", "l": "decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373745", "l": "SDK1 homophillic interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0050499", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a NAD(P)+ to NAD(P)H."]}, {"i": "EC:1.20.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950362", "l": "EBI3:CANX binds IL12A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445704", "l": "Calcium Binds Caldesmon (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28308", "l": "beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24828", "l": "dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25195", "l": "3-methylcatechol + H(+) + NADH => (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40825", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429157", "l": "ABCC4 accumulation of dense granule contents (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-984733", "l": "Kinesin-3 is a dimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75567", "l": "acetyl-CoA + cyathatriol = 11-O-acetylcyathatriol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55078", "l": "3-methylsulfanylpropanal + CO2 => 4-methylsulfanyl-2-oxobutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622415", "l": "RIP2 binds NEMO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018495", "l": "2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-hydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 2-ketocyclohexane-1-carboxyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58243", "l": "H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] <=> ADP-D-ribose + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445084", "l": "Phosphorylation of L1 by SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928641", "l": "PAK binds RAC and bPIX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9005980", "l": "IL21 binds IL21R:JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299359", "l": "Activation of TALK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22824", "l": "2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34819", "l": "dihydrocurcumin + NADP(+) = curcumin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33898", "l": "NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose <=> H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983152", "l": "Transfer of ubiquitin from E1 to E2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59297", "l": "an N-acylglycine + 2 L-ascorbate + O2 => an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49543", "l": "(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate <=> (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71413", "l": "3,3',5-triiodo-L-thyronine(in) + L-tryptophan(out) => 3,3',5-triiodo-L-thyronine(out) + L-tryptophan(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37492", "l": "4-coumaroyl-CoA + S-adenosyl-L-methionine => CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52351", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate <=> (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102537", "l": "ecdysone-phosphate phosphatase activity", "d": ["Catalysis of the reaction: ecdysone 22-phosphate + H2O <=> ecdysone + hydrogenphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798374", "l": "DYRK2 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265166", "l": "Exocytosis of Insulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52791", "l": "chlorophyll a + 2 H(+) <=> Mg(2+) + pheophytin a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63337", "l": "alpha-D-xylose => beta-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37456", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46623", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol <=> (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111966", "l": "GRK2 binds CALM1:4Ca2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380930", "l": "Phosphorylated AMPK binds AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149519", "l": "MMACHC decyanates CNCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014456", "l": "GDIs block activation of RHOG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016316", "l": "phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034283", "l": "syn-stemod-13(17)-ene synthase activity", "d": ["Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemod-13(17)-ene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54324", "l": "a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin] = a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810643", "l": "EPPIN protein complex binds bacteria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376419", "l": "Formation of NR-MED1 Coactivator Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161282", "l": "Elastic fibres bind associated proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5138432", "l": "DVL2 is phosphorylated by PKC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69506", "l": "H2O2 + N-acetyl-D-glucosamino-1,5-lactone => N-acetyl-D-glucosamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62594", "l": "(6E)-8-oxogeranial + H(+) + NADPH => (S)-8-oxocitronellyl enol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166792", "l": "Conversion of C2 into C2a and C2b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380949", "l": "AMPK is dephosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5432825", "l": "HMGB1 binds TLR4:LY96 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45722", "l": "N-hexadecanoylsphing-4-enine(out) => N-hexadecanoylsphing-4-enine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32190", "l": "cholest-5-en-3-one <=> cholest-4-en-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0098599", "l": "palmitoyl hydrolase activity", "d": ["Catalysis of a hydrolase reaction that removes a palmitoyl moiety from some substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8931981", "l": "RUNX1 binds ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66105", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.47", "l": "\"N-acylsphingosine galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43336", "l": "H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) = CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out)", "d": []}, {"i": "EC:7.2.4.1", "l": "\"carboxybiotin decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854222", "l": "TBC1D3 associates with RAB5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102387", "l": "2-phenylethanol acetyltransferase activity", "d": ["Catalysis of the reaction: 2-phenylethanol + acetyl-CoA = phenethyl acetate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29493", "l": "cis-muurola-4(14),5-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798372", "l": "ATM phosphorylates DYRK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60273", "l": "N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.958976004066542", "identifiers": [{"i": "GO:0016885", "l": "ligase activity, forming carbon-carbon bonds", "d": ["Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}, {"i": "EC:6.4.-.-", "l": "\"Forming carbon-carbon bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58060", "l": "2-sulfinoacetaldehyde + H2O = acetaldehyde + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62671", "l": "deoxyherqueinone + H(+) + NADPH + O2 <=> H2O + herqueinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014449", "l": "RHOG binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14272", "l": "2 a quinone + H(+) + NADPH <=> 2 a 1,4-benzosemiquinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111915", "l": "CAMK4 autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762345", "l": "PREDN:ALB dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58190", "l": "dihydroisopentenyldehydrorhodopin + diphosphate => all-trans-lycopene + dimethylallyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29609", "l": "H(+) + NADH + 2 nitric oxide => H2O + NAD(+) + nitrous oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35345", "l": "3-oxodocosanoyl-CoA + H(+) + NADPH => 3-hydroxydocosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14528", "l": "A + beta-cyclopiazonate <=> AH2 + alpha-cyclopiazonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5665871", "l": "ADRM1 binds 26S proteasome (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14064", "l": "H2O + N-(carboxymethyl)-D-alanine + NAD(+) <=> glycine + H(+) + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13658", "l": "acetyl-[citrate lyase ACP] + H2O => acetate + H(+) + holo-[citrate lyase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72274", "l": "formate(out) + oxalate(in) <=> formate(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873923", "l": "STARD10 binds LPCAT1 and PC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030586", "l": "[methionine synthase] reductase activity", "d": ["Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710353", "l": "GSDMD (1-275) binds cardiolipin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71939", "l": "2-oxoglutarate(out) + 3 Na(+)(out) = 2-oxoglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70856", "l": "L-glutamine(out) + L-serine(in) + Na(+)(out) => L-glutamine(in) + L-serine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638209", "l": "Defective SLC2A9 does not transport Fru, Glc, urate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74371", "l": "a carboxylate(out) + nicotinate(in) = a carboxylate(in) + nicotinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48869", "l": "H2O + NADH => AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32765", "l": "(3R)-3-methyl-D-ornithyl-N(6)-L-lysine + ADP + H(+) + phosphate => (3R)-3-methyl-D-ornithine + ATP + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47685", "l": "[(1->2)-beta-D-glucosyl](n) + phosphate => [(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757686", "l": "SERPINA6 binds PREDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873794", "l": "PCTP binds PC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0000150", "l": "DNA strand exchange activity", "d": ["Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA."]}, {"i": "REACT:R-HSA-912458", "l": "Formation of meiotic heteroduplex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56360", "l": "13-deoxycarminomycin + H(+) + NADPH + O2 = 13-dihydrocarminomycin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693347", "l": "HTR1A binds 5HT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48494", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418849", "l": "DAPK binds UNC5B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015438", "l": "ABC-type teichoic acid transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399939", "l": "Autophosphorylation of PAK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26003", "l": "D-arabinitol 1-phosphate + NAD(+) => D-xylulose 5-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102322", "l": "2-propylphenol monooxygenase activity", "d": ["Catalysis of the reaction: 2-propylphenol + O2 + NADH + H+ = 3-propylcatechol + H2O + NAD."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59669", "l": "D-cellohexaose + O2 => D-cellohexaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23547", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49937", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63226", "l": "2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69809", "l": "AMP + benzoyl-CoA + H(+) => benzoyl-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036134", "l": "12-hydroxyheptadecatrienoic acid synthase activity", "d": ["Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36355", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.114", "l": "\"tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50734", "l": "(S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69741", "l": "3-phenylsuccinyl-CoA + succinate => phenylsuccinate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000120", "l": "CBLIF binds RCbl (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56431", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31768", "l": "2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine => L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43675", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55024", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635868", "l": "ub-GLI is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950752", "l": "IL12A:IL12B translocates from Golgi lumen to late endosome lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912790", "l": "CBL binds CRK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044378", "l": "non-sequence-specific DNA binding, bending", "d": ["The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.166", "l": "\"4-nitrocatechol 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11435", "l": "S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside <=> 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74952", "l": "(3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + 2-oxoglutarate + O2 => (3R)-3-isocyanylbutanoate + 2 CO2 + 2 H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944229", "l": "Association of procollagen type IX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65138", "l": "1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964773", "l": "OXGR1 binds 2OG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389381", "l": "Gads binds CD28 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31005", "l": "germanicol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27530", "l": "(2E,6E)-farnesyl diphosphate + H2O = (3S,6E)-nerolidol + diphosphate", "d": []}, {"i": "EC:4.2.3.48", "l": "\"(3S,6E)-nerolidol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65660", "l": "A + calciol + H2O = AH2 + calcidiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25109", "l": "ATP + pyridoxine => ADP + H(+) + pyridoxine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156682", "l": "PLK1 phosphorylates NUDC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67757", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37090", "l": "[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine <=> 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76052", "l": "Binding of TFIIIA To type 1 Promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32511", "l": "(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O = (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14784", "l": "ATP + CoA + heptanedioate <=> 6-carboxyhexanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176298", "l": "Activation of claspin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875523", "l": "MET binds TNS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10788", "l": "2-dehydro-D-gluconate + ATP = 6-phospho-2-dehydro-D-gluconate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.13", "l": "\"dehydrogluconokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43060", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate = beta-D-glucose 1-phosphate + glycerol", "d": []}, {"i": "EC:2.4.1.332", "l": "\"1,2-alpha-glucosylglycerol phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51760", "l": "a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682967", "l": "WHSC1 binds DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.054311793581761", "identifiers": [{"i": "GO:0004619", "l": "phosphoglycerate mutase activity", "d": ["Catalysis of the reaction: 2-phosphoglycerate = 3-phosphoglycerate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14682", "l": "2 2-aminophenol + A + O2 => 2-aminophenoxazin-3-one + AH2 + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050038", "l": "L-xylulose reductase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + xylitol = L-xylulose + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-398184", "l": "LARG activation by G alpha 12/13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687107", "l": "MAPK4,6 translocate to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30543", "l": "(S)-carnitine + ATP + CoA = (S)-carnitinyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0010297", "l": "heteropolysaccharide binding", "d": ["Binding to a heteropolysaccharide, a glycan composed of more than one type of monosaccharide residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77609", "l": "Binding of APOBEC-1 to form editosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799332", "l": "ATR phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10796", "l": "albendazole + H(+) + NADPH + O2 = albendazole S-oxide + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.32", "l": "\"albendazole monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213246", "l": "Disassociation of CLIP from MHC II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0000179", "l": "rRNA (adenine-N6,N6-)-dimethyltransferase activity", "d": ["Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693536", "l": "ATM phosphorylates MDC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38033", "l": "(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2 => (3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004859", "l": "phospholipase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19822", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36841", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33593", "l": "CoA + H(+) + N-tetracosanoylsphinganine => sphinganine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52737", "l": "(Z)-indolylmethyl desulfoglucosinolate + 3'-phosphoadenylyl sulfate => (Z)-glucobrassicin + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41437", "l": "(9Z)-octadecenoyl-CoA + cholesterol => cholesteryl (9Z-octadecenoate) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63691", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24897", "l": "5-hydroxyxanthotoxin + S-adenosyl-L-methionine <=> isopimpinellin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66258", "l": "diphosphate + IC-asc-C7-AMP => ATP + H(+) + IC-asc-C7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32643", "l": "2 Fe(III)-[cytochrome c] + H2O + lupanine = 17-hydroxylupanine + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}, {"i": "EC:1.17.2.2", "l": "\"lupanine 17-hydroxylase (cytochrome c)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621054", "l": "REST binds the VGF promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63158", "l": "docosanoate + taurine => H2O + N-docosanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69744", "l": "(S)-2-benzylsuccinate + succinyl-CoA => (S)-2-benzylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825631", "l": "MESP2 binds the RIPPLY2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371591", "l": "Trimerization of cytosolic HSF1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41557", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2 => (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64420", "l": "H(+)(out) + L-alanyl-L-proline(out) = H(+)(in) + L-alanyl-L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5228992", "l": "ROCK1,ROCK2 are activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52496", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14087", "l": "5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate => (2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40600", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047420", "l": "N-acyl-D-amino-acid deacylase activity", "d": ["Catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708866", "l": "pro-F2R binds vorapaxar (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9818682", "l": "MEN1 binds MLL2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473594", "l": "Collagen type II degradation by MMP15 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67791", "l": "2 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a cardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19386", "l": "UDP-alpha-D-glucose + vomilenine => H(+) + raucaffricine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71823", "l": "3,3'-diiodo-L-thyronine(out) = 3,3'-diiodo-L-thyronine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12014", "l": "ADP + H(+) + thiamine phosphate => ATP + thiamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37847", "l": "13-dihydrodaunorubicin + H(+) + NADPH + O2 = daunorubicin + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66187", "l": "3',5'-cyclic AMP(in) + ATP + H2O <=> 3',5'-cyclic AMP(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33643", "l": "(9Z)-tetradecenoate + ATP + CoA = (9Z)-tetradecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733216", "l": "COL1A2 gene expression is stimulated by p-2S-SMAD3:p-2S-SMAD3:SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73993", "l": "beta-araneosene + diphosphate => geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52717", "l": "a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH => a long-chain primary fatty alcohol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000310", "l": "AURKA phosphorylates PLK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73055", "l": "estrone 3-sulfate(out) + hydrogencarbonate(in) = estrone 3-sulfate(in) + hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54762", "l": "5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate => ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30951", "l": "(2E,6E)-farnesyl diphosphate + H2O = alpha-eudesmol + diphosphate", "d": []}, {"i": "EC:4.2.3.85", "l": "\"alpha-eudesmol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37140", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate => 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71134", "l": "H(+)(in) + L-asparagine(out) + Na(+)(out) <=> H(+)(out) + L-asparagine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9701064", "l": "TRPV1 binds TRPV1 agonists (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66048", "l": "2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27629", "l": "D-erythrose 4-phosphate + D-xylulose 5-phosphate <=> beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806413", "l": "TP53 binds the MLH1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48568", "l": "3-chlorocatechol + O2 = (2E,4Z)-2-chloromuconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047106", "l": "4-hydroxyphenylacetaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + (4-hydroxyphenyl)acetaldehyde + H2O = NADH + 4-hydroxyphenylacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913451", "l": "IL3RB is phosphorylated on Ser-585 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004810", "l": "CCA tRNA nucleotidyltransferase activity", "d": ["Catalysis of the reaction: a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047086", "l": "ketosteroid monooxygenase activity", "d": ["Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706364", "l": "Internalization of ubiquitinated FLT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426032", "l": "DAG is metabolized by DAGL to 2-AG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641206", "l": "RSPOs bind LGRs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614665", "l": "SQR oxidizes sulfide to bound persulfide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0016815", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN."]}, {"i": "EC:3.5.5.-", "l": "\"In nitriles\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20081", "l": "H2O + N-methylhexanamide = hexanoate + methylamine", "d": []}, {"i": "EC:3.5.1.39", "l": "\"alkylamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71007", "l": "L-phenylalanine(out) + L-tryptophan(in) = L-phenylalanine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55412", "l": "[phosphate](n) + GTP = [phosphate](n+1) + GDP", "d": []}, {"i": "EC:2.7.4.34", "l": "\"GDP-polyphosphate phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17945", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.51", "l": "\"(S)-limonene 6-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863727", "l": "STON2 is neddylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36891", "l": "(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 = (9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428273", "l": "SPHK1 phosphorylates SPG to S1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63447", "l": "(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin <=> GMP + H(+) + oxidized coenzyme F420-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2317314", "l": "AKT binds PDPK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753634", "l": "GGT dimers hydrolyse APAP-SG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195275", "l": "Phosphorylation of APC component of the destruction complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10059", "l": "(3S)-3-aminobutanoyl-CoA <=> (2E)-butenoyl-CoA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467775", "l": "Autocleavage of ESPL1 (Separase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49321", "l": "all-trans-violaxanthin => (5R,6S)-5,6-epoxi-capsanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61902", "l": "A + betaenone B => AH2 + betaenone C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25610", "l": "beta-D-allofuranose => beta-D-allopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73072", "l": "apigenin + S-adenosyl-L-methionine => genkwanin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58184", "l": "H(+) + NADPH + 2 phytyl diphosphate = (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11895", "l": "6-O-methylnorlaudanosoline + S-adenosyl-L-methionine <=> H(+) + nororientaline + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10270", "l": "2-hydroxy-3-oxopropanoate + pyruvate => 2-dehydro-3-deoxy-D-glucarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709098", "l": "DHFR dimer reduces FOLA to DHF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664918", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-912790", "l": "CBL binds CRK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26315", "l": "dihydroxyacetone phosphate + L-aspartate 4-semialdehyde => 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20334", "l": "ATP + L-seryl-[acetyl-CoA carboxylase] => ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56344", "l": "a 7-hydroxyisoflavone + UDP-alpha-D-glucose = a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391372", "l": "GNRHR binds GNRH1,2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12190", "l": "(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2 => (R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0097199", "l": "cysteine-type endopeptidase activity involved in apoptotic signaling pathway", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65418", "l": "dGMP(out) + NAD(+)(in) => dGMP(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55433", "l": "11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58607", "l": "FAD + 2 H(+) + NADH + O2 <=> FADH2-C4alpha-hydroperoxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57504", "l": "3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72527", "l": "1-hydroxy-6-methoxyphenazine + S-adenosyl-L-methionine = 1,6-dimethoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944227", "l": "Association of procollagen type XXII (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66484", "l": "16alpha-hydroxygypsogenate + UDP-alpha-D-glucose = 16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65516", "l": "5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O = NH4(+) + pre-mycofactocin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56534", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72480", "l": "citrate(out) + trans-aconitate(in) => citrate(in) + trans-aconitate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400204", "l": "PPARA binds RXRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113705", "l": "RNA Polymerase III Productive Transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43496", "l": "L-gulonate + NAD(+) = H(+) + keto-D-fructuronate + NADH", "d": []}, {"i": "EC:1.1.1.380", "l": "\"L-gulonate 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2201341", "l": "Endocytosis of TRAM (TICAM2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427570", "l": "Group 3 - Selective Cl- transport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45974", "l": "9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+) => 3-oxochol-4-en-22-oate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70680", "l": "glycine betaine(in) + H(+)(in) => glycine betaine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21783", "l": "A + cyclohexanone <=> AH2 + cyclohex-2-enone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16598", "l": "ATP + NH4(+) + UTP => ADP + CTP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373717", "l": "DCC interacts with DIP13alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381608", "l": "cAMP activates EPAC2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299297", "l": "Activation of THIK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067646", "l": "JAK1,JAK2,(TYK2) bind IL6ST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50263", "l": "11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione <=> (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36888", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849102", "l": "SRMS phosphorylates PTK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16532", "l": "ADP + H(+) + sulfate <=> adenosine 5'-phosphosulfate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428749", "l": "Activated TP receptor binds G-proten Gq (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49369", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) => 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1370500", "l": "PRLR binds SCF beta-TrCP complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30018", "l": "alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose <=> alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67595", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O <=> (R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111883", "l": "Hydrolysis of phosphatidylcholine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697086", "l": "Rifampicin binds Mtb RNAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25955", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde <=> 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59872", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37815", "l": "(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 = 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44447", "l": "a 1,2-diacylglycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810643", "l": "EPPIN protein complex binds bacteria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391933", "l": "EP3 receptor can bind PGE2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018670", "l": "4-aminobenzoate 1-monooxygenase activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + NADPH + H+ + O2 = 4-hydroxyaniline + NADP+ + H2O + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017447", "l": "MECP2 binds PPARG gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203553", "l": "eNOS binds NOSIP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69750", "l": "(indol-3-yl)acetate + succinyl-CoA <=> (indol-3-yl)acetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30137", "l": "CoA + dodecanoate + H(+) => dodecanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61434", "l": "(6E)-8-oxogeranial + H(+) + NADPH => (R)-8-oxocitronellyl enol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69096", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine = H2O + kynurenate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635859", "l": "GLI:SUFU dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36204", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66903", "l": "acetyl-CoA + L-tryptophan + malonyl-CoA <=> CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483174", "l": "PE is methylated to PC by PEMT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015572", "l": "N-acetylglucosamine transmembrane transporter activity", "d": ["Enables the transfer of N-acetylglucosamine from one side of a membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9032798", "l": "DOCK3 activates RAC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76031", "l": "2 H2O2 => O2 + 2 H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043829", "l": "tRNA-specific adenosine-37 deaminase activity", "d": ["Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52677", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O => [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033926", "l": "glycopeptide alpha-N-acetylgalactosaminidase activity", "d": ["Catalysis of the reaction: D-galactosyl-3-(N-acetyl-alpha-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-alpha-D-galactosamine + L-serine in mucin-type glycoproteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47321", "l": "(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate => 3-oxo-3-phenylpropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68754", "l": "alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein] => alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37757", "l": "1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72009", "l": "succinate(out) + urate(in) => succinate(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39428", "l": "(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH => (23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727607", "l": "MME:Zn2+ binds sacubitrilat (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70001", "l": "L-threonine(out) + Na(+)(out) => L-threonine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24754", "l": "3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655247", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 point and translocation mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250930", "l": "B-WICH recruits histone acetyltransferases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602484", "l": "Activation of proMMP11 by FURIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419153", "l": "5-phosphoribosylamine + glycine + ATP <=> 5-phosphoribosylglycinamide (GAR) + adenosine 5'-diphosphate + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63533", "l": "angiotensin I + H2O => angiotensin-(1-9) + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65170", "l": "A + H2O + preaustinoid A1 => AH2 + O2 + preaustinoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.2", "l": "\"exoribonuclease H\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66193", "l": "ATP + bilirubin-bisglucuronoside(in) + H2O => ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015505", "l": "uracil:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uracil(out) + cation(out) = uracil(in) + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14787", "l": "diphosphate + RNA(n)-3'-uridine ribonucleotide => RNA(n) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3858482", "l": "DVL is recruited to the receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9818682", "l": "MEN1 binds MLL2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19193", "l": "A + all-trans-13,14-dihydroretinol = AH2 + all-trans-retinol", "d": []}, {"i": "EC:1.3.99.23", "l": "\"all-trans-retinol 13,14-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002401", "l": "Association of procollagen type XVIII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0017147", "l": "Wnt-protein binding", "d": ["Binding to a Wnt-protein, a secreted growth factor involved in signaling."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26481", "l": "1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) <=> a 2-demethylmenaquinol + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.35", "l": "\"2-dehydrotetronate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37641", "l": "1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38098", "l": "gamma-tocotrienol + S-adenosyl-L-methionine <=> alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14516", "l": "ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine <=> ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16395", "l": "H(+) + juvenile hormone II carboxylate + methanol => H2O + juvenile hormone II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-874087", "l": "SGT1 binds HSP90 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043996", "l": "histone H4K8 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034850", "l": "isooctane monooxygenase activity", "d": ["Catalysis of the reaction: isooctane + 1/2 O2 = 2,4,4-trimethyl-1-pentanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864595", "l": "TFAP2B homodimer binds YEATS4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25108", "l": "ATP + pyridoxine = ADP + H(+) + pyridoxine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.37", "l": "\"2',3'-cyclic-nucleotide 3'-phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60722", "l": "(E)-hept-2-enoate + 2 H(+) + NADPH => (E)-hept-2-enal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20198", "l": "[heparosan-N-sulfate](n) => [heparan-N-sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.99", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51993", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60739", "l": "(2E,6E)-farnesal + H2O + NADP(+) <=> (2E,6E)-farnesoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66925", "l": "[(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA => [(R)-3-hydroxyalkanoate](n+1) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062124", "l": "4-hydroxybutyrate receptor activity", "d": ["Combining with 4-hydroxybutyrte to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863463", "l": "STON2 binds SYT proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27508", "l": "benzoate + ecgonine methyl ester + H(+) => cocaine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14029", "l": "A + H2O + selenite = AH2 + selenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28961", "l": "D-xylose(out) + H(+)(out) => D-xylose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0005436", "l": "sodium:phosphate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38523", "l": "1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67361", "l": "H2O + L-threonyl-L-threonine => 2 L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12251", "l": "NADP(+) + UDP-N-acetyl-alpha-D-muramate <=> H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214871", "l": "Phosphorylated CACT is degraded in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58961", "l": "benzaldehyde + H2O + O2 => benzoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606602", "l": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675198", "l": "Activated MAPKs phosphorylate BRAF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004385", "l": "guanylate kinase activity", "d": ["Catalysis of the reaction: ATP + GMP = ADP + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67888", "l": "3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine = 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61850", "l": "cholesteryl 3-beta-D-glucoside + H(+) + UDP => cholesterol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40102", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51519", "l": "(R)-reticuline + S-adenosyl-L-methionine <=> (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209165", "l": "ID1 sequesters ETS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8960973", "l": "RLBP1:11cRAL dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11671", "l": "[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O <=> [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68694", "l": "3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(beta-D-glucuronate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693609", "l": "ATM phosphorylates TP53 at S15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156678", "l": "Activation of Cdc25C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58011", "l": "(20S)-ginsenoside F1 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rg1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665515", "l": "P2RX4,7 binds itself to form trimeric non-selective cation channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754129", "l": "CDK6 inhibitors bind CDK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46139", "l": "aminopyrrolnitrin + H(+) + NADPH + 2 O2 <=> 2 H2O + NADP(+) + pyrrolnitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20025", "l": "gibberellin A3 + UDP-alpha-D-glucose = gibberellin A3 O-beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.176", "l": "\"gibberellin beta-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626914", "l": "α2-agonists bind ADRA2A,B,C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14398", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) => (4Z)-2-oxohept-4-enedioate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202489", "l": "Oligomerization of Bcl10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627078", "l": "XIAP binds CASP9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53877", "l": "a cytidine in tRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3858482", "l": "DVL is recruited to the receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60212", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59026", "l": "dihexadecanoylglycerol + H(+) + hexadecanoate => H2O + trihexadecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20580", "l": "3-hydroxyaminophenol <=> aminohydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388831", "l": "Phosphorylation of CD28 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675947", "l": "TNFSF18 binds TNFRSF18 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26237", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (2E,6E,10E)-geranylgeraniol + diphosphate", "d": []}, {"i": "EC:3.1.7.5", "l": "\"geranylgeranyl diphosphate diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32909", "l": "2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61912", "l": "ATP + H2O + voriconazole(in) = ADP + H(+) + phosphate + voriconazole(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37644", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47580", "l": "ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GT2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38710", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32502", "l": "(1R,5R)-sabinene + H(+) + NADPH + O2 <=> (1S,3R,5S)-sabinol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44667", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23316", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 = 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil", "d": []}, {"i": "EC:1.14.11.10", "l": "\"pyrimidine-deoxynucleoside 1'-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000112", "l": "CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67865", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] => 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5333671", "l": "CLCAs self cleave (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29899", "l": "ATP + D-xylose(out) + H2O = ADP + D-xylose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23866", "l": "2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP => 4-CDP-2-C-methyl-D-erythritol 2-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67739", "l": "N-acetyl-alpha-neuraminate <=> aceneuramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15287", "l": "diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate => AMP + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20404", "l": "a beta-lactam + H2O <=> a substituted beta-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111930", "l": "Adenylate cyclase produces cAMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75277", "l": "(10R,11R)-epoxy-(9S)-hydroxy-(12Z)-octadecenoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168923", "l": "Collagen type XVIII endostatin release (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60892", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O = a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033568", "l": "lactoferrin receptor activity", "d": ["Combining with lactoferrin and delivering lactoferrin into the cell via endocytosis. Lactoferrin is an iron-binding glycoprotein which binds ferric iron most efficiently at low pH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64265", "l": "atrochrysone carboxylate + H(+) => atrochrysone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33953", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP => ribostamycin + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59527", "l": "9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] <=> 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49892", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 = (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60247", "l": "2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] <=> 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55711", "l": "[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) <=> [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0003896", "l": "DNA primase activity", "d": ["Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases."]}, {"i": "EC:2.7.7.101", "l": "\"DNA primase DnaG\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373732", "l": "Nephrin trans-homophilic interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849906", "l": "SALM1 binds NMDA receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102945", "l": "soyasapogenol B UDP-glucosyl transferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose(2-) + soyasapogenol B <=> UDP(3-) + a soyasapogenol B monoglucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48268", "l": "4',4'-dihydroxyechinenone = canthaxanthin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24184", "l": "4,5-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO2", "d": []}, {"i": "EC:4.1.1.55", "l": "\"4,5-dihydroxyphthalate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73985", "l": "(-)-beta-barbatene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51040", "l": "indole-3-pyruvate imine dimer = chromopyrrolate + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22922", "l": "1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate => L-glutamine + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008768", "l": "UDP-sugar diphosphatase activity", "d": ["Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190258", "l": "FGFR2c binds to FGF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11940", "l": "2 H(+) + H2O + L-citrulline = CO2 + L-ornithine + NH4(+)", "d": []}, {"i": "EC:3.5.1.20", "l": "\"citrullinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099102", "l": "G-protein gated potassium channel activity involved in regulation of postsynaptic membrane potential", "d": ["Any G-protein gated potassium channel activity that is involved regulation of postsynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0034190", "l": "apolipoprotein receptor binding", "d": ["Binding to an apolipoprotein receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70801", "l": "L-lysine(out) + L-ornithine(in) => L-lysine(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102858", "l": "1-18:2-2-18:3-phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:3-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174058", "l": "Degradation of multiubiquitinated Cdh1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706287", "l": "Active FLT3 binds to ABL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902388", "l": "ceramide 1-phosphate transfer activity", "d": ["Removes a ceramide 1-phosphate from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}, {"i": "REACT:R-HSA-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63899", "l": "aspulvinone E + hnu <=> isoaspulvinone E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634916", "l": "CDK5 gene expression is stimulated by NPAS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362465", "l": "GHBP binds GHR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53023", "l": "a plastoquinone + an L-alpha-amino acid + H2O <=> a 2-oxocarboxylate + a plastoquinol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264848", "l": "apoA-I binds to CUBN:AMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62272", "l": "4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57440", "l": "2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] = 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617194", "l": "Phospho-STAT3 binds the promoter of the CEBPB gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64499", "l": "3,5,7,9,11-pentaoxododecanoyl-[ACP] <=> 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12861", "l": "guanosine + H(+) + H2O = NH4(+) + xanthosine", "d": []}, {"i": "EC:3.5.4.15", "l": "\"guanosine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427570", "l": "Group 3 - Selective Cl- transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52797", "l": "2 H(+) + Ni-sirohydrochlorin => Ni(2+) + sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43467", "l": "H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443779", "l": "Linkage of L1 with treadmilling F-actin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30440", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) => 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912385", "l": "Phosphorylated NICD1 binds FBXW7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690494", "l": "RHOB translocates to the endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.43", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950567", "l": "Expression of Plasminogen activator inhibitor 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11148", "l": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O", "d": []}, {"i": "EC:1.16.3.1", "l": "\"ferroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381668", "l": "cAMP activates EPAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-844447", "l": "NLRP1 senses MDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53943", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 <=> 18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51858", "l": "(2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73593", "l": "CTP(in) + dUTP(out) => CTP(out) + dUTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953037", "l": "E2F8 forms homodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73659", "l": "ADP(out) + ATP(in) + H(+)(out) + Mg(2+)(in) = ADP(in) + ATP(out) + H(+)(in) + Mg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73932", "l": "Resynthesis of excised residue by POLB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72922", "l": "4-O-demethylbarbatate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42732", "l": "guanosine(527) in 16S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.170", "l": "\"16S rRNA (guanine(527)-N(7))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "38.53158194392558", "identifiers": [{"i": "GO:0003824", "l": "catalytic activity", "d": ["Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809680", "l": "MTMR12 binds MTM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64581", "l": "(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate => diphosphate + nerylneryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73484", "l": "D-lysine(in) + L-ornithine(out) => D-lysine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641229", "l": "TLE oligomerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38521", "l": "(9Z)-octadecenoate + 2-octadecanoylglycerol + H(+) => 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389976", "l": "Beta-tubulin:GTP:Cofactor D+alpha-tubulin:GTP:Cofactor E-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2995334", "l": "COX15 transforms heme O to heme A (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21055", "l": "(S)-2-hydroxypropyl-coenzyme M + NAD(+) <=> 2-oxopropyl-coenzyme M + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850831", "l": "KLK5 cleaves and activates KLK8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850797", "l": "SPINK6 binds KLK13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877153", "l": "STARD7 binds PC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25561", "l": "9alpha-copalyl diphosphate => 9beta-pimara-7,15-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.32", "l": "\"beta-lytic metalloendopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61557", "l": "gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55456", "l": "ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8944457", "l": "MAF1 translocates to the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68743", "l": "7-oxocholesterol + H(+) + NADPH <=> 7alpha-hydroxycholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676589", "l": "RANKL,sRANKL trimer binds RANK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15523", "l": "CoA + H(+) + N-tetradecanoylglycyl-[protein] => N-terminal glycyl-[protein] + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21923", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine <=> Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33551", "l": "an N-acylsphinganine + H2O = a fatty acid + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004168", "l": "dolichol kinase activity", "d": ["Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40719", "l": "an R-cob(III)alamin + apo-[alkylcobalamin reductase] + glutathione = an S-substituted glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26348", "l": "L-galactonate + NADP(+) <=> aldehydo-D-galacturonate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000327", "l": "PLK1 phosphorylates BORA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67206", "l": "acetate + tryptamine => H2O + N-acetyltryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004679", "l": "AMP-activated protein kinase activity", "d": ["Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45973", "l": "3-oxochol-4-en-22-oate + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427570", "l": "Group 3 - Selective Cl- transport (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17473", "l": "GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)", "d": []}, {"i": "EC:3.5.4.16", "l": "\"GTP cyclohydrolase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10805", "l": "(S)-allantoin => (R)-allantoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21877", "l": "(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) => (S)-usnate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10798", "l": "albendazole S-oxide + H2O + NADP(+) => albendazole + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54642", "l": "(12E)-labda-8(17),12,14-triene + diphosphate => (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191763", "l": "snRNP:Snurportin complex formation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35231", "l": "rifampicin(in) = rifampicin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22697", "l": "AH2 + androst-4-ene-3,17-dione + O2 => A + H2O + testololactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174438", "l": "Formation of the Flap Intermediate on the C-strand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3244647", "l": "cGAS binds cytosolic DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16558", "l": "2-amino-3-carboxymuconate 6-semialdehyde + H(+) => 2-aminomuconate 6-semialdehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52906", "l": "ADP + coenzyme F430 + phosphate => 15,17(3)-seco-F430-17(3)-acid + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781941", "l": "WNTs are secreted in exosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41821", "l": "butanoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139905", "l": "Translocation of activated BAD protein to mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2250301", "l": "Formation of lysyl-pyrrole cross-links (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809764", "l": "SBF1 binds MTMR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46614", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19694", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) => 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57392", "l": "(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine = 3-O-acetyl-4'-O-demethylpapaveroxine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.44", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950741", "l": "IL12B:IL23A translocates from ER lumen to extracellular space (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381668", "l": "cAMP activates EPAC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67646", "l": "ADP + dZTP => ATP + dZDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48636", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0061783", "l": "peptidoglycan muralytic activity", "d": ["A catalytic activity that contributes to the degradation of peptidoglycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026377", "l": "NTF4-bound NTRK2 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64535", "l": "an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106438", "l": "protein-glutamic acid ligase activity, elongating", "d": ["Catalytic reaction :(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate."]}, {"i": "RHEA:60148", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17470", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23938", "l": "5-dehydro-D-gluconate + H(+) + NADPH => D-gluconate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23391", "l": "ATP + hygromycin B <=> 7''-O-phosphohygromycin B + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050661", "l": "NADP binding", "d": ["Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443894", "l": "TXA2 is hydrolysed to TXB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050441", "l": "3-ethylmalate synthase activity", "d": ["Catalysis of the reaction: butanoyl-CoA + glyoxylate + H2O = 3-ethylmalate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018804", "l": "RAC3 GEFs activate RAC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51660", "l": "an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 = an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33915", "l": "4-(methylamino)butanoate + H2O + O2 = H2O2 + methylamine + succinate semialdehyde", "d": []}, {"i": "EC:1.5.3.21", "l": "\"4-methylaminobutanoate oxidase (methylamine-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031736", "l": "CCR11 chemokine receptor binding", "d": ["Binding to a CCR11 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41813", "l": "(2E)-butenoyl-[ACP] + H(+) + NADPH => butanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43109", "l": "2 Fe(III)-[cytochrome c] + H2O + N2 => 2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44039", "l": "12,13-epoxy-(9Z)-octadecenoate + H2O <=> 12,13-dihydroxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49170", "l": "8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27850", "l": "glycine + phenylacetyl-CoA = CoA + H(+) + phenylacetylglycine", "d": []}, {"i": "EC:2.3.1.192", "l": "\"glycine N-phenylacetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12547", "l": "2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine <=> 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44410", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64731", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61960", "l": "a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73605", "l": "CMP(out) + CTP(in) => CMP(in) + CTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30300", "l": "2-oxoglutarate + a methylated nucleobase within DNA + O2 => a nucleobase within DNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61414", "l": "ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine => ATP + N-(D-erythrulosyl)-cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63297", "l": "an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56543", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol <=> 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52463", "l": "17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354073", "l": "Autophosphorylation of PTK2 at Y397 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64077", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706312", "l": "Active FLT3 binds to LCK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72701", "l": "NAD(+) + propanoate => acrylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734730", "l": "ORC1 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13278", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate => [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45602", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) => D-galactaro-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69389", "l": "(S)-2-ureidoglycine + carbamoyl phosphate => allantoate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015643", "l": "toxic substance binding", "d": ["Binding to a toxic substance, a poisonous substance that causes damage to biological systems."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67886", "l": "adenosine 3',5'-bisphosphate + dopamine 4-O-sulfate + H(+) => 3'-phosphoadenylyl sulfate + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106099", "l": "2-keto-3-deoxy-L-rhamnonate aldolase activity", "d": ["Catalysis of the reaction 2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013021", "l": "GDIs block activation of RHOB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49397", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35885", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46746", "l": "ADP + carboxyphosphate => ATP + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451811", "l": "YKI binds to WTS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.75", "l": "\"lysostaphin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21549", "l": "H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] => acetate + L-lysyl-[alpha-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.31", "l": "\"DNA nucleotidylexotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.623042282429068", "identifiers": [{"i": "GO:0051213", "l": "dioxygenase activity", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38666", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41005", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869568", "l": "NPM1 binds TFAP2A homodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14109", "l": "L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77077", "l": "Capping complex formation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18465", "l": "L-dopa + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": []}, {"i": "EC:1.13.11.30", "l": "\"stizolobinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687107", "l": "MAPK4,6 translocate to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43431", "l": "1,2-didecanoyl-sn-glycerol + ATP <=> 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66282", "l": "H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP => solanidine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48585", "l": "2 H2O + 2 leukotriene A4 + O2 => 2 lipoxin A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53861", "l": "7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+) => dehydrocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42659", "l": "diphthine methyl ester-[translation elongation factor 2] + H2O <=> diphthine-[translation elongation factor 2] + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42339", "l": "[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865774", "l": "TTLLs polyglutamylate tubulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43160", "l": "adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.223", "l": "\"tRNA1(Val) (adenine(37)-N(6))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250930", "l": "B-WICH recruits histone acetyltransferases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71611", "l": "(S)-malate(in) + malonate(out) = (S)-malate(out) + malonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53542", "l": "(13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine => (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11971", "l": "AH2 + kynurenate + O2 <=> 7,8-dihydro-7,8-dihydroxykynurenate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15331", "l": "H(+) + N-carbamoyl-2-oxoglycine + NADH => (S)-ureidoglycolate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169192", "l": "PTP1B dephosphorylates GHR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797553", "l": "Protein 4.1 binds CASK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.70", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42213", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O => a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11718", "l": "a dicarboxylate + NH4(+) => a monoamide of a dicarboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47127", "l": "glycine + hexacosanoate <=> H2O + N-hexacosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36354", "l": "AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine <=> 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63602", "l": "L-isoleucine + neocasomorphin-(1-5) => H2O + neocasomorphin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37744", "l": "dimethylallyl phosphate + FMNH2 => phosphate + prenyl-FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373717", "l": "DCC interacts with DIP13alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72671", "l": "eIF5B:GTP is hydrolyzed and released (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782820", "l": "USP17 deubiquitinates SUDS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53573", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71870", "l": "glycodeoxycholate(out) <=> glycodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56956", "l": "ITP + pyruvate = H(+) + IDP + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189381", "l": "BIL translocates from the cytosol to the ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17151", "l": "an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an organic molecule + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36694", "l": "octadecanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416516", "l": "GRK2 sequesters activated Gq (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18098", "l": "pteridine-2,4,6,7-tetrol => H(+) + xanthine-8-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797100", "l": "CCNK binds CDK13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47832", "l": "ganglioside GD1a + H2O = ganglioside GM1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.16", "l": "\"neurolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611851", "l": "ADRB2 bind ADR,NAd (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672817", "l": "Active MTORC1 binds the ULK1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50238", "l": "17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + pregnenolone + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003860", "l": "3-hydroxyisobutyryl-CoA hydrolase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000832", "l": "inositol hexakisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028815", "l": "p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38675", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964842", "l": "Shikimate results from hydration of DHS (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098625", "l": "methylselenol reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + CH3SeOH => NADP+ + CH3SeH + H2O."]}, {"i": "REACT:R-HSA-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72374", "l": "dehydroepiandrosterone 3-sulfate(out) + succinate(in) <=> dehydroepiandrosterone 3-sulfate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63489", "l": "9,10-phenanthroquinone + H(+) + NADPH => NADP(+) + phenanthrene-9,10-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16254", "l": "(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) => H(+) + NADH + phenanthrene-3,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164696", "l": "Chico is phosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611751", "l": "β1,2-agonists bind ADRB1,2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14750", "l": "1-hydroxy-2-naphthoate + O2 => (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218812", "l": "FYN phosphorylates PAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59847", "l": "(+)-dehydrodiconiferyl alcohol + H(+) + NADPH <=> (R)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696465", "l": "USP45 deubiquitinates ERCC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140769", "l": "ACP-dependent peptidyl-lysine N6-myristoyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl-[protein] + tetradecanoyl-[ACP] = H+ + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]."]}, {"i": "RHEA:70611", "l": "L-lysyl-[protein] + tetradecanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31577", "l": "8-oxo-dGMP + diphosphate + H(+) => 8-oxo-dGTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75219", "l": "H2O + L-fucono-1,5-lactone = H(+) + L-fuconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.69", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60029", "l": "(2E)-geranyl diphosphate + H2O => 4-terpineol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59920", "l": "(2E)-octenal + H2O + NAD(+) = (2E)-octenoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62268", "l": "(R)-2-hydroxy-3-methylbutyrate + NADP(+) = 3-methyl-2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781922", "l": "USP13 binds UFD1L:SKP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684275", "l": "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433415", "l": "Activation of RAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43525", "l": "L-allo-threonine + NADP(+) => aminoacetone + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709109", "l": "DHFR dimer binds DHFR inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69400", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690702", "l": "LYN phosphorylates CD22 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030756", "l": "isoorientin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + isoorientin = S-adenosyl-L-homocysteine + H+ + isoscoparin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983421", "l": "Journey of cargo through Golgi complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29484", "l": "(2E,6E)-farnesyl diphosphate => (+)-beta-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50149", "l": "a fatty acid ethyl ester + H2O => a fatty acid + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51094", "l": "10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.8.1", "l": "\"short-chain acyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010681", "l": "PKC phosphorylates ROBO3.1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0030343", "l": "vitamin D3 25-hydroxylase activity", "d": ["Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66546", "l": "H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein] => L-cysteinyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807144", "l": "HTN1,HTN3 or HTN5 binds the bacterial anionic surface  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810076", "l": "DDO oxidizes D-Asp to OA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433950", "l": "TRAF6 recruits TAK1 kinase complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004640", "l": "phosphoribosylanthranilate isomerase activity", "d": ["Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876472", "l": "NPC2 binds CHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265177", "l": "Exocyst complex formation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72075", "l": "ATP + gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine = ADP + H(+) + ophthalmate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66188", "l": "3',5'-cyclic GMP(in) + ATP + H2O = 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18109", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.42", "l": "\"geranylgeranylglycerol-phosphate geranylgeranyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050101", "l": "mimosinase activity", "d": ["Catalysis of the reaction: L-mimosine + H2O = 3-hydroxy-4H-pyrid-4-one + L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24786", "l": "3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 => 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814555", "l": "Integrator complex processes the 3' end of snRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62350", "l": "H2O + NADP(+) + notoamide C => H(+) + NADPH + notoamide E + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679239", "l": "ULK complex translocates to the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27828", "l": "L-homocysteine + succinate => hydrogen sulfide + O-succinyl-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33173", "l": "D-maltose(out) => D-maltose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700168", "l": "Active ALK phosphorylates IRS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25068", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH => (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52839", "l": "H(+) + indole + NADH + O2 <=> H2O + indoxyl + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41033", "l": "1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72103", "l": "Formation of pre-mRNPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20133", "l": "3-(indol-3-yl)lactate + NAD(+) = H(+) + indole-3-pyruvate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57271", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP <=> GMP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912379", "l": "Transport of fringe-modified NOTCH to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35942", "l": "brevianamide F + dimethylallyl diphosphate <=> diphosphate + tryprostatin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944236", "l": "Association of procollagen type XIV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.97", "l": "\"assemblin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34251", "l": "1-deoxysphinganine + NADP(+) = 1-deoxy-3-dehydrosphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047256", "l": "lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity", "d": ["Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57023", "l": "apulose + ATP <=> ADP + apulose 4-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001063", "l": "glucomannan binding", "d": ["Binding to glucomannan."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097604", "l": "temperature-gated cation channel activity", "d": ["Enables the transmembrane transfer of a cation by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420274", "l": "GIP receptor binds gastric inhibitory peptide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0030492", "l": "hemoglobin binding", "d": ["Binding to hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53741", "l": "[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O => [Rab1 protein]-L-tyrosine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444171", "l": "Receptor FFAR2 binds carboxylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451418", "l": "Pellino ubiquitinates IRAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68520", "l": "(2E,6E)-farnesyl diphosphate = beta-acoradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10601", "l": "prostaglandin H2 => prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419490", "l": "Binding of ATP to P2X receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27434", "l": "2 glutathione amide + NAD(+) => glutathione amide disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37110", "l": "H2O + N(7)-methyl-GMP <=> N(7)-methylguanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003935", "l": "GTP cyclohydrolase II activity", "d": ["Catalysis of the reaction: GTP + 3 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65661", "l": "A + calciol + H2O => AH2 + calcidiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65244", "l": "(2S)-hesperetin + UDP-alpha-D-glucose = (2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38450", "l": "4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O <=> 4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11411", "l": "H(+) + H2O + riboflavin <=> lumichrome + ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.945916858897462", "identifiers": [{"i": "GO:0016641", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33647", "l": "(9Z)-hexadecenoate + ATP + CoA = (9Z)-hexadecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "54.94117494528583", "identifiers": [{"i": "GO:0016788", "l": "hydrolase activity, acting on ester bonds", "d": ["Catalysis of the hydrolysis of any ester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14540", "l": "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O <=> 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33419", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA = [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.38", "l": "\"(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217097", "l": "Formation of the Rad17-RFC alternate clamp-loader complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015306", "l": "sialate:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + cation(out) = sialate(in) + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420688", "l": "GABAB heterodimeric receptor binds GABA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50310", "l": "11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69069", "l": "AH2 + 2 N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline => A + 2 N(delta)-hydroxy-N(omega)-methyl-L-citrulline + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53080", "l": "4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799097", "l": "ATM phosphorylates ZNF420 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209370", "l": "CI75 transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35011", "l": "D-fucose(in) + H(+)(in) = D-fucose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444661", "l": "HCAR2 binds HCAR2 ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55438", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol => ferruginol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54765", "l": "5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine => [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16045", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051064", "l": "TTP reductase activity", "d": ["Catalysis of the reaction: dTTP + thioredoxin disulfide + H2O = TTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052608", "l": "echinenone 3-hydroxylase activity", "d": ["Catalysis of the reaction: echinenone + a reduced electron acceptor + oxygen = 3-hydroxyechinenone + an oxidized electron acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52972", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] = a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23588", "l": "oxalate + succinyl-CoA = oxalyl-CoA + succinate", "d": []}, {"i": "EC:2.8.3.2", "l": "\"oxalate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389348", "l": "Activation of Rac1 by pVav1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008684", "l": "TBK1 phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682010", "l": "ATG10:ATG12 binds ATG5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10377", "l": "ATP + Cu(2+)(in) + H2O => ADP + Cu(2+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963872", "l": "VD3 translocates from ER membrane to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663245", "l": "NR1D1 (REV-ERBA) binds heme, the NPAS2 gene, and recruits corepressors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019165", "l": "thiamine kinase activity", "d": ["Catalysis of the reaction: ATP + thiamine = ADP + 2 H+ + thiamine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450422", "l": "KSRP recruits RNA degradation activities (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28460", "l": "biotin(out) => biotin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47943", "l": "ganglioside GM2 (d18:1(4E)) + H2O <=> ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750226", "l": "NLRC5 binds IKBKB and CHUK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191072", "l": "Synthesis of Cx43 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52268", "l": "3-(aminomethyl)indole + S-adenosyl-L-methionine = (1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985091", "l": "OAS3 produces oligoadenylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013435", "l": "RHOD auto-activates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029460", "l": "PAK1 phosphorylates LIMK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102951", "l": "indole-3-acetyl-phenylalanine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-phenylalanine + ATP = H+ + indole-3-acetyl-phenylalanine + AMP + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40368", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047576", "l": "4-chlorobenzoate dehalogenase activity", "d": ["Catalysis of the reaction: 4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0005219", "l": "ryanodine-sensitive calcium-release channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts."]}, {"i": "REACT:R-HSA-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2203479", "l": "STAB2 (FEEL-2) binds ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299297", "l": "Activation of THIK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199093", "l": "CXADR binds to AMICA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62370", "l": "Fe(2+)(in) + 2 hydrogencarbonate(in) => Fe(2+)(out) + 2 hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378956", "l": "Luteinizing hormone is a heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174121", "l": "Association of Securin with Cdc20:APC/C complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112755", "l": "SOCS3 binds IL6ST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46364", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48370", "l": "beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813749", "l": "ALDH1A1 oxidises GA to DGA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69152", "l": "Removal of remaining Flap (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034806", "l": "benzo(a)pyrene 11,12-dioxygenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-11,12-dihydrodiol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029468", "l": "Conversion of PA into DAG by PAP-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70241", "l": "PCK1 phosphorylates OA to yield PEP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56248", "l": "1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36897", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61742", "l": "H(+) + steviolbioside + UDP => steviolmonoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5323526", "l": "FRAT proteins bind GSK3beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16089", "l": "H2O + phosphoethanolamine = ethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "50.203413613956464", "identifiers": [{"i": "GO:0008324", "l": "monoatomic cation transmembrane transporter activity", "d": ["Enables the transfer of cation from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167147", "l": "Separation of abortive HIV-1 transcript from template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40752", "l": "(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate => 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64318", "l": "2 (+)-geodin + 2 H2O => 2 dihydrogeodin + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27898", "l": "3'-AMP + H2O = adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54138", "l": "5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA precursor + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956639", "l": "RUNX1 binds YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26524", "l": "2-methyl-trans-aconitate + H2O => (2S,3S)-2-methylcitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192123", "l": "CYP27A1 27-hydroxylates CHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011950", "l": "Estrogen-responsive GREB1 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26307", "l": "2-aminomuconate 6-semialdehyde => 2-aminophenol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16455", "l": "2-formylbenzoate + pyruvate => (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047323", "l": "[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity", "d": ["Catalysis of the reaction: ATP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) = ADP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759709", "l": "CNBP binds SARS-CoV-2 G-rich RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17006", "l": "ATP + D-glucuronate => 1-phospho-alpha-D-glucuronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39606", "l": "(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA <=> (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15524", "l": "N-terminal glycyl-[protein] + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoylglycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21282", "l": "H(+) + 2 H2O2 + thiamine acetate => H2O + 2 O2 + thiamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43834", "l": "3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate => 5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141439", "l": "Release of activated MAD2 from kinetochores (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9680443", "l": "ROCK1,2 bind ROCKi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683113", "l": "Defective ABCC8 does not form functional KATP channels, causing hyperinsulinemic hypoglycemia (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22501", "l": "(E)-feruloyl-CoA + H(+) + malonyl-CoA => (E)-feruloylacetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52018", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72190", "l": "H(+)(out) + sucrose(out) <=> H(+)(in) + sucrose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74194", "l": "carbofuran + H(+) + H2O <=> 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-ol + CO2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446322", "l": "PARVA associates with Paxillin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.11", "l": "\"serine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689111", "l": "PARK2 autoubiquitinates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046936", "l": "2'-deoxyadenosine deaminase activity", "d": ["Catalysis of the reaction: 2'-deoxyadenosine + H2O = deoxyinosine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936642", "l": "deacetylation of O-acetylserine and sulfhydrylation using CysK1 (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72344", "l": "3-methoxyphenol + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + resorcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050584", "l": "linoleate 11-lipoxygenase activity", "d": ["Catalysis of the reaction: linoleate + O2 = (9Z,11S,12Z)-11-hydroperoxyoctadeca-9,12-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21857", "l": "cyclohexa-1,5-diene-1-carbonyl-CoA + H2O => 6-hydroxycyclohex-1-ene-1-carbonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022870", "l": "protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71538", "l": "D-glucose 6-phosphate(in) + phosphate(out) <=> D-glucose 6-phosphate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48074", "l": "ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GM1 (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72147", "l": "AH2 + S-adenosyl-L-methionine + UTP = 3'-deoxy-3',4'-didehydro-UTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47186", "l": "7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48178", "l": "(2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein] => decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000250", "l": "lanosterol synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48539", "l": "1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O <=> 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873929", "l": "Casein kinase II phosphorylates STARD10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.101", "l": "\"acylglycerone-phosphate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13307", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + UDP => (E)-sinapate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944522", "l": "miR-19a microRNA binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50935", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 <=> (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23603", "l": "2-oxoglutarate + L-2-aminohexanoate <=> 2-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030604", "l": "1-deoxy-D-xylulose-5-phosphate reductoisomerase activity", "d": ["Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54269", "l": "2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 => (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.164", "l": "\"galactan endo-1,6-beta-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56842", "l": "(2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+) => 5-amino-2-hydroxybenzoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27909", "l": "butanoyl-CoA + NADP(+) <=> (2E)-butenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60714", "l": "(+)-artemisinic aldehyde + H(+) + NADH => (+)-artemisinic alcohol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68647", "l": "(2E)-geranyl diphosphate <=> alpha-thujene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30509", "l": "2-demethylmenaquinol-8 + NAD(+) => 2-demethylmenaquinone-8 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73432", "l": "(2S)-sakuranetin + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-7-methylcarthamidin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111264", "l": "Addition of nucleotides between position +11 and +30 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19419", "l": "[phosphate](n+1) + a dolichyl phosphate => [phosphate](n) + a dolichyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13742", "l": "3-phenylpyruvate + L-tryptophan => indole-3-pyruvate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9017797", "l": "NOTCH3 binds YBX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28398", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate = L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70457", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2 => (6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.386", "l": "\"ipsdienol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21414", "l": "dihydroxyacetone phosphate + H(+) + NADH => NAD(+) + sn-glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66943", "l": "acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine <=> 12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797974", "l": "LRRTMs bind NRXNs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73278", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine <=> 4',7,8-trihydroxy-3'-methoxyflavone-7-olate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51014", "l": "a monoacylglycerol + H(+) + phosphocholine => a monoacyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34030", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) <=> (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56945", "l": "AH2 + D-ribulose 5-phosphate => 1-deoxy-D-xylulose 5-phosphate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13850", "l": "D-arabinose => D-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008453", "l": "alanine-glyoxylate transaminase activity", "d": ["Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30919", "l": "A + rhodopin = (3E)-3,4-didehydrorhodopin + AH2", "d": []}, {"i": "EC:1.3.99.27", "l": "\"1-hydroxycarotenoid 3,4-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73110", "l": "acacetin + S-adenosyl-L-methionine <=> apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58671", "l": "3-deoxyfructose + NADP(+) <=> 3-deoxyglucosone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18448", "l": "H2O + IMP <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65111", "l": "aculene C + L-prolyl-[peptidyl-carrier protein] <=> aculene A + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11779", "l": "2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] <=> (9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39786", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71339", "l": "chloride(out) + L-tyrosine(out) + 2 Na(+)(out) = chloride(in) + L-tyrosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36935", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.-", "l": "\"Sulfuric ester hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51816", "l": "ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out) = AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047074", "l": "4-hydroxycatechol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: O2 + benzene-1,2,4-triol = maleylacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173542", "l": "SMURF2 ubiquitinates SMAD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25837", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O => 5-deoxy-D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9617595", "l": "SGTA binds mislocalized membrane protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64951", "l": "dCTP + H2O <=> dCDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351341", "l": "Exocytosis of Proactivator polypeptide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379387", "l": "COMT transfers Met to DA to form 3MT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.3.3", "l": "\"lysine 5,6-aminomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047625", "l": "adenosylmethionine cyclotransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + homoserine lactone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374337", "l": "Apelin receptor binds to apelin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247960", "l": "Activation of p38 MAPK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13195", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate => 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35564", "l": "H2O + N-(9Z-hexadecenoyl) ethanolamine => (9Z)-hexadecenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0005346", "l": "purine ribonucleotide transmembrane transporter activity", "d": ["Enables the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0005354", "l": "galactose transmembrane transporter activity", "d": ["Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose."]}, {"i": "RHEA:34915", "l": "D-galactose(in) = D-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38099", "l": "a ribonucleoside 5'-triphosphate + phytyl phosphate = a ribonucleoside 5'-diphosphate + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62574", "l": "glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine => H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25262", "l": "2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.2.1.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36376", "l": "ATP + carbamoyl phosphate + H2O => carbamoyl adenylate + diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874080", "l": "SRC phosphorylates PTK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004862", "l": "cAMP-dependent protein kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase."]}, {"i": "REACT:R-HSA-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75850", "l": "Addition of the third nucleotide on the nascent transcript (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624956", "l": "PDE6D binds INPP5E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36170", "l": "a 2'-deoxyribonucleoside 5'-phosphate + H2O <=> a 2'-deoxyribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74993", "l": "deoxyerythrostominone(out) => deoxyerythrostominone(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73343", "l": "beta-alanyl-5'-AMP + holo-[peptidyl-carrier protein] = AMP + beta-alanyl-[peptidyl-carrier protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814153", "l": "ADO oxidises 2AET to HTAU (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693608", "l": "Initial resection of double-strand break ends (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77589", "l": "Recognition of AAUAAA sequence by CPSF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102687", "l": "UDP-glucose:dihydrozeatin 7-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + dihydrozeatin <=> H+ + dihydrozeatin-7-N-glucose + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56490", "l": "H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolate + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785213", "l": "LIPC dimer binds heparin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22401", "l": "androstan-3alpha,17beta-diol + NAD(+) => 17beta-hydroxyandrostanone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40159", "l": "H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67811", "l": "L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58181", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH => all-trans-lycopaoctaene + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54270", "l": "(3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate => 2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24740", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => (6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47347", "l": "7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102773", "l": "dihydroceramide kinase activity", "d": ["Catalysis of the reaction: ATP + a dihydroceramide = ADP + H+ + a dihydroceramide 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418456", "l": "cGMP is degraded by PDEs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34904", "l": "4 glutathione + 2 H(+) + selenite => glutathione disulfide + 3 H2O + selenodiglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139920", "l": "Translocation of tBID to mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75789", "l": "GTP(out) => GTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852019", "l": "MET bound PI3K generates PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001001", "l": "mitochondrial single-subunit type RNA polymerase binding", "d": ["Binding to a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097079", "l": "selenite:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: selenite(out) + H+(out) = selenite(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26286", "l": "Co-precorrin-5B + S-adenosyl-L-methionine => Co-precorrin-6A + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61317", "l": "germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43364", "l": "L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose = beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46443", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2 <=> A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3782535", "l": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49260", "l": "D-galactose(out) + N(pros)-phospho-L-histidyl-[protein] = D-galactose 6-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.204", "l": "\"protein-N(pi)-phosphohistidine--D-galactose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450975", "l": "isocitrate <=> citrate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15866", "l": "AH2 + O2 + tryptamine => 4-hydroxytryptamine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23552", "l": "2-methylpropane-1,2-diol + NAD(+) = 2-hydroxy-2-methylpropanal + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.400", "l": "\"2-methyl-1,2-propanediol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805399", "l": "TAF1 phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59707", "l": "D-cellohexaono-1,5-lactone + H2O <=> D-cellohexaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40909", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507870", "l": "Aquaporins passively transport water out of cells (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31205", "l": "3-oxooctanoyl-CoA + CoA => acetyl-CoA + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17196", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56411", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47306", "l": "(2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16448", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone <=> daidzein + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322135", "l": "Defective MMAA does not protect MUT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9676264", "l": "Formation of the SET1B complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807008", "l": "PTPRJ dephosphorylates MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682388", "l": "Autophagosome maturation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73784", "l": "dimethylallyl diphosphate + tardioxopiperazine A => diphosphate + echinulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55315", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35975", "l": "2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 = A + CO2 + H2O + succinate + verruculogen", "d": []}, {"i": "EC:1.14.11.38", "l": "\"verruculogen synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183051", "l": "CBL ubiquitinates Sprouty (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114683", "l": "Phosphorylation of Platelet Sec-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68385", "l": "(2E,6E)-farnesyl diphosphate + L-tryptophyl-[protein] => (2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047648", "l": "alkylamidase activity", "d": ["Catalysis of the reaction: N-methylhexanamide + H2O = hexanoate + methylammonium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16941", "l": "N-acetylindoxyl + O2 = H2O + N-acetylisatin", "d": []}, {"i": "EC:1.7.3.2", "l": "\"acetylindoxyl oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805792", "l": "p-S291-PHF20 translocates to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42731", "l": "S-adenosyl-L-methionine + uridine(2791) in 21S rRNA <=> 2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66779", "l": "ATP + H2O + uroporphyrin III(in) <=> ADP + H(+) + phosphate + uroporphyrin III(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46871", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) <=> a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5333671", "l": "CLCAs self cleave (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40347", "l": "3-oxotetradecanedioyl-CoA + CoA = acetyl-CoA + dodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61381", "l": "2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O => 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70982", "l": "Fumarate + H2O <=> (S)-Malate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73095", "l": "AMP(out) + CoA(in) = AMP(in) + CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44176", "l": "a 2,3-diacyl-sn-glycerol + H2O = 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22067", "l": "5alpha-ergosta-7,22-diene-3beta,5-diol <=> ergosterol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59460", "l": "hexadecan-1-ol + NADP(+) = H(+) + hexadecanal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227698", "l": "NLRX1 inhibits IPS1 signaling (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247836", "l": "Retromer recycles WLS to the Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390329", "l": "Dephosphorylation of AKT by PP2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22658", "l": "CMP + H(+) + L-serine-phosphoethanolamine => CDP-ethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655193", "l": "KIAA0101 double monoubiquitination (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48440", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol = a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56704", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate", "d": []}, {"i": "EC:1.14.20.12", "l": "\"3-[(E)-2-isocyanoethenyl]-1H-indole synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008740", "l": "L-rhamnose isomerase activity", "d": ["Catalysis of the reaction: L-rhamnose = L-rhamnulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877620", "l": "ECE2 cleaves EDN1(53-90) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018798", "l": "RHOV binds GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005289", "l": "high-affinity L-arginine transmembrane transporter activity", "d": ["Enables the transfer of arginine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57728", "l": "H(+) + trans-aconitate = CO2 + itaconate", "d": []}, {"i": "EC:4.1.1.113", "l": "\"trans-aconitate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.30", "l": "\"[heparan sulfate]-glucosamine 3-sulfotransferase 3\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56197", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose => H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49024", "l": "L-tryptophan + O2 = 2-iminio-3-(indol-3-yl)propanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75451", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37276", "l": "H2O + L-alanyl-L-glutamine => L-alanine + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10569", "l": "luteolin + UDP-alpha-D-glucuronate => H(+) + luteolin 7-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67795", "l": "ribonucleotidyl-uridine-RNA <=> a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60195", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60332", "l": "L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24620", "l": "NAD(+) + octan-1-ol = H(+) + NADH + octanal", "d": []}, {"i": "EC:1.1.1.73", "l": "\"octanol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706350", "l": "FLT3 phosphorylates CBL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937419", "l": "CBR3 reduces DOX to DOXOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71621", "l": "(S)-malate(out) + 2 thiosulfate(in) => (S)-malate(in) + 2 thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53469", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol => (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043881", "l": "mesaconyl-CoA hydratase activity", "d": ["Catalysis of the hydration of mesaconyl-CoA to beta-methylmalyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635861", "l": "NUMB:ITCH binds GLI1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56118", "l": "3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-decaprenylphenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51218", "l": "adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+) => 3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35459", "l": "cholesterol + NAD(+) = cholest-5-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48590", "l": "2 lipoxin B4 => 2 H2O + 2 leukotriene A4 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097160", "l": "polychlorinated biphenyl binding", "d": ["Binding to a polychlorinated biphenyl (PCB), a biphenyl compound containing between 2 and 10 chlorine atoms attached to the two benzene rings."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43818", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69936", "l": "guanosine(out) + Na(+)(out) => guanosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54158", "l": "[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50664", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.9", "l": "\"T4 deoxyribonuclease IV\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18870", "l": "ATP + L-xylulose => ADP + H(+) + L-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371591", "l": "Trimerization of cytosolic HSF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19878", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047593", "l": "6-acetylglucose deacetylase activity", "d": ["Catalysis of the reaction: 6-acetyl-D-glucose + H2O = D-glucose + acetate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67876", "l": "3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine = 3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65909", "l": "3-hydroxy-L-kynurenine + pyruvate => H2O + L-alanine + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62397", "l": "(1S,2S)-pseudoephedrine + NAD(+) => (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60027", "l": "(R,R)-chrysanthemyl diphosphate + H2O <=> (R,R)-chrysanthemol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3640862", "l": "Tankyrase binds AXIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635848", "l": "GLI proteins bind PTCH1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428917", "l": "G13 activation by TP receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70535", "l": "GDP-beta-L-fucose + L-seryl-[EGF-like domain protein] = 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727607", "l": "MME:Zn2+ binds sacubitrilat (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46786", "l": "a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61472", "l": "a sphingoid base + hexadecanoyl-CoA = an N-hexadecanoyl-sphingoid base + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.291", "l": "\"sphingoid base N-palmitoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.-", "l": "\"Other intramolecular oxidoreductases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53959", "l": "gamma-L-glutamyl-[BtrI ACP] + H(+) <=> 4-aminobutanoyl-[BtrI ACP] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25649", "l": "(2R,5R)-isopulegone + NADP(+) = (6R)-isopiperitenone + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.82", "l": "\"(-)-isopiperitenone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265301", "l": "Corticotropin cleavage from POMC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374662", "l": "Translocation of Ezrin to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19677", "l": "9'-cis-neoxanthin + O2 = (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69757", "l": "(E)-2-aminocinnamoyl-CoA + CO2 + H2O2 => (2-aminobenzyl)malonyl-CoA + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35586", "l": "2-dehydro-3-deoxy-D-gluconate <=> D-glyceraldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41432", "l": "3-methyl-L-tyrosine + H2O2 = 5-hydroxy-3-methyl-L-tyrosine + H2O", "d": []}, {"i": "EC:1.11.2.5", "l": "\"3-methyl-L-tyrosine peroxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11750", "l": "4-fluoro-L-threonine + acetaldehyde => fluoroacetaldehyde + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18829", "l": "4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.290", "l": "\"4-phosphoerythronate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62812", "l": "4 monapinone A + O2 = 2 dinapinone A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75600", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => ectocarpin A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10332", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": []}, {"i": "EC:2.3.1.62", "l": "\"2-acylglycerophosphocholine O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75144", "l": "prosolanapyrone III => solanapyrone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52978", "l": "a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin] => a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45073", "l": "(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] => (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36343", "l": "2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 = 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828028", "l": "Expression of CXCR4 in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204169", "l": "PDP dephosphorylates p-lipo-PDH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047892", "l": "flavone apiosyltransferase activity", "d": ["Catalysis of the reaction: UDP-apiose + 7-O-beta-D-glucosyl-5,7,4'-trihydroxyflavone = UDP + 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0061133", "l": "endopeptidase activator activity", "d": ["Binds to and increases the activity of an endopeptidase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1449687", "l": "Corticosteroids bind to CBG in blood (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32422", "l": "(1S,2R,4R)-neoisodihydrocarveol + NAD(+) <=> (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636375", "l": "SecA2 transports SapM from cytoplasm to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17765", "l": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+)", "d": []}, {"i": "EC:5.4.2.4", "l": "\"bisphosphoglycerate mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58614", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-octanoylglycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72542", "l": "3,4-dihydroxybenzaldehyde + H2O + NADP(+) <=> 3,4-dihydroxybenzoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13316", "l": "H2O + O2 + sarcosine <=> formaldehyde + glycine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60623", "l": "N-hexanoyl-sphing-4-enine-1-phosphocholine <=> choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264435", "l": "Dissociation of the COP1-p53 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687103", "l": "FOXO3 regulates MIR34B,C expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050641", "l": "6-methylsalicylic acid synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + 3 H+ + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46024", "l": "H2O2 + tetradecanoate = (3R)-hydroxytetradecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20482", "l": "3'-phosphoadenylyl sulfate + coelenterazine h => adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507873", "l": "Aquaporins passively transport urea out of cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964280", "l": "Active Gq binds BTK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70057", "l": "2-hydroxy-4-methoxybenzoate + A + N2 => AH2 + cremeomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20946", "l": "caffeine + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034814", "l": "7,8-dihydroxy benzo(a)pyrene dioxygenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene-cis-7,8-dihydrodiol + O2 = cis-4-(7-hydroxypyren-8-yl)-2-oxobut-3-enoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2995334", "l": "COX15 transforms heme O to heme A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789092", "l": "NOX2 generates superoxide anion from oxygen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60927", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 <=> CO2 + formaldehyde + L-lysyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067640", "l": "IL6 binds IL6R-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791235", "l": "GADD45A binds AURKA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11919", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) <=> 15-oxoprostaglandin E2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.327400668044291", "identifiers": [{"i": "GO:0004857", "l": "enzyme inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of an enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129357", "l": "Fibrillin C-terminal processing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.55", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169398", "l": "ISGylation of host protein filamin B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675790", "l": "MTORC1 dissociates from ULK complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033732", "l": "pyrroloquinoline-quinone synthase activity", "d": ["Catalysis of the reaction: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 2 H2O + 2 H2O2 + H+ + pyrroloquinoline quinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0005337", "l": "nucleoside transmembrane transporter activity", "d": ["Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675206", "l": "PEA15 binds MAPK monomers and dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.780700721499244", "identifiers": [{"i": "GO:0008170", "l": "N-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74106", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56303", "l": "[thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein] <=> [thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682826", "l": "LGI1 binds ADAM11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975633", "l": "atROL binds to RBP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63598", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25506", "l": "beta-phellandrene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12544", "l": "2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine = 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate", "d": []}, {"i": "EC:6.3.5.9", "l": "\"hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901982", "l": "maltose binding", "d": ["Binding to maltose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16271", "l": "4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH => aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53281", "l": "D-threose => D-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12361", "l": "(2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine => 13-(2-methylcrotonoyloxy)lupanine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351913", "l": "Caspase-mediated cleavage of TJP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201685", "l": "Beta-catenin is released from the destruction complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61384", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109813", "l": "GRB2-1 binds SOS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3245898", "l": "TCN1 binds correnoids in the circulation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42802", "l": "all-trans-4,4'-diaponeurosporene + 3 FADH2 => 15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74624", "l": "AMP(in) + UMP(out) => AMP(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59831", "l": "H2O + S-inosyl-L-homocysteine <=> inosine + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389756", "l": "AKT interacts and phosphorylates Cot (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34083", "l": "a (3R)-3-hydroxyacyl-CoA = a (3S)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15692", "l": "H(+) + L-2,4-diaminobutanoate <=> CO2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69702", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + H2O <=> beta-D-glucose + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671855", "l": "Phosphorylated LEPR Binds STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28860", "l": "Ag(+)(in) + H(+)(in) => Ag(+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16092", "l": "H2O + phosphoethanolamine <=> ethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202212", "l": "Recruitment of PLC-gamma1 to LAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73515", "l": "UDP(out) + UTP(in) = UDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64467", "l": "L-tyrosyl-[protein] + 2 O2 <=> H(+) + H2O2 + L-topaquinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12273", "l": "H(+) + L-dopa => CO2 + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13885", "l": "H2O + stipitatonate = CO2 + stipitatate", "d": []}, {"i": "EC:4.1.1.60", "l": "\"stipitatonate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.91", "l": "\"flavivirin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19761", "l": "FMN-N(5)-oxide + H(+) + NADH = FMN + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247844", "l": "WNT ligands traffic to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31376", "l": "H(+) + pyrrole-2-carboxylate => 1H-pyrrole + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40173", "l": "(2E)-dodecenoyl-CoA + H2O2 => dodecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.124", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58751", "l": "desmethylnectriapyrone + S-adenosyl-L-methionine <=> H(+) + nectriapyrone + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38409", "l": "(9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13559", "l": "ADP + glutathione + H(+) + phosphate => ATP + gamma-L-glutamyl-L-cysteine + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63177", "l": "(2S)-ibuprofenoyl-CoA => (2R)-ibuprofenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013159", "l": "CDC42 GEFs activate CDC42 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54293", "l": "ATP + L-threonyl-[protein] => 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9015111", "l": "Factor Xa inhibitors binds Xa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23508", "l": "(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate", "d": []}, {"i": "EC:3.5.1.93", "l": "\"glutaryl-7-aminocephalosporanic-acid acylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140592", "l": "histone H3R8 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 8) = S-adenosyl-L-homocysteine + (histone H3-N-methyl-arginine (position 8). This reaction is the addition of a methyl group to the arginine residue at position 8 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018826", "l": "RHOT2 hydrolyzes GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045157", "l": "electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity", "d": ["Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19965", "l": "S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide + H(+)", "d": []}, {"i": "EC:4.4.1.3", "l": "\"dimethylpropiothetin dethiomethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70777", "l": "6-dehydro-D-glucose + FMN + 2 H(+) + H2O + sulfite => 6-sulfo-D-quinovose + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17972", "l": "ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37759", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080013", "l": "(E,E)-geranyllinalool synthase activity", "d": ["Catalysis of the reaction: all-trans-geranyl-geranyl diphosphate + H2O = (E,E)-geranyllinalool + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69347", "l": "(E)-but-1-en-1-SO-peroxol <=> (Z)-butanethial oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15092", "l": "(R)-lactate + A <=> AH2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56522", "l": "2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine => Fe-coproporphyrin III + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31142", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) <=> 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693125", "l": "RHOF binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43449", "l": "H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25190", "l": "chloroacetate + H2O => chloride + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23375", "l": "ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189062", "l": "lactose + H2O => D-glucose + D-galactose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59867", "l": "(indol-3-yl)butanoate + ATP + L-glutamine <=> (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59660", "l": "D-cellotetraose + O2 = D-cellotetraono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209227", "l": "Activated Phospho IRD5:KEY dimer phosphorylates REL in the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53432", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247844", "l": "WNT ligands traffic to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013145", "l": "RAC1 binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848829", "l": "CBL autoubiquitinates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24699", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080016", "l": "(-)-E-beta-caryophyllene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-E-beta-caryophyllene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9648268", "l": "HTR1A binds HTR1A antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247844", "l": "WNT ligands traffic to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56546", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636128", "l": "Translocation of SCP, Triplex (TRI) complex, CVC complex, and Accessory Proteins from the cytoplasm into the nucleous (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.253913141376358", "identifiers": [{"i": "GO:0008227", "l": "G protein-coupled amine receptor activity", "d": ["Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67453", "l": "a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O => 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27903", "l": "caffeine + H2O + ubiquinone-0 => 1,3,7-trimethylurate + ubiquinol-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.245", "l": "\"assimilatory dimethylsulfide S-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61925", "l": "(2S,4R)-ketoconazole(in) + ATP + H2O => (2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74927", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + H(+) + holo-[ACP] = (2E)-butenoyl-[ACP] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031220", "l": "maltodextrin phosphorylase activity", "d": ["Catalysis of the reaction: maltodextrin = glucose-1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40273", "l": "(2E)-tetradecenedioyl-CoA + H2O2 => O2 + tetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66143", "l": "acetyl-CoA + octopamine <=> CoA + H(+) + N-acetyloctopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417829", "l": "P2RY12 binds ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74314", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35811", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol = (-)-medicarpin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61254", "l": "3-methyl-2-oxobutanoate + H2O2 + NH4(+) => H2O + L-valine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61183", "l": "quercetin + UDP-alpha-D-glucose <=> H(+) + quercetin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806417", "l": "TP53 binds the DDB2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74718", "l": "Internalisation of the insulin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34831", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate = N-acyl-15-methylhexadecasphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71557", "l": "5-aminoethyl-dUMP in DNA + CO2 => 5-C(alpha)-glycyl-dTMP in DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15105", "l": "kaempferol + S-adenosyl-L-methionine = H(+) + kaempferide + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.155", "l": "\"kaempferol 4'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63972", "l": "A + dihydropyriculol = AH2 + pyriculol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941895", "l": "Formation of CDK4/6:CCND complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-688137", "l": "RIP2 is K63 polyubiquitinated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141367", "l": "Myristoylation of tBID by NMT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70573", "l": "argininosuccinate <=> fumarate + arginine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23178", "l": "acetyl-CoA + AMP + diphosphate => acetate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28793", "l": "H(+) + NADH + thymine => 5,6-dihydrothymine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19946", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390593", "l": "ATP Hydrolysis By Myosin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22796", "l": "ATP + D-hamamelose = ADP + D-hamamelose 2'-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.102", "l": "\"hamamelose kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052773", "l": "diacetylchitobiose deacetylase activity", "d": ["Catalysis of the reaction: N,N'-diacetylchitobiose (GlcNac2) + H2O = acetate + 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose (GlcN-GlcNAc)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30679", "l": "D-cellobiose + H2O = beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36798", "l": "a ribonucleoside 5'-triphosphate + 2 H2O <=> a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203712", "l": "eNOS associates with Caveolin-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33181", "l": "1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013567", "l": "HES1 gene expression is stimulated by NOTCH3 and STAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380199", "l": "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69838", "l": "campesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S)-22-hydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33435", "l": "fecosterol = episterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199203", "l": "PANK1/3/4 phosphorylate PanK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69379", "l": "2-hydroxydodecanoate + O2 <=> 2-oxododecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674140", "l": "PAQR3 binds inactive RAFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34715", "l": "15-methylhexadecasphing-4-enine + ATP = 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61668", "l": "ATP + CoA + salicylate = 2-hydroxybenzoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.65", "l": "\"salicylate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56023", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62569", "l": "H2O + S-benzyl-L-cysteinylglycine => glycine + S-benzyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70038", "l": "6-deoxotyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.10", "l": "\"steroid C-25 hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28372", "l": "hydrogencarbonate + phosphoenolpyruvate => oxaloacetate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27921", "l": "H2O + NADP(+) + propanal <=> 2 H(+) + NADPH + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047171", "l": "glucarolactone O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: glucarolactone + sinapoyl-CoA = O-sinapoylglucarolactone + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72452", "l": "a dicarboxylate(in) + dehydroepiandrosterone 3-sulfate(out) => a dicarboxylate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32117", "l": "CO2 + succinate + TRIBOA beta-D-glucoside => 2-oxoglutarate + DIBOA beta-D-glucoside + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388596", "l": "Melanocortin receptors bind melanocortins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.119", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14762", "l": "H(+) + hexadecanoyl-CoA + L-serine => 3-oxosphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47680", "l": "D-galactosamine 6-phosphate + H2O = D-tagatopyranose 1-phosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71608", "l": "(S)-malate(in) + phosphate(out) => (S)-malate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55168", "l": "[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0015173", "l": "aromatic amino acid transmembrane transporter activity", "d": ["Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20722", "l": "CoA + H(+) + L-2-aminoadipate + penicillin G => H2O + isopenicillin N + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660663", "l": "Caspase-8 cleaves IL1B precursor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088322", "l": "Defective GNE does not phosphorylate ManNAc to ManNAc-6-P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421457", "l": "Mitochondrial uptake and processing of ALAS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419490", "l": "Binding of ATP to P2X receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41578", "l": "3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+) => dTDP-beta-L-mycarose + erythronolide B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675790", "l": "MTORC1 dissociates from ULK complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187632", "l": "arginine + H2O => ornithine + urea (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9037040", "l": "SRC,FYN phosphorylate NTRK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58098", "l": "glycerol + H(+) + tetracosanoate => 1-tetracosanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24173", "l": "A + a 3-oxo-5beta-steroid => a 3-oxo-Delta(4)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40917", "l": "(9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) => 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046026", "l": "precorrin-4 C11-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352268", "l": "Cleavage of Satb1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316352", "l": "SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015255", "l": "propanediol channel activity", "d": ["Enables the facilitated diffusion of propanediol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141423", "l": "Binding of the MCC complex to the APC/C complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322427", "l": "Beta-catenin recruits CBP/p300 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55374", "l": "H(+) + jasmonate + methanol => H2O + methyl (-)-jasmonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50581", "l": "acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42485", "l": "D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] => D-sorbitol 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392834", "l": "Activation of EPACs by cAMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41561", "l": "(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 => (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786650", "l": "DDHD1,2 hydrolyse PA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28048", "l": "CoA + propanoyl phosphate => phosphate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977629", "l": "Displacement of C2a/Bb by CR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-181567", "l": "botC LC cleaves target cell STX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132276", "l": "Complement factor I inactivates C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682377", "l": "LC3 de-lipidation by ATG4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162092", "l": "carbovir monophosphate + ATP => carbovir diphosphate + ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-481010", "l": "Surface deployment of platelet dense granule membrane components (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9725855", "l": "NR3C2 binds NR3C2 antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44952", "l": "(2E)-octenoyl-CoA + H(+) + NADPH = NADP(+) + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62038", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60635", "l": "all-trans-4-oxoretinol + NAD(+) <=> all-trans-4-oxoretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40457", "l": "(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13383", "l": "a carboxylate + acetyl-CoA => acetate + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863718", "l": "AGFG1 binds VAMP7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629218", "l": "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58735", "l": "5-methyl-CTP + H2O <=> 5-methyl-CMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.335", "l": "\"4-amino-anhydrotetracycline N(4)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24276", "l": "acetate + diphosphate = acetyl phosphate + phosphate", "d": []}, {"i": "EC:2.7.2.12", "l": "\"acetate kinase (diphosphate)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0015315", "l": "organophosphate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + inorganic phosphate(in) = organophosphate(in) + inorganic phosphate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22025", "l": "H2O + NAD(+) + trimethylamine => 2 H(+) + NADH + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70078", "l": "acetyl-CoA + AH2 + H(+) + 3 malonyl-CoA + 2 S-adenosyl-L-methionine <=> A + clavatol + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433786", "l": "Phosphorylation of IRF3 by TBK1 complexed with activated TLR3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866277", "l": "AP-2 directly binds some endocytic cargo (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73668", "l": "(E,E)-piperoyl-CoA + 2-methylpropan-1-amine => (E,E)-piperlonguminine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691174", "l": "RAC1 binds effectors at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428534", "l": "Recruitment of Profilin by Ena/VASP proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28088", "l": "2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate => 2 H2O2 + Reactive Blue 5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21868", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)", "d": []}, {"i": "EC:3.5.4.26", "l": "\"diaminohydroxyphosphoribosylaminopyrimidine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15060", "l": "(9Z)-octadecenoyl-[ACP] + H2O <=> (9Z)-octadecenoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11042", "l": "3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O => D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46141", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32732", "l": "a diacylglycerol + H2O => a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41189", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13879", "l": "an L-alpha-amino acid + L-glutamate 5-semialdehyde => a 2-oxocarboxylate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44877", "l": "a 1,3-diacylglycerol + H2O => 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19186", "l": "glyoxylate + H2O + propanoyl-CoA => 2-hydroxyglutarate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13285", "l": "ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.2", "l": "\"glutamate--cysteine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74121", "l": "delphinidin 3-O-beta-D-galactoside + H(+) + UDP => delphinidin + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73570", "l": "ITP(out) + UTP(in) <=> ITP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68661", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) 17-sulfate + 3'-phosphoadenylyl sulfate => 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) 17-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102188", "l": "4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) + H+ <=> 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174121", "l": "Association of Securin with Cdc20:APC/C complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28072", "l": "diphosphate + Fe(II)-heme o => (2E,6E)-farnesyl diphosphate + H2O + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58995", "l": "(E)-cinnamaldehyde + H2O + O2 <=> (E)-cinnamate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951500", "l": "Dissociation of CANX from nonameric complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803047", "l": "DCD peptide binds bacterial membrane phospholipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18491", "l": "carbamate + CO2 => cyanate + H(+) + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54183", "l": "a long-chain fatty aldehyde + holo-[ACP] + NAD(+) <=> a long-chain fatty acyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34889", "l": "selenate(out) => selenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14448", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68288", "l": "heptanoyl-CoA + L-seryl-[protein] = CoA + O-heptanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64199", "l": "an N-(fatty acyl)-L-lysine + H2O <=> a fatty acid + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15945", "l": "aldehydo-D-glucose 6-phosphate + L-lysyl-[protein] = H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1253343", "l": "WWOX binds ERBB4s80 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70091", "l": "ethanol + o-quinone methide = hydroxyclavatol ethyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210836", "l": "HNF6-dependent synthesis of NEUROG3 protein during morphogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446364", "l": "Migfilin interacts with VASP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102667", "l": "indole-3-acetyl-beta-1-D-glucose hydrolase activity", "d": ["Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + H2O <=> H+ + indole-3-acetate + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48246", "l": "CMP + ganglioside GM1b + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63312", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = 15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40723", "l": "(9E)-octadecenoyl-CoA + H2O = (9E)-octadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41075", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22359", "l": "diphosphate + oxaloacetate <=> CO2 + phosphate + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59967", "l": "L-seryl-[protein] + octanoyl-CoA <=> CoA + O-octanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68460", "l": "3'-phosphoadenylyl sulfate + a phenolic steroid = a phenolic steroid 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}, {"i": "EC:2.8.2.15", "l": "\"steroid sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042011", "l": "interleukin-16 binding", "d": ["Binding to interleukin-16."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785594", "l": "FANCD2 binds FANCI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51860", "l": "(2E)-geranyl diphosphate + umbelliferone = 8-geranylumbelliferone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47326", "l": "3-oxo-3-phenylpropanoate + L-alanine => (S)-3-amino-3-phenylpropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112271", "l": "The receptor:G-protein complex dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952996", "l": "E2F7 forms homodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783530", "l": "gp130:JAKs bind CNTFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110307", "l": "REV1 binds AP-dsDNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52580", "l": "ATP + H2O + Pb(2+)(in) = ADP + H(+) + Pb(2+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993802", "l": "HLCS biotinylates PC:Mn2+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53491", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH <=> 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69014", "l": "5beta-androstane-3beta,17beta-diol + NADP(+) => 5beta-dihydrotestosterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034336", "l": "misfolded RNA binding", "d": ["Binding to an RNA molecule that has assumed an incorrect conformation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45203", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53385", "l": "5,10-methylenetetrahydromethanopterin + NAD(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62922", "l": "1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal => 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49636", "l": "H2O + methylglyoxal + O2 = H(+) + H2O2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59054", "l": "cadaverine + CO2 => D-lysine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035403", "l": "histone H3T6 kinase activity", "d": ["Catalysis of the reaction: histone H3-threonine (position 6) + ATP = histone H3-phosphothreonine (position 6) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 6 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810161", "l": "HOXA3 chromatin is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70252", "l": "beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol => cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2464822", "l": "RDH12 reduces atRAL to atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877369", "l": "RUNX1 and FOXP3 bind the IFNG gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805785", "l": "AKT phosphorylates PHF20 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71992", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => (-)-astellatene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75302", "l": "NAD(+) <=> 2'cADPR + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085027", "l": "Defective GFPT1 does not transfer an amino group from L-Gln to F6P to form GlcN6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797090", "l": "CCNK binds CDK12 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5334827", "l": "SUMO-CRABP2 binds atRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17609", "l": "L-seryl-[sulfatase] + S-adenosyl-L-methionine = 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine", "d": []}, {"i": "EC:1.1.98.7", "l": "\"serine-type anaerobic sulfatase-maturating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416698", "l": "SEMA5A binds to PLXNB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32652", "l": "erythromycin D + S-adenosyl-L-methionine => erythromycin B + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.688704758796746", "identifiers": [{"i": "GO:0050664", "l": "oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule."]}, {"i": "EC:1.6.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951486", "l": "CD46 binds C4b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29274", "l": "a menaquinol + H(+) + trimethylamine N-oxide <=> a menaquinone + H2O + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674532", "l": "AAMP gene expression is positively regulated by VEGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54617", "l": "2-oxoglutarate + heptadecanoyl-CoA + O2 => 2-hydroxyheptadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75764", "l": "(9E,11E)-octadecadienoate + H2O => 10-hydroxy-(11E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656438", "l": "Defective ALDOB does not cleave Fru 1-P to GA and DHAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.3", "l": "\"type I site-specific deoxyribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140948", "l": "histone H3K9 monomethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20640", "l": "D-fructose + D-glucose <=> D-glucono-1,5-lactone + D-sorbitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73233", "l": "2-chloro-6-hydroxy-1,4-benzoquinone + 2 chloride + FAD + 3 H(+) => 2,4,6-trichlorophenol + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47043", "l": "5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] <=> 5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22292", "l": "benzoyl-CoA + 3 H(+) + 3 malonyl-CoA = biphenyl-3,5-diol + 4 CO2 + 4 CoA", "d": []}, {"i": "EC:2.3.1.177", "l": "\"3,5-dihydroxybiphenyl synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964773", "l": "OXGR1 binds 2OG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390846", "l": "D2D3,4 bind to DA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050410", "l": "3-oxolaurate decarboxylase activity", "d": ["Catalysis of the reaction: 3-oxolaurate + H+ = 2-undecanone + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176517", "l": "SULTs transfer (SO4)2- group to PREG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432054", "l": "Aquaporin-1 passively transports water out of cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48852", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69053", "l": "RFC binding displaces Pol Alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103026", "l": "fructose-1-phosphatase activity", "d": ["Catalysis of the reaction: beta-D-fructofuranose 1-phosphate + H2O <=> beta-D-fructofuranose + hydrogenphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23583", "l": "prostaglandin H2 <=> prostaglandin I2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0001064", "l": "single subunit type RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16194", "l": "an (R)-2-haloacid + H2O => a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34947", "l": "(Z)-3-aminoacrylate + H(+) + H2O = 3-oxopropanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0004000", "l": "adenosine deaminase activity", "d": ["Catalysis of the reaction: adenosine + H2O = inosine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420980", "l": "Activation of Ca permeable AMPA receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57113", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004047", "l": "aminomethyltransferase activity", "d": ["Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein."]}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0005432", "l": "calcium:sodium antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51650", "l": "(S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2 => H2O + N(6)-acetyl-L-lysyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.1", "l": "\"CDP-4-dehydro-6-deoxyglucose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50778", "l": "(E)-hex-2-enal + H(+) + NADPH => hexanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69778", "l": "(2E,6E)-farnesyl diphosphate <=> beta-ylangene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34567", "l": "CDP-alpha-D-paratose + NADP(+) = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.342", "l": "\"CDP-paratose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191830", "l": "snRNP nuclear import and release (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70608", "l": "3'-phosphoadenylyl sulfate + 4-ethylphenol => 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26032", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20758", "l": "2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA => (E)-caffeoyl-CoA + D-threo-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14780", "l": "AMP + H(+) + H2O <=> IMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12425", "l": "(3S)-3-hydroxy-L-aspartate => NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55428", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.60", "l": "\"ferruginol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67580", "l": "3'-phosphoadenylyl sulfate + tauro-alpha-muricholate = adenosine 3',5'-bisphosphate + H(+) + tauro-alpha-muricholate 7-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63043", "l": "H2O + lovastatin <=> H(+) + lovastatin carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362549", "l": "Hh-Np traffics to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047795", "l": "cyclohexane-1,2-diol dehydrogenase activity", "d": ["Catalysis of the reaction: trans-cyclohexane-1,2-diol + NAD+ = 2-hydroxycyclohexan-1-one + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35972", "l": "12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate => diphosphate + fumitremorgin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16008", "l": "galactarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9707523", "l": "Hemes bind to BACH1:MAFK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46972", "l": "A + dihydrobisanhydrobacterioruberin = AH2 + bisanhydrobacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392751", "l": "L1 linked to actin cytoskeleton by ankyrin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12356", "l": "D-mannose 6-phosphate = D-fructose 6-phosphate", "d": []}, {"i": "EC:5.3.1.8", "l": "\"mannose-6-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9615249", "l": "ARBs bind AGRT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74551", "l": "H2O + L-seryl-tRNA(Ser) = L-serine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13586", "l": "ATP + butanoate => ADP + butanoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56319", "l": "3-amino-4-hydroxybenzoate + acetyl-CoA <=> 3-acetylamino-4-hydroxybenzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209823", "l": "Tyrosine is hydroxylated to dopa (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50068", "l": "ATP + glycoursodeoxycholate(in) + H2O = ADP + glycoursodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013143", "l": "RAC1 GEFs activate RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798743", "l": "Exocytosis of secretory granule membrane proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51411", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59384", "l": "2-oxoglutarate + 4-amino-L-phenylalanine = 3-(4-aminophenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388831", "l": "Phosphorylation of CD28 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46307", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.44", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12318", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030750", "l": "putrescine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = N-methylputrescine + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209840", "l": "Two DITs combine to form thyroxine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42793", "l": "cholesterol + hexadecanoyl-CoA => cholesteryl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733969", "l": "Bile salts dissociate from FABP6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32314", "l": "L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62975", "l": "acetyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + orsellinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867613", "l": "PICALM binds R-SNAREs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36444", "l": "dihydrochanoclavine-I aldehyde => 6,8-dimethyl-6,7-didehydroergoline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000900", "l": "mRNA regulatory element binding translation repressor activity", "d": ["Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15981", "l": "H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}, {"i": "EC:4.1.1.50", "l": "\"adenosylmethionine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68104", "l": "all-trans-zeaxanthin + O2 = (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805122", "l": "AURKB binds TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031726", "l": "CCR1 chemokine receptor binding", "d": ["Binding to a CCR1 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.51", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043904", "l": "isochorismate pyruvate lyase activity", "d": ["Catalysis of the reaction: isochorismate = salicylate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653957", "l": "Rag dimer formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56127", "l": "A + all-trans-lycopene + dimethylallyl diphosphate + H2O <=> AH2 + diphosphate + nonaflavuxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917693", "l": "ESCRT Disassembly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18835", "l": "4-sulfobenzoate + 2 H(+) + NADH => 4-formylbenzenesulfonate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186780", "l": "Degradation of Ub-SMAD7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0098988", "l": "G protein-coupled glutamate receptor activity", "d": ["Combining with glutamate and transmitting a signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25341", "l": "H(+) + urea <=> isocyanate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168640", "l": "Ubiquitinated IkB is degraded (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68298", "l": "CoA + O-dodecanoyl-L-seryl-[protein] => dodecanoyl-CoA + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418091", "l": "F2R binds ARRB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51450", "l": "alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102232", "l": "acrolein reductase activity", "d": ["Catalysis of the reaction: acrolein + NADPH + H+ <=> propanal + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3159259", "l": "MMAA:MUT binds AdoCbl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56887", "l": "adenosine(32) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32069", "l": "NH4(+) + urate => 8-oxoguanine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21366", "l": "2 6-aminohexanoate => H2O + N-(6-aminohexanoyl)-6-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50790", "l": "(E)-pent-3-en-2-one + H(+) + NADPH => NADP(+) + pentan-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37844", "l": "1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56114", "l": "3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-nonaprenylphenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36777", "l": "alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20120", "l": "ATP + L-rhamnulose <=> ADP + H(+) + L-rhamnulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389842", "l": "TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694367", "l": "Glycosylated M localizes to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73899", "l": "ATP + cadaverine + L-glutamate = ADP + gamma-L-glutamylcadaverine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004342", "l": "glucosamine-6-phosphate deaminase activity", "d": ["Catalysis of the reaction: D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362465", "l": "GHBP binds GHR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17057", "l": "a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.141", "l": "\"galactosylacylglycerol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140770", "l": "CoA-dependent peptidyl-lysine N6-myristoyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H+ + N(6)-tetradecanoyl-L-lysyl-[protein]."]}, {"i": "RHEA:59752", "l": "L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14951", "l": "2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2 => A + H2O + quinoline-4-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.098124162625822", "identifiers": [{"i": "GO:0000166", "l": "nucleotide binding", "d": ["Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730871", "l": "RasGRP interacts with DAG and Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25633", "l": "laricitrin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + syringetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047184", "l": "1-acylglycerophosphocholine O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3204303", "l": "MRE11 binds cytosolic DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15937", "l": "a primary alcohol + NADP(+) = an aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237160", "l": "MTA is cleaved and phosphorylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21804", "l": "ATP + myo-inositol = 1D-myo-inositol 3-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.64", "l": "\"inositol 3-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.142364941642427", "identifiers": [{"i": "GO:0003690", "l": "double-stranded DNA binding", "d": ["Binding to double-stranded DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982807", "l": "JAK2 phosphorylation of GHR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768939", "l": "NPAS4 binds NPAS4 gene enhancer elements (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140930", "l": "fructose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-fructose(out) + Na+(out) = D-fructose(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39043", "l": "22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] = docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019983", "l": "interleukin-9 binding", "d": ["Binding to interleukin-9."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425861", "l": "Activation of Protein Kinase C novel isoforms (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41129", "l": "1-dodecanoyl-sn-glycerol + H(+) + phosphocholine => 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0120020", "l": "cholesterol transfer activity", "d": ["Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55284", "l": "all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28499", "l": "formaldehyde + mycothiol => S-(hydroxymethyl)mycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733744", "l": "MESP1 binds the NKX2-5 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18548", "l": "2-dehydro-3-deoxy-L-arabinonate <=> glycolaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43134", "l": "H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine => N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49998", "l": "(25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22680", "l": "dCTP + H(+) + H2O = dUTP + NH4(+)", "d": []}, {"i": "EC:3.5.4.13", "l": "\"dCTP deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55996", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374680", "l": "L1 trans-homophilic interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25801", "l": "H2O + N(1)-acetylspermine + O2 => 3-acetamidopropanal + H2O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25950", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+) => a 1,2-diacyl-sn-glycerol + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72047", "l": "A + D-alanine + D-allothreonine + D-leucine + 2 L-leucine + L-proline = AH2 + fusahexin + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203567", "l": "palmitoylation of eNOS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9715356", "l": "brigatinib-resistant ALK mutants don't bind brigatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2514865", "l": "cGMP dissociates from CNG channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26092", "l": "(4S)-limonene + H(+) + NADH + O2 <=> H2O + limonene 1,2-epoxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373129", "l": "fumarate + FADH2 <=> succinate + FAD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177284", "l": "PKA phosphorylates PDE4B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59255", "l": "(E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate <=> (E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59822", "l": "adenosine 3'-diphosphate,5'-triphosphate + AMP => 2 ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65574", "l": "(-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65797", "l": "fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690449", "l": "S1PR1 bind S1P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20073", "l": "D-allothreonine = acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56096", "l": "[protein]-C-terminal Gly-Gly + ATP + H(+) = [protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450187", "l": "TAK1 is activated within the TAK1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68634", "l": "2 H(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => 3 H(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47531", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isocholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58725", "l": "adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24528", "l": "(R)-lactaldehyde + NAD(+) = H(+) + methylglyoxal + NADH", "d": []}, {"i": "EC:1.1.1.78", "l": "\"methylglyoxal reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050099", "l": "methylglutamate dehydrogenase activity", "d": ["Catalysis of the reaction: N-methyl-L-glutamate + A + H2O = L-glutamate + AH(2) + formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36246", "l": "(E)-anol + acetate + NADP(+) <=> (E)-coumaryl acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62025", "l": "campesteryl 3-beta-D-glucoside + H2O => campesterol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.423", "l": "\"(1R,2S)-ephedrine 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102591", "l": "delphinidin 7-O-glucoside acyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-glucoside + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> delphinidin 3-O-rutinoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9656891", "l": "OPN1SW binds 11cRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50928", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71189", "l": "3-hydroxy-L-kynurenine(in) + L-tryptophan(out) => 3-hydroxy-L-kynurenine(out) + L-tryptophan(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237160", "l": "MTA is cleaved and phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034581", "l": "4-methyloct-2-enoyl-CoA hydratase activity", "d": ["Catalysis of the reaction: 4-methyloct-2-enoyl-CoA + H2O = 3-hydroxy-4-methyloctanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61346", "l": "3-hydroxypyruvate + H2O2 + NH4(+) => H2O + L-serine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25008", "l": "L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59865", "l": "(indol-3-yl)butanoate + ATP + L-glutamine => (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981355", "l": "RASA1 binds RAS:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1237119", "l": "Acireductone is oxidized to MOB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022886", "l": "channel-forming ionophore activity", "d": ["Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170824", "l": "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32092", "l": "3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine => dTDP + erythromycin D + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111883", "l": "Hydrolysis of phosphatidylcholine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38963", "l": "ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56634", "l": "1,8-cineole + diphosphate => H2O + neryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062064", "l": "box C/D snoRNP complex binding", "d": ["Binding to a box C/D snoRNP complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21400", "l": "2-oxoglutarate + CoA + NADP(+) = CO2 + NADPH + succinyl-CoA", "d": []}, {"i": "EC:1.2.1.52", "l": "\"oxoglutarate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45519", "l": "phycocyanobilin-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46002", "l": "1-tuberculosinyladenosine + diphosphate => adenosine + H(+) + tuberculosinyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.22", "l": "\"3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74281", "l": "a 2-acyl-sn-glycero-3-phosphocholine + a lipid IVB => a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IVA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53590", "l": "16-oxoresolvin D2 + H(+) + NADH => NAD(+) + resolvin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.146", "l": "\"beta-galactofuranosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624112", "l": "CEBPA binds CDK4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341048", "l": "SUMOylation of RXRA with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-555065", "l": "Formation of clathrin coated vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23286", "l": "dimethylallyl diphosphate => isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9620103", "l": "ALDH2 transforms GTN to NO (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42573", "l": "3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) => 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714580", "l": "SLC6A3 binds DRIs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67265", "l": "(2S,4S)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine => (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007926", "l": "ATRX binds DAXX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202692", "l": "PIP3 binds to RhoA and activates it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58201", "l": "2-oxoglutarate + 6-aminohexanoate => 6-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15582", "l": "biochanin A 7-O-beta-D-glucoside + malonyl-CoA => biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62183", "l": "H2O + peregrinol diphosphate <=> diphosphate + viteagnusin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36109", "l": "O-methyl gibberellin A4 + S-adenosyl-L-homocysteine => gibberellin A4 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6796647", "l": "TP53 stimulates CCNK expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66254", "l": "AMP + diphosphate + IC-asc-C7-CoA => ATP + CoA + IC-asc-C7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74117", "l": "an anthocyanidin 3-O-beta-D-galactoside + UDP => an anthocyanidin + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75002", "l": "deoxyerythrostominol(in) <=> deoxyerythrostominol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62126", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + GDP => a 2'-deoxyribonucleoside 5'-phosphate + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56862", "l": "a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP] => a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31921", "l": "3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65550", "l": "alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base => ganglioside Fuc-GM1 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57743", "l": "a 2,3-saturated meromycolyl-[ACP] + NAD(+) <=> a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009541", "l": "ESR1 binds to TFF1 gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59417", "l": "H2O + O2 + tryptamine => H2O2 + indole-3-acetaldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57937", "l": "H2O + isopyridoxal + NAD(+) => 5-pyridoxate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003743", "l": "translation initiation factor activity", "d": ["Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.17", "l": "\"non-specific polyamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10926", "l": "trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide => cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19608", "l": "a chlorophyll + H2O <=> a chlorophyllide + H(+) + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62805", "l": "2 7-demethylsiderin + NADPH + O2 => desertorin A + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033509", "l": "USP9X binds Ub:PEX5L (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64902", "l": "H(+) + phosphate + UDP => H2O + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46406", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785668", "l": "Defective LARGE does not transfer Xyl from UDP-Xyl to GlcA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047061", "l": "glucose-fructose oxidoreductase activity", "d": ["Catalysis of the reaction: D-fructose + D-glucose = D-glucitol + D-glucono-1,5-lactone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213207", "l": "Formation of collagen networks (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.13", "l": "\"(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29064", "l": "a menaquinone + formate + H(+) => a menaquinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140545", "l": "ATP-dependent protein disaggregase activity", "d": ["An ATP-dependent molecular chaperone activity that mediates the solubilization of ordered protein aggregates."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030158", "l": "protein xylosyltransferase activity", "d": ["Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686578", "l": "Activated ATM phosphorylates ABL1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16689", "l": "D-glucose 6-phosphate + H2O = D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61053", "l": "(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] => (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16586", "l": "[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16968", "l": "(2E)-geranyl diphosphate <=> beta-myrcene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47331", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53884", "l": "CDP-alpha-D-glucose + D-glucose 6-phosphate = alpha,alpha-trehalose 6-phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57270", "l": "GMP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27784", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-octaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001761", "l": "beta-alanine transmembrane transporter activity", "d": ["Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18325", "l": "(2E,6E)-farnesyl diphosphate = (+)-amorpha-4,11-diene + diphosphate", "d": []}, {"i": "EC:4.2.3.24", "l": "\"amorpha-4,11-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662823", "l": "PLK2, MAPK14 phosphorylate ADAM17 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51093", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45480", "l": "gamma-hexachlorocyclohexane = (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174202", "l": "Degradation of multiubiquitinated Securin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51301", "l": "(9Z)-octadecenoate + L-phenylalanine => H2O + N-(9Z-octadecenoyl)-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863895", "l": "IKKB phosphorylates SNAP23 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683964", "l": "ATM phosphorylates EYA1-4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74981", "l": "(3R)-3-isocyanylbutanoyl-AMP + diphosphate => (3R)-3-isocyanylbutanoate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5660665", "l": "Caspase-8 binds MALT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20900", "l": "H(+) + H2O + N-benzyloxycarbonylglycine = benzyl alcohol + CO2 + glycine", "d": []}, {"i": "EC:3.5.1.58", "l": "\"N-benzyloxycarbonylglycine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57933", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168886", "l": "Hemopexin binds Hemes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015311", "l": "monoamine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071859", "l": "neuropeptide F receptor binding", "d": ["Binding to a neuropeptide F receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004464", "l": "leukotriene-C4 synthase activity", "d": ["Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36567", "l": "GDP-beta-L-colitose + NAD(+) = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71701", "l": "H(+)(in) + L-phenylalanyl-L-leucine(in) => H(+)(out) + L-phenylalanyl-L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42689", "l": "AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide => A + ergothioneine + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373074", "l": "Receptor CCR9  binds CCL25 ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418553", "l": "cAMP degradation by Phosphodiesterases (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16039", "l": "2-deoxy-alpha-D-ribose 1-phosphate + thymine => phosphate + thymidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38947", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649735", "l": "Intrinsic nucleotide exchange on RAS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10936", "l": "6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate", "d": []}, {"i": "EC:1.8.5.2", "l": "\"thiosulfate dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42390", "l": "beta-D-gentiobiosyl crocetin + H(+) + UDP => beta-D-glucosyl crocetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662466", "l": "XYLB phosphorylates D-xylulose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57631", "l": "3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate <=> H2O + ML-236C carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29563", "l": "ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": []}, {"i": "EC:6.3.2.45", "l": "\"UDP-N-acetylmuramate L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59629", "l": "H2O + N(2)-(4-aminobutanoyl)-L-arginine => 4-aminobutanoate + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016361", "l": "activin receptor activity, type I", "d": ["Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53653", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23105", "l": "D-arabinose 5-phosphate => D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60682", "l": "(+)-artemisinate + 2 H(+) + NADPH => (+)-artemisinic aldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624953", "l": "ARL13B binds INPP5E (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870461", "l": "RABGGTA and RABGGTB bind (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73567", "l": "ITP(out) + UTP(in) = ITP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62857", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66124", "l": "2-oxobutanoate + L-histidine = (2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008510", "l": "sodium:bicarbonate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606160", "l": "p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36219", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48913", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a => CMP + ganglioside GT1a + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65839", "l": "AH2 + ATP + 2 Co(II)-[trimethylamine-specific corrinoid protein] + H2O <=> A + ADP + 2 Co(I)-[trimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654159", "l": "Activated FGFR2 binds PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73978", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689544", "l": "UCHL5 binds INO80 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67773", "l": "a 5'-end 5'-monophospho-ribonucleoside-RNA + H2O => a 5'-end dephospho-ribonucleoside-RNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10823", "l": "D-threo-isocitrate <=> D-erythro-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15972", "l": "2 glutathione + H(+) + methylarsonate <=> glutathione disulfide + H2O + methylarsonous acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11710", "l": "H(+) + NADH + XMP => H2O + IMP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72802", "l": "L-arginine(out) + L-homoarginine(in) <=> L-arginine(in) + L-homoarginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33741", "l": "H2O + hexadecanal + NAD(+) => 2 H(+) + hexadecanoate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014433", "l": "RHOG GEFs activate RHOG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75173", "l": "GDP + H(+) + NADP(+) => GTP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34646", "l": "2 S-adenosyl-L-methionine + squalene <=> 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870466", "l": "RGGT:CHM binds RABs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66161", "l": "hexanoyl-CoA + tyramine => CoA + H(+) + N-hexanoyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432148", "l": "Fgr may phosphorylate p38 MAPK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73653", "l": "CTP(in) => CTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63907", "l": "2 3-phenylpyruvate + H(+) <=> H2O + phenguignardate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749487", "l": "TP53 stimulates IKBIP gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112037", "l": "Inactivation of PLC beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53190", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine => 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.98", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798257", "l": "PTPRS binds NTRK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40491", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59604", "l": "H2O + O2 + spermidine = H2O2 + N-(4-aminobutyl)-3-aminopropanal + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59661", "l": "D-cellotetraose + O2 => D-cellotetraono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047866", "l": "dimethylglycine oxidase activity", "d": ["Catalysis of the reaction: N,N-dimethylglycine + H2O + O2 = formaldehyde + H2O2 + sarcosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-881988", "l": "CRY is phosphorylated by SGG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47670", "l": "2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429157", "l": "ABCC4 accumulation of dense granule contents (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31418", "l": "(2Z,6E)-farnesyl diphosphate <=> (+)-2-epi-prezizaene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604664", "l": "ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21965", "l": "an acylcholine + H2O => a carboxylate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41980", "l": "3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) = 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67546", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine => (9Z)-tetradecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700175", "l": "Active ALK phosphorylates SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2160935", "l": "SMURF1 ubiquitinates RHOA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31369", "l": "H2O + nitrate + 2 nitric oxide => 2 H(+) + 3 nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35051", "l": "N,N'-diacetylchitobiose(out) = N,N'-diacetylchitobiose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65789", "l": "diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13697", "l": "ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.15", "l": "\"ribokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22015", "l": "precorrin-4 + S-adenosyl-L-methionine <=> precorrin-5 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46684", "l": "3-oxochol-4-en-24-oyl-CoA + A = (22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34985", "l": "sulfate(out) => sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68377", "l": "glyoxylate + L-asparagine => 2-oxosuccinamate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64624", "l": "(2E)-geraniol + acetyl-CoA = (2E)-geranyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42504", "l": "2-oxoglutarate + N(6)-acetyl-L-lysine = 6-acetamido-2-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5225649", "l": "RBBP7 binds histone H3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56803", "l": "apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide <=> cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34364", "l": "H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP => diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72254", "l": "(R)-adrenaline + S-adenosyl-L-methionine <=> (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33056", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O => diphosphate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45219", "l": "coenzyme M + methyl-Co(III)-[dimethylamine-specific corrinoid protein] <=> Co(I)-[dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31919", "l": "indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] = 3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.157", "l": "\"indolin-2-one monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375395", "l": "C5a receptor binds C5a anaphylatoxin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65615", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47136", "l": "ATP + CoA + lithocholate = AMP + diphosphate + lithocholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36452", "l": "ATP + glycyl-L-glutamate(out) + H2O => ADP + glycyl-L-glutamate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871226", "l": "RET binds GFRA1,GFRA2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74148", "l": "(S)-2-benzoylsuccinyl-CoA + CoA => benzoyl-CoA + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51823", "l": "ATP(in) + CoA(in) + decanoate(out) + H(+)(out) <=> AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57411", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) <=> 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029270", "l": "Recruitment of PLCgamma to membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64213", "l": "an N-(fatty acyl)-L-isoleucine + H2O => a fatty acid + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174124", "l": "Dephosphorylation of phospho-Cdh1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58582", "l": "acetate + catharanthine + H(+) => dihydroprecondylocarpine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34719", "l": "15-methylhexadecasphing-4-enine 1-phosphate = (2E)-13-methyltetradecenal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209573", "l": "p75NTR:NgR complex interacts with the axonal inhibitor LINGO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701507", "l": "PTPN6 dephosphorylates JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011346", "l": "MSI1 binds ROBO3.1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76097", "l": "(11R)-carlactonoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (11R)-19-oxocarlactone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55342", "l": "1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45006", "l": "CoA + O-2,6-dimethylheptanoyl-(R)-carnitine => (R)-carnitine + 2,6-dimethylheptanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74402", "l": "2 (S)-lactate(in) + prostaglandin F2alpha(out) <=> 2 (S)-lactate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209815", "l": "Tyrosine is monoiodinated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191072", "l": "Synthesis of Cx43 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33911", "l": "an N-alkylglycine + H2O + O2 = an alkylamine + glyoxylate + H2O2", "d": []}, {"i": "EC:1.5.3.20", "l": "\"N-alkylglycine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11243", "l": "ATP + thiamine diphosphate <=> ADP + thiamine triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45690", "l": "N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out) => N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66172", "l": "H(+)(out) + L-cystine(out) = H(+)(in) + L-cystine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675417", "l": "PEBP1 binds activated RAF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16845", "l": "acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10285", "l": "L-leucine => (3R)-beta-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22519", "l": "ATP + taurocyamine <=> ADP + H(+) + N-phosphotaurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34717", "l": "15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+) => 15-methylhexadecasphing-4-enine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140399", "l": "aflatoxin B synthase activity", "d": ["Catalyzes the reaction: 8-O-methylsterigmatocystin + 2 [reduced NADPH--hemoprotein reductase] + 2 O2 <=> aflatoxin B + 2 [oxidized NADPH--hemoprotein reductase] + H2O + methanol + CO2. Produces both aflatoxin B(1) and aflatoxin B(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38047", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211476", "l": "HNF1A-dependent synthesis of GLUT2 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5672011", "l": "p-AMPK:AMP binds the ULK complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0005542", "l": "folic acid binding", "d": ["Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40932", "l": "2-oxoglutarate + L-ornithine + O2 => (3S)-3-hydroxy-L-ornithine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66668", "l": "5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase] = 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58386", "l": "H(+) + NADPH + octanal => NADP(+) + octan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68436", "l": "(3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2 = (3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65856", "l": "A + a 1-hydroxy-3-oxo steroid = a steroid 1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662606", "l": "MT3 binds zinc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43758", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18] => acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709454", "l": "EPOR binds EPOR agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50618", "l": "(3E)-nonen-2-one + H(+) + NADPH => NADP(+) + nonan-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47441", "l": "(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) => 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41681", "l": "a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) => a 2-all-trans-polyprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617815", "l": "BBSome binds RAB3IP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59626", "l": "4-aminobutanoate + L-ornithine => H2O + N(2)-(4-aminobutanoyl)-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.4", "l": "\"alliin lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55454", "l": "daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63346", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate => ATP + L-amino acyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005139", "l": "interleukin-7 receptor binding", "d": ["Binding to an interleukin-7 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849900", "l": "SALMs1-3 bind each other in cis interactions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210892", "l": "cya and lef bind to pagA(197-794):ANTXR2 oligomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58832", "l": "24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}, {"i": "EC:1.14.18.10", "l": "\"plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16759", "l": "H(+) + NADPH + trypanothione disulfide => NADP(+) + trypanothione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46278", "l": "(S)-lactate + CO2 => (S)-malate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55131", "l": "(3R)-hydroxy-5-methylhexanoyl-[ACP] <=> (2E)-5-methylhexenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74276", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid A => a 2-acyl-sn-glycero-3-phosphocholine + a hepta-acyl lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465924", "l": "OPN1LW binds 11cRAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44626", "l": "dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH => dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41663", "l": "dihydrosanguinarine + NAD(+) <=> NADH + sanguinarine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69446", "l": "alpha-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0061595", "l": "6-deoxy-6-sulfofructose-1-phosphate aldolase activity", "d": ["Catalysis of the reaction 6-deoxy-6-sulfofructose-1-phosphate = 3-sulfolactaldehyde + dihydroxyacetone phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005458", "l": "GDP-mannose transmembrane transporter activity", "d": ["Enables the transfer of a GDP-mannose from one side of a membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51396", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin = CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045133", "l": "2,3-dihydroxybenzoate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxybenzoate + O2 = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23586", "l": "7,8-dihydrofolate + ADP + H(+) + phosphate => 7,8-dihydropteroate + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16050", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole => adenosylcob(III)alamin + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62489", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57909", "l": "ATP + L-glutamyl-tRNA(Gln) => 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001073", "l": "transcription antitermination factor activity, DNA binding", "d": ["Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27686", "l": "ATP + GDP = ADP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37232", "l": "H2O + L-alaninamide => L-alanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685318", "l": "BCDX2 complex formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209109", "l": "Further phosphorylation of ARM by SGG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008263", "l": "pyrimidine-specific mismatch base pair DNA N-glycosylase activity", "d": ["Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37386", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080102", "l": "3-methylthiopropyl glucosinolate S-oxygenase activity", "d": ["Catalysis of the reaction: 3-methylthiopropyl-glucosinolate = 3-methylsulfinylpropyl-glucosinolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49790", "l": "CoA + glycochenodeoxycholate + H(+) => chenodeoxycholoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-507870", "l": "Aquaporins passively transport water out of cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72210", "l": "chloride(out) + 2 hydrogencarbonate(in) <=> chloride(in) + 2 hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19287", "l": "a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol => a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29068", "l": "formate + H(+) + menaquinone-8 => CO2 + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57386", "l": "(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA => (13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667657", "l": "NBEA binds NICD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19346", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate => (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16559", "l": "2-aminomuconate 6-semialdehyde + CO2 => 2-amino-3-carboxymuconate 6-semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209924", "l": "Dopa is decarboxylated to dopamine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341294", "l": "Superoxide reduces cytochrome c (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942302", "l": "MMP13 cleaves OPTC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29107", "l": "H(+) + NADH + ubiquinone-8 = NAD(+) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64950", "l": "dCDP + H(+) + phosphate => dCTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2545253", "l": "Deacetylation of cohesin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41433", "l": "3-methyl-L-tyrosine + H2O2 => 5-hydroxy-3-methyl-L-tyrosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47176", "l": "(2R)-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14757", "l": "2 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone = 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389849", "l": "28S subunit:MTIF3 binds MTIF2:GTP, mRNA, and formylMet-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46015", "l": "(S)-malate + a quinone <=> a quinol + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14218", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] => [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27742", "l": "2'-deoxyadenosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848873", "l": "PTK6 phosphorylates ARAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120301", "l": "histone lactyltransferase activity", "d": ["Catalysis of the reaction: (L-lysyl-[histone] + lactoyl-CoA = CoA + H+ + N(6)-lactoyl-L-lysyl-[histone]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56599", "l": "(1S,4S)-bornane-2,5-dione + FMNH2 + O2 <=> (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43056", "l": "5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH = 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)", "d": []}, {"i": "EC:2.3.1.239", "l": "\"10-deoxymethynolide syntase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209134", "l": "Phosphorylation of ARM by CKIalpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23854", "l": "cis,cis-muconate + 2 H(+) => catechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430158", "l": "p-SLP-76 binds VAV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62372", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559464", "l": "TLR6/2 ligand associates with CD14 and CD36 within lipid rafts (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252072", "l": "AZGP1 binds PIP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16073", "l": "2,2-dialkylglycine + H(+) + pyruvate = CO2 + dialkyl ketone + L-alanine", "d": []}, {"i": "EC:4.1.1.64", "l": "\"2,2-dialkylglycine decarboxylase (pyruvate)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786621", "l": "TRMT10A methylates guanosine-9 in tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21883", "l": "2 H(+) + O2 + oxalate <=> 2 CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22718", "l": "(24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66634", "l": "H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP => L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374919", "l": "Noradrenaline clearance from the synaptic cleft (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0070004", "l": "cysteine-type exopeptidase activity", "d": ["Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54004", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32600", "l": "7-hydroxy-4-isopropenyl-7-methyloxepan-2-one => 3-isopropenyl-6-oxoheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5213466", "l": "RIPK3 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174121", "l": "Association of Securin with Cdc20:APC/C complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015575", "l": "mannitol transmembrane transporter activity", "d": ["Enables the transfer of mannitol from one side of a membrane to the other. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018826", "l": "RHOT2 hydrolyzes GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10035", "l": "[protein]-C-terminal-L-glutamine + H2O <=> [protein]-C-terminal-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.9", "l": "\"Xaa-Pro dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69255", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate <=> 2-(thiiran-2-yl)acetonitrile + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65916", "l": "L-kynurenine + pyruvate = H2O + kynurenate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990882", "l": "CDK1 phosphorylates NUP98 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65265", "l": "3-hydroxypentacecilide A + A => AH2 + chrodrimanin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67308", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209891", "l": "Dopamine is oxidised to noradrenaline (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37924", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28656", "l": "glutathione S,S-dioxide + H2O => glutathione + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034782", "l": "dimethylmalonate decarboxylase activity", "d": ["Catalysis of the reaction: dimethylmalonate + H+ = isobutyrate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74521", "l": "beta-D-Gal-(1<->1')-Cer + H(+) + sulfate => 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14161", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)", "d": []}, {"i": "EC:1.13.11.53", "l": "\"acireductone dioxygenase (Ni(2+)-requiring)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.60", "l": "\"marinolic acid--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196017", "l": "Dynamin is recruited to the gap junction plaque (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67154", "l": "L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein] => L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47052", "l": "(2E,6E)-farnesyl diphosphate = alpha-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71905", "l": "H(+) + N(2)-(ADP-D-ribosyl)-guanine + nicotinamide => guanine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008054", "l": "IL1F10 binds IL1RAPL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10908", "l": "3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25417", "l": "AH2 + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31970", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75129", "l": "codeinone => neopinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68738", "l": "ganoderate Jc + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ganoderate TR + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19733", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) = bacteriochlorophyllide a + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47981", "l": "dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74823", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13603", "l": "4-oxo-L-proline + H(+) + NADH => cis-4-hydroxy-L-proline + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696131", "l": "AOC1 deaminates Hist (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71688", "l": "glycyl-L-aspartate(out) + 2 H(+)(out) => glycyl-L-aspartate(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12469", "l": "avenacoside A + H2O => 26-desgluco-avenacoside A + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40315", "l": "glutaryl-CoA + O2 = (2E)-glutaconyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008564", "l": "protein-exporting ATPase activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25935", "l": "4-methylquinoline + A + H2O <=> 4-methylquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40394", "l": "1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA <=> 1-O-alkyl-2,3-diacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3787997", "l": "Laminin-332 binds collagen type VII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36893", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047811", "l": "D-alanine gamma-glutamyltransferase activity", "d": ["Catalysis of the reaction: D-alanine + L-glutamine = gamma-L-glutamyl-D-alanine + NH4."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034912", "l": "phthalate 3,4-cis-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: phthalate 3,4-cis-dihydrodiol + NAD+ = 3,4-dihydroxyphthalate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39847", "l": "a 2-acylglycerol + ATP = a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43572", "l": "A + D-arginine + H2O = 5-guanidino-2-oxopentanoate + AH2 + NH4(+)", "d": []}, {"i": "EC:1.4.99.6", "l": "\"D-arginine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29619", "l": "alpha-maltotetraose + beta-maltose = alpha-maltopentaose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158849", "l": "Phenol can form a sulfate conjugate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75080", "l": "Formation of AT-AC A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56857", "l": "A + an aldehyde + H2O => a carboxylate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.8", "l": "\"capsanthin/capsorubin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54553", "l": "1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655170", "l": "RCHY1 monoubiquitinates POLH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437995", "l": "Activated JNK migrates to the nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39750", "l": "cholesterol(in) <=> cholesterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40819", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26255", "l": "2 H2O + isopimara-7,15-dienal + NADP(+) => H(+) + isopimara-7,15-dienol + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937989", "l": "RUNX1 binds PRC1 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989754", "l": "Expression of APOA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18412", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52769", "l": "2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O => 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047374", "l": "methylumbelliferyl-acetate deacetylase activity", "d": ["Catalysis of the reaction: 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72376", "l": "hydrogencarbonate(out) + iodide(in) => hydrogencarbonate(in) + iodide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40192", "l": "(3R)-hydroxyoctanoyl-CoA + NAD(+) => 3-oxooctanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13838", "l": "cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) => 4,5-dihydroxyphthalate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47636", "l": "H2O + L-arginine + NADP(+) = 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31806", "l": "H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose <=> 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45591", "l": "a long-chain fatty acid + ATP + holo-[ACP] <=> a long-chain fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65927", "l": "2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine <=> 2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57573", "l": "7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59152", "l": "ATP + CoA + pseudomonate C = AMP + diphosphate + pseudomonoyl-CoA C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858346", "l": "AMHR2 binds AMH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15961", "l": "4-hydroxymandelonitrile + UDP-alpha-D-glucose = H(+) + taxiphyllin + UDP", "d": []}, {"i": "EC:2.4.1.178", "l": "\"hydroxymandelonitrile glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67324", "l": "acetyl-CoA + ATP + 11 H(+) + L-serine + 7 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine = (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2562564", "l": "Caspase-8 processing within TLR4 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047726", "l": "iron-cytochrome-c reductase activity", "d": ["Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940959", "l": "Neurolysin degrades neurotensin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951500", "l": "Dissociation of CANX from nonameric complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59529", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein] => CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396007", "l": "IRF3 is phosphorylated by TBK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418925", "l": "ADORA2A,B bind Ade-Rib (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52566", "l": "3-dehydro-L-erythronate => 2-dehydro-L-erythronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848250", "l": "ACBD6 binds LCFA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45671", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592297", "l": "Full activation of MMP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793444", "l": "ITCH polyubiquitinates MLKL at K50 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18591", "l": "[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate => [glutamine synthetase]-L-tyrosine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48387", "l": "a 2,3-saturated fatty acid + H2O2 <=> a 3-hydroxy fatty acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17741", "l": "NAD(+) + shikimate = 3-dehydroshikimate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157145", "l": "NOTCH3 binds DLL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2562526", "l": "PLK1 phosphorylates OPTN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018785", "l": "RHOBTB2 binds GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785607", "l": "FANCM binds FAAP24 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72663", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-phenylalanyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37678", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031865", "l": "EP2 subtype prostaglandin E2 receptor binding", "d": ["Binding to an EP2 subtype prostaglandin E2 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29694", "l": "alpha-maltotetraose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48850", "l": "13-hydroperoxy-(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64876", "l": "H2O + UDP = H(+) + phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63933", "l": "abscisate(in) + ATP + H2O => abscisate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25192", "l": "chloroacetate + H2O <=> chloride + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16218", "l": "H2O + L-arabinono-1,4-lactone => H(+) + L-arabinonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803425", "l": "TP53 binds ZNF385A gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2247513", "l": "STAB1:ligand is endocytosed (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60255", "l": "(S)-methylmalonyl-CoA + NADP(+) <=> acryloyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203977", "l": "SAR1 Activation And Membrane Binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22024", "l": "H2O + NAD(+) + trimethylamine = 2 H(+) + NADH + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592236", "l": "NRF1:p-PPARGC1A, NRF2 bind the TFB1M promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76033", "l": "3-O-demethylthebaine + CO2 + formaldehyde + succinate => 2-oxoglutarate + O2 + thebaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18833", "l": "4-formylbenzenesulfonate + H2O + NAD(+) = 4-sulfobenzoate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.62", "l": "\"4-formylbenzenesulfonate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34278", "l": "2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine <=> 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696131", "l": "AOC1 deaminates Hist (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47913", "l": "6-deoxy-6-sulfo-D-gluconate => 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48491", "l": "all-trans-retinol--[retinol-binding protein] + NAD(+) <=> all-trans-retinal--[retinol-binding protein] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168848", "l": "tBID binds to inactive BAK protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15839", "l": "N-methyl-L-glutamate + NH4(+) => L-glutamate + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42260", "l": "H(+) + heptanoyl-CoA + malonyl-[ACP] = 3-oxononanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033982", "l": "3-dehydro-L-gulonate-6-phosphate decarboxylase activity", "d": ["Catalysis of the reaction: 3-dehydro-L-gulonate 6-phosphate + H+ = L-xylulose 5-phosphate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56743", "l": "globoside Gb3Cer + UDP-alpha-D-galactose <=> GalGb3Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804762", "l": "TP53 forms homotetramers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.426153789046865", "identifiers": [{"i": "GO:0015144", "l": "carbohydrate transmembrane transporter activity", "d": ["Enables the transfer of carbohydrate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001042", "l": "RNA polymerase I core binding", "d": ["Binding to a RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35595", "l": "benzene-1,2,4-triol + O2 = 2 H(+) + maleylacetate", "d": []}, {"i": "EC:1.13.11.37", "l": "\"hydroxyquinol 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951644", "l": "Release of mature NEDD8 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9706837", "l": "AR binds AR antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692738", "l": "HRH2 binds HRH2 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23257", "l": "adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine => adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690669", "l": "CD22 binds itself to form homo-oligomers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75894", "l": "holothin + pseudomonoyl-CoA C <=> CoA + pseudomonic acid C--holothin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018572", "l": "EGFR phosphorylates NOTCH3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12736", "l": "CO2 + diphosphate + nicotinate beta-D-ribonucleotide <=> 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669863", "l": "Masitinib-resistant KIT mutants do not bind masitinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24625", "l": "ATP + L-threonine + tRNA(Thr) => AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70190", "l": "alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose <=> cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34008", "l": "7-dehydrodesmosterol + S-adenosyl-L-methionine => 5-dehydroepisterol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45623", "l": "H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40536", "l": "4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59692", "l": "D-cellotriono-1,5-lactone + H2O = D-cellotrionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34102", "l": "carboxynorspermidine + H(+) <=> CO2 + norspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734687", "l": "ORC6 is phosphorylated on T195 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9705584", "l": "HMGCR dimer binds statins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60302", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851866", "l": "MET binds RANBP10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794475", "l": "Cipro:ALB dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015364", "l": "dicarboxylate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + inorganic phosphate(in) = dicarboxylate(in) + inorganic phosphate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14054", "l": "D-arabinose 5-phosphate + H2O + phosphoenolpyruvate => 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74601", "l": "AMP(in) + UDP-alpha-D-galactose(out) => AMP(out) + UDP-alpha-D-galactose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33127", "l": "H2O + salicin-6-phosphate = beta-D-glucose 6-phosphate + salicyl alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36108", "l": "gibberellin A4 + S-adenosyl-L-methionine => O-methyl gibberellin A4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75304", "l": "NAD(+) => 3'cADPR + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40330", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0043394", "l": "proteoglycan binding", "d": ["Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30301", "l": "a nucleobase within DNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + a methylated nucleobase within DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18631", "l": "ADP + H(+) + NADP(+) => ATP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445079", "l": "Phosphorylation of L1 by ERK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36026", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694441", "l": "CSNK1D phosphorylates SEC23 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814409", "l": "CK2 phosphorylates PDCL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030795", "l": "methyl jasmonate methylesterase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a jasmonate = S-adenosyl-L-homocysteine + a methyljasmonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20026", "l": "gibberellin A3 + UDP-alpha-D-glucose => gibberellin A3 O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009403", "l": "SMURF1 polyubiquitinates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187382", "l": "Degradation of ubiquitinated SMAD3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68488", "l": "(2R)-2-hydroperoxytetradecanoate + H(+) = CO2 + H2O + tridecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9649735", "l": "Intrinsic nucleotide exchange on RAS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58539", "l": "glycine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35488", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51235", "l": "2-glyceryl-prostaglandin H2 <=> 2-glyceryl-prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202111", "l": "AKT1 phosphorylates eNOS (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56978", "l": "4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin] => 4-methylphenol + H2O + 2 oxidized [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0000701", "l": "purine-specific mismatch base pair DNA N-glycosylase activity", "d": ["Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site."]}, {"i": "EC:3.2.2.31", "l": "\"adenine glycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35952", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate => diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061928", "l": "glutathione specific gamma-glutamylcyclotransferase activity", "d": ["Catalysis of the reaction: glutathione = 5-oxoproline + L-cysteinylglycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24589", "l": "ATP + D-arabinose => ADP + D-arabinose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10693", "l": "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 => H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940561", "l": "MMP7 cleaves OPTC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9676254", "l": "Formation of the MLL3 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15958", "l": "D-altronate => 2-dehydro-3-deoxy-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018746", "l": "RHOQ binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726875", "l": "HCNs:cAMP bind SNIs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71783", "l": "MDH2 reduces OA to MAL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38446", "l": "a fatty acyl-CoA + a long chain fatty alcohol <=> a wax ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210439", "l": "glutamate uptake by astrocytes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034846", "l": "naphthyl-2-methylene-succinyl-CoA lyase activity", "d": ["Catalysis of the reaction: naphthyl-2-methylene-succinyl-CoA + H2O = naphthyl-2-hydroxymethyl-succinyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51796", "l": "deoxycohumulone + dimethylallyl diphosphate = colupulone + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47001", "l": "H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008310", "l": "single-stranded DNA 3'-5' DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65486", "l": "CoA + hexyl hexanoate => hexan-1-ol + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16947", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+) => (6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66689", "l": "4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2 => (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23846", "l": "ADP + D-sedoheptulose 7-phosphate + H(+) => ATP + sedoheptulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19025", "l": "H2O + L-aspartate + O2 = H2O2 + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77609", "l": "Binding of APOBEC-1 to form editosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43649", "l": "H(+) + hexadecanoyl-CoA + malonyl-[ACP] => 3-oxooctadecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52488", "l": "O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37103", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35788", "l": "paromamine + UDP-alpha-D-kanosamine => H(+) + kanamycin C + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110211", "l": "NTHL1 glycosylase mediated recognition and binding of thymine glycol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56355", "l": "4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 <=> 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199935", "l": "MSK1 activates CREB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66890", "l": "8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53496", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33417", "l": "[(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+) => bornane-2,6-dione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444572", "l": "Zinc is an agonist of GPR39 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53349", "l": "5,6-dihydrouridine(20a) in tRNA + NAD(+) => H(+) + NADH + uridine(20a) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74193", "l": "2,2-dimethyl-2,3-dihydro-1-benzofuran-7-ol + CO2 + methylamine => carbofuran + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53264", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390886", "l": "HRH4 binds Hist (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372726", "l": "aspartate [mitochondrial matrix] + glutamate [cytosol] <=> aspartate [cytosol] + glutamate [mitochondrial matrix] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73543", "l": "dCDP(out) + UTP(in) = dCDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6796649", "l": "TP53 binds the CCNK gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033837", "l": "anthocyanin 3'-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + an anthocyanin = UDP + an anthocyanin 3'-O-beta-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692880", "l": "HRH3 binds Hist (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000979", "l": "RNA polymerase II core promoter sequence-specific DNA binding", "d": ["Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160050", "l": "xanthine binding", "d": ["Binding to xanthine, a purine base."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2314678", "l": "ASA- acetylates PTGS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964513", "l": "E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59644", "l": "D-xylobiono-1,5-lactone + H2O = D-xylobionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17919", "l": "[Glu(-Cys)](n+1)-Gly + glycine => [Glu(-Cys)](n)-Gly + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41037", "l": "1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52910", "l": "3-dimethylallyl-4-hydroxymandelate + CO2 => 3-dimethylallyl-4-hydroxyphenylpyruvate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50822", "l": "H(+) + NADPH + testosterone => 17beta-hydroxy-5alpha-androstan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75866", "l": "all-trans-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-4-hydroxy-13,14-dihydroretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57094", "l": "A + glutathione + methanethiol => AH2 + S-(methylsulfanyl)glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851888", "l": "MET binds SHC1-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40548", "l": "10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45495", "l": "phycocyanobilin-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9687625", "l": "ATP binds MLKL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16470", "l": "(R)-2-benzylsuccinate + succinyl-CoA => (R)-2-benzylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73720", "l": "3,4-dihydroxybenzoate + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937037", "l": "RUNX1 and GATA1 bind the promoter of the MIR27A gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11091", "l": "H2O + trimetaphosphate <=> 2 H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008512", "l": "sulfate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15308", "l": "betaine aldehyde + H2O + NAD(+) <=> glycine betaine + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6793666", "l": "MDM2 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44430", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66164", "l": "butanoyl-CoA + serotonin = CoA + H(+) + N-butanoylserotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29748", "l": "3-phenylpropanoate(in) => 3-phenylpropanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004937", "l": "alpha1-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4518585", "l": "NLK mRNA translation controlled by miR-92b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70025", "l": "4-hydroxy-L-proline(out) + Na(+)(out) => 4-hydroxy-L-proline(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54636", "l": "(13E)-labda-7,13-dien-15-yl diphosphate = diphosphate + labda-7,13(16),14-triene", "d": []}, {"i": "EC:4.2.3.192", "l": "\"labda-7,13(16),14-triene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102381", "l": "stevioside glucosyltransferase activity (rebaudioside A forming)", "d": ["Catalysis of the reaction: stevioside + UDP-alpha-D-glucose = rebaudioside A + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23701", "l": "5,10-methenyltetrahydrofolate + H2O => (6S)-10-formyltetrahydrofolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16762", "l": "chlorohydroquinone + O2 => 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27521", "l": "H2O + sphing-4-enine 1-phosphate <=> phosphate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080123", "l": "jasmonate-amino synthetase activity", "d": ["Catalysis of the reaction: jasmonate + an amino acid = an amide-linked jasmonyl-amino acid conjugate. The substrates of this reaction include non-standard amino acids, such as ACC (1-aminocyclopropane-1-carboxylate)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201608", "l": "Caspase-mediated cleavage of alpha adducin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52605", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP => 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47552", "l": "glycodeoxycholate + H2O = deoxycholate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873923", "l": "STARD10 binds LPCAT1 and PC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59907", "l": "H2O + NADP(+) + octanal <=> 2 H(+) + NADPH + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42396", "l": "cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.205", "l": "\"tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20054", "l": "NAD(+) + ribitol => D-ribulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696958", "l": "USP44 deubiquitinates CDC20 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69260", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate = (3R)-3-hydroxy-3-(thiiran-2-yl)propanenitrile + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65882", "l": "5alpha-androstan-1,3,17-trione + AH2 => 1-hydroxy-5alpha-androstan-3,17-dione + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22774", "l": "2-dehydro-3-deoxy-L-fuconate + H2O => L-fuconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9691621", "l": "C5 binds C5 inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015519", "l": "D-xylose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-xylose(out) + H+(out) = D-xylose(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004103", "l": "choline kinase activity", "d": ["Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28183", "l": "(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate => (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71754", "l": "2-oxoglutarate(out) + glutarate(in) <=> 2-oxoglutarate(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034807", "l": "4,5-dihydroxybenzo(a)pyrene methyltransferase activity", "d": ["Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + C1 unit = hydroxymethoxybenzo(a)pyrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204863", "l": "Interaction of Tie2 with Ang2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9761474", "l": "AMOT-2 binds CDH11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12529", "l": "N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate => [hyaluronan](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810899", "l": "TGM1 and involucrin bind the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607753", "l": "CARD9 oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802912", "l": "High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140806", "l": "NAD+- protein-aspartate ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-aspartyl-[protein] + NAD+ = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429767", "l": "Passive I- efflux mediated by SMCT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53697", "l": "2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0071913", "l": "citrate secondary active transmembrane transporter activity", "d": ["Enables the transfer of citrate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:1990189", "l": "peptide-serine-alpha-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + N-terminal L-serine in peptide = CoA + N-acetyl-L-serine-peptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25857", "l": "(9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39220", "l": "3-oxooctacosanyol-CoA + H(+) + NADPH => (3R)-hydroxyoctacosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.125", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12202", "l": "CO2 + mugineate + succinate => 2'-deoxymugineate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37296", "l": "ATP + H2O + L-alanyl-L-threonine(out) => ADP + H(+) + L-alanyl-L-threonine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11418", "l": "1,6-bis-O-galloyl-beta-D-glucose + D-glucose => 2 1-O-galloyl-beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102482", "l": "5-deoxy-D-glucuronate isomerase activity", "d": ["Catalysis of the reaction: 5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63284", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734713", "l": "ORC6 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66255", "l": "ATP + CoA + IC-asc-C7 <=> AMP + diphosphate + IC-asc-C7-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64017", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.49", "l": "\"hypodermin C\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173723", "l": "C8 binds C5b:C6:C7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52167", "l": "O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] <=> (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036050", "l": "Defective SGSH does not hydrolyse Heparan sulfate chain(2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36632", "l": "D-ribulose 1,5-bisphosphate + O2 => (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53843", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADP(+) <=> 7,12-dioxo-lithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75547", "l": "2 (3R)-3-isocyanylbutanoyl-[ACP] + ATP + L-lysine + 2 NADPH = (2S)-2,6-bis[(3R)-3-isocyanobutanamido]hexan-1-ol + AMP + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641111", "l": "Parkin transfers Ub to misfolded proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72705", "l": "UDP-alpha-D-galactose(out) + UMP(in) => UDP-alpha-D-galactose(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46267", "l": "an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44200", "l": "12-methyloctadecanoate + ATP + CoA = 12-methyloctadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9656893", "l": "OPN1MW binds 11cRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-877281", "l": "PIAS1 binds p-STAT1 dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038021", "l": "leptin receptor activity", "d": ["Combining with the fat-cell specific hormone leptin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15257", "l": "D-threonine = acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13505", "l": "choline + O2 = betaine aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111970", "l": "PKC phosphorylates GRK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29051", "l": "2 H(+)(in) + H2 + menaquinone-8 = 2 H(+)(out) + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951644", "l": "Release of mature NEDD8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31562", "l": "L-galactose + NAD(+) <=> H(+) + L-galactono-1,4-lactone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.89", "l": "\"Pro-Pro endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042962", "l": "acridine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3785768", "l": "MRN complex binds DNA double strand breaks (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0030745", "l": "dimethylhistidine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha,N-alpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870269", "l": "Gastrin binds to CCK-B receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29624", "l": "alpha-maltopentaose + beta-maltose => alpha-maltohexaose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618486", "l": "miR-26 binds to the 3'UTR of the ABCA1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33997", "l": "5-oxo-L-proline + butirosin B => gamma-L-glutamyl-butirosin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866941", "l": "MID1IP1 binds THRSP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50974", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788623", "l": "p-Y-STATs translocate to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18604", "l": "3,4-dihydroxyphthalate + H(+) <=> 3,4-dihydroxybenzoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29388", "l": "CTP + H2O => CDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30280", "l": "2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] => 3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63906", "l": "H2O + phenguignardate => 2 3-phenylpyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25831", "l": "AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2 <=> A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56826", "l": "A + cyclooctatin + H2O => AH2 + cyclooctat-9-ene-5,7-diol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65622", "l": "CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine => hexadecanoyl-CoA + sphinga-(4E,8E)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177922", "l": "EGFR dimerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50580", "l": "acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19296", "l": "a monoacylglycerol + ATP <=> ADP + H(+) + monoacyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46381", "l": "7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16184", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399913", "l": "atRAL binds to RBP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19183", "l": "a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015417", "l": "ABC-type polyamine transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36389", "l": "6''-O-carbamoylkanamycin A + AMP + H(+) => carbamoyl adenylate + kanamycin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35740", "l": "cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] => 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0036440", "l": "citrate synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788622", "l": "p-Y-STATs dimerize (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68762", "l": "8 AMP + 8 diphosphate + 8 H(+) + PF1022C + 4 S-adenosyl-L-homocysteine => 3 (R)-3-phenyllactate + (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25069", "l": "(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017083", "l": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity", "d": ["Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-D-glucosaminyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.110", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18565", "l": "19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine = 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.3.1.161", "l": "\"lovastatin nonaketide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59402", "l": "D-2-aminohexanoate => L-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77081", "l": "Formation of the CE:GMP intermediate complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48952", "l": "14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64896", "l": "2 H2O + UTP = 2 H(+) + 2 phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70521", "l": "(R)-synephrine + H(+) + S-adenosyl-L-homocysteine => (R)-octopamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74933", "l": "a (3R)-3-isocyanyl-fatty acid + 3 CO2 + 2 H2O + 2 succinate => 2 2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70329", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) + NADH => (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44391", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68242", "l": "L-methionine(out) + Na(+)(out) => L-methionine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508282", "l": "SYK is a substrate for JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004198", "l": "calcium-dependent cysteine-type endopeptidase activity", "d": ["Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222597", "l": "Loaded mycobactin gets imported (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33041", "l": "2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64131", "l": "H2O + N-octadecanoyl-L-phenylalanine <=> L-phenylalanine + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036220", "l": "ITP diphosphatase activity", "d": ["Catalysis of the reaction: ITP + H2O = IMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56154", "l": "(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45677", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373716", "l": "DCC interacting NCK-1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730842", "l": "PI3K associates with phosphorylated GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202111", "l": "AKT1 phosphorylates eNOS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203613", "l": "depalmitoylation of eNOS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77068", "l": "Activation of GT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106370", "l": "protein-L-histidine N-pros-methyltransferase activity", "d": ["Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine."]}, {"i": "RHEA:67076", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine = H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21720", "l": "formamide = H2O + hydrogen cyanide", "d": []}, {"i": "EC:4.2.1.66", "l": "\"cyanide hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73947", "l": "(2E)-geranyl diphosphate = (4E,6E)-allo-ocimene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20044", "l": "3-oxopropanoate + H2O + NADP(+) <=> 2 H(+) + malonate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75763", "l": "(9E,11E)-octadecadienoate + H2O = 10-hydroxy-(11E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65936", "l": "beta-D-mannose = beta-D-glucose", "d": []}, {"i": "EC:5.1.3.44", "l": "\"mannose 2-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3245898", "l": "TCN1 binds correnoids in the circulation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050270", "l": "S-adenosylhomocysteine deaminase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O + H+ = S-inosyl-L-homocysteine + NH4."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050084", "l": "mannitol-1-phosphatase activity", "d": ["Catalysis of the reaction: D-mannitol 1-phosphate + H2O = D-mannitol + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37661", "l": "CoA + O-methyl anthranilate => anthraniloyl-CoA + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047659", "l": "alpha-santonin 1,2-reductase activity", "d": ["Catalysis of the reaction: 1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42350", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24943", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) = (4S)-4-hydroxy-L-glutamate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65122", "l": "L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine => H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19310", "l": "2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O => (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35716", "l": "(2S,3S)-versiconal hemiacetal acetate + H2O => (2S-3S)-versiconal hemiacetal + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49032", "l": "(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] = 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.132", "l": "\"(-)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12180", "l": "anthranilate + S-adenosyl-L-methionine = H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.111", "l": "\"anthranilate N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761846", "l": "NFE2L2-dependent PGD gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380272", "l": "Plk1-mediated phosphorylation of Nlp (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12101", "l": "1,5-anhydro-D-fructose => H2O + microthecin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17575", "l": "H(+) + macrocin + S-adenosyl-L-homocysteine => demethylmacrocin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67222", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + H(+) + NADH => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11956", "l": "cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047257", "l": "diglucosyl diacylglycerol synthase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-D-glucose = UDP + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1,2)-O-alpha-D-glucopyranosyl)-sn-glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64025", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine) => H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018731", "l": "1-oxa-2-oxocycloheptane lactonase activity", "d": ["Catalysis of the reaction: 1-oxa-2-oxocycloheptane + H2O = 6-hydroxyhexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668365", "l": "FVIIIa variant:FIXa does not convert FX to the active FXa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202216", "l": "Phosphorylation of SLP-76 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52317", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048270", "l": "methionine adenosyltransferase regulator activity", "d": ["Binds to and modulates the activity of methionine adenosyltransferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10781", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) => 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64084", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) = 2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68581", "l": "ATP + H2O + L-kynurenine(out) => ADP + H(+) + L-kynurenine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651782", "l": "FEN1 bound to POLB cleaves displaced DNA strand (flap) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19913", "l": "a (3R)-hydroxyacyl-[ACP] + NAD(+) = a 3-oxoacyl-[ACP] + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.212", "l": "\"3-oxoacyl-[acyl-carrier-protein] reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22338", "l": "L-methionine + N,N-dimethylglycine => glycine betaine + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68467", "l": "2-butyloctyl sulfate + H2O <=> 2-butyloctan-1-ol + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050536", "l": "(S)-N-acetyl-1-phenylethylamine hydrolase activity", "d": ["Catalysis of the reaction: N-acetylphenylethylamine + H2O = acetate + phenylethylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30502", "l": "H(+) + N,N-dihydroxy-L-valine <=> (E)-2-methylpropanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247840", "l": "WLS binds WNT ligands in the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16822", "l": "6-phospho-D-gluconate + NAD(+) => 6-phospho-2-dehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37634", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213201", "l": "Formation of collagen fibres (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71736", "l": "formyl-CoA + succinate => formate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63408", "l": "6-chloropyridine-2,3,5-triol + FADH2 + O2 = 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34601", "l": "3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH => 15-methylhexadecasphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65563", "l": "2-oxoglutarate + L-kynurenine <=> H2O + kynurenate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31464", "l": "crocetin + UDP-alpha-D-glucose => beta-D-glucosyl crocetin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43523", "l": "2-carboxy-5-(dihydroxymethyl)furan + O2 <=> 2,5-dicarboxyfuran + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58894", "l": "adenosine 3',5'-bisphosphate + H(+) + omega-sulfo-beta-dihydromenaquinone-9 => 3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46812", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003960", "l": "NADPH:quinone reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429157", "l": "ABCC4 accumulation of dense granule contents (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48325", "l": "ganglioside GD1b + GDP-beta-L-fucose => ganglioside Fuc-GD1b + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75766", "l": "(9E,11E)-octadecadienoate + H2O <=> 10-hydroxy-(11E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69870", "l": "a uridine in RNA + S-adenosyl-L-methionine <=> a 5-methyluridine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38126", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602004", "l": "Defective CYP24A1 does not 24-hydroxylate CALTOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57665", "l": "(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] => alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0042162", "l": "telomeric DNA binding", "d": ["Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15881", "l": "ATP + L-seryl-[Fas-activated protein] = ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21147", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40232", "l": "(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23514", "l": "beta-D-glucose 1-phosphate + D-glucose => alpha,alpha-trehalose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48829", "l": "H(+) + NADPH + O2 + resorcinol => benzene-1,2,4-triol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68365", "l": "4-CDP-2-C-methyl-D-erythritol => 2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64600", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3204303", "l": "MRE11 binds cytosolic DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68915", "l": "ATP + H(+) + NADPH + propanoate <=> AMP + diphosphate + NADP(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74140", "l": "petunidin + UDP-alpha-D-glucose => petunidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197958", "l": "FPGS-2 transforms THF to THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57562", "l": "7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => (+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28032", "l": "[thioredoxin]-dithiol + GDP => [thioredoxin]-disulfide + dGDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23028", "l": "malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein] = acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein]", "d": []}, {"i": "EC:2.1.3.10", "l": "\"malonyl-S-ACP:biotin-protein carboxyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61515", "l": "malvidin + UDP-alpha-D-glucose <=> malvidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141439", "l": "Release of activated MAD2 from kinetochores (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27709", "l": "ATP + D-alanine + D-serine <=> ADP + D-alanyl-D-serine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56779", "l": "(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11366", "l": "AMP + 2 H(+) + phosphate + phosphoenolpyruvate => ATP + H2O + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31452", "l": "2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) => a cardiolipin + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71010", "l": "L-phenylalanine(out) + L-tryptophan(in) <=> L-phenylalanine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011543", "l": "DCA binds PDK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130504", "l": "Cleavage of lip22 to lip10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61758", "l": "H(+) + rebaudioside A + UDP => stevioside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50663", "l": "3-(3-methylsulfanyl)propylmalate <=> 2-(2-methylsulfanyl)propylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696547", "l": "STAMBPL1 is a deubiquitinase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29971", "l": "2'-deoxyinosine(in) + H(+)(in) = 2'-deoxyinosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0001099", "l": "basal RNA polymerase II transcription machinery binding", "d": ["Binding to a component of the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50308", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014449", "l": "RHOG binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0042803", "l": "protein homodimerization activity", "d": ["Binding to an identical protein to form a homodimer."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75359", "l": "L-mimosine = 2-aminoprop-2-enoate + 3-hydroxy-4H-pyrid-4-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46371", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68800", "l": "H2O + nigerose = alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29787", "l": "ATP + glutathione(in) + H2O = ADP + glutathione(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9761421", "l": "CDH11 associates with catenins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202731", "l": "JAM3 dimerises (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55819", "l": "a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976726", "l": "NOTCH2 coactivator complex binds HES5 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30602", "l": "15-cis-phytoene + 3 A <=> 3 AH2 + all-trans-neurosporene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34313", "l": "2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite => 4-nitrocatechol + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61335", "l": "ATP + H2O + indoxyl sulfate(in) <=> ADP + H(+) + indoxyl sulfate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.37", "l": "\"malate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.48", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655830", "l": "Expression of Acetyl CoA Carboxylase 2 (ACACB, ACC2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38518", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450533", "l": "PKCdelta phosphorylates HuR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0000182", "l": "rDNA binding", "d": ["Binding to a DNA sequence encoding a ribosomal RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3791319", "l": "NID1 degradation by MMP19 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177479", "l": "Axonal transport of NGF:Trk complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617828", "l": "TRIP11:IFT20 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32784", "l": "ATP + glycine betaine(out) + H2O => ADP + glycine betaine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63547", "l": "H2O + kinetensin <=> kinetensin-(1-8) + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5627775", "l": "Autophosphorylation of PAK1,2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936068", "l": "H19 is cleaved to produce miR-675 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798257", "l": "PTPRS binds NTRK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28506", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP = 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69438", "l": "7beta-hydroxypregnenolone + NADP(+) => 7-oxopregnenolone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13485", "l": "2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = 3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.75", "l": "\"cysteine-conjugate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44351", "l": "ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide B + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854222", "l": "TBC1D3 associates with RAB5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45121", "l": "(4R)-ipsdienol + NAD(+) => H(+) + ipsdienone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13045", "l": "ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396370", "l": "VTN binds collagens II, III and V (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16521", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22683", "l": "dCTP + H(+) + H2O <=> dUTP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63646", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+) => GDP-beta-L-fucose + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22281", "l": "O-demethylpuromycin + S-adenosyl-L-methionine => H(+) + puromycin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009541", "l": "ESR1 binds to TFF1 gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758868", "l": "Unknown efflux pump transports glucuronidated PRED metabolite (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15116", "l": "5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O <=> 5alpha-cholestane-3beta,5,6beta-triol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693783", "l": "NAALADases hydrolyse NAAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42232", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4411373", "l": "NLK translocates to nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033448", "l": "AGG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AGG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730841", "l": "Phosphorylation and activation of VAV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74814", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32478", "l": "glycine + 3 S-adenosyl-L-methionine <=> glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451033", "l": "(S)-Malate <=> Fumarate + H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29647", "l": "alpha-maltopentaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltotetraose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0016727", "l": "oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule."]}, {"i": "EC:1.17.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59446", "l": "1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2 => 1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661425", "l": "BIL:ALB dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12473", "l": "H2O + N-ethylglycine + O2 => ethylamine + glyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62695", "l": "2 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + O2 <=> 2 H(+) + 2 H2O + 2 tellimagrandin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34257", "l": "(R)-tetraprenyl-beta-curcumene + H2O => sporulenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14911", "l": "aldehydo-D-glucuronate + H(+) + NADPH => L-gulonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791069", "l": "Expression of ACADVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867041", "l": "EGFR phosphorylates EPS15 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467794", "l": "Resolution of sister chromatids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9604328", "l": "AKT1 phosphorylates NOTCH4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205118", "l": "TRAF6 polyubiquitinates NRIF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69206", "l": "ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + phosphate => ATP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103082", "l": "2-(4'-methylthio)butylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + acetyl-CoA + H2O <=> H+ + 2-(4'-methylthio)butylmalate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210920", "l": "NEUROG3-dependent synthesis of NEUROD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199203", "l": "PANK1/3/4 phosphorylate PanK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57983", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose <=> (20S)-ginsenoside F1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62825", "l": "beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose => beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42152", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647980", "l": "mature RAS proteins translocate to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008241", "l": "peptidyl-dipeptidase activity", "d": ["Catalysis of the release of C-terminal dipeptides from a polypeptide chain."]}, {"i": "EC:3.4.15.-", "l": "\"Peptidyl-dipeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928641", "l": "PAK binds RAC and bPIX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44138", "l": "CoA + hexadecanyl dodecanoate => dodecanoyl-CoA + hexadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26058", "l": "GTP + H(+) + valienol 1-phosphate <=> diphosphate + GDP-valienol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63101", "l": "H(+) + ilicicolin C + NADPH + O2 => ascochlorin + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31348", "l": "(+)-abscisic acid D-glucopyranosyl ester + H2O => 2-cis-(+)-abscisate + beta-D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24568", "l": "a 6-phospho-beta-D-galactoside + H2O = an alcohol + D-galactose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507870", "l": "Aquaporins passively transport water out of cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70343", "l": "chloride + L-tyrosine + NADP(+) = 3-chloro-L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37606", "l": "(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-532549", "l": "MPI isomerises Fru6P to Man6P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20966", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate => 2-oxoglutarate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40416", "l": "H2O + pristanoyl-CoA => 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047021", "l": "15-hydroxyprostaglandin dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534359", "l": "CatSper Channel Mediated Calcium Transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41165", "l": "1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-amino-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390641", "l": "ADRA1A,B,D bind ADR,NAd (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35250", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(in) + ATP + H2O <=> ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68015", "l": "H2O + hypoxanthine + O2 <=> H2O2 + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170846", "l": "TGFBR2 recruits TGFBR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68412", "l": "H2O + L-glutamate 5-semialdehyde + NADP(+) = 2 H(+) + L-glutamate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159771", "l": "Furin cleaves pro-protein C to protein C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52113", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45918", "l": "4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682967", "l": "WHSC1 binds DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60481", "l": "2 UTP => c-di-UMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797993", "l": "TP53 and CREBBP bind BNIP3L gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52905", "l": "15,17(3)-seco-F430-17(3)-acid + ATP => ADP + coenzyme F430 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375140", "l": "CDO binds promyogenic cadherins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944223", "l": "Association of procollagen type V (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75783", "l": "ADP(in) = ADP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9656244", "l": "DRD2 binds DA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28945", "l": "glycine betaine(out) => glycine betaine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944232", "l": "Association of procollagen type XII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1370505", "l": "PRLR is phosphorylated at Ser-349 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10655", "l": "a long-chain fatty aldehyde + H2O + NAD(+) <=> a long-chain fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63205", "l": "H2O + octadecanoyl-[ACP] => H(+) + holo-[ACP] + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34434", "l": "(+)-secoisolariciresinol + NADP(+) <=> (-)-lariciresinol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66839", "l": "4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase] <=> asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41661", "l": "dihydrosanguinarine + NAD(+) => NADH + sanguinarine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22637", "l": "dCTP + H2O => dCMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047064", "l": "sulochrin oxidase [(+)-bisdechlorogeodin-forming] activity", "d": ["Catalysis of the reaction: O2 + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57160", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2 = (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120136", "l": "dUMP kinase activity", "d": ["Catalysis of the reaction: ATP + dUMP = ADP + dUDP."]}, {"i": "RHEA:30655", "l": "ATP + dUMP = ADP + dUDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28681", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-8 => 3-demethylubiquinol-8 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13345", "l": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]", "d": []}, {"i": "EC:2.5.1.58", "l": "\"protein farnesyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31414", "l": "a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32536", "l": "(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O => 4-hydroxy-2-oxohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72172", "l": "2 Na(+)(out) + taurohyocholate(out) => 2 Na(+)(in) + taurohyocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2089971", "l": "Secretion of collagens (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16977", "l": "acetoacetate + coenzyme M + NADP(+) = 2-oxopropyl-coenzyme M + CO2 + NADPH", "d": []}, {"i": "EC:1.8.1.5", "l": "\"2-oxopropyl-CoM reductase (carboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016979", "l": "lipoate-protein ligase activity", "d": ["Catalysis of the lipoylation of a protein in two steps: ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate (overall reaction): (1) ATP + (R)-lipoate = lipoyl-AMP + diphosphate; (2) lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22194", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => (6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43085", "l": "cytidine(34) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080047", "l": "GDP-L-galactose phosphorylase activity", "d": ["Catalysis of the reaction: GDP-beta-L-galactose + phosphate = beta-L-galactose-1-phosphate + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58850", "l": "(6E)-8-hydroxygeranial + H(+) + NADH => (6E)-8-hydroxygeraniol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51027", "l": "H(+) + NADH + O2 + toluene-4-sulfonate <=> 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44411", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990244", "l": "histone H2AT120 kinase activity", "d": ["Catalysis of the reaction: histone H2A-threonine (position 120) + ATP = histone H2A-phosphothreonine (position 120) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 120 of histone H2A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928620", "l": "PAK1 autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60160", "l": "ATP + H2O + vincristine(in) = ADP + H(+) + phosphate + vincristine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.45", "l": "\"2-dehydro-3-deoxygluconokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043337", "l": "cardiolipin synthase (CMP-forming)", "d": ["Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.338", "l": "\"desmethylxanthohumol 6'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426153", "l": "SREBP1A,1C binds the ACACB promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66723", "l": "ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in) <=> ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9613497", "l": "Unwinding DNA for the nascent transcript (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034824", "l": "citronellyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: citronellyl-CoA + NAD+ = cis-geranyl-CoA + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190256", "l": "FGFR1c binds to FGF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73446", "l": "2-oxoglutarate + gardenin B + O2 <=> CO2 + formaldehyde + H(+) + nevadensin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015128", "l": "gluconate transmembrane transporter activity", "d": ["Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015548", "l": "organomercurial transmembrane transporter activity", "d": ["Enables the transfer of organomercurial compounds from one side of a membrane to the other. Organomercurial substances are any organic compound containing a mercury atom."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5658438", "l": "SPRED dimer binds NF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16716", "l": "H2O + S-succinylglutathione <=> glutathione + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684836", "l": "CLEC1B dimer binds PDPN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29485", "l": "(+)-beta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120204", "l": "methylcytosine to 5-glyceryl-methylcytosine dioxygenase activity", "d": ["Catalysis of the reaction: methylcytosine + L-ascorbate + O2 = 5-glyceryl-methylcytosine + glyoxylate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021952", "l": "RBFOX1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43312", "l": "ATP + N-(hexanoyl)sphing-4-enine = ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68561", "l": "arsenate + D-glyceraldehyde 3-phosphate + NAD(+) => 1-arsono-3-phospho-D-glycerate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634430", "l": "IL6R gene expression is enhanced by CEBPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11512", "l": "salicyl alcohol + UDP-alpha-D-glucose = H(+) + salicin + UDP", "d": []}, {"i": "EC:2.4.1.172", "l": "\"salicyl-alcohol beta-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106361", "l": "protein-arginine rhamnosyltransferase activity", "d": ["Catalysis of the reaction: dTDP-beta-L-rhamnose + L-arginyl-[protein] = dTDP + H+ + N(omega)-(L-rhamnosyl)-L-arginyl-[protein]."]}, {"i": "RHEA:66692", "l": "dTDP-beta-L-rhamnose + L-arginyl-[protein] = dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.89", "l": "\"signal peptidase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31508", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114254", "l": "CYCS binds to APAF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211239", "l": "Association of DFF40 with chromatin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12263", "l": "ATP + NADH <=> ADP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015452", "l": "methyl transfer-driven active transmembrane transporter activity", "d": ["Primary active transport of a solute across a membrane driven by a methyl transfer reaction. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source."]}, {"i": "TCDB:3.C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45278", "l": "12-hydroxy-(9E)-octadecenoate + phosphate => 12-phosphooxy-(9E)-octadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617735", "l": "TXN disrupts FOXO4 complex with EP300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008770", "l": "[acyl-carrier-protein] phosphodiesterase activity", "d": ["Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62023", "l": "H2O + sitosteryl 3-beta-D-glucoside <=> D-glucose + sitosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13685", "l": "lathosterol + NADP(+) = 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65883", "l": "1-hydroxy-5alpha-androstan-3,17-dione + A <=> 5alpha-androstan-1,3,17-trione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426209", "l": "DAG activation of TRPC channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35757", "l": "H(+) + NADH + UDP-3-oxo-alpha-D-glucose => NAD(+) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696482", "l": "CTF1 binds LIFR:JAKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69496", "l": "decan-1-ol + O2 = decanal + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28209", "l": "2'-deoxyuridine + ATP <=> ADP + dUMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357828", "l": "RIPK1 is cleaved by CASP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951966", "l": "EP300 acetylates RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70581", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009817", "l": "Acitretin binds to RAR:RXR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679239", "l": "ULK complex translocates to the ER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13875", "l": "abieta-7,13-diene + diphosphate => (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.43", "l": "\"atroxase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35655", "l": "2 ATP = 3',3'-c-di-AMP + 2 diphosphate", "d": []}, {"i": "EC:2.7.7.85", "l": "\"diadenylate cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47802", "l": "an aromatic oxo-acid + L-methionine => 4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54592", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11715", "l": "3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63759", "l": "flavokermesate + UDP-alpha-D-glucose <=> flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33069", "l": "(4R)-hydroxysphinganine + phosphate => (4R)-hydroxysphinganine 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73771", "l": "O2 + preechinulin + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + neoechinulin A + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112271", "l": "The receptor:G-protein complex dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5579081", "l": "Defective ACY1 does not hydrolyse mercapturic acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39090", "l": "decanedioyl-CoA + O2 <=> (2E)-decenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59516", "l": "acetylsalicylate + L-lysyl-[protein] = H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19730", "l": "acetoacetate + H(+) => acetone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48030", "l": "acetate + diacetylglycerol + H(+) => H2O + triacetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10037", "l": "4-hydroxy-3-methoxy-benzenemethanol + O2 => H2O2 + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655269", "l": "Activated FGFR1 mutants bind FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33552", "l": "an N-acylsphinganine + H2O => a fatty acid + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22037", "l": "[phosphate](n) + D-glucose => [phosphate](n-1) + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25457", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + gamma-humulene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74364", "l": "coproporphyrin III(out) => coproporphyrin III(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59055", "l": "D-lysine + H(+) <=> cadaverine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28987", "l": "H(+)(in) + N-acetylneuraminate(in) = H(+)(out) + N-acetylneuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389862", "l": "Conversion of glyoxylate to oxalate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29422", "l": "H(+)(out) + Na(+)(in) <=> H(+)(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928639", "l": "p-EFNB binds GRB4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32744", "l": "L-homocysteine + O-acetyl-L-serine => acetate + H(+) + L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55840", "l": "calcidiol + UDP-alpha-D-glucuronate = calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32910", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.42903515889401", "identifiers": [{"i": "GO:0140103", "l": "catalytic activity, acting on a glycoprotein", "d": ["Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31179", "l": "(3S)-3-hydroxydodecanoyl-CoA + NAD(+) = 3-oxododecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21423", "l": "NADP(+) + prostaglandin I2 <=> 15-dehydro-prostaglandin I2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2529020", "l": "CK2 phosphorylates condensin I subunits (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46012", "l": "(S)-malate + a quinone = a quinol + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74359", "l": "coproporphyrin I(out) = coproporphyrin I(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.91", "l": "\"cellulose 1,4-beta-cellobiosidase (non-reducing end)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433374", "l": "Processing of SCF isoform 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674550", "l": "p-Y-STAT1,3,5 dimer translocates from the cytosol to the nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013159", "l": "CDC42 GEFs activate CDC42 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976801", "l": "Complement factor I complex formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362427", "l": "Hh-Np binds GPC5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75037", "l": "1-hexadecanoyl-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625693", "l": "TRIM63 gene expression is stimulated by FOXO1 and FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40857", "l": "FADH2 + trans-2-undecenoyl-CoA => FAD + H(+) + undecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111956", "l": "Calmodulin activates Cam-PDE 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13449", "l": "2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67296", "l": "(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 = (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74291", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate = an alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42705", "l": "hercynine + L-cysteine + O2 => H2O + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31947", "l": "ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase] = ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034875", "l": "NTRK3 phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65411", "l": "NAD(+)(in) <=> NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22954", "l": "(2E)-octenedioyl-CoA + H2O2 => O2 + octanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663752", "l": "KCNN2 transports K+ from the cytosol to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65778", "l": "3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47205", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9718020", "l": "PTGFR binds PTGFR agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641134", "l": "SMURF2 binds AXIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64331", "l": "(7Z)-octadecenoyl-CoA + cholesterol <=> cholesteryl (7Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49931", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10578", "l": "CDP-N-methylethanolamine + diphosphate => CTP + H(+) + N-methylethanolamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265456", "l": "NPC1L1 binds ezetimibe (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.59", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58355", "l": "2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47011", "l": "[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide <=> [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71499", "l": "6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = 6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682388", "l": "Autophagosome maturation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68884", "l": "3-hydroxybenzoate + ATP + H(+) + NADPH = 3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981832", "l": "NMUR2 binds neuromedin-S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72185", "l": "mRNA polyadenylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425861", "l": "Activation of Protein Kinase C novel isoforms (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66883", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875431", "l": "LRIG1 undergoes ubiquitination (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851038", "l": "BTN3A1 binds prenylated phosphoantigens (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102831", "l": "stachyose synthase activity", "d": ["Catalysis of the reaction: 2 raffinose <=> stachyose + sucrose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71037", "l": "L-phenylalanine(in) + L-serine(out) => L-phenylalanine(out) + L-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0061798", "l": "GTP 3',8'-cyclase activity", "d": ["Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0048403", "l": "brain-derived neurotrophic factor binding", "d": ["Binding to brain-derived neurotrophic factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1236970", "l": "Proteasomal clevage of exogenous antigen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45904", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine = dTDP + epivancomycin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606839", "l": "Steryl sulfatase hydrolyses sulfate from steroid sulfates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964773", "l": "OXGR1 binds 2OG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60234", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39327", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA = (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010327", "l": "acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + (Z)-3-hexen-1-ol = CoA + (Z)-3-hexen-1-yl acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14157", "l": "H2O + triphosphate = diphosphate + phosphate", "d": []}, {"i": "EC:3.6.1.25", "l": "\"triphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19251", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + glycine => glyoxylate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.341", "l": "\"vanillate/3-O-methylgallate O-demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762345", "l": "PREDN:ALB dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983696", "l": "The Immunoglobulin of the BCR binds antigen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18345", "l": "a cis-3-alkyl-4-alkyloxetan-2-one = a cis-alkene + CO2", "d": []}, {"i": "EC:4.1.1.114", "l": "\"cis-3-alkyl-4-alkyloxetan-2-one decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679775", "l": "COMT binds COMT Inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43384", "l": "ATP + L-arginyl-[protein] = ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]", "d": []}, {"i": "EC:2.7.14.1", "l": "\"protein arginine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-606326", "l": "HJURP:CENPA complex localizes to the centromere (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033251", "l": "cephalosporinase activity", "d": ["Catalysis of the reaction: a cephalosporin + H2O = a substituted beta-amino acid derivative of the cephalosporin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9769235", "l": "MAGED1 binds NPAS4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-166387", "l": "The FA anion diffuses away laterally from UCP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75249", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-prolyl-[protein] => acetyl-CoA + N-terminal L-prolyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75489", "l": "dehydroepiandrosterone 3-sulfate(in) + n H(+)(in) => dehydroepiandrosterone 3-sulfate(out) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59127", "l": "(S)-2,3-diaminopropanoate + ATP + citrate <=> 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198756", "l": "ERK1/2 phosphorylates MSK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56293", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] => 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55076", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) = 3-methylsulfanylpropanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70691", "l": "chloride(out) + glycine(out) + 2 Na(+)(out) = chloride(in) + glycine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018746", "l": "phenanthrene-3,4-epoxide hydrolase activity", "d": ["Catalysis of the reaction: phenanthrene-3,4-oxide + H2O = trans-3,4-dihydrodiolphenanthrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428273", "l": "SPHK1 phosphorylates SPG to S1P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686625", "l": "LAIR1 binds collagen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28169", "l": "5-nitroanthranilate + H(+) + H2O <=> 5-nitrosalicylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8986083", "l": "USP33 deubiquitinates ROBO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050648", "l": "5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding", "d": ["Binding to 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050288", "l": "sorbose dehydrogenase activity", "d": ["Catalysis of the reaction: L-sorbose + A = 5-dehydro-D-fructose + AH(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507869", "l": "Aquaporins passively transport glycerol into cells (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43485", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332359", "l": "Active calmodulin binds CAMK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48023", "l": "globoside Gb3Cer + H2O <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54332", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796617", "l": "MIB2 binds CFLAR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26530", "l": "4-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.120", "l": "\"4-hydroxybutanoyl-CoA dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375384", "l": "Bombesin-like receptors bind bombesin homologues (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35468", "l": "(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839098", "l": "Activated FGFR1 mutants and fusions phosphorylate PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336182", "l": "GPR37 binds prosaptide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853496", "l": "SCF:FBXL7 binds AURKA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693761", "l": "FA2H hydroxylates CERA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004650", "l": "polygalacturonase activity", "d": ["Catalysis of the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0120294", "l": "peptide serotonyltransferase activity", "d": ["Catalysis of the reaction: L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+)."]}, {"i": "RHEA:66552", "l": "L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75677", "l": "(12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35535", "l": "cyclo(L-phenylalanyl-L-leucyl) + O2 = cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042292", "l": "URM1 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63785", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34942", "l": "H2O + menaquinone-8 + selenite <=> menaquinol-8 + selenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801666", "l": "PLK2 phosphorylates CENPJ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74675", "l": "AH2 + archaeol + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaeol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69498", "l": "decanal + H2O2 => decan-1-ol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102462", "l": "quercetin 3-sophoroside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose <=> quercetin 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-996727", "l": "REST recruits the BHC complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429101", "l": "HMIT co-transports myo-inositol with a proton (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35815", "l": "4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74166", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419645", "l": "Dimerization of LIMK1 by Hsp90 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806629", "l": "Formation of tonofilament bundles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706308", "l": "Active FLT3 binds to GRB10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389862", "l": "Conversion of glyoxylate to oxalate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909724", "l": "Recruitment of IFNAR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052692", "l": "raffinose alpha-galactosidase activity", "d": ["Catalysis of the reaction: raffinose + H2O = alpha-D-galactose + sucrose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54965", "l": "hexadecanoyl-[ACP] + phosphate => hexadecanoyl phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976723", "l": "Serum amyloid P-component forms homopentamers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17457", "l": "[sulfur-carrier protein]-L-cysteine + L-cysteine = [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848596", "l": "PTK6 binds PXN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.183", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112434", "l": "Formation of DSIF complex  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20330", "l": "ATP + L-seryl-[low-density-lipoprotein receptor] => ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26298", "l": "1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39081", "l": "3-oxododecanedioyl-CoA + H(+) + NADH => (3S)-hydroxydodecanedioyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21891", "l": "(1S,2S)-OPC-8 + NADP(+) <=> (9S,13S,15Z)-12-oxophyto-10-15-dienoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0034639", "l": "L-amino acid efflux transmembrane transporter activity", "d": ["Enables the transfer of an L-amino acid from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654159", "l": "Activated FGFR2 binds PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170159", "l": "Translocation of Cdc25 to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46862", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP => 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31709", "l": "2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al => 2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803890", "l": "SFN dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53410", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73611", "l": "CTP(out) + dCDP(in) = CTP(in) + dCDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61120", "l": "kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043398", "l": "HLH domain binding", "d": ["Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640167", "l": "RRAGA,B exchanges GDP for GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14993", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)", "d": []}, {"i": "EC:2.3.1.85", "l": "\"fatty-acid synthase system\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043212", "l": "carbohydrate-exporting ABC transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(in) -> ADP + phosphate + carbohydrate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31432", "l": "(2E,6E)-farnesyl diphosphate => (-)-beta-santalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341294", "l": "Superoxide reduces cytochrome c (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56908", "l": "(7S)-O-acetylsalutaridinol = acetate + H(+) + thebaine", "d": []}, {"i": "EC:4.2.99.24", "l": "\"thebaine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165680", "l": "Formation of active mTORC1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112434", "l": "Formation of DSIF complex  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507873", "l": "Aquaporins passively transport urea out of cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42907", "l": "guanosine(748) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106235", "l": "ceramide-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: ceramide-1-phosphate + H2O = ceramide+ phosphate."]}, {"i": "RHEA:50888", "l": "an N-acylsphingoid base 1-phosphate + H2O = an N-acyl-sphingoid base + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58137", "l": "acetate + ATP + H(+) => acetyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76031", "l": "2 H2O2 => O2 + 2 H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67612", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428533", "l": "Inactivation of CDC42 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56731", "l": "4-hydroxy-all-trans-beta-carotene + AH2 + O2 <=> 4,4-dihydroxy-all-trans-beta-carotene + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013021", "l": "GDIs block activation of RHOB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75315", "l": "chloride(out) + D-serine(out) + 2 Na(+)(out) = chloride(in) + D-serine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19140", "l": "17beta-estradiol + AH2 + O2 <=> 6beta-hydroxyestradiol-17beta + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955822", "l": "RUNX1 binds the SOCS4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17015", "l": "3-phosphonopyruvate => H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36004", "l": "(S)-4-hydroxy-2-oxohexanoate => propanal + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65255", "l": "(2E,6E)-farnesyl diphosphate + 6-hydroxymellein <=> diphosphate + verruculide C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24063", "l": "N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30260", "l": "2 a menaquinol + O2 => 2 a menaquinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649735", "l": "Intrinsic nucleotide exchange on RAS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432054", "l": "Aquaporin-1 passively transports water out of cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683755", "l": "Spike protein gets N-glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16453", "l": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O = 2-formylbenzoate + pyruvate", "d": []}, {"i": "EC:4.1.2.34", "l": "\"4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21719", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45894", "l": "an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+) => an N-acylsphing-4-enine + CDP-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250463", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74332", "l": "O-butanoyl-(R)-carnitine(in) => O-butanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30146", "l": "H2O + octanoyl-CoA <=> CoA + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694611", "l": "nsp4 is glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58017", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016648", "l": "oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces disulfide."]}, {"i": "EC:1.5.4.-", "l": "\"With a disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374662", "l": "Translocation of Ezrin to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33086", "l": "dehypoxanthine futalosine + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22484", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate = GMP + GTP + 2 H(+)", "d": []}, {"i": "EC:3.6.1.17", "l": "\"bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445705", "l": "Release Of ADP From Myosin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43054", "l": "3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate => 3-(methylsulfanyl)propanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59205", "l": "docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56382", "l": "(4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38228", "l": "(9Z)-octadecenoyl-CoA + hexadecan-1-ol => CoA + hexadecanyl (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32745", "l": "acetate + H(+) + L,L-cystathionine => L-homocysteine + O-acetyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25568", "l": "ATP + beta-D-ribosylnicotinate = ADP + H(+) + nicotinate beta-D-ribonucleotide", "d": []}, {"i": "EC:2.7.1.173", "l": "\"nicotinate riboside kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641229", "l": "TLE oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52415", "l": "4-phospho-D-erythronate + NAD(+) <=> 3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632677", "l": "PTCH is internalized (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193684", "l": "p62 recruits an atypical PKC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37770", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018758", "l": "RHOH binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701485", "l": "Active ALK binds JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22767", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32886", "l": "(11R)-dihydroartemisinic aldehyde + NADP(+) <=> (+)-artemisinic aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31212", "l": "ATP + H2O + L-selenomethionine => diphosphate + L-adenosylselenomethionine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60820", "l": "H2O + NADPH = adenosine 2',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19246", "l": "N-phenylhydroxylamine => 2-aminophenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53500", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432010", "l": "Aquaporin-1 passively transports water into cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42436", "l": "L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] = L-ascorbate 6-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.194", "l": "\"protein-N(pi)-phosphohistidine--L-ascorbate phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49915", "l": "(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64678", "l": "butyl 3-(methylsulfanyl)propanoate + CoA => 3-(methylsulfanyl)propanoyl-CoA + butan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209960", "l": "Diiodinated tyrosine can be deiodinated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14901", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = casbene + diphosphate", "d": []}, {"i": "EC:4.2.3.8", "l": "\"casbene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21096", "l": "3-dehydroquinate = 3-dehydroshikimate + H2O", "d": []}, {"i": "EC:4.2.1.10", "l": "\"3-dehydroquinate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0051981", "l": "copper chelate transmembrane transporter activity", "d": ["Enables the transfer of a copper chelate from one side of a membrane to the other. A copper chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047091", "l": "L-lysine 6-monooxygenase (NADPH) activity", "d": ["Catalysis of the reaction: L-lysine + NADPH + O2 = N(6)-hydroxy-L-lysine + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70726", "l": "sitosterol(out) <=> sitosterol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202291", "l": "Activation of Lck (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669012", "l": "EDA binds EDAR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.31", "l": "\"D-tagatose 3-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008714", "l": "AMP nucleosidase activity", "d": ["Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665406", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55929", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] => fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71201", "l": "L-ornithine(out) => L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381091", "l": "IRE1 dimer autophosphorylates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426566", "l": "Interaction of DAP12 and CLM7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30794", "l": "dGTP + pyruvate <=> dGDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73908", "l": "4-hydroxy-N,N,N-trimethyltryptamine + ATP => ADP + aeruginascin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55419", "l": "biochanin A + UDP-alpha-D-glucose <=> biochanin A 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69068", "l": "RFC dissociates after sliding clamp formation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654573", "l": "Activated FGFR1 binds SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12312", "l": "dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 = 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.14.22", "l": "\"dibenzothiophene sulfone monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693598", "l": "ATM phosphorylates NBN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.5.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25760", "l": "ent-copalyl diphosphate => diphosphate + ent-isokaurene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35118", "l": "4-coumaroyl-CoA + H(+) + malonyl-CoA <=> (4-coumaroyl)acetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34456", "l": "all-trans-beta-carotene => 9-cis-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102921", "l": "mannosylglycerate synthase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose + D-glycerate <=> H+ + 2-(alpha-D-mannosyl)-D-glycerate + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40846", "l": "FAD + H(+) + octadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16134", "l": "H2O + N(1)-acetylspermine + O2 => 3-aminopropanal + H2O2 + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034910", "l": "6-hydroxy-3-succinoylpyridine hydrolase activity", "d": ["Catalysis of the reaction: 6-hydroxy-3-succinoylpyridine + H2O = succinic semialdehyde + 2,5-dihydroxypyridine."]}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0016888", "l": "endodeoxyribonuclease activity, producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25669", "l": "(2E)-geranyl diphosphate <=> beta-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938108", "l": "SERPINB13 binds cathepsin L (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27954", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + presilphiperfolan-8beta-ol", "d": []}, {"i": "EC:4.2.3.74", "l": "\"presilphiperfolanol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682011", "l": "LC3 binds ATG7 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451347", "l": "Activation of JNK by DSCAM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371467", "l": "SIRT1 deacetylates HSF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14674", "l": "a polar amino acid(out) + ATP + H2O => a polar amino acid(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43668", "l": "ATP + hexacosanoyl-CoA + hydrogencarbonate = 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59436", "l": "4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein] = 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852324", "l": "GTSE1 binds PLK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051407", "l": "glycerone phosphate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerone phosphate(out) + phosphate(in) = glycerone phosphate(in) + phosphate(out)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047218", "l": "hydroxycinnamate 4-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: 4-coumarate + UDP-D-glucose = 4-O-beta-D-glucosyl-4-hydroxycinnamate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731924", "l": "EDNRA binds EDNs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013110", "l": "RHOC binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65586", "l": "8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-casbene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617852", "l": "FOXO3,FOXO4,(FOXO1) bind GADD45A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029451", "l": "Activation of RAC1 by VAV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708557", "l": "FBXL17 binds BACH1:MAFK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803527", "l": "ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54871", "l": "(2E)-butenoyl-[ACP] + H(+) + NADH <=> butanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.3", "l": "\"mitochondrial protein-transporting ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53305", "l": "AH2 + 2 ATP + 2 cob(II)alamin => A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73825", "l": "an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042975", "l": "peroxisome proliferator activated receptor binding", "d": ["Binding to a peroxisome proliferator activated receptor, alpha, beta or gamma."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114544", "l": "p115-RhoGEF activation of RHOA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21890", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate + H(+) + NADPH => (1S,2S)-OPC-8 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610720", "l": "PKA phosphorylates GLI3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.13", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.240751554780076", "identifiers": [{"i": "GO:1901681", "l": "sulfur compound binding", "d": ["Binding to a sulfur compound."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683622", "l": "mRNA5 is translated to protein M (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662608", "l": "MT2A binds cadmium (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30896", "l": "H2O + O2 + propane-1,3-diamine => 3-aminopropanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71783", "l": "MDH2 reduces OA to MAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15652", "l": "carbamate + 2 H(+) <=> CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38175", "l": "all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73789", "l": "diphosphate + variecolorin L => dimethylallyl diphosphate + tardioxopiperazine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35216", "l": "H2O + XDP => H(+) + phosphate + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34893", "l": "selenite(out) => selenite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18782", "l": "H(+) + malonyl-CoA => acetyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.42", "l": "\"D-threonine aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24219", "l": "(2E,6E)-farnesal + H2O + NAD(+) <=> (2E,6E)-farnesoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209924", "l": "Dopa is decarboxylated to dopamine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53090", "l": "2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine => 2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15266", "l": "1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate => H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430183", "l": "NCK binds PAK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654425", "l": "Activated FGFR4 binds SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17562", "l": "acetylcholine + H2O => acetate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047573", "l": "4-acetamidobutyrate deacetylase activity", "d": ["Catalysis of the reaction: 4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35442", "l": "CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine <=> archaetidylserine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36425", "l": "2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine => 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654510", "l": "FGFRL1 binds SPRED1/2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17603", "l": "ADP + D-ribulose 5-phosphate + H(+) => ATP + D-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.102", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928620", "l": "PAK1 autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32669", "l": "H(+) + hydrogen sulfide + methyl-coenzyme M => coenzyme M + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38127", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol = 1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016156", "l": "fumarate reductase (NADH) activity", "d": ["Catalysis of the reaction: NAD+ + succinate = fumarate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606564", "l": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16680", "l": "fluoroacetaldehyde + H2O + NAD(+) <=> fluoroacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28759", "l": "beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose = alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.325", "l": "\"TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26246", "l": "geranylgeranyl diphosphate => diphosphate + fusicocca-2,10(14)-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40303", "l": "A + dodecanedioyl-CoA = (2E)-dodecenedioyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047444", "l": "N-acylneuraminate-9-phosphate synthase activity", "d": ["Catalysis of the reaction: H2O + phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate = phosphate + N-acylneuraminate 9-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36202", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9017817", "l": "Gamma-secretase cleaves YBX1:NOTCH3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709360", "l": "H2O2 reduces MetHb (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0022840", "l": "leak channel activity", "d": ["Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38435", "l": "(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008803", "l": "bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity", "d": ["Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37117", "l": "CoA + H(+) + N-tetracosanoyl-sphing-4-enine => sphing-4-enine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047008", "l": "pregnan-21-ol dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + pregnan-21-ol = H+ + NADPH + pregnan-21-al."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46083", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADH <=> NAD(+) + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72012", "l": "glutathione(in) + urate(out) => glutathione(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76066", "l": "3'-phosphoadenylyl sulfate(in) + adenosine 3',5'-bisphosphate(out) <=> 3'-phosphoadenylyl sulfate(out) + adenosine 3',5'-bisphosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57993", "l": "(20S)-ginsenoside C-K + UDP-alpha-D-glucose => (20S)-ginsenoside F2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46402", "l": "(25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin] => cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42897", "l": "L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62493", "l": "ATP + holo-[peptidyl-carrier protein] + L-arginine => AMP + diphosphate + L-arginyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879459", "l": "F-actin capping protein is a heterodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22471", "l": "GTP + 3 H2O <=> 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805285", "l": "PLK3 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49455", "l": "a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O <=> 6-sulfo-alpha-D-quinovose + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514831", "l": "Fibrillin-1 degradation by MMP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75081", "l": "Formation of AT-AC B Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30109", "l": "2-aminomalonate semialdehyde + H(+) + NADPH => D-serine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675866", "l": "PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672083", "l": "KTN1 binds Kinesin-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12390", "l": "2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => formononetin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42252", "l": "H(+) + malonyl-[ACP] + pentanoyl-CoA = 3-oxoheptanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6790038", "l": "Expression of HSP90B1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20766", "l": "oxaloacetate + propanoyl-CoA => (S)-methylmalonyl-CoA + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65514", "l": "5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2 => 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605717", "l": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047483", "l": "imidazoleacetate-phosphoribosyldiphosphate ligase activity", "d": ["Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazol-4-ylacetate = 1-(5-phosphoribosyl)imidazol-4-ylacetate + ADP + diphosphate + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58002", "l": "(20S)-ginsenoside Rg3 + H(+) + UDP => (20S)-ginsenoside Rh2 + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73797", "l": "FAICAR => IMP + H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70241", "l": "PCK1 phosphorylates OA to yield PEP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72538", "l": "H2O + NADP(+) + vanillin <=> 2 H(+) + NADPH + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38453", "l": "NADPH + (n+1) sulfur => hydrogen sulfide + NADP(+) + n sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24541", "l": "A + D-glucose => AH2 + D-glucono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3858475", "l": "ppDVL recruits RAC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106294", "l": "NADPH oxidase H202-forming activity", "d": ["Catalysis of the reaction: NADPH + H+ + O2 = NADP + hydrogen peroxide (H2O2)."]}, {"i": "RHEA:11260", "l": "H(+) + NADPH + O2 = H2O2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25764", "l": "(2R,3S)-3-methylmalate + NAD(+) => 3-carboxy-2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21746", "l": "1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine => S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106409", "l": "cyclic-di-AMP phosphodiesterase activity", "d": ["Catalysis of the reaction: 3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'-5')-adenosine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047978", "l": "hexadecanol dehydrogenase activity", "d": ["Catalysis of the reaction: hexadecanol + NAD+ = hexadecanal + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.853579598310013", "identifiers": [{"i": "GO:0008194", "l": "UDP-glycosyltransferase activity", "d": ["Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule."]}, {"i": "REACT:R-HSA-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47760", "l": "a uridine in 21S rRNA + S-adenosyl-L-methionine = a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63085", "l": "chloride + FADH2 + ilicicolin B + O2 => FAD + H(+) + 2 H2O + ilicicolin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983156", "l": "Polyubiquitination of substrate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848596", "l": "PTK6 binds PXN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65887", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine <=> H2O + L-glutamate + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46121", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29792", "l": "ATP + glutathione(out) + H2O => ADP + glutathione(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58262", "l": "ADP-D-ribose + L-tyrosyl-[protein] => H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664850", "l": "ATM binds PEX5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57897", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102126", "l": "coniferyl aldehyde 5-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + coniferyl aldehyde + NADPH + O2 <=> 5-hydroxy-coniferaldehyde + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74742", "l": "Phosphorylation of SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63868", "l": "(9Z)-octadecenoate + O2 = (2R,9Z)-2-hydroperoxyoctadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647631", "l": "GSDMD (1-275) binds PIPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60036", "l": "H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate = 3-hydroxy-3-methylhexanoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0004104", "l": "cholinesterase activity", "d": ["Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28848", "l": "Li(+)(in) + melibiose(in) => Li(+)(out) + melibiose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990224", "l": "NMN phosphatase activity", "d": ["Catalysis of the reaction: beta-nicotinamide D-ribonucleotide (NMN-) + H2O = beta-nicotinamide D-riboside (nicotinamide ribose, NmR) + phosphate."]}, {"i": "RHEA:30815", "l": "beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinamide D-riboside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093331", "l": "Ras:GTP binds p120-RasGAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451311", "l": "Activation of Ca-permeable Kainate receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399985", "l": "AKT1 E17K mutant phosphorylates caspase-9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983150", "l": "Proteasomal cleavage of substrate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53931", "l": "a tertiary amine + S-adenosyl-L-methionine <=> a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67440", "l": "H2O + N(alpha)-acetyl-L-methionine = acetate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0042030", "l": "ATPase inhibitor activity", "d": ["Binds to and stops, prevents or reduces an ATP hydrolysis activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58859", "l": "(6E)-8-hydroxygeraniol + NAD(+) <=> (6E)-8-oxogeraniol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69742", "l": "phenylsuccinate + succinyl-CoA <=> 3-phenylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.120", "l": "\"galactose 1-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3301345", "l": "Elongator complex acetylates replicative histone H3, H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010646", "l": "AKAP5 recruits PKC to ROBO3.1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9625482", "l": "PTK2 binds activated EGFR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.58", "l": "\"lipopolysaccharide glucosyltransferase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805620", "l": "KAT6A and PML bind TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798528", "l": "S100A8:S100A9 binds Mn2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49183", "l": "a bacteriochlorophyllide d + S-adenosyl-L-methionine <=> a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54948", "l": "(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] = (2E,5Z)-dodecadienoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.20", "l": "\"phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57418", "l": "L-aspartyl-[protein] + NH4(+) => H2O + L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5591086", "l": "SERPINA5 binds activated protein C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186778", "l": "SHP2 binds to the active receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42679", "l": "L-cysteine + L-histidine + O2 <=> H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814766", "l": "GDPD1 hydrolyzes LysoPtdCho (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018509", "l": "cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity", "d": ["Catalysis of the reaction: cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827870", "l": "SOX17 and TFAP2C bind the TFAP2C gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031418", "l": "L-ascorbic acid binding", "d": ["Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31184", "l": "acetyl-CoA + decanoyl-CoA => 3-oxododecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856808", "l": "Recruitment of AP-2 complex and clathrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9609921", "l": "SGTA binds Tail-anchored protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17084", "l": "(E)-isoeugenol + S-adenosyl-L-methionine <=> (E)-isomethyleugenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25525", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => 9alpha-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47429", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) => 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823952", "l": "EOMES, SMAD2,3, and GATA6 bind the CXCR4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12802", "l": "ATP + L-seryl-[tau protein] => ADP + H(+) + O-phospho-L-seryl-[tau protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44967", "l": "(2E)-dodecenoyl-CoA + H(+) + NADPH <=> dodecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205262", "l": "Direct recruitment of PI3K to p-KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45766", "l": "2 H(+) + L-aspartate + NADH => H2O + L-aspartate 4-semialdehyde + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57920", "l": "4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) = H(+) + L-asparaginyl-tRNA(Asn) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140842", "l": "n fibrin monomers -> fibrin multimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199079", "l": "Epithelial cadherin binds to KLRG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.73", "l": "\"inosine/xanthosine triphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.15", "l": "\"diaminopropionate ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951499", "l": "Loading of antigenic peptides on to class I MHC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018573", "l": "NOTCH3 binds activated EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36297", "l": "D-maltose + phosphate => alpha-maltose 6'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42083", "l": "all-trans-retinal + H2O + NAD(+) <=> all-trans-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205136", "l": "GTP-bound RAC contributes to JNK activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50782", "l": "(2E)-octenal + H(+) + NADPH => NADP(+) + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60853", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47528", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isocholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54273", "l": "2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654514", "l": "KAL1 binds FGFR1c (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40096", "l": "26-oxohexacosanoate + H2O + NAD(+) => 2 H(+) + hexacosanedioate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700120", "l": "PTN and MDK bind to PTPRZ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004079", "l": "biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51992", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.43", "l": "\"(methylsulfanyl)alkanaldoxime N-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15120", "l": "3'-dephospho-CoA + ATP <=> 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35122", "l": "(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O <=> bisdemethoxycurcumin + CO2 + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10464", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = n acetate + chitosan", "d": []}, {"i": "EC:3.5.1.41", "l": "\"chitin deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70241", "l": "PCK1 phosphorylates OA to yield PEP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36669", "l": "CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine => (15Z)-tetracosenoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2423785", "l": "CR:atREs binds apoE and HSPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19815", "l": "2-oxosuccinamate + an L-alpha-amino acid => a 2-oxocarboxylate + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35466", "l": "lathosterol + NAD(+) <=> 5alpha-cholest-7-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008707", "l": "4-phytase activity", "d": ["Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.13.-", "l": "\"Protein-histidine kinases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10809", "l": "(S)-2-hydroxypropylphosphonate + H2O2 => (1R,2S)-epoxypropylphosphonate + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41712", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30905", "l": "H(+) + S-adenosyl-L-homocysteine + spheroidene => demethylspheroidene + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24624", "l": "ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)", "d": []}, {"i": "EC:6.1.1.3", "l": "\"threonine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014456", "l": "GDIs block activation of RHOG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40836", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O => 2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012835", "l": "GDIs block activation of RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12489", "l": "2-amino-2-deoxy-D-gluconate => 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68400", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-gurjunene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950175", "l": "Expression of Glutathione S-transferase omega-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23410", "l": "2 H(+) + NADPH + precorrin-6A => NADP(+) + precorrin-6B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13798", "l": "a dolichyl phosphate + H2O => di-trans,poly-cis-dolichol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43561", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28119", "l": "di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose => D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66786", "l": "6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein] => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134946", "l": "DDX41 ubiquitination by TRIM21 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15808", "l": "(7R,8S)-7,8-diammoniononanoate + ATP + CO2 <=> (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41867", "l": "(2E)-decenoyl-[ACP] + H(+) + NADPH <=> decanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54693", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (13E)-labda-7,13-dien-15-yl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23534", "l": "AMP + choloyl-CoA + diphosphate => ATP + cholate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944250", "l": "Association of procollagen type XXV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57452", "l": "L-glutaminyl-[protein] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64337", "l": "H(+) + 2 malonyl-CoA + nicotinyl-CoA => 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660663", "l": "Caspase-8 cleaves IL1B precursor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67156", "l": "1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673797", "l": "NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70788", "l": "H(+)(in) + L-citrulline(in) + L-ornithine(out) => H(+)(out) + L-citrulline(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31718", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50685", "l": "H2O + N(5)-phenyl-L-glutamine => aniline + H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63616", "l": "prunetin + UDP-alpha-D-glucuronate = H(+) + prunetin-C(8)-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22515", "l": "3 H(+) + precorrin-8X <=> hydrogenobyrinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381727", "l": "RAP1A exchanges GDP for GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24497", "l": "4-O-deacetylvindoline + acetyl-CoA => CoA + vindoline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868071", "l": "Clathrin recruits PIK3C2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.13", "l": "\"N(1)-acetylpolyamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13369", "l": "dimethylallyl diphosphate = diphosphate + isoprene", "d": []}, {"i": "EC:4.2.3.27", "l": "\"isoprene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57010", "l": "2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+) => 5,5'-dehydrodivanillate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25748", "l": "L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18725", "l": "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = acetyl-CoA + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22173", "l": "beta-D-fructose 6-phosphate + UDP-alpha-D-glucose => H(+) + sucrose 6(F)-phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73604", "l": "CMP(in) + CTP(out) => CMP(out) + CTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58909", "l": "7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH => C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57903", "l": "2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 <=> adenosine in U6 snRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32730", "l": "a very-long-chain acyl-CoA + H(+) + malonyl-CoA <=> a very-long-chain 3-oxoacyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57756", "l": "2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39332", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757954", "l": "N4BP1 binds IKBKG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16095", "l": "(24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51839", "l": "(9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938328", "l": "RUNX1:CBFB binds the NFE2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246696", "l": "APC truncation mutants are not K63 polyubiquitinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1297444", "l": "Binding of cAMP to HCN channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66693", "l": "dTDP-beta-L-rhamnose + L-arginyl-[protein] => dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645598", "l": "RRAGC,D hydrolyzes GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047310", "l": "glutamine-scyllo-inositol transaminase activity", "d": ["Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone + L-glutamine = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74023", "l": "L-alanine(in) + L-serine(out) = L-alanine(out) + L-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40855", "l": "FAD + H(+) + undecanoyl-CoA = FADH2 + trans-2-undecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432946", "l": "PARVB/Affixin interacts with alpha PIX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22354", "l": "cadaverine + CO2 => H(+) + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205262", "l": "Direct recruitment of PI3K to p-KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15683", "l": "(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH => 2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62110", "l": "a monoacyl-sn-glycero-3-phosphoethanolamine + CoA => an acyl-CoA + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693012", "l": "TNFSF15 binds TNFRSF25 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72131", "l": "agmatine(out) = agmatine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016995", "l": "cholesterol oxidase activity", "d": ["Catalysis of the reaction: cholesterol + O2 = cholest-5-en-3-one + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56092", "l": "bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757574", "l": "ALB binds PREDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23781", "l": "H2O + oxaloacetate + propanoyl-CoA => (2S,3S)-2-methylcitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047742", "l": "chenodeoxycholoyltaurine hydrolase activity", "d": ["Catalysis of the reaction: chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033520", "l": "TYSND1 cleaves TYSND1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798372", "l": "ATM phosphorylates DYRK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72658", "l": "1-hydroxy-6-methoxyphenazine + NADPH + O2 <=> 1-hydroxy-6-methoxyphenazine N(10)-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680408", "l": "BRD4 binds fedratinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849857", "l": "KLK5 cleaves and activates CELA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783883", "l": "P6C transforms to 2AMAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34363", "l": "H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": []}, {"i": "EC:2.7.7.83", "l": "\"UDP-N-acetylgalactosamine diphosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983427", "l": "Expression of peptide bound class I MHC on cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32493", "l": "10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11100", "l": "4-hydroxyhexan-3-one = 2 propanal", "d": []}, {"i": "EC:4.1.2.35", "l": "\"propioin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0030597", "l": "RNA glycosylase activity", "d": ["Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41388", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27854", "l": "(2E)-geranyl diphosphate + 4-hydroxybenzoate = 3-geranyl-4-hydroxybenzoate + diphosphate", "d": []}, {"i": "EC:2.5.1.93", "l": "\"4-hydroxybenzoate geranyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21024", "l": "CoA + glyoxylate + NADP(+) = H(+) + NADPH + oxalyl-CoA", "d": []}, {"i": "EC:1.2.1.17", "l": "\"glyoxylate dehydrogenase (acylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951486", "l": "CD46 binds C4b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61201", "l": "acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804379", "l": "PRMT5 binds TTC5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36099", "l": "benzoate + S-adenosyl-L-methionine = methyl benzoate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.273", "l": "\"benzoate O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25224", "l": "H(+) + L-cysteate <=> CO2 + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560493", "l": "Expression of Perilipin (PLIN) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53837", "l": "a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine => a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11685", "l": "methylarsonous acid + S-adenosyl-L-methionine => dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029270", "l": "Recruitment of PLCgamma to membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669890", "l": "Constitutive phosphorylation of kinase domain KIT mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865275", "l": "PDGF-BB clevage by Furin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28073", "l": "(2E,6E)-farnesyl diphosphate + H2O + heme b <=> diphosphate + Fe(II)-heme o", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62135", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dTTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59278", "l": "D-glutamine => L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211950", "l": "CYP24A1 24-hydroxylates CTL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28498", "l": "formaldehyde + mycothiol = S-(hydroxymethyl)mycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41978", "l": "CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112042", "l": "Opioid binds MOR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53182", "l": "D-erythrulose => D-erythrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937369", "l": "ATAD2 binds ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29144", "l": "a ubiquinol + 2 H(+)(in) + nitrate => a ubiquinone + 2 H(+)(out) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035731", "l": "dinitrosyl-iron complex binding", "d": ["Binding to a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56196", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose = H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174551", "l": "Formation of alternative pathway C5 convertase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655326", "l": "Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794351", "l": "SHARPIN binds SHANK proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57133", "l": "L-ascorbate + O2 + tyramine => (R)-octopamine + H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781905", "l": "ZRANB1 binds APC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59665", "l": "D-cellopentaose + O2 => D-cellopentaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972966", "l": "POU5F1 (OCT4), SOX2, NANOG bind the HHEX promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38574", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) <=> a 1,2-diacyl-sn-glycero-3-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60321", "l": "N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64301", "l": "3-phenylpropylamine + pyruvate => 3-phenylpropanal + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15998", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADH + O2 => 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195378", "l": "Homodimerization of VEGF proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11480", "l": "3-hydroxybenzoate + H(+) + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.23", "l": "\"3-hydroxybenzoate 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-176956", "l": "Formation of GINS complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67553", "l": "3'-phosphoadenylyl sulfate + cholate => adenosine 3',5'-bisphosphate + cholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13514", "l": "(S)-dihydroorotate + NAD(+) => H(+) + NADH + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49016", "l": "aurachin C epoxide = 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806831", "l": "CYB5Rs reduce MetHb to HbA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:1990817", "l": "poly(A) RNA polymerase activity", "d": ["Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30047", "l": "chloroacetaldehyde + H2O + NAD(+) = chloroacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49772", "l": "glycine + hexacosanoyl-CoA = CoA + H(+) + N-hexacosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53332", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55650", "l": "CO2 + H(+) + succinate + validoxylamine B => 2-oxoglutarate + O2 + validoxylamine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74666", "l": "acetylcholine(in) <=> acetylcholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183052", "l": "CBL binds to GRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030380", "l": "interleukin-17E receptor binding", "d": ["Binding to an interleukin-17E receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "72.675373588411375", "identifiers": [{"i": "GO:0097747", "l": "RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18477", "l": "2,3-dihydroxybenzoate + O2 = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)", "d": []}, {"i": "EC:1.13.11.14", "l": "\"2,3-dihydroxybenzoate 3,4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52497", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40203", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707827", "l": "Spike binds Spike inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42215", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O <=> a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62323", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) <=> (+)-isomalbrancheamide B + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52037", "l": "H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate => L-isoleucine + tuberonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879942", "l": "The receptor is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19383", "l": "2-oxoglutarate + CO2 => (S)-oxalosuccinate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.2", "l": "\"glutamate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132269", "l": "Formation of classical C5 convertase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28701", "l": "Mn(2+)(out) => Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44258", "l": "1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034188", "l": "apolipoprotein A-I receptor activity", "d": ["Combining with an apolipoprotein A-I receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47343", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30450", "l": "3-methylxanthine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660530", "l": "Expression of SNCB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75562", "l": "erinacol + O2 + reduced [NADPH--hemoprotein reductase] <=> cyathadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50838", "l": "14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34220", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166792", "l": "Conversion of C2 into C2a and C2b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10491", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP <=> 5,10-methenyltetrahydrofolate + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68381", "l": "3-hydroxypyruvate + L-asparagine => 2-oxosuccinamate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851979", "l": "BTNL9 binds immune cell surfaces (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038164", "l": "thrombopoietin receptor activity", "d": ["Combining with the glycoprotein thrombopoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36400", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) => H(+) + NADPH + zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698844", "l": "MLKL binds HSP90:CDC37 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51443", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52694", "l": "3-phenylpyruvate + H(+) + NADPH => 3-phenyllactate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66719", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate <=> (2S)-3-sulfolactaldehyde + D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30821", "l": "allantoate + H(+) => allantoin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944262", "l": "Association of procollagen type X (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802926", "l": "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74503", "l": "H(+) + NADPH + yaequinolone D = H2O + NADP(+) + penigequinolone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937814", "l": "RUNX3 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164528", "l": "RNase H-mediated cleavage of the template strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052882", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors, with a copper protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a copper protein."]}, {"i": "EC:1.20.9.-", "l": "\"With a copper protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57806", "l": "4-chlorocatechol + NAD(+) + nitrite => 1-chloro-3-nitrobenzene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22566", "l": "a (2E)-enoyl-[ACP] + H(+) + NADPH => a 2,3-saturated acyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47313", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48250", "l": "CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44088", "l": "ATP + CoA + heptanoate = AMP + diphosphate + heptanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5333678", "l": "CPNEs bind PL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50949", "l": "a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O => a 2'-deoxyuridine in single-stranded DNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70805", "l": "4-deoxy-4-sulfo-D-erythrose + D-xylulose 5-phosphate => 6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863471", "l": "LDLR is bound by DAB2 and ARH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34199", "l": "2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 = bracteatin 6-O-beta-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375395", "l": "C5a receptor binds C5a anaphylatoxin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33959", "l": "2-oxoglutarate + neomycin C = 6'''-deamino-6'''-oxoneomycin C + L-glutamate", "d": []}, {"i": "EC:2.6.1.95", "l": "\"neomycin C transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51425", "l": "a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63509", "l": "a 1,2-saturated fatty acid + O2 => a (2R)-2-hydroperoxy fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16764", "l": "chlorohydroquinone + O2 <=> 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33338", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O <=> 1,2-dioctadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295632", "l": "PPA2A dephosphorylates SPRY2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981931", "l": "RAC1 and CDC42 activate PAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29805", "l": "ADP + H(+) + L-valine(in) + phosphate => ATP + H2O + L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140338", "l": "sphingomyelin transfer activity", "d": ["Removes a sphingomyelin from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008917", "l": "lipopolysaccharide N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051434", "l": "BH3 domain binding", "d": ["Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16818", "l": "6-phospho-D-gluconate + NADP(+) => 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102718", "l": "TRIBOA-glucoside methyltransferase activity", "d": ["Catalysis of the reaction: TRIBOA-beta-D-glucoside + S-adenosyl-L-methionine <=> (2R)-DIMBOA glucoside + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21769", "l": "H2O + N-methyl-L-alanine + NADP(+) => H(+) + methylamine + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013438", "l": "RHOD binds effectors at the endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57108", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5220952", "l": "TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0120015", "l": "sterol transfer activity", "d": ["Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140293", "l": "ADP-ribosylglutamate hydrolase activity", "d": ["Catalysis of the reaction: (ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + ADP-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24599", "l": "acetyl-CoA + L-histidine <=> CoA + H(+) + N(alpha)-acetyl-L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177479", "l": "Axonal transport of NGF:Trk complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417927", "l": "P2Y2 receptor binds ATP and UTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52275", "l": "(1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine <=> gramine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13501", "l": "ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate", "d": []}, {"i": "EC:6.3.4.14", "l": "\"biotin carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814831", "l": "TBC1D20 binds RAB1:GTP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15758", "l": "L-homoserine + NAD(+) => H(+) + L-aspartate 4-semialdehyde + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.168", "l": "\"2-dehydropantolactone reductase (Re-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005330", "l": "dopamine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) + Cl-(out)= dopamine(in) + Na+(in) + Cl-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75767", "l": "(9Z)-hexadecenoate + H2O = 10-hydroxyhexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381608", "l": "cAMP activates EPAC2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0005290", "l": "L-histidine transmembrane transporter activity", "d": ["Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60808", "l": "gibberellin A19 + H(+) + O2 = CO2 + gibberellin A20 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38079", "l": "2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691621", "l": "C5 binds C5 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265177", "l": "Exocyst complex formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31428", "l": "(2E,6E)-farnesyl diphosphate => (1S,5S,6R)-alpha-bergamotene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.432445482536949", "identifiers": [{"i": "GO:0019200", "l": "carbohydrate kinase activity", "d": ["Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule."]}, {"i": "REACT:R-HSA-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561072", "l": "OCT3 mediates renal uptake of organic cations (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72807", "l": "L-histidine(out) = L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661157", "l": "USP9X binds Ub-SNCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22569", "l": "ascopyrone M => ascopyrone P", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047765", "l": "caldesmon-phosphatase activity", "d": ["Catalysis of the reaction: caldesmon phosphate + H2O = caldesmon + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51958", "l": "(Z)-2-methylpropanal oxime => (E)-2-methylpropanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806610", "l": "Keratin filament formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428625", "l": "Vesicular inhibitory amino acid transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39318", "l": "(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA <=> (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27847", "l": "(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 => (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63412", "l": "2,4,6-trichlorophenol + FADH2 + O2 = 2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73839", "l": "ATP + H2O + phenol = AMP + 2 H(+) + phenyl phosphate + phosphate", "d": []}, {"i": "EC:2.7.1.238", "l": "\"phenol phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754839", "l": "SARS-CoV-2 9b binds IKBKG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55791", "l": "acetone + H(+) + NADH + O2 <=> H2O + hydroxyacetone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60433", "l": "A + cannabigerolate => AH2 + cannabichromenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41572", "l": "lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31115", "l": "ATP + biotin + H(+) = biotinyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418904", "l": "A1 and A3 receptors bind adenosine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213207", "l": "Formation of collagen networks (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54407", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12089", "l": "an N-acylsphing-4-enine + UDP-alpha-D-glucose => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0090433", "l": "palmitoyl-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + palmitic acid + CoA = AMP + diphosphate + palmitoyl-CoA."]}, {"i": "REACT:R-HSA-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57300", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72399", "l": "2-oxoglutarate(out) + estrone 3-sulfate(in) = 2-oxoglutarate(in) + estrone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420975", "l": "Ca impermeable AMPA receptor ligand binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013006", "l": "RHOA:GTP translocates to the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61832", "l": "sitosterol + UDP-alpha-D-glucose = H(+) + sitosteryl 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28289", "l": "a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981610", "l": "Neuroglobin binds oxygen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404142", "l": "atROL binds RBP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050002", "l": "D-proline reductase (dithiol) activity", "d": ["Catalysis of the reaction: lipoate + 5-aminopentanoate = dihydrolipoate + D-proline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56362", "l": "13-dihydrocarminomycin + H2O + NADP(+) => 13-deoxycarminomycin + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28155", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20709", "l": "ATP + erythritol => ADP + D-erythritol 4-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047209", "l": "coniferyl-alcohol glucosyltransferase activity", "d": ["Catalysis of the reaction: coniferyl alcohol + UDP-D-glucose = coniferin + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55065", "l": "4-methylpentanoyl-CoA + H2O => 4-methylpentanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-213406", "l": "Disassociation of PLC-gamma1 from LAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685939", "l": "3a localizes to the cell membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16066", "l": "2-oxoglutarate + O2 + phytanoyl-CoA => 2-hydroxyphytanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62012", "l": "cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64686", "l": "3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400500", "l": "Synthesis of prepro-Glucose-dependent Insulinotropic Polypeptide (preproGIP) in intestinal K cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507871", "l": "Aquaporins passively transport glycerol out of cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21495", "l": "2,3-dihydroxybenzoate + H(+) <=> catechol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51133", "l": "a purine 2'-deoxyribonucleoside 5'-phosphate + H2O => 2-deoxy-D-ribose 5-phosphate + a purine nucleobase", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015264", "l": "methylammonium channel activity", "d": ["Enables the facilitated diffusion of methylammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Methylammonium is CH3NH2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63267", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 <=> 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102719", "l": "S-adenosyl-L-methionine:eugenol-O-methyltransferase activity", "d": ["Catalysis of the reaction: eugenol + S-adenosyl-L-methionine = H+ + O-methyleugenol + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40399", "l": "1,2-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761834", "l": "NFE2L2 binds the TKT gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23551", "l": "guanosine(966) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444047", "l": "Receptor FFAR3 binds carboxylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322434", "l": "XIAP dissociates from ub-TLE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43169", "l": "adenosine(34) in tRNA + H(+) + H2O => inosine(34) in tRNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31354", "l": "lupan-3beta,20-diol <=> (S)-2,3-epoxysqualene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.39", "l": "\"enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57737", "l": "A + all-trans-3,4-didehydro-13,14-dihydroretinol => AH2 + all-trans-3,4-didehydroretinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71861", "l": "glycochenodeoxycholate(in) => glycochenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400143", "l": "Fatty acid ligands activate PPARA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66588", "l": "a cytidine in 26S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43768", "l": "an alkylamine + L-glutaminyl-[protein] = N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2467775", "l": "Autocleavage of ESPL1 (Separase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68745", "l": "2 (R)-3-phenyllactate + 2 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022A + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071633", "l": "dihydroceramidase activity", "d": ["Catalysis of the reaction: a dihydroceramide + H2O = a fatty acid + dihydrosphingosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57878", "l": "pseudouridine(54) in tRNA => uridine(54) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73047", "l": "guanidinoacetate(in) = guanidinoacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.129", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879942", "l": "The receptor is activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57815", "l": "1-chloro-2-nitrobenzene + NADH + O2 <=> 3-chlorocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44989", "l": "(R)-carnitine + 2-methylpropanoyl-CoA => CoA + O-isobutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29775", "l": "alpha-D-ribose 1-phosphate + ATP = ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.239", "l": "\"alpha-D-ribose-1-phosphate 5-kinase (ATP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18387", "l": "acetoacetate + 2 AMP + 4 H(+) + 4 phosphate => acetone + 2 ATP + 3 H2O + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60366", "l": "H(+)(in) + myo-inositol(in) => H(+)(out) + myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44690", "l": "a fatty acid + glycerol + H(+) => a 2-acylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15803", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071518", "l": "autoinducer-2 kinase activity", "d": ["Catalysis of the reaction: 4,5-dihydroxy-pentane-2,3-dione + ATP = 5-phospho-4-hydroxy-pentane-2,3-dione (P-DPD) + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54949", "l": "(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] => (2E,5Z)-dodecadienoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694721", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72952", "l": "butanoate(out) + 2 Na(+)(out) => butanoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204871", "l": "Interaction of Tie2 and Grb2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34580", "l": "2 2-oxoglutarate + 2 O2 + pentalenolactone D => 2 CO2 + H2O + pentalenolactone F + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13762", "l": "L-methionine + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + S-methyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33895", "l": "NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose = H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose", "d": []}, {"i": "EC:1.1.1.333", "l": "\"decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950504", "l": "IL27 binds CRLF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707683", "l": "PGRMC2 binds Hemes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651828", "l": "PARG dePARylates PARP1,PARP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015476", "l": "hemaglutinin autotransporter activity", "d": ["Enables the transfer of hemaglutinin from the periplasm to the external milieu; the hemaglutinin and the porin are the N- and C-terminal regions of the same protein, respectively."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36580", "l": "dTDP-alpha-D-fucose + NAD(+) => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40043", "l": "ATP + citrate + L-glutamate = ADP + beta-citrylglutamate + H(+) + phosphate", "d": []}, {"i": "EC:6.3.1.17", "l": "\"beta-citrylglutamate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050378", "l": "UDP-glucuronate 4-epimerase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667107", "l": "SIAH1, SIAH2 ubiquitinate SNCAIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68117", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol => a triacylglycerol + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55346", "l": "1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209792", "l": "N-acetylation of serotonin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0016421", "l": "CoA carboxylase activity", "d": ["Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222093", "l": "BRD7 binds TP53 and EP300 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17975", "l": "5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine => diphosphate + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15908", "l": "3-hydroxycyclohexanone + A <=> AH2 + cyclohexane-1,3-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388831", "l": "Phosphorylation of CD28 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53493", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) => 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008043", "l": "MAPK8 phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.78", "l": "\"(R)-3-[(carboxymethyl)amino]fatty acid dioxygenase/decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047067", "l": "hydrogen:quinone oxidoreductase activity", "d": ["Catalysis of the reaction: H(2) + menaquinone = reduced menaquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341048", "l": "SUMOylation of RXRA with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655142", "l": "RCHY1 binds POLH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15012", "l": "(6S)-5,6,7,8-tetrahydrofolate + NADP(+) <=> 7,8-dihydrofolate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683888", "l": "LMCD1 binds GATA6, sequestering it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11664", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate = 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)", "d": []}, {"i": "EC:2.4.3.5", "l": "\"galactosyldiacylglycerol alpha-2,3-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73539", "l": "dCTP(out) + UTP(in) = dCTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928614", "l": "EFNB:GRB4 binds GIT1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66463", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O <=> 14betaH-scalarane-17alpha-19-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103016", "l": "tRNA-specific 2-thiouridylase activity", "d": ["Catalysis of the reaction: ATP + H+ + a tRNA uridine34 + a [TusE sulfur carrier protein]-S-sulfanylcysteine = AMP + diphosphoric acid + a tRNA 2-thiouridine34 + a [TusE sulfur carrier protein]-L-cysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69533", "l": "(2S)-2-amino-4-deoxychorismate => 4-amino-4-deoxychorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11177", "l": "kojibiose + phosphate => beta-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38558", "l": "an all-trans-retinyl ester + H2O <=> a fatty acid + all-trans-retinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-990489", "l": "Kinesin-13 is a dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050230", "l": "purine imidazole-ring cyclase activity", "d": ["Catalysis of the reaction: DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59350", "l": "D-maltobionate + H(+) => D-maltobiono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0016819", "l": "hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides", "d": ["Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-."]}, {"i": "EC:3.6.2.-", "l": "\"In sulfonyl-containing anhydrides\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380042", "l": "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70976", "l": "3-sulfino-L-alanine(out) + L-aspartate(in) => 3-sulfino-L-alanine(in) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102992", "l": "2-methylbutyronitrile hydroxylase activity", "d": ["Catalysis of the reaction: H+ + 2-methylbutyronitrile + NADPH + O2 <=> H2O + NADP + 2-hydroxy-2-methylbutyronitrile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29922", "l": "alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP <=> ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209536", "l": "IkB is ubiquitinated and degraded (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432148", "l": "Fgr may phosphorylate p38 MAPK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19436", "l": "ATP + D-gluconate <=> 6-phospho-D-gluconate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140851", "l": "histone H3K14 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 3 at the lysine-14 residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63672", "l": "(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH = H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29073", "l": "a ubiquinol + CO2 => a ubiquinone + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376419", "l": "Formation of NR-MED1 Coactivator Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13281", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.178", "l": "\"3-hydroxy-2-methylbutyryl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38225", "l": "1-O-decyl-(9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + decan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140398", "l": "versicolorin B desaturase activity", "d": ["Catalyzes the reaction: versicolorin B + NADPH + O2 <=> versicolorin A + NADP+ + 2 H2O. Uses heme-thiolate as a co-factor. Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49447", "l": "(2-aminobenzoyl)acetyl-CoA + H2O <=> (2-aminobenzoyl)acetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936963", "l": "IRAK2 induces TRAF6 oligomerization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14522", "l": "(2E)-geraniol + NADP(+) => (2E)-geranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139895", "l": "tBID activates BAK protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001632", "l": "leukotriene B4 receptor activity", "d": ["Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53586", "l": "7-oxoresolvin D2 + H(+) + NADH => NAD(+) + resolvin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009541", "l": "ESR1 binds to TFF1 gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24377", "l": "apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin => AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66097", "l": "3-phenylpyruvate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57713", "l": "(E)-sinapaldehyde + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690873", "l": "ACO1 binds 4Fe-4S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42524", "l": "uridine(1911/1915/1917) in 23S rRNA = pseudouridine(1911/1915/1917) in 23S rRNA", "d": []}, {"i": "EC:5.4.99.23", "l": "\"23S rRNA pseudouridine(1911/1915/1917) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14927", "l": "D-mannose 6-phosphate + H(+) + NADPH => D-mannitol 1-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58585", "l": "dihydroprecondylocarpine acetate => (-)-tabersonine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19985", "l": "NAD(+) + S-(hydroxymethyl)glutathione = H(+) + NADH + S-formylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40259", "l": "(2E)-hexadecenedioyl-CoA + H2O = (3S)-hydroxyhexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264615", "l": "Loading of acetylcholine in synaptic vesicles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592398", "l": "Activation of proMMP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73548", "l": "GTP(out) + UTP(in) => GTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730856", "l": "Autophosphorylation of PAK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810843", "l": "Envoplakin binds periplakin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165195", "l": "GTP loading by Rheb (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40538", "l": "4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30499", "l": "H(+) + N,N-dihydroxy-L-valine = (E)-2-methylpropanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005018", "l": "platelet-derived growth factor alpha-receptor activity", "d": ["Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18466", "l": "L-dopa + O2 => 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64225", "l": "AH2 + O2 + uridine(34) in tRNA => 5-hydroxyuridine(34) in tRNA + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169188", "l": "SHP1 (PTPN6) dephosphorylates JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473596", "l": "Collagen type I degradation by MMP15 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36209", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.3", "l": "\"glutamate dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30492", "l": "L-valine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70024", "l": "4-hydroxy-L-proline(in) + Na(+)(in) => 4-hydroxy-L-proline(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19334", "l": "H(+) + oxalyl-CoA => CO2 + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169192", "l": "PTP1B dephosphorylates GHR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007631", "l": "E2F6 binds RBBP4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114284", "l": "Release of Cytochrome c from mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16284", "l": "ATP + dihydrostreptomycin 6-phosphate <=> ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48125", "l": "ganglioside GD3 (d18:1(4E)) + H2O => ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53400", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18136", "l": "ATP + H(+) + sulfate <=> adenosine 5'-phosphosulfate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389862", "l": "Conversion of glyoxylate to oxalate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59315", "l": "D-galactose + O2 <=> D-galactono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12303", "l": "S-adenosyl-L-methionine + uridine(47) in tRNA(Phe) <=> 3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.12", "l": "\"N-hydroxy-2-acetamidofluorene reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62053", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798129", "l": "TP53 binds the CASP6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45486", "l": "acetaldehyde + CO2 => H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.21", "l": "\"L-carnitine CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187261", "l": "COLEC12 (SCARA4) binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754964", "l": "ADA deamidates RBV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013158", "l": "CDC42 GDIs block activation of CDC42 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350486", "l": "DSH binds to FZ at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67709", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5681987", "l": "LC3 is cleaved by ATG4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51199", "l": "chloride(out) + Na(+)(out) + serotonin(out) <=> chloride(in) + Na(+)(in) + serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047289", "l": "galactosyldiacylglycerol alpha-2,3-sialyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + CMP-N-acetyl-beta-neuraminate = 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68190", "l": "CoA + dodecanoate phytyl ester => dodecanoyl-CoA + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781840", "l": "ERCC6 binds stalled RNA Pol II (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73445", "l": "CO2 + formaldehyde + H(+) + nevadensin + succinate => 2-oxoglutarate + gardenin B + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.176", "l": "\"cellulose 1,4-beta-cellobiosidase (reducing end)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670418", "l": "Phosphorylation of JAK2 downstream of KIT mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17665", "l": "L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]", "d": []}, {"i": "EC:2.3.1.181", "l": "\"lipoyl(octanoyl) transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38227", "l": "(9Z)-octadecenoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17322", "l": "L-tryptophan + S-adenosyl-L-methionine => 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209924", "l": "Dopa is decarboxylated to dopamine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18701", "l": "arsenite + H2O + 2 oxidized [azurin] = arsenate + 3 H(+) + 2 reduced [azurin]", "d": []}, {"i": "EC:1.20.9.1", "l": "\"arsenate reductase (azurin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954056", "l": "E2F6 binds TFDP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-445079", "l": "Phosphorylation of L1 by ERK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251942", "l": "Hikeshi binds HSP70s:ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17552", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine <=> 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51508", "l": "2-oxoglutarate + L-proline + O2 = CO2 + succinate + trans-4-hydroxy-L-proline", "d": []}, {"i": "EC:1.14.11.57", "l": "\"L-proline trans-4-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28491", "l": "H(+)(in) + K(+)(in) => H(+)(out) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.5", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050287", "l": "sorbose 5-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: L-sorbose + NADP+ = 5-dehydro-D-fructose + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13777", "l": "ATP + D-ribose 5-phosphate + NH4(+) = 5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.4.7", "l": "\"ribose-5-phosphate--ammonia ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16593", "l": "3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.88", "l": "\"8-hydroxyquercetin 8-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0030249", "l": "guanylate cyclase regulator activity", "d": ["Modulates the activity of guanylate cyclase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9737780", "l": "MTTP binds lomitapide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53915", "l": "butanoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693598", "l": "ATM phosphorylates NBN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39942", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24932", "l": "H2O + L-cysteine => H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39569", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25599", "l": "(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41610", "l": "2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha,alpha-trehalose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52868", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54019", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168848", "l": "tBID binds to inactive BAK protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705926", "l": "AR binds AR agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55132", "l": "ATP + D-alanine + holo-[D-alanyl-carrier protein] = AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate", "d": []}, {"i": "EC:6.2.1.54", "l": "\"D-alanine--[D-alanyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870469", "l": "RGGT geranylgeranylates RAB proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047370", "l": "succinate-citramalate CoA-transferase activity", "d": ["Catalysis of the reaction: S-citramalate + succinyl-CoA = citramalyl-CoA + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56663", "l": "7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24556", "l": "5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.65", "l": "\"5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23479", "l": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) <=> (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31833", "l": "delta-guaiene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050342", "l": "tocopherol O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53055", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate <=> 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74683", "l": "2 AH2 + 2 archaeol + 4 S-adenosyl-L-methionine = 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether + 4 H(+) + 4 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20494", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine => an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23604", "l": "kievitone hydrate = H2O + kievitone", "d": []}, {"i": "EC:4.2.1.95", "l": "\"kievitone hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071558", "l": "histone H3K27me2/H3K27me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683774", "l": "p-T68-CHEK2 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874685", "l": "CBL binds MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21249", "l": "a ribonucleoside 5'-triphosphate + RNA(n) => diphosphate + RNA(n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604763", "l": "Autocatalytic activation of MMP7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55393", "l": "an adenosine in mRNA + S-adenosyl-L-methionine => an N(1)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030197", "l": "extracellular matrix constituent, lubricant activity", "d": ["Functions as a lubricant for an extracellular matrix, such as a mucous membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112429", "l": "Formation of FACT complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43982", "l": "15-hydroxyhexadecanoate + H2O + NADP(+) => H(+) + hexadecanoate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62966", "l": "alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+) => beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71042", "l": "L-methionine(in) + L-phenylalanine(out) <=> L-methionine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15466", "l": "ATP + sphinganine => ADP + H(+) + sphinganine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53627", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + tsukubadiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20774", "l": "5-amino-6-(D-ribitylamino)uracil + riboflavin => 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10425", "l": "H2O + N-benzoylglycine => benzoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701556", "l": "IL2RG gene expression downstream of ALK signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451900", "l": "IL2RB binds JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15070", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a => chlorophyllide a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426223", "l": "Cation influx mediated by TRPC3/6/7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16096", "l": "(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645428", "l": "ALPK1 binds ADP-heptose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54137", "l": "cytidine(48) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62867", "l": "7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine <=> 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46143", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63360", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2 = (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61862", "l": "epoxybetaenone + H2O + NADP(+) => dehydroprobetaenone I + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76063", "l": "3'-phosphoadenylyl sulfate(in) + adenosine 3',5'-bisphosphate(out) = 3'-phosphoadenylyl sulfate(out) + adenosine 3',5'-bisphosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74255", "l": "H2O + L-homoseryl-tRNA(Ser) = H(+) + L-homoserine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68368", "l": "3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose = 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56861", "l": "a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate => a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4608855", "l": "PRICKLE1 is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9727349", "l": "XDH dehydrogenates xanthine to form urate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33019", "l": "(3S)-3,6-diaminohexanoate + acetyl-CoA = (3S)-6-acetamido-3-aminohexanoate + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.264", "l": "\"beta-lysine N(6)-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75181", "l": "(R)-axinyssene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166214", "l": "FA anion flip-flops to the opposite surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592241", "l": "Expression of SSBP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62736", "l": "1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate = 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56224", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865546", "l": "FOXP3 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39126", "l": "(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O <=> (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69943", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27362", "l": "chloride + S-adenosyl-L-methionine => chloromethane + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65571", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61907", "l": "betaenone A + H(+) + NADPH + O2 <=> H2O + NADP(+) + stemphyloxin II", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035614", "l": "snRNA stem-loop binding", "d": ["Binding to a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0055102", "l": "lipase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9761474", "l": "AMOT-2 binds CDH11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0009036", "l": "type II site-specific deoxyribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668904", "l": "Formation of the CTF18 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0005214", "l": "structural constituent of chitin-based cuticle", "d": ["The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0000149", "l": "SNARE binding", "d": ["Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421831", "l": "trans-Golgi Network Coat Assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54787", "l": "Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide <=> Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140931", "l": "neutral L-amino acid:sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) + Cl-(out) = neutral L-amino acid(in) + Na+(in)+ Cl-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15234", "l": "Fe(III)-[cytochrome c] + H2O + nitric oxide => Fe(II)-[cytochrome c] + 2 H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956676", "l": "YAP1 binds TP73 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75244", "l": "FASL binds FAS Receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004358", "l": "glutamate N-acetyltransferase activity", "d": ["Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24447", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161673", "l": "PGD2 is dehydrated to 15d-PGD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19858", "l": "a 16alpha-hydroxysteroid + NADP(+) => a 16-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54279", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 <=> (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24708", "l": "(6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose => (6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61866", "l": "A + probetaenone I => AH2 + dehydroprobetaenone I", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0072586", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity", "d": ["Binds to and modulates the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21483", "l": "2-furoyl-CoA + A + H2O <=> 5-hydroxy-2-furoyl-CoA + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420975", "l": "Ca impermeable AMPA receptor ligand binding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001876", "l": "lipoarabinomannan binding", "d": ["Binding to lipoarabinomannan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20220", "l": "H(+) + trimethylamine N-oxide <=> dimethylamine + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36191", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41024", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692376", "l": "BCL2 binds BCL2 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6783530", "l": "gp130:JAKs bind CNTFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654159", "l": "Activated FGFR2 binds PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71915", "l": "2 Na(+)(out) + tauronorcholate(out) = 2 Na(+)(in) + tauronorcholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637808", "l": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-376419", "l": "Formation of NR-MED1 Coactivator Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432593", "l": "Cytosolic JET binds to CRY, facilitating its ubiquitination (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51240", "l": "(9Z,12Z)-octadecadienoate + O2 = (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388468", "l": "AVP(20-28) binds AVPR1A,B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888589", "l": "Release of GABA at the synapse (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656261", "l": "Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445705", "l": "Release Of ADP From Myosin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714483", "l": "RAC2 translocates to the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018807", "l": "RAC3 GDIs block activation of RAC3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47976", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48017", "l": "4-methyl-5-nitrocatechol + NADH + O2 => 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1606288", "l": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730842", "l": "PI3K associates with phosphorylated GAB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31821", "l": "5-epi-alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50295", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49722", "l": "CO2 + 2 H2O + NAD(+) + violacein => 2 H(+) + NADH + 2 O2 + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357927", "l": "MLKL oligomerizes  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952996", "l": "E2F7 forms homodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626817", "l": "PKC phosphorylates NCF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3785768", "l": "MRN complex binds DNA double strand breaks (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102473", "l": "eriodictyol dibenzoylmethane tautomer 8C-glucosyltransferase activity", "d": ["Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose <=> 8C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP(3-) + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45661", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22404", "l": "beta-D-galacturonate + NAD(+) = D-galactaro-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71119", "l": "H(+) + hispidin + NADPH + O2 = 3-hydroxyhispidin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19868", "l": "4 H(+) + uroporphyrinogen III <=> 4 CO2 + coproporphyrinogen III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43711", "l": "ATP + H(+) + hexadecanoate <=> diphosphate + hexadecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50188", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.4.3", "l": "\"L-arginine:L-lysine amidinotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13117", "l": "O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)", "d": []}, {"i": "EC:2.5.1.51", "l": "\"beta-pyrazolylalanine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374669", "l": "L1 binds NRP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658438", "l": "SPRED dimer binds NF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375138", "l": "CDO binds BOC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13282", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) => 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47595", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) <=> CMP + ganglioside GP1c (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374899", "l": "Release of noradrenaline  at the synapse (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693590", "l": "SARS-CoV-1 dsRNA intermediates bind IFIH1:TKFC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004799", "l": "thymidylate synthase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66440", "l": "butan-2-one + NADP(+) = but-3-en-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45038", "l": "3 Fe(II)-[cytochrome c] + 3 H(+) + nitric oxide => 3 Fe(III)-[cytochrome c] + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57135", "l": "L-ascorbate + O2 + tyramine <=> (R)-octopamine + H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043295", "l": "glutathione binding", "d": ["Binding to glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45040", "l": "2 Fe(III)-[cytochrome c] + hydroxylamine = 2 Fe(II)-[cytochrome c] + 2 H(+) + nitroxyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40086", "l": "hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948757", "l": "AKT phosphorylates MKRN1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004615", "l": "phosphomannomutase activity", "d": ["Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55091", "l": "eburicol + S-adenosyl-L-methionine <=> (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372819", "l": "PCK2 phosphorylates OA to yield PEP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.257", "l": "\"N-terminal L-serine N(alpha)-acetyltransferase NatD\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74311", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74181", "l": "a ketone + H(+) + NADPH + NH4(+) => a secondary alkyl amine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161612", "l": "PGH2 is reduced to PGF2a by FAM213B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005364", "l": "maltose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194678", "l": "CYP51A1 demethylates LNSOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76031", "l": "2 H2O2 => O2 + 2 H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332356", "l": "CAMK2 binds MAP3K7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16554", "l": "aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] => H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17631", "l": "alpha,alpha-trehalose(out) => alpha,alpha-trehalose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46648", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA = androst-4-ene-3,17-dione + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58991", "l": "(E)-4-hydroxynon-2-enal + H2O + O2 <=> (E)-4-hydroxynon-2-enoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75226", "l": "H2O + L-fucono-1,4-lactone <=> H(+) + L-fuconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32220", "l": "all-trans-lycopene => gamma-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74625", "l": "AMP(out) + UMP(in) => AMP(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.41", "l": "\"alditol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65853", "l": "a 3-oxo-Delta(1)-steroid + H2O => a 1-hydroxy-3-oxo steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52521", "l": "O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50155", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879281", "l": "mycothiol is cleaved to acetylcysteine and glucosaminylinositol (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627775", "l": "Autophosphorylation of PAK1,2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264615", "l": "Loading of acetylcholine in synaptic vesicles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44742", "l": "H(+) + rifamycin SV + S-adenosyl-L-homocysteine => 27-O-demethylrifamycin SV + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55149", "l": "a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) => a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40911", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32878", "l": "a 1-acyl-sn-glycerol + H2O <=> a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71261", "l": "2 Na(+)(in) + phosphate(in) => 2 Na(+)(out) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14792", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine <=> a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67223", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA + NAD(+) <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110212", "l": "NTHL1 glycosylase mediated recognition and binding of dihydrouracil (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981622", "l": "Myoglobin:oxygen dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672011", "l": "p-AMPK:AMP binds the ULK complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205319", "l": "Interaction of APS and p-KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16087", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380574", "l": "Dopamine synaptic vesicle docking and priming (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111962", "l": "PDE4A,C,D hydrolyse cAMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31300", "l": "H2O + NAD(+) + perillyl aldehyde => 2 H(+) + NADH + perillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40928", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O => (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621289", "l": "PINK1 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65524", "l": "9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase] = 9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69685", "l": "beta-D-glucose + daidzein + H(+) => daidzein 7-O-beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16101", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)", "d": []}, {"i": "EC:2.8.2.5", "l": "\"chondroitin 4-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67551", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O <=> [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785213", "l": "LIPC dimer binds heparin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981892", "l": "Active G alpha (z) binds RGS proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66060", "l": "2-oxohexanoate + L-kynurenine = H2O + kynurenate + L-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109862", "l": "MAP2K2 phosphorylates MAPK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15353", "l": "all-trans-violaxanthin + L-ascorbate = all-trans-antheraxanthin + H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12374", "l": "4-oxohex-2-enedioate + H(+) => 2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024906", "l": "BDNF binds NTRK2 (TRKB) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46225", "l": "(E)-feruloyl-CoA + H2O => (E)-ferulate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663785", "l": "CHRNA9:CHRNA10:AcCho transports Ca2+ from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641205", "l": "RSPO:LGR binds ZNRF3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14970", "l": "S-adenosyl-L-methionine + trans-aconitate => (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788622", "l": "p-Y-STATs dimerize (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938773", "l": "RNF144A polyubiquitinates PRKDC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73951", "l": "(2E,6E)-farnesyl diphosphate = beta-maaliene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68716", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + germacrene D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12665", "l": "a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.81", "l": "\"aminoglycoside N(3)-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462005", "l": "pro-defensin alpha 5 is secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31784", "l": "H2O + tuberculosinyl diphosphate => diphosphate + tuberculosinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65331", "l": "A + chrodrimanin F <=> AH2 + chrodrimanin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675431", "l": "PP2A dephosphorylates RAF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62659", "l": "2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate <=> 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69729", "l": "diphosphate + phenylacetyl-AMP => 2-phenylacetate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.3", "l": "\"exodeoxyribonuclease (lambda-induced)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944236", "l": "Association of procollagen type XIV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9631065", "l": "Substrate translocates into late endosomal lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939201", "l": "ESR dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25494", "l": "(-)-beta-phellandrene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015649", "l": "2-keto-3-deoxygluconate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in)."]}, {"i": "RHEA:29943", "l": "2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) = 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1878002", "l": "XYLTs transfer Xyl to core protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034073", "l": "tetrahymanol cyclase activity", "d": ["Catalysis of the reaction: squalene = tetrahymanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45835", "l": "(3R)-3-hydroxydecanoyl-CoA + NAD(+) <=> 3-oxodecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23513", "l": "alpha,alpha-trehalose + phosphate => beta-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20387", "l": "(2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+) => (2R,3R)-dihydroquercetin + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44998", "l": "CoA + O-3-oxobutanoyl-(R)-carnitine => (R)-carnitine + acetoacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58370", "l": "(2E,6Z)-nona-2,6-dienal + H(+) + NADPH => (2E,6Z)-nona-2,6-dien-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195378", "l": "Homodimerization of VEGF proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19428", "l": "H(+) + imidazole-4-acetate + NADH + O2 <=> 5-hydroxyimidazole-4-acetate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59190", "l": "D-histidine => L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446187", "l": "ALG11 transfers the fourth and fifth Man to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189069", "l": "sucrose + H2O => glucose + fructose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001760", "l": "aminocarboxymuconate-semialdehyde decarboxylase activity", "d": ["Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H+ = 2-aminomuconate 6-semialdehyde + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25028", "l": "H(+) + H2O + S-methyl-5'-thioadenosine <=> NH4(+) + S-methyl-5'-thioinosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13669", "l": "5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) = 3-hydroxy-2-methylpyridine-5-carboxylate + CO2", "d": []}, {"i": "EC:4.1.1.51", "l": "\"3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34581", "l": "2 CO2 + H2O + pentalenolactone F + 2 succinate => 2 2-oxoglutarate + 2 O2 + pentalenolactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061711", "l": "N(6)-L-threonylcarbamoyladenine synthase activity", "d": ["Catalysis of the reaction: L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39591", "l": "(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA = (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507873", "l": "Aquaporins passively transport urea out of cells (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62194", "l": "H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase] => O2 + peregrinol + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944232", "l": "Association of procollagen type XII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62428", "l": "3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA = 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57518", "l": "15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dolabradiene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32046", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate <=> 2 ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49975", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35485", "l": "4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine => 5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36834", "l": "2 caldariellaquinol + n H(+)(in) + O2 <=> 2 caldariellaquinone + n H(+)(out) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35287", "l": "ATP + chloramphenicol(in) + H2O = ADP + chloramphenicol(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50303", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66928", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphospho-guanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40650", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019148", "l": "D-cysteine desulfhydrase activity", "d": ["Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70188", "l": "alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose => cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004510", "l": "tryptophan 5-monooxygenase activity", "d": ["Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070380", "l": "high mobility group box 1 receptor activity", "d": ["Combining with high mobility group box 1 (HMBGB1) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052733", "l": "quinate 3-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: quinate + NADP+ = 3-dehydroquinate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49093", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O => H(+) + hexadecanoate + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28172", "l": "butan-2-one + hydrogen cyanide => (2R)-2-hydroxy-2-methylbutanenitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45665", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873923", "l": "STARD10 binds LPCAT1 and PC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42818", "l": "cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45381", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061768", "l": "magnesium:sodium antiporter activity", "d": ["Catalysis of the reaction: Na+(in) + Mg2+(out) = Na+(out) + Mg2+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37443", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33934", "l": "all-trans-zeaxanthin + O2 <=> (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203977", "l": "SAR1 Activation And Membrane Binding (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.151", "l": "\"premnaspirodiene oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052661", "l": "S-lactaldehyde reductase activity", "d": ["Catalysis of the reaction: (S)-propane-1,2-diol + NAD+ = (S)-lactaldehyde + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660514", "l": "MTF1 dimer:12Zn2+ binds CSRP1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938853", "l": "CDK6 binds RUNX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141409", "l": "Mad1 binds kinetochore (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0019208", "l": "phosphatase regulator activity", "d": ["Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175976", "l": "TMT transfers CH3 from AdoMet to BME (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24105", "l": "7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA => 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26563", "l": "2-succinylbenzoyl-CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63948", "l": "H2O + sphinga-4E,14Z-dienine-1-phosphate = phosphate + sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.3", "l": "\"ferredoxin--NAD(+) reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102178", "l": "4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol + O2 + NADH <=> 4alpha-carboxy-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169919", "l": "Glycosylation of NA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102374", "l": "ursolic aldehyde 28-monooxygenase activity", "d": ["Catalysis of the reaction: ursolic aldehyde + NADPH + O2 + H+ <=> ursolic acid + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56112", "l": "2-all-trans-nonaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445448", "l": "HHIP binds Hedgehog (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004750", "l": "D-ribulose-phosphate 3-epimerase activity", "d": ["Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56961", "l": "a ribonucleoside 5'-triphosphate + pyruvate => a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399950", "l": "Phosphorylation of cofilin by LIMK-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70982", "l": "Fumarate + H2O <=> (S)-Malate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050488", "l": "ecdysteroid UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + ecdysteroid = UDP + glucosyl-ecdysteroid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34560", "l": "1-deoxy-11beta-hydroxypentalenate + NAD(+) => 1-deoxy-11-oxopentalenate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482772", "l": "Release of platelet cytosolic components (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61035", "l": "3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine <=> 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62131", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dGTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70739", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.-", "l": "\"Exoribonucleases producing 5'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48394", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247844", "l": "Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12375", "l": "2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O <=> 4-oxohex-2-enedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45238", "l": "(25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin] => (25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14232", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210881", "l": "Dimerization of Tie2/Ang1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75379", "l": "H2O + L-canavanine = L-homoserine + N-hydroxyguanidine", "d": []}, {"i": "EC:4.4.1.43", "l": "\"canavanine-gamma-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798743", "l": "Exocytosis of secretory granule membrane proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66965", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose => alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14835", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH => (R)-mevalonate + CoA + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099119", "l": "3-demethylubiquinol-8 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-8 = S-adenosyl-L-homocysteine + ubiquinol-8."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63392", "l": "A + Fe(II)-heme o + H2O = AH2 + Fe(II)-heme i", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202709", "l": "JAM2 dimerises (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28972", "l": "H(+)(in) + shikimate(in) => H(+)(out) + shikimate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16074", "l": "2,2-dialkylglycine + H(+) + pyruvate => CO2 + dialkyl ketone + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60174", "l": "(2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA => 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696274", "l": "RND1 binds GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38204", "l": "19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75223", "l": "H2O + L-fucono-1,4-lactone = H(+) + L-fuconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17856", "l": "keto-L-sorbose + O2 <=> 5-dehydro-D-fructose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54727", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21397", "l": "(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) => CO2 + Na(+)(out) + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56797", "l": "ATP + cob(I)alamin-[corrinoid adenosyltransferase] => adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70159", "l": "folate(in) + H(+)(in) = folate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688397", "l": "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21854", "l": "(9Z)-octadecenoate + H2O => (R)-10-hydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5340214", "l": "CYGB binds O2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32607", "l": "(6E)-8-hydroxygeraniol + NADP(+) = (6E)-8-hydroxygeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44133", "l": "2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65237", "l": "3-methylbutanol + acetyl-CoA => 3-methylbutyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30810", "l": "L-pipecolate + NAD(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17453", "l": "5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": []}, {"i": "EC:6.3.4.13", "l": "\"phosphoribosylamine--glycine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389026", "l": "Galanin receptors can bind galanin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48454", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine => ganglioside GA2 (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27667", "l": "(R)-methylmalonyl-CoA + H(+) => CO2 + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21608", "l": "isoliquiritigenin + S-adenosyl-L-methionine = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.154", "l": "\"isoliquiritigenin 2'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62031", "l": "H2O + stigmasteryl 3-beta-D-glucoside <=> D-glucose + stigmasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75884", "l": "NAD(+) => ADP-1-deoxy-1,O(4)-didehydro-D-ribose + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21415", "l": "NAD(+) + sn-glycerol 1-phosphate <=> dihydroxyacetone phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40934", "l": "2-oxoglutarate + L-ornithine + O2 <=> (3S)-3-hydroxy-L-ornithine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42553", "l": "uridine(31) in tRNA => pseudouridine(31) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182988", "l": "Sprouty lures CBL away from EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205136", "l": "GTP-bound RAC contributes to JNK activation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17285", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.336", "l": "\"monoglucosyldiacylglycerol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797553", "l": "Protein 4.1 binds CASK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218805", "l": "PKC autophosphorylates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57388", "l": "(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.167", "l": "\"(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052911", "l": "23S rRNA (guanine(745)-N(1))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanine(745) in 23S rRNA = N(1)-methylguanine(745) in 23S rRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.183", "l": "\"taxoid 2alpha-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797100", "l": "CCNK binds CDK13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74048", "l": "L-alanine(in) + L-valine(out) => L-alanine(out) + L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203070", "l": "Association of profilin with monomeric actin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51521", "l": "(S)-reticuline + S-adenosyl-L-methionine => (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678544", "l": "IL17RA:IL17RE binds IL17C dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043429", "l": "2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-nonaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727607", "l": "MME:Zn2+ binds sacubitrilat (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69070", "l": "A + 2 N(delta)-hydroxy-N(omega)-methyl-L-citrulline + 2 nitric oxide => AH2 + 2 N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250280", "l": "ROS oxidize thioredoxin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5633460", "l": "MDM2 binds TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656781", "l": "Deltarasin binds PDE6D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427514", "l": "eNoSC deacetylates histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656214", "l": "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375395", "l": "C5a receptor binds C5a anaphylatoxin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41438", "l": "cholesteryl (9Z-octadecenoate) + CoA => (9Z)-octadecenoyl-CoA + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018746", "l": "RHOQ binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030767", "l": "3-hydroxyanthranilate 4-C-methyltransferase activity", "d": ["Catalysis of the reaction: 3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018798", "l": "RHOV binds GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54641", "l": "(+)-copalyl diphosphate => (12E)-labda-8(17),12,14-triene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.366", "l": "\"L-idonate 5-dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35447", "l": "(1'S)-averantin + NADP(+) = H(+) + NADPH + norsolorinic acid", "d": []}, {"i": "EC:1.1.1.349", "l": "\"norsolorinic acid ketoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805205", "l": "GPR35 binds kynurenic acid (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48009", "l": "2-hydroxybenzoyl-CoA + H(+) + NADH + O2 => 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13414", "l": "ADP + thymidine => AMP + dTMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73742", "l": "dopamine(in) + 2 H(+)(out) <=> dopamine(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044014", "l": "histone H2BK5 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 5) = CoA + histone H2B N6-acetyl-L-lysine (position 5)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3245898", "l": "TCN1 binds correnoids in the circulation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938930", "l": "RUNX1 binds ELF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134800", "l": "STING dimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43924", "l": "NAD(+) + pregnenolone = H(+) + NADH + pregn-5-ene-3,20-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736953", "l": "FURIN translocates to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43088", "l": "5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41026", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18303", "l": "AMP + diphosphate + GMP + 2 H(+) => ATP + NH4(+) + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875661", "l": "GGA3 associates with activated MET receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13849", "l": "D-arabinose = D-ribulose", "d": []}, {"i": "EC:5.3.1.3", "l": "\"D-arabinose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045551", "l": "cinnamyl-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: cinnamyl alcohol + NADP+ = cinnamaldehyde + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49921", "l": "(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-octanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804741", "l": "MDM2 forms homo- or heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37970", "l": "galactitol + NADP(+) <=> D-galactose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22042", "l": "formate + L-aspartate => H2O + N-formyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73690", "l": "dAMP(out) + phosphate(in) <=> dAMP(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63107", "l": "H(+) + ilicicolin A epoxide + NADPH + O2 <=> 16-hydroxy-ilicicolin A epoxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139898", "l": "Caspase-8 activates BID by cleavage (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31329", "l": "bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+) => 1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-421835", "l": "trans-Golgi Network Vesicle Scission (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448744", "l": "IL20RA binds IL20RB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29542", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062154", "l": "N6-methyl-AMP deaminase activity", "d": ["Catalysis of the reaction: H+ + H2O + N6-methyl-AMP = IMP + methylamine. Can also use N6-methyl-dAMP as a substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690701", "l": "SHP1 binds p-CD22 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70692", "l": "chloride(out) + glycine(out) + 2 Na(+)(out) => chloride(in) + glycine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051539", "l": "4 iron, 4 sulfur cluster binding", "d": ["Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31174", "l": "(3S)-hydroxytetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222512", "l": "Nitric oxide oxidizes to nitrosyl ion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033749", "l": "histone H4R3 demethylase activity", "d": ["Catalysis of the removal of the methyl group from a modified arginine residue at position 3 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41403", "l": "1-hexanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48403", "l": "2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212642", "l": "L-Glutamine transport into neurons (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429694", "l": "CERT1-2 dissociates from the endoplasmic reticulum (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60303", "l": "N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388829", "l": "SHP2 phosphatase binds CTLA-4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029454", "l": "Autophosphorylation of PAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202233", "l": "Inactivation of Lck by Csk (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56187", "l": "globoside Gb4Cer + UDP-alpha-D-galactose <=> globoside NOR1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3828025", "l": "DCN (decorin) degradation by MMP14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61726", "l": "a 3-dehydro-D-glucoside + H(+) + NADH => a D-glucoside + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802914", "l": "RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63819", "l": "ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine <=> AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10990", "l": "2 e(-) + 2 H(+) + 2 nitric oxide => H2O + nitrous oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13475", "l": "H(+) + indole-3-pyruvate + NADH + NH4(+) => H2O + L-tryptophan + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.13", "l": "\"sucrose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56310", "l": "1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451508", "l": "Nuclear translocation of phospho ERK2 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28323", "l": "UDP-alpha-D-glucuronate + wogonin => UDP + wogonin 7-O-beta-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60054", "l": "a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+) => a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29212", "l": "H(+)(out) + inosine(in) => H(+)(in) + inosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47105", "l": "5,10-methylenetetrahydromethanopterin + glycine + H2O => 5,6,7,8-tetrahydromethanopterin + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37299", "l": "H2O + L-alanyl-L-threonine = L-alanine + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71475", "l": "H2O + neurotensin = L-isoleucyl-L-leucine + neurotensin(1-11)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61433", "l": "(R)-8-oxocitronellyl enol + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67169", "l": "2-oxoglutarate + 3-hydroxy-L-phenylalanine => 3-(3-hydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46420", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610732", "l": "GSK3 phosphorylates p-GLI3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868260", "l": "CDK5:p25 phosphorylates GOLGA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23952", "l": "H2O + N-(2-phenylethyl)acetamide = 2-phenylethylamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62001", "l": "3 A + protoporphyrinogen IX => 3 AH2 + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202534", "l": "Ubiquitination of NEMO by TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672011", "l": "p-AMPK:AMP binds the ULK complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14462", "l": "(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose => (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112392", "l": "Resumption of elongation after recovery from pausing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69068", "l": "RFC dissociates after sliding clamp formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17650", "l": "acetyl-[ACP] + malonate => acetate + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55900", "l": "chloride + FADH2 + L-tryptophan + O2 = 6-chloro-L-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45320", "l": "H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine = H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005314", "l": "high-affinity L-glutamate transmembrane transporter activity", "d": ["Enables the transfer of glutamate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551571", "l": "WNT5A binds ROR2 and VANGL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689630", "l": "BAP1 binds BAP1-interacting complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853405", "l": "TPX2 binds AURKA at centrosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032561", "l": "guanyl ribonucleotide binding", "d": ["Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18982", "l": "(R)-pantolactone + NADP(+) => 2-dehydropantolactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51745", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A => a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42631", "l": "S-adenosyl-L-methionine + uridine(747) in 23S rRNA <=> 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176116", "l": "Recruitment and activation of Chk1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0034328", "l": "decanoyltransferase activity", "d": ["Catalysis of the transfer of a decanoyl (CH3-[CH2]8-CO-) group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665696", "l": "ERBB2 TMD/JMD mutants bind trastuzumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31782", "l": "an all-trans-retinyl ester + H2O <=> 13-cis-retinol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54341", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22933", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0032266", "l": "phosphatidylinositol-3-phosphate binding", "d": ["Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46069", "l": "(3E)-nonenoyl-CoA => (2E)-nonenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58032", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29714", "l": "cadaverine(in) + H(+)(in) <=> cadaverine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0030899", "l": "calcium-dependent ATPase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008881", "l": "glutamate racemase activity", "d": ["Catalysis of the reaction: L-glutamate = D-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44977", "l": "(R)-carnitine + propanoyl-CoA => CoA + O-propanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016429", "l": "tRNA (adenine-N1-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140490", "l": "microtubule nucleator activity", "d": ["The action of a molecule that provides a shape mimicking the end of a microtubule to seed the formation of a new microtubule via self-assembly."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49968", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983156", "l": "Polyubiquitination of substrate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375384", "l": "Bombesin-like receptors bind bombesin homologues (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10862", "l": "2-(acetamidomethylene)succinate + NAD(+) => 3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65157", "l": "2-oxoglutarate + O2 + preaustinoid A2 => CO2 + H2O + preaustinoid A3 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9650473", "l": "SERPING1 is secreted (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9680443", "l": "ROCK1,2 bind ROCKi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24021", "l": "2-(N(omega)-L-arginino)succinate => fumarate + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15913", "l": "ATP + thiamine phosphate = ADP + thiamine diphosphate", "d": []}, {"i": "EC:2.7.4.16", "l": "\"thiamine-phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51121", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2 => (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714483", "l": "RAC2 translocates to the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22111", "l": "L-threonine <=> 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29392", "l": "GTP + H2O => diphosphate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71535", "l": "D-glucose 6-phosphate(in) + phosphate(out) = D-glucose 6-phosphate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55729", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] => 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140566", "l": "histone reader activity", "d": ["A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53679", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 <=> 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.169", "l": "\"protein O-GlcNAcase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928645", "l": "EPHB:NMDAR binds TIAM1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67588", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3858489", "l": "ppDVL binds DAAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450551", "l": "AUF1 binds translation and heat shock proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60387", "l": "enterobactin + H2O <=> N-(2,3-dihydroxybenzoyl)-L-serine trimer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8980691", "l": "RHOA GEFs activate RHOA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102754", "l": "chlorophyllide-b:phytyl-diphosphate phytyltransferase activity", "d": ["Catalysis of the reaction: H+ + chlorophyllide b + (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate <=> chlorophyll b + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20105", "l": "ADP + beta-D-fructose 6-phosphate = AMP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.146", "l": "\"ADP-specific phosphofructokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32973", "l": "2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938981", "l": "IL3 gene transcription is stimulated by RUNX1 and ELF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791102", "l": "Expression of C19orf10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388468", "l": "AVP(20-28) binds AVPR1A,B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112434", "l": "Formation of DSIF complex  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007539", "l": "CHEK1 phosphorylates E2F6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60625", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O => 2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21460", "l": "benzoin = 2 benzaldehyde", "d": []}, {"i": "EC:4.1.2.38", "l": "\"benzoin aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32656", "l": "a carboxylate + eugenol + NADP(+) => a coniferyl ester + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31732", "l": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 => 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004651", "l": "polynucleotide 5'-phosphatase activity", "d": ["Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72118", "l": "glycine betaine(out) + Na(+)(out) <=> glycine betaine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69285", "l": "a 17beta-hydroxy steroid + NADP(+) => a 17-oxo steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20285", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate = alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine", "d": []}, {"i": "EC:2.4.1.211", "l": "\"1,3-beta-galactosyl-N-acetylhexosamine phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22215", "l": "(2R,3R)-tartrate <=> (2R,3S)-tartrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72033", "l": "(E)-sinapaldehyde + H2O2 => (E)-sinapyl alcohol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114284", "l": "Release of Cytochrome c from mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211950", "l": "CYP24A1 24-hydroxylates CTL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22518", "l": "ADP + H(+) + N-phosphotaurocyamine => ATP + taurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57353", "l": "O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin => H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65893", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate => H2O + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140771", "l": "ACP-dependent peptidyl-lysine N6-palmitoyltransferase activity", "d": ["Catalysis of the reaction: hexadecanoyl-[ACP] + L-lysyl-[protein] = H+ + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]."]}, {"i": "RHEA:70615", "l": "hexadecanoyl-[ACP] + L-lysyl-[protein] = H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46331", "l": "L-threo-3-phenylserine <=> 3-phenylpyruvate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2509838", "l": "ITPA hydrolyses dITP to dIMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168376", "l": "STIM1 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874080", "l": "SRC phosphorylates PTK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670433", "l": "KIT mutants:PI3K catalyze synthesis of PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42471", "l": "2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O <=> 2-oxopent-4-enoate + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43864", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944538", "l": "miR-22 microRNA binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13681", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.37", "l": "\"DNA (cytosine-5-)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390673", "l": "CHRM2,4 bind acetylcholine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8934446", "l": "Activated PKC phosphorylates SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34150", "l": "2-deoxy-L-scyllo-inosose + L-glutamine <=> 2-deoxy-scyllo-inosamine + 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932327", "l": "NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63306", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68470", "l": "(E)-gamma-bisabolene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757686", "l": "SERPINA6 binds PREDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66587", "l": "3-oxocholestane + A + H2O <=> 25-hydroxy 3-oxocholestane + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68262", "l": "D-serine(out) + Na(+)(out) => D-serine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73202", "l": "maleate(in) + sulfate(out) <=> maleate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44893", "l": "an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose => an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49563", "l": "D-sedoheptulose 7-phosphate <=> (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26129", "l": "(+)-copalyl diphosphate => diphosphate + isopimara-7,15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64826", "l": "1-naphthaleneacetate + NH4(+) => 1-naphthaleneacetamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380586", "l": "loading of Serotonin in synaptic vesicles (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166175", "l": "TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39354", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA <=> (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392195", "l": "Gi activation by P2Y purinoceptor 12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47791", "l": "a cytidine in 28S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39267", "l": "(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66944", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39575", "l": "3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51822", "l": "AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in) => ATP(in) + CoA(in) + decanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35698", "l": "(3S)-versiconol acetate + NADP(+) <=> (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26421", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.155424086811493", "identifiers": [{"i": "GO:0097367", "l": "carbohydrate derivative binding", "d": ["Binding to a carbohydrate derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-421835", "l": "trans-Golgi Network Vesicle Scission (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198714", "l": "ERK5 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72914", "l": "proatranorin III + S-adenosyl-L-methionine <=> atranorin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60657", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850818", "l": "SPINK9 binds KLK5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17544", "l": "an aromatic primary alcohol + O2 <=> an aromatic aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55003", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17106", "l": "malonyl-[ACP] + S-adenosyl-L-methionine => malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34272", "l": "2-nitroimidazole + H2O => 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0003909", "l": "DNA ligase activity", "d": ["Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2129375", "l": "Elastin cross-linking by lysyl oxidase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72366", "l": "chloride(out) + hydrogencarbonate(in) <=> chloride(in) + hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781840", "l": "ERCC6 binds stalled RNA Pol II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0097493", "l": "structural molecule activity conferring elasticity", "d": ["The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174367", "l": "GCL ligates L-Glu to L-Cys (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67955", "l": "an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-very-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52896", "l": "2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin = 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate", "d": []}, {"i": "EC:6.3.5.12", "l": "\"Ni-sirohydrochlorin a,c-diamide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42244", "l": "H(+) + malonyl-[ACP] + propanoyl-CoA = 3-oxopentanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54927", "l": "(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23096", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.49", "l": "\"hydroxymethylpyrimidine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0106130", "l": "purine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: RMP + diphosphate = R + 5-phospho-alpha-D-ribose 1-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36020", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3095889", "l": "MMACHC dealkylates RCbl (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158313", "l": "factor XII -> factor XIIa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22006", "l": "ADP + H(+) + O-phospho-L-seryl-[myosin light chain] => ATP + L-seryl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51966", "l": "2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759332", "l": "AcK-NFE2L2 binds the TXNRD1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51486", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54200", "l": "N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912727", "l": "CBL binds VAV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640302", "l": "Asc.- radical dissociates to AscH- and DeHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58559", "l": "15alpha-stemmadenine intermediate II + H2O <=> (16S)-deshydroxymethyl-stemmadenine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004851", "l": "uroporphyrin-III C-methyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69661", "l": "beta-D-glucose + kaempferol => H2O + kaempferol 3-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10880", "l": "7-methylxanthosine + H2O = 7-methylxanthine + D-ribose + H(+)", "d": []}, {"i": "EC:3.2.2.25", "l": "\"N-methyl nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090438", "l": "camelliol C synthase activity", "d": ["Catalyzes the reaction: (3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24993", "l": "L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190141", "l": "ALAD binds to Pb2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.42", "l": "\"Kdo2-lipid A phosphoethanolamine 7''-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9708275", "l": "PDE4A binds PDE4A inhibitors (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58329", "l": "(Z)-non-6-en-1-ol + NADP(+) => (Z)-non-6-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46860", "l": "3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34077", "l": "a 1-acyl-sn-glycero-3-phosphate + phosphate => an acyl phosphate + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689630", "l": "BAP1 binds BAP1-interacting complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28670", "l": "H(+) + hydroxyacetone + NADH <=> (S)-propane-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180855", "l": "Translocation of Vpr to the mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47403", "l": "3-oxo-(9Z-octadecenoyl)-CoA + CoA <=> (7Z)-hexadecenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56875", "l": "(S)-N-acetyl-1-phenylethylamine + H2O <=> (S)-1-phenylethylamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72672", "l": "The 60S subunit joins the translation initiation complex  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66957", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose => alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22609", "l": "H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate => (2S,6S)-2,6-diaminoheptanedioate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32851", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322431", "l": "XIAP binds TLE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18999", "l": "CDP-choline + diphosphate => CTP + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61235", "l": "H2O + L-isoleucine + O2 <=> (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33202", "l": "butan-1-ol + NAD(+) <=> butanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19057", "l": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O", "d": []}, {"i": "EC:1.11.1.12", "l": "\"phospholipid-hydroperoxide glutathione peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29054", "l": "2 H(+)(in) + H2 + menaquinone-8 <=> 2 H(+)(out) + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17778", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939667", "l": "ITGA5 gene expression is stimulated by RUNX2:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17185", "l": "IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.7.1.7", "l": "\"GMP reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35358", "l": "3-hydroxyisopentadecanoyl-CoA <=> (2E)-13-methyltetradecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9659611", "l": "ANO1 inhibitors bind ANO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46606", "l": "[HPr protein]-L-serine + diphosphate => [HPr protein]-O-phospho-L-serine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5159250", "l": "ATF7IP binds SETDB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72181", "l": "2 Na(+)(in) + tauro-beta-muricholate(in) => 2 Na(+)(out) + tauro-beta-muricholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189406", "l": "4 PBGs bind to form HMB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15491", "l": "9-riburonosyladenine + H(+) + 2 H2O2 => adenosine + H2O + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59066", "l": "luteothin + S-adenosyl-L-homocysteine => demethylluteothin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388833", "l": "Phosphorylation of CTLA-4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665767", "l": "Activated FMNL3 binds G-actin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70310", "l": "beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56742", "l": "GalGb3Cer + H(+) + UDP => globoside Gb3Cer + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33612", "l": "H2O + methyl salicylate => H(+) + methanol + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183051", "l": "CBL ubiquitinates Sprouty (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63902", "l": "(2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O => 2 3-(4-hydroxyphenyl)pyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45851", "l": "(3R)-3-hydroxydodecanoyl-CoA + NADP(+) <=> 3-oxododecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55144", "l": "[(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+) = [4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749609", "l": "BCHE hydrolyzes ASA- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26383", "l": "H(+) + NADPH + succinate semialdehyde => 4-hydroxybutanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663258", "l": "NR1D1 (REV-ERBA) binds heme, the PPARGC1A gene, and recruits corepressors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755734", "l": "SARS-CoV-2 N binds IKBKB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52641", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA => (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008490", "l": "arsenite secondary active transmembrane transporter activity", "d": ["Enables the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19365", "l": "ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.19", "l": "\"phosphoribulokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66518", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018794", "l": "RHOV binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62488", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60062", "l": "alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52398", "l": "CO2 + dihydroxyacetone phosphate + NADH => 4-O-phospho-D-threonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443439", "l": "c-Src binds Raf1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352059", "l": "SLC6A15-mediated amino acid uptake (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30579", "l": "H2O + O-phospho-L-threonine = L-threonine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9702849", "l": "CALCR binds gepants (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64638", "l": "butyl benzoate + CoA => benzoyl-CoA + butan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429992", "l": "PARN deadenylates mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433826", "l": "Phosphorylation of IRF3 by IKK epsilon(IKBKE) complexed with activated TLR3. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.7", "l": "\"DNA-directed DNA polymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47115", "l": "chenodeoxycholate + glycine <=> glycochenodeoxycholate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005503", "l": "all-trans retinal binding", "d": ["Binding to all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197958", "l": "FPGS-2 transforms THF to THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3927959", "l": "SUMOylation of CREBBP with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29374", "l": "dAMP + H2O <=> 2'-deoxyadenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39933", "l": "(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64632", "l": "acetyl-CoA + butan-1-ol = butyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13358", "l": "3-hydroxypropanoate + NAD(+) => 3-oxopropanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30371", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O = (-)-geosmin + acetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9761421", "l": "CDH11 associates with catenins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140761", "l": "sequestered tissue factor -> tissue factor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683831", "l": "CCDC59 binds TTF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49940", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 = (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170674", "l": "Dissociation of the Gi alpha:G olf complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48940", "l": "an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid", "d": []}, {"i": "EC:3.4.13.19", "l": "\"membrane dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203712", "l": "eNOS associates with Caveolin-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62636", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O", "d": []}, {"i": "EC:1.11.1.28", "l": "\"lipoyl-dependent peroxiredoxin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32738", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805126", "l": "AURKB phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62366", "l": "(Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+) => FMN-N(5)-peroxide + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106243", "l": "syn-isopimara-7,15-diene synthase activity", "d": ["Catalysis of the reaction: 9alpha-copalyl diphosphate = diphosphate + syn-isopimara-7,15-diene."]}, {"i": "RHEA:62188", "l": "9alpha-copalyl diphosphate = diphosphate + syn-isopimara-7,15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130151", "l": "Dimerization of DAP12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56148", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphocholine = CoA + hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33154", "l": "(R)-dihydrolipoamide + acetyl-CoA <=> (R)-S(6)-acetyldihydrolipoamide + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.99.1", "l": "\"[Co(II) methylated amine-specific corrinoid protein] reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39141", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA => (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11434", "l": "7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0033699", "l": "DNA 5'-adenosine monophosphate hydrolase activity", "d": ["Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60663", "l": "1,4-benzoquinone + H(+) + NADH <=> hydroquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130706", "l": "MHC class II antigen processing (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23423", "l": "alpha,alpha-trehalose 6-phosphate + H2O <=> alpha,alpha-trehalose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43670", "l": "2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate => ATP + hexacosanoyl-CoA + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008949", "l": "oxalyl-CoA decarboxylase activity", "d": ["Catalysis of the reaction: H+ + oxalyl-CoA = CO2 + formyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103008", "l": "4-chloro-2-methylphenoxyacetate oxygenase activity", "d": ["Catalysis of the reaction: 4-chloro-2-methylphenoxyacetate + 2-oxoglutarate + O2 <=> 4-chloro-2-methylphenol + 2-oxo monocarboxylic acid anion + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50670", "l": "an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21126", "l": "5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65280", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate = 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Ser-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853317", "l": "FGFR3 fusions dimerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49775", "l": "glycine + hexacosanoyl-CoA <=> CoA + H(+) + N-hexacosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62705", "l": "glycyldehydrophenylalanine + H2O => 2,3-didehydrophenylalanine + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40189", "l": "(3R)-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.133", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52921", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58667", "l": "(S)-2-hydroxyglutarate + a quinone <=> 2-oxoglutarate + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72506", "l": "glutarate(in) + prostaglandin F2alpha(out) <=> glutarate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14413", "l": "biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)", "d": []}, {"i": "EC:1.13.11.39", "l": "\"biphenyl-2,3-diol 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37212", "l": "2',3'-cyclophospho-GMP + H2O => guanosine 2'-monophosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56084", "l": "[Rab1 protein]-O-phosphocholine-L-serine + H2O = [Rab1 protein]-L-serine + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11462", "l": "AMP + D-glucose 6-phosphate + H(+) => ADP + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74693", "l": "4 5'-deoxyadenosine + 2 A + a glycerol dibiphytanyl glycerol tetraether phospholipid + 4 H(+) + 4 L-methionine => 2 a 2,3-di-O-phytanyl-sn-glycerophospholipid + 2 AH2 + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.36", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35065", "l": "NH4(+) + pyrazine-2-carboxylate => H2O + pyrazinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33528", "l": "acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol => CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26128", "l": "(+)-copalyl diphosphate = diphosphate + isopimara-7,15-diene", "d": []}, {"i": "EC:4.2.3.44", "l": "\"isopimara-7,15-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11521", "l": "(-)-menthol + UDP-alpha-D-glucose => (-)-menthyl beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042943", "l": "D-amino acid transmembrane transporter activity", "d": ["Enables the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the D-enantiomers of amino acids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11314", "l": "chloride + H(+) + hydroxyatrazine => atrazine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698923", "l": "Binding of the major capsid protein (MCP) to the pPR-AP:pAP complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50602", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] => acetyl-CoA + N-terminal L-seryl-[histone H2A]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102866", "l": "di-homo-gamma-linolenate delta5 desaturase activity", "d": ["Catalysis of the reaction: all-cis-icosa-8,11,14-trienoate + O2 + a reduced electron acceptor <=> arachidonate + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32663", "l": "5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine = 5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.243", "l": "\"2-ketoarginine methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68704", "l": "3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate) = 3alpha-hydroxyetiocholan-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41808", "l": "(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097163", "l": "sulfur carrier activity", "d": ["Covalently binding to sulfur and delivering it to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-500708", "l": "GRIK3 homomer binds glutamate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50966", "l": "NH4(+) + uridine(8) in tRNA => cytidine(8) in tRNA + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654651", "l": "Activated FGFR4 binds FRS3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698003", "l": "FLT3 mutants phosphorylate GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51797", "l": "deoxycohumulone + dimethylallyl diphosphate => colupulone + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9650858", "l": "Meglitinides bind ABCC8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62060", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29446", "l": "H(+)(in) + L-alanine(in) <=> H(+)(out) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110307", "l": "REV1 binds AP-dsDNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71215", "l": "2 Na(+)(out) + thiocyanate(out) = 2 Na(+)(in) + thiocyanate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102832", "l": "verbascose galactinol:ajugose galactosyltransferase activity", "d": ["Catalysis of the reaction: verbascose + alpha-D-galactosyl-(1->3)-1D-myo-inositol <=> ajugose + myo-inositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75853", "l": "all-trans-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56479", "l": "(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49148", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.324", "l": "\"dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose N,N-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10843", "l": "H2O + O-phospho-L-homoserine <=> L-threonine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473184", "l": "Follistatin (FST) binds Activin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49191", "l": "a bacteriochlorophyllide d <=> a 3-vinylbacteriochlorophyllide d + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.3.-", "l": "\"Oximinotransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34260", "l": "(+)-larreatricin + AH2 + O2 => (+)-3'-hydroxylarreatricin + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48197", "l": "H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350604", "l": "Agmatine + H2O <=> putrescine + urea (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11938", "l": "4 CO2 + 4 CoA + trans-resveratrol => 4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.21", "l": "\"ADP-sugar diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17130", "l": "ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide => 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25056", "l": "(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+) => (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-982775", "l": "Growth hormone receptor dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.299", "l": "\"protein N-terminal monomethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60795", "l": "3 2-oxoglutarate + gibberellin A53 + 3 O2 <=> 3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982017", "l": "Active G alpha (q) binds RGS proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50098", "l": "13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033996", "l": "levan fructotransferase (DFA-IV-forming) activity", "d": ["Catalysis of the reaction: beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)]n-D-fructofuranoside = beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)](n-1)-D-fructofuranoside + di-beta-D-fructofuranose 2,6':2',6-dianhydride. This reaction is the production of di-beta-D-fructofuranose 2,6':2',6-dianhydride (DFA IV) by successively eliminating the diminishing (2->6)-beta-D-fructan (levan) chain from the terminal D-fructosyl-D-fructosyl disaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67483", "l": "2-oxoglutarate + O2 + prekainate <=> CO2 + H2O + kainate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694373", "l": "Unphosphorylated nucleoprotein translocates to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102737", "l": "p-coumaroyltriacetic acid synthase activity", "d": ["Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + H2O + 3 malonyl-CoA <=> 4 coenzyme A + 3 carbon dioxide + p-coumaroyltriacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810843", "l": "Envoplakin binds periplakin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71394", "l": "16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) <=> 16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1297354", "l": "Acrosin Cleavage (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848339", "l": "PNPLA5 hydrolyzes TAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74018", "l": "4-hydroxybenzoate + H(+) + phosphate <=> CO2 + H2O + phenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66487", "l": "16alpha-hydroxygypsogenate + UDP-alpha-D-glucose <=> 16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44286", "l": "4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + 2 malonyl-CoA + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445083", "l": "CHL1 interacts with NRP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080007", "l": "S-nitrosoglutathione reductase activity", "d": ["Catalysis of the reaction: glutathione N-hydroxysulfenamide + NADH + H+ = S-nitrosoglutathione + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0009041", "l": "UMP/dUMP kinase activity", "d": ["Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59403", "l": "L-2-aminohexanoate <=> D-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0034323", "l": "O-butanoyltransferase activity", "d": ["Catalysis of the transfer of a butyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51626", "l": "CO2 + dGTP + H2O => formate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784959", "l": "BPHL hydrolyses VACV to ACV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64865", "l": "ITP + oxaloacetate => CO2 + IDP + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63742", "l": "2-phenylethanol + NAD(+) => 2-phenylacetaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25159", "l": "(R)-4'-phosphopantothenate + ATP + L-cysteine <=> AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20679", "l": "1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP => alizarin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654422", "l": "Activated FGFR4 binds FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686711", "l": "Endocytois of SARS-CoV-1 Virion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102708", "l": "S-adenosyl-L-methionine:N-methyl-beta-alanine N-methyltransferase activity", "d": ["Catalysis of the reaction: N-methyl-beta-alanine + S-adenosyl-L-methionine = H+ + N,N-dimethyl-beta-alanine + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250616", "l": "botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052694", "l": "jasmonoyl-isoleucine-12-hydroxylase activity", "d": ["Catalysis of the reaction: jasmonoyl-isoleucine + NADPH + H+ + O2 = 12-hydroxy-jasmonoyl-isoleucine + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24831", "l": "ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate => ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57401", "l": "3-O-acetylpapaveroxine + H2O => acetate + H(+) + narcotine hemiacetal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6795290", "l": "TORC2 complex phosphorylates SGK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395412", "l": "Phosphorylation of SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70201", "l": "5,6-dihydroxyindole => dopaminechrome", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26351", "l": "L-galactose + phosphate => beta-L-galactose 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63261", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH => 4-pyridoxate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033906", "l": "hyaluronoglucuronidase activity", "d": ["Catalysis of the random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55370", "l": "(3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine => (R)-carnitine + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14426", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803719", "l": "TP53 binds ZNF385A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37628", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine => 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034027", "l": "(carboxyethyl)arginine beta-lactam-synthase activity", "d": ["Catalysis of the reaction: N(2)-(2-carboxyethyl)-L-arginine + ATP = AMP + deoxyamidinoproclavaminate + diphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042015", "l": "interleukin-20 binding", "d": ["Binding to interleukin-20."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140631", "l": "aldehyde dehydrogenase (NAD+) inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of aldehyde dehydrogenase (NAD+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443782", "l": "CHL1 interacts with contactin-6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73718", "l": "UBF-1 Binds rDNA Promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11792", "l": "H(+) + NADH + O2 + propene = 1,2-epoxypropane + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.69", "l": "\"alkene monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68249", "l": "L-tyrosine(in) + Na(+)(in) => L-tyrosine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090590", "l": "protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + D-glucosamine(out) = protein histidine + glucosamine-6-phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433451", "l": "JAK2 binds to p-KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19166", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose => 1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70889", "l": "L-glutamine(out) + L-serine(in) + Na(+)(in) => L-glutamine(in) + L-serine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60474", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => (6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0005034", "l": "osmosensor activity", "d": ["Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14513", "l": "ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate", "d": []}, {"i": "EC:6.3.5.6", "l": "\"asparaginyl-tRNA synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63842", "l": "[thioredoxin]-disulfide + H2O + tert-butanol => [thioredoxin]-dithiol + tert-butyl hydroperoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382053", "l": "Translocation of PDGF from ER to Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51716", "l": "ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10328", "l": "an L-glycol + NAD(+) = a 2-hydroxycarbonyl + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003868", "l": "4-hydroxyphenylpyruvate dioxygenase activity", "d": ["Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373717", "l": "DCC interacts with DIP13alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32112", "l": "S-adenosyl-L-methionine + trans-resveratrol => 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39248", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA => (2E,11Z)-eicosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38139", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45113", "l": "gamma-tocopherol + H(+) + NADPH + O2 => 13-hydroxy-gamma-tocopherol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66147", "l": "5-methoxytryptamine + acetyl-CoA <=> CoA + H(+) + melatonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29349", "l": "2 H(+)(out) + orotate(out) => 2 H(+)(in) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218811", "l": "DOCK180:ELMO binds CRK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.3.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70169", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54251", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216222", "l": "COS binds to SMO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12216", "l": "9H-fluoren-9-ol + NAD(+) = 9H-fluoren-9-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25409", "l": "ADP-alpha-D-glucose + D-glucose => ADP + alpha,alpha-trehalose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5632677", "l": "PTCH is internalized (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31033", "l": "beta-D-glucopyranosyl cis-(+)-abscisate + UDP => 2-cis-(+)-abscisate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66288", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140842", "l": "n fibrin monomers -> fibrin multimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35191", "l": "noranthrone + O2 = H2O + norsolorinic acid", "d": []}, {"i": "EC:1.13.12.20", "l": "\"noranthrone monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102542", "l": "aclacinomycin A methylesterase activity", "d": ["Catalysis of the reaction: aclacinomycin A + H2O <=> 15-demethoxy-aclacinomycin A + methanol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42117", "l": "5alpha-androstane-3alpha,17beta-diol + NADP(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57658", "l": "CMP + ganglioside GT1balpha + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.3.16", "l": "\"citrate synthase (unknown stereospecificity)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22421", "l": "cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) => 2 H(+) + maleylacetate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46363", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70512", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48739", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928607", "l": "p-EPHs bind VAV2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22932", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.38", "l": "\"beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709360", "l": "H2O2 reduces MetHb (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20469", "l": "H2O + IMP = D-ribose 5-phosphate + hypoxanthine", "d": []}, {"i": "EC:3.2.2.12", "l": "\"inosinate nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69690", "l": "genistein 7-O-beta-D-glucoside + H2O <=> beta-D-glucose + genistein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6794347", "l": "Homer1,2,3 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12039", "l": "(S)-3-(imidazol-5-yl)lactate + NAD(+) <=> 3-(imidazol-5-yl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002428", "l": "Removal of fibrillar collagen N-propeptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944263", "l": "Association of procollagen type II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10939", "l": "6-decylubiquinone + 2 thiosulfate <=> 6-decylubiquinol + tetrathionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866851", "l": "CFTR transits to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6795290", "l": "TORC2 complex phosphorylates SGK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55196", "l": "2-hydroxyoctadecanoyl-CoA = formyl-CoA + heptadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33764", "l": "a (2E)-enoyl-CoA + H(+) + NADPH => a 2,3-saturated acyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390930", "l": "5-HT2 receptor can bind serotonin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9609921", "l": "SGTA binds Tail-anchored protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.165", "l": "\"exo-1,4-beta-D-glucosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029272", "l": "Release of PLCG from FCGR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41440", "l": "(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 = (1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.46", "l": "\"2-aminoethylphosphonate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67198", "l": "acetate + serotonin => H2O + N-acetylserotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66881", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58434", "l": "(E)-4-oxonon-2-enal + H(+) + NADPH => (E)-4-oxonon-2-en-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0019209", "l": "kinase activator activity", "d": ["Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28332", "l": "H(+) + IDP + phosphate => H2O + ITP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433454", "l": "Phosphorylation of GAB2 by SFKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806957", "l": "MET receptor dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61818", "l": "16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP => 16,17-didehydropregnenolone + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68459", "l": "(S)-3-hydroxyglutaryl-CoA <=> (2E)-glutaconyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50257", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19640", "l": "D-nopaline + H2O + NADP(+) <=> 2-oxoglutarate + H(+) + L-arginine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689317", "l": "Formation of the pre-incision complex in GG-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67124", "l": "a hydroperoxide + L-cysteinyl-[protein] = an alcohol + S-hydroxy-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2545196", "l": "FN1 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399711", "l": "Activation of Ca impermeable AMPA receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19732", "l": "acetoacetate + H(+) <=> acetone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45731", "l": "(E)-caffeyl alcohol + NADP(+) <=> (E)-caffeyl aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32800", "l": "urea(in) => urea(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63700", "l": "mycophenolate + UDP-alpha-D-glucuronate = mycophenolic acid O-acyl-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61889", "l": "diosgenin + UDP-alpha-D-glucose => diosgenin 3-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30500", "l": "H(+) + N,N-dihydroxy-L-valine => (E)-2-methylpropanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610722", "l": "CK1 phosphorylates p-GLI3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68461", "l": "3'-phosphoadenylyl sulfate + a phenolic steroid => a phenolic steroid 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804425", "l": "TP53 binds POU4F2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690701", "l": "SHP1 binds p-CD22 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351412", "l": "Association of MRE11 and NBS1 leads to nuclear localization of MRN complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67464", "l": "H2O + propanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218906", "l": "RIPK3 phosphorylates MLKL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49605", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) => 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14907", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine => 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30672", "l": "H2O + N,N'-diacetylchitobiose => 2 N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035243", "l": "protein-arginine omega-N symmetric methyltransferase activity", "d": ["Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0005347", "l": "ATP transmembrane transporter activity", "d": ["Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-9717392", "l": "CALHM1:CALHM3 transports ATP from the cytosol to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59977", "l": "2-phenylacetate + H(+) => CO2 + toluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52402", "l": "3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH => 4-O-phospho-D-threonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679028", "l": "JAK3 binds JAK3 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035175", "l": "histone H3S10 kinase activity", "d": ["Catalysis of the reaction: histone H3-serine (position 10) + ATP = histone H3-phosphoserine (position 10) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 10 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5444523", "l": "Formation of MSH1:PMS2 Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8873929", "l": "Casein kinase II phosphorylates STARD10 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17300", "l": "2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15431", "l": "5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine => heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59618", "l": "beta-alanine + L-arginine => beta-alanyl-L-arginine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9623384", "l": "α1-agonists bind ADRA1A,B,D (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047013", "l": "cholate 12-alpha dehydrogenase activity", "d": ["Catalysis of the reaction: cholate + NADP+ = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53632", "l": "(2E,6E)-farnesyl diphosphate = (3S)-(+)-asterisca-2(9),6-diene + diphosphate", "d": []}, {"i": "EC:4.2.3.161", "l": "\"(3S)-(+)-asterisca-2(9),6-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74500", "l": "H(+) + NADPH + yaequinolone D => H2O + NADP(+) + penigequinolone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.216", "l": "\"asperlicin C monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855173", "l": "5-PP-IP4 transports from the nucleus to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9732527", "l": "FFAR1 binds rosiglitazone (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23974", "l": "(2E)-butenoyl-CoA + CO2 + Na(+)(out) => (2E)-glutaconyl-CoA + H(+) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050052", "l": "leukotriene-E4 20-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + leukotriene E(4) + NADPH + O2 = 20-hydroxy-leukotriene E(4) + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69571", "l": "(2S)-2-amino-4-deoxychorismate + H2O + L-glutamine <=> 4-amino-4-deoxychorismate + L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67257", "l": "H2O + NAD(+) + propanal => 2 H(+) + NADH + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64002", "l": "CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30291", "l": "(9Z,12Z)-octadecadienoate + O2 = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}, {"i": "EC:1.13.11.58", "l": "\"linoleate 9S-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17503", "l": "16-epivellosimine + CO2 + methanol => H2O + polyneuridine aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73245", "l": "cirsimaritin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + scutellarein 7-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25156", "l": "(R)-4'-phosphopantothenate + ATP + L-cysteine = AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": []}, {"i": "EC:6.3.2.51", "l": "\"phosphopantothenate--cysteine ligase (ATP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62190", "l": "diphosphate + syn-isopimara-7,15-diene => 9alpha-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4608855", "l": "PRICKLE1 is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62522", "l": "an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20990", "l": "AMP + 2 H(+) + 2 phosphate => ATP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71468", "l": "H2O + substance P => L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72525", "l": "1-hydroxy-6-methoxyphenazine + H(+) + S-adenosyl-L-homocysteine => 1,6-dihydroxyphenazine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29207", "l": "a menaquinol(in) + dimethyl sulfoxide(out) = a menaquinone(in) + dimethyl sulfide(out) + H2O(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20060", "l": "2 H(+) + H2O + N-carbamoylsarcosine <=> CO2 + NH4(+) + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694274", "l": "mRNA1 is translated to pp1ab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14122", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70341", "l": "beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose => alpha-D-Gal-(1->6)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36709", "l": "O-ureido-D-serine => O-ureido-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34376", "l": "4-guanidinobutanamide + H2O => 4-guanidinobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793057", "l": "NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63584", "l": "2-deoxyecdysone 22-phosphate + H2O = 2-deoxyecdysone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111966", "l": "GRK2 binds CALM1:4Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58358", "l": "CO2 + formaldehyde + L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849085", "l": "ARHGAP35 binds RHOA:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56397", "l": "[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9815510", "l": "MIB2 binds CYLD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12764", "l": "precorrin-3B + S-adenosyl-L-methionine <=> 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49235", "l": "D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-mannose 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47622", "l": "2-ethylhexanal + CO2 + H(+) + succinate + sulfate => 2-ethylhexyl sulfate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75862", "l": "Fall Back to Closed Pre-initiation Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57433", "l": "3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] => 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28188", "l": "H2O2 + methylglyoxal + NH4(+) => aminoacetone + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71702", "l": "H(+)(out) + L-phenylalanyl-L-leucine(out) <=> H(+)(in) + L-phenylalanyl-L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69053", "l": "RFC binding displaces Pol Alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801355", "l": "TP53 binds the NLRC4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29767", "l": "ATP + D-methionine(out) + H2O = ADP + D-methionine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23930", "l": "acetate + spermidine => H2O + N(8)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75808", "l": "Na(+)(out) + propanoate(out) => Na(+)(in) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032402", "l": "Activated NTRK2 binds FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72895", "l": "2 acetyl-CoA + 3 H(+) + 6 malonyl-CoA + 2 S-adenosyl-L-methionine = 4-O-demethylbarbatate + 6 CO2 + 8 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50698", "l": "calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247836", "l": "Retromer recycles WLS to the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13242", "l": "ATP + L-fucose => ADP + beta-L-fucose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47139", "l": "ATP + CoA + lithocholate <=> AMP + diphosphate + lithocholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45039", "l": "3 Fe(III)-[cytochrome c] + hydroxylamine <=> 3 Fe(II)-[cytochrome c] + 3 H(+) + nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71952", "l": "3 Na(+)(out) + sulfate(out) => 3 Na(+)(in) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42434", "l": "maleylacetate => 3-hydroxy-cis,cis-muconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848726", "l": "PTK6 phosphorylates BCAR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848751", "l": "PTK6 binds AKT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10474", "l": "propanoate + pyruvate => (2R,3S)-2,3-dimethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39634", "l": "(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH <=> (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655336", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350598", "l": "Arginine<=>Agmatine+CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047169", "l": "galactarate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: feruloyl-CoA + galactarate = 2-(E)-O-feruloyl-D-galactarate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176956", "l": "Formation of GINS complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990915", "l": "structural constituent of ascospore wall", "d": ["The action of a molecule that contributes to the structural integrity of an ascospore wall."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31527", "l": "N(omega)-hydroxy-L-arginine = (S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51037", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 => 2 H2O + indole-3-pyruvate imine dimer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21983", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69005", "l": "Cdc6 protein is phosphorylated by CDK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72671", "l": "eIF5B:GTP is hydrolyzed and released (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50575", "l": "acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033799", "l": "myricetin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + myricetin = S-adenosyl-L-homocysteine + laricitrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3318415", "l": "ATF2 acetylates histone H2B, H4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46917", "l": "H2O + juvenile hormone I => H(+) + juvenile hormone I carboxylate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008747", "l": "N-acetylneuraminate lyase activity", "d": ["Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71652", "l": "a thymidine in DNA + NAD(+) => an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42767", "l": "formate + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> CO2 + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851979", "l": "BTNL9 binds immune cell surfaces (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63833", "l": "(6E)-8-methylnon-6-enoyl-CoA + vanillylamine => capsaicin + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52583", "l": "ATP + H2O + Pb(2+)(in) <=> ADP + H(+) + Pb(2+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944225", "l": "Association of procollagen type XVII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31018", "l": "H(+) + indole-3-carboxylate <=> CO2 + indole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26478", "l": "1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30423", "l": "(2E,6E)-farnesyl diphosphate = (+)-delta-selinene + diphosphate", "d": []}, {"i": "EC:4.2.3.76", "l": "\"(+)-delta-selinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624494", "l": "RAF1 binds p21 RAS:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70839", "l": "L-arginine(in) + L-histidine(out) + Na(+)(out) = L-arginine(out) + L-histidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60424", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + valerianol", "d": []}, {"i": "EC:4.2.3.204", "l": "\"valerianol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40839", "l": "FAD + H(+) + nonanoyl-CoA = (2E)-nonenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32265", "l": "L-alanine + succinate semialdehyde => 4-aminobutanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.34", "l": "\"NEK6-subfamily protein kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52763", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O <=> (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391372", "l": "GNRHR binds GNRH1,2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28546", "l": "alpha-D-glucose = alpha-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676599", "l": "sBAFF trimer binds BAFFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10845", "l": "oxaloacetate + pyridoxamine => L-aspartate + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005292", "l": "high-affinity lysine transmembrane transporter activity", "d": ["Enables the transfer of lysine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21241", "l": "geranylgeranyl diphosphate + L-cysteinyl-[protein] => diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662615", "l": "MT1X binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49396", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35432", "l": "1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside => cyanidin 3,7-di-O-beta-D-glucoside + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139905", "l": "Translocation of activated BAD protein to mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097020", "l": "COPII receptor activity", "d": ["Binding specifically to a substance (cargo) to deliver it to a COPII transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles."]}]}
{"type": "biolink:MolecularActivity", "ic": "75.098124162625822", "identifiers": [{"i": "GO:0019239", "l": "deaminase activity", "d": ["Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799418", "l": "TP53 binds the TP53INP1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140492", "l": "metal-dependent deubiquitinase activity", "d": ["An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37203", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35372", "l": "2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) => (beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57738", "l": "AH2 + all-trans-3,4-didehydroretinol => A + all-trans-3,4-didehydro-13,14-dihydroretinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40011", "l": "(+)-copalyl diphosphate + H2O = diphosphate + manool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54937", "l": "(2E)-decenoyl-[ACP] + H(+) + NADH => decanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610722", "l": "CK1 phosphorylates p-GLI3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10751", "l": "H(+) + hydrogencarbonate <=> CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655193", "l": "KIAA0101 double monoubiquitination (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.3.1", "l": "\"citrate (Si)-synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050066", "l": "lysine 2,3-aminomutase activity", "d": ["Catalysis of the reaction: L-lysine = (3S)-3,6-diaminohexanoate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102003", "l": "Delta8-sphingolipid desaturase activity", "d": ["Catalysis of the reaction: phytosphingosine(1+) + O2 + a reduced electron acceptor <=> 4-hydroxy-trans-8-sphingenine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24006", "l": "(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] => butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976734", "l": "Amyloid fibrils have additional components (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36186", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline <=> a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17299", "l": "CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA => 2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54706", "l": "H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28288", "l": "a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791150", "l": "Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71144", "l": "3-hydroxyhispidin + O2 => (E)-caffeoylpyruvate + CO2 + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28087", "l": "2 H2O2 + Reactive Blue 5 => 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0000257", "l": "nitrilase activity", "d": ["Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31990", "l": "(S)-2,3-epoxysqualene <=> baruol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25735", "l": "L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37403", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010211", "l": "IAA-Leu conjugate hydrolase activity", "d": ["Catalysis of the reaction: indole-3-acetyl-leucine + H2O = indole-3-acetate + L-leucine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53422", "l": "H(+) + roseoflavin + S-adenosyl-L-homocysteine => 8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11461", "l": "ADP + D-glucose => AMP + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72116", "l": "glycine betaine(out) + Na(+)(out) => glycine betaine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35006", "l": "L-fucose(in) <=> L-fucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10992", "l": "glycolate + NADP(+) = glyoxylate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.79", "l": "\"glyoxylate reductase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389463", "l": "Proteinase-activated receptors can bind thrombin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983156", "l": "Polyubiquitination of substrate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20424", "l": "alpha-maltose 6'-phosphate + H2O <=> D-glucose + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17166", "l": "alpha-D-galactose 1-phosphate + dTTP + H(+) => diphosphate + dTDP-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047543", "l": "2-hexadecenal reductase activity", "d": ["Catalysis of the reaction: NADP+ + palmitaldehyde = trans-hexadec-2-enal + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.42", "l": "\"homomethionine N-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55755", "l": "2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34688", "l": "AH2 + N-acyl-15-methylhexadecasphinganine + O2 => A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48827", "l": "GDP-beta-L-fucose + Lc4Cer <=> a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693061", "l": "STAMBP binds STAM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22886", "l": "4-methylsulfanyl-2-oxobutanoate + glycine => glyoxylate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19188", "l": "glyoxylate + H2O + propanoyl-CoA <=> 2-hydroxyglutarate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090591", "l": "protein-N(PI)-phosphohistidine-N-acetyl-mannosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetyl-mannosamine(out) = protein histidine +N-acetyl- mannosamine-6-phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19351", "l": "(R)-3,3-dimethylmalate + 2 H(+) + NADH => (R)-4-dehydropantoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39107", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16662", "l": "fluoride + S-adenosyl-L-methionine => 5'-deoxy-5'-fluoroadenosine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66213", "l": "asc-omegaC5-CoA + O2 => asc-omegaDeltaC5-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399966", "l": "AKT1 E17K mutant phosphorylates GSK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913370", "l": "Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53529", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9732629", "l": "PPARG binds PPARG agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40738", "l": "(20S)-ginsenoside Rb1 + 2 H2O <=> 2 D-glucose + gypenoside LXXV", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57760", "l": "2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928576", "l": "RHOA:GTP binds ROCK, activating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296233", "l": "T2Rs bind bitter-tasting compounds (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67568", "l": "3'-phosphoadenylyl sulfate + taurochenodeoxycholate = adenosine 3',5'-bisphosphate + H(+) + taurochenodeoxycholate 7-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71387", "l": "L-pipecolate(in) + Na(+)(in) = L-pipecolate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675194", "l": "Activated MAPK phosphorylates RAF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50276", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444202", "l": "Receptor FFAR1 binds free fatty acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849435", "l": "PTPN1 dephosphorylates PTK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203977", "l": "SAR1 Activation And Membrane Binding (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35983", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686430", "l": "MUS81 binds EME1, EME2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46975", "l": "A + dihydrobisanhydrobacterioruberin <=> AH2 + bisanhydrobacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1369028", "l": "ABCAs mediate lipid efflux (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41102", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853429", "l": "PHLDA1 binds AURKA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36390", "l": "carbamoyl adenylate + kanamycin A <=> 6''-O-carbamoylkanamycin A + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849857", "l": "KLK5 cleaves and activates CELA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55299", "l": "13-cis-retinol + hexadecanoyl-CoA <=> 13-cis-retinyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033872", "l": "[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18766", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => a 1,2-diacyl-sn-glycerol + a sphingomyelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34266", "l": "dimethylallyl diphosphate + fumigaclavine A <=> diphosphate + fumigaclavine C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52542", "l": "alpha-D-ribose 1-phosphate + cytosine => cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58842", "l": "(24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49268", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.135", "l": "\"1-hydroxy-2-naphthoate hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32836", "l": "4-(trimethylamino)butanoate(in) => 4-(trimethylamino)butanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013435", "l": "RHOD auto-activates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14531", "l": "ADP-D-ribose + phosphate => ADP + D-ribose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16064", "l": "H2O + sn-glycerol 3-phosphocholine <=> choline + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5620975", "l": "MLKL binds PIPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25292", "l": "acetaldehyde + H(+) + NADH => ethanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28918", "l": "4-aminobutanoate(in) + H(+)(in) <=> 4-aminobutanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72868", "l": "3',3',3'-cAAG + H2O => A[3'-5']pG[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047672", "l": "anthranilate N-benzoyltransferase activity", "d": ["Catalysis of the reaction: anthranilate + benzoyl-CoA = N-benzoylanthranilate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51981", "l": "an L-N,N-dihydroxypolyhomomethionine + H(+) => an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050111", "l": "mycocerosate synthase activity", "d": ["Catalysis of the reaction: acyl-CoA + 7n H+ + n methylmalonyl-CoA + 2n NADPH = n CO2 + n CoA + n H2O + multi-methyl-branched acyl-CoA + 2n NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668545", "l": "NIK autophosphorylates on T559 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0047145", "l": "demethylsterigmatocystin 6-O-methyltransferase activity", "d": ["Catalysis of the reaction: 6-demethylsterigmatocystin + S-adenosyl-L-methionine = sterigmatocystin + S-adenosyl-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38729", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952128", "l": "RUNX3 binds TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49074", "l": "dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O => dibenzothiophene + 2 FMNH2 + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57214", "l": "N(2)-(1-hydroxy-2-oxopropyl)-dGTP => dGTP + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55584", "l": "an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.348", "l": "\"mRNA m(6)A methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2029473", "l": "Branching and elongation of mother and daughter filaments (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56647", "l": "a uridine in mRNA <=> a pseudouridine in mRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40970", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165162", "l": "Phosphorylation of TSC2 by PKB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676264", "l": "Formation of the SET1B complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12433", "l": "L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59774", "l": "D-sorbopyranose + H2O2 => D-sorbitol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685345", "l": "Formation of isoAsp (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35258", "l": "ATP + H2O + lipid A-core(in) <=> ADP + H(+) + lipid A-core(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38499", "l": "a triacyl-sn-glycerol + H2O = a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56063", "l": "H(+) + hexadecanoate + hnu <=> CO2 + pentadecane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25798", "l": "4-methylsulfanyl-2-oxobutanoate + L-glutamate => 2-oxoglutarate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10461", "l": "prostaglandin A1 => prostaglandin C1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74191", "l": "carbofuran + H(+) + H2O = 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-ol + CO2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004373", "l": "glycogen (starch) synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205244", "l": "Recruitment of CBL to KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168885", "l": "Haptoglobin binds Hemoglobin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60455", "l": "2-hydroxyethane-1-sulfonate <=> acetaldehyde + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49421", "l": "ATP + valienone => ADP + H(+) + valienone 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22970", "l": "butanoyl-CoA + H(+) + NADH => butanal + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69756", "l": "(2-aminobenzyl)malonyl-CoA + H(+) + O2 => (E)-2-aminocinnamoyl-CoA + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69760", "l": "H2O + NAD(+) + nonanal => 2 H(+) + NADH + nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44513", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58724", "l": "adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15089", "l": "(R)-lactate + A = AH2 + pyruvate", "d": []}, {"i": "EC:1.1.99.6", "l": "\"D-lactate dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68194", "l": "CoA + decanoate phytyl ester => decanoyl-CoA + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682863", "l": "RNF168 binds DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390425", "l": "FAR1 reduces PalmCoA to HXOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432129", "l": "FGR binds and phosphorylates LRP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35618", "l": "hydroxyacetone + NAD(+) <=> H(+) + methylglyoxal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655170", "l": "RCHY1 monoubiquitinates POLH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70481", "l": "TPI1 isomerizes GA3P to DHAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22762", "l": "CO2 + hnu + oxidized Cypridina luciferin => Cypridina luciferin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67879", "l": "3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine <=> 3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0004053", "l": "arginase activity", "d": ["Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177479", "l": "Axonal transport of NGF:Trk complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419334", "l": "Melatonin receptors can bind melatonin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863471", "l": "LDLR is bound by DAB2 and ARH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42605", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0045547", "l": "dehydrodolichyl diphosphate synthase activity", "d": ["Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102770", "l": "inositol phosphorylceramide synthase activity", "d": ["Catalysis of the reaction: an L-1-phosphatidyl-inositol + a dihydroceramide = an inositol phosphodihydroceramide + a 1,2-diacyl-sn-glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371467", "l": "SIRT1 deacetylates HSF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671737", "l": "p-T774-PKN1 binds CDC25C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44445", "l": "a 1,2-diacylglycerol + H2O => a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382096", "l": "Formation of NR-NCOR Corepressor Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16755", "l": "3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+) => Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31344", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50796", "l": "glutathione + prostaglandin A2 = prostaglandin A2-S-(R)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246444", "l": "SLC22A17 binds LCN2:2,5DHBA:Fe3+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035241", "l": "protein-arginine omega-N monomethyltransferase activity", "d": ["Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60902", "l": "an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in RNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47988", "l": "2-dehydro-3-deoxy-L-galactonate + NAD(+) = 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.389", "l": "\"2-dehydro-3-deoxy-L-galactonate 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71734", "l": "citrate(out) + tartrate(in) <=> citrate(in) + tartrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47854", "l": "a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51973", "l": "an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33257", "l": "H(+) + menaquinol-7 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-7 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54442", "l": "a 4-H-anthocyanidin with a 3-hydroxy group + H2O => a (4S)-2,3-dehydroflavan-3,4-diol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57838", "l": "3-aminopropanal + H2O2 + spermidine => H2O + O2 + thermospermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75465", "l": "choline(in) + n H(+)(out) => choline(out) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.7", "l": "\"cholate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75124", "l": "(1R)-(1-hydroxyethyl)phosphonate + O2 => acetate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008523", "l": "sodium-dependent multivitamin transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69059", "l": "H(+) + N(omega)-methyl-L-arginine + NADH + O2 <=> H2O + N(delta)-hydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51630", "l": "CO2 + dUTP + H2O => formate + H(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74733", "l": "Insulin receptor de-phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43371", "l": "dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30791", "l": "dGTP + pyruvate = dGDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.115", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047121", "l": "isoquinoline 1-oxidoreductase activity", "d": ["Catalysis of the reaction: A + H2O + isoquinoline = AH(2) + isoquinolin-1(2H)-one."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210430", "l": "Release of L-Glutamate at the synapse (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013143", "l": "RAC1 GEFs activate RAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74042", "l": "D-alanine(out) + L-alanine(in) <=> D-alanine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37354", "l": "cytidine 2'-phosphate + H2O <=> cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63816", "l": "ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine = AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40187", "l": "(2E)-octenoyl-CoA + H2O = (3R)-hydroxyoctanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983707", "l": "SYK autophosphorylates at the activated BCR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802910", "l": "Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50048", "l": "ATP + cholate(in) + H2O = ADP + cholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11187", "l": "3-(carbamoylamino)propanoate + 2 H(+) + H2O <=> beta-alanine + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203977", "l": "SAR1 Activation And Membrane Binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60485", "l": "CTP + UTP => cyclic CMP-UMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44581", "l": "4-hydroxy-3-all-trans-decaprenylbenzoate + H(+) => 2-all-trans-decaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75160", "l": "NAD(+) + TTP => H(+) + NADP(+) + TDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71622", "l": "(S)-malate(in) + 2 thiosulfate(out) <=> (S)-malate(out) + 2 thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062067", "l": "chloroplast photosystem I binding", "d": ["Binding to a chloroplast photosystem I."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757688", "l": "SERPINA6 binds PREDN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21219", "l": "ATP + D-ribose 5-phosphate <=> ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41046", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18285", "l": "an N-acyl-D-aspartate + H2O = a carboxylate + D-aspartate", "d": []}, {"i": "EC:3.5.1.83", "l": "\"N-acyl-D-aspartate deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380294", "l": "Loss of C-Nap-1 from centrosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58015", "l": "cyclic tetraadenylate <=> 2 5'-hydroxy-diadenylate 2',3'-cylic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102809", "l": "delphinidin 3-O-glucoside 2''-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-beta-D-glucoside <=> H+ + delphinidin 3-O-sophoroside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424485", "l": "Release of p-PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56167", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38632", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47887", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35365", "l": "isopentadecanoyl-CoA + NADP(+) => (2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56827", "l": "AH2 + cyclooctat-9-ene-5,7-diol + O2 <=> A + cyclooctatin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0004169", "l": "dolichyl-phosphate-mannose-protein mannosyltransferase activity", "d": ["Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49320", "l": "all-trans-violaxanthin = (5R,6S)-5,6-epoxi-capsanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938108", "l": "SERPINB13 binds cathepsin L (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65576", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate = an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418456", "l": "cGMP is degraded by PDEs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9022314", "l": "HIPK2 phosphorylates MECP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34779", "l": "a 3alpha-hydroxysteroid + NAD(+) = a 3-oxosteroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10724", "l": "GDP-6-deoxy-alpha-D-talose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11690", "l": "AMP + diphosphate + L-leucyl-tRNA(Leu) => ATP + L-leucine + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050404", "l": "zeatin O-beta-D-xylosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-xylose + zeatin = O-beta-D-xylosylzeatin + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31944", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49473", "l": "trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose => H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58929", "l": "(3R,4R)-7,2',4'-trihydroxyisoflavanol => (6aR,11aR)-3,9-dihydroxypterocarpan + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49846", "l": "(-)-dehydrodiconiferyl acid ketone + a quinol => (-)-dehydrodiconiferyl acid + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0015226", "l": "carnitine transmembrane transporter activity", "d": ["Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468040", "l": "Cohesin binds PDS5 and WAPAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11017", "l": "allantoate + H2O => (S)-ureidoglycolate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341048", "l": "SUMOylation of RXRA with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177284", "l": "PKA phosphorylates PDE4B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662904", "l": "CD isomers transform to BT, BTCA, BZ, ODHBT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22347", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA <=> (R)-rosmarinate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388829", "l": "SHP2 phosphatase binds CTLA-4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20664", "l": "D-alanyl-D-alanine + H2O <=> 2 D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45676", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31808", "l": "(2E,6E)-farnesyl diphosphate => alpha-guaiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183052", "l": "CBL binds to GRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34304", "l": "L-lysine => L-pipecolate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61804", "l": "ATP + H(+) + L-alanine = diphosphate + L-alanyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.31", "l": "\"RBR-type E3 ubiquitin transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2530445", "l": "CD59 inhibits MAC formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50896", "l": "8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O = (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68992", "l": "3-amino-4-hydroxybenzoate + H(+) + NADPH + O2 = 3-amino-2,4-dihydroxybenzoate + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.249", "l": "\"3-amino-4-hydroxybenzoate 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60822", "l": "adenosine 2',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide => H2O + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42978", "l": "2-aminoprop-2-enoate + indole => L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692809", "l": "CDC42 binds effectors at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46683", "l": "2 Fe(III)-[cytochrome b5] + NADH <=> 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693598", "l": "ATM phosphorylates NBN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678843", "l": "ISGylation of protein translation regulator 4EHP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990174", "l": "phosphodiesterase decapping endonuclease activity", "d": ["Catalysis of the removal of the cap from an unmethylated 5'-end capped RNA resulting in the release of the entire cap structure (GpppN) and a 5' monophosphorylated RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080067", "l": "4-methylthiobutyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 4-methylthiobutyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 4-methylthiobutyl-glucosinolate + adenosine 3',5'-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.300", "l": "\"branched-chain beta-ketoacyl-[acyl-carrier-protein] synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3204303", "l": "MRE11 binds cytosolic DNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804527", "l": "INTL1 binds bacterial glycans (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19884", "l": "GTP + L-lysyl-[protein] <=> diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47203", "l": "(24S)-7alpha-dihydroxycholesterol + NAD(+) <=> (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55126", "l": "5-methylhexanoyl-[ACP] + NAD(+) => (2E)-5-methylhexenoyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.42", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40872", "l": "(9Z)-octadecenoyl-CoA + FAD + H(+) => (2E,9Z)-octadecadienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102048", "l": "indole-3-acetyl-isoleucine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-isoleucine + ATP(4-) <=> H+ + indole-3-acetyl-isoleucine + AMP(2-) + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68018", "l": "(2E,6E,10E)-geranylgeraniol + phosphate => (2E,6E,10E)-geranylgeranyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627078", "l": "XIAP binds CASP9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034886", "l": "gamma-aminovinylacetate deaminase activity", "d": ["Catalysis of the reaction: gamma-aminovinylacetate + H2O = succinic semialdehyde + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13056", "l": "L-phenylalanine + pyruvate <=> 3-phenylpyruvate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12820", "l": "2,3-dihydrobiochanin A + NADP(+) <=> biochanin A + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821395", "l": "PAXIP1 binds PAGR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050448", "l": "beta-cyclopiazonate dehydrogenase activity", "d": ["Catalysis of the reaction: beta-cyclopiazonate + A = alpha-cyclopiazonate + AH(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352867", "l": "glucose [cytosol] <=> glucose [extracellular] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202212", "l": "Recruitment of PLC-gamma1 to LAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58393", "l": "4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1606602", "l": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60939", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51401", "l": "octadecanoyl-CoA + serotonin => CoA + H(+) + N-octadecanoyl-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099581", "l": "ATPase coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential", "d": ["Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30381", "l": "(+)-beta-chamigrene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65766", "l": "(2E,4S)-4,5-dihydroxypent-2-enal + a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) => a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21436", "l": "[translation elongation factor 2] + ATP = [translation elongation factor 2]-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.11.20", "l": "\"[elongation factor 2] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.69", "l": "\"gluconate 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18905", "l": "H2O + phosphonoacetaldehyde = acetaldehyde + H(+) + phosphate", "d": []}, {"i": "EC:3.11.1.1", "l": "\"phosphonoacetaldehyde hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266328", "l": "CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63981", "l": "4-thiouridine + ATP => 4-thiouridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010486", "l": "manganese:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Mn2+(in) + H+(out) = Mn2+(out) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432401", "l": "JET binds cytosolic TIM, facilitating its ubiquitination (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36872", "l": "(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140911", "l": "pore-forming activity", "d": ["An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death."]}, {"i": "TCDB:1.C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23494", "l": "UDP-alpha-D-galactosamine => UDP-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114256", "l": "CYCS:APAF1 binds procaspase-9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67560", "l": "3'-phosphoadenylyl sulfate + taurocholate = adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36701", "l": "8-desmethylnovobiocic acid + AMP + diphosphate => 3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213241", "l": "Formation of nonameric complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73965", "l": "aristolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22336", "l": "glycine betaine + L-homocysteine = L-methionine + N,N-dimethylglycine", "d": []}, {"i": "EC:2.1.1.5", "l": "\"betaine--homocysteine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433672", "l": "NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58697", "l": "NADPH + O2 + rifampicin => H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45698", "l": "N-(acetyl)-sphing-4-enine-1-phosphate(out) => N-(acetyl)-sphing-4-enine-1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102738", "l": "(gibberellin-14), 2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A14 + O2 + 2-oxoglutarate <=> gibberellin A37 + carbon dioxide + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665702", "l": "ERBB2 TMD/JMD mutants bind TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68452", "l": "all-trans-10'-apo-beta-carotenal + O2 = 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41497", "l": "1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46822", "l": "4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60355", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone + O2 <=> CO + H(+) + N-octanoylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52753", "l": "H2O + isomaltose => beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647632", "l": "CASP3 cleaves GSDME (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390124", "l": "MATS binds to HPO dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674529", "l": "AAMP binds to TBXA2R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624952", "l": "Assembly of the retrograde IFT train (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182243", "l": "Formation of MHC I:Nef Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028505", "l": "Activated NTRK2 recruits PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14530", "l": "ADP + D-ribose 5-phosphate + H(+) => ADP-D-ribose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858506", "l": "Defective GYS2 does not transfer glucose to growing glycogen chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112434", "l": "Formation of DSIF complex  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032810", "l": "sterol response element binding", "d": ["Binding to a sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72020", "l": "2-oxoglutarate + H(+) + O2 + trihazone A => 2 CO2 + H2O + succinate + trihazone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13090", "l": "6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) => 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34306", "l": "L-lysine <=> L-pipecolate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70337", "l": "2-carboxy-L-lyxonate + H(+) => 2-carboxy-L-lyxonolactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483219", "l": "PC is exchanged with PI by PITPNB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64057", "l": "(1S,2R)-ephedrine + NAD(+) => (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22348", "l": "4-aminoimidazole + H(+) + H2O = imidazol-4-one + NH4(+)", "d": []}, {"i": "EC:3.5.4.8", "l": "\"aminoimidazolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052726", "l": "inositol-1,3,4-trisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50866", "l": "9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9676264", "l": "Formation of the SET1B complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029268", "l": "Phosphorylation and activation of PLCG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43001", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31255", "l": "(2S)-2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018794", "l": "RHOV binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71045", "l": "L-alanine(out) + L-phenylalanine(in) => L-alanine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19253", "l": "a sphingomyelin + H2O = an N-acylsphing-4-enine + H(+) + phosphocholine", "d": []}, {"i": "EC:3.1.4.12", "l": "\"sphingomyelin phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653742", "l": "ATF4 and a CEBP protein bind the ATF5 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42668", "l": "L-rhamnofuranose + NADP(+) = H(+) + L-rhamnono-1,4-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15033", "l": "O2 + pyridoxine = H2O2 + pyridoxal", "d": []}, {"i": "EC:1.1.3.12", "l": "\"pyridoxine 4-oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782381", "l": "PUS1 isoform 2 transforms uridine residues to pseudouridine in the anticodon stems of tRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913360", "l": "GM-CSF receptor alpha subunit binds GM-CSF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855232", "l": "RELN:VLDLR binds DAB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473186", "l": "FSTL3 binds Activin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50515", "l": "acetyl-CoA + N-terminal L-cysteinyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434003", "l": "LPS binding to CD14 co-receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48753", "l": "2-oxoglutarate + O2 + validamycin A => CO2 + H(+) + succinate + validamycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56525", "l": "A + dihydro-heme d1 => AH2 + heme d1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52229", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + biliverdin beta + CO + Fe(2+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50290", "l": "(8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48593", "l": "a quinone + formate + H(+) => a quinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41352", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700149", "l": "Active ALK binds PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21933", "l": "S-adenosyl-L-methionine => L-homoserine lactone + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72795", "l": "bilirubin-bisglucuronoside(out) = bilirubin-bisglucuronoside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71411", "l": "3,3',5-triiodo-L-thyronine(out) + L-tryptophan(in) = 3,3',5-triiodo-L-thyronine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10410", "l": "3-oxopristanoyl-CoA + CoA => 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067640", "l": "IL6 binds IL6R-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613565", "l": "PRKAA2 dissociate from p-PLINs:HSPA8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785524", "l": "Defective C1GALT1C1 does not bind C1GALT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29047", "l": "a menaquinone + 2 H(+)(in) + H2 = a menaquinol + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.27", "l": "\"cathepsin S\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44974", "l": "CoA + O-hexanoyl-(R)-carnitine => (R)-carnitine + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68676", "l": "3'-phosphoadenylyl sulfate + estrone 3-O-(beta-D-glucuronate) = adenosine 3',5'-bisphosphate + estrone 3-O-(3-sulfo-beta-D-glucuronate) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72837", "l": "H(+) + U[3'-5']pAp[3'] => 3',3'-cUAMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17692", "l": "3'-phosphoadenylyl sulfate + glycochenodeoxycholate <=> adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9612509", "l": "SGK phosphorylates SRF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25792", "l": "ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate", "d": []}, {"i": "EC:7.2.2.8", "l": "\"P-type Cu(+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16731", "l": "catechol + H(+) + NADPH => (1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62234", "l": "a thymidine dimer in DNA => a thymidine(6-4)thymidine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2169046", "l": "Degradation of TGF-beta receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55324", "l": "11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788867", "l": "FN3K phosphorylates ketosamines (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63278", "l": "a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37571", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10758", "l": "AMP + diphosphate + H(+) + phosphoenolpyruvate => ATP + phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730847", "l": "Hydrolysis of PIP2 by PLCG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23720", "l": "ATP + hydrogencarbonate + propanoyl-CoA = (S)-methylmalonyl-CoA + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.4.1.3", "l": "\"propionyl-CoA carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69857", "l": "a uridine in mRNA + H(+) + NADPH => a 5,6-dihydrouridine in mRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112437", "l": "Formation of NELF complex  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420274", "l": "GIP receptor binds gastric inhibitory peptide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72523", "l": "1,6-dihydroxyphenazine + S-adenosyl-L-methionine = 1-hydroxy-6-methoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30035", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 = benzene-1,2,4-triol + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20222", "l": "(6S)-5,6,7,8-tetrahydrofolate + ATP + formate => (6S)-10-formyltetrahydrofolate + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052887", "l": "7,9,9'-tricis-neurosporene:quinone oxidoreductase activity", "d": ["Catalysis of the reaction: 7,9,9'-tri-cis-neurosporene + a quinone = 7,9,7',9'-tetra-cis-lycopene + a quinol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052891", "l": "aliphatic (S)-hydroxynitrile lyase activity", "d": ["Catalysis of the reaction: an aliphatic (S)-hydroxynitrile = an aliphatic aldehyde or ketone + cyanide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40308", "l": "A + decanedioyl-CoA => (2E)-decenedioyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814088", "l": "SYS1 binds AcM-ARFRP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0050431", "l": "transforming growth factor beta binding", "d": ["Binding to TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61028", "l": "itaconate + L-cysteinyl-[protein] = S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706837", "l": "AR binds AR antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15714", "l": "a beta-D-galactoside + acetyl-CoA => a 6-acetyl-beta-D-galactoside + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57306", "l": "glycolate + GMP + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983152", "l": "Transfer of ubiquitin from E1 to E2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805059", "l": "CK2:FACT phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374919", "l": "Noradrenaline clearance from the synaptic cleft (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202966", "l": "Caspase mediated cleavage of HIP-55 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44991", "l": "(R)-carnitine + 2-methylpropanoyl-CoA <=> CoA + O-isobutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11165", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.204", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.58", "l": "\"russellysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43130", "l": "H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine => guanosine(10) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68308", "l": "1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40958", "l": "(R)-5-phosphomevalonate + ATP <=> ADP + CO2 + isopentenyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65608", "l": "(4R)-hydroxysphinganine + docosanoyl-CoA = CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9623384", "l": "α1-agonists bind ADRA1A,B,D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38554", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoate + O2 <=> (R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12946", "l": "2'-hydroxybiphenyl-2-sulfinate + H2O => biphenyl-2-ol + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69010", "l": "2-nitrobutanedioate + 4 H2O + 3 NADP(+) => 2 H(+) + L-aspartate + 3 NADPH + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31916", "l": "ATP + D-maltose => ADP + alpha-maltose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71860", "l": "glycochenodeoxycholate(out) => glycochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33288", "l": "A + spermidine => 1-pyrroline + AH2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15810", "l": "(2E)-geranyl diphosphate + H2O => (R)-linalool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51405", "l": "H2O + L-arginine + O2 => 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2993802", "l": "HLCS biotinylates PC:Mn2+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49382", "l": "5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004746", "l": "riboflavin synthase activity", "d": ["Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H+ = 5-amino-6-(D-ribitylamino)uracil + riboflavin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60622", "l": "choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate => N-hexanoyl-sphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22069", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) => (2S)-2-acetolactate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000034", "l": "adenine deaminase activity", "d": ["Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29753", "l": "acetoacetate(out) => acetoacetate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005004", "l": "GPI-linked ephrin receptor activity", "d": ["Combining with a GPI-anchored ephrin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70651", "l": "(9Z)-hexadecenoyl-[ACP] + L-lysyl-[protein] = H(+) + holo-[ACP] + N(6)-[(9Z)-hexadecenoyl]-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54238", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-didecanoyl-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5691131", "l": "CANDI binds CUL1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708457", "l": "HM13 cleaves HMOX1 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.57", "l": "\"O-sialoglycoprotein endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25023", "l": "CDP + FMN + H(+) => CTP + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033941", "l": "mannan exo-1,2-1,6-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of (1->2)-alpha-D- and (1->6)-alpha-D- linkages in mannan, releasing D-mannose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51224", "l": "2 Fe(III)-[cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate = 2 Fe(II)-[cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48190", "l": "(2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein] => (9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54612", "l": "2-oxoglutarate + 3-methylbutanoyl-CoA + O2 = 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69605", "l": "3',5'-cyclic UMP + diphosphate => UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23984", "l": "cholesterol + NADP(+) = 7-dehydrocholesterol + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.21", "l": "\"7-dehydrocholesterol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30281", "l": "3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29989", "l": "adenosine(out) + H(+)(out) => adenosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102137", "l": "7-oxateasterone synthase activity", "d": ["Catalysis of the reaction: H+ + teasterone + NADPH + O2 <=> 7-oxateasterone + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "79.843050782660015", "identifiers": [{"i": "GO:0016743", "l": "carboxyl- or carbamoyltransferase activity", "d": ["Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.1.3.-", "l": "\"Carboxy- and carbamoyltransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46882", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26198", "l": "H2O + melamine => ammeline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61956", "l": "1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606288", "l": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38551", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoate + O2 = (R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46682", "l": "2 Fe(II)-[cytochrome b5] + H(+) + NAD(+) => 2 Fe(III)-[cytochrome b5] + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389350", "l": "Activation of Cdc42 by pVav1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507871", "l": "Aquaporins passively transport glycerol out of cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050402", "l": "xylono-1,4-lactonase activity", "d": ["Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39032", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18127", "l": "a 2-oxocarboxylate + AH2 + NH4(+) => A + a D-alpha-amino acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0001227", "l": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "d": ["A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247922", "l": "GGCT transforms gGluCys to OPRO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48431", "l": "1-(9Z,12Z-octadecadienoyl)-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48422", "l": "CMP + ganglioside GM1 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2660822", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647978", "l": "pro-RAS proteins are farnesylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132264", "l": "Formation of alternate C5 convertase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47291", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48181", "l": "H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45397", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2197690", "l": "Detachment of WASP/WAVE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28418", "l": "(R)-carnitine + 4-(trimethylamino)butanoyl-CoA = (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49905", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786789", "l": "FLT3LG dimer binds FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000137", "l": "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67510", "l": "1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-octadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42014", "l": "11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH => cortisol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47787", "l": "cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853444", "l": "AURKA phosphorylates PHLDA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67120", "l": "N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19000", "l": "CTP + H(+) + phosphocholine <=> CDP-choline + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66081", "l": "2-oxopentanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72973", "l": "5-oxo-L-proline(in) + 2 Na(+)(in) => 5-oxo-L-proline(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781814", "l": "USP19 deubiquitinates RNF123 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17078", "l": "H2O + N,N-dimethylglycine + O2 => formaldehyde + H2O2 + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295599", "l": "SPRY2 translocates to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72457", "l": "fumarate(in) + 3 H(+)(in) => fumarate(out) + 3 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72978", "l": "2 ATP + 2 indole-3-pyruvate <=> 2 AMP + didemethylasterriquinone D + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62085", "l": "ADP + D-glucosamine => AMP + D-glucosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40437", "l": "H(+) + hexadecanoate + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218642", "l": "PTK2 autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31231", "l": "4-acetamidobutanal + H2O + NAD(+) = 4-acetamidobutanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451366", "l": "Activation of p38MAPK by DSCAM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018748", "l": "iprodione amidohydrolase activity", "d": ["Catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12434", "l": "H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine => L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849085", "l": "ARHGAP35 binds RHOA:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-169719", "l": "Secreted CD14 binds LPS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52963", "l": "hyocholate + UDP-alpha-D-glucuronate <=> hyocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190065", "l": "Activated TrkA receptor internalizes to endosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64114", "l": "a fatty acid + L-phenylalanine => an N-acyl-L-phenylalanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42171", "l": "20alpha-hydroxy-5beta-pregnan-3-one + NADP(+) <=> 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29550", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine <=> 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53373", "l": "5,6-dihydrouridine(17) in tRNA + NAD(+) => H(+) + NADH + uridine(17) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20718", "l": "NH4(+) + S-inosyl-L-homocysteine => H(+) + H2O + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14117", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O = [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate", "d": []}, {"i": "EC:3.2.1.67", "l": "\"galacturonan 1,4-alpha-galacturonidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689111", "l": "PARK2 autoubiquitinates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772441", "l": "sFRP binds WNT3A and inhibits WNT:FZD binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31678", "l": "NADP(+) + raucaffrinoline <=> H(+) + NADPH + perakine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033989", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity", "d": ["Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60110", "l": "(E)-4-coumaroyl-CoA + H2O => (R)-3-(4-hydroxyphenyl)lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008811", "l": "chloramphenicol O-acetyltransferase activity", "d": ["Catalysis of the reaction: chloramphenicol + acetyl-CoA = chloramphenicol 3-acetate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65970", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate => 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39565", "l": "(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+) => (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68918", "l": "AMP + butanal + diphosphate + NADP(+) => ATP + butanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296045", "l": "Activation of Potassium transport channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57080", "l": "glutathione + S-methyl-1-thio-D-xylulose 5-phosphate = 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione", "d": []}, {"i": "EC:2.8.4.6", "l": "\"S-methyl-1-thioxylulose 5-phosphate methylthiotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21008", "l": "diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) = diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.229", "l": "\"diethyl 2-methyl-3-oxosuccinate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794830", "l": "SLC22A8 transports Cipro into renal cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802943", "l": "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50122", "l": "CoA + H(+) + N-tetracosanoyl-taurine => taurine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204773", "l": "Interaction of Tie2 and Grb7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25427", "l": "diphosphate + GMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062104", "l": "pumilio-response element binding", "d": ["Binding to a region of RNA containing a Pumilio-response element element. The consensus sequence for the element is UGUAAAUA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193702", "l": "Part of the ICD migrates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19906", "l": "NAD(+) + spermidine => dehydrospermidine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018578", "l": "protocatechuate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090583", "l": "protein-phosphocysteine-D-sorbitol-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-sorbitol(out) = protein cysteine + D-sorbitol-1-phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49917", "l": "(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38440", "l": "(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847977", "l": "FRK phosphorylates PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70179", "l": "2 D-maltotetraose = alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70715", "l": "glycine(in) = glycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-874087", "l": "SGT1 binds HSP90 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717193", "l": "GNB1,3:GNG13 binds PLCB2:Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19470", "l": "NADH + 2 nitric oxide + 2 O2 => H(+) + NAD(+) + 2 nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016990", "l": "arginine deiminase activity", "d": ["Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59811", "l": "L-tyrosine <=> D-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781814", "l": "USP19 deubiquitinates RNF123 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227804", "l": "Inhibition of MDA5-IPS1 signaling by Atg5-Atg12 conjugate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67531", "l": "(6Z)-octenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(6Z-octenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32801", "l": "urea(out) => urea(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26327", "l": "(8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine => (8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25799", "l": "2-oxoglutarate + L-methionine <=> 4-methylsulfanyl-2-oxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71795", "l": "(R)-3-hydroxybutanoate(out) + H(+)(out) = (R)-3-hydroxybutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0016642", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group."]}, {"i": "EC:1.4.4.-", "l": "\"With a disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32391", "l": "(1R,2R,4R)-dihydrocarveol + NAD(+) = (1R,4R)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10134", "l": "AMP + benzoyl-CoA + diphosphate => ATP + benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928619", "l": "PAK1 binds RAC1:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38310", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31841", "l": "dTDP-3-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58399", "l": "4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727607", "l": "MME:Zn2+ binds sacubitrilat (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12558", "l": "6-phospho-D-gluconate + H(+) => 6-phospho-D-glucono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695831", "l": "FLT3 binds type II TKI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944246", "l": "Association of procollagen type XXI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74967", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + H(+) = a (3R)-3-isocyanyl-fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044595", "l": "decaprenyldihydroxybenzoate methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3-decaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-decaprenyl-4-hydroxy-5-methoxybenzoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75348", "l": "thiocyanate(in) => thiocyanate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956568", "l": "RUNX1 binds the core TAL1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5686430", "l": "MUS81 binds EME1, EME2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16843", "l": "H(+) + precorrin-3A + S-adenosyl-L-homocysteine => precorrin-2 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61109", "l": "(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877922", "l": "BGLAP gene expression is stimulated by RUNX2, WWTR1 and RB1 and inhibited by AR, YAP1 and ZNF521 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53977", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74387", "l": "formamide(out) = formamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70766", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382053", "l": "Translocation of PDGF from ER to Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57606", "l": "a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749920", "l": "HEY1,HEY2 bind GATA4,GATA6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25158", "l": "AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => (R)-4'-phosphopantothenate + ATP + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209924", "l": "Dopa is decarboxylated to dopamine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451403", "l": "Interaction of nephrin with adherens junction-associated proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25911", "l": "an alditol + O2 <=> an aldose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57683", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665121", "l": "ERBB2 KD mutants bind TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709317", "l": "CO binds to free ferrohemoglobin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158357", "l": "factor XIIa binds SERPING1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52456", "l": "testosterone + UDP-alpha-D-glucuronate = H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42034", "l": "2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39543", "l": "3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61184", "l": "quercitrin + UDP-beta-L-rhamnose = H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655142", "l": "RCHY1 binds POLH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58506", "l": "(3Z)-2-oxo-4-carboxy-3-hexenedioate => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666008", "l": "SCAI binds SRF:MKL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59528", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71696", "l": "2 H(+)(out) + L-alanyl-L-aspartate(out) => 2 H(+)(in) + L-alanyl-L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45518", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.3.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19887", "l": "(S)-scoulerine + H(+) + H2O2 => (S)-reticuline + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62100", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173725", "l": "C9 binds C5b:C6:C7:C8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668735", "l": "RAC1:GTP binds NOX3 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57105", "l": "[(1->4)-alpha-D-galacturonosyl](n) => 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11390", "l": "an 11-oxosteroid + H(+) + NADPH => an 11beta-hydroxysteroid + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12242", "l": "6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+) => acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043894", "l": "acetyl-CoA synthetase acetyltransferase activity", "d": ["Catalysis of the acetylation of residue Lys609 of the enzyme acetyl-CoA synthetase, using acetyl-CoA as substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52875", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate <=> 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726949", "l": "PTGIR binds PTGIR agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12615", "l": "glutathione disulfide + 2 L-cysteine => 2 glutathione + L-cystine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667619", "l": "AVPR1A,B,2 bind atosiban (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58278", "l": "cyclic hexaadenylate + 6 diphosphate => 6 ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35292", "l": "11-methyldodecanoyl-CoA + H(+) + malonyl-CoA => 3-oxoisopentadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001227", "l": "quercitrin binding", "d": ["Binding to quercitrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619125", "l": "CaMKK phosphorylates CAMK4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57628", "l": "3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate = H2O + ML-236C carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60408", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O = Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6786421", "l": "CHIA hydrolyses chitin (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47591", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E)) <=> CMP + ganglioside GQ1c (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956684", "l": "ITCH polyubiquitinates TP73 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39142", "l": "(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O <=> (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047333", "l": "dihydrostreptomycin-6-phosphate 3'-alpha-kinase activity", "d": ["Catalysis of the reaction: ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:1901981", "l": "phosphatidylinositol phosphate binding", "d": ["Binding to phosphatidylinositol phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654422", "l": "Activated FGFR4 binds FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917841", "l": "Acidification of Tf:TfR1 containing endosome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866277", "l": "AP-2 directly binds some endocytic cargo (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50001", "l": "butane + H(+) + NADH + O2 => butan-1-ol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168638", "l": "Activated IKK phosphorylates I-kappaB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33773", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52720", "l": "5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O = 5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+)", "d": []}, {"i": "EC:2.8.1.15", "l": "\"tRNA-5-methyluridine(54) 2-sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68959", "l": "S-adenosyl-L-methionine + scopoletin <=> H(+) + S-adenosyl-L-homocysteine + scoparone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59259", "l": "Fe(III)-enterobactin + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63030", "l": "(15Z)-tetracosenoate + NH4(+) => (15Z)-tetracosenamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69698", "l": "H(+) + menadione + NADH <=> menadiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944457", "l": "MAF1 translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18172", "l": "4-hydroxy-2-oxoglutarate <=> glyoxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16691", "l": "D-glucose + phosphate => D-glucose 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905576", "l": "ganglioside GT1b binding", "d": ["Binding to ganglioside GT1b."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627078", "l": "XIAP binds CASP9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20181", "l": "alpha-D-mannose derivative + UDP-alpha-D-glucose = 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP", "d": []}, {"i": "EC:2.7.8.19", "l": "\"UDP-glucose--glycoprotein glucose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879221", "l": "PSTPIP1 binds Pyrin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680242", "l": "Ligand-independent dimerization of KIT extracellular domain mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36575", "l": "(9Z)-octadecenoyl-CoA + sphinganine = CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0008331", "l": "high voltage-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193997", "l": "CYP11B1 oxidises 11DCORT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55704", "l": "glycine + hydrogen sulfide + NAD(+) = ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide", "d": []}, {"i": "EC:2.4.2.59", "l": "\"sulfide-dependent adenosine diphosphate thiazole synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9028730", "l": "Activated NTRK2 binds FRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103068", "l": "leukotriene C4 gamma-glutamyl transferase activity", "d": ["Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404144", "l": "Parenchymal atROL translocates to HSCs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34353", "l": "geranate + 2 H(+) + NADH => (2E)-geranial + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299480", "l": "Precursor proteins enter TIMM23 PAM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.78", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983153", "l": "E1 mediated ubiquitin activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56345", "l": "a 7-hydroxyisoflavone + UDP-alpha-D-glucose => a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047481", "l": "D-alanine-alanyl-poly(glycerolphosphate) ligase activity", "d": ["Catalysis of the reaction: alanyl-poly(glycerolphosphate) + D-alanine + ATP = D-alanyl-alanyl-poly(glycerolphosphate) + phosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879322", "l": "mycothione is reduced to mycothiol (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44180", "l": "2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40705", "l": "1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031767", "l": "gastric inhibitory polypeptide receptor binding", "d": ["Binding to a gastric inhibitory polypeptide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56252", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604368", "l": "Autocatalytic activation of bound proMMP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174731", "l": "Degradation of newly synthesized ApoB-48 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052657", "l": "guanine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70554", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73987", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + discoidol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46175", "l": "ATP + butanoate + CoA <=> AMP + butanoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24503", "l": "adenosine 5'-tetraphosphate + H2O <=> ATP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26181", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O => 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50562", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1067667", "l": "IL6 binds IL6R (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730835", "l": "Autophosphorylation of PKC-theta (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9652264", "l": "ERBB2 binds TKIs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54588", "l": "S-adenosyl-L-methionine + uridine in 25S rRNA = H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725023", "l": "NPM-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18079", "l": "H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide => L-arginyl-[dinitrogen reductase] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64121", "l": "an N-(fatty acyl)-L-serine + H2O => a fatty acid + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784959", "l": "BPHL hydrolyses VACV to ACV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004481", "l": "methylene-fatty-acyl-phospholipid synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74662", "l": "N-acetyl-D-glucosamine + UTP <=> H(+) + N-acetyl-D-glucosamine 6-phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54573", "l": "a uridine in tRNA => a pseudouridine in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64562", "l": "butan-2-one + H(+) + NADH => butan-2-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38779", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029272", "l": "Release of PLCG from FCGR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68595", "l": "ORC2 binds ORC3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13095", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP => an N-acylsphing-4-enine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34992", "l": "L-arginine(out) + L-ornithine(in) => L-arginine(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35214", "l": "dIDP + H2O <=> dIMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23592", "l": "glycerol + NADP(+) = D-glyceraldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190261", "l": "FGFR3c binds to FGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73596", "l": "dCMP + H2O => dUMP + NH4+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15209", "l": "(2R,3R)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0061542", "l": "3-demethylubiquinol-n 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-n = S-adenosyl-L-homocysteine + ubiquinol-n."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70375", "l": "3-oxosphinganine + dodecanoyl-CoA = CoA + H(+) + N-dodecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14300", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O <=> an N-acylsphing-4-enine + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507875", "l": "Aquaporins passively transport urea into cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093332", "l": "p-EPHB phosphorylates SDC2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18321", "l": "2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31977", "l": "7beta-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + taxusin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939204", "l": "ESTG binds ESR1:chaperone complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57425", "l": "guaiacol + O2 + reduced [NADH--hemoprotein reductase] => catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19522", "l": "acetyl-CoA + phosphate => acetyl phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111237", "l": "Formation of ADAR1 homodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17380", "l": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] <=> 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0019172", "l": "glyoxalase III activity", "d": ["Catalysis of the reaction: methylglyoxal + H2O = D-lactate."]}]}
{"type": "biolink:MolecularActivity", "ic": "67.572744119402742", "identifiers": [{"i": "GO:0016645", "l": "oxidoreductase activity, acting on the CH-NH group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}, {"i": "EC:1.5.-.-", "l": "\"Acting on the CH-NH group of donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420975", "l": "Ca impermeable AMPA receptor ligand binding (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696275", "l": "RND2 binds GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9732629", "l": "PPARG binds PPARG agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62002", "l": "3 AH2 + protoporphyrin IX => 3 A + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22537", "l": "(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine => (S)-tetrahydropalmatine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13277", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate = [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.29", "l": "\"cyanophycin synthase (L-aspartate-adding)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57600", "l": "a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211191", "l": "Association of DFF with alpha:beta importin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69855", "l": "a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0015603", "l": "iron chelate transmembrane transporter activity", "d": ["Enables the transfer of an iron chelate from one side of a membrane to the other. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050141", "l": "nitroethane oxidase activity", "d": ["Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + nitrite + H2O2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047942", "l": "glutamate-ethylamine ligase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP + ethylamine = N(5)-ethyl-L-glutamine + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791123", "l": "Expression of KDELR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37224", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944457", "l": "MAF1 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58968", "l": "1-naphthaldehyde + H2O + O2 = 1-naphthoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47137", "l": "ATP + CoA + lithocholate => AMP + diphosphate + lithocholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399711", "l": "Activation of Ca impermeable AMPA receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23580", "l": "prostaglandin H2 = prostaglandin I2", "d": []}, {"i": "EC:5.3.99.4", "l": "\"prostaglandin-I synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50365", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63554", "l": "angiotensin-(1-5) + L-histidyl-L-proline => angiotensin-(1-7) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654573", "l": "Activated FGFR1 binds SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10398", "l": "a 2-oxocarboxylate + H(+) + NADH + NH4(+) => an L-alpha-amino acid + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41077", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39191", "l": "(2E)-docosenoyl-CoA + H(+) + NADPH = docosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052904", "l": "N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity", "d": ["Catalysis of the reaction: H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102043", "l": "isopentenyl phosphate kinase activity", "d": ["Catalysis of the reaction: isopentenyl phosphate(2-) + ATP(4-) <=> isopentenyl diphosphate(3-) + ADP(3-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70810", "l": "4-deoxy-4-sulfo-D-erythrose <=> 4-deoxy-4-sulfo-D-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11790", "l": "H(+) + NADH + NH4(+) + oxaloacetate => H2O + L-aspartate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9669893", "l": "KIT binds type I TKIs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022065", "l": "DSPGs are secreted (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9654533", "l": "KRAS4B recycles to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950778", "l": "p-Y693-STAT4 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12334", "l": "ADP + Fe(3+)(in) + H(+) + phosphate => ATP + Fe(3+)(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71015", "l": "H2O + N-methylputrescine + O2 = 4-methylaminobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114256", "l": "CYCS:APAF1 binds procaspase-9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50607", "l": "acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849908", "l": "SALM4 binds flotillin-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64814", "l": "CoA + H(+) + S-(2-acetamidoethyl)-homocysteine => acetyl-CoA + S-(2-aminoethyl)-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19863", "l": "a 16-oxosteroid + H(+) + NADH => a 16alpha-hydroxysteroid + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046538", "l": "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity", "d": ["Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; this reaction mechanism uses 2,3-bisphosphoglycerate as a phosphate donor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56951", "l": "pyruvate + UTP <=> H(+) + phosphoenolpyruvate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51611", "l": "(R)-2-hydroxyglutarate + pyruvate <=> (R)-lactate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37482", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18667", "l": "(2R)-3-phosphoglycerate + [phosphate](n+1) => (2R)-3-phospho-glyceroyl phosphate + [phosphate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23187", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate <=> (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29557", "l": "alpha-D-glucose 1-phosphate + 2 H(+) + UMP => H2O + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0031151", "l": "histone H3K79 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group to the lysine residue at position 79 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-166214", "l": "FA anion flip-flops to the opposite surface (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16511", "l": "CO2 + formate => H(+) + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374916", "l": "Re-acidification of clathrin sculpted monoamine transport vesicle lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39225", "l": "(2E)-octacosenoyl-CoA + H2O => (3R)-hydroxyoctacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38148", "l": "carbon disulfide + H2O => carbonyl sulfide + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951676", "l": "RUNX3 binds TEADs and YAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14147", "l": "ADP + H(+) + phosphoguanidinoacetate => ATP + guanidinoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24978", "l": "(1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15883", "l": "ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein] => ATP + L-seryl-[Fas-activated protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29680", "l": "formate(in) => formate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163625", "l": "Glucagon binds to Glucagon receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58693", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV => FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63663", "l": "(8S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein] <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63015", "l": "(2E,6E)-farnesyl diphosphate + orsellinate <=> diphosphate + ilicicolinate B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19492", "l": "dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide <=> 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857555", "l": "EGFR phosphorylates GPNMB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14933", "l": "H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] = N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211164", "l": "AKT phosphorylates FOXO1A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24566", "l": "a 3-oxoacyl-CoA + succinate => a 3-oxo acid + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388811", "l": "CD28 homodimer binds B7-1 homodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734730", "l": "ORC1 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070226", "l": "sulfur:ferric ion oxidoreductase activity", "d": ["Catalysis of the reaction: a perthiol + 4 Fe3+ + 3 H2O = sulfite + a thiol + 4 Fe2+ + 8 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202726", "l": "F11R dimerises (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043750", "l": "phosphatidylinositol alpha-mannosyltransferase activity", "d": ["Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429441", "l": "SYK activation by SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086037", "l": "P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in), that contributes to regulating the membrane potential of a cardiac muscle cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432148", "l": "Fgr may phosphorylate p38 MAPK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354060", "l": "Translocation of RIAM to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22964", "l": "H(+) + L-ornithine = CO2 + putrescine", "d": []}, {"i": "EC:4.1.1.17", "l": "\"ornithine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60454", "l": "acetaldehyde + H(+) + sulfite => 2-hydroxyethane-1-sulfonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47239", "l": "eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700120", "l": "PTN and MDK bind to PTPRZ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357445", "l": "PAK1-3 dimer disassociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43397", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33075", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine = 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine", "d": []}, {"i": "EC:2.5.1.120", "l": "\"aminodeoxyfutalosine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.545697013636541", "identifiers": [{"i": "GO:0015108", "l": "chloride transmembrane transporter activity", "d": ["Enables the transfer of chloride ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948027", "l": "RNASEs bind bacterial phospholipids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602454", "l": "proMMP9 binds TIMP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944227", "l": "Association of procollagen type XXII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73183", "l": "ADP(in) + FAD(out) = ADP(out) + FAD(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34531", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": []}, {"i": "EC:2.3.1.209", "l": "\"dTDP-4-amino-4,6-dideoxy-D-glucose acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68611", "l": "Formation of ORC(1-5) complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938913", "l": "RUNX1 binds ELF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202127", "l": "eNOS synthesizes NO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51885", "l": "L-proline betaine => D-proline betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8987007", "l": "p-STAT1 dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350604", "l": "Agmatine + H2O <=> putrescine + urea (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693561", "l": "RAD51 binds BRCA2 at resected DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879222", "l": "MDP:NLRP1 binds ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45852", "l": "Co(II)-factor III + H(+) + S-adenosyl-L-methionine = Co(II)-factor IV + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75041", "l": "acetyl-CoA(out) => acetyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35589", "l": "phosphate + riboflavin => FMN + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30043", "l": "fumarate + L-aspartate = iminosuccinate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951499", "l": "Loading of antigenic peptides on to class I MHC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693783", "l": "NAALADases hydrolyse NAAG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034010", "l": "sulfolactate sulfo-lyase activity", "d": ["Catalysis of the reaction: 3-sulfolactate = pyruvate + sulfite."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016162", "l": "cellulose 1,4-beta-cellobiosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67735", "l": "uridylyl-uridylyl-ribonucleotide-RNA <=> a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610752", "l": "GLI3R translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625482", "l": "PTK2 binds activated EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61179", "l": "(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside <=> CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209215", "l": "CI activates transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19262", "l": "ATP + H2O + heme b(in) => ADP + H(+) + heme b(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710917", "l": "ALK fusion proteins bind PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15043", "l": "inulobiose => bis-D-fructose 2',1:2,1'-dianhydride + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661517", "l": "LUBAC binds OTULIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800315", "l": "MST1 binds MST1R (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785565", "l": "Defective B3GALTL does not transfer glucose to O-fucosyl-proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15268", "l": "1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate <=> H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70326", "l": "2,3-dioxo-L-gulonate <=> 2-carboxy-L-lyxonolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "61.085121200529862", "identifiers": [{"i": "GO:0017111", "l": "ribonucleoside triphosphate phosphatase activity", "d": ["Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72630", "l": "2 H(+)(out) + Zn(2+)(in) <=> 2 H(+)(in) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14357", "l": "ATP + riboflavin = ADP + FMN + H(+)", "d": []}, {"i": "EC:2.7.1.26", "l": "\"riboflavin kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25693", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) <=> CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784204", "l": "JAKs bind OSMR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36120", "l": "gibberellin A9 + S-adenosyl-L-methionine => O-methyl gibberellin A9 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953111", "l": "E2F6 binds TFDP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871227", "l": "RET binds GFRA4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27662", "l": "(S)-2-hydroxyglutarate + O2 = 2-oxoglutarate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797100", "l": "CCNK binds CDK13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53156", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48398", "l": "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine => (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373747", "l": "Phosphorylation of nephrin by FYN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22877", "l": "(R)-mandelamide + H2O => (R)-mandelate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198756", "l": "ERK1/2 phosphorylates MSK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097265", "l": "5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity", "d": ["Catalysis of the reaction: 5-HETE + NADP+ = 5-oxo-ETE + NADPH + H+."]}, {"i": "REACT:R-HSA-2161776", "l": "5S-HETE is oxidised to 5-oxoETE by 5-HEDH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58990", "l": "(E)-4-hydroxynon-2-enoate + H(+) + H2O2 => (E)-4-hydroxynon-2-enal + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678998", "l": "Endosomal TLRs pass through the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69367", "l": "6-diazo-5-oxo-L-norleucine + acetyl-CoA <=> CoA + H(+) + N(alpha)-acetyl-6-diazo-5-oxo-L-norleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036393", "l": "thiocyanate peroxidase activity", "d": ["Catalysis of the reaction: thiocyanate (SCN-) + hydrogen peroxide (H2O2) = hypothiocyanite (OSCN-) + 2 H2O. Catalyzes the hydrogen peroxide oxidation of thiocyanate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099520", "l": "monoatomic ion antiporter activity involved in regulation of presynaptic membrane potential", "d": ["Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60293", "l": "L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26404", "l": "all-trans-10'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11171", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) <=> 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693783", "l": "NAALADases hydrolyse NAAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170796", "l": "NPC transports GCK1:GKRP from cytosol to nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4332235", "l": "CBL binds TGFBR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004849", "l": "uridine kinase activity", "d": ["Catalysis of the reaction: ATP + uridine = ADP + UMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18508", "l": "L-lysine + NAD(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102286", "l": "ornithine N-delta-acetyltransferase activity", "d": ["Catalysis of the reaction: L-ornithinium(1+) = N(5)-acetyl-L-ornithine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64855", "l": "benzoyl-CoA + octan-1-ol <=> CoA + octyl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694294", "l": "E pentamer is transported to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106432", "l": "queuosine nucleosidase activity", "d": ["Catalysis of the reaction: a N-D-queuosine + H2O = queuine + D-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70027", "l": "N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237119", "l": "Acireductone is oxidized to MOB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20074", "l": "D-allothreonine => acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863463", "l": "STON2 binds SYT proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63063", "l": "5-methylorsellinate + ATP + H(+) + NADPH <=> 2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614614", "l": "Cysteine is degraded to serine and H2S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32078", "l": "geranylgeranyl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004463", "l": "leukotriene-A4 hydrolase activity", "d": ["Catalysis of the reaction: H2O + leukotriene A(4) = leukotriene B(4)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047363", "l": "triglucosylalkylacylglycerol sulfotransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + 3'-phosphoadenosine 5'-phosphosulfate = 6-sulfo-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + adenosine 3',5'-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694287", "l": "Cleavage of S protein into S1:S2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41142", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67514", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11353", "l": "acetate + ATP => acetyl phosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420131", "l": "The PACAP receptor binds PACAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64541", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51092", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.127", "l": "\"jasmonoyl-L-amino acid hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37092", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63539", "l": "bradykinin(1-8) + H2O <=> bradykinin(1-7) + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58555", "l": "15alpha-stemmadenine intermediate II + H2O <=> (16R)-deshydroxymethyl-stemmadenine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43461", "l": "dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45185", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+) => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050416", "l": "formimidoylglutamate deiminase activity", "d": ["Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009309", "l": "RUNX2 binds STUB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852010", "l": "BTNL2 binds activated T cells surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22308", "l": "O2 + xylitol = D-xylose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5444516", "l": "Formation of MSH2:MSH6 Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.151", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10210", "l": "H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg) => an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52205", "l": "butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70546", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[protein] + UDP-alpha-D-glucose <=> 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74185", "l": "H(+) + S-adenosyl-L-homocysteine + taxifolin 4'-methyl ether => S-adenosyl-L-methionine + taxifolin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16376", "l": "(R)-pantothenate + ATP <=> (R)-4'-phosphopantothenate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334164", "l": "DNMT3B:DNMT3L binds chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004381", "l": "fucosylgalactoside 3-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61363", "l": "ATP + H2O + pheophorbide a(in) <=> ADP + H(+) + pheophorbide a(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416929", "l": "PTGFR binds PGF2a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44205", "l": "2-hydroxyhexadecanoate + ATP + CoA => 2-hydroxyhexadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16375", "l": "(R)-4'-phosphopantothenate + ADP + H(+) => (R)-pantothenate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850831", "l": "KLK5 cleaves and activates KLK8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60725", "l": "dodecanal + H2O + NADP(+) => dodecanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103061", "l": "trans-methoxy-C60-meroacyl-AMP ligase activity", "d": ["Catalysis of the reaction: ATP(4-) + H2O + a trans-methoxy-C60-meroacyl-[acp] <=> diphosphoric acid + a trans-methoxy-meroacyl-adenylate + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55173", "l": "2-oxoglutarate + hexanoyl-CoA + O2 => 2-hydroxyhexanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31335", "l": "CTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin cytosine dinucleotide", "d": []}, {"i": "EC:2.7.7.76", "l": "\"molybdenum cofactor cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57123", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58106", "l": "(14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678925", "l": "NR3C1 binds NR3C1 agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47736", "l": "cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357472", "l": "PAK1-3 autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390909", "l": "HRH2 binds hist (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19910", "l": "(S)-lactate + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645598", "l": "RRAGC,D hydrolyzes GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140416", "l": "transcription regulator inhibitor activity", "d": ["A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75462", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20490", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) => 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53017", "l": "chlorohydroquinone + 2 glutathione => chloride + glutathione disulfide + H(+) + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687458", "l": "HSV1 RIR1 binds CASP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22660", "l": "a fatty acid + ATP + holo-[ACP] = a fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65466", "l": "2-methylbutyl butanoate + CoA => 2-methylbutan-1-ol + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.115", "l": "\"branched-dextran exo-1,2-alpha-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388832", "l": "PI3K binds CD28 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200406", "l": "CPT1A,B transfers PALM to CAR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65036", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69317", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate => allyl thiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14812", "l": "phenol + S-adenosyl-L-methionine <=> anisole + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75167", "l": "CTP + NAD(+) = CDP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5138459", "l": "WNT5A:FZD4 is endocytosed (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52276", "l": "(6S)-5,6,7,8-tetrahydrofolate + vanillate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9676268", "l": "Formation of the MLL4 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664397", "l": "IgG binds LPG1G2 in the amastigote form of Leishmania (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32604", "l": "(6E)-8-hydroxygeraniol + NADP(+) => (6E)-8-oxogeraniol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51366", "l": "CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54606", "l": "2-hydroxydecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + decanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74564", "l": "aldosterone hemiacetal + UDP-alpha-D-glucuronate => aldosterone hemiacetal 18-beta-glucuronide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333612", "l": "MeSebGalNac is oxidatively cleaved to MeSeO2H and 2-acetamidoglucal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645535", "l": "ALPK1 phosphorylates TIFA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13310", "l": "H2O + NAD(+) + vanillin => 2 H(+) + NADH + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60644", "l": "3'-phosphoadenylyl sulfate + androsterone = adenosine 3',5'-bisphosphate + androsterone 3alpha-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36221", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27702", "l": "aldehydo-D-galacturonate = keto-D-tagaturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48811", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.1", "l": "\"phosphodiesterase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12097", "l": "H2O + N-benzylformamide => benzylamine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50168", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25081", "l": "(2S)-2-isopropyl-3-oxosuccinate + H(+) <=> 4-methyl-2-oxopentanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51573", "l": "(25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186798", "l": "GAP binds to PDGF-beta receptors only (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55824", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide d = a bacteriochlorophyllide f + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251992", "l": "Cleavage of P-ERBB4jmA isoforms by ADAM17 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68601", "l": "(2S)-3-sulfopropanediol => 3-oxopropane-1-sulfonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59169", "l": "ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate => AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19957", "l": "2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465924", "l": "OPN1LW binds 11cRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674095", "l": "PDGFRs bind type II TKI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098618", "l": "selenomethionine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-selenomethionine + tRNA(Met) => AMP + diphosphate + selenomethionyl-tRNA(Met)."]}, {"i": "REACT:R-HSA-2408546", "l": "tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50954", "l": "A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin => 7-chloro-L-tryptophan + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26324", "l": "resorcinol + S-adenosyl-L-methionine <=> 3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60087", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) <=> a 4alpha-methyl-3-oxosteroid + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784959", "l": "BPHL hydrolyses VACV to ACV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65031", "l": "(+)-pinoresinol + H2O + 2 oxidized [azurin] <=> (+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0005031", "l": "tumor necrosis factor receptor activity", "d": ["Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694528", "l": "Accessory proteins are recruited to the maturing virion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190245", "l": "FGFR1b binds to FGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9650165", "l": "ASIC trimers bind H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28194", "l": "(2S)-3-sulfolactate + NAD(+) = 3-sulfopyruvate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.310", "l": "\"(S)-sulfolactate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61057", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483107", "l": "GPETA is hydrolyzed to ETA and G3P by GPCPD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450074", "l": "Interleukin-3 receptor alpha subunit binds Interleukin-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17138", "l": "prostaglandin H2 => thromboxane A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60566", "l": "2-deoxy-D-glucose 6-phosphate + ADP + H(+) => 2-deoxy-D-glucose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10221", "l": "ATP + L-tyrosine + tRNA(Tyr) => AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18847", "l": "2-hydroxy-3-oxopropanoate + H(+) + NADH => (R)-glycerate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710353", "l": "GSDMD (1-275) binds cardiolipin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2025890", "l": "Calcineurin binds NFATC1,2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375160", "l": "NCAM1 binds to ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48348", "l": "a uridine in RNA = a pseudouridine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648268", "l": "HTR1A binds HTR1A antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22720", "l": "ATP + L-histidyl-[protein] = ADP + H(+) + N(pros)-phospho-L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.13.1", "l": "\"protein-histidine pros-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3221982", "l": "BANP binds TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46335", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63664", "l": "(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH = H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74948", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2-oxoglutarate + O2 => (3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43610", "l": "2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate => agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39748", "l": "cholesterol(in) => cholesterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0008391", "l": "arachidonic acid monooxygenase activity", "d": ["Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785245", "l": "Defective CYP11B2 does not oxidise CORST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9718379", "l": "GNRHR binds chemical antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41791", "l": "acetyl-CoA + holo-[ACP] <=> acetyl-[ACP] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696267", "l": "RND3 binds GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69514", "l": "H(+) + H2O2 + N-acetyl-D-galactosaminate => H2O + N-acetyl-D-galactosamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53489", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH => 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632668", "l": "SMO translocates to the cilium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12241", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH => 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40579", "l": "1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54691", "l": "alliin <=> 2-aminoprop-2-enoate + allylsulfenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793819", "l": "HSF1 trimer binds HSE on the target gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39315", "l": "(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA = (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42872", "l": "N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76109", "l": "(11R)-hydroxymethyl carlactonoate + CO2 + succinate => (11R)-methyl carlactonoate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66312", "l": "an alpha-mannosylinositol-1-phosphoceramide + H2O = a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61125", "l": "kaempferol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110159", "l": "TDG glycosylase mediated recognition and binding of an uracil opposite to a guanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33701", "l": "(4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O => C20 sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20040", "l": "D-sorbitol 6-phosphate + NADP(+) <=> aldehydo-D-glucose 6-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68635", "l": "3 H(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49861", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41396", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine = 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64707", "l": "diphenylmethanol + NAD(+) <=> benzophenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27441", "l": "NAD(+) + xylitol = D-xylose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388832", "l": "PI3K binds CD28 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38087", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375151", "l": "Interaction of NCAM1 with collagens (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865320", "l": "CBFB binds RUNX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n6", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018645", "l": "alkene monooxygenase activity", "d": ["Catalysis of the reaction: propene + NADH + H+ + O2 = 1,2-epoxypropane + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708557", "l": "FBXL17 binds BACH1:MAFK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37145", "l": "1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12446", "l": "(2E)-hexadecenal + H(+) + NADPH => hexadecanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139909", "l": "Translocation of BMF to mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21201", "l": "2-oxoglutarate + L-lysine => (S)-2-amino-6-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25794", "l": "ADP + Cu(+)(out) + H(+) + phosphate => ATP + Cu(+)(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000405", "l": "bubble DNA binding", "d": ["Binding to DNA segment that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63555", "l": "angiotensin-(1-7) + H2O <=> angiotensin-(1-5) + L-histidyl-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16866", "l": "choloyl-CoA + propanoyl-CoA => 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112430", "l": "Formation of P-TEFb complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45491", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102779", "l": "cannabidiolate synthase activity", "d": ["Catalysis of the reaction: cannabigerolate + O2 <=> cannabidiolate + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56386", "l": "(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800253", "l": "TP53 binds the BCL6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664867", "l": "NBR1 binds MAP1LC3B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13066", "l": "ATP + H2O => ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25117", "l": "H2O + L-lysine + NAD(+) = (S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821412", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51582", "l": "a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695964", "l": "ABHD14B hydrolyses PNPB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54357", "l": "3-methyl-2-oxobutanoate + H(+) => 2-methylpropanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0009381", "l": "excinuclease ABC activity", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-901047", "l": "Binding of ERp57 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69365", "l": "6-diazo-5-oxo-L-norleucine + acetyl-CoA => CoA + H(+) + N(alpha)-acetyl-6-diazo-5-oxo-L-norleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54723", "l": "N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102701", "l": "tricyclene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate(3-) <=> tricyclene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53845", "l": "glycochenodeoxycholate + NAD(+) => 7-oxoglycolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49404", "l": "beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate = alpha-D-mannose 1-phosphate + D-mannose", "d": []}, {"i": "EC:2.4.1.339", "l": "\"beta-1,2-mannobiose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45106", "l": "mitomycin A + S-adenosyl-L-homocysteine => 6-demethylmitomycin A + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36901", "l": "H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine => guanosine(37) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66710", "l": "2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13569", "l": "ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.165", "l": "\"N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420977", "l": "Ca permeable AMPA receptor ligand binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62315", "l": "salicylate + UDP-alpha-D-glucose <=> H(+) + salicylate 2-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57898", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73577", "l": "CAD hexamer transforms L-Gln to CAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36533", "l": "(15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA => (13Z)-docosenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17772", "l": "choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10067", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62526", "l": "H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine => cytidine(839) in 12S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.51", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0019912", "l": "cyclin-dependent protein kinase activating kinase activity", "d": ["Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210300", "l": "Interaction of DAP12 and TREM2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45001", "l": "(R)-carnitine + 3-hydroxybutanoyl-CoA => CoA + O-3-hydroxybutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:1990888", "l": "2-polyprenyl-6-hydroxyphenol O-methyltransferase activity", "d": ["Catalysis of the reaction: 2-polyprenyl-6-hydroxyphenol + S-adenosyl-L-methionine = 2-polyprenyl-6-methoxyphenol + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55326", "l": "11-cis-retinyl hexadecanoate + CoA => 11-cis-retinol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58164", "l": "(2E,6E)-farnesyl diphosphate + 2 H2O = 7-epi-ent-eudesmane-5,11-diol + diphosphate", "d": []}, {"i": "EC:4.2.3.197", "l": "\"eudesmane-5,11-diol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200646", "l": "Cytosolic folate export across the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71227", "l": "2 Na(+)(out) + selenocyanate(out) = 2 Na(+)(in) + selenocyanate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388831", "l": "Phosphorylation of CD28 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72286", "l": "a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) <=> a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0004016", "l": "adenylate cyclase activity", "d": ["Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848606", "l": "PTK6 phosphorylates PXN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987039", "l": "JAK1 binds IL20RA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53778", "l": "3-sulfinopropanoate + H(+) => 3-sulfanylpropanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42167", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 <=> (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69152", "l": "Removal of remaining Flap (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21012", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}, {"i": "EC:2.4.1.70", "l": "\"poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033451", "l": "GUA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GUA codon."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047408", "l": "alkenylglycerophosphocholine hydrolase activity", "d": ["Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102633", "l": "flaviolin monooxygenase activity", "d": ["Catalysis of the reaction: flaviolin-2-olate + NADH + H+ + O2 <=> mompain + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58691", "l": "NADH + O2 + rifamycin SV <=> H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789185", "l": "Chloride ion and N-acyl group react to chloramide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018664", "l": "benzoate 4-monooxygenase activity", "d": ["Catalysis of the reaction: benzoate + H+ + NADPH + O2 = 4-hydroxybenzoate + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-593685", "l": "Netrin-4 binds DCC/UNC5A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73867", "l": "serotonin(out) = serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70733", "l": "4-aminobutanoate(in) + chloride(in) + 3 Na(+)(in) => 4-aminobutanoate(out) + chloride(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017020", "l": "myosin phosphatase regulator activity", "d": ["Binds to and modulates of the activity of myosin phosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026001", "l": "Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509827", "l": "ITPA hydrolyses ITP to IMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12908", "l": "alpha-D-mannose 1-phosphate + GDP + H(+) <=> GDP-alpha-D-mannose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627056", "l": "Procaspase 9 forms dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35012", "l": "D-fucose(in) + H(+)(in) => D-fucose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74644", "l": "CMP-N-acetyl-beta-neuraminate(in) + UMP(out) => CMP-N-acetyl-beta-neuraminate(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50679", "l": "H(+) + H2O + N-terminal L-asparaginyl-[protein] <=> N-terminal L-aspartyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31741", "l": "a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine => a 4'-hydroxyisoflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050333", "l": "thiamine triphosphate phosphatase activity", "d": ["Catalysis of the reaction: H2O + thiamine triphosphate = thiamine diphosphate + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759859", "l": "Expression of GATA4 in lateral plate mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35511", "l": "glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] = glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33743", "l": "an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112690", "l": "PTPN11 binds CBL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9795153", "l": "Basolateral excretion of oxo-Cipro (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60377", "l": "D-glucose(out) => D-glucose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60560", "l": "L-methionyl-[protein] + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.3.17", "l": "\"guanidinopropionase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67118", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656070", "l": "FGFBPs bind FGFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762345", "l": "PREDN:ALB dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36651", "l": "8-desmethylnovobiocic acid + S-adenosyl-L-methionine = H(+) + novobiocic acid + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.284", "l": "\"8-demethylnovobiocic acid C(8)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.16", "l": "\"oxazoline dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625674", "l": "Defective SLC22A5 does not cotransport CAR, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36472", "l": "3,4,5-trihydroxybenzoate(out) + H(+)(out) => 3,4,5-trihydroxybenzoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236972", "l": "Escape of antigens from phagosome to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67558", "l": "adenosine 3',5'-bisphosphate + glycocholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + glycocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30277", "l": "A + 2 H2O => AH2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51319", "l": "(9Z)-octadecenoate + glycine <=> H2O + N-(9Z-octadecenoyl)glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24144", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.57", "l": "\"isohexenylglutaconyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953013", "l": "E2F7 binds E2F8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990259", "l": "histone H2AQ104 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-glutamine (position 104) = S-adenosyl-L-homocysteine + (histone H2A)-N5-methyl-glutamine (position 104). Note that this corresponds to  Q105 in yeast."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004575", "l": "sucrose alpha-glucosidase activity", "d": ["Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033994", "l": "glucuronan lyase activity", "d": ["Catalysis of the reaction: (1->4)-beta-D-glucuronan = an oligosaccharide with 4-deoxy-beta-D-gluc-4-enuronosyl end + (1->4)-beta-D-glucuronan. This reaction is the eliminative cleavage of (1->4)-beta-D-glucuronans to give oligosaccharides with 4-deoxy-beta-D-gluc-4-enuronosyl groups at their non-reducing ends. Complete degradation of glucuronans results in the formation of tetrasaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050624", "l": "vomilenine reductase activity", "d": ["Catalysis of the reaction: 1,2-dihydrovomilenine + NADP+ = H+ + NADPH + vomilenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877361", "l": "Pyrin binds ASC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30339", "l": "H(+) + L-tryptophan = CO2 + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8963864", "l": "CUBN dissociates from 25(OH)D (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37208", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869568", "l": "NPM1 binds TFAP2A homodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193997", "l": "CYP11B1 oxidises 11DCORT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40432", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665659", "l": "RAC1:GTP:FMNL1 binds profilin:G-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018699", "l": "1,1,1-trichloroethane reductive dehalogenase activity", "d": ["Catalysis of the reaction: 1,1,1-trichloroethane + 2 H+ + 2 e- = 1,1-dichloroethane + HCl."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52898", "l": "2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate => 2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62727", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) <=> (+)-isomalbrancheamide C + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40716", "l": "dihydroxyacetone phosphate + hexadecanoyl-CoA => 1-hexadecanoylglycerone 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58025", "l": "oleanolate + UDP-alpha-D-glucose => H(+) + oleanolate 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6802973", "l": "PLK3 phosphorylates CDC25C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42052", "l": "9-cis-retinol + NAD(+) = 9-cis-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41372", "l": "1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71670", "l": "malonate(out) + succinate(in) <=> malonate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61520", "l": "AH2 + dopamine = 3-tyramine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879930", "l": "STAT5 is recruited by JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140217", "l": "Transactivation of PMAIP1 (NOXA) by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612996", "l": "NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015213", "l": "uridine transmembrane transporter activity", "d": ["Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41850", "l": "NADP(+) + octanoyl-[ACP] => (2E)-octenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39638", "l": "3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10249", "l": "dUTP + H2O => diphosphate + dUMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60447", "l": "an S-substituted L-cysteinylglycine + H2O <=> an S-substituted L-cysteine + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75813", "l": "acetoacetate(in) + Na(+)(in) => acetoacetate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51318", "l": "H2O + N-(9Z-octadecenoyl)glycine => (9Z)-octadecenoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20197", "l": "[heparosan-N-sulfate](n) = [heparan-N-sulfate](n)", "d": []}, {"i": "EC:5.1.3.17", "l": "\"heparosan-N-sulfate-glucuronate 5-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61136", "l": "(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + quercetin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754616", "l": "SARS-CoV-2 E pentamer transports Ca2+  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37730", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21977", "l": "[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite => [thioredoxin]-dithiol + adenosine 5'-phosphosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21438", "l": "[translation elongation factor 2]-phosphate + ADP + H(+) => [translation elongation factor 2] + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68386", "l": "(2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate => (2E,6E)-farnesyl diphosphate + L-tryptophyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53254", "l": "5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lathosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64614", "l": "AMP + diphosphate + L-glutamyl-tRNA(Gln) => ATP + L-glutamate + tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22007", "l": "ATP + L-seryl-[myosin light chain] <=> ADP + H(+) + O-phospho-L-seryl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62139", "l": "dGMP + GTP <=> dGDP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45585", "l": "3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549322", "l": "OCT1 transports organic cations out of hepatic cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626681", "l": "Recruitment of transition zone proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42300", "l": "a fatty acyl-[ACP] + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.n5", "l": "\"glycerol-3-phosphate acyltransferase (acyl-[acyl-carrier-protein]-transferring)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168860", "l": "Membrane fusion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004663", "l": "Rab geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70913", "l": "(2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033936", "l": "polymannuronate hydrolase activity", "d": ["Catalysis of the endohydrolysis of the D-mannuronide linkages of polymannuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036370", "l": "D-alanyl carrier activity", "d": ["Binding a D-alanine and presenting it for processing or offloading to a cognate enzyme. Covalently binds the D-alanine via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The carrier protein provides an essential link between the D-alanine-D-alanyl carrier protein ligase and the incorporation of D-alanine into lipoteichoic acid by transferring activated D-alanine to cell membrane phosphatidylglycerol (PG)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008312", "l": "7S RNA binding", "d": ["Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-176318", "l": "Loading of claspin onto DNA during replication origin firing (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669012", "l": "EDA binds EDAR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75493", "l": "25-hydroxyvitamin D3 sulfate(in) + n H(+)(in) => 25-hydroxyvitamin D3 sulfate(out) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9625482", "l": "PTK2 binds activated EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12336", "l": "carboxymethoxysuccinate = fumarate + glycolate", "d": []}, {"i": "EC:4.2.99.12", "l": "\"carboxymethyloxysuccinate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24098", "l": "H(+) + isoscoparin + S-adenosyl-L-homocysteine => isoorientin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20855", "l": "ATP + H(+)(in) + H2O <=> ADP + 2 H(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52002", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O => a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26312", "l": "1,4-dihydroxy-2-naphthoyl-CoA + H2O <=> 1,4-dihydroxy-2-naphthoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047375", "l": "N-acetylgalactosaminoglycan deacetylase activity", "d": ["Catalysis of the reaction: H2O + N-acetyl-D-galactosaminoglycan = acetate + D-galactosaminoglycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40136", "l": "(9Z)-tetradecenoyl-CoA + H2O => (9Z)-tetradecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467794", "l": "Resolution of sister chromatids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.175", "l": "\"glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351913", "l": "Caspase-mediated cleavage of TJP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57157", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 => 4-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25872", "l": "H2O2 + pyridine = H2O + pyridine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29195", "l": "(S)-dihydroorotate + a menaquinone = a menaquinol + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854303", "l": "TBC1D11 binds RAB6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17114", "l": "H2O + L-serine-phosphoethanolamine => H(+) + L-serine + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.58", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009309", "l": "RUNX2 binds STUB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31044", "l": "(S)-methylmalonate semialdehyde + H2O + NAD(+) => 2 H(+) + methylmalonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57908", "l": "ATP + L-glutamyl-tRNA(Gln) = 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635446", "l": "Rv3654c binds SFPQ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947531", "l": "Molybdenum ion transfer onto molybdopterin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30695", "l": "3-aminopropanal + H2O + NAD(+) = beta-alanine + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2995388", "l": "PP2A dephosphorylates BANF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11969", "l": "AH2 + kynurenate + O2 => 7,8-dihydro-7,8-dihydroxykynurenate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75960", "l": "(S)-scoulerine + 2-oxoglutarate + O2 => (S)-3-O-demethylscoulerine + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36085", "l": "1-O-alkyl-sn-glycerol + H(+) + phosphocholine => 1-O-alkyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937989", "l": "RUNX1 binds PRC1 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694277", "l": "nsp8 generates RNA primers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58159", "l": "ATP + H2O + 4 Na(+)(in) <=> ADP + H(+) + 4 Na(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47603", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate <=> CMP + ganglioside GM4 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23315", "l": "2 sucrose <=> 1(F)-beta-D-fructosylsucrose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64430", "l": "glycyl-L-proline(in) + H(+)(in) => glycyl-L-proline(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68616", "l": "cortisone + H(+) + NADPH = cortisol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878654", "l": "ACP6 hydrolyses MYS-LPA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26484", "l": "diphosphate + N(6)-dimethylallyladenosine(37) in tRNA => adenosine(37) in tRNA + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102354", "l": "11-cis-retinol dehydrogenase activity", "d": ["Catalysis of the reaction: 11-cis-retinol + NADP = 11-cis-retinal + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449978", "l": "IL7 binds IL7R:JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420977", "l": "Ca permeable AMPA receptor ligand binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140069", "l": "histone butyryltransferase activity", "d": ["Catalysis of the reaction: butyryl-CoA + histone = CoA + butyryl-histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013435", "l": "RHOD auto-activates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50877", "l": "a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH => a hydroxy polyunsaturated fatty acid + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015473", "l": "fimbrial usher porin activity", "d": ["A porin that acts in the assembly of fimbria together with fimbrial chaperone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420980", "l": "Activation of Ca permeable AMPA receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70836", "l": "L-arginine(in) + L-glutamine(out) + Na(+)(out) => L-arginine(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047514", "l": "1,3-beta-D-glucan phosphorylase activity", "d": ["Catalysis of the reaction: [(1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate; substrates include laminarin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24065", "l": "2 5-aminolevulinate => H(+) + 2 H2O + porphobilinogen", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50973", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990424", "l": "protein arginine kinase activity", "d": ["Catalysis of the reaction: ATP + a protein arginine = ADP + protein arginine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64828", "l": "3-hydroxybenzyl alcohol + acetyl-CoA = 3-hydroxy-benzyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37252", "l": "cysteamine S-phosphate + H2O => cysteamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013143", "l": "RAC1 GEFs activate RAC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990929", "l": "sulfoquinovosidase activity", "d": ["Catalyzes the hydrolysis of terminal non-reducing alpha-sulfoquinovoside residues in alpha-sulfoquinovosyl diacylglycerides and alpha-sulfoquinovosyl glycerol, generating alpha-sulfoquinovose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928619", "l": "PAK1 binds RAC1:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730842", "l": "PI3K associates with phosphorylated GAB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193997", "l": "CYP11B1 oxidises 11DCORT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46221", "l": "androst-5-en-3beta,17beta-diol + NAD(+) => 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614460", "l": "Dimerization of procollagen type VI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034200", "l": "D,D-heptose 1,7-bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: D-beta-D-heptose 1,7-bisphosphate + H2O = D-beta-D-heptose 1-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13021", "l": "H(+) + NADH + O2 + vanillate = 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.82", "l": "\"vanillate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607722", "l": "Active NIK phosphorylates IKKA dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70575", "l": "3',5'-cyclic UMP + H2O = H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814153", "l": "ADO oxidises 2AET to HTAU (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376145", "l": "SRGAP binds ROBO1:SLIT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47710", "l": "ADP-alpha-D-glucose + phosphate => ADP + alpha-D-glucose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34366", "l": "H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP <=> diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46132", "l": "cholesterol + H(+) + NADPH + O2 = 25-hydroxycholesterol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63086", "l": "FAD + H(+) + 2 H2O + ilicicolin A => chloride + FADH2 + ilicicolin B + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27538", "l": "ethanol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624120", "l": "CEBPA binds CDK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047383", "l": "guanidinodeoxy-scyllo-inositol-4-phosphatase activity", "d": ["Catalysis of the reaction: 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74244", "l": "H2O + L-alanyl-tRNA(Pro) => H(+) + L-alanine + tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29784", "l": "ATP + H2O + L-cysteine(in) => ADP + H(+) + L-cysteine(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9660557", "l": "RAS:GTP binds RAL GDS proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66477", "l": "gypsogenate + UDP-alpha-D-glucose => gypsogenate 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612448", "l": "MXD4 gene expression is stimulated by ERBB4s80 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497824", "l": "BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64741", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine => 3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66494", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57932", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004349", "l": "glutamate 5-kinase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701488", "l": "Active ALK phosphorylates JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052818", "l": "heteroglycan 3-alpha-mannosyltransferase activity", "d": ["Catalysis of the reaction: heteroglycan + GDP-mannose = (1->3)-alpha-D-mannosylheteroglycan + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76067", "l": "(S)-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-methionine = (S)-cis-N-methyl-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050320", "l": "tartrate epimerase activity", "d": ["Catalysis of the reaction: L-tartrate = (2R,3S)-tartrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53255", "l": "lathosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43991", "l": "(2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2 <=> (2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25255", "l": "ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate => ATP + N-acetyl-D-mannosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375140", "l": "CDO binds promyogenic cadherins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11651", "l": "(-)-menthol + H(+) + NADPH + O2 <=> 1,4-menthane-3,8-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72700", "l": "acrylate + H(+) + NADH => NAD(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58336", "l": "a 4-hydroxynonen-1-ol + NADP(+) = a 4-hydroxynonenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65690", "l": "a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59938", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+) => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53643", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-amorphene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66043", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856525", "l": "ANGPTL8 binds ANGPTL3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086041", "l": "voltage-gated potassium channel activity involved in SA node cell action potential depolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730842", "l": "PI3K associates with phosphorylated GAB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33033", "l": "D-sorbitol + NAD(+) => H(+) + keto-D-fructose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50637", "l": "a 3-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73174", "l": "adenosine 3',5'-bisphosphate(out) + NAD(+)(in) <=> adenosine 3',5'-bisphosphate(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2167942", "l": "Collagen type XIII ectodomain shedding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62785", "l": "2 fonsecin B + H(+) + NADPH + O2 => bifonsecin B + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.138", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36295", "l": "alpha-maltose 6'-phosphate + H2O = D-maltose + phosphate", "d": []}, {"i": "EC:3.1.3.90", "l": "\"maltose 6'-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21778", "l": "(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate => (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28060", "l": "L-xylulose => L-lyxopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53198", "l": "16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728752", "l": "TAS2R:bitter compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1370505", "l": "PRLR is phosphorylated at Ser-349 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26154", "l": "6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate => (2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031879", "l": "type 2 somatostatin receptor binding", "d": ["Binding to a type 2 somatostatin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003834", "l": "beta-carotene 15,15'-dioxygenase activity", "d": ["Catalysis of the reaction: all-trans-beta-carotene + O2 = 2 all-trans-retinal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855232", "l": "RELN:VLDLR binds DAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10195", "l": "ATP + H2O + sulfate(out) <=> ADP + H(+) + phosphate + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665525", "l": "sCD163 translocates from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39328", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA => (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030294", "l": "receptor signaling protein tyrosine kinase inhibitor activity", "d": ["Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39015", "l": "22-oxodocosanoate + H2O + NAD(+) = docosanedioate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36218", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40478", "l": "1,2,3-tributanoylglycerol + H2O <=> butanoate + dibutanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72902", "l": "4-O-demethylbarbatate + S-adenosyl-L-methionine <=> proatranorin I + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984671", "l": "Chromokinesins form dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37158", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002134", "l": "UTP binding", "d": ["Binding to UTP, uridine 5'-triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964287", "l": "G alpha (s):GTP:SRC dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58722", "l": "H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide => (S)-nicotine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25455", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + germacrene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673296", "l": "WNT5:FZD7 binds p-DVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31091", "l": "acetyl-CoA + dodecanoyl-CoA = 3-oxotetradecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52691", "l": "3-phenyllactate + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75065", "l": "chloride(in) + 2 hydrogencarbonate(out) + Li(+)(out) => chloride(out) + 2 hydrogencarbonate(in) + Li(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53112", "l": "3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27512", "l": "dehydro coenzyme F420-0 + GMP + H(+) => 7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32927", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20301", "l": "ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)", "d": []}, {"i": "EC:6.1.1.19", "l": "\"arginine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052593", "l": "tryptamine:oxygen oxidoreductase (deaminating) activity", "d": ["Catalysis of the reaction: tryptamine + H2O + O2 = NH3 + indole acetaldehyde + hydrogen peroxide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693347", "l": "HTR1A binds 5HT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349455", "l": "Phosphorylation of MDM4 by ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22164", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = globoside Forssman (d18:1(4E)) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.88", "l": "\"globoside alpha-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875816", "l": "STAT3 binds activated MET receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757686", "l": "SERPINA6 binds PREDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32213", "l": "(2E,4Z)-2-hydroxyhexa-2,4-dienedioate => (Z)-5-oxohex-2-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14138", "l": "3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine => 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627369", "l": "SEPT4 binds XIAP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21003", "l": "1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene <=> 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692135", "l": "SOX9, NR5A1 (SF1), and GATA4 bind the AMH gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028728", "l": "NTRK2 phosphorylates FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48973", "l": "ATP + H2O + phosphite(out) => ADP + H(+) + phosphate + phosphite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448632", "l": "IL34 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21129", "l": "S-adenosyl-L-methionine + zymosterol => fecosterol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73189", "l": "(2R,3S,11R)-aszonalenin + diphosphate => (R)-benzodiazepinedione + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1008200", "l": "NFE2 binds the beta globin locus control region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53187", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O <=> 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55562", "l": "a hydroxy-epoxy-eicosatetraenoate => a hydroperoxyeicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9670014", "l": "Factor VIIIa dissociates  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41332", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65693", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine => a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55195", "l": "2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 <=> 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72945", "l": "2 Na(+)(in) + pyruvate(in) => 2 Na(+)(out) + pyruvate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781922", "l": "USP13 binds UFD1L:SKP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953336", "l": "Expression of EXTL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10900", "l": "an aromatic L-alpha-amino acid + glyoxylate = an aromatic oxo-acid + glycine", "d": []}, {"i": "EC:2.6.1.60", "l": "\"aromatic-amino-acid--glyoxylate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426489", "l": "RISC binds inexactly matching target RNAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203070", "l": "Association of profilin with monomeric actin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43952", "l": "3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 = H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036479", "l": "peroxidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of peroxidase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26267", "l": "dehydroabietate + 2 H(+) + NADPH => dehydroabietadienal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61435", "l": "(R)-8-oxocitronellyl enol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-378975", "l": "Follitropin is a heterodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71618", "l": "(S)-malate(in) + sulfate(out) <=> (S)-malate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60941", "l": "(9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => (9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016852", "l": "sirohydrochlorin cobaltochelatase activity", "d": ["Catalysis of the reaction: sirohydrochlorin + Co2+ = cobalt-sirohydrochlorin + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112436", "l": "Formation of Elongin complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35293", "l": "3-oxoisopentadecanoyl-CoA + CO2 + CoA => 11-methyldodecanoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9659820", "l": "RB1 translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44753", "l": "2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730835", "l": "Autophosphorylation of PKC-theta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3878762", "l": "Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48642", "l": "11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071820", "l": "N-box binding", "d": ["Binding to an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24816", "l": "2-oxoglutarate + L-valine <=> 3-methyl-2-oxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940554", "l": "MMP2 cleaves OPTC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416690", "l": "SEMA4A binds to PLXND1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54068", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = diphosphate + sesterfisherol", "d": []}, {"i": "EC:4.2.3.176", "l": "\"sesterfisherol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11677", "l": "D-ribose + H2O + NADP(+) => D-ribonate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036524", "l": "protein deglycase activity", "d": ["Catalysis of the removal of a sugar or dicarbonyl from a lysine residue of a glycated protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665232", "l": "Resistant ERBB2 KD mutants do not bind trastuzumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31403", "l": "all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) = all-trans-4,4'-diaponeurosporene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52873", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate => 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57198", "l": "glycolate + H(+) + L-cysteinyl-[protein] => H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47978", "l": "dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49286", "l": "CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate => 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018449", "l": "1-phenylethanol dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-1-phenylethanol = acetophenone + H2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28192", "l": "2'-deoxyinosine + NH4(+) => 2'-deoxyadenosine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164840", "l": "ADP and Pi bind to ATPase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42976", "l": "L-tryptophan = 2-aminoprop-2-enoate + indole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51700", "l": "S-adenosyl-L-methionine + xanthogalenol = 4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10999", "l": "2-methylpropanal oxime + S-adenosyl-L-methionine <=> 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35591", "l": "H2 + n sulfur = H(+) + hydrogen sulfide + (n-1) sulfur", "d": []}, {"i": "EC:1.12.98.4", "l": "\"sulfhydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375144", "l": "Interaction of NCAM1:GFRalpha-1 with GDNF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59093", "l": "[(1->3)-alpha-D-glucosyl](n) + sucrose => [(1->3)-alpha-D-glucosyl](n+1) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73086", "l": "chrysoeriol + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + velutin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050388", "l": "uronate dehydrogenase activity", "d": ["Catalysis of the reaction: D-galacturonate + H2O + NAD+ = galactarate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.28", "l": "\"nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42303", "l": "a fatty acyl-[ACP] + sn-glycerol 3-phosphate <=> a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44685", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047158", "l": "sinapoylglucose-sinapoylglucose O-sinapoyltransferase activity", "d": ["Catalysis of the reaction: 2 1-O-sinapoyl-beta-D-glucose = 1,2-di-O-sinapoyl-beta-D-glucose + D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47822", "l": "9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17500", "l": "formononetin + UDP-alpha-D-glucose <=> ononin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60073", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 => 4beta-hydroxymethyl-4alpha-methylzymosterol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990473", "l": "ciliary targeting signal binding", "d": ["Binding to a ciliary targeting sequence, a specific peptide sequence that acts as a signal to localize a membrane protein to the ciliary membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55988", "l": "H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}, {"i": "EC:3.2.1.106", "l": "\"mannosyl-oligosaccharide glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0003796", "l": "lysozyme activity", "d": ["Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624948", "l": "KIF17 enters the cilium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9705926", "l": "AR binds AR agonists (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18267", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH => 6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54794", "l": "diphosphate + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein] => L-histidyl-[protein] + N(7)-methyl-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798004", "l": "TP53 stimulates BNIP3L expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11988", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.79", "l": "\"cyclopropane-fatty-acyl-phospholipid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62683", "l": "naphtopyrone YWA1 <=> H(+) + H2O + norrubrofusarin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34200", "l": "2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 => bracteatin 6-O-beta-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14699", "l": "(2E,6E)-farnesal + H(+) + NADPH => (2E,6E)-farnesol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72697", "l": "Start codon recognition (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948775", "l": "MKRN1 polyubiquitinates PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59693", "l": "D-cellotriono-1,5-lactone + H2O => D-cellotrionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16328", "l": "1-phospho-alpha-D-glucuronate + H(+) + UTP <=> diphosphate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57948", "l": "2-hydroxytoluene + H(+) + NADH + O2 = 3-methylcatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54119", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + pseudolaratriene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19751", "l": "[(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP => [(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102735", "l": "trihydroxybenzophenone synthase activity", "d": ["Catalysis of the reaction: benzoyl-CoA + 3 malonyl-CoA + 3 H+ = 2,4,6-trihydroxybenzophenone + 4 coenzyme A + 3 carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51726", "l": "adenosine 5'-tetraphosphate + ADP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34247", "l": "1-deoxymethyl-sphinganine + NADP(+) = 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141316", "l": "TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36267", "l": "caffeine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36529", "l": "(13Z)-3-oxodocosenoyl-CoA + CO2 + CoA => (11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14624", "l": "(S)-2,3-epoxysqualene <=> lanosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73575", "l": "(E,E)-piperate + ATP + H(+) = (E,E)-piperoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784959", "l": "BPHL hydrolyses VACV to ACV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29524", "l": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847880", "l": "CYTH proteins bind ARF1:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20967", "l": "2-oxoglutarate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674093", "l": "PDGFRs bind type I TKI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16634", "l": "guanosine(34) in tRNA + queuine => guanine + queuosine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070742", "l": "C2H2 zinc finger domain binding", "d": ["Binding to a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69592", "l": "CMP + inosine = cytidine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010736", "l": "serum response element binding", "d": ["Binding to a serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49538", "l": "(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O => 2-amino-2-deoxy-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655278", "l": "Activated FGFR1 mutants phosphorylate FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39299", "l": "(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917839", "l": "apo-Transferrin dissociates from the receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39196", "l": "3-oxotetracosanoyl-CoA + H(+) + NADPH => (3R)-hydroxytetracosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1253343", "l": "WWOX binds ERBB4s80 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854303", "l": "TBC1D11 binds RAB6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015043", "l": "leghemoglobin reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + 2 ferrileghemoglobin = NADP+ + 2 ferroleghemoglobin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29939", "l": "H(+)(in) + phosphate(in) = H(+)(out) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72988", "l": "myo-inositol(out) + 2 Na(+)(out) => myo-inositol(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16371", "l": "H(+) + NADH + pyruvate => (R)-lactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44834", "l": "CoA + O-tetradecanoyl-(R)-carnitine => (R)-carnitine + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694572", "l": "3a localizes to the cell membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983158", "l": "Trimming of peptides in ER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10026", "l": "H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine => L-lysyl-[histone] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209921", "l": "Monoiodinated tyrosine can be deiodinated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52149", "l": "a (Z)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose => an aliphatic (Z)-desulfo-glucosinolate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25183", "l": "CoA + H(+) + N-acetylputrescine => acetyl-CoA + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47857", "l": "ganglioside GD1a (d18:1(4E)) + H2O => ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23428", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56913", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) => (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35040", "l": "spermidine(in) => spermidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071933", "l": "Arp2/3 complex binding", "d": ["Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446322", "l": "PARVA associates with Paxillin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165162", "l": "Phosphorylation of TSC2 by PKB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209925", "l": "DIT and MIT combine to form triiodothyronine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10698", "l": "AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase] => a long-chain fatty acid + ATP + holo-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114284", "l": "Release of Cytochrome c from mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18966", "l": "hydroxymethylbilane => H2O + uroporphyrinogen III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44727", "l": "2,3-saturated fatty aldehyde + NADP(+) <=> (2E)-fatty aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57634", "l": "H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase] => ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74025", "l": "L-alanine(out) + L-serine(in) => L-alanine(in) + L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68747", "l": "2 (R)-3-phenyllactate + 2 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022A + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352268", "l": "Cleavage of Satb1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38018", "l": "delta-tocotrienol <=> 6-geranylgeranyl-2-methylbenzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473184", "l": "Follistatin (FST) binds Activin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35324", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) => (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73816", "l": "O2 + piceatannol => 3,4-dihydroxybenzaldehyde + 3,5-dihydroxybenzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20953", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose => beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57315", "l": "H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine <=> cytidine 5'-diphosphoramidate + H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18197", "l": "N-cyclohexylformamide = cyclohexyl isocyanide + H2O", "d": []}, {"i": "EC:4.2.1.103", "l": "\"cyclohexyl-isocyanide hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.193", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24315", "l": "L-lysyl-[cytochrome c] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848818", "l": "PTK6 phosphorylates CBL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16773", "l": "ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GM1 (d18:1(4E)) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.62", "l": "\"ganglioside galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632412", "l": "PTK2 is recruited to methylated ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13904", "l": "H2O + N-(aminomethyl)urea <=> N-(hydroxymethyl)urea + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68058", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47264", "l": "2,6,10,14-tetramethylpentadecanoate + ATP + CoA = AMP + diphosphate + pristanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36397", "l": "7-dehydrodesmosterol + H(+) + NADPH => 7-dehydrocholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.369838362782886", "identifiers": [{"i": "GO:0042165", "l": "neurotransmitter binding", "d": ["Binding to a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760122", "l": "AcK-NFE2L2-dependent GCLC gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18951", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol => O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-354173", "l": "Activation of Rap1 by cytosolic GEFs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52217", "l": "[(1''->2')-ADP-alpha-D-ribose](n) + H2O => [(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16463", "l": "ADP + H(+) + phosphate + urate(out) => ATP + H2O + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446372", "l": "Association of  PARVA with TESK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216045", "l": "Collagen type I binds integrin alpha11beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28878", "l": "H(+)(in) + L-tyrosine(in) <=> H(+)(out) + L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41076", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24666", "l": "H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide => 2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449829", "l": "IL11 binds IL11RA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52262", "l": "a bacteriochlorophyllide e + H2O => a 7(1),7(1)-dihydroxybacteriochlorophyllide c", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675947", "l": "TNFSF18 binds TNFRSF18 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31897", "l": "alpha-humulene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391211", "l": "Trace amine-associated receptors can bind trace amines (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57216", "l": "dGTP + glyoxal = N(2)-(1-hydroxy-2-oxoethyl)-dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14404", "l": "chlordecone alcohol + NADP(+) <=> chlordecone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071532", "l": "ankyrin repeat binding", "d": ["Binding to an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047941", "l": "glucuronolactone reductase activity", "d": ["Catalysis of the reaction: L-gulono-1,4-lactone + NADP+ = D-glucurono-3,6-lactone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10057", "l": "(3S)-3-aminobutanoyl-CoA => (2E)-butenoyl-CoA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202713", "l": "CD84 homodimerises (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004503", "l": "tyrosinase activity", "d": ["Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35475", "l": "(1'S,5'S)-5'-hydroxyaverantin + NAD(+) = (S)-5'-oxoaverantin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35336", "l": "H(+) + isopentadecanoyl-CoA + malonyl-CoA => 3-oxoisoheptadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55561", "l": "a hydroperoxyeicosatetraenoate => a hydroxy-epoxy-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850794", "l": "SPINK6 binds KLK5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3858482", "l": "DVL is recruited to the receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770145", "l": "Formation of the Spliceosomal Bact complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49344", "l": "2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41972", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) = CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691174", "l": "RAC1 binds effectors at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66264", "l": "ATP + H(+) + nonanoate = diphosphate + nonanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70972", "l": "D-dopa + H2O + O2 => 3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33261", "l": "N-formimidoylglycine + NH4(+) => 4-aminoimidazole + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791109", "l": "GADD45A binds PCNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647631", "l": "GSDMD (1-275) binds PIPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66352", "l": "(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+) = (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621179", "l": "Cinaciguat binds sGC:NO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.353", "l": "\"demethylluteothin O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19040", "l": "an epoxide + H2O <=> an ethanediol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52409", "l": "4-phospho-D-erythronate + NAD(+) => CO2 + dihydroxyacetone phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209320", "l": "Activated TAK1 kinase is autophosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-448958", "l": "Nuclear translocation of p38 MAPK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603784", "l": "PEX19:class I PMP binds PEX3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097161", "l": "DH domain binding", "d": ["Binding to a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31673", "l": "dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38959", "l": "a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2", "d": []}, {"i": "EC:1.3.3.6", "l": "\"acyl-CoA oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0015616", "l": "DNA translocase activity", "d": ["Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23905", "l": "an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] => 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45540", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46590", "l": "calcidiol + H2O + 2 oxidized [adrenodoxin] => calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657651", "l": "MGMT binds alkylated DNA containing 6-O-methylguanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58280", "l": "4 ATP = cyclic tetraadenylate + 4 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804266", "l": "CHEK2 phosphorylates TTC5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622415", "l": "RIP2 binds NEMO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47850", "l": "CO2 + diphosphate + thiamine phosphate => 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65053", "l": "4-(trifluoromethyl)benzyl alcohol + NAD(+) => 4-(trifluoromethyl)benzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72039", "l": "nicotinate(in) + orotate(out) = nicotinate(out) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70772", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443783", "l": "Interaction of NUMB with L1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851298", "l": "GPR143 binds L-Dopa (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429714", "l": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948775", "l": "MKRN1 polyubiquitinates PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30284", "l": "(-)-trans-permethrin + H2O => (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374723", "l": "Nociceptin receptor binds to nociceptin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417908", "l": "P2RY1 binds ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60175", "l": "5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate <=> (2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39262", "l": "(3R)-hydroxy-(13Z)-docosenoyl-CoA <=> (2E,13Z)-docosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33036", "l": "2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73474", "l": "D-ornithine(in) + L-ornithine(out) <=> D-ornithine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106415", "l": "muramoyltetrapeptide carboxypeptidase activity", "d": ["GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H2O = GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57048", "l": "AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42505", "l": "2-oxoglutarate + N(6)-acetyl-L-lysine => 6-acetamido-2-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694581", "l": "RTC synthesizes SARS-CoV-2 plus strand genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45768", "l": "gamma-L-glutamyl-L-alaninol + H2O = L-alaninol + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41291", "l": "H2O + N-dodecanoylsphing-4-enine = dodecanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52799", "l": "2 H(+) + Ni-sirohydrochlorin <=> Ni(2+) + sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38613", "l": "cyclic ADP-beta-D-ribose + H(+) + nicotinamide => NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73248", "l": "ladanein + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034555", "l": "3,3'-dibromobisphenol A reductive dehalogenase activity", "d": ["Catalysis of the reaction: 3,3'-dibromobisphenol A + 2 H+ + 2 e- = 3-monobromobisphenol A + HBr."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61371", "l": "4-methylumbelliferone sulfate(in) + ATP + H2O <=> 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139920", "l": "Translocation of tBID to mitochondria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30136", "l": "dodecanoyl-CoA + H2O => CoA + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29249", "l": "3 H(+)(in) + 2 Na(+)(out) => 3 H(+)(out) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140908", "l": "histone H3K122 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 122) = CoA + histone H3 N6-acetyl-L-lysine (position 122)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938231", "l": "RUNX1:CBFB binds CREBBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788628", "l": "p-Y-STATs dissociate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61602", "l": "[DsbB protein]-dithiol + [protein]-disulfide => [DsbD protein]-disulfide + [protein]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27827", "l": "hydrogen sulfide + O-succinyl-L-homoserine => L-homocysteine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70110", "l": "(S)-5-carboxymethyl-tetronate + o-quinone methide <=> H(+) + penilactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.42", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050594", "l": "tabersonine 16-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + tabersonine = 16-hydroxytabersonine + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17096", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9796626", "l": "MIB2 ubiquitinates CFLAR  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50802", "l": "prostaglandin A2-S-(S)-glutathione => glutathione + prostaglandin A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26382", "l": "4-hydroxybutanoate + NADP(+) => H(+) + NADPH + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187332", "l": "Cytosolic CMs translocate to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23280", "l": "acetyl-CoA + cysteamine = CoA + S-acetylcysteamine", "d": []}, {"i": "EC:2.3.1.11", "l": "\"thioethanolamine S-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0003712", "l": "transcription coregulator activity", "d": ["A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46846", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46857", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709547", "l": "ESTG binds ESR2:chaperone complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52299", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75819", "l": "(5Z,8Z)-octadecadienoate + O2 = (5S)-hydroperoxy-(6E,8Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64505", "l": "AH2 + H(+) + 3 malonyl-CoA + propanoyl-CoA + 2 S-adenosyl-L-methionine => 2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031812", "l": "P2Y1 nucleotide receptor binding", "d": ["Binding to a P2Y1 nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74610", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-galactosamine(out) <=> UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-galactosamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0009982", "l": "pseudouridine synthase activity", "d": ["Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72361", "l": "glutarate(out) + succinate(in) => glutarate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71491", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070042", "l": "rRNA (uridine-N3-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70894", "l": "L-asparagine(out) + L-glutamine(in) + Na(+)(out) <=> L-asparagine(in) + L-glutamine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58913", "l": "ATP + H2O + iron(III) dicitrate(out) => ADP + H(+) + iron(III) dicitrate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419145", "l": "5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61658", "l": "(2E,6E)-farnesyl phosphate + ADP + H(+) => (2E,6E)-farnesol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218814", "l": "PAK2 autophorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12616", "l": "2 glutathione + L-cystine <=> glutathione disulfide + 2 L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327746", "l": "FN1 aggregation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034917", "l": "2-methylhex-2-enoyl-CoA hydratase activity", "d": ["Catalysis of the reaction: 2-methylhex-2-enoyl-CoA + H2O = 3-hydroxy-2-methylhexanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606807", "l": "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42936", "l": "S-adenosyl-L-methionine + uridine(32) in tRNA = 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56338", "l": "ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160039", "l": "serotonin-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when the biogenic amine serotonin has been bound by the channel complex or one of its constituent parts. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30456", "l": "(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O => (-)-geosmin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700120", "l": "PTN and MDK bind to PTPRZ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2299725", "l": "PGH2 diffuses from the endoplasmic reticulum lumen to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65831", "l": "H2O + neryl diphosphate <=> diphosphate + nerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15836", "l": "(S)-4-hydroxymandelate + H(+) + O2 <=> 4-hydroxybenzaldehyde + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65682", "l": "a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6813740", "l": "GDE1 hydrolyzes GroPIns (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:1904399", "l": "heparan sulfate binding", "d": ["Binding to heparan sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38086", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72434", "l": "(E)-caffeate + ATP + H(+) <=> (E)-caffeoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34952", "l": "3-hydroxypropanoate(out) => 3-hydroxypropanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22898", "l": "a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+) => acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050382", "l": "uracil-5-carboxylate decarboxylase activity", "d": ["Catalysis of the reaction: H+ + uracil 5-carboxylate = CO2 + uracil."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60423", "l": "H2O + triglucosyl-enterobactin <=> [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60855", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015369", "l": "calcium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73421", "l": "L-glutamine(in) => L-glutamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64299", "l": "(4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH <=> (4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14604", "l": "L-lysine + O2 <=> 5-aminopentanamide + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58069", "l": "(E)-isoeugenol + O2 => acetaldehyde + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030160", "l": "synaptic receptor adaptor activity", "d": ["The binding activity of a molecule that provides a physical support bridging a synaptic signaling receptor and a downstream signaling molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10447", "l": "(S)-reticuline + S-adenosyl-L-methionine <=> (S)-laudanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635996", "l": "NEIL3 resolves psoralen-induced ICLs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047228", "l": "1,2-diacylglycerol 3-glucosyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacylglycerol + UDP-D-glucose = 3-D-glucosyl-1,2-diacylglycerol + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30090", "l": "(S)-2-hydroxyglutarate + FAD + H(+) <=> 2-oxoglutarate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33378", "l": "a 1-acylglycerone 3-phosphate + H(+) + NADPH <=> a 1-acyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114683", "l": "Phosphorylation of Platelet Sec-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54629", "l": "2-oxoglutarate + dodecanoyl-CoA + O2 => 2-hydroxydodecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877192", "l": "RUNX1 binds FOXP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67806", "l": "CO2 + formaldehyde + L-lysyl(20)-[histone H4] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(20)-[histone H4] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53752", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709883", "l": "BIL:ALB scavenges O2.- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102280", "l": "choline monooxygenase activity (NADP-dependent)", "d": ["Catalysis of the reaction: choline + NADP = betaine aldehyde + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68102", "l": "H(+) + L-xylulose + NADH => NAD(+) + xylitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73757", "l": "Binding of RRN3 to RNA Polymerase I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66898", "l": "4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase] => 4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74085", "l": "diphosphate + menaquinol-4 => (2E,6E,10E)-geranylgeranyl diphosphate + menadiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648888", "l": "p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877620", "l": "ECE2 cleaves EDN1(53-90) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388503", "l": "Oxytocin receptor bind oxytocin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31187", "l": "(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956568", "l": "RUNX1 binds the core TAL1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32880", "l": "(1R,4R,5R)-5-hydroxycamphor + NAD(+) => (1R,4R)-bornane-2,5-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0050811", "l": "GABA receptor binding", "d": ["Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63194", "l": "glycine betaine + 2 H(+) + phosphate => [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682377", "l": "LC3 de-lipidation by ATG4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71162", "l": "H(+)(in) + L-serine(out) + Na(+)(out) <=> H(+)(out) + L-serine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433456", "l": "Recruitment of STATs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2247513", "l": "STAB1:ligand is endocytosed (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73366", "l": "beta-alanyl-[peptidyl-carrier protein] + dopamine <=> beta-alanyl-dopamine + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57241", "l": "glyoxal + GMP => N(2)-(1-hydroxy-2-oxoethyl)-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5688834", "l": "ATXN3 binds VCP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54219", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 <=> 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35870", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14477", "l": "a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.7", "l": "\"medium-chain acyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419011", "l": "Transhomodimerization of Nectins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693061", "l": "STAMBP binds STAM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58258", "l": "ADP-D-ribose + L-seryl-[protein] => H2O + O-(ADP-D-ribosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174058", "l": "Degradation of multiubiquitinated Cdh1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72640", "l": "1,6-dihydroxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine => 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047467", "l": "4-hydroxyphenylacetaldehyde-oxime isomerase activity", "d": ["Catalysis of the reaction: (E)-4-hydroxyphenylacetaldehyde oxime = (Z)-4-hydroxyphenylacetaldehyde oxime."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73312", "l": "L-thyroxine sulfate(out) => L-thyroxine sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62492", "l": "ATP + holo-[peptidyl-carrier protein] + L-arginine = AMP + diphosphate + L-arginyl-[peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.63", "l": "\"L-arginine--[L-arginyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008520", "l": "L-ascorbate:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in)."]}, {"i": "TCDB:2.A.40.6.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65220", "l": "(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.164", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688797", "l": "ATXN3 family cleave Ub chains (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54867", "l": "H(+) + NADPH + O2 + sulcatone <=> 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8934446", "l": "Activated PKC phosphorylates SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45172", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983680", "l": "OAS1 produces oligoadenylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.6", "l": "\"exodeoxyribonuclease VII\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102647", "l": "D-ribose 5-phosphate:D-sedoheptulose 7-phosphate transaldolase activity", "d": ["Catalysis of the reaction: sedoheptulose 7-phosphate + D-ribose 5-phosphate <=> D-glycero-D-altro-octulose 8-phosphate + D-erythrose 4-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697077", "l": "Rv1410c transports lprG:LM,LAM from cytosol to the cell wall (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15537", "l": "(2R)-3-sulfolactate + NADP(+) = 3-sulfopyruvate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.338", "l": "\"(2R)-3-sulfolactate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018666", "l": "2,4-dichlorophenol 6-monooxygenase activity", "d": ["Catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9704248", "l": "CHRM4 binds CHRM4 antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37964", "l": "galactitol + NAD(+) => D-galactose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103007", "l": "indole-3-acetate carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: indole-3-acetate + S-adenosyl-L-methionine <=> methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686578", "l": "Activated ATM phosphorylates ABL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19823", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202233", "l": "Inactivation of Lck by Csk (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75246", "l": "acetyl-CoA + N-terminal L-leucyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-leucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3095889", "l": "MMACHC dealkylates RCbl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975594", "l": "PLB1 hydrolyses RPALM to atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41562", "l": "(3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O => (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47871", "l": "di-(9Z)-octadecenoylglycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31775", "l": "all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61894", "l": "a 4,5-saturated-(3E)-enoyl-CoA + NADP(+) => a (2E,4Z)-dienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.863640214551324", "identifiers": [{"i": "GO:0003727", "l": "single-stranded RNA binding", "d": ["Binding to single-stranded RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63164", "l": "H2O + N-tricosanoyl-taurine = taurine + tricosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6795290", "l": "TORC2 complex phosphorylates SGK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5221014", "l": "TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604763", "l": "Autocatalytic activation of MMP7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381435", "l": "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013143", "l": "RAC1 GEFs activate RAC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46463", "l": "(22R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56503", "l": "(R)-3,5-bisphosphomevalonate + H(+) <=> CO2 + isopentenyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730902", "l": "Oligomerization of p-CARMA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2430535", "l": "MASTL phosphorylates ENSA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75945", "l": "3-guanidinopropanoate + L-ornithine => beta-alanine + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1362416", "l": "Frataxin binds iron (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41616", "l": "D-ribose 2,5-bisphosphate + H2O = D-ribose 5-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11590", "l": "AH2 + isoquinolin-1(2H)-one => A + H2O + isoquinoline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031857", "l": "type 1 parathyroid hormone receptor binding", "d": ["Binding to a type 1 parathyroid hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50185", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48860", "l": "18-HEPE + O2 = (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11392", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625015", "l": "Defective SLC1A3 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19336", "l": "H(+) + oxalyl-CoA <=> CO2 + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11256", "l": "H2O + limonin + UDP-alpha-D-glucose = glucosyl-limonin + 2 H(+) + UDP", "d": []}, {"i": "EC:2.4.1.210", "l": "\"limonoid glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72691", "l": "Formation of the 43S pre-initiation complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36352", "l": "AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine => 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0016778", "l": "diphosphotransferase activity", "d": ["Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor)."]}, {"i": "EC:2.7.6.-", "l": "\"Diphosphotransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58470", "l": "2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate => 2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16123", "l": "3-(carbamoylamino)propanoate + H(+) => 5,6-dihydrouracil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14350", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose => an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48646", "l": "(12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde => prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36044", "l": "all-trans-8'-apo-beta-carotenal + O2 => 13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47691", "l": "cis-4-hydroxy-L-proline + NADP(+) <=> Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390912", "l": "HRH1 binds hist (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432010", "l": "Aquaporin-1 passively transports water into cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55313", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52718", "l": "a long-chain primary fatty alcohol + CoA + 2 NADP(+) => a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30720", "l": "acetyl-CoA + propanoyl-CoA => 2-methyl-3-oxobutanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18769", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate = 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate", "d": []}, {"i": "EC:5.3.2.5", "l": "\"2,3-diketo-5-methylthiopentyl-1-phosphate enolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58263", "l": "H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] <=> ADP-D-ribose + L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912372", "l": "Fringe-modified Pre-NOTCH is cleaved by FURIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15850", "l": "2 Fe(III)-[cytochrome c] + L-ascorbate => 2 Fe(II)-[cytochrome c] + 2 H(+) + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63214", "l": "5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O => 5-amino-6-(D-ribitylamino)uracil + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67753", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662606", "l": "MT3 binds zinc (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783670", "l": "CRLF1 binds CLCF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398185", "l": "LARG binds plexin B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730835", "l": "Autophosphorylation of PKC-theta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005164", "l": "tumor necrosis factor receptor binding", "d": ["Binding to a tumor necrosis factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848829", "l": "CBL autoubiquitinates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102465", "l": "zeaxanthin 2,2'-beta-hydroxylase activity", "d": ["Catalysis of the reaction: zeaxanthin + 2 NADH + 2 H+ + 2 O2 <=> nostoxanthin + 2 NAD + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28475", "l": "D-glucarate(in) + H(+)(in) => D-glucarate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33498", "l": "all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate <=> 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74385", "l": "2 (S)-lactate(out) + prostaglandin E2(in) => 2 (S)-lactate(in) + prostaglandin E2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218906", "l": "RIPK3 phosphorylates MLKL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61475", "l": "a sphingoid base + hexadecanoyl-CoA <=> an N-hexadecanoyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769401", "l": "DKK and KRM bind LRP5/6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166817", "l": "Cleavage of C3 by C3 convertases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19417", "l": "[phosphate](n) + a dolichyl diphosphate = [phosphate](n+1) + a dolichyl phosphate", "d": []}, {"i": "EC:2.7.4.20", "l": "\"dolichyl-diphosphate--polyphosphate phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983422", "l": "Disassembly of COPII coated vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50030", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine => H2O + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38142", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10293", "l": "acetyl-CoA + D-glucosamine 6-phosphate => CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21227", "l": "CDP-choline + sphing-4-enine <=> CMP + H(+) + sphing-4-enine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31985", "l": "abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45729", "l": "(E)-caffeyl alcohol + NADP(+) => (E)-caffeyl aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0140852", "l": "histone ubiquitin ligase activity", "d": ["Catalysis of the transfer of ubiquitin to a histone substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48174", "l": "N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate => ganglioside GM2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850777", "l": "SPINK6 binds KLK14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23712", "l": "NADP(+) + pregnan-21-ol = H(+) + NADPH + pregnan-21-al", "d": []}, {"i": "EC:1.1.1.151", "l": "\"21-hydroxysteroid dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43019", "l": "an S-alkyl-L-cysteine <=> 2-aminoprop-2-enoate + an alkyl thiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56669", "l": "7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74590", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-exo-beta-bergamotene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49854", "l": "(2E)-octenoyl-CoA => (3E)-octenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73943", "l": "dehydrogriseofulvin + H(+) + NADPH = griseofulvin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50243", "l": "[hyaluronan](n) <=> n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54376", "l": "(+)-copalyl diphosphate + H2O = diphosphate + nezukol", "d": []}, {"i": "EC:4.2.3.183", "l": "\"nezukol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56117", "l": "2-all-trans-decaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43619", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709883", "l": "BIL:ALB scavenges O2.- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41318", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17450", "l": "(2E)-geranyl diphosphate + flaviolin => 3-linalylflaviolin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014812", "l": "ROBOs bind keratan sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102830", "l": "verbascose synthase activity", "d": ["Catalysis of the reaction: 2 stachyose <=> verbascose + raffinose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29529", "l": "a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008405", "l": "arachidonic acid 11,12-epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid."]}, {"i": "RHEA:51480", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684301", "l": "mRNA1 is translated to pp1a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74672", "l": "UDP-beta-L-arabinopyranose(in) + UMP(out) => UDP-beta-L-arabinopyranose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15830", "l": "a 16alpha-hydroxysteroid => a 16beta-hydroxysteroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53671", "l": "(2E,6E)-farnesyl diphosphate <=> (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23840", "l": "3-(2,3-dihydroxyphenyl)propanoate + O2 = (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35306", "l": "3-hydroxyisopentadecanoyl-CoA + NADP(+) <=> 3-oxoisopentadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47855", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O <=> a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-917841", "l": "Acidification of Tf:TfR1 containing endosome (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35193", "l": "H2O + norsolorinic acid => noranthrone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664214", "l": "ATP2B1 (PMCA1) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22305", "l": "a ubiquinone + keto-D-fructose => 5-dehydro-D-fructose + a ubiquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44565", "l": "4-hydroxybenzoate + all-trans-decaprenyl diphosphate => 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676595", "l": "TRAFs bind RANK:RANKL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46724", "l": "(2S)-2-methyltetradecanoyl-CoA = (2R)-2-methyltetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52761", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O => (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22340", "l": "3-hydroxybenzyl alcohol + NADP(+) = 3-hydroxybenzaldehyde + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.97", "l": "\"3-hydroxybenzyl-alcohol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0032138", "l": "single base insertion or deletion binding", "d": ["Binding to a double-stranded DNA region containing a single base insertion or deletion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940100", "l": "CDK1 phosphorylates VCPIP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11667", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate <=> 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23505", "l": "adenosylcob(III)inamide + H2O => (R)-1-aminopropan-2-ol + adenosylcob(III)yrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73999", "l": "dimethylallyl diphosphate + quinolinone B = diphosphate + peniprequinolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607736", "l": "MALT1 oligomerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46571", "l": "5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52500", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35312", "l": "3-hydroxyisoheptadecanoyl-CoA + NADP(+) => 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52459", "l": "testosterone + UDP-alpha-D-glucuronate <=> H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64126", "l": "hexadecanoate + L-phenylalanine => H2O + N-hexadecanoyl-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.3.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209566", "l": "TRAF6 is auto-ubiquitinated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52198", "l": "1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12231", "l": "ATP + H2O + L-aspartate + L-glutamine <=> AMP + diphosphate + H(+) + L-asparagine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54136", "l": "cytidine(48) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29224", "l": "menaquinone-8 + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0001791", "l": "IgM binding", "d": ["Binding to an immunoglobulin of the IgM isotype."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733292", "l": "AMY1-3 bind pramlintide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60477", "l": "2 ATP + GTP => 3',3',3'-cAAG + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21605", "l": "styrene oxide => 2-phenylacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9696271", "l": "RND1 binds effectors (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38909", "l": "(R)-laudanine + H(+) + S-adenosyl-L-homocysteine => (R)-reticuline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61776", "l": "rebaudioside D + UDP-alpha-D-glucose = H(+) + rebaudioside M + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61402", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine => ATP + N(6)-(D-ribulosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950740", "l": "CANX dissociates from IL12A:EBI3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050301", "l": "streptomycin-6-phosphatase activity", "d": ["Catalysis of the reaction: H2O + streptomycin 6-phosphate = phosphate + streptomycin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8980691", "l": "RHOA GEFs activate RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004965", "l": "G protein-coupled GABA receptor activity", "d": ["Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693593", "l": "D-loop extension by DNA polymerases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56702", "l": "3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate => (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194678", "l": "CYP51A1 demethylates LNSOL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18891", "l": "alpha,alpha-trehalose 6-phosphate + H(+) + UDP => D-glucose 6-phosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76076", "l": "a dicarboxylate(in) + L-erythro-7,8-dihydrobiopterin(out) => a dicarboxylate(out) + L-erythro-7,8-dihydrobiopterin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66763", "l": "ATP + H2O + kainate(in) <=> ADP + H(+) + kainate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51516", "l": "(R)-reticuline + S-adenosyl-L-methionine = (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182990", "l": "Sprouty sequesters CBL away from active EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.45", "l": "\"memapsin 1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67272", "l": "1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + 9-hydroxy-(10E,12Z)-octadecadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60624", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O = 2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18041", "l": "2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin] = 8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.7.7.1", "l": "\"ferredoxin--nitrite reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19103", "l": "4-hydroxy-2-butynal + H(+) + NADH => 2-butyne-1,4-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008431", "l": "vitamin E binding", "d": ["Binding to a vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67000", "l": "2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + phlorisobutanophenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189062", "l": "lactose + H2O => D-glucose + D-galactose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804100", "l": "HMGB1 binds LPS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015654", "l": "tellurite transmembrane transporter activity", "d": ["Enables the transfer of tellurite from one side of a membrane to the other. Tellurite is a salt of tellurous acid or an oxide of tellurium which occurs sparingly in tufts of white or yellowish crystals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34958", "l": "5-(methylsulfanyl)-D-ribose(in) <=> 5-(methylsulfanyl)-D-ribose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033973", "l": "dCTP deaminase (dUMP-forming) activity", "d": ["Catalysis of the reaction: dCTP + 2 H2O = diphosphate + dUMP + H+ + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169406", "l": "ISGylation of host proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0099099", "l": "G-protein gated monoatomic ion channel activity", "d": ["An ion channel activity that is gated by binding of a G-protein beta-gamma dimer."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53363", "l": "5,6-dihydrouridine(47) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(47) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.243", "l": "\"toluene 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156923", "l": "Hydrolysis of eEF1A:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30538", "l": "biotinate sulfoxide + H(+) + NADPH <=> biotin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140842", "l": "n fibrin monomers -> fibrin multimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63055", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32255", "l": "meso-2,6-diaminoheptanedioate + NADP(+) = (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018859", "l": "4-hydroxybenzoate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380949", "l": "AMPK is dephosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55317", "l": "3 H2O + hydrogen sulfide + 3 NAD(+) => 4 H(+) + 3 NADH + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36275", "l": "H(+) + NADPH + O2 + theophylline = 3-methylxanthine + formaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20853", "l": "ATP + H(+)(in) + H2O => ADP + 2 H(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863727", "l": "STON2 is neddylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46298", "l": "6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821410", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686015", "l": "Nsp3, nsp4, and nsp6 produce replicative organelles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9704248", "l": "CHRM4 binds CHRM4 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27380", "l": "(R)-glycerate + ATP <=> (2R)-2-phosphoglycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034738", "l": "lanosterol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + lanosterol = CoA + lanosterol ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60019", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquisabinene B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53720", "l": "ATP + N-acetyl-D-muramate = ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate", "d": []}, {"i": "EC:2.7.1.221", "l": "\"N-acetylmuramate 1-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390649", "l": "CHRM1,3,5 bind acetylcholine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11612", "l": "H2O + L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034513", "l": "box H/ACA snoRNA binding", "d": ["Binding to a box H/ACA small nucleolar RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-706479", "l": "TAK1 is activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018448", "l": "hydroxymethylmethylsilanediol oxidase activity", "d": ["Catalysis of the reaction: hydroxymethylmethylsilanediol + O2 + 2 H+ + 2 e- = formylmethylsilanediol + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53275", "l": "5-dehydro-L-gluconate <=> keto-D-tagaturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690740", "l": "CD22 binds B-cell receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004506", "l": "squalene monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + squalene = (S)-2,3-epoxysqualene + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34389", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP => beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35410", "l": "H2O + medicarpin <=> 4'-methoxyisoflavan-2',4,7-triol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37561", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14506", "l": "2 glutathione + thiosulfate => glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30845", "l": "formate + H(+) + maleamate => H2O + N-formylmaleamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64628", "l": "acetyl-CoA + octan-1-ol = CoA + octyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12538", "l": "CO2 + H2O + L-phenylalanine => H(+) + L-arogenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34511", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP", "d": []}, {"i": "EC:2.4.1.290", "l": "\"N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28168", "l": "5-nitrosalicylate + NH4(+) => 5-nitroanthranilate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2247513", "l": "STAB1:ligand is endocytosed (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64662", "l": "a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate => a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690785", "l": "BAP1 binds Ub-HCFC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.49", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55439", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22756", "l": "a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25807", "l": "H2O + O2 + spermine <=> 3-aminopropanal + H2O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29793", "l": "ADP + glutathione(in) + H(+) + phosphate => ATP + glutathione(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110440", "l": "Autophosphorylation of DINR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033785", "l": "heptose 7-phosphate kinase activity", "d": ["Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-beta-D-heptose-1,7-bisphosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45615", "l": "H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24268", "l": "2,6-dioxo-6-phenylhexanoate + NADP(+) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.40", "l": "\"2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41589", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52135", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O <=> a 5'-end 5'-monophospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806957", "l": "MET receptor dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36667", "l": "(15Z)-tetracosenoyl-CoA + sphinganine = CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873919", "l": "Phosphorylation of JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199558", "l": "KIR2DL1 interacting with HLA-C group 2 (Cw3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18545", "l": "2-dehydro-3-deoxy-L-arabinonate = glycolaldehyde + pyruvate", "d": []}, {"i": "EC:4.1.2.18", "l": "\"2-dehydro-3-deoxy-L-pentonate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54305", "l": "n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate => n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937177", "l": "AHR:TCDD binds ARNT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654571", "l": "Activated FGFR1 binds FRS3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863727", "l": "STON2 is neddylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51919", "l": "(2S)-2-amino-3-butenoate + H2O <=> 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65112", "l": "2-oxoglutarate + aculene D + O2 = aculene C + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35438", "l": "cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose <=> cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17032", "l": "(S)-allantoin + H2O <=> allantoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36055", "l": "a 2-amino-4-hydroxypteridine + H(+) + H2O = a 2,4-dihydroxypteridine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39980", "l": "(+-)-pavine + S-adenosyl-L-methionine => H(+) + N-methylpavine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66942", "l": "12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B => acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45178", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55656", "l": "2 A + a carotenoid beta-end derivative = a carotenoid chi-end derivative + 2 AH2", "d": []}, {"i": "EC:1.3.99.40", "l": "\"carotenoid chi-ring synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41173", "l": "2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+) => 1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12165", "l": "3'-phosphoadenylyl sulfate + a phenol => adenosine 3',5'-bisphosphate + an aryl sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42780", "l": "adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.183", "l": "\"18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613210", "l": "EGR1, EGR2 bind the RRAD promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61339", "l": "ATP + H2O + protoporphyrin IX(in) <=> ADP + H(+) + phosphate + protoporphyrin IX(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013159", "l": "CDC42 GEFs activate CDC42 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73757", "l": "Binding of RRN3 to RNA Polymerase I (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65956", "l": "ATP + estrone 3-sulfate(out) + H2O = ADP + estrone 3-sulfate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099130", "l": "estrogen binding", "d": ["Binding to an estrogen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19689", "l": "L-rhamnulose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate", "d": []}, {"i": "EC:4.1.2.19", "l": "\"rhamnulose-1-phosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199839", "l": "AKT can phosphorylate RSK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55538", "l": "a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+) => an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705926", "l": "AR binds AR agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660660", "l": "p300 acetylates RELA subunit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53440", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13175", "l": "H(+) + NADH + phosphate => H2O + NAD(+) + phosphonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54701", "l": "4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466831", "l": "A2PE hydrolyses to A2E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252133", "l": "ATP6AP1 binds V-ATPase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086060", "l": "voltage-gated sodium channel activity involved in AV node cell action potential", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62992", "l": "H2O + tetradecamide = NH4(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66551", "l": "3'-phosphoadenylyl sulfate + 4-nitrophenol <=> 4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45544", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53737", "l": "a 2-halobenzoate + H(+) + NADH + O2 => a halide anion + catechol + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110011", "l": "Binding of Grb10 to the insulin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001860", "l": "complement component C3d receptor activity", "d": ["Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693347", "l": "CRYM reduces P2C to PPCA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57311", "l": "CTP + H(+) + N(5)-phospho-L-glutamine <=> diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54897", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate + ATP + CoA => (10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16563", "l": "hopan-22-ol => H2O + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59023", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69357", "l": "H(+) + hypobromite + L-tyrosyl-[protein] => 3-bromo-L-tyrosyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62343", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) <=> (+)-malbrancheamide C + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770119", "l": "Formation of the Spliceosomal E complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57209", "l": "glyoxal + L-cysteinyl-[protein] => S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174235", "l": "Association of Emi1 with Cdc20 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45985", "l": "3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25119", "l": "(S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+) => H2O + L-lysine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43132", "l": "N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11533", "l": "glycine + H2O + O2 => glyoxylate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106266", "l": "3-chloro THPH synthase activity", "d": ["Catalysis of the reaction: 2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H+ + 2 H2O."]}, {"i": "RHEA:64356", "l": "2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69348", "l": "S-1-propenyl-L-cysteine sulfoxide = (E)-prop-1-en-1-SO-peroxol + 2-aminoprop-2-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864433", "l": "TFAP2A,TFAP2C homodimers stimulate CGA gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.98.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75928", "l": "cyclohexylamine + H2O + NAD(+) => cyclohexanone + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004608", "l": "phosphatidylethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H+ + phosphatidyl-N-methylethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35608", "l": "acetoin + NADP(+) => diacetyl + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75513", "l": "CoA + H(+) + N-acetyl-S-benzyl-L-cysteine => acetyl-CoA + S-benzyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700168", "l": "Active ALK phosphorylates IRS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0008907", "l": "integrase activity", "d": ["Catalysis of the integration of one DNA segment into another."]}, {"i": "REACT:R-HSA-164523", "l": "Transesterification to connect viral DNA 3' ends to host DNA 5' ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848818", "l": "PTK6 phosphorylates CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39886", "l": "dTDP-6-deoxy-alpha-D-allose + NADP(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25686", "l": "H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) = L-cysteinyl-tRNA(Cys) + phosphate", "d": []}, {"i": "EC:2.5.1.73", "l": "\"O-phospho-L-seryl-tRNA:Cys-tRNA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25376", "l": "a 2-hydroxy-3-methyl fatty acyl-CoA => a 2-methyl-branched fatty aldehyde + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67957", "l": "(S)-2-chloropropanoate + H2O => (R)-lactate + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856157", "l": "LAG3 (CD233) binds MHC II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38308", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68763", "l": "3 (R)-3-phenyllactate + (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022C + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71435", "l": "an aromatic L-alpha-amino acid(in) + L-thyroxine(out) = an aromatic L-alpha-amino acid(out) + L-thyroxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59799", "l": "dodecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] <=> CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72151", "l": "estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871227", "l": "RET binds GFRA4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2203480", "l": "COLEC11 binds ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43838", "l": "26-hydroxycholesterol + H2O + NADP(+) => cholesterol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0052671", "l": "geranylgeraniol kinase activity", "d": ["Catalysis of the reaction: geranylgeraniol + nucleoside triphosphate = all-trans-geranyl-geranyl monophosphate + nucleoside diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53355", "l": "5,6-dihydrouridine(20b) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20b) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69755", "l": "(2-aminobenzyl)malonyl-CoA + H(+) + O2 = (E)-2-aminocinnamoyl-CoA + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030881", "l": "beta-2-microglobulin binding", "d": ["Binding to beta-2-microglobulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25884", "l": "carbamoyl phosphate + N(2)-succinyl-L-ornithine = H(+) + N(2)-succinyl-L-citrulline + phosphate", "d": []}, {"i": "EC:2.1.3.11", "l": "\"N-succinylornithine carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31032", "l": "2-cis-(+)-abscisate + UDP-alpha-D-glucose => beta-D-glucopyranosyl cis-(+)-abscisate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68257", "l": "L-cystine(in) + Na(+)(in) => L-cystine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48196", "l": "H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18005", "l": "D-threitol + NADP(+) = D-erythrulose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.162", "l": "\"erythrulose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696323", "l": "CNRs bind CNR agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659755", "l": "Defective SLC6A18 does not transport Gly from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55224", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61077", "l": "(-)-minovincinine + acetyl-CoA => (-)-echitovenine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632386", "l": "TP63/TP53 stimulates transcription of DDIT4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804596", "l": "APAF1:CYCS binds APIP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730843", "l": "Phosphorylation of LAT by p-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27309", "l": "A + D-proline <=> 1-pyrroline-2-carboxylate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31537", "l": "(S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate => 2-oxoglutarate + L-arginine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43231", "l": "L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004914", "l": "interleukin-5 receptor activity", "d": ["Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018814", "l": "RHOT1 hydrolyzes GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.52", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20561", "l": "3-hydroxypyruvate + H(+) = CO2 + glycolaldehyde", "d": []}, {"i": "EC:4.1.1.40", "l": "\"hydroxypyruvate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203774", "l": "Interaction of Csk with PAG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909720", "l": "IFN alpha/beta binds to IFNAR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043796", "l": "glyceraldehyde dehydrogenase (NADP) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57473", "l": "(E)-4-coumarate + UDP-alpha-D-glucose => 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110213", "l": "NTHL1 glycosylase mediated recognition and binding of formamidopyrimidine (FapyA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373342", "l": "CX3CR1 binds CX3CL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9660192", "l": "VDR agonists bind VDR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176318", "l": "Loading of claspin onto DNA during replication origin firing (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666458", "l": "IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53494", "l": "5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out) => 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10739", "l": "a primary alcohol + NAD(+) <=> an aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10683", "l": "L-proline <=> D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10681", "l": "L-proline => D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47763", "l": "a uridine in 21S rRNA + S-adenosyl-L-methionine <=> a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10167", "l": "(2R)-2-phosphoglycerate <=> H2O + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34883", "l": "ATP + H2O + selenate(out) = ADP + H(+) + phosphate + selenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-982792", "l": "Growth hormone receptor binds JAK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052775", "l": "endo-1,3-alpha-L-rhamnosidase activity", "d": ["Catalysis of the reaction: R1-L-rhamnose-(1->3)-alpha-L-rhamnose-R2 + H2O = R1-L-rhamnose + L-rhamnose-R2. This reaction is the hydrolysis of an alpha-(1->3) linkage between two rhamnose residues in a polysaccharide chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29568", "l": "2 chloride(in) + H(+)(out) => 2 chloride(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676589", "l": "RANKL,sRANKL trimer binds RANK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10022", "l": "(S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH => H2O + L-saccharopine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31662", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3134800", "l": "STING dimerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31094", "l": "acetyl-CoA + dodecanoyl-CoA <=> 3-oxotetradecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50955", "l": "7-chloro-L-tryptophan + AH2 + O2 <=> A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14135", "l": "16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139920", "l": "Translocation of tBID to mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675206", "l": "PEA15 binds MAPK monomers and dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.286", "l": "\"isocitrate--homoisocitrate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28865", "l": "H(+)(in) + lactose(out) => H(+)(out) + lactose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445079", "l": "Phosphorylation of L1 by ERK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433506", "l": "Phosphorylation of APS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62359", "l": "8-oxo-GDP + H2O <=> 8-oxo-GMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73806", "l": "AIR + CO2 => CAIR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68418", "l": "(2R,3S)-iso(homo)2citrate => cis-(homo)2aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63589", "l": "prunetin + UDP-alpha-D-glucuronate => prunetin-4'-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22156", "l": "GDP + H2O = GMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39752", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75603", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = plasmodiophorol A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602316", "l": "Defective MyD88 does not oligomerize within the complex of activated TLR5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15374", "l": "columbamine + S-adenosyl-L-methionine => H(+) + palmatine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839065", "l": "Phosphorylation of cytosolic FGFR1 fusion dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607734", "l": "PKC-delta translocates to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29062", "l": "2 H(+)(in) + H2 + ubiquinone-8 <=> 2 H(+)(out) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27311", "l": "naphthalene-1,2-diol + O2 => 2-hydroxychromene-2-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000286", "l": "alanine dehydrogenase activity", "d": ["Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067659", "l": "Assembly of hexameric IL-6 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60450", "l": "glycine + S-substituted gamma-glutamyl-L-cysteine => an S-substituted glutathione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13496", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57185", "l": "L-cysteinyl-[protein] + methylglyoxal => S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668735", "l": "RAC1:GTP binds NOX3 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199456", "l": "PTEN dephosphorylates PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103116", "l": "ABC-type D-galactofuranose transporter", "d": ["Catalysis of the reaction: alpha-D-galactofuranose + ATP + H2O <=> alpha-D-galactofuranose + hydrogenphosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196929", "l": "FLAD1 phosphorylates FMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39092", "l": "(2E)-decenedioyl-CoA + H2O => (3S)-hydroxydecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170986", "l": "Ral-GDS binds to Ras-GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654224", "l": "Activated FGFR3 binds PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49638", "l": "H(+) + H2O2 + pyruvate => H2O + methylglyoxal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28404", "l": "ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400046", "l": "L-type Calcium Channels close in pancreatic beta cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25712", "l": "L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420131", "l": "The PACAP receptor binds PACAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.20", "l": "\"methylenetetrahydrofolate reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624272", "l": "MMPs cleave HB-EGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69204", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + L-glutamate = ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66380", "l": "ATP + glutathione(in) + glycodeoxycholate(in) + H2O = ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10191", "l": "acetoacetyl-CoA + acetyl-CoA + H2O <=> (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050132", "l": "N-methylalanine dehydrogenase activity", "d": ["Catalysis of the reaction: N-methyl-L-alanine + H2O + NADP+ = H+ + methylammonium + NADPH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614460", "l": "Dimerization of procollagen type VI (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61678", "l": "AMP + H(+) + L-cysteinyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-cysteinyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706393", "l": "RHOBTB3 binds ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46185", "l": "ATP + CoA + isovalerate => 3-methylbutanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55386", "l": "6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40438", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55800", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acyleicosasphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453200", "l": "SYK autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43764", "l": "ATP + chenodeoxycholate + CoA = AMP + chenodeoxycholoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614271", "l": "Autocleavage of ADGRG6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.-.-", "l": "\"Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42667", "l": "alpha-L-arabinopyanose + NADP(+) <=> H(+) + L-arabinono-1,4-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196773", "l": "COASY phosphorylates DP-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57237", "l": "GMP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11053", "l": "4-aminobenzoate + 2 H(+) + NADH + O2 => 4-aminophenol + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32662", "l": "(6E)-8-hydroxygeraniol + 2 NADP(+) <=> (6E)-8-oxogeranial + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73058", "l": "estrone 3-sulfate(out) + hydrogencarbonate(in) <=> estrone 3-sulfate(in) + hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12578", "l": "(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444859", "l": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65902", "l": "glycine + H2O + xanthurenate => 3-hydroxy-L-kynurenine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098750", "l": "FYXD domain binding", "d": ["Binding to a FXYD domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54707", "l": "N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201717", "l": "CSNK2-mediated phosphorylation of DVL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804229", "l": "JMY, TTC5 and EP300 bind (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530565", "l": "iC3b proteolysis (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50633", "l": "a 2-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0015373", "l": "monoatomic anion:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic anion(out) + Na+(out) = monoatomic anion(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23154", "l": "a ubiquinol + NAD(+) => a ubiquinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665871", "l": "ADRM1 binds 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19860", "l": "a 16alpha-hydroxysteroid + NADP(+) <=> a 16-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002440", "l": "Removal of fibrillar collagen C-propeptides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228943", "l": "Transcytosis and dissociation of botA:NTNHA:HA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404193", "l": "IGF1R phosphorylates SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382056", "l": "Crk binds to the active PDGF receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33049", "l": "(+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin] => (1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229343", "l": "AXIN is phosphorylated in the destruction complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12192", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate", "d": []}, {"i": "EC:4.2.3.166", "l": "\"(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15143", "l": "4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin] => 4-methylphenol + H2O + 4 oxidized [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10433", "l": "2-(acetamidomethylene)succinate + H(+) + 2 H2O => acetate + CO2 + NH4(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21594", "l": "H(+) + L-2-aminopentanoate + NADH + pyruvate => (2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3790130", "l": "Regulation of IL6 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74592", "l": "(+)-exo-beta-bergamotene + 3 O2 + 2 reduced [NADPH--hemoprotein reductase] => 5-dehydro-6-demethoxyfumagillol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32826", "l": "phosphate(in) <=> phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768950", "l": "NPAS4 binds FOS gene enhancer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198508", "l": "MDH1 oxidizes MAL to OA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20329", "l": "ATP + L-seryl-[low-density-lipoprotein receptor] = ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor]", "d": []}, {"i": "EC:2.7.11.29", "l": "\"[low-density-lipoprotein receptor] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67010", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56070", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47960", "l": "H2O + N(tele)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18853", "l": "NAD(+) + tartrate = 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.6", "l": "\"alanine carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9823816", "l": "OPTN binds CASP8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2509838", "l": "ITPA hydrolyses dITP to dIMP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41830", "l": "(2E)-hexenoyl-[ACP] + H2O => (3R)-hydroxyhexanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57590", "l": "(2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109700", "l": "AKT2 binds PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58202", "l": "6-oxohexanoate + L-glutamate => 2-oxoglutarate + 6-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47465", "l": "(3E,5Z)-tetradecadienoyl-CoA => (2E,5Z)-tetradecadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48547", "l": "[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine <=> [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997381", "l": "TDPK phosphorylates ThDP to ThTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018334", "l": "Estrogen-responsive CXXC5 gene expresion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33193", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA => a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15250", "l": "3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose => 1-O-galloyl-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72882", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate <=> NH4(+) + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42115", "l": "(20S)-hydroxypregn-4-en-3-one + NADP(+) <=> H(+) + NADPH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69027", "l": "H(+) + N-hydroxy-L-aspartate + NADPH + O2 <=> H2O + N,N-dihydroxy-L-aspartate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55873", "l": "anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) => 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13224", "l": "(R)-mevalonate + NAD(+) <=> H(+) + mevaldate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351876", "l": "Caspase-mediated cleavage of occludin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33018", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 <=> [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75659", "l": "(11Z,14Z)-eicosadienoate + O2 = 12-hydroperoxy-(10E,14Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.67", "l": "\"thiopurine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48778", "l": "19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111883", "l": "Hydrolysis of phosphatidylcholine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32308", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => H2O + leukotriene A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396007", "l": "IRF3 is phosphorylated by TBK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51697", "l": "desmethylxanthohumol + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + xanthohumol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44218", "l": "12-hydroxyoctadecanoyl-CoA + AMP + diphosphate => 12-hydroxyoctadecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52418", "l": "CO2 + dihydroxyacetone phosphate => 3-dehydro-4-O-phospho-D-erythronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23747", "l": "2-oxoglutarate + L-histidinol phosphate <=> 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191784", "l": "snRNA Cap hypermethylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28074", "l": "(2R)-3-sulfopropanediol + H2O + 2 NAD(+) = (2R)-3-sulfolactate + 3 H(+) + 2 NADH", "d": []}, {"i": "EC:1.1.1.308", "l": "\"sulfopropanediol 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904854", "l": "proteasome core complex binding", "d": ["Binding to a proteasome core complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35637", "l": "an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP => an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-452108", "l": "Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11820", "l": "diphthamide-[translation elongation factor 2] + NAD(+) = H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide", "d": []}, {"i": "EC:2.4.2.36", "l": "\"NAD(+)--diphthamide ADP-ribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66453", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+) => 1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047510", "l": "(S)-2-methylmalate dehydratase activity", "d": ["Catalysis of the reaction: S-citramalate = H2O + mesaconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038198", "l": "auxin receptor activity", "d": ["Combining with auxin and transmitting the signal in the cell to initiate a change in cell activity. Auxin is a plant hormone (phytohormone)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034909", "l": "6-hydroxypseudooxynicotine dehydrogenase activity", "d": ["Catalysis of the reaction: 6-hydroxypseudooxynicotine + H2O + OH- = 6-hydroxy-3-succinoylpyridine + 4 H+ + 4 e- + methylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43617", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-593685", "l": "Netrin-4 binds DCC/UNC5A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733545", "l": "Bile salts and acids bind ALB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030059", "l": "aralkylamine dehydrogenase (azurin) activity", "d": ["Catalysis of the reaction: an aralkylamine + H2O + 2 oxidized [azurin] = an aromatic aldehyde + 2 H+ + NH4+ + 2 reduced [azurin]."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008656", "l": "cysteine-type endopeptidase activator activity involved in apoptotic process", "d": ["Binds to and increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52917", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15147", "l": "alpha,alpha-trehalose => D-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983194", "l": "Kinesin-1 is a heterotetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42887", "l": "(R)-mevalonate + ATP <=> (R)-3-phosphomevalonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69718", "l": "(indol-3-yl)acetate + ATP + CoA <=> (indol-3-yl)acetyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60475", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> (6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58107", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944262", "l": "Association of procollagen type X (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670413", "l": "JAK2 binds to p-KIT mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097030", "l": "CENP-A containing nucleosome binding", "d": ["Binding to a centromere-specific nucleosome, a form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193641", "l": "IKK-beta is recruited (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36278", "l": "H(+) + NADPH + O2 + theophylline <=> 3-methylxanthine + formaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851038", "l": "BTN3A1 binds prenylated phosphoantigens (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56046", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15108", "l": "kaempferol + S-adenosyl-L-methionine <=> H(+) + kaempferide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59702", "l": "D-cellopentaonate + H(+) => D-cellopentaono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419389", "l": "LPA-binding receptors bind LPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.693601310289957", "identifiers": [{"i": "GO:0008757", "l": "S-adenosylmethionine-dependent methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71797", "l": "(R)-3-hydroxybutanoate(in) + H(+)(in) => (R)-3-hydroxybutanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72103", "l": "Formation of pre-mRNPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52150", "l": "an aliphatic (Z)-desulfo-glucosinolate + UDP => a (Z)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735302", "l": "GATA4, GATA6, and ISL1:LDB1 bind the HAND2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70447", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + O2 = a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35630", "l": "delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose <=> delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.49", "l": "\"omptin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130504", "l": "Cleavage of lip22 to lip10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31327", "l": "1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol = bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.34", "l": "\"CDP-L-myo-inositol myo-inositolphosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029468", "l": "Conversion of PA into DAG by PAP-1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45865", "l": "16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39702", "l": "(R)-3-hydroxy-(13Z)-eicosenoyl-CoA <=> (2E,13Z)-eicosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76096", "l": "(11R)-19-oxocarlactone + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-carlactonoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68897", "l": "4-hydroxybenzoate + ATP + H(+) + NADPH => 4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75282", "l": "an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-medium-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42132", "l": "isonocardicin C = nocardicin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12907", "l": "GDP-alpha-D-mannose + phosphate => alpha-D-mannose 1-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813740", "l": "GDE1 hydrolyzes GroPIns (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033918", "l": "kappa-carrageenase activity", "d": ["Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55817", "l": "a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13802", "l": "3 H2O + hydrogen sulfide + 3 NADP(+) => 4 H(+) + 3 NADPH + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44914", "l": "(3E)-hexenoyl-CoA + NADP(+) => (2E,4E)-hexadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10802", "l": "5-phospho-alpha-D-ribose 1-diphosphate + xanthine => diphosphate + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25672", "l": "H(+) + loliose + UDP => sucrose + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634228", "l": "TRAF1 is cleaved by caspases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696547", "l": "STAMBPL1 is a deubiquitinase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47919", "l": "ATP + N-hexanoyl-(4R)-hydroxysphinganine <=> ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.240853996207278", "identifiers": [{"i": "GO:0008234", "l": "cysteine-type peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-179417", "l": "Multiubiquitination of Nek2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674022", "l": "BRAP autoubiquitinates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53392", "l": "2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] = (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.54", "l": "\"phenylacetate 2-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0035515", "l": "oxidative RNA demethylase activity", "d": ["Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms."]}, {"i": "REACT:R-HSA-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71101", "l": "androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in) => androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050266", "l": "rosmarinate synthase activity", "d": ["Catalysis of the reaction: caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420688", "l": "GABAB heterodimeric receptor binds GABA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983307", "l": "IL15 binds IL15RA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62523", "l": "a cytidine in rRNA + S-adenosyl-L-methionine <=> an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028524", "l": "NR1H3, NRIP1 bind the PCK1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64487", "l": "acetyl-CoA + 6 H(+) + holo-[ACP] + 6 malonyl-CoA <=> 3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033897", "l": "ribonuclease T2 activity", "d": ["Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754964", "l": "ADA deamidates RBV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31663", "l": "2-oxoglutarate + UDP-N-acetylbacillosamine = L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}, {"i": "EC:2.6.1.34", "l": "\"UDP-N-acetylbacillosamine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70742", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050269", "l": "coniferyl-aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30980", "l": "A + all-trans-lycopene => AH2 + all-trans-3,4-didehydrolycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49107", "l": "Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13096", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39006", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804035", "l": "N2O3 diffuses to phagosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13665", "l": "GTP = 3',5'-cyclic GMP + diphosphate", "d": []}, {"i": "EC:4.6.1.2", "l": "\"guanylate cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0019136", "l": "deoxynucleoside kinase activity", "d": ["Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67343", "l": "malonyl-CoA + quercetin 3-O-beta-D-glucoside <=> CoA + quercetin 3-O-(6-O-malonyl-beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69091", "l": "butanal + H2O + NAD(+) <=> butanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32287", "l": "(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate", "d": []}, {"i": "EC:4.2.1.33", "l": "\"3-isopropylmalate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706399", "l": "RHOBTB3 hydrolyzes ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008518", "l": "folate:monoatomic anion antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Folate derivative (out) + anion (in) = folate derivative (in) + anion (out). The Reduced Folate Carrier (RCF(SLC19A1) acts by an antiport mechanism. RCF carries several folate derivatives: MTX, PMX, ratitrexed, pralatrexate, 5-methyl THF, and 5-formyl THF."]}, {"i": "TCDB:2.A.48", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31579", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate", "d": []}, {"i": "EC:5.4.4.5", "l": "\"9,12-octadecadienoate 8-hydroperoxide 8R-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4411383", "l": "NLK phosphorylates TCF/LEF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672951", "l": "Inactive RAFs bind YWHAB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27553", "l": "di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate => (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19457", "l": "2-nitrophenol + 2 H(+) + 2 NADPH + O2 = catechol + H2O + 2 NADP(+) + nitrite", "d": []}, {"i": "EC:1.14.13.31", "l": "\"2-nitrophenol 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030506", "l": "ankyrin binding", "d": ["Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16461", "l": "ATP + H2O + urate(in) = ADP + H(+) + phosphate + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13440", "l": "(E)-cinnamate + UDP-alpha-D-glucose <=> 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33379", "l": "4-hydroxyeicosasphinganine 1-phosphate + H2O = (4R)-hydroxyeicosasphinganine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781897", "l": "USP11 deubiquitinates NFKBIA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48571", "l": "3-chlorocatechol + O2 <=> (2E,4Z)-2-chloromuconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51545", "l": "D-ribulose => D-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222546", "l": "AP-1 complex stimulates KDM6B transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51153", "l": "2 a thiol + L-cysteinyl-[sulfatase] + O2 => 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53578", "l": "20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44072", "l": "1-O-alkyl-2-acyl-sn-glycerol + ATP = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38813", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33485", "l": "CoA + ergosteryl ester => an acyl-CoA + ergosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864577", "l": "TFAP2C translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14811", "l": "anisole + H(+) + S-adenosyl-L-homocysteine => phenol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20941", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803437", "l": "TP53 stimulates ZNF385A transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20807", "l": "2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) <=> H(+) + hydrogencarbonate + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59300", "l": "3'-phosphoadenylyl sulfate + firefly D-luciferin = adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31319", "l": "(2R)-3-phosphoglycerate + UDP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163568", "l": "phosphorylated perilipin + H2O -> perilipin + orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54105", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21715", "l": "L-threo-3-phenylserine <=> benzaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47405", "l": "(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) => 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.98.2", "l": "\"dichlorochromopyrrolate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015531", "l": "citrate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + H+(out) = citrate(in) + H+(in)."]}, {"i": "RHEA:32123", "l": "citrate(in) + H(+)(in) = citrate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70696", "l": "chloride(out) + glycine(out) + 3 Na(+)(out) => chloride(in) + glycine(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42206", "l": "11-dehydrocorticosterone + H(+) + NADH => corticosterone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70550", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + UDP-alpha-D-glucose <=> 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429860", "l": "DCP1-DCP2 complex decaps mRNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49400", "l": "H2O + validoxylamine A 7'-phosphate = phosphate + validoxylamine A", "d": []}, {"i": "EC:3.1.3.101", "l": "\"validoxylamine A 7'-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43730", "l": "H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase] => methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12787", "l": "an aldose + H(+) + NADH => an alditol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3247836", "l": "Retromer recycles WLS to the Golgi (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18512", "l": "H(+) + H2O2 + NADH <=> 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357445", "l": "PAK1-3 dimer disassociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42296", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.n4", "l": "\"1-acyl-sn-glycerol-3-phosphate acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694583", "l": "ABHD4 hydrolyses NAPE (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54123", "l": "coelenterazine h + O2 <=> coelenterazine h dioxetanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51484", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392064", "l": "G alpha (z) inhibits adenylate cyclase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16817", "l": "6-phospho-D-gluconate + NADP(+) = 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.49", "l": "\"amine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44873", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42113", "l": "(20S)-hydroxypregn-4-en-3-one + NADP(+) => H(+) + NADPH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36037", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42227", "l": "A + testosterone <=> AH2 + androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70829", "l": "L-arginine(out) + L-lysine(in) => L-arginine(in) + L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54910", "l": "(4E)-hexenoyl-CoA + NADP(+) => (2E,4E)-hexadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102211", "l": "unsaturated rhamnogalacturonyl hydrolase activity", "d": ["Catalysis of the reaction: 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose(1-) + H2O <=> (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + alpha-L-rhamnopyranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-921155", "l": "p-STAT5 dissociates from the receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74570", "l": "L-glutamate(in) + N-acetyl-L-cysteine(out) <=> L-glutamate(out) + N-acetyl-L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22210", "l": "H2O + homogentisate + NAD(+) => 3-hydroxyphenylacetate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41104", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39246", "l": "(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199839", "l": "AKT can phosphorylate RSK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008349", "l": "MAP kinase kinase kinase kinase activity", "d": ["Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73140", "l": "lithocholate(out) => lithocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.11", "l": "\"cholesterol-5,6-oxide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56130", "l": "AH2 + diphosphate + flavuxanthin => A + dimethylallyl diphosphate + H2O + nonaflavuxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11781", "l": "3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.1", "l": "\"exodeoxyribonuclease I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57796", "l": "4-nitrotoluene + NADH + O2 = 4-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090499", "l": "pimelyl-[acyl-carrier protein] methyl ester esterase activity", "d": ["Catalysis of the reaction: pimelyl-[acyl-carrier protein] methyl ester + H2O = pimelyl-[acyl-carrier protein] + methanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34350", "l": "(2E)-geraniol + NAD(+) <=> (2E)-geranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23117", "l": "4-hydroxybenzoate + ATP + CoA => 4-hydroxybenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030629", "l": "U6 snRNA 3'-end binding", "d": ["Binding to a U6 small nuclear RNA (U6 snRNA) at the 3' end."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72320", "l": "n chloride(in) + urate(out) => n chloride(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177284", "l": "PKA phosphorylates PDE4B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983138", "l": "Transport of MHC heterotrimer to ER exit site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35775", "l": "L-glutamine + UDP-3-oxo-alpha-D-glucose = 2-oxoglutaramate + UDP-alpha-D-kanosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75080", "l": "Formation of AT-AC A complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964884", "l": "Dephosphorylation of EPSP yields chorismate (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22820", "l": "3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.2.62", "l": "\"xylosyl alpha-1,3-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38135", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25660", "l": "(R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36280", "l": "H(+) + NADH + O2 + theophylline => 3-methylxanthine + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008504", "l": "monoamine transmembrane transporter activity", "d": ["Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32183", "l": "cholesterol + O2 = cholest-5-en-3-one + H2O2", "d": []}, {"i": "EC:1.1.3.6", "l": "\"cholesterol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23985", "l": "cholesterol + NADP(+) => 7-dehydrocholesterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417842", "l": "P2Y10 receptor can bind to LPA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13176", "l": "H2O + NAD(+) + phosphonate <=> H(+) + NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446364", "l": "Migfilin interacts with VASP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340226", "l": "CYGB dioxygenates NO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031874", "l": "type 3 proteinase activated receptor binding", "d": ["Binding to a type 3 proteinase activated receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33153", "l": "(R)-S(6)-acetyldihydrolipoamide + CoA => (R)-dihydrolipoamide + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21132", "l": "H2O + O2 + xanthine = H2O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58869", "l": "24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120160", "l": "intraciliary transport particle A binding", "d": ["Binding to an intraciliary transport particle A (IFT A) complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37292", "l": "H2O + L-alanyl-L-leucine => L-alanine + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70693", "l": "chloride(in) + glycine(in) + 2 Na(+)(in) => chloride(out) + glycine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26193", "l": "(S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate", "d": []}, {"i": "EC:6.2.1.9", "l": "\"malate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008054", "l": "IL1F10 binds IL1RAPL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46923", "l": "(E)-cinnamate + H(+) <=> CO2 + styrene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696482", "l": "CTF1 binds LIFR:JAKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24593", "l": "CTP + H(+) + phosphoethanolamine => CDP-ethanolamine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74297", "l": "n H(+)(in) + serotonin(out) => n H(+)(out) + serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59361", "l": "carnosine + H2O => beta-alanine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322431", "l": "XIAP binds TLE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5099899", "l": "WNT5A binds FZD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75502", "l": "cholate(out) + n H(+)(out) <=> cholate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69924", "l": "castasterone + O2 + reduced [NADPH--hemoprotein reductase] => brassinolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43319", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114552", "l": "Thrombin-activated PARs activate G12/13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12576", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose = (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.66", "l": "\"procollagen glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14052", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48706", "l": "12S-HpEPE => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341072", "l": "SUMOylation of RARA with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74015", "l": "4-hydroxybenzoate + H(+) + phosphate = CO2 + H2O + phenyl phosphate", "d": []}, {"i": "EC:4.1.1.123", "l": "\"phenyl-phosphate phosphatase/carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16641", "l": "a long-chain fatty acyl ethyl ester + H2O = a long-chain fatty acid + ethanol + H(+)", "d": []}, {"i": "EC:3.1.1.67", "l": "\"fatty-acyl-ethyl-ester synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26062", "l": "Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine <=> methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001083", "l": "alpha-D-glucan binding", "d": ["Binding to alpha-D-glucan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57785", "l": "1,4-dinitrobenzene + NADH + O2 => 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32393", "l": "(1R,4R)-dihydrocarvone + H(+) + NADH => (1R,2R,4R)-dihydrocarveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008671", "l": "2-dehydro-3-deoxygalactonokinase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44781", "l": "2-demethylmenaquinol-9 + S-adenosyl-L-methionine => H(+) + menaquinol-9 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74822", "l": "glutathione(in) <=> glutathione(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74168", "l": "H2O + N,N-dimethylglycine + oxidized 2[4Fe-4S]-[ferredoxin] => formaldehyde + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35583", "l": "2-dehydro-3-deoxy-D-gluconate = D-glyceraldehyde + pyruvate", "d": []}, {"i": "EC:4.1.2.51", "l": "\"2-dehydro-3-deoxy-D-gluconate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57755", "l": "2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45174", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31595", "l": "(Z)-2-methylureidoacrylate + H2O = (Z)-2-methylaminoacrylate + carbamate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803999", "l": "HNO2 produces N2O3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873918", "l": "Transphosphorylation of JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14562", "l": "(E,E)-piperoyl-CoA + piperidine => CoA + H(+) + piperine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64612", "l": "ATP + L-glutamate + tRNA(Gln) = AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15910", "l": "2-oxoglutarate + O2 + taurine => aminoacetaldehyde + CO2 + H(+) + succinate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21001", "l": "1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene => 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68086", "l": "diphosphate + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] => GTP + L-histidyl-[RNA ligase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2464822", "l": "RDH12 reduces atRAL to atROL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114684", "l": "Phosphorylation of Syntaxin-4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171291", "l": "Folding and Oligomerization of ENV glycoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45117", "l": "(4R)-ipsdienol + NADP(+) => H(+) + ipsdienone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047049", "l": "(R)-2-hydroxy-fatty acid dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxystearate + NAD+ = 2-oxostearate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35689", "l": "3-oxotetradecasphinganine + H(+) + NADPH => NADP(+) + tetradecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781814", "l": "USP19 deubiquitinates RNF123 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26380", "l": "GTP <=> cyclic pyranopterin phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37190", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate <=> 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047398", "l": "dolichylphosphate-mannose phosphodiesterase activity", "d": ["Catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.1", "l": "\"non-specific serine/threonine protein kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18022", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) => CMP + ganglioside GD1a (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647680", "l": "CASP1 cleaves GSDMD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0046993", "l": "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is oxygen."]}, {"i": "EC:1.21.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31563", "l": "H2O + leukotriene C4 = L-glutamate + leukotriene D4", "d": []}, {"i": "EC:3.4.19.14", "l": "\"leukotriene-C4 hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237129", "l": "Acireductone is created (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40481", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653180", "l": "GABA translocates from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5260201", "l": "p-AKT2 phosphorylates C2CD5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9609921", "l": "SGTA binds Tail-anchored protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30168", "l": "D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451309", "l": "Edited Kainate Receptor binds glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008684", "l": "TBK1 phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72057", "l": "glycodeoxycholate(in) + 2 Na(+)(in) => glycodeoxycholate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13656", "l": "[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose <=> [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71328", "l": "chloride(out) + L-threonine(out) + 2 Na(+)(out) => chloride(in) + L-threonine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729232", "l": "SARS-CoV-1 nsp1 binds to 40S ribosomal subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.369", "l": "\"enterobactin C-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254251", "l": "ERBB4s80 binds YAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965441", "l": "FZD recruits trimeric G-proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30933", "l": "acetate + H(+) + L,L-cystathionine => L-cysteine + O-acetyl-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374669", "l": "L1 binds NRP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18709", "l": "A + H2O + taurine = AH2 + NH4(+) + sulfoacetaldehyde", "d": []}, {"i": "EC:1.4.99.2", "l": "\"taurine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58958", "l": "a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine => a ribonucleotide in RNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16971", "l": "dTDP-4-dehydro-beta-L-rhamnose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19660", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) <=> CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46244", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043811", "l": "phosphate:acyl-[acyl carrier protein] acyltransferase activity", "d": ["Catalysis of the reaction: a fatty acyl-[acyl-carrier protein] + orthophosphate = acyl phosphate + [acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12337", "l": "carboxymethoxysuccinate => fumarate + glycolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72872", "l": "anthocyanin A3 + malonyl-CoA => anthocyanin A5 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11604", "l": "[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15141", "l": "4-methylphenol + H2O + 4 oxidized [azurin] = 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]", "d": []}, {"i": "EC:1.17.9.1", "l": "\"4-methylphenol dehydrogenase (hydroxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54976", "l": "(3S)-hydroxytetradecanoyl-CoA + H2O = (3S)-hydroxytetradecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198756", "l": "ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.65", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9017491", "l": "RHOJ GEFs activate RHOJ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66919", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871265", "l": "YAP1 binds TEAD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030754", "l": "apigenin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60867", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58837", "l": "24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102044", "l": "3-chlorobenzoate-4,5-oxygenase activity", "d": ["Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-4,5-diol + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68796", "l": "D-maltose + H2O = alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71402", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin <=> 2alpha-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62348", "l": "H(+) + NADPH + notoamide E + O2 = H2O + NADP(+) + notoamide C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000122", "l": "CD320 binds extracellular TCN2:RCbl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67744", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) + H2O = 1-O-alkyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35800", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O => 7,8-dihydroneopterin 3'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42274", "l": "5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA => 3-methylbutanoyl-CoA + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18539", "l": "2 H(+) + NADH + salicylate => H2O + NAD(+) + salicylaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-349455", "l": "Phosphorylation of MDM4 by ATM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66609", "l": "(tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O => GpCpCpA + H(+) + tRNA 3'-end (ribonucleotide 3'-phosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630047", "l": "Defective NTHL1 truncation mutants do not bind cytosine glycol (Cg) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559439", "l": "CD14:LPS binds CR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29271", "l": "a menaquinol + H(+) + trimethylamine N-oxide = a menaquinone + H2O + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46978", "l": "6-hydroxy-N-methylmyosmine + H2O2 => (S)-6-hydroxynicotine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018766", "l": "RHOU binds effectors at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030739", "l": "O-demethylpuromycin O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784735", "l": "PCSK9:LDLR bind to Clathrin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632039", "l": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2002428", "l": "Removal of fibrillar collagen N-propeptides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50535", "l": "acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730903", "l": "Oligomerization of TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70324", "l": "2,3-dioxo-L-gulonate => 2-carboxy-L-lyxonolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60436", "l": "3-methylbutyl acetate + H2O = 3-methylbutanol + acetate + H(+)", "d": []}, {"i": "EC:3.1.1.112", "l": "\"isoamyl acetate esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22058", "l": "H(+) + hexadecanal + NADH => hexadecan-1-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865275", "l": "PDGF-BB clevage by Furin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9621179", "l": "Cinaciguat binds sGC:NO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15765", "l": "adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805059", "l": "CK2:FACT phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.377", "l": "\"L-rhamnose 1-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977605", "l": "Factor H displaces Bb (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18703", "l": "arsenate + 3 H(+) + 2 reduced [azurin] => arsenite + H2O + 2 oxidized [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17908", "l": "(R)-glycerate + NAD(+) <=> 3-hydroxypyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433454", "l": "Phosphorylation of GAB2 by SFKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49744", "l": "deoxyviolaceinate + H(+) + O2 = CO2 + deoxyviolacein + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759860", "l": "FOXF1 binds the GATA4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66094", "l": "H2O + kynurenate + L-phenylalanine => 3-phenylpyruvate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28333", "l": "H2O + ITP <=> H(+) + IDP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013009", "l": "RHOA binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65611", "l": "(4R)-hydroxysphinganine + docosanoyl-CoA <=> CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849646", "l": "SPINK5(490-624) binds KLK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68272", "l": "a fatty acyl-CoA + L-seryl-[protein] = CoA + O-fatty acyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15918", "l": "an aldopyranose + NAD(+) => aldono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72095", "l": "Internal Methylation of mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047781", "l": "citrullinase activity", "d": ["Catalysis of the reaction: H2O + citrulline = NH3 + CO2 + L-ornithine."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008455", "l": "alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39217", "l": "hexacosanoyl-CoA + NADP(+) => (2E)-hexacosenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863718", "l": "AGFG1 binds VAMP7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379865", "l": "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12581", "l": "H2O + NAD(+) + tauropine => H(+) + NADH + pyruvate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59226", "l": "diphosphate + hydropyrene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168885", "l": "Haptoglobin binds Hemoglobin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903880", "l": "17alpha-hydroxyprogesterone binding", "d": ["Binding to 17alpha-hydroxyprogesterone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72049", "l": "AH2 + fusahexin + 6 H2O => A + D-alanine + D-allothreonine + D-leucine + 2 L-leucine + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54561", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP => a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36923", "l": "(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75444", "l": "heme b(in) => heme b(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64368", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50079", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71239", "l": "2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33837", "l": "(4R)-hydroxysphinganine + hexacosanoate => H2O + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20662", "l": "D-alanyl-D-alanine + H2O => 2 D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097008", "l": "(3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity", "d": ["Catalysis of the reaction: (E)-nerolidol + NADPH + O2 = (3E)-4,8-dimethylnona-1,3,7-triene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C11-geranylacetone and then cleaved to produce (3E)-4,8-dimethylnona-1,3,7-triene (DMNT) and acetone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62495", "l": "ATP + holo-[peptidyl-carrier protein] + L-arginine <=> AMP + diphosphate + L-arginyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41740", "l": "adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.219", "l": "\"tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16925", "l": "(E)-caffeoyl-CoA + S-adenosyl-L-methionine = (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.104", "l": "\"caffeoyl-CoA O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17843", "l": "H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP => trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1237129", "l": "Acireductone is created (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33742", "l": "2 H(+) + hexadecanoate + NADH <=> H2O + hexadecanal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051109", "l": "crotonobetaine-CoA ligase activity", "d": ["Catalysis of the reaction: CoA + crotono-betaine + ATP = AMP + diphosphate + crotonobetainyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371435", "l": "Constitutive phosphorylation by GSK3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008288", "l": "boss receptor activity", "d": ["Combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39910", "l": "2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose <=> dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237102", "l": "Transamination of MOB to methionine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39058", "l": "22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008918", "l": "lipopolysaccharide 3-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373738", "l": "Neurofascin interacts with syntenin-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604675", "l": "NICD4 binds to TACC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40903", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59351", "l": "D-maltobiono-1,5-lactone + H2O <=> D-maltobionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35753", "l": "ADP + D-kanosamine 6-phosphate + H(+) => ATP + kanosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47836", "l": "[5-(aminomethyl)-3-furyl]methyl phosphate + ATP = [5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP", "d": []}, {"i": "EC:2.7.4.31", "l": "\"[5-(aminomethyl)furan-3-yl]methyl phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9818574", "l": "TASP1 cleaves KMT2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25522", "l": "CoA + H(+) + O-acylpseudotropine => an acyl-CoA + pseudotropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12964", "l": "acetoacetate + butanoyl-CoA <=> acetoacetyl-CoA + butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51637", "l": "a quinone + H2O + selenite => a quinol + selenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62446", "l": "H(+) + L-arginine + L-canaline => L-canavanine + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30174", "l": "hexadecanoyl-[ACP] + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50835", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 <=> 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49565", "l": "D-sedoheptulose 7-phosphate => 2-epi-valiolone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31282", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate <=> (2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40975", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = 2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53104", "l": "4-hydroxyestrone + S-adenosyl-L-methionine = 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19627", "l": "acetaldehyde + glycine => L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19506", "l": "indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose => (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9793472", "l": "RIPK3 binds p-S9-PRKN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928617", "l": "EPHB2 binds KALRN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44457", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14719", "l": "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate => D-erythrose 4-phosphate + H2O + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55275", "l": "11-cis-retinol + tetradecanoyl-CoA <=> 11-cis-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696131", "l": "AOC1 deaminates Hist (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951644", "l": "Release of mature NEDD8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697018", "l": "Addition of sialic acids on some Spike glycosyl sidechains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38602", "l": "NADP(+) + nicotinate <=> nicotinamide + nicotinate-adenine dinucleotide phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35549", "l": "2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin] => cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60331", "l": "L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62999", "l": "(8Z,11Z,14Z)-eicosatrienamide + H2O <=> (8Z,11Z,14Z)-eicosatrienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43910", "l": "D-galactose + sphing-4-enine => beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033437", "l": "ACU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an ACU codon."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043875", "l": "2-ketobutyrate formate-lyase activity", "d": ["Catalysis of the reaction: 2-oxobutanoate + coenzyme A = propionyl-CoA + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052731", "l": "phosphocholine phosphatase activity", "d": ["Catalysis of the reaction: choline phosphate + H2O = choline + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33605", "l": "H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+) => H(+) + N-hexacosanoylsphinganine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448632", "l": "IL34 dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806610", "l": "Keratin filament formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029272", "l": "Release of PLCG from FCGR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134946", "l": "DDX41 ubiquitination by TRIM21 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351948", "l": "Mitochondrial recruitment of Drp1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35471", "l": "(+)-6a-hydroxymaackiain + S-adenosyl-L-methionine = (+)-pisatin + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.270", "l": "\"(+)-6a-hydroxymaackiain 3-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25812", "l": "H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008480", "l": "GSK3B phosphorylates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373745", "l": "SDK1 homophillic interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66545", "l": "L-cysteinyl-[protein] + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73973", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+) => a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.63", "l": "\"2-hydroxyacyl-CoA lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12440", "l": "H2O + L-saccharopine + NAD(+) = 2-oxoglutarate + H(+) + L-lysine + NADH", "d": []}, {"i": "EC:1.5.1.7", "l": "\"saccharopine dehydrogenase (NAD(+), L-lysine-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390425", "l": "FAR1 reduces PalmCoA to HXOL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14144", "l": "AMP + glutathione disulfide + 2 H(+) + sulfite <=> adenosine 5'-phosphosulfate + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445699", "l": "ATP Hydrolysis By Myosin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49805", "l": "2-methylpropan-1-amine + FMNH2 + O2 => FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62093", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62933", "l": "H2O + N(4)-acetylcytidine => acetate + cytidine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15142", "l": "4-methylphenol + H2O + 4 oxidized [azurin] => 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008824", "l": "cyanate hydratase activity", "d": ["Catalysis of the reaction: cyanate + H2O = carbamate."]}]}
{"type": "biolink:MolecularActivity", "ic": "49.265787240219524", "identifiers": [{"i": "GO:0015318", "l": "inorganic molecular entity transmembrane transporter activity", "d": ["Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140233", "l": "intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential", "d": ["Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28128", "l": "alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72103", "l": "Formation of pre-mRNPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12040", "l": "(S)-3-(imidazol-5-yl)lactate + NADP(+) = 3-(imidazol-5-yl)pyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170005", "l": "cyclic nucleotide phosphodiesterase activator activity", "d": ["Binds to and increases the activity of cyclic nucleotide phosphodiesterase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213207", "l": "Formation of collagen networks (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19178", "l": "L-lysine => (3S)-3,6-diaminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661980", "l": "F8 variant is not secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61909", "l": "2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol => 2 AMP + asperphenamate + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937792", "l": "RUNX3 binds SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44154", "l": "myo-inositol + phosphate => 1D-myo-inositol 2-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38199", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0005096", "l": "GTPase activator activity", "d": ["Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050129", "l": "N-formylglutamate deformylase activity", "d": ["Catalysis of the reaction: N-formyl-L-glutamate + H2O = L-glutamate + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54247", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674529", "l": "AAMP binds to TBXA2R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029690", "l": "Caspase-6 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45971", "l": "androst-4-ene-3,17-dione + H(+) + NADH + O2 <=> 9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011074", "l": "LHX2 binds to ROBO1 gene locus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198756", "l": "ERK1/2 phosphorylates MSK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33133", "l": "3-phenylpyruvate + tetrahydrotyrosine => L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17709", "l": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9761027", "l": "ZEB2 binds SP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72574", "l": "dehydroepiandrosterone 3-sulfate(in) + pentanoate(out) <=> dehydroepiandrosterone 3-sulfate(out) + pentanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786190", "l": "CMBL hydrolyses OM to OLMS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75285", "l": "10-hydroxydecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => decanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52693", "l": "3-phenyllactate + NADP(+) => 3-phenylpyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507873", "l": "Aquaporins passively transport urea out of cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371467", "l": "SIRT1 deacetylates HSF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140907", "l": "flavin-dependent halogenase activity", "d": ["Catalysis of the reaction: R-CH + a halogen + FADH2 + O2 = R-C-halogen + FAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55102", "l": "(3R)-hydroxypentanoyl-[ACP] + NADP(+) => 3-oxopentanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20179", "l": "5'-O-beta-D-glucosylpyridoxine + H(+) + UDP => pyridoxine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18470", "l": "an acyl-CoA + L-glutamine => an N(2)-acyl-L-glutamine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856525", "l": "ANGPTL8 binds ANGPTL3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47814", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.12", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102030", "l": "dTDP-L-rhamnose synthetase activity", "d": ["Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + NAD+ <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5225649", "l": "RBBP7 binds histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876246", "l": "InlB-activated MET phosphorylates CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140339", "l": "phosphatidylglycerol transfer activity", "d": ["Directly binding to phosphatidylglycerol and delivering it either to an acceptor molecule or to a specific location."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15024", "l": "(E)-feruloyl-CoA + L-quinate <=> 4-O-feruloyl-D-quinate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40322", "l": "O2 + tetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141409", "l": "Mad1 binds kinetochore (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250264", "l": "TXNIP binds reduced thioredoxin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578712", "l": "Importin-8 binds AGO2:miRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848596", "l": "PTK6 binds PXN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31954", "l": "9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28474", "l": "D-glucarate(in) + H(+)(in) = D-glucarate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15262", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140381", "l": "4-hydroxytryptamine 4-phosphate methyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine (SAM) + 4-hydroxytryptamine 4-phosphate (norbaeocystin) <=> 2 S-adenosyl-L-homocysteine + psilocybin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2562526", "l": "PLK1 phosphorylates OPTN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53689", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017161", "l": "inositol-1,3,4-trisphosphate 4-phosphatase activity", "d": ["Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2534240", "l": "HSPG2 (perlecan) degradation by MMP14, MMP15 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51123", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2 <=> (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48957", "l": "[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide => [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672980", "l": "Dissociation of RAS:RAF complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380780", "l": "Activation of Src (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67959", "l": "(S)-2-chloropropanoate + H2O <=> (R)-lactate + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55481", "l": "ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33517", "l": "2 H2O + 2 indole-5,6-quinone => 2 5,6-dihydroxyindole + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1964496", "l": "STING binds TRIM32 or TRIM56  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37457", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68960", "l": "DNA polymerase epsilon binds at the origin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1370500", "l": "PRLR binds SCF beta-TrCP complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0046906", "l": "tetrapyrrole binding", "d": ["Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40636", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75775", "l": "(6Z,9Z,12Z)-octadecatrienoate + H2O = (10S)-hydroxy-(6Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64161", "l": "ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide => ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68314", "l": "1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate => 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804253", "l": "MDM2 ubiquitinates JMY (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047684", "l": "arylamine glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + an arylamine = UDP + an N-D-glucosylarylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23589", "l": "oxalate + succinyl-CoA => oxalyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49838", "l": "(5E)-tetradecenoyl-(R)-carnitine + CoA => (5E)-tetradecenoyl-CoA + (R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11495", "l": "H(+) + O-phospho-L-threonine <=> (R)-1-aminopropan-2-yl phosphate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18302", "l": "ATP + NH4(+) + XMP => AMP + diphosphate + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791235", "l": "GADD45A binds AURKA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36757", "l": "beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209891", "l": "Dopamine is oxidised to noradrenaline (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445714", "l": "Aquaporin-3 passively transports water out of cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67874", "l": "3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54480", "l": "1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16263", "l": "CoA + H(+) + N(6)-succinyl-L-lysyl-[protein] => L-lysyl-[protein] + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004793", "l": "threonine aldolase activity", "d": ["Catalysis of the reaction: L-threonine = glycine + acetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54780", "l": "[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine = [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093332", "l": "p-EPHB phosphorylates SDC2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693478", "l": "HTR1A binds HTR1A agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033898", "l": "Bacillus subtilis ribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage to 2',3'-cyclic nucleotides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67097", "l": "2-oxoglutarate + asnovolin A + 2 O2 => CO2 + fumigatonoid A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38836", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19930", "l": "[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66458", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32513", "l": "(3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+) => (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13460", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H(+) <=> (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10761", "l": "citrate => acetate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40031", "l": "ent-copalyl diphosphate + H2O = diphosphate + ent-manool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68114", "l": "NH4(+) + propanoate => H2O + propanamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-112429", "l": "Formation of FACT complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58904", "l": "8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH = C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40645", "l": "(9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+) => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2984226", "l": "PLK1 phosphorylates NEK9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139898", "l": "Caspase-8 activates BID by cleavage (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33387", "l": "cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine = aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390425", "l": "FAR1 reduces PalmCoA to HXOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0005085", "l": "guanyl-nucleotide exchange factor activity", "d": ["Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31366", "l": "NADP(+) + reduced coenzyme F420-(gamma-L-Glu)(n) <=> 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57378", "l": "(S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38476", "l": "L-histidine + S-adenosyl-L-methionine => H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.5", "l": "\"dissimilatory sulfite reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28560", "l": "D-fructose + phosphate => D-fructose 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42370", "l": "H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase] => dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47380", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341048", "l": "SUMOylation of RXRA with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592362", "l": "Activation of proMMP7 by MMP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36346", "l": "2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 <=> 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72143", "l": "AH2 + GTP + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25254", "l": "ATP + N-acetyl-D-mannosamine => ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451283", "l": "kainate receptor binds glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67243", "l": "(R)-S-adenosyl-L-methionine + H2O <=> adenosine + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218822", "l": "CRK binds BCAR1 and or PXN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43537", "l": "2 D-glyceraldehyde 3-phosphate => 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75071", "l": "chloride(out) + Cs(+)(in) + 2 hydrogencarbonate(in) = chloride(in) + Cs(+)(out) + 2 hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36517", "l": "3-oxohexacosanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58836", "l": "24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67084", "l": "ATP + H2O + hexacosanoate(in) = ADP + H(+) + hexacosanoate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62514", "l": "2-hydroxymelatonin + CO2 + succinate => 2-oxoglutarate + melatonin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797100", "l": "CCNK binds CDK13 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67579", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O <=> [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2509838", "l": "ITPA hydrolyses dITP to dIMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16599", "l": "ADP + CTP + 2 H(+) + phosphate => ATP + NH4(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376122", "l": "DSCAM/DSCAML1 homodimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60437", "l": "3-methylbutyl acetate + H2O => 3-methylbutanol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203979", "l": "Coat Assembly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9676255", "l": "Formation of the MLL2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45669", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39648", "l": "AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373705", "l": "Caspase cleavage of DCC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045483", "l": "aristolochene synthase activity", "d": ["Catalysis of the reaction: trans,trans-farnesyl diphosphate = aristolochene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10918", "l": "all-trans-phytoene + diphosphate => (1R,2R,3R)-prephytoene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218806", "l": "FYN autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68799", "l": "D-maltose + H2O <=> alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15063", "l": "2 a Fe(III)-siderophore + NADH => 2 a Fe(II)-siderophore + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810076", "l": "DDO oxidizes D-Asp to OA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14212", "l": "alpha-D-galactose 1-phosphate + H(+) + UTP <=> diphosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848726", "l": "PTK6 phosphorylates BCAR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35900", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA => 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801101", "l": "RABGGTA binds RABGGTB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2201341", "l": "Endocytosis of TRAM (TICAM2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-844438", "l": "NLRP1 oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016977", "l": "chitosanase activity", "d": ["Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24864", "l": "pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose <=> H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25665", "l": "(2E)-geranyl diphosphate <=> alpha-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59789", "l": "H2O + NAD(+) + pseudopaline => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171011", "l": "Binding and activation of MAP Kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203700", "l": "eNOS translocation from Golgi to Caveolae (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64850", "l": "(3Z)-hex-3-en-1-yl benzoate + CoA => (3Z)-hex-3-en-1-ol + benzoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166168", "l": "TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18288", "l": "an N-acyl-D-aspartate + H2O <=> a carboxylate + D-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797961", "l": "CHDH oxidises Cho to BETALD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59813", "l": "hexadecanoyl-CoA + N-terminal glycyl-[protein] => CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49933", "l": "(3E,5Z)-octadienoyl-CoA => (2E,5Z)-octadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.236", "l": "\"NAD(+) 3'-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354073", "l": "Autophosphorylation of PTK2 at Y397 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102147", "l": "3'-O-methyltricetin O methyl transferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3'-O-methyltricetin = H+ + S-adenosyl-L-homocysteine + 3',5'-di-O-methyltricetin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.-.-", "l": "\"Carbon-sulfur lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38306", "l": "2-amino-2-deoxy-D-gluconate 6-phosphate <=> 2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805507", "l": "APAF1 binds AVEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10930", "l": "ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1980122", "l": "DTX binds NOTCH1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938853", "l": "CDK6 binds RUNX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014454", "l": "RHOG translocates to the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64583", "l": "(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate <=> diphosphate + nerylneryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19453", "l": "2-oxoglutarate + L-alanine = L-glutamate + pyruvate", "d": []}, {"i": "EC:2.6.1.2", "l": "\"alanine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21479", "l": "[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74986", "l": "Elongation of pre-rRNA transcript (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28092", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16788", "l": "an adenosine in tRNA + S-adenosyl-L-methionine <=> an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430096", "l": "GP1b-IX-V binds filamin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40494", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2752115", "l": "SPP1 (osteopontin) binds CD44 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15170", "l": "H2O + N-succinyl-L-glutamate => L-glutamate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32629", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804099", "l": "HMGB1 binds LTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53723", "l": "ATP + N-acetyl-D-muramate <=> ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873919", "l": "Phosphorylation of JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38189", "l": "17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.-", "l": "\"Miscellaneous\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66319", "l": "an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O <=> alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008764", "l": "UDP-N-acetylmuramoylalanine-D-glutamate ligase activity", "d": ["Catalysis of the reaction: D-glutamate + ATP + UDP-N-acetylmuramoyl-L-alanine = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5226979", "l": "ADD1:ADD2 binds DMTN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41748", "l": "3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol = 1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10638", "l": "D-mannuronate + H(+) + NADPH => D-mannonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10315", "l": "H(+) + NADH + O2 + terephthalate <=> (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66800", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11483", "l": "3-hydroxybenzoate + H(+) + NADPH + O2 <=> 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34801", "l": "3-oxo-5,6-didehydrosuberyl-CoA + CoA => 2,3-didehydroadipoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56129", "l": "A + dimethylallyl diphosphate + H2O + nonaflavuxanthin => AH2 + diphosphate + flavuxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44619", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O <=> 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56628", "l": "5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O = chloride + 2 H(+) + maleylacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043778", "l": "cobalt-precorrin-8 methylmutase activity", "d": ["Catalysis of the reaction: cobalt-precorrin 8 = cobyrinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40612", "l": "H2O + trihexanoylglycerol => 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34289", "l": "2 H2O + 2 L-dopaquinone => 2 L-dopa + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389919", "l": "Grb2 binds pBTLA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.42", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27579", "l": "(R)-N-tert-butylpiperazine-2-carboxamide + H2O => (R)-piperazine-2-carboxylate + tert-butylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48687", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O <=> [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31738", "l": "3-oxocholan-24-oyl-CoA + NAD(+) <=> 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72621", "l": "Ribosomal scanning  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35418", "l": "an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose <=> an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66112", "l": "2-oxobutanoate + L-tyrosine = (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050013", "l": "2-dehydropantoate aldolase activity", "d": ["Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696547", "l": "STAMBPL1 is a deubiquitinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40265", "l": "3-oxohexadecanedioyl-CoA + H(+) + NADH => (3R)-hydroxyhexadecanedioyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37819", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31442", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-longipinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664406", "l": "IgG:Lma antigens binds FCGR3A:CD3 dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43287", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40000", "l": "a sphingoid 1-phosphate => a fatty aldehyde + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58451", "l": "N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12548", "l": "2-cis,4-trans-xanthoxin + NAD(+) = 2-cis-(+)-abscisic aldehyde + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.288", "l": "\"xanthoxin dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56082", "l": "[Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+) => [Rab1 protein]-L-serine + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74718", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine <=> 3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37939", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9676264", "l": "Formation of the SET1B complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27838", "l": "9H-carbazole + H(+) + NADH + O2 = 2'-aminobiphenyl-2,3-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41044", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029456", "l": "RAC1 and CDC42 activate PAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35910", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17135", "l": "ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase] => ATP + L-seryl-[tyrosine-3-monooxygenase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37484", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine => 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936963", "l": "IRAK2 induces TRAF6 oligomerization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49399", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20851", "l": "H(+) + O2 + phosphate + pyruvate <=> acetyl phosphate + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26206", "l": "4-nitrophenol + H(+) + NADPH + O2 => 4-nitrocatechol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805276", "l": "CDK5 phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27632", "l": "glycolaldehyde + H(+) + NADH => ethylene glycol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034814", "l": "NTRK3 phosphorylates PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20338", "l": "(R)-2-O-sulfolactate + H2O => (R)-lactate + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44179", "l": "a 2,3-diacyl-sn-glycerol + H2O <=> 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012208", "l": "miR-26A and B bind to the 3'UTR of the KPNA2 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72672", "l": "The 60S subunit joins the translation initiation complex  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948757", "l": "AKT phosphorylates MKRN1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371554", "l": "HSF1 acetylation at Lys80 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11043", "l": "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate <=> 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047836", "l": "D-tryptophan N-malonyltransferase activity", "d": ["Catalysis of the reaction: D-tryptophan + malonyl-CoA = N(2)-malonyl-D-tryptophan + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164510", "l": "Conformational change in gp120 of Env oligomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.141", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22912", "l": "L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine", "d": []}, {"i": "EC:2.6.1.66", "l": "\"valine--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30578", "l": "3 menaquinone-8 + protoporphyrinogen IX <=> 3 menaquinol-8 + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34640", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 => H2O + NADP(+) + neopentalenolactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209109", "l": "E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879910", "l": "JAK2 is phosphorylated, activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34876", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) => 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25231", "l": "H(+) + L-arabinose + NADPH => L-arabinitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322427", "l": "Beta-catenin recruits CBP/p300 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55278", "l": "9-cis-retinyl tetradecanoate + CoA => 9-cis-retinol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10277", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) => 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034852", "l": "4,4-dimethyl-3-oxopentanal dehydrogenase activity", "d": ["Catalysis of the reaction: 4,4-dimethyl-3-oxopentanal + H2O = 4,4-dimethyl-3-oxopentanoate + 3 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32035", "l": "(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O = (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+)", "d": []}, {"i": "EC:3.7.1.17", "l": "\"4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004491", "l": "methylmalonate-semialdehyde dehydrogenase (acylating) activity", "d": ["Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391941", "l": "BLT receptors can bind LTB4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849906", "l": "SALM1 binds NMDA receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63829", "l": "L-alanine + vanillin => pyruvate + vanillylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67362", "l": "2 L-threonine => H2O + L-threonyl-L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10463", "l": "prostaglandin A1 <=> prostaglandin C1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61664", "l": "(2E,6E,10E)-geranylgeraniol + ATP = (2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66746", "l": "ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate => ATP + H2O + N-acetyl-L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29689", "l": "alpha-D-glucose 1-phosphate + alpha-maltohexaose => alpha-maltoheptaose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.154", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48265", "l": "H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] => H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74639", "l": "AMP(out) + CMP-N-acetyl-beta-neuraminate(in) = AMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709360", "l": "H2O2 reduces MetHb (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53535", "l": "(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate <=> (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72487", "l": "citrate(out) + phosphoenolpyruvate(in) = citrate(in) + phosphoenolpyruvate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.14", "l": "\"(Kdo)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0048019", "l": "receptor antagonist activity", "d": ["The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827993", "l": "Expression of PDPN in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47938", "l": "4-hydroxybenzoate + 2 H(+) + NADPH => 4-hydroxybenzaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199839", "l": "AKT can phosphorylate RSK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061769", "l": "ribosylnicotinate kinase activity", "d": ["Catalysis of the reaction: N-ribosylnicotinate + ATP = ADP + 2 H+ + nicotinate mononucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20706", "l": "an N-acetyl-D-amino acid + CoA + H(+) => a D-alpha-amino acid + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799246", "l": "CHEK1 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63208", "l": "5-amino-6-(D-ribitylamino)uracil + glyoxal = 5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67416", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55378", "l": "2 a quinone + 2 H2O => 2 a quinol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194800", "l": "botE LC cleaves target cell SNAP25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60420", "l": "H2O + triglucosyl-enterobactin = [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9612501", "l": "SGK phosphorylates CREB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13323", "l": "3-methyl-2-oxobutanoate + CO2 + NADH => (R)-3,3-dimethylmalate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9737780", "l": "MTTP binds lomitapide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30287", "l": "15-cis-phytoene + 2 a plastoquinone = 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25138", "l": "phosphate + pyridoxamine <=> H2O + pyridoxamine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043825", "l": "succinylornithine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + N(2)-succinyl-L-ornithine = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11078", "l": "catechol + CO2 + NAD(+) + NH4(+) => anthranilate + 3 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36160", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin] => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0097243", "l": "flavonoid binding", "d": ["Binding to a flavonoid, a compound containing two or more aromatic rings, each bearing at least one aromatic hydroxyl and connected with a carbon bridge."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63396", "l": "A + Fe(II)-heme i + H2O = AH2 + Fe(II)-hydroxyheme i", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41767", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E)) <=> CMP + ganglioside GT3 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22465", "l": "L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0047952", "l": "glycerol-3-phosphate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42551", "l": "uridine(746) in 23S rRNA <=> pseudouridine(746) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44125", "l": "hexadecanoyl-CoA + tetradecan-1-ol => CoA + tetradecanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17168", "l": "alpha-D-galactose 1-phosphate + dTTP + H(+) <=> diphosphate + dTDP-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696670", "l": "CHD1L is recruited to GG-NER site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848338", "l": "PNPLA4 hydrolyzes TAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0016781", "l": "phosphotransferase activity, paired acceptors", "d": ["Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43563", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70797", "l": "H(+)(out) + L-lysine(in) => H(+)(in) + L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20136", "l": "3-(indol-3-yl)lactate + NAD(+) <=> H(+) + indole-3-pyruvate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18658", "l": "(R)-glycerate + NADP(+) => 3-hydroxypyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71068", "l": "L-arginine(in) + L-phenylalanine(out) => L-arginine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559468", "l": "TLR1/2 ligand binds to CD14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68514", "l": "alpha-acoradiene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030352", "l": "inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16274", "l": "an N-acylsphing-4-enine + CDP-choline => a sphingomyelin + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73629", "l": "CTP(in) + GMP(out) => CTP(out) + GMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21332", "l": "acetyl-CoA + D-glucosamine = CoA + H(+) + N-acetyl-D-glucosamine", "d": []}, {"i": "EC:2.3.1.3", "l": "\"glucosamine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15385", "l": "L-asparagine = 3-cyano-L-alanine + H2O", "d": []}, {"i": "EC:4.2.1.65", "l": "\"3-cyanoalanine hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56770", "l": "2 A + all-trans-adonixanthin + 3 H2O => 2 AH2 + all-trans-zeaxanthin + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71303", "l": "RPE dimers isomerise RU5P to XY5P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13467", "l": "CoA + N(3)-oxalyl-L-2,3-diaminopropanoate => (S)-2,3-diaminopropanoate + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32053", "l": "adenosine 5'-tetraphosphate + AMP + 2 H(+) => H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10208", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)", "d": []}, {"i": "EC:2.3.2.8", "l": "\"arginyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.11", "l": "\"glutamate carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21678", "l": "(R)-lavandulyl diphosphate + diphosphate => 2 dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33899", "l": "FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose = FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose", "d": []}, {"i": "EC:1.1.98.3", "l": "\"decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46927", "l": "(R)-2-hydroxy-4-methylpentanoyl-CoA <=> 4-methylpent-2-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.128", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004313", "l": "[acyl-carrier-protein] S-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63633", "l": "a long-chain fatty acyl-AMP + holo-[ACP] => a long-chain fatty acyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14860", "l": "(indol-3-yl)acetate + ATP + L-lysine <=> ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848930", "l": "PTK6 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050599", "l": "deacetoxycephalosporin-C synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + O2 + penicillin N = CO2 + deacetoxycephalosporin C + H2O + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31886", "l": "(S)-2,3-epoxysqualene <=> delta-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51344", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032558", "l": "adenyl deoxyribonucleotide binding", "d": ["Binding to an adenyl deoxyribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51459", "l": "H2O + N-(9Z-octadecenoyl)-L-isoleucine <=> (9Z)-octadecenoate + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.86", "l": "\"rhamnogalacturonan acetylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "61.68653737057361", "identifiers": [{"i": "GO:0043167", "l": "ion binding", "d": ["Binding to an ion, a charged atoms or groups of atoms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781814", "l": "USP19 deubiquitinates RNF123 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66857", "l": "(2E)-geranyl diphosphate + 3 isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38077", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9718360", "l": "GNRHR binds GNRHR peptide agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018798", "l": "RHOV binds GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27352", "l": "arsenate + mycothiol <=> arseno-mycothiol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48105", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45773", "l": "[(1->4)-beta-D-mannosyl](n) + phosphate => [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20414", "l": "glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine => glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72991", "l": "2 Na(+)(out) + scyllo-inositol(out) = 2 Na(+)(in) + scyllo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679775", "l": "COMT binds COMT Inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1470009", "l": "Phosphorylation of STATs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11433", "l": "S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside => 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27483", "l": "acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47942", "l": "ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine => ganglioside GM2 (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.863640214551324", "identifiers": [{"i": "GO:0008318", "l": "protein prenyltransferase activity", "d": ["Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34503", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-epi-alpha-bisabolol + diphosphate", "d": []}, {"i": "EC:4.2.3.138", "l": "\"(+)-epi-alpha-bisabolol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25751", "l": "N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034026", "l": "L-amino-acid alpha-ligase activity", "d": ["Catalysis of the reaction: ATP + an L-amino acid + an L-amino acid = ADP + phosphate + L-aminoacyl-L-amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62608", "l": "glutathione + H(+) + hydrogen sulfide + ubiquinone-10 = S-sulfanylglutathione + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482770", "l": "Release of platelet secretory granule components (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68022", "l": "(2E)-geraniol + phosphate => (2E)-geranyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17712", "l": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate <=> 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44502", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534388", "l": "Progesterone Activation Of CatSper (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685605", "l": "SLAMF7 binds SLAMF7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371467", "l": "SIRT1 deacetylates HSF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22080", "l": "H(+) + NADH + O2 + quinolin-2-ol = H2O + NAD(+) + quinoline-2,8-diol", "d": []}, {"i": "EC:1.14.13.61", "l": "\"2-hydroxyquinoline 8-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55472", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.68", "l": "\"syn-pimaradiene 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68717", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + germacrene D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362416", "l": "Frataxin binds iron (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601976", "l": "Defective CYP21A2 does not 21-hydroxylate PROG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374173", "l": "AGT(34-41) binds to AGTR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22765", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799466", "l": "TP53I3 dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647994", "l": "RAS proteins are depalmitoylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651828", "l": "PARG dePARylates PARP1,PARP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102513", "l": "delphinidin 3-O-glucoside 5-O-glucosyltransferase (vanilloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> delphinidin 3,7-di O-beta-D-glucoside + vanillate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086410", "l": "CDK1 phosphorylates BORA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49547", "l": "(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O <=> 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16308", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O <=> 3-hydroxy-3-methylglutarate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114254", "l": "CYCS binds to APAF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63294", "l": "H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine => N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44538", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72464", "l": "L-threonyl-[protein] + NAD(+) => H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801762", "l": "REG3A oligomerize to form a pore complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793947", "l": "Defective MOGS does not cleave glucose from an N-glycosylated protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32386", "l": "(1S,2S,4R)-limonene-1,2-diol + NAD(+) <=> (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804996", "l": "p14ARF sequesters MDM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62498", "l": "diphosphate + L-arginyl-AMP => ATP + H(+) + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2545196", "l": "FN1 dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67215", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + O2 <=> (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264622", "l": "Cho is acetylated to AcCho by CHAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37999", "l": "2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine = H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11540", "l": "an N-acyl-D-mannosamine + NAD(+) = an N-acyl-D-mannosaminolactone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.233", "l": "\"N-acylmannosamine 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12611", "l": "6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine => mercaptopurine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043888", "l": "(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity", "d": ["Catalysis of the transfer of a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432148", "l": "Fgr may phosphorylate p38 MAPK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72634", "l": "Ca(2+)(in) + 3 Li(+)(out) <=> Ca(2+)(out) + 3 Li(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60039", "l": "H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate <=> 3-hydroxy-3-methylhexanoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24692", "l": "(E)-coniferyl acetate + NADPH => acetate + eugenol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451942", "l": "Within the IL-2R complex JAK3 phosphorylates JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047740", "l": "cephalosporin-C transaminase activity", "d": ["Catalysis of the reaction: (7R)-7-(5-carboxylato-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982775", "l": "Growth hormone receptor dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73207", "l": "sulfate(out) + sulfite(in) = sulfate(in) + sulfite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33256", "l": "2-demethylmenaquinol-7 + S-adenosyl-L-methionine => H(+) + menaquinol-7 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32186", "l": "cholesterol + O2 <=> cholest-5-en-3-one + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004070", "l": "aspartate carbamoyltransferase activity", "d": ["Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22777", "l": "2 H(+) + H2O2 + 2 Mn(2+) => 2 H2O + 2 Mn(3+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683925", "l": "ULK1 is dephosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202328", "l": "Translocation of PKC theta to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22795", "l": "isonocardicin A <=> nocardicin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63483", "l": "NADP(+) + prostaglandin F2alpha <=> 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61348", "l": "ATP + estrone 3-sulfate(in) + H2O = ADP + estrone 3-sulfate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67697", "l": "H2O + hexadecanedioyl-CoA => CoA + H(+) + hexadecanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051509", "l": "tomatidine UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + tomatidine = UDP + O-glucosyl-tomatidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68402", "l": "diphosphate + gamma-gurjunene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49668", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate = deoxyviolaceinate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195251", "l": "Assembly of the destruction complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.688704758796746", "identifiers": [{"i": "GO:0090482", "l": "vitamin transmembrane transporter activity", "d": ["Enables the transfer of a vitamin from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399711", "l": "Activation of Ca impermeable AMPA receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114354", "l": "SMAC binds XIAP:Caspase-7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26340", "l": "L-homocysteine + S-methyl-L-methionine <=> H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-919404", "l": "Phosphorylated STAT5 is released (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18036", "l": "benzoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45315", "l": "NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4411373", "l": "NLK translocates to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665410", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.66", "l": "\"thermitase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70093", "l": "hydroxyclavatol ethyl ether => ethanol + o-quinone methide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64798", "l": "(S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+) => H2O + L-lysine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22380", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol", "d": []}, {"i": "EC:3.1.1.11", "l": "\"pectinesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186778", "l": "SHP2 binds to the active receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0016418", "l": "S-acetyltransferase activity", "d": ["Catalysis of the transfer of an acetyl group to a sulfur atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15272", "l": "L-xylo-hex-3-ulonolactone <=> H(+) + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1467466", "l": "ABCA4 mediates atRAL transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24370", "l": "L-proline + NH4(+) => L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67844", "l": "a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68914", "l": "DNA polymerase alpha:primase binds at the origin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67836", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31233", "l": "4-acetamidobutanoate + 2 H(+) + NADH => 4-acetamidobutanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69248", "l": "H2O + sinigrin = (Z)-N-(sulfonatooxy)prop-2-enimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674095", "l": "PDGFRs bind type II TKI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43310", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674093", "l": "PDGFRs bind type I TKI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49121", "l": "H(+) + NADPH + O2 + protoviolaceinate => H2O + NADP(+) + violaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699007", "l": "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63003", "l": "(11Z,14Z,17Z)-eicosatrienamide + H2O <=> (11Z,14Z,17Z)-eicosatrienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032502", "l": "Activated NTRK2 binds FYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216061", "l": "SPP1 (osteopontin) binds integrin alpha8beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37388", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12883", "l": "2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+) => ADP-alpha-D-glucose + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693061", "l": "STAMBP binds STAM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37373", "l": "a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449077", "l": "Interleukin-16 is secreted (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683925", "l": "ULK1 is dephosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25896", "l": "H(+) + malonate = acetate + CO2", "d": []}, {"i": "EC:4.1.1.88", "l": "\"biotin-independent malonate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198314", "l": "DAG stimulates protein kinase C-delta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061658", "l": "URM1 conjugating enzyme activity", "d": ["Isoenergetic transfer of URM1 from one protein to another via the reaction X-URM1 + Y = Y-URM1 + X, where both the X-URM1 and Y-URM1 linkages are thioester bonds between the C-terminal amino acid of URM1 and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8862300", "l": "LYZ binds bacterial peptidoglycan (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696822", "l": "AKR1B15 reduces EST17b to E1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64405", "l": "carnosine(out) + H(+)(out) => carnosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40132", "l": "(9Z)-hexadecenoyl-CoA + H2O => (9Z)-hexadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72859", "l": "3',3',3'-c-tri-AMP + H2O = A[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749197", "l": "ORC1 binds to H4K20me2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33276", "l": "a 1,2-diacyl-sn-glycerol + H2O => a 2-acylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18294", "l": "ATP + CoA + oxalate => AMP + diphosphate + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029270", "l": "Recruitment of PLCgamma to membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.53", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38064", "l": "2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA => 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10958", "l": "H2O + NADP(+) + trans-2-coumarate => (E)-cinnamate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160931", "l": "Disassembly of tight junctions (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55837", "l": "calcitriol + UDP-alpha-D-glucuronate => calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67577", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O => [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.15", "l": "\"desampylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24956", "l": "H2O + N-acetyl-beta-D-muramate 6-phosphate = (R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52892", "l": "H2O + NADP(+) + nitrosobenzene = H(+) + NADPH + nitrobenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050314", "l": "sym-norspermidine synthase activity", "d": ["Catalysis of the reaction: 1,3-diaminopropane + S-adenosylmethioninamine = S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691167", "l": "CUL1, SKP1, FBXL5 bind (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15173", "l": "H(+) + H2O2 + NADPH = 2 H2O + NADP(+)", "d": []}, {"i": "EC:1.11.1.2", "l": "\"NADPH peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40111", "l": "butanoyl-CoA + H2O = butanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928627", "l": "EPHB phosphorylates TIAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56204", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] = 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029451", "l": "Activation of RAC1 by VAV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24008", "l": "ATP + hypotaurocyamine = ADP + H(+) + N(omega)-phosphohypotaurocyamine", "d": []}, {"i": "EC:2.7.3.6", "l": "\"hypotaurocyamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49809", "l": "a quinone + butan-1-ol => a quinol + butanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48671", "l": "20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373887", "l": "lactate + H+ [extracellular] <=> lactate + H+ [cytosol] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32415", "l": "(1S,2S,4R)-isodihydrocarveol + NAD(+) = (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54654", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => peregrinol diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912364", "l": "MIR181C microRNA binds 3'UTR of NOTCH4 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857686", "l": "FITM1, FITM2 bind TAGs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617182", "l": "PRKACA phosphorylates PLN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602466", "l": "Activation of MT-MMPs by FURIN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953398", "l": "PIR oxygenates quercetin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788628", "l": "p-Y-STATs dissociate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951443", "l": "Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004837", "l": "tyrosine decarboxylase activity", "d": ["Catalysis of the reaction: L-tyrosine = tyramine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982617", "l": "CYGB:O2 dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31619", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate", "d": []}, {"i": "EC:2.6.1.90", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9656891", "l": "OPN1SW binds 11cRAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661432", "l": "BIL binds ALB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3209165", "l": "ID1 sequesters ETS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58359", "l": "2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + L-arginyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59137", "l": "ATP + citrate + D-ornithine => AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45167", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9680443", "l": "ROCK1,2 bind ROCKi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19294", "l": "a monoacylglycerol + ATP => ADP + H(+) + monoacyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210289", "l": "Recruitment of SYK to p-DAP12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61479", "l": "a sphingoid base + octadecanoyl-CoA <=> an N-octadecanoyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391871", "l": "Autophosphorylation of NCAM1 bound Fyn (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15040", "l": "putrescine + S-adenosyl-L-methionine <=> H(+) + N-methylputrescine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982017", "l": "Active G alpha (q) binds RGS proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009010", "l": "sorbitol-6-phosphate 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015401", "l": "urea:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urea(out) + Na+(out) = urea(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421831", "l": "trans-Golgi Network Coat Assembly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6795473", "l": "PDPK1 phosphorylates SGK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43740", "l": "ATP + CoA + hexanoate = AMP + diphosphate + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847537", "l": "RAB43:GTP binds USP8NL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160931", "l": "Disassembly of tight junctions (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18397", "l": "ATP + L-glutamate + tRNA(Glx) = AMP + diphosphate + L-glutamyl-tRNA(Glx)", "d": []}, {"i": "EC:6.1.1.24", "l": "\"glutamate--tRNA(Gln) ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445091", "l": "Phosphorylation of Neurofascin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982778", "l": "Growth hormone binds the growth hormone receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35154", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) <=> (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64647", "l": "butan-1-ol + propanoyl-CoA <=> butyl propanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24990", "l": "calcitroate + H2O + 2 oxidized [adrenodoxin] => (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28532", "l": "phosphate + xanthosine => H2O + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446322", "l": "PARVA associates with Paxillin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9754129", "l": "CDK6 inhibitors bind CDK6 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70874", "l": "L-glutamine(in) + L-valine(out) + Na(+)(out) <=> L-glutamine(out) + L-valine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.2.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.14", "l": "\"chitinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632182", "l": "PRMT1 methylates ESRs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950581", "l": "Expression of Cofilin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.142364941642427", "identifiers": [{"i": "GO:0042626", "l": "ATPase-coupled transmembrane transporter activity", "d": ["Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60788", "l": "gibberellin A24 + H(+) + O2 = CO2 + gibberellin A9 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.153", "l": "\"adenosine tuberculosinyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74484", "l": "(Z)-dehydrocyclopeptine + 2-oxoglutarate + O2 => (-)-cyclopenine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43971", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36603", "l": "2-oxoglutarate + L-enduracididine + O2 = (3S)-3-hydroxy-L-enduracididine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.40", "l": "\"enduracididine beta-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74506", "l": "H(+) + NADPH + yaequinolone D <=> H2O + NADP(+) + penigequinolone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33984", "l": "(+)-copalyl diphosphate => diphosphate + miltiradiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48797", "l": "O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73462", "l": "5 H(+) + 2 O2 + protochlorophyllide a + 4 reduced [2Fe-2S]-[ferredoxin] <=> 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56849", "l": "1,6-didemethyltoxoflavin + S-adenosyl-L-methionine => H(+) + reumycin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20723", "l": "H2O + isopenicillin N + phenylacetyl-CoA <=> CoA + H(+) + L-2-aminoadipate + penicillin G", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45071", "l": "(R)-carnitine + an acyl-CoA <=> CoA + O-acyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608862", "l": "SCRIB is required for asymmetric membrane localization of VANGL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381612", "l": "GLP1R binds GLP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22410", "l": "(2E)-geranyl diphosphate + diphosphate => dimethylallyl diphosphate + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71290", "l": "chloride(out) + L-arginine(out) + 2 Na(+)(out) <=> chloride(in) + L-arginine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.535054500181104", "identifiers": [{"i": "GO:0046992", "l": "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y."]}, {"i": "EC:1.21.-.-", "l": "\"Catalyzing the reaction X-H + Y-H = 'X-Y'\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847968", "l": "PTEN binds FRK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18687", "l": "2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+) => H(+) + NADPH + O2 + pentachlorophenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17283", "l": "H2O + L-ectoine => (2S)-4-acetamido-2-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47188", "l": "Co(I)-[methylated-thiol-specific corrinoid protein] + methanethiol = hydrogen sulfide + methyl-Co(III)-[methylated-thiol-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043956", "l": "3-hydroxypropionyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: 3-hydroxypropionyl-CoA = acryloyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25019", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109639", "l": "Formation of the closed pre-initiation complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17472", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052844", "l": "inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12479", "l": "H2O + N-formyl-L-glutamate <=> formate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43079", "l": "erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57869", "l": "(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 => (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36703", "l": "(2S,5S)-5-carboxymethylproline + ATP = (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.3.6", "l": "\"carbapenam-3-carboxylate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19129", "l": "ATP + thymidine = ADP + dTMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52427", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955893", "l": "SOCS4 gene expression is inhibited by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.722653756574275", "identifiers": [{"i": "GO:0140375", "l": "immune receptor activity", "d": ["Receiving a signal and transmitting it in a cell to initiate an immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.96", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70789", "l": "H(+)(out) + L-citrulline(out) + L-ornithine(in) => H(+)(in) + L-citrulline(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61169", "l": "quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46429", "l": "4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18410", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374896", "l": "Uptake of Noradrenaline (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15566", "l": "an N-acyl-L-amino acid + H2O => a carboxylate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57283", "l": "a guanosine in RNA + glyoxal <=> an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46029", "l": "H2O2 + tetradecanoate => (2R)-hydroxytetradecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050147", "l": "nucleoside ribosyltransferase activity", "d": ["Catalysis of the reaction: D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41253", "l": "7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55602", "l": "a mannosylinositol-1-phosphoceramide + GDP + H(+) => an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38977", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668398", "l": "CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681596", "l": "3CLp dimer binds α-Ketoamides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67743", "l": "N-acetyl-beta-neuraminate <=> aceneuramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58766", "l": "1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183051", "l": "CBL ubiquitinates Sprouty (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877192", "l": "RUNX1 binds FOXP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33050", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] <=> (+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869683", "l": "oxPL binds LBP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5432825", "l": "HMGB1 binds TLR4:LY96 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451309", "l": "Edited Kainate Receptor binds glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858500", "l": "CLEC10A binds Tn-MUC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336182", "l": "GPR37 binds prosaptide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43820", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60901", "l": "a cytidine in RNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686790", "l": "ER-alpha glucosidases bind ER-alpha glucosidase inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24302", "l": "2 cob(II)yrinate a,c diamide + FMNH2 => 2 cob(I)yrinate a,c diamide + FMN + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391936", "l": "EP1 receptor can bind PGE2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106363", "l": "protein-cysteine methyltransferase activity", "d": ["Catalysis of the reaction: L-cysteinyl-[protein] + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]."]}, {"i": "RHEA:66544", "l": "L-cysteinyl-[protein] + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68325", "l": "1D-myo-inositol 2,5-bisphosphate + H2O => 1D-myo-inositol 2-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36679", "l": "dTDP-6-deoxy-alpha-D-allose + NAD(+) = dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031718", "l": "type 1 cannabinoid receptor binding", "d": ["Binding to a type 1 cannabinoid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726580", "l": "PGR binds PGR agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9670114", "l": "Histone H3.3 deposition at telomere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977626", "l": "C4b-binding protein binds C4b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66921", "l": "6-deoxy-6-sulfo-D-fructose + D-erythrose 4-phosphate => (2S)-3-sulfolactaldehyde + D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20350", "l": "H(+) + NADH + O2 + toluene => 2-hydroxytoluene + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.093101469280398", "identifiers": [{"i": "GO:0019207", "l": "kinase regulator activity", "d": ["Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36810", "l": "H(+) + malonyl-CoA + octacosanoyl-CoA <=> 3-oxo-triacontanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30758", "l": "ATP + carbamate <=> ADP + carbamoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74637", "l": "5-dehydro-6-demethoxy-6-hydroxyfumagillol + CO2 + succinate => 2-oxoglutarate + 5-dehydro-6-demethoxyfumagillol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34119", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA = 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA", "d": []}, {"i": "EC:2.3.1.206", "l": "\"3,5,7-trioxododecanoyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706312", "l": "Active FLT3 binds to LCK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18692", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50151", "l": "a fatty acid ethyl ester + H2O <=> a fatty acid + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016151", "l": "nickel cation binding", "d": ["Binding to a nickel (Ni) cation."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102827", "l": "galactosylononitol-raffinose galactosyltransferase activity", "d": ["Catalysis of the reaction: raffinose + D-galactosylononitol = stachyose + 1D-4-O-methyl-myo-inositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1222491", "l": "Lactoferrin scavenges iron ions (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692437", "l": "ANG binds F-actin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661230", "l": "MT1A binds arsenic (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16650", "l": "(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9676257", "l": "Formation of the SET1A complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19876", "l": "dehydroepiandrosterone 3-sulfate + H2O <=> 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809764", "l": "SBF1 binds MTMR2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19802", "l": "(R)-4'-phosphopantetheine + ATP + H(+) => 3'-dephospho-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987039", "l": "JAK1 binds IL20RA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25298", "l": "acetaldehyde + H2O + NADP(+) = acetate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33542", "l": "ergosteryl ester + H2O <=> a carboxylate + ergosterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47476", "l": "(3E)-tetradecenoyl-CoA = (2E)-tetradecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66392", "l": "ATP + H2O + prostaglandin E1(in) = ADP + H(+) + phosphate + prostaglandin E1(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106317", "l": "methane monooxygenase NADH activity", "d": ["Catalysis of the reaction: methane + NADH + H+ + O2 = methanol + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74994", "l": "Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158313", "l": "factor XII -> factor XIIa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65430", "l": "deamido-NAD(+)(out) + NAD(+)(in) => deamido-NAD(+)(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.57", "l": "\"fructuronate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635842", "l": "ULK3 phosphorylates GLI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.17", "l": "\"3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2400001", "l": "AKT1 E17K mutant phosphorylates CHUK (IKKalpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768925", "l": "MDM2 gene expression is repressed by NPAS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44515", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43592", "l": "all-trans-zeaxanthin + O2 = (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021888", "l": "MECP2 binds CREB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29368", "l": "CMP + H2O => cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15695", "l": "(R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O => (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794444", "l": "ALB binds Cipro (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244506", "l": "botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74225", "l": "L-serine + tRNA(Ala) => H2O + L-seryl-tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033981", "l": "D-dopachrome decarboxylase activity", "d": ["Catalysis of the reaction: D-dopachrome + H+ = 5,6-dihydroxyindole + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63314", "l": "15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46696", "l": "a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.165", "l": "\"methyl halide transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70238", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol <=> an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031817", "l": "P2Y8 nucleotide receptor binding", "d": ["Binding to a P2Y8 nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047285", "l": "flavonol-3-O-glycoside xylosyltransferase activity", "d": ["Catalysis of the reaction: flavonol 3-O-glycoside + UDP-D-xylose = flavonol 3-O-D-xylosylglycoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866269", "l": "ARRB bind GPCRs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12001", "l": "formate + NADP(+) => CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177479", "l": "Axonal transport of NGF:Trk complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52930", "l": "2 GMP + 2 H(+) => 3',3'-c-di-GMP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16735", "l": "CO2 + orcinol => H(+) + orsellinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50696", "l": "calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23320", "l": "D-tryptophan + malonyl-CoA = CoA + H(+) + N(2)-malonyl-D-tryptophan", "d": []}, {"i": "EC:2.3.1.112", "l": "\"D-tryptophan N-malonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805126", "l": "AURKB phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62004", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45532", "l": "H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088134", "l": "PLK1 phosphorylates FOXM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49250", "l": "galactitol 1-phosphate(in) + L-histidyl-[protein] => galactitol(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27555", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + 2 diphosphate", "d": []}, {"i": "EC:2.5.1.82", "l": "\"hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46150", "l": "a 2'-deoxyribonucleoside + H(+) + triphosphate => a 2'-deoxyribonucleoside 5'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29651", "l": "agmatine(in) + L-arginine(out) = agmatine(out) + L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39624", "l": "3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034941", "l": "pyrrole-2-carboxylate decarboxylase activity", "d": ["Catalysis of the reaction: pryrole-2-carboxylate + H+ = pyrrole + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209278", "l": "Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821366", "l": "AKAP8L binds MLL2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62753", "l": "H2O + pravastatin lactone => (S)-2-methylbutanoate + H(+) + pravastatin diol lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31848", "l": "(S)-2,3-epoxysqualene => shionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59121", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+) => 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62211", "l": "3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33760", "l": "a 3-oxo-fatty acyl-CoA + H(+) + NADPH => a 3-hydroxy-fatty acyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67699", "l": "H2O + hexadecanedioyl-CoA <=> CoA + H(+) + hexadecanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46206", "l": "androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43824", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43605", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71801", "l": "Ca(2+)(out) + H(+)(in) => Ca(2+)(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49671", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate <=> deoxyviolaceinate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944214", "l": "Association of procollagen type I (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140612", "l": "DNA damage sensor activity", "d": ["A molecule that recognises toxic DNA structures, for example, double-strand breaks or collapsed replication forks, and initiates a signalling response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52132", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O = a 5'-end 5'-monophospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193650", "l": "p75NTR binds to NADE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64738", "l": "(E)-4-hydroxynon-2-enal + H(+) + NADPH => 4-hydroxynonanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13830", "l": "GDP-alpha-D-rhamnose + NADP(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.4", "l": "\"xanthine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67467", "l": "H2O + propanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690461", "l": "FKBP1A binds tacrolimus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34830", "l": "H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2 <=> H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48533", "l": "ganglioside GQ1c (d18:1(4E)) + H2O => ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63843", "l": "[thioredoxin]-dithiol + tert-butyl hydroperoxide <=> [thioredoxin]-disulfide + H2O + tert-butanol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018683", "l": "camphor 5-monooxygenase activity", "d": ["Catalysis of the reaction: (+)-camphor + putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11847", "l": "acetyl-CoA + formate <=> CoA + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65247", "l": "(2S)-hesperetin + UDP-alpha-D-glucose <=> (2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66374", "l": "glycerol + phosphate => H2O + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.98.1.-", "l": "\"Forming coordination complexes\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647978", "l": "pro-RAS proteins are farnesylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27466", "l": "ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) => ADP-D-glycero-beta-D-manno-heptose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69560", "l": "D-mannose(out) + H(+)(out) = D-mannose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44596", "l": "a fatty acyl-[ACP] + H2O = a fatty acid + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549493", "l": "Expression of PERIOD-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41594", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928600", "l": "N-WASP binds ITSN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592250", "l": "NRF1, PPRC1:HCFC1:NRF2 bind the TFB1M promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53523", "l": "1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20716", "l": "H(+) + H2O + S-adenosyl-L-homocysteine = NH4(+) + S-inosyl-L-homocysteine", "d": []}, {"i": "EC:3.5.4.28", "l": "\"S-adenosylhomocysteine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.135", "l": "\"N(4)-acetylcytidine amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008267", "l": "ESR1 binds to TGFA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008459", "l": "chondroitin 6-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16908", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O <=> a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13412", "l": "7-aminomethyl-7-carbaguanine + 2 NADP(+) <=> 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33586", "l": "L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate <=> 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730841", "l": "Phosphorylation and activation of VAV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37408", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55778", "l": "all-trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoate + H(+) + UDP => all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051060", "l": "pullulanase activity", "d": ["Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in pullulan (a linear polymer of alpha-(1,6)-linked maltotriose units) and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14334", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol => 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69519", "l": "N-acetyl-D-galactosamine + O2 <=> H2O2 + N-acetyl-D-galactosamino-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55203", "l": "5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine <=> 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3134946", "l": "DDX41 ubiquitination by TRIM21 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64175", "l": "L-altrarate <=> galactarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63586", "l": "2-deoxyecdysone + phosphate => 2-deoxyecdysone 22-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202969", "l": "Caspase mediated cleavage of beta-catenin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050313", "l": "sulfur dioxygenase activity", "d": ["Catalysis of the reaction: sulfur + O2 + H2O = sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190265", "l": "FGFR4 binds to FGF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21627", "l": "FMNH2 + NADP(+) <=> FMN + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928607", "l": "p-EPHs bind VAV2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60979", "l": "(E)-4-hydroxynon-2-en-1-ol + NAD(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9674529", "l": "AAMP binds to TBXA2R (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25785", "l": "2-dehydro-3-deoxy-L-rhamnonate => (S)-lactaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9609310", "l": "β-blockers bind ADRB1,2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22100", "l": "3,5-dibromo-4-hydroxybenzonitrile + 2 H2O = 3,5-dibromo-4-hydroxybenzoate + NH4(+)", "d": []}, {"i": "EC:3.5.5.6", "l": "\"bromoxynil nitrilase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36432", "l": "a purine 2'-deoxy-D-ribonucleoside + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018590", "l": "methylsilanetriol hydroxylase activity", "d": ["Catalysis of the reaction: methylsilanetriol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylsilanetriol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22133", "l": "ATP + D-maltose(out) + H2O => ADP + D-maltose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17066", "l": "(R)-mevalonate + ATP => (R)-5-phosphomevalonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9005980", "l": "IL21 binds IL21R:JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-500708", "l": "GRIK3 homomer binds glutamate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62919", "l": "an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine <=> an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19130", "l": "ATP + thymidine => ADP + dTMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33017", "l": "[(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+) => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050094", "l": "methionine-glyoxylate transaminase activity", "d": ["Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047679", "l": "arginine racemase activity", "d": ["Catalysis of the reaction: L-arginine = D-arginine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77589", "l": "Recognition of AAUAAA sequence by CPSF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10021", "l": "H2O + L-saccharopine + NADP(+) => (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047324", "l": "phosphoenolpyruvate-glycerone phosphotransferase activity", "d": ["Catalysis of the reaction: glycerone + phosphoenolpyruvate = glycerone phosphate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69523", "l": "H2O + N-acetyl-D-galactosamino-1,5-lactone <=> H(+) + N-acetyl-D-galactosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69656", "l": "H2O + quercetin 3-O-beta-D-glucoside => beta-D-glucose + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-741411", "l": "CYLD deubiquitinates NEMO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416530", "l": "FFAR1:FFAR1 ligands activates Gq (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19696", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) <=> 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73602", "l": "CDP(in) + CTP(out) <=> CDP(out) + CTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73381", "l": "(R)-lipoate(in) + 2 Na(+)(in) => (R)-lipoate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21160", "l": "acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA", "d": []}, {"i": "EC:2.3.3.8", "l": "\"ATP citrate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29798", "l": "ATP(in) + H2O(in) + Zn(2+)(out) <=> ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944218", "l": "Association of procollagen type VIII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372529", "l": "Release of acetylcholine at the synapse (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9718360", "l": "GNRHR binds GNRHR peptide agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5631885", "l": "PRDX1 overoxidizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28883", "l": "H(+)(in) + L-threonine(in) = H(+)(out) + L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045174", "l": "glutathione dehydrogenase (ascorbate) activity", "d": ["Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015515", "l": "citrate:succinate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15311", "l": "biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin] => (2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165179", "l": "Formation of TSC1:TSC2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45275", "l": "12-phosphooxy-(9Z)-octadecenoate + H2O <=> 12-hydroxy-(9Z)-octadecenoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40981", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27977", "l": "6-carboxy-5,6,7,8-tetrahydropterin + H(+) <=> 7-carboxy-7-deazaguanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31052", "l": "(3R)-beta-leucine + H2O + NAD(+) => 4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.7", "l": "\"D-glutamate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022734", "l": "MECP2 binds FKBP5 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951695", "l": "TEADs:YAP1 binds CTGF gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73530", "l": "TDP(out) + UTP(in) <=> TDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60145", "l": "ATP + L-glutamate + L-glutamyl-[protein] => ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30359", "l": "chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 = chlorophyllide b + 3 H2O + 2 NADP(+)", "d": []}, {"i": "EC:1.14.13.122", "l": "\"chlorophyllide a oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.128", "l": "\"7-methylxanthine demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102444", "l": "isorhamnetin 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: isorhamnetin + S-adenosyl-L-methionine <=> 3,3'-dimethylquercetin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165195", "l": "GTP loading by Rheb (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65437", "l": "a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+) => a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53210", "l": "2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => daidzein + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51602", "l": "3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873929", "l": "Casein kinase II phosphorylates STARD10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004500", "l": "dopamine beta-monooxygenase activity", "d": ["Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27700", "l": "beta-L-galactose 1-phosphate + GDP + H(+) => GDP-beta-L-galactose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382061", "l": "Extracellular processing of novel PDGFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36547", "l": "octadecanoyl-CoA + sphinganine = CoA + H(+) + N-(octadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37401", "l": "1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023028", "l": "MHC class I protein binding, via lateral surface", "d": ["Binding to a major histocompatibility complex class I molecules via the lateral surface."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11163", "l": "2-oxoglutarate + L-2,4-diaminobutanoate <=> L-aspartate 4-semialdehyde + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417898", "l": "P2Y4 receptor can bind to UTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009940", "l": "amino-terminal vacuolar sorting propeptide binding", "d": ["Binding to an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin-coated vesicles."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52435", "l": "(R)-2,3-diaminopropanoate + H(+) + H2O <=> 2 NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48866", "l": "FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine => 2-methylpropan-1-amine + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56380", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 = (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O", "d": []}, {"i": "EC:1.14.19.56", "l": "\"1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] chlorinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678128", "l": "Spike glycoprotein of SARS coronavirus binds ACE2 on host cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983138", "l": "Transport of MHC heterotrimer to ER exit site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663264", "l": "RORA, EP300 bind CPT1A gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156910", "l": "Formation of eEF1B complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62871", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2 <=> H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16049", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266350", "l": "CETP-mediated lipid exchange: LDL gains cholesterol ester (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0019903", "l": "protein phosphatase binding", "d": ["Binding to a protein phosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36332", "l": "ATP + dimethylallyl diphosphate => diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010943", "l": "NADPH pyrophosphatase activity", "d": ["Catalysis of the reaction: NADPH + H2O = NMNH + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35086", "l": "diacetylchitobiose-6'-phosphate + H2O <=> acetate + N'-monoacetylchitobiose-6'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036424", "l": "L-phosphoserine phosphatase activity", "d": ["Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15905", "l": "3-hydroxycyclohexanone + A = AH2 + cyclohexane-1,3-dione", "d": []}, {"i": "EC:1.1.99.26", "l": "\"3-hydroxycyclohexanone dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17292", "l": "beta-D-fructose 2,6-bisphosphate + H2O <=> beta-D-fructose 6-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70394", "l": "3-oxosphinganine + eicosanoyl-CoA <=> CoA + H(+) + N-eicosanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9656893", "l": "OPN1MW binds 11cRAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37904", "l": "6-hydroxytryprostatin B + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + tryprostatin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18131", "l": "a 2-oxocarboxylate + 2 H(+) + NADPH => 2-oxoaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47756", "l": "guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49243", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) <=> L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848414", "l": "Activated PTK6 binds CDKN1B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32883", "l": "(11R)-dihydroartemisinic aldehyde + NADP(+) = (+)-artemisinic aldehyde + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.92", "l": "\"artemisinic aldehyde Delta(11(13)) reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003999", "l": "adenine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015355", "l": "secondary active monocarboxylate transmembrane transporter activity", "d": ["Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55735", "l": "19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421218", "l": "xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65688", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029273", "l": "PI3K binds to p-6Y-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16114", "l": "2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) => 2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993802", "l": "HLCS biotinylates PC:Mn2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27674", "l": "ATP + dADP = ADP + dATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65396", "l": "8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.39", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30778", "l": "H2O + O2 + pyridoxamine <=> H2O2 + NH4(+) + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22988", "l": "3-oxopropanoate + CoA + NADP(+) = acetyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44501", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008307", "l": "structural constituent of muscle", "d": ["The action of a molecule that contributes to the structural integrity of a muscle fiber."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50560", "l": "acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004805", "l": "trehalose-phosphatase activity", "d": ["Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.12", "l": "\"DNA helicase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.337", "l": "\"reticuline N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050150", "l": "o-pyrocatechuate decarboxylase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxybenzoate + H+ = catechol + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8963734", "l": "IL9 binds IL9R:JAK1 and IL2RG:JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73057", "l": "estrone 3-sulfate(in) + hydrogencarbonate(out) => estrone 3-sulfate(out) + hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47918", "l": "ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate => ATP + N-hexanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.13", "l": "\"retroviral ribonuclease H\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29000", "l": "H(+)(out) + homoserine lactone(in) => H(+)(in) + homoserine lactone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59848", "l": "(2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH = (S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549129", "l": "OCT1 transports organic cations into hepatic cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49552", "l": "H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] = H(+) + L-lysyl-[protein] + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042556", "l": "eukaryotic elongation factor-2 kinase regulator activity", "d": ["Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42821", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 => H2O + 2 NADP(+) + tetracenomycin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47512", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH = isocholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28949", "l": "H(+)(in) + L-arabinose(out) => H(+)(out) + L-arabinose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73120", "l": "kaempferol + S-adenosyl-L-methionine => H(+) + kaempferol 7-methyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928627", "l": "EPHB phosphorylates TIAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695841", "l": "FLT3 mutant dimers bind GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140629", "l": "small conductance calcium-activated potassium channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a small conductance calcium-activated potassium channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21814", "l": "7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665998", "l": "MKL1 binds SRF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65670", "l": "a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693347", "l": "CRYM reduces P2C to PPCA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49966", "l": "H2O2 + phenazine => 5,10-dihydrophenazine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28109", "l": "galactitol 1-phosphate + NAD(+) <=> H(+) + keto-D-tagatose 6-phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875568", "l": "RAPGEF1 activates RAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701485", "l": "Active ALK binds JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43465", "l": "H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "61.747746368481451", "identifiers": [{"i": "GO:0016709", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68886", "l": "3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+) => 3-hydroxybenzoate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57705", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) => 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13112", "l": "2-acetamidofluorene + H2O + NAD(+) <=> H(+) + N-hydroxy-2-acetamidofluorene + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938853", "l": "CDK6 binds RUNX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610036", "l": "Defective GALE does not epimerise UDP-Gal to UDP-Glc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174209", "l": "Phosphorylated Emi1 binds the beta-TrCP in the SCF complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30321", "l": "7-methylxanthine + formaldehyde + H2O + NAD(+) => H(+) + NADH + O2 + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005427", "l": "proton-dependent oligopeptide secondary active transmembrane transporter activity", "d": ["Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39255", "l": "(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41231", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72471", "l": "citrate(out) + D-threo-isocitrate(in) = citrate(in) + D-threo-isocitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27747", "l": "H(+) + L-cysteine => CO2 + cysteamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450551", "l": "AUF1 binds translation and heat shock proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71164", "l": "homogentisate + O2 => maleylacetoacetate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41455", "l": "5-methyl-1-naphthoate + H(+) + NADPH + O2 <=> 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626699", "l": "MARK4 binds ODF2 in the centriole (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50234", "l": "biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72148", "l": "AH2 + S-adenosyl-L-methionine + UTP => 3'-deoxy-3',4'-didehydro-UTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605591", "l": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22320", "l": "2 alpha-D-glucose 1-phosphate + H2O = D-maltose + 2 phosphate", "d": []}, {"i": "EC:2.4.1.139", "l": "\"maltose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390438", "l": "FAR2 reduces PalmCoA to HXOL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022849", "l": "glutamate-gated calcium ion channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44408", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39346", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA <=> (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37552", "l": "3-dehydro-D-glucose 6-phosphate + L-glutamate => 2-oxoglutarate + D-kanosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660663", "l": "Caspase-8 cleaves IL1B precursor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418850", "l": "Activation of Cdc42 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28381", "l": "ATP + N(6)-(D-fructosyl)-L-lysine <=> ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018457", "l": "perillyl-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + perillyl alcohol = H+ + NADH + perillyl aldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047211", "l": "alpha-1,4-glucan-protein synthase (ADP-forming) activity", "d": ["Catalysis of the reaction: ADP-D-glucose + protein = alpha-D-glucosyl-protein + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71794", "l": "(R)-lactate(in) + H(+)(in) <=> (R)-lactate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36237", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA => 1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114544", "l": "p115-RhoGEF activation of RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16006", "l": "galactarate => 5-dehydro-4-deoxy-D-glucarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39767", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-265456", "l": "NPC1L1 binds ezetimibe (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64508", "l": "acetyl-CoA + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine = 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + 4 CO2 + 5 CoA + H2O + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55857", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5612510", "l": "Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19769", "l": "phaseollidin hydrate = H2O + phaseollidin", "d": []}, {"i": "EC:4.2.1.97", "l": "\"phaseollidin hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37913", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28420", "l": "(R)-carnitinyl-CoA + 4-(trimethylamino)butanoate => (R)-carnitine + 4-(trimethylamino)butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29371", "l": "dAMP + H2O = 2'-deoxyadenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018582", "l": "1-hydroxy-2-naphthoate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 = (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29291", "l": "(25S)-3-oxocholest-4-en-26-oate + ATP + CoA = (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.42", "l": "\"3-oxocholest-4-en-26-oate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50052", "l": "ATP + H2O + taurocholate(in) = ADP + H(+) + phosphate + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60819", "l": "2-oxoglutarate + gibberellin A14 aldehyde + O2 <=> CO2 + gibberellin A14 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198508", "l": "MDH1 oxidizes MAL to OA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189439", "l": "ALAD condenses 2 dALAs to form PBG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295519", "l": "IL7R is phosphorylated on Y499 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21563", "l": "3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol <=> 1,4-dithiothreitol + 2,3-epoxyphylloquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68310", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68434", "l": "(3R)-hydroxy-beta-ionone + (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal => lutein + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25616", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> terpentedienyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60188", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate", "d": []}, {"i": "EC:1.14.11.65", "l": "\"[histone H3]-dimethyl-L-lysine(9) demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018798", "l": "RHOV binds GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18424", "l": "acetyl-CoA + chloramphenicol <=> chloramphenicol 3-acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39256", "l": "(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20712", "l": "6-carboxyhexanoyl-CoA + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55309", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56918", "l": "5alpha-androstan-3,17-dione + H(+) + NADPH => 3beta-hydroxy-5alpha-androstan-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62824", "l": "beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33311", "l": "2 A + hydroxylamine + NH4(+) = 2 AH2 + H(+) + H2O + N2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42086", "l": "9-cis-retinoate + 2 H(+) + NADH => 9-cis-retinal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902122", "l": "chenodeoxycholic acid binding", "d": ["Binding to chenodeoxycholic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21014", "l": "4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27462", "l": "D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) => diphosphate + GDP-D-glycero-alpha-D-manno-heptose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59804", "l": "L-phenylalanine = D-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951951", "l": "RUNX3 binds EP300 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49507", "l": "phosphinomethylmalate <=> phosphinomethylisomalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32854", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15300", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26483", "l": "adenosine(37) in tRNA + dimethylallyl diphosphate => diphosphate + N(6)-dimethylallyladenosine(37) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49430", "l": "CMP-5'-phosphonoformate + diphosphate => CTP + phosphonoformate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247840", "l": "WLS binds WNT ligands in the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5252072", "l": "AZGP1 binds PIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38015", "l": "delta-tocotrienol = 6-geranylgeranyl-2-methylbenzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034879", "l": "2,3,6-trihydroxyisonicotinate decarboxylase activity", "d": ["Catalysis of the reaction: 2,3,6-trihydroxyisonicotinate = 2,3,6-trihydroxypyridine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804402", "l": "TP53 binds POU4F1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46134", "l": "25-hydroxycholesterol + H2O + NADP(+) => cholesterol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72573", "l": "dehydroepiandrosterone 3-sulfate(out) + pentanoate(in) => dehydroepiandrosterone 3-sulfate(in) + pentanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5213464", "l": "RIPK1 is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672011", "l": "p-AMPK:AMP binds the ULK complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008773", "l": "[protein-PII] uridylyltransferase activity", "d": ["Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54899", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate + ATP + CoA <=> (10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212380", "l": "Formation of TRAP coactivator complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65080", "l": "asperaculane D + O2 + reduced [NADPH--hemoprotein reductase] = asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68085", "l": "GTP + L-histidyl-[RNA ligase] => diphosphate + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47769", "l": "guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72636", "l": "1-hydroxy-6-methoxyphenazine N(10)-oxide + S-adenosyl-L-methionine => 1,6-dimethoxyphenazine N(5)-oxide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9749197", "l": "ORC1 binds to H4K20me2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371518", "l": "SIRT1 binds to HSF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27419", "l": "6-hydroxynicotinate + 2 Fe(II)-[cytochrome] + 2 H(+) => 2 Fe(III)-[cytochrome] + H2O + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44662", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18469", "l": "an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.68", "l": "\"glutamine N-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434989", "l": "SEMA7A binds to PLXNC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63440", "l": "(2R)-3-phosphoglycerate + GTP + H(+) = 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate", "d": []}, {"i": "EC:2.7.7.106", "l": "\"3-phospho-D-glycerate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57287", "l": "a guanosine in RNA + methylglyoxal <=> an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009072", "l": "STAT3 phosphorylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56845", "l": "nocamycin E + S-adenosyl-L-methionine => nocamycin I + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66227", "l": "asc-C9-CoA + O2 <=> asc-DeltaC9-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955748", "l": "RUNX1 binds the SOCS3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102974", "l": "hydroxyversicolorone reductase activity", "d": ["Catalysis of the reaction: versicolorone + NADP = hydroxyversicolorone + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948703", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50064", "l": "ATP + H2O + taurochenodeoxycholate(in) = ADP + H(+) + phosphate + taurochenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59581", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester => CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46430", "l": "(25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin] => 4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40597", "l": "CoA + dodecanedioate + H(+) => dodecanedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32863", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605723", "l": "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936058", "l": "miR-675 binds RUNX1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016795", "l": "phosphoric triester hydrolase activity", "d": ["Catalysis of the hydrolysis of a phosphoric triester."]}, {"i": "EC:3.1.8.-", "l": "\"Phosphoric triester hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67748", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53111", "l": "2-hydroxyestrone + S-adenosyl-L-methionine <=> 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63565", "l": "apelin-13 + H2O => apelin-12 + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374664", "l": "Phosphorylation and activation of Ezrin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49018", "l": "2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one => aurachin C epoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0030284", "l": "nuclear estrogen receptor activity", "d": ["Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0061547", "l": "glycogen synthase activity, transferring glucose-1-phosphate", "d": ["Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939201", "l": "ESR dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174058", "l": "Degradation of multiubiquitinated Cdh1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106032", "l": "snRNA pseudouridine synthase activity", "d": ["Catalysis of the reaction: an snRNA uridine = an snRNA pseudouridine. Conversion of uridine in an snRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706308", "l": "Active FLT3 binds to GRB10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17008", "l": "ATP + D-glucuronate <=> 1-phospho-alpha-D-glucuronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51779", "l": "4-prenylphlorisobutanophenone + dimethylallyl diphosphate <=> deoxycohumulone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0043533", "l": "inositol 1,3,4,5 tetrakisphosphate binding", "d": ["Binding to inositol 1,3,4,5 tetrakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15510", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140442", "l": "peroxide sensor activity", "d": ["Binding to hydrogen peroxide (H2O2) and eliciting a change in the protein's activity in response to the intracellular level of that small molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74175", "l": "a secondary alkyl amine + H2O + NAD(+) = a ketone + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40260", "l": "(2E)-hexadecenedioyl-CoA + H2O => (3S)-hydroxyhexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41520", "l": "menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640167", "l": "RRAGA,B exchanges GDP for GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70959", "l": "D-tyrosine + H2O + O2 = 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940959", "l": "Neurolysin degrades neurotensin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392295", "l": "Gbeta:gamma recruits PI3K gamma (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60155", "l": "gamma-L-glutamyl-L-glutamyl-[protein] + H2O <=> L-glutamate + L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199112", "l": "CRTAM binds to NECL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31421", "l": "(-)-beta-curcumene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27874", "l": "isochorismate = pyruvate + salicylate", "d": []}, {"i": "EC:4.2.99.21", "l": "\"isochorismate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192830", "l": "Viral Polymerase Assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46171", "l": "ATP + CoA + pentanoate <=> AMP + diphosphate + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781922", "l": "USP13 binds UFD1L:SKP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.55", "l": "\"caldesmon-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30472", "l": "(2Z,6Z)-farnesyl diphosphate => (1S,5S,6S)-alpha-bergamotene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57977", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose => (20S)-ginsenoside C-K + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62619", "l": "a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose <=> a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50127", "l": "NAD(+) + resolvin D1 <=> 8-oxoresolvin D1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75698", "l": "2'-deoxycytidine(in) <=> 2'-deoxycytidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69318", "l": "allyl thiocyanate + sulfate => (Z)-N-(sulfonatooxy)prop-2-enimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30283", "l": "(-)-trans-permethrin + H2O = (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)", "d": []}, {"i": "EC:3.1.1.88", "l": "\"pyrethroid hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229132", "l": "AP4 binds APP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981892", "l": "Active G alpha (z) binds RGS proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879909", "l": "Activation of STAT5a/b by JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38873", "l": "pseudouridine(2457) in 23S rRNA => uridine(2457) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41658", "l": "NADPH + sanguinarine => dihydrosanguinarine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080062", "l": "cytokinin 9-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-9-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event."]}, {"i": "KEGG.REACTION:R08369", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22565", "l": "a 2,3-saturated acyl-[ACP] + NADP(+) => a (2E)-enoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69808", "l": "benzoyl-AMP + CoA => AMP + benzoyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.3", "l": "\"thiamine phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32939", "l": "a 1,2-diacyl-sn-glycerol + CDP-choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12046", "l": "a diacylglycerol + a fatty acid + H(+) => a triacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43972", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58934", "l": "5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+) => 4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701064", "l": "TRPV1 binds TRPV1 agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035612", "l": "AP-2 adaptor complex binding", "d": ["Binding to an AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17656", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655315", "l": "Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60473", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => (6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66248", "l": "CoA + IC-asc-C9-AMP = AMP + H(+) + IC-asc-C9-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11254", "l": "beta-L-aspartylhydroxamate + NH4(+) => H(+) + hydroxylamine + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31459", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate = 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate", "d": []}, {"i": "EC:5.3.99.10", "l": "\"thiazole tautomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042656", "l": "JUN kinase kinase kinase kinase activity", "d": ["Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27848", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+) => (2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16391", "l": "CO2 + H2O + hydroquinone + NAD(+) => 4-hydroxybenzoate + 2 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69723", "l": "(indol-3-yl)acetyl-AMP + CoA = (indol-3-yl)acetyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45341", "l": "[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O => (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74459", "l": "1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = 1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2152276", "l": "Secretion of transmembrane collagens (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12857", "l": "(2S,3S)-3-methyl-L-aspartate = L-glutamate", "d": []}, {"i": "EC:5.4.99.1", "l": "\"methylaspartate mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191763", "l": "snRNP:Snurportin complex formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9702818", "l": "CALCR binds erenumab (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351901", "l": "Caspase-mediated cleavage of MST3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40420", "l": "H2O + phytanoyl-CoA => 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28322", "l": "UDP-alpha-D-glucuronate + wogonin = UDP + wogonin 7-O-beta-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-622415", "l": "RIP2 binds NEMO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58630", "l": "FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal => FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443418", "l": "GP1b signaling involves c-Src (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22604", "l": "D-mannose = D-fructose", "d": []}, {"i": "EC:5.3.1.7", "l": "\"mannose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15350", "l": "L-glutamate + N(2)-acetyl-L-ornithine => L-ornithine + N-acetyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700149", "l": "Active ALK binds PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73447", "l": "acetyl-CoA(in) + AMP(out) = acetyl-CoA(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106226", "l": "peptide 2-hydroxyisobutyryltransferase activity", "d": ["Catalysis of the reaction: 2-hydroxyisobutyryl-CoA + lysine in peptide = CoA + N-2-hydroxyisobutyryl-lysine-peptide."]}, {"i": "RHEA:24180", "l": "2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64284", "l": "2-phenylethylamine + pyruvate = 2-phenylacetaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043776", "l": "cobalt-precorrin-6B C5-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosylmethionine + cobalt-precorrin 6B = S-adenosylhomocysteine + cobalt-precorrin 7."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033822", "l": "glucosyl-DNA beta-glucosyltransferase activity", "d": ["Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a glucosylhydroxymethylcytosine residue in DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781941", "l": "WNTs are secreted in exosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32366", "l": "L-gulono-1,4-lactone + O2 <=> H(+) + H2O2 + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8979071", "l": "KDM6B binds iron (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14428", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45448", "l": "H2O + N-(dodecanoyl)-sphinganine = dodecanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47365", "l": "a dodecanoate ester + H2O => an aliphatic alcohol + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031851", "l": "kappa-type opioid receptor binding", "d": ["Binding to a kappa-type opioid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39181", "l": "eicosanoyl-CoA + NADP(+) => (2E)-eicosenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29890", "l": "ATP + H2O + L-lysine(out) <=> ADP + H(+) + L-lysine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034815", "l": "cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity", "d": ["Catalysis of the reaction: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate = 10-oxabenzo(def)chrysen-9-one + formate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635842", "l": "ULK3 phosphorylates GLI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17614", "l": "NAD(+) + scyllo-inositol => H(+) + NADH + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48554", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) => 1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65634", "l": "an N-tetracosanoyl-sphingoid base + CoA + H(+) => a sphingoid base + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042392", "l": "sphingosine-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635843", "l": "GLI translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54507", "l": "all-trans-hexaprenyl diphosphate <=> beta-hexaprene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59268", "l": "A + H2O + N(6)-methyl-L-lysyl-[protein] = AH2 + formaldehyde + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381545", "l": "Formation of the IGF:IGFBP5:ALS complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173680", "l": "Activation of C5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381091", "l": "IRE1 dimer autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45427", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045295", "l": "gamma-catenin binding", "d": ["Binding to catenin complex gamma subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74000", "l": "dimethylallyl diphosphate + quinolinone B => diphosphate + peniprequinolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32171", "l": "H(+) + NADPH + O2 + phenylacetyl-CoA = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.149", "l": "\"phenylacetyl-CoA 1,2-epoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45946", "l": "4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050567", "l": "glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70707", "l": "6-sulfo-beta-D-quinovose = 6-sulfo-D-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19921", "l": "D-ribitol 5-phosphate + NADP(+) = D-ribulose 5-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31835", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-galactose", "d": []}, {"i": "EC:5.3.2.3", "l": "\"TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.3.2", "l": "\"beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:1902944", "l": "aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process", "d": ["Any aspartic-type endopeptidase activity that is involved in amyloid precursor protein catabolic process."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74213", "l": "L-threonine + tRNA(Lys) => H2O + L-threonyl-tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23409", "l": "NADP(+) + precorrin-6B => 2 H(+) + NADPH + precorrin-6A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57461", "l": "(E)-sinapyl alcohol + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63429", "l": "ATP + H2O + levoglucosan => ADP + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13233", "l": "guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632039", "l": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57793", "l": "3,4-dinitrotoluene + NADH + O2 => 4-methyl-6-nitrocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13116", "l": "2-acetamidofluorene + H2O + NADP(+) <=> H(+) + N-hydroxy-2-acetamidofluorene + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201341", "l": "Endocytosis of TRAM (TICAM2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37465", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102999", "l": "UDP-glucose:2-hydroxylamino-4,6-dinitrotoluene-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 2-hydroxylamino-4,6-dinitrotoluene <=> 2-hydroxylamino-4,6-dinitrotoluene-O-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16830", "l": "an aldehyde + H2O + O2 => a carboxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71923", "l": "2 Na(+)(out) + taurochenodeoxycholate(out) = 2 Na(+)(in) + taurochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10675", "l": "cyclobutadithymidine in DNA <=> a thymidine dimer in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57226", "l": "N(2)-(1-hydroxy-2-oxoethyl)-GTP => glyoxal + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10632", "l": "D-mannonate + NAD(+) = D-mannuronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004456", "l": "phosphogluconate dehydratase activity", "d": ["Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56571", "l": "globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine <=> globoside IV3GalNAc-Gb4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18336", "l": "ATP + oleandomycin <=> ADP + H(+) + oleandomycin 2'-O-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71960", "l": "3 Na(+)(out) + oxaloacetate(out) => 3 Na(+)(in) + oxaloacetate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43638", "l": "2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008650", "l": "rRNA (uridine-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine."]}, {"i": "REACT:R-HSA-6793127", "l": "MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12794", "l": "1D-myo-inositol hexakisphosphate + ATP => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68723", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56514", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate => 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22418", "l": "catechol + CO2 => 3,4-dihydroxybenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62163", "l": "H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate <=> N-(9Z-octadecenoyl) ethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64556", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one = 8-epi-ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203977", "l": "SAR1 Activation And Membrane Binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67332", "l": "13-cis-retinal + H2O + NAD(+) = 13-cis-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34768", "l": "5,10-methenyltetrahydrofolate + H2O => (6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67950", "l": "3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-901047", "l": "Binding of ERp57 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807872", "l": "Active ARF recruits coatomer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392834", "l": "Activation of EPACs by cAMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40104", "l": "H2O + propanoyl-CoA => CoA + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43155", "l": "adenosine(58) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604629", "l": "FBXW7 promotes ubiquitination of p-NICD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70781", "l": "6-dehydro-D-glucose + H(+) + NADPH => D-glucose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20278", "l": "acetyl-CoA + an N-hydroxyarylamine => an N-acetoxyarylamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62965", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose => alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54779", "l": "1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine <=> [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48552", "l": "1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = (9S,13S,15Z)-12-oxophyto-10-15-dienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936599", "l": "RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377644", "l": "Release of CSK from SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38183", "l": "19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] = 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48399", "l": "(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine <=> 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71190", "l": "3-hydroxy-L-kynurenine(out) + L-tryptophan(in) <=> 3-hydroxy-L-kynurenine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67314", "l": "myceliothermophin E => (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855375", "l": "PTPN22 dissociates from CSK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11586", "l": "D-ornithine => L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975160", "l": "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874079", "l": "PTK2 binds activated MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0010436", "l": "carotenoid dioxygenase activity", "d": ["Catalysis of the oxidative cleavage of carotenoids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944227", "l": "Association of procollagen type XXII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851979", "l": "BTNL9 binds immune cell surfaces (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46039", "l": "2'-deoxycytidine + UTP <=> dCMP + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23960", "l": "H(+) + 2 H2O2 + hexadecanoate = CO2 + 3 H2O + pentadecanal", "d": []}, {"i": "EC:1.11.1.3", "l": "\"fatty-acid peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63222", "l": "5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine => 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18075", "l": "AH2 + orotate => (S)-dihydroorotate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39939", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59801", "l": "decanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71962", "l": "3 Na(+)(out) + oxaloacetate(out) <=> 3 Na(+)(in) + oxaloacetate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61355", "l": "ATP + H2O + riboflavin(in) <=> ADP + H(+) + phosphate + riboflavin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58109", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] => acetate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202702", "l": "CD177 binds PECAM-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196026", "l": "Dab2 is recruited to the junctional plaques (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68350", "l": "diphosphate + pppA(2'-5')pG => ATP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424476", "l": "Activation of RAC1 by VAV2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74056", "l": "D-cysteine(out) + L-alanine(in) => D-cysteine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44475", "l": "1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33094", "l": "1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42669", "l": "L-rhamnofuranose + NADP(+) => H(+) + L-rhamnono-1,4-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047052", "l": "(S)-stylopine synthase activity", "d": ["Catalysis of the reaction: (S)-cheilanthifoline + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-stylopine + [oxidized NADPH--hemoprotein reductase] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626228", "l": "The distal appendage proteins recruit TTBK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37395", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64804", "l": "acetyl-CoA + S-(2-aminoethyl)-L-cysteine = CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-984689", "l": "Kinesin-7 is a dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187332", "l": "Cytosolic CMs translocate to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31284", "l": "FAD + H(+) + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3782637", "l": "HDAC8 deacetylates histones (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26074", "l": "H2O + UDP-alpha-D-glucuronate => D-glucuronate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74900", "l": "(2E)-2-butenoate + ATP + holo-[ACP] => (2E)-butenoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46348", "l": "(2E)-octenoyl-CoA + H2O = 3-hydroxyoctanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694737", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015347", "l": "sodium-independent organic anion transmembrane transporter activity", "d": ["Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67591", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10400", "l": "L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine", "d": []}, {"i": "EC:2.6.1.15", "l": "\"glutamine--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55747", "l": "coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57916", "l": "ATP + L-aspartyl-tRNA(Asn) = 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204861", "l": "Interaction of Tie2 and Shc1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14248", "l": "ATP + H2O <=> AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28567", "l": "3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP => 6 AMP + enterobactin + 7 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33210", "l": "ATP + H(+) + L-glutamate + NADPH <=> ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191072", "l": "Synthesis of Cx43 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050473", "l": "arachidonate 15-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74935", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2 2-oxoglutarate + 2 O2 = (3R)-3-isocyanylbutanoate + 3 CO2 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53339", "l": "5,6-dihydrouridine(20) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047470", "l": "(1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity", "d": ["Catalysis of the reaction: 4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-alpha-D-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucopyranoside."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030973", "l": "molybdate ion binding", "d": ["Binding to a molybdate ion (MoO4 2-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2430535", "l": "MASTL phosphorylates ENSA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186780", "l": "Degradation of Ub-SMAD7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035516", "l": "oxidative DNA demethylase activity", "d": ["Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52688", "l": "3-phenyllactate + NAD(+) = 3-phenylpyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247569", "l": "PADI4 deiminates Histones (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867135", "l": "CEACAM1,3,5,6 bind opa proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65968", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60747", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone <=> CoA + pyrethrin I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22436", "l": "(2E,6E)-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate", "d": []}, {"i": "EC:4.2.3.22", "l": "\"germacradienol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66342", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70604", "l": "4-hydroxystyrene + H(+) + NADH => 4-ethylphenol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12880", "l": "acetylacetone + O2 <=> acetate + H(+) + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0031877", "l": "somatostatin receptor binding", "d": ["Binding to a somatostatin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57035", "l": "(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O <=> CO2 + formate + methylamine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29028", "l": "2 H(+)(in) + L-glutamate(in) => 2 H(+)(out) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36428", "l": "2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28767", "l": "ethylnitronate + O2 = acetaldehyde + chemical entity + H(+) + nitrite", "d": []}, {"i": "EC:1.13.12.16", "l": "\"nitronate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60471", "l": "3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004499", "l": "N,N-dimethylaniline monooxygenase activity", "d": ["Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5246478", "l": "APOM binds retinoids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166726", "l": "Activation of MASPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53168", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55464", "l": "11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] = 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68144", "l": "ethyl 3-oxobutanoate + H(+) + NADPH = ethyl (R)-3-hydroxybutanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.38", "l": "\"FMN reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56146", "l": "a quinone + H2O + nitrite => a quinol + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22129", "l": "(1S,2R,4S)-borneol + NAD(+) => (1S,4S)-camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701064", "l": "TRPV1 binds TRPV1 agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71656", "l": "an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O => a thymidine in DNA + ADP-D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839107", "l": "BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69369", "l": "11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+) => 17beta-hydroxyandrost-4-ene-3,11-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47861", "l": "ganglioside GT1b (d18:1(4E)) + H2O => ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.19", "l": "\"aspergillopepsin II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.509227218911647", "identifiers": [{"i": "GO:0004620", "l": "phospholipase activity", "d": ["Catalysis of the hydrolysis of a glycerophospholipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018808", "l": "RAC3 binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60094", "l": "3-dehydro-4alpha-methylzymosterol + CO2 + NADH => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937177", "l": "AHR:TCDD binds ARNT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994038", "l": "IRF2 binds the promoters of Interferon alpha and beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381087", "l": "Dimerization of PERK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011748", "l": "IL9R binds JAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15925", "l": "dihydrobunolol + NADP(+) = bunolol + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.160", "l": "\"dihydrobunolol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58731", "l": "adenosine in rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61969", "l": "a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106365", "l": "beta-carotene isomerase activity", "d": ["Catalyzes the reaction: all-trans-beta-carotene = 9-cis-beta-carotene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59873", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211206", "l": "Translocation of DFF to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350901", "l": "Iodide is organified (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140696", "l": "factor V -> factor Va + factor V activation peptide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16901", "l": "acetyl-CoA + L-2,4-diaminobutanoate = (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.178", "l": "\"diaminobutyrate acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2529020", "l": "CK2 phosphorylates condensin I subunits (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046567", "l": "aphidicolan-16 beta-ol synthase activity", "d": ["Catalysis of the reaction: 9-alpha-copalyl diphosphate + H2O = aphidicolan-16-beta-ol + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1358791", "l": "Phosphorylation of USP8 by P-AKT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.15", "l": "\"D-glutamate(D-aspartate) oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710353", "l": "GSDMD (1-275) binds cardiolipin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9022314", "l": "HIPK2 phosphorylates MECP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49096", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine = 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine", "d": []}, {"i": "EC:1.21.98.3", "l": "\"anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21327", "l": "2 H(+) + reduced [rubredoxin] + superoxide <=> H2O2 + oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25899", "l": "H(+) + malonate <=> acetate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19444", "l": "benzene-1,2,4-triol + O2 <=> 3-hydroxy-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451310", "l": "Activation of Edited Kainate receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51279", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate <=> (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689861", "l": "Recruitment of XPA and release of CAK  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380586", "l": "loading of Serotonin in synaptic vesicles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52663", "l": "an L-alpha-amino acid + ATP + holo-[ACP] <=> AMP + an L-alpha-aminoacyl-[ACP] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186819", "l": "SH2 domain of Src binds to the active receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050231", "l": "putrescine carbamoyltransferase activity", "d": ["Catalysis of the reaction: carbamoyl phosphate + putrescine = N-carbamoylputrescine + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21134", "l": "H2O2 + urate => H2O + O2 + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58964", "l": "H2O + hexanal + O2 = H(+) + H2O2 + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23822", "l": "GDP-4-dehydro-alpha-D-rhamnose + H2O => GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018757", "l": "deisopropylhydroxyatrazine aminohydrolase activity", "d": ["Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60089", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) => a 4alpha-methyl-3-oxosteroid + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102145", "l": "(3R)-(E)-nerolidol synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O <=> (3R,6E)-nerolidol + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.109", "l": "\"arginine N-succinyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:1990239", "l": "steroid hormone binding", "d": ["Binding to a steroid hormone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48726", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide => aurachin B + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39920", "l": "1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O => 1-O-(alk-1-enyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17754", "l": "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine => (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004579", "l": "dolichyl-diphosphooligosaccharide-protein glycotransferase activity", "d": ["Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39230", "l": "(2E)-octacosenoyl-CoA + H(+) + NADPH <=> NADP(+) + octacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64683", "l": "benzoyl-CoA + ethanol <=> CoA + ethyl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847880", "l": "CYTH proteins bind ARF1:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018675", "l": "(S)-limonene 6-monooxygenase activity", "d": ["Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52310", "l": "2-oxoglutarate + H(+) + NADPH => 2-hydroxyglutarate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428609", "l": "Type I Na+-coupled phosphate co-transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018615", "l": "2-indanone monooxygenase activity", "d": ["Catalysis of the reaction: 2-indanone + NADPH + 1/2 O2 = NADP+ + 3-isochromanone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42817", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol => cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035718", "l": "macrophage migration inhibitory factor binding", "d": ["Binding to the cytokine, macrophage migration inhibitory factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42646", "l": "diphosphate + holo-[malonate decarboxylase ACP] => 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53790", "l": "allodeoxycholate + beta-muricholoyl-CoA => allodeoxycholoyl-CoA + beta-muricholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20442", "l": "L-cysteine + O2 => 3-sulfino-L-alanine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40829", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684096", "l": "CDK2 phosphorylates RBBP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72081", "l": "3 Na(+)(in) + selenate(in) => 3 Na(+)(out) + selenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43856", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23046", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10177", "l": "(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) => (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264615", "l": "Loading of acetylcholine in synaptic vesicles (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64797", "l": "H2O + L-lysine + NADP(+) => (S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35856", "l": "1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60254", "l": "acryloyl-CoA + CO2 + NADPH => (S)-methylmalonyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31838", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44916", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH = (3E)-decenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163672", "l": "Phosphorylation of ChREBP at Thr(653) by PKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686930", "l": "RIPK3 is cleaved by CASP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15219", "l": "CoA + ecdysone hexadecanoate => ecdysone + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16544", "l": "9-cis-violaxanthin + O2 <=> (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18608", "l": "1-amino-1-deoxy-scyllo-inositol + ATP <=> 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031575", "l": "AP-1 binds ARC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54776", "l": "1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine = [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5082391", "l": "Trimerization of HSF1 in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42988", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = cembrene C + diphosphate", "d": []}, {"i": "EC:4.2.3.148", "l": "\"cembrene C synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010284", "l": "lariciresinol reductase activity", "d": ["Catalysis of the reaction: lariciresinol + NADPH + H+ = secoisolariciresinol + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203774", "l": "Interaction of Csk with PAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33344", "l": "glycine + O2 => 2-iminoacetate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34123", "l": "3,5,7-trioxododecanoyl-CoA = CoA + H(+) + olivetolate", "d": []}, {"i": "EC:4.4.1.26", "l": "\"olivetolic acid cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655142", "l": "RCHY1 binds POLH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610879", "l": "GluN1 (GRIN1) binds to NEFL at postsynaptic density (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134962", "l": "DHX36 binds DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38436", "l": "(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50854", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27384", "l": "(2R)-2,3-bisphosphoglycerate + H2O <=> (2R)-2-phosphoglycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013110", "l": "RHOC binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23443", "l": "4-chlorobenzoate + H2O <=> 4-hydroxybenzoate + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9821368", "l": "AKAP8L binds MLL1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247839", "l": "Retromer associates with WLS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33386", "l": "(S)-malate + UDP-N-acetyl-alpha-D-glucosamine <=> (S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72672", "l": "The 60S subunit joins the translation initiation complex  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602484", "l": "Activation of proMMP11 by FURIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211461", "l": "HNF1A-dependent synthesis of the L isoform of PKLR protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693609", "l": "ATM phosphorylates TP53 at S15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73002", "l": "H2O + N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide] <=> L-tryptophan + N-terminal L-alpha-aminoacyl-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21676", "l": "2 dimethylallyl diphosphate = (R)-lavandulyl diphosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.69", "l": "\"lavandulyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031802", "l": "Maresins translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31682", "l": "O2 + prosolanapyrone II <=> H2O2 + prosolanapyrone III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5604929", "l": "Activated protein C binds Protein S (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75110", "l": "32-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0036041", "l": "long-chain fatty acid binding", "d": ["Binding to a long-chain fatty acid. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49068", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24961", "l": "apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2 => [excited state blue fluorescent protein] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37291", "l": "H2O + L-alanyl-L-leucine = L-alanine + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420688", "l": "GABAB heterodimeric receptor binds GABA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102518", "l": "(11Z)-eicosenoate 14-hydroxylase activity", "d": ["Catalysis of the reaction: (11Z)-eicosenoyl-CoA + NADH + O2 + H+ = lesqueroloyl-CoA + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352908", "l": "fructose 6-phosphate + ATP => fructose 2,6-bisphosphate + ADP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374701", "l": "Phosphorylation of DCC by Fyn (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6790454", "l": "SUMOylation of XPC (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032036", "l": "LTA4 translocates from neutrophil cytosol to platelet cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34730", "l": "H2O + N-acyl-15-methylhexadecasphinganine <=> 15-methylhexadecasphinganine + a carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59775", "l": "D-sorbitol + O2 <=> D-sorbopyranose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39314", "l": "(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4332235", "l": "CBL binds TGFBR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701557", "l": "AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21149", "l": "indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose => 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061815", "l": "Met1-linked polyubiquitin deubiquitinase activity", "d": ["Catalysis of the hydrolysis of ubiquitin units from Met1-linked (or linear) polyubiquitin chains."]}, {"i": "REACT:R-HSA-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16911", "l": "2 Fe(II)-[cytochrome c] + glyoxylate + 2 H(+) + NH4(+) => 2 Fe(III)-[cytochrome c] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0008308", "l": "voltage-gated monoatomic anion channel activity", "d": ["Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}, {"i": "REACT:R-HSA-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54986", "l": "a ubiquinone + 2 e(-) + 2 H(+) => a ubiquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814387", "l": "CASP14 cleaves filaggrin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102943", "l": "trans-2,3-dihydro-3-hydroxy-anthranilate isomerase activity", "d": ["Catalysis of the reaction: (2S,3S)-2,3-dihydro-3-hydroxyanthranilic acid = (1R,6S)-6-ammonio-5-oxocyclohex-2-ene-1-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49428", "l": "CTP + phosphonoformate = CMP-5'-phosphonoformate + diphosphate", "d": []}, {"i": "EC:2.7.7.93", "l": "\"phosphonoformate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40856", "l": "FAD + H(+) + undecanoyl-CoA => FADH2 + trans-2-undecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34808", "l": "(R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase] => camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626914", "l": "α2-agonists bind ADRA2A,B,C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592387", "l": "Fibulin binds elastic fibres (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60676", "l": "(S)-(-)-citronellol + NAD(+) = (S)-(-)-citronellal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20021", "l": "2-oxoglutarate + deoxyamidinoproclavaminate + O2 = amidinoproclavaminate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451900", "l": "IL2RB binds JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033958", "l": "DNA-deoxyinosine glycosylase activity", "d": ["Catalysis of the hydrolysis of DNA and polynucleotides, releasing free hypoxanthine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9770847", "l": "Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41844", "l": "(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58835", "l": "24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25180", "l": "4-methyl-2-oxopentanoate + CoA + NAD(+) <=> 3-methylbutanoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672019", "l": "Leucodopachrome, L-Dopaquinone transform to Dopachrome, L-Dopa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33232", "l": "H2O2 + heme b => heme d cis-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682992", "l": "KDM4A,B bind H4K20Me2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42772", "l": "guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.179", "l": "\"16S rRNA (guanine(1405)-N(7))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27655", "l": "2-oxobutanoate + H(+) + pyruvate => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57741", "l": "a 2,3-saturated meromycolyl-[ACP] + NAD(+) => a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18093", "l": "5,6-dihydrouracil + NADP(+) = H(+) + NADPH + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014467", "l": "RHOG binds effectors at the ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015530", "l": "shikimate transmembrane transporter activity", "d": ["Enables the transfer of shikimate from one side of a membrane to the other. Shikimate is an important intermediate in the biosynthesis of aromatic amino acids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5685230", "l": "CHEK1 phosphorylates RAD51 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199169", "l": "MHC Class I interacts with CD160 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43322", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-378956", "l": "Luteinizing hormone is a heterodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210426", "l": "Glutamate synaptic vesicle docking and priming (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19374", "l": "H2O + L-saccharopine + NADP(+) => 2-oxoglutarate + H(+) + L-lysine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21591", "l": "N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate <=> H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474266", "l": "Formation of collagen fibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18960", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68610", "l": "Formation of ORC(2-5) complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33868", "l": "(S)-2-ureidoglycine + glyoxylate => glycine + N-carbamoyl-2-oxoglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451535", "l": "Dimerization of activated ERK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51763", "l": "a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate <=> a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205649", "l": "p62 links damaged mitochondria to LC3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.4.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218820", "l": "Src kinases phosphorylate VAV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21395", "l": "2-phenylacetaldehyde + H2O + NAD(+) <=> 2-phenylacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49056", "l": "asperlicin C + H(+) + NADPH + O2 = asperlicin E + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266303", "l": "Spherical HDL binds C and E apolipoproteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52239", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + Fe(2+) + 3 H2O + mycobilin b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40138", "l": "(9Z)-tetradecenoyl-CoA + H2O <=> (9Z)-tetradecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111915", "l": "CAMK4 autophosphorylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388817", "l": "ICOS binds ICOSL/B7-H2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12166", "l": "adenosine 3',5'-bisphosphate + an aryl sulfate + H(+) => 3'-phosphoadenylyl sulfate + a phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63837", "l": "hexadecanoate + O2 => (2R)-2-hydroperoxyhexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35076", "l": "doxorubicin(in) + H(+)(out) => doxorubicin(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003854", "l": "3-beta-hydroxy-delta5-steroid dehydrogenase activity", "d": ["Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36549", "l": "CoA + H(+) + N-(octadecanoyl)-sphinganine => octadecanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678854", "l": "S1PR1 binds S1PR1 agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40076", "l": "6-amino-6-deoxyfutalosine + H(+) + H2O => futalosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247849", "l": "WLS dissociates from retromer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480509", "l": "Expression of EPHA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868071", "l": "Clathrin recruits PIK3C2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21030", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein] => acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947535", "l": "Cyclisation of GTP to precursor Z (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69339", "l": "(E)-alk-1-en-1-SO-peroxol <=> (Z)-alkanethial oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44807", "l": "1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-9 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380930", "l": "Phosphorylated AMPK binds AMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218836", "l": "PTK2beta binds alphaVbeta3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614933", "l": "ACEIs bind ACE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32185", "l": "cholest-5-en-3-one + H2O2 => cholesterol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120170", "l": "intraciliary transport particle B binding", "d": ["Binding to an intraciliary transport particle B (IFT B) complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.94", "l": "\"proprotein convertase 2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61442", "l": "CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine => acetyl-CoA + S-(2-succino)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2173318", "l": "C5a anaphylatoxin binds C5a receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102967", "l": "10-hydroxygeraniol oxidoreductase activity", "d": ["Catalysis of the reaction: (6E)-8-hydroxygeraniol + NADP <=> (6E)-8-hydroxygeranial + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174731", "l": "Degradation of newly synthesized ApoB-48 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050593", "l": "N-methylcoclaurine 3'-monooxygenase activity", "d": ["Catalysis of the reaction: (S)-N-methylcoclaurine + H+ + NADPH + O2 = (S)-3'-hydroxy-N-methylcoclaurine + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21116", "l": "D-maltose + phosphate = beta-D-glucose 1-phosphate + D-glucose", "d": []}, {"i": "EC:2.4.1.8", "l": "\"maltose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67850", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + AMP + diphosphate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004808", "l": "tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51364", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349626", "l": "Integrin alpha2beta1 binds laminin-332 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46757", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592398", "l": "Activation of proMMP8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74905", "l": "(2E)-but-2-enoyl-AMP + diphosphate => (2E)-2-butenoate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419254", "l": "5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055131", "l": "C3HC4-type RING finger domain binding", "d": ["Binding to a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74986", "l": "Elongation of pre-rRNA transcript (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71004", "l": "L-histidine(in) + L-phenylalanine(out) => L-histidine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72502", "l": "2-oxoglutarate(in) + prostaglandin E2(out) <=> 2-oxoglutarate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65945", "l": "AH2 + CTP + S-adenosyl-L-methionine => 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156682", "l": "PLK1 phosphorylates NUDC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35810", "l": "2-dehydro-3-deoxy-D-arabinonate <=> 2,5-dioxopentanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983707", "l": "SYK autophosphorylates at the activated BCR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43734", "l": "1,3-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32984", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69424", "l": "2-hydroxyisobutanoyl-CoA = acetone + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18944", "l": "a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) <=> a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004019", "l": "adenylosuccinate synthase activity", "d": ["Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71440", "l": "L-dopa(out) + L-phenylalanine(in) => L-dopa(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762097", "l": "MYC binds the NFE2L2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0004731", "l": "purine-nucleoside phosphorylase activity", "d": ["Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71027", "l": "L-glutamine(in) + L-phenylalanine(out) = L-glutamine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57003", "l": "acetyl-CoA + streptothricin F <=> CoA + H(+) + N(beta)-acetylstreptothricin F", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008847", "l": "Enterobacter ribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202394", "l": "Translocation of CARMA1 to Plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65180", "l": "AH2 + O2 + protoaustinoid B = A + H2O + preaustinoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196753", "l": "2xPPCS ligates PPanK with Cys (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420121", "l": "SFKs phosphorylate PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49895", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 <=> (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31584", "l": "2-oxo-dATP + H2O => 2-oxo-dAMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14438", "l": "H2O + L-lysine + O2 => 6-amino-2-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12177", "l": "phenylethanolamine + S-adenosyl-L-methionine => H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11054", "l": "4-aminophenol + CO2 + H2O + NAD(+) => 4-aminobenzoate + 2 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696271", "l": "RND1 binds effectors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0005201", "l": "extracellular matrix structural constituent", "d": ["The action of a molecule that contributes to the structural integrity of the extracellular matrix."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58517", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37846", "l": "1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951486", "l": "CD46 binds C4b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61054", "l": "(-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50923", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 <=> chromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177923", "l": "Sustained activation of SRC kinase by SHP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026510", "l": "NTF4-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65042", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + a tri-(9Z,12Z-octadecadienoyl)-monolysocardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0019972", "l": "interleukin-12 binding", "d": ["Binding to interleukin-12."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38210", "l": "19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13972", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + GTP <=> a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + diphosphate + GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59317", "l": "D-cellobiose + O2 => D-cellobiono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63722", "l": "losartan-2-N-beta-D-glucuronide + UDP => losartan + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26053", "l": "glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211650", "l": "Autophosphorylation of PAK-2p34 in the activation loop (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41538", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine => 2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42861", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + H2O => 1,2-dioctanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68275", "l": "a fatty acyl-CoA + L-seryl-[protein] <=> CoA + O-fatty acyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814764", "l": "Plasma membrane resorption (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58963", "l": "benzaldehyde + H2O + O2 <=> benzoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53394", "l": "(2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36284", "l": "1,7-dimethylxanthine + H(+) + NADPH + O2 => 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33875", "l": "cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49042", "l": "(-)-yatein + H(+) + S-adenosyl-L-homocysteine => (-)-5'-demethylyatein + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27582", "l": "(S)-2-hydroxymethylglutarate = 2-methyleneglutarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65505", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O => 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65837", "l": "AH2 + ATP + 2 Co(II)-[trimethylamine-specific corrinoid protein] + H2O => A + ADP + 2 Co(I)-[trimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13483", "l": "AMP + diphosphate + L-methionyl-tRNA(Met) => ATP + L-methionine + tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388828", "l": "PD-1 binds B7DC and B7H1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047388", "l": "[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase", "d": ["Catalysis of the reaction: adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] + H2O = AMP + [L-glutamate:ammonia ligase (ADP-forming)]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36261", "l": "an aldehyde + glycerol => a 1-(1-hydroxyalkyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674385", "l": "p-T,Y MAPKs dimerize (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22522", "l": "all-trans-retinoate + H(+) + H2O2 => all-trans-retinal + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.303328383464915", "identifiers": [{"i": "GO:0019955", "l": "cytokine binding", "d": ["Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53208", "l": "daidzein + O2 + reduced [NADPH--hemoprotein reductase] = 2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15867", "l": "4-hydroxytryptamine + A + H2O => AH2 + O2 + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40515", "l": "6-deoxy-6-sulfo-D-fructose 1-phosphate = (2S)-3-sulfolactaldehyde + dihydroxyacetone phosphate", "d": []}, {"i": "EC:4.1.2.57", "l": "\"sulfofructosephosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029273", "l": "PI3K binds to p-6Y-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048307", "l": "ferredoxin-nitrite reductase activity", "d": ["Catalysis of the reaction: NH3 + 2 H2O + 6 oxidized ferredoxin = nitrite + 6 reduced ferredoxin + 7 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58769", "l": "1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27570", "l": "ATP + D-glycero-alpha-D-manno-heptose 7-phosphate = ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.168", "l": "\"D-glycero-alpha-D-manno-heptose-7-phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21321", "l": "A + D-sorbitol => AH2 + keto-L-sorbose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61774", "l": "H(+) + rebaudioside D + UDP => rebaudioside E + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69127", "l": "Formation of the Flap Intermediate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635102", "l": "GPR161 is internalized (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70182", "l": "2 D-maltotetraose <=> alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59262", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48579", "l": "4-chlorocatechol + O2 <=> 3-chloro-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853792", "l": "RET tyrosine phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033871", "l": "[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate; modifies selected glucosamine residues preceded by GlcA2S."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322422", "l": "Beta-catenin recruits SMARCA4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44055", "l": "alpha,alpha-trehalose + hexadecanoyl-CoA <=> 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53732", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate = 2-hydroxy-7,8-dihydropteroate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13240", "l": "D-fructose 6-phosphate + L-glutamine <=> D-glucosamine 6-phosphate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18444", "l": "D-dopachrome + H(+) <=> 5,6-dihydroxyindole + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2545196", "l": "FN1 dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186773", "l": "PDGF dimer binds two receptors simultaneously (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798257", "l": "PTPRS binds NTRK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.5", "l": "\"carboxypeptidase C\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23420", "l": "alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate", "d": []}, {"i": "EC:3.1.3.12", "l": "\"trehalose-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018569", "l": "hydroquinone 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: hydroquinone + O2 = cis,trans-4-hydroxymuconic semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44051", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48372", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483089", "l": "PE is converted to PS by PTDSS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74544", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (E,E,E)-alpha-springene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40773", "l": "(20S)-ginsenoside F1 + D-glucose => (20S)-ginsenoside Rg1 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004734", "l": "pyrimidodiazepine synthase activity", "d": ["Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875558", "l": "RAPGEF1 binds CRK,CRKL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.178", "l": "\"beta-porphyranase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140610", "l": "RNA sequestering activity", "d": ["Binding to a specific RNA molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373724", "l": "Nephrin binds NCK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682026", "l": "MRN bound to shortened telomeres activates ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64672", "l": "2-(methylsulfanyl)acetyl-CoA + butan-1-ol = butyl 2-(methylsulfanyl)acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45839", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000399", "l": "RANBP2 SUMOylates SP100 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.10", "l": "\"ferric-chelate reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18085", "l": "coenzyme B + coenzyme M + methanophenazine = coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine", "d": []}, {"i": "EC:1.8.98.1", "l": "\"dihydromethanophenazine:CoB--CoM heterodisulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58144", "l": "acetate + ATP + cytidine(34) in elongator tRNA(Met) = AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.45", "l": "\"complement factor I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20961", "l": "1D-myo-inositol hexakisphosphate + H2O => 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25398", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0032454", "l": "histone H3K9 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353277", "l": "Cleavage of thymine by 5-methylcytosine G/T mismatch specific glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018700", "l": "2-chloro-N-isopropylacetanilide reductive dehalogenase activity", "d": ["Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + H+ + 2 e- = Cl- + N-isopropylacetanilide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391934", "l": "DP2 receptor can bind PGD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54610", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein] => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-517674", "l": "p-S158,221-HuR binds mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43829", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0140666", "l": "annealing activity", "d": ["An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule."]}, {"i": "REACT:R-HSA-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102056", "l": "11-hydroxyjasmonate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + an 11-hydroxyjasmonate <=> adenosine 3',5'-bismonophosphate + H+ + an 11-hydroxyjasmonate sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158313", "l": "factor XII -> factor XIIa (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66899", "l": "4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62362", "l": "(Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+) => FMN-N(5)-peroxide + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43386", "l": "ADP + H(+) + N(omega)-phospho-L-arginyl-[protein] => ATP + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050341", "l": "thymine dioxygenase activity", "d": ["Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018612", "l": "dibenzothiophene dioxygenase activity", "d": ["Catalysis of the reaction: dibenzothiophene + NADH + O2 + H+ = NAD+ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982645", "l": "GRKs bind ADRB2:Catecholamine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196964", "l": "RFK:Mg2+ phosphorylates RIB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40557", "l": "dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+) => dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52210", "l": "H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] => alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69934", "l": "inosine(out) + Na(+)(out) <=> inosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37137", "l": "1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68610", "l": "Formation of ORC(2-5) complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45680", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) = N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938773", "l": "RNF144A polyubiquitinates PRKDC (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610723", "l": "GLI proteins bind SUFU (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106371", "l": "fluorescent chlorophyll catabolite monooxygenase (deformylase) activity", "d": ["Catalysis of the reaction: O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] = formate + 2 H+ + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite."]}, {"i": "RHEA:67172", "l": "O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] = formate + 2 H(+) + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47000", "l": "H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.6.1.4", "l": "\"NAD(P)(+) transhydrogenase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.37", "l": "\"saccharolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27446", "l": "NADP(+) + xylitol => D-xylose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33045", "l": "(+)-6-exo-hydroxycamphor + H2O + NADP(+) => (1R,4R)-camphor + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63348", "l": "ATP + L-amino acyl-L-cysteinyl-[protein] = (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60914", "l": "H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218847", "l": "PAK2 binds NCK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734697", "l": "Expression of SMYD1 (BOP) in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24470", "l": "H2O + N,N-dimethylaniline N-oxide + NADP(+) => H(+) + N,N-dimethylaniline + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879594", "l": "SLCO4C1 mediates the transport of digoxin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36483", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624951", "l": "TNPO1 binds KIF17 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20204", "l": "ATP + H2O + L-phenylalanine <=> AMP + D-phenylalanine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50465", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH => 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050656", "l": "3'-phosphoadenosine 5'-phosphosulfate binding", "d": ["Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28211", "l": "H2O + L-saccharopine + O2 => (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69261", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate => (3R)-3-hydroxy-3-(thiiran-2-yl)propanenitrile + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687115", "l": "MYC positively regulates MAPKAPK5 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43494", "l": "chlorophyll b + H(+) + NADPH => 7(1)-hydroxychlorophyll a + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28468", "l": "pyridoxamine(out) => pyridoxamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001010", "l": "RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity", "d": ["The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49387", "l": "(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64315", "l": "2 chloride + 2 FADH2 + 2 O2 + sulochrin <=> dihydrogeodin + 2 FAD + H(+) + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167478", "l": "Abortive termination of HIV-1 early transcription elongation by DSIF:NELF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66755", "l": "(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O <=> (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433418", "l": "Phosphorylation of JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72095", "l": "Internal Methylation of mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33702", "l": "C20 sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0042876", "l": "aldarate transmembrane transporter activity", "d": ["Enables the transfer of aldarate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8934465", "l": "SHC1 binds PTPN12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047645", "l": "alkan-1-ol dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: primary alcohol + acceptor = aldehyde + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781941", "l": "WNTs are secreted in exosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75684", "l": "(12R,13S)-epoxy-(9Z)-octadecenoate + O2 => (12R,13S)-epoxy-(10R)-hydroperoxy-(8E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48108", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.320", "l": "\"type II protein arginine methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008254", "l": "3'-nucleotidase activity", "d": ["Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264622", "l": "Cho is acetylated to AcCho by CHAT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50400", "l": "L-cysteinyl-[PqsC protein] + octanoyl-CoA = CoA + S-octanoyl-L-cysteinyl-[PqsC protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14124", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11320", "l": "UDP-beta-L-arabinopyranose = UDP-alpha-D-xylose", "d": []}, {"i": "EC:5.1.3.5", "l": "\"UDP-arabinose 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24974", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin] => calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62844", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose = beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0036441", "l": "2-dehydropantolactone reductase activity", "d": ["Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621032", "l": "EGR1 binds the TPH1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199298", "l": "AKT phosphorylates CREB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661161", "l": "USP9X:SNCA dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64255", "l": "glycine + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3204311", "l": "AOX1 oxidises PXL to PDXate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15599", "l": "a Fe(III)-siderophore(in) + ADP + H(+) + phosphate => a Fe(III)-siderophore(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327803", "l": "Laminins bind Nidogens 1, 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52086", "l": "13-hydroxy-octadecanoate + H(+) + octadecanoate => 13-octadecanoyloxy-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35350", "l": "3-hydroxyoctadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30937", "l": "beta-D-ribosylnicotinate + phosphate => H2O + nicotinate beta-D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690873", "l": "ACO1 binds 4Fe-4S (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391941", "l": "BLT receptors can bind LTB4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602466", "l": "Activation of MT-MMPs by FURIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110307", "l": "REV1 binds AP-dsDNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014467", "l": "RHOG binds effectors at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033296", "l": "rhamnose binding", "d": ["Binding to the D- or L-enantiomer of rhamnose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61044", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.27", "l": "\"coagulation factor XIa\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52485", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A => (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44997", "l": "(R)-carnitine + acetoacetyl-CoA => CoA + O-3-oxobutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139842", "l": "Binding of Syk tyrosine kinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52413", "l": "4-phospho-D-erythronate + NAD(+) => 3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23554", "l": "2-hydroxy-2-methylpropanal + H(+) + NADH => 2-methylpropane-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51539", "l": "L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23255", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O <=> [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.243", "l": "\"6(G)-fructosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396399", "l": "Fibrillins bind BMPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29553", "l": "alpha-D-galactose 1-phosphate + 2 H(+) + UMP => H2O + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803858", "l": "TP53 binds the SFN gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618394", "l": "ARL4C gene transcription regulated by NR1H2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016309", "l": "1-phosphatidylinositol-5-phosphate 4-kinase activity", "d": ["Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854209", "l": "TBC1D10A binds JFC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72572", "l": "dehydroepiandrosterone 3-sulfate(in) + pentanoate(out) => dehydroepiandrosterone 3-sulfate(out) + pentanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25009", "l": "N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051061", "l": "ADP reductase activity", "d": ["Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46878", "l": "[(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+) => [(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948034", "l": "FGR binds LDL:LRP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55368", "l": "(R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30638", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38010", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine <=> 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43560", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29342", "l": "(S)-malate(in) + 2 H(+)(in) <=> (S)-malate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34041", "l": "6'-oxoparomamine + L-glutamate => 2-oxoglutarate + neamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40125", "l": "an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10650", "l": "6-hydroxyhexan-6-olide + H2O + NADP(+) => 2-hydroxycyclohexan-1-one + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9007447", "l": "E2F6 forms the PRC1L4 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56650", "l": "3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH => 3-oxochol-4-en-24-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11633", "l": "AH2 + L-selenocysteine => A + H(+) + hydrogenselenide + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31022", "l": "4 AH2 + all-trans-4,4'-diapolycopene + 4 O2 <=> 4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61605", "l": "[DsbA protein]-dithiol + [DsbB protein]-disulfide => [DsbA protein]-disulfide + [DsbB protein]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38067", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49367", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) <=> 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67985", "l": "N-acetyl-L-leucine => N-acetyl-D-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40710", "l": "(9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate <=> 1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452097", "l": "Recruited STAT5 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2581488", "l": "SAG binds p-MII to form p-MII:SAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27515", "l": "H2O + sphinganine 1-phosphate => phosphate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68007", "l": "AH2 + chloroethene <=> A + chloride + ethene + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802973", "l": "PLK3 phosphorylates CDC25C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32588", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 => (3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74265", "l": "n H(+)(in) + spermine(out) => n H(+)(out) + spermine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757578", "l": "ALB binds PREDN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30642", "l": "(R)-glycerate + GDP-alpha-D-mannose <=> (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56894", "l": "NADP(+) + UDP-beta-L-rhamnose => H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14329", "l": "2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.31", "l": "\"L-aminoadipate-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20000", "l": "H2O + phosphoenolpyruvate <=> phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10304", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.40", "l": "\"acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73800", "l": "SAICAR => AICAR + Fumarate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109813", "l": "GRB2-1 binds SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62896", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052668", "l": "CTP:farnesol kinase activity", "d": ["Catalysis of the reaction: 2-trans,-6-trans-farnesol + CTP = 2-trans,-6-trans-farnesyl monophosphate + CDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74549", "l": "diphosphate + talarodiene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15068", "l": "H2O + N(4)-benzoylagmatine <=> agmatine + benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5252133", "l": "ATP6AP1 binds V-ATPase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419861", "l": "Melanospin is stimulated by light (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36496", "l": "alpha-D-glucose + ATP => ADP + alpha-D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14131", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH => cholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24982", "l": "3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate => 3-hydroxy-4-methylanthranilate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45026", "l": "7-dehydrocholesterol + 2 H2O + NADP(+) => cholesterol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15798", "l": "bilirubin IXalpha + NAD(+) => biliverdin IXalpha + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56038", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27271", "l": "CoA + hexadecanal + NADP(+) => H(+) + hexadecanoyl-CoA + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047018", "l": "indole-3-acetaldehyde reductase (NADH) activity", "d": ["Catalysis of the reaction: indole-3-ethanol + NAD+ = (indol-3-yl)acetaldehyde + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48311", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O <=> (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943279", "l": "GGT dimers hydrolyse GSH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63420", "l": "2-hydroxyethylphosphonate + CTP = cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate", "d": []}, {"i": "EC:2.7.7.104", "l": "\"2-hydroxyethylphosphonate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17901", "l": "S-adenosyl-L-methionine + xanthotoxol = H(+) + S-adenosyl-L-homocysteine + xanthotoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70408", "l": "[(2E,6E,10E)-geranylgeranyl]-L-cysteine + H2O + O2 => (2E,6E,10E)-geranylgeranial + H2O2 + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50727", "l": "(E)-4-hydroxyphenylacetaldehyde oxime <=> (Z)-(4-hydroxyphenyl)acetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432295", "l": "GPVI binds Fyn and Lyn (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29478", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-cubenene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29430", "l": "(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) <=> (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032034", "l": "myosin II head/neck binding", "d": ["Binding to the head/neck region of a myosin II heavy chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67727", "l": "CMP(out) + CMP-N-acetyl-beta-neuraminate(in) <=> CMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336443", "l": "LIN7, CASK and APBA1 bind (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170799", "l": "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21061", "l": "3,4-dichloroaniline + malonyl-CoA => CoA + N-(3,4-dichlorophenyl)malonamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071972", "l": "peptidoglycan L,D-transpeptidase activity", "d": ["Catalysis of the reaction: 2 a peptidoglycan dimer (tetrapeptide) + 3 H2O = a peptidoglycan tetramer with L,D cross-links (L-Lys-D-Asn-L-Lys) + di-trans,poly-cis-undecaprenyl diphosphate + 4 D-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71806", "l": "acetate(out) + H(+)(out) <=> acetate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48823", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 <=> 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070878", "l": "primary miRNA binding", "d": ["Binding to a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60964", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose = (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32416", "l": "(1S,2S,4R)-isodihydrocarveol + NAD(+) => (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.247", "l": "\"stachydrine N-demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36470", "l": "H2O + L-alanylglycine <=> glycine + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52636", "l": "2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 = a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27287", "l": "(S)-acetoin + NAD(+) => diacetyl + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71356", "l": "5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out) => 5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940561", "l": "MMP7 cleaves OPTC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70981", "l": "4-aminobutanoate(in) + n H(+)(out) => 4-aminobutanoate(out) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736979", "l": "p-2S-SMAD2,3:SMAD4:SP1 binds CDKN2B gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047465", "l": "N-acylglucosamine-6-phosphate 2-epimerase activity", "d": ["Catalysis of the reaction: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69038", "l": "3beta-hydroxy-5beta-androstane-17-one + NADP(+) => 5beta-androstane-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10774", "l": "D-glucose + D-glucose 6-phosphate => 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806831", "l": "CYB5Rs reduce MetHb to HbA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33780", "l": "6-kestotriose + sucrose => 6,6-kestotetraose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57780", "l": "2-chloro-4-nitrotoluene + NADH + O2 = 3-chloro-4-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753634", "l": "GGT dimers hydrolyse APAP-SG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682598", "l": "ATM phosphorylates HERC2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30757", "l": "ADP + carbamoyl phosphate => ATP + carbamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928646", "l": "EPHAs bind EFNAs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55197", "l": "2-hydroxyoctadecanoyl-CoA => formyl-CoA + heptadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30906", "l": "demethylspheroidene + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + spheroidene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59586", "l": "ADP + beta-alanyl-L-lysine + H(+) + phosphate => ATP + beta-alanine + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18768", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1,2-diacyl-sn-glycerol + a sphingomyelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682863", "l": "RNF168 binds DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653974", "l": "Ragulator binds Rag dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804100", "l": "HMGB1 binds LPS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11178", "l": "beta-D-glucose 1-phosphate + D-glucose => kojibiose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58105", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769014", "l": "NPAS4 stimulates GEM gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103033", "l": "beta-galactosidase activity (lactose isomerization)", "d": ["Catalysis of the reaction: alpha-lactose = beta-(1->6)-galactobiose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140696", "l": "factor V -> factor Va + factor V activation peptide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46103", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> cortisol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11878", "l": "15-oxoprostaglandin E2 + H(+) + NADH => NAD(+) + prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57263", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP <=> GDP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0051377", "l": "mannose-ethanolamine phosphotransferase activity", "d": ["Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor."]}, {"i": "REACT:R-HSA-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71615", "l": "(S)-malate(in) + sulfate(out) = (S)-malate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757574", "l": "ALB binds PREDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22280", "l": "O-demethylpuromycin + S-adenosyl-L-methionine = H(+) + puromycin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.38", "l": "\"O-demethylpuromycin O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68192", "l": "decanoyl-CoA + phytol = CoA + decanoate phytyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48382", "l": "a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+) => alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34459", "l": "8-hydroxycopalyl diphosphate + H2O = diphosphate + sclareol", "d": []}, {"i": "EC:4.2.3.141", "l": "\"sclareol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31168", "l": "(3S)-hydroxytetradecanoyl-CoA + NAD(+) => 3-oxotetradecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183122", "l": "Factor D cleaves C3b-bound Factor B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605768", "l": "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31567", "l": "bisphenol A + H(+) + NADH + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1168376", "l": "STIM1 oligomerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917696", "l": "Cargo Sequestration (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73290", "l": "(2S)-naringenin + S-adenosyl-L-methionine <=> (2S)-naringenin 4'-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61521", "l": "AH2 + dopamine => 3-tyramine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.69", "l": "\"8-oxo-(d)GTP phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114684", "l": "Phosphorylation of Syntaxin-4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34337", "l": "(22R)-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin] => cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45347", "l": "globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> globoside NORint (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0000703", "l": "oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity", "d": ["Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25267", "l": "2-phenylacetaldehyde + H2O2 + NH4(+) => 2-phenylethylamine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51289", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396382", "l": "NOTCH1 Coactivator Complex binds promoters of HEY genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0099589", "l": "serotonin receptor activity", "d": ["Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61604", "l": "[DsbA protein]-dithiol + [DsbB protein]-disulfide = [DsbA protein]-disulfide + [DsbB protein]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15419", "l": "CO2 + L-tyrosine + NADPH => L-arogenate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665998", "l": "MKL1 binds SRF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66098", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine => 3-phenylpyruvate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57444", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine", "d": []}, {"i": "EC:3.4.17.17", "l": "\"tubulinyl-Tyr carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41199", "l": "1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52617", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP => 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16841", "l": "precorrin-2 + S-adenosyl-L-methionine = H(+) + precorrin-3A + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.130", "l": "\"precorrin-2 C(20)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848023", "l": "Activated PTK6 binds STAP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64997", "l": "ATP + H(+) + octanoate => diphosphate + octanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045294", "l": "alpha-catenin binding", "d": ["Binding to catenin complex alpha subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658430", "l": "NF1 is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41025", "l": "1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23229", "l": "L-lysine + NADPH + O2 => H2O + N(6)-hydroxy-L-lysine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51615", "l": "(R)-2-hydroxyglutarate + oxaloacetate <=> (R)-malate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48423", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) <=> CMP + ganglioside GM1 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56391", "l": "(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 <=> (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034832", "l": "geranial dehydrogenase activity", "d": ["Catalysis of the reaction: geranial + NAD+ + OH- = geranylate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47367", "l": "a dodecanoate ester + H2O <=> an aliphatic alcohol + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36233", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48435", "l": "ATP + N(6)-D-ribulosyl-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12460", "l": "(S)-malate = fumarate + H2O", "d": []}, {"i": "EC:4.2.1.2", "l": "\"fumarate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20438", "l": "5D-5-O-methyl-chiro-inositol + NADP(+) => 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36098", "l": "S-adenosyl-L-methionine + salicylate <=> methyl salicylate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21031", "l": "acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.939870552020253", "identifiers": [{"i": "GO:0016866", "l": "intramolecular transferase activity", "d": ["Catalysis of the transfer of a functional group from one position to another within a single molecule."]}, {"i": "EC:5.4.-.-", "l": "\"Intramolecular transferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165034", "l": "Rev multimer-bound  HIV mRNA:CRM1 complex associates with Ran:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213241", "l": "Formation of nonameric complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46427", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827999", "l": "SOX17 binds the TET2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9676257", "l": "Formation of the SET1A complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24333", "l": "3alpha-hydroxy-3,5-dihydromonacolin L carboxylate => H2O + monacolin L carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964619", "l": "PAK1 binds ARHGEF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619542", "l": "AMPK negatively regulates binding of MAPT to microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27403", "l": "(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate => 2-hydroxychromene-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13898", "l": "chorismate => prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191784", "l": "snRNA Cap hypermethylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199910", "l": "MSK1 activates ATF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72599", "l": "N-acetyl-L-aspartyl-L-glutamate(out) = N-acetyl-L-aspartyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159773", "l": "Furin cleaves pro-protein S to protein S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964531", "l": "TOP2A gene gene expression is repressed by the DREAM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13208", "l": "a monosaccharide 1-phosphate + H(+) + UTP <=> a UDP-monosaccharide + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59347", "l": "D-maltose + O2 <=> D-maltobiono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "51.063464113921214", "identifiers": [{"i": "GO:0005515", "l": "protein binding", "d": ["Binding to a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28877", "l": "H(+)(out) + L-tyrosine(out) => H(+)(in) + L-tyrosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38844", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41100", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395412", "l": "Phosphorylation of SYK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37804", "l": "a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26041", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+) => beta-D-fructose 6-phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "64.822718409361997", "identifiers": [{"i": "GO:0016836", "l": "hydro-lyase activity", "d": ["Catalysis of the cleavage of a carbon-oxygen bond by elimination of water."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693356", "l": "CEMIP hydrolyses HA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5622129", "l": "FABP5 binds atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35559", "l": "H(+) + menaquinone-7 + NADH = menaquinol-7 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102483", "l": "scopolin beta-glucosidase activity", "d": ["Catalysis of the reaction: H2O + scopolin <=> beta-D-glucose + scopoletin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698754", "l": "p-STAT5 binds the NOX4 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030623", "l": "U5 snRNA binding", "d": ["Binding to a U5 small nuclear RNA (U5 snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210277", "l": "Interaction of PECAM-1 and SHP-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70596", "l": "GOT2 dimer deaminates L-Asp (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58781", "l": "a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine => a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35280", "l": "acetyl-CoA + hexadecanoyl-CoA => 3-oxooctadecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15242", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5340214", "l": "CYGB binds O2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53007", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0071916", "l": "dipeptide transmembrane transporter activity", "d": ["Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53667", "l": "(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+) <=> H(+) + 2 H2O + pyridinestrone carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452838", "l": "Expression of NANOG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5159250", "l": "ATF7IP binds SETDB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34469", "l": "diphosphate + valerena-4,7(11)-diene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69112", "l": "glyoxylate + L-2-aminoadipate = 2-oxoadipate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783681", "l": "LIF binds LIFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13141", "l": "2-methylpropanoyl-CoA = butanoyl-CoA", "d": []}, {"i": "EC:5.4.99.13", "l": "\"isobutyryl-CoA mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13737", "l": "an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730902", "l": "Oligomerization of p-CARMA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696822", "l": "AKR1B15 reduces EST17b to E1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196773", "l": "COASY phosphorylates DP-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69776", "l": "(2E,6E)-farnesyl diphosphate => beta-ylangene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74053", "l": "D-threonine(in) + L-alanine(out) => D-threonine(out) + L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5615668", "l": "AKR1C3 reduces atRAL to atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018847", "l": "alpha-pinene lyase activity", "d": ["Catalysis of the reaction: alpha-pinene = limonene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23780", "l": "H2O + oxaloacetate + propanoyl-CoA = (2S,3S)-2-methylcitrate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.5", "l": "\"2-methylcitrate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672980", "l": "Dissociation of RAS:RAF complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34544", "l": "N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182594", "l": "Association of INK4 family proteins with CDK4/6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30265", "l": "2 H2O + 2 monodehydro-L-ascorbate radical => H2O2 + 2 L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55851", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75214", "l": "Cu(+)(out) <=> Cu(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33867", "l": "(S)-2-ureidoglycine + glyoxylate = glycine + N-carbamoyl-2-oxoglycine", "d": []}, {"i": "EC:2.6.1.112", "l": "\"(S)-ureidoglycine--glyoxylate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265894", "l": "BRIP1 (FANCJ) helicase functions in direct unwinding of DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651971", "l": "Defective SLC34A3 does not cotransport Pi, 2Na+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68760", "l": "3 (R)-3-phenyllactate + (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022C + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0005324", "l": "long-chain fatty acid transporter activity", "d": ["Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0047045", "l": "testosterone 17-beta-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35861", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877192", "l": "RUNX1 binds FOXP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109858", "l": "MAP2K2 binds MAPK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380949", "l": "AMPK is dephosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.52", "l": "\"beta-N-acetylhexosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21781", "l": "A + cyclohexanone => AH2 + cyclohex-2-enone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50124", "l": "NAD(+) + resolvin D1 = 8-oxoresolvin D1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209120", "l": "Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47247", "l": "(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444691", "l": "Prokineticin receptors bind prokineticin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14670", "l": "D-glyceraldehyde 3-phosphate + H2O + NADP(+) => (2R)-3-phosphoglycerate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008972", "l": "phosphomethylpyrimidine kinase activity", "d": ["Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012835", "l": "GDIs block activation of RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5220959", "l": "TDG excises 5-formylcytosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62667", "l": "(2'R)-atrovenetin + S-adenosyl-L-methionine <=> deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913360", "l": "GM-CSF receptor alpha subunit binds GM-CSF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201608", "l": "Caspase-mediated cleavage of alpha adducin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416516", "l": "GRK2 sequesters activated Gq (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862084", "l": "PILRA,PILRB bind CD99 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954082", "l": "E2F6 binds the PRC1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74492", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B => yaequinolone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75185", "l": "diphosphate + lydicene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48304", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944255", "l": "Association of procollagen type VII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000402", "l": "crossed form four-way junction DNA binding", "d": ["Binding to a DNA segment containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56642", "l": "(9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58957", "l": "a ribonucleotide in RNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64348", "l": "2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+) = deacetylpyripyropene E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623705", "l": "Defective SLC12A3 does not cotransport Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75034", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 9-hydroxy-octadecanoate <=> (9Z-octadecenoyl)-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42682", "l": "2 H2O + 2 hercynylselenocysteine => 2 hercynine + 2 L-selenocysteine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947499", "l": "Exchange of oxygen with sulfur in MoCo (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66345", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9716913", "l": "ESR1 binds ESR1 antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560794", "l": "Defective PAPSS2 does not transfer SO4(2-) group to ATP to form APS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69684", "l": "daidzein 7-O-beta-D-glucoside + H2O => beta-D-glucose + daidzein + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5082356", "l": "HSF1-mediated gene expression (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018814", "l": "RHOT1 hydrolyzes GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180709", "l": "Association of multimerized Rev with beta-importin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2248891", "l": "Active ARSA translocates to the lysosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42272", "l": "3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] = 5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418172", "l": "F2R binds ARRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41697", "l": "1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375395", "l": "C5a receptor binds C5a anaphylatoxin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59701", "l": "D-cellopentaono-1,5-lactone + H2O => D-cellopentaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36014", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.129", "l": "\"endo-alpha-sialidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24626", "l": "AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr) => ATP + L-threonine + tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003841", "l": "1-acylglycerol-3-phosphate O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004958", "l": "prostaglandin F receptor activity", "d": ["Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27880", "l": "3'-UMP + H(+) => 2',3'-cyclophospho-UMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009227", "l": "IL20 binds to IL22RA1:JAK1:IL20RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972978", "l": "POU5F1 (OCT4), SOX2, NANOG bind the ZIC3 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22098", "l": "a ribonucleoside 5'-diphosphate + RNA(n) => phosphate + RNA(n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51914", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388560", "l": "EDNRA,EDNRB bind EDNs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132074", "l": "Cleavage of surface-bound factor B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.892466024748572", "identifiers": [{"i": "GO:0051119", "l": "sugar transmembrane transporter activity", "d": ["Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35851", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19808", "l": "a purine D-ribonucleoside + phosphate <=> a purine nucleobase + alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710354", "l": "GSDME (1-270) binds cardiolipin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210430", "l": "Release of L-Glutamate at the synapse (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66026", "l": "[collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O => hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41626", "l": "H(+) + propanoyl-CoA + sulfite => 3-sulfinopropanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21411", "l": "H2O + L-phenylalanine + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863494", "l": "ASICs bind STOML3, (STOM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28316", "l": "baicalin + UDP => baicalein + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22771", "l": "4-nitrophenyl-3-ketovalidamine <=> 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32924", "l": "H2O + sn-glycero-3-phospho-(1'-sn-glycerol) => glycerol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38091", "l": "delta-tocotrienol + S-adenosyl-L-methionine = beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854981", "l": "SHC1 in the RET complex is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392870", "l": "Gs activation by prostacyclin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20958", "l": "AMP + diphosphate + phenylacetyl-CoA => 2-phenylacetate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62452", "l": "ATP + holo-[peptidyl-carrier protein] + L-glutamate = AMP + diphosphate + L-glutamyl-[peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.68", "l": "\"L-glutamate--[L-glutamyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607753", "l": "CARD9 oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0016308", "l": "1-phosphatidylinositol-4-phosphate 5-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75220", "l": "H2O + L-fucono-1,5-lactone => H(+) + L-fuconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63493", "l": "H(+) + menadione + NADPH => menadiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40701", "l": "1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34414", "l": "cannabigerolate + O2 <=> cannabidiolate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731924", "l": "EDNRA binds EDNs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71329", "l": "chloride(in) + L-threonine(in) + 2 Na(+)(in) => chloride(out) + L-threonine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0008474", "l": "palmitoyl-(protein) hydrolase activity", "d": ["Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21050", "l": "ADP + gamma-L-glutamyl-isopropylamide + H(+) + phosphate => ATP + isopropylamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15933", "l": "(S)-propane-1,2-diol + NAD(+) = (S)-lactaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380311", "l": "Recruitment of Plk1 to centrosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200646", "l": "Cytosolic folate export across the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24483", "l": "a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O <=> a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37582", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3785768", "l": "MRN complex binds DNA double strand breaks (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18278", "l": "a thiol + S-adenosyl-L-methionine => a methyl thioether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40643", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40471", "l": "(2S)-methylpentadecanoyl-CoA + O2 = 2-methyl-(2E)-pentadecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1470009", "l": "Phosphorylation of STATs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21107", "l": "AH2 + cholesterol + O2 <=> 25-hydroxycholesterol + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51286", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate => (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008700", "l": "4-hydroxy-2-oxoglutarate aldolase activity", "d": ["Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37630", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine <=> 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139909", "l": "Translocation of BMF to mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47401", "l": "3-oxo-(9Z-octadecenoyl)-CoA + CoA => (7Z)-hexadecenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044715", "l": "8-oxo-dGDP phosphatase activity", "d": ["Catalysis of the reaction 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420688", "l": "GABAB heterodimeric receptor binds GABA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32552", "l": "(2E)-geranyl diphosphate + H2O => (S)-alpha-terpineol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965446", "l": "WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21896", "l": "(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP = adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21187", "l": "a dolichyl phosphate + GDP-alpha-D-mannose <=> a dolichyl beta-D-mannosyl phosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66329", "l": "taurine(out) => taurine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56542", "l": "1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191636", "l": "Phosphorylation of Cx43 by c-src (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954117", "l": "E2F6:TFDP1 binds EPC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009384", "l": "N-acylmannosamine kinase activity", "d": ["Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004039", "l": "allophanate hydrolase activity", "d": ["Catalysis of the reaction: H2O + 3 H+ + urea-1-carboxylate = 2 CO2 + 2 NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784861", "l": "HSPG binds LPL dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75782", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoate + H2O <=> (10S)-hydroxy-(6Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41919", "l": "H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] <=> 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733960", "l": "Bile salts and acids dissociate from ALB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0001530", "l": "lipopolysaccharide binding", "d": ["Binding to a lipopolysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66054", "l": "H2O + kynurenate + L-tryptophan => indole-3-pyruvate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74169", "l": "formaldehyde + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] + sarcosine => H2O + N,N-dimethylglycine + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605595", "l": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381377", "l": "Expression of KLF5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48202", "l": "reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA => H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24564", "l": "a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733960", "l": "Bile salts and acids dissociate from ALB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190519", "l": "Internalization of gap junction plaques (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783483", "l": "tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849882", "l": "SALMs 1-4 bind reticulon 3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23252", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41924", "l": "(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607002", "l": "Activated protein C cleaves factor VIIIa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177922", "l": "EGFR dimerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53623", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (-)-spiroviolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40905", "l": "H(+) + hexadecanoate + sn-glycerol 3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58578", "l": "H(+) + NADPH + precondylocarpine acetate => dihydroprecondylocarpine acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65176", "l": "A + protoaustinoid A = AH2 + protoaustinoid B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12646", "l": "CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] => (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51640", "l": "(9Z,12Z)-octadecadienoate + O2 = (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49363", "l": "2',2'-dihydroxy-2-oxospirilloxanthin <=> 2,2'-dioxospirilloxanthin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159796", "l": "Furin cleaves pro-factor IX to factor IX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1362416", "l": "Frataxin binds iron (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24552", "l": "5alpha-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64447", "l": "L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0010484", "l": "histone H3 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12436", "l": "(E)-caffeoyl-CoA + putrescine = CoA + H(+) + N-caffeoylputrescine", "d": []}, {"i": "EC:2.3.1.138", "l": "\"putrescine N-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48274", "l": "2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74963", "l": "L-leucine(out) + L-ornithine(in) + Na(+)(out) = L-leucine(in) + L-ornithine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169421", "l": "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21619", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48601", "l": "[protein-PII]-uridylyl-L-tyrosine + H2O => [protein-PII]-L-tyrosine + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953013", "l": "E2F7 binds E2F8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44192", "l": "2-methylhexadecanoate + ATP + CoA = 2-methylhexadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391936", "l": "EP1 receptor can bind PGE2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62084", "l": "ADP + D-glucosamine = AMP + D-glucosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56206", "l": "3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26352", "l": "beta-L-galactose 1-phosphate + H2O <=> L-galactose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11823", "l": "diphthamide-[translation elongation factor 2] + NAD(+) <=> H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202328", "l": "Translocation of PKC theta to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034228", "l": "ethanolamine transmembrane transporter activity", "d": ["Enables the transfer of ethanolamine from one side of a membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine."]}, {"i": "RHEA:32747", "l": "ethanolamine(in) = ethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0070064", "l": "proline-rich region binding", "d": ["Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55118", "l": "(3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+) => 5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198731", "l": "ERK1/2 activates ELK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008048", "l": "calcium sensitive guanylate cyclase activator activity", "d": ["Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016005", "l": "phospholipase A2 activator activity", "d": ["Binds to and increases the activity of the enzyme phospholipase A2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44201", "l": "12-methyloctadecanoate + ATP + CoA => 12-methyloctadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174224", "l": "Dissociation of Cdc20 from APC/C complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32808", "l": "thiosulfate(in) => thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874198", "l": "CREB3L2 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12798", "l": "(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + scopolamine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41296", "l": "H2O + N-(hexanoyl)sphing-4-enine => hexanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032843", "l": "hydroperoxide reductase activity", "d": ["Catalysis of the reaction: 2 RSH + ROOH = RSSR + ROH + H2O. This reaction is the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106258", "l": "L-serine-phosphatidylcholine phosphatidyltransferase activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline."]}, {"i": "RHEA:45088", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418456", "l": "cGMP is degraded by PDEs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17812", "l": "Mg-protoporphyrin IX + S-adenosyl-L-methionine <=> Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140704", "l": "3',2'-cyclic GMP-AMP binding", "d": ["Binding to 3',2' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 2',5' linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17118", "l": "ATP + L-glutamate + methylamine => ADP + H(+) + N(5)-methyl-L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28081", "l": "2-hydroxyethylphosphonate + NAD(+) <=> H(+) + NADH + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392295", "l": "Gbeta:gamma recruits PI3K gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19953", "l": "a 2-oxocarboxylate + L-alanine = an L-alpha-amino acid + pyruvate", "d": []}, {"i": "EC:2.6.1.12", "l": "\"alanine--oxo-acid transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170978", "l": "p-FRS2:CRKL binds C3G (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199298", "l": "AKT phosphorylates CREB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17596", "l": "3-phenylpyruvate + L-glutamine <=> 2-oxoglutaramate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809254", "l": "MTMR8 binds MTMR9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2426569", "l": "Interaction of DAP12 and IREM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038191", "l": "neuropilin binding", "d": ["Binding to a member of the neuropilin family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033838", "l": "flavonol-3-O-glucoside glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050001", "l": "D-glutaminase activity", "d": ["Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20191", "l": "H(+) + NADH + uracil => 5,6-dihydrouracil + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48800", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34798", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O <=> alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27804", "l": "all-trans-decaprenyl diphosphate + 7 diphosphate => (2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27774", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59658", "l": "D-cellotriono-1,5-lactone + H2O2 => D-cellotriose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50659", "l": "3-(2-methylsulfanyl)ethylmalate <=> 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047252", "l": "beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase activity", "d": ["Catalysis of the reaction: (1->6)-alpha-D-mannosyloligosaccharide + beta-D-mannosylphosphodecaprenol = (1->6)-alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-oligosaccharide + decaprenol phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64867", "l": "ITP + oxaloacetate <=> CO2 + IDP + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043430", "l": "2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-decaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41103", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27957", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + presilphiperfolan-8beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033737", "l": "1-pyrroline dehydrogenase activity", "d": ["Catalysis of the reaction: 1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58873", "l": "24-methylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193653", "l": "NGF homodimer binds to p75NTR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25219", "l": "CoA + H(+) + N-acetylserotonin => acetyl-CoA + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72470", "l": "2 acetyl-CoA + 5 H(+) + 6 malonyl-CoA <=> 6 CO2 + 8 CoA + H2O + o-orsellinate depside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62052", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36009", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008841", "l": "dihydrofolate synthase activity", "d": ["Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70842", "l": "L-arginine(in) + L-histidine(out) + Na(+)(out) <=> L-arginine(out) + L-histidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.-", "l": "\"Aminopeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-217255", "l": "FMO1:FAD N-oxidises TAM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.25", "l": "\"L-arginine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018774", "l": "RHOBTB1 binds GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9688459", "l": "RIPK3 binds HSP90:CDC37 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68548", "l": "O2 + psoralen + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + xanthotoxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158849", "l": "Phenol can form a sulfate conjugate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388560", "l": "EDNRA,EDNRB bind EDNs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29293", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate => (25S)-3-oxocholest-4-en-26-oate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59725", "l": "D-maltoheptaono-1,5-lactone + H2O => D-maltoheptaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10905", "l": "[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A => AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34996", "l": "L-rhamnose(in) => L-rhamnose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62187", "l": "peregrinol diphosphate <=> diphosphate + labd-13(16),14-diene-9-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008812", "l": "choline dehydrogenase activity", "d": ["Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21165", "l": "a carboxylic ester + H2O => a carboxylate + an alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661217", "l": "MT1A binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10126", "l": "benzyl acetate + H2O + NADP(+) => H(+) + NADPH + O2 + phenylacetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18323", "l": "4-methyl-2-oxopentanoate + L-glutamate => 2-oxoglutarate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14359", "l": "ADP + FMN + H(+) => ATP + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.211", "l": "\"endo-(1->3)-fucoidanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030290", "l": "sphingolipid activator protein activity", "d": ["Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase."]}, {"i": "REACT:R-HSA-1605717", "l": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46580", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 = 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033970", "l": "N-malonylurea hydrolase activity", "d": ["Catalysis of the reaction: 3-oxo-3-ureidopropanoate + H2O = H+ + malonate + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68782", "l": "alpha-humulene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26022", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O <=> beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236970", "l": "Proteasomal clevage of exogenous antigen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665998", "l": "MKL1 binds SRF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694421", "l": "PP6 dephosphorylates SEC24 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54591", "l": "S-adenosyl-L-methionine + uridine in 25S rRNA <=> H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981728", "l": "Factor H binds to membrane-associated C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209792", "l": "N-acetylation of serotonin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21659", "l": "CDP-alpha-D-paratose <=> CDP-3,6-dideoxy-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37427", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14457", "l": "glyoxylate + H2O + pentanoyl-CoA = 3-propylmalate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.12", "l": "\"3-propylmalate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37668", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350578", "l": "NQO1 interaction with ODC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709406", "l": "CO binds to Cytochrome c oxidase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696356", "l": "OSCAR binds collagen and SP-D (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140844", "l": "NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of ADP-ribose groups to the glutamate-2 residue of the N-terminal tail of histone H2B (or an equivalent residue)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381644", "l": "ER calcium channels open in response to activated PKA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60766", "l": "cinerin II + CoA => (1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65869", "l": "Delta(1)-dihydrotestosterone + H2O => 1,17beta-dihydroxyandrostan-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68656", "l": "7-oxocholesterol + H(+) + NADPH = 7beta-hydroxycholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50498", "l": "CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein] => acetyl-CoA + N-terminal glycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63144", "l": "H2O + N-(15Z-tetracosenoyl)-ethanolamine = (15Z)-tetracosenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53726", "l": "ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate => ATP + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033815", "l": "biphenyl synthase activity", "d": ["Catalysis of the reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13926", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine => holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34238", "l": "4-nitro-6-oxohepta-2,4-dienedioate <=> 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483170", "l": "PS transports from the ER membrane to the IM membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46280", "l": "an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.18", "l": "\"sphingolipid 8-(E)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70922", "l": "chloride(out) + dopamine(out) + Na(+)(out) <=> chloride(in) + dopamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59198", "l": "AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] => holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61988", "l": "cytidine(72) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433395", "l": "Dimerization of sSCF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57910", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP => ATP + L-glutamyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909732", "l": "Phosphorylation of STAT2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14375", "l": "(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48475", "l": "ganglioside GT1a + H2O <=> ganglioside GD1a + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55541", "l": "40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] => 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047524", "l": "16-hydroxysteroid epimerase activity", "d": ["Catalysis of the reaction: 16-alpha-hydroxysteroid = 16-beta-hydroxysteroid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035374", "l": "chondroitin sulfate binding", "d": ["Binding to chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944215", "l": "Association of procollagen type XX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001877", "l": "lipoarabinomannan immune receptor activity", "d": ["Combining with lipoarabinomannan and transmitting the signal to initiate an innate immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30058", "l": "L-allo-threonine + NADP(+) <=> (2S)-2-amino-3-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030598", "l": "rRNA N-glycosylase activity", "d": ["Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20826", "l": "ADP + AMP + H(+) => adenosine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37185", "l": "1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18371", "l": "dihydroxyacetone phosphate + H2O2 => O2 + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33046", "l": "(1R,4R)-camphor + H(+) + NADPH + O2 <=> (+)-6-exo-hydroxycamphor + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163310", "l": "TFAM binds to mitochondrial promoters (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41846", "l": "(2E)-octenoyl-[ACP] + H2O => (3R)-hydroxyoctanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27790", "l": "2-all-trans-octaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38593", "l": "chloroorienticin B + dTDP + H(+) => devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37787", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31433", "l": "(-)-beta-santalene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43816", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030596", "l": "alpha-L-rhamnosidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001874", "l": "(1->3)-beta-D-glucan immune receptor activity", "d": ["Combining with (1->3)-beta-D-glucans to initiate an innate immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202500", "l": "Activation of IKK complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31728", "l": "FADH2 + O2 + styrene => (2S)-2-phenyloxirane + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67402", "l": "allo-aromadendrene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0002054", "l": "nucleobase binding", "d": ["Binding to a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35056", "l": "3,6-dichlorocatechol + O2 => (2E,4E)-2,5-dichloromuconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390886", "l": "HRH4 binds Hist (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35814", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol <=> (-)-medicarpin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37921", "l": "(8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.107", "l": "\"peptidase Do\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48847", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11111", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate <=> n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021068", "l": "PalmS-ESRs bind CAVs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72697", "l": "Start codon recognition (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11609", "l": "[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58644", "l": "N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72631", "l": "Formation of the cap-binding eIF4F complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43071", "l": "beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54127", "l": "coelenterazine h dioxetanone <=> CO2 + excited coelenteramide h monoanion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44145", "l": "acetyl-CoA + L-methionine => CoA + H(+) + N(alpha)-acetyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48249", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) => CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373705", "l": "Caspase cleavage of DCC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483089", "l": "PE is converted to PS by PTDSS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374919", "l": "Noradrenaline clearance from the synaptic cleft (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8856951", "l": "PP2A demethylation by PPME1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50417", "l": "L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] => H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37132", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9734713", "l": "ORC6 translocates to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0043395", "l": "heparan sulfate proteoglycan binding", "d": ["Binding to a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14932", "l": "NAD(+) + testosterone <=> androst-4-ene-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140537", "l": "transcription regulator activator activity", "d": ["A molecular function regulator that increases the activity of a transcription regulator via direct binding and/or post-translational modification."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50681", "l": "H2O + N-terminal L-glutaminyl-[protein] => N-terminal L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052655", "l": "L-valine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.093101469280398", "identifiers": [{"i": "GO:0052745", "l": "inositol phosphate phosphatase activity", "d": ["Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011224", "l": "ROBO3.1 binds DCC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70644", "l": "D-proline(out) + H(+)(out) => D-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12464", "l": "myo-inositol + UDP-alpha-D-galactose = alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.123", "l": "\"inositol 3-alpha-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19982", "l": "NADP(+) + S-(hydroxymethyl)glutathione => H(+) + NADPH + S-formylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781840", "l": "ERCC6 binds stalled RNA Pol II (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62363", "l": "FMN-N(5)-peroxide + uracil <=> (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53881", "l": "ADP-alpha-D-glucose + D-glucose 6-phosphate => ADP + alpha,alpha-trehalose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0120017", "l": "ceramide transfer activity", "d": ["Removes a ceramide from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62708", "l": "(indol-3-yl)butanoate + UDP-alpha-D-glucose = 4-(indol-3-yl)butanoyl-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18118", "l": "L-tyrosine + O2 => H2O + L-dopaquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693198", "l": "RHOD binds effectors at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24050", "l": "alpha-D-glucose 1-phosphate + D-fructose => phosphate + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450474", "l": "MK2 phosphorylates BRF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74277", "l": "a 2-acyl-sn-glycero-3-phosphocholine + a hepta-acyl lipid A => a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13205", "l": "a monosaccharide 1-phosphate + H(+) + UTP = a UDP-monosaccharide + diphosphate", "d": []}, {"i": "EC:2.7.7.64", "l": "\"UTP-monosaccharide-1-phosphate uridylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102677", "l": "campesterol,NADPH:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: H+ + campesterol + O2 + NADPH <=> (22S)-22-hydroxycampesterol + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65197", "l": "H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine => H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109860", "l": "MAP2K1 phosphorylates MAPK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9645598", "l": "RRAGC,D hydrolyzes GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62483", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O <=> 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25321", "l": "N-methylethanolamine phosphate + S-adenosyl-L-methionine = H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13992", "l": "alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose <=> alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684336", "l": "nsp1-4 cleaves itself (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008577", "l": "IL37:IL18R1 binds SIGIRR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67999", "l": "(Z)-1,2-dichloroethene + AH2 <=> A + chloride + chloroethene + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418172", "l": "F2R binds ARRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008784", "l": "alanine racemase activity", "d": ["Catalysis of the reaction: L-alanine = D-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73702", "l": "ADP(in) + dATP(out) <=> ADP(out) + dATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380229", "l": "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45386", "l": "(9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine => H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.2.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49879", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71225", "l": "chloride(in) + 2 Na(+)(in) + taurine(in) => chloride(out) + 2 Na(+)(out) + taurine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168987", "l": "DLL4 binds NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.36", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22169", "l": "UDP-alpha-D-glucose => UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33967", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O = 3-maleylpyruvate + H(+)", "d": []}, {"i": "EC:3.1.1.91", "l": "\"2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44479", "l": "1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1-O-alkyl-2-acetyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47360", "l": "decanoate ester + H2O = an aliphatic alcohol + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382054", "l": "PDGF binds to extracellular matrix proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013021", "l": "GDIs block activation of RHOB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56132", "l": "(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA = a thymidine dimer in DNA", "d": []}, {"i": "EC:4.1.99.14", "l": "\"spore photoproduct lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33633", "l": "AMP + diphosphate + octanoyl-CoA => ATP + CoA + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57174", "l": "2-oxoglutarate + H(+) + NADH => (S)-2-hydroxyglutarate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75807", "l": "Na(+)(out) + propanoate(out) = Na(+)(in) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74795", "l": "N-methyl-(R)-salsolinol(in) = N-methyl-(R)-salsolinol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420117", "l": "VEGFR2 autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47212", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48909", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362522", "l": "ALDHs oxidise atRAL to atRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57671", "l": "alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0032576", "l": "O-linoleoyltransferase activity", "d": ["Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9671145", "l": "DKC1 binds SHQ1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954185", "l": "ERBB4s80:TAB2:NCOR1 complex binds GFAP gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46649", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA => androst-4-ene-3,17-dione + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021609", "l": "ESR-associated SRC autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71363", "l": "17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out) = 17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211247", "l": "Cleavage of DNA by DFF40 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022941", "l": "MECP2 binds GAD2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51855", "l": "(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168337", "l": "Docking and transport of the RNP:Karyopherin complex through the nuclear pore (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24049", "l": "phosphate + sucrose => alpha-D-glucose 1-phosphate + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60218", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57466", "l": "1-O-[(E)-caffeoyl]-beta-D-glucose + UDP => (E)-caffeate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68372", "l": "L-asparagine + pyruvate = 2-oxosuccinamate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53282", "l": "D-erythrulose => D-threose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21750", "l": "H(+) + methylglyoxal + NADPH => (S)-lactaldehyde + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54227", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphocholine <=> 2-(prostaglandin E2)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61589", "l": "amicoumacin A + ATP => ADP + amicoumacin A 2-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68120", "l": "a 1,2-diacylglycerol + a fatty acyl-CoA = a triacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350651", "l": "Caspase-mediated cleavage of MASK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61968", "l": "a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47236", "l": "eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43095", "l": "S-adenosyl-L-methionine + uridine(2479) in 23S rRNA <=> 2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69666", "l": "H2O + luteolin 7-O-beta-D-glucoside <=> beta-D-glucose + luteolin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28427", "l": "D-allulose 6-phosphate => keto-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40263", "l": "(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) = 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.41", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033556", "l": "dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity", "d": ["Catalysis of the addition of a glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(7)GlcNAc(2)-PP-Dol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29024", "l": "H(+)(in) + L-fucose(in) => H(+)(out) + L-fucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63578", "l": "ecdysone + phosphate => ecdysone 22-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445704", "l": "Calcium Binds Caldesmon (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35809", "l": "2,5-dioxopentanoate + H2O => 2-dehydro-3-deoxy-D-arabinonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73224", "l": "(3S)-citramalate(in) + sulfate(out) => (3S)-citramalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042169", "l": "SH2 domain binding", "d": ["Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29711", "l": "cadaverine(in) + H(+)(in) = cadaverine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159771", "l": "Furin cleaves pro-protein C to protein C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11541", "l": "an N-acyl-D-mannosamine + NAD(+) => an N-acyl-D-mannosaminolactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865280", "l": "TFAP2C homodimer binds the CDKN1A (p21) gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009371", "l": "Binding of AP1 transcriptional activator complexes to CCND1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351936", "l": "Caspase-mediated cleavage of claspin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16351", "l": "A + chlorite + H2O => AH2 + chlorate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59857", "l": "Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium => methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37837", "l": "epsilon-rhodomycinone + H2O + NADP(+) => aklavinone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679266", "l": "Beclin-1 complex translocates to the ER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37839", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33497", "l": "3-heptaprenyl-sn-glycero-1-phosphate + diphosphate => all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71332", "l": "chloride(out) + L-phenylalanine(out) + 2 Na(+)(out) => chloride(in) + L-phenylalanine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047124", "l": "L-erythro-3,5-diaminohexanoate dehydrogenase activity", "d": ["Catalysis of the reaction: (3S,5S)-3,5-diaminohexanoate + H2O + NAD+ = (S)-5-amino-3-oxo-hexanoate + H+ + NADH + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102427", "l": "allocryptopine 6-hydroxylase activity", "d": ["Catalysis of the reaction: allocryptopine + NADPH + O2 + H+ <=> 6-hydroxy-allocryptopine + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73803", "l": "dimethylallyl diphosphate + neoechinulin B = diphosphate + isoechinulin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36782", "l": "2-oxoglutarate + GDP-alpha-D-perosamine <=> GDP-4-dehydro-alpha-D-rhamnose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173705", "l": "C5b binds C6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038386", "l": "Dimerization of FGFR3 t(4;14) translocation mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011748", "l": "IL9R binds JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112392", "l": "Resumption of elongation after recovery from pausing (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47294", "l": "4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76083", "l": "(11R)-carlactone + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-19-hydroxycarlactone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15691", "l": "CO2 + propane-1,3-diamine => H(+) + L-2,4-diaminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018698", "l": "vinyl chloride reductive dehalogenase activity", "d": ["Catalysis of the reaction: vinyl chloride + 2 H+ + 2 e- = HCl + ethene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909720", "l": "IFN alpha/beta binds to IFNAR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36865", "l": "(9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O => (9Z)-octadecenoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445714", "l": "Aquaporin-3 passively transports water out of cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683964", "l": "ATM phosphorylates EYA1-4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58271", "l": "[protein]-C-terminal glycine + NAD(+) <=> [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58805", "l": "5'-pApG-3' + H2O => 5'-ApG-3' + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36165", "l": "ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685156", "l": "ATR phosphorylates RPA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729300", "l": "Unknown kinase phosphorylates nucleoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21630", "l": "acetate + androst-4-ene-3,17-dione + H2O + NADP(+) => 17alpha-hydroxyprogesterone + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034526", "l": "2-methylnaphthalene hydroxylase activity", "d": ["Catalysis of the reaction: 2-methylnaphthalene + NADH + O2 + H+ = 2-hydroxymethylnaphthalene + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12171", "l": "allyl alcohol + NADP(+) <=> acrolein + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54495", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine <=> 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.96", "l": "\"diiodophenylpyruvate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75857", "l": "9-cis-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 9-cis-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047338", "l": "UTP:xylose-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-xylose 1-phosphate + UTP = UDP-D-xylose + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706293", "l": "Active FLT3 binds to CBL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59830", "l": "inosine + L-homocysteine => H2O + S-inosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45793", "l": "2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 => [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47975", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761818", "l": "NFE2L2 binds the GSR gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23025", "l": "[(1->4)-beta-D-glucosyl](n) + phosphate => [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40103", "l": "H2O + propanoyl-CoA = CoA + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73866", "l": "dopamine(out) <=> dopamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683593", "l": "ATG7:ATG3:LC3 dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.8", "l": "\"4-hydroxy-tetrahydrodipicolinate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72962", "l": "(R)-3-hydroxybutanoate(out) + 2 Na(+)(out) <=> (R)-3-hydroxybutanoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62095", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5246478", "l": "APOM binds retinoids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102724", "l": "UDP-glucose:curcumin monoglucoside glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + curcumin monoglucoside = H+ + curcumin diglucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75926", "l": "(S)-4-aminopentanoate + H2O + NAD(+) <=> 4-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14713", "l": "A + keto-L-sorbose = 5-dehydro-D-fructose + AH2", "d": []}, {"i": "EC:1.1.99.12", "l": "\"sorbose dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693575", "l": "DNA-PKcs autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58901", "l": "1-carboxybiuret + H2O => NH4(+) + urea-1,3-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29594", "l": "2-hydroxyethane-1-sulfonate + NADP(+) <=> H(+) + NADPH + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676229", "l": "WIPIs bind PI3P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4411383", "l": "NLK phosphorylates TCF/LEF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57603", "l": "a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660665", "l": "Caspase-8 binds MALT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29916", "l": "L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) + UDP-alpha-D-glucose => alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177942", "l": "EGFR binds EGF ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018778", "l": "DL-2 haloacid dehalogenase activity", "d": ["Catalysis of the reaction: trichloroacetate + 2 H2O = 3 H+ + 3 Cl- + oxalate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10782", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) + NADH => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55187", "l": "2-oxoglutarate + 3-methylundecanoyl-CoA + O2 <=> 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72178", "l": "5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) <=> 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847537", "l": "RAB43:GTP binds USP8NL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0140707", "l": "chromatin-nuclear membrane anchor activity", "d": ["Binding to chromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization, or to enable equal segregation of the nuclear membrane during mitosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11598", "l": "CO2 + UMP => H(+) + orotidine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11673", "l": "chorismate + L-glutamine => 4-amino-4-deoxychorismate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186819", "l": "SH2 domain of Src binds to the active receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70293", "l": "H2O + quinolin-4-ol => 3-(2-aminophenyl)-3-oxopropanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28964", "l": "H(+)(out) + L-proline(out) => H(+)(in) + L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.780700721499244", "identifiers": [{"i": "GO:0005126", "l": "cytokine receptor binding", "d": ["Binding to a cytokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801195", "l": "STEAP3 binds BNIP3L (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-919404", "l": "Phosphorylated STAT5 is released (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10884", "l": "(24R,24(1)R)-fucosterol epoxide = acetaldehyde + desmosterol", "d": []}, {"i": "EC:4.1.2.33", "l": "\"fucosterol-epoxide lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22046", "l": "ADP + 2 H(+)(out) + K(+)(in) + phosphate => ATP + H(+)(in) + H2O + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72663", "l": "De novo formation of eIF2:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090686", "l": "glycine betaine-activated nonselective monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a monoatomic cation by a channel that opens when glycine betaine has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018753", "l": "cyanuric acid amidohydrolase activity", "d": ["Catalysis of the reaction: cyanuric acid + H2O = biuret + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62579", "l": "ATP + H2O + L-cystine(out) <=> ADP + H(+) + L-cystine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60430", "l": "(indol-3-yl)acetate + L-aspartate => (indol-3-yl)acetyl-L-aspartate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70366", "l": "cyanurate + H2O <=> 1-carboxybiuret + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58591", "l": "dihydroprecondylocarpine acetate + NADPH <=> (+)-vincadifformine + acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71995", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = diphosphate + preaspterpenacid acid I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139920", "l": "Translocation of tBID to mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690701", "l": "SHP1 binds p-CD22 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34369", "l": "acrylate + NH4(+) => acrylamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201717", "l": "CSNK2-mediated phosphorylation of DVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604763", "l": "Autocatalytic activation of MMP7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67575", "l": "3'-phosphoadenylyl sulfate + alpha-muricholate <=> adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429767", "l": "Passive I- efflux mediated by SMCT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32822", "l": "chromate(in) <=> chromate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14403", "l": "chlordecone + H(+) + NADPH => chlordecone alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17813", "l": "D-altronate + NAD(+) = H(+) + keto-D-tagaturonate + NADH", "d": []}, {"i": "EC:1.1.1.58", "l": "\"tagaturonate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15288", "l": "AMP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21233", "l": "L-histidine => NH4(+) + trans-urocanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63780", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003681", "l": "bent DNA binding", "d": ["Binding to DNA in a bent conformation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23043", "l": "2-oxobutanoate + acetyl-CoA + H2O <=> (R)-2-ethylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38716", "l": "ATP + choline(out) + H2O => ADP + choline(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40553", "l": "H(+) + phylloquinol + S-adenosyl-L-homocysteine => demethylphylloquinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36270", "l": "caffeine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809764", "l": "SBF1 binds MTMR2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106242", "l": "kolavenyl diphosphate synthase activity", "d": ["Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-kolavenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63733", "l": "UDP-alpha-D-glucuronate + zolasartan => UDP + zolarsartan O-beta-D-glucuronoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65641", "l": "(4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30418", "l": "H(+) + 2 NADPH + O2 + octadecanal <=> formate + H2O + heptadecane + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17676", "l": "quercetin + S-adenosyl-L-methionine <=> 3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2430552", "l": "p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38442", "l": "(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46818", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62499", "l": "ATP + H(+) + L-arginine <=> diphosphate + L-arginyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11523", "l": "(-)-menthol + UDP-alpha-D-glucose <=> (-)-menthyl beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47777", "l": "guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167077", "l": "Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43210", "l": "5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine => 5-(carboxymethyl)uridine(34) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183055", "l": "Binding of CBL to EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1449687", "l": "Corticosteroids bind to CBG in blood (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791016", "l": "SFTPB binds itself (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43017", "l": "an S-alkyl-L-cysteine => 2-aminoprop-2-enoate + an alkyl thiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944257", "l": "Association of procollagen type XXIV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45094", "l": "octanoate + sphing-4-enine => H2O + N-octanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67167", "l": "bromide + FADH2 + melleolide F + O2 <=> 6'-bromomelleolide F + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24160", "l": "D-galactose + O2 = D-galacto-hexodialdose + H2O2", "d": []}, {"i": "EC:1.1.3.9", "l": "\"galactose oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67632", "l": "a plastoquinone + 6 H(+)(in) + 2 reduced [2Fe-2S]-[ferredoxin] = a plastoquinol + 4 H(+)(out) + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:7.1.1.10", "l": "\"ferredoxin--quinone oxidoreductase (H(+)-translocating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49947", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate <=> (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71274", "l": "H(+)(in) + thiamine(out) <=> H(+)(out) + thiamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50747", "l": "2 glyphosate + O2 <=> 2 aminomethylphosphonate + 2 glyoxylate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63343", "l": "ATP + L-amino acyl-L-seryl-[protein] <=> (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65663", "l": "A + calciol + H2O <=> AH2 + calcidiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73794", "l": "dimethylallyl diphosphate + neoechinulin A <=> diphosphate + variecolorin G", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64721", "l": "H(+)(out) + pyruvate(out) => H(+)(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48081", "l": "abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase] => ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30060", "l": "(S)-dihydroorotate + fumarate => orotate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74611", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-glucosamine(out) = UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-glucosamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624668", "l": "CEBPA binds CDKN1A (p21) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72340", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + guaiacol + H(+) => catechol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14694", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => a dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647980", "l": "mature RAS proteins translocate to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166726", "l": "Activation of MASPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045152", "l": "antisigma factor binding", "d": ["Binding to an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18674", "l": "ATP + L-seryl-[receptor-protein] => ADP + H(+) + O-phospho-L-seryl-[receptor-protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103075", "l": "indole-3-pyruvate monooxygenase activity", "d": ["Catalysis of the reaction: 3-(indol-3-yl)pyruvate + NADPH + O2 + H+ <=> indole-3-acetate + carbon dioxide + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112396", "l": "Separation of elongating transcript from template (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59031", "l": "(Z)-24-ethylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2129353", "l": "Tropoelastin associates with microfibrils (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.73", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5444516", "l": "Formation of MSH2:MSH6 Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353300", "l": "MGMT mediated DNA Damage Reversal (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617179", "l": "PRKACA phosphorylates TNNI3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869683", "l": "oxPL binds LBP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848829", "l": "CBL autoubiquitinates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849428", "l": "PTPN1 binds PTK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209921", "l": "Monoiodinated tyrosine can be deiodinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63407", "l": "3,6-dichloropyridine-2,5-diol + FADH2 + O2 <=> 6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12405", "l": "D-glucose + UDP-alpha-D-galactose => H(+) + lactose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74997", "l": "epierythrostominol(out) => epierythrostominol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004995", "l": "tachykinin receptor activity", "d": ["Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31556", "l": "(5S)-5-amino-3-oxohexanoate + acetyl-CoA => (3S)-3-aminobutanoyl-CoA + acetoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69267", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate <=> an isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102821", "l": "bixin methyltransferase activity", "d": ["Catalysis of the reaction: bixin + S-adenosyl-L-methionine <=> bixin dimethyl ester + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29585", "l": "guanosine(out) + H(+)(in) => guanosine(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75335", "l": "bromide(in) + chloride(out) = bromide(out) + chloride(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33486", "l": "an acyl-CoA + ergosterol <=> CoA + ergosteryl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202722", "l": "CD48 binds CD244 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44728", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71378", "l": "2 Na(+)(out) + testosterone 17-sulfate(out) <=> 2 Na(+)(in) + testosterone 17-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35979", "l": "dimethylallyl diphosphate + verruculogen = diphosphate + fumitremorgin A", "d": []}, {"i": "EC:2.5.1.107", "l": "\"verruculogen prenyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70851", "l": "H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out) = H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865244", "l": "TFAP2A homodimer binds CDKN1A (p21) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203979", "l": "Coat Assembly (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74715", "l": "Autophosphorylation of insulin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204850", "l": "Interaction of Tie2 and Dok-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5221061", "l": "TDG excises 5-carboxylcytosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43492", "l": "7(1)-hydroxychlorophyll a + NADP(+) = chlorophyll b + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59533", "l": "(S)-reticuline + S-adenosyl-L-methionine => (S)-codamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47070", "l": "4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O => 4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3857336", "l": "CEBPB homodimerization (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24108", "l": "H2O + N-methyl-2-oxoglutaramate = 2-oxoglutarate + methylamine", "d": []}, {"i": "EC:3.5.1.36", "l": "\"N-methyl-2-oxoglutaramate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33098", "l": "chorismate + inosine + phosphoenolpyruvate <=> futalosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376119", "l": "Interaction of Bnip-2 with Cdc42 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48772", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a = 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13612", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380586", "l": "loading of Serotonin in synaptic vesicles (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71487", "l": "H2O + Leu-enkephalin = L-phenylalanyl-L-leucine + L-tyrosylglycylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603801", "l": "PEX19 binds PEX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16643", "l": "a long-chain fatty acid + ethanol + H(+) => a long-chain fatty acyl ethyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10851", "l": "an [alpha-factor](in) + ATP + H2O <=> ADP + an [alpha-factor](out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.39", "l": "\"chymase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202472", "l": "Translocation of TRAF6 to CBM complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161506", "l": "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27408", "l": "a ubiquinone + H2O + pyruvate <=> a ubiquinol + acetate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712086", "l": "ALK fusions phosphorylate PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433395", "l": "Dimerization of sSCF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851988", "l": "BTN2A2 binds T cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22642", "l": "3-oxosphinganine + H(+) + NADPH => NADP(+) + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176175", "l": "Stalling of DNA replication fork and RPA binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798749", "l": "Exocytosis of specific granule lumen proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018746", "l": "RHOQ binds effectors at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1170539", "l": "Prolactin receptor is internalized (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25827", "l": "H2O + O2 + spermine <=> H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73718", "l": "UBF-1 Binds rDNA Promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785181", "l": "LMF1,2 bind LIPC dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043999", "l": "histone H2AK5 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 5) = CoA + histone H2A N6-acetyl-L-lysine (position 5)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67983", "l": "beta-zeacarotene <=> 7,8-dihydro-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36525", "l": "(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693609", "l": "ATM phosphorylates TP53 at S15 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34821", "l": "curcumin + H(+) + NADPH => dihydrocurcumin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "58.010551085654427", "identifiers": [{"i": "GO:0016614", "l": "oxidoreductase activity, acting on CH-OH group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45490", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180003", "l": "S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity", "d": ["Catalysis of the reaction: S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) = S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out)."]}, {"i": "RHEA:75479", "l": "S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) = S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61883", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43240", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40082", "l": "docosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635853", "l": "Hh-dependent expression of GLI1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22352", "l": "H(+) + L-lysine = cadaverine + CO2", "d": []}, {"i": "EC:4.1.1.18", "l": "\"lysine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67650", "l": "2'-deoxyadenosine + H(+) + triphosphate => dATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36697", "l": "desmethyldescarbamoylnovobiocin + dTDP + H(+) => dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25928", "l": "3-methylquinoline + A + H2O = 3-methylquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63103", "l": "H(+) + ilicicolin C + NADPH + O2 <=> ascochlorin + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58595", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5607746", "l": "PKC-delta is activated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57091", "l": "an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13905", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.206", "l": "\"lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.25", "l": "\"beta-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651685", "l": "Defective SLC34A1 does not cotransport Pi, 3Na+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32063", "l": "8-oxo-dGDP + H2O = 8-oxo-dGMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296233", "l": "T2Rs bind bitter-tasting compounds (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61493", "l": "a sphingoid base + an ultra-long-chain fatty acyl-CoA => an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61333", "l": "ATP + H2O + indoxyl sulfate(in) => ADP + H(+) + indoxyl sulfate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030944", "l": "DDEL sequence binding", "d": ["Binding to a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65169", "l": "AH2 + O2 + preaustinoid A => A + H2O + preaustinoid A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1008200", "l": "NFE2 binds the beta globin locus control region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.41", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32001", "l": "bicyclogermacrene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70277", "l": "D-galactose + sucrose => H2O + raffinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38952", "l": "ATP + H2O + sphing-4-enine 1-phosphate(in) => ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209245", "l": "Tyrosine kinase Hopscotch (HOP) binds to the transmembrane cytokine receptor Domeless (DOME) to form the HOP:DOME complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25349", "l": "D-tyrosine + tRNA(Tyr) => D-tyrosyl-tRNA(Tyr) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5618107", "l": "ATP binding to HSP90 triggers conformation change (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852716", "l": "Thrombin, ELANE cleave C5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35988", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654651", "l": "Activated FGFR4 binds FRS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170964", "l": "FRS2 binds to active TrkA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15955", "l": "ADP + 2 H(+) + N(4)-phosphoagmatine => agmatine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27650", "l": "GTP + uridine = GDP + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0016922", "l": "nuclear receptor binding", "d": ["Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41454", "l": "3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+) => 5-methyl-1-naphthoate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29516", "l": "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56649", "l": "3-oxochol-4-en-24-oyl-CoA + NAD(+) => 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30619", "l": "2 A + all-trans-zeta-carotene = 2 AH2 + all-trans-lycopene", "d": []}, {"i": "EC:1.3.99.26", "l": "\"all-trans-zeta-carotene desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64698", "l": "benzaldehyde + H(+) + NADH => benzyl alcohol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30934", "l": "L-cysteine + O-acetyl-L-homoserine <=> acetate + H(+) + L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709360", "l": "H2O2 reduces MetHb (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16686", "l": "di-trans,poly-cis-dolichol + hexadecanoyl-CoA => a dolichyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12502", "l": "3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH => (3R)-1,4-thiomorpholine-3-carboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63996", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351207", "l": "Spermine  => N-acetylated spermine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29602", "l": "monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682826", "l": "LGI1 binds ADAM11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203553", "l": "eNOS binds NOSIP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-984733", "l": "Kinesin-3 is a dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052810", "l": "1-phosphatidylinositol-5-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350901", "l": "Iodide is organified (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52482", "l": "(3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6795473", "l": "PDPK1 phosphorylates SGK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73062", "l": "Ca(2+)(in) + Mn(2+)(out) <=> Ca(2+)(out) + Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26115", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + epi-cedrol", "d": []}, {"i": "EC:4.2.3.39", "l": "\"epi-cedrol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55955", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose <=> a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41397", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021919", "l": "MECP2:CREB1 binds SST gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10166", "l": "H2O + phosphoenolpyruvate => (2R)-2-phosphoglycerate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034946", "l": "3-isopropylbut-3-enoyl-CoA thioesterase activity", "d": ["Catalysis of the reaction: 3-isopropylbut-3-enoyl-CoA + H2O = 3-isopropylbut-3-enoic acid + CoASH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68413", "l": "H2O + L-glutamate 5-semialdehyde + NADP(+) => 2 H(+) + L-glutamate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52257", "l": "a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61835", "l": "sitosterol + UDP-alpha-D-glucose <=> H(+) + sitosteryl 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.59", "l": "\"glucan endo-1,3-alpha-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55015", "l": "(1S,4R)-1-hydroxylimonen-2-one + NADPH + O2 <=> (3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33310", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] <=> (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12274", "l": "CO2 + dopamine => H(+) + L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57613", "l": "20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH => 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381537", "l": "PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791114", "l": "Expression of FKBP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388900", "l": "Neurotensin receptors can bind neurotensins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854408", "l": "APOBR dimer binds VLDLs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56135", "l": "(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA <=> a thymidine dimer in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102184", "l": "cycloartenol 4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: cycloartenol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60703", "l": "a 1-acyl-sn-glycero-3-phosphocholine <=> a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11275", "l": "a (2R)-2-hydroxycarboxylate + a quinone <=> a 2-oxocarboxylate + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47834", "l": "ganglioside GM1 + N-acetylneuraminate => ganglioside GD1a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53361", "l": "5,6-dihydrouridine(47) in tRNA + NADP(+) => H(+) + NADPH + uridine(47) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62692", "l": "2 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + O2 = 2 H(+) + 2 H2O + 2 tellimagrandin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2250301", "l": "Formation of lysyl-pyrrole cross-links (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19772", "l": "phaseollidin hydrate <=> H2O + phaseollidin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55240", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15400", "l": "dichloromethane + H2O <=> 2 chloride + formaldehyde + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615604", "l": "Defective POMT1 does not transfer Man from Dol-P-Man to DAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64230", "l": "1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654573", "l": "Activated FGFR1 binds SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54524", "l": "acetoacetate + H(+) + methylglyoxal = 3-hydroxyhexane-2,5-dione + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60079", "l": "4beta-hydroxymethyl-4alpha-methylzymosterol + H(+) + NADH + O2 <=> 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17154", "l": "CDP-D-glucose => CDP-4-dehydro-6-deoxy-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61895", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH <=> a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57895", "l": "a quinone + 5 H(+)(in) + NADPH <=> a quinol + 4 H(+)(out) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141316", "l": "TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357472", "l": "PAK1-3 autophosphorylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73735", "l": "O2 + trans-resveratrol = 3,5-dihydroxybenzaldehyde + 4-hydroxybenzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27590", "l": "(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.44", "l": "\"pantoate--beta-alanine ligase (ADP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10817", "l": "H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside => L-fucose + methyl beta-D-galactoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35755", "l": "NAD(+) + UDP-alpha-D-glucose = H(+) + NADH + UDP-3-oxo-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49927", "l": "(R)-carnitine(out) + O-acyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-acyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58605", "l": "FAD + 2 H(+) + NADH + O2 => FADH2-C4alpha-hydroperoxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682009", "l": "ZCRB1 binds 5'UTR of SARS-CoV-1 genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047739", "l": "cephalosporin-C deacetylase activity", "d": ["Catalysis of the reaction: cephalosporin C + H2O = acetate + deacetylcephalosporin C + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33929", "l": "2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde => 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13783", "l": "a 2-oxocarboxylate + H2O2 + NH4(+) => an L-alpha-amino acid + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981622", "l": "Myoglobin:oxygen dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018796", "l": "4,5-dihydroxyphthalate decarboxylase activity", "d": ["Catalysis of the reaction: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9702818", "l": "CALCR binds erenumab (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56865", "l": "12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH => (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54752", "l": "methanophenazine + reduced coenzyme F420-(gamma-L-Glu)(n) = dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.5.98.3", "l": "\"coenzyme F420:methanophenazine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870465", "l": "RGGT binds the RAB-binding subunit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64795", "l": "L-lysine + NADP(+) <=> 2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3858489", "l": "ppDVL binds DAAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44745", "l": "4 H(+) + 4 malonyl-CoA => (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61260", "l": "H2O + L-glutamine + O2 = 2-oxoglutaramate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23384", "l": "D-cellobiose = beta-D-glucosyl-(1->4)-D-mannopyranose", "d": []}, {"i": "EC:5.1.3.11", "l": "\"cellobiose epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950456", "l": "IL12B dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113638", "l": "Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29108", "l": "H(+) + NADH + ubiquinone-8 => NAD(+) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72035", "l": "ATP(out) + 2 H(+)(out) + phosphate(in) = ATP(in) + 2 H(+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41200", "l": "1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4837364", "l": "Secretion of SOD3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62459", "l": "ATP + H(+) + L-glutamate <=> diphosphate + L-glutamyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674018", "l": "BRAP binds RAS:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44915", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH <=> (3E)-hexenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0045236", "l": "CXCR chemokine receptor binding", "d": ["Binding to a chemokine receptor in the CXCR family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617815", "l": "BBSome binds RAB3IP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70678", "l": "H2O + Met-enkephalin-Arg-Phe <=> L-arginyl-L-phenylalanine + Met-enkephalin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4093332", "l": "p-EPHB phosphorylates SDC2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3204303", "l": "MRE11 binds cytosolic DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000433", "l": "SUMOylation of PML with SUMO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68216", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1,2-dihexanoylglycerol = 1,2-dihexanoyl-3-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1861789", "l": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22441", "l": "UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine => H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727349", "l": "XDH dehydrogenates xanthine to form urate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25737", "l": "2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22847", "l": "(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23798", "l": "acetate + H(+) + norajmaline => 17-O-acetylnorajmaline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36689", "l": "CoA + H(+) + N-hexadecanoylsphing-4-enine => hexadecanoyl-CoA + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022359", "l": "MECP2:SIN3A complex binds GRIA2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49449", "l": "beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O => alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140997", "l": "histone H4 kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone H4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352840", "l": "glucose + ATP => glucose 6-phosphate + ADP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247922", "l": "GGCT transforms gGluCys to OPRO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74152", "l": "acetyl-CoA + L-lysyl-[beta-tubulin] => CoA + H(+) + N(6)-acetyl-L-lysyl-[beta-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381466", "l": "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73320", "l": "(2R,3S)-piscidate + (E)-4-coumaroyl-CoA => cimicifugate K + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21145", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19400", "l": "(R)-4'-phosphopantothenate + CTP + L-cysteine <=> CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43680", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48053", "l": "n 3'-phosphoadenylyl sulfate + dermatan => n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018828", "l": "halohydrin hydrogen-halide-lyase A activity", "d": ["Catalysis of the elimination of HCl from a chloro- or bromopropanol, yielding an epoxypropane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68611", "l": "Formation of ORC(1-5) complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449077", "l": "Interleukin-16 is secreted (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64644", "l": "butan-1-ol + propanoyl-CoA = butyl propanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050114", "l": "myo-inosose-2 dehydratase activity", "d": ["Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69173", "l": "Joining of adjacent Okazaki fragments (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3223236", "l": "RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189062", "l": "lactose + H2O => D-glucose + D-galactose (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879459", "l": "F-actin capping protein is a heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000327", "l": "PLK1 phosphorylates BORA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23064", "l": "an alkanesulfonate + FMNH2 + O2 = an aldehyde + FMN + 2 H(+) + H2O + sulfite", "d": []}, {"i": "EC:1.14.14.5", "l": "\"alkanesulfonate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35930", "l": "paromamine + UDP-alpha-D-glucose <=> 3''-deamino-3''-hydroxykanamycin C + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69471", "l": "2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose <=> L-glutamate + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798749", "l": "Exocytosis of specific granule lumen proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18668", "l": "(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) <=> (2R)-3-phosphoglycerate + [phosphate](n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73230", "l": "(3R)-citramalate(in) + sulfate(out) <=> (3R)-citramalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31069", "l": "Delta(1)-piperideine-2-carboxylate + H2O => 6-amino-2-oxohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905201", "l": "gibberellin transmembrane transporter activity", "d": ["Enables the transfer of gibberellin from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213017", "l": "Auto-ubiquitination of TRAF3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198813", "l": "GSTO dimers reduce DeHA to AscH- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73178", "l": "ADP(in) + FMN(out) <=> ADP(out) + FMN(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42003", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65677", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine => a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16972", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-4-dehydro-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37928", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683593", "l": "ATG7:ATG3:LC3 dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66009", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen] => [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434989", "l": "SEMA7A binds to PLXNC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51324", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = (8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205136", "l": "GTP-bound RAC contributes to JNK activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25059", "l": "(E)-cinnamate + H(+) + NADH + O2 => (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098770", "l": "FBXO family protein binding", "d": ["Binding to a member of the FBXO protein family. Members of this family have an F-box protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173739", "l": "Spontaneous hydrolysis of C3 thioester (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46774", "l": "a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77068", "l": "Activation of GT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33880", "l": "2-deoxy-scyllo-inosamine + NADP(+) => 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033910", "l": "glucan 1,4-alpha-maltotetraohydrolase activity", "d": ["Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotetraose residues from the non-reducing chain ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15619", "l": "Fe(2+) + Fe(III)-[cytochrome c] => Fe(3+) + Fe(II)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18780", "l": "an alkylmercury + H(+) <=> an alkane + Hg(2+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44512", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63757", "l": "flavokermesate + UDP-alpha-D-glucose => flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0036080", "l": "purine nucleotide-sugar transmembrane transporter activity", "d": ["Enables the transfer of a purine nucleotide-sugar from one side of a membrane to the other. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50793", "l": "18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => aldosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44931", "l": "2-oxoheptanedioate + acetyl-CoA + H2O <=> (R)-trihomocitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624948", "l": "KIF17 enters the cilium (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694462", "l": "ABHD6,12 hydrolyse 3AG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38007", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41139", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55555", "l": "N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74716", "l": "Insulin binds the insulin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36482", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA <=> (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31030", "l": "2-trans-(+)-abscisate + UDP-alpha-D-glucose <=> beta-D-glucopyranosyl trans-(+)-abscisate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507873", "l": "Aquaporins passively transport urea out of cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69923", "l": "castasterone + O2 + reduced [NADPH--hemoprotein reductase] = brassinolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70510", "l": "LDH tetramer oxidises LACT to PYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43836", "l": "cholesterol + H(+) + NADPH + O2 = 26-hydroxycholesterol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48192", "l": "(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33363", "l": "D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannitol 1-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.197", "l": "\"protein-N(pi)-phosphohistidine--D-mannitol phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45051", "l": "acetamide + H2O <=> acetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749505", "l": "LRRC14 binds IKBKB and CHUK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34405", "l": "(11R)-carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal => 9-cis-10'-apo-beta-carotenal + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13574", "l": "[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate => [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030412", "l": "formimidoyltetrahydrofolate cyclodeaminase activity", "d": ["Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H+ = 5,10-methenyltetrahydrofolate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59838", "l": "3-deoxyglucosone + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56358", "l": "2,4-dibromophenol + CO2 + 2 H2O + NADP(+) => 3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391939", "l": "TP receptor can bind thromboxane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48446", "l": "a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58327", "l": "beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64809", "l": "acetyl-CoA + O-(2-aminoethyl)-L-serine => CoA + H(+) + O-(2-acetamidoethyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41348", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25497", "l": "(2E)-geranyl diphosphate => (1S,5S)-beta-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37709", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624800", "l": "CDK1 phosphorylates LBR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002460", "l": "P4HB binds Collagen chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186780", "l": "Degradation of Ub-SMAD7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10143", "l": "NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981931", "l": "RAC1 and CDC42 activate PAK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322434", "l": "XIAP dissociates from ub-TLE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5632677", "l": "PTCH is internalized (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31680", "l": "O2 + prosolanapyrone II => H2O2 + prosolanapyrone III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983144", "l": "Transport of Antigen peptide in to ER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371467", "l": "SIRT1 deacetylates HSF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59655", "l": "D-xylotetraono-1,5-lactone + H2O <=> D-xylotetraonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163310", "l": "TFAM binds to mitochondrial promoters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59232", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = diphosphate + hydropyrenol", "d": []}, {"i": "EC:4.2.3.202", "l": "\"hydropyrenol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18505", "l": "L-lysine + NAD(+) = Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.15", "l": "\"lysine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045506", "l": "interleukin-24 receptor activity", "d": ["Combining with interleukin-24 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12134", "l": "ADP + Cd(2+)(out) + H(+) + phosphate => ATP + Cd(2+)(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174119", "l": "Free APC/C phosphorylated by Plk1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59393", "l": "acetyl-CoA + L-seryl-[protein] => CoA + O-acetyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46445", "l": "(11Z)-hexadecenoyl-CoA + AH2 + O2 => (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61934", "l": "(S)-miconazole(out) + ADP + H(+) + phosphate => (S)-miconazole(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621571", "l": "CD209 binds ICAM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368140", "l": "Expression of PPARGC1A (PGC-1alpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21936", "l": "carbamoyl phosphate + putrescine = H(+) + N-carbamoylputrescine + phosphate", "d": []}, {"i": "EC:2.1.3.6", "l": "\"putrescine carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32609", "l": "(6E)-8-hydroxygeranial + H(+) + NADPH => (6E)-8-hydroxygeraniol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222237", "l": "SMYD2 methylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19448", "l": "2,3-dihydroxyindole + O2 <=> anthranilate + CO2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73158", "l": "adenosine 3',5'-bisphosphate(out) + FMN(in) <=> adenosine 3',5'-bisphosphate(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48011", "l": "2-hydroxybenzoyl-CoA + H(+) + NADH + O2 <=> 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65817", "l": "AH2 + ATP + 2 Co(II)-[methylamine-specific corrinoid protein] + H2O => A + ADP + 2 Co(I)-[methylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001097", "l": "TFIIH-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174367", "l": "GCL ligates L-Glu to L-Cys (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901074", "l": "MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46299", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51227", "l": "2 Fe(III)-[cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36487", "l": "agmatine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.104", "l": "\"N(1)-aminopropylagmatine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70002", "l": "L-threonine(in) + Na(+)(in) <=> L-threonine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172126", "l": "DAP12 interacts with NKG2C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34918", "l": "D-galactose(in) <=> D-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24933", "l": "H(+) + hydrogen sulfide + NH4(+) + pyruvate => H2O + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35165", "l": "H(+)(in) + minocycline(out) => H(+)(out) + minocycline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72485", "l": "(S)-malate(out) + citrate(in) => (S)-malate(in) + citrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62679", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide <=> 6-thio-IMP + 7,8-dihydrofolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18340", "l": "D-ribose 5-phosphate + uracil <=> H2O + psi-UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9620103", "l": "ALDH2 transforms GTN to NO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061463", "l": "O-acetyl-ADP-ribose deacetylase activity", "d": ["Catalysis of the reaction O-acetyl-ADP-ribose + H2O = ADP-ribose + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48098", "l": "2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine => L-arginyl-[protein] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.49", "l": "\"bothropasin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719354", "l": "Defective DPM3 does not transfer mannose to DOLP to form DOLPman (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686578", "l": "Activated ATM phosphorylates ABL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17134", "l": "ATP + L-seryl-[tyrosine-3-monooxygenase] => ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72201", "l": "Ca(2+)(out) + 2 H(+)(in) => Ca(2+)(in) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72834", "l": "3',3'-cGAMP + H2O <=> G[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58283", "l": "4 ATP <=> cyclic tetraadenylate + 4 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619668", "l": "L-PRX:DRP:DGC:laminin-211 interacts with UTRN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21191", "l": "ATP + deamido-NAD(+) + NH4(+) <=> AMP + diphosphate + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944454", "l": "mTORC1 phosphorylates MAF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374337", "l": "Apelin receptor binds to apelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51532", "l": "H(+) + NADPH + O2 + urate = 5-hydroxyisourate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13151", "l": "AH2 + NADP(+) => A + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354077", "l": "Integrin alphaIIb beta3 activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.9", "l": "\"dihydroxy-acid dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850961", "l": "PREX2 binds PTEN and inhibits it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58342", "l": "chenodeoxycholate + D-glucose => beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655170", "l": "RCHY1 monoubiquitinates POLH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210298", "l": "Interaction of DAP12 and KIR3DS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40329", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850961", "l": "PREX2 binds PTEN and inhibits it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22874", "l": "CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen] => 2-oxoglutarate + L-prolyl-[collagen] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56008", "l": "4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694433", "l": "MIA2 binds PREB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42891", "l": "(R)-3-phosphomevalonate + ATP <=> (R)-3,5-bisphosphomevalonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.21", "l": "\"2-dehydro-3-deoxy-6-phosphogalactonate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10715", "l": "L-phenylalanine + O2 <=> 2-phenylacetamide + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140412", "l": "zinc:bicarbonate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) = zinc(in) + HCO3-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17933", "l": "a 7-hydroxyisoflavone + S-adenosyl-L-methionine = a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.150", "l": "\"isoflavone 7-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954082", "l": "E2F6 binds the PRC1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65745", "l": "2-oxoglutarate + decyl sulfate + O2 => CO2 + decanal + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043214", "l": "ABC-type bacteriocin transporter activity", "d": ["Enables the transfer of a bacteriocin from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73292", "l": "H(+)(out) + L-valine(in) => H(+)(in) + L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41111", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1013020", "l": "Activation of GIRK/Kir3 Channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0019966", "l": "interleukin-1 binding", "d": ["Binding to interleukin-1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432424", "l": "JET binds phosphorylated nuclear TIM, facilitating its ubiquitination (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43107", "l": "AH2 + an N-acyleicosasphinganine + O2 <=> A + an N-acyleicosasphing-4-enine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26200", "l": "H2O + melamine <=> ammeline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634861", "l": "NPAS4 binds ARNT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23012", "l": "a fatty acid + S-adenosyl-L-methionine = a fatty acid methyl ester + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.15", "l": "\"fatty-acid O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18346", "l": "a cis-3-alkyl-4-alkyloxetan-2-one => a cis-alkene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0051427", "l": "hormone receptor binding", "d": ["Binding to a receptor for a hormone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20211", "l": "ADP + H(+) + xylitol 5-phosphate => ATP + xylitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51750", "l": "4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38124", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol => 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981931", "l": "RAC1 and CDC42 activate PAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58369", "l": "(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) => (2E,6Z)-nona-2,6-dienal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102104", "l": "demethoxycurcumin synthase activity", "d": ["Catalysis of the reaction: (4-coumaroyl)acetyl-CoA + feruloyl-CoA + H2O <=> demethoxycurcumin + 2 coenzyme A + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928597", "l": "EPH:EFN dimers tetramerise (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675790", "l": "MTORC1 dissociates from ULK complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140670", "l": "cohesin unloader activity", "d": ["Facilitating a conformational change to unload a cohesin complex from sister chromatids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53964", "l": "4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin = gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]", "d": []}, {"i": "EC:2.3.2.19", "l": "\"ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164151", "l": "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64150", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-R + CMP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14036", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol <=> 1D-myo-inositol 1-phosphate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390329", "l": "Dephosphorylation of AKT by PP2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30392", "l": "4-methylsulfanyl-2-oxobutanoate + L-glutamine => 2-oxoglutaramate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55756", "l": "2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 = a 2-hydroxyornithine lipid + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.58", "l": "\"ornithine lipid ester-linked acyl 2-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58943", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADH <=> all-trans-lycopaoctaene + diphosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694433", "l": "MIA2 binds PREB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17365", "l": "ATP + H2O + Mn(2+)(out) = ADP + H(+) + Mn(2+)(in) + phosphate", "d": []}, {"i": "EC:7.2.2.5", "l": "\"ABC-type Mn(2+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35572", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] => (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56454", "l": "12-epi-hapalindole U => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52656", "l": "a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) = a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.211", "l": "\"long-chain-3-hydroxyacyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43938", "l": "androst-4-ene-3,17-dione => androst-5-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009916", "l": "alternative oxidase activity", "d": ["Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72621", "l": "Ribosomal scanning  (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1237129", "l": "Acireductone is created (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59918", "l": "(2E)-octenoate + 2 H(+) + NADPH => (2E)-octenal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72125", "l": "Na(+)(in) + O-butanoyl-(R)-carnitine(in) => Na(+)(out) + O-butanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75463", "l": "choline(out) + n H(+)(in) = choline(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033414", "l": "UGC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UGC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20751", "l": "2-oxoglutarate + O2 + penicillin N <=> CO2 + deacetoxycephalosporin C + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592297", "l": "Full activation of MMP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247840", "l": "WLS binds WNT ligands in the Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59090", "l": "(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine => D-histidine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68666", "l": "17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4570528", "l": "SUMOylation of XPC with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53150", "l": "H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9704297", "l": "CHRM2 binds CHRM2 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047798", "l": "cyclomaltodextrinase activity", "d": ["Catalysis of the reaction: H2O + cyclomaltodextrin = linear maltodextrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34269", "l": "CoA + fumigaclavine A => acetyl-CoA + fumigaclavine B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.77", "l": "\"protein-L-isoaspartate(D-aspartate) O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74838", "l": "UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-galactosamine(in) <=> UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-galactosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74096", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + an L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19614", "l": "dimethyl sulfide + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + trimethylsulfonium", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805126", "l": "AURKB phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49059", "l": "asperlicin C + H(+) + NADPH + O2 <=> asperlicin E + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28284", "l": "(S)-beta-macrocarpene => (S)-beta-bisabolene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950782", "l": "p-STAT1 binds p-STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210282", "l": "Interaction of GPVI and FceRI gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45207", "l": "Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol <=> H2O + methyl-Co(III)-[methanol-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254251", "l": "ERBB4s80 binds YAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65803", "l": "a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O <=> a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062153", "l": "C5-methylcytidine-containing RNA binding", "d": ["Binding to an RNA molecule modified by C5-methylcytidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372723", "l": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] <=> phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664850", "l": "ATM binds PEX5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52518", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10 => trans-4-hydroxy-L-proline + ubiquinone-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62895", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA <=> 6 CO2 + 7 CoA + 2 H2O + nor-toralactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42269", "l": "2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] => 4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5603467", "l": "Activated protein C is released from PROCR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050233", "l": "pyranose oxidase activity", "d": ["Catalysis of the reaction: D-glucose + O2 = 2-dehydro-D-glucose + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63523", "l": "2-isopropylphenol + H(+) + NADH + O2 <=> 3-isopropylcatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3786258", "l": "TP53 binds the CDKN1A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58461", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine => a monoacyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69164", "l": "H2O + N-(4-aminobutyl)-3-aminopropanal + NAD(+) = 2 H(+) + N-(2-carboxyethyl)putrescine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23119", "l": "4-hydroxybenzoate + ATP + CoA <=> 4-hydroxybenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40155", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.79", "l": "\"docosahexaenoic acid omega-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050647", "l": "5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding", "d": ["Binding to 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75516", "l": "H2O + N-acetyl-L-cysteine => acetate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801762", "l": "REG3A oligomerize to form a pore complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429157", "l": "ABCC4 accumulation of dense granule contents (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21881", "l": "2 H(+) + O2 + oxalate => 2 CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0031127", "l": "alpha-(1,2)-fucosyltransferase activity", "d": ["Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36718", "l": "sphinganine + tetracosenoyl-CoA <=> an N-tetracosenoylsphinganine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164514", "l": "Integrase binds viral DNA ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37329", "l": "ADP + H(+) + L-methionyl-L-alanine(in) + phosphate => ATP + H2O + L-methionyl-L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14189", "l": "D-tryptophan + O2 = N-formyl-D-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9713837", "l": "Psoralens in combination with UV generate DNA interstrand crosslinks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-213406", "l": "Disassociation of PLC-gamma1 from LAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38130", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol <=> 1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688834", "l": "ATXN3 binds VCP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46929", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24040", "l": "NADPH + 2 oxidized [cytochrome P450] = H(+) + NADP(+) + 2 reduced [cytochrome P450]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202969", "l": "Caspase mediated cleavage of beta-catenin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41918", "l": "3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + hexadecanoyl-[ACP] + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72753", "l": "L-phenylalanine + ochratoxin alpha => H2O + ochratoxin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64957", "l": "dTTP + 2 H2O => dTMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58387", "l": "NADP(+) + octan-1-ol <=> H(+) + NADPH + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102592", "l": "delphinidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent activity", "d": ["Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> violdelphin + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-354173", "l": "Activation of Rap1 by cytosolic GEFs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16570", "l": "2-oxoglutarate + L-lysyl-[collagen] + O2 => (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433592", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46607", "l": "[HPr protein]-O-phospho-L-serine + H(+) + phosphate <=> [HPr protein]-L-serine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43259", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708866", "l": "pro-F2R binds vorapaxar (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3245898", "l": "TCN1 binds correnoids in the circulation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201685", "l": "Beta-catenin is released from the destruction complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190141", "l": "ALAD binds to Pb2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48514", "l": "ADP + H(+) + phosphate + phosphinate(in) => ATP + H2O + phosphinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37328", "l": "ATP + H2O + L-methionyl-L-alanine(out) => ADP + H(+) + L-methionyl-L-alanine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14352", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose <=> an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48127", "l": "ganglioside GD3 (d18:1(4E)) + H2O <=> ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62899", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30521", "l": "diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine => GTP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29886", "l": "ATP + H2O + L-ornithine(out) <=> ADP + H(+) + L-ornithine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28810", "l": "glutathione + H2O <=> L-cysteinylglycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72631", "l": "Formation of the cap-binding eIF4F complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53335", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 <=> 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000433", "l": "SUMOylation of PML with SUMO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51635", "l": "all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43276", "l": "ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GalNAc-GD1a + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451377", "l": "Interaction of IQGAP1 with nephrin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64739", "l": "4-hydroxynonanal + NADP(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32005", "l": "diphosphate + isopimara-8(14),15-diene => (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47040", "l": "5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] = 5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": []}, {"i": "EC:2.8.1.14", "l": "\"tRNA-5-taurinomethyluridine 2-sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24383", "l": "(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705458", "l": "p-Y-STAT1,3,5 dimer enhances expression of SOCS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40495", "l": "N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2 = N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047872", "l": "dolichol O-acyltransferase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + dolichol = CoA + dolichyl palmitate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68876", "l": "ATP + H(+) + NADPH + piperonylate = AMP + diphosphate + NADP(+) + piperonal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.20", "l": "\"alpha-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050165", "l": "pantetheine kinase activity", "d": ["Catalysis of the reaction: ATP + pantetheine = ADP + pantetheine 4'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655483", "l": "USP1 autocleavage (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981093", "l": "IL12 bound to IL12R internalises (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654623", "l": "Activated FGFR3 binds FRS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12965", "l": "ATP + D-galacturonate = 1-phospho-alpha-D-galacturonate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.44", "l": "\"galacturonokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22735", "l": "4-hydroxyphenylacetate + H(+) <=> 4-methylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26333", "l": "2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O = 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin", "d": []}, {"i": "EC:2.8.1.12", "l": "\"molybdopterin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41278", "l": "H2O + N-eicosanoyl-sphing-4-enine <=> eicosanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196964", "l": "RFK:Mg2+ phosphorylates RIB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332236", "l": "CBL neddylates TGFBR2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20627", "l": "2 Fe(II)-[cytochrome c3] + 2 H(+) => 2 Fe(III)-[cytochrome c3] + H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46320", "l": "3beta-hydroxy-chol-5-ene-24-oyl-CoA + A = 3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990984", "l": "tRNA demethylase activity", "d": ["Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.-", "l": "\"Acting on GTP; involved in cellular and subcellular movement\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983285", "l": "RAD51B binds RAD51C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928627", "l": "EPHB phosphorylates TIAM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41739", "l": "3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) <=> adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9823816", "l": "OPTN binds CASP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20560", "l": "2 H(+) + H2O + urea <=> CO2 + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11640", "l": "a (2R,3R)-flavan-3-ol + 2 NAD(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694792", "l": "nsp12 misincorporates a nucleotide in nascent RNA minus strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070337", "l": "3'-flap-structured DNA binding", "d": ["Binding to a 3'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 3'-end of DNA or RNA protrudes from a double-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382056", "l": "Crk binds to the active PDGF receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202472", "l": "Translocation of TRAF6 to CBM complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13778", "l": "ATP + D-ribose 5-phosphate + NH4(+) => 5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57744", "l": "[protein]-disulfide + phylloquinol = [protein]-dithiol + phylloquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42658", "l": "diphthine-[translation elongation factor 2] + H(+) + methanol => diphthine methyl ester-[translation elongation factor 2] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58675", "l": "D-glucuronate <=> aldehydo-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696997", "l": "USP24 deubiquitinates DDB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34201", "l": "bracteatin 6-O-beta-glucoside + H2O => 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20272", "l": "4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate <=> 2 5-dehydro-4-deoxy-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392751", "l": "L1 linked to actin cytoskeleton by ankyrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0016415", "l": "octanoyltransferase activity", "d": ["Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60152", "l": "gamma-L-glutamyl-L-glutamyl-[protein] + H2O = L-glutamate + L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13321", "l": "(R)-3,3-dimethylmalate + NAD(+) = 3-methyl-2-oxobutanoate + CO2 + NADH", "d": []}, {"i": "EC:1.1.1.84", "l": "\"dimethylmalate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35577", "l": "(1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase] => (1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61359", "l": "ATP + H2O + methotrexate(in) <=> ADP + H(+) + methotrexate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49435", "l": "cholate + lithocholoyl-CoA <=> choloyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28967", "l": "L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047258", "l": "sphingosine beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: sphingosine + UDP-D-galactose = H+ + psychosine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088210", "l": "Cytosolic glycoconjugates translocate to the lysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46062", "l": "(5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000327", "l": "PLK1 phosphorylates BORA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12413", "l": "(2R)-3-phosphoglycerate + H2O => (R)-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41220", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034817", "l": "cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity", "d": ["Catalysis of the reaction: cis-9,10-dihydroanthracene-9,10-diol = 9,10-anthraquinone + 4 H+ + 4 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33613", "l": "H(+) + methanol + salicylate => H2O + methyl salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18427", "l": "3-dehydroquinate + H(+) + NADPH => L-quinate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23057", "l": "urea => cyanamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20057", "l": "2 H(+) + H2O + N-carbamoylsarcosine = CO2 + NH4(+) + sarcosine", "d": []}, {"i": "EC:3.5.1.59", "l": "\"N-carbamoylsarcosine amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28488", "l": "Fe(2+)(out) => Fe(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609899", "l": "Tail-anchored protein:ASNA1:ADP binds WRB:CAMLG at the endoplasmic reticulum membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30113", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-enterobactin + H(+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45126", "l": "acarbose 7(IV)-phosphate + ADP + H(+) => acarbose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002153", "l": "steroid receptor RNA activator RNA binding", "d": ["Binding to a steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014296", "l": "RAC2 GEFs activate RAC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14637", "l": "3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate", "d": []}, {"i": "EC:2.8.2.16", "l": "\"thiol sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102281", "l": "formylaminopyrimidine deformylase activity", "d": ["Catalysis of the reaction: formylaminopyrimidine + H2O <=> 4-amino-5-ammoniomethyl-2-methylpyrimidine + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655845", "l": "Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9676254", "l": "Formation of the MLL3 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66968", "l": "alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.380", "l": "\"GDP-Man:alpha-D-Man-(1->3)-alpha-D-Gal diphosphoundecaprenol alpha-1,2-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74764", "l": "rhamnetin + S-adenosyl-L-methionine => 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018756", "l": "RHOH binds GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20715", "l": "6-carboxyhexanoyl-CoA + H(+) + L-alanine <=> (8S)-8-amino-7-oxononanoate + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24989", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] => calcitroate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39602", "l": "3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8963864", "l": "CUBN dissociates from 25(OH)D (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51448", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] = alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417896", "l": "P2Y6 receptor can bind to UDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11226", "l": "ADP + D-alanyl-D-alanine + H(+) + phosphate => ATP + 2 D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49194", "l": "1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050566", "l": "asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73344", "l": "beta-alanyl-5'-AMP + holo-[peptidyl-carrier protein] => AMP + beta-alanyl-[peptidyl-carrier protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29803", "l": "ATP + H2O + L-valine(out) = ADP + H(+) + L-valine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019775", "l": "FAT10 transferase activity", "d": ["Catalysis of the transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y = Y-FAT10 + X, where both X-FAT10 and Y-FAT10 are covalent linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16162", "l": "2 Fe(III)-[leghemoglobin] + NADH => 2 Fe(II)-[leghemoglobin] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607043", "l": "factor VIIIa associates with cell membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202164", "l": "Translocation of PDK1 to Plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701488", "l": "Active ALK phosphorylates JAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690702", "l": "LYN phosphorylates CD22 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380782", "l": "STAT binds to the active receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65625", "l": "hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine => CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18380", "l": "ATP + streptomycin <=> ADP + H(+) + streptomycin 3''-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15279", "l": "CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin] => acetyl-CoA + L-lysyl-[alpha-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.59", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37765", "l": "1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372542", "l": "Loading of dopamine into synaptic veiscles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48849", "l": "(9Z,12Z)-octadecadienoate + O2 => 13-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39227", "l": "(2E)-octacosenoyl-CoA + H(+) + NADPH = NADP(+) + octacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58613", "l": "2 L-ascorbate + N-octanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71501", "l": "6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out) => 6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53212", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625421", "l": "The anterograde IFT train dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11271", "l": "D-cysteine + H2O <=> H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665998", "l": "MKL1 binds SRF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66466", "l": "scalarane-17alpha-19-diol => (2E,6E,10E,14E)-geranylfarnesol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.101", "l": "\"xanthomonalisin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27936", "l": "glycine + glyoxylate => (3S)-3-hydroxy-D-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004709", "l": "MAP kinase kinase kinase activity", "d": ["Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43902", "l": "beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+) => dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358790", "l": "RNF41 ubiquitinates ERBB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683719", "l": "Spike protein forms a homotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672961", "l": "PP2A dephosphorylates inactive RAFs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55737", "l": "alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose => [(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20618", "l": "L-galactono-1,4-lactone + O2 => H(+) + H2O2 + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683774", "l": "p-T68-CHEK2 dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354087", "l": "Recruitment of GRB2 to p-PTK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014449", "l": "RHOG binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45881", "l": "3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0072545", "l": "tyrosine binding", "d": ["Binding to 2-amino-3-(4-hydroxyphenyl)propanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74836", "l": "UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-galactosamine(in) => UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-galactosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604732", "l": "Autocatalytic activation of proMMP13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72408", "l": "H(+)(in) + Li(+)(out) => H(+)(out) + Li(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-874087", "l": "SGT1 binds HSP90 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46971", "l": "A + dihydroisopentenyldehydrorhodopin <=> AH2 + isopentenyldehydrorhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674022", "l": "BRAP autoubiquitinates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60792", "l": "3 2-oxoglutarate + gibberellin A53 + 3 O2 = 3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28623", "l": "(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40440", "l": "6-sulfo-beta-D-quinovose => 6-deoxy-6-sulfo-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769383", "l": "CBY1 binds beta-catenin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71040", "l": "L-methionine(in) + L-phenylalanine(out) => L-methionine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25558", "l": "diphosphate + stemod-13(17)-ene => 9alpha-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166015", "l": "Association of LBP with LPS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55211", "l": "(4R)-hydroxysphinganine 1-phosphate <=> (2R)-hydroxyhexadecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32541", "l": "(+)-car-3-ene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050397", "l": "Watasenia-luciferin 2-monooxygenase activity", "d": ["Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36211", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77094", "l": "Formation of cap binding complex (CBC) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51055", "l": "5alpha-androstan-3,17-dione + A <=> 5alpha-androst-1-ene-3,17-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18816", "l": "(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate <=> (3E,5R)-5-carboxy-2-oxohept-3-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50773", "l": "H2O + nitroethane + O2 => acetaldehyde + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1222376", "l": "NOX2 generates superoxide from oxygen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13244", "l": "ATP + L-fucose <=> ADP + beta-L-fucose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42521", "l": "uridine(2605) in 23S rRNA => pseudouridine(2605) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.2", "l": "\"ABC-type Cd(2+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54301", "l": "n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate => n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950190", "l": "Expression of PAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59834", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] => ATP + N(6)-(D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65038", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168136", "l": "Activated JNKs phosphorylate c-JUN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201457", "l": "BMP2 binds to the receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17237", "l": "ATP + FMN + H(+) = diphosphate + FAD", "d": []}, {"i": "EC:2.7.7.2", "l": "\"FAD synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61398", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16358", "l": "A + succinate => AH2 + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15081", "l": "acetate + ATP + CoA = acetyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15974", "l": "3'-phosphoadenylyl sulfate + estrone => adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27325", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853496", "l": "SCF:FBXL7 binds AURKA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9770142", "l": "Formation of the Spliceosomal B complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24605", "l": "7-methylxanthine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12785", "l": "an alditol + NAD(+) = an aldose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40633", "l": "2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate => H2O + trioctadecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432516", "l": "CLK and CYC bind to form a heterodimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013024", "l": "RHOB binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22110", "l": "2-oxobutanoate + NH4(+) => L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65913", "l": "3-hydroxy-L-kynurenine + pyruvate => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68145", "l": "ethyl 3-oxobutanoate + H(+) + NADPH => ethyl (R)-3-hydroxybutanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688797", "l": "ATXN3 family cleave Ub chains (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38359", "l": "2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 = thiosulfate + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450466", "l": "AUF1:mRNA complex is destroyed (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36963", "l": "(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58317", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955844", "l": "RBKS phosphorylates ribose to R5P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36886", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69017", "l": "3alpha-hydroxy-5beta-pregnan-20-one + NADP(+) => 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21648", "l": "H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O", "d": []}, {"i": "EC:4.2.1.51", "l": "\"prephenate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378952", "l": "Thyrotropin is a heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36169", "l": "a 2'-deoxyribonucleoside + phosphate => a 2'-deoxyribonucleoside 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50705", "l": "1-propanol + NAD(+) => H(+) + NADH + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21674", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21092", "l": "12-hydroxydihydrochelirubine + S-adenosyl-L-methionine = dihydromacarpine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.120", "l": "\"12-hydroxydihydrochelirubine 12-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10617", "l": "(2R,3S)-catechin + H2O + NADP(+) => (2R,3S,4S)-leucocyanidin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70090", "l": "methanol + o-quinone methide <=> hydroxyclavatol methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68924", "l": "ATP + H(+) + hexanoate + NADPH = AMP + diphosphate + hexanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67205", "l": "H2O + N-acetyltryptamine => acetate + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48374", "l": "a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) => 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74734", "l": "Re-integration of insulin receptor into plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17739", "l": "3-dehydroshikimate + H(+) + NADPH => NADP(+) + shikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9794475", "l": "Cipro:ALB dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850786", "l": "SPINK6 binds KLK12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29333", "l": "fumarate(out) + 2 H(+)(out) => fumarate(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106271", "l": "D-arabinose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-arabinose + NADP+ = D-arabinono-1,4-lactone + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41474", "l": "H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase] => ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109858", "l": "MAP2K2 binds MAPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45068", "l": "(R)-carnitine + an acyl-CoA = CoA + O-acyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72105", "l": "Na(+)(in) + O-propanoyl-(R)-carnitine(in) => Na(+)(out) + O-propanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35311", "l": "3-hydroxyisoheptadecanoyl-CoA + NADP(+) = 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3134962", "l": "DHX36 binds DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0019789", "l": "SUMO transferase activity", "d": ["Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75247", "l": "acetyl-CoA + N-terminal L-prolyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-prolyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9615249", "l": "ARBs bind AGRT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38651", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1449687", "l": "Corticosteroids bind to CBG in blood (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676133", "l": "CD74 binds MIF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72894", "l": "acetylcholine(out) + 2 H(+)(in) <=> acetylcholine(in) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39652", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O => 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22277", "l": "2-oxoaldehyde + H2O + NAD(+) => a 2-oxocarboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48575", "l": "3,5-dichlorocatechol + O2 <=> (2E,4E)-2,4-dichloromuconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218814", "l": "PAK2 autophorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67150", "l": "2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein] => L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38990", "l": "nonanoyl-CoA + O2 <=> (2E)-nonenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19203", "l": "ADP + dGMP + H(+) => 2'-deoxyguanosine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16605", "l": "dodecanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.2", "l": "\"decylcitrate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50514", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] => acetyl-CoA + N-terminal L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647977", "l": "ICMT methylates S-Farn RAS proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043919", "l": "agmatine aminopropyltransferase activity", "d": ["Catalysis of the reaction: agmatine + S-adenosylmethioninamine = N1-aminopropylagmatine + 5'-methylthioadenosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222020", "l": "NUAK1 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420206", "l": "Phosphorylation of SRC-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74383", "l": "2 (S)-lactate(in) + prostaglandin E2(out) = 2 (S)-lactate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56874", "l": "(S)-1-phenylethylamine + acetate => (S)-N-acetyl-1-phenylethylamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868657", "l": "Glucanotrehalose is hydrolyzed to 1,4-alpha-glucan and trehalose (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12472", "l": "H2O + N-ethylglycine + O2 = ethylamine + glyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46120", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69685", "l": "CHEK2 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098782", "l": "mechanosensitived potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by a channel that opens in response to a mechanical stress."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5334827", "l": "SUMO-CRABP2 binds atRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0034603", "l": "pyruvate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: pyruvate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9629679", "l": "PDE3A inhibitors bind PDE3A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62883", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2 <=> (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034945", "l": "2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity", "d": ["Catalysis of the reaction: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + CoASH = 3-isopropylbut-3-enoyl-CoA + propanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685838", "l": "CX3 complex binds D-loop structures (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47438", "l": "(3S)-hydroxy-(7Z-hexadecenoyl)-CoA => (2E,7Z)-hexadecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13342", "l": "a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050525", "l": "cutinase activity", "d": ["Catalysis of the reaction: cutin + H2O = cutin monomers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429694", "l": "CERT1-2 dissociates from the endoplasmic reticulum (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706393", "l": "RHOBTB3 binds ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34241", "l": "3-aminopentanedioate => L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41793", "l": "holo-[ACP] + malonyl-CoA => CoA + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43368", "l": "dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202966", "l": "Caspase mediated cleavage of HIP-55 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374689", "l": "Neogenin binds Netrin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68718", "l": "diphosphate + germacrene D => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45149", "l": "3-(methylsulfanyl)acryloyl-CoA + H2O => 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72323", "l": "3 Na(+)(out) + thiosulfate(out) = 3 Na(+)(in) + thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2769000", "l": "NOTCH1 PEST domain mutants bind DLL4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67518", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638845", "l": "CERK phosphorylates CERA to form C1P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34021", "l": "a fatty acid + glycerol + H(+) => a 1-acylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9736953", "l": "FURIN translocates to the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28461", "l": "biotin(in) <=> biotin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391942", "l": "IP receptor can bind prostacyclin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41975", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) <=> CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879594", "l": "SLCO4C1 mediates the transport of digoxin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52804", "l": "(2E,6E)-farnesyl diphosphate = (+)-eremophilene + diphosphate", "d": []}, {"i": "EC:4.2.3.164", "l": "\"(+)-eremophilene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15339", "l": "CoA + H(+) + phenylglyoxylate => H2O + phenylglyoxylyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46424", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102876", "l": "psoralen synthase activity", "d": ["Catalysis of the reaction: (+)-marmesin + NADPH + H+ + O2 <=> psoralen + NADP + acetone + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43390", "l": "1D-myo-inositol 3-phosphate + phosphate => 1D-myo-inositol 3,4-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51536", "l": "L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161790", "l": "20cooh-LTB4 is converted to 18cooh-LTB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9617927", "l": "FOXO4 binds ATXN3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13814", "l": "benzene + H(+) + NADH + O2 => cis-1,2-dihydrobenzene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210805", "l": "Removal of miRNA passenger strand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50166", "l": "20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45452", "l": "H2O + N-tetradecanoylethanolamine = ethanolamine + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73131", "l": "8-hydroxy-7-methoxyflavone + S-adenosyl-L-methionine = 7,8-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0090580", "l": "phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands", "d": ["Catalysis of the hydrolytic removal of phosphoglycolate from the 3'-terminus of a 3'-phosphoglycolate-terminated DNA strand."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17671", "l": "3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+) => 3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75809", "l": "Na(+)(in) + propanoate(in) => Na(+)(out) + propanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047992", "l": "hydroxylysine kinase activity", "d": ["Catalysis of the reaction: erythro-5-hydroxy-L-lysine + GTP = 5-phosphonooxy-L-lysine + GDP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32798", "l": "ATP + H2O + L-cysteine(out) <=> ADP + H(+) + L-cysteine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848335", "l": "IL37 binds  IL18R1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197963", "l": "DHFR2 reduces FOLA to DHF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34749", "l": "15-methylhexadecasphinganine 1-phosphate + ADP + H(+) => 15-methylhexadecasphinganine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20369", "l": "betaine aldehyde + H2O + O2 = glycine betaine + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800380", "l": "PTPRD binds IL1RAP-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30630", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) <=> (2S)-2-acetolactate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112437", "l": "Formation of NELF complex  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54903", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADH <=> hexadecanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48668", "l": "20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046510", "l": "UDP-sulfoquinovose:DAG sulfoquinovosyltransferase activity", "d": ["Catalysis of the reaction: UDP-sulfoquinovose + 1,2-diacylglycerol = sulfoquinovosyldiacylglycerol + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12207", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392263", "l": "AVP(20-28) binds AVPR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16174", "l": "(4-hydroxyphenyl)acetaldehyde + dopamine => (S)-norcoclaurine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58225", "l": "L-glutamyl-[protein] + NAD(+) => 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806957", "l": "MET receptor dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60030", "l": "4-terpineol + diphosphate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879459", "l": "F-actin capping protein is a heterodimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798748", "l": "Exocytosis of secretory granule lumen proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65501", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine => 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190662", "l": "Connexin oligomerization in Trans-Golgi Network (TGN) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10419", "l": "fumarate + toluene <=> 2-benzylsuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45213", "l": "acetyl-CoA + Co(I)-[corrinoid Fe-S protein] + H(+) => CO + CoA + methyl-Co(III)-[corrinoid Fe-S protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60373", "l": "D-fructose(out) => D-fructose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050611", "l": "arsenate reductase (azurin) activity", "d": ["Catalysis of the reaction: H2O + arsenite + 2 oxidized azurin = 2 H+ + 2 reduced azurin + arsenate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786881", "l": "TRNT1 polymerizes CCA at the 3' end of pre-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68610", "l": "3-hydroxyindolin-2-one + NADP(+) => H(+) + isatin + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72801", "l": "L-arginine(in) + L-homoarginine(out) => L-arginine(out) + L-homoarginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70723", "l": "sitosterol(out) = sitosterol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63169", "l": "fumarate + L-cysteine => S-(2-succino)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1170539", "l": "Prolactin receptor is internalized (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102696", "l": "cis-zeatin UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cis-zeatin = H+ + 9-(alpha-D-glucosyl)-cis-zeatin + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111915", "l": "CAMK4 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69569", "l": "(2S)-2-amino-4-deoxychorismate + H2O + L-glutamine => 4-amino-4-deoxychorismate + L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54063", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (2Z,6E)-hedycaryol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55776", "l": "all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate = all-trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70596", "l": "GOT2 dimer deaminates L-Asp (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874082", "l": "MET phosphorylates PTK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34949", "l": "3-oxopropanoate + NH4(+) => (Z)-3-aminoacrylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21532", "l": "ATP + glutathione + glutathionylspermidine = ADP + H(+) + phosphate + trypanothione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22713", "l": "adenosylcob(III)inamide phosphate + GTP + H(+) => adenosylcob(III)inamide-GDP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52433", "l": "(R)-2,3-diaminopropanoate + H(+) + H2O => 2 NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19110", "l": "1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose => 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64269", "l": "emodin anthrone + O2 => emodin + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36930", "l": "(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37857", "l": "1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57540", "l": "a 5'-end NTP-ribonucleotide-RNA + H2O = a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18656", "l": "barbiturate + H2O <=> 3-oxo-3-ureidopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74685", "l": "4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether + 4 H(+) + 4 L-methionine => 2 AH2 + 2 archaeol + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080070", "l": "8-methylthiooctyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 8-methylthiooctyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 8-methylthiooctyl-glucosinolate + adenosine 3',5'-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875443", "l": "USP8 deubiquitinates LRIG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33068", "l": "(4R)-hydroxysphinganine 1-phosphate + H2O => (4R)-hydroxysphinganine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080122", "l": "AMP transmembrane transporter activity", "d": ["Enables the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21843", "l": "N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49256", "l": "2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] = 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.203", "l": "\"protein-N(pi)-phosphohistidine--D-glucosaminate phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008994", "l": "rhamnulose-1-phosphate aldolase activity", "d": ["Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015087", "l": "cobalt ion transmembrane transporter activity", "d": ["Enables the transfer of cobalt (Co) ions from one side of a membrane to the other."]}, {"i": "RHEA:28578", "l": "Co(2+)(in) = Co(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67213", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + O2 => (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51225", "l": "2 Fe(III)-[cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate => 2 Fe(II)-[cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042608", "l": "T cell receptor binding", "d": ["Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193964", "l": "CYP21A2 21-hydroxylates PROG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604752", "l": "Initial activation of proMMP13 by MMP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67347", "l": "kaempferol 7-O-beta-D-glucoside + malonyl-CoA <=> CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005307", "l": "choline:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-606326", "l": "HJURP:CENPA complex localizes to the centromere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203611", "l": "N-myristoylation of eNOS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37336", "l": "5,6-dihydrothymine + H2O => 3-(carbamoylamino)-2-methylpropanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75244", "l": "FASL binds FAS Receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40639", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12076", "l": "an aromatic primary alcohol + NAD(+) = an aromatic aldehyde + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.90", "l": "\"aryl-alcohol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31603", "l": "(Z)-3-ureidoacrylate + H2O = (Z)-3-aminoacrylate + carbamate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67535", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17184", "l": "a long-chain fatty aldehyde + FMNH2 + O2 <=> a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46718", "l": "H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine => pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46315", "l": "3-oxochol-4-en-22-oyl-CoA + acetyl-CoA <=> 3,22-dioxochol-4-en-24-oyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008545", "l": "JUN kinase kinase activity", "d": ["Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase."]}, {"i": "REACT:R-HSA-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109858", "l": "MAP2K2 binds MAPK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24571", "l": "a 6-phospho-beta-D-galactoside + H2O <=> an alcohol + D-galactose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862700", "l": "CMKLR1 binds Resolvin E1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0038106", "l": "choriogonadotropin hormone binding", "d": ["Binding to choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69425", "l": "2-hydroxyisobutanoyl-CoA => acetone + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40152", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209094", "l": "Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0099181", "l": "structural constituent of presynapse", "d": ["The action of a molecule that contributes to the structural integrity of a presynapse."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37256", "l": "A + D-asparagine + H2O => 2-oxosuccinamate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354077", "l": "Integrin alphaIIb beta3 activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49872", "l": "(+)-dehydrodiconiferyl acid ketone + a quinone + H2O = (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6795460", "l": "SGK1 phosphorylates MDM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380780", "l": "Activation of Src (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102944", "l": "medicagenate UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose(2-) + medicagenate <=> UDP(3-) + a medicagenate monoglucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71592", "l": "2-oxoglutarate(out) + malonate(in) => 2-oxoglutarate(in) + malonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657775", "l": "Expression of ANGPTL3 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240765", "l": "E2F1/2/3:DP1/2 binds EED gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10957", "l": "(E)-cinnamate + H(+) + NADPH + O2 => H2O + NADP(+) + trans-2-coumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25823", "l": "H2O + O2 + spermidine <=> 4-aminobutanal + H2O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047862", "l": "diisopropyl-fluorophosphatase activity", "d": ["Catalysis of the reaction: diisopropyl fluorophosphate + H2O = diisopropyl phosphate + 2 H+ + hydrogen fluoride."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709360", "l": "H2O2 reduces MetHb (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73517", "l": "UDP(in) + UTP(out) => UDP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46509", "l": "NADH + nitrobenzene + O2 => catechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74422", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25943", "l": "8-chloroquinoline + A + H2O <=> 8-chloroquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60559", "l": "uridine(35) in tRNA(Tyr) <=> pseudouridine(35) in tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429449", "l": "Syk activation leads to SLP-76 activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951676", "l": "RUNX3 binds TEADs and YAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45627", "l": "ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine <=> AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52406", "l": "CO2 + dihydroxyacetone phosphate => 3-dehydro-4-O-phospho-L-erythronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51621", "l": "CTP + formate + H(+) => CO2 + dCTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237129", "l": "Acireductone is created (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005213", "l": "structural constituent of egg chorion", "d": ["The action of a molecule that contributes to the structural integrity of an egg chorion. An example of this is found in Drosophila melanogaster."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483089", "l": "PE is converted to PS by PTDSS2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674019", "l": "BRAP binds KSR1:MARK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35127", "l": "L-alanyl-D-glutamate(out) = L-alanyl-D-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050118", "l": "N-acetyldiaminopimelate deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-LL-2,6-diaminopimelate + H2O = LL-2,6-diaminopimelate + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72770", "l": "acetyl-CoA + 9 H(+) + 4 malonyl-CoA + 5 NADPH <=> 7-methylmellein + 3 CO2 + 5 CoA + 4 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31797", "l": "(+)-caryolan-1-ol => (+)-(E)-beta-caryophyllene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32488", "l": "CDP-choline + H2O => CMP + 2 H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65639", "l": "sphinga-(4E,8E)-dienine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983394", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60691", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NAD(+) <=> (11R)-dihydroartemisinate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49834", "l": "a fatty acid + 2 H(+) + NADH => a fatty aldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132136", "l": "Vitronectin binds to C5b-C7 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13408", "l": "4-coumaroyl-CoA + agmatine <=> CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-517705", "l": "p-S318,221-HuR binds mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633414", "l": "TP53 binds TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52634", "l": "[amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44495", "l": "3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67833", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(27)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(27)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58134", "l": "AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine => A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140769", "l": "factor VII -> factor VIIa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63607", "l": "[Pyr1]apelin-13 + H2O <=> [Pyr1]apelin-12 + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.13", "l": "\"clostridial aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794352", "l": "Basolateral transport of Cipro into intestinal cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008690", "l": "3-deoxy-manno-octulosonate cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404193", "l": "IGF1R phosphorylates SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109639", "l": "Formation of the closed pre-initiation complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047820", "l": "D-glutamate cyclase activity", "d": ["Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10772", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O = D-glucose + D-glucose 6-phosphate", "d": []}, {"i": "EC:3.2.1.86", "l": "\"6-phospho-beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63973", "l": "A + dihydropyriculol => AH2 + pyriculol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52191", "l": "1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione <=> (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18275", "l": "4-aminobutanal + H2O2 + NH4(+) => H2O + O2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198756", "l": "ERK1/2 phosphorylates MSK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689317", "l": "Formation of the pre-incision complex in GG-NER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443831", "l": "14-3-3-zeta binds Raf1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380311", "l": "Recruitment of Plk1 to centrosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32313", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299318", "l": "Activation of TASK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75480", "l": "S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) => S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24072", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34957", "l": "5-(methylsulfanyl)-D-ribose(out) => 5-(methylsulfanyl)-D-ribose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69132", "l": "cadaverine + H2O + O2 = 5-aminopentanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49082", "l": "dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O => dibenzothiophene 5-oxide + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70719", "l": "L-alanine(in) = L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14376", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9007882", "l": "IL1F10 is cleaved (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.205", "l": "\"galactogen 6beta-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102551", "l": "homogentisate geranylgeranyl transferase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + homogentisate + H+ <=> diphosphoric acid + 2-methyl-6-geranylgeranyl-1,4-benzoquinol + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72809", "l": "L-histidine(in) => L-histidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51308", "l": "H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2172678", "l": "PHF8 demethylates histone H4K20me1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.3", "l": "\"kynureninase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47921", "l": "ganglioside GM2 (d18:1(4E)/18:0) + H2O => ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5676229", "l": "WIPIs bind PI3P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102595", "l": "cyanidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-glucoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> cyanidin 3-O-glucoside-7-O-(6-O-(4-O-(6-O-(p-hydroxybenzoyl)-glucosyl)-oxybenzoyl)-glucoside) + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42542", "l": "pseudouridine(13) in tRNA => uridine(13) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41853", "l": "H(+) + malonyl-[ACP] + octanoyl-[ACP] => 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52451", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate <=> 16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034785", "l": "salicylate 5-hydroxylase activity", "d": ["Catalysis of the reaction: salicylate + O2 + NAD(P)H + H+ = gentisate + H2O + NAD(P)+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395340", "l": "Formation of hydroxyallysine by LOX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68420", "l": "cis-(homo)3aconitate + H2O = (2R,3S)-iso(homo)3citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68421", "l": "cis-(homo)3aconitate + H2O => (2R,3S)-iso(homo)3citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53864", "l": "3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+) = 7,12-dioxo-lithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48935", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b <=> CMP + ganglioside GQ1b + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210439", "l": "glutamate uptake by astrocytes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65149", "l": "phloretin + UDP-alpha-D-glucose => H(+) + trilobatin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805943", "l": "S100A1 binds TLR4:LY96 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709317", "l": "CO binds to free ferrohemoglobin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31490", "l": "soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose <=> H(+) + soyasaponin III + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15020", "l": "a phosphate monoester + H2O <=> an alcohol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47113", "l": "chenodeoxycholate + glycine => glycochenodeoxycholate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43866", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51952", "l": "(E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004592", "l": "pantoate-beta-alanine ligase activity", "d": ["Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656212", "l": "Phosphorylation of RAF1 mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68697", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16472", "l": "(R)-2-benzylsuccinate + succinyl-CoA <=> (R)-2-benzylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879930", "l": "STAT5 is recruited by JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32229", "l": "(6S)-NADPHX => (6R)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15271", "l": "H(+) + L-ascorbate => L-xylo-hex-3-ulonolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848339", "l": "PNPLA5 hydrolyzes TAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672948", "l": "MARK3 phosphorylates KSR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449958", "l": "IL7:IL7R:JAK1 binds IL2RG:JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75309", "l": "D-serine(out) + L-glutamine(in) + Na(+)(in) => D-serine(in) + L-glutamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612509", "l": "SGK phosphorylates SRF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917696", "l": "Cargo Sequestration (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19158", "l": "D-xylonate => 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71220", "l": "2 Na(+)(out) + nitrate(out) => 2 Na(+)(in) + nitrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70345", "l": "3-chloro-L-tyrosine + NADPH => chloride + L-tyrosine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21497", "l": "dimethylallyl diphosphate + H2O => diphosphate + prenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47986", "l": "diphosphate + hydroxysqualene => H2O + presqualene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14017", "l": "ATP + beta-nicotinamide D-riboside = ADP + beta-nicotinamide D-ribonucleotide + H(+)", "d": []}, {"i": "EC:2.7.1.22", "l": "\"ribosylnicotinamide kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70214", "l": "2-oxoglutarate + GDP-D-glycero-alpha-D-manno-heptose <=> (S)-2-hydroxyglutarate + GDP-D-glycero-4-keto-alpha-D-lyxo-heptose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389348", "l": "Activation of Rac1 by pVav1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72763", "l": "anthocyanin A10 + malonyl-CoA = anthocyanin A11 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801101", "l": "RABGGTA binds RABGGTB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50214", "l": "11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53506", "l": "5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140360", "l": "cyclic-GMP-AMP transmembrane transporter activity", "d": ["Enables the transfer of cyclic-GMP-AMP from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37861", "l": "1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22837", "l": "a fatty acyl-[ACP] + H(+) + malonyl-[ACP] => a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70982", "l": "4-aminobutanoate(out) + n H(+)(in) <=> 4-aminobutanoate(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109858", "l": "MAP2K2 binds MAPK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018573", "l": "NOTCH3 binds activated EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37902", "l": "2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 <=> 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12723", "l": "H(+) + S-methyl-5'-thioadenosine + spermidine => putrescine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132206", "l": "MASPs activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717182", "l": "L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP and GNAT3:GTP, and GNB1,3:GNG13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53999", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936676", "l": "Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52457", "l": "testosterone + UDP-alpha-D-glucuronate => H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27665", "l": "(S)-2-hydroxyglutarate + O2 <=> 2-oxoglutarate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71757", "l": "2-oxoglutarate(in) + 2-oxoheptanedioate(out) => 2-oxoglutarate(out) + 2-oxoheptanedioate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65463", "l": "acetyl-CoA + hexan-1-ol <=> CoA + hexyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009488", "l": "IL34 binds CSF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685542", "l": "Viral release (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43623", "l": "L-serine + NADP(+) <=> aminoacetaldehyde + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28397", "l": "L-alanyl-L-glutamate <=> L-alanyl-D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50186", "l": "N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15824", "l": "2 A + glycine <=> 2 AH2 + CO2 + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.909905611858392", "identifiers": [{"i": "GO:0003677", "l": "DNA binding", "d": ["Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69518", "l": "H2O2 + N-acetyl-D-galactosamino-1,5-lactone => N-acetyl-D-galactosamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62890", "l": "beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+) => GDP-beta-L-fucose + lactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70335", "l": "2-carboxy-L-lyxonolactone + H2O = 2-carboxy-L-lyxonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58150", "l": "acetate + ethanol + H(+) => ethyl acetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784189", "l": "JAKs bind LIFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408509", "l": "Sec-tRNA(Sec) binds to EEFSEC:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799350", "l": "Exocytosis of specific granule membrane proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39161", "l": "(2E)-hexadecenoyl-CoA + H2O => (3R)-hydroxyhexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27719", "l": "H2O + IMP => inosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848596", "l": "PTK6 binds PXN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627775", "l": "Autophosphorylation of PAK1,2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21911", "l": "NADP(+) + scytalone <=> H(+) + NADPH + naphthalene-1,3,6,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033426", "l": "CAC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CAC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448632", "l": "IL34 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "64.855413419593077", "identifiers": [{"i": "GO:0005272", "l": "sodium channel activity", "d": ["Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018794", "l": "RHOV binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60012", "l": "a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20972", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine = 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}, {"i": "EC:2.3.1.148", "l": "\"glycerophospholipid acyltransferase (CoA-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74726", "l": "Dissociation of insulin from insulin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0052834", "l": "inositol monophosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52048", "l": "9-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652264", "l": "ERBB2 binds TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56168", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48392", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66099", "l": "3-phenylpyruvate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381087", "l": "Dimerization of PERK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983696", "l": "The Immunoglobulin of the BCR binds antigen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047734", "l": "CDP-glycerol diphosphatase activity", "d": ["Catalysis of the reaction: CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10633", "l": "D-mannonate + NAD(+) => D-mannuronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17720", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP <=> 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17898", "l": "A + ethylbenzene + H2O => (S)-1-phenylethanol + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69955", "l": "Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43538", "l": "4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate => 2 D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61884", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180009", "l": "broad specificity neutral L-amino acid:basic L-amino acid antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: basic L-amino acid(in) + neutral L-amino acid(out) = basic L-amino acid(in) + neutral L-amino acid(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606602", "l": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36158", "l": "AH2 + Co(II)-factor III + S-adenosyl-L-methionine <=> A + Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.99.-", "l": "\"Acting on other compounds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034822", "l": "citronellal dehydrogenase activity", "d": ["Catalysis of the reaction: citronellal + NAD+ + OH- = citronellate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399712", "l": "Activation of Ca permeable AMPA receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42000", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44735", "l": "2-(9Z,12Z-octadecadienoyl)-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75635", "l": "(9Z)-octadecenoate + O2 = 10-hydroperoxy-(8E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047284", "l": "dolichyl-xylosyl-phosphate-protein xylosyltransferase activity", "d": ["Catalysis of the reaction: dolichyl D-xylosyl phosphate + protein = dolichol-phosphate + D-xylosylprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26083", "l": "(Z)-gamma-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141409", "l": "Mad1 binds kinetochore (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65553", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O => an N-acyl-sphingoid base + lactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66633", "l": "L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71509", "l": "(+)-alpha-tocopherol(in) => (+)-alpha-tocopherol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75919", "l": "H2O + NADP(+) + serinol = dihydroxyacetone + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44349", "l": "ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide B + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160915", "l": "Receptor-mediated uptake of HA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75238", "l": "TRAIL binds TRAIL receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66358", "l": "(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH => (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55968", "l": "(+)-kolavelool + S-adenosyl-L-methionine = (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.347", "l": "\"(+)-O-methylkolavelool synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660662", "l": "ASC binds Caspase-8 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44640", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694409", "l": "Nucleotide exchange on RAB1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32173", "l": "2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+) => H(+) + NADPH + O2 + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111966", "l": "GRK2 binds CALM1:4Ca2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0051864", "l": "histone H3K36 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004742", "l": "dihydrolipoyllysine-residue acetyltransferase activity", "d": ["Catalysis of the reaction: (R)-N6-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N6-(S8-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140703", "l": "3',3'-cyclic GMP-AMP binding", "d": ["Binding to 3',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 3',5' linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54487", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine <=> 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199169", "l": "MHC Class I interacts with CD160 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68983", "l": "NADP(+) + tauroursodeoxycholate <=> 7-oxotaurolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13951", "l": "NADPH + 2 oxidized [rubredoxin] => H(+) + NADP(+) + 2 reduced [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21626", "l": "FMN + 2 H(+) + NADPH => FMNH2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27607", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187382", "l": "Degradation of ubiquitinated SMAD3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22555", "l": "3'-phosphoadenylyl sulfate + an alcohol <=> adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55525", "l": "H(+) + H2O + L-dopa + O2 => 3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75726", "l": "(9Z,12Z)-octadecadienoate + H2O <=> (10S)-hydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75235", "l": "L-fucono-1,5-lactone = L-fucono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46428", "l": "4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850997", "l": "TRIM27 binds PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5627775", "l": "Autophosphorylation of PAK1,2,3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21775", "l": "cytidine(6666) in apoB mRNA + H(+) + H2O <=> NH4(+) + uridine(6666) in apoB mRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45020", "l": "L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.298", "l": "\"ribosomal protein L3 N(5)-glutamine methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73092", "l": "AMP(out) + FMN(in) => AMP(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693536", "l": "ATM phosphorylates MDC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400492", "l": "PCSK1 hydrolyzes proGIP to GIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928656", "l": "gamma-secretase cleaves EPHB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17909", "l": "(S)-lactate = acetaldehyde + formate", "d": []}, {"i": "EC:4.1.2.36", "l": "\"lactate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6790454", "l": "SUMOylation of XPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76426", "l": "N-atom dealkylation of caffeine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59265", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052759", "l": "coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity", "d": ["Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex + H- = trinitrophenol dihydride Meisenheimer complex (aci form). Coenzyme F420 supplies the hydride (H-) in the reaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956639", "l": "RUNX1 binds YAP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380574", "l": "Dopamine synaptic vesicle docking and priming (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050273", "l": "S-succinylglutathione hydrolase activity", "d": ["Catalysis of the reaction: S-succinylglutathione + H2O = glutathione + H+ + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694583", "l": "ABHD4 hydrolyses NAPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26407", "l": "H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655270", "l": "Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4827388", "l": "CTNNB1 S45 mutants aren't phosphorylated by CK1alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017855", "l": "NICD3 binds to TACC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3777129", "l": "HDAC3 containing complexes deacetylate histone (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27899", "l": "3'-AMP + H2O => adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662096", "l": "Exocytosis of glutamate from cochlear inner hair cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61232", "l": "H2O + L-isoleucine + O2 = (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20658", "l": "4-chlorophenylacetonitrile + 2 H2O => 4-chlorophenylacetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660666", "l": "CBP and p300 binds NF-kB complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62216", "l": "isoepoxydon + NADP(+) = H(+) + NADPH + phyllostine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45074", "l": "(9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473184", "l": "Follistatin (FST) binds Activin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102041", "l": "7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase", "d": ["Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203979", "l": "Coat Assembly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30770", "l": "D-glucurono-3,6-lactone + H2O <=> D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56811", "l": "ATP + cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] <=> adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44906", "l": "alpha-D-glucose + phosphate => alpha-D-glucose 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357828", "l": "RIPK1 is cleaved by CASP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65030", "l": "(+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin] => (+)-pinoresinol + H2O + 2 oxidized [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0097508", "l": "xanthine DNA N-glycosylase activity", "d": ["DNA N-glycosylase activity acting on deaminated guanine (xanthine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029268", "l": "Phosphorylation and activation of PLCG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102122", "l": "gibberellin A34 carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: gibberellin A34 + S-adenosyl-L-methionine = gibberellin A34 methyl ester + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47366", "l": "an aliphatic alcohol + dodecanoate + H(+) => a dodecanoate ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11622", "l": "2-oxopent-4-enoate + chloride + H(+) + NH4(+) => H2O + L-2-amino-4-chloropent-4-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32639", "l": "(6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase] = (6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698762", "l": "FLT3 ITD- and STAT5-dependent NOX4 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24598", "l": "CoA + H(+) + N(alpha)-acetyl-L-histidine => acetyl-CoA + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864569", "l": "WWOX binds TFAP2C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47046", "l": "acetoacetate + N,N,N-trimethylglycyl-CoA => 3-dehydrocarnitine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22830", "l": "1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+) => 1-(5-phospho-beta-D-ribosyl)-ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445069", "l": "L1-EGFR trans-heterodimerization (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5323526", "l": "FRAT proteins bind GSK3beta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61283", "l": "4-aminobutanoate + H2O + O2 <=> H2O2 + NH4(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55927", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036219", "l": "GTP diphosphatase activity", "d": ["Catalysis of the reaction: GTP + H2O = GMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63110", "l": "ascofuranol => 16-hydroxy-ilicicolin A epoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57890", "l": "a quinol + 4 H(+)(out) + NAD(+) => a quinone + 5 H(+)(in) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204958", "l": "NRAGE sequesters CHE1 in the cytoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12257", "l": "L-arogenate + NAD(+) => CO2 + L-tyrosine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019534", "l": "toxin transmembrane transporter activity", "d": ["Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388560", "l": "EDNRA,EDNRB bind EDNs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56817", "l": "a pyrimidine ribonucleoside + H2O => a pyrimidine nucleobase + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786092", "l": "IL4:IL4R:JAK2 binds IL2RG:JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10132", "l": "ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate", "d": []}, {"i": "EC:6.2.1.25", "l": "\"benzoate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42871", "l": "norspermine + S-adenosyl 3-(methylsulfanyl)propylamine <=> caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20162", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose => myo-inositol + raffinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31322", "l": "(2R)-3-phosphoglycerate + UDP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43436", "l": "coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2", "d": []}, {"i": "EC:1.3.3.15", "l": "\"coproporphyrinogen III oxidase (coproporphyrin-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44435", "l": "2 a 1-acylglycerol <=> a 1,2-diacylglycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627106", "l": "SMAC (DIABLO) forms dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17238", "l": "ATP + FMN + H(+) => diphosphate + FAD", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38800", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052856", "l": "NADHX epimerase activity", "d": ["Catalysis of the reaction: (R)-NADHX = (S)-NADHX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17100", "l": "3-phenylpyruvate <=> enol-phenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391935", "l": "DP1 receptor can bind PGD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40366", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70909", "l": "(2R)-3-phosphoglycerate + alpha-D-mannose 1,6-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37609", "l": "1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61926", "l": "(2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate => (2S,4R)-ketoconazole(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035375", "l": "zymogen binding", "d": ["Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22216", "l": "(E)-caffeate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)", "d": []}, {"i": "EC:1.13.11.22", "l": "\"caffeate 3,4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34975", "l": "(R)-pantothenate(in) = (R)-pantothenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74010", "l": "dimethylallyl diphosphate + H2O + yaequinolone E <=> [(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624133", "l": "ARL3:GTP binds the UNC119B complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-593672", "l": "Myosin-X binds DCC/Neogenin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209224", "l": "SLMB binds to and ubiquitinates phosphorylated CI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102534", "l": "apigenin-7,4'-dimethyl ether 6-hydroxylase activity", "d": ["Catalysis of the reaction: apigenin-7,4'-dimethyl ether + O2 + NADPH + H+ <=> ladanein + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54199", "l": "N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37724", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53794", "l": "benzothialdehyde + H2O2 => benzylthiol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-164617", "l": "Elongation of Extended Telomeric Chromosome End (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67019", "l": "a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14865", "l": "S-adenosyl-L-methionine + tyramine = H(+) + N-methyltyramine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.27", "l": "\"tyramine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24924", "l": "L-homoserine => 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33200", "l": "butan-1-ol + NAD(+) => butanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34062", "l": "agroclavine + NADP(+) <=> didehydroagroclavine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70793", "l": "H(+)(out) + L-ornithine(in) => H(+)(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004018", "l": "N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity", "d": ["Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948775", "l": "MKRN1 polyubiquitinates PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.7", "l": "\"ferredoxin--NAD(P)(+) reductase (naphthalene dioxygenase ferredoxin-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033780", "l": "taurochenodeoxycholate 6alpha-hydroxylase activity", "d": ["Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O, and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52940", "l": "chenodeoxycholate + UDP-alpha-D-glucuronate = chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632182", "l": "PRMT1 methylates ESRs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65895", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate <=> H2O + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52102", "l": "(9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+) => 5-(9Z-octadecenoyloxy)-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44943", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O <=> 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49593", "l": "2-hydroxyisobutanoyl-CoA => (3S)-3-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38316", "l": "chorismate => 3-hydroxybenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34841", "l": "5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O => 4 H(+) + 5 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73227", "l": "(3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50741", "l": "H2O + leukotriene C4 => glycine + leukotriene F4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624956", "l": "PDE6D binds INPP5E (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425923", "l": "IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52033", "l": "H2O + L-isoleucine-(+)-7-isojasmonate => (+)-7-isojasmonate + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674022", "l": "BRAP autoubiquitinates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24861", "l": "pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose = H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944227", "l": "Association of procollagen type XXII (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618559", "l": "EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54508", "l": "all-trans-heptaprenyl diphosphate = beta-heptaprene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0141055", "l": "histone H3 ubiquitin ligase activity", "d": ["Catalysis of the transfer of ubiquitin to a histone H3 substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374680", "l": "L1 trans-homophilic interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23350", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2 => (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354060", "l": "Translocation of RIAM to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16102", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate => n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25849", "l": "(1S,5S)-carveol + NAD(+) => (S)-carvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373741", "l": "SDK2 homophillic interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1008200", "l": "NFE2 binds the beta globin locus control region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41964", "l": "butanoyl-CoA + O2 = (2E)-butenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71800", "l": "Ca(2+)(in) + H(+)(out) => Ca(2+)(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12718", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12087", "l": "D-mannitol + NAD(+) <=> D-fructose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0015137", "l": "citrate transmembrane transporter activity", "d": ["Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40852", "l": "FAD + H(+) + pentadecanoyl-CoA => (2E)-pentadecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19990", "l": "S-methyl-5-thio-alpha-D-ribose 1-phosphate => S-methyl-5-thio-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29997", "l": "ADP + H(+) + phosphate + putrescine(in) => ATP + H2O + putrescine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102823", "l": "kaempferol-3-rhamnoside-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + kaempferol-3-rhamnoside <=> kaempferol 3-O-rhamnoside-7-O-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66743", "l": "ATP + H2O + N-acetyl-L-glutamate(in) <=> ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38874", "l": "uridine(2457) in 23S rRNA <=> pseudouridine(2457) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202325", "l": "Recruitment of Gads to LAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130194", "l": "ABL phosphorylates WAVEs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033904", "l": "dextranase activity", "d": ["Catalysis of the endohydrolysis of 1,6-alpha-D-glucosidic linkages in dextran."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44370", "l": "Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide => Cr(6+) + 2 NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375395", "l": "C5a receptor binds C5a anaphylatoxin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614271", "l": "Autocleavage of ADGRG6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9675026", "l": "Formation of the MLL1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49964", "l": "5,10-dihydrophenazine + O2 = H2O2 + phenazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112429", "l": "Formation of FACT complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0008270", "l": "zinc ion binding", "d": ["Binding to a zinc ion (Zn)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25861", "l": "GTP + H2O => 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69113", "l": "glyoxylate + L-2-aminoadipate => 2-oxoadipate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65779", "l": "chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42050", "l": "acetoacetyl-CoA + H(+) + NADH => 3-hydroxybutanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175108", "l": "Target DNA binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39809", "l": "octadecanoate(out) => octadecanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698931", "l": "C Nucleocapsid Assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381087", "l": "Dimerization of PERK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985943", "l": "p-Y701-STAT1 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31116", "l": "ATP + biotin + H(+) => biotinyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666001", "l": "Profilin:G-actin binds MKL1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61586", "l": "5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55359", "l": "11-cis-retinol <=> 13-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48215", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52571", "l": "epitestosterone + UDP-alpha-D-glucuronate <=> epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15367", "l": "3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54236", "l": "1,2-didecanoyl-sn-glycerol + CDP-choline = 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1449687", "l": "Corticosteroids bind to CBG in blood (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050700", "l": "CARD domain binding", "d": ["Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696491", "l": "CNTF binds CNTFR complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694563", "l": "ABHD10 hydrolyses MPAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75297", "l": "chloride(out) + sulfate(in) => chloride(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76416", "l": "Benzene is hydroxylated to phenol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26499", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21803", "l": "all-trans-antheraxanthin + L-ascorbate <=> all-trans-zeaxanthin + H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202966", "l": "Caspase mediated cleavage of HIP-55 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.33", "l": "\"polynucleotide 5'-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5225649", "l": "RBBP7 binds histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56713", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] => H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28821", "l": "5-dehydro-D-gluconate(out) + H(+)(out) => 5-dehydro-D-gluconate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41515", "l": "L-ornithine + NADH + O2 <=> H2O + N(5)-hydroxy-L-ornithine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51778", "l": "deoxycohumulone + diphosphate => 4-prenylphlorisobutanophenone + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103086", "l": "methylthiopentylmalate isomerase activity", "d": ["Catalysis of the reaction: 2-(5'-methylthio)pentylmalate <=> 3-(5'-methylthio)pentylmalate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68197", "l": "1,2-dihexanoylglycerol + tetradecanoyl-CoA => 1,2-dihexanoyl-3-tetradecanoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43183", "l": "cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63651", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40292", "l": "ATP + CoA + tetradecanedioate => AMP + diphosphate + tetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818937", "l": "MEN1 binds MLL1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35883", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035991", "l": "nitric oxide sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of nitric oxide (NO)."]}]}
{"type": "biolink:MolecularActivity", "ic": "56.100061334875598", "identifiers": [{"i": "GO:0016746", "l": "acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62754", "l": "(S)-2-methylbutanoate + H(+) + pravastatin diol lactone => H2O + pravastatin lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645535", "l": "ALPK1 phosphorylates TIFA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76052", "l": "Binding of TFIIIA To type 1 Promoter (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692755", "l": "CDK1 phosphorylates MAPK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72798", "l": "bilirubin-bisglucuronoside(out) <=> bilirubin-bisglucuronoside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51183", "l": "cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990600", "l": "single-stranded DNA endodeoxyribonuclease activator activity", "d": ["Increases the activity of a single-stranded DNA endodeoxyribonuclease activator activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55893", "l": "a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 => a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57063", "l": "2''-O-acetyl-ADP-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15985", "l": "formate + NAD(+) = CO2 + NADH", "d": []}, {"i": "EC:1.17.1.9", "l": "\"formate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374664", "l": "Phosphorylation and activation of Ezrin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602242", "l": "Defective CYP2U1 does not omega-hydroxylate ARA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983152", "l": "Transfer of ubiquitin from E1 to E2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805276", "l": "CDK5 phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25550", "l": "abieta-8(14),12-diene + diphosphate => (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61192", "l": "(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32477", "l": "glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine => glycine + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48153", "l": "ganglioside GD1b(d18:1(4E)/18:0) + H2O => ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25235", "l": "N-acetyl-beta-neuraminate => N-acetyl-alpha-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50231", "l": "FADH2 + O2 + resorcinol <=> benzene-1,2,4-triol + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53192", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19467", "l": "H(+) + NADP(+) + 2 nitrate => NADPH + 2 nitric oxide + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981713", "l": "C4b binds to cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36635", "l": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.282", "l": "\"tRNA(Phe) 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4)]-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61751", "l": "rubusoside + UDP-alpha-D-glucose <=> H(+) + stevioside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32928", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69232", "l": "(Z)-3-hydroxypropyl glucosinolate + H2O = (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45672", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59016", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) = CO2 + cycloeucalenone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952226", "l": "RUNX3 binds the BCL2L11 (BIM) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-606349", "l": "Mis18 complex binds the centromere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869694", "l": "oxPL binds CD14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32430", "l": "(1R,4S)-isodihydrocarvone + A <=> (S)-carvone + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21500", "l": "UDP-alpha-D-glucose = H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}, {"i": "EC:4.2.1.76", "l": "\"UDP-glucose 4,6-dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25965", "l": "(R)-benzoin + NADP(+) => benzil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43293", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39330", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA <=> (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50722", "l": "FMN + H(+) + H2O + methanesulfonate => FMNH2 + methanesulfinate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9708866", "l": "pro-F2R binds vorapaxar (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64694", "l": "2-methylpropanal + H(+) + NADH => isobutanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18316", "l": "(R)-mandelonitrile <=> benzaldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0032397", "l": "activating MHC class I receptor activity", "d": ["Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39439", "l": "(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA = (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700154", "l": "Active ALK binds SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004705", "l": "JUN kinase activity", "d": ["Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39641", "l": "(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28679", "l": "3-demethylubiquinol-8 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729330", "l": "SRPK1/2 phosphorylates nucleoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10070", "l": "4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32772", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate => 2,6-dioxo-6-phenylhexa-3-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30086", "l": "4 Cu(+) + 4 H(+) + O2 <=> 4 Cu(2+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0070746", "l": "interleukin-35 binding", "d": ["Binding to interleukin-35."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30220", "l": "dimethyl sulfoxide + H2O + NAD(+) => dimethyl sulfone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39986", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353313", "l": "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40484", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39914", "l": "(2S,3S)-3-methylphenylalanine + 2-oxoglutarate <=> (3S)-2-oxo-3-phenylbutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018766", "l": "RHOU binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44407", "l": "3-demethylubiquinol-7 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63857", "l": "O2 + tetradecanoate => (2R)-2-hydroperoxytetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53126", "l": "delta-carotene => all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30800", "l": "(3S)-3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205649", "l": "p62 links damaged mitochondria to LC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029473", "l": "Branching and elongation of mother and daughter filaments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42053", "l": "9-cis-retinol + NAD(+) => 9-cis-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34082", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+) <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670156", "l": "PtdIns(4,5)P2 binds WASP, N-WASP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30050", "l": "chloroacetaldehyde + H2O + NAD(+) <=> chloroacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50969", "l": "adenosine(37) in tRNA(Ala) + H(+) + H2O => inosine(37) in tRNA(Ala) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12410", "l": "2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+) => L-lysine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18369", "l": "O2 + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H2O2", "d": []}, {"i": "EC:1.1.3.21", "l": "\"glycerol-3-phosphate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0140034", "l": "methylation-dependent protein binding", "d": ["Binding to a protein upon methylation of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950782", "l": "p-STAT1 binds p-STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003904", "l": "deoxyribodipyrimidine photo-lyase activity", "d": ["Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706977", "l": "6:KPNA2 binds KPNB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31546", "l": "all-trans-zeaxanthin + 2 UDP-alpha-D-glucose <=> 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53928", "l": "a tertiary amine + S-adenosyl-L-methionine = a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004305", "l": "ethanolamine kinase activity", "d": ["Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H+ + phosphoethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949580", "l": "F1Fo ATP synthase dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174963", "l": "NAT1 acetylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047768", "l": "carboxy-cis,cis-muconate cyclase activity", "d": ["Catalysis of the reaction: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35912", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22875", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 <=> CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18547", "l": "glycolaldehyde + pyruvate => 2-dehydro-3-deoxy-L-arabinonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48839", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086058", "l": "voltage-gated calcium channel activity involved in Purkinje myocyte cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an Purkinje myocyte cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48393", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72691", "l": "Formation of the 43S pre-initiation complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173705", "l": "C5b binds C6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033449", "l": "GUU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GUU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866941", "l": "MID1IP1 binds THRSP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005340", "l": "Expression of SOCS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042299", "l": "lupeol synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction is the cyclization of (S)-2,3-epoxysqualene (2,3-oxidosqualene) to lupeol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203611", "l": "N-myristoylation of eNOS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74556", "l": "(S)-malate(out) => (S)-malate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109702", "l": "PDPK1 phosphorylates AKT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102989", "l": "5-pentadecatrienylresorcinol synthase activity", "d": ["Catalysis of the reaction: 3 H+ + 9,12,15-cis-hexadecatrienoyl-CoA + 3 malonyl-CoA(5-) <=> 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + 4 coenzyme A + 4 carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33166", "l": "beta-nicotinamide D-riboside(in) <=> beta-nicotinamide D-riboside(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28551", "l": "acetyl-CoA + anthranilate => CoA + N-acetylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40668", "l": "2-aminoprop-2-enoate => 2-iminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983156", "l": "Polyubiquitination of substrate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353268", "l": "Binding of Pol zeta complex to a DNA template containing lesions (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56730", "l": "4,4-dihydroxy-all-trans-beta-carotene + A + H2O => 4-hydroxy-all-trans-beta-carotene + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014467", "l": "RHOG binds effectors at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26402", "l": "all-trans-10'-apo-beta-carotenal + O2 => (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2318373", "l": "Defective GUSB does not hydrolyse (HA)2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954117", "l": "E2F6:TFDP1 binds EPC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22560", "l": "(3R)-vestitone + NADP(+) = 2'-hydroxyformononetin + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.45", "l": "\"2'-hydroxyisoflavone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391933", "l": "EP3 receptor can bind PGE2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507868", "l": "Aquaporins passively transport water into cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199131", "l": "PVR binds CD226 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879248", "l": "desacetylmycothiol is acetylated to mycothiol using acetyl-CoA (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24664", "l": "2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 = H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357445", "l": "PAK1-3 dimer disassociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174438", "l": "Formation of the Flap Intermediate on the C-strand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20495", "l": "an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65044", "l": "4-cyanobenzyl alcohol + NAD(+) = 4-cyanobenzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866304", "l": "pre-VLDL binds lipids to form VLDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0032135", "l": "DNA insertion or deletion binding", "d": ["Binding to a double-stranded DNA region containing an insertion or a deletion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432946", "l": "PARVB/Affixin interacts with alpha PIX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52714", "l": "2-deoxy-D-ribose 5-phosphate + thymine => dTMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59080", "l": "bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33326", "l": "a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15128", "l": "acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) <=> CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58030", "l": "a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+) => 5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68224", "l": "2-oxoglutarate + H(+) + O2 + prekainate = CO2 + H2O + kainate lactone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11138", "l": "a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33469", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+) => 5-dehydroepisterol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71966", "l": "(R)-2-hydroxyglutarate(out) + 3 Na(+)(out) <=> (R)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14459", "l": "3-propylmalate + CoA + H(+) => glyoxylate + H2O + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044017", "l": "histone H3K27 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54799", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) <=> an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018758", "l": "RHOH binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68476", "l": "a (2R)-2-hydroperoxy fatty acid + H(+) = a fatty aldehyde + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.958976004066542", "identifiers": [{"i": "GO:0022884", "l": "macromolecule transmembrane transporter activity", "d": ["Enables the transfer of a macromolecule from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18787", "l": "AH2 + gibberellin A12 + H(+) => A + gibberellin A12 aldehyde + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654569", "l": "Activated FGFR1 binds FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182594", "l": "Association of INK4 family proteins with CDK4/6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140696", "l": "factor V -> factor Va + factor V activation peptide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1566979", "l": "Laminin-332 degradation by laminin-322 degrading extracellular proteinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641134", "l": "SMURF2 binds AXIN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46198", "l": "7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + pregnenolone + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624800", "l": "CDK1 phosphorylates LBR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696465", "l": "USP45 deubiquitinates ERCC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804379", "l": "PRMT5 binds TTC5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654163", "l": "Activated FGFR4 binds PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72099", "l": "Na(+)(out) + O-acetyl-(R)-carnitine(out) = Na(+)(in) + O-acetyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75358", "l": "H2O + L-mimosine <=> 3-hydroxy-4H-pyrid-4-one + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373342", "l": "CX3CR1 binds CX3CL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71386", "l": "L-asparagine(in) + Na(+)(in) <=> L-asparagine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54298", "l": "diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein] => GTP + L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74049", "l": "L-alanine(out) + L-valine(in) => L-alanine(in) + L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33274", "l": "a triacyl-sn-glycerol + H2O <=> a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22041", "l": "H2O + N-formyl-L-aspartate => formate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9655071", "l": "Transcription of DDIT3 (CHOP, GADD153) in response to heme deficiency (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34382", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose <=> beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14733", "l": "Ag(+)(in) + ATP + H2O = ADP + Ag(+)(out) + H(+) + phosphate", "d": []}, {"i": "EC:7.2.2.15", "l": "\"P-type Ag(+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47451", "l": "(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114683", "l": "Phosphorylation of Platelet Sec-1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64236", "l": "atrochrysone carboxyl-[ACP] + H2O = atrochrysone carboxylate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936563", "l": "ISGylation of DDX58 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51278", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004560", "l": "alpha-L-fucosidase activity", "d": ["Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102936", "l": "gypsogenate-UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenate = gypsogenate-28-beta-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68693", "l": "3'-phosphoadenylyl sulfate + 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(beta-D-glucuronate) => 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49207", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11563", "l": "(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) <=> catechol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10574", "l": "(2E)-butenoyl-CoA => vinylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378975", "l": "Follitropin is a heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047570", "l": "3-oxoadipate enol-lactonase activity", "d": ["Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69152", "l": "Removal of remaining Flap (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093342", "l": "SDC2 multimerises (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033849", "l": "chrysanthemyl diphosphate synthase activity", "d": ["Catalysis of the reaction: 2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30915", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68121", "l": "a 1,2-diacylglycerol + a fatty acyl-CoA => a triacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38524", "l": "1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65613", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54865", "l": "H(+) + NADPH + O2 + sulcatone => 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043522", "l": "leucine zipper domain binding", "d": ["Binding to a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987223", "l": "IL10RB binds TYK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64613", "l": "ATP + L-glutamate + tRNA(Gln) => AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446372", "l": "Association of  PARVA with TESK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39800", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46336", "l": "3-oxochola-4,17-dien-22-oyl-CoA + H2O = 17-hydroxy-3-oxochol-4-en-22-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42629", "l": "S-adenosyl-L-methionine + uridine(747) in 23S rRNA => 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71565", "l": "5-acetylaminomethyl-dUMP in DNA + CoA + H(+) => 5-aminomethyl-dUMP in DNA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47437", "l": "(2E,7Z)-hexadecadienoyl-CoA + H2O => (3S)-hydroxy-(7Z-hexadecenoyl)-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653936", "l": "Formation of Ragulator complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45980", "l": "3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73080", "l": "S-adenosyl-L-methionine + scutellarein => S-adenosyl-L-homocysteine + scutellarein 7-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2250301", "l": "Formation of lysyl-pyrrole cross-links (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382054", "l": "PDGF binds to extracellular matrix proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213200", "l": "Release of endostatin-like peptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55482", "l": "ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44818", "l": "2-demethylmenaquinol-12 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72885", "l": "2 AMP + 2 diphosphate + H(+) + polyporic acid => 2 3-phenylpyruvate + 2 ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28445", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + dodecanoyl-[ACP] <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16234", "l": "(R)-pantoate + NADP(+) => 2-dehydropantoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693012", "l": "TNFSF15 binds TNFRSF25 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71231", "l": "2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50025", "l": "dodecanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71741", "l": "2-oxoadipate(out) + 2-oxoglutarate(in) => 2-oxoadipate(in) + 2-oxoglutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665000", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20592", "l": "glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29838", "l": "D-galactonate(in) + H(+)(in) <=> D-galactonate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45406", "l": "1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395784", "l": "Nascent CMs transform into mature CMs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047292", "l": "trihydroxypterocarpan dimethylallyltransferase activity", "d": ["Catalysis of the reaction: (6AS,11AS)-3,6A,9-trihydroxypterocarpan + dimethylallyl-pyrophosphate = glyceollin + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080042", "l": "ADP-glucose pyrophosphohydrolase activity", "d": ["Catalysis of the reaction: ADP-glucose + H2O = AMP + glucose-1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654625", "l": "Activated FGFR3 binds SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.4.1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902670", "l": "carbon dioxide binding", "d": ["Binding to carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3311014", "l": "SMAD4 MH2 Domain Mutants do not bind phosphorylated SMAD2 and SMAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25464", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + longifolene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25294", "l": "acetaldehyde + H2O + NAD(+) = acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.15", "l": "\"N-sulfoglucosamine-3-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31480", "l": "soyasapogenol A + UDP-alpha-D-glucuronate => H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62364", "l": "FMN-N(5)-peroxide + thymine = (Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12968", "l": "ATP + D-galacturonate <=> 1-phospho-alpha-D-galacturonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59035", "l": "(Z)-24-ethylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46465", "l": "(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33309", "l": "(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein] => (2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877490", "l": "FOXP3 in complex with RUNX1 binds to the TNFRSF18 (GITR) gene intron 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388832", "l": "PI3K binds CD28 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30055", "l": "L-allo-threonine + NADP(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029449", "l": "Phosphorylation of SYK by Src kinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41233", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47541", "l": "7-oxolithocholate + H(+) + NADPH => NADP(+) + ursodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8963915", "l": "1,25(OH)2D binds VDR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351207", "l": "Spermine  => N-acetylated spermine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22179", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426223", "l": "Cation influx mediated by TRPC3/6/7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22829", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + H2O => 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693198", "l": "RHOD binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24851", "l": "3-dehydroshikimate <=> 3,4-dihydroxybenzoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61716", "l": "ATP + D-galactofuranose(out) + H2O = ADP + D-galactofuranose(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.5.2.9", "l": "\"ABC-type D-galactofuranose transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757686", "l": "SERPINA6 binds PREDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55523", "l": "dimethylallyl diphosphate + 3 isopentenyl diphosphate <=> 3 diphosphate + nerylneryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36557", "l": "CoA + H(+) + N-eicosanoylsphinganine => eicosanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709547", "l": "ESTG binds ESR2:chaperone complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13606", "l": "2 L-ascorbate + O2 => 2 H2O + 2 L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23546", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP => a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72264", "l": "chloride(out) + oxalate(in) => chloride(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37737", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75288", "l": "glyoxylate(in) + sulfate(out) => glyoxylate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749253", "l": "Formation of MCM2-7 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28125", "l": "ATP + di-trans,octa-cis-undecaprenol <=> ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67280", "l": "(2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione = (1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.1.-", "l": "\"Sulfurtransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709842", "l": "MAVS binds TOMM70 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67344", "l": "kaempferol 7-O-beta-D-glucoside + malonyl-CoA = CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437118", "l": "GPVI stimulates PI3K beta, gamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684238", "l": "E and N are recruited to the M lattice (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74135", "l": "petunidin + UDP-alpha-D-galactose = petunidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120147", "l": "formylglycine-generating oxidase activity", "d": ["Catalysis of the reaction: A [sulfatase]-L-cysteine + O2 + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64081", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047805", "l": "cytidylate cyclase activity", "d": ["Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56009", "l": "4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27399", "l": "beta-D-glucose + dichloroarcyriaflavin A => 4'-demethylrebeccamycin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53503", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018752", "l": "epsilon-caprolactam lactamase activity", "d": ["Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58652", "l": "rifamycin SV ortho-naphthoquinone carboxamide = rifamycin SV para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65228", "l": "(1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+) = H(+) + NADPH + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952371", "l": "MDM2 binds RUNX3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19388", "l": "UDP-alpha-D-glucose + vomilenine <=> H(+) + raucaffricine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44590", "l": "(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421495", "l": "Synthesis of ALAS2 nascent polypeptide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-170120", "l": "Translocation of Cdc25B to the cytoplasm (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35890", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854303", "l": "TBC1D11 binds RAB6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114558", "l": "Thrombin-activated PARs activate Gq (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40864", "l": "FAD + H(+) + heptadecanoyl-CoA => FADH2 + trans-2-heptadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392295", "l": "Gbeta:gamma recruits PI3K gamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20075", "l": "acetaldehyde + glycine => D-allothreonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74895", "l": "nitric oxide(out) = nitric oxide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866851", "l": "CFTR transits to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22902", "l": "diacetyl + H(+) + NADH => (R)-acetoin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63764", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70672", "l": "N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA => CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013435", "l": "RHOD auto-activates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50419", "l": "L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] <=> H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0052890", "l": "oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin."]}, {"i": "EC:1.3.8.-", "l": "\"With a flavin as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68134", "l": "CoA + tetradecanoate phytyl ester => phytol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29329", "l": "(S)-malate(out) + succinate(in) => (S)-malate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47404", "l": "(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) = 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42064", "l": "ATP + GTP = 2',3'-cGAMP + 2 diphosphate", "d": []}, {"i": "EC:2.7.7.86", "l": "\"cyclic GMP-AMP synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297275", "l": "CD9:Izumo Binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65399", "l": "8-oxo-dATP + H2O <=> 8-oxo-dAMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380780", "l": "Activation of Src (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183072", "l": "EGFR non-clathrin mediated endocytosis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51391", "l": "acetyl-CoA + dopamine <=> CoA + H(+) + N-acetyl-dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70269", "l": "hydrogencarbonate(out) + Na(+)(out) => hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65835", "l": "AH2 + ATP + 2 Co(II)-[dimethylamine-specific corrinoid protein] + H2O <=> A + ADP + 2 Co(I)-[dimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112395", "l": "Abortive termination of elongation after arrest (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15069", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a = chlorophyllide a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672978", "l": "RAF phosphorylates MAP2K dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990594", "l": "L-altrarate dehydratase activity", "d": ["Catalysis of the reaction: L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H2O."]}, {"i": "RHEA:44028", "l": "L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H2O", "d": []}, {"i": "EC:4.2.1.156", "l": "\"L-talarate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37692", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855047", "l": "Hydrolysis of internal thioester in C4b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9710254", "l": "GSDME oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60616", "l": "N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine = ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49292", "l": "D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] = 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.205", "l": "\"protein-N(pi)-phosphohistidine--D-cellobiose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58688", "l": "NADH + O2 + rifamycin SV = H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71532", "l": "guanine(out) => guanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17611", "l": "3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine => L-seryl-[sulfatase] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008677", "l": "2-dehydropantoate 2-reductase activity", "d": ["Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44242", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047602", "l": "acetoacetate decarboxylase activity", "d": ["Catalysis of the reaction: acetoacetate + H+ = acetone + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990932", "l": "5.8S rRNA binding", "d": ["Binding to 5.8S ribosomal RNA, a eukaryotic ribosomal RNA which forms a complex with 28S RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46155", "l": "15-cis-phytoene + a plastoquinone <=> 15,9'-di-cis-phytofluene + a plastoquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990576", "l": "G protein-coupled glucose receptor activity", "d": ["Combining with an extracellular glucose molecule and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31997", "l": "7-epi-sesquithujene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69312", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate = benzyl thiocyanate + sulfate", "d": []}, {"i": "EC:4.8.1.7", "l": "\"phenyl-N-(sulfonatooxy)methanimidothioate sulfolyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43473", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654224", "l": "Activated FGFR3 binds PLCG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854209", "l": "TBC1D10A binds JFC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793933", "l": "Expression of MESP2 in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693598", "l": "ATM phosphorylates NBN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70162", "l": "folate(in) + H(+)(in) <=> folate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448958", "l": "Nuclear translocation of p38 MAPK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67326", "l": "(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine => acetyl-CoA + ATP + 11 H(+) + L-serine + 7 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39541", "l": "(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+) => (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14864", "l": "(S)-dihydroorotate + NADP(+) <=> H(+) + NADPH + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42164", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 = (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25796", "l": "2-oxoglutarate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707659", "l": "Hemes:LY96 activates TLR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58136", "l": "acetate + ATP + H(+) = acetyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32556", "l": "(2E)-geranyl diphosphate + H2O => (R)-alpha-terpineol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60308", "l": "L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.357", "l": "\"[histone H3]-lysine(36) N-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43651", "l": "H(+) + hexadecanoyl-CoA + malonyl-[ACP] <=> 3-oxooctadecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785898", "l": "IL4R binds JAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651789", "l": "LIG1 bound to POLB ligates SSB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.19", "l": "\"glycine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088130", "l": "PLK1 binds FOXM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612085", "l": "SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654224", "l": "Activated FGFR3 binds PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68256", "l": "L-cystine(in) + Na(+)(in) = L-cystine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10694", "l": "H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone => 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74782", "l": "laricitrin + S-adenosyl-L-methionine <=> 3,3'-O-dimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32630", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69005", "l": "Cdc6 protein is phosphorylated by CDK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28872", "l": "D-fructuronate(in) + H(+)(in) => D-fructuronate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987223", "l": "IL10RB binds TYK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26067", "l": "ATP + hygromycin B <=> 4-O-phosphohygromycin B + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23951", "l": "4-hydroxybutanoate + NAD(+) <=> H(+) + NADH + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-976768", "l": "Factor H binds to C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42190", "l": "5alpha-androstan-3,17-dione + H(+) + NADH => 3beta-hydroxy-5alpha-androstan-17-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65914", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine => 3-hydroxy-L-kynurenine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809010", "l": "COPI vesicle uncoating (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47671", "l": "H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943279", "l": "GGT dimers hydrolyse GSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450488", "l": "BRF1 Complex recruits RNA degradation activities (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601929", "l": "Unknown nuclease cleaves cleaved transposon RNA in 6xMeR-PIWIL2:cleaved transposon RNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66716", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate = (2S)-3-sulfolactaldehyde + D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871266", "l": "YAP1 binds TEAD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3341294", "l": "Superoxide reduces cytochrome c (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683801", "l": "CHEK2 phosphorylates BRCA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66532", "l": "ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] = diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015503", "l": "glutathione-regulated potassium exporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70005", "l": "cathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-oxocampestanol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54420", "l": "3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)", "d": []}, {"i": "EC:3.1.4.59", "l": "\"cyclic-di-AMP phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75130", "l": "neopinone <=> codeinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68025", "l": "H2O + presqualene monophosphate => phosphate + presqualene alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451309", "l": "Edited Kainate Receptor binds glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621918", "l": "Defective GCK does not phosphorylate Glc to form G6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0004190", "l": "aspartic-type endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67842", "l": "a lipid IVA + ADP + H(+) => a lipid A disaccharide + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0052706", "l": "histidine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27917", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38943", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031858", "l": "pituitary adenylate cyclase-activating polypeptide receptor binding", "d": ["Binding to a pituitary adenylate cyclase-activating polypeptide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29339", "l": "(S)-malate(in) + 2 H(+)(in) = (S)-malate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0008353", "l": "RNA polymerase II CTD heptapeptide repeat kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53076", "l": "cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine = 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0016004", "l": "phospholipase activator activity", "d": ["Binds to and increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75305", "l": "3'cADPR + H(+) + nicotinamide => NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009044", "l": "xylan 1,4-beta-xylosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043907", "l": "Cys-tRNA(Pro) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Cys-tRNA(Pro)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196026", "l": "Dab2 is recruited to the junctional plaques (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42598", "l": "prostaglandin G2 => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322429", "l": "XIAP monoubiquinates TLE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15693", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 = (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034835", "l": "2-mercaptobenzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: 2-mercaptobenzothiazole + 1/2 O2 = 6-hydroxy-2-mercaptobenzothiazole."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39079", "l": "(3S)-hydroxydodecanedioyl-CoA + NAD(+) = 3-oxododecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42896", "l": "L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.297", "l": "\"peptide chain release factor N(5)-glutamine methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672083", "l": "KTN1 binds Kinesin-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10243", "l": "a 2,3-saturated acyl-[ACP] + NAD(+) <=> a (2E)-enoyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59238", "l": "diphosphate + isoelisabethatriene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042021", "l": "granulocyte macrophage colony-stimulating factor complex binding", "d": ["Binding to a granulocyte macrophage colony-stimulating factor complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48241", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b => CMP + ganglioside GT1b + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48305", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114558", "l": "Thrombin-activated PARs activate Gq (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55048", "l": "(3E,5Z)-dodecadienoyl-CoA + H2O = (3E,5Z)-dodecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46967", "l": "lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802924", "l": "RAF is phosphorylated downstream of oncogenic RAS  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30891", "l": "O-acetyl-L-serine + thiosulfate = acetate + H(+) + S-sulfo-L-cysteine", "d": []}, {"i": "EC:2.5.1.144", "l": "\"S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33169", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol => 2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30172", "l": "hexadecanoyl-[ACP] + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73012", "l": "L-leucine(in) => L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58802", "l": "5'-pApG-3' + H(+) => 3',3'-cGAMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28497", "l": "a menaquinone + dimethyl sulfide + H2O <=> a menaquinol + dimethyl sulfoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11505", "l": "6-demethylsterigmatocystin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + sterigmatocystin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592387", "l": "Fibulin binds elastic fibres (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70695", "l": "chloride(out) + glycine(out) + 3 Na(+)(out) = chloride(in) + glycine(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000247", "l": "C-8 sterol isomerase activity", "d": ["Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017017", "l": "MAP kinase tyrosine/serine/threonine phosphatase activity", "d": ["Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669012", "l": "EDA binds EDAR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031849", "l": "olfactory receptor binding", "d": ["Binding to an olfactory receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047970", "l": "guanidinoacetase activity", "d": ["Catalysis of the reaction: guanidinoacetate + H2O = glycine + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852010", "l": "BTNL2 binds activated T cells surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67274", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + 9-hydroxy-(10E,12Z)-octadecadienoate + H(+) => 1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40456", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA => (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12455", "l": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39934", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11389", "l": "an 11beta-hydroxysteroid + NADP(+) => an 11-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102704", "l": "GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose(2-) + a (mannosyl)2-(N-acetylglucosaminyl)2-diphosphodolichol <=> H+ + GDP(3-) + a (mannosyl)3-(N-acetylglucosaminyl)2-diphosphodolichol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75564", "l": "cyathadiol + O2 + reduced [NADPH--hemoprotein reductase] => cyathatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110011", "l": "Binding of Grb10 to the insulin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48244", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 = CMP + ganglioside GM1b + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31110", "l": "3-phenylpyruvate + O2 <=> (2-hydroxyphenyl)acetate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130194", "l": "ABL phosphorylates WAVEs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56521", "l": "Fe-coproporphyrin III + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864595", "l": "TFAP2B homodimer binds YEATS4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57326", "l": "CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein] => acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610722", "l": "CK1 phosphorylates p-GLI3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0038100", "l": "nodal binding", "d": ["Binding to a nodal protein, a member of the transforming growth factor-beta superfamily."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51633", "l": "all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73135", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine = 4',7-dihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73687", "l": "dAMP(out) + phosphate(in) = dAMP(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33516", "l": "2 5,6-dihydroxyindole + O2 => 2 H2O + 2 indole-5,6-quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873919", "l": "Phosphorylation of JAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672957", "l": "PP2A dephosphorylates KSR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5227009", "l": "ABCF1 binds EIF2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692755", "l": "CDK1 phosphorylates MAPK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55463", "l": "11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204863", "l": "Interaction of Tie2 with Ang2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173636", "l": "Formation of classic pathway C5 convertase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60660", "l": "1,4-benzoquinone + H(+) + NADH = hydroquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140443", "l": "mitochondrion-plasma membrane adaptor activity", "d": ["The binding activity of a molecule that brings together a mitochondrion and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52562", "l": "3-dehydro-D-erythronate => 2-dehydro-D-erythronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.093101469280398", "identifiers": [{"i": "GO:0009055", "l": "electron transfer activity", "d": ["Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67809", "l": "L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57510", "l": "(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate => H2O + NADP(+) + staphylopine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299481", "l": "TIMM9:TIMM10 binds hydrophobic proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9752977", "l": "RTP1S and RTP2 bind underrepresented Olfactory Receptors (uORs) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54560", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP = a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220971", "l": "CDK8 phosphorylates NICD1 PEST domain mutants  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72445", "l": "(E)-feruloyl-CoA + AMP + H(+) => (E)-feruloyl-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34302", "l": "2'-deamino-2'-hydroxyneamine + 2-oxoglutarate <=> 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48253", "l": "ganglioside GD2 + UDP-alpha-D-galactose => ganglioside GD1b + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33961", "l": "6'''-deamino-6'''-oxoneomycin C + L-glutamate => 2-oxoglutarate + neomycin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471322", "l": "Beta-defensins are secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32906", "l": "calciol + O2 + reduced [NADPH--hemoprotein reductase] <=> calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33890", "l": "(-)-secoisolariciresinol + 2 NAD(+) <=> (-)-matairesinol + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102325", "l": "2,2',3-trihydroxybiphenyl monooxygenase activity", "d": ["Catalysis of the reaction: biphenyl-2,2',3-triol + O2 + NADH + H+ <=> 2,2',3,3'-tetrahydroxybiphenyl + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11602", "l": "ADP + CDP => ATP + CMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44340", "l": "(S)-2,3-diaminopropanoate + ATP + fumarate = AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate", "d": []}, {"i": "EC:6.3.2.46", "l": "\"fumarate--(S)-2,3-diaminopropanoate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928615", "l": "EFNBs bind SFKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47038", "l": "pseudouridine in 5S rRNA => uridine in 5S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54498", "l": "diphosphate + ent-atiserene => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23680", "l": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.15", "l": "\"nucleoside-triphosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51898", "l": "acetate + spermine => H2O + N(1)-acetylspermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56561", "l": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose => [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55468", "l": "11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] = 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236970", "l": "Proteasomal clevage of exogenous antigen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24252", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57901", "l": "2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 => adenosine in U6 snRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75940", "l": "4-aminobutanoate + L-arginine => 4-guanidinobutanoate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158399", "l": "kallikrein binds SERPING1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55487", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295599", "l": "SPRY2 translocates to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37142", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate <=> 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44096", "l": "decan-1-ol + hexadecanoyl-CoA = CoA + decanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39917", "l": "1-O-alkyl-sn-glycerol + phosphate => 1-O-alkyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67545", "l": "(9Z)-tetradecenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54360", "l": "4-methyl-2-oxopentanoate + H(+) = 3-methylbutanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24161", "l": "D-galactose + O2 => D-galacto-hexodialdose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103062", "l": "cis-keto-C60-meroacyl-AMP ligase activity", "d": ["Catalysis of the reaction: ATP(4-) + H2O + a cis-keto-C60-meroacyl-[acp] <=> diphosphoric acid + a cis-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50537", "l": "prostaglandin E2 => H2O + prostaglandin A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39001", "l": "a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine => a 1-acyl-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.35", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448629", "l": "IL33 binds IL1RL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2214351", "l": "PLK1 phosphorylates GORASP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672011", "l": "p-AMPK:AMP binds the ULK complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0098918", "l": "structural constituent of synapse", "d": ["The action of a molecule that contributes to the structural integrity of a synapse."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33164", "l": "beta-nicotinamide D-riboside(in) => beta-nicotinamide D-riboside(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-593685", "l": "Netrin-4 binds DCC/UNC5A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73551", "l": "GDP(out) + UTP(in) = GDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67027", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466861", "l": "Defective RDH12 does not reduce atRAL to atROL and causes LCA13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114256", "l": "CYCS:APAF1 binds procaspase-9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72832", "l": "3',3'-cGAMP + H2O => G[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003914", "l": "DNA (6-4) photolyase activity", "d": ["Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159733", "l": "Furin cleaves pro-factor X to factor X (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444433", "l": "Cho transports from the extracellular space to the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75189", "l": "2,5-dihydroxybenzoate + CoA + H(+) => 2,5-dihydroxybenzoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183126", "l": "Factor B binds to surface-associated C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9704248", "l": "CHRM4 binds CHRM4 antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56820", "l": "AH2 + cyclooctat-9-en-7-ol + O2 = A + cyclooctat-9-ene-5,7-diol + H2O", "d": []}, {"i": "EC:1.14.99.61", "l": "\"cyclooctat-9-en-7-ol 5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629189", "l": "TP53 stimulates expression of SESN1,2,3 genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805479", "l": "TP53RK phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57747", "l": "[protein]-disulfide + phylloquinol <=> [protein]-dithiol + phylloquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62284", "l": "2 ATP + L-proline + L-tryptophan + NADPH = (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240957", "l": "Formation of PRC2-EZH2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004577", "l": "N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39245", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+) => (11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202721", "l": "JAM2 binds JAM3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42911", "l": "S-adenosyl-L-methionine + uridine(1939) in 23S rRNA <=> 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55409", "l": "[phosphate](n) + CTP => [phosphate](n+1) + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50878", "l": "a hydroxy polyunsaturated fatty acid + H2O + NADP(+) => a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196964", "l": "RFK:Mg2+ phosphorylates RIB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22138", "l": "chlorophyllide b + 2 H2O + NADP(+) => 7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40026", "l": "9alpha-copalyl diphosphate + H2O <=> diphosphate + syn-copalol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015024", "l": "glucuronate-2-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2134506", "l": "TGFBR1 is recruited to tight junctions by PARD6A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36630", "l": "2-hydroxytetracosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602458", "l": "Activation of proMMP10 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75671", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate = 14,15-epoxy-12-hydroxy-(10E,17Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-179421", "l": "Degradation of multiubiquitinated Nek2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41722", "l": "(9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033453", "l": "GCU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GCU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9718379", "l": "GNRHR binds chemical antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0034481", "l": "chondroitin sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102844", "l": "1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity (SN2-16:2 forming)", "d": ["Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40942", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH <=> 1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21917", "l": "an aliphatic amine + 2 Fe(III)-[cytochrome c550] + H2O => an aldehyde + 2 Fe(II)-[cytochrome c550] + 2 H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61343", "l": "(S)-methylmalonyl-CoA + H(+) <=> CO2 + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2530429", "l": "Formation of soluble VTN:C5b-C9  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052748", "l": "baicalin beta-D-glucuronidase activity", "d": ["Catalysis of the reaction: baicalin + H2O = baicalein + D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45758", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine => (6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20890", "l": "3-hydroxy-2-methylpropanoate + CoA + H(+) => 3-hydroxy-2-methylpropanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047591", "l": "5-hydroxypentanoate CoA-transferase activity", "d": ["Catalysis of the reaction: 5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13520", "l": "ATP + dTMP <=> ADP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097678", "l": "SOCS family protein binding", "d": ["Binding to a member of the suppressor of cytokine signaling (SOCS) family of proteins. SOCS represent an important mechanism to extinguish cytokine and growth factor receptor signaling. Individual SOCS proteins are typically induced by specific cytokines and growth factors, thereby generating a negative feedback loop. SOCS proteins have important functions in development and homeostasis, and in disease, particularly tumor suppression and anti-inflammatory functions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70633", "l": "2''-O-decanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-decanoyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66486", "l": "16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP => 16alpha-hydroxygypsogenate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27894", "l": "3'-CMP + H2O = cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69116", "l": "Formation of Okazaki fragments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35747", "l": "(2E,6E)-farnesyl diphosphate = 7-epizingiberene + diphosphate", "d": []}, {"i": "EC:4.2.3.142", "l": "\"7-epizingiberene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61267", "l": "H2O + L-alanine + O2 <=> H2O2 + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75177", "l": "dADP + H(+) + NADP(+) => dATP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33266", "l": "L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47974", "l": "dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018550", "l": "tetrachloro-p-hydroquinone reductive dehalogenase activity", "d": ["Catalysis of the reaction: 2,3,5,6-tetrachlorohydroquinone + 2 glutathione = 2,3,6-trichlorohydroquinone + glutathione disulfide + HCl."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12002", "l": "CO2 + NADPH => formate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114544", "l": "p115-RhoGEF activation of RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693243", "l": "RHOD translocates to the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483087", "l": "PI is exchanged with PC by PITPNB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341072", "l": "SUMOylation of RARA with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32068", "l": "8-oxoguanine + H(+) + H2O => NH4(+) + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-176318", "l": "Loading of claspin onto DNA during replication origin firing (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374723", "l": "Nociceptin receptor binds to nociceptin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60142", "l": "3-oxotetradecanoyl-CoA + CO2 + CoA => dodecanoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015439", "l": "ABC-type heme transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24069", "l": "cyclohexanone + H(+) + NADPH + O2 => H2O + hexano-6-lactone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20750", "l": "CO2 + deacetoxycephalosporin C + H2O + succinate => 2-oxoglutarate + O2 + penicillin N", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34714", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine <=> 15-methylhexadecasphing-4-enine + a fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42084", "l": "9-cis-retinal + H2O + NAD(+) = 9-cis-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40618", "l": "H2O + tridecanoylglycerol <=> 2,3-didecanoyl-sn-glycerol + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937656", "l": "IL10 negatively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39921", "l": "1-O-(alk-1-enyl)-sn-glycerol + phosphate => 1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668605", "l": "RAC2:GTP binds NOX2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42908", "l": "S-adenosyl-L-methionine + uridine(1939) in 23S rRNA = 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.190", "l": "\"23S rRNA (uracil(1939)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629918", "l": "NEIL1 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64766", "l": "2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol => S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803890", "l": "SFN dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.28", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090585", "l": "protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + L-ascorbate(out) = protein cysteine + L-ascorbate-6-phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25197", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O = 5-amino-6-(D-ribitylamino)uracil + phosphate", "d": []}, {"i": "EC:3.1.3.104", "l": "\"5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49197", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol => 25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18593", "l": "sphinganine 1-phosphate = hexadecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65879", "l": "5alpha-androst-1-ene-3,17-dione + H2O <=> 1-hydroxy-5alpha-androstan-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33921", "l": "24,25-dihydrolanosterol + NADP(+) => H(+) + lanosterol + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371435", "l": "Constitutive phosphorylation by GSK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27339", "l": "15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin] => 2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033425", "l": "CAU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CAU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15734", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73252", "l": "cirsimaritin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50157", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624272", "l": "MMPs cleave HB-EGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70736", "l": "chloride(out) + glycine betaine(out) + 2 Na(+)(out) => chloride(in) + glycine betaine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12055", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + trichodiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66425", "l": "ATP + H2O + leukotriene B4(in) => ADP + H(+) + leukotriene B4(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018523", "l": "quinoline 2-oxidoreductase activity", "d": ["Catalysis of the reaction: quinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33005", "l": "(+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10881", "l": "7-methylxanthosine + H2O => 7-methylxanthine + D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69240", "l": "glucoraphanin + H2O = (Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140775", "l": "actin filament debranching activity", "d": ["Binding to an actin filament and promoting the dissociation of an actin filament branch."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18339", "l": "H2O + psi-UMP => D-ribose 5-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69127", "l": "glyoxylate + L-tryptophan <=> glycine + indole-3-pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688786", "l": "ATXN3 binds RAD23 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247939", "l": "CysGly translocates from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46160", "l": "a quinone + H(+) + NADH = a quinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21743", "l": "2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol <=> [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047981", "l": "histidine N-acetyltransferase activity", "d": ["Catalysis of the reaction: L-histidine + acetyl-CoA = N(alpha)-acetyl-L-histidine + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34108", "l": "glycine + H(+) + hexadecanoyl-CoA => 1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11380", "l": "2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2 = [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.72", "l": "\"[2-(trimethylamino)ethyl]phosphonate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428917", "l": "G13 activation by TP receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3785768", "l": "MRN complex binds DNA double strand breaks (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57258", "l": "GTP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18864", "l": "a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine <=> a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31283", "l": "FAD + H(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75538", "l": "FMNH2 + N-acetyl-S-methyl-L-cysteine + O2 <=> (R)-N-acetyl-S-methyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74856", "l": "dopamine + pyruvate => (R)-salsolinol-1-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54738", "l": "2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine => N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58712", "l": "NADH + O2 + rifampicin = H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65230", "l": "H(+) + NADPH + naphthalene-1,2-diol => (1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13265", "l": "1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine", "d": []}, {"i": "EC:2.1.4.2", "l": "\"scyllo-inosamine-4-phosphate amidinotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425861", "l": "Activation of Protein Kinase C novel isoforms (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72242", "l": "estrone 3-sulfate(out) + L-glutamate(in) <=> estrone 3-sulfate(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70141", "l": "6alpha-hydroxy-28-nortyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24597", "l": "acetyl-CoA + L-histidine => CoA + H(+) + N(alpha)-acetyl-L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854222", "l": "TBC1D3 associates with RAB5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046180", "l": "KSPG is secreted from the cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52974", "l": "a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin] => a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426032", "l": "DAG is metabolized by DAGL to 2-AG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46040", "l": "2'-deoxycytidine + ATP = ADP + dCMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43724", "l": "(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.128", "l": "\"farnesoate epoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55089", "l": "eburicol + S-adenosyl-L-methionine => (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0004693", "l": "cyclin-dependent protein serine/threonine kinase activity", "d": ["Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47398", "l": "an aliphatic alcohol + H(+) + octadecanoate => H2O + octadecanoate ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-532549", "l": "MPI isomerises Fru6P to Man6P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73913", "l": "ADP + H(+) + psilocybin => ATP + psilocin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373724", "l": "Nephrin binds NCK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58020", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = eupatolide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32885", "l": "(+)-artemisinic aldehyde + H(+) + NADPH => (11R)-dihydroartemisinic aldehyde + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68143", "l": "2,5-hexanedione + 2 H(+) + 2 NADPH <=> (2R,5R)-hexanediol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63704", "l": "mycophenolate + UDP-alpha-D-glucuronate = H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14791", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034602", "l": "oxoglutarate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035979", "l": "histone H2AXS139 kinase activity", "d": ["Catalysis of the reaction: histone H2AX-serine (position 139) + ATP = histone H2AX-phosphoserine (position 139) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 139 of histone variant H2AX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42442", "l": "H(+) + iminosuccinate + NADH => L-aspartate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75206", "l": "alpha,alpha-trehalose(out) + ATP + H2O <=> ADP + alpha,alpha-trehalose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64306", "l": "1-phenylpropan-1-one + L-alanine => 1-phenylpropylamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947535", "l": "Cyclisation of GTP to precursor Z (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36845", "l": "3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA => (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799431", "l": "TP53 binds HIPK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018491", "l": "2-oxobutyrate synthase activity", "d": ["Catalysis of the reaction: 2-oxobutanoate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55122", "l": "(3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+) => 4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48853", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 => 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30313", "l": "formaldehyde + H2O + NAD(+) + xanthine => 7-methylxanthine + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31479", "l": "soyasapogenol A + UDP-alpha-D-glucuronate = H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25554", "l": "diphosphate + stemar-13-ene => 9alpha-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40395", "l": "1,2-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70274", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate <=> 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32697", "l": "(-)-car-3-ene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32336", "l": "(1S,2S,4R)-endo-fenchol + NADP(+) => (1S,4R)-fenchone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61465", "l": "a cytidine in mRNA + S-adenosyl-L-methionine => a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.46", "l": "\"memapsin 2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19141", "l": "all-trans-retinol = 11-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62318", "l": "1-O-salicyl-beta-D-glucose + UDP => salicylate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.135", "l": "\"galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8873929", "l": "Casein kinase II phosphorylates STARD10 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109702", "l": "PDPK1 phosphorylates AKT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30575", "l": "3 menaquinone-8 + protoporphyrinogen IX = 3 menaquinol-8 + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695828", "l": "FLT3 binds type I TKI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390846", "l": "D2D3,4 bind to DA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15602", "l": "(E)-cinnamoyl-CoA + (R)-3-phenyllactate => (E)-cinnamate + (R)-3-phenyllactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0035014", "l": "phosphatidylinositol 3-kinase regulator activity", "d": ["Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53897", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990583", "l": "phospholipase D activator activity", "d": ["Binds to and increases the activity of the enzyme phospholipase D."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692376", "l": "BCL2 binds BCL2 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47056", "l": "4alpha-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47730", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+) => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26021", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate => beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75951", "l": "2-oxoglutarate + O2 + oripavine = CO2 + formaldehyde + neomorphinone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858270", "l": "HILPDA binds lipid droplets (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35534", "l": "cyclo(L-phenylalanyl-L-leucyl) + 2 O2 <=> albonoursin + 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.481603666032214", "identifiers": [{"i": "GO:1901682", "l": "sulfur compound transmembrane transporter activity", "d": ["Enables the transfer of a sulfur compound from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417908", "l": "P2RY1 binds ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49276", "l": "CTP + phytyl phosphate = CDP + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786155", "l": "POLN binds ICL-DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033712", "l": "1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity", "d": ["Catalysis of the reaction: 1,5-anhydro-D-mannitol + NADP+ = 1,5-anhydro-D-fructose + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58530", "l": "(16R)-deshydroxymethyl-stemmadenine + formate + NADP(+) => 15alpha-stemmadenine intermediate I + H2O + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16220", "l": "H2O + L-arabinono-1,4-lactone <=> H(+) + L-arabinonate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0016663", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces oxygen."]}, {"i": "EC:1.7.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43573", "l": "A + D-arginine + H2O => 5-guanidino-2-oxopentanoate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0003725", "l": "double-stranded RNA binding", "d": ["Binding to double-stranded RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665704", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190245", "l": "FGFR1b binds to FGF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20697", "l": "2 H(+) + 2 superoxide => H2O2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33881", "l": "3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH => 2-deoxy-scyllo-inosamine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37431", "l": "12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37125", "l": "CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine => sphing-4-enine + tetracosenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40428", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008692", "l": "3-hydroxybutyryl-CoA epimerase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40525", "l": "a quinol + fumarate => a quinone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67007", "l": "a 5'-end triphospho-ribonucleoside in mRNA + H2O <=> a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018538", "l": "DLGAP5 gene transcription is stimulated by NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54455", "l": "a 5,6-dihydrouridine in tRNA + NAD(+) <=> a uridine in tRNA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0103012", "l": "ferredoxin-thioredoxin reductase activity", "d": ["Catalysis of the reaction: 2 H+ + 2 a reduced ferredoxin + an oxidized thioredoxin = 2 an oxidized ferredoxin + a reduced thioredoxin, involving a 4Fe-4S cluster and an adjacent active-site disulfide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28576", "l": "H(+)(out) + sulfate(out) => H(+)(in) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19555", "l": "indole + NH4(+) + pyruvate => H2O + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15340", "l": "H2O + phenylglyoxylyl-CoA <=> CoA + H(+) + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047885", "l": "farnesol 2-isomerase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesol = 2-cis,6-trans-farnesol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32390", "l": "dihydrocarveol + NAD(+) <=> dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52448", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate = 16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102220", "l": "hydrogenase activity (NAD+, ferredoxin)", "d": ["Catalysis of the reaction: 2 dihydrogen + NAD + 2 an oxidized ferredoxin = NADH + 3 H+ + 2 a reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10689", "l": "H2O + streptomycin 6-phosphate => phosphate + streptomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034590", "l": "L-hydroxyproline transmembrane transporter activity", "d": ["Enables the transfer of L-hydroxyproline from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-6784213", "l": "Unknown hydroxyproline carrier transports cytosolic HPRO into the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685296", "l": "GATA6 binds SFTPA genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24409", "l": "adenosine + H(+) + H2O => inosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705082", "l": "SARS-CoV-2 nsp13 binds TBK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14181", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.8", "l": "\"trimethyllysine dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37339", "l": "3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O = (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25518", "l": "CoA + H(+) + O-acyltropine => an acyl-CoA + tropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17139", "l": "thromboxane A2 => prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202721", "l": "JAM2 binds JAM3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093329", "l": "EFNBs bind SDCBP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12638", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52899", "l": "2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin <=> 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41490", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28003", "l": "beta-D-fructose 6-phosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65448", "l": "butanoyl-CoA + ethanol = CoA + ethyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865498", "l": "KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45877", "l": "2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63124", "l": "H2O + N-octadecanoyl ethanolamine = ethanolamine + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57234", "l": "N(2)-(1-hydroxy-2-oxopropyl)-GDP => GDP + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785594", "l": "FANCD2 binds FANCI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043912", "l": "D-lysine oxidase activity", "d": ["Catalysis of the reaction: D-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170001", "l": "ergothioneine transmembrane transporter activity", "d": ["Enables the transfer of ergothioneine from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20206", "l": "methylazoxymethanol + UDP-alpha-D-glucose => cycasin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10411", "l": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA <=> 3-oxopristanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004582", "l": "dolichyl-phosphate beta-D-mannosyltransferase activity", "d": ["Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080095", "l": "phosphatidylethanolamine-sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: a phosphatidylethanolamine + a sterol = a sterol ester + a lysophosphatidylethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73184", "l": "ADP(in) + FAD(out) => ADP(out) + FAD(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042937", "l": "tripeptide transmembrane transporter activity", "d": ["Enables the transfer of a tripeptide, a compound containing three amino acids linked together by peptide bonds, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2090079", "l": "GLB1 hydrolyses linker chain(2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031727", "l": "CCR2 chemokine receptor binding", "d": ["Binding to a CCR2 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27673", "l": "1D-myo-inositol 1-phosphate + H2O <=> myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.144", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858489", "l": "ppDVL binds DAAM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64219", "l": "2-carboxy-L-lyxonate + H(+) <=> CO2 + L-lyxonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38706", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.2", "l": "\"glutaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674140", "l": "PAQR3 binds inactive RAFs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41736", "l": "3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) = adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25258", "l": "N-acetyl-D-glucosamine 6-phosphate => N-acetyl-D-mannosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18103", "l": "3-ethylcatechol + H(+) + NADH => cis-1,2-dihydro-3-ethylcatechol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44883", "l": "ATP + L-threonyl-[receptor-protein] <=> ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58380", "l": "NADP(+) + nonan-1-ol = H(+) + NADPH + nonanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75456", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693356", "l": "CEMIP hydrolyses HA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000310", "l": "AURKA phosphorylates PLK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167097", "l": "HIV Promoter Opening: First Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39626", "l": "3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33769", "l": "a (2E)-enoyl-CoA + H2O => a 3-hydroxy-fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11044", "l": "a haloacetate + H2O = a halide anion + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19389", "l": "(E)-ferulate + ATP + CoA = (E)-feruloyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47851", "l": "2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) <=> CO2 + diphosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.77", "l": "\"oleate 10S-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45513", "l": "phycocyanobilin-L-cysteinyl(155)-[C-phycocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[C-phycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47319", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59217", "l": "(indol-3-yl)acetate + H(+) => CO2 + skatole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944457", "l": "MAF1 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27293", "l": "A + formate + H(+) <=> AH2 + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30965", "l": "7,7',9,9'-tetra-cis-lycopene + a quinol => 7,9,9'-tri-cis-neurosporene + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951966", "l": "EP300 acetylates RUNX3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25111", "l": "ATP + pyridoxine <=> ADP + H(+) + pyridoxine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20546", "l": "H(+) + L-kynurenine + NADPH + O2 => 3-hydroxy-L-kynurenine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382056", "l": "Crk binds to the active PDGF receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50299", "l": "N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857555", "l": "EGFR phosphorylates GPNMB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63340", "l": "ATP + L-amino acyl-L-seryl-[protein] = (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48557", "l": "4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) => 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67048", "l": "AH2 + chermesin D + O2 = A + asnovolin I + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39758", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948066", "l": "K63polyUb-IRAK1 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10828", "l": "anthranilate + ATP + CoA = AMP + anthraniloyl-CoA + diphosphate", "d": []}, {"i": "EC:6.2.1.32", "l": "\"anthranilate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62546", "l": "dihydroouabagenin + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 3 H(+) + ouabagenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53343", "l": "5,6-dihydrouridine(20) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70256", "l": "1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol => cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781953", "l": "YOD1 binds VCP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32326", "l": "ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38035", "l": "(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate = (4Z)-2-oxohept-4-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39682", "l": "(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57319", "l": "ATP + cytidine 5'-diphosphoramidate <=> ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634391", "l": "SHC1 binds phosphorylated ERBB2 homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17841", "l": "trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP", "d": []}, {"i": "EC:2.4.1.229", "l": "\"[Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607751", "l": "TRAF6 oligomerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9641111", "l": "Parkin transfers Ub to misfolded proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53071", "l": "4-methoxyestrone + UDP-alpha-D-glucuronate <=> 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73952", "l": "(2E,6E)-farnesyl diphosphate => beta-maaliene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390593", "l": "ATP Hydrolysis By Myosin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264458", "l": "Proteasome mediated degradation of COP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10621", "l": "(E)-cinnamaldehyde + CoA + NADP(+) => (E)-cinnamoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390929", "l": "HTR1 and 5A receptors can bind serotonin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013009", "l": "RHOA binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45050", "l": "acetate + NH4(+) => acetamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17857", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40289", "l": "AMP + decanedioyl-CoA + diphosphate => ATP + CoA + decanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862380", "l": "HSD17B13 binds lipid droplets (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33007", "l": "(+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22282", "l": "H(+) + puromycin + S-adenosyl-L-homocysteine => O-demethylpuromycin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60396", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O = Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28385", "l": "H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine <=> D-glucose 6-phosphate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682709", "l": "LGI4 binds ADAM22,23,11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10247", "l": "4-fumarylacetoacetate + H2O <=> acetoacetate + fumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49792", "l": "eicosanoyl-CoA + glycine = CoA + H(+) + N-eicosanoylglycinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193656", "l": "p75NTR interacts with RIP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19096", "l": "2 H(+) + siroheme <=> 12,18-didecarboxysiroheme + 2 CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27648", "l": "alpha-D-ribose 1-phosphate + hypoxanthine => inosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28324", "l": "UDP + wogonin 7-O-beta-D-glucuronate => UDP-alpha-D-glucuronate + wogonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12629", "l": "2-oxoglutarate + L-hyoscyamine + O2 = (6S)-6-hydroxyhyoscyamine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.11", "l": "\"hyoscyamine (6S)-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15532", "l": "bis(2-ethylhexyl)phthalate + H2O <=> 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41581", "l": "5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate => 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.-", "l": "\"Site specific endodeoxyribonucleases: cleavage is sequence specific\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.-.-", "l": "\"Acting on the CH-CH group of donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1247960", "l": "Activation of p38 MAPK (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034923", "l": "phenanthrene-4,5-dicarboxylate decarboxylase activity", "d": ["Catalysis of the reaction: phenanthrene-4,5-dicarboxylate + H+ = phenanthrene-4-carboxylate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25157", "l": "(R)-4'-phosphopantothenate + ATP + L-cysteine => AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70763", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858346", "l": "AMHR2 binds AMH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73915", "l": "acetyl-CoA + 4 H(+) + 6 malonyl-CoA = 2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + 6 CO2 + 7 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928591", "l": "EPH:EFN tetramers oligomerise (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74733", "l": "Insulin receptor de-phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635839", "l": "ULK3:SUFU dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54286", "l": "H(+) + N-octadecanoylsphing-4-enine + phosphocholine => H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15854", "l": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) => 17alpha-hydroxyprogesterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18871", "l": "ADP + H(+) + L-xylulose 5-phosphate => ATP + L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112396", "l": "Separation of elongating transcript from template (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36039", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102040", "l": "fumarate reductase (menaquinone)", "d": ["Catalysis of the reaction: fumarate + a menaquinol = succinate + a menaquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66127", "l": "2-oxobutanoate + L-histidine <=> (2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031692", "l": "alpha-1B adrenergic receptor binding", "d": ["Binding to an alpha-1B adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202248", "l": "Phosphorylation of PLC-gamma1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29341", "l": "(S)-malate(out) + 2 H(+)(out) => (S)-malate(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51686", "l": "(2E,6E)-farnesyl diphosphate + CDP => (2E,6E)-farnesyl phosphate + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22002", "l": "D-xylono-1,5-lactone + H(+) + NADPH => D-xylose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27841", "l": "9H-carbazole + H(+) + NADH + O2 <=> 2'-aminobiphenyl-2,3-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70039", "l": "3-dehydro-6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 3-dehydroteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67903", "l": "glutarate + succinyl-CoA <=> glutaryl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64835", "l": "3-hydroxybenzyl alcohol + benzoyl-CoA <=> 3-hydroxy-benzyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49185", "l": "chlorophyllide a + H(+) + H2O => 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68887", "l": "3-hydroxybenzoate + ATP + H(+) + NADPH <=> 3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864595", "l": "TFAP2B homodimer binds YEATS4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015528", "l": "lactose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198813", "l": "GSTO dimers reduce DeHA to AscH- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1972385", "l": "ADP-Ribosylation of HNP-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47189", "l": "Co(I)-[methylated-thiol-specific corrinoid protein] + methanethiol => hydrogen sulfide + methyl-Co(III)-[methylated-thiol-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28486", "l": "Fe(2+)(in) = Fe(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45838", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001888", "l": "glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0003861", "l": "3-isopropylmalate dehydratase activity", "d": ["Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204773", "l": "Interaction of Tie2 and Grb7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362386", "l": "Glycosylation of Hh (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878266", "l": "IHH gene transcription is stimulated by RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434130", "l": "IRAK4 binds to activated TLR5 or 15. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12138", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10712", "l": "L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O", "d": []}, {"i": "EC:1.13.12.9", "l": "\"phenylalanine 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64485", "l": "acetyl-CoA + 6 H(+) + holo-[ACP] + 6 malonyl-CoA => 3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63499", "l": "4-nitrobenzaldehyde + H(+) + NADPH <=> 4-nitrobenzyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26012", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+) => 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9795134", "l": "Cipro is sulfonated to sulfo-Cipro (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66276", "l": "tigogenin + UDP-alpha-D-glucose = H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31884", "l": "(S)-2,3-epoxysqualene => delta-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65824", "l": "dec-9-enoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = dec-9-ynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46732", "l": "(2R,6)-dimethylheptanoyl-CoA = (2S,6)-dimethylheptanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14799", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+) => 2-dehydro-3-deoxy-D-gluconate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56775", "l": "2 AH2 + all-trans-adonixanthin + 2 O2 <=> 2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190261", "l": "FGFR3c binds to FGF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44944", "l": "1-O-alkyl-3-acyl-sn-glycerol + H2O = 1-O-alkyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166387", "l": "The FA anion diffuses away laterally from UCP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56745", "l": "2-oxoglutarate + L-arginyl-[protein] + O2 => (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879298", "l": "acetylglucosamine is transferred from UDP-GlcNAc onto inositol-1-phosphate (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606789", "l": "ARSB hydrolyses DS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664933", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55773", "l": "a jasmonate + an L-alpha-amino acid + ATP => a jasmonyl-L-amino acid + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852013", "l": "BTNL8 binds resting T cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007462", "l": "CDC7 gene expression is repressed by the PRC1L4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17828", "l": "ATP + D-glucose <=> ADP + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32007", "l": "9alpha-copalyl diphosphate = diphosphate + isopimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57615", "l": "20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH <=> 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67480", "l": "2-oxoglutarate + O2 + prekainate = CO2 + H2O + kainate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23242", "l": "(6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate => (6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15849", "l": "2 Fe(III)-[cytochrome c] + L-ascorbate = 2 Fe(II)-[cytochrome c] + 2 H(+) + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209257", "l": "Phosphorylated REL-68 forms a complex with PCAF at its target gene and activates transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449117", "l": "TXLNA (IL14) binds syntaxin1A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45827", "l": "H(+) + L-serine <=> CO2 + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19973", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + S-methyl-5'-thioadenosine + spermine", "d": []}, {"i": "EC:2.5.1.22", "l": "\"spermine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031807", "l": "H1 histamine receptor binding", "d": ["Binding to a H1 histamine receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140793", "l": "histone H2AXY142 phosphatase activity", "d": ["Catalysis of the reaction: histone H2AX tyrosine phosphate (position 142) + H2O = histone H2AX tyrosine (position 142) + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43843", "l": "26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9676257", "l": "Formation of the SET1A complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73179", "l": "S-adenosyl-L-methionine + scutellarein = H(+) + S-adenosyl-L-homocysteine + scutellarein 4'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9709098", "l": "DHFR dimer reduces FOLA to DHF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68083", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O <=> a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20905", "l": "(S)-2-hydroxypropyl-coenzyme M => (S)-1,2-epoxypropane + coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050005", "l": "isohexenylglutaconyl-CoA hydratase activity", "d": ["Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647660", "l": "GSDME (1-270) binds PIPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17572", "l": "(R)-reticuline + NADP(+) <=> 1,2-dehydroreticuline + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237160", "l": "MTA is cleaved and phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51608", "l": "(R)-2-hydroxyglutarate + pyruvate = (R)-lactate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36962", "l": "D-ribono-1,4-lactone + H(+) + NADH <=> D-ribose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31268", "l": "6-hydroxyhexanoate + NADP(+) => 6-oxohexanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694522", "l": "Inner coat assembly and cargo binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58996", "l": "H2O + indole-3-carbaldehyde + O2 = H(+) + H2O2 + indole-3-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42681", "l": "2 hercynine + 2 L-selenocysteine + O2 => 2 H2O + 2 hercynylselenocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51157", "l": "ATP + L-glutamate + tRNA(Glu) => AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55093", "l": "D-fructose + UDP-alpha-D-glucose => H(+) + sucrose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55404", "l": "[phosphate](n) + UTP = [phosphate](n+1) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68615", "l": "Formation of ORC(1-6) complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69517", "l": "N-acetyl-D-galactosamine + O2 => H2O2 + N-acetyl-D-galactosamino-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48026", "l": "dipropanoylglycerol + H(+) + propanoate => 1,2,3-tripropanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62161", "l": "H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate => N-(9Z-octadecenoyl) ethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12821", "l": "2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate", "d": []}, {"i": "EC:4.1.2.4", "l": "\"deoxyribose-phosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69127", "l": "Formation of the Flap Intermediate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48063", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18056", "l": "H2O + paraoxon <=> 4-nitrophenol + diethylphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52847", "l": "3,4-dihydroxybenzoate + UDP-alpha-D-glucose <=> 1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41287", "l": "H2O + N-tetradecanoylsphing-4-enine = sphing-4-enine + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41031", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647980", "l": "mature RAS proteins translocate to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299476", "l": "MPP cleaves targeting peptide (presequence) of inner membrane precursors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37715", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine = 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35627", "l": "delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose = delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.238", "l": "\"delphinidin 3,5-di-O-glucoside 3'-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71690", "l": "glycyl-L-aspartate(out) + 2 H(+)(out) <=> glycyl-L-aspartate(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54732", "l": "N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874718", "l": "TTPA binds alpha-TOH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32211", "l": "(Z)-5-oxohex-2-enedioate = (2E,4Z)-2-hydroxyhexa-2,4-dienedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034934", "l": "phenanthrene-4-carboxylate dioxygenase activity", "d": ["Catalysis of the reaction: phenanthrene-4-carboxylate + 2 H+ + 2 e- + O2 = cis-3,4-phenanthrenedihydrodiol-4-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43325", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38171", "l": "hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63099", "l": "ilicicolin A epoxide <=> ilicicolin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047043", "l": "3-alpha-hydroxycholanate dehydrogenase activity", "d": ["Catalysis of the reaction: lithocholate + NAD+ = 3-oxo-5beta-cholanate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160047", "l": "muramyl dipeptide kinase activity", "d": ["Catalysis of the reaction: ATP + muramyl dipeptide = ADP + H(+) + 6-O-phospho-muramyl dipeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168456", "l": "Growth hormone receptor binds Lyn (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937792", "l": "RUNX3 binds SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011083", "l": "ROBO1 gene expression is inhibited by LHX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031719", "l": "type 2 cannabinoid receptor binding", "d": ["Binding to a type 2 cannabinoid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53846", "l": "7-oxoglycolithocholate + H(+) + NADH => glycochenodeoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64685", "l": "L-threonyl-[protein] + UDP-alpha-D-glucose => 3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44111", "l": "H2O + heptanal + NAD(+) <=> 2 H(+) + heptanoate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047883", "l": "ethanolamine oxidase activity", "d": ["Catalysis of the reaction: ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12899", "l": "(+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10925", "l": "cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide => trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45230", "l": "a 4-saturated (2E)-enoyl-CoA => a (3E)-enoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8858500", "l": "CLEC10A binds Tn-MUC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800380", "l": "PTPRD binds IL1RAP-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55002", "l": "3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62778", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17171", "l": "CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate => acetyl-CoA + alpha-D-galactosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21133", "l": "H2O + O2 + xanthine => H2O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0046524", "l": "sucrose-phosphate synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20707", "l": "a D-alpha-amino acid + acetyl-CoA <=> an N-acetyl-D-amino acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48205", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA => (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32460", "l": "2 S-adenosyl-L-methionine + uroporphyrinogen III => H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64725", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610726", "l": "The IFT-A complex recruits TULP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183126", "l": "Factor B binds to surface-associated C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52855", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] <=> 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41733", "l": "[(1->4)-alpha-D-glucosyl](n) + phosphate => [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67941", "l": "2-hydroxyoctanoate + O2 => 2-oxooctanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23309", "l": "(E)-sinapoyl-CoA + D-glucarate => 2-O-[(E)-sinapoyl]-D-glucarate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31617", "l": "dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67649", "l": "dATP + H2O => 2'-deoxyadenosine + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31402", "l": "all-trans-4,4'-diapophytofluene + FAD + H(+) <=> all-trans-4,4'-diapo-zeta-carotene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102664", "l": "indole-3-acetyl-leucine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-leucine + ATP <=> H+ + indole-3-acetyl-leucine + diphosphoric acid + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002046", "l": "opsin binding", "d": ["Binding to an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30064", "l": "2-demethylmenaquinol-8 + S-adenosyl-L-methionine => H(+) + menaquinol-8 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0005167", "l": "neurotrophin TRK receptor binding", "d": ["Binding to a neurotrophin TRK receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43739", "l": "adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25017", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": []}, {"i": "EC:3.1.3.67", "l": "\"phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23271", "l": "guanidinoacetate + H2O <=> glycine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39190", "l": "(3R)-hydroxydocosanoyl-CoA <=> (2E)-docosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47160", "l": "4beta-methylzymosterol-4alpha-carboxylate + NAD(+) = 3-dehydro-4-methylzymosterol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50725", "l": "(E)-4-hydroxyphenylacetaldehyde oxime => (Z)-(4-hydroxyphenyl)acetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428273", "l": "SPHK1 phosphorylates SPG to S1P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948594", "l": "miR-19a microRNA binds VAPA mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734687", "l": "ORC6 is phosphorylated on T195 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12439", "l": "(E)-caffeoyl-CoA + putrescine <=> CoA + H(+) + N-caffeoylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17803", "l": "CoA + H(+) + N-acetyl-L-phenylalanine => acetyl-CoA + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14154", "l": "17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine => 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.42903515889401", "identifiers": [{"i": "GO:0015279", "l": "store-operated calcium channel activity", "d": ["A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores."]}, {"i": "REACT:R-HSA-434798", "l": "CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64780", "l": "S-benzyl-L-cysteine = 2-aminoprop-2-enoate + benzylthiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28141", "l": "H2O + streptothricin F <=> streptothricin F acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71400", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin => 2alpha-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687088", "l": "PKA phosphorylates MAPKAPK5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72237", "l": "2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in) => 2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688294", "l": "SIRT5 deacetylates Cytochrome C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63277", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 => a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32153", "l": "(12E)-9alpha-labda-8(17),12,14-triene + diphosphate => 9alpha-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63706", "l": "H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP => mycophenolate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49391", "l": "UDP-alpha-D-glucose + validoxylamine A <=> H(+) + UDP + validamycin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66991", "l": "4-methylpentanoate + ATP + CoA <=> 4-methylpentanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392749", "l": "Transport of L1 into endosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49614", "l": "2-oxoglutarate + H(+) + NADH => (R)-2-hydroxyglutarate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688786", "l": "ATXN3 binds RAD23 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111970", "l": "PKC phosphorylates GRK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24726", "l": "N-demethylindolmycin + S-adenosyl-L-methionine = H(+) + indolmycin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.328", "l": "\"N-demethylindolmycin N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46379", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5681987", "l": "LC3 is cleaved by ATG4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27345", "l": "FMNH2 + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)", "d": []}, {"i": "EC:1.13.11.79", "l": "\"aerobic 5,6-dimethylbenzimidazole synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17993", "l": "ATP + beta-alanine + gamma-L-glutamyl-L-cysteine = ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.23", "l": "\"homoglutathione synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70935", "l": "L-lysine(in) = L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517705", "l": "p-S318,221-HuR binds mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159771", "l": "Furin cleaves pro-protein C to protein C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419003", "l": "Interaction of Nectins with Afadin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9008412", "l": "CDK4 phosphorylates RUNX2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53130", "l": "epsilon-carotene => delta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14675", "l": "a polar amino acid(in) + ADP + H(+) + phosphate => a polar amino acid(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18428", "l": "L-quinate + NADP(+) <=> 3-dehydroquinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707659", "l": "Hemes:LY96 activates TLR4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38781", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48519", "l": "1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14763", "l": "3-oxosphinganine + CO2 + CoA => H(+) + hexadecanoyl-CoA + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936615", "l": "acetylation of serine (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68690", "l": "3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3beta-androst-5-en-17-one 3-O-(beta-D-glucuronate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38163", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669024", "l": "CD70 binds CD27 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654571", "l": "Activated FGFR1 binds FRS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54751", "l": "ATP + CoA + firefly L-luciferin <=> AMP + diphosphate + L-firefly luciferyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26269", "l": "Co-precorrin-2 + 3 H(+) = Co(2+) + precorrin-2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804741", "l": "MDM2 forms homo- or heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649733", "l": "mature p21 RAS binds GDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31788", "l": "H2O + tuberculosinyl diphosphate => (13R)-edaxadiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34914", "l": "D-methionine(in) <=> D-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389350", "l": "Activation of Cdc42 by pVav1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210290", "l": "Interaction of PECAM-1 and SHIP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0034318", "l": "alcohol O-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to an oxygen atom on an alcohol acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683593", "l": "ATG7:ATG3:LC3 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43771", "l": "an alkylamine + L-glutaminyl-[protein] <=> N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.17", "l": "\"quinoline 2-oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60726", "l": "dodecanoate + 2 H(+) + NADPH => dodecanal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40919", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35111", "l": "2-dehydro-L-idonate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.346", "l": "\"2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000112", "l": "CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732729", "l": "Activated JAK1 binds RAF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11848", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine = [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate", "d": []}, {"i": "EC:1.21.4.4", "l": "\"betaine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782881", "l": "LCMT2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033767", "l": "4-hydroxyacetophenone monooxygenase activity", "d": ["Catalysis of the reaction: 4'-hydroxyacetophenone + H+ + NADPH + O2 = 4-hydroxyphenyl acetate + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086038", "l": "calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49833", "l": "a fatty aldehyde + H2O + NAD(+) => a fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164617", "l": "Elongation of Extended Telomeric Chromosome End (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52226", "l": "3 A + biliverdin delta + CO + Fe(2+) + 3 H2O => 3 AH2 + 3 H(+) + heme b + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24867", "l": "4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202969", "l": "Caspase mediated cleavage of beta-catenin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129353", "l": "Tropoelastin associates with microfibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68715", "l": "(2E,6E)-farnesyl diphosphate <=> (1S,2S,4R)-beta-elemene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009072", "l": "STAT3 phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69670", "l": "H2O + luteolin 4'-O-beta-D-glucoside <=> beta-D-glucose + luteolin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161282", "l": "Elastic fibres bind associated proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19167", "l": "1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64138", "l": "(9Z)-octadecenoate + L-asparagine => H2O + N-(9Z-octadecenoyl)-L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202375", "l": "Recruitment of ITK to SLP-76 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23590", "l": "oxalyl-CoA + succinate => oxalate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018747", "l": "RHOQ GEFs activate RHOQ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218814", "l": "PAK2 autophorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72929", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin IV => O2 + proatranorin I + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35833", "l": "2'-dehydrokanamycin A + CO2 + NH4(+) + succinate => 2-oxoglutarate + kanamycin B + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2032770", "l": "Translocation of YAP1 to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864569", "l": "WWOX binds TFAP2C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68853", "l": "(2E,6E)-farnesyl diphosphate + H2O => (1S,6S,7R)-sesquipiperitol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944218", "l": "Association of procollagen type VIII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11497", "l": "O-acetyl-L-serine + uracil => 3-(uracil-1-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12236", "l": "H2O + NADP(+) + nicotinate = 6-hydroxynicotinate + H(+) + NADPH", "d": []}, {"i": "EC:1.17.1.5", "l": "\"nicotinate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18116", "l": "a ribonucleoside 5'-diphosphate + ATP <=> a ribonucleoside 5'-triphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71262", "l": "2 Na(+)(out) + phosphate(out) <=> 2 Na(+)(in) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166220", "l": "FA anion diffuses laterally to UCP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63612", "l": "prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.69", "l": "\"protein C (activated)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28043", "l": "CoA + NAD(+) + pyruvate => acetyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877361", "l": "Pyrin binds ASC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20279", "l": "an N-acetoxyarylamine + CoA => acetyl-CoA + an N-hydroxyarylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44467", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60061", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose => alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803403", "l": "PCBP4 binds the CDKN1A mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37684", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA => 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.7.1.-", "l": "\"Forming diazo bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9702818", "l": "CALCR binds erenumab (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54836", "l": "H(+) + heptan-2-one + NADPH + O2 = H2O + NADP(+) + pentyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54327", "l": "a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin] <=> a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70596", "l": "GOT2 dimer deaminates L-Asp (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47800", "l": "4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid = an aromatic oxo-acid + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55763", "l": "a fatty acyl-[ACP] + a lyso-ornithine lipid <=> an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000774", "l": "adenyl-nucleotide exchange factor activity", "d": ["Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins."]}, {"i": "REACT:R-HSA-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944454", "l": "mTORC1 phosphorylates MAF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51263", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] <=> (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201622", "l": "Caspase-mediated cleavage of gelsolin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60881", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36869", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679044", "l": "FKBP1A binds sirolimus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24981", "l": "3-hydroxy-4-methylanthranilate + ATP + H(+) => 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70841", "l": "L-arginine(out) + L-histidine(in) + Na(+)(in) => L-arginine(in) + L-histidine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46435", "l": "(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419011", "l": "Transhomodimerization of Nectins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65246", "l": "(2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP => (2S)-hesperetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395517", "l": "NADPH transfers electrons to FDXR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709842", "l": "MAVS binds TOMM70 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74711", "l": "Phosphorylation of IRS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64504", "l": "AH2 + H(+) + 3 malonyl-CoA + propanoyl-CoA + 2 S-adenosyl-L-methionine = 2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.65", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698005", "l": "FLT3 ITD mutants phosphorylate STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004829", "l": "threonine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865482", "l": "KMT2A (MLL) binds RUNX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74736", "l": "S-adenosyl-L-methionine + syringetin => 7,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29766", "l": "ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) <=> ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12170", "l": "acrolein + H(+) + NADPH => allyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031869", "l": "prostacyclin receptor binding", "d": ["Binding to a prostacyclin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114354", "l": "SMAC binds XIAP:Caspase-7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62408", "l": "3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine = 1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.365", "l": "\"MMP 1-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64375", "l": "beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O <=> alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16106", "l": "a (3S)-3-hydroxyacyl-CoA => a (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604499", "l": "Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24150", "l": "(2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004107", "l": "chorismate synthase activity", "d": ["Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351455", "l": "Phosphorylation of NBS1 by ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45548", "l": "phycourobilin-L-cysteinyl(84)-[R-phycocyanin alpha-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[R-phycocyanin alpha-subunit]", "d": []}, {"i": "EC:4.4.1.33", "l": "\"R-phycocyanin alpha-cysteine-84 phycourobilin lyase/isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987214", "l": "p-STAT3 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.281967957033203", "identifiers": [{"i": "GO:0005183", "l": "gonadotropin hormone-releasing hormone activity", "d": ["The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69687", "l": "genistein 7-O-beta-D-glucoside + H2O = beta-D-glucose + genistein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50040", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0008119", "l": "thiopurine S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202111", "l": "AKT1 phosphorylates eNOS (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.87", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9761344", "l": "USP18 binds IKBKG within IKK complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64490", "l": "3,5,7,9,11-pentaoxododecanoyl-[ACP] + 5 CO2 + 6 CoA => acetyl-CoA + 5 H(+) + holo-[ACP] + 5 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32115", "l": "2-oxoglutarate + DIBOA beta-D-glucoside + O2 = CO2 + succinate + TRIBOA beta-D-glucoside", "d": []}, {"i": "EC:1.14.11.59", "l": "\"2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214859", "l": "Activated PLL kinase is autophosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047103", "l": "3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al = NADH + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73126", "l": "isorhamnetin + S-adenosyl-L-methionine <=> H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69867", "l": "a uridine in RNA + S-adenosyl-L-methionine = a 5-methyluridine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11450", "l": "H(+) + NADH + pregnan-21-al => NAD(+) + pregnan-21-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14775", "l": "corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine => 2 NADPH + palmatine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601922", "l": "Complexed PIWIL2 binds cleaved transposon RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10709", "l": "alpha-D-glucose 1-phosphate + GTP + H(+) => diphosphate + GDP-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72273", "l": "formate(in) + oxalate(out) => formate(out) + oxalate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613666", "l": "p-PLINs translocate from lipid droplet surface to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56592", "l": "a disubstituted aliphatic (S)-hydroxynitrile = a ketone + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64783", "l": "S-benzyl-L-cysteine <=> 2-aminoprop-2-enoate + benzylthiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21551", "l": "H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] <=> acetate + L-lysyl-[alpha-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11745", "l": "H2O + thiamine triphosphate => H(+) + phosphate + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63167", "l": "H2O + N-tricosanoyl-taurine <=> taurine + tricosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73941", "l": "dehydrogriseofulvin + H(+) + S-adenosyl-L-homocysteine => desmethyl-dehydrogriseofulvin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67800", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(27)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20113", "l": "beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate", "d": []}, {"i": "EC:5.4.2.6", "l": "\"beta-phosphoglucomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254392", "l": "PGR gene expression is stimulated by ERBB4s80:ESR1:estrogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392129", "l": "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54667", "l": "(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene <=> pre-alpha-onocerin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0022885", "l": "bacteriocin transmembrane transporter activity", "d": ["Enables the transfer of a bacteriocin from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103074", "l": "glucose-6-phosphate 3-dehydrogenase activity", "d": ["Catalysis of the reaction: NAD + D-glucopyranose 6-phosphate = NADH + H+ + 3-dehydro-D-glucose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45653", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20770", "l": "CO2 + phosphonoacetaldehyde => 3-phosphonopyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102004", "l": "2-octaprenyl-6-hydroxyphenol methylase activity", "d": ["Catalysis of the reaction: 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> H+ + 2-methoxy-6-(all-trans-octaprenyl)phenol + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34069", "l": "diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198714", "l": "ERK5 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229132", "l": "AP4 binds APP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57004", "l": "acetyl-CoA + streptothricin D = CoA + H(+) + N(beta)-acetylstreptothricin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69251", "l": "H2O + sinigrin <=> (Z)-N-(sulfonatooxy)prop-2-enimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560473", "l": "Expression of ANGPTL4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55075", "l": "2-oxobutanoate + H(+) <=> CO2 + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71115", "l": "H(+) + hispidin + NADH + O2 = 3-hydroxyhispidin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42187", "l": "5alpha-androstane-3beta,17beta-diol + NAD(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380782", "l": "STAT binds to the active receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71738", "l": "formyl-CoA + succinate <=> formate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58450", "l": "H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62467", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984733", "l": "Kinesin-3 is a dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977375", "l": "CR1 binds C3bBb/C4bC2a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395364", "l": "LTBP4 binds TGF-Beta-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084912", "l": "Arresten binds integrin alpha1beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66872", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17009", "l": "2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.26", "l": "\"o-succinylbenzoate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68135", "l": "phytol + tetradecanoyl-CoA <=> CoA + tetradecanoate phytyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.6", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.413456430472493", "identifiers": [{"i": "GO:0070566", "l": "adenylyltransferase activity", "d": ["Catalysis of the transfer of an adenylyl group to an acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53779", "l": "3-sulfanylpropanoate + O2 <=> 3-sulfinopropanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47372", "l": "a quinone + D-glucose = a quinol + D-glucono-1,5-lactone", "d": []}, {"i": "EC:1.1.5.9", "l": "\"glucose 1-dehydrogenase (FAD, quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-990489", "l": "Kinesin-13 is a dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74335", "l": "O-2-methylbutanoyl-(R)-carnitine(in) = O-2-methylbutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102319", "l": "2-deoxystreptamine N-acetyl-D-glucosaminyltransferase activity", "d": ["Catalysis of the reaction: 2-deoxystreptamine(2+) + UDP-N-acetyl-alpha-D-glucosamine <=> H+ + 2'-N-acetylparomamine(2+) + UDP(3-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16130", "l": "NADP(+) + pyridoxine => H(+) + NADPH + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34549", "l": "ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate => ATP + cob(II)yrinate + H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.-", "l": "\"Phosphoric monoester hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0008083", "l": "growth factor activity", "d": ["The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37285", "l": "L-alanine + L-histidine => H2O + L-alanyl-L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64091", "l": "acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA <=> 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237140", "l": "Dehydration of methylthio-ribulose-P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665727", "l": "FMNL2 binds CDC42:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37625", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-171122", "l": "LDL + LDLR => LDL:LDLR complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110157", "l": "UNG glycosylase mediated recognition and binding of a 5-hydroxyuracil opposite to a guanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30654", "l": "2 H2O + O2 + urate <=> allantoin + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28549", "l": "alpha-D-glucose <=> alpha-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008701", "l": "4-hydroxy-2-oxovalerate aldolase activity", "d": ["Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "ic": "50.34104854443882", "identifiers": [{"i": "GO:0022890", "l": "inorganic cation transmembrane transporter activity", "d": ["Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10525", "l": "2-oxoglutarate + H(+) => CO2 + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41052", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41535", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791184", "l": "Expression of ATP6VOD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033722", "l": "malonate-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 3-oxopropanoate + NAD(P)+ + H2O = malonate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20461", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine = an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.344", "l": "\"ornithine lipid N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.52", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25570", "l": "ADP + H(+) + nicotinate beta-D-ribonucleotide => ATP + beta-D-ribosylnicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14973", "l": "L-aspartate = D-aspartate", "d": []}, {"i": "EC:5.1.1.13", "l": "\"aspartate racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624014", "l": "SHC1 is phosphorylated downstream of estrogen stimulation of GPER1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418091", "l": "F2R binds ARRB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2219524", "l": "PDPK1 binds PIP2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209903", "l": "Noradrenaline is converted to adrenaline (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69931", "l": "inosine(out) + Na(+)(out) = inosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809309", "l": "MTMR6 binds MTMR9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51254", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63694", "l": "a beta-D-glucuronoside + H(+) + UDP => alcohol glucuronate acceptor + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373727", "l": "Nephrin binds CD2AP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0015159", "l": "polysaccharide transmembrane transporter activity", "d": ["Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004300", "l": "enoyl-CoA hydratase activity", "d": ["Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5669158", "l": "NF2 binds PAK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002401", "l": "Association of procollagen type XVIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38973", "l": "(2E)-octadecenoyl-CoA + H2O2 => O2 + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810392", "l": "TMEM55B translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50228", "l": "FADH2 + O2 + resorcinol = benzene-1,2,4-triol + FAD + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.27", "l": "\"resorcinol 4-hydroxylase (FADH2)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36626", "l": "3-phenylpyruvate + S-adenosyl-L-methionine <=> (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50505", "l": "acetyl-CoA + N-terminal L-seryl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803411", "l": "PCBP4 modulates CDKN1A translation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41974", "l": "CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047841", "l": "dehydrogluconokinase activity", "d": ["Catalysis of the reaction: 2-dehydro-D-gluconate + ATP = 6-phospho-2-dehydro-D-gluconate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38579", "l": "dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.120", "l": "\"dammarenediol 12-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004956", "l": "prostaglandin D receptor activity", "d": ["Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71208", "l": "iodide(out) + 2 Na(+)(out) => iodide(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222020", "l": "NUAK1 phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45520", "l": "phycoviolobilin-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit]", "d": []}, {"i": "EC:4.4.1.31", "l": "\"phycoerythrocyanin alpha-cysteine-84 phycoviolobilin lyase/isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74093", "l": "ADP + H(+) + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ATP + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416690", "l": "SEMA4A binds to PLXND1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14552", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> 2-oxopent-4-enoate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102305", "l": "(13E)-labda-7,13-dien-15-ol synthase activity", "d": ["Catalysis of the reaction: 2-cis,6-trans,10-trans-geranylgeranyl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534096", "l": "METAP1/2 demethylates GNAT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9716947", "l": "ESR1 binds ESR1 agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16590", "l": "A + sucrose => 3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34734", "l": "15-methylhexadecasphing-4-enine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38206", "l": "19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23110", "l": "D-arabinonate + H(+) => D-arabinono-1,4-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15736", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O <=> (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55526", "l": "3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-dopa + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37089", "l": "3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15330", "l": "(S)-ureidoglycolate + NAD(+) => H(+) + N-carbamoyl-2-oxoglycine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66747", "l": "ATP + H2O + N-acetyl-L-aspartate(in) <=> ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12017", "l": "(2E,6E)-farnesyl diphosphate => (-)-germacrene D + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950782", "l": "p-STAT1 binds p-STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64563", "l": "butan-2-ol + NAD(+) <=> butan-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49456", "l": "(2S)-2-amino-4-deoxychorismate + H2O = (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate", "d": []}, {"i": "EC:3.3.2.15", "l": "\"trans-2,3-dihydro-3-hydroxyanthranilic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18167", "l": "(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) => biphenyl + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65737", "l": "2-oxoglutarate + O2 + octyl sulfate => CO2 + H(+) + octanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9634834", "l": "ACHEIs bind ACHE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43503", "l": "beta-D-glucuronate + NAD(+) <=> D-glucaro-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53472", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53423", "l": "8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine <=> H(+) + roseoflavin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46154", "l": "15,9'-di-cis-phytofluene + a plastoquinol => 15-cis-phytoene + a plastoquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29572", "l": "H(+)(in) + L-idonate(in) => H(+)(out) + L-idonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112037", "l": "Inactivation of PLC beta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419166", "l": "GEFs activate RhoA,B,C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58683", "l": "A + FADH2 <=> AH2 + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47185", "l": "5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918230", "l": "Recruitment of TRAF6/TRAF2 to IPS-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353301", "l": "Binding of Pol kappa and REV1 complex to the lesion on the template DNA strand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73419", "l": "L-glutamine(out) = L-glutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179293", "l": "UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004809", "l": "tRNA (guanine-N2-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187575", "l": "Ubiquitination of phospho-p27/p21 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29244", "l": "H(+) + menaquinone-8 + NADH => menaquinol-8 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13266", "l": "1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine => 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51588", "l": "isopyridoxal + NAD(+) = 5-pyridoxolactone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.416", "l": "\"isopyridoxal dehydrogenase (5-pyridoxolactone-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47275", "l": "monoanhydrobacterioruberin <=> bisanhydrobacterioruberin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168136", "l": "Activated JNKs phosphorylate c-JUN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961895", "l": "CCNA1 gene expression is stimulated by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204779", "l": "Interaction of Tie2 with Ang1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33819", "l": "3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate = 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate", "d": []}, {"i": "EC:5.3.3.19", "l": "\"3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40878", "l": "(9Z,12Z)-octadecadienoyl-CoA + FAD + H(+) <=> (2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043862", "l": "arginine:agmatine antiporter activity", "d": ["Catalysis of the reaction: arginine(out) + agmatine(in) = arginine(in) + agmatine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32977", "l": "2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65358", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37440", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate => a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27670", "l": "1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53061", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate => estrone 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31434", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-beta-santalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12619", "l": "ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate => ATP + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46493", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433456", "l": "Recruitment of STATs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66982", "l": "2-methylbutanoate + CoA + H(+) => 2-methylbutanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417820", "l": "P2Y9 receptor can bind to LPA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60798", "l": "3 CO2 + gibberellin A20 + 2 H2O + 2 succinate => 2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.313", "l": "\"25S rRNA (uracil(2634)-N(3))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080115", "l": "myosin XI tail binding", "d": ["Binding to the tail region of a myosin XI heavy chain."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018830", "l": "gamma-hexachlorocyclohexane dehydrochlorinase activity", "d": ["Catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55580", "l": "ATP + H2O + L-glutamine = AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate", "d": []}, {"i": "EC:2.7.3.13", "l": "\"glutamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61539", "l": "ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70305", "l": "cholesteryl 3-beta-D-glucoside + N-octanoylsphing-4-enine => beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769397", "l": "SOST binds LRP5/6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57674", "l": "2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52050", "l": "(9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+) => 9-(9Z-octadecenoyloxy)-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8941895", "l": "Formation of CDK4/6:CCND complexes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450494", "l": "HuR binds mRNAs in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690152", "l": "USP5 cleaves polyubiquitin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41842", "l": "(3R)-hydroxyoctanoyl-[ACP] + NADP(+) => 3-oxooctanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678981", "l": "TLR9 processing at neutral pH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432427", "l": "PP1 dephosphorylates phosphorylated TIM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047746", "l": "chlorophyllase activity", "d": ["Catalysis of the reaction: chlorophyll + H2O = phytol + chlorophyllide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56651", "l": "3-oxochol-4-en-24-oyl-CoA + NAD(+) <=> 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016941", "l": "natriuretic peptide receptor activity", "d": ["Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4837364", "l": "Secretion of SOD3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177923", "l": "Sustained activation of SRC kinase by SHP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71871", "l": "(S)-3-hydroxybutanoate(out) + H(+)(out) = (S)-3-hydroxybutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710353", "l": "GSDMD (1-275) binds cardiolipin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23145", "l": "H2O + N-acetyl-alpha-D-glucosamine + NAD(+) => 2 H(+) + N-acetyl-D-glucosaminate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41742", "l": "2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine => adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73006", "l": "anthranilate + 2 ATP + L-tryptophan <=> (R)-benzodiazepinedione + 2 AMP + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45138", "l": "7,8-dihydroneopterin 3'-phosphate + H2O => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64954", "l": "dCMP + H(+) + phosphate => dCDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871265", "l": "YAP1 binds TEAD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811427", "l": "COPI vesicle uncoating at the ER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205286", "l": "GRB2:SOS interacts with p-KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43642", "l": "3-oxotetradecanoyl-[ACP] + CO2 + CoA => dodecanoyl-CoA + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70491", "l": "GDP-beta-L-fucose + L-threonyl-[protein] = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801109", "l": "CHM binds RGGT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015366", "l": "malate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72663", "l": "De novo formation of eIF2:GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51139", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 <=> (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71164", "l": "homogentisate + O2 => maleylacetoacetate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981355", "l": "RASA1 binds RAS:GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24737", "l": "2-oxoglutarate + 4-hydroxybutanoate <=> (R)-2-hydroxyglutarate + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48077", "l": "a primary alcohol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-390329", "l": "Dephosphorylation of AKT by PP2A (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13817", "l": "[protein]-disulfide + H2O + phylloquinone = 2,3-epoxyphylloquinone + [protein]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30953", "l": "alpha-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265456", "l": "NPC1L1 binds ezetimibe (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983138", "l": "Transport of MHC heterotrimer to ER exit site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14023", "l": "20-hydroxyecdysone + A + H2O => AH2 + ecdysone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730847", "l": "Hydrolysis of PIP2 by PLCG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64901", "l": "H2O + UTP => H(+) + phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050082", "l": "maltose phosphorylase activity", "d": ["Catalysis of the reaction: maltose + phosphate = D-glucose + beta-D-glucose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22920", "l": "L-glutamine + scyllo-inosose = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate", "d": []}, {"i": "EC:2.6.1.50", "l": "\"glutamine--scyllo-inositol transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374298", "l": "Opioid receptors bind opioid peptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57742", "l": "a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH => a 2,3-saturated meromycolyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008110", "l": "Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2529020", "l": "CK2 phosphorylates condensin I subunits (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56110", "l": "2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => genistein + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004049", "l": "anthranilate synthase activity", "d": ["Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1467209", "l": "Binding of defensins to lipid II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75337", "l": "bromide(out) + chloride(in) => bromide(in) + chloride(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21782", "l": "AH2 + cyclohex-2-enone => A + cyclohexanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660479", "l": "MTF1 dimer:12Zn2+ binds SNCB gene (beta-synuclein) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67923", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0097603", "l": "temperature-gated ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37169", "l": "(2E,6E)-farnesal + H(+) + NADH => (2E,6E)-farnesol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420233", "l": "VIP receptors bind VIP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69733", "l": "AMP + H(+) + phenylacetyl-CoA => CoA + phenylacetyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805122", "l": "AURKB binds TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22386", "l": "1D-myo-inositol hexakisphosphate + H(+) + phosphate => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013159", "l": "CDC42 GEFs activate CDC42 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0042289", "l": "MHC class II protein binding", "d": ["Binding to a major histocompatibility complex class II molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.282738951573606", "identifiers": [{"i": "GO:0005227", "l": "calcium activated cation channel activity", "d": ["Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient."]}, {"i": "REACT:R-HSA-9717383", "l": "TRPM4 transports Na+ from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031699", "l": "beta-3 adrenergic receptor binding", "d": ["Binding to a beta-3 adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0003867", "l": "4-aminobutyrate transaminase activity", "d": ["Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686469", "l": "Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0003887", "l": "DNA-directed DNA polymerase activity", "d": ["Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36175", "l": "1-O-alkylglycerone 3-phosphate + H(+) + NADPH = 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102418", "l": "luteolin-7-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: luteolin 7-O-beta-D-glucoside + UDP-alpha-D-glucose = luteolin-7-O-gentiobioside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103044", "l": "ribosomal protein S6 glutamate-glutamate ligase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP + a [protein] C-terminal L-glutamate = ADP + hydrogenphosphate + H+ + a [protein] with C-terminal alpha-L-glutamate-alpha-L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71678", "l": "glycyl-L-leucine(out) + H(+)(out) <=> glycyl-L-leucine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814831", "l": "TBC1D20 binds RAB1:GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74636", "l": "2-oxoglutarate + 5-dehydro-6-demethoxyfumagillol + O2 => 5-dehydro-6-demethoxy-6-hydroxyfumagillol + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42212", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.871876592857262", "identifiers": [{"i": "GO:0140359", "l": "ABC-type transporter activity", "d": ["Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51351", "l": "acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine <=> 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11829", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O => a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21967", "l": "an acylcholine + H2O <=> a carboxylate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65005", "l": "ATP + decanoate + holo-[ACP] => AMP + decanoyl-[ACP] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604368", "l": "Autocatalytic activation of bound proMMP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72253", "l": "(R)-metanephrine + H(+) + S-adenosyl-L-homocysteine => (R)-adrenaline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941895", "l": "Formation of CDK4/6:CCND complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9652264", "l": "ERBB2 binds TKIs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58188", "l": "all-trans-lycopene + dimethylallyl diphosphate + H2O = dihydroisopentenyldehydrorhodopin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202692", "l": "PIP3 binds to RhoA and activates it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46717", "l": "pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110319", "l": "Elongation by POLH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53232", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429036", "l": "SLC2A9 transports Fru, Glc, urate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0030228", "l": "lipoprotein particle receptor activity", "d": ["Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56399", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70510", "l": "LDH tetramer oxidises LACT to PYR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005166", "l": "neurotrophin p75 receptor binding", "d": ["Binding to a neurotrophin p75 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72180", "l": "Cleavage of mRNA at the 3'-end (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36646", "l": "emodin + S-adenosyl-L-methionine <=> H(+) + questin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73512", "l": "2-oxoglutarate + 8-hydroxysalvigenin + O2 => CO2 + formaldehyde + pilosin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210439", "l": "glutamate uptake by astrocytes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801666", "l": "PLK2 phosphorylates CENPJ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60341", "l": "N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59902", "l": "CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate => 2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870466", "l": "RGGT:CHM binds RABs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0070568", "l": "guanylyltransferase activity", "d": ["Catalysis of the transfer of a guanylyl group to an acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20317", "l": "L-proline + NADP(+) = 1-pyrroline-2-carboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29136", "l": "a menaquinol + 2 H(+)(in) + nitrate => a menaquinone + 2 H(+)(out) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209341", "l": "Phosphorylation of SMO by PKA-C1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754974", "l": "ADK phosphorylates RBV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19211", "l": "codeinone + H(+) + NADPH => codeine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33546", "l": "ergosteryl palmitate + H2O <=> ergosterol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19964", "l": "a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate <=> a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698988", "l": "Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099635", "l": "voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels", "d": ["Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission."]}, {"i": "REACT:R-HSA-9659515", "l": "CACNA1D:CACNA2D2:CACNB2 (Cav1.3 channel) transports Ca2+ into the cytosol of an inner hair cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34134", "l": "neryl diphosphate + olivetolate <=> cannabinerolate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791157", "l": "Expression of DNAJC3 (p58IPK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45808", "l": "galactarate = (2S,3R)-dihydroxy-5-oxohexanedioate + H2O", "d": []}, {"i": "EC:4.2.1.158", "l": "\"galactarate dehydratase (D-threo-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12869", "l": "(2E)-geranyl diphosphate = (4S)-limonene + diphosphate", "d": []}, {"i": "EC:4.2.3.16", "l": "\"(4S)-limonene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38840", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32676", "l": "alpha,alpha-trehalose + H2O => alpha-D-glucose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50034", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine => H2O + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429955", "l": "CCR4-NOT complex deadenylates mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985227", "l": "The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60095", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) <=> 3-dehydro-4alpha-methylzymosterol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098606", "l": "selenocystathionine gamma-lyase activity", "d": ["Catalysis of the reaction: L-Selenocystathionine + H2O => L-Selenocysteine + NH3 + 2-Oxobutanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32166", "l": "ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47934", "l": "(2S)-3-sulfolactate + 2 H(+) + NADH => (2S)-3-sulfolactaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0043865", "l": "methionine transmembrane transporter activity", "d": ["Enables the transfer of methionine from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047652", "l": "allantoate deiminase activity", "d": ["Catalysis of the reaction: allantoate + H2O + H+ = CO2 + NH3 + ureidoglycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693111", "l": "RHOF auto-activates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54685", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (-)-kolavenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12381", "l": "L-2,4-diaminobutanoate + pyruvate => L-alanine + L-aspartate 4-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374173", "l": "AGT(34-41) binds to AGTR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296301", "l": "CCRL2 binds CCL19 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61130", "l": "H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase] => O2 + quercetin + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375138", "l": "CDO binds BOC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032315", "l": "oxo-DHAs translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0003884", "l": "D-amino-acid oxidase activity", "d": ["Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855111", "l": "VLDLR binds PCSK9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61564", "l": "a tetracycline + H(+) + NADPH + O2 = a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750942", "l": "USP14 deubiquitinates NLRC5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23937", "l": "D-gluconate + NADP(+) => 5-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59772", "l": "D-sorbitol + O2 = D-sorbopyranose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34572", "l": "C30 botryococcene + diphosphate + NADP(+) => H(+) + NADPH + presqualene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141423", "l": "Binding of the MCC complex to the APC/C complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43701", "l": "(2E,6E)-farnesoate + S-adenosyl-L-methionine => methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72631", "l": "Formation of the cap-binding eIF4F complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74899", "l": "(2E)-2-butenoate + ATP + holo-[ACP] = (2E)-butenoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61949", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444661", "l": "HCAR2 binds HCAR2 ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977629", "l": "Displacement of C2a/Bb by CR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68293", "l": "L-seryl-[protein] + nonanoyl-CoA => CoA + O-nonanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22285", "l": "2 H(+) + H2O + N-carbamoylputrescine => CO2 + NH4(+) + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18361", "l": "a dolichyl D-xylosyl phosphate + L-seryl-[protein] = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": []}, {"i": "EC:2.4.2.33", "l": "\"dolichyl-xylosyl-phosphate--protein xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848713", "l": "PTK6 binds BCAR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694421", "l": "PP6 dephosphorylates SEC24 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17527", "l": "NH4(+) + urea-1-carboxylate => biuret + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68133", "l": "phytol + tetradecanoyl-CoA => CoA + tetradecanoate phytyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683593", "l": "ATG7:ATG3:LC3 dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416698", "l": "SEMA5A binds to PLXNB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38312", "l": "carminomycin + S-adenosyl-L-methionine => daunorubicin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395340", "l": "Formation of hydroxyallysine by LOX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098622", "l": "selenodiglutathione-disulfide reductase (NADP) activity", "d": ["Catalysis of the reaction: H+ + selenodiglutathione + NADPH = gluthathioselenol + glutathione + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34964", "l": "Na(+)(in) => Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395784", "l": "Nascent CMs transform into mature CMs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296045", "l": "Activation of Potassium transport channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17584", "l": "an N-carbamoyl-L-alpha-amino acid + 2 H(+) + H2O <=> an L-alpha-amino acid + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11206", "l": "AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] => apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380574", "l": "Dopamine synaptic vesicle docking and priming (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54544", "l": "1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine = 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29769", "l": "ADP + D-methionine(in) + H(+) + phosphate => ATP + D-methionine(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63878", "l": "(4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate => 2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102782", "l": "cholestanol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + epidihydrocholesterin + O2 + NADPH = (22alpha)-hydroxy-cholestanol + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64695", "l": "isobutanol + NAD(+) <=> 2-methylpropanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.150", "l": "\"lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801101", "l": "RABGGTA binds RABGGTB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30477", "l": "D-glucuronate + H(+) + oroxylin A => H2O + oroxylin A 7-O-beta-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009001", "l": "serine O-acetyltransferase activity", "d": ["Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45621", "l": "H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912412", "l": "NOTCH1 mRNA translation controlled by miRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761825", "l": "NFE2L2 binds the ME1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2129375", "l": "Elastin cross-linking by lysyl oxidase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090440", "l": "abscisic acid transmembrane transporter activity", "d": ["Enables the transfer of abscisic acid from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466832", "l": "Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53485", "l": "androst-4-ene-3,11,17-trione + H(+) + NADPH => 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418850", "l": "Activation of Cdc42 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67858", "l": "3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13581", "l": "N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP", "d": []}, {"i": "EC:2.7.8.17", "l": "\"UDP-N-acetylglucosamine--lysosomal-enzyme N-acetylglucosaminephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632668", "l": "SMO translocates to the cilium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69642", "l": "H2O + phlorizin <=> beta-D-glucose + phloretin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32263", "l": "4-aminobutanoate + pyruvate = L-alanine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.426153789046865", "identifiers": [{"i": "GO:0016877", "l": "ligase activity, forming carbon-sulfur bonds", "d": ["Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}, {"i": "EC:6.2.-.-", "l": "\"Forming carbon-sulfur bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5681987", "l": "LC3 is cleaved by ATG4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634228", "l": "TRAF1 is cleaved by caspases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12199", "l": "keto-D-fructose 6-phosphate + phosphate <=> acetyl phosphate + D-erythrose 4-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47903", "l": "ganglioside GM3 (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67424", "l": "a glycerophospholipid + H2O = a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418172", "l": "F2R binds ARRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57693", "l": "2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] => 2 cob(I)inamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183067", "l": "Localization of CBL:GRB2 to the membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5669250", "l": "PAK1 phosphorylates FLNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23329", "l": "a 9-cis-epoxycarotenoid + O2 => 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33298", "l": "L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156912", "l": "Peptide transfer from P-site tRNA to the A-site tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29996", "l": "ATP + H2O + putrescine(out) => ADP + H(+) + phosphate + putrescine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33968", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O => 3-maleylpyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36173", "l": "1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+) => a 1-acylglycerone 3-phosphate + a long chain fatty alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50274", "l": "resolvin E1 => (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47095", "l": "(S)-2,3-dihydrodipicolinate + NADP(+) <=> dipicolinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663124", "l": "p-BMAL1:p-CLOCK,NPAS2 binds SERPINE1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5695964", "l": "ABHD14B hydrolyses PNPB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23691", "l": "adenine + H(+) + H2O <=> hypoxanthine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34336", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (22R)-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875374", "l": "MET binds LRIG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17391", "l": "D-ribulose + H(+) + NADH => D-arabinitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450975", "l": "isocitrate <=> citrate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62209", "l": "3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] => 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140817", "l": "NAD+-histone H3S10 serine ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of ADP-ribose groups to the serine-10 or an equivalent residue of the N-terminal tail of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46888", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + O2 = 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2", "d": []}, {"i": "EC:1.1.3.48", "l": "\"3-deoxy-alpha-D-manno-octulosonate 8-oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52610", "l": "2-oxobutanoate + H(+) + NADPH => 2-hydroxybutanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66182", "l": "ADP + bilirubin-glucuronoside(out) + H(+) + phosphate => ATP + bilirubin-glucuronoside(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18726", "l": "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA => acetyl-CoA + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38489", "l": "(9Z)-octadecenoate + glycerol + H(+) => 1-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803104", "l": "DCD forms oligomeric complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58851", "l": "(6E)-8-hydroxygeraniol + NAD(+) <=> (6E)-8-hydroxygeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784734", "l": "PCSK9 binds LDLR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75132", "l": "neomorphinone => morphinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445704", "l": "Calcium Binds Caldesmon (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693250", "l": "RHOD binds effectors at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51564", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.29", "l": "\"cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62186", "l": "diphosphate + labd-13(16),14-diene-9-ol => peregrinol diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53704", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O = H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46743", "l": "7-dehydrodesmosterol + H(+) + NADPH <=> desmosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694344", "l": "Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28700", "l": "Mn(2+)(in) => Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53077", "l": "cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine => 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17379", "l": "3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) => a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74998", "l": "epierythrostominol(in) <=> epierythrostominol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110215", "l": "Cleavage of uracil by UNG glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018807", "l": "RAC3 GDIs block activation of RAC3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51483", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419351", "l": "PAF receptor binds platelet activating factor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28694", "l": "(S)-dihydroorotate + a ubiquinone <=> a ubiquinol + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004316", "l": "3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24045", "l": "3,4-dihydroxybenzoate + O2 => 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724090", "l": "MYH9- and RNF213-ALK fusions are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55830", "l": "6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cortisol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5576895", "l": "SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52339", "l": "a long-chain fatty acid + ATP + H(+) <=> a long-chain fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060724", "l": "coreceptor activity involved in epidermal growth factor receptor signaling pathway", "d": ["Combining with an extracellular messenger, and in cooperation with a primary EGF receptor, initiating a change in cell activity through the EGF receptor signaling pathway."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102494", "l": "GA20 2,3-desaturase activity", "d": ["Catalysis of the reaction: gibberellin A20 + O2 + a reduced electron acceptor <=> gibberellin A5 + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3159253", "l": "MMAB adenosylates cob(I)alamin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22619", "l": "2 H(+) + O2 + 2 sulochrin <=> 2 (2R)-bisdechlorogeodin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624956", "l": "PDE6D binds INPP5E (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36193", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45673", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985943", "l": "p-Y701-STAT1 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42475", "l": "dibenzo-p-dioxin + NADH + O2 <=> 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22195", "l": "(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide <=> (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "64.260243218047506", "identifiers": [{"i": "GO:0005245", "l": "voltage-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24838", "l": "5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46494", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.11", "l": "\"2-haloacid dehalogenase (configuration-retaining)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24631", "l": "2 H2O + 3 NAD(+) + NH4(+) <=> 5 H(+) + 3 NADH + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3364042", "l": "APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917696", "l": "Cargo Sequestration (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11453", "l": "7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696267", "l": "RND3 binds GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799466", "l": "TP53I3 dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19986", "l": "NAD(+) + S-(hydroxymethyl)glutathione => H(+) + NADH + S-formylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112727", "l": "Serine phosphorylation of STATs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71281", "l": "chloride(in) + L-leucine(in) + 2 Na(+)(in) => chloride(out) + L-leucine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814555", "l": "Integrator complex processes the 3' end of snRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163549", "l": "phosphorylated HSL dimer + FABP4 -> phosphorylated HSL dimer:FABP4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031208", "l": "POZ domain binding", "d": ["Binding to a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71482", "l": "H2O + neurotensin <=> L-tyrosyl-L-isoleucyl-L-leucine + neurotensin(1-10)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14615", "l": "ADP + H(+) + phosphate + taurine(in) => ATP + H2O + taurine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-451418", "l": "Pellino ubiquitinates IRAK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001858", "l": "complement component iC3b receptor activity", "d": ["Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194793", "l": "botC LC cleaves target cell SNAP25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35989", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67497", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O => 3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106330", "l": "sialate 9-O-acetylesterase activity", "d": ["Catalysis of the reaction: H2O + N-acetyl-9-O-acetylneuraminate = acetate + H+ + N-acetylneuraminate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34054", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H2O <=> 6'''-deamino-6'''-hydroxyneomycin C + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130706", "l": "MHC class II antigen processing (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627056", "l": "Procaspase 9 forms dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013361", "l": "NEXT3 is cleaved to produce NICD3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008029", "l": "pentraxin receptor activity", "d": ["Combining with a pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684275", "l": "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621385", "l": "EGR1 binds TRIB1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685318", "l": "BCDX2 complex formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66372", "l": "H2O + sn-glycerol 3-phosphate = glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32294", "l": "phosphoethanolamine + 3 S-adenosyl-L-methionine <=> 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19580", "l": "luteolin + UDP-alpha-D-glucose <=> H(+) + luteolin 7-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.843050782660015", "identifiers": [{"i": "GO:0016247", "l": "channel regulator activity", "d": ["Binds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65769", "l": "a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59764", "l": "L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70530", "l": "H(+) + N-acyl-3-oxosphinganine + NADH <=> an N-acylsphinganine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58868", "l": "24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}, {"i": "EC:1.14.18.11", "l": "\"plant 4alpha-monomethylsterol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9006873", "l": "IL21 receptor STAT binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432148", "l": "Fgr may phosphorylate p38 MAPK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50638", "l": "a 2-(omega-methylsulfanyl)alkylmaleate + H2O => a 3-(omega-methylsulfanyl)alkylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41781", "l": "beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692539", "l": "HRH1 binds HRH1 inverse agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14167", "l": "CoA + H(+) + N-acetyl-L-aspartate => acetyl-CoA + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72432", "l": "(E)-caffeate + ATP + H(+) => (E)-caffeoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299318", "l": "Activation of TASK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25667", "l": "(2E)-geranyl diphosphate => beta-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613207", "l": "EGR1 binds to the EGR1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103060", "l": "kaempferol 3-rhamnoside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol-3-rhamnoside + UDP-L-rhamnose <=> kaempferol-3-rhamnoside-7-rhamnoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006050", "l": "MECP2:SIN3A complex binds the promoter of the BDNF gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23122", "l": "a dipeptide(in) + ADP + H(+) + phosphate => a dipeptide(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031710", "l": "neuromedin B receptor binding", "d": ["Binding to a neuromedin B receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654514", "l": "KAL1 binds FGFR1c (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.53", "l": "\"[myosin-light-chain] phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668714", "l": "RAC1:GTP binds NOX1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72551", "l": "glutarate(out) + urate(in) = glutarate(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22814", "l": "5,10-methenyltetrahydrofolate + NADPH => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.42", "l": "\"branched-chain-amino-acid transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113429", "l": "Elongating transcript encounters a lesion in the template (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75015", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hexadecanoyloxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120233", "l": "prenyl-FMNH2 binding", "d": ["Binding to prenyl-FMNH2, a flavin mononucleotide obtained by prenylation of the N-10 position of FMNH2 followed by cyclisation. An essential cofactor for the decarboxylase enzymes UbiD and Fdc1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678517", "l": "Defective ABCB11 does not transport bile salts from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35034", "l": "L-serine(in) <=> L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781840", "l": "ERCC6 binds stalled RNA Pol II (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352961", "l": "dihydroxyacetone phosphate + glyceraldehyde 3-phosphate <=> fructose 1,6-bisphosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70843", "l": "L-arginine(in) + L-methionine(out) + Na(+)(out) = L-arginine(out) + L-methionine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046404", "l": "ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75822", "l": "(5Z,8Z)-octadecadienoate + O2 <=> (5S)-hydroperoxy-(6E,8Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16575", "l": "(R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate => 2-oxoglutarate + 4-(phosphooxy)-L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24397", "l": "scytalone => 1,3,8-trihydroxynaphthalene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73121", "l": "H(+) + kaempferol 7-methyl ether + S-adenosyl-L-homocysteine => kaempferol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22301", "l": "a flavonol + UDP-alpha-D-glucose => a flavonol 3-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66973", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose => alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48355", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690340", "l": "Defective ABCC6 does not transport organic anion from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57090", "l": "3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+) => an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.157169620444122", "identifiers": [{"i": "GO:0004364", "l": "glutathione transferase activity", "d": ["Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64029", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine => H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72079", "l": "3 Na(+)(out) + selenate(out) = 3 Na(+)(in) + selenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59864", "l": "(indol-3-yl)butanoate + ATP + L-glutamine = (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623643", "l": "RDH13 reduces atRAL to atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51291", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate <=> (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60783", "l": "2-oxoglutarate + gibberellin A15 + O2 <=> CO2 + gibberellin A24 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40118", "l": "H2O + hexanoyl-CoA <=> CoA + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68914", "l": "DNA polymerase alpha:primase binds at the origin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140660", "l": "cytoskeletal motor activator activity", "d": ["Binds to and increases the activity of a motor protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757688", "l": "SERPINA6 binds PREDN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0032182", "l": "ubiquitin-like protein binding", "d": ["Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.137", "l": "\"mannan exo-1,2-1,6-alpha-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050629", "l": "tetrachloroethene reductive dehalogenase activity", "d": ["Catalysis of the reaction: trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62810", "l": "2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694462", "l": "ABHD6,12 hydrolyse 3AG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42798", "l": "cholesteryl (9Z,12Z)-octadecadienoate + CoA => (9Z,12Z)-octadecadienoyl-CoA + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45750", "l": "(2E)-hexenoyl-CoA => (3Z)-hexenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49035", "l": "(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] <=> 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67158", "l": "(9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+) => 1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59850", "l": "(S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+) => (2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201515", "l": "Active ALK recruits PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16985", "l": "3-oxoadipate + NADP(+) = H(+) + maleylacetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806732", "l": "GNLY binds the bacterial cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48278", "l": "a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine => H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16038", "l": "phosphate + thymidine => 2-deoxy-alpha-D-ribose 1-phosphate + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35282", "l": "acetyl-CoA + hexadecanoyl-CoA <=> 3-oxooctadecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67014", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate => a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390930", "l": "5-HT2 receptor can bind serotonin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37643", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209815", "l": "Tyrosine is monoiodinated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53559", "l": "(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14473", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.93", "l": "\"very-long-chain enoyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57526", "l": "a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+) => a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419011", "l": "Transhomodimerization of Nectins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64363", "l": "(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 <=> (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625913", "l": "Hypochlorous acid (HOCL) reacts with Lys-monochloramine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67295", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one <=> (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37008", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373747", "l": "Phosphorylation of nephrin by FYN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73228", "l": "(3R)-citramalate(in) + sulfate(out) => (3R)-citramalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50250", "l": "ADP-D-ribose + diphosphate => ATP + D-ribose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047207", "l": "1,2-beta-fructan 1F-fructosyltransferase activity", "d": ["Catalysis of the reaction: [(1->2)-beta-D-fructosyl](n) + [(1->2)-beta-D-fructosyl](m) = [(1->2)-beta-D-fructosyl](n+1) + [(1->2)-beta-D-fructosyl](m-1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205286", "l": "GRB2:SOS interacts with p-KIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11894", "l": "H(+) + nororientaline + S-adenosyl-L-homocysteine => 6-O-methylnorlaudanosoline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16530", "l": "ADP + H(+) + sulfate => adenosine 5'-phosphosulfate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73715", "l": "ATP(in) + dATP(out) = ATP(out) + dATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73153", "l": "CoA(in) + FMN(out) => CoA(out) + FMN(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70510", "l": "LDH tetramer oxidises LACT to PYR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19542", "l": "L-glutamate 5-semialdehyde + NADP(+) + phosphate => H(+) + L-glutamyl 5-phosphate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64815", "l": "acetyl-CoA + S-(2-aminoethyl)-homocysteine <=> CoA + H(+) + S-(2-acetamidoethyl)-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73961", "l": "4-ethyl-2-methoxyphenol + NAD(+) => 2-methoxy-4-vinylphenol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58612", "l": "2 L-ascorbate + N-octanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3857336", "l": "CEBPB homodimerization (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18439", "l": "4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+) => 4-CDP-2-C-methyl-D-erythritol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9611721", "l": "β1-agonists bind ADRB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445448", "l": "HHIP binds Hedgehog (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140809", "l": "histone H4R3 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H4 L-arginyl (position 3)= histone H4 L-citrullyl (position 3) + NH4+, resulting in histone H4 citrullination at position 3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679239", "l": "ULK complex translocates to the ER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39272", "l": "(3R)-hydroxy-(15Z)-tetracosenoyl-CoA => (2E,15Z)-tetracosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052860", "l": "2'-deoxymugineic-acid 3-dioxygenase activity", "d": ["Catalysis of the reaction: 2'-deoxymugineic acid + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineic acid + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47418", "l": "a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+) => an NDP-alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0097108", "l": "hedgehog family protein binding", "d": ["Binding to a member of the hedgehog protein family, signaling proteins involved in development."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675417", "l": "PEBP1 binds activated RAF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605591", "l": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41554", "l": "diphosphate + ophiobolin F => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869568", "l": "NPM1 binds TFAP2A homodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-213406", "l": "Disassociation of PLC-gamma1 from LAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18333", "l": "ATP + oleandomycin = ADP + H(+) + oleandomycin 2'-O-phosphate", "d": []}, {"i": "EC:2.7.1.136", "l": "\"macrolide 2'-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391168", "l": "SIRP gamma binds CD47 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55098", "l": "(3S)-3-hydroxypentanoate + CoA + H(+) => (3S)-3-hydroxypentanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41211", "l": "(indol-3-yl)acetate + H(+) + NADH + O2 = 2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.235", "l": "\"indole-3-acetate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65754", "l": "(3R)-3-hydroxy-L-glutamate + CO2 + succinate => 2-oxoglutarate + L-glutamate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2870221", "l": "E-selectin binds E-selectin ligand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18291", "l": "H2O + oxaloacetate => (S,S)-tartrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12178", "l": "H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine => phenylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607023", "l": "factor IXa associates with cell membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-217255", "l": "FMO1:FAD N-oxidises TAM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63078", "l": "2-acetylphloroglucinol + 3 CO2 + 4 CoA => acetyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21021", "l": "5-O-(1-carboxyvinyl)-3-phosphoshikimate => chorismate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60434", "l": "AH2 + cannabichromenate => A + cannabigerolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013159", "l": "CDC42 GEFs activate CDC42 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665284", "l": "Resistant ERBB2 KD mutants do not bind lapatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016851", "l": "magnesium chelatase activity", "d": ["Catalysis of the reaction: ATP + H2O + Mg2+ + protoporphyrin IX = ADP + 3 H+ + Mg-protoporphyrin IX + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68479", "l": "a (2R)-2-hydroperoxy fatty acid + H(+) <=> a fatty aldehyde + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163432", "l": "cholesterol ester + H2O -> cholesterol + fatty acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611751", "l": "β1,2-agonists bind ADRB1,2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5660662", "l": "ASC binds Caspase-8 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54457", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987223", "l": "IL10RB binds TYK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40954", "l": "(2S)-2-acetamido-4-aminobutanoate + H2O <=> acetate + L-2,4-diaminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794357", "l": "SHANK proteins bind GKAPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811454", "l": "MAPKs phosphorylate PP2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937814", "l": "RUNX3 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75678", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate <=> (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32197", "l": "abieta-7,13-dien-18-al + H2O => abieta-7,13-dien-18,18-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15605", "l": "H2O + L-serine O-sulfate = H(+) + NH4(+) + pyruvate + sulfate", "d": []}, {"i": "EC:4.3.1.10", "l": "\"serine-sulfate ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39744", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50902", "l": "(10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate => 10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44599", "l": "a fatty acyl-[ACP] + H2O <=> a fatty acid + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46473", "l": "4alpha-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28993", "l": "N-acetylneuraminate(out) => N-acetylneuraminate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30235", "l": "H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62746", "l": "(S)-2-methylbutanoate + compactin diol lactone + H(+) => H2O + mevastatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678925", "l": "NR3C1 binds NR3C1 agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33431", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate = (3E)-2-oxohex-3-enedioate", "d": []}, {"i": "EC:5.3.2.6", "l": "\"2-hydroxymuconate tautomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20672", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21398", "l": "CO2 + Na(+)(out) + propanoyl-CoA => (S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11836", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114354", "l": "SMAC binds XIAP:Caspase-7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69297", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate => 3-hydroxypent-4-ene nitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210309", "l": "Interaction of DAP12 and KIR2DS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37891", "l": "aclacinomycin T + H2O = 15-demethylaclacinomycin T + methanol", "d": []}, {"i": "EC:3.1.1.95", "l": "\"aclacinomycin methylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016205", "l": "selenocysteine methyltransferase activity", "d": ["Catalysis of the reaction: selenocysteine + S-adenosyl-L-methionine = Se-methylselenocysteine + S-adenosyl-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40727", "l": "1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid = a 1-acylglycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110244", "l": "Excision of FapyG by OGG1 glycosylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30525", "l": "GDP + H(+) + oxidized coenzyme F420-2 + phosphate => GTP + L-glutamate + oxidized coenzyme F420-1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51156", "l": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9010872", "l": "SLIT2 binds Dystroglycan (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030957", "l": "Tat protein binding", "d": ["Binding to Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68610", "l": "Formation of ORC(2-5) complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30140", "l": "H2O + octadecanoyl-CoA => CoA + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34817", "l": "curcumin + 2 H(+) + 2 NADPH => 2 NADP(+) + tetrahydrocurcumin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015558", "l": "secondary active p-aminobenzoyl-glutamate transmembrane transporter activity", "d": ["Enables the transfer of p-aminobenzoyl-glutamate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. p-aminobenzoyl-glutamate is the anion of p-aminobenzoyl-glutamic acid."]}, {"i": "RHEA:35043", "l": "N-(4-aminobenzoyl)-L-glutamate(in) = N-(4-aminobenzoyl)-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.38", "l": "\"coagulation factor XIIa\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22150", "l": "a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin] => a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.15", "l": "\"nitrite reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2855047", "l": "Hydrolysis of internal thioester in C4b (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2169046", "l": "Degradation of TGF-beta receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38881", "l": "a fatty acid(out) => a fatty acid(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12454", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) => 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0000095", "l": "S-adenosyl-L-methionine transmembrane transporter activity", "d": ["Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism."]}, {"i": "REACT:R-HSA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655846", "l": "Expression of Mevalonate Kinase (MVK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700164", "l": "Active ALK phosphorylates FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39176", "l": "(3R)-hydroxyeicosanoyl-CoA => (2E)-eicosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43407", "l": "N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37172", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA => 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72345", "l": "methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + resorcinol => 3-methoxyphenol + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624985", "l": "CAV1 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46350", "l": "3-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032184", "l": "SUMO polymer binding", "d": ["Binding to a polymer of the small ubiquitin-like protein SUMO."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164617", "l": "Elongation of Extended Telomeric Chromosome End (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51160", "l": "cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21510", "l": "H(+) + hexadecanoate + retinol => all-trans-retinyl hexadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690493", "l": "RHOB binds effectors on endosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56433", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61772", "l": "rebaudioside E + UDP-alpha-D-glucose = H(+) + rebaudioside D + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60244", "l": "2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]", "d": []}, {"i": "EC:1.14.99.66", "l": "\"[histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.30", "l": "\"1,3-beta-oligoglucan phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50653", "l": "2-(3-methylsulfanyl)propylmalate => 2-(2-methylsulfanyl)propylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43097", "l": "guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182990", "l": "Sprouty sequesters CBL away from active EGFR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71543", "l": "5-hydroxymethyl-dUMP in DNA + ATP = 5-phosphomethyl-dUMP in DNA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13075", "l": "guanosine 3',5'-bis(diphosphate) + H(+) + phosphate => guanosine 3'-diphosphate 5'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9656244", "l": "DRD2 binds DA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39795", "l": "7beta-hydroxycholesterol(in) + ATP + H2O = 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72722", "l": "eIF2 activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210805", "l": "Removal of miRNA passenger strand (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52738", "l": "(Z)-glucobrassicin + adenosine 3',5'-bisphosphate + H(+) => (Z)-indolylmethyl desulfoglucosinolate + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400496", "l": "Signal peptidase hydrolyzes preproGIP to proGIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202291", "l": "Activation of Lck (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35707", "l": "(2S)-versicolorone + H(+) + NADPH + O2 = (3S)-versiconol acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24459", "l": "alpha-ribazole 5'-phosphate + H2O <=> alpha-ribazole + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16714", "l": "H2O + S-succinylglutathione => glutathione + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0016615", "l": "malate dehydrogenase activity", "d": ["Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.19", "l": "\"undecaprenyl-diphosphooligosaccharide--protein glycotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15364", "l": "a dolichyl phosphate + UDP-alpha-D-xylose <=> a dolichyl D-xylosyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57104", "l": "[(1->4)-alpha-D-galacturonosyl](n) = 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)", "d": []}, {"i": "EC:4.2.2.9", "l": "\"pectate disaccharide-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20023", "l": "amidinoproclavaminate + CO2 + succinate => 2-oxoglutarate + deoxyamidinoproclavaminate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-912627", "l": "CBL ubiquitinates PI3K (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727188", "l": "ATP4A:ATP4B binds PPIs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40982", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134914", "l": "Beta-catenin migrates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9659820", "l": "RB1 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2186780", "l": "Degradation of Ub-SMAD7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45199", "l": "5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein] <=> 5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42588", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692749", "l": "CDC14A,B bind MAPK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70213", "l": "(S)-2-hydroxyglutarate + GDP-D-glycero-4-keto-alpha-D-lyxo-heptose => 2-oxoglutarate + GDP-D-glycero-alpha-D-manno-heptose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-378975", "l": "Follitropin is a heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67828", "l": "a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788999", "l": "HV1-mediated H+ transfer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692880", "l": "HRH3 binds Hist (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18044", "l": "2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin] <=> 8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101016", "l": "FMN-binding domain binding", "d": ["Binding to the FMN-binding domain of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.147", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913374", "l": "Phosphorylated SHC1 recruits SHIP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.124", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047563", "l": "3-hydroxybenzoate 2-monooxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxybenzoate + AH(2) + O2 = 2,3-dihydroxybenzoate + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41426", "l": "formate + grixazone A + H(+) + 3 H2O => 2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395517", "l": "NADPH transfers electrons to FDXR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73215", "l": "sulfate(out) + thiosulfate(in) = sulfate(in) + thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38861", "l": "bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP => beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74059", "l": "PDE6 hydrolyses cGMP to GMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827872", "l": "Expression of PRDM1 in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047686", "l": "arylsulfate sulfotransferase activity", "d": ["Catalysis of the reaction: an aryl sulfate + a phenol = a phenol + an aryl sulfate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102257", "l": "1-16:0-2-18:2-phosphatidylcholine sn-1 acylhydrolase activity", "d": ["Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O <=> 1-linoleoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018503", "l": "trans-1,2-dihydrodiolphenanthrene dehydrogenase activity", "d": ["Catalysis of the reaction: trans-1,2-dihydrodiolphenanthrene + NAD+ = H+ + NADH + 1,2-dihydroxyphenanthrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69403", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA <=> an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.40", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38294", "l": "(S)-malyl-CoA + H2O <=> (S)-malate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40349", "l": "acetyl-CoA + dodecanedioyl-CoA => 3-oxotetradecanedioyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61890", "l": "diosgenin 3-O-beta-D-glucoside + H(+) + UDP => diosgenin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60358", "l": "anthranilate + H(+) + octanoate => H2O + N-octanoylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30096", "l": "(S)-malate + a menaquinone => a menaquinol + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72391", "l": "2 hydrogencarbonate(out) + oxalate(in) = 2 hydrogencarbonate(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4086410", "l": "CDK1 phosphorylates BORA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14893", "l": "D-ornithine = (2R,4S)-2,4-diaminopentanoate", "d": []}, {"i": "EC:5.4.3.5", "l": "\"D-ornithine 4,5-aminomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374919", "l": "Noradrenaline clearance from the synaptic cleft (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682377", "l": "LC3 de-lipidation by ATG4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203130", "l": "OLR1 binds to oxidized LDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140620", "l": "DNA strand exchange inhibitor activity", "d": ["Binds to and stops, prevents or reduces a DNA strand exchange activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29809", "l": "ADP + H(+) + L-leucine(in) + phosphate => ATP + H2O + L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75891", "l": "Abortive Initiation After Second Transition (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30101", "l": "2-demethylmenaquinol-8 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655301", "l": "Activated FGFR2 mutants phosphorylate PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38747", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33976", "l": "DIMBOA beta-D-glucoside + H2O => D-glucose + DIMBOA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54658", "l": "(2E)-geraniol => linalool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944250", "l": "Association of procollagen type XXV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34470", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + valerena-4,7(11)-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23786", "l": "(S)-1-pyrroline-5-carboxylate + a quinol + H(+) => a quinone + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62457", "l": "ATP + H(+) + L-glutamate => diphosphate + L-glutamyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25697", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34827", "l": "H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2 = H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762246", "l": "ANGPTL4 binds CDH11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605591", "l": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009485", "l": "IL34:CSF1 binds CSF1R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74723", "l": "Endosome acidification (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60669", "l": "(R,R)-chrysanthemol + NAD(+) => (1R,3R)-chrysanthemal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265456", "l": "NPC1L1 binds ezetimibe (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099618", "l": "UDP-glucuronic acid dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-glucuronate + NAD+ = UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061655", "l": "Pup conjugating enzyme activity", "d": ["Isoenergetic transfer of Pup from one protein to another via the reaction X-Pup + Y = Y-Pup + X, where both the X-Pup and Y-Pup linkages are thioester bonds between the C-terminal amino acid of Pup and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41277", "l": "eicosanoate + sphing-4-enine => H2O + N-eicosanoyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419351", "l": "PAF receptor binds platelet activating factor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.396", "l": "\"bacteriochlorophyllide-a dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33627", "l": "ATP + CoA + decanoate = AMP + decanoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22574", "l": "AH2 + formaldehyde + L-glutamate => A + H2O + N-methyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44295", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17121", "l": "carbamoyl phosphate + L-lysine = H(+) + L-homocitrulline + phosphate", "d": []}, {"i": "EC:2.1.3.8", "l": "\"lysine carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690701", "l": "SHP1 binds p-CD22 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15031", "l": "D-mannose + H(+) + NADH => D-mannitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67258", "l": "2 H(+) + NADH + propanoate => H2O + NAD(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192061", "l": "CYP46A1 24-hydroxylates CHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60987", "l": "16-hydroxyhexadecanoate + NAD(+) <=> 16-oxohexadecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55823", "l": "a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40770", "l": "(20S)-ginsenoside R1 + H2O <=> (20S)-ginsenoside Rg1 + D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37106", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O <=> (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45686", "l": "N-dodecanoyl-sphing-4-enine-1-phosphate(out) => N-dodecanoyl-sphing-4-enine-1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58969", "l": "1-naphthaldehyde + H2O + O2 => 1-naphthoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001872", "l": "(1->3)-beta-D-glucan binding", "d": ["Binding to a (1->3)-beta-D-glucan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32944", "l": "a 1,2-diacyl-sn-glycerol + CDP-ethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450063", "l": "Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419389", "l": "LPA-binding receptors bind LPA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660890", "l": "Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61304", "l": "N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose = H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28963", "l": "H(+)(out) + L-proline(out) = H(+)(in) + L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0003923", "l": "GPI-anchor transamidase activity", "d": ["Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor."]}, {"i": "REACT:R-HSA-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.50", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033520", "l": "TYSND1 cleaves TYSND1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66012", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen] = [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981657", "l": "IL34 dimer binds PTPRZ1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40881", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65810", "l": "dec-9-ynoyl-[ACP] + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => decanoyl-[ACP] + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803719", "l": "TP53 binds ZNF385A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47015", "l": "[DsrC protein]-disulfide + H(+) + hydrogen sulfide <=> [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17625", "l": "D-lysopine + H2O + NADP(+) = H(+) + L-lysine + NADPH + pyruvate", "d": []}, {"i": "EC:1.5.1.16", "l": "\"D-lysopine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42892", "l": "5'-deoxyadenosine + H(+) + H2O = 5'-deoxyinosine + NH4(+)", "d": []}, {"i": "EC:3.5.4.41", "l": "\"5'-deoxyadenosine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008997", "l": "ribonuclease R activity", "d": ["Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37545", "l": "2-amino-5-chloromuconate 6-semialdehyde => 2-amino-5-chlorophenol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149519", "l": "MMACHC decyanates CNCbl (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61372", "l": "4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O = 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61723", "l": "a D-guloside + NAD(+) <=> a 3-dehydro-D-guloside + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014294", "l": "RAC2 binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70819", "l": "L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71625", "l": "malonate(in) + phosphate(out) => malonate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.233323709485049", "identifiers": [{"i": "GO:0016775", "l": "phosphotransferase activity, nitrogenous group as acceptor", "d": ["Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66067", "l": "2-oxohexanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204863", "l": "Interaction of Tie2 with Ang2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33322", "l": "a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75851", "l": "all-trans-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45019", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine <=> L-selenomethionine + tetrahydropteroyltri-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22940", "l": "ATP + L-arginine = ADP + H(+) + N(omega)-phospho-L-arginine", "d": []}, {"i": "EC:2.7.3.3", "l": "\"arginine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68532", "l": "(2E,6E)-farnesyl diphosphate = (Z)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433395", "l": "Dimerization of sSCF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66335", "l": "L-aspartate(out) <=> L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034848", "l": "naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity", "d": ["Catalysis of the reaction: naphthyl-2-oxomethyl-succinyl-CoA + CoASH = 2-naphthoyl-CoA + succinyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73812", "l": "L-proline(in) => L-proline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52919", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374899", "l": "Release of noradrenaline  at the synapse (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66122", "l": "(2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate => 2-oxobutanoate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008912", "l": "lactaldehyde reductase activity", "d": ["Catalysis of the reaction: propane-1,2-diol + NAD+ = lactaldehyde + NADH + H+."]}, {"i": "EC:1.1.1.77", "l": "\"lactaldehyde reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60431", "l": "(indol-3-yl)acetyl-L-aspartate + H2O <=> (indol-3-yl)acetate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26420", "l": "(2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal => (3R)-3-hydroxy-8'-apo-beta-carotenal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46769", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76426", "l": "N-atom dealkylation of caffeine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2660815", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17415", "l": "an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671919", "l": "Activated CIT phosphorylates MRLCs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48300", "l": "H2O + prostaglandin F2alpha 1-glyceryl ester = glycerol + H(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70600", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47555", "l": "glycodeoxycholate + H2O <=> deoxycholate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170120", "l": "Translocation of Cdc25B to the cytoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57295", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O <=> a guanosine in RNA + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39598", "l": "(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH <=> (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32767", "l": "cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65379", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47224", "l": "dehydroepiandrosterone 3-sulfate + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19390", "l": "(E)-ferulate + ATP + CoA => (E)-feruloyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45905", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine => dTDP + epivancomycin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.5.-", "l": "\"Thiosulfotransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61162", "l": "H(+) + quercitrin + UDP => quercetin + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49288", "l": "(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.1.20", "l": "\"lipoate--protein ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876484", "l": "NPC2 transfers CHOL to NPC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372742", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2731141", "l": "Syndecan-1 binds fibronectin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-481009", "l": "Exocytosis of platelet dense granule content (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769235", "l": "MAGED1 binds NPAS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004076", "l": "biotin synthase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102621", "l": "emindole-SB NADPH:oxygen oxidoreductase (14,15-epoxidizing) activity", "d": ["Catalysis of the reaction: emindole-SB + O2 + NADPH + H+ <=> 14,15-epoxyemindole-SB + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24112", "l": "2 glutathione + O2 = glutathione disulfide + H2O2", "d": []}, {"i": "EC:1.8.3.3", "l": "\"glutathione oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19393", "l": "L-lysine + pyruvate = (S)-2-amino-6-oxohexanoate + L-alanine", "d": []}, {"i": "EC:2.6.1.71", "l": "\"lysine--pyruvate 6-transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48160", "l": "3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] = epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177926", "l": "Dephosphorylation of PAG by SHP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53530", "l": "1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.25", "l": "\"bacteriophage T4 restriction endoribonuclease RegB\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50655", "l": "2-(3-methylsulfanyl)propylmalate <=> 2-(2-methylsulfanyl)propylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047897", "l": "formate-dihydrofolate ligase activity", "d": ["Catalysis of the reaction: 7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2467775", "l": "Autocleavage of ESPL1 (Separase) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25076", "l": "(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33761", "l": "a 3-hydroxy-fatty acyl-CoA + NADP(+) => a 3-oxo-fatty acyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67170", "l": "3-(3-hydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + 3-hydroxy-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40372", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP => 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29874", "l": "ATP + H2O + thiosulfate(out) <=> ADP + H(+) + phosphate + thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12350", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate => (S)-muconolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69385", "l": "(R)-carnitine + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) => (3R)-4-(dimethylamino)-3-hydroxybutanoate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66846", "l": "asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851890", "l": "MET phosphorylates SHC1-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55574", "l": "4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine => 4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49889", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71164", "l": "homogentisate + O2 => maleylacetoacetate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018725", "l": "trans-3,4-dihydrodiolphenanthrene sulfotransferase activity", "d": ["Catalysis of the reaction: trans-3,4-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-3,4-dihydrodiolsulfate conjugate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46439", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28160", "l": "alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73073", "l": "genkwanin + H(+) + S-adenosyl-L-homocysteine => apigenin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26120", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29162", "l": "3 a menaquinol(in) + 2 H(+)(out) + nitrite(out) <=> 3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821368", "l": "AKAP8L binds MLL1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50736", "l": "a quinone + 2 H(+) + hydrogen sulfide + sulfite = a quinol + thiosulfate", "d": []}, {"i": "EC:1.8.5.5", "l": "\"thiosulfate reductase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106376", "l": "2-hydroxyphytanoyl-CoA lyase activity", "d": ["Catalysis of the reaction: 2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA."]}, {"i": "RHEA:25355", "l": "2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25449", "l": "(2E,6E)-farnesyl diphosphate => (+)-guaia-6,9-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32354", "l": "3 S-adenosyl-L-methionine + tricetin <=> 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.145", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58979", "l": "H2O + malonaldehyde + O2 <=> 3-oxopropanoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191299", "l": "Squalene is oxidized to its epoxide (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11154", "l": "2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+) => 5-pyridoxate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14858", "l": "(indol-3-yl)acetate + ATP + L-lysine => ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36726", "l": "2-phenylethylamine + A + H2O <=> 2-phenylacetaldehyde + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193068", "l": "CYP17A1 17-hydroxylates PREG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68491", "l": "(2R)-2-hydroperoxytetradecanoate + H(+) <=> CO2 + H2O + tridecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603108", "l": "Defective MAOA does not oxidatively deaminate 5HT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19737", "l": "4-(gamma-L-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate", "d": []}, {"i": "EC:3.5.1.94", "l": "\"gamma-glutamyl-gamma-aminobutyrate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56885", "l": "adenosine(32) in tRNA + S-adenosyl-L-methionine => 2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60805", "l": "2-oxoglutarate + gibberellin A19 + O2 => CO2 + gibberellin A17 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.8.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12574", "l": "adenosylcob(III)inamide + ADP + H(+) + phosphate => (R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20739", "l": "acetyl-CoA + glycine <=> (2S)-2-amino-3-oxobutanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64615", "l": "ATP + L-glutamate + tRNA(Gln) <=> AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606622", "l": "GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23294", "l": "ADP + H(+) + N-phospho-L-lombricine => ATP + L-lombricine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69089", "l": "butanal + H2O + NAD(+) => butanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010177", "l": "2-(2'-methylthio)ethylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxo-4-methylthiobutanoate + acetyl-CoA + H2O = 2-(2'-methylthio)ethylmalic-acid + coenzyme A + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140855", "l": "histone H3S57 kinase activity", "d": ["Catalysis of the reaction: histone H3-serine (position 57) + ATP = histone H3-phosphoserine (position 57) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 57 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65219", "l": "3-oxododecanoyl-CoA + H2O <=> 3-oxododecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47641", "l": "adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52256", "l": "a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426032", "l": "DAG is metabolized by DAGL to 2-AG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349404", "l": "CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43462", "l": "4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA => dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21384", "l": "L-phenylalanine = (E)-cinnamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57474", "l": "1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP => (E)-4-coumarate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814555", "l": "Integrator complex processes the 3' end of snRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37109", "l": "N(7)-methylguanosine + phosphate => H2O + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17789", "l": "(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine = (S)-reticuline + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.116", "l": "\"3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0008200", "l": "ion channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of an ion channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37020", "l": "A + D-serine + H2O => 3-hydroxypyruvate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601897", "l": "MeR-PIWIL4:2'-O-methyl-piRNA:TDRD9:MAEL:TDRKH dissociates and MeR-PIWIL4:2'-O-methylpiRNA, TDRD9, MAEL translocate from cytosol to nucleus in an unknown association and order of events (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64287", "l": "2-phenylethylamine + pyruvate <=> 2-phenylacetaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62653", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA => 6 CO2 + 7 CoA + H2O + naphtopyrone YWA1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59686", "l": "D-maltohexaono-1,5-lactone + H2O2 => D-maltohexaose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23864", "l": "4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP", "d": []}, {"i": "EC:4.6.1.12", "l": "\"2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43984", "l": "(2E,6E)-farnesol + H(+) + NADPH + O2 = (2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047932", "l": "glucosamine N-acetyltransferase activity", "d": ["Catalysis of the reaction: D-glucosamine + acetyl-CoA = N-acetyl-D-glucosamine + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26242", "l": "geranylgeranyl diphosphate => diphosphate + elisabethatriene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0070818", "l": "protoporphyrinogen oxidase activity", "d": ["Catalysis of the reaction: protoporphyrinogen IX + acceptor = protoporphyrin IX + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54672", "l": "(+)-kolavenyl diphosphate + H2O = (+)-kolavelool + diphosphate", "d": []}, {"i": "EC:3.1.7.12", "l": "\"(+)-kolavelool synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72850", "l": "adenosine 3',5'-bisphosphate(in) + ADP(out) <=> adenosine 3',5'-bisphosphate(out) + ADP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665871", "l": "ADRM1 binds 26S proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627107", "l": "XIAP binds CASP7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52626", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate => [amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53285", "l": "NAD(+) + scyllo-inosose => 3-dehydro-scyllo-inosose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102745", "l": "dihydrogeranylgeranyl-PP reductase activity", "d": ["Catalysis of the reaction: H+ + dihydrogeranylgeranyl-PP + NADPH = tetrahydrogeranylgeranyl-PP + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35893", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449087", "l": "CD4 binds Interleukin-16 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654571", "l": "Activated FGFR1 binds FRS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730862", "l": "Autophosphorylation of LYN kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44142", "l": "acetyl-CoA + CO2 + reduced [flavodoxin] => CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62443", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) <=> 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64618", "l": "(E)-coniferyl acetate + CoA => (E)-coniferol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395412", "l": "Phosphorylation of SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50488", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047654", "l": "alliin lyase activity", "d": ["Catalysis of the reaction: an S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44144", "l": "acetyl-CoA + L-methionine = CoA + H(+) + N(alpha)-acetyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187332", "l": "Cytosolic CMs translocate to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400204", "l": "PPARA binds RXRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828100", "l": "Expression of SOX17 in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68971", "l": "mandelate + O2 <=> H2O2 + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72092", "l": "(R)-carnitine(out) + Na(+)(out) => (R)-carnitine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16491", "l": "D-glucose + mandelonitrile => (R)-prunasin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72606", "l": "(E)-sinapate + ATP + H(+) <=> (E)-sinapoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001039", "l": "RNA polymerase III hybrid type promoter sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193636", "l": "p75NTR interacts with the NOGO receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44804", "l": "1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) = 2-demethylmenaquinol-9 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37425", "l": "aclacinomycin A + H2O2 => aclacinomycin N + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65132", "l": "2-oxoglutarate + O2 + preaustinoid A1 = CO2 + H2O + preaustinoid A2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797553", "l": "Protein 4.1 binds CASK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60579", "l": "coenzyme M + methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] <=> Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044018", "l": "histone H3K36 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 36) = CoA + histone H3 N6-acetyl-L-lysine (position 36)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47888", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57439", "l": "guaethol + O2 + reduced [NADH--hemoprotein reductase] <=> acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008506", "l": "sucrose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57148", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72932", "l": "O2 + proatranorin IV + reduced [NADPH--hemoprotein reductase] => atranorin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112755", "l": "SOCS3 binds IL6ST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51584", "l": "4-(trimethylamino)butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.13", "l": "\"crotonobetainyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71970", "l": "(S)-2-hydroxyglutarate(out) + 3 Na(+)(out) <=> (S)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375161", "l": "NCAM1 trans-homophilic interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166363", "l": "TRAF6 binds to hp- IRAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73763", "l": "2 ATP + L-alanine + L-tryptophan = 2 ADP + cyclo(L-tryptophyl-L-alanyl) + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389463", "l": "Proteinase-activated receptors can bind thrombin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012556", "l": "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60088", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) = a 4alpha-methyl-3-oxosteroid + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68258", "l": "L-cystine(out) + Na(+)(out) => L-cystine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1067659", "l": "Assembly of hexameric IL-6 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23543", "l": "ATP + L-glutamate + tRNA(Glu) <=> AMP + diphosphate + L-glutamyl-tRNA(Glu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25186", "l": "1,2-dichloroethane + H2O => 2-chloroethanol + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11158", "l": "3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+) => H2O + L-valine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993802", "l": "HLCS biotinylates PC:Mn2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42338", "l": "[thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin] => [thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54287", "l": "H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-octadecanoylsphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983307", "l": "IL15 binds IL15RA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.4.1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008970", "l": "phospholipase A1 activity", "d": ["Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862733", "l": "CCR2, CCR3 bind CCL13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64092", "l": "3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 = 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69563", "l": "D-mannose(out) + H(+)(out) <=> D-mannose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.24", "l": "\"hydroxyacid-oxoacid transhydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54805", "l": "2 4-sulfanylbutanoate + NAD(+) => 4,4'-disulfanyldibutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62178", "l": "alpha-D-glucose 1-phosphate + GMP + 2 H(+) => GDP-alpha-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47174", "l": "5alpha-cholest-8-en-3-one + CO2 + NADH => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68095", "l": "a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA <=> a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32760", "l": "L-lysine => (3R)-3-methyl-D-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50123", "l": "taurine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033788", "l": "leucoanthocyanidin reductase activity", "d": ["Catalysis of the reaction: (2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47337", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45841", "l": "(3R)-3-hydroxydecanoyl-CoA + NADP(+) => 3-oxodecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70327", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+) = 4-methylsulfanyl-2-oxobutanoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.428", "l": "\"4-methylthio 2-oxobutanoate reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72008", "l": "succinate(in) + urate(out) => succinate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35828", "l": "H2O + N(1)-aminopropylagmatine => spermidine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176956", "l": "Formation of GINS complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56708", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.171", "l": "\"beta-amyrin 16alpha-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35408", "l": "H2O + medicarpin => 4'-methoxyisoflavan-2',4,7-triol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2067713", "l": "GP369 inhibits activation of amplified FGFR2 signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32110", "l": "3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine <=> H(+) + pterostilbene + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008036", "l": "RUNX2 binds to HIVEP3 and WWP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418856", "l": "Activation of Rac1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18449", "l": "A + arsenite + H2O = AH2 + arsenate + H(+)", "d": []}, {"i": "EC:1.20.99.1", "l": "\"arsenate reductase (donor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60421", "l": "H2O + triglucosyl-enterobactin => [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933539", "l": "Recruitment of IKK complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10364", "l": "2-oxoglutarate + dodecanoyl-CoA + H2O = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.4", "l": "\"decylhomocitrate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031833", "l": "type 7 serotonin receptor binding", "d": ["Binding to a type 7 serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67926", "l": "3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP => 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70510", "l": "LDH tetramer oxidises LACT to PYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59729", "l": "(2R)-ethylmalonyl-CoA => (2S)-ethylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74695", "l": "(+)-exo-beta-bergamotene + O2 + reduced [NADPH--hemoprotein reductase] = (5R)-hydroxy-beta-trans-bergamotene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10910", "l": "adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate => 3'-phosphoadenylyl sulfate + glycolithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25271", "l": "(R)-adrenaline + H(+) + S-adenosyl-L-homocysteine => (R)-noradrenaline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865182", "l": "OTUD7A hydrolyses K11diUb (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29348", "l": "2 H(+)(in) + orotate(in) => 2 H(+)(out) + orotate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.110", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41472", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.123", "l": "\"oryzalexin D synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19607", "l": "a chlorophyllide + H(+) + phytol => a chlorophyll + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9696275", "l": "RND2 binds GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62516", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9611751", "l": "β1,2-agonists bind ADRB1,2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15773", "l": "ATP + dihydroxyacetone = ADP + dihydroxyacetone phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.29", "l": "\"glycerone kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54427", "l": "L-aspartyl-[protein] + NAD(+) <=> 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24595", "l": "CTP + H(+) + phosphoethanolamine <=> CDP-ethanolamine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730856", "l": "Autophosphorylation of PAK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36341", "l": "2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine => [sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-447130", "l": "Interleukin-23 binds interleukin-23 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424484", "l": "Phosphorylation of BTK by p-SYK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909720", "l": "IFN alpha/beta binds to IFNAR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018774", "l": "RHOBTB1 binds GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27421", "l": "(2E,6E)-farnesyl diphosphate = (3E,6E)-alpha-farnesene + diphosphate", "d": []}, {"i": "EC:4.2.3.46", "l": "\"alpha-farnesene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577259", "l": "MSH2 variant:MSH3-defective DNA mismatch repair (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69937", "l": "guanosine(in) + Na(+)(in) => guanosine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33053", "l": "betaine aldehyde + H(+) + NADH => choline + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381644", "l": "ER calcium channels open in response to activated PKA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48259", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11188", "l": "3-cyano-L-alanine + 2 H2O = L-aspartate + NH4(+)", "d": []}, {"i": "EC:3.5.5.4", "l": "\"cyanoalanine nitrilase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37059", "l": "adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA", "d": []}, {"i": "EC:2.3.1.234", "l": "\"N(6)-L-threonylcarbamoyladenine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.16", "l": "\"2',3'-cyclic-nucleotide 2'-phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102303", "l": "resveratrol 3,5-O-dimethyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + trans-resveratrol <=> 2 S-adenosyl-L-homocysteine + pterostilbene + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31133", "l": "(6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide => 5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665748", "l": "FMNL2 binds RHOC:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42809", "l": "2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-L-Glu)(n) => 3 reduced coenzyme F420-(gamma-L-Glu)(n) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25357", "l": "2,6,10,14-tetramethylpentadecanal + formyl-CoA => 2-hydroxyphytanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972956", "l": "POU5F1 (OCT4), SOX2, NANOG bind the STAT3 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008479", "l": "tRNA-guanosine(34) queuine transglycosylase activity", "d": ["Catalysis of the reaction: guanosine34 in tRNA + queuine = guanine + queuosine34 in tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72674", "l": "6-hydroxyphenazine-1-carboxylate + 2 H(+) + NADH + O2 <=> 1,6-dihydroxyphenazine + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707594", "l": "Hemes bind LY96 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21600", "l": "anthranilate + benzoyl-CoA = CoA + N-benzoylanthranilate", "d": []}, {"i": "EC:2.3.1.144", "l": "\"anthranilate N-benzoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191656", "l": "Closure of gap junction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26258", "l": "dehydroabietadienol + H(+) + NADPH + O2 => dehydroabietadienal + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64080", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O = 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39564", "l": "(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH => (23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47327", "l": "(S)-3-amino-3-phenylpropanoate + pyruvate <=> 3-oxo-3-phenylpropanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52667", "l": "a short-chain (3S)-3-hydroxyacyl-CoA <=> a short-chain (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66665", "l": "ATP + coproporphyrin III(in) + H2O => ADP + coproporphyrin III(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687097", "l": "p-S857 NCOA3 binds ETV4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54587", "l": "a guanosine in 18S rRNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672817", "l": "Active MTORC1 binds the ULK1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59029", "l": "(Z)-24-ethylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420274", "l": "GIP receptor binds gastric inhibitory peptide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33668", "l": "H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2 => H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62406", "l": "CO2 + H2O + pentadecanoate => (R)-2-hydroxyhexadecanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983424", "l": "Budding of COPII coated vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.12", "l": "\"alpha-lytic endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17180", "l": "(R)-carnitine + octanoyl-CoA <=> CoA + O-octanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29539", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}, {"i": "EC:2.4.1.261", "l": "\"dolichyl-P-Man:Man8GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112385", "l": "Addition of nucleotides leads to transcript elongation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358545", "l": "EXO1 interacts with MSH2:MSH3 (MutSbeta) and MLH1:PMS2 (MutLalpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70692", "l": "ornithine => putrescine + CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018392", "l": "glycoprotein 3-alpha-L-fucosyltransferase activity", "d": ["Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75172", "l": "Formation of RAD50:MRE11 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24058", "l": "myo-inositol + phosphate => a myo-inositol phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390663", "l": "ADRA2A,B,C bind ADR,NAd (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15979", "l": "4-hydroxybenzaldehyde + hydrogen cyanide => (S)-4-hydroxymandelonitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66375", "l": "H2O + sn-glycerol 3-phosphate <=> glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.-.-", "l": "\"Acting on ester bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61080", "l": "(+)-minovincinine + acetyl-CoA = (+)-echitovenine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111870", "l": "Activation of PLC beta-1/4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852552", "l": "MST1R autophosphorylates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33562", "l": "an acyl-CoA + sn-glycerol 3-phosphate <=> a 2-acyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.34", "l": "\"trans-feruloyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36448", "l": "ATP + glycyl-L-proline(out) + H2O => ADP + glycyl-L-proline(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814831", "l": "TBC1D20 binds RAB1:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12528", "l": "N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate = [hyaluronan](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18467", "l": "5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+) => L-dopa + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10169", "l": "15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] => biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24723", "l": "H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 => H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013009", "l": "RHOA binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877361", "l": "Pyrin binds ASC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16784", "l": "a fatty acyl-CoA + H2O <=> a fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22162", "l": "a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA => 4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67486", "l": "a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679029", "l": "C-ter TLR7 dimer binds HCQ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23493", "l": "UDP-alpha-D-glucosamine => UDP-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047176", "l": "beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase activity", "d": ["Catalysis of the reaction: 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13105", "l": "glycerol 2-phosphate + H2O = glycerol + phosphate", "d": []}, {"i": "EC:3.1.3.19", "l": "\"glycerol-2-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67817", "l": "a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O => a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610745", "l": "SCF(beta-TrCP) ubiquitinates p-GLI2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14447", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54562", "l": "a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210439", "l": "glutamate uptake by astrocytes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18061", "l": "5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": []}, {"i": "EC:2.3.1.101", "l": "\"formylmethanofuran--tetrahydromethanopterin N-formyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64215", "l": "an N-(fatty acyl)-L-isoleucine + H2O <=> a fatty acid + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29634", "l": "D-maltotetraose + H2O <=> alpha-D-glucose + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0052673", "l": "prenol kinase activity", "d": ["Catalysis of the reaction: prenol + nucleoside triphosphate = prenyl phosphate + nucleoside diphosphate activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45364", "l": "H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine = (11Z)-eicosenoate + (4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52243", "l": "2 H2O + 2 Mn(2+) + O2 <=> 4 H(+) + 2 MnO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17439", "l": "(2E,4E)-2,4-dichloromuconate + H(+) => 2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156682", "l": "PLK1 phosphorylates NUDC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52673", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917987", "l": "TFRC dimer binds 2xholoTF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754964", "l": "ADA deamidates RBV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71338", "l": "chloride(out) + L-tryptophan(out) + 2 Na(+)(out) <=> chloride(in) + L-tryptophan(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34286", "l": "2 L-tyrosine + O2 <=> 2 L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40749", "l": "(3S)-3-hydroxy-L-lysine + CO2 + succinate => 2-oxoglutarate + L-lysine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30505", "l": "acetate + L-glutamate 5-semialdehyde => H2O + N-acetyl-L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.26", "l": "\"sterol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6790454", "l": "SUMOylation of XPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672178", "l": "PI3-kinase binds to PDGFRA extracellular domain dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672969", "l": "Phosphorylation of RAF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341669", "l": "Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797961", "l": "CHDH oxidises Cho to BETALD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813740", "l": "GDE1 hydrolyzes GroPIns (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38271", "l": "(3S)-citramalyl-CoA = 3-methylfumaryl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.153", "l": "\"3-methylfumaryl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016692", "l": "NADH peroxidase activity", "d": ["Catalysis of the reaction: H2O2 + NADH + H+ = 2 H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2197690", "l": "Detachment of WASP/WAVE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48284", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose = globoside NOR1 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70616", "l": "hexadecanoyl-[ACP] + L-lysyl-[protein] => H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429732", "l": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102496", "l": "GA5 2,3 epoxidase activity", "d": ["Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate <=> gibberellin A6 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034908", "l": "2-chloro-N-isopropylacetanilide 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + O2 + 2 H+ + NADH = 2-chloro-N-isopropylacetamide + catechol + NAD+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043814", "l": "phospholactate guanylyltransferase activity", "d": ["Catalysis of the reaction: 2-phospho-(S)-lactate + GTP = lactyl-2-diphospho-5'-guanosine + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58168", "l": "(2E,6E)-farnesyl diphosphate = (-)-5-epi-eremophilene + diphosphate", "d": []}, {"i": "EC:4.2.3.199", "l": "\"(-)-5-epieremophilene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380002", "l": "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32695", "l": "(2E)-geranyl diphosphate = (-)-car-3-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417842", "l": "P2Y10 receptor can bind to LPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210784", "l": "HNF1B-dependent synthesis of HNF6 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72722", "l": "eIF2 activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41393", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.68", "l": "\"t-plasminogen activator\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33993", "l": "alpha-copaene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17370", "l": "glycyrrhizin + H2O => 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73270", "l": "H(+)(out) + L-methionine(in) <=> H(+)(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-901047", "l": "Binding of ERp57 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20720", "l": "H2O + isopenicillin N + phenylacetyl-CoA = CoA + H(+) + L-2-aminoadipate + penicillin G", "d": []}, {"i": "EC:2.3.1.164", "l": "\"isopenicillin-N N-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299297", "l": "Activation of THIK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71845", "l": "tauroursodeoxycholate(in) => tauroursodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12660", "l": "a (2S)-2-methylacyl-CoA <=> a (2R)-2-methylacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662606", "l": "MT3 binds zinc (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61870", "l": "1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627107", "l": "XIAP binds CASP7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34701", "l": "(-)-alpha-isocomene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2168046", "l": "Collagen type XII degradation by MMP12 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034549", "l": "N-cyclopropylammelide alkylamino hydrolase activity", "d": ["Catalysis of the reaction: N-cyclopropylammelide + H2O = cyclopropylamine + cyanuric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607734", "l": "PKC-delta translocates to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690494", "l": "RHOB translocates to the endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17054", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate => beta-D-fructose 6-phosphate + D-erythrose 4-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004377", "l": "GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity", "d": ["Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65298", "l": "ethylacryloyl-CoA + reduced [electron-transfer flavoprotein] => (2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2995388", "l": "PP2A dephosphorylates BANF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034544", "l": "trans-ACOHDA hydrolase activity", "d": ["Catalysis of the reaction: trans-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate + H2O = fumarylpyruvate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450088", "l": "GLUT1 tetramer binds 4xATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23556", "l": "D-alanine + L-glutamine = gamma-L-glutamyl-D-alanine + NH4(+)", "d": []}, {"i": "EC:2.3.2.14", "l": "\"D-alanine gamma-glutamyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.-", "l": "\"With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16012", "l": "ATP + formate <=> ADP + formyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41801", "l": "acetyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210881", "l": "Dimerization of Tie2/Ang1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390909", "l": "HRH2 binds hist (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31321", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP => (2R)-3-phosphoglycerate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192061", "l": "CYP46A1 24-hydroxylates CHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727922", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to SMAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61481", "l": "a sphingoid base + a very long-chain fatty acyl-CoA => an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14906", "l": "5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate => 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42394", "l": "D-galactono-1,5-lactone + H(+) + NADH => D-galactose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984963", "l": "EBI3 gene transcription and translation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33981", "l": "D-glucose + DIBOA => DIBOA beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59160", "l": "ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20729", "l": "H2O + L-glutamate + O2 => 2-oxoglutarate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814674", "l": "Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102289", "l": "beta-amyrin 11-oxidase activity", "d": ["Catalysis of the reaction: beta-amyrin + 2 O2 + 2 NADPH + 2 H+ <=> 11-oxo-beta-amyrin + 3 H2O + 2 NADP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001222", "l": "transcription corepressor binding", "d": ["Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0086006", "l": "voltage-gated sodium channel activity involved in cardiac muscle cell action potential", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389463", "l": "Proteinase-activated receptors can bind thrombin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432164", "l": "Ca2+ influx into the post-synaptic cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-532549", "l": "MPI isomerises Fru6P to Man6P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57515", "l": "chlorobenzene + H(+) + NADH + O2 <=> (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806974", "l": "MET dimers autophosphorylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51956", "l": "(E)-2-methylpropanal oxime = (Z)-2-methylpropanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628807", "l": "Defective SLC29A3 does not transport nucleosides from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624954", "l": "INPP5E translocates to the primary cilium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787820", "l": "IL34 dimer binds CSF1R (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45385", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047404", "l": "glucuronosyl-disulfoglucosamine glucuronidase activity", "d": ["Catalysis of the reaction: H2O + 3-D-glucuronosyl-N2-,6-disulfo-beta-D-glucosamine = glucuronate + N2,6-disulfo-D-glucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782820", "l": "USP17 deubiquitinates SUDS3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17817", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0010465", "l": "nerve growth factor receptor activity", "d": ["Combining with nerve growth factor (NGF), to prevent apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17350", "l": "(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14931", "l": "androst-4-ene-3,17-dione + H(+) + NADH => NAD(+) + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68595", "l": "ORC2 binds ORC3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15982", "l": "H(+) + S-adenosyl-L-methionine => CO2 + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26552", "l": "(S)-piperazine-2-carboxylate + NH4(+) => (S)-piperazine-2-carboxamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74080", "l": "H(+) + menaquinone-4 + NADH => menaquinol-4 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59328", "l": "D-xylono-1,5-lactone + H2O = D-xylonate + H(+)", "d": []}, {"i": "EC:3.1.1.110", "l": "\"xylono-1,5-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047238", "l": "glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3858475", "l": "ppDVL recruits RAC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49483", "l": "2 H2O + L-1-piperideine-6-carboxylate + NADP(+) <=> H(+) + L-2-aminoadipate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433454", "l": "Phosphorylation of GAB2 by SFKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70407", "l": "[(2E,6E,10E)-geranylgeranyl]-L-cysteine + H2O + O2 = (2E,6E,10E)-geranylgeranial + H2O2 + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381466", "l": "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0000295", "l": "adenine nucleotide transmembrane transporter activity", "d": ["Enables the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0051880", "l": "G-quadruplex DNA binding", "d": ["Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75081", "l": "Formation of AT-AC B Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791016", "l": "SFTPB binds itself (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209815", "l": "Tyrosine is monoiodinated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55594", "l": "(3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP] => 2 (3R)-hydroxydecanoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446364", "l": "Migfilin interacts with VASP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20108", "l": "ADP + beta-D-fructose 6-phosphate <=> AMP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60608", "l": "1-tetradecanoyl-sn-glycero-3-phosphoethanolamine = 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351341", "l": "Exocytosis of Proactivator polypeptide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41982", "l": "5alpha-pregnane-3,20-dione + H(+) + NADH => 3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18856", "l": "NAD(+) + tartrate <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005335", "l": "serotonin:sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) + Cl-(out) = serotonin(in) + Na+(in)+ Cl-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13330", "l": "A + a 3-oxosteroid => a 3-oxo-Delta(1)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71419", "l": "3,3',5-triiodo-L-thyronine(out) + L-tyrosine(in) = 3,3',5-triiodo-L-thyronine(in) + L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848713", "l": "PTK6 binds BCAR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177926", "l": "Dephosphorylation of PAG by SHP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32340", "l": "(+)-thujan-3-ol + NADP(+) => (+)-thujan-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638137", "l": "EGFRvIII cancer variant does not bind EGF ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69252", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate = 2-(thiiran-2-yl)acetonitrile + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66371", "l": "6-methyl-3,7-dioxodecanedioyl-CoA + CoA <=> 4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13794", "l": "2-methyleneglutarate => 2-methylene-3-methylsuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66924", "l": "[(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA = [(R)-3-hydroxyalkanoate](n+1) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56937", "l": "17beta-hydroxy-androst-5-en-3-one => testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55953", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose => a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809309", "l": "MTMR6 binds MTMR9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27682", "l": "ATP + dTDP = ADP + dTTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10217", "l": "[DNA-directed RNA polymerase] + ATP => ADP + H(+) + phospho-[DNA-directed RNA polymerase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73820", "l": "choline(in) + 2 H(+)(out) => choline(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15707", "l": "2 a ubiquinol + phenylglyoxylyl-CoA => 2 a ubiquinone + H2O + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64817", "l": "5-aminolevulinate(in) => 5-aminolevulinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43010", "l": "2-aminoprop-2-enoate + H2O => D-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.938386572175233", "identifiers": [{"i": "GO:0004111", "l": "creatine kinase activity", "d": ["Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75565", "l": "cyathatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cyathadiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008953", "l": "penicillin amidase activity", "d": ["Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060228", "l": "phosphatidylcholine-sterol O-acyltransferase activator activity", "d": ["Binds to and increases the activity of phosphatidylcholine-sterol O-acyltransferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71367", "l": "epiandrosterone 3-sulfate(out) + 2 Na(+)(out) = epiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940100", "l": "CDK1 phosphorylates VCPIP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11349", "l": "arsenite(in) + ATP + H2O => ADP + arsenite(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31325", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+) => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17879", "l": "a guaiacol + H(+) + S-adenosyl-L-homocysteine => a catechol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110319", "l": "Elongation by POLH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52484", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A = (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014293", "l": "RAC2 GDIs block activation of RAC2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52211", "l": "alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000137", "l": "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788628", "l": "p-Y-STATs dissociate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609739", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2C (GRIN2C) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189488", "l": "UROS transforms HMB to URO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21450", "l": "16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate => 16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50665", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68544", "l": "(2Z,6Z)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622604", "l": "BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19886", "l": "(S)-reticuline + O2 => (S)-scoulerine + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198669", "l": "p38MAPK phosphorylates MSK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5631941", "l": "SESN1,2,3 bind AMPK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32728", "l": "a very-long-chain acyl-CoA + H(+) + malonyl-CoA => a very-long-chain 3-oxoacyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30416", "l": "H(+) + 2 NADPH + O2 + octadecanal => formate + H2O + heptadecane + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3797226", "l": "Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8980691", "l": "RHOA GEFs activate RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093332", "l": "p-EPHB phosphorylates SDC2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814153", "l": "ADO oxidises 2AET to HTAU (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56173", "l": "FMN + O2 => 8-demethyl-8-formylriboflavin 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17022", "l": "(2-aminoethyl)phosphonate + pyruvate => L-alanine + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22927", "l": "dCMP + H(+) + H2O <=> dUMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42864", "l": "norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + norspermine + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.126", "l": "\"norspermine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36386", "l": "carbamoyl adenylate + tobramycin <=> AMP + H(+) + nebramycin 5'", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990226", "l": "histone methyltransferase binding", "d": ["Binding to a histone methyltransferase enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2214351", "l": "PLK1 phosphorylates GORASP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26322", "l": "resorcinol + S-adenosyl-L-methionine => 3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008955", "l": "peptidoglycan glycosyltransferase activity", "d": ["Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983194", "l": "Kinesin-1 is a heterotetramer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20190", "l": "5,6-dihydrouracil + NAD(+) => H(+) + NADH + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48154", "l": "ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate => ganglioside GD1b(d18:1(4E)/18:0) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928645", "l": "EPHB:NMDAR binds TIAM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754964", "l": "ADA deamidates RBV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113402", "l": "Formation of DSIF:NELF:early elongation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41734", "l": "[(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->4)-alpha-D-glucosyl](n) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021596", "l": "Membrane estrogen receptors bind SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47361", "l": "decanoate ester + H2O => an aliphatic alcohol + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132047", "l": "Spontaneous hydrolysis of an internal thioester bond in complement factor C3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139941", "l": "Binding of IP3 to IP3 receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168870", "l": "Neuraminidase enzymatic release from sialic acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22120", "l": "CoA + GTP + succinate = GDP + phosphate + succinyl-CoA", "d": []}, {"i": "EC:6.2.1.4", "l": "\"succinate--CoA ligase (GDP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74062", "l": "beta-alanine(out) + L-alanine(in) <=> beta-alanine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63530", "l": "[thioredoxin]-disulfide + 2 H2O => [thioredoxin]-dithiol + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24019", "l": "16-epivellosimine + acetyl-CoA <=> CoA + vinorine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419843", "l": "CALCA(83-119) binds CALCR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3769401", "l": "DKK and KRM bind LRP5/6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139913", "l": "TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55103", "l": "3-oxopentanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxypentanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69276", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate = but-3-enenitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25543", "l": "ent-copalyl diphosphate <=> diphosphate + ent-pimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937419", "l": "CBR3 reduces DOX to DOXOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52110", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35495", "l": "H2O + N-(4-aminobenzoyl)-L-glutamate = 4-aminobenzoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18752", "l": "[protein]-dithiol + NAD(+) <=> [protein]-disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212614", "l": "Glutamine transport from astrocytes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824266", "l": "LEF1:CTNNB1, NICD1 (NOTCH1) and TBX6 bind the HES7 gene in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36873", "l": "3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA => (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853762", "l": "RET dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20635", "l": "a lyso-ornithine lipid + H(+) + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16345", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate", "d": []}, {"i": "EC:4.2.3.167", "l": "\"dolabella-3,7-dien-18-ol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29812", "l": "ATP + H2O + thiamine(out) => ADP + H(+) + phosphate + thiamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52232", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 = 3 A + Fe(2+) + 3 H2O + mycobilin a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75856", "l": "Abortive Initiation Before Second Transition (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25647", "l": "(R)-pulegone + H(+) + NADPH => (2R,5R)-isomenthone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52344", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418091", "l": "F2R binds ARRB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25154", "l": "3-phenylpyruvate + L-glutamate => 2-oxoglutarate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691154", "l": "HFE binds TFRC dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.172", "l": "\"3,5,6-trichloropyridin-2-ol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814764", "l": "Plasma membrane resorption (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0051010", "l": "microtubule plus-end binding", "d": ["Binding to the plus end of a microtubule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60582", "l": "18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55923", "l": "[cis-1,4-isoprene](n) + O2 <=> (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69654", "l": "cumene hydroperoxide + 2 glutathione <=> 2-phenylpropan-2-ol + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928591", "l": "EPH:EFN tetramers oligomerise (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67350", "l": "apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA => apigenin 7-O-beta-D-glucoside + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61243", "l": "H2O + L-phenylalanine + O2 <=> 3-phenylpyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903877", "l": "21-deoxycortisol binding", "d": ["Binding to 21-deoxycortisol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36702", "l": "3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP <=> 8-desmethylnovobiocic acid + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "54.245811769807808", "identifiers": [{"i": "GO:0005267", "l": "potassium channel activity", "d": ["Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68825", "l": "(2E)-geranyl diphosphate => (Z)-beta-ocimene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159868", "l": "Furin cleaves pro-factor VII to factor VII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66059", "l": "indole-3-pyruvate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65716", "l": "2-oxoglutarate + a primary linear alkyl sulfate ester + O2 = an aldehyde + CO2 + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782943", "l": "UV-DDB ubiquitinates XPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046180", "l": "KSPG is secreted from the cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043115", "l": "precorrin-2 dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + precorrin-2 = 2 H+ + NADH + sirohydrochlorin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41527", "l": "5 H(+) + 5 malonyl-CoA <=> 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60141", "l": "dodecanoyl-CoA + H(+) + malonyl-CoA => 3-oxotetradecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788611", "l": "HYKK phosphorylates 5HLYS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5444523", "l": "Formation of MSH1:PMS2 Complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0044325", "l": "transmembrane transporter binding", "d": ["Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13637", "l": "H(+) + methane + NADH + O2 = H2O + methanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166792", "l": "Conversion of C2 into C2a and C2b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102622", "l": "linuron hydrolase activity", "d": ["Catalysis of the reaction: linuron + H2O <=> N,O-dimethylhydroxylamine + carbon dioxide + 3,4-dichloroaniline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37244", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947538", "l": "Transfer of sulfur from MOCS3-S-S onto MOCS2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004181", "l": "metallocarboxypeptidase activity", "d": ["Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44592", "l": "3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.9.-.-", "l": "\"Acting on phosphorus-nitrogen bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18510", "l": "H(+) + H2O2 + NADH => 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14667", "l": "NH4(+) + xanthine => guanine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30373", "l": "(-)-geosmin + acetone => (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428749", "l": "Activated TP receptor binds G-proten Gq (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60129", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O => 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193703", "l": "IKKbeta is activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790907", "l": "Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389954", "l": "Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0031634", "l": "replication fork barrier binding", "d": ["Binding to replication fork barriers, sites that inhibit the progress of replication forks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49209", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60804", "l": "2-oxoglutarate + gibberellin A19 + O2 = CO2 + gibberellin A17 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112436", "l": "Formation of Elongin complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-421831", "l": "trans-Golgi Network Coat Assembly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51815", "l": "ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380272", "l": "Plk1-mediated phosphorylation of Nlp (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56354", "l": "3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+) => 4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3076905", "l": "Extracellular BTD hydrolyses BCTN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61728", "l": "a 3-dehydro-D-guloside = a 3-dehydro-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045507", "l": "interleukin-25 receptor activity", "d": ["Combining with interleukin-25 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71126", "l": "(E)-caffeate + ATP + H(+) + 2 malonyl-CoA <=> AMP + 2 CO2 + 2 CoA + diphosphate + hispidin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69911", "l": "adenosine(out) + 2 Na(+)(out) = adenosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48000", "l": "1,6-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55814", "l": "2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine => a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33393", "l": "C20 sphinganine + phosphate => C20 sphinganine 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52445", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose => 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141016", "l": "G/T mismatch-specific thymine-DNA glycosylase activity", "d": ["Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine and leaving an apyrimidinic (AP) site."]}, {"i": "EC:3.2.2.29", "l": "\"thymine-DNA glycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51632", "l": "all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28321", "l": "scutellarein + UDP-alpha-D-glucuronate <=> scutellarin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71365", "l": "17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in) => 17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49366", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate => 17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74325", "l": "O-3-hydroxybutanoyl-(R)-carnitine(out) => O-3-hydroxybutanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32097", "l": "CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+) => acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12939", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA => a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784734", "l": "PCSK9 binds LDLR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018622", "l": "4-chlorophenylacetate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: 4-chlorophenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56139", "l": "2 a phenolic donor + H2O2 <=> 2 a phenolic radical donor + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56163", "l": "an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate <=> an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856525", "l": "ANGPTL8 binds ANGPTL3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869560", "l": "The NOP2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23233", "l": "4 Fe(III)-[cytochrome c] + hydrazine => 4 Fe(II)-[cytochrome c] + 4 H(+) + N2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35222", "l": "8-oxo-dADP + H2O <=> 8-oxo-dAMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10006", "l": "benzyl thiocyanate => benzyl isothiocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-984689", "l": "Kinesin-7 is a dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12295", "l": "ATP + L-serine + tRNA(Ser) <=> AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161293", "l": "Tropoelastin forms aggregate globules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74740", "l": "Binding of SHC1 to insulin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31949", "l": "ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24512", "l": "L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O", "d": []}, {"i": "EC:4.2.1.50", "l": "\"pyrazolylalanine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41297", "l": "hexanoate + sphing-4-enine => H2O + N-(hexanoyl)sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32041", "l": "AMP + ATP + 2 H(+) => H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49539", "l": "2-amino-2-deoxy-D-gluconate <=> (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14229", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.5.7.1", "l": "\"methylenetetrahydrofolate reductase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47849", "l": "2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) => CO2 + diphosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71043", "l": "L-alanine(in) + L-phenylalanine(out) = L-alanine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22193", "l": "(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29040", "l": "ATP + H2O + L-aspartate(out) => ADP + H(+) + L-aspartate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20066", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 => 3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647660", "l": "GSDME (1-270) binds PIPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51146", "l": "(10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28470", "l": "pyridoxine(in) = pyridoxine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937177", "l": "AHR:TCDD binds ARNT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63119", "l": "peroxynitrite <=> nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46431", "l": "4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032442", "l": "phenylcoumaran benzylic ether reductase activity", "d": ["Catalysis of the NADPH-dependent 7-O-4' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction: dehydrodiconiferyl alcohol + NADPH + H+ = isodihydrodehydrodiconiferyl alcohol + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22918", "l": "4-acetoxyphenol + H2O + NADP(+) => 4'-hydroxyacetophenone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32577", "l": "(1R,5R)-alpha-pinene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.61", "l": "\"tubulin-glutamate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48983", "l": "3,4-dichlorocatechol + O2 <=> (2Z,4Z)-2,3-dichloromuconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68960", "l": "DNA polymerase epsilon binds at the origin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944099", "l": "Activated PPARG binds PTEN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429449", "l": "Syk activation leads to SLP-76 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71463", "l": "H2O + substance P = Gly-L-Leu-L-Met-NH2 + substance P(1-8)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22710", "l": "a carboxylate + glutathione + H(+) => H2O + S-acylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56578", "l": "globoside Gb4Cer + H(+) + UDP => globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18717", "l": "3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.84", "l": "\"methylquercetagetin 6-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35509", "l": "glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434073", "l": "IRAK4 recruitment to the activated TLR complexed with ligand, TIRAP and MyD88  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114683", "l": "Phosphorylation of Platelet Sec-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54054", "l": "diphosphate + tau-cadinol => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086223", "l": "Collagen type IX binds integrin alpha11beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44942", "l": "1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+) => 1-O-alkyl-2,3-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306876", "l": "NLRP3 activation by small molecules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19518", "l": "H2O + N,N-dimethylformamide => dimethylamine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68051", "l": "[protein]-D-aspartate + S-adenosyl-L-methionine <=> [protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64257", "l": "dodecanoyl-CoA + glycine => CoA + H(+) + N-dodecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13679", "l": "D-xylulose 5-phosphate => D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27777", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44562", "l": "4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-heptaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9659820", "l": "RB1 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417825", "l": "P2Y11 receptor can bind to ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102425", "l": "myricetin 3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: myricetin + UDP-alpha-D-glucose <=> myricetin 3-O-beta-D-glucopyranoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69856", "l": "a 5,6-dihydrouridine in mRNA + NADP(+) => a uridine in mRNA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52474", "l": "16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17beta-estriol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15160", "l": "4-hydroxyphenylacetate + H(+) + NADPH + O2 <=> H2O + homogentisate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53953", "l": "4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate => 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909780", "l": "(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374298", "l": "Opioid receptors bind opioid peptides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804402", "l": "TP53 binds POU4F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635859", "l": "GLI:SUFU dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482770", "l": "Release of platelet secretory granule components (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452338", "l": "Expression of TDGF1 (CRIPTO) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56884", "l": "adenosine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788999", "l": "HV1-mediated H+ transfer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35813", "l": "(-)-medicarpin + H2O => (3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66446", "l": "(E)-4-hexen-3-one + H(+) + NADPH => hexan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28743", "l": "nitrate(in) + nitrite(out) = nitrate(out) + nitrite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47637", "l": "H2O + L-arginine + NADP(+) => 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15729", "l": "D-mannonate + NAD(+) = H(+) + keto-D-fructuronate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31858", "l": "(S)-2,3-epoxysqualene <=> achilleol B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.108", "l": "\"protein adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14292", "l": "a dicarboxylate + ATP + CoA <=> AMP + diphosphate + omega-dicarboxyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866304", "l": "pre-VLDL binds lipids to form VLDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64298", "l": "(4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+) => (4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34309", "l": "2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite => 4-nitrocatechol + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450975", "l": "isocitrate <=> citrate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636564", "l": "SapM binds RAB7A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202328", "l": "Translocation of PKC theta to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052880", "l": "oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a copper protein."]}, {"i": "EC:1.10.9.-", "l": "\"With a copper protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183072", "l": "EGFR non-clathrin mediated endocytosis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626938", "l": "Beta-catenin binds SOX proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202724", "l": "P-selectin binds P-selectin ligand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110218", "l": "Cleavage of uracil by TDG glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44244", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69324", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate = 4-methylsulfanylbutyl isothionate + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869542", "l": "TFPA2A homodimer and NPM1 bind the HSPD1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45462", "l": "a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine => H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2299620", "l": "Collagen XI cross-links with collagen II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71892", "l": "dGMP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-dGMP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2106615", "l": "Removal of siRNA passenger strand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72104", "l": "Na(+)(out) + O-propanoyl-(R)-carnitine(out) => Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70962", "l": "D-tyrosine + H2O + O2 <=> 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75943", "l": "beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18400", "l": "ATP + L-glutamate + tRNA(Glx) <=> AMP + diphosphate + L-glutamyl-tRNA(Glx)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18838", "l": "10-deacetyltaxuyunnanin C + acetyl-CoA => CoA + taxuyunnanin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27431", "l": "a 1,2-diacyl-sn-glycerol + phosphate => a 1,2-diacyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54007", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71108", "l": "L-leucine(out) + S-methylmercury-L-cysteine(in) => L-leucine(in) + S-methylmercury-L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75537", "l": "(R)-N-acetyl-S-methyl-L-cysteine sulfoxide + FMN + H(+) + H2O => FMNH2 + N-acetyl-S-methyl-L-cysteine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046978", "l": "TAP1 binding", "d": ["Binding to the TAP1 subunit of TAP (transporter associated with antigen processing) protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809680", "l": "MTMR12 binds MTM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14517", "l": "(E)-feruloyl-CoA + H2O = 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10634", "l": "D-mannuronate + H(+) + NADH => D-mannonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14978", "l": "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate => 3-carboxy-cis,cis-muconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6810376", "l": "ING2 binds PI5P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16276", "l": "an N-acylsphing-4-enine + CDP-choline <=> a sphingomyelin + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74410", "l": "2 (S)-lactate(in) + thromboxane B2(out) <=> 2 (S)-lactate(out) + thromboxane B2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60922", "l": "a cytidine in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72103", "l": "Na(+)(out) + O-propanoyl-(R)-carnitine(out) = Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944263", "l": "Association of procollagen type II (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.685364931984026", "identifiers": [{"i": "GO:0016405", "l": "CoA-ligase activity", "d": ["Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814734", "l": "CDSN binds the cornified envelope (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964274", "l": "G alpha (12) binds BTK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684351", "l": "pp1a cleaves itself (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39210", "l": "3-oxohexacosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyhexacosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20988", "l": "ATP + 2 H2O = AMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948775", "l": "MKRN1 polyubiquitinates PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2002460", "l": "P4HB binds Collagen chains (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50113", "l": "octadecanoyl-CoA + taurine => CoA + H(+) + N-octadecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17649", "l": "acetyl-[ACP] + malonate = acetate + malonyl-[ACP]", "d": []}, {"i": "EC:2.3.1.187", "l": "\"acetyl-S-ACP:malonate ACP transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193684", "l": "p62 recruits an atypical PKC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36907", "l": "(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA = (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017983", "l": "MECP2 binds CRH gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874184", "l": "CREB3L1 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0022858", "l": "alanine transmembrane transporter activity", "d": ["Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784861", "l": "HSPG binds LPL dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33052", "l": "choline + NAD(+) => betaine aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983142", "l": "Formation of peptide loading complex (PLC) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76013", "l": "(3R)-hydroxybutanoate trimer + (R)-3-hydroxybutanoate + H(+) => (3R)-hydroxybutanoate tetramer + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0016696", "l": "oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP."]}, {"i": "EC:1.12.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29673", "l": "Ca(2+)(out) => Ca(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62058", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45159", "l": "3-oxopropanoyl-CoA + H2O <=> 3-oxopropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31397", "l": "all-trans-4,4'-diapophytofluene + FADH2 => 15-cis-4,4'-diapophytoene + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44074", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-alkyl-2-acyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54744", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2172666", "l": "RB1 binds condensin II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65438", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate => a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027531", "l": "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380311", "l": "Recruitment of Plk1 to centrosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69738", "l": "phenylsuccinate + succinyl-CoA <=> 2-phenylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23406", "l": "diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate => (2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803890", "l": "SFN dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683593", "l": "ATG7:ATG3:LC3 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654515", "l": "KAL1 binds HS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55072", "l": "2-oxobutanoate + H(+) = CO2 + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17960", "l": "3-oxopropanoate <=> H2O + propynoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19669", "l": "GTP + H2O = GDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696266", "l": "RND2 binds effectors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11964", "l": "5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29407", "l": "2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2 = 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622415", "l": "RIP2 binds NEMO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15497", "l": "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine", "d": []}, {"i": "EC:2.6.1.56", "l": "\"1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45468", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl diphosphate = (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9757256", "l": "MCM3 binds MCM5 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62940", "l": "H2O + N(4)-acetylcytosine = acetate + cytosine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63090", "l": "a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine => a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450422", "l": "KSRP recruits RNA degradation activities (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36344", "l": "2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 => 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39695", "l": "3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH = (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806629", "l": "Formation of tonofilament bundles (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46423", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33975", "l": "DIMBOA beta-D-glucoside + H2O = D-glucose + DIMBOA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433501", "l": "Interaction of other adapter proteins with p-KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18099", "l": "H(+) + xanthine-8-carboxylate => pteridine-2,4,6,7-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983696", "l": "The Immunoglobulin of the BCR binds antigen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954117", "l": "E2F6:TFDP1 binds EPC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43375", "l": "an N-acylsphing-4-enine + dTDP-alpha-D-glucose <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33927", "l": "4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 = 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde", "d": []}, {"i": "EC:1.14.13.163", "l": "\"6-hydroxy-3-succinoylpyridine 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610752", "l": "GLI3R translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31204", "l": "acetyl-CoA + hexanoyl-CoA => 3-oxooctanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42830", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70235", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10465", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O => n acetate + chitosan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43066", "l": "holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate => (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140761", "l": "sequestered tissue factor -> tissue factor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11408", "l": "H(+) + H2O + riboflavin = lumichrome + ribitol", "d": []}, {"i": "EC:3.5.99.1", "l": "\"riboflavinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805640", "l": "AKT phosphorylates KAT6A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68877", "l": "ATP + H(+) + NADPH + piperonylate => AMP + diphosphate + NADP(+) + piperonal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28882", "l": "H(+)(in) + L-tryptophan(in) <=> H(+)(out) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56844", "l": "nocamycin E + S-adenosyl-L-methionine = nocamycin I + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.351", "l": "\"nocamycin O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63731", "l": "candesartan + UDP-alpha-D-glucuronate <=> candesartan-2-N-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34807", "l": "(R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase] = camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35393", "l": "(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5631885", "l": "PRDX1 overoxidizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55572", "l": "4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine = 4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18916", "l": "a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13753", "l": "2 L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + L-glutamine + NADH", "d": []}, {"i": "EC:1.4.1.14", "l": "\"glutamate synthase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678749", "l": "Defective ABCB4 does not transport PC from plasma membrane to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49488", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate = 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": []}, {"i": "EC:4.2.1.168", "l": "\"GDP-4-dehydro-6-deoxy-alpha-D-mannose 3-dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63564", "l": "apelin-13 + H2O = apelin-12 + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-517674", "l": "p-S158,221-HuR binds mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43128", "l": "guanosine(10) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.214", "l": "\"tRNA (guanine(10)-N(2))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877485", "l": "RUNX1 binds to TNFRSF18 (GITR) gene promoter and intron 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18376", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40653", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+) => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1011598", "l": "DOCKs bind to RhoGEFs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12864", "l": "guanosine + H(+) + H2O <=> NH4(+) + xanthosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850534", "l": "PDCL promotes G-protein beta 5 folding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19063", "l": "H(+) + NADPH + nitrate => H2O + NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46823", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19085", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": []}, {"i": "EC:2.6.1.33", "l": "\"dTDP-4-amino-4,6-dideoxy-D-glucose transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031729", "l": "CCR4 chemokine receptor binding", "d": ["Binding to a CCR4 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66704", "l": "H2O + mycophenolyl-CoA = CoA + H(+) + mycophenolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.6", "l": "\"nucleoside deoxyribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169192", "l": "PTP1B dephosphorylates GHR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44569", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) => 2-all-trans-hexaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59806", "l": "D-phenylalanine => L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29587", "l": "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.312", "l": "\"2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37391", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17534", "l": "2-oxoglutarate + an aromatic L-alpha-amino acid => an aromatic oxo-acid + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700171", "l": "Active ALK phosphorylates PLCG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30438", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443439", "l": "c-Src binds Raf1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20661", "l": "D-alanyl-D-alanine + H2O = 2 D-alanine", "d": []}, {"i": "EC:3.4.13.22", "l": "\"D-Ala-D-Ala dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26376", "l": "[thioredoxin]-disulfide + prostamide F2alpha <=> [thioredoxin]-dithiol + prostamide H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156930", "l": "GTP-binding activates eEF2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30179", "l": "oxalate + oxidized 2[4Fe-4S]-[ferredoxin] = 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}, {"i": "EC:1.2.7.10", "l": "\"oxalate oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30636", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29606", "l": "benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] <=> 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66576", "l": "3'-phosphoadenylyl sulfate + 4-isopropylphenol = 4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13860", "l": "a dolichyl beta-D-glucosyl phosphate + H2O <=> a dolichyl phosphate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25613", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = terpentedienyl diphosphate", "d": []}, {"i": "EC:5.5.1.15", "l": "\"terpentedienyl-diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374298", "l": "Opioid receptors bind opioid peptides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209738", "l": "VD3 binds GC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71863", "l": "taurodeoxycholate(out) = taurodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388560", "l": "EDNRA,EDNRB bind EDNs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32008", "l": "9alpha-copalyl diphosphate => diphosphate + isopimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22809", "l": "6-hydroxynicotinate + H2O + O2 => 2,6-dihydroxynicotinate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202702", "l": "CD177 binds PECAM-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35173", "l": "H(+)(in) + novobiocin(out) => H(+)(out) + novobiocin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.116", "l": "\"glucan 1,4-alpha-maltotriohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190829", "l": "Lysosomal degradation of gap junction plaques (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68797", "l": "D-maltose + H2O => alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52192", "l": "(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694527", "l": "Loss of SAR1B GTPase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047071", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0047605", "l": "acetolactate decarboxylase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxy-2-methyl-3-oxobutanoate = (R)-2-acetoin + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34611", "l": "N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose = H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400204", "l": "PPARA binds RXRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15957", "l": "D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O", "d": []}, {"i": "EC:4.2.1.7", "l": "\"altronate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37568", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36384", "l": "carbamoyl adenylate + tobramycin => AMP + H(+) + nebramycin 5'", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37313", "l": "ADP + glycyl-L-glutamine(in) + H(+) + phosphate => ATP + glycyl-L-glutamine(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692755", "l": "CDK1 phosphorylates MAPK6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48624", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2 = (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14521", "l": "(2E)-geraniol + NADP(+) = (2E)-geranial + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.183", "l": "\"geraniol dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618093", "l": "ATP hydrolysis by HSP90 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75786", "l": "ADP(in) <=> ADP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848339", "l": "PNPLA5 hydrolyzes TAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36362", "l": "2 a plastoquinone + 2 H2O + 4 hnu <=> 2 a plastoquinol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.92", "l": "\"3,6-anhydro-alpha-L-galactose dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25833", "l": "1D-chiro-inositol + NAD(+) => H(+) + NADH + scyllo-inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203070", "l": "Association of profilin with monomeric actin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211206", "l": "Translocation of DFF to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51970", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75883", "l": "NAD(+) = ADP-1-deoxy-1,O(4)-didehydro-D-ribose + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362485", "l": "GHBP binds GH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66154", "l": "CoA + H(+) + N-acetylnoradrenaline => acetyl-CoA + noradrenaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10762", "l": "acetate + oxaloacetate => citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23809", "l": "(S)-scoulerine + S-adenosyl-L-methionine => (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31857", "l": "achilleol B => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:1990470", "l": "piRNA cluster binding", "d": ["Binding to piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848339", "l": "PNPLA5 hydrolyzes TAG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20549", "l": "2 Fe(III)-[cytochrome c] + 2 thiosulfate = 2 Fe(II)-[cytochrome c] + 2 H(+) + tetrathionate", "d": []}, {"i": "EC:1.8.2.2", "l": "\"thiosulfate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24299", "l": "(S)-dihydroorotate + H2O <=> H(+) + N-carbamoyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50446", "l": "prostaglandin G3 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47047", "l": "3-dehydrocarnitine + acetyl-CoA <=> acetoacetate + N,N,N-trimethylglycyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29873", "l": "ADP + H(+) + phosphate + thiosulfate(in) => ATP + H2O + thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74460", "l": "1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) => 1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69243", "l": "glucoraphanin + H2O <=> (Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951549", "l": "Carbocymycobactin binds Fe3+ from LTF:2xFe3+:2xCO3(2-) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36583", "l": "dTDP-alpha-D-fucose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985153", "l": "OASL binds DDX58 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41635", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70714", "l": "D-alanine(in) <=> D-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63485", "l": "2-oxoglutarate + L-prolyl-[protein] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43192", "l": "cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13337", "l": "D-glucurono-6,2-lactone + H2O = D-glucuronate + H(+)", "d": []}, {"i": "EC:3.1.1.19", "l": "\"uronolactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54266", "l": "(3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424476", "l": "Activation of RAC1 by VAV2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66210", "l": "(2E,8R)-8-hydroxynonenoyl-CoA + H2O2 => (8R)-8-hydroxynonanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388828", "l": "PD-1 binds B7DC and B7H1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373342", "l": "CX3CR1 binds CX3CL1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31288", "l": "H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA => acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-398185", "l": "LARG binds plexin B1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45411", "l": "(2E)-dodecenoyl-CoA + H(+) + NADH <=> dodecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67710", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55334", "l": "a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => a 3'-hydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691421", "l": "BTK binds BTK inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56268", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71562", "l": "5-N(alpha)-glycyl-dTMP in DNA + A + H2O <=> 5-aminomethyl-dUMP in DNA + AH2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031716", "l": "calcitonin receptor binding", "d": ["Binding to a calcitonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35881", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11749", "l": "fluoroacetaldehyde + L-threonine => 4-fluoro-L-threonine + acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45502", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(84)-[allophycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67733", "l": "uridylyl-uridylyl-ribonucleotide-RNA => a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0002948", "l": "archaeosine synthase activity", "d": ["Catalysis of the reaction: L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785607", "l": "FANCM binds FAAP24 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21309", "l": "(S)-2,3-epoxysqualene => cycloartenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38150", "l": "carbon disulfide + H2O <=> carbonyl sulfide + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55243", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O <=> (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56541", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol => 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5681980", "l": "ATG12 binds ATG7 dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60209", "l": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 => 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-982807", "l": "JAK2 phosphorylation of GHR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35355", "l": "3-hydroxyisopentadecanoyl-CoA = (2E)-13-methyltetradecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38388", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46891", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + O2 <=> 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669023", "l": "TWEAK binds FN14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39861", "l": "a triacyl-sn-glycerol + glycerol => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65380", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71606", "l": "2-oxoglutarate(out) + oxaloacetate(in) <=> 2-oxoglutarate(in) + oxaloacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196017", "l": "Dynamin is recruited to the gap junction plaque (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225961", "l": "Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52170", "l": "8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.87", "l": "\"homoisocitrate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421493", "l": "succinyl-CoA + glycine => delta-aminolevulinate + CoA SH + CO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62151", "l": "dGTP + dTMP <=> dGDP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1169192", "l": "PTP1B dephosphorylates GHR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004932", "l": "mating-type factor pheromone receptor activity", "d": ["Combining with a mating-type factor pheromone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61164", "l": "kaempferol + UDP-beta-L-rhamnose = H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68756", "l": "4 (R)-3-phenyllactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022B + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67834", "l": "CO2 + formaldehyde + L-lysyl(27)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(27)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624953", "l": "ARL13B binds INPP5E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465940", "l": "atRAL is reduced to atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198714", "l": "ERK5 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052934", "l": "alcohol dehydrogenase (cytochrome c) activity", "d": ["Catalysis of the reaction: 2 [Fe(III)cytochrome c] + a primary alcohol = 2 [Fe(II)cytochrome c] + an aldehyde + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9725206", "l": "IgE binds FCERI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296244", "l": "SUCNR1 binds SUCCA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675656", "l": "EDA:EDAR binds EDARADD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54100", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38944", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944246", "l": "Association of procollagen type XXI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49164", "l": "a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0052712", "l": "inositol phosphosphingolipid phospholipase activity", "d": ["Catalysis of the reaction: inositol phosphosphingolipid + H2O = sphingolipid + phosphorylinositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15530", "l": "bis(2-ethylhexyl)phthalate + H2O => 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37886", "l": "acetyl-CoA + oxalate <=> acetate + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015304", "l": "glucose uniporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) = glucose(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5138432", "l": "DVL2 is phosphorylated by PKC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33808", "l": "(E)-ferulate + H(+) => 2-methoxy-4-vinylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18130", "l": "2-oxoaldehyde + H2O + NADP(+) => a 2-oxocarboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093332", "l": "p-EPHB phosphorylates SDC2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879937", "l": "The common beta chain IL3RB binds JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11736", "l": "2-exo-hydroxy-1,8-cineole + NAD(+) = 6-oxocineole + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.241", "l": "\"6-endo-hydroxycineole dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20149", "l": "O2 + quinine + reduced [NADPH--hemoprotein reductase] = 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.55", "l": "\"quinine 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637795", "l": "Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32219", "l": "all-trans-lycopene = gamma-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072541", "l": "peroxynitrite reductase activity", "d": ["Catalysis of the reaction: [protein]-dithiol + ONOO- = [protein]-disulfide + NO2- + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004516", "l": "nicotinate phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47939", "l": "4-hydroxybenzaldehyde + H2O + NADP(+) <=> 4-hydroxybenzoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28598", "l": "H2O + N-acetyl-L-lysine = acetate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44155", "l": "1D-myo-inositol 2-phosphate + H2O <=> myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24027", "l": "(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate <=> (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19362", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate => (2E,6E)-farnesyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937807", "l": "SRC phosphorylates RUNX3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72944", "l": "2 Na(+)(out) + pyruvate(out) => 2 Na(+)(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990715", "l": "mRNA CDS binding", "d": ["Binding to an mRNA molecule coding sequence (CDS)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64365", "l": "prostaglandin G2 => (15S)-15-hydroperoxy-prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33669", "l": "H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) => H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25602", "l": "4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O => 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31503", "l": "beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate = 4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate", "d": []}, {"i": "EC:2.5.1.95", "l": "\"xanthan pyruvate transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48667", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29538", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37528", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31087", "l": "acetyl-CoA + octanoyl-CoA = 3-oxodecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32858", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033439", "l": "ACA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an ACA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39416", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH => (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74943", "l": "2-oxoglutarate + a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + O2 = a (3R)-3-isocyanyl-fatty acid + 2 CO2 + 2 H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49873", "l": "(+)-dehydrodiconiferyl acid ketone + a quinone + H2O => (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53326", "l": "2-glyceryl-prostaglandin E2 => 2-glyceryl-prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67276", "l": "H2O + hexanal + NAD(+) = 2 H(+) + hexanoate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022456", "l": "MECP2 binds 5mC-DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114560", "l": "Adhesion of integrin alphaIIbbeta3 to fibrin network (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694444", "l": "E and N are recruited to the M lattice (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424484", "l": "Phosphorylation of BTK by p-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49617", "l": "2-hydroxy-2-methylpropanal + H2O + NAD(+) => 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25507", "l": "(2E)-geranyl diphosphate <=> beta-phellandrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31070", "l": "6-amino-2-oxohexanoate <=> Delta(1)-piperideine-2-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38257", "l": "(S)-malyl-CoA + succinate => (S)-malate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15200", "l": "a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine <=> an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25453", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + germacrene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36756", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose => beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043805", "l": "indolepyruvate ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: (indol-3-yl)pyruvate + CoA + oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53293", "l": "H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin => H(+) + N-carbamoyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72429", "l": "chloride(out) + K(+)(out) => chloride(in) + K(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12884", "l": "ADP-alpha-D-glucose + sn-glycerol 3-phosphate <=> 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55269", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate => (R)-glycerate + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67370", "l": "acetate + L-glutamine => H2O + N-acetyl-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66855", "l": "(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77094", "l": "Formation of cap binding complex (CBC) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54971", "l": "hexadecanoyl phosphate + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354066", "l": "Translocation of PTK2 to Focal complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034029", "l": "2-oxoglutarate carboxylase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + ATP + bicarbonate = ADP + 2 H+ + oxalosuccinate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52870", "l": "17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 17alpha-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034952", "l": "malonate semialdehyde decarboxylase activity", "d": ["Catalysis of the reaction: malonate semialdehyde + H+ = acetaldehyde + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31031", "l": "2-cis-(+)-abscisate + UDP-alpha-D-glucose = beta-D-glucopyranosyl cis-(+)-abscisate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177930", "l": "GAB1 phosphorylation by EGFR kinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25650", "l": "(2R,5R)-isopulegone + NADP(+) => (6R)-isopiperitenone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38413", "l": "(9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+) => 1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682026", "l": "MRN bound to shortened telomeres activates ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851890", "l": "MET phosphorylates SHC1-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444100", "l": "PROT mediates L-proline uptake (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28705", "l": "Cu(2+)(out) => Cu(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68010", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H(+) + phosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59716", "l": "D-maltopentaono-1,5-lactone + H2O = D-maltopentaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156678", "l": "Activation of Cdc25C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14504", "l": "H2O + L-homocysteine <=> 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199062", "l": "KLRC1:KLRD1 heterodimer interacts with HLA-E (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389756", "l": "AKT interacts and phosphorylates Cot (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5691004", "l": "XPC binds RAD23 and CETN2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37086", "l": "[sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine <=> [sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73979", "l": "(2E,6E)-farnesyl diphosphate = calarene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610726", "l": "The IFT-A complex recruits TULP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38899", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42727", "l": "guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55077", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) => 3-methylsulfanylpropanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706293", "l": "Active FLT3 binds to CBL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39455", "l": "(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36862", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008309", "l": "double-stranded DNA exodeoxyribonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48871", "l": "H2O + NADH <=> AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51231", "l": "17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate <=> 17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66574", "l": "2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+) => 2-naphthol + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59724", "l": "D-maltoheptaono-1,5-lactone + H2O = D-maltoheptaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964465", "l": "DREAM complex binds the PCNA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086078", "l": "gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from a bundle of His cell to a Purkinje myocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32950", "l": "a 2-acylglycerol + an acyl-CoA <=> a 1,2-diacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679044", "l": "FKBP1A binds sirolimus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76031", "l": "2 H2O2 => O2 + 2 H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23381", "l": "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17474", "l": "GTP + H2O => 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.-", "l": "\"Oxygenases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23192", "l": "Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2186771", "l": "RNF111 binds SMAD7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0042800", "l": "histone H3K4 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of up to three methyl groups to the lysine residue at position 4 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59252", "l": "(E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate = (E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71401", "l": "2alpha-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + taxusin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75172", "l": "Formation of RAD50:MRE11 complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102986", "l": "trehalose synthase activity", "d": ["Catalysis of the reaction: an NDP-alpha-D-glucose + D-glucopyranose <=> alpha,alpha-trehalose + H+ + a nucleoside diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36532", "l": "(13Z)-docosenoyl-CoA + H(+) + malonyl-CoA => (15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10846", "l": "L-aspartate + pyridoxal => oxaloacetate + pyridoxamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.38", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36861", "l": "3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA => (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194678", "l": "CYP51A1 demethylates LNSOL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788611", "l": "HYKK phosphorylates 5HLYS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32699", "l": "(2E,6E)-farnesyl diphosphate = beta-sesquiphellandrene + diphosphate", "d": []}, {"i": "EC:4.2.3.123", "l": "\"beta-sesquiphellandrene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13314", "l": "H2O + O2 + sarcosine => formaldehyde + glycine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25664", "l": "alpha-pinene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53512", "l": "(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O = (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37006", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159733", "l": "Furin cleaves pro-factor X to factor X (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21634", "l": "2 1,2-benzoquinone + 2 H2O => 2 catechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22125", "l": "17-O-acetylajmaline + H2O => acetate + ajmaline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012689", "l": "IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400143", "l": "Fatty acid ligands activate PPARA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29869", "l": "ADP + IDP => AMP + ITP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15213", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA", "d": []}, {"i": "EC:2.3.1.61", "l": "\"dihydrolipoyllysine-residue succinyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55640", "l": "C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67573", "l": "3'-phosphoadenylyl sulfate + alpha-muricholate => adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802937", "l": "Inactive BRAF mutants bind mutant RAS:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15402", "l": "a dolichyl phosphate + UDP-alpha-D-glucose => a dolichyl beta-D-glucosyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0046975", "l": "histone H3K36 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group to the lysine residue at position 36 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647980", "l": "mature RAS proteins translocate to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48878", "l": "L-seryl-[protein] + N-acetyl-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0140939", "l": "histone H4 methyltransferase activity", "d": ["Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + a histone H4 = S-adenosyl-L-homocysteine + a methylated histone H4. Histone methylation generally occurs on either an arginine or a lysine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953339", "l": "DNPH1 hydrolyses dGMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49476", "l": "2 H2O + L-1-piperideine-6-carboxylate + NAD(+) = H(+) + L-2-aminoadipate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75752", "l": "(9Z)-octadecenoate + H2O => 10-hydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013110", "l": "RHOC binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050451", "l": "CoA-disulfide reductase (NADP) activity", "d": ["Catalysis of the reaction: 2 CoA + NADP+ = CoA-disulfide + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43632", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421452", "l": "2 protoporphyrinogen IX + 3 O2 => 2 protoporphyrin IX + 6 H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66391", "l": "ATP + H2O + prostaglandin E2(in) <=> ADP + H(+) + phosphate + prostaglandin E2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106411", "l": "XMP 5'-nucleosidase activity", "d": ["Catalysis of the reaction: 5'XMP + H20 = phosphate + xanthosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5600598", "l": "Defective CYP11B2 does not oxidise 11DCORST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44973", "l": "(R)-carnitine + hexanoyl-CoA => CoA + O-hexanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12279", "l": "3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211983", "l": "CYP2J2 oxidises ARA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19574", "l": "[phosphate](n) + ATP => [phosphate](n+1) + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16507", "l": "4-hydroxybenzoate + pyruvate => chorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23666", "l": "a 2-oxocarboxylate + AH2 => A + a (2R)-2-hydroxycarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467659", "l": "AGRN binds NCAM1, PTPRS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694370", "l": "mRNA9a is translated to Nucleoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20300", "l": "an anilide + H2O <=> a carboxylate + aniline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786583", "l": "PUS7 transforms uridine to pseudouridine in tRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42360", "l": "D-allulose = keto-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-917700", "l": "MVB Vesicle Formation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647980", "l": "mature RAS proteins translocate to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42046", "l": "GDP + globoside Globo-H (d18:1(4E)) + H(+) => GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9716947", "l": "ESR1 binds ESR1 agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71009", "l": "L-phenylalanine(in) + L-tryptophan(out) => L-phenylalanine(out) + L-tryptophan(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26035", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37884", "l": "acetyl-CoA + oxalate => acetate + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114306", "l": "SMAC binds XIAP:Caspase-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24279", "l": "acetate + diphosphate <=> acetyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69142", "l": "Recruitment of Dna2 endonuclease (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202703", "l": "CD47 binds SIRP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53143", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59424", "l": "benzylamine + H2O + O2 = benzaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621386", "l": "TRIB1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016404", "l": "15-hydroxyprostaglandin dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15971", "l": "glutathione disulfide + H2O + methylarsonous acid => 2 glutathione + H(+) + methylarsonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8941895", "l": "Formation of CDK4/6:CCND complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58518", "l": "15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48523", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O <=> [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55772", "l": "a jasmonate + an L-alpha-amino acid + ATP = a jasmonyl-L-amino acid + AMP + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.2.52", "l": "\"jasmonoyl--L-amino acid ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77589", "l": "Recognition of AAUAAA sequence by CPSF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411351", "l": "TCF/LEF:CTNNB1 bind the AXIN2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015115", "l": "silicate transmembrane transporter activity", "d": ["Enables the transfer of silicates from one side of a membrane to the other. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates."]}]}
{"type": "biolink:MolecularActivity", "ic": "74.945916858897462", "identifiers": [{"i": "GO:0015280", "l": "ligand-gated sodium channel activity", "d": ["Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."]}, {"i": "REACT:R-HSA-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63463", "l": "(2E,6E,10E)-geranylgeraniol + GTP <=> (2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19811", "l": "CO2 + glyoxylate + 2 NH4(+) => (S)-ureidoglycolate + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33624", "l": "ATP + CoA + dodecanoate => AMP + diphosphate + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25791", "l": "4-hydroxy-2-oxoheptanedioate <=> pyruvate + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51752", "l": "a 2-acylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4-prenylphloroglucinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0031862", "l": "prostanoid receptor binding", "d": ["Binding to a prostanoid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14355", "l": "CO2 + L-xylulose 5-phosphate => 3-dehydro-L-gulonate 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54739", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877281", "l": "PIAS1 binds p-STAT1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420724", "l": "CASR binds Ca2+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507869", "l": "Aquaporins passively transport glycerol into cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64665", "l": "a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41225", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175258", "l": "2-LTR formation due to circularization of viral DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27864", "l": "guanosine + phosphate => 3'-GMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19552", "l": "H2O + o-orsellinate depside <=> H(+) + 2 orsellinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696274", "l": "RND1 binds GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42089", "l": "all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64454", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27818", "l": "L-idonate + NAD(+) = 2-dehydro-L-idonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12427", "l": "(3S)-3-hydroxy-L-aspartate <=> NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5671737", "l": "p-T774-PKN1 binds CDC25C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31474", "l": "beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose <=> beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65667", "l": "citrate(out) + 4 Na(+)(out) <=> citrate(in) + 4 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33226", "l": "2-oxobutanoate + CoA + NAD(+) <=> CO2 + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28672", "l": "2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39781", "l": "(17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15603", "l": "(E)-cinnamate + (R)-3-phenyllactoyl-CoA => (E)-cinnamoyl-CoA + (R)-3-phenyllactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11160", "l": "2-oxoglutarate + L-2,4-diaminobutanoate = L-aspartate 4-semialdehyde + L-glutamate", "d": []}, {"i": "EC:2.6.1.76", "l": "\"diaminobutyrate--2-oxoglutarate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14756", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632668", "l": "SMO translocates to the cilium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426223", "l": "Cation influx mediated by TRPC3/6/7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20810", "l": "CoA + N-acetyl-7-O-acetylneuraminate => acetyl-CoA + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57766", "l": "3-methyl-4-nitrocatechol + NAD(+) + nitrite => 2,6-dinitrotoluene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59325", "l": "D-xylose + O2 => D-xylono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65376", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.375", "l": "\"NNS virus cap methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30785", "l": "(R)-glycerate + 2 H(+) + NADH => D-glyceraldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54919", "l": "9-cis-retinol + NADP(+) <=> 9-cis-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22445", "l": "(E)-coniferol + NADP(+) => (E)-coniferaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31269", "l": "6-oxohexanoate + H(+) + NADPH => 6-hydroxyhexanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69525", "l": "D-sorbitol + O2 => D-glucose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8944457", "l": "MAF1 translocates to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58811", "l": "2',3'-cGAMP + 2 H2O <=> AMP + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32983", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22295", "l": "benzoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> biphenyl-3,5-diol + 4 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46739", "l": "H2O + monoacyl-sn-glycero-3-phosphate <=> a monoacylglycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62224", "l": "H(+) + NADPH + neopatulin = (E)-ascladiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19566", "l": "(2E)-geranyl diphosphate + H2O => diphosphate + sabinene hydrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677051", "l": "Formation of the PCAF-ATAC complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51928", "l": "H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) = (S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH", "d": []}, {"i": "EC:1.5.1.51", "l": "\"N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66125", "l": "2-oxobutanoate + L-histidine => (2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15042", "l": "bis-D-fructose 2',1:2,1'-dianhydride + H2O => inulobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451900", "l": "IL2RB binds JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047494", "l": "serine-phosphoethanolamine synthase activity", "d": ["Catalysis of the reaction: L-serine + CDP-ethanolamine = L-serine-phosphoethanolamine + CMP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45268", "l": "4'-hydroxyechinenone + AH2 + O2 = 4',4'-dihydroxyechinenone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0016759", "l": "cellulose synthase activity", "d": ["Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654625", "l": "Activated FGFR3 binds SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191784", "l": "snRNA Cap hypermethylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23098", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+) => 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61951", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72449", "l": "a dicarboxylate(out) + estrone 3-sulfate(in) => a dicarboxylate(in) + estrone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32470", "l": "2 S-adenosyl-L-methionine + sarcosine <=> glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15445", "l": "H(+) + H2O + O-carbamoyl-L-serine = CO2 + 2 NH4(+) + pyruvate", "d": []}, {"i": "EC:4.3.1.13", "l": "\"carbamoyl-serine ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.19", "l": "\"carboxypeptidase Taq\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37598", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39888", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218822", "l": "CRK binds BCAR1 and or PXN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50986", "l": "prostaglandin E2(in) => prostaglandin E2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72855", "l": "ADP(out) + dADP(in) = ADP(in) + dADP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15623", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP => an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64182", "l": "a fatty acid + L-tryptophan => an N-(fatty acyl)-L-tryptophan + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73411", "l": "succinate(in) + sulfate(out) = succinate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961678", "l": "ORC1 gene expression is stimulated by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63008", "l": "(6Z)-octadecenamide + H2O = (6Z)-octadecenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39034", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41331", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66611", "l": "(tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O <=> GpCpCpA + H(+) + tRNA 3'-end (ribonucleotide 3'-phosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37890", "l": "S-adenosyl-L-methionine + small RNA 3'-end nucleotide <=> H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69624", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.481603666032214", "identifiers": [{"i": "GO:0070851", "l": "growth factor receptor binding", "d": ["Binding to a growth factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13274", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol => 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18455", "l": "[(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate => [(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36668", "l": "(15Z)-tetracosenoyl-CoA + sphinganine => CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69408", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+) = androst-4-ene-3,11,17-trione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050139", "l": "nicotinate-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: nicotinate + UDP-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.61", "l": "\"nardilysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30239", "l": "n a quinone + n H(+) + n hydrogen sulfide = n a quinol + n sulfur", "d": []}, {"i": "EC:1.8.5.4", "l": "\"bacterial sulfide:quinone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015615", "l": "D-allose-importing ATPase activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-allose(out) -> ADP + phosphate + D-allose(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474266", "l": "Formation of collagen fibrils (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130194", "l": "ABL phosphorylates WAVEs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66245", "l": "ATP + H(+) + IC-asc-C9 => diphosphate + IC-asc-C9-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749253", "l": "Formation of MCM2-7 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48884", "l": "NADP(+) + protochlorophyllide a = 3,8-divinyl protochlorophyllide a + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102355", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase activity", "d": ["Catalysis of the reaction: 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O <=> 3-maleylpyruvate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357445", "l": "PAK1-3 dimer disassociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940959", "l": "Neurolysin degrades neurotensin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15187", "l": "CoA + H(+) + N(2)-succinyl-L-arginine => L-arginine + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51499", "l": "a sphingoid base + ATP <=> a sphingoid 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9617595", "l": "SGTA binds mislocalized membrane protein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40840", "l": "FAD + H(+) + nonanoyl-CoA => (2E)-nonenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15578", "l": "H2O + uridine => D-ribose + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44808", "l": "1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) = 2-demethylmenaquinol-10 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202466", "l": "Interaction of Bcl10 to CARMA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786421", "l": "CHIA hydrolyses chitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40592", "l": "decanedioyl-CoA + H2O => CoA + decanedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23950", "l": "H(+) + NADH + succinate semialdehyde => 4-hydroxybutanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58057", "l": "hypotaurine + pyruvate => 2-sulfinoacetaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52010", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75662", "l": "(11Z,14Z)-eicosadienoate + O2 <=> 12-hydroperoxy-(10E,14Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64773", "l": "S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine => 2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75152", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => diphosphate + neoverrucosan-5beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36822", "l": "(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019808", "l": "polyamine binding", "d": ["Binding to a polyamine, an organic compound containing two or more amino groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193996", "l": "11DCORST translocates from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.95", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34593", "l": "Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-7 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734730", "l": "ORC1 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201629", "l": "Caspase-mediated cleavage of Tau (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41413", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32988", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a fatty acid + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29234", "l": "cyanate(in) <=> cyanate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008507", "l": "sodium:iodide symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22147", "l": "cis-aconitate + H2O <=> D-threo-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031757", "l": "Edg-4 lysophosphatidic acid receptor binding", "d": ["Binding to an Edg-4 lysophosphatidic acid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.156", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050146", "l": "nucleoside phosphotransferase activity", "d": ["Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870461", "l": "RABGGTA and RABGGTB bind (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24574", "l": "[(1->4)-alpha-D-glucosyl](n+1) + D-fructose => [(1->4)-alpha-D-glucosyl](n) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53206", "l": "17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69020", "l": "L-aspartate + NADPH + O2 = H2O + N-hydroxy-L-aspartate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982807", "l": "JAK2 phosphorylation of GHR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683888", "l": "LMCD1 binds GATA6, sequestering it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9736953", "l": "FURIN translocates to the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21079", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 <=> CO2 + succinate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11205", "l": "apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin => AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51355", "l": "H2O + N-(9Z-octadecenoyl)-L-serine <=> (9Z)-octadecenoate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678822", "l": "Defective CFTR does not transport Cl- from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24843", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32521", "l": "(E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine => (2E)-geranyl diphosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34939", "l": "H2O + menaquinone-8 + selenite = menaquinol-8 + selenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71710", "l": "H(+)(out) + L-phenylalanyl-L-phenylalanine(out) <=> H(+)(in) + L-phenylalanyl-L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47434", "l": "(2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693061", "l": "STAMBP binds STAM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24258", "l": "ADP + H(+) + kanamycin 3'-phosphate => ATP + kanamycin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71414", "l": "3,3',5-triiodo-L-thyronine(out) + L-tryptophan(in) <=> 3,3',5-triiodo-L-thyronine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.175", "l": "\"D-xylose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16619", "l": "alpha-D-glucose 1-phosphate + D-glucose => beta-D-glucosyl-(1->3)-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693356", "l": "CEMIP hydrolyses HA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63364", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2 = (S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0061860", "l": "DNA clamp unloader activity", "d": ["Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their removal from the DNA duplex, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374692", "l": "Neogenin binds repulsive guidance molecules (RGDs) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0005125", "l": "cytokine activity", "d": ["The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.66", "l": "\"choriolysin L\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18213", "l": "alpha-D-glucose 1-phosphate + CTP + H(+) = CDP-D-glucose + diphosphate", "d": []}, {"i": "EC:2.7.7.33", "l": "\"glucose-1-phosphate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42229", "l": "17beta-estradiol + A => AH2 + estrone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428609", "l": "Type I Na+-coupled phosphate co-transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28283", "l": "(S)-beta-bisabolene => (S)-beta-macrocarpene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64861", "l": "(E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine => (E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73806", "l": "AIR + CO2 => CAIR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706298", "l": "Active FLT3 binds to CSK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130706", "l": "MHC class II antigen processing (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450770", "l": "MWH binds to RHO1:GTP and is activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14377", "l": "(3R)-3-hydroxy-L-aspartate = glycine + glyoxylate", "d": []}, {"i": "EC:4.1.3.14", "l": "\"L-erythro-3-hydroxyaspartate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.88", "l": "\"repressor LexA\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.57", "l": "\"AMP phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141367", "l": "Myristoylation of tBID by NMT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60708", "l": "(1R,3R)-chrysanthemal + H2O + NAD(+) = (1R,3R)-chrysanthemate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130706", "l": "MHC class II antigen processing (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15264", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432590", "l": "Phosphorylated PER is phosphorylated by CK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38829", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11551", "l": "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O <=> 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000319", "l": "BORA binds PLK1 and AURKA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36123", "l": "gibberellin A20 + S-adenosyl-L-methionine = gibberellin A20 methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951727", "l": "cAMP binds PKA tetramer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53486", "l": "17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+) => androst-4-ene-3,11,17-trione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33278", "l": "a 1,2-diacyl-sn-glycerol + H2O <=> a 2-acylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874849", "l": "CREBRF binds CREB3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21272", "l": "ATP + glutathione + spermidine = ADP + glutathionylspermidine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39799", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) = 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46274", "l": "(4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69266", "l": "an isothiocyanate + sulfate => a (Z)-N-(sulfonatooxy)alkanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51729", "l": "dihydroxyacetone phosphate + H2O => dihydroxyacetone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44554", "l": "H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190258", "l": "FGFR2c binds to FGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10768", "l": "(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 = (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51036", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 = 2 H2O + indole-3-pyruvate imine dimer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48232", "l": "acetyl-CoA + L-glutamate 5-semialdehyde = CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde", "d": []}, {"i": "EC:2.3.1.271", "l": "\"L-glutamate-5-semialdehyde N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28602", "l": "L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.39", "l": "\"isoleucine N-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59578", "l": "beta-alanine + N(pros)-methyl-L-histidine => anserine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27799", "l": "(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate => all-trans-octaprenyl diphosphate + 5 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665709", "l": "ERBB2 TMD/JMD heterodimers trans-autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010503", "l": "HOXA2 binds ROBO2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39965", "l": "glycerol + H(+) + hexadecanoate => 2-hexadecanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29531", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}, {"i": "EC:2.4.1.259", "l": "\"dolichyl-P-Man:Man6GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13477", "l": "H2O + L-tryptophan + NADP(+) = H(+) + indole-3-pyruvate + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43706", "l": "diphosphate + tetradecanoyl-AMP => ATP + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354124", "l": "Phosphorylation of pPTK2 by SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62059", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433711", "l": "Cis-homodimerization of nectins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27326", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021609", "l": "ESR-associated SRC autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030504", "l": "inorganic diphosphate transmembrane transporter activity", "d": ["Enables the transfer of inorganic diphosphate across a membrane."]}, {"i": "REACT:R-HSA-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5681987", "l": "LC3 is cleaved by ATG4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183072", "l": "EGFR non-clathrin mediated endocytosis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64608", "l": "L-threonyl-[protein] + UTP = diphosphate + uridylyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649856", "l": "Oxidative damage to the AP site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53524", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36262", "l": "a 1-(1-hydroxyalkyl)-sn-glycerol <=> an aldehyde + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39323", "l": "(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374663", "l": "DCC interaction with Ezrin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29428", "l": "(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) => (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54192", "l": "L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213208", "l": "Type X collagen associates with collagen type II fibrils (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27966", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate", "d": []}, {"i": "EC:4.1.2.50", "l": "\"6-carboxytetrahydropterin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043730", "l": "5-ureido-4-imidazole carboxylate hydrolase activity", "d": ["Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30412", "l": "benzoyl-CoA + benzyl alcohol => benzyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23761", "l": "H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) => reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098616", "l": "selenate adenylyltransferase (ATP) activity", "d": ["Catalysis of the reaction: ATP + H2SeO4 => diphosphate + adenylylselenate."]}, {"i": "REACT:R-HSA-2408525", "l": "H2SeO4 is converted to APSe by PAPSS1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30106", "l": "2,5-didehydro-D-gluconate + H(+) + NADH <=> 5-dehydro-D-gluconate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693111", "l": "RHOF auto-activates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167118", "l": "NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682983", "l": "ATM phosphorylates WHSC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687465", "l": "MRN complex binds RBBP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22888", "l": "(R)-methylmalonyl-CoA = succinyl-CoA", "d": []}, {"i": "EC:5.4.99.2", "l": "\"methylmalonyl-CoA mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432121", "l": "LDL binds to LRP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18691", "l": "a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052633", "l": "isocitrate hydro-lyase (cis-aconitate-forming) activity", "d": ["Catalysis of the reaction: cis-aconitate + H2O = isocitrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50548", "l": "prostaglandin E1 = H2O + prostaglandin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52613", "l": "3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39676", "l": "(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19601", "l": "H(+) + NADH + O2 + orcinol = 2,3,5-trihydroxytoluene + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.6", "l": "\"orcinol 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74665", "l": "acetylcholine(out) => acetylcholine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57039", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose <=> (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl](n) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167408", "l": "The high affinity receptor complex binds to G-protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25803", "l": "H2O + N(1)-acetylspermine + O2 <=> 3-acetamidopropanal + H2O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44654", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047325", "l": "inositol tetrakisphosphate 1-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31272", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 => CO2 + H2O + NAD(+) + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14641", "l": "cyanurate + H2O = biuret + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.5", "l": "\"15-cis-phytoene desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75595", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 11-hydroxy-12,13-epoxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25694", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.81", "l": "\"geranylfarnesyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112342", "l": "Inactivation of MAP2K1 by CDK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18646", "l": "2 putrescine => NH4(+) + sym-homospermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416723", "l": "SEMA6A binds to PLXNA2 and PLXNA4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022911", "l": "CSPG is secreted (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39705", "l": "(13Z)-eicosenoyl-CoA + NADP(+) => (2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74730", "l": "Insulin degradation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43896", "l": "3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53933", "l": "O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433542", "l": "Phosphorylation and activation of VAV1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52649", "l": "H2O + L-arabino-1,4-lactone 5-phosphate => 5-phospho-L-arabinonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784765", "l": "p-Y705-STAT3 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166869", "l": "TRAF6 binds MEKK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694522", "l": "Inner coat assembly and cargo binding (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047766", "l": "carbamoyl-serine ammonia-lyase activity", "d": ["Catalysis of the reaction: O-carbamoyl-L-serine + H2O + H+ = CO2 + 2 NH4 + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73748", "l": "(R)-noradrenaline(in) + 2 H(+)(out) => (R)-noradrenaline(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20880", "l": "10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.66", "l": "\"omega-hydroxydecanoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9690461", "l": "FKBP1A binds tacrolimus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373087", "l": "Receptor CCR6 binds CCL20 ligand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74885", "l": "GUCYs converts GTP to cGMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49410", "l": "[(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate => [(1->2)-beta-D-mannosyl](n) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53053", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate => 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685950", "l": "Endocytosis of protein 3a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.618854952666041", "identifiers": [{"i": "GO:0016407", "l": "acetyltransferase activity", "d": ["Catalysis of the transfer of an acetyl group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35950", "l": "dihydrochanoclavine-I aldehyde + NADP(+) <=> chanoclavine-I aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67736", "l": "N-acetyl-alpha-neuraminate = aceneuramate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0090491", "l": "N-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)", "d": ["Catalyzes the reaction: N-Hydroxy-L-tryptophan + Oxygen + NADPH + H+ = N,N-Dihydroxy-L-tryptophan + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55940", "l": "all-trans-3,4-didehydroretinol + NAD(+) = all-trans-3,4-didehydroretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39238", "l": "(3R)-hydroxytriacontanoyl-CoA <=> (2E)-triacontenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210430", "l": "Release of L-Glutamate at the synapse (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17112", "l": "FMNH2 + N-methylnicotinate + O2 <=> (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57734", "l": "AH2 + all-trans-retinol => A + all-trans-7,8-dihydroretinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64917", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59457", "l": "NADP(+) + tetradecan-1-ol => H(+) + NADPH + tetradecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014294", "l": "RAC2 binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68036", "l": "(S)-cystathionine ketimine + 2 H(+) + NADPH = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58886", "l": "A + chloramphenicol + 2 H2O => AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.363", "l": "\"glucose-6-phosphate dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.110", "l": "\"C5a peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62303", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH <=> 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51605", "l": "2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] => 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38733", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080099", "l": "L-methionine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-methionine + 2-oxoglutarate = 4-methylthio-2-oxobutyrate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660910", "l": "Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11050", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + a 1-organyl-2-acetyl-sn-glycero-3-phospholipid => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-organyl-2-lyso-sn-glycero-3-phospholipid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9032798", "l": "DOCK3 activates RAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52449", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate => 16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75924", "l": "(S)-4-aminopentanoate + H2O + NAD(+) => 4-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12804", "l": "ATP + L-seryl-[tau protein] <=> ADP + H(+) + O-phospho-L-seryl-[tau protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17753", "l": "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine", "d": []}, {"i": "EC:4.4.1.21", "l": "\"S-ribosylhomocysteine lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45962", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62673", "l": "a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine => an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033759", "l": "flavone synthase activity", "d": ["Catalysis of the reaction: a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50699", "l": "calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39558", "l": "3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21175", "l": "L-idonate + NAD(+) <=> 5-dehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29233", "l": "cyanate(out) => cyanate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24451", "l": "enterobactin + UDP-alpha-D-glucose <=> monoglucosyl-enterobactin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18370", "l": "O2 + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74726", "l": "Dissociation of insulin from insulin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668735", "l": "RAC1:GTP binds NOX3 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32343", "l": "(+)-thujan-3-ol + NAD(+) = (+)-thujan-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172666", "l": "RB1 binds condensin II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17464", "l": "D-sedoheptulose 1,7-bisphosphate + H2O <=> D-sedoheptulose 7-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42596", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13631", "l": "(R)-carvone + H(+) + NADPH => (1S,5R)-carveol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849900", "l": "SALMs1-3 bind each other in cis interactions (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62235", "l": "a thymidine(6-4)thymidine in DNA <=> a thymidine dimer in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670414", "l": "KIT mutants bind SFKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5688834", "l": "ATXN3 binds VCP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60828", "l": "a 5'-end triphospho-adenosine in mRNA + H2O = a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66075", "l": "4-methyl-2-oxopentanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863727", "l": "STON2 is neddylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31600", "l": "FMNH2 + NADH + O2 + thymine => (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51680", "l": "(2E,6E)-farnesol + CTP = (2E,6E)-farnesyl phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.153", "l": "\"fructan beta-(2,1)-fructosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67331", "l": "(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione <=> trichosetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61874", "l": "1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate => 1-O-methyl-(9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20299", "l": "a carboxylate + aniline + H(+) => an anilide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0044689", "l": "7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity", "d": ["Catalysis of the reaction: 5-amino-6-(D-ribitylamino)uracil + 4-hydroxyphenylpyruvate + 2 S-adenosyl-L-methionine + H2O = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + 2 5'-deoxyadenosine + 2 L-methionine + oxalate + ammonia + 4 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014433", "l": "RHOG GEFs activate RHOG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72055", "l": "glycodeoxycholate(out) + 2 Na(+)(out) = glycodeoxycholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58170", "l": "(-)-5-epi-eremophilene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662614", "l": "MT1E binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50364", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.73", "l": "\"(S)-nandinine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913725", "l": "viral dsRNA binds IFIH1:TKFC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71609", "l": "(S)-malate(out) + phosphate(in) => (S)-malate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26033", "l": "3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50357", "l": "4-hydroxy-6-methylpretetramide + NADPH + O2 => 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10864", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 = 2-(acetamidomethylene)succinate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48762", "l": "H(+) + L-erythrulose + NADH => L-threitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938930", "l": "RUNX1 binds ELF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755304", "l": "MUL1 ubiquitinates UBXN7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72216", "l": "2 hydrogencarbonate(out) + Na(+)(out) => 2 hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39708", "l": "a long-chain fatty acyl-CoA(out) => a long-chain fatty acyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210430", "l": "Release of L-Glutamate at the synapse (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193537", "l": "5beta-cholestan-3alpha, 7alpha-diol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209302", "l": "Phosphorylated BSK kinase dissociates from CKA scaffolding protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399935", "l": "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32601", "l": "3-isopropenyl-6-oxoheptanoate + H(+) => 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603784", "l": "PEX19:class I PMP binds PEX3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59720", "l": "D-maltohexaono-1,5-lactone + H2O = D-maltohexaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74340", "l": "O-3-methylbutanoyl-(R)-carnitine(in) => O-3-methylbutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65554", "l": "an N-acyl-sphingoid base + lactose => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34283", "l": "2 L-tyrosine + O2 = 2 L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48837", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45783", "l": "(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70799", "l": "L-lysine(in) + L-ornithine(out) = L-lysine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432464", "l": "Phosphorylated TIM:PER heterodimer dissociate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026411", "l": "13(R)-HDPAn-3 translocates from endothelial cell to neutrophil (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018617", "l": "4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity", "d": ["Catalysis of the reaction: 4-aminobenzenesulfonate + 2 H+ + O2 + 2 e- = NH3 + 4-sulfocatechol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605595", "l": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24796", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61875", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 <=> 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41043", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45933", "l": "2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112703", "l": "PTPN11 is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9734730", "l": "ORC1 translocates to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60863", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654422", "l": "Activated FGFR4 binds FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692867", "l": "HRH3 binds pitosilant (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11413", "l": "6-hydroxymethyl-7,8-dihydropterin + ATP => (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703437", "l": "FLT3 fusion dimers autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59285", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O => D-glucose + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75629", "l": "ectocarpin D => (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202203", "l": "Recruitment of PI3K to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50859", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12726", "l": "D-iditol + NAD(+) => H(+) + keto-D-sorbose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53239", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693608", "l": "Initial resection of double-strand break ends (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851988", "l": "BTN2A2 binds T cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27452", "l": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981610", "l": "Neuroglobin binds oxygen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44026", "l": "(2E)-dodecenoyl-CoA + H2O => (3R)-3-hydroxydodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570528", "l": "SUMOylation of XPC with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5660980", "l": "p-S276-RELA binds RELB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58420", "l": "NADP(+) + prenol = 3-methyl-2-butenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16286", "l": "D-octopine + H2O + NAD(+) => H(+) + L-arginine + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23790", "l": "acetyl-[citrate lyase ACP] + AMP + diphosphate => acetate + ATP + holo-[citrate lyase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34410", "l": "3 ATP <=> 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33713", "l": "2 H(+) + maleylacetate + sulfite => 4-sulfomuconolactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31872", "l": "(S)-2,3-epoxysqualene => alpha-seco-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57681", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44799", "l": "2-demethylmenaquinol-13 + S-adenosyl-L-methionine <=> H(+) + menaquinol-13 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63153", "l": "an N-fatty acyl-taurine + H2O => a fatty acid + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35537", "l": "cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2 => cyclo(L-phenylalanyl-L-leucyl) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693575", "l": "DNA-PKcs autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48541", "l": "1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O => dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671702", "l": "AP1G2 binds HGS and CHMP2A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047771", "l": "carboxymethylhydantoinase activity", "d": ["Catalysis of the reaction: L-5-carboxymethylhydantoin + H2O = N-carbamoyl-L-aspartate + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0031705", "l": "bombesin receptor binding", "d": ["Binding to a bombesin receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036400", "l": "short neuropeptide F receptor activity", "d": ["Combining with a short neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Short neuropeptide F is an arthropod peptide of less than 28 residues (as small as 8-10 residues in some species) with a C-terminal RFamide or LRFamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72618", "l": "H(+)(out) + L-alanyl-L-valine(out) <=> H(+)(in) + L-alanyl-L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61217", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53248", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7-oxocholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9793988", "l": "LUBAC ubiquitinates CFLAR at K351, K353 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018785", "l": "RHOBTB2 binds GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54149", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene => 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38384", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40555", "l": "dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 = dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)", "d": []}, {"i": "EC:1.14.13.187", "l": "\"L-evernosamine nitrososynthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21353", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 => (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32242", "l": "gamma-carotene <=> all-trans-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66635", "l": "L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60461", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21799", "l": "dTDP-beta-L-rhamnose + NADP(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853429", "l": "PHLDA1 binds AURKA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002466", "l": "Formation of allysine by LOX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23253", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O => [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64176", "l": "H2O + N-(9Z-octadecenoyl)-L-tryptophan = (9Z)-octadecenoate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2314678", "l": "ASA- acetylates PTGS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034527", "l": "1,2-dihydroxy-8-carboxynaphthalene dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-8-carboxynaphthalene + O2 = 2-carboxy-2-hydroxy-8-carboxychromene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215295", "l": "USP7 deubiquitinates MDM2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32964", "l": "2-oxoglutaramate + H2O => 2-oxoglutarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29951", "l": "H(+)(in) + uridine(in) = H(+)(out) + uridine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0070001", "l": "aspartic-type peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12846", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O => [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357828", "l": "RIPK1 is cleaved by CASP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212380", "l": "Formation of TRAP coactivator complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34464", "l": "8-hydroxycopalyl diphosphate => cis-abienol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381087", "l": "Dimerization of PERK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0030556", "l": "rRNA modification guide activity", "d": ["Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65290", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine => CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73558", "l": "(E,E)-feruperate + O2 + reduced [NADPH--hemoprotein reductase] <=> (E,E)-piperate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63934", "l": "abscisate(out) + ADP + H(+) + phosphate => abscisate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11684", "l": "methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25536", "l": "ent-copalyl diphosphate = diphosphate + ent-sandaracopimara-8(14),15-diene", "d": []}, {"i": "EC:4.2.3.29", "l": "\"ent-sandaracopimaradiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0016869", "l": "intramolecular transferase activity, transferring amino groups", "d": ["Catalysis of the transfer of an amino group from one position to another within a single molecule."]}, {"i": "EC:5.4.3.-", "l": "\"Transferring amino groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676161", "l": "PI(3,5)P2 transports from the late endosome membrane to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850794", "l": "SPINK6 binds KLK5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62604", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50000", "l": "butane + H(+) + NADH + O2 = butan-1-ol + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.230", "l": "\"butane monooxygenase (soluble)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624668", "l": "CEBPA binds CDKN1A (p21) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2203479", "l": "STAB2 (FEEL-2) binds ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25100", "l": "ADP + UTP => ATP + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654409", "l": "Activated FGFR3 binds FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23470", "l": "2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+) => 2-aminobenzenesulfonate + 2 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63712", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60654", "l": "an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline => an N-(acyl)-sphingosylphosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031993", "l": "light transducer activity", "d": ["Absorbing energy from one or more photons and transferring their energy to another molecule, usually a protein, within the cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805122", "l": "AURKB binds TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418172", "l": "F2R binds ARRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41889", "l": "3-oxotetradecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694428", "l": "LMAN family proteins bind glycosylated cargo (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49598", "l": "H(+) + N-acyl-D-galactosylsphing-4-enine + UDP => an N-acylsphing-4-enine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.5", "l": "\"galactose-6-sulfurylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760125", "l": "AcK-NFE2L2-dependent GCLM gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18478", "l": "2,3-dihydroxybenzoate + O2 => 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050554", "l": "abietadiene synthase activity", "d": ["Catalysis of the reaction: (+)-copalyl diphosphate = (-)-abietadiene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45596", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34157", "l": "CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose => acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772430", "l": "CTNNBIP1 binds beta-catenin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68383", "l": "3-hydroxypyruvate + L-asparagine <=> 2-oxosuccinamate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43266", "l": "1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390846", "l": "D2D3,4 bind to DA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008475", "l": "procollagen-lysine 5-dioxygenase activity", "d": ["Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624948", "l": "KIF17 enters the cilium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13357", "l": "3-hydroxypropanoate + NAD(+) = 3-oxopropanoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.59", "l": "\"3-hydroxypropionate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68028", "l": "6,8-dihydroxypurine + H2O + O2 = H2O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68888", "l": "2-methoxybenzoate + ATP + H(+) + NADPH = 2-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14565", "l": "(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653514", "l": "USP17L2 deubiquitinates RCE1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44918", "l": "(3E)-decenoyl-CoA + NADP(+) => (2E,4E)-decadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40384", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21026", "l": "H(+) + NADPH + oxalyl-CoA => CoA + glyoxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249378", "l": "STING recruits TBK1 and STAT6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30429", "l": "(+)-germacrene D + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34602", "l": "15-methylhexadecasphinganine + NADP(+) <=> 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45684", "l": "N-dodecanoyl-sphing-4-enine-1-phosphate(in) = N-dodecanoyl-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018807", "l": "RAC3 GDIs block activation of RAC3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24066", "l": "H(+) + 2 H2O + porphobilinogen => 2 5-aminolevulinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72691", "l": "Formation of the 43S pre-initiation complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37018", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68885", "l": "3-hydroxybenzoate + ATP + H(+) + NADPH => 3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13772", "l": "glycerol + NAD(+) <=> dihydroxyacetone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41905", "l": "3-oxohexadecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.82", "l": "\"ADAMTS-4 endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.395", "l": "\"3alpha-hydroxybile acid CoA 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9650858", "l": "Meglitinides bind ABCC8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005134", "l": "interleukin-2 receptor binding", "d": ["Binding to an interleukin-2 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63397", "l": "A + Fe(II)-heme i + H2O => AH2 + Fe(II)-hydroxyheme i", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65541", "l": "ganglioside GM3 + H2O => an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15025", "l": "S-adenosyl-L-methionine + xanthosine = 7-methylxanthosine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.158", "l": "\"7-methylxanthosine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34203", "l": "2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 = aureusidin 6-O-beta-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30596", "l": "4-hydroxyphenylacetate + FADH2 + O2 => 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031787", "l": "H9 melatonin receptor binding", "d": ["Binding to a H9 melatonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29194", "l": "L-aspartate + menaquinone-8 <=> iminosuccinate + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102391", "l": "decanoate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + decanoate + CoA = AMP + diphosphate + decanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033923", "l": "glucan 1,6-alpha-isomaltosidase activity", "d": ["Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in polysaccharides, to remove successive isomaltose units from the non-reducing ends of the chains."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25620", "l": "terpentedienyl diphosphate <=> diphosphate + terpentetriene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950782", "l": "p-STAT1 binds p-STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351913", "l": "Caspase-mediated cleavage of TJP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60568", "l": "N-acetyl-L-tryptophan = N-acetyl-D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787820", "l": "IL34 dimer binds CSF1R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698016", "l": "PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43096", "l": "guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.209", "l": "\"23S rRNA (guanine(2535)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043841", "l": "(S)-lactate 2-kinase activity", "d": ["Catalysis of the reaction: (S)-lactate + GTP = 2-phospho-(S)-lactate + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028583", "l": "Phosphorylation of YAP by LATS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10125", "l": "H(+) + NADPH + O2 + phenylacetone => benzyl acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18418", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => CMP + ganglioside GM3 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61920", "l": "(2R,4S)-ketoconazole(in) + ATP + H2O = (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21077", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 => CO2 + succinate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38734", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019894", "l": "kinesin binding", "d": ["Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186785", "l": "PDGF-AA clevage by Furin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68951", "l": "esculetin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865454", "l": "CBFB binds RUNX3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805792", "l": "p-S291-PHF20 translocates to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54017", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1470009", "l": "Phosphorylation of STATs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14184", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 <=> (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27788", "l": "CO2 + NADH + succinyl-CoA => 2-oxoglutarate + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0047023", "l": "androsterone dehydrogenase activity", "d": ["Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37407", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903875", "l": "corticosterone binding", "d": ["Binding to corticosterone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65429", "l": "deamido-NAD(+)(in) + NAD(+)(out) => deamido-NAD(+)(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003855", "l": "3-dehydroquinate dehydratase activity", "d": ["Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51192", "l": "(R)-2-hydroxyglutarate + NADP(+) = 2-oxoglutarate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70441", "l": "a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097697", "l": "tRNA 5-carboxymethoxyuridine methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosylmethionine to a 5-carboxymethoxy-modified uridine residue in a tRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050386", "l": "ureidosuccinase activity", "d": ["Catalysis of the reaction: N-carbamoyl-L-aspartate + H2O + 2 H+ = L-aspartate + CO2 + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39983", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43408", "l": "sphinganine + UDP-alpha-D-galactose = beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191299", "l": "Squalene is oxidized to its epoxide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16164", "l": "2 Fe(III)-[leghemoglobin] + NADH <=> 2 Fe(II)-[leghemoglobin] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70036", "l": "6-deoxotyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62634", "l": "an alcohol + glutathione disulfide + H2O => a hydroperoxide + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.94", "l": "\"versiconal hemiacetal acetate esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560789", "l": "Defective SLC26A2 does not cotransport extracellular SO4(2-), H+ to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.240751554780076", "identifiers": [{"i": "GO:0060589", "l": "nucleoside-triphosphatase regulator activity", "d": ["Binds to and modulates the activity of an NTPase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174967", "l": "NAT2 acetylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69173", "l": "Joining of adjacent Okazaki fragments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55261", "l": "2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30662", "l": "4-(phosphooxy)-L-threonine + H2O <=> 4-hydroxy-L-threonine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51692", "l": "prephenate + S-adenosyl-L-methionine = 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.12.-", "l": "\"Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209840", "l": "Two DITs combine to form thyroxine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19342", "l": "2 H(+) + O2 + octane + 2 reduced [rubredoxin] => H2O + octan-1-ol + 2 oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352914", "l": "glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35133", "l": "H(+)(in) + L-alanyl-L-glutamate(in) => H(+)(out) + L-alanyl-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37994", "l": "delta-tocopherol + S-adenosyl-L-methionine <=> beta-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102163", "l": "3-hydroxyacyl-CoA-acyl carrier protein transferase activity", "d": ["Catalysis of the reaction: coenzyme A + a (3R)-3-hydroxyacyl-[acyl-carrier protein] = a (3R)-3-hydroxyacyl-CoA + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53342", "l": "H(+) + NADH + uridine(20) in tRNA => 5,6-dihydrouridine(20) in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65786", "l": "3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42763", "l": "D-glyceraldehyde 3-phosphate + H2O + NAD(+) <=> (2R)-3-phosphoglycerate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40401", "l": "H2O2 + NADP(+) => 1,2-dihydro-beta-NADP + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004732", "l": "pyridoxal oxidase activity", "d": ["Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047358", "l": "UDP-glucose-glycoprotein glucose phosphotransferase activity", "d": ["Catalysis of the reaction: glycoprotein D-mannose + UDP-D-glucose = glycoprotein 6-(D-glucose-1-phospho)-D-mannose + UMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62396", "l": "(1S,2S)-pseudoephedrine + NAD(+) = (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12673", "l": "an aliphatic amide = a nitrile + H2O", "d": []}, {"i": "EC:4.2.1.84", "l": "\"nitrile hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445079", "l": "Phosphorylation of L1 by ERK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71083", "l": "estrone 3-sulfate(out) + 2 Na(+)(out) = estrone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003876", "l": "AMP deaminase activity", "d": ["Catalysis of the reaction: AMP + H2O = IMP + NH3."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050420", "l": "maltose synthase activity", "d": ["Catalysis of the reaction: 2 alpha-D-glucose 1-phosphate = maltose + 2 phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430180", "l": "NCK recruits WASP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48083", "l": "abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase] <=> ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614933", "l": "ACEIs bind ACE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29152", "l": "3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out) => 3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42180", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72971", "l": "5-oxo-L-proline(out) + 2 Na(+)(out) = 5-oxo-L-proline(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13524", "l": "(R)-lactate + 2 Fe(III)-[cytochrome c] <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805061", "l": "CK2 binds FACT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72672", "l": "The 60S subunit joins the translation initiation complex  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52092", "l": "5-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806613", "l": "Keratin tetramers bind to form unit length filaments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39909", "l": "dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805479", "l": "TP53RK phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.74", "l": "\"1,4-dihydroxy-2-naphthoate polyprenyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-741395", "l": "CARD9 binds RIP2 (and NOD2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72697", "l": "Start codon recognition (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169406", "l": "ISGylation of host proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58031", "l": "5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH <=> a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20070", "l": "(Z)-phenylacetaldehyde oxime => H2O + phenylacetonitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62152", "l": "dGMP + dTTP = dGDP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76426", "l": "N-atom dealkylation of caffeine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39158", "l": "(3R)-hydroxyoctadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873918", "l": "Transphosphorylation of JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37371", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O = a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32974", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627056", "l": "Procaspase 9 forms dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38274", "l": "(3S)-citramalyl-CoA <=> 3-methylfumaryl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3321883", "l": "MSL acetylates histone H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45103", "l": "6-demethylmitomycin B + S-adenosyl-L-methionine <=> mitomycin B + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874685", "l": "CBL binds MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508282", "l": "SYK is a substrate for JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390595", "l": "Calcium Binds Troponin-C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12586", "l": "16,17-didehydroprogesterone + H2O => 16alpha-hydroxyprogesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49853", "l": "(3E)-octenoyl-CoA => (2E)-octenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59974", "l": "CoA + O-decanoyl-L-seryl-[protein] => decanoyl-CoA + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64205", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39445", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+) => (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40085", "l": "26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38708", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160935", "l": "SMURF1 ubiquitinates RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61690", "l": "AMP + diphosphate + L-threonyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12124", "l": "4-coumaroyl-CoA + shikimate = CoA + trans-4-coumaroylshikimate", "d": []}, {"i": "EC:2.3.1.133", "l": "\"shikimate O-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106399", "l": "acyl-coenzyme A diphosphatase activity", "d": ["Catalysis of the reaction: an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H+."]}, {"i": "RHEA:50044", "l": "an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40114", "l": "butanoyl-CoA + H2O <=> butanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39513", "l": "(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649108", "l": "HTR3A pentamer binds 5HT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797803", "l": "PTPRD binds SLITRK1-6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190065", "l": "Activated TrkA receptor internalizes to endosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961620", "l": "E2F1 binds the CDC6 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62092", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53044", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58566", "l": "15alpha-stemmadenine intermediate II + 2 H(+) + NADPH => 15alpha-stemmadenine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30326", "l": "all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354173", "l": "Activation of Rap1 by cytosolic GEFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187828", "l": "Translocation of p21 to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210918", "l": "pagA binds ANTXR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31823", "l": "(2E,6E)-farnesyl diphosphate + H2O = cubebol + diphosphate", "d": []}, {"i": "EC:4.2.3.91", "l": "\"cubebol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418091", "l": "F2R binds ARRB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35939", "l": "brevianamide F + dimethylallyl diphosphate = diphosphate + tryprostatin B", "d": []}, {"i": "EC:2.5.1.106", "l": "\"tryprostatin B synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166753", "l": "Conversion of C4 into C4a and C4b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190141", "l": "ALAD binds to Pb2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33187", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114563", "l": "Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165162", "l": "Phosphorylation of TSC2 by PKB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654571", "l": "Activated FGFR1 binds FRS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662466", "l": "XYLB phosphorylates D-xylulose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0016206", "l": "catechol O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705323", "l": "Phosphorylation of TBK1/IKBKE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50285", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46074", "l": "hexadecanoyl-CoA + NAD(+) => (2E)-hexadecenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390912", "l": "HRH1 binds hist (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937814", "l": "RUNX3 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45911", "l": "chloroorienticin B + dTDP-beta-L-vancosamine <=> chloroeremomycin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640195", "l": "RRAGA,B hydrolyzes GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052586", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, with a quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a quinone or similar compound."]}, {"i": "EC:1.7.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73716", "l": "ATP(in) + dATP(out) => ATP(out) + dATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264622", "l": "Cho is acetylated to AcCho by CHAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28711", "l": "H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) = H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6794346", "l": "NRXNs bind NLGNs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8934465", "l": "SHC1 binds PTPN12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211219", "l": "Translocation of caspase-3 to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49610", "l": "2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH => 2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34966", "l": "Na(+)(in) <=> Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35298", "l": "adenylyl-molybdopterin + H(+) + tungstate <=> AMP + H2O + W-molybdopterin cofactor", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44820", "l": "1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-13 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44980", "l": "(R)-carnitine + butanoyl-CoA = CoA + O-butanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21313", "l": "2,5-dihydroxybenzoate + H(+) => CO2 + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019159", "l": "nicotinamide-nucleotide amidase activity", "d": ["Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697838", "l": "ATP7A transfers Cu from ATOX1 to SOD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769397", "l": "SOST binds LRP5/6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73638", "l": "CTP(out) + dGMP(in) <=> CTP(in) + dGMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55748", "l": "coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.8.98.5", "l": "\"H2:CoB-CoM heterodisulfide,ferredoxin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41556", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2 = (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.47", "l": "\"[50S ribosomal protein L16]-arginine 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176445", "l": "SMURF2 binds SMAD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102970", "l": "7-deoxyloganetic acid glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 7-deoxyloganetate <=> H+ + 7-deoxyloganate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30610", "l": "A + all-trans-phytofluene <=> AH2 + all-trans-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23422", "l": "alpha,alpha-trehalose + phosphate => alpha,alpha-trehalose 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25598", "l": "5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4085083", "l": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31171", "l": "(3S)-hydroxytetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70239", "l": "a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.40", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51825", "l": "ATP(in) + CoA(in) + H(+)(out) + octanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700171", "l": "Active ALK phosphorylates PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13577", "l": "a wax ester + H2O = a long chain fatty alcohol + a long-chain fatty acid + H(+)", "d": []}, {"i": "EC:3.1.1.50", "l": "\"wax-ester hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13087", "l": "CoA + L-2-acetamido-6-oxoheptanedioate => (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014293", "l": "RAC2 GDIs block activation of RAC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0005471", "l": "ATP:ADP antiporter activity", "d": ["Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54570", "l": "a pseudouridine in rRNA => a uridine in rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686013", "l": "Nsp3:nsp4 binds to nsp6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3200023", "l": "Phosphorylated ETS1 binds p16INK4A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35001", "l": "ADP(out) + ATP(in) => ADP(in) + ATP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352059", "l": "SLC6A15-mediated amino acid uptake (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69878", "l": "6-deoxocastasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxycastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73954", "l": "(2E,6E)-farnesyl diphosphate <=> beta-maaliene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67428", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612073", "l": "NGF- and MAPK-dependent EGR1, EGR2 and EGR4 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799409", "l": "HIPK2 phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.83", "l": "\"4-hydroxyphenylacetate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008822", "l": "PPM1D dephosphorylates RUNX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70292", "l": "3-(2-aminophenyl)-3-oxopropanal => H2O + quinolin-4-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75902", "l": "1,2-diacyl-sn-glycero-3-phospho-N-acyl-L-serine + H2O <=> 1-acyl-sn-glycero-3-phospho-N-acyl-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139941", "l": "Binding of IP3 to IP3 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694780", "l": "Spike translocates to ERGIC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32128", "l": "2-oxoglutarate + L-proline + O2 => cis-4-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74807", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627089", "l": "CASP9 is phosphorylated at T412 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75903", "l": "ADP-D-glycero-beta-D-manno-heptose + L-seryl-[protein] = ADP + H(+) + O-(D-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879562", "l": "SLCO2B1 has a narrow substrate specificity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53431", "l": "a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] <=> a thymidine in DNA + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009488", "l": "IL34 binds CSF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62797", "l": "H(+) + NADPH + O2 + 2 rubrofusarin B => aurasperone A + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9760402", "l": "ILF3 binds HOXC8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37400", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12157", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) => 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24352", "l": "ethyl (R)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.279", "l": "\"(R)-3-hydroxyacid-ester dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682020", "l": "MRN complex binds shortened telomeres (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69456", "l": "3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380620", "l": "Reuptake of serotonin from the synapse (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15332", "l": "(S)-ureidoglycolate + NAD(+) <=> H(+) + N-carbamoyl-2-oxoglycine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29238", "l": "a menaquinone + H(+) + NADH <=> a menaquinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606163", "l": "p-SYK and LYN phosphorylate BTK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43549", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60709", "l": "(1R,3R)-chrysanthemal + H2O + NAD(+) => (1R,3R)-chrysanthemate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036199", "l": "cholest-4-en-3-one 26-monooxygenase activity", "d": ["Catalysis of the reaction: cholest-4-en-3-one + NADH + H+ + O2 = 26-hydroxycholest-4-en-3-one + NAD+ + H2O. This reaction involves the hydroxylation of the C26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59878", "l": "(indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+) => (indol-3-yl)butanoate + ATP + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168412", "l": "MDP elicits a NOD2 response (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73751", "l": "(R)-adrenaline(in) + 2 H(+)(out) = (R)-adrenaline(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0034979", "l": "NAD-dependent protein deacetylase activity", "d": ["Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26329", "l": "(8S)-8-amino-7-oxononanoate + L-lysine = (7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate", "d": []}, {"i": "EC:2.6.1.105", "l": "\"lysine--8-amino-7-oxononanoate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50883", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol <=> 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44227", "l": "16-hydroxyhexadecanoate + ATP + CoA <=> 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14257", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.152", "l": "\"4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23998", "l": "a ribonucleoside 5'-phosphate + diphosphate + H(+) => a ribonucleoside 5'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46952", "l": "2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.17.1.11", "l": "\"formate dehydrogenase (NAD(+), ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28768", "l": "ethylnitronate + O2 => acetaldehyde + chemical entity + H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667456", "l": "AVPR1A,B bind desmopressin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52286", "l": "11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032931", "l": "histone H3K56 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689861", "l": "Recruitment of XPA and release of CAK  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445699", "l": "ATP Hydrolysis By Myosin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51644", "l": "cholesterol + H(+) + NADH + O2 = 7-dehydrocholesterol + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56607", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13331", "l": "a 3-oxo-Delta(1)-steroid + AH2 => A + a 3-oxosteroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430347", "l": "MigFilin associates with Filamin and F-actin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372422", "l": "oxaloacetate + NADH + H+ <=> malate + NAD+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941312", "l": "TUT4,TUT7 oligouridylate mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878013", "l": "RUNX2 and SMAD1 complex binds the SMAD6 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433395", "l": "Dimerization of sSCF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215406", "l": "PRMT5 binds WDR77 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662781", "l": "CD163 gene produces CD163 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24395", "l": "dTDP-L-dihydrostreptose + streptidine 6-phosphate <=> dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65233", "l": "3-hydroxydodecanoyl-CoA + H2O => 3-hydroxydodecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73251", "l": "cirsimaritin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102854", "l": "1-18:2-2-18:1-phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:1-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51798", "l": "colupulone + diphosphate + H(+) => deoxycohumulone + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.13.2.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417825", "l": "P2Y11 receptor can bind to ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709179", "l": "DPP4 binds DPP4 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007901", "l": "IL1F10 binds IL1RL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75131", "l": "neomorphinone = morphinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23300", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate = (2Z,6E)-farnesyl diphosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.68", "l": "\"(2Z,6E)-farnesyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43957", "l": "15-methylhexadecanoate + H(+) + NADPH + O2 => H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18043", "l": "8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50147", "l": "ethyl (9Z)-hexadecenoate + H2O <=> (9Z)-hexadecenoate + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102118", "l": "gibberellin A4 carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: gibberellin A4 + S-adenosyl-L-methionine <=> gibberellin A4 methyl ester + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68766", "l": "8 AMP + 8 diphosphate + 8 H(+) + PF1022D + 4 S-adenosyl-L-homocysteine => (R)-3-phenyllactate + 3 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14256", "l": "guanosine 3',5'-bis(diphosphate) + H2O <=> diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622363", "l": "CEBPA binds the promoter of the KLF5 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340124", "l": "CSN polymer binds CaPO4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75251", "l": "carminate + O2 = 3'-dehydrocarminate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12475", "l": "H2O + N-ethylglycine + O2 <=> ethylamine + glyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805126", "l": "AURKB phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41902", "l": "3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + malonyl-[ACP] + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73540", "l": "dCTP(out) + UTP(in) => dCTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229343", "l": "AXIN is phosphorylated in the destruction complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749197", "l": "ORC1 binds to H4K20me2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636684", "l": "ndkA dephosphorylates RAB5A:GTP,RAB7A:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448678", "l": "CTSG cleaves CASP1(1-404) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71869", "l": "glycodeoxycholate(in) => glycodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32902", "l": "1,8-cineole + O2 + reduced [flavodoxin] <=> 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62371", "l": "Fe(2+)(out) + 2 hydrogencarbonate(out) <=> Fe(2+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18758", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 => CO2 + cylindrospermopsin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41269", "l": "(15Z)-tetracosenoate + sphing-4-enine => H2O + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981093", "l": "IL12 bound to IL12R internalises (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729279", "l": "Nucleoprotein is ADP-ribosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.63", "l": "\"methylated-DNA--[protein]-cysteine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5220990", "l": "TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33816", "l": "CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66428", "l": "D-arabinose(out) + H(+)(out) = D-arabinose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36690", "l": "hexadecanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782336", "l": "ADAT1 deaminates adenosine-37 in tRNA(Ala) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10224", "l": "ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4647613", "l": "Transcriptional activation of CDKN1A by TP53 is inhibited by EP400 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.2.4", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062146", "l": "4-chloro-allylglycine synthase activity", "d": ["Catalysis of the reaction: 4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)."]}, {"i": "RHEA:59888", "l": "4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17162", "l": "2,6-dioxo-6-phenylhexa-3-enoate + H2O => 2-oxopent-4-enoate + benzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46604", "l": "[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr protein]-L-serine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45660", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45801", "l": "15-demethylaclacinomycin T + AH2 + O2 => 10-decarboxymethylaclacinomycin T + A + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010539", "l": "SLIT2 gene expression is stimulated by ISL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5444516", "l": "Formation of MSH2:MSH6 Complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70692", "l": "ornithine => putrescine + CO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57550", "l": "[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390184", "l": "YKI binds to SD and activates transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018826", "l": "RHOT2 hydrolyzes GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762345", "l": "PREDN:ALB dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56753", "l": "a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25763", "l": "(2R,3S)-3-methylmalate + NAD(+) = 3-carboxy-2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36764", "l": "alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5213466", "l": "RIPK3 is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74461", "l": "1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in) => 1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33289", "l": "1-pyrroline + AH2 + propane-1,3-diamine => A + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051720", "l": "DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpNpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpNpG."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66590", "l": "a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in 26S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72392", "l": "2 hydrogencarbonate(out) + oxalate(in) => 2 hydrogencarbonate(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003883", "l": "CTP synthase activity", "d": ["Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018849", "l": "muconate cycloisomerase activity", "d": ["Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647994", "l": "RAS proteins are depalmitoylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54152", "l": "a uridine in rRNA + S-adenosyl-L-methionine = a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32172", "l": "H(+) + NADPH + O2 + phenylacetyl-CoA => 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29936", "l": "cytosine(in) + H(+)(in) => cytosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538822", "l": "Cytosolic PP2A dephosphorylates phosphorylated PER complexed with TIM and DCO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70808", "l": "4-deoxy-4-sulfo-D-erythrose => 4-deoxy-4-sulfo-D-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114671", "l": "vWF binds to collagen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58980", "l": "citral + H2O + O2 = 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692749", "l": "CDC14A,B bind MAPK6 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168888", "l": "Alpha1-Microglobulin binds heme (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37654", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9028730", "l": "Activated NTRK2 binds FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388833", "l": "Phosphorylation of CTLA-4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10455", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52588", "l": "choloyl-CoA + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019147", "l": "(R)-aminopropanol dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-1-aminopropan-2-ol + NAD+ = aminoacetone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202692", "l": "PIP3 binds to RhoA and activates it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8934819", "l": "Cytoplasmic proteases cleave Profilaggrin producing Filaggrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13377", "l": "alpha-D-glucose 1-phosphate + ATP = ADP + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.10", "l": "\"phosphoglucokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72268", "l": "chloride(out) + formate(in) => chloride(in) + formate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15179", "l": "a fatty acid + H(+) + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37694", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA <=> 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706287", "l": "Active FLT3 binds to ABL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167089", "l": "Recognition and binding of the HIV-1 mRNA cap by the cap-binding complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66325", "l": "iodide(out) => iodide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62629", "l": "a hydroperoxide + H(+) + NADH => an alcohol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51341", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27697", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate <=> (S)-3-methyl-2-oxopentanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41178", "l": "Co(I)-[dimethylamine-specific corrinoid protein] + dimethylamine + H(+) <=> methyl-Co(III)-[dimethylamine-specific corrinoid protein] + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39756", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69897", "l": "cytidine(in) + Na(+)(in) => cytidine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010646", "l": "AKAP5 recruits PKC to ROBO3.1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54861", "l": "(2E)-geranial + H(+) + NADPH + O2 => (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64027", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine) <=> H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867041", "l": "EGFR phosphorylates EPS15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61816", "l": "16,17-didehydropregnenolone + UDP-alpha-D-glucose = 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003925", "l": "G protein activity", "d": ["A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374665", "l": "DCC interaction with SIAH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5334827", "l": "SUMO-CRABP2 binds atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42362", "l": "keto-D-fructose => D-allulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157926", "l": "NICD1 traffics to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44869", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol => 1,2-diacyl-sn-glycero-3-phosphoethanol + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009309", "l": "RUNX2 binds STUB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64820", "l": "2-phenylacetamide + H2O = 2-phenylacetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73761", "l": "2'-O-methylguanosine(2553) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2553) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980044", "l": "NOTCH1 binds JAG2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51243", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661217", "l": "MT1A binds zinc (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944454", "l": "mTORC1 phosphorylates MAF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450259", "l": "Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40806", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) <=> 3,6-anhydro-L-galactonate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.096227290700369", "identifiers": [{"i": "GO:0015078", "l": "proton transmembrane transporter activity", "d": ["Enables the transfer of a proton from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14814", "l": "L-2-aminohexano-6-lactam => D-2-aminohexano-6-lactam", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55476", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211983", "l": "CYP2J2 oxidises ARA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.22", "l": "\"aminopeptidase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982637", "l": "Opsins binds G alpha-t (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624954", "l": "INPP5E translocates to the primary cilium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.37", "l": "\"FAD reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44009", "l": "a 2-methyl-branched fatty aldehyde + H2O + NAD(+) => a 2-methyl fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55992", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55644", "l": "ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] = ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.179166783752436", "identifiers": [{"i": "GO:0015453", "l": "oxidoreduction-driven active transmembrane transporter activity", "d": ["Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source."]}, {"i": "TCDB:3.D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50898", "l": "(8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate => 8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809561", "l": "I(1,3)P2 is dephosphorylated into I1P by MTMR7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18850", "l": "a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase] => a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44222", "l": "15-hydroxypentadecanoyl-CoA + AMP + diphosphate => 15-hydroxypentadecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11800", "l": "H2O + NAD(+) = AMP + beta-nicotinamide D-ribonucleotide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218805", "l": "PKC autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174446", "l": "Removal of remaining Flap from the C-strand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140292", "l": "ADP-ribosylserine hydrolase activity", "d": ["Catalysis of the reaction: (ADP-D-ribosyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + ADP-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74671", "l": "UDP-beta-L-arabinopyranose(in) + UMP(out) = UDP-beta-L-arabinopyranose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30683", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-D-mannosamine + UDP", "d": []}, {"i": "EC:3.2.1.183", "l": "\"UDP-N-acetylglucosamine 2-epimerase (hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30467", "l": "(2Z,6Z)-farnesyl diphosphate = (+)-endo-beta-bergamotene + diphosphate", "d": []}, {"i": "EC:4.2.3.53", "l": "\"(+)-endo-beta-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64054", "l": "CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine => (13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17770", "l": "choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71894", "l": "dGMP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-dGMP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39815", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate = (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75068", "l": "chloride(out) + 2 hydrogencarbonate(in) + Rb(+)(in) => chloride(in) + 2 hydrogencarbonate(out) + Rb(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53160", "l": "H2O + N-acyl-sn-glycero-3-phosphoethanolamine = an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176452", "l": "Degradation of ubiquitinated SMAD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.45", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28127", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose => alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20080", "l": "guanosine(18) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18901", "l": "H(+) + H2O + N-benzyloxycarbonyl-L-leucine = benzyl alcohol + CO2 + L-leucine", "d": []}, {"i": "EC:3.5.1.64", "l": "\"N(alpha)-benzyloxycarbonylleucine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59130", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate => (S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10152", "l": "ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate + H(+) + H2O", "d": []}, {"i": "EC:2.7.2.2", "l": "\"carbamate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5625416", "l": "Anterograde IFT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32946", "l": "a 1,2-diacyl-sn-glycerol + CDP-ethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004134", "l": "4-alpha-glucanotransferase activity", "d": ["Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12837", "l": "ATP + choline = ADP + H(+) + phosphocholine", "d": []}, {"i": "EC:2.7.1.32", "l": "\"choline kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052903", "l": "N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity", "d": ["Catalysis of the reaction: H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15146", "l": "D-maltose => alpha,alpha-trehalose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15037", "l": "putrescine + S-adenosyl-L-methionine = H(+) + N-methylputrescine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.53", "l": "\"putrescine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56633", "l": "H2O + neryl diphosphate => 1,8-cineole + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54822", "l": "a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605717", "l": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42712", "l": "S-adenosyl-L-methionine + uridine(54) in tRNA = 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.35", "l": "\"tRNA (uracil(54)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17780", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33082", "l": "6-amino-6-deoxyfutalosine + H2O <=> adenine + dehypoxanthine futalosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58099", "l": "1-tetracosanoylglycerol + H2O <=> glycerol + H(+) + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61302", "l": "acetaldehyde + dihydroxyacetone phosphate => 5-deoxy-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.25", "l": "\"thiomorpholine-carboxylate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62290", "l": "(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate => (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928620", "l": "PAK1 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "59.776797861935322", "identifiers": [{"i": "GO:0016798", "l": "hydrolase activity, acting on glycosyl bonds", "d": ["Catalysis of the hydrolysis of any glycosyl bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112385", "l": "Addition of nucleotides leads to transcript elongation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69333", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] + NAD(+) => 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396009", "l": "STING binds c-di-GMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11932", "l": "2-hydroxy-2-methylpropanenitrile = acetone + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35025", "l": "hydroquinone O-beta-D-glucopyranoside(in) => hydroquinone O-beta-D-glucopyranoside(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018706", "l": "pyrogallol hydroxytransferase activity", "d": ["Catalysis of the reaction: 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16273", "l": "an N-acylsphing-4-enine + CDP-choline = a sphingomyelin + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.3", "l": "\"ceramide cholinephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1028820", "l": "Formation of VAF (virus-activated factor) complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46557", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + lathosterol + O2 => 7-dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49781", "l": "docosanoyl-CoA + glycine => CoA + H(+) + N-docosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65470", "l": "CoA + propyl acetate => 1-propanol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043758", "l": "acetate-CoA ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: ATP + acetate + CoA = ADP + phosphate + acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31766", "l": "a 2-oxocarboxylate + L-methionine <=> 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9725855", "l": "NR3C2 binds NR3C2 antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23042", "l": "(R)-2-ethylmalate + CoA + H(+) => 2-oxobutanoate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60736", "l": "(2E,6E)-farnesal + H2O + NADP(+) = (2E,6E)-farnesoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53504", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate", "d": []}, {"i": "EC:4.1.99.23", "l": "\"5-hydroxybenzimidazole synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-606349", "l": "Mis18 complex binds the centromere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47289", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665698", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23090", "l": "1-O-alkylglycerone 3-phosphate + ADP + H(+) => ATP + O-alkylglycerone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047034", "l": "15-hydroxyicosatetraenoate dehydrogenase activity", "d": ["Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210881", "l": "Dimerization of Tie2/Ang1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45981", "l": "3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42875", "l": "N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19785", "l": "2-oxoglutarate + dihydroclavaminate + O2 = clavaminate + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5138432", "l": "DVL2 is phosphorylated by PKC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36110", "l": "gibberellin A4 + S-adenosyl-L-methionine <=> O-methyl gibberellin A4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070538", "l": "oleic acid binding", "d": ["Binding to oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140890", "l": "H1 histone chaperone activity", "d": ["A histone chaperone that carries a H1 histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27754", "l": "H2O + methylglyoxal = (R)-lactate + H(+)", "d": []}, {"i": "EC:4.2.1.130", "l": "\"D-lactate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697423", "l": "Endocytosis of SARS-CoV-2 Virion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604731", "l": "Autocatalytic activation of MMP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52359", "l": "3'-phosphoadenylyl sulfate + pregnenolone <=> adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050569", "l": "glycolaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: glycolaldehyde + H2O + NAD(+) = glycolate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48981", "l": "3,4-dichlorocatechol + O2 => (2Z,4Z)-2,3-dichloromuconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.233323709485049", "identifiers": [{"i": "GO:0019199", "l": "transmembrane receptor protein kinase activity", "d": ["Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625426", "l": "Retrograde IFT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25871", "l": "H2O + N(1),N(12)-diacetylspermine + O2 <=> 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37611", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358791", "l": "Phosphorylation of USP8 by P-AKT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40336", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045517", "l": "interleukin-20 receptor binding", "d": ["Binding to an interleukin-20 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050332", "l": "thiamine pyridinylase activity", "d": ["Catalysis of the reaction: pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51755", "l": "a 2-acylphloroglucinol + dimethylallyl diphosphate <=> a 2-acyl-4-prenylphloroglucinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30913", "l": "a carboxylate + sphing-4-enine-phosphocholine => a sphingomyelin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202713", "l": "CD84 homodimerises (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865182", "l": "OTUD7A hydrolyses K11diUb (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31461", "l": "2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209815", "l": "Tyrosine is monoiodinated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47940", "l": "ganglioside GM2 (d18:1(4E)) + H2O = ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43519", "l": "2-carboxy-5-formylfuran + H2O <=> 2-carboxy-5-(dihydroxymethyl)furan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45272", "l": "12-phosphooxy-(9Z)-octadecenoate + H2O = 12-hydroxy-(9Z)-octadecenoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362416", "l": "Frataxin binds iron (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47399", "l": "H2O + octadecanoate ester <=> an aliphatic alcohol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49604", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) = 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43858", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72330", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + vanillate <=> 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033772", "l": "flavonoid 3',5'-hydroxylase activity", "d": ["Catalysis of the reactions: a flavanone + NADPH + H+ + O2 = a 3'-hydroxyflavanone + NADP+ + H2O, and a 3'-hydroxyflavanone + NADPH + H+ + O2 = a 3',5'-dihydroxyflavanone + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31199", "l": "(3S)-hydroxyoctanoyl-CoA = (2E)-octenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446372", "l": "Association of  PARVA with TESK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55147", "l": "[(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+) <=> [4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18961", "l": "D-allose + L-lysyl-[protein] = H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44608", "l": "3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70667", "l": "a fatty acyl-[ACP] + L-lysyl-[protein] = H(+) + holo-[ACP] + N(6)-(fatty acyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19181", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.9", "l": "\"very-long-chain acyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74248", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17508", "l": "H2O + N-(long-chain fatty acyl)ethanolamine <=> a long-chain fatty acid + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047216", "l": "inositol 3-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: myo-inositol + UDP-galactose = O-alpha-D-galactosyl-(1,3)-1D-myo-inositol + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43004", "l": "H(+) + O-carbamoyl-L-serine = 2-aminoprop-2-enoate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102380", "l": "steviolbioside glucosyltransferase activity (rebaudioside B forming)", "d": ["Catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = rebaudioside B + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12843", "l": "L-alanine + pyridoxal => pyridoxamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24499", "l": "4-O-deacetylvindoline + acetyl-CoA <=> CoA + vindoline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445448", "l": "HHIP binds Hedgehog (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392834", "l": "Activation of EPACs by cAMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37667", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.313", "l": "\"protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55897", "l": "chloride + FADH2 + L-tryptophan + O2 => 5-chloro-L-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.-", "l": "\"Metalloendopeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399711", "l": "Activation of Ca impermeable AMPA receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5591086", "l": "SERPINA5 binds activated protein C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67877", "l": "3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine => 3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36733", "l": "1-nitrocyclohexene + H(+) + NADPH => 1-nitrocyclohexan + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730862", "l": "Autophosphorylation of LYN kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944352", "l": "TCF/LEF binds WNT promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41544", "l": "8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.306", "l": "\"8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)-tetracenomycin-C 3'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17861", "l": "21-hydroxyprogesterone = 20-hydroxy-3-oxopregn-4-en-21-al", "d": []}, {"i": "EC:5.3.1.21", "l": "\"corticosteroid side-chain-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30126", "l": "H2O + tetradecanoyl-[ACP] <=> H(+) + holo-[ACP] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75641", "l": "(12S,13R)-epoxy-(10R)-hydroxy-(8E)-octadecenoate => (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23164", "l": "a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose = a flavonol 7-O-beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.237", "l": "\"flavonol 7-O-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676596", "l": "TRAF3 binds BAFFR:BAFF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38720", "l": "(R)-carnitine(out) + ATP + H2O => (R)-carnitine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018804", "l": "RAC3 GEFs activate RAC3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18975", "l": "4-O-deacetylvindoline + CO2 + succinate => 2-oxoglutarate + deacetoxyvindoline + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002950", "l": "ceramide phosphoethanolamine synthase activity", "d": ["Catalysis of the reaction: CDP-ethanolamine + a ceramide = CMP + a ceramide phosphoethanolamine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051432", "l": "BH1 domain binding", "d": ["Binding to a BH1 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646685", "l": "Aggresome dissociates from dynein and microtubule (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012835", "l": "GDIs block activation of RHOA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77081", "l": "Formation of the CE:GMP intermediate complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65210", "l": "(S)-3-hydroxybutanoate + CoA + H(+) => (3S)-3-hydroxybutanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34340", "l": "(22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0070186", "l": "growth hormone activity", "d": ["The action characteristic of growth hormone, a peptide hormone that is secreted by the anterior pituitary or the placenta into the circulation, and binds to membrane receptors in target tissues to stimulate body growth."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44901", "l": "D-galactono-1,4-lactone + H2O => D-galactonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67456", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649686", "l": "NEIL2 recognizes and binds 5-OHU-dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981355", "l": "RASA1 binds RAS:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46758", "l": "a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32821", "l": "chromate(out) => chromate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61226", "l": "2-oxosuccinamate + H2O2 + NH4(+) => H2O + L-asparagine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-555065", "l": "Formation of clathrin coated vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033961", "l": "cis-stilbene-oxide hydrolase activity", "d": ["Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651828", "l": "PARG dePARylates PARP1,PARP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5444516", "l": "Formation of MSH2:MSH6 Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176517", "l": "SULTs transfer (SO4)2- group to PREG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097726", "l": "LEM domain binding", "d": ["Binding to a LEM domain. The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) is present in a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44875", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114684", "l": "Phosphorylation of Syntaxin-4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14233", "l": "a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA", "d": []}, {"i": "EC:2.3.1.52", "l": "\"2-acylglycerol-3-phosphate O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59459", "l": "NADP(+) + tetradecan-1-ol <=> H(+) + NADPH + tetradecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445699", "l": "ATP Hydrolysis By Myosin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140830", "l": "L-glutamine, sodium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-glutamine(out) + Na+(out) = H+(out) + L-glutamine(in) + Na+(in)."]}, {"i": "RHEA:71127", "l": "H(+)(in) + L-glutamine(out) + Na(+)(out) = H(+)(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814695", "l": "PERP binds desmosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218821", "l": "PDK1 phosphorylates PKC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781814", "l": "USP19 deubiquitinates RNF123 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0046997", "l": "oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin."]}, {"i": "EC:1.5.8.-", "l": "\"With a flavin as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29046", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH <=> (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59274", "l": "D-cysteine => L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972967", "l": "POU5F1 (OCT4), SOX2, NANOG bind the EPHA1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70481", "l": "2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37908", "l": "(9Z)-octadecenoate + O2 => (8E,10S)-10-hydroperoxy-octadeca-8-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50761", "l": "a quinone + H2O + sulfite => a quinol + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202137", "l": "AKT1 binds eNOS complex via HSP90 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196417", "l": "Reduction of desmosterol to cholesterol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44042", "l": "14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398188", "l": "PLC beta is activated by G alpha (q) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807106", "l": "PTEN undergoes monoubiquitination (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938930", "l": "RUNX1 binds ELF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48322", "l": "ganglioside Fuc-GA1 + GDP + H(+) => ganglioside GA1 + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756470", "l": "N binds to heme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65638", "l": "CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine => sphinga-(4E,8E)-dienine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389762", "l": "Phosphorylation of PD-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72312", "l": "glutathione(in) + taurocholate(out) => glutathione(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176517", "l": "SULTs transfer (SO4)2- group to PREG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9656244", "l": "DRD2 binds DA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19172", "l": "L-serine <=> NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24189", "l": "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) => 1,2-dihydroxydibenzothiophene + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33301", "l": "[eIF5A protein]-deoxyhypusine + propane-1,3-diamine => [eIF5A protein]-L-lysine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167427", "l": "Opioid dissociates from MOR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669024", "l": "CD70 binds CD27 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22343", "l": "3-hydroxybenzyl alcohol + NADP(+) <=> 3-hydroxybenzaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706837", "l": "AR binds AR antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31500", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54250", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9623384", "l": "α1-agonists bind ADRA1A,B,D (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24690", "l": "acetate + eugenol + NADP(+) = (E)-coniferyl acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24117", "l": "(2E)-geranyl diphosphate + H2O => (S)-linalool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013145", "l": "RAC1 binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61530", "l": "a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55337", "l": "a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine => a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005169", "l": "neurotrophin TRKB receptor binding", "d": ["Binding to a neurotrophin TRKB receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853429", "l": "PHLDA1 binds AURKA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62770", "l": "4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39433", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69646", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 <=> (2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4539779", "l": "Collagen type IV binds integrin alpha10beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22784", "l": "(2R)-O-phospho-3-sulfolactate = H(+) + phosphoenolpyruvate + sulfite", "d": []}, {"i": "EC:4.4.1.19", "l": "\"phosphosulfolactate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16195", "l": "a (2R)-2-hydroxycarboxylate + a halide anion + H(+) => an (R)-2-haloacid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23385", "l": "D-cellobiose => beta-D-glucosyl-(1->4)-D-mannopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47547", "l": "trans-4-hydroxy-L-proline betaine <=> cis-4-hydroxy-D-proline betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19755", "l": "AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+) => ATP + diphthine-[translation elongation factor 2] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018814", "l": "RHOT1 hydrolyzes GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11904", "l": "2-amino-4-hydroxypteridine + H(+) + H2O = 2,4-dihydroxypteridine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167056", "l": "SHC binds to the activated TrkA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42321", "l": "a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56759", "l": "5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58252", "l": "H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] = ADP-D-ribose + L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691004", "l": "XPC binds RAD23 and CETN2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28431", "l": "D-allose 6-phosphate => D-allulose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19652", "l": "ATP + L-aspartate + tRNA(Asp) <=> AMP + diphosphate + L-aspartyl-tRNA(Asp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201443", "l": "Type II receptor phosphorylates type I receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63921", "l": "octadecanoyl-CoA + sphinga-4E,14Z-dienine => CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938853", "l": "CDK6 binds RUNX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648017", "l": "EML4 binds to microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72545", "l": "2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in) => 2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031803", "l": "Maresin-like SPMs translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913371", "l": "GM-CSF receptor alpha:GM-CSF binds Bc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39031", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59034", "l": "4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => (Z)-24-ethylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71012", "l": "L-isoleucine(in) + L-phenylalanine(out) => L-isoleucine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793066", "l": "TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797961", "l": "CHDH oxidises Cho to BETALD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74328", "l": "O-propanoyl-(R)-carnitine(in) => O-propanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004121", "l": "cystathionine beta-lyase activity", "d": ["Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141437", "l": "Formation of the MCC complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.152", "l": "\"mannosylglycoprotein endo-beta-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62830", "l": "GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879907", "l": "Tyrosine kinases phosphorylate the receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45743", "l": "2-oxoglutarate + L-ectoine + O2 <=> 5-hydroxyectoine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17989", "l": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592387", "l": "Fibulin binds elastic fibres (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48530", "l": "ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate => ganglioside GP1c (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35460", "l": "cholesterol + NAD(+) => cholest-5-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140341", "l": "phosphatidylethanolamine floppase activity", "d": ["Catalysis of the movement of phosphatidylethanolamine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668545", "l": "NIK autophosphorylates on T559 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0070002", "l": "glutamic-type peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218820", "l": "Src kinases phosphorylate VAV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53420", "l": "8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine = H(+) + roseoflavin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36636", "l": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665405", "l": "ERBB2 ECD mutants bind trastuzumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55648", "l": "2-oxoglutarate + O2 + validoxylamine A = CO2 + H(+) + succinate + validoxylamine B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351323", "l": "Release of 78 kDa glucose-regulated protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35215", "l": "H2O + XDP = H(+) + phosphate + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62506", "l": "3-amino-5-hydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate => 3-amino-5-hydroxybenzoate + ATP + holo-[aryl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610026", "l": "Defective GALK1 does not phosphorylate Gal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68016", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H2O = (2E,6E,10E)-geranylgeraniol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64192", "l": "H2O + N-(9Z-octadecenoyl)-L-lysine = (9Z)-octadecenoate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14520", "l": "(E)-feruloyl-CoA + H2O <=> 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38520", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71821", "l": "L-thyroxine(in) => L-thyroxine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71299", "l": "chloride(out) + L-isoleucine(out) + 2 Na(+)(out) = chloride(in) + L-isoleucine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23121", "l": "a dipeptide(out) + ATP + H2O => a dipeptide(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36010", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34810", "l": "(R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase] <=> camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.9", "l": "\"adenosylhomocysteine nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174444", "l": "Formation of C-strand Okazaki fragments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244404", "l": "botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182876", "l": "Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-435244", "l": "PECAM1 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17129", "l": "ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate", "d": []}, {"i": "EC:6.3.5.3", "l": "\"phosphoribosylformylglycinamidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351341", "l": "Exocytosis of Proactivator polypeptide (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9709547", "l": "ESTG binds ESR2:chaperone complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59634", "l": "D-xylobiono-1,5-lactone + H2O2 => D-xylobiose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22487", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate <=> GMP + GTP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686359", "l": "SFTPs translocate from extracellular region to clathrin-coated vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848250", "l": "ACBD6 binds LCFA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69820", "l": "H(+) + hypotaurine + NADPH + O2 => H2O + NADP(+) + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215295", "l": "USP7 deubiquitinates MDM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65336", "l": "chrodrimanin T + H(+) + NADPH + O2 = chrodrimanin A + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48702", "l": "a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13589", "l": "3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.4.1.4", "l": "\"methylcrotonoyl-CoA carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66126", "l": "(2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate => 2-oxobutanoate + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28097", "l": "di-trans,octa-cis-undecaprenyl diphosphate + H2O <=> di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950778", "l": "p-Y693-STAT4 dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24191", "l": "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) <=> 1,2-dihydroxydibenzothiophene + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2468040", "l": "Cohesin binds PDS5 and WAPAL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3595176", "l": "Defective CHSY1 does not transfer GalNAc to chondroitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754745", "l": "IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981610", "l": "Neuroglobin binds oxygen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18239", "l": "3-maleylpyruvate + H(+) => 2,5-dihydroxybenzoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21032", "l": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.17", "l": "\"glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37274", "l": "ATP + H2O + L-alanyl-L-glutamine(out) <=> ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44084", "l": "ATP + CoA + heptadecanoate = AMP + diphosphate + heptadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58276", "l": "6 ATP = cyclic hexaadenylate + 6 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807585", "l": "BPI binds LPS on the bacterial surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008043", "l": "MAPK8 phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52296", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48337", "l": "a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35220", "l": "8-oxo-dADP + H2O => 8-oxo-dAMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15541", "l": "DIMBOA + UDP-alpha-D-glucose = DIMBOA beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982775", "l": "Growth hormone receptor dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35570", "l": "H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine <=> (9Z,12Z)-octadecadienoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29825", "l": "chloride(out) => chloride(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64435", "l": "H(+)(out) + L-alanyl-L-prolylglycine(out) <=> H(+)(in) + L-alanyl-L-prolylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019807", "l": "aspartoacylase activity", "d": ["Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404142", "l": "atROL binds RBP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48112", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68106", "l": "(3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone => all-trans-zeaxanthin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46294", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate => a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6790454", "l": "SUMOylation of XPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13587", "l": "ADP + butanoyl phosphate => ATP + butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62432", "l": "a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44568", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) = 2-all-trans-hexaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928604", "l": "SFKs phosphorylate VAV2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985343", "l": "RUNX2 binds SOX9 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702508", "l": "FLT mutants bind type I TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49365", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) => 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102174", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015097", "l": "mercury ion transmembrane transporter activity", "d": ["Enables the transfer of mercury (Hg) ions from one side of a membrane to the other."]}, {"i": "RHEA:32815", "l": "Hg(2+)(in) = Hg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26514", "l": "cyclohexan-1,2-dione + H2O = 6-oxohexanoate + H(+)", "d": []}, {"i": "EC:3.7.1.11", "l": "\"cyclohexane-1,2-dione hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934690", "l": "LIFR gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39509", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+) => 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021450", "l": "PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0140318", "l": "protein transporter activity", "d": ["Directly binding to a specific protein and delivering it to a specific cellular location."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782138", "l": "ERCC5 and RPA bind TC-NER site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102741", "l": "paraxanthine:S-adenosyl-L-methionine 3-N-methyltransferase activity", "d": ["Catalysis of the reaction: 1,7-dimethylxanthine + S-adenosyl-L-methionine <=> H+ + caffeine + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52100", "l": "5-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47498", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADPH => lithocholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665417", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421454", "l": "Transport of protoporphyrin IX from the mitochondrial intermembrane space into the mitochondrial matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008691", "l": "3-hydroxybutyryl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72043", "l": "L-glutamate(in) + orotate(out) = L-glutamate(out) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75524", "l": "acetyl-CoA + S-methyl-L-cysteine => CoA + H(+) + N-acetyl-S-methyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35649", "l": "3',3'-cGAMP + 2 diphosphate => ATP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.714190742181266", "identifiers": [{"i": "GO:0003723", "l": "RNA binding", "d": ["Binding to an RNA molecule or a portion thereof."]}, {"i": "REACT:R-HSA-203922", "l": "Exportin-5 recognizes 3' overhang of pre-miRNA  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45885", "l": "12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58120", "l": "ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2545196", "l": "FN1 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52522", "l": "20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72128", "l": "agmatine(in) + H(+)(out) => agmatine(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677051", "l": "Formation of the PCAF-ATAC complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016797", "l": "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters."]}, {"i": "EC:3.1.16.-", "l": "\"Exonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35266", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013992", "l": "TRAF3 binds to TRIF:activated TLR3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0015203", "l": "polyamine transmembrane transporter activity", "d": ["Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9774195", "l": "ZC3H12A binds CDH19 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40298", "l": "ATP + CoA + hexadecanedioate <=> AMP + diphosphate + hexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17711", "l": "4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-nonaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52557", "l": "3-dehydro-D-erythronate + ATP => 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24205", "l": "acetyl phosphate + H(+) + sulfite => phosphate + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.-", "l": "\"Peroxidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800315", "l": "MST1 binds MST1R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49364", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) = 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948612", "l": "miR-19b microRNA binds CNOT6L mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64940", "l": "dGDP + H2O = dGMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66006", "l": "Co(I)-[glycine betaine-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[glycine betaine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54843", "l": "H(+) + NADPH + O2 + octan-3-one <=> H2O + NADP(+) + pentyl propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50763", "l": "a quinone + H2O + sulfite <=> a quinol + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54875", "l": "(1S,4R)-menthone + H(+) + NADPH + O2 <=> (4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "59.278543615428916", "identifiers": [{"i": "GO:0016462", "l": "pyrophosphatase activity", "d": ["Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups."]}, {"i": "REACT:R-HSA-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20451", "l": "5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+) => 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761027", "l": "ZEB2 binds SP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693783", "l": "NAALADases hydrolyse NAAG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.10", "l": "\"enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18803", "l": "(cis-prenyl)(n+1)-diphosphate + diphosphate => (cis-prenyl)n-diphosphate + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59607", "l": "H2O + O2 + spermidine <=> H2O2 + N-(4-aminobutyl)-3-aminopropanal + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047089", "l": "dihydrochelirubine 12-monooxygenase activity", "d": ["Catalysis of the reaction: dihydrochelirubine + H+ + NADPH + O2 = 12-hydroxydihydrochelirubine + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48576", "l": "4-chlorocatechol + O2 = 3-chloro-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45008", "l": "H2O + N-(octadecanoyl)-sphinganine = octadecanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032775", "l": "YAP1 binds TEAD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141159", "l": "TNF-mediated dimerization of procaspase-8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222128", "l": "NOC2L binds TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73808", "l": "GDP + S-adenosyl-L-methionine => N(7)-methyl-GDP + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71985", "l": "diphosphate + fusoxypene B => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050319", "l": "tartrate decarboxylase activity", "d": ["Catalysis of the reaction: L-tartrate + H+ = D-glycerate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592316", "l": "Initial activation of proMMP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640862", "l": "Tankyrase binds AXIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28843", "l": "choline(in) + H(+)(in) = choline(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39794", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19739", "l": "4-aminobutanoate + L-glutamate => 4-(gamma-L-glutamylamino)butanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12066", "l": "glutarate + 2 H(+) + NADH => 5-oxopentanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6790038", "l": "Expression of HSP90B1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21642", "l": "3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH => NADP(+) + prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64208", "l": "an N-(fatty acyl)-L-glutamine + H2O = a fatty acid + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48412", "l": "globoside IV3GalNAc-Gb4Cer + H2O = globoside Gb4Cer + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49463", "l": "(2Z,4E)-2-aminomuconate + H2O <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32953", "l": "trehalulose => sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12258", "l": "CO2 + L-tyrosine + NADH => L-arogenate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112379", "l": "Recruitment of elongation factors to form elongation complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43577", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166362", "l": "Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15845", "l": "4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose = 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP", "d": []}, {"i": "EC:2.4.1.52", "l": "\"poly(glycerol-phosphate) alpha-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29079", "l": "(R)-lactate + ubiquinone-8 = pyruvate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34209", "l": "beta-D-glucose 1-phosphate + L-rhamnopyranose => 3-O-alpha-D-glucosyl-L-rhamnose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54272", "l": "2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39319", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29830", "l": "Mg(2+)(in) <=> Mg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032781", "l": "WWTR1 (TAZ) binds TEAD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63402", "l": "Fe(II)-heme a + H2O => Fe(II)-hydroxyheme i", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55042", "l": "3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP] => (9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70847", "l": "L-arginine(in) + L-cysteine(out) + Na(+)(out) = L-arginine(out) + L-cysteine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39028", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28607", "l": "L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31755", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + H2O = 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde", "d": []}, {"i": "EC:3.3.2.12", "l": "\"oxepin-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34182", "l": "H2O + mycophenolic acid O-acyl-beta-D-glucuronide <=> D-glucuronate + H(+) + mycophenolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48080", "l": "abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase] = ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.175", "l": "\"ferruginol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18728", "l": "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA <=> acetyl-CoA + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46067", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60114", "l": "(E)-3-(indol-3-yl)acryloyl-CoA + H2O => (R)-3-(indol-3-yl)lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62367", "l": "FMN-N(5)-peroxide + thymine <=> (Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388596", "l": "Melanocortin receptors bind melanocortins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21243", "l": "geranylgeranyl diphosphate + L-cysteinyl-[protein] <=> diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14582", "l": "H(+) + 2 monodehydro-L-ascorbate radical + NADH => 2 L-ascorbate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9680443", "l": "ROCK1,2 bind ROCKi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43978", "l": "14-hydroxyhexadecanoate + H2O + NADP(+) => H(+) + hexadecanoate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10122", "l": "inosine in double-stranded RNA + NH4(+) => adenosine in double-stranded RNA + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68957", "l": "S-adenosyl-L-methionine + scopoletin => H(+) + S-adenosyl-L-homocysteine + scoparone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10855", "l": "dimethylallyl diphosphate + leachianone G <=> diphosphate + sophoraflavanone G", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40467", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61205", "l": "L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal => H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53200", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11508", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 = 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.16", "l": "\"peptide-aspartate beta-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170986", "l": "Ral-GDS binds to Ras-GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433415", "l": "Activation of RAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54743", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65823", "l": "decanoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> dec-9-enoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675198", "l": "Activated MAPKs phosphorylate BRAF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69928", "l": "adenosine(out) + Na(+)(out) => adenosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391936", "l": "EP1 receptor can bind PGE2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.95", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001786", "l": "phosphatidylserine binding", "d": ["Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74232", "l": "H2O + L-threonyl-tRNA(Val) => L-threonine + tRNA(Val)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10699", "l": "a long-chain fatty acid + ATP + holo-[mycocerosate synthase] <=> AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63403", "l": "Fe(II)-hydroxyheme i <=> Fe(II)-heme a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373342", "l": "CX3CR1 binds CX3CL1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0009669", "l": "sucrose:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + monovalent cation(out) = sucrose(in) + monovalent cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9010815", "l": "SLITs bind keratan sulfate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54267", "l": "2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2186780", "l": "Degradation of Ub-SMAD7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5658435", "l": "RAS GAPs bind RAS:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2752125", "l": "SPP1 (osteopontin) binds integrins alphaVbeta1, alphaVbeta3, alphaVbeta5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47235", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0016715", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor."]}, {"i": "EC:1.14.17.-", "l": "\"With reduced ascorbate as one donor, and incorporation of one atom of oxygen\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044685", "l": "tetrahydromethanopterin-dependent serine hydroxymethyltransferase activity", "d": ["Catalysis of the reaction: tetrahydromethanopterin + L-serine = 5,10-methylenetetrahydromethanopterin + glycine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36597", "l": "NADPH + sulfur => hydrogen sulfide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39446", "l": "(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75347", "l": "thiocyanate(in) = thiocyanate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58770", "l": "1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139941", "l": "Binding of IP3 to IP3 receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36117", "l": "O-methyl gibberellin A3 + S-adenosyl-L-homocysteine => gibberellin A3 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44243", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014467", "l": "RHOG binds effectors at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69603", "l": "UTP = 3',5'-cyclic UMP + diphosphate", "d": []}, {"i": "EC:4.6.1.26", "l": "\"uridylate cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28495", "l": "a menaquinone + dimethyl sulfide + H2O => a menaquinol + dimethyl sulfoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68642", "l": "diphosphate + limonene => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636658", "l": "esxA binds PGK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684096", "l": "CDK2 phosphorylates RBBP8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805205", "l": "GPR35 binds kynurenic acid (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033440", "l": "ACG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an ACG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20563", "l": "CO2 + glycolaldehyde => 3-hydroxypyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.203", "l": "\"tRNA (cytosine(34)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54961", "l": "ATP + CoA + dinor-OPDA => AMP + dinor-OPDA-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23887", "l": "nicotinamide + S-adenosyl-L-methionine <=> 1-methylnicotinamide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.104", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660753", "l": "SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948757", "l": "AKT phosphorylates MKRN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15919", "l": "aldono-1,5-lactone + H(+) + NADH => an aldopyranose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14339", "l": "adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate => 3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42632", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.224", "l": "\"23S rRNA (adenine(2503)-C(8))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69655", "l": "H2O + quercetin 3-O-beta-D-glucoside = beta-D-glucose + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35328", "l": "eicosanoyl-CoA + H(+) + malonyl-CoA => 3-oxodocosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043014", "l": "alpha-tubulin binding", "d": ["Binding to the microtubule constituent protein alpha-tubulin."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052924", "l": "all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70100", "l": "H(+) + o-quinone methide + peniphenone D => penilactone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21270", "l": "berberine + H(+) + 2 NADPH => (R)-canadine + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13194", "l": "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466706", "l": "Defective OPN1MW causes DCB and BCM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21239", "l": "anthranilate + 2 H(+) + NADPH + O2 <=> 2,3-dihydroxybenzoate + NADP(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40907", "l": "2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41542", "l": "8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine => 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18971", "l": "a long-chain alkane + CO2 => a long-chain fatty acid + H(+) + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35737", "l": "a 2-oxocarboxylate + H(+) + NADPH => a (2R)-2-hydroxycarboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18402", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72180", "l": "Cleavage of mRNA at the 3'-end (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800315", "l": "MST1 binds MST1R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35498", "l": "H2O + N-(4-aminobenzoyl)-L-glutamate <=> 4-aminobenzoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9634834", "l": "ACHEIs bind ACHE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693608", "l": "Initial resection of double-strand break ends (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2201341", "l": "Endocytosis of TRAM (TICAM2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22987", "l": "carbamoyl phosphate + oxamate <=> N-carbamoyl-2-oxoglycine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938356", "l": "RMB14 binds RUNX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15104", "l": "H(+) + meso-2,6-diaminoheptanedioate <=> CO2 + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852716", "l": "Thrombin, ELANE cleave C5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357483", "l": "RAC1 binds PAK1-3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018768", "l": "RHOU auto-activates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004126", "l": "cytidine deaminase activity", "d": ["Catalysis of the reaction: cytidine + H2O = uridine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6795667", "l": "MDM2 translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.4", "l": "\"chloroplast protein-transporting ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6790038", "l": "Expression of HSP90B1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56572", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose = globoside Gb3Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174058", "l": "Degradation of multiubiquitinated Cdh1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24318", "l": "(+)-copalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48960", "l": "[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50139", "l": "ethyl (9Z)-octadecenoate + H2O <=> (9Z)-octadecenoate + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51870", "l": "demethylsuberosin + diphosphate => dimethylallyl diphosphate + umbelliferone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49264", "l": "5-O-[(E)-caffeoyl]-shikimate + H2O = (E)-caffeate + H(+) + shikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2562541", "l": "TLR4-induced ripoptosome assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784765", "l": "p-Y705-STAT3 dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044688", "l": "7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity", "d": ["Catalysis of the reaction: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22236", "l": "2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate", "d": []}, {"i": "EC:3.1.3.68", "l": "\"2-deoxyglucose-6-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65838", "l": "A + ADP + 2 Co(I)-[trimethylamine-specific corrinoid protein] + 3 H(+) + phosphate => AH2 + ATP + 2 Co(II)-[trimethylamine-specific corrinoid protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15660", "l": "1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) <=> 3-methylcatechol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58919", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + squalene <=> (S)-2,3-epoxysqualene + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202111", "l": "AKT1 phosphorylates eNOS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700168", "l": "Active ALK phosphorylates IRS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46933", "l": "2-epi-5-epi-valiolone 7-phosphate => 5-epi-valiolone 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050683", "l": "AF-1 domain binding", "d": ["Binding to an AF-1 protein domain, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0000702", "l": "oxidized base lesion DNA N-glycosylase activity", "d": ["Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417890", "l": "P2Y5 receptor can bind to LPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36978", "l": "AMP + phosphate <=> adenine + alpha-D-ribose 1,5-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73683", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphing-4-enine = a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43976", "l": "H(+) + hexadecanoate + NADPH + O2 = 14-hydroxyhexadecanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18751", "l": "[protein]-disulfide + H(+) + NADH => [protein]-dithiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14846", "l": "L-aspartate 4-semialdehyde + pyruvate => (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42733", "l": "guanosine(527) in 16S rRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162657", "l": "Inactivation of Myt1 kinase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17120", "l": "ATP + L-glutamate + methylamine <=> ADP + H(+) + N(5)-methyl-L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32507", "l": "4-isopropenyl-7-methyloxepan-2-one + H2O = 6-hydroxy-3-isopropenylheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14134", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43913", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47567", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GA2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336443", "l": "LIN7, CASK and APBA1 bind (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417898", "l": "P2Y4 receptor can bind to UTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1248655", "l": "Trans-autophosphorylation of EGFRvIII mutant dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33673", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2 => an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111237", "l": "Formation of ADAR1 homodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11356", "l": "A + H(+) + NADH = AH2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684140", "l": "ATM phosphorylates RBBP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23107", "l": "D-arabinose 5-phosphate <=> D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36490", "l": "agmatine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2167942", "l": "Collagen type XIII ectodomain shedding (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42317", "l": "a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956659", "l": "ABL1 phosphorylates YAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62826", "l": "beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+) => beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193700", "l": "p75NTR ICD signals to NF-kB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50405", "l": "(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] => 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956639", "l": "RUNX1 binds YAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211193", "l": "Homodimerization  of DFF40 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19486", "l": "sphing-4-enine + UDP-alpha-D-galactose => beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38641", "l": "1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69068", "l": "RFC dissociates after sliding clamp formation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62748", "l": "H2O + lovastatin = (S)-2-methylbutanoate + H(+) + monacolin J", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45235", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH <=> a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9818937", "l": "MEN1 binds MLL1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27353", "l": "4'-demethylrebeccamycin + S-adenosyl-L-methionine = H(+) + rebeccamycin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.164", "l": "\"demethylrebeccamycin-D-glucose O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37372", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O => a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44988", "l": "(R)-carnitine + 2-methylpropanoyl-CoA = CoA + O-isobutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0035368", "l": "selenocysteine insertion sequence binding", "d": ["Binding to a selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467811", "l": "Separation of sister chromatids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73657", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + N-methylmyosmine => (S)-nicotine + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51439", "l": "acetyl-CoA + D-alanine <=> (2R)-2-amino-4-oxopentanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416530", "l": "FFAR1:FFAR1 ligands activates Gq (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35923", "l": "neamine + UDP-alpha-D-glucose = 3''-deamino-3''-hydroxykanamycin B + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74539", "l": "creatinine(in) = creatinine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33857", "l": "a mannosylinositol-1-phosphophytoceramide + GDP + H(+) => an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225952", "l": "Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0030283", "l": "testosterone dehydrogenase [NAD(P)] activity", "d": ["Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139919", "l": "Translocation of BIM to mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050362", "l": "L-tryptophan:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-tryptophan + 2-oxoglutarate = indolepyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624120", "l": "CEBPA binds CDK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45135", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14567", "l": "3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP] => (11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432897", "l": "ILK interacts with beta-1 integrin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33430", "l": "(S)-malyl alpha-D-glucosaminide + L-cysteine <=> bacillithiol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14972", "l": "S-adenosyl-L-methionine + trans-aconitate <=> (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140226", "l": "RNA topoisomerase activity", "d": ["Catalysis of the transient cleavage and passage of individual RNA strands or double helices through one another, resulting a topological transformation in RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371518", "l": "SIRT1 binds to HSF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42885", "l": "(R)-mevalonate + ATP => (R)-3-phosphomevalonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034873", "l": "thioacetamide S-oxygenase activity", "d": ["Catalysis of the reaction: thioacetamide + O2 + 2 H+ + 2 e- = thioacetamide S-oxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40455", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA = (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47308", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209102", "l": "SLMB binds to phosphorylated ARM to form the 'destruction complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59258", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) => Fe(III)-enterobactin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18551", "l": "[(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP => [(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58602", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine => 2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45737", "l": "(3E)-hexenoyl-CoA => (2E)-hexenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29552", "l": "H2O + UDP-alpha-D-glucose => alpha-D-galactose 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58911", "l": "7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH <=> C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12127", "l": "4-coumaroyl-CoA + shikimate <=> CoA + trans-4-coumaroylshikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56747", "l": "2-oxoglutarate + L-arginyl-[protein] + O2 <=> (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43614", "l": "5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(341) in tmRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432909", "l": "Interaction of Plectin with Integrin beta 4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10713", "l": "L-phenylalanine + O2 => 2-phenylacetamide + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65199", "l": "H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine <=> H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31908", "l": "(S)-norcoclaurine + S-adenosyl-L-methionine => (S)-coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34177", "l": "4-hydroxycoumarin + CO2 + 2 CoA => 2-hydroxybenzoyl-CoA + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22473", "l": "(R)-pantetheine + ATP => (R)-4'-phosphopantetheine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51394", "l": "CoA + H(+) + N-(9Z-octadecenoyl)-serotonin => (9Z)-octadecenoyl-CoA + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57877", "l": "uridine(54) in tRNA => pseudouridine(54) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-421835", "l": "trans-Golgi Network Vesicle Scission (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13050", "l": "D-glucuronate => D-fructuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610722", "l": "CK1 phosphorylates p-GLI3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323184", "l": "Defective HLCS does not biotinylate ACACA:Mn2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73491", "l": "Co(2+)(out) + 2 hydrogencarbonate(out) = Co(2+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.45", "l": "\"helper-component proteinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72426", "l": "(E)-4-coumaroyl-AMP + CoA <=> (E)-4-coumaroyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660192", "l": "VDR agonists bind VDR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389862", "l": "Conversion of glyoxylate to oxalate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10915", "l": "(R)-pantoate + ATP + beta-alanine <=> (R)-pantothenate + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9705926", "l": "AR binds AR agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468040", "l": "Cohesin binds PDS5 and WAPAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49200", "l": "D-mannose 6-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate", "d": []}, {"i": "EC:2.5.1.132", "l": "\"3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10050", "l": "acetate + H(+) + L-methionine => methanethiol + O-acetyl-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033779", "l": "5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity", "d": ["Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + H+ + NADPH + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52747", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + H2O <=> alpha-isomaltosyl-(1->3)-isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39065", "l": "H(+) + NADPH + scyllo-inosose => NADP(+) + scyllo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168412", "l": "MDP elicits a NOD2 response (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809680", "l": "MTMR12 binds MTM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63727", "l": "candesartan + UDP-alpha-D-glucuronate <=> candesartan O-beta-D-glucuronoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008822", "l": "PPM1D dephosphorylates RUNX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62545", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabagenin => dihydroouabagenin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18087", "l": "coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine => coenzyme B + coenzyme M + methanophenazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733973", "l": "Bile salts bind FABP6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18550", "l": "[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399711", "l": "Activation of Ca impermeable AMPA receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63266", "l": "1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37209", "l": "1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2395517", "l": "NADPH transfers electrons to FDXR (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43631", "l": "L-serine + NAD(+) <=> aminoacetaldehyde + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429992", "l": "PARN deadenylates mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29001", "l": "H(+)(in) + homoserine lactone(out) => H(+)(out) + homoserine lactone(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74380", "l": "2 (S)-lactate(in) + prostaglandin H2(out) => 2 (S)-lactate(out) + prostaglandin H2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754537", "l": "SARS-CoV-2 3a tetramer binds to VPS39 within HOPS complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862771", "l": "PLA2G2A binds bacterial phospholipids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392513", "l": "Rap1 signal termination by Rap1GAPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43327", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691131", "l": "CANDI binds CUL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63027", "l": "(13Z)-docosenamide + H2O <=> (13Z)-docosenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18683", "l": "phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine => phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167047", "l": "pro-beta-NGF dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38802", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660666", "l": "CBP and p300 binds NF-kB complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688834", "l": "ATXN3 binds VCP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38402", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O <=> (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74630", "l": "NADPH + 2 O2 + prefumagillin <=> acetaldehyde + fumagillin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22230", "l": "diphosphate + NAD(+) + squalene => H(+) + NADH + presqualene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60731", "l": "citral + H2O + NADP(+) <=> 3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018754", "l": "GDIs bind RHOH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46199", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] <=> 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25282", "l": "O2 + reduced [NADPH--hemoprotein reductase] + squalene = (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.17", "l": "\"squalene monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388814", "l": "Grb2 binds CD28 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53663", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15583", "l": "biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA => biochanin A 7-O-beta-D-glucoside + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218804", "l": "p38 MAPK activation by VEGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71082", "l": "cordypyrone A + O2 + reduced [NADPH--hemoprotein reductase] <=> cordypyrone B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51273", "l": "(9Z)-octadecenoyl-CoA + glycine => CoA + H(+) + N-(9Z-octadecenoyl)glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41576", "l": "dTDP-beta-L-mycarose + erythronolide B = 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.328", "l": "\"erythronolide mycarosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50753", "l": "2 naphthalene-1,2,4,8-tetrol + O2 => 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29640", "l": "D-maltohexaose + H2O => alpha-D-glucose + D-maltopentaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163402", "l": "diacylglycerol + H2O -> 2-acylglycerol + fatty acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37726", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46386", "l": "24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622382", "l": "PIP2 hydrolysis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45893", "l": "an N-acylsphing-4-enine + CDP-ethanolamine => an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41435", "l": "3-methyl-L-tyrosine + H2O2 <=> 5-hydroxy-3-methyl-L-tyrosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47219", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202947", "l": "Caspase mediated cleavage of APC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74472", "l": "(-)-4'-methoxycyclopeptine + 2-oxoglutarate + O2 => (Z)-4'-methoxydehydrocyclopeptine + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661517", "l": "LUBAC binds OTULIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196017", "l": "Dynamin is recruited to the gap junction plaque (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29642", "l": "D-maltohexaose + H2O <=> alpha-D-glucose + D-maltopentaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19721", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.1", "l": "\"stearoyl-CoA 9-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75915", "l": "H2O + NAD(+) + serinol = dihydroxyacetone + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018755", "l": "2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity", "d": ["Catalysis of the reaction: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71472", "l": "H2O + substance P => L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50836", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5591086", "l": "SERPINA5 binds activated protein C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55671", "l": "11-cis-retinol--[retinol-binding protein] + NAD(+) <=> 11-cis-retinal--[retinol-binding protein] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694529", "l": "Ubiquination of protein E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29788", "l": "ATP + glutathione(in) + H2O => ADP + glutathione(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15309", "l": "(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.7.5", "l": "\"phycocyanobilin:ferredoxin oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044548", "l": "S100 protein binding", "d": ["Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.430", "l": "\"D-xylose reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509831", "l": "ITPA hydrolyses XTP to XMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14024", "l": "AH2 + ecdysone + O2 <=> 20-hydroxyecdysone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9761027", "l": "ZEB2 binds SP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793887", "l": "TBX6 and LEF1:CTNNB1 bind the DLL1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73892", "l": "MGMT/hAGT mediated DNA Damage Reversal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004819", "l": "glutamine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73757", "l": "Binding of RRN3 to RNA Polymerase I (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16920", "l": "2,6-dihydroxypyridine + H(+) + NADH + O2 <=> 2,3,6-trihydroxypyridine + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139842", "l": "Binding of Syk tyrosine kinase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34032", "l": "2'-N-acetylparomamine + H2O => acetate + paromamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44438", "l": "a triacylglycerol + glycerol => a 1,2-diacylglycerol + a 1-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33576", "l": "an inositol-1-phosphophytoceramide + beta-D-mannose => a mannosylinositol-1-phosphophytoceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654515", "l": "KAL1 binds HS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63963", "l": "abscisate(out) + ATP + H2O <=> abscisate(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.16", "l": "\"tRNA-intron lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373746", "l": "SEMA4D interacts with CD45 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013006", "l": "RHOA:GTP translocates to the ER membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11621", "l": "H2O + L-2-amino-4-chloropent-4-enoate => 2-oxopent-4-enoate + chloride + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12582", "l": "H(+) + NADH + pyruvate + taurine => H2O + NAD(+) + tauropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73870", "l": "serotonin(out) <=> serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56131", "l": "A + dimethylallyl diphosphate + H2O + nonaflavuxanthin <=> AH2 + diphosphate + flavuxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37462", "l": "1D-myo-inositol hexakisphosphate + ATP <=> 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17540", "l": "(R)-carnitinamide + H2O <=> (R)-carnitine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48544", "l": "[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.233", "l": "\"[phosphatase 2A protein]-leucine-carboxy methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.200", "l": "\"tetracenomycin A2 monooxygenase-diooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111915", "l": "CAMK4 autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58965", "l": "H2O + hexanal + O2 => H(+) + H2O2 + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868118", "l": "MAPK12 phosphorylates PTPN3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75934", "l": "H2O + taurocyamine <=> taurine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74832", "l": "UDP-alpha-D-glucuronate(out) + UDP-alpha-D-xylose(in) => UDP-alpha-D-glucuronate(in) + UDP-alpha-D-xylose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60453", "l": "2-hydroxyethane-1-sulfonate => acetaldehyde + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32938", "l": "a cardiolipin + H2O <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928615", "l": "EFNBs bind SFKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25828", "l": "AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2 = A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368588", "l": "DVL binds CCDC88C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71808", "l": "a 2'-deoxyguanosine in DNA + NAD(+) => an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22153", "l": "a ubiquinone + D-glucose => a ubiquinol + D-glucono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13158", "l": "(R)-glycerate + CO2 + NADP(+) => 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20448", "l": "L-arogenate + oxaloacetate <=> L-aspartate + prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70527", "l": "H(+) + N-acyl-3-oxosphinganine + NADH = an N-acylsphinganine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114553", "l": "Activation of conventional Protein Kinase C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805399", "l": "TAF1 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3132759", "l": "TCN1 binds RCbl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432121", "l": "LDL binds to LRP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61734", "l": "H(+) + steviolmonoside + UDP => steviol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696268", "l": "RND3 binds effectors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043287", "l": "poly(3-hydroxyalkanoate) binding", "d": ["Binding to a poly(3-hydroxyalkanoate), a polyester of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35665", "l": "a 1-acyl-sn-glycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010355", "l": "homogentisate farnesyltransferase activity", "d": ["Catalysis of the reaction: homogentisic acid + farnesyl diphosphate = 2-methyl-6-farnesylplastoquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682863", "l": "RNF168 binds DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29503", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + patchoulol", "d": []}, {"i": "EC:4.2.3.70", "l": "\"patchoulol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002428", "l": "Removal of fibrillar collagen N-propeptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34772", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) => a 3-oxosteroid + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39117", "l": "4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH => 4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56444", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10818", "l": "L-fucose + methyl beta-D-galactoside => H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420265", "l": "AMY1-3 bind IAPP(34-70) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-912734", "l": "CBL:CRKL binds RAPGEF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420117", "l": "VEGFR2 autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38709", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.49", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814088", "l": "SYS1 binds AcM-ARFRP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23419", "l": "(2R)-O-phospho-3-sulfolactate + H2O <=> (2R)-3-sulfolactate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44058", "l": "2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA => 2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43034", "l": "2-aminoprop-2-enoate + chloride + H(+) => 3-chloro-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34562", "l": "1-deoxy-11beta-hydroxypentalenate + NAD(+) <=> 1-deoxy-11-oxopentalenate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70982", "l": "Fumarate + H2O <=> (S)-Malate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49498", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane => 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428625", "l": "Vesicular inhibitory amino acid transport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64157", "l": "an N-(fatty acyl)-L-methionine + H2O => a fatty acid + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65079", "l": "dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450488", "l": "BRF1 Complex recruits RNA degradation activities (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17526", "l": "biuret + H2O => NH4(+) + urea-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67088", "l": "ATP + H2O + tetracosanoate(in) = ADP + H(+) + phosphate + tetracosanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936659", "l": "PAPS is dephosphorylated to APS (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214880", "l": "DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.843050782660015", "identifiers": [{"i": "GO:0008409", "l": "5'-3' exonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56907", "l": "an acyl-AMP + CoA <=> AMP + an acyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10764", "l": "(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 = (4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9757256", "l": "MCM3 binds MCM5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40038", "l": "ATP + L-glutamate + N-acetyl-L-aspartate <=> ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13526", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] => (1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19665", "l": "6-carboxyhexanoyl-CoA + NAD(+) = 6-carboxyhex-2-enoyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.62", "l": "\"pimeloyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371422", "l": "ATP hydrolysis by HSP70 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52422", "l": "phosphate + S-sulfo-L-cysteine => O-phospho-L-serine + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389862", "l": "Conversion of glyoxylate to oxalate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034191", "l": "apolipoprotein A-I receptor binding", "d": ["Binding to an apolipoprotein A-I receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849102", "l": "SRMS phosphorylates PTK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54093", "l": "3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 => 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56805", "l": "2 cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] => 2 cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797553", "l": "Protein 4.1 binds CASK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27666", "l": "(R)-methylmalonyl-CoA + H(+) = CO2 + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17819", "l": "H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => (3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45424", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109639", "l": "Formation of the closed pre-initiation complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67832", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(27)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(27)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24774", "l": "chlorophyllide b + H(+) + NADPH => 7(1)-hydroxychlorophyllide a + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11977", "l": "anhydrotetracycline + H(+) + NADPH + O2 => 5a,11a-dehydrotetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38498", "l": "a triacylglycerol + H2O <=> a 1,3-diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209321", "l": "Phosphorylated STAT92E dissociates from HOP and DOME and dimerises (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.11", "l": "\"gamma-D-glutamyl-meso-diaminopimelate peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854052", "l": "Formation of the SCF-FBXL7 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000824", "l": "inositol tetrakisphosphate 3-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35710", "l": "(2S)-versicolorone + H(+) + NADPH + O2 <=> (3S)-versiconol acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299338", "l": "Activation of TRESK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.60", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16302", "l": "H2O + NAD(+) => ADP-D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60700", "l": "a 1-acyl-sn-glycero-3-phosphocholine = a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050457", "l": "decylcitrate synthase activity", "d": ["Catalysis of the reaction: H2O + lauroyl-CoA + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648017", "l": "EML4 binds to microtubules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75895", "l": "holothin + marinoloyl-CoA C = CoA + thiomarinol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53011", "l": "(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate <=> di-trans,poly-cis-polyprenyl diphosphate + n diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14714", "l": "A + keto-L-sorbose => 5-dehydro-D-fructose + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-190141", "l": "ALAD binds to Pb2+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47696", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53979", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693061", "l": "STAMBP binds STAM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0016300", "l": "tRNA (uracil) methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49337", "l": "2,2-dihydroxyspheroidene => H2O + spheroiden-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67732", "l": "uridylyl-uridylyl-ribonucleotide-RNA = a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61446", "l": "an 11a-hydroxytetracycline + H2O + NADP(+) => a tetracycline + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0016436", "l": "rRNA (uridine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyluridine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045504", "l": "dynein heavy chain binding", "d": ["Binding to a heavy chain of the dynein complex."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047113", "l": "aldehyde dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: an aldehyde + a quinone + H2O = a carboxylate + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60954", "l": "(E)-sinapate + H(+) + S-adenosyl-L-homocysteine => (E)-5-hydroxyferulate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19623", "l": "a nucleoside 3'-phosphate + H(+) => a nucleoside 2',3'-cyclic phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047926", "l": "geranyl-diphosphate cyclase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = (2S)-bornyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34145", "l": "Delta(9)-tetrahydrocannabinolate + H2O2 => cannabinerolate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0008920", "l": "lipopolysaccharide heptosyltransferase activity", "d": ["Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782820", "l": "USP17 deubiquitinates SUDS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69551", "l": "H(+) + O-phospho-L-serine <=> CO2 + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.47", "l": "\"D-ribulokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71307", "l": "chloride(out) + L-valine(out) + 2 Na(+)(out) = chloride(in) + L-valine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31404", "l": "all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) => all-trans-4,4'-diaponeurosporene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50056", "l": "ATP + glycocholate(in) + H2O = ADP + glycocholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849878", "l": "PSD-95 binds NMDA receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67871", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] <=> 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25890", "l": "H(+) + 2 H2O + phosphate + quinolinate => dihydroxyacetone phosphate + iminosuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69074", "l": "Formation of Processive Complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73500", "l": "3',4',7-trihydroxyflavone + S-adenosyl-L-methionine => 4',7-dihydroxy-3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682388", "l": "Autophagosome maturation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75196", "l": "2-dehydro-3-deoxy-D-arabinonate + NAD(+) => 5-hydroxy-2,4-dioxopentanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37455", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647994", "l": "RAS proteins are depalmitoylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52475", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48404", "l": "apo-[aryl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42042", "l": "gangliosideFuc-GM1 (d18:1(4E)) + GDP + H(+) => ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14673", "l": "a polar amino acid(out) + ATP + H2O = a polar amino acid(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16417", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) = H(+) + L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20600", "l": "2 L-cysteine + NAD(+) <=> H(+) + L-cystine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714483", "l": "RAC2 translocates to the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65410", "l": "NAD(+)(out) => NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050113", "l": "inositol oxygenase activity", "d": ["Catalysis of the reaction: myo-inositol + O2 = D-glucuronate + H2O + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63011", "l": "(6Z)-octadecenamide + H2O <=> (6Z)-octadecenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029460", "l": "PAK1 phosphorylates LIMK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68731", "l": "26-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxy-lanosta-8, 24-dien-26-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66679", "l": "(2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide <=> 4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47576", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) = CMP + ganglioside GD1c (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21623", "l": "FMNH2 + NAD(+) <=> FMN + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.319", "l": "\"isoeugenol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54418", "l": "campest-4-en-3-one + H(+) + NADPH => 5alpha-campestan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51012", "l": "a monoacyl-sn-glycero-3-phosphocholine + H2O = a monoacylglycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67020", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.57", "l": "\"methyltransferase cap1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853444", "l": "AURKA phosphorylates PHLDA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49385", "l": "(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12550", "l": "2-cis-(+)-abscisic aldehyde + H(+) + NADH => 2-cis,4-trans-xanthoxin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429683", "l": "CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64340", "l": "(2E,6E)-farnesyl diphosphate + 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one = 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15417", "l": "L-arogenate + NADP(+) = CO2 + L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047261", "l": "steroid N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: estradiol-17alpha 3-D-glucuronoside + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-D-glucosaminyl)-estradiol 3-D-glucuronoside + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19676", "l": "1,2,3-trihydroxybenzene + O2 <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209792", "l": "N-acetylation of serotonin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42168", "l": "20alpha-hydroxy-5beta-pregnan-3-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30446", "l": "2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc <=> 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32095", "l": "acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)", "d": []}, {"i": "EC:2.3.1.197", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15689", "l": "H(+) + L-2,4-diaminobutanoate = CO2 + propane-1,3-diamine", "d": []}, {"i": "EC:4.1.1.86", "l": "\"diaminobutyrate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391941", "l": "BLT receptors can bind LTB4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033428", "l": "CAG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CAG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807585", "l": "BPI binds LPS on the bacterial surface (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64988", "l": "CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68863", "l": "7-oxo-25-hydroxycholesterol + H(+) + NADPH <=> 7beta-25-dihydroxycholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42613", "l": "a plastoquinone + (n+1) H(+)(in) + NADPH => a plastoquinol + n H(+)(out) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59359", "l": "H2O + lactobiono-1,5-lactone <=> H(+) + lactobionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59164", "l": "ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] = AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728776", "l": "SARS-CoV-1 nsp1 binds to RCAN3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6795473", "l": "PDPK1 phosphorylates SGK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17447", "l": "2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21303", "l": "H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9718020", "l": "PTGFR binds PTGFR agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.019725967809748", "identifiers": [{"i": "GO:0016887", "l": "ATP hydrolysis activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62775", "l": "N-acetyl-D-phenylalanine <=> N-acetyl-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31491", "l": "soyasaponin III + UDP-beta-L-rhamnose = H(+) + soyasaponin I + UDP", "d": []}, {"i": "EC:2.4.1.273", "l": "\"soyasaponin III rhamnosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047230", "l": "flavonol-3-O-glucoside L-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: flavonol 3-O-D-glucoside + UDP-L-rhamnose = flavonol 3-O-L-rhamnosylglucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.431", "l": "\"D-xylose reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71396", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate(out) => (5Z,8Z,11Z,14Z)-eicosatetraenoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48559", "l": "4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) <=> 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672957", "l": "PP2A dephosphorylates KSR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38817", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0044620", "l": "ACP phosphopantetheine attachment site binding", "d": ["Binding to the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62917", "l": "an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine => an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429441", "l": "SYK activation by SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59818", "l": "a sterol ester + CoA => a long-chain fatty acyl-CoA + a sterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017921", "l": "OPRM1 gene expression is repressed by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793176", "l": "DS is cleaved from its proteoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18676", "l": "ATP + L-seryl-[receptor-protein] <=> ADP + H(+) + O-phospho-L-seryl-[receptor-protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61566", "l": "a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+) => a tetracycline + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61277", "l": "H2O + L-ornithine + O2 => 5-amino-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031785", "l": "type 1A melatonin receptor binding", "d": ["Binding to a type 1A melatonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15218", "l": "ecdysone + hexadecanoyl-CoA => CoA + ecdysone hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879273", "l": "mycothiol conjugates with electrophilic xenobiotic (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22883", "l": "2-oxoglutarate + L-arogenate <=> L-glutamate + prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32935", "l": "a cardiolipin + H2O = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46965", "l": "lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0003839", "l": "gamma-glutamylcyclotransferase activity", "d": ["Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65646", "l": "CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine => (4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54944", "l": "3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390641", "l": "ADRA1A,B,D bind ADR,NAd (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217209", "l": "Generation of a DNA double strand break (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5213466", "l": "RIPK3 is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47828", "l": "ganglioside GT1b + H2O = ganglioside GD1b + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212614", "l": "Glutamine transport from astrocytes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37074", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32050", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate <=> adenosine 5'-pentaphosphate + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15549", "l": "S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O", "d": []}, {"i": "EC:4.2.1.109", "l": "\"methylthioribulose 1-phosphate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34540", "l": "S-adenosyl-L-methionine + tellurite => methanetellurite + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27839", "l": "9H-carbazole + H(+) + NADH + O2 => 2'-aminobiphenyl-2,3-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69685", "l": "CHEK2 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202111", "l": "AKT1 phosphorylates eNOS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424476", "l": "Activation of RAC1 by VAV2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38611", "l": "NAD(+) = cyclic ADP-beta-D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26338", "l": "L-homocysteine + S-methyl-L-methionine => H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39736", "l": "3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2168038", "l": "Collagen type XV restin release (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975594", "l": "PLB1 hydrolyses RPALM to atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67298", "l": "(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2 => (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5632677", "l": "PTCH is internalized (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47915", "l": "6-deoxy-6-sulfo-D-gluconate <=> 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57115", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35827", "l": "H2O + N(1)-aminopropylagmatine = spermidine + urea", "d": []}, {"i": "EC:3.5.3.24", "l": "\"N(1)-aminopropylagmatine ureohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53296", "l": "(2E)-decenoyl-CoA + NADP(+) = (2E,4E)-decadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38732", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0016805", "l": "dipeptidase activity", "d": ["Catalysis of the hydrolysis of a dipeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18176", "l": "(R)-octopamine <=> (4-hydroxyphenyl)acetaldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59166", "l": "AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] => ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49687", "l": "H(+) + NADH + O2 + resorcinol <=> benzene-1,2,4-triol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18947", "l": "CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen] => 2-oxoglutarate + L-prolyl-[collagen] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374337", "l": "Apelin receptor binds to apelin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15900", "l": "4-acetamidobutanoate + H2O <=> 4-aminobutanoate + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11387", "l": "(S)-2-hydroxyoctadecanoate + NAD(+) <=> 2-oxooctadecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044692", "l": "exoribonuclease activator activity", "d": ["Binds to and increases the activity of an exoribonuclease."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44297", "l": "2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA => 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67542", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine => (9Z)-hexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66794", "l": "(3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2 => N-methyl-D-dopa + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0008425", "l": "2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13567", "l": "4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+) => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211950", "l": "CYP24A1 24-hydroxylates CTL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869683", "l": "oxPL binds LBP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9670014", "l": "Factor VIIIa dissociates  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853309", "l": "Autocatalytic phosphorylation of FGFR3 fusions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51631", "l": "formate + H(+) + UTP <=> CO2 + dUTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71948", "l": "N-acetyl-L-aspartate(out) + 3 Na(+)(out) => N-acetyl-L-aspartate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191656", "l": "Closure of gap junction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706837", "l": "AR binds AR antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71676", "l": "glycyl-L-leucine(out) + H(+)(out) => glycyl-L-leucine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009282", "l": "CDK1 phosphorylates RUNX2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24519", "l": "acetyl-CoA + gentamicin C1a <=> CoA + H(+) + N(2')-acetylgentamicin C1a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66519", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20914", "l": "diphosphate + taxa-4,11-diene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40334", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP <=> 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237119", "l": "Acireductone is oxidized to MOB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060422", "l": "peptidyl-dipeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866277", "l": "AP-2 directly binds some endocytic cargo (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59095", "l": "[(1->3)-alpha-D-glucosyl](n) + sucrose <=> [(1->3)-alpha-D-glucosyl](n+1) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18148", "l": "ATP + beta-D-fructose <=> ADP + beta-D-fructose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.33", "l": "\"amylo-alpha-1,6-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70246", "l": "an N-acylsphing-4-enine + UDP-alpha-D-xylose <=> a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51221", "l": "1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008597", "l": "calcium-dependent protein serine/threonine phosphatase regulator activity", "d": ["Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase."]}, {"i": "REACT:R-HSA-139906", "l": "Activation of BAD by calcineurin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17155", "l": "CDP-4-dehydro-6-deoxy-D-glucose + H2O => CDP-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56787", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O <=> (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69283", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate <=> 3-hydroxypropyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24728", "l": "H(+) + indolmycin + S-adenosyl-L-homocysteine => N-demethylindolmycin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31254", "l": "(S)-3-hydroxyisobutanoyl-CoA + H2O <=> (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50256", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72584", "l": "(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+) => 3,22-dioxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21250", "l": "diphosphate + RNA(n+1) => a ribonucleoside 5'-triphosphate + RNA(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32778", "l": "(2-aminoethyl)phosphonate(out) + ATP + H2O <=> (2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102904", "l": "germacrene C synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = germacrene C + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34447", "l": "dTDP-6-deoxy-beta-L-talose + NAD(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68595", "l": "ORC2 binds ORC3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60630", "l": "A + H2O + progoitrin => AH2 + gluconapin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40002", "l": "a sphingoid 1-phosphate <=> a fatty aldehyde + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38475", "l": "L-histidine + S-adenosyl-L-methionine = H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9736953", "l": "FURIN translocates to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72228", "l": "chloride(out) + 2 Na(+)(out) + sarcosine(out) => chloride(in) + 2 Na(+)(in) + sarcosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9731924", "l": "EDNRA binds EDNs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52654", "l": "eburicol + H(+) + S-adenosyl-L-homocysteine => lanosterol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102655", "l": "1-18:1-2-trans-16:1-phosphatidylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30223", "l": "2 Fe(III)-[cytochrome c] + hydrogen sulfide = 2 Fe(II)-[cytochrome c] + H(+) + sulfur", "d": []}, {"i": "EC:1.8.2.3", "l": "\"sulfide-cytochrome-c reductase (flavocytochrome c)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73044", "l": "creatine(in) => creatine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68507", "l": "(2Z,6Z)-farnesyl diphosphate <=> (Z)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31130", "l": "3-O-methylgallate + O2 <=> 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47163", "l": "4beta-methylzymosterol-4alpha-carboxylate + NAD(+) <=> 3-dehydro-4-methylzymosterol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38985", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+) => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73722", "l": "3,4-dihydroxybenzoate + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52280", "l": "(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63657", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18215", "l": "CDP-D-glucose + diphosphate => alpha-D-glucose 1-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375138", "l": "CDO binds BOC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43956", "l": "15-methylhexadecanoate + H(+) + NADPH + O2 = H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29397", "l": "diphosphate + H(+) + UMP => H2O + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805811", "l": "Release of SEPT4 from mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418553", "l": "cAMP degradation by Phosphodiesterases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430311", "l": "Rsu-1 interacts with Pinch1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102367", "l": "2-alpha-hydroxytaxusin 7-beta-hydroxylase activity", "d": ["Catalysis of the reaction: 2alpha-hydroxytaxusin + NADPH + O2 + H+ <=> 2alpha, 7beta-dihydroxytaxusin + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047457", "l": "exo-(1,4)-alpha-D-glucan lyase activity", "d": ["Catalysis of the reaction: linear alpha-D-glucan = 1,5-anhydro-D-fructose + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54344", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33450", "l": "4beta-methylzymosterol-4alpha-carboxylate + NADP(+) <=> 3-dehydro-4-methylzymosterol + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389862", "l": "Conversion of glyoxylate to oxalate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050025", "l": "L-glutamate oxidase activity", "d": ["Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61532", "l": "ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10201", "l": "butanoate + NAD(+) => (2E)-2-butenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62232", "l": "a thymidine(6-4)thymidine in DNA = a thymidine dimer in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58513", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28016", "l": "methyl thiocyanate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + thiocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70982", "l": "Fumarate + H2O <=> (S)-Malate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57925", "l": "H2O + mutildienyl diphosphate => diphosphate + premutilin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052850", "l": "NADPH-dependent dihydrocurcumin reductase activity", "d": ["Catalysis of the reaction: dihydrocurcumin + NADPH+ + H+ = tetrahydrocurcumin + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47425", "l": "(2E,9Z)-octadecadienoyl-CoA + H2O => (3S)-hydroxy-(9Z-octadecenoyl)-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928591", "l": "EPH:EFN tetramers oligomerise (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68668", "l": "16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68934", "l": "AMP + diphosphate + NADP(+) + octanal => ATP + H(+) + NADPH + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59141", "l": "ATP + citrate + N(5)-[(S)-citryl]-D-ornithine => AMP + diphosphate + H(+) + staphyloferrin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49653", "l": "H(+) + NADH + O2 + protoviolaceinate => H2O + NAD(+) + violaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15023", "l": "4-O-feruloyl-D-quinate + CoA => (E)-feruloyl-CoA + L-quinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047702", "l": "beta-lysine 5,6-aminomutase activity", "d": ["Catalysis of the reaction: (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60053", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 => a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31853", "l": "parkeol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102692", "l": "benzyladenine UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine <=> H+ + N-benzyl-9-(alpha-D-glucosyl)adenine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55310", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050483", "l": "IMP 5'-nucleotidase activity", "d": ["Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034006", "l": "amorpha-4,11-diene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = amorpha-4,11-diene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018463", "l": "6-hydroxyhexanoate dehydrogenase activity", "d": ["Catalysis of the reaction: 6-hydroxyhexanoate + NAD+ = 6-oxohexanoate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788623", "l": "p-Y-STATs translocate to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56706", "l": "3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate => (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25903", "l": "D-arabino-hex-3-ulose 6-phosphate <=> beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30013", "l": "ADP + beta-D-galactose(in) + H(+) + phosphate => ATP + beta-D-galactose(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17369", "l": "glycyrrhizin + H2O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate", "d": []}, {"i": "EC:3.2.1.128", "l": "\"glycyrrhizinate beta-glucuronidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71931", "l": "fumarate(out) + 3 Na(+)(out) = fumarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63049", "l": "H2O + pravastatin lactone => H(+) + pravastatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58639", "l": "N-(9Z-octadecenoyl)-(2S)-hydroxyglycine <=> (9Z)-octadecenamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46906", "l": "a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417820", "l": "P2Y9 receptor can bind to LPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53975", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69672", "l": "(2S)-naringenin 7-O-beta-D-glucoside + H2O => (2S)-naringenin + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981621", "l": "C3 convertases spontaneously dissociate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46664", "l": "corticosterone + H(+) + NADPH = 5beta-dihydrocorticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870465", "l": "RGGT binds the RAB-binding subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66873", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75661", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate => (11Z,14Z)-eicosadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21089", "l": "2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 => a flavonol + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209566", "l": "TRAF6 is auto-ubiquitinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110244", "l": "Excision of FapyG by OGG1 glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37723", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21007", "l": "(R)-pantolactone + A <=> 2-dehydropantolactone + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34723", "l": "15-methylhexadecasphing-4-enine 1-phosphate + H2O = 15-methylhexadecasphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52112", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47003", "l": "H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791169", "l": "Expression of WFS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36809", "l": "3-oxo-triacontanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + octacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61367", "l": "ATP + dehydroepiandrosterone 3-sulfate(in) + H2O <=> ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25662", "l": "(2E)-geranyl diphosphate = alpha-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30192", "l": "15-cis-phytoene + plastoquinone-9 => 15,9'-di-cis-phytofluene + plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62319", "l": "salicylate + UDP-alpha-D-glucose <=> 1-O-salicyl-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042957", "l": "dextrin transmembrane transporter activity", "d": ["Enables the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004392", "l": "heme oxygenase (decyclizing) activity", "d": ["Catalysis of the reaction: heme b + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = biliverdin + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9736953", "l": "FURIN translocates to the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818682", "l": "MEN1 binds MLL2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70493", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+) => GDP-beta-L-fucose + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031957", "l": "very long-chain fatty acid-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + a very-long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a fatty acid which has a chain length greater than C22."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162657", "l": "Inactivation of Myt1 kinase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51847", "l": "(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788623", "l": "p-Y-STATs translocate to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17892", "l": "H2O + phosphoethanolamine <=> acetaldehyde + NH4(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56231", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31050", "l": "(S)-methylmalonate semialdehyde + CoA + NAD(+) <=> CO2 + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448678", "l": "CTSG cleaves CASP1(1-404) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9728150", "l": "SLC5A2 binds gliflozins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901338", "l": "catecholamine binding", "d": ["Binding to catecholamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18739", "l": "AMP + 2 H(+) + phosphate + selenophosphate => ATP + H2O + hydrogenselenide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20629", "l": "H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726580", "l": "PGR binds PGR agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38562", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate <=> (R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77612", "l": "Formation of dsRNA structure by looping  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-166220", "l": "FA anion diffuses laterally to UCP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75361", "l": "2-aminoprop-2-enoate + 3-hydroxy-4H-pyrid-4-one => L-mimosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57660", "l": "(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15630", "l": "a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] => an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961915", "l": "CDC45 gene expression is stimulated by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-912734", "l": "CBL:CRKL binds RAPGEF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445705", "l": "Release Of ADP From Myosin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174119", "l": "Free APC/C phosphorylated by Plk1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63417", "l": "2,6-dichlorohydroquinone + FADH2 + O2 => 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52725", "l": "3'-phosphoadenylyl sulfate + an aliphatic (Z)-desulfo-glucosinolate => a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381644", "l": "ER calcium channels open in response to activated PKA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38951", "l": "ATP + H2O + sphing-4-enine 1-phosphate(in) = ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625424", "l": "The retrograde IFT train dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22254", "l": "globoside Gb4Cer (d18:1(4E)) + H(+) + UDP => globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428752", "l": "Dissociation of the TP:Gq complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33206", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62907", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004639", "l": "phosphoribosylaminoimidazolesuccinocarboxamide synthase activity", "d": ["Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69586", "l": "guanosine + IMP => GMP + inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733495", "l": "Viral Spike Binds to ACE2 on Uninfected Cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40815", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16775", "l": "ganglioside GM1 (d18:1(4E)) + H(+) + UDP => ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25978", "l": "(5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58315", "l": "25-substituted-cholesteryl beta-D-glucoside + H2O <=> 25-substituted-cholesterol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428273", "l": "SPHK1 phosphorylates SPG to S1P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.14", "l": "\"asparagine--oxo-acid transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416516", "l": "GRK2 sequesters activated Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11479", "l": "glycerol 1-phosphate + H2O <=> glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13476", "l": "H2O + L-tryptophan + NAD(+) <=> H(+) + indole-3-pyruvate + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51239", "l": "GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62717", "l": "stemphyloxin I => stemphyloxin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72185", "l": "mRNA polyadenylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247922", "l": "GGCT transforms gGluCys to OPRO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33318", "l": "a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68804", "l": "H2O + kojibiose = alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56078", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170991", "l": "SRC-1 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57119", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41938", "l": "a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340226", "l": "CYGB dioxygenates NO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21308", "l": "(S)-2,3-epoxysqualene = cycloartenol", "d": []}, {"i": "EC:5.4.99.8", "l": "\"cycloartenol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448744", "l": "IL20RA binds IL20RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1307802", "l": "MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-179410", "l": "Association of Nek2A with MCC:APC/C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9763137", "l": "BRCA2 binds SEM1 (DSS1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428625", "l": "Vesicular inhibitory amino acid transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626699", "l": "MARK4 binds ODF2 in the centriole (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9651280", "l": "RAS GAP mutants aren't stimulated by GAPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35478", "l": "(1'S,5'S)-5'-hydroxyaverantin + NAD(+) <=> (S)-5'-oxoaverantin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59078", "l": "2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+) => bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12358", "l": "D-fructose 6-phosphate => D-mannose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5632738", "l": "DDIT4 binds 14-3-3 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24930", "l": "H2O + L-cystine <=> NH4(+) + pyruvate + S-sulfanyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41327", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611751", "l": "β1,2-agonists bind ADRB1,2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40379", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19850", "l": "H2O + NADP(+) => ADP-D-ribose 2'-phosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75990", "l": "a dicarboxylate(in) + indoxyl sulfate(out) <=> a dicarboxylate(out) + indoxyl sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14142", "l": "AMP + glutathione disulfide + 2 H(+) + sulfite => adenosine 5'-phosphosulfate + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944247", "l": "Association of procollagen type VI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888589", "l": "Release of GABA at the synapse (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52163", "l": "(E)-phenylacetaldehyde oxime <=> (Z)-phenylacetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191299", "l": "Squalene is oxidized to its epoxide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804652", "l": "UACA binds apoptosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41615", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O <=> D-ribose 2,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15206", "l": "a dolichyl diphosphooligosaccharide + H2O => a dolichyl phosphate + an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071111", "l": "cyclic-guanylate-specific phosphodiesterase activity", "d": ["Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40729", "l": "a 1-acylglycerone 3-phosphate + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102162", "l": "all-trans-8'-apo-beta-carotenal 15,15'-oxygenase activity", "d": ["Catalysis of the reaction: 8'-apo-beta,psi-caroten-8'-al + O2 <=> all-trans-retinal + 2,6-dimethylocta-2,4,6-trienedial."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44253", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0019103", "l": "pyrimidine nucleotide binding", "d": ["Binding to a pyrimidine nucleotide, a pyrimidine nucleoside esterified with (ortho)phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799246", "l": "CHEK1 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59382", "l": "3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH => 4-amino-4-deoxyprephenate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9675026", "l": "Formation of the MLL1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381158", "l": "ATF6:HSPA5 (ATF6-alpha:BiP) dissociates and HSPA5 binds unfolded protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41968", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004923", "l": "leukemia inhibitory factor receptor activity", "d": ["Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23996", "l": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082391", "l": "Trimerization of HSF1 in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23631", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51501", "l": "ATP + N-acetyl-D-muramate => ADP + H(+) + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028525", "l": "NR1H2 or NR1H3, NRIP1 bind the SREBF1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40996", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA => 4-hydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561072", "l": "OCT3 mediates renal uptake of organic cations (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15969", "l": "2 glutathione + H(+) + methylarsonate = glutathione disulfide + H2O + methylarsonous acid", "d": []}, {"i": "EC:1.20.4.2", "l": "\"methylarsonate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39198", "l": "3-oxotetracosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxytetracosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264435", "l": "Dissociation of the COP1-p53 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24671", "l": "H2O + hypoxanthine + NAD(+) => H(+) + NADH + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682011", "l": "LC3 binds ATG7 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50967", "l": "cytidine(8) in tRNA + H(+) + H2O <=> NH4(+) + uridine(8) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625510", "l": "FOXO1 and p-2S-SMAD2/3:SMAD4 bind MSTN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005360", "l": "insulin-responsive glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65905", "l": "3-hydroxy-L-kynurenine + glyoxylate => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53166", "l": "a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16825", "l": "ATP + uridine = ADP + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18301", "l": "ATP + NH4(+) + XMP = AMP + diphosphate + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15305", "l": "betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.8", "l": "\"betaine-aldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381668", "l": "cAMP activates EPAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73523", "l": "TTP(out) + UTP(in) = TTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662608", "l": "MT2A binds cadmium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0052842", "l": "inositol diphosphate pentakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55394", "l": "an N(1)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57470", "l": "1-O-[(E)-feruloyl]-beta-D-glucose + UDP => (E)-ferulate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36113", "l": "O-methyl gibberellin A1 + S-adenosyl-L-homocysteine => gibberellin A1 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36427", "l": "2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59104", "l": "a dolichyl beta-D-glucosyl phosphate + chenodeoxycholate = a dolichyl phosphate + beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63618", "l": "H(+) + prunetin-C(8)-beta-D-glucuronide + UDP => prunetin + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62879", "l": "AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate <=> A + semiviriditoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296309", "l": "HCAR3 binds HCAR3 ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008728", "l": "GTP diphosphokinase activity", "d": ["Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57954", "l": "catechol + H2O + NAD(+) => H(+) + NADH + O2 + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33978", "l": "DIMBOA beta-D-glucoside + H2O <=> D-glucose + DIMBOA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734475", "l": "PPARA binds fibrates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74452", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983422", "l": "Disassembly of COPII coated vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983158", "l": "Trimming of peptides in ER (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604360", "l": "Initial activation of proMMP2 by MMP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237119", "l": "Acireductone is oxidized to MOB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71963", "l": "(R)-2-hydroxyglutarate(out) + 3 Na(+)(out) = (R)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37792", "l": "aclacinomycin A + O2 => aclacinomycin Y + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9017797", "l": "NOTCH3 binds YBX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25015", "l": "(E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.98.4", "l": "\"5a,11a-dehydrotetracycline reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51727", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate <=> adenosine 5'-tetraphosphate + ADP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42109", "l": "(20S)-hydroxypregn-4-en-3-one + NAD(+) => H(+) + NADH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9757256", "l": "MCM3 binds MCM5 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.72", "l": "\"glycerol dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806957", "l": "MET receptor dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647632", "l": "CASP3 cleaves GSDME (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660013", "l": "Defective RPIA does not isomerize RU5P to R5P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11625", "l": "2-(hydroxyimino)propanoate + acetone => acetone oxime + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428287", "l": "IGF2BP3 binds specific RNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46695", "l": "4-hydroxybenzoate + ATP + H(+) <=> 4-hydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5221061", "l": "TDG excises 5-carboxylcytosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.221", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27477", "l": "2-oxoglutarate + O2 + thebaine = CO2 + formaldehyde + neopinone + succinate", "d": []}, {"i": "EC:1.14.11.31", "l": "\"thebaine 6-O-demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69863", "l": "a uridine in mRNA + S-adenosyl-L-methionine = a 5-methyluridine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33747", "l": "a 1-acyl-sn-glycerol + ATP = a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38328", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44401", "l": "3-demethylubiquinol-6 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17205", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate", "d": []}, {"i": "EC:2.8.2.27", "l": "\"quercetin-3-sulfate 4'-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38991", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654425", "l": "Activated FGFR4 binds SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425861", "l": "Activation of Protein Kinase C novel isoforms (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3209165", "l": "ID1 sequesters ETS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16422", "l": "an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849463", "l": "PTK6 phosphorylates SFPQ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48183", "l": "H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.204", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11695", "l": "NAD(+) + NADPH <=> NADH + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65178", "l": "AH2 + protoaustinoid B => A + protoaustinoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53336", "l": "5,6-dihydrouridine(20) in tRNA + NADP(+) = H(+) + NADPH + uridine(20) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247836", "l": "Retromer recycles WLS to the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-982810", "l": "JAK2 phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75238", "l": "TRAIL binds TRAIL receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64670", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205289", "l": "Autophosphorylation of KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102681", "l": "isoamylase (maltodextrin-releasing) activity", "d": ["Catalysis of the reaction: n H2O + a glycogen <=> n a maltodextrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19217", "l": "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)", "d": []}, {"i": "EC:4.5.1.1", "l": "\"DDT-dehydrochlorinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114683", "l": "Phosphorylation of Platelet Sec-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033446", "l": "AGC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AGC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22969", "l": "butanal + CoA + NAD(+) => butanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12167", "l": "3'-phosphoadenylyl sulfate + a phenol <=> adenosine 3',5'-bisphosphate + an aryl sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54724", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433815", "l": "viral dsRNA : TRL3 recruits TICAM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49026", "l": "2-iminio-3-(indol-3-yl)propanoate + H2O2 => L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10947", "l": "H2O + psi-UMP <=> phosphate + pseudouridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55416", "l": "biochanin A + UDP-alpha-D-glucose = biochanin A 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166214", "l": "FA anion flip-flops to the opposite surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936000", "l": "RUNX1 binds the CLDN5 (Claudin-5) gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086056", "l": "voltage-gated calcium channel activity involved in AV node cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23416", "l": "(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate", "d": []}, {"i": "EC:3.1.3.71", "l": "\"2-phosphosulfolactate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358790", "l": "RNF41 ubiquitinates ERBB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61820", "l": "3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose = epiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33400", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) => L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55154", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein] => H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473594", "l": "Collagen type II degradation by MMP15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203613", "l": "depalmitoylation of eNOS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63371", "l": "ATP + H2O + spermine(out) <=> ADP + H(+) + phosphate + spermine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730862", "l": "Autophosphorylation of LYN kinase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0051381", "l": "histamine binding", "d": ["Binding to histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19424", "l": "(R)-2-hydroxypropyl-coenzyme M <=> (R)-1,2-epoxypropane + coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64506", "l": "2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine => AH2 + H(+) + 3 malonyl-CoA + propanoyl-CoA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982617", "l": "CYGB:O2 dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46203", "l": "5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762333", "l": "ANGPTL4 binds to CDH11v (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51194", "l": "2-oxoglutarate + H(+) + NADPH => (R)-2-hydroxyglutarate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167637", "l": "Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61116", "l": "(2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1801587", "l": "Expression of CPT1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30365", "l": "(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate => fumonisin B1 + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67674", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphate => a 1,2-diacyl-sn-glycero-3-phosphate + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20341", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.96", "l": "\"sn-glycerol-3-phosphate 1-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22910", "l": "3',5'-cyclic IMP + NH4(+) => 3',5'-cyclic AMP + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30947", "l": "(2E,6E)-farnesyl diphosphate + H2O = 10-epi-gamma-eudesmol + diphosphate", "d": []}, {"i": "EC:4.2.3.84", "l": "\"10-epi-gamma-eudesmol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34212", "l": "ecgonine methyl ester + NADP(+) => ecgonone methyl ester + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653957", "l": "Rag dimer formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27551", "l": "(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate", "d": []}, {"i": "EC:2.5.1.31", "l": "\"ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22835", "l": "H2O + N-formimidoyl-L-glutamate <=> N-formyl-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44480", "l": "3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106340", "l": "tRNA (guanosine 34-2'-O)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine 34 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylguanosine 34 in tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592242", "l": "Expression of NRF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72575", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O = (22R)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9623384", "l": "α1-agonists bind ADRA1A,B,D (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44923", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH <=> (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36670", "l": "(15Z)-tetracosenoyl-CoA + sphinganine <=> CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216043", "l": "Collagen type II binds integrin alpha10beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682388", "l": "Autophagosome maturation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034849", "l": "2-naphthoate CoA-transferase activity", "d": ["Catalysis of the reaction: 2-naphthoyl-CoA + OH- = 2-naphthoate + CoASH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22851", "l": "(3S)-hydroxyoctanedioyl-CoA + NAD(+) <=> 3-oxooctanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799761", "l": "TP53 binds PPP1R13L (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15074", "l": "3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O => D-glucuronate + N(2),6-disulfo-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850534", "l": "PDCL promotes G-protein beta 5 folding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430135", "l": "p-SLP-76 binds ADAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14105", "l": "L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54459", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38267", "l": "2-methylfumaryl-CoA = 3-methylfumaryl-CoA", "d": []}, {"i": "EC:5.4.1.3", "l": "\"2-methylfumaryl-CoA isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635859", "l": "GLI:SUFU dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850794", "l": "SPINK6 binds KLK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174967", "l": "NAT2 acetylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952996", "l": "E2F7 forms homodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098623", "l": "selenite reductase activity", "d": ["Catalysis of the reaction: SeO3(2-) + 3NADPH + 5H+ = H2Se + 3NADP+ + 3H2O."]}, {"i": "REACT:R-HSA-2408558", "l": "SeO3(2-) is reduced to H2Se by TXNRD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63227", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 <=> 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45303", "l": "an N-(acyl)-sphingosylphosphocholine + H2O <=> an N-acyl-sphingoid base + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634228", "l": "TRAF1 is cleaved by caspases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5227009", "l": "ABCF1 binds EIF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51270", "l": "4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine => norbelladine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247836", "l": "Retromer recycles WLS to the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37946", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69282", "l": "3-hydroxypropyl isothiocyanate + sulfate => (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33012", "l": "(+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] => (+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20747", "l": "NADP(+) + prostaglandin D2 <=> 15-oxoprostaglandin D2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008054", "l": "IL1F10 binds IL1RAPL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626928", "l": "CREBBP binds FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11431", "l": "beta-D-glucose + O2 <=> D-glucono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30694", "l": "H2O2 + methanol <=> formaldehyde + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25539", "l": "ent-copalyl diphosphate <=> diphosphate + ent-sandaracopimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418662", "l": "Src activation following P2Y purinoceptor activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29335", "l": "H2O + L-alanyl-L-glutamate = L-alanine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102143", "l": "carboxynorspermidine dehydrogenase I activity", "d": ["Catalysis of the reaction: carboxynorspermidine + NADP + H2O <=> L-aspartic acid 4-semialdehyde betaine + trimethylenediaminium + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38903", "l": "a sphingomyelin(in) + ATP + H2O = a sphingomyelin(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4411373", "l": "NLK translocates to nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.3", "l": "\"triacylglycerol lipase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70429", "l": "2-phenylacetate + CoA + H(+) => H2O + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218824", "l": "p-6Y-VEGFR2 binds FYN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034894", "l": "4-hydroxypyridine-3-hydroxylase activity", "d": ["Catalysis of the reaction: 4-hydroxypyridine + O2 + H+ + NADPH = pyridine-3,4-diol + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866304", "l": "pre-VLDL binds lipids to form VLDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420202", "l": "Secretin receptor binds secretin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29750", "l": "3-phenylpropanoate(in) <=> 3-phenylpropanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56697", "l": "D-ribulose 5-phosphate + L-tryptophan => (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114684", "l": "Phosphorylation of Syntaxin-4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50381", "l": "3 H(+) + 3 malonyl-CoA => 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58357", "l": "2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2 => CO2 + formaldehyde + L-arginyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44220", "l": "15-hydroxypentadecanoate + ATP + CoA = 15-hydroxypentadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58816", "l": "ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate", "d": []}, {"i": "EC:6.3.2.53", "l": "\"UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114552", "l": "Thrombin-activated PARs activate G12/13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48741", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11702", "l": "H2O + NADP(+) + testosterone acetate => H(+) + NADPH + O2 + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433488", "l": "Phosphorylation of SHP2 by SFKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13523", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate => (R)-lactate + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416698", "l": "SEMA5A binds to PLXNB3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70378", "l": "3-oxosphinganine + dodecanoyl-CoA <=> CoA + H(+) + N-dodecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71682", "l": "H(+)(out) + L-lysyl-glycine(out) <=> H(+)(in) + L-lysyl-glycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65041", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + a tri-(9Z,12Z-octadecadienoyl)-monolysocardiolipin => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40879", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-933533", "l": "Dimerization of p-IRF7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709883", "l": "BIL:ALB scavenges O2.- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22677", "l": "chlorophyllide a + H(+) + NADPH + O2 => 7(1)-hydroxychlorophyllide a + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25992", "l": "(2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate", "d": []}, {"i": "EC:4.2.3.37", "l": "\"epi-isozizaene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192746", "l": "Binding of M1 to vRNP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63492", "l": "H(+) + menadione + NADPH = menadiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60106", "l": "(E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein] => H(+) + indole-3-propanoate + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35858", "l": "1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62481", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O => 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40184", "l": "O2 + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45261", "l": "tetracosanoate(out) => tetracosanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49227", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5138432", "l": "DVL2 is phosphorylated by PKC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375384", "l": "Bombesin-like receptors bind bombesin homologues (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296043", "l": "Activation of HCN channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2468040", "l": "Cohesin binds PDS5 and WAPAL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004176", "l": "ATP-dependent peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis."]}, {"i": "REACT:R-HSA-9698929", "l": "pPR-AP:pAP cleaves the MCP:pPR-AP:pAP Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102160", "l": "cyanidin-3-O-glucoside 2-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-glucuronate <=> H+ + cyanidin 3-O-beta-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390649", "l": "CHRM1,3,5 bind acetylcholine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199093", "l": "CXADR binds to AMICA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674093", "l": "PDGFRs bind type I TKI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31804", "l": "H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose => 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16712", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49242", "l": "L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in) => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52301", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445064", "l": "Activation of Rac1 by VAV2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47825", "l": "H(+) + malonyl-[ACP] + octadecanoyl-[ACP] => 3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-879459", "l": "F-actin capping protein is a heterodimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46328", "l": "L-threo-3-phenylserine = 3-phenylpyruvate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22549", "l": "H2O + L-lysine + O2 => (S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31757", "l": "3-oxo-5,6-dehydrosuberyl-CoA semialdehyde => 2-oxepin-2(3H)-ylideneacetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43652", "l": "decanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032562", "l": "dAMP binding", "d": ["Binding to dAMP, deoxyadenosine monophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47453", "l": "(2E,5Z)-tetradecadienoyl-CoA + H2O => (3S)-hydroxy-(5Z-tetradecenoyl)-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36956", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA => (9Z)-pentadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55682", "l": "anthranilate + H(+) + pyruvate => (2S)-2-amino-4-deoxychorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68845", "l": "(2Z,6E)-farnesyl diphosphate => (Z)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64875", "l": "D-ribulose 1-phosphate <=> dihydroxyacetone phosphate + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75625", "l": "14-oxo-15-hydroxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67530", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(6Z-octenoyl)-4'-phosphopantetheine => (6Z)-octenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680349", "l": "CSF1R dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41217", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43463", "l": "dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31311", "l": "(2R)-3-phosphoglycerate + ADP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21052", "l": "(S)-2-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.269", "l": "\"2-(S)-hydroxypropyl-CoM dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45455", "l": "H2O + N-tetradecanoylethanolamine <=> ethanolamine + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52492", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12730", "l": "lutein => (3R,3'S)-zeaxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033813", "l": "deacetylcephalosporin-C acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754191", "l": "LEF1 or TCF7 (TCF1), CTNNB1, and TBPL2 (TRF3) bind the TBXT (T, Brachyury) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850997", "l": "TRIM27 binds PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66109", "l": "2-oxobutanoate + L-cysteine => (2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139898", "l": "Caspase-8 activates BID by cleavage (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74715", "l": "Autophosphorylation of insulin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60139", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 <=> a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75146", "l": "prosolanapyrone III <=> solanapyrone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65533", "l": "2-methylbutan-1-ol + hexanoyl-CoA => 2-methylbutyl hexanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55547", "l": "L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1218833", "l": "Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5333678", "l": "CPNEs bind PL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35000", "l": "ADP(in) + ATP(out) => ADP(out) + ATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55469", "l": "11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] => 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22591", "l": "4-aminobutanal <=> 1-pyrroline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72976", "l": "2 ATP + 2 indole-3-pyruvate => 2 AMP + didemethylasterriquinone D + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209828", "l": "Tryptophan is hydroxylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16437", "l": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22240", "l": "H2O + methylenediurea = N-(carboxyaminomethyl)urea + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701507", "l": "PTPN6 dephosphorylates JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955706", "l": "TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033755", "l": "sulfur oxygenase/reductase activity", "d": ["Catalysis of the reaction: 4 sulfur + 4 H2O + O2 = 2 hydrogen sulfide + 2 bisulfite + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177942", "l": "EGFR binds EGF ligand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692408", "l": "NPR2 binds NPPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032532", "l": "NTRK2-bound FYN autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944225", "l": "Association of procollagen type XVII (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55491", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68406", "l": "2-oxoheptanedioate + CO2 + NADH => (2R,3S)-iso(homo)2citrate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10531", "l": "dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57165", "l": "2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 => (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10837", "l": "NADPH + O2 + questin => demethylsulochrin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374298", "l": "Opioid receptors bind opioid peptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373747", "l": "Phosphorylation of nephrin by FYN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68803", "l": "H2O + nigerose <=> alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64945", "l": "dCTP + 2 H2O => dCMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58091", "l": "1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O <=> (7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48580", "l": "[pyruvate, water dikinase]-phosphate + H(+) + phosphate = [pyruvate, water dikinase] + diphosphate", "d": []}, {"i": "EC:2.7.4.28", "l": "\"([Pyruvate, water dikinase] phosphate) phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50037", "l": "choloyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68330", "l": "(R)-pantetheine + phosphate => (R)-4'-phosphopantetheine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19466", "l": "NADPH + 2 nitric oxide + 2 O2 => H(+) + NADP(+) + 2 nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1028820", "l": "Formation of VAF (virus-activated factor) complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27564", "l": "(2E)-geranyl diphosphate + 7 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 7 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018794", "l": "RHOV binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703433", "l": "Ligand-independent dimerization of FLT3 fusion proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29176", "l": "2 O2 + ubiquinol-8 => 2 H(+) + 2 superoxide + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.84", "l": "\"glucan 1,3-alpha-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28875", "l": "H(+)(in) + L-tyrosine(in) = H(+)(out) + L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27904", "l": "1,3,7-trimethylurate + ubiquinol-0 => caffeine + H2O + ubiquinone-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34771", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) = a 3-oxosteroid + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26546", "l": "beta-alaninamide + H2O = beta-alanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66443", "l": "butan-2-one + NADP(+) <=> but-3-en-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76057", "l": "H(+) + reticuline + S-adenosyl-L-homocysteine => norreticuline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18459", "l": "(2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+) => D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13184", "l": "ATP + H2O + nitrate(out) <=> ADP + H(+) + nitrate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047959", "l": "glycine dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: glycine + H2O + 2 ferricytochrome c = glyoxylate + NH3 + 2 ferrocytochrome c."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791096", "l": "Expression of PPP2R5B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35909", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA => 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856398", "l": "NPTN binds GABA A receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3315483", "l": "Phosphorylated SMAD2/3 MH2 Domain Mutants do not bind SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29995", "l": "ATP + H2O + putrescine(out) = ADP + H(+) + phosphate + putrescine(in)", "d": []}, {"i": "EC:7.6.2.16", "l": "\"ABC-type putrescine transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.118", "l": "\"kallikrein 8\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696183", "l": "AOC3 deaminates BZAM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38398", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O <=> (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72214", "l": "(+)-isoborneol + NAD(+) <=> (1S,4S)-camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34784", "l": "a 3alpha-hydroxysteroid + NADP(+) => a 3-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693783", "l": "NAALADases hydrolyse NAAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40301", "l": "erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12591", "l": "ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GM2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877153", "l": "STARD7 binds PC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56408", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045030", "l": "G protein-coupled UTP receptor activity", "d": ["Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50957", "l": "cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205321", "l": "Interaction of KIT and sSCF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6795473", "l": "PDPK1 phosphorylates SGK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11914", "l": "15-oxoprostaglandin E2 + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64803", "l": "NAD(+) + S-(2-aminoethyl)-L-cysteine <=> (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57712", "l": "(E)-sinapaldehyde + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.51", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10322", "l": "1-pyrroline-2-carboxylate + H2O => trans-3-hydroxy-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018517", "l": "phthalate 4,5-cis-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD+ = 4,5-dihydroxyphthalate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53879", "l": "a cytidine in tRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21393", "l": "2-phenylacetaldehyde + H2O + NAD(+) => 2-phenylacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814409", "l": "CK2 phosphorylates PDCL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33744", "l": "an N-acylsphing-4-enine 1-phosphate + H2O => an N-acylsphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33364", "l": "D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] => D-mannitol 1-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008658", "l": "penicillin binding", "d": ["Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.3", "l": "\"lysine carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52235", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + Fe(2+) + 3 H2O + mycobilin a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33219", "l": "ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.107", "l": "\"ent-kaurenoic acid monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32023", "l": "(2E,6E)-farnesyl diphosphate + H2O = avermitilol + diphosphate", "d": []}, {"i": "EC:4.2.3.96", "l": "\"avermitilol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60388", "l": "Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45976", "l": "3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11454", "l": "H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690785", "l": "BAP1 binds Ub-HCFC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61609", "l": "[DsbB protein]-dithiol + a quinone => [DsbB protein]-disulfide + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9761474", "l": "AMOT-2 binds CDH11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65497", "l": "3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH => 3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35434", "l": "1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside <=> cyanidin 3,7-di-O-beta-D-glucoside + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72797", "l": "bilirubin-bisglucuronoside(in) => bilirubin-bisglucuronoside(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033907", "l": "beta-D-fucosidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing beta-D-fucose residues in beta-D-fucosides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14437", "l": "H2O + L-lysine + O2 = 6-amino-2-oxohexanoate + H2O2 + NH4(+)", "d": []}, {"i": "EC:1.4.3.14", "l": "\"L-lysine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187506", "l": "Translocation of p27 to the nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22186", "l": "acenaphthene-1,2-dione + 2 H(+) + 2 NADPH => (+-)-trans-acenaphthene-1,2-diol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9737780", "l": "MTTP binds lomitapide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848339", "l": "PNPLA5 hydrolyzes TAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16459", "l": "2-hydroxy-3-oxosuccinate + H(+) + NADH => (2R,3S)-tartrate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43799", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12320", "l": "17-O-acetylnorajmaline + NADP(+) = 1,2-dihydrovomilenine + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.73", "l": "\"1,2-dihydrovomilenine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58505", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate => (3Z)-2-oxo-4-carboxy-3-hexenedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43421", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP => 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57417", "l": "H2O + L-asparaginyl-[protein] => L-aspartyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696564", "l": "USP25 deubiquitinates DDX58 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21433", "l": "(S)-malate + NAD(+) => H(+) + NADH + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050057", "l": "linamarin synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018810", "l": "trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity", "d": ["Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38983", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65726", "l": "CO2 + H(+) + pentanal + succinate + sulfate => 2-oxoglutarate + O2 + pentyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389978", "l": "alpha-tubulin:GTP + Cofactor E ->  alpha-tubulin:GTP:Cofactor E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805399", "l": "TAF1 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031863", "l": "prostaglandin D2 receptor binding", "d": ["Binding to a prostaglandin D2 receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030772", "l": "tryptophan 2-C-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9656891", "l": "OPN1SW binds 11cRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181152", "l": "Cleavage of NODAL proprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71755", "l": "2-oxoglutarate(out) + 2-oxoheptanedioate(in) = 2-oxoglutarate(in) + 2-oxoheptanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66645", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + trichobrasilenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253321", "l": "GFAP gene expression is inhibited by ERBB4:TAB2:NCOR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.48", "l": "\"sucrose alpha-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54972", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428749", "l": "Activated TP receptor binds G-proten Gq (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71316", "l": "chloride(out) + L-serine(out) + 2 Na(+)(out) => chloride(in) + L-serine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61391", "l": "ATP + biotin(in) + H2O <=> ADP + biotin(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800794", "l": "PIDD1 associates with CRADD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689317", "l": "Formation of the pre-incision complex in GG-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52423", "l": "O-phospho-L-serine + thiosulfate <=> phosphate + S-sulfo-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19255", "l": "an N-acylsphing-4-enine + H(+) + phosphocholine => a sphingomyelin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944250", "l": "Association of procollagen type XXV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051908", "l": "double-stranded DNA 5'-3' exodeoxyribonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005545", "l": "1-phosphatidylinositol binding", "d": ["Binding to a phosphatidylinositol, a glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2545203", "l": "Deacetylation of cleaved cohesin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350598", "l": "Arginine<=>Agmatine+CO2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004355", "l": "glutamate synthase (NADPH) activity", "d": ["Catalysis of the reaction: 2 L-glutamate + NADP+ = 2-oxoglutarate + L-glutamine + H+ + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814132", "l": "GDPD5 hydrolyzes GPCho (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198314", "l": "DAG stimulates protein kinase C-delta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36840", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62400", "l": "(1R,2S)-ephedrine + NAD(+) = (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56784", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate", "d": []}, {"i": "EC:3.4.19.9", "l": "\"folate gamma-glutamyl hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54297", "l": "GTP + L-tyrosyl-[protein] => diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016230", "l": "sphingomyelin phosphodiesterase activator activity", "d": ["Binds to and increases the activity of the enzyme sphingomyelin phosphodiesterase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10403", "l": "L-glutamine + pyruvate <=> 2-oxoglutaramate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15901", "l": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49284", "l": "8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP = CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate", "d": []}, {"i": "EC:2.7.7.90", "l": "\"8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56979", "l": "4-methylphenol + H2O + 2 oxidized [azurin] <=> 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905502", "l": "acetyl-CoA binding", "d": ["Binding to acetyl-CoA, an acyl-CoA having acetyl as its S-acetyl component."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000269", "l": "toxin export channel activity", "d": ["Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74994", "l": "deoxyerythrostominone(in) <=> deoxyerythrostominone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047422", "l": "N-acyl-D-aspartate deacylase activity", "d": ["Catalysis of the reaction: N-acyl-D-aspartate + H2O = D-aspartate + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31431", "l": "(2E,6E)-farnesyl diphosphate = (-)-beta-santalene + diphosphate", "d": []}, {"i": "EC:4.2.3.83", "l": "\"beta-santalene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204798", "l": "Interaction of Tie2 and p85 of PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-380930", "l": "Phosphorylated AMPK binds AMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.13", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) (phosphorylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38694", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57824", "l": "dAMP + H2O = 2-deoxy-D-ribose 5-phosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:1902121", "l": "lithocholic acid binding", "d": ["Binding to lithocholic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48861", "l": "18-HEPE + O2 => (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30917", "l": "a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31980", "l": "NADPH + O2 + trimethylamine => H2O + NADP(+) + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34118", "l": "carboxynorspermidine + H2O + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034450", "l": "ubiquitin-ubiquitin ligase activity", "d": ["Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417820", "l": "P2Y9 receptor can bind to LPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23227", "l": "trans-zeatin + UDP-alpha-D-glucose <=> H(+) + O-beta-D-glucosyl-trans-zeatin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50695", "l": "ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate <=> ADP + alpha-maltose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73351", "l": "ATP + beta-alanine + histamine = AMP + carcinine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2197691", "l": "WIP binds WASP,N-WASP, activating them (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54973", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46311", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33389", "l": "aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine => cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16910", "l": "2 Fe(III)-[cytochrome c] + glycine + H2O => 2 Fe(II)-[cytochrome c] + glyoxylate + 2 H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64212", "l": "an N-(fatty acyl)-L-isoleucine + H2O = a fatty acid + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26493", "l": "a secondary nitroalkane + H2O + O2 <=> a ketone + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19160", "l": "D-xylonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9771686", "l": "nsp12 acquires Fe-S cluster cofactors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45816", "l": "(S)-lactate + A = AH2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73627", "l": "CTP(out) + GMP(in) = CTP(in) + GMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797974", "l": "LRRTMs bind NRXNs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941895", "l": "Formation of CDK4/6:CCND complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56291", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453337", "l": "glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75897", "l": "CoA + thiomarinol C => holothin + marinoloyl-CoA C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43733", "l": "a triacyl-sn-glycerol + H2O => 1,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357483", "l": "RAC1 binds PAK1-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35016", "l": "riboflavin(in) => riboflavin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10475", "l": "(2R,3S)-2,3-dimethylmalate <=> propanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869549", "l": "TFPA2A homodimer and NPM1 bind the MYBL2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57183", "l": "L-lysyl-[protein] + methylglyoxal <=> N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67937", "l": "a 2-hydroxy carboxylate + O2 => a 2-oxocarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028812", "l": "Expression of interferon-beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212642", "l": "L-Glutamine transport into neurons (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912727", "l": "CBL binds VAV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624798", "l": "LBR binds KPNB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033441", "l": "AAU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AAU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59001", "l": "H2O + O2 + propanal => H(+) + H2O2 + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47901", "l": "ganglioside GM3 (d18:1(4E)) + H2O => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.706056554619465", "identifiers": [{"i": "GO:0016801", "l": "hydrolase activity, acting on ether bonds", "d": ["Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively."]}, {"i": "EC:3.3.-.-", "l": "\"Acting on ether bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52328", "l": "L-arginine + O2 + reduced [flavodoxin] = H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173723", "l": "C8 binds C5b:C6:C7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000833", "l": "inositol heptakisphosphate 4-kinase activity", "d": ["Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983421", "l": "Journey of cargo through Golgi complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944250", "l": "Association of procollagen type XXV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019980", "l": "interleukin-5 binding", "d": ["Binding to interleukin-5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69839", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22S)-22-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17132", "l": "ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11250", "l": "(R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+) => [(3R)-hydroxybutanoate](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483174", "l": "PE is methylated to PC by PEMT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13072", "l": "ATP + ethanolamine <=> ADP + H(+) + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41242", "l": "N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2 <=> N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55099", "l": "(3S)-3-hydroxypentanoyl-CoA + H2O <=> (3S)-3-hydroxypentanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63288", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382054", "l": "PDGF binds to extracellular matrix proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.-", "l": "\"Nucleotidyltransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21972", "l": "precorrin-1 + S-adenosyl-L-methionine = precorrin-2 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57860", "l": "(E)-6-hydroxyferuloyl-CoA = CoA + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28691", "l": "(S)-dihydroorotate + a ubiquinone = a ubiquinol + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.4", "l": "\"fructokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371353", "l": "Soluble TNF-α binds TNFR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33480", "l": "an acyl-CoA + lanosterol => CoA + lanosteryl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050210", "l": "prenyl-diphosphatase activity", "d": ["Catalysis of the reaction: prenyl diphosphate + H2O = prenol + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14058", "l": "a 1,2-diacyl-sn-glycerol + a glycerophospholipid => a monoacylglycerophospholipid + a triacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68603", "l": "ORC5 binds ORC2:ORC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005112", "l": "Notch binding", "d": ["Binding to a Notch (N) protein, a surface receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9726949", "l": "PTGIR binds PTGIR agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912627", "l": "CBL ubiquitinates PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57272", "l": "a 2'-deoxyguanosine in DNA + methylglyoxal = an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4331324", "l": "E2F1 binds BBC3 (PUMA) promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70064", "l": "a C28-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a (22S)-22-hydroxy C28-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51818", "l": "AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in) => ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55794", "l": "1-hydroxy-2-butanone + H2O + NAD(+) => butan-2-one + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507868", "l": "Aquaporins passively transport water into cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48165", "l": "epoxypheophorbide a + H2O => H(+) + red chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33522", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphinganine <=> (4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15697", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.140", "l": "\"licodione synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034525", "l": "1-naphthaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 1-naphthaldehyde + NAD+ + H2O = 1-naphthoic acid + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70939", "l": "L-methionine(in) = L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39420", "l": "3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31725", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60416", "l": "diglucosyl-enterobactin + H2O = H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40522", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749350", "l": "ATP-dependent release of CDT1 from the OCCM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705466", "l": "p-Y-STAT1,3,5 dimer enhances expression of SOCS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74990", "l": "erythrostominone(in) <=> erythrostominone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388832", "l": "PI3K binds CD28 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018516", "l": "2,4-dichlorobenzoyl-CoA reductase activity", "d": ["Catalysis of the reaction: 4-chlorobenzoyl-CoA + chloride + NADP+ = 2,4-dichlorobenzoyl-CoA + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029273", "l": "PI3K binds to p-6Y-SYK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700658", "l": "ceritinib-resistant ALK mutants don't bind ceritinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42201", "l": "corticosterone + NADP(+) => 11-dehydrocorticosterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392195", "l": "Gi activation by P2Y purinoceptor 12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72205", "l": "2 chloride(in) + hydrogencarbonate(out) => 2 chloride(out) + hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22828", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)", "d": []}, {"i": "EC:3.6.1.31", "l": "\"phosphoribosyl-ATP diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16270", "l": "aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) => 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14208", "l": "carnosine + S-adenosyl-L-methionine <=> anserine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202947", "l": "Caspase mediated cleavage of APC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507871", "l": "Aquaporins passively transport glycerol out of cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19896", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP <=> 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390133", "l": "YKI transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43081", "l": "O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864595", "l": "TFAP2B homodimer binds YEATS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76087", "l": "a dicarboxylate(in) + kynurenate(out) = a dicarboxylate(out) + kynurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376419", "l": "Formation of NR-MED1 Coactivator Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30311", "l": "7-methylxanthine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22158", "l": "GMP + H(+) + phosphate => GDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73045", "l": "creatine(out) => creatine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56653", "l": "12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58012", "l": "cyclic tetraadenylate = 2 5'-hydroxy-diadenylate 2',3'-cylic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983144", "l": "Transport of Antigen peptide in to ER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607756", "l": "TRAF6 oligomer autoubiquitinates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47677", "l": "ATP + N-acetyl-D-galactosamine => ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73740", "l": "dopamine(in) + 2 H(+)(out) => dopamine(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051265", "l": "diolein transacylation activity", "d": ["Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55221", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209903", "l": "Noradrenaline is converted to adrenaline (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390909", "l": "HRH2 binds hist (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49301", "l": "D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] => alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63743", "l": "2-phenylacetaldehyde + H(+) + NADH <=> 2-phenylethanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41451", "l": "2-oxoglutarate + L-isoleucine + O2 <=> (4S)-4-hydroxy-L-isoleucine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51003", "l": "[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine <=> [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9726875", "l": "HCNs:cAMP bind SNIs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39070", "l": "3-oxooctanedioyl-CoA + CoA <=> acetyl-CoA + hexanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140664", "l": "ATP-dependent DNA damage sensor activity", "d": ["A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36361", "l": "2 a plastoquinol + O2 => 2 a plastoquinone + 2 H2O + 4 hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54177", "l": "a long-chain fatty aldehyde + holo-[ACP] + NADP(+) => a long-chain fatty acyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27525", "l": "2,5-dihydroxypyridine + O2 <=> H(+) + N-formylmaleamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112429", "l": "Formation of FACT complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63279", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 <=> a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24809", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052717", "l": "tRNA-specific adenosine-34 deaminase activity", "d": ["Catalysis of the reaction: adenosine-34 + H2O = inosine-34 + NH3, in a tRNA-Ala molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59827", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate <=> L-glutamate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67318", "l": "(2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine => (2S,4R)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57131", "l": "H2O + 2 oxidized [azurin] + tyramine <=> (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450474", "l": "MK2 phosphorylates BRF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52341", "l": "a long-chain fatty acyl-AMP + holo-[mycocerosate synthase] => AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63941", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2 => 2 Fe(III)-[cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72179", "l": "2 Na(+)(out) + tauro-beta-muricholate(out) = 2 Na(+)(in) + tauro-beta-muricholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617410", "l": "GLI3R binds the GLI2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59314", "l": "D-galactono-1,5-lactone + H2O2 => D-galactose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022874", "l": "protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848250", "l": "ACBD6 binds LCFA-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50683", "l": "H2O + N-terminal L-glutaminyl-[protein] <=> N-terminal L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849094", "l": "ARHGAP35 binds RASA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031805", "l": "type 8 metabotropic glutamate receptor binding", "d": ["Binding to a type 8 metabotropic glutamate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55736", "l": "alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose = [(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.351", "l": "\"rhamnogalacturonan I rhamnosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114553", "l": "Activation of conventional Protein Kinase C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687099", "l": "p-S857 NCOA3:ETV4 bind MMP2 and MMP10 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663155", "l": "p-BMAL1:p-CLOCK,NPAS2 binds NR1D1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209960", "l": "Diiodinated tyrosine can be deiodinated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48455", "l": "ganglioside GA2 (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40918", "l": "1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9702849", "l": "CALCR binds gepants (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58706", "l": "rifampicin ortho-naphthoquinone carboxamide => rifampicin hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170846", "l": "TGFBR2 recruits TGFBR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23693", "l": "(R)-malate => H2O + maleate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75070", "l": "chloride(out) + 2 hydrogencarbonate(in) + Rb(+)(in) <=> chloride(in) + 2 hydrogencarbonate(out) + Rb(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018747", "l": "RHOQ GEFs activate RHOQ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10962", "l": "(R)-lactate => (S)-lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72350", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + veratrole <=> 3-methoxyphenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928619", "l": "PAK1 binds RAC1:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74986", "l": "Elongation of pre-rRNA transcript (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212642", "l": "L-Glutamine transport into neurons (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38136", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102912", "l": "(-)-lactol dehydrogenase activity", "d": ["Catalysis of the reaction: (-)-lactol + NAD <=> H+ + (-)-matairesinol + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44335", "l": "ATP + L-alanine + L-anticapsin <=> ADP + bacilysin + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49395", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620915", "l": "BTG1 gene expression is stimulated by FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9604328", "l": "AKT1 phosphorylates NOTCH4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12321", "l": "17-O-acetylnorajmaline + NADP(+) => 1,2-dihydrovomilenine + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660615", "l": "Defective RB1 does not translocate to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44489", "l": "3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592233", "l": "p38 MAPK phosphorylates PPARGC1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247843", "l": "secretion of WNT ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395320", "l": "Latent TGF-beta-1 binds integrins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983153", "l": "E1 mediated ubiquitin activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62340", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) = (+)-malbrancheamide C + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862700", "l": "CMKLR1 binds Resolvin E1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25432", "l": "beta-D-ribopyranose = beta-D-ribofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322971", "l": "Defective MUT does not isomerise L-MM-CoA to SUCC-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902314", "l": "hydroquinone binding", "d": ["Binding to hydroquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12012", "l": "ATP + thiamine = ADP + H(+) + thiamine phosphate", "d": []}, {"i": "EC:2.7.1.89", "l": "\"thiamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010385", "l": "double-stranded methylated DNA binding", "d": ["Binding to double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030763", "l": "isobutyraldoxime O-methyltransferase activity", "d": ["Catalysis of the reaction: 2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948757", "l": "AKT phosphorylates MKRN1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730886", "l": "Phosphorylation of SHC by SYK kinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73576", "l": "(E,E)-piperate + ATP + H(+) => (E,E)-piperoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29877", "l": "H(+) + L-serine + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44968", "l": "(2E)-tetradecenoyl-CoA + H(+) + NADPH = NADP(+) + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67078", "l": "H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine => L-histidyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69919", "l": "inosine(out) + 2 Na(+)(out) = inosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54533", "l": "H2O + N-(4-oxoglutaryl)-L-cysteinylglycine => 2-oxoglutarate + L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400204", "l": "PPARA binds RXRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27361", "l": "chloride + S-adenosyl-L-methionine = chloromethane + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35517", "l": "CoA + salvianin => 4'''-demalonylsalvianin + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1963589", "l": "ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748991", "l": "XDH oxidises 6MP to 6TU (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196773", "l": "COASY phosphorylates DP-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31672", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74487", "l": "anthranilate + 2 ATP + O-methyl-L-tyrosine + S-adenosyl-L-methionine = (-)-4'-methoxycyclopeptine + 2 AMP + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375160", "l": "NCAM1 binds to ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709109", "l": "DHFR dimer binds DHFR inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663132", "l": "p-BMAL1:p-CLOCK,NPAS2 binds DBP gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38672", "l": "sphinganine 1-phosphate(in) => sphinganine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45184", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050134", "l": "N6-methyl-lysine oxidase activity", "d": ["Catalysis of the reaction: N(6)-methyl-L-lysine + H2O + O2 = L-lysine + formaldehyde + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51454", "l": "beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.96", "l": "\"D-aminoacyl-tRNA deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21832", "l": "3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine = 3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.83", "l": "\"3,7-dimethylquercetin 4'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73078", "l": "luteolin + S-adenosyl-L-methionine <=> H(+) + luteolin 7-methyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381545", "l": "Formation of the IGF:IGFBP5:ALS complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990050", "l": "phosphatidic acid transfer activity", "d": ["Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18460", "l": "D-ribulose 5-phosphate <=> (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70705", "l": "D-cycloserine(out) + H(+)(out) => D-cycloserine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879930", "l": "STAT5 is recruited by JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37553", "l": "2-oxoglutarate + D-kanosamine 6-phosphate => 3-dehydro-D-glucose 6-phosphate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64881", "l": "CDP + H2O => CMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102883", "l": "(+)-beta-chamigrene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-beta-chamigrene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39089", "l": "(2E)-decenedioyl-CoA + H2O2 => decanedioyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380780", "l": "Activation of Src (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35085", "l": "acetate + N'-monoacetylchitobiose-6'-phosphate => diacetylchitobiose-6'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0002113", "l": "interleukin-33 binding", "d": ["Binding to interleukin-33."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938251", "l": "CSF2 (GM-CSF) gene expression is stimulated by RUNX1 and CREBBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709109", "l": "DHFR dimer binds DHFR inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15433", "l": "(2S)-naringenin + dimethylallyl diphosphate = diphosphate + sophoraflavanone B", "d": []}, {"i": "EC:2.5.1.70", "l": "\"naringenin 8-dimethylallyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462039", "l": "Pro-HNP1-4 are cleaved to biologically active defensin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419166", "l": "GEFs activate RhoA,B,C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25873", "l": "H2O2 + pyridine => H2O + pyridine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66327", "l": "iodide(out) <=> iodide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012671", "l": "p-STAT5 binds CISH, SOCS1 and SOCS2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74114", "l": "H(+) + hypotaurine + NADH + O2 <=> H2O + NAD(+) + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197562", "l": "NOTCH2 stimulates HES1 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15371", "l": "2-carboxy-cis,cis-muconate + 2 H(+) => 2,3-dihydroxybenzoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49752", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate = CO2 + 2 H2O + NAD(+) + proviolacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865774", "l": "TTLLs polyglutamylate tubulin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797554", "l": "ABP1 binds SHANK proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55171", "l": "[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27862", "l": "3'-GMP + H2O = guanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867047", "l": "PTPN3 dephosphorylates EPS15 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35872", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19423", "l": "(R)-1,2-epoxypropane + coenzyme M => (R)-2-hydroxypropyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789092", "l": "NOX2 generates superoxide anion from oxygen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9631068", "l": "HSPA8:substrate binds late endosomal phospholipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678998", "l": "Endosomal TLRs pass through the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9704297", "l": "CHRM2 binds CHRM2 antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388814", "l": "Grb2 binds CD28 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50325", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450088", "l": "GLUT1 tetramer binds 4xATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317332", "l": "PIP3 recruits AKT to the membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203070", "l": "Association of profilin with monomeric actin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047600", "l": "abequosyltransferase activity", "d": ["Catalysis of the reaction: CDP-abequose + D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid = CDP + D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28309", "l": "beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose <=> beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65117", "l": "2-oxoglutarate + aculene B + O2 => aculene A + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40543", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009924", "l": "octadecanal decarbonylase activity", "d": ["Catalysis of the reaction: octadecanal = heptadecane + CO."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3857336", "l": "CEBPB homodimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981931", "l": "RAC1 and CDC42 activate PAK2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65168", "l": "AH2 + O2 + preaustinoid A = A + H2O + preaustinoid A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65616", "l": "A + cholest-4-en-3-one + H2O = 25-hydroxycholest-4-en-3-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56294", "l": "4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => fenbendazole + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5656070", "l": "FGFBPs bind FGFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990883", "l": "rRNA cytidine N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34836", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine => a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028583", "l": "Phosphorylation of YAP by LATS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071614", "l": "linoleic acid epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts linoleic acid to a cis-epoxyoctadecenoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11181", "l": "ATP + L-asparagine + tRNA(Asn) => AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72191", "l": "cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57402", "l": "acetate + H(+) + narcotine hemiacetal => 3-O-acetylpapaveroxine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74955", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + holo-[ACP] = a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008890", "l": "glycine C-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15436", "l": "(2S)-naringenin + dimethylallyl diphosphate <=> diphosphate + sophoraflavanone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28953", "l": "H(+)(out) + L-arabinose(out) => H(+)(in) + L-arabinose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901680", "l": "sulfur-containing amino acid secondary active transmembrane transporter activity", "d": ["Enables the transfer of sulfur-containing amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50667", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42221", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.212", "l": "\"hyaluronan synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25075", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.101", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029983", "l": "Dimerization of FGFR2 ligand-independent mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46270", "l": "a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604387", "l": "p-4S-NICD4 binds YWHAZ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24545", "l": "H2O + L-lysyl-[protein] + O2 => (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420202", "l": "Secretin receptor binds secretin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55931", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14025", "l": "H(+) + H2O + sepiapterin = NH4(+) + xanthopterin-B2", "d": []}, {"i": "EC:3.5.4.24", "l": "\"sepiapterin deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13927", "l": "holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine => (3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10519", "l": "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) <=> (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450494", "l": "HuR binds mRNAs in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45938", "l": "4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA => 3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17225", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] = 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.7.1", "l": "\"6-hydroxynicotinate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46496", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in) = N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983153", "l": "E1 mediated ubiquitin activation (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.127", "l": "\"3-(3-hydroxy-phenyl)propanoic acid hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50828", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38964", "l": "ATP + H2O + leukotriene C4(in) => ADP + H(+) + leukotriene C4(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29693", "l": "alpha-D-glucose 1-phosphate + alpha-maltotriose => alpha-maltotetraose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13570", "l": "ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016707", "l": "gibberellin 3-beta-dioxygenase activity", "d": ["Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 3-beta-hydroxy-gibberellin + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109700", "l": "AKT2 binds PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56638", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59741", "l": "L-cysteinyl-[protein] + octadecanoyl-CoA => CoA + S-octadecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37300", "l": "H2O + L-alanyl-L-threonine => L-alanine + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54594", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0010852", "l": "cyclase inhibitor activity", "d": ["Binds to and decreases the activity of an enzyme that catalyzes a ring closure reaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800798", "l": "The PIDDosome binds CASP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15800", "l": "bilirubin IXalpha + NAD(+) <=> biliverdin IXalpha + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58884", "l": "AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 = A + chloramphenicol + 2 H2O", "d": []}, {"i": "EC:1.14.99.67", "l": "\"alpha-N-dichloroacetyl-p-aminophenylserinol N-oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938815", "l": "RNF152 polyubiquitinates RRAGA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961619", "l": "CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65217", "l": "3-oxododecanoyl-CoA + H2O => 3-oxododecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465940", "l": "atRAL is reduced to atROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682010", "l": "ATG10:ATG12 binds ATG5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853920", "l": "VENTX binds the CDKN2A gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47474", "l": "(3E)-tetradecenoyl-CoA + NADP(+) => (2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10892", "l": "(2R,3S)-3-isopropylmalate + NAD(+) = (2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.28", "l": "\"N-acetylmuramoyl-L-alanine amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14265", "l": "(S)-4-amino-5-oxopentanoate = 5-aminolevulinate", "d": []}, {"i": "EC:5.4.3.8", "l": "\"glutamate-1-semialdehyde 2,1-aminomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13931", "l": "putrescine + urea => agmatine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77608", "l": "Binding of A1CF to stem-looped RNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73402", "l": "D-aspartate(in) + sulfate(out) <=> D-aspartate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905763", "l": "MTREC complex binding", "d": ["Binding to a MTREC complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20294", "l": "3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) => 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68172", "l": "2-oxoglutarate + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + O2 = CO2 + H2O + isodomoate A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69942", "l": "6-deoxotyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxytyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75656", "l": "(9Z)-octadecenoate + O2 => (8R)-hydroperoxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60692", "l": "(E)-non-2-enal + H2O + NADP(+) = (E)-non-2-enoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647631", "l": "GSDMD (1-275) binds PIPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71073", "l": "L-arginine(out) + L-cysteine(in) => L-arginine(in) + L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60715", "l": "(+)-artemisinic alcohol + NAD(+) <=> (+)-artemisinic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76466", "l": "CYP4A11 12-hydroxylates DDCX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21394", "l": "2-phenylacetate + 2 H(+) + NADH => 2-phenylacetaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.2.11", "l": "\"(3R)-3-[(carboxylmethyl)amino]fatty acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004487", "l": "methylenetetrahydrofolate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17326", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA => (S)-2-succinylamino-6-oxoheptanedioate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22502", "l": "(E)-feruloylacetyl-CoA + CO2 + CoA => (E)-feruloyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660662", "l": "ASC binds Caspase-8 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19723", "l": "(9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4549368", "l": "Defective ALG2 does not transfer a second Man to N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51132", "l": "a purine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a purine nucleobase", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864426", "l": "TFAP2A,TFAP2C homodimers bind the CGB gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3321918", "l": "Defective MTR does not transfer CH3 group from MTHF to cob(I)alamin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73642", "l": "CTP(out) + ITP(in) <=> CTP(in) + ITP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9716947", "l": "ESR1 binds ESR1 agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-170120", "l": "Translocation of Cdc25B to the cytoplasm (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865454", "l": "CBFB binds RUNX3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70853", "l": "H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in) => H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18869", "l": "ATP + L-xylulose = ADP + H(+) + L-xylulose 5-phosphate", "d": []}, {"i": "EC:2.7.1.53", "l": "\"L-xylulokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11515", "l": "salicyl alcohol + UDP-alpha-D-glucose <=> H(+) + salicin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13720", "l": "2-C-methyl-D-erythritol 4-phosphate + NADP(+) <=> 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665748", "l": "FMNL2 binds RHOC:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624494", "l": "RAF1 binds p21 RAS:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047749", "l": "cholestanetriol 26-monooxygenase activity", "d": ["Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74726", "l": "Dissociation of insulin from insulin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61034", "l": "5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2172666", "l": "RB1 binds condensin II (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36824", "l": "1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol => CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802919", "l": "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139842", "l": "Binding of Syk tyrosine kinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23979", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + ATP <=> a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10676", "l": "(2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047756", "l": "chondroitin 4-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851436", "l": "CFHR dimers bind C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467738", "l": "A2E translocates to RPE cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018558", "l": "5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity", "d": ["Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20359", "l": "3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) => 3-phenylpropanoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2530429", "l": "Formation of soluble VTN:C5b-C9  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33943", "l": "H(+) + 2 L-arginine + 3 NADH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64761", "l": "H2O + S-ethyl-L-cysteine => ethanethiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445704", "l": "Calcium Binds Caldesmon (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433599", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18934", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA => (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35317", "l": "3-oxooctadecanoyl-CoA + CO2 + CoA => H(+) + hexadecanoyl-CoA + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351208", "l": "Spermidine  => N-acetylated spermidine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013438", "l": "RHOD binds effectors at the endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68749", "l": "alpha-D-glucose 1-phosphate + O-phospho-L-seryl-[protein] => alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1470009", "l": "Phosphorylation of STATs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196773", "l": "COASY phosphorylates DP-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204824", "l": "Interaction of Tie2 and Ang4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23274", "l": "an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP => an N(6)-alkylaminopurine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3325540", "l": "Defective extracellular BTD does not hydrolyse BCTN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67064", "l": "AH2 + asnovolin K = A + asnovolin A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0005539", "l": "glycosaminoglycan binding", "d": ["Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222755", "l": "Peroxynitrite is reduced to nitrite by Tpx (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190682", "l": "Connexin synthesis (generic) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32958", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68505", "l": "(2Z,6Z)-farnesyl diphosphate => (Z)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38313", "l": "daunorubicin + H(+) + S-adenosyl-L-homocysteine => carminomycin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32248", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) => (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950387", "l": "CANX binds EBI3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:1902282", "l": "voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869683", "l": "oxPL binds LBP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004723", "l": "calcium-dependent protein serine/threonine phosphatase activity", "d": ["Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions."]}, {"i": "REACT:R-HSA-2025882", "l": "Calcineurin dephosphorylates NFATC1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27888", "l": "3'-AMP + H(+) => 2',3'-cyclophospho-AMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10858", "l": "a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + H(+) + UDP => a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65022", "l": "CoA + H(+) + N(2)-succinyl-L-ornithine => L-ornithine + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64714", "l": "H(+) + NADPH + propanal => 1-propanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26031", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30840", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-talose => UDP-N-acetyl-beta-L-fucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200406", "l": "CPT1A,B transfers PALM to CAR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25345", "l": "H2O + urea <=> carbamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40034", "l": "ent-copalyl diphosphate + H2O <=> diphosphate + ent-manool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34354", "l": "(2E)-geranial + H2O + NAD(+) <=> geranate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102258", "l": "1,3-diacylglycerol acylhydrolase activity", "d": ["Catalysis of the reaction: H2O + a 1,3-diglyceride = a monoglyceride + a fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42783", "l": "adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54868", "l": "(2E)-butenoyl-[ACP] + H(+) + NADH = butanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24682", "l": "5,10-methylenetetrahydromethanopterin + NADP(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419214", "l": "5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011543", "l": "DCA binds PDK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848864", "l": "PTK6 binds ARAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21181", "l": "1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol => D-glucose + indole-3-acetyl-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445700", "l": "Myosin Binds ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696356", "l": "OSCAR binds collagen and SP-D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43983", "l": "H(+) + hexadecanoate + NADPH + O2 <=> 15-hydroxyhexadecanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098650", "l": "peptidyl-proline 4-dioxygenase binding", "d": ["Binding to a peptidyl-proline 4-dioxygenase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679044", "l": "FKBP1A binds sirolimus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24677", "l": "ATP + cytidine <=> ADP + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624952", "l": "Assembly of the retrograde IFT train (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52349", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65937", "l": "beta-D-mannose => beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0008240", "l": "tripeptidyl-peptidase activity", "d": ["Catalysis of the release of an N-terminal tripeptide from a polypeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.56", "l": "\"7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43344", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) = [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}, {"i": "EC:2.7.7.73", "l": "\"sulfur carrier protein ThiS adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879930", "l": "STAT5 is recruited by JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60024", "l": "(R,R)-chrysanthemyl diphosphate + H2O = (R,R)-chrysanthemol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31406", "l": "all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) <=> all-trans-4,4'-diaponeurosporene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34665", "l": "3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18107", "l": "ADP + Ca(2+)(out) + H(+) + phosphate => ATP + Ca(2+)(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54535", "l": "H2O + N-(4-oxoglutaryl)-L-cysteinylglycine <=> 2-oxoglutarate + L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791076", "l": "Expression of ADD1 (Adducin alpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24633", "l": "2 H2O + 3 NADP(+) + NH4(+) => 5 H(+) + 3 NADPH + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51196", "l": "chloride(out) + Na(+)(out) + serotonin(out) = chloride(in) + Na(+)(in) + serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28276", "l": "(R)-S-adenosyl-L-methionine => (S)-S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10314", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) => H(+) + NADH + O2 + terephthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749197", "l": "ORC1 binds to H4K20me2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010487", "l": "thermospermine synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methioninamine + spermidine = S-methyl-5'-thioadenosine + thermospermine + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035473", "l": "lipase binding", "d": ["Binding to a lipase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71380", "l": "D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out) => D-aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57985", "l": "(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose => (20S)-ginsenoside Rd + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354087", "l": "Recruitment of GRB2 to p-PTK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21615", "l": "D-gluconate <=> 2-dehydro-3-deoxy-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2484822", "l": "Kinetochore assembly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23368", "l": "H(+) + phenylglyoxylate = benzaldehyde + CO2", "d": []}, {"i": "EC:4.1.1.7", "l": "\"benzoylformate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64216", "l": "2-carboxy-L-lyxonate + H(+) = CO2 + L-lyxonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52107", "l": "a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22231", "l": "H(+) + NADH + presqualene diphosphate <=> diphosphate + NAD(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004140", "l": "dephospho-CoA kinase activity", "d": ["Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41466", "l": "ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46576", "l": "H(+) + NADPH + O2 + sitosterol = 2 H2O + NADP(+) + stigmasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683769", "l": "O-glycosylation of 3a is terminated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47933", "l": "(2S)-3-sulfolactaldehyde + H2O + NAD(+) => (2S)-3-sulfolactate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514865", "l": "cGMP dissociates from CNG channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.-.-.-", "l": "\"Lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047367", "l": "quercetin-3,3'-bissulfate 7-sulfotransferase activity", "d": ["Catalysis of the reaction: quercetin 3,3'-bissulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3',7-trissulfate + adenosine 3',5'-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25922", "l": "7-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-7-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0008177", "l": "succinate dehydrogenase (ubiquinone) activity", "d": ["Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46676", "l": "(4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+) = (6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.461014234140904", "identifiers": [{"i": "GO:0140358", "l": "P-type transmembrane transporter activity", "d": ["Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6793666", "l": "MDM2 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30773", "l": "D-ribose + guanine => guanosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27959", "l": "cytidine + H2O => cytosine + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66153", "l": "acetyl-CoA + noradrenaline => CoA + H(+) + N-acetylnoradrenaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24390", "l": "alpha-D-ribose 1-phosphate + uracil => phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44519", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.332", "l": "\"bacteriochlorophyllide d C-8(2)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786257", "l": "DCTPP1 hydrolyses 5idCTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211874", "l": "CYP2S1 4-hydroxylates atRA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209910", "l": "Iodide is taken up by thyroid epithelial cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63839", "l": "hexadecanoate + O2 <=> (2R)-2-hydroperoxyhexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46847", "l": "4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358919", "l": "MSH2:MSH3 exchanges ADP for ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52144", "l": "3-phosphonopyruvate + acetyl-CoA + H2O = (R)-2-(phosphonomethyl)malate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.19", "l": "\"2-phosphonomethylmalate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442387", "l": "ZIP8 mediates zinc influx into cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33725", "l": "a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39653", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + H(+) => 6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983150", "l": "Proteasomal cleavage of substrate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14537", "l": "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)", "d": []}, {"i": "EC:3.5.4.20", "l": "\"pyrithiamine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61844", "l": "solasodine + UDP-alpha-D-glucose = H(+) + solasodine 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468040", "l": "Cohesin binds PDS5 and WAPAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35805", "l": "7,8-dihydroneopterin 2'-phosphate + H(+) => 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684350", "l": "pp1a forms a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.97", "l": "\"endo-alpha-N-acetylgalactosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25020", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803234", "l": "Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61579", "l": "(4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+) <=> (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73425", "l": "L-asparagine(in) => L-asparagine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141310", "l": "FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26534", "l": "3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.36", "l": "\"3-hydroxypropionyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604712", "l": "Initial activation of proMMP7 by trypsin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40436", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679239", "l": "ULK complex translocates to the ER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24791", "l": "(2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate => (2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41559", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2 <=> (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5679205", "l": "ULK1 phosphorylates Beclin-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11825", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O => (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694442", "l": "CNIH2,3 bind GRIA1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61593", "l": "H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine => 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74805", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210805", "l": "Removal of miRNA passenger strand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797974", "l": "LRRTMs bind NRXNs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134914", "l": "Beta-catenin migrates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41309", "l": "(9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66382", "l": "ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycodeoxycholate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51142", "l": "(10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004306", "l": "ethanolamine-phosphate cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373889", "l": "lactate + H+ [cytosol] <=> lactate + H+ [extracellular] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43290", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004072", "l": "aspartate kinase activity", "d": ["Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426164", "l": "SREBP1A,2 binds the SC5DL promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43625", "l": "2-aminomalonate semialdehyde + H(+) => aminoacetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827882", "l": "SOX17 and TFAP2C bind the PRDM1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247960", "l": "Activation of p38 MAPK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731077", "l": "SARS-CoV-1 8b binds to IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29181", "l": "a menaquinone + 2 H(+) + 2 superoxide => a menaquinol + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129357", "l": "Fibrillin C-terminal processing (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51652", "l": "D-mannonate + NAD(+) = H(+) + keto-D-tagaturonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649724", "l": "LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23908", "l": "H(+) + 2 methylcob(III)alamin-[methionine synthase] + NADP(+) + 2 S-adenosyl-L-homocysteine = 2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine", "d": []}, {"i": "EC:1.16.1.8", "l": "\"[methionine synthase] reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12853", "l": "(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose = dhurrin + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.85", "l": "\"cyanohydrin beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770145", "l": "Formation of the Spliceosomal Bact complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419049", "l": "ROCK activation by RHO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.-.-", "l": "\"Acting on a sulfur group of donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.16", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005223", "l": "intracellular cGMP-activated cation channel activity", "d": ["Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61807", "l": "ATP + H(+) + L-alanine <=> diphosphate + L-alanyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084505", "l": "Laminins bind HSPG2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781953", "l": "YOD1 binds VCP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014454", "l": "RHOG translocates to the ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849055", "l": "PTK6 binds ARHGAP35 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-870269", "l": "Gastrin binds to CCK-B receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000031", "l": "mannosylphosphate transferase activity", "d": ["Catalysis of the transfer of a mannosylphosphate group from one compound to another."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56025", "l": "H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42359", "l": "(9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870461", "l": "RABGGTA and RABGGTB bind (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55781", "l": "all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate => all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9621179", "l": "Cinaciguat binds sGC:NO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57818", "l": "2-deoxy-D-ribose 5-phosphate + guanine => dGMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.101", "l": "\"2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043792", "l": "enamidase activity", "d": ["Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O = 2-formylglutarate + NH4."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047126", "l": "N5-(carboxyethyl)ornithine synthase activity", "d": ["Catalysis of the reaction: N(5)-[1(S)-1-carboxyethyl]-L-ornithine + H2O + NADP+ = L-ornithine + H+ + NADPH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034057", "l": "RNA strand-exchange activity", "d": ["Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2484822", "l": "Kinetochore assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-990489", "l": "Kinesin-13 is a dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987007", "l": "p-STAT1 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211950", "l": "CYP24A1 24-hydroxylates CTL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44314", "l": "glycerol + H(+) + tetradecanoate => 1-tetradecanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65904", "l": "3-hydroxy-L-kynurenine + glyoxylate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679205", "l": "ULK1 phosphorylates Beclin-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26059", "l": "Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine = methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+)", "d": []}, {"i": "EC:2.1.1.248", "l": "\"[methylamine--corrinoid protein] Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60401", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42931", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12201", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 => CO2 + mugineate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018837", "l": "2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity", "d": ["Catalysis of the reaction: 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate = cis -4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35816", "l": "4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) => 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11803", "l": "H2O + NAD(+) <=> AMP + beta-nicotinamide D-ribonucleotide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19902", "l": "L-tryptophan + O2 => alpha,beta-didehydrotryptophan + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39312", "l": "(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093342", "l": "SDC2 multimerises (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102279", "l": "lecithin:11-cis retinol acyltransferase activity", "d": ["Catalysis of the reaction: an 11-cis retinol-[cellular-retinol-binding-protein] + a phosphatidylcholine <=> a cellular-retinol-binding protein + an 11-cis-retinyl ester + a 1-lysophosphatidylcholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16744", "l": "a 2-acylglycerol + an acyl-CoA <=> a 1,2-diacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73860", "l": "1-methylnicotinamide(out) => 1-methylnicotinamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57650", "l": "equisetin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trichosetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63052", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483219", "l": "PC is exchanged with PI by PITPNB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705137", "l": "TBK1 or IKBKE forms homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20854", "l": "ADP + 2 H(+)(out) + phosphate => ATP + H(+)(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74412", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2167942", "l": "Collagen type XIII ectodomain shedding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72583", "l": "(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+) = 3,22-dioxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38270", "l": "2-methylfumaryl-CoA <=> 3-methylfumaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707690", "l": "BACH1 binds MAFK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381091", "l": "IRE1 dimer autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450533", "l": "PKCdelta phosphorylates HuR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008941", "l": "nitric oxide dioxygenase activity", "d": ["Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65338", "l": "chrodrimanin A + H2O + NADP(+) => chrodrimanin T + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72699", "l": "acrylate + H(+) + NADH = NAD(+) + propanoate", "d": []}, {"i": "EC:1.3.1.125", "l": "\"acrylate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30216", "l": "a menaquinol + 2 nitric oxide => a menaquinone + H2O + nitrous oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9752950", "l": "Expression of Olfactory Receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63690", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445084", "l": "Phosphorylation of L1 by SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33240", "l": "L-threonine + NAD(+) => aminoacetone + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63635", "l": "a long-chain fatty acyl-AMP + holo-[ACP] <=> a long-chain fatty acyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32848", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol => a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54434", "l": "a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate => 2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67448", "l": "(2R)-2-hydroxyoctadecanoyl-CoA = formyl-CoA + heptadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23137", "l": "a primary amine + S-adenosyl-L-methionine => a methylated primary amine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602458", "l": "Activation of proMMP10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873926", "l": "IFNG dimer binds IFNGR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46327", "l": "3-oxochol-4-en-22-oyl-CoA + A <=> 3-oxochola-4,17-dien-22-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9609310", "l": "β-blockers bind ADRB1,2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62164", "l": "beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O = D-glucosamine + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792491", "l": "TP53 stimulates CCNG1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4411402", "l": "Activation of NLK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56813", "l": "2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 => 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13707", "l": "alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP => alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32290", "l": "(2R,3S)-3-isopropylmalate <=> (2S)-2-isopropylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202466", "l": "Interaction of Bcl10 to CARMA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65818", "l": "A + ADP + 2 Co(I)-[methylamine-specific corrinoid protein] + 3 H(+) + phosphate => AH2 + ATP + 2 Co(II)-[methylamine-specific corrinoid protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37261", "l": "2-oxobutanoate + H(+) + NADH + NH4(+) => (2S)-2-aminobutanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004084", "l": "branched-chain-amino-acid transaminase activity", "d": ["Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679044", "l": "FKBP1A binds sirolimus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047808", "l": "D(-)-tartrate dehydratase activity", "d": ["Catalysis of the reaction: D-tartrate = H2O + oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68472", "l": "(2Z,6Z)-farnesyl diphosphate = (E)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60662", "l": "hydroquinone + NAD(+) => 1,4-benzoquinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10313", "l": "H(+) + NADH + O2 + terephthalate => (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176116", "l": "Recruitment and activation of Chk1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71346", "l": "chloride(out) + L-histidine(out) + 2 Na(+)(out) <=> chloride(in) + L-histidine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801675", "l": "PLK2 phosphorylates NPM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67947", "l": "2-hydroxyhexadecanoate + O2 <=> 2-oxohexadecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51282", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47688", "l": "cis-4-hydroxy-L-proline + NADP(+) = Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008996", "l": "ribonuclease G activity", "d": ["Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30518", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + S-methyl-5'-thioadenosine + thermospermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41436", "l": "(9Z)-octadecenoyl-CoA + cholesterol = cholesteryl (9Z-octadecenoate) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52897", "l": "2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin => 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.115", "l": "\"anthocyanidin 3-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71056", "l": "L-cysteine(out) + L-methionine(in) => L-cysteine(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68282", "l": "CoA + O-pentanoyl-L-seryl-[protein] => L-seryl-[protein] + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351913", "l": "Caspase-mediated cleavage of TJP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9663511", "l": "BIL binds GSTA1, FABP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186773", "l": "PDGF dimer binds two receptors simultaneously (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350408", "l": "PK binds to VANG at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74614", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-glucosamine(out) <=> UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-glucosamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2301205", "l": "SETD8 monomethylates histone H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70212", "l": "2-oxoglutarate + GDP-D-glycero-alpha-D-manno-heptose => (S)-2-hydroxyglutarate + GDP-D-glycero-4-keto-alpha-D-lyxo-heptose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036429", "l": "adenosylcobinamide kinase (ATP-specific) activity", "d": ["Catalysis of the reaction: adenosylcobinamide + ATP = adenosylcobinamide phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33168", "l": "2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57931", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine <=> ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50845", "l": "(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18283", "l": "fumarate + H(+) + NADH => NAD(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47773", "l": "a guanosine in 21S rRNA + S-adenosyl-L-methionine => a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689544", "l": "UCHL5 binds INO80 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010074", "l": "ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11665", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate => 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22788", "l": "dimethylsulfonioacetate + L-homocysteine = (methylsulfanyl)acetate + H(+) + L-methionine", "d": []}, {"i": "EC:2.1.1.3", "l": "\"thetin--homocysteine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33748", "l": "a 1-acyl-sn-glycerol + ATP => a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44752", "l": "2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48266", "l": "H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate => H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14819", "l": "4-fumarylacetoacetate => 4-maleylacetoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15753", "l": "GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate", "d": []}, {"i": "EC:6.3.4.4", "l": "\"adenylosuccinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32216", "l": "(6R)-NADHX => (6S)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13099", "l": "a (2E)-enoyl-[ACP] + H2O => a (3R)-hydroxyacyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474196", "l": "Collagen type II degradation by MMP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635861", "l": "NUMB:ITCH binds GLI1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56464", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.70", "l": "\"8-hydroxyfuranocoumarin 8-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9656947", "l": "OGG1beta translocates to mitochondria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11579", "l": "ATP + thiamine <=> AMP + H(+) + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254291", "l": "ERBB4s80 binds STAT5A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38431", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071968", "l": "lipid A-core heptosyltransferase activity", "d": ["Catalysis of the reaction: galactosyl-glucosyl3-heptosyl3-KDO2-lipid A-bisphosphate + ADP-L-glycero-beta-D-manno-heptose = lipid A-core + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60755", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone <=> CoA + jasmolin I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46999", "l": "6-hydroxy-N-methylmyosmine + H2O <=> 6-hydroxypseudooxynicotine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.40", "l": "\"anthraniloyl-CoA monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862300", "l": "LYZ binds bacterial peptidoglycan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10516", "l": "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.166", "l": "\"hydroxycyclohexanecarboxylate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166091", "l": "IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29724", "l": "glyoxylate(in) => glyoxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197958", "l": "FPGS-2 transforms THF to THFPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5444511", "l": "Formation of MSH2:MSH3 Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655827", "l": "Expression of 7-Dehydrocholesterol Reductase (DHCR7) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981539", "l": "C3b binds to cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23645", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28487", "l": "Fe(2+)(in) => Fe(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60078", "l": "4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+) => 4beta-hydroxymethyl-4alpha-methylzymosterol + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36512", "l": "(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA => (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21888", "l": "(1S,2S)-OPC-8 + NADP(+) = (9S,13S,15Z)-12-oxophyto-10-15-dienoate + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.42", "l": "\"12-oxophytodienoate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011145", "l": "LHX2,(LHX9) binds the ROBO3 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953013", "l": "E2F7 binds E2F8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209160", "l": "Phosphorylated HOP phosphorylates DOME (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.131", "l": "\"xylan alpha-1,2-glucuronosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.34", "l": "\"2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0003707", "l": "nuclear steroid receptor activity", "d": ["Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31770", "l": "2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine <=> L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32543", "l": "(2E)-geranyl diphosphate + H2O = 1,8-cineole + diphosphate", "d": []}, {"i": "EC:4.2.3.108", "l": "\"1,8-cineole synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29932", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP => ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18711", "l": "AH2 + NH4(+) + sulfoacetaldehyde => A + H2O + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55717", "l": "(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O => (9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33204", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0099142", "l": "intracellularly ATP-gated ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24764", "l": "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate", "d": []}, {"i": "EC:5.1.3.23", "l": "\"UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57036", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose = (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl](n) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44975", "l": "(R)-carnitine + hexanoyl-CoA <=> CoA + O-hexanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63237", "l": "ATP + streptomycin => 6-O-adenylylstreptomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33696", "l": "C20 sphinganine + NADP(+) => 3-oxoeicosasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804379", "l": "PRMT5 binds TTC5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42980", "l": "L-tyrosine = 2-aminoprop-2-enoate + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60277", "l": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863973", "l": "Fusion of ERC and phagosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3240957", "l": "Formation of PRC2-EZH2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032399", "l": "HECT domain binding", "d": ["Binding to a HECT, 'Homologous to the E6-AP Carboxy-Terminus', domain of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16945", "l": "(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)", "d": []}, {"i": "EC:2.1.2.10", "l": "\"aminomethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51701", "l": "S-adenosyl-L-methionine + xanthogalenol => 4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57580", "l": "S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thiol-D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466370", "l": "NRF1:PPARGC1B binds the CYCS promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50062", "l": "ADP + glycochenodeoxycholate(out) + H(+) + phosphate => ATP + glycochenodeoxycholate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41757", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 => 1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39464", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA => (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67662", "l": "a (8Z,11Z)-eicosadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (11Z)-eicosenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804596", "l": "APAF1:CYCS binds APIP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8987007", "l": "p-STAT1 dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48328", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32131", "l": "(2S)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864412", "l": "TFAP2A,TFAP2C homodimers bind the CGA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0005527", "l": "macrolide binding", "d": ["Binding to a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865107", "l": "MICAL1 produces NADP+, H2O2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047986", "l": "hydrogen-sulfide S-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + S(2-) = CoA + thioacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811508", "l": "ING2-bound EP300 acetylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9724745", "l": "PLG(20-810) binds aprotinin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47002", "l": "NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14327", "l": "daphnin + H(+) + UDP => 7,8-dihydroxycoumarin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047910", "l": "galactose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-galactose + NADP+ = D-galactonolactone + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37659", "l": "anthraniloyl-CoA + methanol = CoA + O-methyl anthranilate", "d": []}, {"i": "EC:2.3.1.232", "l": "\"methanol O-anthraniloyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3159259", "l": "MMAA:MUT binds AdoCbl (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420274", "l": "GIP receptor binds gastric inhibitory peptide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866269", "l": "ARRB bind GPCRs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74813", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33804", "l": "H2O + L-histidinal + NAD(+) => 2 H(+) + L-histidine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32709", "l": "(2R,4S)-bornyl diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928619", "l": "PAK1 binds RAC1:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73231", "l": "2,4,6-trichlorophenol + FADH2 + O2 = 2-chloro-6-hydroxy-1,4-benzoquinone + 2 chloride + FAD + 3 H(+)", "d": []}, {"i": "EC:1.14.14.173", "l": "\"2,4,6-trichlorophenol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186798", "l": "GAP binds to PDGF-beta receptors only (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60284", "l": "N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50874", "l": "(5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate => (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682011", "l": "LC3 binds ATG7 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74392", "l": "methylamine(out) => methylamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67810", "l": "H(+) + N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine => L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22103", "l": "3,5-dibromo-4-hydroxybenzonitrile + 2 H2O <=> 3,5-dibromo-4-hydroxybenzoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60803", "l": "2-oxoglutarate + gibberellin A53 + O2 <=> CO2 + gibberellin A44 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40796", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56976", "l": "4-methylphenol + H2O + 2 oxidized [azurin] = 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264848", "l": "apoA-I binds to CUBN:AMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44223", "l": "15-hydroxypentadecanoate + ATP + CoA <=> 15-hydroxypentadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674563", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75740", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH => 10-oxooctadecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16820", "l": "6-phospho-D-gluconate + NADP(+) <=> 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2186780", "l": "Degradation of Ub-SMAD7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782138", "l": "ERCC5 and RPA bind TC-NER site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44057", "l": "2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674385", "l": "p-T,Y MAPKs dimerize (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052604", "l": "delta-tocopherol cyclase activity", "d": ["Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone = delta-tocopherol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29674", "l": "Ca(2+)(in) <=> Ca(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69981", "l": "(22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (22R,23R)-22,23-dihydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693598", "l": "ATM phosphorylates NBN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35895", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685953", "l": "SIRT6 deacetylates RBBP8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58855", "l": "(6E)-8-oxogeraniol + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757954", "l": "N4BP1 binds IKBKG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73975", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42868", "l": "norspermine + S-adenosyl 3-(methylsulfanyl)propylamine = caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.127", "l": "\"caldopentamine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23710", "l": "[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+) => [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39922", "l": "1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O <=> 1-O-(alk-1-enyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654569", "l": "Activated FGFR1 binds FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.106", "l": "\"O-acetyl-ADP-ribose deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050262", "l": "ribosylnicotinamide kinase activity", "d": ["Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H+ + nicotinamide mononucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707586", "l": "FeHM oxidises LDL,HDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65285", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate => 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Thr-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29491", "l": "(2E,6E)-farnesyl diphosphate = cis-muurola-4(14),5-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641229", "l": "TLE oligomerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44683", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875374", "l": "MET binds LRIG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20223", "l": "(6S)-10-formyltetrahydrofolate + ADP + phosphate => (6S)-5,6,7,8-tetrahydrofolate + ATP + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24920", "l": "L-homoserine => 2-aminobut-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71032", "l": "L-cysteine(in) + L-phenylalanine(out) => L-cysteine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34508", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate => N,N-diacetyllegionaminate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66516", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655285", "l": "Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67567", "l": "3'-phosphoadenylyl sulfate + chenodeoxycholate <=> adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112152", "l": "RNA Polymerase III Promoter Opening at Type 3 Promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12554", "l": "(E)-pinosylvin + 4 CO2 + 4 CoA => (E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69005", "l": "Cdc6 protein is phosphorylated by CDK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30967", "l": "9,9',15-tri-cis-zeta-carotene = 9,9'-di-cis-zeta-carotene", "d": []}, {"i": "EC:5.2.1.12", "l": "\"zeta-carotene isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38869", "l": "pseudouridine(516) in 16S rRNA => uridine(516) in 16S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018467", "l": "formaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: formaldehyde + H2O + NAD+ = formate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38569", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32512", "l": "(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O => (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17462", "l": "D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388560", "l": "EDNRA,EDNRB bind EDNs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27815", "l": "acetate(in) + Na(+)(in) => acetate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28489", "l": "Fe(2+)(in) <=> Fe(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17551", "l": "1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine => 1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444100", "l": "PROT mediates L-proline uptake (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19634", "l": "(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) => (5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034820", "l": "4,9-DSHA hydrolase activity", "d": ["Catalysis of the reaction: (3E,1Z)-4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate + H2O = (2E,4E)-2-hydroxyhexa-2,4-dienoate + 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2514790", "l": "Elastin degradation by MMP14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797961", "l": "CHDH oxidises Cho to BETALD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508513", "l": "PTK2B binds JAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28207", "l": "2'-deoxyuridine + ATP => ADP + dUMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004087", "l": "carbamoyl-phosphate synthase (ammonia) activity", "d": ["Catalysis of the reaction: 2 ATP + hydrogencarbonate + NH4+ = 2 ADP + carbamoyl phosphate + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53270", "l": "L-xylulose => L-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57547", "l": "(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71924", "l": "2 Na(+)(out) + taurochenodeoxycholate(out) => 2 Na(+)(in) + taurochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671772", "l": "p-T38-PPP1R14A binds MLCP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56087", "l": "[Rab1 protein]-O-phosphocholine-L-serine + H2O <=> [Rab1 protein]-L-serine + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606839", "l": "Steryl sulfatase hydrolyses sulfate from steroid sulfates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114671", "l": "vWF binds to collagen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50433", "l": "AH2 + prostaglandin G1 => A + H2O + prostaglandin H1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45059", "l": "deoxynogalonate + O2 <=> H(+) + H2O + nogalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70573", "l": "argininosuccinate <=> fumarate + arginine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18484", "l": "cyclohexylsulfamate + H2O <=> cyclohexylamine + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170674", "l": "Dissociation of the Gi alpha:G olf complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54358", "l": "2-methylpropanal + CO2 => 3-methyl-2-oxobutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30843", "l": "H2O + N-formylmaleamate = formate + H(+) + maleamate", "d": []}, {"i": "EC:3.5.1.106", "l": "\"N-formylmaleamate deformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174224", "l": "Dissociation of Cdc20 from APC/C complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983707", "l": "SYK autophosphorylates at the activated BCR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52199", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.35", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984689", "l": "Kinesin-7 is a dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60711", "l": "(1R,3R)-chrysanthemal + H2O + NAD(+) <=> (1R,3R)-chrysanthemate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33207", "l": "ATP + H(+) + L-glutamate + NADPH = ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50150", "l": "a fatty acid + ethanol + H(+) => a fatty acid ethyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42576", "l": "2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O = 2-methylpropanoate + 2-oxopent-4-enoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37381", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28091", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010856", "l": "adenylate cyclase activator activity", "d": ["Binds to and increases the activity of adenylate cyclase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61330", "l": "3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + parthenolide + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15966", "l": "1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11295", "l": "2 H(+) + O2 + rifamycin B <=> H2O2 + rifamycin O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592316", "l": "Initial activation of proMMP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46227", "l": "(E)-feruloyl-CoA + H2O <=> (E)-ferulate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68356", "l": "H2O + N-acetyl-L-aspartyl-L-glutamate = L-glutamate + N-acetyl-L-aspartate", "d": []}, {"i": "EC:3.4.17.21", "l": "\"glutamate carboxypeptidase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38406", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214857", "l": "DL/DIF dimer binds to TUB and phosphorylated PLL in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871266", "l": "YAP1 binds TEAD3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6795667", "l": "MDM2 translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65588", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15395", "l": "meso-2,6-diaminoheptanedioate => (2S,6S)-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51853", "l": "(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66089", "l": "L-kynurenine + oxaloacetate => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12652", "l": "L-rhamnofuranose + NAD(+) <=> H(+) + L-rhamnono-1,4-lactone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16140", "l": "2'-deoxymugineate + NADP(+) <=> 3''-deamino-3''-oxonicotianamine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33362", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102652", "l": "gibberellin A9,2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A9 + 2-oxoglutarate + O2 <=> gibberellin A51 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61769", "l": "rebaudioside A + UDP-alpha-D-glucose => H(+) + rebaudioside D + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050296", "l": "stipitatonate decarboxylase activity", "d": ["Catalysis of the reaction: H2O + stipitatonate = CO2 + H+ + stipitatate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373732", "l": "Nephrin trans-homophilic interaction (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033771", "l": "licodione synthase activity", "d": ["Catalysis of the reaction: H+ + liquiritigenin + NADPH + O2 = H2O + licodione + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54481", "l": "1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57098", "l": "1-deoxy-D-xylulose 5-phosphate + A + methanethiol => AH2 + S-methyl-1-thio-D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21533", "l": "ATP + glutathione + glutathionylspermidine => ADP + H(+) + phosphate + trypanothione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69005", "l": "Cdc6 protein is phosphorylated by CDK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48254", "l": "ganglioside GD1b + H(+) + UDP => ganglioside GD2 + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12935", "l": "(S)-lactaldehyde + dihydroxyacetone phosphate => L-fuculose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.15.5", "l": "\"peptidyl-dipeptidase Dcp\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0090563", "l": "protein-phosphocysteine-sugar phosphotransferase activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + sugar(out) = protein cysteine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13909", "l": "phosphate + urate D-ribonucleoside = alpha-D-ribose 1-phosphate + urate", "d": []}, {"i": "EC:2.4.2.16", "l": "\"urate-ribonucleoside phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72923", "l": "O2 + proatranorin II + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46920", "l": "(E)-cinnamate + H(+) = CO2 + styrene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59913", "l": "(E)-4-hydroxynon-2-enal + H2O + NADP(+) => (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371527", "l": "HSF1 trimer translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75761", "l": "10-hydroxy-(11E)-octadecenoate => (9Z,11E)-octadecadienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783880", "l": "PIPOX oxidises PPCA to P6C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61463", "l": "a cytidine in RNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031868", "l": "prostaglandin F2-alpha receptor binding", "d": ["Binding to a prostaglandin F2-alpha receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45574", "l": "[alginate](n) => [(1->4)-beta-D-mannuronosyl](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69903", "l": "cytidine(out) + 2 Na(+)(out) = cytidine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022065", "l": "DSPGs are secreted (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38362", "l": "2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 <=> thiosulfate + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61535", "l": "ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218815", "l": "p-6Y-VEGFR2 binds NCK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73221", "l": "L-xylopyranose(in) + 2 Na(+)(in) => L-xylopyranose(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45436", "l": "H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38361", "l": "thiosulfate + ubiquinol-10 => 2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661625", "l": "FVIII is secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691174", "l": "RAC1 binds effectors at the ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56417", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate => alpha-D-glucose 1-phosphate + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28688", "l": "(S)-dihydroorotate + ubiquinone-8 => orotate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32368", "l": "4 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone => 4 Fe(II)-[cytochrome c] + 5 H(+) + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004787", "l": "thiamine diphosphate phosphatase activity", "d": ["Catalysis of the reaction: thiamine diphosphate + H2O = thiamine monophosphate + phosphate."]}, {"i": "RHEA:27998", "l": "H2O + thiamine diphosphate = H(+) + phosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050528", "l": "acyloxyacyl hydrolase activity", "d": ["Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34761", "l": "ADP + glycerol 2-phosphate(in) + H(+) + phosphate => ATP + glycerol 2-phosphate(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10503", "l": "butanoyl-CoA + glyoxylate + H2O <=> 3-ethylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5688797", "l": "ATXN3 family cleave Ub chains (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57181", "l": "L-lysyl-[protein] + methylglyoxal => N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11486", "l": "a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out) => a quinol + 2 Fe(III)-[cytochrome c](out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18216", "l": "alpha-D-glucose 1-phosphate + CTP + H(+) <=> CDP-D-glucose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27614", "l": "(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate = di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849878", "l": "PSD-95 binds NMDA receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679205", "l": "ULK1 phosphorylates Beclin-1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0015292", "l": "uniporter activity", "d": ["Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11729", "l": "cyclopentanol + NAD(+) => cyclopentanone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109700", "l": "AKT2 binds PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791066", "l": "Expression of HYOU1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2025890", "l": "Calcineurin binds NFATC1,2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45170", "l": "2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine => 2 (E)-sinapoyl-CoA + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689861", "l": "Recruitment of XPA and release of CAK  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45619", "l": "H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050190", "l": "phosphoglucokinase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = alpha-D-glucose 1,6-bisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18314", "l": "(R)-mandelonitrile => benzaldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668904", "l": "Formation of the CTF18 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33493", "l": "CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine => 2-hydroxyhexacosanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67742", "l": "aceneuramate => N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22044", "l": "ATP + H(+)(in) + H2O + K(+)(out) = ADP + 2 H(+)(out) + K(+)(in) + phosphate", "d": []}, {"i": "EC:7.2.2.19", "l": "\"H(+)/K(+)-exchanging ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50443", "l": "prostaglandin H1 <=> prostaglandin D1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62570", "l": "glycine + S-benzyl-L-cysteine => H2O + S-benzyl-L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73237", "l": "2-chloro-6-hydroxy-1,4-benzoquinone + chloride + 2 H(+) => 2,6-dichlorobenzoquinone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40922", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647980", "l": "mature RAS proteins translocate to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44429", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol => a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22443", "l": "UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25850", "l": "(S)-carvone + H(+) + NADH => (1S,5S)-carveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53598", "l": "1-octadecanoyl-sn-glycerol + phosphate => 1-octadecanoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65257", "l": "AH2 + O2 + verruculide C => A + H2O + verruculide C epoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685600", "l": "viral HA binds NCRI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396370", "l": "VTN binds collagens II, III and V (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35730", "l": "dodecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-dodecanoyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001587", "l": "Gq/11-coupled serotonin receptor activity", "d": ["Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799431", "l": "TP53 binds HIPK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29440", "l": "Fe(2+)(in) + H(+)(out) => Fe(2+)(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12106", "l": "7,8-dihydrofolate + dTMP => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686625", "l": "LAIR1 binds collagen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27394", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.330199557084356", "identifiers": [{"i": "GO:0016628", "l": "oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164056", "l": "Dephosphorylation of pChREBP (Ser 556) by PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75142", "l": "4-hydroxyprotoasukamycin + H(+) + NADH + O2 <=> asukamycin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64152", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21817", "l": "a D-alpha-amino acid + H2O + O2 => a 2-oxocarboxylate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762246", "l": "ANGPTL4 binds CDH11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44483", "l": "3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38400", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O => (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937613", "l": "CRHBP binds CRH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57619", "l": "dihydro-ML-236C-[compactin nonaketide synthase] + H2O <=> dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9612219", "l": "ERBB4s80 binds to SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706336", "l": "Active FLT3 binds to SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54029", "l": "a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419644", "l": "Transphosphorylation of pLIMK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52537", "l": "adenosine + dGTP => AMP + dGDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72841", "l": "ADP(in) + CoA(out) => ADP(out) + CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247843", "l": "secretion of WNT ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39967", "l": "2-aminobut-2-enoate = 2-iminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57333", "l": "H2O + 3 O2 + 3 propionate 3-nitronate => 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52950", "l": "deoxycholoyl-24-O-(beta-D-glucuronate) + UDP => deoxycholate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57427", "l": "guaiacol + O2 + reduced [NADH--hemoprotein reductase] <=> catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047060", "l": "(R)-pantolactone dehydrogenase (flavin) activity", "d": ["Catalysis of the reaction: (R)-pantolactone + A = 2-dehydropantolactone + AH(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44949", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O => 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9626928", "l": "CREBBP binds FOXO1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23706", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate => GTP + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75517", "l": "acetate + L-cysteine => H2O + N-acetyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18747", "l": "2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) => 2 juglone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16580", "l": "ADP + ATP + H(+) <=> P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16347", "l": "(3E,7E)-dolabella-3,7-dien-18-ol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33797", "l": "alpha-D-glucose + beta-D-fructose => H2O + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34744", "l": "15-methylhexadecasphinganine 1-phosphate => 13-methyltetradecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9718379", "l": "GNRHR binds chemical antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990055", "l": "phenylacetaldehyde synthase activity", "d": ["Catalyzes the reaction: L-phenylalanine + O2 + H2O -> phenylacetaldehyde + ammonia + hydrogen peroxide + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.10", "l": "\"dimethylglycine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69195", "l": "ATP + L-glutamate + L-glutamyl-[tubulin] <=> ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047819", "l": "D-glutamate(D-aspartate) oxidase activity", "d": ["Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2, and D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75238", "l": "TRAIL binds TRAIL receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2077421", "l": "FP-1039 acts as a ligand-trap for FGFR2b-binding ligands in endometrial cancer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70595", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008176", "l": "tRNA (guanine-N7-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9770119", "l": "Formation of the Spliceosomal E complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033741", "l": "adenylyl-sulfate reductase (glutathione) activity", "d": ["Catalysis of the reaction: AMP + glutathione disulfide + H+ + sulfite = 5'-adenylyl sulfate + 2 glutathione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802170", "l": "TP53 stimulates PLK3 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009485", "l": "IL34:CSF1 binds CSF1R (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65269", "l": "3-hydroxypentacecilide A + H(+) + NADPH + O2 => chrodrimanin F + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888589", "l": "Release of GABA at the synapse (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806394", "l": "TP53 and AP-1 stimulate MSH2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788622", "l": "p-Y-STATs dimerize (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67186", "l": "(glycyl)(n+1)-glycyl-L-glutamyl-[protein] + ADP + H(+) + phosphate => (glycyl)(n)-glycyl-L-glutamyl-[protein] + ATP + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35366", "l": "(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH <=> isopentadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854209", "l": "TBC1D10A binds JFC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006503", "l": "MECP2 binds the PVALB gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75939", "l": "4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23103", "l": "ATP + dAMP <=> ADP + dADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937807", "l": "SRC phosphorylates RUNX3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176318", "l": "Loading of claspin onto DNA during replication origin firing (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33606", "l": "H(+) + N-hexacosanoylsphinganine + NADPH + O2 <=> H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64174", "l": "galactarate => L-altrarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32726", "l": "L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791285", "l": "TP53 binds the BID gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417896", "l": "P2Y6 receptor can bind to UDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875816", "l": "STAT3 binds activated MET receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69841", "l": "(22S)-22-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051500", "l": "D-tyrosyl-tRNA(Tyr) deacylase activity", "d": ["Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14710", "l": "a 3-oxo-Delta(5)-steroid => a 3-oxo-Delta(4)-steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56974", "l": "(R)-methylmalonate semialdehyde + H(+) + NADH => (R)-3-hydroxy-2-methylpropanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13453", "l": "3'-phosphoadenylyl sulfate + quercetin = adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate", "d": []}, {"i": "EC:2.8.2.25", "l": "\"flavonol 3-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25830", "l": "A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O => AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5252133", "l": "ATP6AP1 binds V-ATPase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624272", "l": "MMPs cleave HB-EGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32481", "l": "3,5-diiodo-L-tyrosine + H(+) + 2 NADPH => 2 iodide + L-tyrosine + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69198", "l": "ADP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + H(+) + phosphate => ATP + L-glutamate + L-glutamyl-[beta-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451283", "l": "kainate receptor binds glutamate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25168", "l": "6-hydroxyhexan-6-olide = 6-oxohexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20589", "l": "glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134954", "l": "DHX9 binds DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70802", "l": "L-lysine(in) + L-ornithine(out) <=> L-lysine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607023", "l": "factor IXa associates with cell membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44308", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine = 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54353", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14950", "l": "A + H2O + quinoline-4-carboxylate => 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24018", "l": "CoA + vinorine => 16-epivellosimine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113402", "l": "Formation of DSIF:NELF:early elongation complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68920", "l": "ATP + H(+) + NADPH + pentanoate = AMP + diphosphate + NADP(+) + pentanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67075", "l": "a very long-chain fatty acyl-CoA + H2O <=> a very long-chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44961", "l": "(2E)-decenoyl-CoA + H(+) + NADPH => decanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990409", "l": "adrenomedullin binding", "d": ["Binding to adrenomedullin (AM)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23034", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate => 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036192", "l": "3-hydroxyindolin-2-one monooxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxyindolin-2-one + NAD(P)H + H+ + O2 = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13343", "l": "5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine => a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40649", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084505", "l": "Laminins bind HSPG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31676", "l": "NADP(+) + raucaffrinoline => H(+) + NADPH + perakine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685156", "l": "ATR phosphorylates RPA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17669", "l": "3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.4", "l": "\"melilotate 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50170", "l": "N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449829", "l": "IL11 binds IL11RA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804527", "l": "INTL1 binds bacterial glycans (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64885", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP => (6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45966", "l": "2 AMP + ATP + 2 H(+) => 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27637", "l": "5-dehydro-D-gluconate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70442", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2 <=> a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3215295", "l": "USP7 deubiquitinates MDM2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20032", "l": "10-deoxysarpagine + NADP(+) <=> H(+) + NADPH + vellosimine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362386", "l": "Glycosylation of Hh (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38626", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50217", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878117", "l": "RUNX3 binds ZFHX3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28256", "l": "(3Z)-hex-3-en-1-yl acetate + CoA => (3Z)-hex-3-en-1-ol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68752", "l": "alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429497", "l": "SLP-76 stimulates PLC gamma 2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190520", "l": "Association of Golgi  transport vesicles with microtubules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28078", "l": "2-hydroxyethylphosphonate + NAD(+) = H(+) + NADH + phosphonoacetaldehyde", "d": []}, {"i": "EC:1.1.1.309", "l": "\"phosphonoacetaldehyde reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52298", "l": "10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050310", "l": "sulfite dehydrogenase activity", "d": ["Catalysis of the reaction: sulfite + 2 ferricytochrome c + H2O = sulfate + 2 ferrocytochrome c."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22439", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29908", "l": "H2O + sn-glycero-3-phospho-(1'-rac-glycerol) => glycerol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73662", "l": "ADP(out) + ATP(in) + H(+)(out) + Mg(2+)(in) <=> ADP(in) + ATP(out) + H(+)(in) + Mg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0031784", "l": "melatonin receptor binding", "d": ["Binding to a melatonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.-.-", "l": "\"Intramolecular oxidoreductases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210294", "l": "Interaction of PECAM-1 and SHP-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56928", "l": "abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603467", "l": "Activated protein C is released from PROCR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681375", "l": "KIT binds ripretinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21599", "l": "L-serine + NADP(+) <=> 2-aminomalonate semialdehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20422", "l": "alpha-maltose 6'-phosphate + H2O => D-glucose + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332356", "l": "CAMK2 binds MAP3K7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432143", "l": "PECAM-1 binds PP2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186765", "l": "PLC-gamma binds to the active receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73015", "l": "D-leucine(in) = D-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34699", "l": "(2E,6E)-farnesyl diphosphate = (-)-alpha-isocomene + diphosphate", "d": []}, {"i": "EC:4.2.3.136", "l": "\"alpha-isocomene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16209", "l": "Co-precorrin-8X = cob(II)yrinate", "d": []}, {"i": "EC:5.4.99.60", "l": "\"cobalt-precorrin-8 methylmutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66832", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + preasperterpenoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55826", "l": "a bacteriochlorophyllide f + H2O => a 7(1),7(1)-dihydroxybacteriochlorophyllide d", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867041", "l": "EGFR phosphorylates EPS15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25986", "l": "(5R)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53291", "l": "3-dehydro-scyllo-inosose + H2O <=> 5-dehydro-L-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41442", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate => (2-aminoethyl)phosphonate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983309", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010329", "l": "auxin efflux transmembrane transporter activity", "d": ["Enables the transfer of auxin, from one side of a membrane to the other, out of a cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32027", "l": "(2E,6E)-farnesyl diphosphate = (-)-alpha-cuprenene + diphosphate", "d": []}, {"i": "EC:4.2.3.95", "l": "\"(-)-alpha-cuprenene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120023", "l": "somatostatin binding", "d": ["Binding to somatostatin, a polypeptide hormone involved in regulating pancreatic alpha and pancreatic beta cells and controlling growth hormone secretion as well as many other functions. Somatostatin is produced by several cell types including pancreatic delta cells. There are several different mature forms of somatostatin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034632", "l": "retinol transmembrane transporter activity", "d": ["Enables the transfer of retinol from one side of a membrane to the other. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5444523", "l": "Formation of MSH1:PMS2 Complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568740", "l": "AP-1 stimulates IL1A transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28975", "l": "H(+)(out) + L-asparagine(in) = H(+)(in) + L-asparagine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690669", "l": "CD22 binds itself to form homo-oligomers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2152276", "l": "Secretion of transmembrane collagens (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37056", "l": "3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate => 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66791", "l": "N-methyl-L-dopa + O2 <=> (3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71191", "l": "an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102998", "l": "4-sulfomuconolactone hydrolase activity", "d": ["Catalysis of the reaction: (5-oxo-2-sulfonato-2,5-dihydrofuran-2-yl)acetate + H2O <=> maleylacetate + sulfite + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11699", "l": "3'-demethylstaurosporine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + staurosporine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805470", "l": "AMPK phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19092", "l": "S-adenosyl-L-methionine + uroporphyrinogen III <=> H(+) + precorrin-1 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005519", "l": "cytoskeletal regulatory protein binding", "d": ["Binding to a protein involved in modulating the reorganization of the cytoskeleton."]}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0031559", "l": "oxidosqualene cyclase activity", "d": ["Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008266", "l": "poly(U) RNA binding", "d": ["Binding to a sequence of uracil residues in an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17605", "l": "ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine = ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.25", "l": "\"tubulin--tyrosine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8948136", "l": "ULK1 Translocates to the mitochondria (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10931", "l": "ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014467", "l": "RHOG binds effectors at the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54715", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16504", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol <=> H(+) + myo-inositol + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62868", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2 = H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212380", "l": "Formation of TRAP coactivator complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72642", "l": "1,6-dihydroxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine <=> 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678998", "l": "Endosomal TLRs pass through the Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839746", "l": "Truncated AMER1 mutants destabilize the destruction complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42748", "l": "cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.176", "l": "\"16S rRNA (cytosine(967)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43493", "l": "7(1)-hydroxychlorophyll a + NADP(+) => chlorophyll b + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38082", "l": "2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA <=> 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875443", "l": "USP8 deubiquitinates LRIG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34359", "l": "a 1,2-diacylglycerol + H2O = a 2-acylglycerol + a carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71918", "l": "2 Na(+)(out) + tauronorcholate(out) <=> 2 Na(+)(in) + tauronorcholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627078", "l": "XIAP binds CASP9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75700", "l": "2 glutathione + NAD(+) => glutathione disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102758", "l": "very-long-chain enoyl-CoA reductase activity", "d": ["Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + NADP+ = a very-long-chain (2E)-enoyl-CoA + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61825", "l": "pregnenolone + UDP-alpha-D-glucose => H(+) + pregnenolone 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9704248", "l": "CHRM4 binds CHRM4 antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32905", "l": "calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => calciol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17061", "l": "H(+) + NADPH + O2 + phenol = catechol + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.7", "l": "\"phenol 2-monooxygenase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33117", "l": "malonate(out) => malonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9761421", "l": "CDH11 associates with catenins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51001", "l": "[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine => [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851908", "l": "Activated MET binds GAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159796", "l": "Furin cleaves pro-factor IX to factor IX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28558", "l": "D-fructose 6-phosphate + H2O = D-fructose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.071082486141265", "identifiers": [{"i": "GO:0008094", "l": "ATP-dependent activity, acting on DNA", "d": ["Catalytic activity that acts to modify DNA, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13691", "l": "glycerol 1-phosphate + H(+) + phosphate => diphosphate + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68177", "l": "2-oxoglutarate + N-geranyl-L-glutamate + O2 => CO2 + dainate A + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56113", "l": "2-all-trans-nonaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71749", "l": "2-oxoglutarate(in) + L-2-aminoadipate(out) => 2-oxoglutarate(out) + L-2-aminoadipate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46490", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417896", "l": "P2Y6 receptor can bind to UDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199298", "l": "AKT phosphorylates CREB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23087", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA <=> 7-methyl-3-oxooct-6-enoyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74149", "l": "benzoyl-CoA + succinyl-CoA => (S)-2-benzoylsuccinyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947535", "l": "Cyclisation of GTP to precursor Z (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61419", "l": "(S)-8-oxocitronellyl enol <=> cis-trans-nepetalactol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051008", "l": "Hsp27 protein binding", "d": ["Binding to Hsp27 proteins, a lightweight heat shock protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201637", "l": "Caspase-mediated cleavage of plectin-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68987", "l": "a 2'-deoxycytidine in DNA + ATP + H2O + S-adenosyl-L-methionine <=> a 5-methyl-2'-deoxycytidine in DNA + ADP + 2 H(+) + phosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71181", "l": "L-histidine(in) + L-tryptophan(out) => L-histidine(out) + L-tryptophan(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40106", "l": "H2O + propanoyl-CoA <=> CoA + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877361", "l": "Pyrin binds ASC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624120", "l": "CEBPA binds CDK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167419", "l": "The receptor:G-protein complex releases GDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31900", "l": "indole + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047165", "l": "flavonol-3-O-beta-glucoside O-malonyltransferase activity", "d": ["Catalysis of the reaction: flavonol 3-O-beta-D-glucoside + malonyl-CoA = malonyl-flavonol 3-O-beta-D-glucoside + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800870", "l": "NDUF subunits bind to form the FP subcomplex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25071", "l": "3-hydroxybenzoate + ATP + CoA => 3-hydroxybenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70365", "l": "1-carboxybiuret + H(+) => cyanurate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45459", "l": "H2O + N-dodecanoylethanolamine <=> dodecanoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0005160", "l": "transforming growth factor beta receptor binding", "d": ["Binding to a transforming growth factor beta receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701534", "l": "p-Y705, S727 STAT3 dimer binds HIF1A gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191402", "l": "Reduction of presqualene diphosphate to form squalene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15648", "l": "16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] <=> 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858500", "l": "CLEC10A binds Tn-MUC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39434", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40732", "l": "(20S)-ginsenoside Rg3 + 2 H2O => (20S)-protopanaxadiol + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22589", "l": "4-aminobutanal => 1-pyrroline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32567", "l": "(2E)-geranyl diphosphate = (1R,4S)-camphene + diphosphate", "d": []}, {"i": "EC:4.2.3.116", "l": "\"(+)-camphene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39636", "l": "3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38317", "l": "3-hydroxybenzoate + pyruvate => chorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38011", "l": "chlorophyll a + H2O = chlorophyllide a + H(+) + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28250", "l": "acetyl-CoA + H(+) + malonyl-CoA = acetoacetyl-CoA + CO2 + CoA", "d": []}, {"i": "EC:2.3.1.194", "l": "\"acetoacetyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161293", "l": "Tropoelastin forms aggregate globules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23478", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O => 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430308", "l": "PARVB interacts with Alpha-actinin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031433", "l": "telethonin binding", "d": ["Binding to telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5695964", "l": "ABHD14B hydrolyses PNPB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18841", "l": "(R)-glycerate + NADP(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35166", "l": "H(+)(out) + minocycline(in) <=> H(+)(in) + minocycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.74", "l": "\"deoxycytidine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46577", "l": "H(+) + NADPH + O2 + sitosterol => 2 H2O + NADP(+) + stigmasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44190", "l": "1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254291", "l": "ERBB4s80 binds STAT5A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35567", "l": "H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine = (9Z,12Z)-octadecadienoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73692", "l": "3'-AMP(out) + phosphate(in) => 3'-AMP(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18270", "l": "ethyl (S)-3-hydroxyhexanoate + NADP(+) => ethyl 3-oxohexanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034809", "l": "benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene-cis-4,5-dihydrodiol = 4,5-dihydroxybenzo(a)pyrene + H2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30858", "l": "dammarenediol-II <=> (S)-2,3-epoxysqualene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042614", "l": "CD70 receptor binding", "d": ["Binding to a CD70, a receptor found on the surface of most activated B cells and some activated T cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811508", "l": "ING2-bound EP300 acetylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73429", "l": "H2O + oxidized [NADPH--hemoprotein reductase] + scutellarein 7-methyl ether => genkwanin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16259", "l": "alpha-D-glucose + alpha-D-glucose 1-phosphate => alpha,alpha-trehalose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21364", "l": "H2O + N-(6-aminohexanoyl)-6-aminohexanoate = 2 6-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450348", "l": "Activated human JNKs migrate to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16011", "l": "ADP + formyl phosphate => ATP + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5688797", "l": "ATXN3 family cleave Ub chains (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140800", "l": "gamma-aminobutyric acid:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4-aminobutanoate(out) + H+(in) = 4-aminobutanoate(in) + H+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40389", "l": "1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30044", "l": "fumarate + L-aspartate => iminosuccinate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047260", "l": "alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity", "d": ["Catalysis of the reaction: GDP-D-glucose + glucose-6-phosphate = alpha,alpha-trehalose 6-phosphate + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093331", "l": "Ras:GTP binds p120-RasGAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102605", "l": "cyclooctat-9-en-5,7-diol C18-monooxygenase activity", "d": ["Catalysis of the reaction: cyclooctat-9-en-5,7-diol + O2 + NADPH + H+ <=> cyclooctatin + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24502", "l": "ATP + H(+) + phosphate => adenosine 5'-tetraphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018591", "l": "methyl tertiary butyl ether 3-monooxygenase activity", "d": ["Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50682", "l": "N-terminal L-glutamyl-[protein] + NH4(+) => H2O + N-terminal L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799199", "l": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.21", "l": "\"squalene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39681", "l": "3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA => (11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13222", "l": "(R)-mevalonate + NAD(+) => H(+) + mevaldate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44112", "l": "hexadecanoyl-CoA + nonan-1-ol = CoA + nonyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35243", "l": "ADP + H(+) + thiamine diphosphate = adenosine thiamine triphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52009", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66117", "l": "2-oxobutanoate + L-glutamine => (2S)-2-aminobutanoate + 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9815510", "l": "MIB2 binds CYLD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17478", "l": "precorrin-6B + 2 S-adenosyl-L-methionine => CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48944", "l": "ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = 3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35148", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36800", "l": "a ribonucleoside 5'-diphosphate + H2O => a ribonucleoside 5'-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.217", "l": "\"3-dehydrotetronate 4-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939900", "l": "RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31456", "l": "NAD(+) + reduced riboflavin => 2 H(+) + NADH + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53228", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68667", "l": "17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428609", "l": "Type I Na+-coupled phosphate co-transport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12215", "l": "9H-fluoren-9-ol + NADP(+) <=> 9H-fluoren-9-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41896", "l": "(2E)-tetradecenoyl-[ACP] + H(+) + NADPH = NADP(+) + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17109", "l": "FMNH2 + N-methylnicotinate + O2 = (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55782", "l": "all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP => all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63428", "l": "ATP + H2O + levoglucosan = ADP + D-glucose 6-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.232", "l": "\"levoglucosan kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74712", "l": "Dissociation of IRS-P from insulin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856945", "l": "PP2A methylation by LCMT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61970", "l": "a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0140659", "l": "cytoskeletal motor regulator activity", "d": ["Binds to and modulates the activity of a motor protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57056", "l": "D-apiofuranose + NAD(+) = D-apionolactone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.420", "l": "\"D-apiose dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14419", "l": "H(+) + N(6)-acetyl-L-lysine + phosphate => acetyl phosphate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54902", "l": "hexadecanoyl-[ACP] + NAD(+) => (2E)-hexadecenoyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645672", "l": "p14ARF translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21348", "l": "8 H(+) + 10 malonyl-CoA = 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2", "d": []}, {"i": "EC:2.3.1.235", "l": "\"tetracenomycin F2 synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62721", "l": "3 H(+) + 3 NADPH + 3 O2 + probetaenone I => betaenone B + 3 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35854", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202203", "l": "Recruitment of PI3K to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033276", "l": "NTRK2 binds TIAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46912", "l": "H2O + juvenile hormone III = H(+) + juvenile hormone III carboxylate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45180", "l": "2 (E)-4-coumaroyl-CoA + spermidine = 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine", "d": []}, {"i": "EC:2.3.1.249", "l": "\"spermidine dicoumaroyl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24030", "l": "carnitine + CO2 + succinate => 2-oxoglutarate + 4-(trimethylamino)butanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141439", "l": "Release of activated MAD2 from kinetochores (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5658435", "l": "RAS GAPs bind RAS:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73064", "l": "H(+)(out) + Mn(2+)(in) => H(+)(in) + Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32146", "l": "L-arginine(in) <=> L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64884", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP = (6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170846", "l": "TGFBR2 recruits TGFBR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391168", "l": "SIRP gamma binds CD47 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2167942", "l": "Collagen type XIII ectodomain shedding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679045", "l": "C-ter TLR9 dimer binds HCQ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2530429", "l": "Formation of soluble VTN:C5b-C9  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429449", "l": "Syk activation leads to SLP-76 activation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33676", "l": "H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) => H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174171", "l": "Association of Cyclin A with the APC/C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043532", "l": "angiostatin binding", "d": ["Binding to angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59497", "l": "(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160935", "l": "SMURF1 ubiquitinates RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36791", "l": "H2O + N(omega)-hydroxy-L-arginine = hydroxyurea + L-ornithine", "d": []}, {"i": "EC:3.5.3.25", "l": "\"N(omega)-hydroxy-L-arginine amidinohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35179", "l": "6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA = 7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone", "d": []}, {"i": "EC:2.3.1.221", "l": "\"noranthrone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31296", "l": "(2E)-2-hydroxypenta-2,4-dienoate => 2-oxopent-4-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30470", "l": "(2Z,6Z)-farnesyl diphosphate <=> (+)-endo-beta-bergamotene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41565", "l": "aklavinone + dTDP-beta-L-rhodosamine => aclacinomycin T + dTDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22296", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate = (1R,2R,3R)-prephytoene diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50993", "l": "thromboxane B2(out) => thromboxane B2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34582", "l": "2 2-oxoglutarate + 2 O2 + pentalenolactone D <=> 2 CO2 + H2O + pentalenolactone F + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759513", "l": "CDH11 canonical mRNA is translated into CDH11 canonical protein isoform (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56699", "l": "D-ribulose 5-phosphate + L-tryptophan <=> (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39929", "l": "1-O-alkyl-sn-glycero-3-phosphate + choline + H(+) => 1-O-alkyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17014", "l": "H(+) + phosphoenolpyruvate => 3-phosphonopyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377640", "l": "Autophosphorylation of SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32852", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74448", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204798", "l": "Interaction of Tie2 and p85 of PI3K (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130194", "l": "ABL phosphorylates WAVEs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428273", "l": "SPHK1 phosphorylates SPG to S1P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74583", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-glutamyl-[protein] = N-acetyl-L-cysteine + N-terminal L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23031", "l": "malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein] <=> acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928614", "l": "EFNB:GRB4 binds GIT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018730", "l": "glutaconate CoA-transferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603419", "l": "Activated NTRK3 binds SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804100", "l": "HMGB1 binds LPS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23533", "l": "ATP + cholate + CoA => AMP + choloyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913371", "l": "GM-CSF receptor alpha:GM-CSF binds Bc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15731", "l": "H(+) + keto-D-fructuronate + NADH => D-mannonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33415", "l": "bornane-2,6-dione + H2O = [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)", "d": []}, {"i": "EC:3.7.1.18", "l": "\"6-oxocamphor hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22763", "l": "Cypridina luciferin + O2 <=> CO2 + hnu + oxidized Cypridina luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14405", "l": "D-glucose + NADP(+) = D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75349", "l": "thiocyanate(out) => thiocyanate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12238", "l": "6-hydroxynicotinate + H(+) + NADPH => H2O + NADP(+) + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56253", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57748", "l": "2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH = C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193641", "l": "IKK-beta is recruited (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658435", "l": "RAS GAPs bind RAS:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29480", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-epicubenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102575", "l": "3-oxo-dodecanoyl-ACP hydrolase activity", "d": ["Catalysis of the reaction: H2O + a 3-oxo-dodecanoyl-[acp] = 3-oxododecanoate + H+ + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18848", "l": "(R)-glycerate + NAD(+) <=> 2-hydroxy-3-oxopropanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49629", "l": "acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine => 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.141", "l": "\"4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005369", "l": "taurine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635861", "l": "NUMB:ITCH binds GLI1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18504", "l": "ergosterol + NADP(+) <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072547", "l": "tricoumaroylspermidine meta-hydroxylase activity", "d": ["Catalysis of the reaction: tricoumaroyl spermidine + NADPH + O2 = dicoumaroyl monocaffeoyl spermidine + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62440", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) = 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1)", "d": []}, {"i": "EC:4.2.2.27", "l": "\"pectin monosaccharide-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57222", "l": "N(2)-(1-hydroxy-2-oxopropyl)-GTP => GTP + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607736", "l": "MALT1 oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71640", "l": "K(+)(in) + Na(+)(in) => K(+)(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45734", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate => D-ribulose 5-phosphate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848829", "l": "CBL autoubiquitinates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033929", "l": "blood-group-substance endo-1,4-beta-galactosidase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in blood group A and B substances."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73829", "l": "an alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697084", "l": "Defective rpoB in Mtb RNAP transcribes RNA polyanion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46939", "l": "(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) <=> ATP + H(+) + L-2-aminoadipate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676589", "l": "RANKL,sRANKL trimer binds RANK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806732", "l": "GNLY binds the bacterial cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59643", "l": "D-xylotetraose + O2 <=> D-xylotetraono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035976", "l": "Defective HEXA does not cleave the terminall GalNAc from small HA fragments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19298", "l": "ATP + beta-alanine + L-histidine => ADP + carnosine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18940", "l": "an N-acyl-L-homoserine lactone + H2O <=> a carboxylate + L-homoserine lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665411", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65812", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2 = A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA", "d": []}, {"i": "EC:1.14.99.69", "l": "\"tRNA 2-(methylsulfanyl)-N(6)-isopentenyladenosine(37) hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63451", "l": "(2-aminoethyl)phosphonate + CTP <=> CMP-(2-aminoethyl)phosphonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66893", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21552", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70444", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + O2 => a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65994", "l": "5,6-trans-vitamin D3 => calciol + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45220", "l": "coenzyme M + methyl-Co(III)-[trimethylamine-specific corrinoid protein] = Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49319", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33248", "l": "O2 + putrescine => 1-pyrroline + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14600", "l": "a CDP-1,2-diacyl-sn-glycerol + choline <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047276", "l": "N-acetyllactosaminide 3-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP-galactose = alpha-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445064", "l": "Activation of Rac1 by VAV2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20237", "l": "(1S,4S)-5-oxo-1,2-campholide = [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674093", "l": "PDGFRs bind type I TKI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.198", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12621", "l": "H(+) + L-aspartate = CO2 + L-alanine", "d": []}, {"i": "EC:4.1.1.12", "l": "\"aspartate 4-decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53037", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592436", "l": "Initial activation of proMMP9 by MMPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61712", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine = 2 Fe(III)-[cytochrome b5] + H2O + N(delta)-methyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45875", "l": "15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32589", "l": "(3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => (1R,4R)-dihydrocarvone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72597", "l": "H(+)(in) + N-acetyl-L-aspartyl-L-glutamate(in) => H(+)(out) + N-acetyl-L-aspartyl-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48650", "l": "20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426032", "l": "DAG is metabolized by DAGL to 2-AG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018478", "l": "malonate-semialdehyde dehydrogenase (acetylating) activity", "d": ["Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0140487", "l": "metal ion sequestering activity", "d": ["Binding to a metal ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74221", "l": "L-serine + tRNA(Thr) => H2O + L-seryl-tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45794", "l": "[ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [ribosomal protein S23]-L-proline + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0031846", "l": "neurotensin receptor binding", "d": ["Binding to a neurotensin receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0010242", "l": "oxygen evolving activity", "d": ["Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32022", "l": "(2E,6E)-farnesyl diphosphate <=> beta-cubebene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35181", "l": "7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone => 6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31484", "l": "soyasapogenol E + UDP-alpha-D-glucuronate => H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13417", "l": "5,12-dihydroxanthommatin + NAD(+) = H(+) + NADH + xanthommatin", "d": []}, {"i": "EC:1.3.1.41", "l": "\"xanthommatin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19565", "l": "(2E)-geranyl diphosphate + H2O = diphosphate + sabinene hydrate", "d": []}, {"i": "EC:4.2.3.11", "l": "\"sabinene-hydrate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25408", "l": "ADP-alpha-D-glucose + D-glucose = ADP + alpha,alpha-trehalose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222020", "l": "NUAK1 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56016", "l": "H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5632652", "l": "Hh-Npp binds CDON and PTCH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13364", "l": "CTP + H(+) + sn-glycerol 3-phosphate <=> CDP-glycerol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.10", "l": "\"tripeptidyl-peptidase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41783", "l": "beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38647", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13806", "l": "A + a 3-oxo-5alpha-steroid => a 3-oxo-Delta(4)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52194", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39619", "l": "(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH = (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54717", "l": "N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035439", "l": "halimadienyl-diphosphate synthase activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate = halima-5(6),13-dien-15-yl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097005", "l": "adipokinetic hormone receptor binding", "d": ["Binding to an adipokinetic hormone receptor. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10227", "l": "ATP + pyridoxal <=> ADP + H(+) + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52664", "l": "a short-chain (3S)-3-hydroxyacyl-CoA = a short-chain (2E)-enoyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.150", "l": "\"short-chain-enoyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318571", "l": "Defective MMADHC does not bind MMACHC:B12r (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199935", "l": "MSK1 activates CREB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912734", "l": "CBL:CRKL binds RAPGEF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42860", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33734", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11649", "l": "(-)-menthol + H(+) + NADPH + O2 => 1,4-menthane-3,8-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71850", "l": "glycoursodeoxycholate(out) <=> glycoursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65264", "l": "3-hydroxypentacecilide A + A = AH2 + chrodrimanin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868236", "l": "BAR domain proteins recruit dynamin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026464", "l": "BDNF-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62729", "l": "(+)-malbrancheamide B + bromide + FAD + 2 H(+) => (+)-malbrancheamide D + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52837", "l": "H(+) + indole + NADH + O2 => H2O + indoxyl + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190245", "l": "FGFR1b binds to FGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618328", "l": "ATAT acetylates microtubules (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102991", "l": "myristoyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: myristoyl-CoA + H2O <=> H+ + tetradecanoate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005147", "l": "oncostatin-M receptor binding", "d": ["Binding to an oncostatin-M receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75932", "l": "H2O + taurocyamine => taurine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381727", "l": "RAP1A exchanges GDP for GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046608", "l": "carotenoid isomerase activity", "d": ["Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26125", "l": "FAD + L-proline => (S)-1-pyrroline-5-carboxylate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990841", "l": "promoter-specific chromatin binding", "d": ["Binding to a section of chromatin that is associated with gene promoter sequences of DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38302", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA <=> 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008036", "l": "diuretic hormone receptor activity", "d": ["Combining with a diuretic hormone and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52070", "l": "(9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+) => 9-(9Z-hexadecenoyloxy)-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809680", "l": "MTMR12 binds MTM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0016737", "l": "oxidoreductase activity, acting on reduced flavodoxin as donor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}, {"i": "EC:1.19.-.-", "l": "\"Acting on reduced flavodoxin as donor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849882", "l": "SALMs 1-4 bind reticulon 3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60442", "l": "acetate + H(+) + methanol => H2O + methyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68696", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72544", "l": "2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out) => 2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37560", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351207", "l": "Spermine  => N-acetylated spermine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38460", "l": "2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA => 2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20298", "l": "an anilide + H2O => a carboxylate + aniline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654623", "l": "Activated FGFR3 binds FRS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61810", "l": "AMP + H(+) + L-alanyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-alanyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033266", "l": "ABC-type choline transporter activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of choline across a membrane."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102352", "l": "phosphatidate kinase activity", "d": ["Catalysis of the reaction: ATP + a 1,2-diacyl-sn-glycerol 3-phosphate = ADP + a 1,2-diacyl-sn-glycerol 3-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75428", "l": "eburicol + O2 + reduced [NADPH--hemoprotein reductase] => 32-hydroxyeburicol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201629", "l": "Caspase-mediated cleavage of Tau (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44346", "l": "ADP + dapdiamide A + H(+) + phosphate => ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34398", "l": "L-phenylalanine <=> L-beta-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21885", "l": "H2O + trithionate => H(+) + sulfate + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416929", "l": "PTGFR binds PGF2a (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30318", "l": "1,7-dimethylxanthine + H(+) + NADH + O2 <=> 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43757", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39894", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine <=> dTDP + H(+) + vancomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102209", "l": "trans-permethrin hydrolase activity", "d": ["Catalysis of the reaction: (-)-trans-permethrin + H2O <=> H+ + (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28686", "l": "L-aspartate + ubiquinone-8 <=> iminosuccinate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003849", "l": "3-deoxy-7-phosphoheptulonate synthase activity", "d": ["Catalysis of the reaction: D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45982", "l": "9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+) => 3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71069", "l": "L-arginine(out) + L-phenylalanine(in) => L-arginine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56326", "l": "2'-deoxyribonucleotide-DNA + H(+) + S-methyl-L-cysteinyl-[protein] => (2'-deoxyribonucleoside 5'-methylphosphotriester)-DNA + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60100", "l": "cyanidin + UDP-alpha-D-glucose = cyanidin 3-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16121", "l": "5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10262", "l": "ADP + H(+) + Mg(2+)(in) + phosphate => ATP + H2O + Mg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36997", "l": "3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA => (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70356", "l": "1-carboxybiuret + H(+) => biuret + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814387", "l": "CASP14 cleaves filaggrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033479", "l": "Dimerization of FGFR2 point mutants with enhanced kinase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879327", "l": "acetylglucosamine-inositol is deacetylated by Mca (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354097", "l": "Activation of Talin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008568", "l": "microtubule severing ATPase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789092", "l": "NOX2 generates superoxide anion from oxygen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004479", "l": "methionyl-tRNA formyltransferase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44651", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111237", "l": "Formation of ADAR1 homodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019977", "l": "interleukin-21 binding", "d": ["Binding to interleukin-21."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65110", "l": "aculene A + holo-[peptidyl-carrier protein] => aculene C + L-prolyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50141", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.-", "l": "\"Transferring other groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42851", "l": "8-demethyltetracenomycin C + dTDP-beta-L-rhamnose <=> 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45749", "l": "(3Z)-hexenoyl-CoA => (2E)-hexenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14308", "l": "ATP + L-proline + tRNA(Pro) <=> AMP + diphosphate + L-prolyl-tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60246", "l": "2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3] => 2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450027", "l": "Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043871", "l": "delta1-piperideine-6-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: delta1-piperideine-6-carboxylate + NAD+ + 2 H2O = 2-aminoadipate + NADH + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168849", "l": "tBID binds to inactive BAX protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016034", "l": "maleylacetoacetate isomerase activity", "d": ["Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141000", "l": "histone H4K91 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 4 at the lysine-91 residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53068", "l": "4-methoxyestrone + UDP-alpha-D-glucuronate = 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32325", "l": "ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.197", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17640", "l": "squalene <=> hop-22(29)-ene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017051", "l": "retinol dehydratase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807144", "l": "HTN1,HTN3 or HTN5 binds the bacterial anionic surface  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004422", "l": "hypoxanthine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0046557", "l": "glucan endo-1,6-beta-glucosidase activity", "d": ["Catalysis of the random hydrolysis of (1->6) linkages in (1->6)-beta-D-glucans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668714", "l": "RAC1:GTP binds NOX1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805981", "l": "HMGB1 release from cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354077", "l": "Integrin alphaIIb beta3 activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33555", "l": "an N-acyl-(4R)-4-hydroxysphinganine + H2O = (4R)-hydroxysphinganine + a fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54182", "l": "a long-chain fatty acyl-[ACP] + H(+) + NADH => a long-chain fatty aldehyde + holo-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176445", "l": "SMURF2 binds SMAD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25961", "l": "benzoin + NADP(+) => benzil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30842", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-talose <=> UDP-N-acetyl-beta-L-fucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047286", "l": "NAD+-diphthamide ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: peptide diphthamide + NAD+ = peptide N-(ADP-D-ribosyl)diphthamide + niacinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12999", "l": "2-O-[(E)-feruloyl]-D-galactarate + CoA => (E)-feruloyl-CoA + galactarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34003", "l": "5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 = 7-dehydrodesmosterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23857", "l": "H(+) + Hg + NADP(+) => Hg(2+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428917", "l": "G13 activation by TP receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944246", "l": "Association of procollagen type XXI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72879", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate = NH4(+) + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60699", "l": "(R)-lavandulyl diphosphate + H2O <=> (R)-lavandulol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753634", "l": "GGT dimers hydrolyse APAP-SG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30623", "l": "A + all-trans-neurosporene = AH2 + all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857686", "l": "FITM1, FITM2 bind TAGs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9727349", "l": "XDH dehydrogenates xanthine to form urate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10539", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O <=> 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61218", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69810", "l": "benzoyl-AMP + CoA <=> AMP + benzoyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0031690", "l": "adrenergic receptor binding", "d": ["Binding to an adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202164", "l": "Translocation of PDK1 to Plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55606", "l": "a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47448", "l": "(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54866", "l": "4-methylpent-3-en-1-yl acetate + H2O + NADP(+) => H(+) + NADPH + O2 + sulcatone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429529", "l": "Thrombin binding to GP1b:IX:V (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16298", "l": "5alpha-androstane-3beta,17beta-diol + NADP(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32339", "l": "(+)-thujan-3-ol + NADP(+) = (+)-thujan-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003835", "l": "beta-galactoside alpha-2,6-sialyltransferase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactoside = N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34474", "l": "NAD(+) + propanoyl-CoA <=> acryloyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28005", "l": "beta-D-fructose 6-phosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69296", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate = 3-hydroxypent-4-ene nitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700175", "l": "Active ALK phosphorylates SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72791", "l": "bilirubin-glucuronoside(out) = bilirubin-glucuronoside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050598", "l": "taxane 13-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + taxa-4(20),11-dien-5alpha-ol = H2O + NADP+ + taxa-4(20),11-dien-5alpha,13alpha-diol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034933", "l": "1-hydroxy-6-methoxypyrene methyltransferase activity", "d": ["Catalysis of the reaction: 1-hydroxy-6-methoxypyrene + XCH3 = 1,6-dimethoxypyrene + HX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617859", "l": "Retinoic acid activates HOXB4 chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602458", "l": "Activation of proMMP10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961888", "l": "E2F1 binds the CCNA1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54970", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + phosphate => hexadecanoyl phosphate + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37049", "l": "H(+)(in) + L-histidine(in) => H(+)(out) + L-histidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443779", "l": "Linkage of L1 with treadmilling F-actin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64611", "l": "L-threonyl-[protein] + UTP <=> diphosphate + uridylyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73800", "l": "SAICAR => AICAR + Fumarate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46836", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3149519", "l": "MMACHC decyanates CNCbl (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10324", "l": "an L-glycol + NADP(+) = a 2-hydroxycarbonyl + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043836", "l": "xanthine hydrolase activity", "d": ["Catalysis of the reaction: xanthine + H2O = 4-ureido-5-imidazole carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34310", "l": "4-nitrocatechol + NADPH + O2 <=> 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42417", "l": "a ubiquinone + L-proline => (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156930", "l": "GTP-binding activates eEF2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2509831", "l": "ITPA hydrolyses XTP to XMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48042", "l": "globoside Gb3Cer + N-acetyl-beta-D-galactosamine => globoside Gb4Cer + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0061651", "l": "Atg12 conjugating enzyme activity", "d": ["Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y = Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990931", "l": "mRNA N6-methyladenosine dioxygenase activity", "d": ["Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693198", "l": "RHOD binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109858", "l": "MAP2K2 binds MAPK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30535", "l": "biotinate sulfoxide + H(+) + NADPH = biotin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73144", "l": "CoA(out) + FAD(in) => CoA(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39018", "l": "22-oxodocosanoate + H2O + NAD(+) <=> docosanedioate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080059", "l": "flavonol 3-O-arabinosyltransferase activity", "d": ["Catalysis of the reaction: UDP-arabinose + a flavonol = UDP + a flavonol 3-O-D-arabinoside."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033787", "l": "cyanocobalamin reductase (cyanide-eliminating) activity", "d": ["Catalysis of the reaction: cob(I)alamin + hydrogen cyanide + NADP+ = cyanocob(III)alamin + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5615668", "l": "AKR1C3 reduces atRAL to atROL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52662", "l": "AMP + an L-alpha-aminoacyl-[ACP] + diphosphate => an L-alpha-amino acid + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14126", "l": "2 raffinose => 1(F)-alpha-D-galactosylraffinose + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47155", "l": "2,5-dioxopentanoate + H2O + NAD(+) <=> 2-oxoglutarate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57368", "l": "H2O + NADPH = (6R)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24372", "l": "H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] = H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine", "d": []}, {"i": "EC:3.1.4.45", "l": "\"N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22351", "l": "4-aminoimidazole + H(+) + H2O <=> imidazol-4-one + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57823", "l": "[phosphate](n) + ADP <=> [phosphate](n+1) + AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047435", "l": "5-guanidino-2-oxopentanoate decarboxylase activity", "d": ["Catalysis of the reaction: 5-guanidino-2-oxopentanoate + H+ = 4-guanidinobutanal + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046904", "l": "calcium oxalate binding", "d": ["Binding to calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68650", "l": "H(+) + hydrogen sulfide + L-lanthionine => 2 L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58377", "l": "decan-1-ol + NADP(+) => decanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13014", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11502", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate => 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60374", "l": "D-fructose(in) => D-fructose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-377640", "l": "Autophosphorylation of SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244500", "l": "botE:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868622", "l": "Glucose is transferred from UDP-glucose onto glucose-6-phosphate (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54291", "l": "ATP + L-tyrosyl-[protein] <=> diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483174", "l": "PE is methylated to PC by PEMT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11040", "l": "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O", "d": []}, {"i": "EC:4.2.1.19", "l": "\"imidazoleglycerol-phosphate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.905555711669919", "identifiers": [{"i": "GO:0004527", "l": "exonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2564826", "l": "4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56349", "l": "4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 => 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42963", "l": "H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain] <=> NADH + 2 oxidized [nitric oxide reductase rubredoxin domain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950504", "l": "IL27 binds CRLF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-532549", "l": "MPI isomerises Fru6P to Man6P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68332", "l": "(R)-4'-phosphopantothenate + H2O = (R)-pantothenate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374663", "l": "DCC interaction with Ezrin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63182", "l": "H(+) + NADP(+) + 2 superoxide => NADPH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12041", "l": "(S)-3-(imidazol-5-yl)lactate + NADP(+) => 3-(imidazol-5-yl)pyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72621", "l": "Ribosomal scanning  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374663", "l": "DCC interaction with Ezrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73862", "l": "1-methylnicotinamide(out) <=> 1-methylnicotinamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030378", "l": "serine racemase activity", "d": ["Catalysis of the synthesis of free D-serine from L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404135", "l": "RBP4 binds atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37004", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196017", "l": "Dynamin is recruited to the gap junction plaque (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12015", "l": "ATP + thiamine <=> ADP + H(+) + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675194", "l": "Activated MAPK phosphorylates RAF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11448", "l": "NAD(+) + pregnan-21-ol = H(+) + NADH + pregnan-21-al", "d": []}, {"i": "EC:1.1.1.150", "l": "\"21-hydroxysteroid dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019133", "l": "choline monooxygenase activity", "d": ["Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909738", "l": "SHP1 and SHP2 bind the common beta chain (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0019798", "l": "procollagen-proline dioxygenase activity", "d": ["Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L-proline + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "71.415093686714229", "identifiers": [{"i": "GO:0016684", "l": "oxidoreductase activity, acting on peroxide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor."]}, {"i": "EC:1.11.-.-", "l": "\"Acting on a peroxide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378952", "l": "Thyrotropin is a heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33698", "l": "C20 sphinganine + NADP(+) <=> 3-oxoeicosasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102625", "l": "cirsimaritin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: cirsimaritin + S-adenosyl-L-methionine <=> salvigenin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196017", "l": "Dynamin is recruited to the gap junction plaque (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865107", "l": "MICAL1 produces NADP+, H2O2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19837", "l": "D-sorbitol 6-phosphate + NAD(+) = beta-D-fructose 6-phosphate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.140", "l": "\"sorbitol-6-phosphate 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042736", "l": "NADH kinase activity", "d": ["Catalysis of the reaction: ATP + NADH = ADP + 2 H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50922", "l": "chromopyrrolate + H(+) + 2 H2O + NH4(+) => 2 2-iminio-3-(indol-3-yl)propanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25366", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) <=> H(+) + momilactone A + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54164", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60577", "l": "coenzyme M + methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] => Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209910", "l": "Iodide is taken up by thyroid epithelial cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052896", "l": "spermidine oxidase (propane-1,3-diamine-forming) activity", "d": ["Catalysis of the reaction: H2O + O2 + spermidine = 1,3-diaminopropane + 4-aminobutanal + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54769", "l": "[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine => [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17583", "l": "an L-alpha-amino acid + CO2 + NH4(+) => an N-carbamoyl-L-alpha-amino acid + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57802", "l": "4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite => 2,3-dinitrotoluene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210444", "l": "L-Glutamate loading of synaptic vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25634", "l": "laricitrin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + syringetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63513", "l": "biphenyl-2,2'-diol + H(+) + NADH + O2 => biphenyl-2,2',3-triol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55267", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine <=> di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44845", "l": "(R)-carnitine + eicosanoyl-CoA => CoA + O-eicosanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805285", "l": "PLK3 phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5444523", "l": "Formation of MSH1:PMS2 Complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65993", "l": "calciol + hnu => 5,6-trans-vitamin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54692", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (13E)-labda-7,13-dien-15-yl diphosphate", "d": []}, {"i": "EC:5.5.1.30", "l": "\"labda-7,13-dienyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097003", "l": "adipokinetic hormone receptor activity", "d": ["Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are protein or peptide hormones that are important for sugar and fat homeostasis in metazoa. In insects, they mobilize sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9761474", "l": "AMOT-2 binds CDH11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54343", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42848", "l": "8-demethyltetracenomycin C + dTDP-beta-L-rhamnose = 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.331", "l": "\"8-demethyltetracenomycin C L-rhamnosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395992", "l": "p-T,4S-IRF3 is dimerized (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41732", "l": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}, {"i": "EC:2.4.1.1", "l": "\"glycogen phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-378975", "l": "Follitropin is a heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46815", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH <=> 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73525", "l": "TTP(in) + UTP(out) => TTP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793122", "l": "MRM1 methylates guanosine-1145 of 16S rRNA yielding 2'-O-methylguanosine-1145 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21268", "l": "(R)-canadine + 2 NADP(+) = berberine + H(+) + 2 NADPH", "d": []}, {"i": "EC:1.5.1.31", "l": "\"berberine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102497", "l": "scyllo-inositol dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: scyllo-inositol + NADP <=> 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16863", "l": "(7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate => (8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661086", "l": "Defective SLC9A9 does not exchange Na+ for H+ across the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65718", "l": "an aldehyde + CO2 + H(+) + succinate + sulfate => 2-oxoglutarate + a primary linear alkyl sulfate ester + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3785684", "l": "Fibronectin degradation by CTSG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316347", "l": "RAB4A:GTP binds KIF3 and activates KIF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57769", "l": "2-nitrotoluene + NADH + O2 => 3-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21382", "l": "AMP + diphosphate + phytanoyl-CoA => 3,7,11,15-tetramethylhexadecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35218", "l": "H2O + XDP <=> H(+) + phosphate + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20562", "l": "3-hydroxypyruvate + H(+) => CO2 + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56798", "l": "adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate => ATP + cob(I)alamin-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74257", "l": "H(+) + L-homoserine + tRNA(Ser) => H2O + L-homoseryl-tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001139", "l": "RNA polymerase II complex recruiting activity", "d": ["Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36197", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.3.3", "l": "\"NADH oxidase (H2O2-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-708349", "l": "Activated NOD2 oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9717841", "l": "holo-FDPS dimer binds NBPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404134", "l": "RBP4:atROL binds TTR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22003", "l": "D-xylose + NADP(+) <=> D-xylono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186771", "l": "RNF111 binds SMAD7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47454", "l": "(3S)-hydroxy-(5Z-tetradecenoyl)-CoA => (2E,5Z)-tetradecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57502", "l": "2-methyl-cis-aconitate + H2O => 3-hydroxybutane-1,2,3-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.434", "l": "\"2-dehydro-3-deoxy-L-fuconate 4-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140584", "l": "chromatin extrusion motor activity", "d": ["A DNA translocase activity that folds chromosomal DNA and catalytically extends the newly formed loop, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814298", "l": "Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36027", "l": "CoA + NAD(+) + propanal = H(+) + NADH + propanoyl-CoA", "d": []}, {"i": "EC:1.2.1.87", "l": "\"propanal dehydrogenase (CoA-propanoylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75692", "l": "2'-deoxyadenosine(in) => 2'-deoxyadenosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59469", "l": "an S-substituted glutathione + H2O => an S-substituted L-cysteinylglycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.25", "l": "\"mitogen-activated protein kinase kinase kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1470009", "l": "Phosphorylation of STATs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22341", "l": "3-hydroxybenzyl alcohol + NADP(+) => 3-hydroxybenzaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848250", "l": "ACBD6 binds LCFA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198813", "l": "GSTO dimers reduce DeHA to AscH- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678327", "l": "MIOX oxidises Ins to GlcA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008885", "l": "glutathionylspermidine synthase activity", "d": ["Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38700", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16093", "l": "(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377644", "l": "Release of CSK from SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30329", "l": "all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55733", "l": "19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68767", "l": "(R)-3-phenyllactate + 3 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022D + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36475", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63453", "l": "3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin => GMP + H(+) + oxidized 3PG-factor420-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817575", "l": "ERO1B oxidizes P4HB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0047929", "l": "gluconate dehydratase activity", "d": ["Catalysis of the reaction: D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15855", "l": "17alpha-hydroxyprogesterone + H(+) + NADH => (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451895", "l": "IL2RG binds JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39394", "l": "(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH <=> (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.371", "l": "\"polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 2,3-alpha-mannosylpolymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983427", "l": "Expression of peptide bound class I MHC on cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47673", "l": "H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) => 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.267", "l": "\"flavonoid 3',5'-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209815", "l": "Tyrosine is monoiodinated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928627", "l": "EPHB phosphorylates TIAM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72736", "l": "UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) => UDP-N-acetyl-alpha-D-galactosamine(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.55", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008830", "l": "dTDP-4-dehydrorhamnose 3,5-epimerase activity", "d": ["Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-372542", "l": "Loading of dopamine into synaptic veiscles (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21429", "l": "(2R)-3-sulfolactate => H(+) + pyruvate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32816", "l": "Hg(2+)(in) => Hg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0036374", "l": "glutathione hydrolase activity", "d": ["Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38344", "l": "(20S)-ginsenoside Rd + H2O => (20S)-ginsenoside Rg3 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44978", "l": "CoA + O-propanoyl-(R)-carnitine => (R)-carnitine + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867098", "l": "Glycophorins bind plasmodium falciparum Ags (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43023", "l": "L,L-cystathionine <=> 2-aminoprop-2-enoate + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15215", "l": "(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA => (R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51741", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A => a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0034595", "l": "phosphatidylinositol phosphate 5-phosphatase activity", "d": ["Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63541", "l": "H2O + neurotensin => L-leucine + neurotensin-(1-12)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35869", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047540", "l": "2-enoate reductase activity", "d": ["Catalysis of the reaction: butanoate + NAD+ = 2-butenoate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44920", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH = (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.128", "l": "\"(RS)-norcoclaurine 6-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937807", "l": "SRC phosphorylates RUNX3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-445714", "l": "Aquaporin-3 passively transports water out of cell (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11493", "l": "H(+) + O-phospho-L-threonine => (R)-1-aminopropan-2-yl phosphate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28846", "l": "choline(in) + H(+)(in) <=> choline(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29691", "l": "alpha-maltotetraose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22780", "l": "(9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625123", "l": "Defective SLC20A2 does not cotransport Pi, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46421", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396029", "l": "Latent TGF-beta-3 binds integrins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193668", "l": "p75NTR and RHOA-GDI interact (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37268", "l": "H2O + L-alanyl-L-aspartate => L-alanine + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372903", "l": "lactate + NAD+ <=> pyruvate + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38381", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0016825", "l": "hydrolase activity, acting on acid phosphorus-nitrogen bonds", "d": ["Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond."]}, {"i": "EC:3.9.1.-", "l": "\"Acting on phosphorus-nitrogen bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48262", "l": "CMP + ganglioside GD1a + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53858", "l": "3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH => NADP(+) + ursocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29378", "l": "AMP + H2O <=> adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004708", "l": "MAP kinase kinase activity", "d": ["Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74473", "l": "(Z)-4'-methoxydehydrocyclopeptine + CO2 + H2O + succinate => (-)-4'-methoxycyclopeptine + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009558", "l": "IL34 dimer binds SDC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77077", "l": "Capping complex formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390598", "l": "Myosin Binds ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265951", "l": "Phosphorylation of FANCG at S7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807008", "l": "PTPRJ dephosphorylates MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660665", "l": "Caspase-8 binds MALT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995376", "l": "BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33699", "l": "C20 sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19729", "l": "acetoacetate + H(+) = acetone + CO2", "d": []}, {"i": "EC:4.1.1.4", "l": "\"acetoacetate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6790038", "l": "Expression of HSP90B1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351871", "l": "Caspase-mediated cleavage of Z0-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12016", "l": "(2E,6E)-farnesyl diphosphate = (-)-germacrene D + diphosphate", "d": []}, {"i": "EC:4.2.3.75", "l": "\"(-)-germacrene D synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419049", "l": "ROCK activation by RHO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070975", "l": "FHA domain binding", "d": ["Binding to a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-481044", "l": "Surface deployment of platelet alpha granule membrane components (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21680", "l": "(2S)-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2", "d": []}, {"i": "EC:1.1.3.27", "l": "\"hydroxyphytanate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66394", "l": "ADP + H(+) + phosphate + prostaglandin E1(out) => ATP + H2O + prostaglandin E1(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664850", "l": "ATM binds PEX5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13760", "l": "(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose <=> (Z)-desulfoglucotropeolin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60445", "l": "an S-substituted L-cysteinylglycine + H2O => an S-substituted L-cysteine + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106329", "l": "L-phenylalaine oxidase activity", "d": ["Catalysis of the reaction: H2O + L-phenylalanine + O2 = 3-phenylpyruvate + H2O2 + NH4(+)."]}, {"i": "RHEA:61240", "l": "H2O + L-phenylalanine + O2 = 3-phenylpyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428750", "l": "Gq activation by TP receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018785", "l": "RHOBTB2 binds GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32542", "l": "(2E)-geranyl diphosphate <=> (+)-car-3-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-179410", "l": "Association of Nek2A with MCC:APC/C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40789", "l": "CoA + H(+) + tetracosanoate => H2O + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11723", "l": "ATP + 2 H2O + N-methylhydantoin <=> ADP + 2 H(+) + N-carbamoylsarcosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046811", "l": "histone deacetylase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58852", "l": "(6E)-8-oxogeraniol + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31349", "l": "2-cis-(+)-abscisate + beta-D-glucose + H(+) => (+)-abscisic acid D-glucopyranosyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45742", "l": "5-hydroxyectoine + CO2 + succinate => 2-oxoglutarate + L-ectoine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205262", "l": "Direct recruitment of PI3K to p-KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50910", "l": "A + a 3-demethylubiquinol + H2O => a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40711", "l": "1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17757", "l": "H(+) + L-methionine = 3-(methylsulfanyl)propanamine + CO2", "d": []}, {"i": "EC:4.1.1.57", "l": "\"methionine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14043", "l": "mandelonitrile + vicianose => (R)-vicianin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67961", "l": "4-amino-L-phenylalanine + S-adenosyl-L-methionine => 4-methylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57542", "l": "a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+) => a 5'-end NTP-ribonucleotide-RNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0031956", "l": "medium-chain fatty acid-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + a medium-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13943", "l": "ADP + D-glyceraldehyde 3-phosphate + H(+) => ATP + D-glyceraldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000074", "l": "TCN2 binds RCbl in the circulation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48834", "l": "15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008692", "l": "IL37(?-218) binds SMAD3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021050", "l": "HSBP1 oligomer binds ESRs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676268", "l": "Formation of the MLL4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193695", "l": "IRAK interacts with TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11972", "l": "4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide", "d": []}, {"i": "EC:1.16.3.2", "l": "\"bacterial non-heme ferritin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25652", "l": "(2R,5R)-isopulegone + NADP(+) <=> (6R)-isopiperitenone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9754974", "l": "ADK phosphorylates RBV (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34368", "l": "acrylamide + H2O => acrylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58248", "l": "5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = ADP-D-ribose + H(+) + L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.34", "l": "\"monoprenyl isoflavone epoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187382", "l": "Degradation of ubiquitinated SMAD3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74640", "l": "AMP(out) + CMP-N-acetyl-beta-neuraminate(in) => AMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198508", "l": "MDH1 oxidizes MAL to OA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30781", "l": "2-dehydro-D-gluconate + FADH2 => D-gluconate + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21709", "l": "H2O + S-adenosyl-L-homocysteine => adenosine + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626242", "l": "p-GFAP:GFAP dissociates from LAMP2a multimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25736", "l": "L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111238", "l": "Formation of ADAR2  homodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36088", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350403", "l": "DGO binds to PK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070497", "l": "6-carboxy-5,6,7,8-tetrahydropterin synthase activity", "d": ["Catalysis of the reaction: 7,8-dihydroneopterin triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52080", "l": "12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39186", "l": "3-oxodocosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxydocosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73900", "l": "ATP + cadaverine + L-glutamate => ADP + gamma-L-glutamylcadaverine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866269", "l": "ARRB bind GPCRs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009496", "l": "plastoquinol--plastocyanin reductase activity", "d": ["Catalysis of the reaction: 2 H+[side 1] + 2 oxidized plastocyanin + plastoquinol-1 = 2 H+[side 2] + 2 reduced plastocyanin + plastoquinone. This reaction involves the concomitant transfer of 2 H+ ions across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417898", "l": "P2Y4 receptor can bind to UTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16368", "l": "digallate + H2O <=> 2 3,4,5-trihydroxybenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614544", "l": "Sulfite is oxidized to sulfate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047858", "l": "dihydroxyfumarate decarboxylase activity", "d": ["Catalysis of the reaction: dihydroxyfumarate + H+ = 2-hydroxy-3-oxopropanoate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47108", "l": "cholate + taurine = H2O + taurocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56457", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole => 12-epi-fischerindole U", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59936", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35936", "l": "2 ATP + L-proline + L-tryptophan => 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700701", "l": "T-type VDCC bind T-type VDCC blockers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30634", "l": "alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate <=> beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11437", "l": "4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 => 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48505", "l": "D-glycero-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-D-manno-heptose 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36491", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA = (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008493", "l": "tetracycline transmembrane transporter activity", "d": ["Enables the transfer of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426209", "l": "DAG activation of TRPC channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389862", "l": "Conversion of glyoxylate to oxalate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29203", "l": "dimethyl sulfoxide + menaquinol-8 = dimethyl sulfide + H2O + menaquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.120", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211951", "l": "CYP1B1 4-hydroxylates EST17b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.86", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004994", "l": "somatostatin receptor activity", "d": ["Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1471322", "l": "Beta-defensins are secreted (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218811", "l": "DOCK180:ELMO binds CRK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034847", "l": "naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: naphthyl-2-hydroxymethyl-succinyl-CoA = naphthyl-2-oxomethyl-succinyl-CoA + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26257", "l": "dehydroabietadienol + H(+) + NADPH + O2 = dehydroabietadienal + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028724", "l": "AMOT proteins bind YAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417843", "l": "P2Y13 binds ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851933", "l": "MET phosphorylates GAB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749253", "l": "Formation of MCM2-7 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15338", "l": "H2O + phenylglyoxylyl-CoA => CoA + H(+) + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61281", "l": "4-aminobutanoate + H2O + O2 => H2O2 + NH4(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21788", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070553", "l": "nicotinic acid receptor activity", "d": ["Combining with nicotinic acid to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10102", "l": "a fatty acid + a sterol + H(+) => a sterol ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975633", "l": "atROL binds to RBP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082391", "l": "Trimerization of HSF1 in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74591", "l": "(+)-exo-beta-bergamotene + 3 O2 + 2 reduced [NADPH--hemoprotein reductase] = 5-dehydro-6-demethoxyfumagillol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.184", "l": "\"5-dehydro-6-demethoxyfumagillol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850794", "l": "SPINK6 binds KLK5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-982765", "l": "Growth hormone forms dimers and oligomers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0016827", "l": "hydrolase activity, acting on acid carbon-phosphorus bonds", "d": ["Catalysis of the hydrolysis of any acid carbon-phosphorus bond."]}, {"i": "EC:3.11.-.-", "l": "\"Acting on carbon-phosphorus bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32205", "l": "(4-hydroxyphenyl)acetaldehyde + methylamine => (R)-synephrine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58574", "l": "H2O2 + precondylocarpine acetate => O-acetyl-15alpha-stemmadenine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35850", "l": "ATP + sphing-4-enine <=> ADP + H(+) + sphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30487", "l": "H(+) + N,N-dihydroxy-L-isoleucine = (1E,2S)-2-methylbutanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875558", "l": "RAPGEF1 binds CRK,CRKL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72469", "l": "6 CO2 + 8 CoA + H2O + o-orsellinate depside => 2 acetyl-CoA + 5 H(+) + 6 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28263", "l": "3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose => 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34367", "l": "acrylamide + H2O = acrylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46082", "l": "NAD(+) + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73374", "l": "(R)-pantothenate(out) + 2 Na(+)(out) <=> (R)-pantothenate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027042", "l": "CPY4 ω-oxidises 14(S)-HDHA to MaR-L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46748", "l": "carboxyphosphate + NH4(+) = carbamate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37785", "l": "1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58537", "l": "glycine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35791", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine = H(+) + kanamycin X + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70240", "l": "a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol => an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237119", "l": "Acireductone is oxidized to MOB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34256", "l": "sporulenol => (R)-tetraprenyl-beta-curcumene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000830", "l": "inositol hexakisphosphate 4-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990965", "l": "cytosylglucuronate decarboxylase activity", "d": ["Catalysis of the reaction: cytosylglucuronic acid + H+ = cytosylarabinopyranose + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.32", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45694", "l": "N-(octanoyl)-sphing-4-enine-1-phosphate(out) => N-(octanoyl)-sphing-4-enine-1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14894", "l": "D-ornithine => (2R,4S)-2,4-diaminopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83791", "l": "Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.-.-", "l": "\"Catalysing the translocation of hydrons\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43817", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761812", "l": "AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625574", "l": "Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371422", "l": "ATP hydrolysis by HSP70 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043839", "l": "lipid A phosphate methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosylmethionine (SAM) to the 1-phosphate group of lipid A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41330", "l": "(12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607744", "l": "MALT1 binds BCL10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48637", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52742", "l": "aminomethylphosphonate + glyoxylate + H(+) + H2O2 => glyphosate + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73928", "l": "griseophenone D + S-adenosyl-L-methionine => griseophenone C + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15651", "l": "CO2 + NH4(+) => carbamate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130706", "l": "MHC class II antigen processing (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109858", "l": "MAP2K2 binds MAPK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29959", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose = alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49939", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23055", "l": "ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] <=> ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24417", "l": "2,4'-dihydroxyacetophenone + O2 => 4-hydroxybenzoate + formate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350769", "l": "trans-Golgi Network Coat Activation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674140", "l": "PAQR3 binds inactive RAFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45525", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin alpha-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57366", "l": "(6S)-NADHX => H2O + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12618", "l": "ATP + N-acetyl-alpha-D-galactosamine => ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445700", "l": "Myosin Binds ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62591", "l": "2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) <=> 4-hydroxybenzyl alcohol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62697", "l": "O2 + 4 tellimagrandin II => 2 cornusiin E + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168849", "l": "tBID binds to inactive BAX protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24004", "l": "butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.158", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202216", "l": "Phosphorylation of SLP-76 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21167", "l": "a carboxylic ester + H2O <=> a carboxylate + an alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31250", "l": "H(+) + prop-2-ynal + pyrroloquinoline quinol <=> prop-2-yn-1-ol + pyrroloquinoline quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40357", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683714", "l": "Unphosphorylated nucleoprotein translocates to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60859", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33009", "l": "(+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36660", "l": "carbamoyl phosphate + descarbamoylnovobiocin => novobiocin + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11887", "l": "3'-phosphoadenylyl sulfate + cortisol <=> adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51049", "l": "5alpha-androstan-3,17-dione + A => AH2 + androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33460", "l": "H(+) + NADPH + zymosterone => NADP(+) + zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29781", "l": "ADP + H(+) + L-methionine(in) + phosphate => ATP + H2O + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32150", "l": "H2O + sepiapterin <=> 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35934", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose <=> 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73415", "l": "(-)-cyclopenine = H(+) + methyl isocyanate + viridicatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47496", "l": "lithocholate + NADP(+) = 3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.392", "l": "\"3alpha-hydroxycholanate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209536", "l": "IkB is ubiquitinated and degraded (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42737", "l": "guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30660", "l": "4-(phosphooxy)-L-threonine + H2O => 4-hydroxy-L-threonine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956676", "l": "YAP1 binds TP73 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46783", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71244", "l": "chloride(out) + hypotaurine(out) + 2 Na(+)(out) => chloride(in) + hypotaurine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2318752", "l": "miR-26A microRNAs bind PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58376", "l": "decan-1-ol + NADP(+) = decanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46248", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (14Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444202", "l": "Receptor FFAR1 binds free fatty acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60301", "l": "N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30122", "l": "dodecanoyl-[ACP] + H2O <=> dodecanoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671829", "l": "JAK2 Phosphorylates STAT5 in Response to Leptin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629369", "l": "NEIL3 recognizes and binds to thymine glycol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134914", "l": "Beta-catenin migrates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254251", "l": "ERBB4s80 binds YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17404", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate <=> 4-carboxy-2-hydroxy-cis,cis-muconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65712", "l": "alpha-D-glucose 1-phosphate + GDP-beta-L-galactose = beta-L-galactose 1-phosphate + GDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047222", "l": "mannotetraose 2-alpha-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose + UDP-N-acetyl-D-glucosamine = 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18203", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45425", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57460", "l": "(E)-sinapyl alcohol + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19019", "l": "ADP + H(+) + NADH + phosphate => (6S)-NADHX + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75518", "l": "H2O + N-acetyl-L-cysteine <=> acetate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73365", "l": "beta-alanyl-dopamine + H(+) + holo-[peptidyl-carrier protein] => beta-alanyl-[peptidyl-carrier protein] + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847537", "l": "RAB43:GTP binds USP8NL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54564", "l": "a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)", "d": []}, {"i": "EC:2.7.7.79", "l": "\"tRNA(His) guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25405", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate => (R)-3-hydroxy-3-methyl-2-oxopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74569", "l": "L-glutamate(out) + N-acetyl-L-cysteine(in) => L-glutamate(in) + N-acetyl-L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848606", "l": "PTK6 phosphorylates PXN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69088", "l": "butanal + H2O + NAD(+) = butanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.43", "l": "\"phosphogluconate 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700156", "l": "Active ALK dimer binds IRS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9817575", "l": "ERO1B oxidizes P4HB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51008", "l": "2 Fe(III)-[cytochrome cL] + methanol = 2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38055", "l": "CTP + phytol = CDP + H(+) + phytyl phosphate", "d": []}, {"i": "EC:2.7.1.182", "l": "\"phytol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33185", "l": "citrate(out) => citrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16617", "l": "beta-D-glucosyl-(1->3)-D-glucose + phosphate = alpha-D-glucose 1-phosphate + D-glucose", "d": []}, {"i": "EC:2.4.1.31", "l": "\"laminaribiose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25484", "l": "(2E)-geranyl diphosphate = (1S,4R)-camphene + diphosphate", "d": []}, {"i": "EC:4.2.3.117", "l": "\"(-)-camphene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017507", "l": "RHOJ binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63983", "l": "4-thiouridine + ATP <=> 4-thiouridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26551", "l": "(S)-piperazine-2-carboxamide + H2O => (S)-piperazine-2-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13157", "l": "(R)-glycerate + CO2 + NADP(+) = 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353455", "l": "Autophosphorylation of DNA-PKcs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38821", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47992", "l": "H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)", "d": []}, {"i": "EC:7.1.1.1", "l": "\"proton-translocating NAD(P)(+) transhydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62618", "l": "a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+) => a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016710", "l": "trans-cinnamate 4-monooxygenase activity", "d": ["Catalysis of the reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626228", "l": "The distal appendage proteins recruit TTBK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426566", "l": "Interaction of DAP12 and CLM7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005309", "l": "creatine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in)."]}, {"i": "REACT:R-HSA-200396", "l": "Creatine transport across the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592240", "l": "Formation of NRF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113402", "l": "Formation of DSIF:NELF:early elongation complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45662", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3364014", "l": "Recruitment of SET1 methyltransferase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54840", "l": "H(+) + NADPH + O2 + octan-3-one = H2O + NADP(+) + pentyl propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17298", "l": "2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43228", "l": "L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55380", "l": "a 3alpha-hydroxy bile acid CoA + NAD(+) = a 3-oxo bile acid CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196026", "l": "Dab2 is recruited to the junctional plaques (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9006873", "l": "IL21 receptor STAT binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12362", "l": "13-(2-methylcrotonoyloxy)lupanine + CoA => (2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029451", "l": "Activation of RAC1 by VAV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55155", "l": "H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein] <=> (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619666", "l": "L-PRX:DRP2 binds dystroglycan and laminin-211 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20977", "l": "a primary nitroalkane + H2O + O2 => an aldehyde + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63825", "l": "2 3-(4-hydroxyphenyl)pyruvate => aspulvinone E + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433711", "l": "Cis-homodimerization of nectins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41092", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25980", "l": "(5S)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66629", "l": "(2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2 => (2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44935", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.1", "l": "\"alpha-amylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692880", "l": "HRH3 binds Hist (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396009", "l": "STING binds c-di-GMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68652", "l": "2 L-homocysteine = H(+) + hydrogen sulfide + L-homolanthionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9652264", "l": "ERBB2 binds TKIs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18820", "l": "acetyl-CoA + malonate <=> acetate + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66650", "l": "african-3-ene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674019", "l": "BRAP binds KSR1:MARK3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209200", "l": "HEP is phosphorylated and activated by Phospho TAK1:TAB2 kinase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.42", "l": "\"[glycogen-synthase-D] phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626256", "l": "HSPA8:LAMP2a multimers depolymerizes to monomers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374686", "l": "L1 interaction with Integrins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102060", "l": "endo-alpha-bergamotene synthase activity", "d": ["Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate <=> (-)-endo-alpha-bergamotene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015551", "l": "3-hydroxyphenyl propanoate transmembrane transporter activity", "d": ["Enables the transfer of 3-hydroxyphenyl propanoate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47411", "l": "(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O <=> (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29114", "l": "H(+) + NADPH + ubiquinone-8 <=> NADP(+) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48947", "l": "ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34983", "l": "sulfate(in) = sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619355", "l": "CaMKK autophosphorylates in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50590", "l": "15-oxoprostaglandin F2alpha + H(+) + NADPH => 13,14-dihydro-15-oxo-PGF2alpha + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211968", "l": "CYP2W1 oxidises INDOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19282", "l": "(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] => acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028598", "l": "Phosphorylation of YAP by LATS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65787", "l": "2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43621", "l": "L-serine + NADP(+) => aminoacetaldehyde + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52607", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP <=> 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56306", "l": "21-phosphorifampicin + AMP + 2 H(+) + phosphate => ATP + H2O + rifampicin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24259", "l": "ATP + kanamycin A <=> ADP + H(+) + kanamycin 3'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497794", "l": "Salvage - BH2 is reduced to BH4 by DHFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12195", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-921155", "l": "p-STAT5 dissociates from the receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395768", "l": "LPL hydrolyses TGs from mature CMs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75638", "l": "(9Z)-octadecenoate + O2 <=> 10-hydroperoxy-(8E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875661", "l": "GGA3 associates with activated MET receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009452", "l": "SMURF1 gene expression is stimulated by RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48897", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a => 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58122", "l": "3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate => ATP + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2214351", "l": "PLK1 phosphorylates GORASP1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46615", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol <=> (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250220", "l": "Homodimerization of ERBB4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001665", "l": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69432", "l": "3 [thioredoxin]-dithiol + arsenic triglutathione + 3 S-adenosyl-L-methionine = 3 [thioredoxin]-disulfide + 3 glutathione + 3 H(+) + 3 S-adenosyl-L-homocysteine + trimethylarsine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27439", "l": "glutathione amide disulfide + 2 H2O => 2 glutathione amide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38238", "l": "(9Z)-octadecenoyl-CoA + octadecan-1-ol <=> 1-O-octadecyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941895", "l": "Formation of CDK4/6:CCND complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44229", "l": "9-decenoate + ATP + CoA => 9-decenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29310", "l": "FMNH2 + methanesulfonate + O2 <=> FMN + formaldehyde + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21259", "l": "3-phosphoshikimate + phosphoenolpyruvate <=> 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19358", "l": "H(+) + L-proline betaine + NADPH + O2 => formaldehyde + H2O + N-methyl-L-proline + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160935", "l": "SMURF1 ubiquitinates RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64699", "l": "benzyl alcohol + NAD(+) <=> benzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-217255", "l": "FMO1:FAD N-oxidises TAM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0043843", "l": "ADP-specific glucokinase activity", "d": ["Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14879", "l": "ADP + L-glutamyl 5-phosphate => ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67354", "l": "6-O-malonyl-rhaponticin + CoA => malonyl-CoA + rhaponticin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442387", "l": "ZIP8 mediates zinc influx into cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390438", "l": "FAR2 reduces PalmCoA to HXOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53853", "l": "glycocholate + NAD(+) => 7-oxo-glycodeoxycholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.34", "l": "\"acyl-lipid (9+3)-(E)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46776", "l": "a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.45", "l": "\"sn-1 oleoyl-lipid 12-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174157", "l": "Degradation of multiubiquitinated Cyclin B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38698", "l": "a cardiolipin(in) <=> a cardiolipin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11221", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63414", "l": "2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O => 2,4,6-trichlorophenol + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204850", "l": "Interaction of Tie2 and Dok-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688797", "l": "ATXN3 family cleave Ub chains (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63106", "l": "16-hydroxy-ilicicolin A epoxide + H2O + NADP(+) => H(+) + ilicicolin A epoxide + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654573", "l": "Activated FGFR1 binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60034", "l": "8-oxo-GDP + H(+) + phosphate => 8-oxo-GTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29884", "l": "ATP + H2O + L-ornithine(out) => ADP + H(+) + L-ornithine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23628", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.65", "l": "\"3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932037", "l": "RUNX1 and ESR1 bind the KCTD6 gene enhancer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71451", "l": "bradykinin + H2O = bradykinin(1-7) + L-Phe-L-Arg", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44354", "l": "ADP + dapdiamide C + H(+) + phosphate => ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11881", "l": "(S)-6-hydroxynicotine + H2O + O2 => 6-hydroxypseudooxynicotine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66907", "l": "A + cannabinerolate <=> AH2 + cannabichromenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16187", "l": "a carboxylate + 2 H(+) + NADH => an aldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52079", "l": "13-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.18", "l": "\"ATP deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696275", "l": "RND2 binds GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38443", "l": "a fatty acyl-CoA + a long chain fatty alcohol = a wax ester + CoA", "d": []}, {"i": "EC:2.3.1.75", "l": "\"long-chain-alcohol O-fatty-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44311", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009936", "l": "RNASEL cleaves cellular ssRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46997", "l": "6-hydroxy-N-methylmyosmine + H2O => 6-hydroxypseudooxynicotine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13529", "l": "(3S)-citramalate = H2O + mesaconate", "d": []}, {"i": "EC:4.2.1.34", "l": "\"(S)-2-methylmalate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69327", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate <=> 4-methylsulfanylbutyl isothionate + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66051", "l": "2-oxobutanoate + L-kynurenine <=> (2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66385", "l": "(2E,6E,10E,14E)-geranylfarnesol => scalar-17(25)-en-19-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43387", "l": "ATP + L-arginyl-[protein] <=> ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27574", "l": "(3R)-piperidine-3-carboxamide + H2O = (3R)-piperidine-3-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59751", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.13", "l": "\"L-methionine (S)-S-oxide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53016", "l": "chlorohydroquinone + 2 glutathione = chloride + glutathione disulfide + H(+) + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72003", "l": "(S)-lactate(in) + urate(out) = (S)-lactate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15508", "l": "(S)-2-hydroxymethylglutarate + NAD(+) <=> 2-formylglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64254", "l": "CoA + H(+) + N-tetradecanoylglycine => glycine + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69123", "l": "glyoxylate + L-phenylalanine <=> 3-phenylpyruvate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44143", "l": "CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate <=> acetyl-CoA + CO2 + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5688797", "l": "ATXN3 family cleave Ub chains (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.14", "l": "\"UMP/CMP kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19117", "l": "dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical", "d": []}, {"i": "EC:1.14.17.1", "l": "\"dopamine beta-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45607", "l": "D-glucaro-1,4-lactone <=> 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56071", "l": "an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296045", "l": "Activation of Potassium transport channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46044", "l": "(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16249", "l": "alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate", "d": []}, {"i": "EC:5.1.3.15", "l": "\"glucose-6-phosphate 1-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13422", "l": "an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate => an N-acylneuraminate 9-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63265", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 => 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935740", "l": "RUNX1 and GATA1 bind the promoter of the ITGA2B gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13629", "l": "(1S,5R)-carveol + NADP(+) = (R)-carvone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.243", "l": "\"carveol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938199", "l": "RUNX1:CBFB binds the MYL9 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1471322", "l": "Beta-defensins are secreted (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17499", "l": "ononin + UDP => formononetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-139941", "l": "Binding of IP3 to IP3 receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63173", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA => (25R)-3-oxocholest-4-en-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31393", "l": "all-trans-4,4'-diapolycopene + 4 FADH2 => 15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38243", "l": "(9Z)-octadecenoyl-CoA + eicosan-1-ol = 1-O-eicosanyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56116", "l": "2-all-trans-decaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0005351", "l": "carbohydrate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in)."]}, {"i": "TCDB:2.A.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419003", "l": "Interaction of Nectins with Afadin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769249", "l": "NPAS4 stimulates SYT10 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74363", "l": "coproporphyrin III(out) = coproporphyrin III(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51099", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809707", "l": "MTMR12 binds MTMR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13074", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O => guanosine 3',5'-bis(diphosphate) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683774", "l": "p-T68-CHEK2 dimerizes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16219", "l": "H(+) + L-arabinonate => H2O + L-arabinono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983700", "l": "SYK binds the activated BCR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948136", "l": "ULK1 Translocates to the mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42673", "l": "gamma-L-glutamyl-L-cysteine + hercynine + O2 => gamma-L-glutamyl-hercynylcysteine S-oxide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.13.3", "l": "\"histidine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665871", "l": "ADRM1 binds 26S proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68954", "l": "Mcm2-7 is phosphorylated by DDK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10968", "l": "a carboxylate + CoA + GTP = an acyl-CoA + GDP + phosphate", "d": []}, {"i": "EC:6.2.1.10", "l": "\"acid--CoA ligase (GDP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2301205", "l": "SETD8 monomethylates histone H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27395", "l": "dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+) => 2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28111", "l": "chloride + S-adenosyl-L-methionine => 5'-chloro-5'-deoxyadenosine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350769", "l": "trans-Golgi Network Coat Activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055043", "l": "5-oxovalerate dehydrogenase activity", "d": ["Catalysis of the reaction: 5-oxovalerate + NADP+ + H2O = glutarate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18648", "l": "2 putrescine <=> NH4(+) + sym-homospermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59606", "l": "H2O2 + N-(4-aminobutyl)-3-aminopropanal + NH4(+) => H2O + O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17337", "l": "catechol + O2 = (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": []}, {"i": "EC:1.13.11.2", "l": "\"catechol 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62267", "l": "hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) <=> hydrogencarbonate(in) + selenite(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031884", "l": "DPAn-6 SPMs translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74386", "l": "2 (S)-lactate(in) + prostaglandin E2(out) <=> 2 (S)-lactate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873794", "l": "PCTP binds PC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53957", "l": "gamma-L-glutamyl-[BtrI ACP] + H(+) => 4-aminobutanoyl-[BtrI ACP] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.97", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53154", "l": "H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11965", "l": "5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O => 5alpha-cholestane-3beta,5,6beta-triol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11069", "l": "(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35506", "l": "11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112342", "l": "Inactivation of MAP2K1 by CDK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67681", "l": "a long-chain fatty acyl-CoA + H2O => a long-chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187746", "l": "RIT/RIN are activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59122", "l": "2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2 => 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004335", "l": "galactokinase activity", "d": ["Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43877", "l": "3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA => 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786650", "l": "DDHD1,2 hydrolyse PA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64311", "l": "3-aminobutanoate + pyruvate <=> acetoacetate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15646", "l": "16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] => 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70872", "l": "L-glutamine(in) + L-valine(out) + Na(+)(out) => L-glutamine(out) + L-valine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18879", "l": "1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine => myo-inositol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63524", "l": "2-propylphenol + H(+) + NADH + O2 = 3-propylcatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32038", "l": "(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O <=> (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20759", "l": "(E)-caffeoyl-CoA + D-threo-isocitrate <=> 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990311", "l": "type-I cohesin domain binding", "d": ["Binding to a type-I cohesin domain of a protein. Type-I cohesin domain is the binding partner of type-I dockerin domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30252", "l": "2 a ubiquinol + n H(+)(in) + O2 => 2 a ubiquinone + n H(+)(out) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28675", "l": "alpha-D-galactose = beta-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909718", "l": "Formation of p-STAT1 homodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2317332", "l": "PIP3 recruits AKT to the membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56094", "l": "biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n) => bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761095", "l": "BHLHE22 homodimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49494", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O => GDP-4-dehydro-alpha-D-rhamnose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51359", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamine <=> (9Z)-octadecenoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.57", "l": "\"butanal dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44929", "l": "2-oxoheptanedioate + acetyl-CoA + H2O => (R)-trihomocitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29078", "l": "formate(out) + 2 H(+)(in) + ubiquinone-8 <=> CO2(out) + H(+)(out) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69383", "l": "2-hydroxy-4-methylpentanoate + O2 <=> 4-methyl-2-oxopentanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.72", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43835", "l": "5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030020", "l": "extracellular matrix structural constituent conferring tensile strength", "d": ["A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016492", "l": "G protein-coupled neurotensin receptor activity", "d": ["Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874849", "l": "CREBRF binds CREB3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654511", "l": "FGFRL1 dimer binds FGFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156910", "l": "Formation of eEF1B complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11217", "l": "a 2'-deoxyribonucleoside 5'-phosphate + ATP => a 2'-deoxyribonucleoside 5'-diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0010279", "l": "indole-3-acetic acid amido synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetic acid + an amino acid = an indole-3-acetic acid amide conjugate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004451", "l": "isocitrate lyase activity", "d": ["Catalysis of the reaction: isocitrate = glyoxylate + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706330", "l": "Active FLT3 binds to SOCS6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73331", "l": "(2R,3S)-piscidate + (E)-feruloyl-CoA = cimicifugate E + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50395", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + oxytetracycline <=> 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65581", "l": "H2O + TTP => H(+) + phosphate + TDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70971", "l": "citrate <=> isocitrate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55402", "l": "archaeosine(15) in tRNA => 7-cyano-7-carbaguanosine(15) in tRNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696266", "l": "RND2 binds effectors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29835", "l": "D-galactonate(in) + H(+)(in) = D-galactonate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008226", "l": "tyramine receptor activity", "d": ["Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53369", "l": "5,6-dihydrouridine(17) in tRNA + NADP(+) => H(+) + NADPH + uridine(17) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76466", "l": "CYP4A11 12-hydroxylates DDCX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24406", "l": "acetoacetate + acetyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30154", "l": "FADH2 + NADP(+) <=> FAD + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.16", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008011", "l": "structural constituent of pupal chitin-based cuticle", "d": ["The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-606349", "l": "Mis18 complex binds the centromere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30847", "l": "FAD + glutaryl-CoA + 2 H(+) = (2E)-butenoyl-CoA + CO2 + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67321", "l": "(2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate => sch 210971", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211239", "l": "Association of DFF40 with chromatin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56771", "l": "2 AH2 + all-trans-zeaxanthin + 2 O2 <=> 2 A + all-trans-adonixanthin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682011", "l": "LC3 binds ATG7 dimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32090", "l": "[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate <=> [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25374", "l": "(2S)-2-amino-4-deoxychorismate + FMN <=> 3-(1-carboxyvinyloxy)anthranilate + FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29686", "l": "alpha-maltohexaose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltopentaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40671", "l": "2-iminopropanoate + H2O = NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205319", "l": "Interaction of APS and p-KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857336", "l": "CEBPB homodimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614614", "l": "Cysteine is degraded to serine and H2S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804596", "l": "APAF1:CYCS binds APIP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19212", "l": "codeine + NADP(+) <=> codeinone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59987", "l": "an N(2)-acyl-L-glutamine + H2O <=> a carboxylate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13623", "l": "1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose => 4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193997", "l": "CYP11B1 oxidises 11DCORT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193068", "l": "CYP17A1 17-hydroxylates PREG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029272", "l": "Release of PLCG from FCGR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0022889", "l": "serine transmembrane transporter activity", "d": ["Enables the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid."]}, {"i": "RHEA:35031", "l": "L-serine(in) = L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32137", "l": "CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] => 2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57525", "l": "a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + H2O => a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57220", "l": "GTP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73596", "l": "dCMP + H2O => dUMP + NH4+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047065", "l": "sulochrin oxidase [(-)-bisdechlorogeodin-forming] activity", "d": ["Catalysis of the reaction: O2 + 2 sulochrin = 2 (2R)-bisdechlorogeodin + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28665", "l": "D-galactose + D-glucose => H2O + melibiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806613", "l": "Keratin tetramers bind to form unit length filaments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58885", "l": "AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 => A + chloramphenicol + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16740", "l": "H(+) + NADH + O2 + toluene <=> (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35347", "l": "3-hydroxyoctadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693125", "l": "RHOF binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69323", "l": "glucoerucin + H2O <=> (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0005353", "l": "fructose transmembrane transporter activity", "d": ["Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey."]}, {"i": "REACT:R-HSA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733969", "l": "Bile salts dissociate from FABP6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38884", "l": "a fatty acid + ATP + CoA => a fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13537", "l": "(2R)-3-phosphoglycerate + GDP-alpha-D-mannose = 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.217", "l": "\"mannosyl-3-phosphoglycerate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2219524", "l": "PDPK1 binds PIP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141673", "l": "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45482", "l": "(3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+) => gamma-hexachlorocyclohexane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-994148", "l": "LRRC16A binds F-actin capping protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71282", "l": "chloride(out) + L-leucine(out) + 2 Na(+)(out) <=> chloride(in) + L-leucine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0005017", "l": "platelet-derived growth factor receptor activity", "d": ["Combining with platelet-derived growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038058", "l": "TNFSF11 receptor activity", "d": ["Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36013", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654573", "l": "Activated FGFR1 binds SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73149", "l": "adenosine 3',5'-bisphosphate(in) + FAD(out) => adenosine 3',5'-bisphosphate(out) + FAD(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62666", "l": "deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine => (2'R)-atrovenetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6810076", "l": "DDO oxidizes D-Asp to OA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708866", "l": "pro-F2R binds vorapaxar (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390649", "l": "CHRM1,3,5 bind acetylcholine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75024", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate => 9-(9Z,12Z-octadecadienoyloxy)-octadecanoate + di-(9Z,12Z)-octadecadienoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59777", "l": "D-arabinitol + O2 => D-arabinose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605724", "l": "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71799", "l": "Ca(2+)(in) + H(+)(out) = Ca(2+)(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15095", "l": "3-(4-hydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187506", "l": "Translocation of p27 to the nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694522", "l": "Inner coat assembly and cargo binding (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48883", "l": "a quinone + CO + H2O <=> a quinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647978", "l": "pro-RAS proteins are farnesylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202203", "l": "Recruitment of PI3K to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44772", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 = 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23759", "l": "D-arabinono-1,4-lactone + O2 <=> dehydro-D-arabinono-1,4-lactone + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621073", "l": "Immediate Early (IE) Gene Expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635859", "l": "GLI:SUFU dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760099", "l": "AcK-NFE2L2 binds the GCLC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46942", "l": "ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate => AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53669", "l": "(2E,6E)-farnesyl diphosphate => (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18986", "l": "chorismate => isochorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086063", "l": "voltage-gated sodium channel activity involved in SA node cell action potential", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60878", "l": "a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+) => a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14283", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + sulfate => 2 Fe(III)-[cytochrome c] + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047960", "l": "glycine dehydrogenase activity", "d": ["Catalysis of the reaction: glycine + H2O + NAD+ = glyoxylate + NH3 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58847", "l": "(6E)-8-hydroxygeranial + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018594", "l": "MECP2 binds LBR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67072", "l": "a very long-chain fatty acyl-CoA + H2O = a very long-chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420243", "l": "GHRH receptor binds GHRH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11669", "l": "[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O => [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56471", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 <=> (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55391", "l": "(3R)-3-hydroxy-2,3-dihydrotabersonine + A <=> (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950415", "l": "Expression of heterogeneous nuclear ribonucleoprotein F (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28500", "l": "S-(hydroxymethyl)mycothiol => formaldehyde + mycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804955", "l": "ATM phosphorylates MDM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24501", "l": "adenosine 5'-tetraphosphate + H2O => ATP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008495", "l": "protoheme IX farnesyltransferase activity", "d": ["Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9007926", "l": "ATRX binds DAXX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44790", "l": "H(+) + menaquinol-11 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-11 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37157", "l": "1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49224", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24736", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde => 2-oxoglutarate + 4-hydroxybutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37309", "l": "glycine + L-asparagine => glycyl-L-asparagine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16043", "l": "[(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->3)-beta-D-glucosyl](n) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35137", "l": "L-alanyl-L-glutamate(in) => L-alanyl-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33945", "l": "4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide => H(+) + 2 L-arginine + 3 NADH + 4 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1470010", "l": "Dimerization of STATs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50918", "l": "AMP + an aldehyde + diphosphate + NADP(+) => a carboxylate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220966", "l": "NOTCH1 PEST domain mutants stimulate HES5 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51314", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71389", "l": "L-pipecolate(out) + Na(+)(out) => L-pipecolate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380294", "l": "Loss of C-Nap-1 from centrosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19313", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)", "d": []}, {"i": "EC:2.4.3.8", "l": "\"alpha-N-acetylneuraminate alpha-2,8-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45139", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate <=> 7,8-dihydroneopterin 3'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45410", "l": "dodecanoyl-CoA + NAD(+) => (2E)-dodecenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55846", "l": "calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP => calcidiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42476", "l": "2,2',3-trihydroxydiphenyl ether + H(+) + O2 = 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604731", "l": "Autocatalytic activation of MMP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15601", "l": "(E)-cinnamoyl-CoA + (R)-3-phenyllactate = (E)-cinnamate + (R)-3-phenyllactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6795460", "l": "SGK1 phosphorylates MDM2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990362", "l": "butanol dehydrogenase activity", "d": ["Catalysis of the reaction: butanal + NADH + H+ => n-butanol + NAD+."]}, {"i": "RHEA:33199", "l": "butan-1-ol + NAD(+) = butanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66788", "l": "N-methyl-L-dopa + O2 = (3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900747", "l": "NOTCH1 HD+PEST domain mutants bind DLL4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34328", "l": "4-nitrophenol + H(+) + NADPH + O2 => 1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43292", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65351", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA <=> 3-oxochol-4,6-dien-24-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45928", "l": "15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53138", "l": "5alpha-dihydrotestosterone sulfate + H(+) + NADPH => (3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-398040", "l": "Gbeta:gamma activation of PLC beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49639", "l": "H2O + methylglyoxal + O2 <=> H(+) + H2O2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44601", "l": "a fatty acid + ATP + H(+) => a fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17287", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30375", "l": "(2E,6E)-farnesyl diphosphate = (+)-thujopsene + diphosphate", "d": []}, {"i": "EC:4.2.3.79", "l": "\"thujopsene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-178208", "l": "SMAD7 binds to SMURF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856189", "l": "TNFSF8 binds TNFRSF8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74485", "l": "(-)-cyclopenine + CO2 + succinate => (Z)-dehydrocyclopeptine + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64502", "l": "3-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine => acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68250", "l": "L-tyrosine(out) + Na(+)(out) => L-tyrosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74734", "l": "Re-integration of insulin receptor into plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42904", "l": "guanosine(748) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.188", "l": "\"23S rRNA (guanine(748)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55193", "l": "2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 => 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73863", "l": "dopamine(out) = dopamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21909", "l": "NADP(+) + scytalone => H(+) + NADPH + naphthalene-1,3,6,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218814", "l": "PAK2 autophorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097269", "l": "all-trans-decaprenyl-diphosphate synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69951", "l": "3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydroteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203979", "l": "Coat Assembly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28755", "l": "a ubiquinone + sn-glycerol 3-phosphate = a ubiquinol + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928617", "l": "EPHB2 binds KALRN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39881", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102875", "l": "1-18:2-2-18:2-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.39", "l": "\"[butirosin acyl-carrier protein]--L-glutamate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62894", "l": "6 CO2 + 7 CoA + 2 H2O + nor-toralactone => acetyl-CoA + 6 H(+) + 6 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54777", "l": "1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine => [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672163", "l": "SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5140741", "l": "WNT5A binds FZD and ROR receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202724", "l": "P-selectin binds P-selectin ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857686", "l": "FITM1, FITM2 bind TAGs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9007926", "l": "ATRX binds DAXX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66370", "l": "4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA => 6-methyl-3,7-dioxodecanedioyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0032552", "l": "deoxyribonucleotide binding", "d": ["Binding to a deoxyribonucleotide, any compound consisting of a deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49516", "l": "2-oxoglutarate + an N(1)-methyladenosine in mRNA + O2 = an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": []}, {"i": "EC:1.14.11.54", "l": "\"mRNA N(1)-methyladenine demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24950", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + malonate => 3-hydroxy-3-methylglutarate + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49760", "l": "EDTA + FMNH2 + O2 = ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186798", "l": "GAP binds to PDGF-beta receptors only (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112121", "l": "Oxidative dealkylation of 1-etA damaged DNA By ALKBH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9676257", "l": "Formation of the SET1A complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16009", "l": "ATP + formate = ADP + formyl phosphate", "d": []}, {"i": "EC:2.7.2.6", "l": "\"formate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47929", "l": "(2S)-3-sulfolactaldehyde + H2O + NADP(+) => (2S)-3-sulfolactate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41141", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32065", "l": "8-oxo-dGMP + H(+) + phosphate => 8-oxo-dGDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50207", "l": "(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 <=> (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102659", "l": "UDP-glucose: 4-methylthiobutylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 4-methylthiobutylhydroximate <=> H+ + 3-methylthiopropyl-desulfoglucosinolate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70926", "l": "(R)-noradrenaline(out) + chloride(out) + Na(+)(out) <=> (R)-noradrenaline(in) + chloride(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52883", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate <=> 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71336", "l": "chloride(out) + L-tryptophan(out) + 2 Na(+)(out) => chloride(in) + L-tryptophan(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48525", "l": "ganglioside GP1c + H2O => ganglioside GQ1c + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170120", "l": "Translocation of Cdc25B to the cytoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30247", "l": "2 H2O + 4 hnu + 2 plastoquinone-9 = O2 + 2 plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29889", "l": "ADP + H(+) + L-lysine(in) + phosphate => ATP + H2O + L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9724745", "l": "PLG(20-810) binds aprotinin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27761", "l": "(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17632", "l": "alpha,alpha-trehalose(in) <=> alpha,alpha-trehalose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14715", "l": "5-dehydro-D-fructose + AH2 => A + keto-L-sorbose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016231", "l": "beta-N-acetylglucosaminidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58403", "l": "heptan-1-ol + NADP(+) <=> H(+) + heptanal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1878002", "l": "XYLTs transfer Xyl to core protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62383", "l": "carbaryl + H(+) + H2O <=> 1-naphthol + CO2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28696", "l": "hydrogencarbonate(in) => hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20376", "l": "ATP + CoA + propanoate <=> AMP + diphosphate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.916538309327947", "identifiers": [{"i": "GO:0004743", "l": "pyruvate kinase activity", "d": ["Catalysis of the reaction: = ADP + H+ + phosphoenolpyruvate => ATP + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28951", "l": "H(+)(in) + L-arabinose(in) = H(+)(out) + L-arabinose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035447", "l": "mycothiol synthase activity", "d": ["Catalysis of the reaction: 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = mycothiol + coenzyme A + H+. Mycothiol is also known as AcCys-GlcN-Ins and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as Cys-GlcN-Ins or desacetylmycothiol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913451", "l": "IL3RB is phosphorylated on Ser-585 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467761", "l": "A2E is phagocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878257", "l": "RUNX2 binds the IHH gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13801", "l": "3 H2O + hydrogen sulfide + 3 NADP(+) = 4 H(+) + 3 NADPH + sulfite", "d": []}, {"i": "EC:1.8.1.2", "l": "\"assimilatory sulfite reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045027", "l": "DNA end binding", "d": ["Binding to DNA ends exposed by the creation of double-strand breaks (DSBs)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008806", "l": "carboxymethylenebutenolidase activity", "d": ["Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114284", "l": "Release of Cytochrome c from mitochondria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75791", "l": "(S)-lactate(out) + Na(+)(out) = (S)-lactate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392752", "l": "Phosphorylation of L1 by CK-II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22854", "l": "3-hydroxypyruvate + L-alanine => L-serine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55186", "l": "2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylundecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19276", "l": "H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate <=> N-acetylneuraminate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805620", "l": "KAT6A and PML bind TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683429", "l": "nsp16 binds nsp10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52319", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2870221", "l": "E-selectin binds E-selectin ligand (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211874", "l": "CYP2S1 4-hydroxylates atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036505", "l": "prosaposin receptor activity", "d": ["Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34147", "l": "2-deoxy-L-scyllo-inosose + L-glutamine = 2-deoxy-scyllo-inosamine + 2-oxoglutaramate", "d": []}, {"i": "EC:2.6.1.100", "l": "\"L-glutamine:2-deoxy-scyllo-inosose aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354066", "l": "Translocation of PTK2 to Focal complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15221", "l": "a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)", "d": []}, {"i": "EC:3.6.1.26", "l": "\"CDP-diacylglycerol diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24514", "l": "3-(pyrazol-1-yl)-L-alanine + H2O => L-serine + pyrazole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59577", "l": "anserine + H2O => beta-alanine + N(pros)-methyl-L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59717", "l": "D-maltopentaono-1,5-lactone + H2O => D-maltopentaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30402", "l": "alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68159", "l": "(2E)-geranyl diphosphate + L-glutamate <=> diphosphate + N-geranyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388900", "l": "Neurotensin receptors can bind neurotensins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22643", "l": "NADP(+) + sphinganine <=> 3-oxosphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-213406", "l": "Disassociation of PLC-gamma1 from LAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21054", "l": "2-oxopropyl-coenzyme M + H(+) + NADH => (S)-2-hydroxypropyl-coenzyme M + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41258", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68610", "l": "Formation of ORC(2-5) complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0003696", "l": "satellite DNA binding", "d": ["Binding to satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55714", "l": "(9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+) => (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332356", "l": "CAMK2 binds MAP3K7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73865", "l": "Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15769", "l": "adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985201", "l": "ABCE1 binds RNASEL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649856", "l": "Oxidative damage to the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114683", "l": "Phosphorylation of Platelet Sec-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202489", "l": "Oligomerization of Bcl10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856189", "l": "TNFSF8 binds TNFRSF8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034317", "l": "nicotinic acid riboside kinase activity", "d": ["Catalysis of the reaction: ATP + nicotinic acid riboside = ADP + nicotinic acid mononucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209973", "l": "Tyrosine is diiodinated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23235", "l": "4 Fe(III)-[cytochrome c] + hydrazine <=> 4 Fe(II)-[cytochrome c] + 4 H(+) + N2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63901", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) => (2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17886", "l": "acetaldehyde => acetylene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032405", "l": "MutLalpha complex binding", "d": ["Binding to a MutLalpha mismatch repair complex."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033792", "l": "3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase activity", "d": ["Catalysis of the reactions: a 3alpha-hydroxy bile acid CoA + NAD+ = a 3-oxo bile acid CoA + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052826", "l": "inositol hexakisphosphate 2-phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912734", "l": "CBL:CRKL binds RAPGEF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029536", "l": "Expression of UGT1A3  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9796626", "l": "MIB2 ubiquitinates CFLAR  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014293", "l": "RAC2 GDIs block activation of RAC2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73275", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine = 4',7,8-trihydroxy-3'-methoxyflavone-7-olate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27725", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose <=> 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65499", "l": "3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH <=> 3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75900", "l": "1,2-diacyl-sn-glycero-3-phospho-N-acyl-L-serine + H2O => 1-acyl-sn-glycero-3-phospho-N-acyl-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57539", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + a ribonucleoside 5'-triphosphate <=> a 5'-end NTP-ribonucleotide-RNA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23180", "l": "a secondary alcohol + O2 = a ketone + H2O2", "d": []}, {"i": "EC:1.1.3.18", "l": "\"secondary-alcohol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917841", "l": "Acidification of Tf:TfR1 containing endosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55417", "l": "biochanin A + UDP-alpha-D-glucose => biochanin A 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199203", "l": "PANK1/3/4 phosphorylate PanK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20524", "l": "(R)-3-hydroxybutanoate + NAD(+) <=> acetoacetate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9761344", "l": "USP18 binds IKBKG within IKK complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15657", "l": "1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) = 3-methylcatechol + CO2 + NADH", "d": []}, {"i": "EC:1.3.1.68", "l": "\"1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444100", "l": "PROT mediates L-proline uptake (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72411", "l": "inulobiose = alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O", "d": []}, {"i": "EC:4.2.1.178", "l": "\"difructose-dianhydride-III synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013024", "l": "RHOB binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388468", "l": "AVP(20-28) binds AVPR1A,B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41838", "l": "3-oxooctanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + hexanoyl-[ACP] + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18034", "l": "benzoate + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047632", "l": "agmatine deiminase activity", "d": ["Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788611", "l": "HYKK phosphorylates 5HLYS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030744", "l": "luteolin O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + luteolin = 4',5,7-trihydroxy-3'-methoxyflavone + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57988", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose = (20S)-ginsenoside F2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64573", "l": "isopentenyl diphosphate + neryl diphosphate => (2Z,6Z)-farnesyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49368", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) = 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32949", "l": "a 1,2-diacyl-sn-glycerol + CoA => a 2-acylglycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53448", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14274", "l": "A + H2O + spermidine => 4-aminobutanal + AH2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849857", "l": "KLK5 cleaves and activates CELA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42157", "l": "androsterone + H(+) + NADPH => 5alpha-androstane-3alpha,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.105", "l": "\"L-tryptophan decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57178", "l": "N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] => L-arginyl-[protein] + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18912", "l": "2,4,6-trichlorophenol + S-adenosyl-L-methionine <=> 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45721", "l": "N-hexadecanoylsphing-4-enine(in) => N-hexadecanoylsphing-4-enine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42216", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33167", "l": "2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.3", "l": "\"RNA ligase (ATP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211193", "l": "Homodimerization  of DFF40 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45654", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48859", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 <=> (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989756", "l": "Expression of ME1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983285", "l": "RAD51B binds RAD51C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428625", "l": "Vesicular inhibitory amino acid transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928631", "l": "GIT1 binds bPIX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13201", "l": "glycine + L-arginine = guanidinoacetate + L-ornithine", "d": []}, {"i": "EC:2.1.4.1", "l": "\"glycine amidinotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938053", "l": "RUNX1:CBFB binds the SERPINB13 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42832", "l": "(2E)-octenal + H(+) + pyruvate = (S)-3-acetyloctanal + CO2", "d": []}, {"i": "EC:2.2.1.12", "l": "\"3-acetyloctanal synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67037", "l": "(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + 2-oxoglutarate + O2 => (3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010179", "l": "IAA-Ala conjugate hydrolase activity", "d": ["Catalysis of the reaction: indole-3-acetyl-alanine + H2O = indole-3-acetate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.26", "l": "\"[tau protein] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59139", "l": "ATP + citrate + D-ornithine <=> AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004361", "l": "glutaryl-CoA dehydrogenase activity", "d": ["3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429955", "l": "CCR4-NOT complex deadenylates mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66253", "l": "ATP + CoA + IC-asc-C7 => AMP + diphosphate + IC-asc-C7-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047588", "l": "5-aminopentanamidase activity", "d": ["Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17094", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67094", "l": "ADP + docosanoate(out) + H(+) + phosphate => ATP + docosanoate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858428", "l": "FCAMR binds IgA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34781", "l": "a 3-oxosteroid + H(+) + NADH => a 3alpha-hydroxysteroid + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706393", "l": "RHOBTB3 binds ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72447", "l": "a dicarboxylate(in) + estrone 3-sulfate(out) = a dicarboxylate(out) + estrone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668605", "l": "RAC2:GTP binds NOX2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65874", "l": "17beta-hydroxyandrostan-1,3-dione + AH2 => 1,17beta-dihydroxyandrostan-3-one + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73151", "l": "CoA(out) + FMN(in) = CoA(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388832", "l": "PI3K binds CD28 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140696", "l": "factor V -> factor Va + factor V activation peptide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425861", "l": "Activation of Protein Kinase C novel isoforms (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55046", "l": "(3E,5Z)-tetradecadienoate + CoA + H(+) => (3E,5Z)-tetradecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6799350", "l": "Exocytosis of specific granule membrane proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71196", "l": "H(+)(out) + Zn(2+)(out) => H(+)(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16687", "l": "a dolichyl hexadecanoate + CoA => di-trans,poly-cis-dolichol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35771", "l": "5-deoxy-5-amino-3-dehydroshikimate = 3-amino-5-hydroxybenzoate + H(+) + H2O", "d": []}, {"i": "EC:4.2.1.144", "l": "\"3-amino-5-hydroxybenzoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50934", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26111", "l": "UDP-N-acetyl-alpha-D-glucosamine = H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}, {"i": "EC:4.2.1.115", "l": "\"UDP-N-acetylglucosamine 4,6-dehydratase (inverting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082356", "l": "HSF1-mediated gene expression (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45957", "l": "(9Z)-octadecenoyl-CoA(in) => (9Z)-octadecenoyl-CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1834939", "l": "STING recruits TBK1 and IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10530", "l": "10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47409", "l": "(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O => (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112429", "l": "Formation of FACT complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20842", "l": "CO2 + histamine => H(+) + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002059", "l": "thymine binding", "d": ["Binding to thymine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10173", "l": "(3R)-hydroxybutanoate dimer + H2O => 2 (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195251", "l": "Assembly of the destruction complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66304", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide = a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36046", "l": "all-trans-8'-apo-beta-carotenal + O2 <=> 13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37404", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.9", "l": "\"glucose-6-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58224", "l": "L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56054", "l": "2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => 2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297333", "l": "Association of Acrosin Heavy and Light Chain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0030368", "l": "interleukin-17 receptor activity", "d": ["Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.46", "l": "\"L-peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33131", "l": "L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate = 3-phenylpyruvate + tetrahydrotyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49958", "l": "H2O2 + phenazine-1-carboxylate => 5,10-dihydrophenazine 1-carboxylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.71", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61571", "l": "an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14284", "l": "2 Fe(III)-[cytochrome c] + H2O + sulfite <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021596", "l": "Membrane estrogen receptors bind SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35221", "l": "8-oxo-dAMP + H(+) + phosphate => 8-oxo-dADP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68973", "l": "A + sn-glycerol 3-phosphate => AH2 + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58519", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] <=> 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60730", "l": "3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH => citral + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.688704758796746", "identifiers": [{"i": "GO:0016703", "l": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674095", "l": "PDGFRs bind type II TKI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43218", "l": "(24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56181", "l": "8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate => 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.37", "l": "\"acyl-CoA 5-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754480", "l": "p-2S-SMAD2,3:SMAD4, CTNNB1, and TBPL2 bind FOXH1:SMAD3:EOMES gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173709", "l": "C7 binds C5b:C6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11537", "l": "choline + H2O + 2 O2 => glycine betaine + H(+) + 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070740", "l": "tubulin-glutamic acid ligase activity", "d": ["Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190265", "l": "FGFR4 binds to FGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43477", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 => 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102924", "l": "gibberellin A44,2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: 2 H+ + gibberellin A44 + 2-oxoglutarate + O2 = gibberellin A98 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19558", "l": "AH2 + O2 + pregna-4,9(11)-diene-3,20-dione => 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48110", "l": "2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine => L-arginyl-[protein] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848774", "l": "PTK6 binds DOK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399952", "l": "Phosphorylation of LIMK-1 by PAK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63885", "l": "H2O2 + L-tyrosine => H2O + L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52894", "l": "H(+) + NADPH + nitrobenzene => H2O + NADP(+) + nitrosobenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57110", "l": "1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662851", "l": "Defective DCXR does not reduce L-xylulose to xylitol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928656", "l": "gamma-secretase cleaves EPHB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36748", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24422", "l": "formate + N-terminal L-methionyl-[peptide] => H2O + N-terminal N-formyl-L-methionyl-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0048306", "l": "calcium-dependent protein binding", "d": ["Binding to a protein or protein complex in the presence of calcium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876472", "l": "NPC2 binds CHOL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604360", "l": "Initial activation of proMMP2 by MMP14 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11224", "l": "ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.4", "l": "\"D-alanine--D-alanine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48904", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.15", "l": "\"guanosine phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000234", "l": "phosphoethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694462", "l": "ABHD6,12 hydrolyse 3AG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047232", "l": "galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyceramide + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22423", "l": "cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) <=> 2 H(+) + maleylacetate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9017797", "l": "NOTCH3 binds YBX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47270", "l": "H2O + monoanhydrobacterioruberin => bacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430311", "l": "Rsu-1 interacts with Pinch1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627078", "l": "XIAP binds CASP9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22204", "l": "3-hydroxyphenylacetate + H(+) + NADPH + O2 = H2O + homogentisate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001571", "l": "non-tyrosine kinase fibroblast growth factor receptor activity", "d": ["Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40375", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451310", "l": "Activation of Edited Kainate receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879910", "l": "JAK2 is phosphorylated, activated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52916", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58704", "l": "rifampicin hemiaminal = rifampicin ortho-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201603", "l": "Caspase-mediated cleavage of PKC theta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008660", "l": "1-aminocyclopropane-1-carboxylate deaminase activity", "d": ["Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112395", "l": "Abortive termination of elongation after arrest (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015410", "l": "ABC-type manganese transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62115", "l": "(3S)-3-hydroxy-D-aspartate <=> H2O + iminosuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38048", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36048", "l": "A + D-glyceraldehyde + H2O => (R)-glycerate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952371", "l": "MDM2 binds RUNX3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46922", "l": "CO2 + styrene => (E)-cinnamate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9702849", "l": "CALCR binds gepants (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47746", "l": "demethylphylloquinol + NADP(+) => demethylphylloquinone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31772", "l": "an all-trans-retinyl ester + H2O => 11-cis-retinol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67945", "l": "2-hydroxyhexadecanoate + O2 => 2-oxohexadecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65277", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120242", "l": "2-iminobutanoate deaminase activity", "d": ["Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879562", "l": "SLCO2B1 has a narrow substrate specificity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983266", "l": "Kinesins bind microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2213207", "l": "Formation of collagen networks (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15153", "l": "4-hydroxybenzoate + UDP-alpha-D-glucose = 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.194", "l": "\"4-hydroxybenzoate 4-O-beta-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034017", "l": "trans-2-decenoyl-acyl-carrier-protein isomerase activity", "d": ["Catalysis of the reaction: trans-dec-2-enoyl-[acyl-carrier protein] = cis-dec-3-enoyl-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102763", "l": "phytyl-P kinase activity", "d": ["Catalysis of the reaction: phytyl phosphate(2-) + a nucleoside triphosphate <=> (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + a nucleoside diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.52", "l": "\"trimerelysin I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32714", "l": "a (3R)-3-hydroxyacyl-CoA + NAD(+) <=> a 3-oxoacyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41434", "l": "5-hydroxy-3-methyl-L-tyrosine + H2O => 3-methyl-L-tyrosine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5099899", "l": "WNT5A binds FZD4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17822", "l": "hydrogen cyanide + L-cysteine => 3-cyano-L-alanine + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909721", "l": "Translocation of ISGF3 complex to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29909", "l": "glycerol + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-(1'-rac-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20651", "l": "cucurbitacin B + H(+) + NADPH => 23,24-dihydrocucurbitacin B + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36966", "l": "(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050600", "l": "acyl-CoA 11-(E)-desaturase activity", "d": ["Catalysis of the reaction: an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an (11E)-delta11-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333608", "l": "GSSebGalNac is reduced and methylated to MeSebGalNac (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42906", "l": "H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(748) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866304", "l": "pre-VLDL binds lipids to form VLDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854462", "l": "VLDLR binds VLDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58325", "l": "beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59207", "l": "docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70989", "l": "beta-alanine(in) + n H(+)(out) => beta-alanine(out) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43684", "l": "ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate = AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357445", "l": "PAK1-3 dimer disassociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651828", "l": "PARG dePARylates PARP1,PARP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019181", "l": "halohydrin hydrogen-halide-lyase activity", "d": ["Catalysis of the reaction: a halohydrin = an epoxide + a hydrogen halide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51236", "l": "GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n) = GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983424", "l": "Budding of COPII coated vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41259", "l": "L-tryptophan = (E)-3-(indol-3-yl)acrylate + NH4(+)", "d": []}, {"i": "EC:4.3.1.31", "l": "\"L-tryptophan ammonia lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768829", "l": "SRF stimulates NPAS4 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40479", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0016726", "l": "oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP."]}, {"i": "EC:1.17.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730848", "l": "Recruitment of GAB2 to PM and FCERI by binding to GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36157", "l": "A + Co-precorrin-4 + S-adenosyl-L-homocysteine => AH2 + Co(II)-factor III + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666178", "l": "RTKN binds RHOA, RHOC or RHOB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35587", "l": "FMN + H2O = phosphate + riboflavin", "d": []}, {"i": "EC:3.1.3.102", "l": "\"FMN hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160915", "l": "Receptor-mediated uptake of HA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21847", "l": "L-glutamine + phenylacetyl-CoA <=> CoA + H(+) + N(2)-phenylacetyl-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10727", "l": "GDP-6-deoxy-alpha-D-talose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38605", "l": "2'-phospho-cyclic ADP-ribose + nicotinamide => NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68636", "l": "(2E)-geranyl diphosphate = diphosphate + sabinene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75618", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate <=> ectocarpin B + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58284", "l": "5,6-dihydrothymine + NADP(+) = H(+) + NADPH + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15216", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA <=> (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75063", "l": "chloride(out) + 2 hydrogencarbonate(in) + Li(+)(in) = chloride(in) + 2 hydrogencarbonate(out) + Li(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35976", "l": "2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 => A + CO2 + H2O + succinate + verruculogen", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001002", "l": "RNA polymerase III type 1 promoter sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786854", "l": "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44417", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14711", "l": "a 3-oxo-Delta(4)-steroid => a 3-oxo-Delta(5)-steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070917", "l": "inositol phosphoceramide synthase regulator activity", "d": ["Binds to and modulates the activity of inositol phosphoceramide synthase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850961", "l": "PREX2 binds PTEN and inhibits it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186819", "l": "SH2 domain of Src binds to the active receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807565", "l": "GNLY is transferred to the phagosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12344", "l": "(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH", "d": []}, {"i": "EC:1.2.1.70", "l": "\"glutamyl-tRNA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50853", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51393", "l": "(9Z)-octadecenoyl-CoA + serotonin => CoA + H(+) + N-(9Z-octadecenoyl)-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047772", "l": "carboxymethyloxysuccinate lyase activity", "d": ["Catalysis of the reaction: carboxymethoxysuccinate = fumarate + glycolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694428", "l": "LMAN family proteins bind glycosylated cargo (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55141", "l": "D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] => AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538891", "l": "CLK:CYC heterodimer dissociates from per, tim, vri, and Pdp1 genes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35412", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside => an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside] + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31290", "l": "H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA <=> acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43309", "l": "1-hexadecanoyl-sn-glycerol + ATP => 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419389", "l": "LPA-binding receptors bind LPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102241", "l": "soyasaponin III rhamnosyltransferase activity", "d": ["Catalysis of the reaction: UDP-L-rhamnose + soyasaponin III <=> H+ + UDP + soyasaponin I."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654422", "l": "Activated FGFR4 binds FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76029", "l": "(S)-6-O-demethylreticuline + CO2 + formaldehyde + succinate => (S)-reticuline + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019727", "l": "mevaldate reductase (NAD+) activity", "d": ["Catalysis of the reaction: (R)-mevalonate + NAD+ = H+ + mevaldate + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20803", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769949", "l": "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19735", "l": "bacteriochlorophyllide a + H(+) + NADH => 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879562", "l": "SLCO2B1 has a narrow substrate specificity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23907", "l": "an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] <=> 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874979", "l": "ACBD3 binds GOLGB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18503", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH => ergosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31951", "l": "9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.111", "l": "\"9beta-pimara-7,15-diene oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47733", "l": "cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66533", "l": "ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] => diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28617", "l": "(1Z,2S)-2-methylbutanal oxime <=> (2S)-2-methylbutanenitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4411402", "l": "Activation of NLK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18779", "l": "an alkane + Hg(2+) => an alkylmercury + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453818", "l": "Defective STRA6 does not transport atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784598", "l": "NPPA(124-151) binds NPR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74710", "l": "fumagillol + NADP(+) <=> 5-dehydrofumagillol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12503", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) <=> 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71255", "l": "3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051779", "l": "gibberellin 12-aldehyde oxidase activity", "d": ["Catalysis of the reaction: gibberellin 12-aldehyde + NADPH + H+ + O2 = gibberellin 12 + NADP+ + H2O. This is the third of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451819", "l": "YKI binds to HTH and TSH and activates transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60065", "l": "a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44687", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424485", "l": "Release of p-PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013143", "l": "RAC1 GEFs activate RAC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45130", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944219", "l": "Association of procollagen type XVI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40207", "l": "(2E)-tetradecenedioyl-CoA + H2O = (3S)-hydroxytetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52903", "l": "3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide <=> 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675431", "l": "PP2A dephosphorylates RAF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19801", "l": "(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate", "d": []}, {"i": "EC:2.7.7.3", "l": "\"pantetheine-phosphate adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858500", "l": "CLEC10A binds Tn-MUC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29345", "l": "L-aspartate(out) + succinate(in) => L-aspartate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209960", "l": "Diiodinated tyrosine can be deiodinated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48815", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951499", "l": "Loading of antigenic peptides on to class I MHC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022897", "l": "proton-dependent peptide secondary active transmembrane transporter activity", "d": ["Enables the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428536", "l": "ARHGAP39 (Vilse) binds ROBO1:SLIT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977363", "l": "Factor H binds to C3bBb (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44032", "l": "9,10-epoxy-(12Z)-octadecenoate + H2O = 9,10-dihydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46000", "l": "adenosine + H(+) + tuberculosinyl diphosphate = 1-tuberculosinyladenosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450533", "l": "PKCdelta phosphorylates HuR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63511", "l": "a 1,2-saturated fatty acid + O2 <=> a (2R)-2-hydroperoxy fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66212", "l": "asc-omegaC5-CoA + O2 = asc-omegaDeltaC5-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042020", "l": "interleukin-23 receptor activity", "d": ["Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74567", "l": "L-glutamate(in) + N-acetyl-L-cysteine(out) = L-glutamate(out) + N-acetyl-L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71431", "l": "3,3',5'-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) = 3,3',5'-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.325", "l": "\"juvenile hormone-III synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199131", "l": "PVR binds CD226 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36370", "l": "(S)-alpha-hydroxyglutarate-gamma-lactone + H2O <=> 2-hydroxyglutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0003950", "l": "NAD+ ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30798", "l": "2-oxoadipate + CoA + NAD(+) <=> CO2 + glutaryl-CoA + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25948", "l": "a 1,2-diacyl-sn-glycerol + CTP = a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)", "d": []}, {"i": "EC:2.7.1.174", "l": "\"diacylglycerol kinase (CTP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038147", "l": "C-X-C motif chemokine 12 receptor activity", "d": ["Combining with the C-X-C motif chemokine 12 (CXCL12) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34254", "l": "1-deoxysphinganine + NADP(+) <=> 1-deoxy-3-dehydrosphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.36", "l": "\"sn-1 acyl-lipid omega-3 desaturase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74857", "l": "(R)-salsolinol-1-carboxylate + H2O => dopamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614933", "l": "ACEIs bind ACE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58260", "l": "H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] = ADP-D-ribose + L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004839", "l": "ubiquitin activating enzyme activity", "d": ["Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018758", "l": "RHOH binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65943", "l": "(R)-glycerate + GDP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953339", "l": "DNPH1 hydrolyses dGMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27932", "l": "(R)-4'-phosphopantothenate + AMP + diphosphate + H(+) => (R)-4-phosphopantoate + ATP + beta-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18011", "l": "CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein] => glutaryl-CoA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24616", "l": "17beta-estradiol + NADP(+) = estrone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388900", "l": "Neurotensin receptors can bind neurotensins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51056", "l": "A + androst-4-ene-3,17-dione = AH2 + androsta-1,4-diene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.1.3", "l": "\"NAD(P)(+) transhydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986480", "l": "IL26:IL20RA:JAK1 binds IL10RB:TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0050115", "l": "myosin-light-chain-phosphatase activity", "d": ["Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209823", "l": "Tyrosine is hydroxylated to dopa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12966", "l": "ATP + D-galacturonate => 1-phospho-alpha-D-galacturonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.-", "l": "\"CoA-transferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050042", "l": "lactate-malate transhydrogenase activity", "d": ["Catalysis of the reaction: (S)-lactate + oxaloacetate = malate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917987", "l": "TFRC dimer binds 2xholoTF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73260", "l": "cirsiliol + S-adenosyl-L-methionine => eupatorin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42070", "l": "clavulanate + NADP(+) => (3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22523", "l": "all-trans-retinal + H2O + O2 <=> all-trans-retinoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67914", "l": "1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid => [protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17199", "l": "2 4-hydroxyphenylacetate + 2 CO2 => 2 3-(4-hydroxyphenyl)pyruvate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102063", "l": "beta-curcumene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + (-)-beta-curcumene."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050075", "l": "maleate hydratase activity", "d": ["Catalysis of the reaction: (R)-malate = H2O + maleate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44669", "l": "4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol => 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60360", "l": "FMN + H(+) + oxidized coenzyme F420-0 = dehydro coenzyme F420-0 + FMNH2", "d": []}, {"i": "EC:1.3.8.17", "l": "\"dehydro coenzyme F420 reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944255", "l": "Association of procollagen type VII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18200", "l": "N-cyclohexylformamide <=> cyclohexyl isocyanide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40057", "l": "2,3-dioctanoyl-sn-glycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164832", "l": "ATPase synthesizes ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042809", "l": "nuclear vitamin D receptor binding", "d": ["Binding to a nuclear vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2129362", "l": "Fibrillin microfibril assembly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032781", "l": "WWTR1 (TAZ) binds TEAD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949580", "l": "F1Fo ATP synthase dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57082", "l": "1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione => glutathione + S-methyl-1-thio-D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46886", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.-", "l": "\"Phosphoric diester hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374683", "l": "Interaction of L1 with Neurocan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847968", "l": "PTEN binds FRK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862700", "l": "CMKLR1 binds Resolvin E1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51187", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + H2O <=> H(+) + octadecanoate + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168638", "l": "Activated IKK phosphorylates I-kappaB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189069", "l": "sucrose + H2O => glucose + fructose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604328", "l": "AKT1 phosphorylates NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665701", "l": "Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72672", "l": "The 60S subunit joins the translation initiation complex  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050399", "l": "xanthommatin reductase activity", "d": ["Catalysis of the reaction: 5,12-dihydroxanthommatin + NAD+ = H+ + NADH + xanthommatin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41901", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] => 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74708", "l": "fumagillol + NADP(+) => 5-dehydrofumagillol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56475", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63191", "l": "3,4-dihydroxybenzaldehyde + AH2 + tyramine <=> A + H2O + norbelladine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042806", "l": "fucose binding", "d": ["Binding to fucose, the pentose 6-deoxygalactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56213", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48865", "l": "2-methylpropan-1-amine + FADH2 + O2 => FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2529020", "l": "CK2 phosphorylates condensin I subunits (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11013", "l": "H2O + L-tryptophanamide => L-tryptophan + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65845", "l": "ADP(out) + H(+)(out) + phosphate(in) => ADP(in) + H(+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32489", "l": "CMP + 2 H(+) + phosphocholine => CDP-choline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008716", "l": "D-alanine-D-alanine ligase activity", "d": ["Catalysis of the reaction: 2 D-alanine + ATP = D-alanyl-D-alanine + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983285", "l": "RAD51B binds RAD51C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28496", "l": "a menaquinol + dimethyl sulfoxide => a menaquinone + dimethyl sulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51268", "l": "norbelladine + S-adenosyl-L-methionine = 4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.336", "l": "\"norbelladine O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60226", "l": "2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23339", "l": "2 H(+) + H2O2 + 2 iodide <=> diiodine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29530", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46531", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66128", "l": "2-oxobutanoate + L-phenylalanine = (2S)-2-aminobutanoate + 3-phenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60085", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) => a 4alpha-methyl-3-oxosteroid + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35115", "l": "4-coumaroyl-CoA + H(+) + malonyl-CoA = (4-coumaroyl)acetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22382", "l": "[(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol => [(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9671145", "l": "DKC1 binds SHQ1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74116", "l": "an anthocyanidin + UDP-alpha-D-galactose => an anthocyanidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62407", "l": "(R)-2-hydroxyhexadecanoate + O2 <=> CO2 + H2O + pentadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9609921", "l": "SGTA binds Tail-anchored protein (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.5", "l": "\"dynamin GTPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65631", "l": "sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008043", "l": "MAPK8 phosphorylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21062", "l": "CoA + N-(3,4-dichlorophenyl)malonamate => 3,4-dichloroaniline + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55303", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44774", "l": "2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+) => 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47008", "l": "[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51185", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + H2O => H(+) + octadecanoate + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52054", "l": "9-hydroxy-octadecanoate + H(+) + hexadecanoate => 9-hexadecanoyloxy-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.27", "l": "\"sphinganine-1-phosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53739", "l": "a 2-halobenzoate + H(+) + NADH + O2 <=> a halide anion + catechol + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66625", "l": "cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => (25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373716", "l": "DCC interacting NCK-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9658253", "l": "RAS:GTP binds PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63756", "l": "flavokermesate + UDP-alpha-D-glucose = flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31818", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-(E)-beta-caryophyllene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851038", "l": "BTN3A1 binds prenylated phosphoantigens (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210300", "l": "Interaction of DAP12 and TREM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62558", "l": "4-methylcatechol + CO2 => 3,4-dihydroxyphenylacetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676133", "l": "CD74 binds MIF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454928", "l": "ABCG4 may mediate cholesterol efflux (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2995388", "l": "PP2A dephosphorylates BANF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54708", "l": "N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36838", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23880", "l": "L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate", "d": []}, {"i": "EC:2.7.3.9", "l": "\"phosphoenolpyruvate--protein phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12137", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) => a (2E,4E)-dienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10549", "l": "L-arginine + O2 => 4-guanidinobutanamide + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20141", "l": "an S-alkyl-L-cysteine S-oxide = 2-aminoprop-2-enoate + an S-alkyl sulfenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373087", "l": "Receptor CCR6 binds CCL20 ligand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69826", "l": "(22S)-22-hydroxycampest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59170", "l": "AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase] => ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015055", "l": "secretin receptor activity", "d": ["Combining with secretin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102788", "l": "4-coumaroyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + pelargonidin 3-O-beta-D-glucoside = pelargonidin 3-O-beta-D-p-coumaroylglucoside + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45761", "l": "dTDP-beta-L-daunosamine + epsilon-rhodomycinone => dTDP + H(+) + rhodomycin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983158", "l": "Trimming of peptides in ER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53815", "l": "cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050133", "l": "N6-hydroxylysine O-acetyltransferase activity", "d": ["Catalysis of the reaction: N(6)-hydroxy-L-lysine + acetyl-CoA = N(6)-acetyl-N(6)-hydroxy-L-lysine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867041", "l": "EGFR phosphorylates EPS15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41450", "l": "(4S)-4-hydroxy-L-isoleucine + CO2 + succinate => 2-oxoglutarate + L-isoleucine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54061", "l": "(2E,6E)-farnesyl diphosphate + H2O => (2Z,6E)-hedycaryol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69648", "l": "H2O + quercetin 4'-O-beta-D-glucoside => beta-D-glucose + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57722", "l": "ADP + 5 H(+)(out) + phosphate => ATP + 4 H(+)(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47870", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => di-(9Z)-octadecenoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2545253", "l": "Deacetylation of cohesin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692880", "l": "HRH3 binds Hist (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37060", "l": "adenosine(37) in tRNA + L-threonylcarbamoyladenylate => AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001072", "l": "galactomannan binding", "d": ["Binding to galactomannan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40493", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) => 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30384", "l": "(2E,6E)-farnesyl diphosphate => (-)-7-epi-alpha-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70450", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + O2 <=> a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31337", "l": "diphosphate + Mo-molybdopterin cytosine dinucleotide => CTP + H(+) + Mo-molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696564", "l": "USP25 deubiquitinates DDX58 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9608039", "l": "NR1H2,3 binds the PLIN1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13418", "l": "5,12-dihydroxanthommatin + NAD(+) => H(+) + NADH + xanthommatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2399913", "l": "atRAL binds to RBP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182263", "l": "Degradation of MHC I Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805122", "l": "AURKB binds TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58414", "l": "H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin] => 3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56955", "l": "CTP + pyruvate <=> CDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27805", "l": "(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate <=> all-trans-decaprenyl diphosphate + 7 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37954", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688786", "l": "ATXN3 binds RAD23 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33716", "l": "4-hydroxyeicosasphinganine 1-phosphate => 2-hydroxyoctadecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803400", "l": "TP53 stimulates PCBP4 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49865", "l": "(+)-dehydrodiconiferyl acid + 2 a quinone + H2O => (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10401", "l": "L-glutamine + pyruvate => 2-oxoglutaramate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2248891", "l": "Active ARSA translocates to the lysosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187213", "l": "Synthesis of GAG polyprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39867", "l": "3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol = 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14548", "l": "H2O + nicotinamide <=> NH4(+) + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210700", "l": "KEN dimer represses transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685655", "l": "CTSL bind CTSL inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140946", "l": "histone H3K4 dimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl4-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl4-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65318", "l": "chrodrimanin E + CO2 + H2O + succinate => 2-oxoglutarate + chrodrimanin H + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36620", "l": "2-hydroxydocosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41546", "l": "8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine => 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74698", "l": "(+)-exo-beta-bergamotene + O2 + reduced [NADPH--hemoprotein reductase] <=> (5R)-hydroxy-beta-trans-bergamotene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72554", "l": "glutarate(out) + urate(in) <=> glutarate(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46754", "l": "7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700154", "l": "Active ALK binds SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49213", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24267", "l": "D-xylulose 5-phosphate + formaldehyde <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-994148", "l": "LRRC16A binds F-actin capping protein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205238", "l": "SHP2 interacts with p-KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36519", "l": "H(+) + hexacosanoyl-CoA + malonyl-CoA = 3-oxooctacosanyol-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70228", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA => (E)-2-benzylidenesuccinyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46385", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49741", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate => CO2 + deoxyviolacein + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66902", "l": "CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O => acetyl-CoA + L-tryptophan + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75593", "l": "(11S)-hydroxy-(9S,10S)-epoxy-(12Z)-octadecenoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021609", "l": "ESR-associated SRC autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73049", "l": "guanidinoacetate(out) => guanidinoacetate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404193", "l": "IGF1R phosphorylates SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32605", "l": "(6E)-8-oxogeraniol + H(+) + NADPH => (6E)-8-hydroxygeraniol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22174", "l": "H(+) + sucrose 6(F)-phosphate + UDP => beta-D-fructose 6-phosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72401", "l": "2-oxoglutarate(in) + estrone 3-sulfate(out) => 2-oxoglutarate(out) + estrone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75497", "l": "n H(+)(in) + pregnenolone sulfate(in) => n H(+)(out) + pregnenolone sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12026", "l": "D-glucose + O-sinapoylcholine => 1-O-(trans-sinapoyl)-beta-D-glucose + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014652", "l": "Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804879", "l": "MDM2 ubiquitinates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159868", "l": "Furin cleaves pro-factor VII to factor VII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68456", "l": "(S)-3-hydroxyglutaryl-CoA = (2E)-glutaconyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9726580", "l": "PGR binds PGR agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20216", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein] <=> L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047642", "l": "aldose beta-D-fructosyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-aldosyl1 beta-D-fructoside + D-aldose2 = D-aldose1 + alpha-D-aldosyl2 beta-D-fructoside."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050639", "l": "10-hydroxytaxane O-acetyltransferase activity", "d": ["Catalysis of the reaction: 10-desacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432121", "l": "LDL binds to LRP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176452", "l": "Degradation of ubiquitinated SMAD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814831", "l": "TBC1D20 binds RAB1:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65296", "l": "(2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052913", "l": "16S rRNA (guanine(966)-N(2))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(966) in 16S rRNA = N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033130", "l": "acetylcholine receptor binding", "d": ["Binding to an acetylcholine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417122", "l": "Elongation and translocation of the telomeric chromosome end (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74835", "l": "UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-galactosamine(in) = UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-galactosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62788", "l": "2 fonsecin B + H(+) + NADPH + O2 = aurasperone B + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35208", "l": "H2O + IDP => H(+) + IMP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5658435", "l": "RAS GAPs bind RAS:GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30621", "l": "2 AH2 + all-trans-lycopene => 2 A + all-trans-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031836", "l": "neuromedin K receptor binding", "d": ["Binding to a neuromedin K receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047159", "l": "1-alkenylglycerophosphocholine O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-alkenylglycerophosphocholine + acyl-CoA = 1-alkenyl-2-acylglycerophosphocholine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38608", "l": "2'-phospho-cyclic ADP-ribose + nicotinate => nicotinate-adenine dinucleotide phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71578", "l": "5-phosphomethyl-dUMP in DNA + putrescine <=> 5-N(alpha)-putrescinyl-dTMP in DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031840", "l": "type 2 neuromedin U receptor binding", "d": ["Binding to a type 2 neuromedin U receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848606", "l": "PTK6 phosphorylates PXN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19606", "l": "a chlorophyll + H2O => a chlorophyllide + H(+) + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55294", "l": "H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine => pseudouridine(54) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40297", "l": "AMP + diphosphate + hexadecanedioyl-CoA => ATP + CoA + hexadecanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374681", "l": "L1 and NCAM1 engaged in cis-interaction (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74360", "l": "coproporphyrin I(out) => coproporphyrin I(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951727", "l": "cAMP binds PKA tetramer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010291", "l": "carotene beta-ring hydroxylase activity", "d": ["Catalysis of the reaction: a carotene + a reduced electron acceptor + O2 = C3-hydroxylated carotene + an oxidized electron acceptor + H2O. This is a general reaction to represent the C3 hydroxylation of the beta ring of a carotene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72647", "l": "1,6-dihydroxyphenazine + NADPH + O2 = 1,6-dihydroxyphenazine N(5)-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190256", "l": "FGFR1c binds to FGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008884", "l": "glutathionylspermidine amidase activity", "d": ["Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032548", "l": "pyrimidine deoxyribonucleoside binding", "d": ["Binding to a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102194", "l": "protein-fructosamine 3-kinase activity", "d": ["Catalysis of the reaction: ATP + a [protein]-N6-D-fructosyl-L-lysine <=> ADP + H+ + a [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73710", "l": "ATP(in) + UDP(out) <=> ATP(out) + UDP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38411", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69649", "l": "beta-D-glucose + quercetin => H2O + quercetin 4'-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473584", "l": "Collagen type III degradation by MMP15 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866851", "l": "CFTR transits to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173709", "l": "C7 binds C5b:C6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.19", "l": "\"cis-1,2-dihydrobenzene-1,2-diol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627078", "l": "XIAP binds CASP9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017120", "l": "IK1 binds the PTCRA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375395", "l": "C5a receptor binds C5a anaphylatoxin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19497", "l": "H(+) + L-aspartate = beta-alanine + CO2", "d": []}, {"i": "EC:4.1.1.11", "l": "\"aspartate 1-decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11342", "l": "4-guanidinobutanal + CO2 => 5-guanidino-2-oxopentanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34794", "l": "2-hydroxyethylphosphonate + O2 <=> formate + H(+) + hydroxymethylphosphonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21409", "l": "H2O + L-phenylalanine + NAD(+) => 3-phenylpyruvate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027425", "l": "LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29588", "l": "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) => 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202111", "l": "AKT1 phosphorylates eNOS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32896", "l": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] => 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51069", "l": "(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate => (3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44757", "l": "2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2203480", "l": "COLEC11 binds ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392513", "l": "Rap1 signal termination by Rap1GAPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65801", "l": "a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O => a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27984", "l": "7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate => 7-carboxy-7-deazaguanine + ATP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0052590", "l": "sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + a ubiquinone = glycerone phosphate + a ubiquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15376", "l": "columbamine + S-adenosyl-L-methionine <=> H(+) + palmatine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354060", "l": "Translocation of RIAM to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938356", "l": "RMB14 binds RUNX2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17704", "l": "ATP + geranoyl-CoA + hydrogencarbonate <=> 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450488", "l": "BRF1 Complex recruits RNA degradation activities (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74468", "l": "a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + H2O => a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69798", "l": "D-aspartyl-tRNA(Asp) + H2O <=> D-aspartate + H(+) + tRNA(Asp)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001055", "l": "RNA polymerase II activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67372", "l": "H2O + L-seryl-L-threonine = L-serine + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374298", "l": "Opioid receptors bind opioid peptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786101", "l": "IL4 binds IL4R:JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17487", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70287", "l": "1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73905", "l": "ADP + gamma-L-glutamylethanolamide + H(+) + phosphate => ATP + ethanolamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14177", "l": "(R)-amygdalin + H2O = (R)-prunasin + D-glucose", "d": []}, {"i": "EC:3.2.1.117", "l": "\"amygdalin beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42138", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33728", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine => a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103102", "l": "UDP-glucose:8-methylthiooctylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 8-methylthiooctylhydroximate <=> H+ + 7-methylthioheptyldesulfoglucosinolate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617815", "l": "BBSome binds RAB3IP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191654", "l": "c-src associates with Cx43 in gap junctions (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65731", "l": "2-oxoglutarate + hexyl sulfate + O2 <=> CO2 + H(+) + hexanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55810", "l": "a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O => a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60004", "l": "(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10385", "l": "cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate => beta-cyclopiazonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62473", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37722", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14396", "l": "N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31895", "l": "(2E,6E)-farnesyl diphosphate = alpha-humulene + diphosphate", "d": []}, {"i": "EC:4.2.3.104", "l": "\"alpha-humulene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75634", "l": "H2O + plasmodiophorol B <=> plasmodiophorol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26227", "l": "abieta-7,13-dien-18-oate + 2 H(+) + NADH => abieta-7,13-dien-18-al + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31011", "l": "(S)-2,3-epoxysqualene = camelliol C", "d": []}, {"i": "EC:5.4.99.38", "l": "\"camelliol C synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.652932776586212", "identifiers": [{"i": "GO:0046912", "l": "acyltransferase activity, acyl groups converted into alkyl on transfer", "d": ["Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer."]}, {"i": "EC:2.3.3.-", "l": "\"Acyl groups converted into alkyl groups on transfer\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26518", "l": "3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27453", "l": "iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139909", "l": "Translocation of BMF to mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.41", "l": "\"3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27368", "l": "bromide + S-adenosyl-L-methionine <=> bromomethane + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34523", "l": "[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose = [alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.293", "l": "\"GalNAc5-diNAcBac-PP-undecaprenol beta-1,3-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51244", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47406", "l": "3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH => (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67008", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.56", "l": "\"mRNA (guanine-N(7))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205321", "l": "Interaction of KIT and sSCF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23290", "l": "acetyl-CoA + H(+) + NADH => acetaldehyde + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77077", "l": "Capping complex formation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28193", "l": "2'-deoxyadenosine + H(+) + H2O <=> 2'-deoxyinosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40845", "l": "(2E)-octadecenoyl-CoA + FADH2 => FAD + H(+) + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28782", "l": "4-hydroxy-L-threonine <=> glycine + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67427", "l": "a glycerophospholipid + H2O <=> a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102369", "l": "11alpha-30-dihydroxy beta-amyrin dehydrogenase activity", "d": ["Catalysis of the reaction: 11alpha,30-dihydroxy-beta-amyrin + NADPH + O2 + H+ <=> 30-hydroxy-11-oxo-beta-amyrin + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111238", "l": "Formation of ADAR2  homodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65320", "l": "2-oxoglutarate + chrodrimanin E + O2 = chrodrimanin A + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64361", "l": "(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 => (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21813", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0003975", "l": "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733545", "l": "Bile salts and acids bind ALB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59852", "l": "(2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH = (R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15643", "l": "CO2 + pyruvate => H(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675417", "l": "PEBP1 binds activated RAF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36203", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781009", "l": "NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74696", "l": "(+)-exo-beta-bergamotene + O2 + reduced [NADPH--hemoprotein reductase] => (5R)-hydroxy-beta-trans-bergamotene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201629", "l": "Caspase-mediated cleavage of Tau (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13543", "l": "H(+) + sulfate + sulfur + thiosulfate => H2O + tetrathionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75984", "l": "(indol-3-yl)acetate(out) + a dicarboxylate(in) => (indol-3-yl)acetate(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69606", "l": "UTP <=> 3',5'-cyclic UMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56062", "l": "CO2 + pentadecane => H(+) + hexadecanoate + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53060", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.10", "l": "\"4,4'-diapolycopenoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380586", "l": "loading of Serotonin in synaptic vesicles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39268", "l": "(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3857336", "l": "CEBPB homodimerization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67050", "l": "A + asnovolin I + H2O => AH2 + chermesin D + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25174", "l": "H2O + N(omega)-methyl-L-arginine => L-citrulline + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818578", "l": "Cleaved KMT2B dimers translocate to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990808", "l": "F-bar domain binding", "d": ["Binding to an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45805", "l": "ATP + hydroxylamine + L-glutamate => ADP + L-glutamine hydroxamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38756", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.12", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61420", "l": "(S)-8-oxocitronellyl enol = cis-cis-nepetalactol", "d": []}, {"i": "EC:5.5.1.35", "l": "\"(+)-cis,cis-nepetalactol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9733973", "l": "Bile salts bind FABP6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627056", "l": "Procaspase 9 forms dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63767", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61950", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102213", "l": "in-chain hydroxy fatty acyl-CoA synthetase activity", "d": ["Catalysis of the reaction: coenzyme A + ATP + an in-chain hydroxy fatty acid = diphosphoric acid + AMP + a in-chain hydroxyacyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782138", "l": "ERCC5 and RPA bind TC-NER site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729481", "l": "SARS-CoV-2 N binds to G3BP1,G3BP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928656", "l": "gamma-secretase cleaves EPHB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52547", "l": "D-erythronate + NAD(+) <=> 2-dehydro-D-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55229", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74215", "l": "H2O + L-seryl-tRNA(Lys) = L-serine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863973", "l": "Fusion of ERC and phagosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001071", "l": "maltoheptaose binding", "d": ["Binding to maltoheptaose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653622", "l": "Defective SLC35A3 does not exchange UDP-GlcNAc for UMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66316", "l": "an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O = alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18084", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + pentalenene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72727", "l": "UDP-alpha-D-glucuronate(in) + UMP(out) = UDP-alpha-D-glucuronate(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20289", "l": "acetyl-CoA + H2O = acetate + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.1", "l": "\"acetyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46540", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534365", "l": "Slo3 Potassium Transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-380930", "l": "Phosphorylated AMPK binds AMP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033434", "l": "AUC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AUC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60409", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O => Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69619", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050644", "l": "cis-p-coumarate glucosyltransferase activity", "d": ["Catalysis of the reaction: cis-4-coumarate + UDP-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23515", "l": "alpha,alpha-trehalose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685319", "l": "CX3 complex formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73800", "l": "dimethylallyl diphosphate + isoechinulin A => dehydroechinulin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73386", "l": "thiamine diphosphate(in) + thiamine phosphate(out) <=> thiamine diphosphate(out) + thiamine phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0004346", "l": "glucose-6-phosphatase activity", "d": ["Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37464", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603784", "l": "PEX19:class I PMP binds PEX3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052817", "l": "very long chain acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: H2O + a very long chain acyl-CoA = a very long chain carboxylate + CoA. A very long chain has chain length greater than C18."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736966", "l": "SMAD7 binds SERPINE1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24814", "l": "2-oxoglutarate + L-valine => 3-methyl-2-oxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21651", "l": "H(+) + prephenate <=> 3-phenylpyruvate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694441", "l": "CSNK1D phosphorylates SEC23 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10841", "l": "H2O + O-phospho-L-homoserine => L-threonine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033200", "l": "inositol heptakisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: ATP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, and ATP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549129", "l": "OCT1 transports organic cations into hepatic cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30709", "l": "4-aminobutanal + L-alanine => putrescine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61823", "l": "3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose <=> epiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69434", "l": "3 [thioredoxin]-disulfide + 3 glutathione + 3 H(+) + 3 S-adenosyl-L-homocysteine + trimethylarsine => 3 [thioredoxin]-dithiol + arsenic triglutathione + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070284", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity", "d": ["Catalysis of the reaction: 5-aminoimidazole ribonucleotide + S-adenosylmethionine = 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate + 5'deoxyadenosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44827", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14278", "l": "(S)-lactaldehyde + H2O + NAD(+) => (S)-lactate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62127", "l": "a 2'-deoxyribonucleoside 5'-phosphate + GTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22207", "l": "3-hydroxyphenylacetate + H(+) + NADPH + O2 <=> H2O + homogentisate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932076", "l": "AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.49", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40411", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58834", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17064", "l": "H(+) + NADPH + O2 + phenol <=> catechol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14430", "l": "a [oligopeptide](in) + ATP + H2O => a [oligopeptide](out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27900", "l": "adenosine + phosphate => 3'-AMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374673", "l": "L1 binds RanBPM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75011", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate = 9-(9Z-octadecenoyloxy)-octadecanoate + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62801", "l": "2 7-demethylsiderin + NADPH + O2 => 2 H2O + NADP(+) + orlandin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570528", "l": "SUMOylation of XPC with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161949", "l": "HXA3/B3 is hydrolysed to TrXA3/B3 by HXEH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54166", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16894", "l": "pyridine + S-adenosyl-L-methionine => N-methylpyridinium + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9716913", "l": "ESR1 binds ESR1 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25826", "l": "H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine => H2O + O2 + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373087", "l": "Receptor CCR6 binds CCL20 ligand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28873", "l": "D-fructuronate(out) + H(+)(out) => D-fructuronate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001962", "l": "alpha-1,3-galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43678", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10752", "l": "[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate", "d": []}, {"i": "EC:6.3.1.12", "l": "\"D-aspartate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58486", "l": "acetate + sphing-4-enine => H2O + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69772", "l": "a short-chain fatty aldehyde + H2O + NAD(+) => a short-chain fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71460", "l": "H2O + substance P => L-Leu-L-Met-NH2 + substance P(1-9)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193655", "l": "Myelin components can interact with p75NTR:NgR:LINGO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228407", "l": "tetX HC:LC binds target cell-surface gangliosides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31786", "l": "H2O + tuberculosinyl diphosphate <=> diphosphate + tuberculosinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849908", "l": "SALM4 binds flotillin-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964759", "l": "Alternative endo-mannosidase I route (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52604", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP = 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791348", "l": "TP53 stimulates APAF1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14086", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA => 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0004673", "l": "protein histidine kinase activity", "d": ["Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35472", "l": "(+)-6a-hydroxymaackiain + S-adenosyl-L-methionine => (+)-pisatin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36742", "l": "heptadecasphing-4-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40792", "l": "H2O + hexacosanoyl-CoA => CoA + H(+) + hexacosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54710", "l": "H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140346", "l": "phosphatidylserine flippase activity", "d": ["Catalysis of the movement of phosphatidylserine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444792", "l": "Calmodulin-bound CaMKII-gamma enters the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63034", "l": "a fatty acid + NH4(+) => a fatty acylamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47657", "l": "acetyl-CoA + L-methionine sulfone => CoA + H(+) + N-acetyl-L-methionine sulfone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49756", "l": "H(+) + O2 + protoviolaceinate = CO2 + H2O + proviolacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353504", "l": "Insertion of correct bases opposite to the lesion by Pol eta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45541", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004333", "l": "fumarate hydratase activity", "d": ["Catalysis of the reaction: (S)-malate = fumarate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28171", "l": "(2R)-2-hydroxy-2-methylbutanenitrile => butan-2-one + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77077", "l": "Capping complex formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53107", "l": "4-hydroxyestrone + S-adenosyl-L-methionine <=> 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448629", "l": "IL33 binds IL1RL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702638", "l": "tandutinib-resistant FLT3 mutants don't bind tandutinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23241", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65603", "l": "4,5,8-trihydroxycasbene + 2 NAD(+) <=> 2 H(+) + jolkinol C + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351901", "l": "Caspase-mediated cleavage of MST3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54736", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56748", "l": "an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38408", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34689", "l": "A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine => AH2 + N-acyl-15-methylhexadecasphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201639", "l": "Caspase-mediated cleavage of GAS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0034185", "l": "apolipoprotein binding", "d": ["Binding to an apolipoprotein, the protein component of a lipoprotein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12084", "l": "D-mannitol + NAD(+) = D-fructose + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.67", "l": "\"mannitol 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977363", "l": "Factor H binds to C3bBb (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61696", "l": "ATP + glycine + holo-[peptidyl-carrier protein] = AMP + diphosphate + glycyl-[peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.66", "l": "\"glyine--[glycyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72635", "l": "1-hydroxy-6-methoxyphenazine N(10)-oxide + S-adenosyl-L-methionine = 1,6-dimethoxyphenazine N(5)-oxide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50328", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13416", "l": "ADP + thymidine <=> AMP + dTMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030229", "l": "very-low-density lipoprotein particle receptor activity", "d": ["Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814555", "l": "Integrator complex processes the 3' end of snRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57265", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP => GDP + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062145", "l": "L-propargylglycine--L-glutamate ligase activity", "d": ["Catalysis of the reaction: ATP + L-glutamate + L-propargylglycine = ADP + H+ + L-gamma-glutamyl-L-propargylglycine + phosphate."]}, {"i": "RHEA:59896", "l": "ATP + L-glutamate + L-propargylglycine = ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13082", "l": "biotin amide + H2O => biotin + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60126", "l": "diphosphate + sodorifen => pre-sodorifen diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14625", "l": "[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) = [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)", "d": []}, {"i": "EC:2.4.1.2", "l": "\"dextrin dextranase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199910", "l": "MSK1 activates ATF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46966", "l": "2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate => lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18320", "l": "an L-alpha-amino acid <=> a D-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59979", "l": "2-phenylacetate + H(+) <=> CO2 + toluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607721", "l": "Activation of NIK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65334", "l": "chrodrimanin E + H2O + NADP(+) => H(+) + NADPH + O2 + verruculide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48622", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421320", "l": "BMAL1:CLOCK,NPAS2 heterodimer is phosphorylated and translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72839", "l": "ADP(out) + CoA(in) = ADP(in) + CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33591", "l": "sphinganine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41735", "l": "[(1->4)-alpha-D-glucosyl](n) + phosphate <=> [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56724", "l": "AH2 + all-trans-beta-carotene + O2 = 4-hydroxy-all-trans-beta-carotene + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23787", "l": "a quinone + L-proline <=> (S)-1-pyrroline-5-carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047053", "l": "(S)-cheilanthifoline synthase activity", "d": ["Catalysis of the reaction: (S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-cheilanthifoline + [oxidized NADPH--hemoprotein reductase] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202472", "l": "Translocation of TRAF6 to CBM complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62589", "l": "2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) => 4-hydroxybenzyl alcohol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13344", "l": "a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51531", "l": "H(+) + vanillate <=> CO2 + guaiacol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.3.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74059", "l": "PDE6 hydrolyses cGMP to GMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944257", "l": "Association of procollagen type XXIV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8856951", "l": "PP2A demethylation by PPME1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848023", "l": "Activated PTK6 binds STAP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0018835", "l": "carbon phosphorus lyase activity", "d": ["Catalysis of the reaction: alkylphosphonic acid = R-CH3 + phosphate. Substrates include aminomethylphosphonic acid (AMPA) (forms methylamine), dimethylphosphinic acid (forms methylphosphonic acid), glyphosate (forms sarcosine) and methylphosphonic acid (forms phosphate)."]}, {"i": "EC:4.7.1.-", "l": "\"Carbon-phosphorus lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19285", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol = a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol", "d": []}, {"i": "EC:2.3.1.83", "l": "\"phosphatidylcholine--dolichol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25808", "l": "H2O + O2 + spermidine = 3-aminopropanal + H2O2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31339", "l": "acetate + ATP + holo-[ACP] = acetyl-[ACP] + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.35", "l": "\"acetate--[acyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980042", "l": "NOTCH1 binds JAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26080", "l": "methanesulfonate + NADH + O2 <=> formaldehyde + H2O + NAD(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17786", "l": "H(+) + L-glutamate => 4-aminobutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36244", "l": "(E)-anol + acetate + NADP(+) => (E)-coumaryl acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16876", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187382", "l": "Degradation of ubiquitinated SMAD3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72175", "l": "5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) = 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.20.5", "l": "\"flavone synthase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939335", "l": "RNF181 polyubiquinates BCL10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102839", "l": "1-18:2-2-16:2-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57620", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42273", "l": "3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] => 5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9658253", "l": "RAS:GTP binds PI3K (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948066", "l": "K63polyUb-IRAK1 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39415", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH = (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43043", "l": "hexadecanoyl-CoA + hexadecasphinganine <=> CoA + H(+) + N-hexadecanoylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297354", "l": "Acrosin Cleavage (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980122", "l": "DTX binds NOTCH1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74658", "l": "ITP + N-acetyl-D-glucosamine <=> H(+) + IDP + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864936", "l": "VEGFA gene expression is inhibited by the TFAP2A homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033410", "l": "UAC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UAC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669250", "l": "PAK1 phosphorylates FLNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14783", "l": "6-carboxyhexanoyl-CoA + AMP + diphosphate => ATP + CoA + heptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28339", "l": "(R)-carnitinyl-CoA => crotonobetainyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.3", "l": "\"aldose 1-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42719", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate <=> (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928604", "l": "SFKs phosphorylate VAV2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1467466", "l": "ABCA4 mediates atRAL transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36654", "l": "8-desmethylnovobiocic acid + S-adenosyl-L-methionine <=> H(+) + novobiocic acid + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873919", "l": "Phosphorylation of JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.41", "l": "\"xylogalacturonan beta-1,3-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41609", "l": "3'-phosphoadenylyl sulfate + alpha,alpha-trehalose => 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39269", "l": "(3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+) => (15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72702", "l": "acrylate + H(+) + NADH <=> NAD(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72321", "l": "n chloride(out) + urate(in) => n chloride(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60581", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37955", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61124", "l": "kaempferol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392263", "l": "AVP(20-28) binds AVPR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42155", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709268", "l": "Defective BRCA2 does not translocate to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45744", "l": "(6S)-5,6,7,8-tetrahydropteroate + NAD(+) = 7,8-dihydropteroate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18420", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> CMP + ganglioside GM3 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683593", "l": "ATG7:ATG3:LC3 dissociates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16042", "l": "[(1->3)-beta-D-glucosyl](n) + phosphate => [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72211", "l": "(+)-isoborneol + NAD(+) = (1S,4S)-camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781021", "l": "EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12385", "l": "5,6-dihydrouracil + O2 => H2O2 + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22723", "l": "ATP + L-histidyl-[protein] <=> ADP + H(+) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65221", "l": "(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+) => catechol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30442", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) <=> 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004594", "l": "pantothenate kinase activity", "d": ["Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38203", "l": "19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21142", "l": "ADP + H(+) + IMP => ATP + inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3134953", "l": "DHX36 or DHX9 binds MyD88 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46461", "l": "(22R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1810457", "l": "ZBP1(DAI) recruits RIP1 and RIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48735", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O <=> [CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195304", "l": "Association of beta-catenin with the destruction complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61892", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162194", "l": "COQ9 dimer:COQ7:Fe2+ hydroxylates DMQ10H2 to DeMQ10H2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196773", "l": "COASY phosphorylates DP-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20092", "l": "acetyl-CoA + L-leucine <=> CoA + H(+) + N-acetyl-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29423", "l": "ATP + diphosphate = ADP + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388833", "l": "Phosphorylation of CTLA-4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5195402", "l": "CDK1 phosphorylates LPIN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70692", "l": "ornithine => putrescine + CO2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683792", "l": "p-T68-CHEK2 autophosphorylates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770847", "l": "Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31953", "l": "9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47931", "l": "(2S)-3-sulfolactaldehyde + H2O + NADP(+) <=> (2S)-3-sulfolactate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12596", "l": "a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21966", "l": "a carboxylate + choline + H(+) => an acylcholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31700", "l": "4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] => 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24197", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) => (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981606", "l": "Myoglobin binds oxygen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66118", "l": "(2S)-2-aminobutanoate + 2-oxoglutaramate => 2-oxobutanoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17390", "l": "D-arabinitol + NAD(+) => D-ribulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71152", "l": "4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one => (E)-caffeoylpyruvate + CO2 + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33478", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17555", "l": "ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate => ATP + guanidinoethyl methyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23265", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+) => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40108", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008031", "l": "eclosion hormone activity", "d": ["The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54904", "l": "(2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH = (9Z)-hexadecenoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74258", "l": "XDH oxidizes xanthine to form urate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23758", "l": "dehydro-D-arabinono-1,4-lactone + H(+) + H2O2 => D-arabinono-1,4-lactone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66627", "l": "cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> (25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202174", "l": "Activation of ZAP-70 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850997", "l": "TRIM27 binds PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015124", "l": "allantoate transmembrane transporter activity", "d": ["Enables the transfer of allantoate from one side of a membrane to the other. Allantoate is the end product of purine metabolism in mammals and some fish, formed form allantoin. It is widely distributed in plants as an important source of stored nitrogen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9620456", "l": "sGC stimulators bind sGC:NO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868709", "l": "Maltose is converted to trehalose (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62575", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine <=> glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18178", "l": "a 2,3-saturated acyl-CoA + NAD(+) => a (2E)-enoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187586", "l": "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353476", "l": "Recruitment of repair factors to form the preincision complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25663", "l": "(2E)-geranyl diphosphate => alpha-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989768", "l": "Expression of TIAM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102940", "l": "phloroglucinol O-methyltransferase activity", "d": ["Catalysis of the reaction: phloroglucinol + S-adenosyl-L-methionine = H+ + 3,5-dihydroxyanisole + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0003747", "l": "translation release factor activity", "d": ["Involved in catalyzing the release of a nascent polypeptide chain from a ribosome."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0016918", "l": "retinal binding", "d": ["Binding to retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51349", "l": "acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine => 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665748", "l": "FMNL2 binds RHOC:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102835", "l": "1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27502", "l": "3',5'-di-O-methyltricetin + S-adenosyl-L-methionine => 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863012", "l": "Calpain cleaves p35 to p25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404193", "l": "IGF1R phosphorylates SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941895", "l": "Formation of CDK4/6:CCND complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69727", "l": "2-phenylacetate + ATP + H(+) = diphosphate + phenylacetyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429036", "l": "SLC2A9 transports Fru, Glc, urate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693243", "l": "RHOD translocates to the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13941", "l": "ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.28", "l": "\"triokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48967", "l": "2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 <=> [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44066", "l": "CoA + octyl hexadecanoyl => hexadecanoyl-CoA + octan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56573", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose => globoside Gb3Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50570", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29819", "l": "ATP + H2O + L-isoleucine(out) = ADP + H(+) + L-isoleucine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47577", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) => CMP + ganglioside GD1c (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437118", "l": "GPVI stimulates PI3K beta, gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852019", "l": "MET bound PI3K generates PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55636", "l": "ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0046921", "l": "alpha-(1->6)-fucosyltransferase activity", "d": ["Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618107", "l": "ATP binding to HSP90 triggers conformation change (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9732729", "l": "Activated JAK1 binds RAF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72679", "l": "(R)-dihydrolipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956568", "l": "RUNX1 binds the core TAL1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061749", "l": "forked DNA-dependent helicase activity", "d": ["Unwinding a DNA helix containing forked DNA, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50132", "l": "ethyl hexadecanoate + H2O = ethanol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48899", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a <=> 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11910", "l": "butanoate + H(+) + pentan-2-one => H2O + nonane-4,6-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.2", "l": "\"4-hydroxybenzoate 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23308", "l": "(E)-sinapoyl-CoA + D-glucarate = 2-O-[(E)-sinapoyl]-D-glucarate + CoA", "d": []}, {"i": "EC:2.3.1.131", "l": "\"glucarate O-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16176", "l": "(4-hydroxyphenyl)acetaldehyde + dopamine <=> (S)-norcoclaurine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23806", "l": "N-acetyl-D-glucosamine 6-phosphate => N-acetyl-alpha-D-glucosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70004", "l": "6-oxocampestanol + O2 + reduced [NADPH--hemoprotein reductase] => cathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061898", "l": "all-trans retinoic acid 3,4-desaturase activity", "d": ["Catalysis of the reaction: all-trans-retinoic acid + 2 H+ + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinoic acid + 2 H2O + 2 oxidized [adrenodoxin]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2172433", "l": "Collagen type XIX degradation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9676254", "l": "Formation of the MLL3 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29970", "l": "2'-deoxyuridine(in) + H(+)(in) <=> 2'-deoxyuridine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31420", "l": "(2Z,6E)-farnesyl diphosphate => (-)-beta-curcumene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030701", "l": "NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity", "d": ["Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36217", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210271", "l": "Interaction of DAP12 and MDL-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047961", "l": "glycine N-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53715", "l": "2 Fe(III)-heme b <=> beta-hematin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216043", "l": "Collagen type II binds integrin alpha10beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.850581069382244", "identifiers": [{"i": "GO:0003678", "l": "DNA helicase activity", "d": ["Unwinding of a DNA helix, driven by ATP hydrolysis."]}, {"i": "REACT:R-HSA-5693589", "l": "D-loop dissociation and strand annealing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3209165", "l": "ID1 sequesters ETS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46369", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265456", "l": "NPC1L1 binds ezetimibe (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61623", "l": "[(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose <=> [(1->2)-beta-D-mannosyl](n+1) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317314", "l": "AKT binds PDPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102377", "l": "steviol 13-O glucosyltransferase activity", "d": ["Catalysis of the reaction: steviol + UDP-alpha-D-glucose = steviolmonoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202726", "l": "F11R dimerises (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-481044", "l": "Surface deployment of platelet alpha granule membrane components (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392064", "l": "G alpha (z) inhibits adenylate cyclase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42354", "l": "(R)-6-hydroxynicotine + AH2 => (R)-nicotine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36574", "l": "sphinganine + tetradecanoyl-CoA <=> CoA + H(+) + N-(tetradecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030293", "l": "transmembrane receptor protein tyrosine kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788611", "l": "HYKK phosphorylates 5HLYS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11447", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O <=> 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1362416", "l": "Frataxin binds iron (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52842", "l": "1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP => UDP-alpha-D-glucose + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.2", "l": "\"glucokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23091", "l": "ATP + O-alkylglycerone <=> 1-O-alkylglycerone 3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66909", "l": "acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine => 9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60620", "l": "N-hexanoyl-sphing-4-enine-1-phosphocholine = choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13223", "l": "H(+) + mevaldate + NADH => (R)-mevalonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532667", "l": "Removal of the second glucose by glucosidase II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11737", "l": "2-exo-hydroxy-1,8-cineole + NAD(+) => 6-oxocineole + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44922", "l": "(3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+) => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420117", "l": "VEGFR2 autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202726", "l": "F11R dimerises (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44814", "l": "2-demethylmenaquinol-11 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60672", "l": "NAD(+) + nerol = H(+) + NADH + neral", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390641", "l": "ADRA1A,B,D bind ADR,NAd (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32504", "l": "linalool + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14268", "l": "(S)-4-amino-5-oxopentanoate <=> 5-aminolevulinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9718379", "l": "GNRHR binds chemical antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65794", "l": "3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008215", "l": "RUNX2 binds GLI3R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018804", "l": "RAC3 GEFs activate RAC3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49461", "l": "(2Z,4E)-2-aminomuconate + H2O => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70692", "l": "ornithine => putrescine + CO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35835", "l": "2'-dehydrokanamycin A + H(+) + NADPH = kanamycin A + NADP(+)", "d": []}, {"i": "EC:1.1.1.355", "l": "\"2'-dehydrokanamycin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170986", "l": "Ral-GDS binds to Ras-GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18983", "l": "2-dehydropantolactone + H(+) + NADPH => (R)-pantolactone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46513", "l": "an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.206", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858270", "l": "HILPDA binds lipid droplets (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664879", "l": "ATM:PEX5 binds ATM (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43044", "l": "hexadecasphinganine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018768", "l": "RHOU auto-activates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18489", "l": "cyanate + H(+) + hydrogencarbonate = carbamate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173740", "l": "Factor B binds to C3(H2O) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46176", "l": "2-methylpropanoate + ATP + CoA = 2-methylpropanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33691", "l": "2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635845", "l": "GLI proteins bind CDC73 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44076", "l": "ATP + CoA + pentadecanoate = AMP + diphosphate + pentadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32020", "l": "(2E,6E)-farnesyl diphosphate => beta-cubebene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31509", "l": "H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.43", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046481", "l": "digalactosyldiacylglycerol synthase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + UDP-D-galactose = 3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-diacyl-sn-glycerol + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130706", "l": "MHC class II antigen processing (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691131", "l": "CANDI binds CUL1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70864", "l": "L-glutamine(out) + L-threonine(in) + Na(+)(out) => L-glutamine(in) + L-threonine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11748", "l": "fluoroacetaldehyde + L-threonine = 4-fluoro-L-threonine + acetaldehyde", "d": []}, {"i": "EC:2.2.1.8", "l": "\"fluorothreonine transaldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637798", "l": "Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022851", "l": "GABA-gated chloride ion channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730840", "l": "Activation of RAC1 by VAV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35697", "l": "(2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH => (3S)-versiconol acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35394", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA <=> (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381707", "l": "PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167683", "l": "TrkA phosphorylates PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30016", "l": "alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23519", "l": "(R)-glycerate + ATP <=> (2R)-3-phosphoglycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033419", "l": "CUA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CUA codon."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050105", "l": "L-gulonolactone oxidase activity", "d": ["Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12996", "l": "cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450474", "l": "MK2 phosphorylates BRF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036308", "l": "ESTG-stimulated dissociation of GPER:heterotrimeric G-protein (s) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21514", "l": "2-dehydro-3-deoxy-L-galactonate => 3,6-anhydro-L-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18806", "l": "[DsbA protein]-disulfide + [protein]-dithiol => [DsbA protein]-dithiol + [protein]-disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800380", "l": "PTPRD binds IL1RAP-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14014", "l": "3'-phosphoadenylyl sulfate + taurolithocholate => adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20595", "l": "acetate + D-glucosamine => H2O + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30198", "l": "15,9'-di-cis-phytofluene + plastoquinone-9 <=> 9,9',15-tri-cis-zeta-carotene + plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028583", "l": "Phosphorylation of YAP by LATS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002440", "l": "Removal of fibrillar collagen C-propeptides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35929", "l": "3''-deamino-3''-hydroxykanamycin C + H(+) + UDP => paromamine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68113", "l": "H2O + propanamide => NH4(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74258", "l": "XDH oxidizes xanthine to form urate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9612509", "l": "SGK phosphorylates SRF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10492", "l": "H2O + phosphocholine = choline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44319", "l": "1-dodecanoylglycerol + H2O <=> dodecanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381091", "l": "IRE1 dimer autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66367", "l": "(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O <=> 6-methyl-3,7-dioxodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5333051", "l": "RPA1 binds HSF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32731", "l": "a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848339", "l": "PNPLA5 hydrolyzes TAG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420052", "l": "Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004136", "l": "deoxyadenosine kinase activity", "d": ["Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2752115", "l": "SPP1 (osteopontin) binds CD44 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38629", "l": "1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004668", "l": "protein-arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4+, resulting in citrullination of the target protein. This reaction is calcium-dependent."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038946", "l": "Dimerization of FGFR4 mutants with enhanced kinase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36881", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617941", "l": "Expression of superoxide dismutase 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111970", "l": "PKC phosphorylates GRK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64643", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose <=> lactose + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72808", "l": "L-histidine(out) => L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56271", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174124", "l": "Dephosphorylation of phospho-Cdh1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34039", "l": "2-oxoglutarate + neamine = 6'-oxoparomamine + L-glutamate", "d": []}, {"i": "EC:2.6.1.93", "l": "\"neamine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54129", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0047264", "l": "heteroglycan alpha-mannosyltransferase activity", "d": ["Catalysis of the reaction: heteroglycan + GDP-mannose = alpha-D-mannosylheteroglycan + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42416", "l": "a ubiquinone + L-proline = (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30010", "l": "ATP + H2O + L-arabinose(out) <=> ADP + H(+) + L-arabinose(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050616", "l": "secologanin synthase activity", "d": ["Catalysis of the reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75346", "l": "adenosine(in) <=> adenosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57794", "l": "4-methyl-6-nitrocatechol + NAD(+) + nitrite => 3,4-dinitrotoluene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30803", "l": "4-aminobutanal + H2O + NADP(+) = 4-aminobutanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1067659", "l": "Assembly of hexameric IL-6 receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63092", "l": "H(+) + ilicicolin A + NADPH + O2 = H2O + ilicicolin A epoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66414", "l": "ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out) => ATP + glutathione(in) + H2O + taurochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46693", "l": "4-hydroxybenzoate + ATP + H(+) => 4-hydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72393", "l": "2 hydrogencarbonate(in) + oxalate(out) => 2 hydrogencarbonate(out) + oxalate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5683593", "l": "ATG7:ATG3:LC3 dissociates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58051", "l": "2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA <=> 2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.97", "l": "\"1,3-beta-D-glucan phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851298", "l": "GPR143 binds L-Dopa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879910", "l": "JAK2 is phosphorylated, activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15942", "l": "H2O + N(2)-acetyl-L-ornithine => acetate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64755", "l": "3-sulfanylpentan-1-ol-L-cysteine + H2O <=> 3-sulfanyl-1-pentanol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690196", "l": "USP8 deubiquitinates RNF128 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008889", "l": "glycerophosphodiester phosphodiesterase activity", "d": ["Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800793", "l": "PIDD1 translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730886", "l": "Phosphorylation of SHC by SYK kinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24680", "l": "5,10-methylenetetrahydromethanopterin + H2O => 5,6,7,8-tetrahydromethanopterin + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56245", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70588", "l": "H2O + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) => acetate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0099104", "l": "potassium channel activator activity", "d": ["Binds to and increases the activity of a potassium channel, resulting in its opening."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18549", "l": "[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.11", "l": "\"glycogen(starch) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450088", "l": "GLUT1 tetramer binds 4xATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700156", "l": "Active ALK dimer binds IRS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28166", "l": "5-nitroanthranilate + H(+) + H2O = 5-nitrosalicylate + NH4(+)", "d": []}, {"i": "EC:3.5.99.8", "l": "\"5-nitroanthranilic acid aminohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69029", "l": "5beta-dihydrotestosterone + H(+) + NADPH => 5beta-androstane-3alpha,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016993", "l": "precorrin-8X methylmutase activity", "d": ["Catalysis of the reaction: precorrin-8X = hydrogenobyrinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75614", "l": "H2O + plasmodiophorol A <=> plasmodiophorol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14727", "l": "2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate => 2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53100", "l": "2-hydroxyestrone + S-adenosyl-L-methionine = 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080076", "l": "caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a caffeoyl CoA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187506", "l": "Translocation of p27 to the nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21969", "l": "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate => 3-dehydroquinate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42418", "l": "(S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+) => a ubiquinone + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18710", "l": "A + H2O + taurine => AH2 + NH4(+) + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70481", "l": "TPI1 isomerizes GA3P to DHAP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2172678", "l": "PHF8 demethylates histone H4K20me1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14839", "l": "H(+) + H2O2 + oxalate => glyoxylate + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43872", "l": "3-oxochol-4-en-22-oate + ATP + CoA = 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49503", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203553", "l": "eNOS binds NOSIP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39940", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862300", "l": "LYZ binds bacterial peptidoglycan (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31188", "l": "(3S)-hydroxydecanoyl-CoA + NAD(+) => 3-oxodecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29681", "l": "formate(out) => formate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23447", "l": "(S)-lactate + NAD(+) <=> H(+) + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186765", "l": "PLC-gamma binds to the active receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976801", "l": "Complement factor I complex formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75715", "l": "CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + pantetheine 4'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38114", "l": "glycerol + NADP(+) <=> H(+) + L-glyceraldehyde + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371518", "l": "SIRT1 binds to HSF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725030", "l": "MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696183", "l": "AOC3 deaminates BZAM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45391", "l": "H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016483", "l": "tryptophan hydroxylase activator activity", "d": ["Increases the activity of the enzyme tryptophase hydroxylase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814695", "l": "PERP binds desmosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243937", "l": "PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008854", "l": "exodeoxyribonuclease V activity", "d": ["Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64050", "l": "CoA + H(+) + N-(13Z-docosenoyl)-sphinganine => (13Z)-docosenoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16930", "l": "2 benzoyl-CoA + L-ornithine => 2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66718", "l": "(2S)-3-sulfolactaldehyde + D-fructose 6-phosphate => 6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48261", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 => CMP + ganglioside GD1a + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23902", "l": "(1R,2R)-hydrobenzoin => cis-stilbene oxide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44226", "l": "16-hydroxyhexadecanoyl-CoA + AMP + diphosphate => 16-hydroxyhexadecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62427", "l": "(E)-caffeoyl-CoA + H2O <=> 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17859", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate => O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17752", "l": "A + H2O + quinoline <=> AH2 + quinolin-2(1H)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174070", "l": "Association of Cdh1 with the APC/C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53376", "l": "5,6-dihydrouridine(16) in tRNA + NADP(+) = H(+) + NADPH + uridine(16) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52472", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44796", "l": "2-demethylmenaquinol-13 + S-adenosyl-L-methionine = H(+) + menaquinol-13 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27692", "l": "ADP + dGTP => ATP + dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45322", "l": "H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine => H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35899", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173740", "l": "Factor B binds to C3(H2O) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917730", "l": "Cargo Recognition And Sorting (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18613", "l": "4-methoxybenzoate + AH2 + O2 = 4-hydroxybenzoate + A + formaldehyde + H2O", "d": []}, {"i": "EC:1.14.99.15", "l": "\"4-methoxybenzoate monooxygenase (O-demethylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111956", "l": "Calmodulin activates Cam-PDE 1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64098", "l": "2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP] => 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41741", "l": "adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2106625", "l": "Duplex siRNA is loaded into Argonaute (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694661", "l": "TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-571318", "l": "Autoubiquitination of oligoTRAF6 bound to p-IRAK2  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10317", "l": "2-oxoglutarate + O2 + thymine => 5-hydroxymethyluracil + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57176", "l": "L-arginyl-[protein] + methylglyoxal = N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66722", "l": "ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate => ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42826", "l": "H2O + 2 NAD(+) + tetracenomycin C => 2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40415", "l": "H2O + pristanoyl-CoA = 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59181", "l": "5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O => 2 AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.35", "l": "\"sn-2 acyl-lipid omega-3 desaturase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156678", "l": "Activation of Cdc25C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68061", "l": "a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase] => a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30251", "l": "2 a ubiquinol + n H(+)(in) + O2 = 2 a ubiquinone + n H(+)(out) + 2 H2O", "d": []}, {"i": "EC:7.1.1.3", "l": "\"ubiquinol oxidase (H(+)-transporting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2423785", "l": "CR:atREs binds apoE and HSPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853793", "l": "p-5Y-RET complexes bind GRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10529", "l": "dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0003720", "l": "telomerase activity", "d": ["Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44421", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433711", "l": "Cis-homodimerization of nectins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69068", "l": "RFC dissociates after sliding clamp formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203553", "l": "eNOS binds NOSIP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.3", "l": "\"dephospho-[reductase kinase] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60238", "l": "2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58577", "l": "dihydroprecondylocarpine acetate + NADP(+) => H(+) + NADPH + precondylocarpine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426223", "l": "Cation influx mediated by TRPC3/6/7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061710", "l": "L-threonylcarbamoyladenylate synthase", "d": ["Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15435", "l": "diphosphate + sophoraflavanone B => (2S)-naringenin + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65203", "l": "S-(acetaldehyde)-L-cysteine <=> (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227755", "l": "Recruitment of IKK complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093327", "l": "EPHA binds TIAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213195", "l": "Formation of anchoring fibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254251", "l": "ERBB4s80 binds YAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418200", "l": "SRC-1 bound to ARRB2 is not activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41664", "l": "dihydrochelirubine + NAD(+) = chelirubine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52523", "l": "O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0017077", "l": "oxidative phosphorylation uncoupler activity", "d": ["Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64369", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10258", "l": "[(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate => [(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61271", "l": "H2O + L-2-aminohexanoate + O2 <=> 2-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.24", "l": "\"candidapepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16390", "l": "4-hydroxybenzoate + 2 H(+) + NADH + O2 => CO2 + H2O + hydroquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-179410", "l": "Association of Nek2A with MCC:APC/C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1011598", "l": "DOCKs bind to RhoGEFs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8857686", "l": "FITM1, FITM2 bind TAGs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375302", "l": "Kinetochore capture of astral microtubules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030298", "l": "receptor signaling protein tyrosine kinase activator activity", "d": ["Binds to and increases the activity of a receptor signaling protein tyrosine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.148", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56718", "l": "H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate => H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5246478", "l": "APOM binds retinoids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0046030", "l": "inositol trisphosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44040", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = 14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070403", "l": "NAD+ binding", "d": ["Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36154", "l": "(E)-cinnamyl alcohol + acetyl-CoA <=> (E)-cinnamyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000310", "l": "AURKA phosphorylates PLK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004966", "l": "galanin receptor activity", "d": ["Combining with galanin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14878", "l": "ATP + L-glutamate => ADP + L-glutamyl 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66887", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18279", "l": "a methyl thioether + H(+) + S-adenosyl-L-homocysteine => a thiol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29690", "l": "alpha-maltoheptaose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltohexaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16125", "l": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47374", "l": "a quinol + D-glucono-1,5-lactone => a quinone + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928624", "l": "EPHBs bind EFNBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27472", "l": "H2O + N,N'-diacetylchitobiose <=> acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46727", "l": "(2S)-2-methyltetradecanoyl-CoA <=> (2R)-2-methyltetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665998", "l": "MKL1 binds SRF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43568", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) = 3,6-anhydro-L-galactonate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61805", "l": "ATP + H(+) + L-alanine => diphosphate + L-alanyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35271", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444047", "l": "Receptor FFAR3 binds carboxylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72896", "l": "2 acetyl-CoA + 3 H(+) + 6 malonyl-CoA + 2 S-adenosyl-L-methionine => 4-O-demethylbarbatate + 6 CO2 + 8 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158399", "l": "kallikrein binds SERPING1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430183", "l": "NCK binds PAK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160915", "l": "Receptor-mediated uptake of HA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018808", "l": "RAC3 binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64704", "l": "diphenylmethanol + NAD(+) = benzophenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21673", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196929", "l": "FLAD1 phosphorylates FMN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193653", "l": "NGF homodimer binds to p75NTR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32188", "l": "cholest-5-en-3-one => cholest-4-en-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016760", "l": "cellulose synthase (UDP-forming) activity", "d": ["Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429529", "l": "Thrombin binding to GP1b:IX:V (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32770", "l": "cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39742", "l": "3-hydroxydodecanoate + H(+) + NADPH + O2 <=> 3,12-dihydroxydodecanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30852", "l": "beta-D-fructose 1-phosphate => D-glyceraldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381727", "l": "RAP1A exchanges GDP for GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47305", "l": "(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033867", "l": "Fas-activated serine/threonine kinase activity", "d": ["Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004417", "l": "hydroxyethylthiazole kinase activity", "d": ["Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061810", "l": "NAD glycohydrolase activity", "d": ["Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose without proceeding through a cyclic ADP-ribose intermediate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140773", "l": "NAD-dependent protein demyristoylase activity", "d": ["Catalysis of the reaction: N6-tetradecanoyl-L-lysyl-[protein] + NAD+ + H2O = tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:70567", "l": "H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944254", "l": "Association of procollagen type XXVI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75856", "l": "Abortive Initiation Before Second Transition (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36627", "l": "2-hydroxytetracosanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54637", "l": "(13E)-labda-7,13-dien-15-yl diphosphate => diphosphate + labda-7,13(16),14-triene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74430", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32525", "l": "beta-D-glucose 1-phosphate + D-glucose => nigerose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25094", "l": "ATP + dCMP = ADP + dCDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14964", "l": "H2O + S-formylglutathione <=> formate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40748", "l": "2-oxoglutarate + L-lysine + O2 => (3S)-3-hydroxy-L-lysine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983153", "l": "E1 mediated ubiquitin activation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.43", "l": "\"cathepsin V\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16171", "l": "ADP + H(+) + L-glutamine + phosphate => ATP + L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19290", "l": "H2O + sucrose 6(F)-phosphate => phosphate + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52743", "l": "glyphosate + H2O + O2 <=> aminomethylphosphonate + glyoxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13480", "l": "H2O + L-tryptophan + NADP(+) <=> H(+) + indole-3-pyruvate + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.129", "l": "\"acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65447", "l": "butanoyl-CoA + hexan-1-ol <=> CoA + hexyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66474", "l": "18-episcalar-17(25)-en-19-ol => (2Z,6E,10E,14E)-geranylfarnesol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69127", "l": "Formation of the Flap Intermediate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47593", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) => CMP + ganglioside GP1c (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59615", "l": "beta-alanyl-L-ornithine + H2O <=> beta-alanine + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.30", "l": "\"pycnoporopepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16571", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[collagen] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58975", "l": "H2O + O2 + vanillin <=> H(+) + H2O2 + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202472", "l": "Translocation of TRAF6 to CBM complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67191", "l": "ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out) <=> ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41441", "l": "(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 => (1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36419", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12651", "l": "H(+) + L-rhamnono-1,4-lactone + NADH => L-rhamnofuranose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0016504", "l": "peptidase activator activity", "d": ["Binds to and increases the activity of a peptidase."]}, {"i": "REACT:R-HSA-168865", "l": "NA activation of TGF-beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35436", "l": "cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose => cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33844", "l": "H2O + N-tetracosanoylsphinganine => sphinganine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38872", "l": "uridine(2457) in 23S rRNA => pseudouridine(2457) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69173", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] => (2E)-2-butenoate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.66", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33541", "l": "a carboxylate + ergosterol + H(+) => ergosteryl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18719", "l": "3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine => 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53515", "l": "(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O <=> (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18722", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate => diphosphate + ent-13-epi-manoyl oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651789", "l": "LIG1 bound to POLB ligates SSB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913451", "l": "IL3RB is phosphorylated on Ser-585 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74497", "l": "yaequinolone C => [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64427", "l": "H(+)(out) + L-leucyl-L-proline(out) <=> H(+)(in) + L-leucyl-L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851011", "l": "TRIM27 polyubiquitinates PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874685", "l": "CBL binds MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44866", "l": "a 1,2-diacylglycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69033", "l": "N,N-dihydroxy-L-aspartate => (2S)-2-nitrosobutanedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853793", "l": "p-5Y-RET complexes bind GRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3266557", "l": "Factor I cleaves iC3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69714", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphinganine + H2O <=> beta-D-glucose + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6813740", "l": "GDE1 hydrolyzes GroPIns (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375140", "l": "CDO binds promyogenic cadherins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047288", "l": "beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase", "d": ["Catalysis of the reaction: beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938150", "l": "RUNX1:CBFB binds the PRKCQ gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73115", "l": "quercetin + S-adenosyl-L-methionine = H(+) + rhamnetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12024", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + choline = D-glucose + O-sinapoylcholine", "d": []}, {"i": "EC:2.3.1.91", "l": "\"sinapoylglucose--choline O-sinapoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57478", "l": "2-hydroxydodecanoate + H2O => dodecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194818", "l": "botA LC cleaves target cell SNAP25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75372", "l": "guanosine(in) => guanosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63041", "l": "H2O + lovastatin => H(+) + lovastatin carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42671", "l": "L-rhamnofuranose + NADP(+) <=> H(+) + L-rhamnono-1,4-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102123", "l": "gibberellin A4 16alpha,17 epoxidase activity", "d": ["Catalysis of the reaction: gibberellin A4 + O2 + H+ + NAD(P)H <=> 16alpha,17-epoxy gibberellin A4 + H2O + NAD(P)."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0090492", "l": "N,N-Dihydroxy-L-tryptophan decarboxylase activity", "d": ["Catalyzes the reaction: N,N-Dihydroxy-L-tryptophan = Indole-3-acetaldehyde oxime + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617413", "l": "Expression of GLI2 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37565", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50871", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 <=> (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32106", "l": "2 S-adenosyl-L-methionine + trans-resveratrol <=> 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350186", "l": "CUBN binds GC:25(OH)D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002952", "l": "(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity", "d": ["Catalysis of the reaction (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione = 3-hydroxy-5-phosphonooxypentane-2,4-dione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11688", "l": "ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)", "d": []}, {"i": "EC:6.1.1.4", "l": "\"leucine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0005123", "l": "death receptor binding", "d": ["Binding to a member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12698", "l": "ATP + dGMP => ADP + dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086076", "l": "gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from an atrial cardiomyocyte to an AV node cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1297354", "l": "Acrosin Cleavage (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60679", "l": "(S)-(-)-citronellol + NAD(+) <=> (S)-(-)-citronellal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20311", "l": "2 H2O + O2 => 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685603", "l": "SAP and EAT2 binds SLAMF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72017", "l": "2 A + 6 CO2 + 7 CoA + 6 H2O + 5 NADP(+) + 2 S-adenosyl-L-homocysteine + trihazone A => acetyl-CoA + 2 AH2 + 9 H(+) + malate + 6 malonyl-CoA + 5 NADPH + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174255", "l": "Degradation multiubiquitinated Cyclin A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46880", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981728", "l": "Factor H binds to membrane-associated C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139899", "l": "Sequestration of BAD protein by 14-3-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62079", "l": "D-galactose 6-phosphate + NAD(+) <=> 6-phospho-D-galactono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68607", "l": "(2S)-3-sulfopropanediol <=> H(+) + hydroxyacetone + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46466", "l": "(24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036140", "l": "[protein]-asparagine 3-dioxygenase activity", "d": ["Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696323", "l": "CNRs bind CNR agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51895", "l": "H2O + N-acetylcadaverine <=> acetate + cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2995330", "l": "COX10 transforms heme to heme O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19377", "l": "NADP(+) + reduced riboflavin = 2 H(+) + NADPH + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60400", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49793", "l": "eicosanoyl-CoA + glycine => CoA + H(+) + N-eicosanoylglycinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50081", "l": "ATP + H2O + taurodeoxycholate(in) => ADP + H(+) + phosphate + taurodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.22", "l": "\"vitamin D 1,25-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45223", "l": "coenzyme M + methyl-Co(III)-[trimethylamine-specific corrinoid protein] <=> Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23477", "l": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24507", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 <=> 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170986", "l": "Ral-GDS binds to Ras-GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27842", "l": "9H-carbazole + H(+) + NADPH + O2 = 2'-aminobiphenyl-2,3-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015591", "l": "D-ribose transmembrane transporter activity", "d": ["Enables the transfer of D-ribose from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088306", "l": "FOXM1 binds PLK1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20184", "l": "alpha-D-mannose derivative + UDP-alpha-D-glucose <=> 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749253", "l": "Formation of MCM2-7 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793382", "l": "TBX6 and LEF1:CTNNB1 bind the MSGN1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54348", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015132", "l": "prostaglandin transmembrane transporter activity", "d": ["Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64233", "l": "8 H(+) + holo-[ACP] + 8 malonyl-CoA => atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51151", "l": "a primary alcohol + 2 oxidized [azurin] <=> an aldehyde + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52287", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004632", "l": "phosphopantothenate--cysteine ligase activity", "d": ["Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12891", "l": "3-dehydro-L-gulonate + H(+) + NADH => L-gulonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23681", "l": "a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70045", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + teasterone => 6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49225", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] => dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63130", "l": "docosanoate + ethanolamine => H2O + N-docosanoyl-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687107", "l": "MAPK4,6 translocate to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9634861", "l": "NPAS4 binds ARNT2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004531", "l": "deoxyribonuclease II activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169398", "l": "ISGylation of host protein filamin B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42494", "l": "3'-N-debenzoyltaxol + A + H2O => 3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13102", "l": "4-imidazolone-5-propanoate => H2O + trans-urocanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14478", "l": "a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14782", "l": "ATP + CoA + heptanedioate => 6-carboxyhexanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76466", "l": "CYP4A11 12-hydroxylates DDCX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23883", "l": "L-histidyl-[protein] + phosphoenolpyruvate <=> N(pros)-phospho-L-histidyl-[protein] + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49143", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102826", "l": "kaempferol-3-glucoside-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + kaempferol 3-O-glucoside <=> kaempferol 3,7-O-diglucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23035", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381435", "l": "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69499", "l": "decan-1-ol + O2 <=> decanal + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49294", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein] => D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37534", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183052", "l": "CBL binds to GRB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29135", "l": "a menaquinol + 2 H(+)(in) + nitrate = a menaquinone + 2 H(+)(out) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38387", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56193", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201630", "l": "Caspase-mediated cleavage of Acinus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36592", "l": "(S)-2-chloropropanoate + NADP(+) => 2-chloroacrylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23408", "l": "NADP(+) + precorrin-6B = 2 H(+) + NADPH + precorrin-6A", "d": []}, {"i": "EC:1.3.1.54", "l": "\"precorrin-6A reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52585", "l": "chenodeoxycholoyl-CoA + NAD(+) => 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15520", "l": "H2O + N(2),6-disulfo-D-glucosamine <=> H(+) + N-sulfo-D-glucosamine + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749590", "l": "ASA- acetylates ALB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56170", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75515", "l": "H2O + N-acetyl-L-cysteine = acetate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77589", "l": "Recognition of AAUAAA sequence by CPSF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47686", "l": "[(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->2)-beta-D-glucosyl](n) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39686", "l": "3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH <=> (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18932", "l": "AH2 + O2 + thiophene-2-carbonyl-CoA <=> 5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40753", "l": "1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate => (9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990381", "l": "ubiquitin-specific protease binding", "d": ["Binding to a ubiquitin-specific protease."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534240", "l": "HSPG2 (perlecan) degradation by MMP14, MMP15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.11", "l": "\"3-oxo-Delta(1)-steroid hydratase/dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58285", "l": "5,6-dihydrothymine + NADP(+) => H(+) + NADPH + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821941", "l": "BOD1 binds SET1B complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23668", "l": "apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin = AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]", "d": []}, {"i": "EC:6.3.4.9", "l": "\"biotin--[methylmalonyl-CoA-carboxytransferase] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15149", "l": "O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74753", "l": "holo-[polyketide synthase] + prefumagillin => dodecapentaneoyl-[polyketide synthase] + fumagillol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60870", "l": "a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11242", "l": "ADP + thiamine triphosphate => ATP + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.54", "l": "\"lytic cellulose monooxygenase (C1-hydroxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606602", "l": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509831", "l": "ITPA hydrolyses XTP to XMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9619376", "l": "CAMK1 binds calmodulin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44612", "l": "3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52659", "l": "a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) <=> a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18557", "l": "1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA = 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA", "d": []}, {"i": "EC:2.3.1.105", "l": "\"alkylglycerophosphate 2-O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2514865", "l": "cGMP dissociates from CNG channels (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70594", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66223", "l": "asc-omegaC7-CoA + O2 <=> asc-omegaDeltaC7-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204871", "l": "Interaction of Tie2 and Grb2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9663511", "l": "BIL binds GSTA1, FABP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65700", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] = cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65236", "l": "3-methylbutanol + acetyl-CoA = 3-methylbutyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944236", "l": "Association of procollagen type XIV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211959", "l": "CYP3A43 6b-hydroxylates TEST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17411", "l": "(S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine => (S)-coclaurine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0003684", "l": "damaged DNA binding", "d": ["Binding to damaged DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357432", "l": "AXL binds SRC-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73450", "l": "acetyl-CoA(in) + AMP(out) <=> acetyl-CoA(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22751", "l": "4-hydroxy-4-methyl-2-oxoglutarate <=> 2 pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33223", "l": "2-oxobutanoate + CoA + NAD(+) = CO2 + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102942", "l": "3,5-dimethoxyphenol O-methyltransferase activity", "d": ["Catalysis of the reaction: 3,5-dimethoxyphenol + S-adenosyl-L-methionine = H+ + 1,3,5-trimethoxybenzene + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55119", "l": "5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34880", "l": "2 H2O + methyl 3-cyano-2-phenylpropanoate => 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.3.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56780", "l": "(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050010", "l": "isovitexin beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: isovitexin + UDP-D-glucose = H+ + isovitexin 2''-O-beta-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13708", "l": "alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine <=> alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15581", "l": "biochanin A 7-O-beta-D-glucoside + malonyl-CoA = biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA", "d": []}, {"i": "EC:2.3.1.115", "l": "\"isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015247", "l": "aminophospholipid flippase activity", "d": ["Enables the transfer of aminophospholipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11302", "l": "2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH => 1D-5-O-methyl-myo-inositol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15106", "l": "kaempferol + S-adenosyl-L-methionine => H(+) + kaempferide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38837", "l": "1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64424", "l": "H(+)(out) + L-leucyl-L-proline(out) = H(+)(in) + L-leucyl-L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62302", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+) => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689649", "l": "BAP1 binds BRCA1:BARD1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20284", "l": "(Z)-desulfoglucotropeolin + 3'-phosphoadenylyl sulfate <=> (Z)-glucotropeolin + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24773", "l": "7(1)-hydroxychlorophyllide a + NADP(+) => chlorophyllide b + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40402", "l": "1,2-dihydro-beta-NADP + H(+) + O2 <=> H2O2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875371", "l": "InlB binds MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35503", "l": "11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23100", "l": "ATP + dAMP = ADP + dADP", "d": []}, {"i": "EC:2.7.4.11", "l": "\"(deoxy)adenylate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40172", "l": "dodecanoyl-CoA + O2 => (2E)-dodecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64749", "l": "H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine => 2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336443", "l": "LIN7, CASK and APBA1 bind (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37781", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682011", "l": "LC3 binds ATG7 dimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944219", "l": "Association of procollagen type XVI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296127", "l": "Activation of voltage gated Potassium channels (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61846", "l": "H(+) + solasodine 3-beta-D-glucoside + UDP => solasodine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51302", "l": "H2O + N-(9Z-octadecenoyl)-L-phenylalanine => (9Z)-octadecenoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941895", "l": "Formation of CDK4/6:CCND complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52245", "l": "4 H(+) + 4 Mn(2+) + O2 => 2 H2O + 4 Mn(3+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614591", "l": "Excess cysteine yields lanthionine and H2S (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2990882", "l": "CDK1 phosphorylates NUP98 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109701", "l": "PDPK1 binds PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.6", "l": "\"chalcone isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62415", "l": "(E)-feruloyl-CoA + H2O <=> acetyl-CoA + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15596", "l": "amicoumacin A 2-phosphate + H2O <=> amicoumacin A + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693598", "l": "ATM phosphorylates NBN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-912727", "l": "CBL binds VAV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51677", "l": "[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide => [protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052900", "l": "spermine oxidase (propane-1,3-diamine-forming) activity", "d": ["Catalysis of the reaction: H2O + O2 + spermine = 1,3-diaminopropane + H2O2 + N-(3-aminopropyl)-4-aminobutanal."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018663", "l": "2,6-dihydroxypyridine 3-monooxygenase activity", "d": ["Catalysis of the reaction: 2,6-dihydroxypyridine + H+ + NADH + O2 = 2,3,6-trihydroxypyridine + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23988", "l": "(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate", "d": []}, {"i": "EC:2.6.1.83", "l": "\"LL-diaminopimelate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14725", "l": "2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.49", "l": "\"O-acetylhomoserine aminocarboxypropyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-209792", "l": "N-acetylation of serotonin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74712", "l": "Dissociation of IRS-P from insulin receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381612", "l": "GLP1R binds GLP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60438", "l": "3-methylbutanol + acetate + H(+) => 3-methylbutyl acetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47674", "l": "2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30549", "l": "(2E)-hexenoyl-CoA + H2O => (3S)-hydroxyhexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11799", "l": "ecdysone + O2 <=> 3-dehydroecdysone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-912627", "l": "CBL ubiquitinates PI3K (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32083", "l": "CTP + pseudaminate = CMP-pseudaminate + diphosphate", "d": []}, {"i": "EC:2.7.7.81", "l": "\"pseudaminic acid cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473594", "l": "Collagen type II degradation by MMP15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56970", "l": "dCDP + H(+) + phosphoenolpyruvate => dCTP + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684340", "l": "3CLp cleaves pp1ab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019770", "l": "IgG receptor activity", "d": ["Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351948", "l": "Mitochondrial recruitment of Drp1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17723", "l": "a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44666", "l": "a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634934", "l": "CDK5R1 gene expression is stimulated by NPAS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29357", "l": "2'-deoxyuridine + phosphate => dUMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75679", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61224", "l": "H2O + L-asparagine + O2 = 2-oxosuccinamate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19349", "l": "(R)-4-dehydropantoate + H2O + NAD(+) = (R)-3,3-dimethylmalate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.33", "l": "\"(R)-dehydropantoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4647593", "l": "EP400 binds CDKN1A promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66601", "l": "2 dopamine + O2 => 2 dopamine quinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19319", "l": "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61356", "l": "ATP + H2O + methotrexate(in) = ADP + H(+) + methotrexate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693243", "l": "RHOD translocates to the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14227", "l": "6-oxohexanoate + H(+) + NADH => 6-hydroxyhexanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14962", "l": "H2O + S-formylglutathione => formate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2981040", "l": "COLEC12:ligand is endocytosed (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75111", "l": "32-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29326", "l": "fumarate(in) + succinate(out) <=> fumarate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38950", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12751", "l": "1,2,3-trihydroxybenzene + CO2 => 3,4,5-trihydroxybenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25521", "l": "an acyl-CoA + pseudotropine => CoA + H(+) + O-acylpseudotropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64034", "l": "a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865182", "l": "OTUD7A hydrolyses K11diUb (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22925", "l": "dCMP + H(+) + H2O => dUMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73932", "l": "Resynthesis of excised residue by POLB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806419", "l": "TP53 binds the FANCC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10276", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4608855", "l": "PRICKLE1 is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32904", "l": "calciol + O2 + reduced [NADPH--hemoprotein reductase] => calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611851", "l": "ADRB2 bind ADR,NAd (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852010", "l": "BTNL2 binds activated T cells surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65137", "l": "(9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21622", "l": "FMN + 2 H(+) + NADH => FMNH2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606564", "l": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578712", "l": "Importin-8 binds AGO2:miRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15926", "l": "dihydrobunolol + NADP(+) => bunolol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20902", "l": "benzyl alcohol + CO2 + glycine => H(+) + H2O + N-benzyloxycarbonylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047202", "l": "sinapoylglucose-choline O-sinapoyltransferase activity", "d": ["Catalysis of the reaction: 1-O-sinapoyl-beta-D-glucose + choline = O-sinapoylcholine + D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018807", "l": "RAC3 GDIs block activation of RAC3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12898", "l": "2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] => (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54584", "l": "a guanosine in 18S rRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41870", "l": "3-oxododecanoyl-[ACP] + CO2 + holo-[ACP] => decanoyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43995", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 <=> 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.19", "l": "\"D-stereospecific aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62477", "l": "3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29432", "l": "ATP + phosphate => ADP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982765", "l": "Growth hormone forms dimers and oligomers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112514", "l": "JAK activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41084", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.49", "l": "\"1-pyrroline-2-carboxylate reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20423", "l": "D-glucose + D-glucose 6-phosphate => alpha-maltose 6'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389354", "l": "Activation of Vav1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68813", "l": "(2Z,6E)-farnesyl diphosphate => beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41468", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.122", "l": "\"oryzalexin E synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.53", "l": "\"trimerelysin II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0051735", "l": "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: GTP + 5'-dephosphopolynucleotide = GDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37993", "l": "beta-tocopherol + H(+) + S-adenosyl-L-homocysteine => delta-tocopherol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000334", "l": "3-hydroxyanthranilate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxyanthranilate + O2 = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68319", "l": "1D-myo-inositol 2,3,4,5-tetrakisphosphate + H2O <=> 1D-myo-inositol 2,4,5-triphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65306", "l": "chrodrimanin T + CO2 + succinate => 2-oxoglutarate + O2 + verruculide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72767", "l": "acetyl-CoA + 9 H(+) + 4 malonyl-CoA + 5 NADPH = 7-methylmellein + 3 CO2 + 5 CoA + 4 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647746", "l": "EML4 trimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1470010", "l": "Dimerization of STATs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23135", "l": "3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] <=> 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372529", "l": "Release of acetylcholine at the synapse (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31734", "l": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 <=> 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72069", "l": "ADP + gamma-L-glutamyl-(2S)-2-aminobutanoate + H(+) + phosphate => (2S)-2-aminobutanoate + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65477", "l": "1-propanol + butanoyl-CoA => CoA + propyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73354", "l": "ATP + beta-alanine + histamine <=> AMP + carcinine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73136", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine => 4',7-dihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59757", "l": "L-arginine + S-adenosyl-L-methionine => H(+) + N(omega)-methyl-L-arginine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30859", "l": "dITP + H2O = dIDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112042", "l": "Opioid binds MOR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73398", "l": "L-aspartate(in) + sulfate(out) <=> L-aspartate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71798", "l": "(R)-3-hydroxybutanoate(out) + H(+)(out) <=> (R)-3-hydroxybutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964759", "l": "Alternative endo-mannosidase I route (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18211", "l": "(2S,4R)-bornyl diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37360", "l": "D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] => D-glucosamine 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682010", "l": "ATG10:ATG12 binds ATG5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.360", "l": "\"glucose/galactose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848124", "l": "PTK6 phosphorylates STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71783", "l": "MDH2 reduces OA to MAL (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59611", "l": "beta-alanyl-L-lysine + H2O <=> beta-alanine + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40196", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9670014", "l": "Factor VIIIa dissociates  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166542", "l": "beta-NGF dimer binds to TrkA receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102721", "l": "ubiquinol:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: O2 + 2 an ubiquinol = 2 H2O + 2 an ubiquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444191", "l": "GPR120 is a receptor for unsaturated long-chain free fatty acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706308", "l": "Active FLT3 binds to GRB10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56953", "l": "CTP + pyruvate => CDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25420", "l": "3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O = 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate", "d": []}, {"i": "EC:1.3.99.n1", "l": "\"3-hydroxybenzoyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.4.1.6", "l": "\"acetone carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54426", "l": "4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide => L-aspartyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53082", "l": "4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624952", "l": "Assembly of the retrograde IFT train (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45830", "l": "3-oxohexanoyl-CoA + H(+) + NADH => (3R)-hydroxyhexanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19169", "l": "L-serine = NH4(+) + pyruvate", "d": []}, {"i": "EC:4.3.1.17", "l": "\"L-serine ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68595", "l": "ORC2 binds ORC3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41874", "l": "(3R)-hydroxydodecanoyl-[ACP] + NADP(+) => 3-oxododecanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26136", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15333", "l": "(S)-ureidoglycolate + NADP(+) = H(+) + N-carbamoyl-2-oxoglycine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75352", "l": "2 Fe(III)-[cytochrome c] + H2O + pseudooxynicotine => 4-oxo-4-(pyridin-3-yl)butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69013", "l": "5beta-dihydrotestosterone + H(+) + NADPH => 5beta-androstane-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418874", "l": "Recruitment and activation of N-WASP by Cdc42 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852013", "l": "BTNL8 binds resting T cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19415", "l": "AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe) => ATP + L-phenylalanine + tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51303", "l": "(9Z)-octadecenoate + L-phenylalanine <=> H2O + N-(9Z-octadecenoyl)-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167601", "l": "Degradation of CD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30241", "l": "n a quinol + n sulfur => n a quinone + n H(+) + n hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61140", "l": "(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + myricetin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70669", "l": "H(+) + holo-[ACP] + N(6)-(fatty acyl)-L-lysyl-[protein] => a fatty acyl-[ACP] + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24551", "l": "an N(6)-acyl-L-lysine + H2O <=> a carboxylate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209960", "l": "Diiodinated tyrosine can be deiodinated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34884", "l": "ATP + H2O + selenate(out) => ADP + H(+) + phosphate + selenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202472", "l": "Translocation of TRAF6 to CBM complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2219524", "l": "PDPK1 binds PIP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9725855", "l": "NR3C2 binds NR3C2 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26263", "l": "2 H(+) + isopimarate + NADPH => H2O + isopimara-7,15-dienal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9709098", "l": "DHFR dimer reduces FOLA to DHF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210290", "l": "Interaction of PECAM-1 and SHIP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65832", "l": "AH2 + ATP + 2 Co(II)-[dimethylamine-specific corrinoid protein] + H2O = A + ADP + 2 Co(I)-[dimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24698", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700154", "l": "Active ALK binds SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139919", "l": "Translocation of BIM to mitochondria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39943", "l": "a 1-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32640", "l": "(6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879909", "l": "Activation of STAT5a/b by JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749505", "l": "LRRC14 binds IKBKB and CHUK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57946", "l": "CO2 + 2 H2O + heme b => H(+) + H2O2 + harderoheme III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64753", "l": "3-sulfanylpentan-1-ol-L-cysteine + H2O => 3-sulfanyl-1-pentanol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-874087", "l": "SGT1 binds HSP90 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390929", "l": "HTR1 and 5A receptors can bind serotonin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60326", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56947", "l": "AH2 + D-ribulose 5-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48251", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) <=> CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036104", "l": "Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BMG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31051", "l": "(3R)-beta-leucine + H2O + NAD(+) = 4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549467", "l": "Expression of CRYPTOCHROME-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64734", "l": "(11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41163", "l": "1-O-hexadecyl-2-amino-sn-glycerol + ATP = 1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42575", "l": "3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) <=> 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63029", "l": "(15Z)-tetracosenamide + H2O => (15Z)-tetracosenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849908", "l": "SALM4 binds flotillin-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55189", "l": "5-methyluridine(54) in tRNA + ATP + hydrogen sulfide => 5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37917", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57987", "l": "(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rd + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606159", "l": "BTK autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64926", "l": "dAMP + 2 H(+) + 2 phosphate => dATP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13465", "l": "(S)-2,3-diaminopropanoate + oxalyl-CoA = CoA + N(3)-oxalyl-L-2,3-diaminopropanoate", "d": []}, {"i": "EC:2.3.1.58", "l": "\"2,3-diaminopropionate N-oxalyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174444", "l": "Formation of C-strand Okazaki fragments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.196", "l": "\"limit dextrin alpha-1,6-maltotetraose-hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64633", "l": "acetyl-CoA + butan-1-ol => butyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64234", "l": "atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O => 8 H(+) + holo-[ACP] + 8 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140413", "l": "zinc:bicarbonate:selenite symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) + HO3Se-(out) = zinc(in) + HCO3-(in) + HO3Se-(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623643", "l": "RDH13 reduces atRAL to atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448678", "l": "CTSG cleaves CASP1(1-404) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362386", "l": "Glycosylation of Hh (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66707", "l": "H2O + mycophenolyl-CoA <=> CoA + H(+) + mycophenolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43279", "l": "ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GalNAc-GD1a + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70430", "l": "H2O + phenylacetyl-CoA <=> 2-phenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112037", "l": "Inactivation of PLC beta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22855", "l": "L-serine + pyruvate <=> 3-hydroxypyruvate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14689", "l": "4-chlorophenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD(+)", "d": []}, {"i": "EC:1.14.12.9", "l": "\"4-chlorophenylacetate 3,4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22644", "l": "O2 + protopine + reduced [NADPH--hemoprotein reductase] = 6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.98", "l": "\"protopine 6-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61650", "l": "AMP + diphosphate + salicyl-[non-ribosomal peptide synthase] => ATP + holo-[non-ribosomal peptide synthase] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61600", "l": "[DsbD protein]-disulfide + [protein]-dithiol = [DsbB protein]-dithiol + [protein]-disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42756", "l": "cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.178", "l": "\"16S rRNA (cytosine(1407)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13565", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol = 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)", "d": []}, {"i": "EC:2.7.8.12", "l": "\"teichoic acid poly(glycerol phosphate) polymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662606", "l": "MT3 binds zinc (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351894", "l": "Caspase mediated cleavage of BAP31 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28094", "l": "di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.27", "l": "\"undecaprenyl-diphosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36717", "l": "an N-tetracosenoylsphinganine + CoA + H(+) => sphinganine + tetracosenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.43", "l": "\"carboxynorspermidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32712", "l": "a (3R)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50324", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635842", "l": "ULK3 phosphorylates GLI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047840", "l": "dCTP diphosphatase activity", "d": ["Catalysis of the reaction: dCTP + H2O = dCMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176175", "l": "Stalling of DNA replication fork and RPA binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59856", "l": "Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium = methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] + trimethylamine", "d": []}, {"i": "EC:2.1.1.252", "l": "\"tetramethylammonium--corrinoid protein Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62238", "l": "a cytidine dimer in DNA + H(+) => a cytidine(6-4)cytidine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41888", "l": "3-oxotetradecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23810", "l": "(S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine => (S)-scoulerine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44320", "l": "1-decanoylglycerol + H2O = decanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033436", "l": "AUG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AUG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67164", "l": "bromide + FADH2 + melleolide F + O2 = 6'-bromomelleolide F + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69887", "l": "Na(+)(out) + uridine(out) = Na(+)(in) + uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38788", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071837", "l": "HMG box domain binding", "d": ["Binding to an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983427", "l": "Expression of peptide bound class I MHC on cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65209", "l": "(3S)-3-hydroxybutanoyl-CoA + H2O => (S)-3-hydroxybutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.124", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450348", "l": "Activated human JNKs migrate to nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3785684", "l": "Fibronectin degradation by CTSG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54510", "l": "beta-heptaprene + diphosphate => all-trans-heptaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23875", "l": "(R)-propane-1,2-diol + NAD(+) <=> (R)-lactaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735442", "l": "FOXO4, MEF2C, and NKX2-5 bind the MYOCD gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803719", "l": "TP53 binds ZNF385A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15512", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27976", "l": "7-carboxy-7-deazaguanine + NH4(+) => 6-carboxy-5,6,7,8-tetrahydropterin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74545", "l": "(E,E,E)-alpha-springene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47061", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42951", "l": "cytidine(48) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73896", "l": "ATP + L-glutamate + spermine => ADP + gamma-L-glutamylspermine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15831", "l": "a 16beta-hydroxysteroid => a 16alpha-hydroxysteroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634228", "l": "TRAF1 is cleaved by caspases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0031369", "l": "translation initiation factor binding", "d": ["Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202731", "l": "JAM3 dimerises (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983259", "l": "Kinesins move along microtubules consuming ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51575", "l": "(25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008805", "l": "carbon-monoxide oxygenase activity", "d": ["Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8963851", "l": "VD3 dissociates from GC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66351", "l": "3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A <=> (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622981", "l": "NPY gene expression is stimulated by FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37617", "l": "1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018687", "l": "biphenyl 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+. This reaction requires Fe2+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451033", "l": "(S)-Malate <=> Fumarate + H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51857", "l": "(E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out) => (2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031996", "l": "thioesterase binding", "d": ["Binding to a thioesterase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32918", "l": "sn-glycero-3-phospho-1D-myo-inositol(out) <=> sn-glycero-3-phospho-1D-myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41612", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O = D-ribose 2,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30503", "l": "H2O + N-acetyl-L-glutamate 5-semialdehyde = acetate + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18774", "l": "coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid protein] => Co(I)-[methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33243", "l": "L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15062", "l": "2 a Fe(II)-siderophore + H(+) + NAD(+) => 2 a Fe(III)-siderophore + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "58.519156629725146", "identifiers": [{"i": "GO:0016747", "l": "acyltransferase activity, transferring groups other than amino-acyl groups", "d": ["Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610752", "l": "GLI3R translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008765", "l": "UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity", "d": ["Catalysis of the reaction: meso-2,6-diaminopimelate + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61451", "l": "H(+) + NADPH + O2 + tigecycline <=> 11a-hydroxytigecycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419428", "l": "S1PR2-5 bind S1P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55903", "l": "chloride + FADH2 + L-tryptophan + O2 <=> 6-chloro-L-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432533", "l": "PP1 binds to phosphorylated TIM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864569", "l": "WWOX binds TFAP2C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75691", "l": "2'-deoxyadenosine(in) = 2'-deoxyadenosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.57", "l": "\"taurochenodeoxycholate 6alpha-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72431", "l": "(E)-caffeate + ATP + H(+) = (E)-caffeoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55614", "l": "1-methyladenine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+) => an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30759", "l": "5-methylcytosine + H(+) + H2O = NH4(+) + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52182", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354173", "l": "Activation of Rap1 by cytosolic GEFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74676", "l": "AH2 + archaeol + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaeol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5688797", "l": "ATXN3 family cleave Ub chains (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379464", "l": "COMT transfers Met to DOPAC to form HVA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824219", "l": "Expression of NOTCH1 in paraxial mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64444", "l": "L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.368", "l": "\"[histone H3]-lysine(9) N-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5681980", "l": "ATG12 binds ATG7 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20897", "l": "ATP + hydrogencarbonate + urea => ADP + H(+) + phosphate + urea-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210444", "l": "L-Glutamate loading of synaptic vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52116", "l": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74349", "l": "O-acyl-(R)-carnitine(out) => O-acyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254291", "l": "ERBB4s80 binds STAT5A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004328", "l": "formamidase activity", "d": ["Catalysis of the reaction: formamide + H2O = formate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68178", "l": "CO2 + dainate A + H2O + succinate => 2-oxoglutarate + N-geranyl-L-glutamate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111956", "l": "Calmodulin activates Cam-PDE 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14394", "l": "N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603419", "l": "Activated NTRK3 binds SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11813", "l": "H2O + methanethiol + O2 => formaldehyde + H(+) + H2O2 + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193997", "l": "CYP11B1 oxidises 11DCORT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54108", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + guaia-4,6-diene", "d": []}, {"i": "EC:4.2.3.179", "l": "\"guaia-4,6-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64919", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018798", "l": "RHOV binds GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350058", "l": "Formation of CSL NCOR corepressor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56819", "l": "a pyrimidine ribonucleoside + H2O <=> a pyrimidine nucleobase + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690873", "l": "ACO1 binds 4Fe-4S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67237", "l": "mycophenolyl-CoA + propanoyl-CoA => (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63051", "l": "H2O + pravastatin lactone <=> H(+) + pravastatin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047001", "l": "2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 2-dehydro-3-deoxy-D-gluconate = NADH + (4S)-4,6-dihydroxy-2,5-dioxohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749320", "l": "CDT1-mediated loading of MCM2-7 to replication origins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14697", "l": "(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.216", "l": "\"farnesol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879459", "l": "F-actin capping protein is a heterodimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61032", "l": "3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine = 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.160", "l": "\"caffeine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23763", "l": "H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038186", "l": "lithocholic acid receptor activity", "d": ["Combining with lithocholic acid and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696183", "l": "AOC3 deaminates BZAM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052614", "l": "uracil oxygenase activity", "d": ["Catalysis of the reaction: uracil + NADH + O2 + H+ = ureidoacrylate peracid + NAD+. Ureidoacrylate peracid is spontaneously reduced by NADH to form ureidoacrylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20666", "l": "1,5-anhydro-D-glucitol + NADP(+) => 1,5-anhydro-D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42833", "l": "(2E)-octenal + H(+) + pyruvate => (S)-3-acetyloctanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40952", "l": "(2S)-2-acetamido-4-aminobutanoate + H2O => acetate + L-2,4-diaminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295599", "l": "SPRY2 translocates to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66442", "l": "but-3-en-2-one + H(+) + NADPH => butan-2-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23762", "l": "reduced coenzyme F420-(gamma-L-Glu)(n) => H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61645", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine => 2 Fe(III)-[cytochrome b5] + H2O + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.16", "l": "\"D-alanine--alanyl-poly(glycerolphosphate) ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161735", "l": "PGC2 is isomerised to PGB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61955", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800250", "l": "TP53 stimulates BCL6 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033823", "l": "procollagen glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19165", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose = 1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.208", "l": "\"diglucosyl diacylglycerol synthase (1,2-linking)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22971", "l": "butanal + CoA + NAD(+) <=> butanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43351", "l": "cholesteryl (9Z-octadecenoate)(in) <=> cholesteryl (9Z-octadecenoate)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654409", "l": "Activated FGFR3 binds FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1013020", "l": "Activation of GIRK/Kir3 Channels (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44198", "l": "3-methylundecanoyl-CoA + AMP + diphosphate => 3-methylundecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46258", "l": "a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9728664", "l": "GLP1R binds GLP1R agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851890", "l": "MET phosphorylates SHC1-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64134", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine => H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65231", "l": "(1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+) <=> H(+) + NADPH + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54346", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33858", "l": "an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose <=> a mannosylinositol-1-phosphophytoceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72776", "l": "7-carboxymellein + ATP + L-phenylalanine => ADP + H(+) + ochratoxin B + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51580", "l": "a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) = a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26256", "l": "H(+) + isopimara-7,15-dienol + NADPH + O2 <=> 2 H2O + isopimara-7,15-dienal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029473", "l": "Branching and elongation of mother and daughter filaments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38687", "l": "(4R)-hydroxysphinganine(in) + ATP + H2O = (4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174255", "l": "Degradation multiubiquitinated Cyclin A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41702", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+) => 1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419253", "l": "5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42250", "l": "3-oxohexanoyl-[ACP] + CO2 + CoA => butanoyl-CoA + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8980691", "l": "RHOA GEFs activate RHOA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004048", "l": "anthranilate phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034843", "l": "2-oxoglutaryl-CoA thioesterase activity", "d": ["Catalysis of the reaction: 2-oxoglutaryl-CoA + OH- = 2-oxoglutarate + CoASH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53788", "l": "allodeoxycholoyl-CoA + beta-muricholate = allodeoxycholate + beta-muricholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449058", "l": "Interleukin-1 family are secreted (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686625", "l": "LAIR1 binds collagen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954082", "l": "E2F6 binds the PRC1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141367", "l": "Myristoylation of tBID by NMT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54598", "l": "2-hydroxyhexadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + hexadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709366", "l": "CO translocates from cytosol to mitochondrial inner membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32232", "l": "(6S)-NADPHX + ATP => ADP + H(+) + NADPH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45314", "l": "H(+) + NADPH + prostaglandin H2 => NADP(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29903", "l": "ATP + D-ribose(out) + H2O = ADP + D-ribose(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.5.2.7", "l": "\"ABC-type D-ribose transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047084", "l": "methyltetrahydroprotoberberine 14-monooxygenase activity", "d": ["Catalysis of the reaction: O2 + NADPH + H+ + (S)-N-methylcanadine = H2O + NADP+ + allocryptopine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757578", "l": "ALB binds PREDN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209840", "l": "Two DITs combine to form thyroxine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11858", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981606", "l": "Myoglobin binds oxygen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694409", "l": "Nucleotide exchange on RAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35184", "l": "5-hydroxythiophene-2-carbonyl-CoA + H2O => 4-carboxy-2-thioxobutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52504", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = (9R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55595", "l": "2 (3R)-hydroxydecanoyl-[ACP] + H2O <=> (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60298", "l": "H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0003951", "l": "NAD+ kinase activity", "d": ["Catalysis of the reaction: ATP + NAD+ = ADP + 2 H+ + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374681", "l": "L1 and NCAM1 engaged in cis-interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396370", "l": "VTN binds collagens II, III and V (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000074", "l": "TCN2 binds RCbl in the circulation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351849", "l": "Caspase-mediated cleavage of Etk (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.25", "l": "\"cucumisin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51002", "l": "[fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine => [fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848829", "l": "CBL autoubiquitinates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018659", "l": "4-hydroxybenzoate 3-monooxygenase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805479", "l": "TP53RK phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49985", "l": "H(+) + jasmonate + NADPH + O2 => (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29088", "l": "(S)-malate + menaquinone-8 => menaquinol-8 + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045135", "l": "poly(beta-D-mannuronate) lyase activity", "d": ["Catalysis of the reaction: polysaccharides containing beta-D-mannuronate residues = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62645", "l": "(5Z,8Z)-eicosadienoate + O2 => (5S)-hydroperoxy-(6E,8Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13546", "l": "(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] => (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941312", "l": "TUT4,TUT7 oligouridylate mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54590", "l": "H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine in 25S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29082", "l": "(R)-lactate + ubiquinone-8 <=> pyruvate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798528", "l": "S100A8:S100A9 binds Mn2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-606326", "l": "HJURP:CENPA complex localizes to the centromere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9704297", "l": "CHRM2 binds CHRM2 antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64935", "l": "dGTP + 2 H2O <=> dGMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0140327", "l": "flippase activity", "d": ["Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23210", "l": "(2E)-glutaconyl-CoA + acetate => acetyl-CoA + trans-glutaconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50927", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 <=> (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18240", "l": "2,5-dihydroxybenzoate + O2 <=> 3-maleylpyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21818", "l": "a 2-oxocarboxylate + H2O2 + NH4(+) => a D-alpha-amino acid + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047122", "l": "quinaldate 4-oxidoreductase activity", "d": ["Catalysis of the reaction: A + H2O + quinaldate = AH(2) + kynurenate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73333", "l": "cimicifugate E + CoA => (2R,3S)-piscidate + (E)-feruloyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247569", "l": "PADI4 deiminates Histones (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44546", "l": "a fatty acid(in) + ADP + H(+) + phosphate => a fatty acid(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.38", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52582", "l": "ADP + H(+) + Pb(2+)(out) + phosphate => ATP + H2O + Pb(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19372", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351429", "l": "Association of 53BP1 with gamma H2AX at double strand break (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71247", "l": "beta-alanine(out) + chloride(out) + 2 Na(+)(out) = beta-alanine(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21015", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67971", "l": "H2O + presqualene diphosphate <=> H(+) + phosphate + presqualene monophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27510", "l": "7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine = dehydro coenzyme F420-0 + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74870", "l": "(E)-caffeyl aldehyde + CoA + NADP(+) <=> (E)-caffeoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10707", "l": "ATP + L-valine + tRNA(Val) <=> AMP + diphosphate + L-valyl-tRNA(Val)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65965", "l": "ATP + H2O + taurocholate(out) => ADP + H(+) + phosphate + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38557", "l": "a fatty acid + all-trans-retinol + H(+) => an all-trans-retinyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30098", "l": "(S)-malate + a menaquinone <=> a menaquinol + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60414", "l": "[N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+) => H2O + monoglucosyl-enterobactin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18202", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69539", "l": "alpha-D-tagatopyranose 1-phosphate + ATP <=> ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12819", "l": "biochanin A + 2 H(+) + NADPH => 2,3-dihydrobiochanin A + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202245", "l": "Phosphorylation of TBSMs in LAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696670", "l": "CHD1L is recruited to GG-NER site (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28432", "l": "D-allulose 6-phosphate => D-allose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68248", "l": "L-tyrosine(in) + Na(+)(in) = L-tyrosine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12676", "l": "an aliphatic amide <=> a nitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61088", "l": "(S)-eriodictyol + 2-oxoglutarate + O2 = (2R,3R)-dihydroquercetin + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33429", "l": "bacillithiol + H2O => (S)-malyl alpha-D-glucosaminide + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50943", "l": "L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) <=> cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20382", "l": "androsterone + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13958", "l": "4 H2O + O2 + 4 sulfur => 6 H(+) + 2 hydrogen sulfide + 2 sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004813", "l": "alanine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35357", "l": "(2E)-13-methyltetradecenoyl-CoA + H2O => 3-hydroxyisopentadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9702849", "l": "CALCR binds gepants (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034598", "l": "phosphothreonine lyase activity", "d": ["Catalysis of the removal of the phosphate group from phosphothreonine by cleavage of the C-OP bond with the concomitant abstraction of the alpha proton, generating a double bond-containing product."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047658", "l": "alpha-amino-acid esterase activity", "d": ["Catalysis of the reaction: an alpha-amino acid ester + H2O = an alpha-amino acid + an alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012542", "l": "IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42094", "l": "all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047080", "l": "deoxyuridine 2'-dioxygenase activity", "d": ["Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O2 = CO2 + succinate + uridine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004676", "l": "3-phosphoinositide-dependent protein kinase activity", "d": ["Phosphatidylinositol-3-phosphate-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."]}, {"i": "REACT:R-HSA-437195", "l": "PDPK1 activates PRKCZ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690785", "l": "BAP1 binds Ub-HCFC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187506", "l": "Translocation of p27 to the nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692738", "l": "HRH2 binds HRH2 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218815", "l": "p-6Y-VEGFR2 binds NCK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39404", "l": "(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH => (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983147", "l": "Release of E3 from polyubiquitinated substrate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156699", "l": "Inactivation of Wee1 kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14476", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) <=> a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032448", "l": "DNA hairpin binding", "d": ["Binding to a DNA region containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46805", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine => a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71589", "l": "(S)-malate(out) + 2-oxoglutarate(in) => (S)-malate(in) + 2-oxoglutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51581", "l": "a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) => a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55899", "l": "chloride + FADH2 + L-tryptophan + O2 <=> 5-chloro-L-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61853", "l": "campesterol + UDP-alpha-D-glucose => campesteryl 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625416", "l": "Anterograde IFT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730858", "l": "Autophosphorylation of BTK/ITK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30031", "l": "(S)-muconolactone = cis,cis-muconate + H(+)", "d": []}, {"i": "EC:5.5.1.1", "l": "\"muconate cycloisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36064", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + kunzeaol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204863", "l": "Interaction of Tie2 with Ang2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39637", "l": "(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+) => 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38795", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28012", "l": "propanoate + succinyl-CoA => propanoyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27340", "l": "2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] <=> 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53730", "l": "N-acetyl-D-muramate + phosphate => H2O + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047873", "l": "dolichyl-phosphatase activity", "d": ["Catalysis of the reaction: dolichyl phosphate + H2O = dolichol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20031", "l": "H(+) + NADPH + vellosimine => 10-deoxysarpagine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614787", "l": "MPZ gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623999", "l": "BCL gene expression downstream of ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54479", "l": "1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052922", "l": "hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696491", "l": "CNTF binds CNTFR complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395340", "l": "Formation of hydroxyallysine by LOX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40267", "l": "(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) = 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25024", "l": "CTP + riboflavin <=> CDP + FMN + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061714", "l": "folic acid receptor activity", "d": ["Combining selectively with extracellular folic acid and delivering it into the cell via endocytosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72897", "l": "4-O-demethylbarbatate + 6 CO2 + 8 CoA + H2O + 2 S-adenosyl-L-homocysteine => 2 acetyl-CoA + 3 H(+) + 6 malonyl-CoA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67300", "l": "(5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one = 3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58715", "l": "NADH + O2 + rifampicin <=> H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63389", "l": "2 A + Fe(II)-heme o + H2O => 2 AH2 + Fe(II)-heme a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64938", "l": "dGDP + H(+) + phosphate => dGTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30737", "l": "myo-inositol + phosphate => 1D-myo-inositol 4-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49359", "l": "2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39721", "l": "24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69565", "l": "12 ATP + L-asparagine + L-aspartate + L-cysteine + L-glutamate + L-histidine + 3 L-isoleucine + L-leucine + L-lysine + L-ornithine + L-phenylalanine => 12 AMP + bacitracin A + 12 diphosphate + 12 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "46.625015130577331", "identifiers": [{"i": "GO:0005488", "l": "binding", "d": ["The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48467", "l": "ganglioside GM1b + H2O <=> ganglioside GA1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55459", "l": "ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0005355", "l": "glucose transmembrane transporter activity", "d": ["Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71093", "l": "dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in) => dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419166", "l": "GEFs activate RhoA,B,C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1248002", "l": "Ligand-independent dimerization of EGFRvIII mutant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59705", "l": "D-cellohexaono-1,5-lactone + H2O => D-cellohexaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46384", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24984", "l": "(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35807", "l": "2-dehydro-3-deoxy-D-arabinonate = 2,5-dioxopentanoate + H2O", "d": []}, {"i": "EC:4.2.1.141", "l": "\"2-dehydro-3-deoxy-D-arabinonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12860", "l": "(2S,3S)-3-methyl-L-aspartate <=> L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689861", "l": "Recruitment of XPA and release of CAK  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66701", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46816", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42584", "l": "1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56919", "l": "3beta-hydroxy-5alpha-androstan-17-one + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67009", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2299677", "l": "SCARA5:ligand is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37720", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56095", "l": "bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865320", "l": "CBFB binds RUNX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390597", "l": "Release Of ADP From Myosin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27363", "l": "chloromethane + S-adenosyl-L-homocysteine => chloride + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63207", "l": "H2O + octadecanoyl-[ACP] <=> H(+) + holo-[ACP] + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27705", "l": "aldehydo-D-galacturonate <=> keto-D-tagaturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11870", "l": "D-ribulose + H(+) + NADPH => D-arabinitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54345", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49070", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin] => 25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62278", "l": "6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine => 3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982617", "l": "CYGB:O2 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371422", "l": "ATP hydrolysis by HSP70 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69664", "l": "H2O + luteolin 7-O-beta-D-glucoside => beta-D-glucose + luteolin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106080", "l": "GATOR1 complex binding", "d": ["Binding to a GATOR1 complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30310", "l": "7-methylxanthine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975633", "l": "atROL binds to RBP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3244643", "l": "STING binds cyclic GMP-AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944454", "l": "mTORC1 phosphorylates MAF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204861", "l": "Interaction of Tie2 and Shc1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.155", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67565", "l": "3'-phosphoadenylyl sulfate + chenodeoxycholate => adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75830", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] <=> (5S,18)-dihydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39418", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH <=> (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.378002841413903", "identifiers": [{"i": "GO:0015294", "l": "solute:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641111", "l": "Parkin transfers Ub to misfolded proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19515", "l": "H(+) + L-citrulline + phosphate => carbamoyl phosphate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483089", "l": "PE is converted to PS by PTDSS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098600", "l": "selenomethionine gamma-lyase activity", "d": ["Catalysis of the reaction: L-Selenomethionine + H2O => Methaneselenol + Ammonia + 2-oxobutanoic acid."]}, {"i": "REACT:R-HSA-2408537", "l": "Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40547", "l": "10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867041", "l": "EGFR phosphorylates EPS15 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047298", "l": "(S)-3-amino-2-methylpropionate transaminase activity", "d": ["Catalysis of the reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399712", "l": "Activation of Ca permeable AMPA receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396029", "l": "Latent TGF-beta-3 binds integrins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47812", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15121", "l": "dithioerythritol + thiosulfate = cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite", "d": []}, {"i": "EC:2.8.1.5", "l": "\"thiosulfate--dithiol sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944254", "l": "Association of procollagen type XXVI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013004", "l": "RHOA binds effectors at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140061", "l": "5-hydroxymethylcytosine dioxygenase activity", "d": ["Catalysis of the reaction: 5-hydroxymethylcytosine + 2-oxoglutarate + O2 = 5-formylcytosine + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64404", "l": "carnosine(out) + H(+)(out) = carnosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62707", "l": "glycyldehydrophenylalanine + H2O <=> 2,3-didehydrophenylalanine + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28515", "l": "(R)-carnitine + ATP + CoA => (R)-carnitinyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009702", "l": "L-arabinokinase activity", "d": ["Catalysis of the reaction: L-arabinose + ATP = beta-L-arabinose 1-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35002", "l": "ADP(in) + ATP(out) <=> ADP(out) + ATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74970", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + H(+) <=> a (3R)-3-isocyanyl-fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11478", "l": "glycerol + phosphate => glycerol 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982017", "l": "Active G alpha (q) binds RGS proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.3.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74716", "l": "Insulin binds the insulin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70468", "l": "2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in double-stranded DNA + H2O + O2 => a 2'-deoxycytidine in double-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69639", "l": "H2O + phlorizin = beta-D-glucose + phloretin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803890", "l": "SFN dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68391", "l": "2 5,6-dihydroxyindole-2-carboxylate + O2 <=> 2 H2O + 2 indole-5,6-quinone-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682388", "l": "Autophagosome maturation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21579", "l": "carnitine + H(+) <=> 2-methylcholine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17335", "l": "acetate + H(+) + L-lupinate => O-acetyl-L-serine + zeatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57692", "l": "2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 cob(I)inamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58394", "l": "4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757451", "l": "ASA-,ST translocate from cytosol to ER lumen of hepatocytes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47797", "l": "an aralkylamine + H2O + 2 oxidized [azurin] => an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008794", "l": "arsenate reductase (glutaredoxin) activity", "d": ["Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684052", "l": "PIAS4 SUMOylates MDC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-879459", "l": "F-actin capping protein is a heterodimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023451", "l": "FGFR1c P252X mutants bind ligand with enhanced affinity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51830", "l": "AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in) => ATP(in) + CoA(in) + docosanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59700", "l": "D-cellopentaono-1,5-lactone + H2O = D-cellopentaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48707", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> 12S-HpEPE", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3240957", "l": "Formation of PRC2-EZH2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43923", "l": "(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21322", "l": "AH2 + keto-L-sorbose => A + D-sorbitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13339", "l": "D-glucuronate + H(+) => D-glucurono-6,2-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43321", "l": "1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74680", "l": "UDP-beta-L-arabinofuranose(in) + UMP(out) => UDP-beta-L-arabinofuranose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693598", "l": "ATM phosphorylates NBN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950504", "l": "IL27 binds CRLF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34573", "l": "H(+) + NADPH + presqualene diphosphate => C30 botryococcene + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4647593", "l": "EP400 binds CDKN1A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21046", "l": "(Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine => 24-methylidenelophenol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68220", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol = (7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114552", "l": "Thrombin-activated PARs activate G12/13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9692880", "l": "HRH3 binds Hist (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759158", "l": "SQSTM1 oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12077", "l": "an aromatic primary alcohol + NAD(+) => an aromatic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669012", "l": "EDA binds EDAR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72752", "l": "H2O + ochratoxin A => L-phenylalanine + ochratoxin alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22743", "l": "ATP + D-hexose <=> ADP + D-hexose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982765", "l": "Growth hormone forms dimers and oligomers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37445", "l": "1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46817", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27544", "l": "4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde => methanol + N,N-dimethyl-4-nitrosoaniline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31140", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) => 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35428", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside => (E)-sinapate + cyanidin 3,5-di-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74803", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15190", "l": "2 Fe(III)-[cytochrome c553] + formate => CO2 + 2 Fe(II)-[cytochrome c553] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0005172", "l": "vascular endothelial growth factor receptor binding", "d": ["Binding to a vascular endothelial growth factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23244", "l": "propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + norspermidine + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.23", "l": "\"sym-norspermidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.77", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22909", "l": "3',5'-cyclic AMP + H(+) + H2O => 3',5'-cyclic IMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0097153", "l": "cysteine-type endopeptidase activity involved in apoptotic process", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process."]}, {"i": "REACT:R-HSA-6800797", "l": "The PIDDosome activates CASP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847534", "l": "RAB43 hydrolyses GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371591", "l": "Trimerization of cytosolic HSF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19109", "l": "1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)", "d": []}, {"i": "EC:2.3.1.143", "l": "\"beta-glucogallin--tetrakisgalloylglucose O-galloyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39020", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32364", "l": "L-gulono-1,4-lactone + O2 => H(+) + H2O2 + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44575", "l": "4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+) <=> 2-all-trans-heptaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62259", "l": "Cd(2+)(out) + 2 hydrogencarbonate(out) <=> Cd(2+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382054", "l": "PDGF binds to extracellular matrix proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54687", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (-)-kolavenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727919", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to 14-3-3 proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022852", "l": "glycine-gated chloride ion channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50339", "l": "O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate <=> H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46514", "l": "an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O => an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59257", "l": "Fe(III)-enterobactin + H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682709", "l": "LGI4 binds ADAM22,23,11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62612", "l": "adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047693", "l": "ATP diphosphatase activity", "d": ["Catalysis of the reaction: ATP + H2O = AMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19122", "l": "an S-substituted glutathione(in) + ATP + H2O => ADP + an S-substituted glutathione(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71223", "l": "chloride(out) + 2 Na(+)(out) + taurine(out) = chloride(in) + 2 Na(+)(in) + taurine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-984733", "l": "Kinesin-3 is a dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42502", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668335", "l": "CHMP7 binds LEMD2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222407", "l": "Superoxide and nitric oxide react to peroxynitrite (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69391", "l": "(S)-2-ureidoglycine + carbamoyl phosphate <=> allantoate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35832", "l": "2-oxoglutarate + kanamycin B + O2 => 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16189", "l": "3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate", "d": []}, {"i": "EC:1.13.11.27", "l": "\"4-hydroxyphenylpyruvate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37746", "l": "dimethylallyl phosphate + FMNH2 <=> phosphate + prenyl-FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74111", "l": "H(+) + hypotaurine + NADH + O2 = H2O + NAD(+) + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13015", "l": "an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16956", "l": "2-oxoglutarate + N(2)-succinyl-L-ornithine <=> L-glutamate + N-succinyl-L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51087", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30691", "l": "H2O2 + methanol = formaldehyde + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14113", "l": "a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O = a 3'-end 2'-deoxyribonucleotide-DNA + phosphate", "d": []}, {"i": "EC:3.1.3.32", "l": "\"polynucleotide 3'-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74033", "l": "L-alanine(out) + L-cysteine(in) => L-alanine(in) + L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52599", "l": "lithocholoyl-CoA + NAD(+) <=> 3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40638", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O <=> 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420688", "l": "GABAB heterodimeric receptor binds GABA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.-", "l": "\"Peptidylamino-acid hydrolases or acylamino-acid hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58452", "l": "N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950778", "l": "p-Y693-STAT4 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615910", "l": "SUMOylation of PCNA with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22803", "l": "cycloeucalenol <=> obtusifoliol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63494", "l": "menadiol + NADP(+) => H(+) + menadione + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.265", "l": "\"phosphatidylinositol dimannoside acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696268", "l": "RND3 binds effectors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.152", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42654", "l": "diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62456", "l": "ATP + H(+) + L-glutamate = diphosphate + L-glutamyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797810", "l": "PTPRD binds IL1RAPL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70987", "l": "beta-alanine(out) + n H(+)(in) = beta-alanine(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668831", "l": "CST complex formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614614", "l": "Cysteine is degraded to serine and H2S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050697", "l": "1,1,2-trichloroethene reductive dehalogenase activity", "d": ["Catalysis of the reaction: trichloroethene + 2 H+ + 2 e- = HCl + 1,2-dichloroethene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32797", "l": "ADP + H(+) + L-cysteine(in) + phosphate => ATP + H2O + L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19687", "l": "CoA + H(+) + N-[(E)-feruloyl]tyramine => (E)-feruloyl-CoA + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41648", "l": "aniline + ATP + L-glutamate = ADP + N(5)-phenyl-L-glutamine + phosphate", "d": []}, {"i": "EC:6.3.1.18", "l": "\"gamma-glutamylanilide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76031", "l": "2-oxoglutarate + O2 + thebaine = 3-O-demethylthebaine + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41187", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41014", "l": "(+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) <=> (+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388828", "l": "PD-1 binds B7DC and B7H1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943811", "l": "MECOM (EVI1) binds the PTEN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701485", "l": "Active ALK binds JAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71450", "l": "D-alanine(in) + Na(+)(in) <=> D-alanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692867", "l": "HRH3 binds pitosilant (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193801", "l": "Influx of 27-hydroxycholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67869", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] => 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2530445", "l": "CD59 inhibits MAC formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013109", "l": "RHOC GEFs activate RHOC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166220", "l": "FA anion diffuses laterally to UCP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071860", "l": "proctolin receptor binding", "d": ["Binding to a proctolin receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015535", "l": "fucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fucose(out) + H+(out) = fucose(in) + H+(in)."]}, {"i": "RHEA:29023", "l": "H(+)(in) + L-fucose(in) = H(+)(out) + L-fucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5333051", "l": "RPA1 binds HSF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707505", "l": "Hemes bind to CLEC1B dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374686", "l": "L1 interaction with Integrins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626228", "l": "The distal appendage proteins recruit TTBK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83791", "l": "Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53409", "l": "(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 => (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61525", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23370", "l": "benzaldehyde + CO2 => H(+) + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66407", "l": "ATP + glutathione(in) + H2O + taurocholate(in) <=> ADP + glutathione(out) + H(+) + phosphate + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632412", "l": "PTK2 is recruited to methylated ESR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9736953", "l": "FURIN translocates to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1362416", "l": "Frataxin binds iron (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011961", "l": "GREB1 translation is negatively regulated by miR-26A and B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.444551060876734", "identifiers": [{"i": "GO:0016838", "l": "carbon-oxygen lyase activity, acting on phosphates", "d": ["Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71038", "l": "L-phenylalanine(out) + L-serine(in) <=> L-phenylalanine(in) + L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004802", "l": "transketolase activity", "d": ["Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74744", "l": "kaempferol + S-adenosyl-L-methionine => 3-O-methylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10657", "l": "guanidinoacetate + S-adenosyl-L-methionine => creatine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62807", "l": "2 7-demethylsiderin + NADPH + O2 <=> desertorin A + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-383190", "l": "HCO3- transport through ion channel (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64943", "l": "dGDP + H2O <=> dGMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416358", "l": "G alpha (q) inhibits PI3K alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59571", "l": "4-aminobutanoate + ATP + L-histidine <=> ADP + H(+) + L-homocarnosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73902", "l": "ATP + cadaverine + L-glutamate <=> ADP + gamma-L-glutamylcadaverine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28268", "l": "(S)-beta-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64651", "l": "(E)-coniferaldehyde + CoA + NADP(+) <=> (E)-feruloyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674398", "l": "D842V PDGFRA doesn't bind sunitinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40392", "l": "1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA => 1-O-alkyl-2,3-diacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1900750", "l": "oligopeptide binding", "d": ["Binding to an oligopeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36977", "l": "adenine + alpha-D-ribose 1,5-bisphosphate => AMP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66044", "l": "2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + H2O + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018758", "l": "RHOH binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183055", "l": "Binding of CBL to EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59498", "l": "(20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044373", "l": "cytokinin binding", "d": ["Binding to a cytokinin, any of a class of adenine-derived compounds that can function in plants as growth regulators."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3965450", "l": "DAAM1 recruits PFN1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31351", "l": "lupan-3beta,20-diol = (S)-2,3-epoxysqualene + H2O", "d": []}, {"i": "EC:4.2.1.128", "l": "\"lupan-3beta,20-diol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63137", "l": "adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione => cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-adenosylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63327", "l": "1,2-dihexadecanoyl-sn-glycerol + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65254", "l": "diphosphate + verruculide C => (2E,6E)-farnesyl diphosphate + 6-hydroxymellein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0016208", "l": "AMP binding", "d": ["Binding to AMP, adenosine monophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37096", "l": "(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39407", "l": "3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626681", "l": "Recruitment of transition zone proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.19", "l": "\"steroid 17alpha-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66344", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047487", "l": "oligogalacturonide lyase activity", "d": ["Catalysis of the reaction: 4-(4-deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665727", "l": "FMNL2 binds CDC42:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050587", "l": "chlorite O2-lyase activity", "d": ["Catalysis of the reaction: chloride + O2 = chlorite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63715", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428750", "l": "Gq activation by TP receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61233", "l": "H2O + L-isoleucine + O2 => (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0005280", "l": "amino acid:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in)."]}, {"i": "REACT:R-HSA-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030796", "l": "cycloartenol 24-C-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = (24R)-24-methylcycloart-25-en-3beta-ol + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429698", "l": "PRKD1,2,3 phosphorylates CERT1-2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66581", "l": "3'-phosphoadenylyl sulfate + bisphenol A => adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67864", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] = 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61061", "l": "beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose => a neolactoside nLc4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380930", "l": "Phosphorylated AMPK binds AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031434", "l": "mitogen-activated protein kinase kinase binding", "d": ["Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37911", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912374", "l": "Transport of NOTCH precursor to Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034541", "l": "dimethylarsinite methyltransferase activity", "d": ["Catalysis of the reaction: dimethylarsenous acid + R2S-CH3 = trimethylarsine oxide + R2SH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66334", "l": "L-aspartate(in) => L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16180", "l": "H2O + NAD(+) + retinal <=> 2 H(+) + NADH + retinoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45959", "l": "(9Z)-octadecenoyl-CoA(in) <=> (9Z)-octadecenoyl-CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35401", "l": "beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+) => 1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943279", "l": "GGT dimers hydrolyse GSH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50120", "l": "taurine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021520", "l": "NOTCH3 binds WWP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22286", "l": "CO2 + NH4(+) + putrescine => 2 H(+) + H2O + N-carbamoylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "58.646237807976007", "identifiers": [{"i": "GO:0003676", "l": "nucleic acid binding", "d": ["Binding to a nucleic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66525", "l": "L-ascorbate(in) + monodehydro-L-ascorbate radical(out) => L-ascorbate(out) + monodehydro-L-ascorbate radical(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113402", "l": "Formation of DSIF:NELF:early elongation complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64606", "l": "diphosphate + uridylyl-L-seryl-[protein] => L-seryl-[protein] + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839100", "l": "p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33779", "l": "6-kestotriose + sucrose = 6,6-kestotetraose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785722", "l": "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45085", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026579", "l": "NTRK2 phosphorylates PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45017", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine => L-selenomethionine + tetrahydropteroyltri-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684261", "l": "MAP3K8 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390116", "l": "Phospho FT reduces D accumulation at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33740", "l": "2 H(+) + hexadecanoate + NADH => H2O + hexadecanal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75737", "l": "10-oxo-(11E)-octadecenoate => 10-oxo-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332363", "l": "Autophosphorylation and activation of CAMK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0099085", "l": "DIF dechlorinase activity", "d": ["Catalysis of the reaction: 1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one => 1-[(3-chloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one + Cl-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3321975", "l": "NuA4 complex acetylates histone H2A, HIST1H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68236", "l": "L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.36", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112437", "l": "Formation of NELF complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201457", "l": "BMP2 binds to the receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18844", "l": "(R)-glycerate + NADP(+) <=> 2-hydroxy-3-oxopropanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51294", "l": "a quinol + L-methionyl-(S)-S-oxide-[protein] => a quinone + H2O + L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75430", "l": "eburicol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-hydroxyeburicol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806974", "l": "MET dimers autophosphorylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11409", "l": "H(+) + H2O + riboflavin => lumichrome + ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114352", "l": "Sequestration of tBID by BCL-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102753", "l": "chlorophyllide b:geranyl-geranyl diphosphate geranyl-geranyltransferase activity", "d": ["Catalysis of the reaction: H+ + chlorophyllide b(1-) + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate <=> geranylgeranyl-chlorophyll b + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33162", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49528", "l": "(ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)", "d": []}, {"i": "EC:3.1.1.101", "l": "\"poly(ethylene terephthalate) hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874078", "l": "PTK2 autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17262", "l": "an aryl sulfate + H2O => a phenol + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102729", "l": "6-oxocampestanol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + 6-oxocampestanol + O2 + NADPH = cathasterone + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070644", "l": "vitamin D response element binding", "d": ["Binding to a vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5610726", "l": "The IFT-A complex recruits TULP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168640", "l": "Ubiquitinated IkB is degraded (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1454928", "l": "ABCG4 may mediate cholesterol efflux (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70254", "l": "beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37906", "l": "6-hydroxytryprostatin B + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + tryprostatin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40795", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19567", "l": "diphosphate + sabinene hydrate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13661", "l": "H2O + N-formimidoyl-L-aspartate = N-formyl-L-aspartate + NH4(+)", "d": []}, {"i": "EC:3.5.3.5", "l": "\"formimidoylaspartate deiminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48638", "l": "15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782820", "l": "USP17 deubiquitinates SUDS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9676160", "l": "AAMP binds NOD2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9728664", "l": "GLP1R binds GLP1R agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57246", "l": "dGTP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75492", "l": "25-hydroxyvitamin D3 sulfate(out) + n H(+)(out) => 25-hydroxyvitamin D3 sulfate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071424", "l": "rRNA (cytosine-N4-)-methyltransferase activity", "d": ["Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine."]}, {"i": "RHEA:62520", "l": "a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659782", "l": "Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71953", "l": "3 Na(+)(in) + sulfate(in) => 3 Na(+)(out) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855195", "l": "I(1,3,4,5,6)P5 transports from the cytosol to the ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374686", "l": "L1 interaction with Integrins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61119", "l": "(2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.358732272612386", "identifiers": [{"i": "GO:0016702", "l": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20313", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.158", "l": "\"inositol-pentakisphosphate 2-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67792", "l": "ribonucleotidyl-uridine-RNA = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40035", "l": "ATP + L-glutamate + N-acetyl-L-aspartate = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate", "d": []}, {"i": "EC:6.3.2.41", "l": "\"N-acetylaspartylglutamate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67687", "l": "a long-chain fatty acid(in) + ATP + H2O <=> a long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11860", "l": "ATP + L-histidyl-[protein] = ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.13.2", "l": "\"protein-histidine tele-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793956", "l": "Defective B4GALT1 does not add Gal to N-glycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31552", "l": "presqualene diphosphate => 15-cis-4,4'-diapophytoene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52304", "l": "H2O + L-ectoine = (2S)-2-acetamido-4-aminobutanoate", "d": []}, {"i": "EC:3.5.4.44", "l": "\"ectoine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48135", "l": "(2E,6E)-farnesyl phosphate + H2O <=> (2E,6E)-farnesol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43691", "l": "N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate <=> L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10783", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) <=> 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59770", "l": "CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => hexadecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38819", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381109", "l": "IRE1 binds IRE1 forming dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694409", "l": "Nucleotide exchange on RAB1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50686", "l": "aniline + H(+) + L-glutamate => H2O + N(5)-phenyl-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46242", "l": "a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72835", "l": "3',3'-cUAMP + H2O = H(+) + U[3'-5']pAp[3']", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017151", "l": "DEAD/H-box RNA helicase binding", "d": ["Binding to a DEAD/H-box RNA helicase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953037", "l": "E2F8 forms homodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71272", "l": "H(+)(in) + thiamine(out) => H(+)(out) + thiamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11999", "l": "biphenyl-2-ol + H(+) + NADH + O2 <=> biphenyl-2,3-diol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140768", "l": "protein ADP-ribosyltransferase-substrate adaptor activity", "d": ["An enzyme-substrate adaptor that bings together a protein ADP-ribosyl transferase and its substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12254", "l": "(E)-coniferol + D-glucose => 4-O-(beta-D-glucosyl)-trans-coniferol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016403", "l": "dimethylargininase activity", "d": ["Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46156", "l": "15,9'-di-cis-phytofluene + a plastoquinone = 9,9',15-tri-cis-zeta-carotene + a plastoquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27273", "l": "CoA + hexadecanal + NADP(+) <=> H(+) + hexadecanoyl-CoA + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64998", "l": "diphosphate + octanoyl-AMP => ATP + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534359", "l": "CatSper Channel Mediated Calcium Transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73854", "l": "27-hydroxywithanone + UDP-alpha-D-glucose <=> H(+) + UDP + withanone 27-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66773", "l": "ATP + H2O + uroporphyrin I(in) => ADP + H(+) + phosphate + uroporphyrin I(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69238", "l": "4-hydroxybutylnitrile + sulfate + sulfur => (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15446", "l": "H(+) + H2O + O-carbamoyl-L-serine => CO2 + 2 NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379464", "l": "COMT transfers Met to DOPAC to form HVA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72119", "l": "(R)-carnitine(in) + glycine betaine(out) = (R)-carnitine(out) + glycine betaine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046863", "l": "ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity", "d": ["Binds to and iincreases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74162", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047046", "l": "homoisocitrate dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008672", "l": "2-dehydro-3-deoxyglucarate aldolase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64671", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0043821", "l": "propionyl-CoA:succinate CoA-transferase activity", "d": ["Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8960973", "l": "RLBP1:11cRAL dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683478", "l": "CQ, HCQ diffuses from cytosol to endocytic vesicle lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9015111", "l": "Factor Xa inhibitors binds Xa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11086", "l": "CO2 + L-xylulose => 3-dehydro-L-gulonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010643", "l": "AKAP5 recruits PKC to ROBO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2262743", "l": "Defective IDS does not hydrolyse dermatan sulfate (Chebi:63517 chain) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2399913", "l": "atRAL binds to RBP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853429", "l": "PHLDA1 binds AURKA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106615", "l": "Removal of siRNA passenger strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56758", "l": "4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983266", "l": "Kinesins bind microtubules (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20038", "l": "D-sorbitol 6-phosphate + NADP(+) => aldehydo-D-glucose 6-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1013020", "l": "Activation of GIRK/Kir3 Channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660980", "l": "p-S276-RELA binds RELB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39002", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14445", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32524", "l": "nigerose + phosphate => beta-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54989", "l": "4 e(-) + 4 H(+)(in) + O2(in) => 2 H2O(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13351", "l": "methyl (-)-jasmonate + S-adenosyl-L-homocysteine => jasmonate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49188", "l": "a bacteriochlorophyllide d = a 3-vinylbacteriochlorophyllide d + H2O", "d": []}, {"i": "EC:4.2.1.169", "l": "\"3-vinylbacteriochlorophyllide d 3(1)-hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19268", "l": "carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18261", "l": "H2O + precorrin-5 + S-adenosyl-L-methionine = acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.152", "l": "\"precorrin-6A synthase (deacetylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39155", "l": "(3R)-hydroxyoctadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48504", "l": "D-glycero-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-D-manno-heptose 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57028", "l": "FADH2 + N-methylnicotinate + O2 = (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63324", "l": "1,2-dihexadecanoyl-sn-glycerol + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17902", "l": "S-adenosyl-L-methionine + xanthotoxol => H(+) + S-adenosyl-L-homocysteine + xanthotoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21797", "l": "dTDP-beta-L-rhamnose + NADP(+) => dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42222", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39628", "l": "(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA => (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30628", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) => (2S)-2-acetolactate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73984", "l": "(2E,6E)-farnesyl diphosphate => (-)-beta-barbatene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418662", "l": "Src activation following P2Y purinoceptor activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71666", "l": "a menaquinone + 2 H(+)(out) + succinate <=> a menaquinol + fumarate + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73760", "l": "guanosine(2553) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2553) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71936", "l": "glycocholate(out) + 2 Na(+)(out) => glycocholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698013", "l": "PTPN11:p-STAT5 dissociates from mutant FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2314678", "l": "ASA- acetylates PTGS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17811", "l": "Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine => Mg-protoporphyrin IX + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036141", "l": "L-phenylalanine-oxaloacetate transaminase activity", "d": ["Catalysis of the reaction L-phenylalanine + oxaloacetate = phenylpyruvate + aspartate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797090", "l": "CCNK binds CDK12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69957", "l": "Ca(2+)(out) + 3 Na(+)(in) => Ca(2+)(in) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52603", "l": "L-methionine + propanoyl-CoA <=> CoA + H(+) + N-propanoyl-L-methioninate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44041", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => 14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446694", "l": "IRAK4 phosphorylates IRAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63406", "l": "6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O => 3,6-dichloropyridine-2,5-diol + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22577", "l": "an N-acyl-L-homoserine lactone + H2O => an N-acyl-L-homoserine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213207", "l": "Formation of collagen networks (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944215", "l": "Association of procollagen type XX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944250", "l": "Association of procollagen type XXV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047488", "l": "heparin lyase activity", "d": ["Catalysis of the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their nonreducing ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21540", "l": "N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate", "d": []}, {"i": "EC:5.3.1.24", "l": "\"phosphoribosylanthranilate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197963", "l": "DHFR2 reduces FOLA to DHF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10175", "l": "(3R)-hydroxybutanoate dimer + H2O <=> 2 (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40663", "l": "L-serine = 2-aminoprop-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37544", "l": "2-amino-5-chlorophenol + O2 => 2-amino-5-chloromuconate 6-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000831", "l": "inositol hexakisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66252", "l": "ATP + CoA + IC-asc-C7 = AMP + diphosphate + IC-asc-C7-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.14", "l": "\"glucuronan lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66709", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434836", "l": "Syk/Lck phosphorylate LAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754964", "l": "ADA deamidates RBV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46804", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine = a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.317", "l": "\"sphingolipid C(9)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14098", "l": "3-phenylpyruvate + L-aspartate => L-phenylalanine + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74727", "l": "acetyl-CoA + 10 H(+) + holo-[polyketide synthase] + 5 malonyl-CoA + 5 NADPH = 5 CO2 + 6 CoA + dodecapentaneoyl-[polyketide synthase] + 5 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213246", "l": "Disassociation of CLIP from MHC II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909718", "l": "Formation of p-STAT1 homodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68551", "l": "O2 + psoralen + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + xanthotoxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679028", "l": "JAK3 binds JAK3 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70227", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA = (E)-2-benzylidenesuccinyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.180", "l": "\"(E)-benzylidenesuccinyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43765", "l": "ATP + chenodeoxycholate + CoA => AMP + chenodeoxycholoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51933", "l": "2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite => 2 Fe(II)-[cytochrome c3] + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68305", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] => 3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11897", "l": "7alpha-hydroxycholesterol + NAD(+) => 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200646", "l": "Cytosolic folate export across the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24922", "l": "L-homoserine <=> 2-aminobut-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52393", "l": "ATP + D-erythronate => 4-phospho-D-erythronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56531", "l": "chloride + D-tryptophan + FADH2 + O2 <=> 6-chloro-D-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44610", "l": "2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160915", "l": "Receptor-mediated uptake of HA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.364", "l": "\"dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47833", "l": "ganglioside GD1a + H2O => ganglioside GM1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209921", "l": "Monoiodinated tyrosine can be deiodinated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68513", "l": "(2Z,6Z)-farnesyl diphosphate => alpha-acoradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69375", "l": "2-hydroxyhexanoate + O2 <=> 2-oxohexanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750226", "l": "NLRC5 binds IKBKB and CHUK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200396", "l": "Creatine transport across the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49564", "l": "D-sedoheptulose 7-phosphate = 2-epi-valiolone + phosphate", "d": []}, {"i": "EC:4.2.3.155", "l": "\"2-epi-valiolone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53852", "l": "glycocholate + NAD(+) = 7-oxo-glycodeoxycholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11011", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O <=> a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41161", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+) => 1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38771", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65043", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + a tri-(9Z,12Z-octadecadienoyl)-monolysocardiolipin <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50538", "l": "H2O + prostaglandin A2 => prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199043", "l": "LILRs interact with MHC Class I (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851352", "l": "CCR8 binds CCL1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809707", "l": "MTMR12 binds MTMR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043886", "l": "structural constituent of carboxysome shell", "d": ["The action of a molecule that contributes to the structural integrity of a carboxysome shell, an organelle found in all cyanobacteria and some chemoautotrophs, consisting of a proteinaceous coat and enzymes for the fixation of CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55870", "l": "H2O2 + pyruvate => (S)-lactate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203979", "l": "Coat Assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28464", "l": "pyridoxal(out) => pyridoxal(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52710", "l": "D-ribose 5-phosphate + guanine => GMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20744", "l": "NADP(+) + prostaglandin D2 = 15-oxoprostaglandin D2 + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.196", "l": "\"15-hydroxyprostaglandin-D dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57046", "l": "3-oxoisoapionate + H(+) + NADH => D-apionate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49077", "l": "dibenzothiophene + FMNH2 + O2 => dibenzothiophene 5-oxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20056", "l": "NAD(+) + ribitol <=> D-ribulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11524", "l": "5beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73995", "l": "geranylgeranyl diphosphate + H2O = (S)-(+)-nephthenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53594", "l": "1-tetradecanoyl-sn-glycerol + phosphate => 1-tetradecanoyl-sn-glycerol 3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14650", "l": "demethyllactenocin + dTDP-beta-L-mycarose => demethylmacrocin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694441", "l": "CSNK1D phosphorylates SEC23 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56921", "l": "a medium chain fatty acid + ATP + H(+) => a medium-chain fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75321", "l": "chloride(in) + D-alanine(in) + 2 Na(+)(in) => chloride(out) + D-alanine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047308", "l": "alanine-oxomalonate transaminase activity", "d": ["Catalysis of the reaction: L-alanine + oxomalonate = aminomalonate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865994", "l": "GAB1 binds PTPN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29179", "l": "a menaquinol + 2 O2 = a menaquinone + 2 H(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.958976004066542", "identifiers": [{"i": "GO:0030247", "l": "polysaccharide binding", "d": ["Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710306", "l": "GSDME expression mediated by TP53, TP63 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17930", "l": "an N-acylsphing-4-enine + ATP => ADP + an N-acylsphing-4-enine 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700179", "l": "Ligand-independent dimerization of ALK fusions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83677", "l": "C4 deamination of cytidine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446391", "l": "Formation of the PINCH-ILK-parvin complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55239", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O <=> (9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5252001", "l": "ATP1B4 binds SNW1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67363", "l": "H2O + L-threonyl-L-threonine <=> 2 L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71760", "l": "2-oxoglutarate(out) + heptanedioate(in) => 2-oxoglutarate(in) + heptanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46192", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34349", "l": "(2E)-geranial + H(+) + NADH => (2E)-geraniol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033431", "l": "CGA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CGA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38637", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683618", "l": "mRNA3 is translated to protein 3a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46602", "l": "[HPr protein]-O-phospho-L-serine + ADP + H(+) => [HPr protein]-L-serine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25691", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) => CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55257", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60122", "l": "H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine => (2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071890", "l": "bicarbonate binding", "d": ["Binding to bicarbonate ions (CHO3-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66400", "l": "ATP + glutathione(in) + glycocholate(in) + H2O = ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11589", "l": "A + H2O + isoquinoline => AH2 + isoquinolin-1(2H)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32968", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O => a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10903", "l": "an aromatic L-alpha-amino acid + glyoxylate <=> an aromatic oxo-acid + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57322", "l": "CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein] => acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483212", "l": "PS is decarboxylated to PE by PISD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65511", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2 <=> H2O2 + NH4(+) + pre-mycofactocin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35426", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417896", "l": "P2Y6 receptor can bind to UDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51706", "l": "4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + xanthohumol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55343", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol <=> 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035575", "l": "histone H4K20 demethylase activity", "d": ["Catalysis of the removal of the methyl group from a modified lysine residue at position 20 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}, {"i": "REACT:R-HSA-2172678", "l": "PHF8 demethylates histone H4K20me1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0048408", "l": "epidermal growth factor binding", "d": ["Binding to epidermal growth factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75437", "l": "14-demethyleburicol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 32-oxoeburicol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211734", "l": "Ubiquitination of PAK-2p34 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53572", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71465", "l": "Gly-L-Leu-L-Met-NH2 + substance P(1-8) => H2O + substance P", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9702849", "l": "CALCR binds gepants (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41913", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADPH => hexadecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0003730", "l": "mRNA 3'-UTR binding", "d": ["Binding to a 3' untranslated region of an mRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67824", "l": "a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O = a lipid X + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796368", "l": "RIPK1 binds STUB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672957", "l": "PP2A dephosphorylates KSR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30133", "l": "H(+) + holo-[ACP] + octanoate => H2O + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645598", "l": "RRAGC,D hydrolyzes GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951727", "l": "cAMP binds PKA tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209944", "l": "25(OH)D binds GC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939829", "l": "ITGBL1 gene expression is stimulated by RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36544", "l": "H2O + mycothiol S-conjugate => 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41221", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.19.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21341", "l": "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 => 2 vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030749", "l": "loganate O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36954", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2 <=> (9Z)-heptadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102689", "l": "UDP-glucose:isopentenyladenine 7-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + N(6)-dimethylallyladenine <=> H+ + 7-(alpha-D-glucosyl)-N(6)-isopentenyladenine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14443", "l": "CoA + H(+) + N(3)-acetylgentamycin C => acetyl-CoA + gentamicin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004551", "l": "dinucleotide phosphatase activity", "d": ["Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2203480", "l": "COLEC11 binds ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55351", "l": "all-trans-retinol <=> 9-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390663", "l": "ADRA2A,B,C bind ADR,NAd (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140488", "l": "heme receptor activity", "d": ["Binding specifically to heme to deliver it to a transport vesicle."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018771", "l": "2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity", "d": ["Catalysis of the reaction: (2E,4Z)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + H+ + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1977959", "l": "ERBB4 forms heterodimers with EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390663", "l": "ADRA2A,B,C bind ADR,NAd (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015192", "l": "L-phenylalanine transmembrane transporter activity", "d": ["Enables the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17186", "l": "IMP + NADP(+) + NH4(+) => GMP + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3134946", "l": "DDX41 ubiquitination by TRIM21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956684", "l": "ITCH polyubiquitinates TP73 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48819", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 <=> 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47694", "l": "5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B => AH2 + neomycin C + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19553", "l": "H2O + L-tryptophan = indole + NH4(+) + pyruvate", "d": []}, {"i": "EC:4.1.99.1", "l": "\"tryptophanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56449", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10871", "l": "a 1,2-diacyl-sn-glycerol + an acyl-CoA <=> a triacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22714", "l": "adenosylcob(III)inamide-GDP + diphosphate => adenosylcob(III)inamide phosphate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578777", "l": "DMPK phosphorylates PLN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482772", "l": "Release of platelet cytosolic components (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264622", "l": "Cho is acetylated to AcCho by CHAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199456", "l": "PTEN dephosphorylates PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25300", "l": "acetate + 2 H(+) + NADPH => acetaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610732", "l": "GSK3 phosphorylates p-GLI3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205244", "l": "Recruitment of CBL to KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1006169", "l": "Factor H binds host cell surface markers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38797", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626549", "l": "IQGAPs bind CALM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74326", "l": "O-3-hydroxybutanoyl-(R)-carnitine(in) <=> O-3-hydroxybutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49709", "l": "nocardicin G + S-adenosyl-L-methionine => H(+) + isonocardicin C + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097322", "l": "7SK snRNA binding", "d": ["Binding to a 7SK small nuclear RNA (7SK snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36251", "l": "(E)-ferulate + ATP + CoA = (E)-feruloyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033796", "l": "sulfur reductase activity", "d": ["Catalysis of the reduction of elemental sulfur or polysulfide to hydrogen sulfide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49434", "l": "choloyl-CoA + lithocholate => cholate + lithocholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851011", "l": "TRIM27 polyubiquitinates PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33587", "l": "acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate = CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "d": []}, {"i": "EC:2.3.1.201", "l": "\"UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67005", "l": "a 5'-end triphospho-ribonucleoside in mRNA + H2O => a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59564", "l": "H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone = H(+) + N,N',N'',N'''-tetraacetylchitotetraonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696183", "l": "AOC3 deaminates BZAM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005008", "l": "hepatocyte growth factor receptor activity", "d": ["Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73315", "l": "1D-chiro-inositol(out) + 2 Na(+)(out) = 1D-chiro-inositol(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12132", "l": "ATP + Cd(2+)(in) + H2O = ADP + Cd(2+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42548", "l": "uridine(746) in 23S rRNA = pseudouridine(746) in 23S rRNA", "d": []}, {"i": "EC:5.4.99.29", "l": "\"23S rRNA pseudouridine(746) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856525", "l": "ANGPTL8 binds ANGPTL3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55486", "l": "ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52473", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate => 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72348", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + veratrole => 3-methoxyphenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442749", "l": "CaMKK autophosphorylates in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55720", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981621", "l": "C3 convertases spontaneously dissociate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34617", "l": "H(+) + hydrogencarbonate + methylphosphonate => 2-hydroxyethylphosphonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60851", "l": "a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61556", "l": "gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102570", "l": "tyrosine:phenylpyruvate aminotransferase activity", "d": ["Catalysis of the reaction: keto-phenylpyruvate + L-tyrosine = L-phenylalanine + 3-(4-hydroxyphenyl)pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.47", "l": "\"(S)-hydroxynitrile lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68595", "l": "ORC2 binds ORC3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28031", "l": "[thioredoxin]-disulfide + dGDP + H2O => [thioredoxin]-dithiol + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29656", "l": "L-cysteine(in) => L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21386", "l": "(E)-cinnamate + NH4(+) => L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59165", "l": "ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] => AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912727", "l": "CBL binds VAV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867047", "l": "PTPN3 dephosphorylates EPS15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015099", "l": "nickel cation transmembrane transporter activity", "d": ["Enables the transfer of nickel (Ni) cations from one side of a membrane to the other."]}, {"i": "RHEA:29831", "l": "Ni(2+)(in) = Ni(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706344", "l": "FLT3 phosphorylates GRB10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374337", "l": "Apelin receptor binds to apelin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40861", "l": "(2E,9Z)-hexadecadienoyl-CoA + FADH2 => (9Z)-hexadecenoyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12659", "l": "a (2R)-2-methylacyl-CoA => a (2S)-2-methylacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65423", "l": "GMP(in) + NAD(+)(out) <=> GMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74414", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55659", "l": "2 A + a carotenoid beta-end derivative <=> a carotenoid chi-end derivative + 2 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72694", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) <=> 17beta-estradiol 17-O-(beta-D-glucuronate)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36445", "l": "6,8-dimethyl-6,7-didehydroergoline + H2O => dihydrochanoclavine-I aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618331", "l": "HDAC6 deacetylates microtubules (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67925", "l": "3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate => 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44278", "l": "4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA => eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-481007", "l": "Exocytosis of platelet alpha granule contents (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102529", "l": "apigenin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + apigenin-7-olate <=> S-adenosyl-L-homocysteine + genkwanin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28542", "l": "fluoroacetyl-CoA + H2O = CoA + fluoroacetate + H(+)", "d": []}, {"i": "EC:3.1.2.29", "l": "\"fluoroacetyl-CoA thioesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70844", "l": "L-arginine(in) + L-methionine(out) + Na(+)(out) => L-arginine(out) + L-methionine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44255", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174741", "l": "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68572", "l": "L-tyrosine(in) = L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733292", "l": "AMY1-3 bind pramlintide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31074", "l": "(S)-methylmalonate semialdehyde + L-alanine <=> (S)-3-amino-2-methylpropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46534", "l": "a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52843", "l": "UDP-alpha-D-glucose + vanillate <=> 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0005345", "l": "purine nucleobase transmembrane transporter activity", "d": ["Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71286", "l": "chloride(out) + L-glutamine(out) + 2 Na(+)(out) <=> chloride(in) + L-glutamine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443418", "l": "GP1b signaling involves c-Src (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35769", "l": "8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine => dihydrosterigmatocystin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050053", "l": "levansucrase activity", "d": ["Catalysis of the reaction: sucrose + 2,6-beta-D-fructosyl(n) = glucose + 2,6-beta-D-fructosyl(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16169", "l": "ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate", "d": []}, {"i": "EC:6.3.1.2", "l": "\"glutamine synthetase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-917700", "l": "MVB Vesicle Formation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22638", "l": "dCMP + diphosphate + H(+) => dCTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39483", "l": "3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166817", "l": "Cleavage of C3 by C3 convertases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38526", "l": "1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785594", "l": "FANCD2 binds FANCI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74958", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + holo-[ACP] <=> a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-437230", "l": "L1-FGFR cis-heterodimerization (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189439", "l": "ALAD condenses 2 dALAs to form PBG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156910", "l": "Formation of eEF1B complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59134", "l": "AMP + diphosphate + H(+) + staphyloferrin B => 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977375", "l": "CR1 binds C3bBb/C4bC2a (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1235035", "l": "Expression of Carbonic Anhydrase IX (CA9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38367", "l": "8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA = 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA", "d": []}, {"i": "EC:2.3.1.260", "l": "\"tetracycline polyketide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789092", "l": "NOX2 generates superoxide anion from oxygen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58950", "l": "4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.217", "l": "\"protodeoxyviolaceinate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16285", "l": "D-octopine + H2O + NAD(+) = H(+) + L-arginine + NADH + pyruvate", "d": []}, {"i": "EC:1.5.1.11", "l": "\"D-octopine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.178", "l": "\"methylxanthine N(1)-demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68339", "l": "(R)-4'-phosphopantetheine sulfonate + H2O <=> (R)-pantetheine sulfonate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0005251", "l": "delayed rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170120", "l": "Translocation of Cdc25B to the cytoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2509838", "l": "ITPA hydrolyses dITP to dIMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70267", "l": "hydrogencarbonate(in) + Na(+)(in) = hydrogencarbonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254291", "l": "ERBB4s80 binds STAT5A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029454", "l": "Autophosphorylation of PAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944246", "l": "Association of procollagen type XXI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626816", "l": "PIN1 binds p-S345-NCF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209177", "l": "ERF binds ETS2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9676264", "l": "Formation of the SET1B complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353444", "l": "Cleavage of thymine by TDG glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54255", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382053", "l": "Translocation of PDGF from ER to Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74154", "l": "acetyl-CoA + L-lysyl-[beta-tubulin] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[beta-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71503", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(in) = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9659820", "l": "RB1 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227694", "l": "dsRNA binds to MDA5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20101", "l": "a long-chain fatty acid + ATP + L-cysteinyl-[protein] = AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]", "d": []}, {"i": "EC:6.2.1.19", "l": "\"long-chain-fatty-acid--protein ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034784", "l": "pivalyl-CoA mutase activity", "d": ["Catalysis of the reaction: pivalyl-CoA = 3-methylbutyryl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47560", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) = CMP + ganglioside GM1b (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428273", "l": "SPHK1 phosphorylates SPG to S1P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14331", "l": "3-phosphooxypyruvate + L-glutamate => 2-oxoglutarate + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51642", "l": "(11R)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50644", "l": "2-(3-methylsulfanyl)propylmalate = 3-(3-methylsulfanyl)propylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102382", "l": "rebaudioside B glucosyltransferase activity", "d": ["Catalysis of the reaction: rebaudioside B + UDP-alpha-D-glucose <=> rebaudioside A + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1011598", "l": "DOCKs bind to RhoGEFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452108", "l": "Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35249", "l": "ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(out) + H(+) + phosphate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44090", "l": "AMP + diphosphate + heptanoyl-CoA => ATP + CoA + heptanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050194", "l": "phosphonoacetaldehyde hydrolase activity", "d": ["Catalysis of the reaction: H2O + phosphonoacetaldehyde = acetaldehyde + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26232", "l": "3 NADP(+) + phytyl diphosphate <=> geranylgeranyl diphosphate + 3 H(+) + 3 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74127", "l": "peonidin + UDP-alpha-D-galactose = peonidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047123", "l": "quinoline-4-carboxylate 2-oxidoreductase activity", "d": ["Catalysis of the reaction: A + H2O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15521", "l": "N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]", "d": []}, {"i": "EC:2.3.1.97", "l": "\"glycylpeptide N-tetradecanoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31472", "l": "beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1964496", "l": "STING binds TRIM32 or TRIM56  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0005363", "l": "maltose transmembrane transporter activity", "d": ["Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch."]}, {"i": "RHEA:33171", "l": "D-maltose(in) = D-maltose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878117", "l": "RUNX3 binds ZFHX3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51517", "l": "(R)-reticuline + S-adenosyl-L-methionine => (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16312", "l": "H2O + taurochenodeoxycholate <=> chenodeoxycholate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13713", "l": "a ubiquinone + succinate = a ubiquinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11444", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.9", "l": "\"chondro-4-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69072", "l": "H2O + O2 + serotonin = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19949", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate", "d": []}, {"i": "EC:2.5.1.15", "l": "\"dihydropteroate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3132759", "l": "TCN1 binds RCbl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73652", "l": "CTP(out) => CTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45112", "l": "gamma-tocopherol + H(+) + NADPH + O2 = 13-hydroxy-gamma-tocopherol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371435", "l": "Constitutive phosphorylation by GSK3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46838", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71791", "l": "(R)-lactate(in) + H(+)(in) = (R)-lactate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74888", "l": "2',3'-cGAMP(in) + ATP + H2O => 2',3'-cGAMP(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701488", "l": "Active ALK phosphorylates JAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56357", "l": "3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 => 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46038", "l": "dCMP + H(+) + UDP => 2'-deoxycytidine + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052580", "l": "(+)-pulegone reductase, (-)-menthone as substrate, activity", "d": ["Catalysis of the reaction: (-)-menthone + NADP+ = (+)-pulegone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672978", "l": "RAF phosphorylates MAP2K dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23189", "l": "NAD(+) + propane-1,3-diol => 3-hydroxypropanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009309", "l": "RUNX2 binds STUB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396234", "l": "Collagen type VII binds laminin-322 and collagen IV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24200", "l": "4-aminobenzoate + H(+) = aniline + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592371", "l": "Initial activation of proMMP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210271", "l": "Interaction of DAP12 and MDL-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73256", "l": "(2S)-sakuranetin + S-adenosyl-L-methionine => (2S)-naringenin 4',7-dimethyl ether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634897", "l": "NPAS4 binds CDK5R1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168400", "l": "iE-DAP elicits a NOD1 response (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863494", "l": "ASICs bind STOML3, (STOM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39116", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) => 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39688", "l": "(R)-3-hydroxy-(11Z)-octadecenoyl-CoA => (2E,11Z)-octadecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68237", "l": "L-glutamine(in) + Na(+)(in) => L-glutamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47790", "l": "a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in 28S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29536", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2029454", "l": "Autophosphorylation of PAK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54514", "l": "(13R)-9,13-epoxylabd-14-ene + diphosphate => peregrinol diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016608", "l": "growth hormone-releasing hormone activity", "d": ["The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624133", "l": "ARL3:GTP binds the UNC119B complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61618", "l": "formaldehyde + H2O + N-methyl-L-proline + NAD(+) => H(+) + L-proline betaine + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090722", "l": "receptor-receptor interaction", "d": ["The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216045", "l": "Collagen type I binds integrin alpha11beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50687", "l": "H2O + N(5)-phenyl-L-glutamine <=> aniline + H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015233", "l": "pantothenate transmembrane transporter activity", "d": ["Enables the directed movement of pantothenate across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050192", "l": "phosphoglycerate phosphatase activity", "d": ["Catalysis of the reaction: 2-phospho-D-glycerate + H2O = D-glycerate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445705", "l": "Release Of ADP From Myosin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209566", "l": "TRAF6 is auto-ubiquitinated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2173778", "l": "MSR1 (SCARA1, SR-A) binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202703", "l": "CD47 binds SIRP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509831", "l": "ITPA hydrolyses XTP to XMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939335", "l": "RNF181 polyubiquinates BCL10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71784", "l": "3-methyl-2-oxobutanoate(out) + H(+)(out) => 3-methyl-2-oxobutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665989", "l": "DIAPH1 binds RHOA:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209082", "l": "Further phosphorylation of APC by SGG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9704297", "l": "CHRM2 binds CHRM2 antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9650473", "l": "SERPING1 is secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35770", "l": "dihydrosterigmatocystin + S-adenosyl-L-methionine <=> 8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75732", "l": "(10S)-hydroxy-(12Z)-octadecenoate + NAD(+) => 10-oxo-(12Z)-octadecenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5262921", "l": "Defective IKBKG (NEMO) destabilizes the association of IKBKA:IKBKB:IKBKG (via TLR) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13110", "l": "2-acetamidofluorene + H2O + NAD(+) => H(+) + N-hydroxy-2-acetamidofluorene + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645598", "l": "RRAGC,D hydrolyzes GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202307", "l": "Change of PKC theta conformation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050201", "l": "fucokinase activity", "d": ["Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928645", "l": "EPHB:NMDAR binds TIAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27385", "l": "H2O + maleamate = maleate + NH4(+)", "d": []}, {"i": "EC:3.5.1.107", "l": "\"maleamate amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71775", "l": "acetoacetate(out) + H(+)(out) = acetoacetate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19244", "l": "ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74699", "l": "(5R)-hydroxy-beta-trans-bergamotene + O2 = (3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322427", "l": "Beta-catenin recruits CBP/p300 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37851", "l": "13-deoxydaunorubicin + H(+) + NADPH + O2 = 13-dihydrodaunorubicin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203977", "l": "SAR1 Activation And Membrane Binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0004222", "l": "metalloendopeptidase activity", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033778", "l": "7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity", "d": ["Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + H+ + NADPH + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070699", "l": "type II activin receptor binding", "d": ["Binding to a type II activin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70172", "l": "H(+)(in) + pemetrexed(in) => H(+)(out) + pemetrexed(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40894", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22085", "l": "(S)-2,3-diaminopropanoate + H(+) + H2O => 2 NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74224", "l": "H2O + L-seryl-tRNA(Ala) => L-serine + tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53441", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.432445482536949", "identifiers": [{"i": "GO:0031406", "l": "carboxylic acid binding", "d": ["Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21278", "l": "D-xylulose + H(+) + NADPH => D-arabinitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39397", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59012", "l": "cycloartenol + S-adenosyl-L-methionine = 24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46197", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40167", "l": "hexadecanoyl-CoA + O2 = (2E)-hexadecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48047", "l": "ganglioside GM1 (d18:1(4E)/18:0) + H2O <=> D-galactose + ganglioside GM2 (d18:1(4E)/18:0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23847", "l": "ATP + sedoheptulose <=> ADP + D-sedoheptulose 7-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45435", "l": "H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17880", "l": "a catechol + S-adenosyl-L-methionine <=> a guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44577", "l": "4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) => 2-all-trans-nonaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031707", "l": "endothelin A receptor binding", "d": ["Binding to an endothelin A receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102475", "l": "2-hydroxyeriodictyol 6C-glucoside dehydratase activity", "d": ["Catalysis of the reaction: 6C-beta-D-glucosyl-2-hydroxyeriodictyol <=> isoorientin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42591", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22860", "l": "ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate", "d": []}, {"i": "EC:2.7.7.18", "l": "\"nicotinate-nucleotide adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004034", "l": "aldose 1-epimerase activity", "d": ["Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391868", "l": "Dephosphorylation of NCAM1 bound pFyn (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23176", "l": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.1", "l": "\"acetate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201634", "l": "Caspase-mediated cleavage of FADK 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17568", "l": "myo-inositol + S-adenosyl-L-methionine <=> 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70461", "l": "a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35507", "l": "30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944232", "l": "Association of procollagen type XII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-383190", "l": "HCO3- transport through ion channel (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15565", "l": "an N-acyl-L-amino acid + H2O = a carboxylate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52784", "l": "2-sulfenohercynine + AH2 + H(+) = A + ergothioneine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247847", "l": "WLS is endocytosed to the early endosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654510", "l": "FGFRL1 binds SPRED1/2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12525", "l": "L-pipecolate + NADP(+) => Delta(1)-piperideine-2-carboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41470", "l": "H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase] => ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032566", "l": "dGDP binding", "d": ["Binding to dGDP, deoxyguanosine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68523", "l": "(2E,6E)-farnesyl diphosphate <=> beta-acoradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74734", "l": "Re-integration of insulin receptor into plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58765", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25363", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) = H(+) + momilactone A + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43090", "l": "5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine => 5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "56.126316727315697", "identifiers": [{"i": "GO:0016301", "l": "kinase activity", "d": ["Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080043", "l": "quercetin 3-O-glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3-hydroxy group of a quercetin molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602484", "l": "Activation of proMMP11 by FURIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047478", "l": "aspartate-ammonia ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: L-aspartate + ATP + NH4 = L-asparagine + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33812", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine => 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983424", "l": "Budding of COPII coated vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.325", "l": "\"sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75856", "l": "Abortive Initiation Before Second Transition (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33841", "l": "7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate => (2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44715", "l": "a 1,2-diacylglycerol + H2O <=> a 1-acylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9728150", "l": "SLC5A2 binds gliflozins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32919", "l": "H2O + methyl (indol-3-yl)acetate = (indol-3-yl)acetate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41385", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49519", "l": "2-oxoglutarate + an N(1)-methyladenosine in mRNA + O2 <=> an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134914", "l": "Beta-catenin migrates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45301", "l": "an N-(acyl)-sphingosylphosphocholine + H2O => an N-acyl-sphingoid base + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5225649", "l": "RBBP7 binds histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72112", "l": "L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out) => L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32564", "l": "(2E)-geranyl diphosphate => alpha-terpinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004530", "l": "deoxyribonuclease I activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4411373", "l": "NLK translocates to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875661", "l": "GGA3 associates with activated MET receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36523", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102474", "l": "eriodictyol dibenzoylmethane tautomer 6C-glucosyltransferase activity", "d": ["Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose <=> 6C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61933", "l": "(S)-miconazole(in) + ATP + H2O => (S)-miconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018453", "l": "2-hydroxytetrahydrofuran dehydrogenase activity", "d": ["Catalysis of the reaction: 2-hydroxytetrahydrofuran = 2 H+ + 2 e- + butyrolactone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11924", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = globoside Gb3Cer (d18:1(4E)) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.228", "l": "\"lactosylceramide 4-alpha-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30591", "l": "H2O + O2 + tyramine = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.114", "l": "\"3-dehydro-bile acid Delta(4,6)-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004962", "l": "endothelin receptor activity", "d": ["Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750666", "l": "ALB binds ST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15211", "l": "2-hydroxy-3-oxosuccinate + H(+) + NADH => (2R,3R)-tartrate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112434", "l": "Formation of DSIF complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31226", "l": "cis-beta-D-glucosyl-2-hydroxycinnamate + H2O <=> beta-D-glucose + cis-2-coumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046820", "l": "4-amino-4-deoxychorismate synthase activity", "d": ["Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58216", "l": "A + dihydroserpentine = AH2 + serpentine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.57", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15931", "l": "CO2 + N-(hydroxymethyl)urea + 2 NH4(+) => 2 H(+) + 2 H2O + methylenediurea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37771", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61063", "l": "beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose <=> a neolactoside nLc4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22832", "l": "H2O + N-formimidoyl-L-glutamate = N-formyl-L-glutamate + NH4(+)", "d": []}, {"i": "EC:3.5.3.13", "l": "\"formimidoylglutamate deiminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691154", "l": "HFE binds TFRC dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433395", "l": "Dimerization of sSCF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20243", "l": "N-methylnicotinate + S-adenosyl-L-homocysteine => nicotinate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53513", "l": "(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10014", "l": "6-hydroxypseudooxynicotine + H2O2 => (R)-6-hydroxynicotine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061501", "l": "2',3'-cyclic GMP-AMP synthase activity", "d": ["Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5') (cyclic 2',3' GAMP)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65106", "l": "aculene B + holo-[peptidyl-carrier protein] => aculene D + L-prolyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41146", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060001", "l": "minus-end directed microfilament motor activity", "d": ["A motor activity that generates movement along a microfilament towards the minus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64955", "l": "dCDP + H2O <=> dCMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59370", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+) => 1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209910", "l": "Iodide is taken up by thyroid epithelial cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65048", "l": "4-acetoxybenzyl alcohol + NAD(+) = 4-acetoxybenzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44003", "l": "2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 <=> 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191303", "l": "FDPS dimer transfers IPPP to GPP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13432", "l": "2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) <=> 4-CDP-2-C-methyl-D-erythritol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65566", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine => (9Z)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56832", "l": "2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) = 2,3,6-trichlorohydroquinone + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21760", "l": "(3S)-3-hydroxybutanoyl-CoA = (3R)-3-hydroxybutanoyl-CoA", "d": []}, {"i": "EC:5.1.2.3", "l": "\"3-hydroxybutyryl-CoA epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46030", "l": "(2R)-hydroxytetradecanoate + H2O => H2O2 + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55286", "l": "all-trans-retinyl tetradecanoate + CoA => all-trans-retinol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19418", "l": "[phosphate](n) + a dolichyl diphosphate => [phosphate](n+1) + a dolichyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53582", "l": "20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52514", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+) => a quinone + trans-4-hydroxy-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341048", "l": "SUMOylation of RXRA with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66510", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46834", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21511", "l": "all-trans-retinyl hexadecanoate + H2O <=> H(+) + hexadecanoate + retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140815", "l": "NAD+-protein-histidine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-histidyl-[protein] + NAD+ = H+ + Nt-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide."]}, {"i": "RHEA:72071", "l": "L-histidyl-[protein] + NAD(+) = H(+) + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209172", "l": "Phosphorylation of CI by SGG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13877", "l": "a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678327", "l": "MIOX oxidises Ins to GlcA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42307", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56425", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.181", "l": "\"galactan endo-beta-1,3-galactanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69007", "l": "3-amino-2-hydroxy-4-methoxybenzoate + ATP + nitrite <=> AMP + cremeomycin + diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52593", "l": "deoxycholoyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35092", "l": "anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine => 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.8", "l": "\"3'-phosphate/5'-hydroxy nucleic acid ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805470", "l": "AMPK phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912355", "l": "Glycosylation of Pre-NOTCH by FRINGE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15230", "l": "alpha-D-mannose 1-phosphate + GTP + H(+) => diphosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63473", "l": "all-trans-hexaprenol + ATP => ADP + all-trans-hexaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16353", "l": "2-oxoglutarate + taurine = L-glutamate + sulfoacetaldehyde", "d": []}, {"i": "EC:2.6.1.55", "l": "\"taurine--2-oxoglutarate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45253", "l": "tetradecanoate(out) => tetradecanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451283", "l": "kainate receptor binds glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48565", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O => D-ribose 5-phosphate + trans-zeatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25825", "l": "H2O + O2 + spermine => H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445705", "l": "Release Of ADP From Myosin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72097", "l": "(S)-carnitine(in) + Na(+)(in) => (S)-carnitine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701507", "l": "PTPN6 dephosphorylates JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392530", "l": "p-S400-Cot phosphorylates NIK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57503", "l": "3-hydroxybutane-1,2,3-tricarboxylate <=> 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102800", "l": "caffeoyl-CoA:pelargonidin-3,5-diglucoside-6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: anthocyanidin 3,5-di-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin 3-O-(6-O-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047640", "l": "aldose 1-dehydrogenase activity", "d": ["Catalysis of the reaction: D-aldose + NAD+ = D-aldonolactone + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844619", "l": "AIM2 binds dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299359", "l": "Activation of TALK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73509", "l": "7-hydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 7,8-dihydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222412", "l": "lpdC dimer reactivates dlaT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012556", "l": "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17616", "l": "NAD(+) + scyllo-inositol <=> H(+) + NADH + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629154", "l": "NEIL1 recognizes and binds thymine glycol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42699", "l": "H2O + hercynylselenocysteine <=> NH4(+) + pyruvate + selnoneine thione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036193", "l": "2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity", "d": ["Catalysis of the reaction: 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)H + H+ + O2 = 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085992", "l": "SUMOylation of DAXX with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67250", "l": "(E)-4-hydroxynon-2-enoate + 2 H(+) + NADH => (E)-4-hydroxynon-2-enal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.41", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174444", "l": "Formation of C-strand Okazaki fragments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23776", "l": "ATP + L-aspartate = 4-phospho-L-aspartate + ADP", "d": []}, {"i": "EC:2.7.2.4", "l": "\"aspartate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35152", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) => (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12146", "l": "cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP => cyanidin 3-O-rutinoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17291", "l": "beta-D-fructose 6-phosphate + phosphate => beta-D-fructose 2,6-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031610", "l": "p-S133 CREB1, MEF2D and SRF  bind the ARC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625416", "l": "Anterograde IFT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31297", "l": "2-oxopent-4-enoate => (2E)-2-hydroxypenta-2,4-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847968", "l": "PTEN binds FRK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36520", "l": "H(+) + hexacosanoyl-CoA + malonyl-CoA => 3-oxooctacosanyol-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879331", "l": "glucose-6-phosphate is converted to inositol-1-phosphate (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41760", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E)) = CMP + ganglioside GD3 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31851", "l": "(S)-2,3-epoxysqualene = parkeol", "d": []}, {"i": "EC:5.4.99.47", "l": "\"parkeol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417825", "l": "P2Y11 receptor can bind to ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34605", "l": "CoA + H(+) + N-acyl-15-methylhexadecasphinganine => 15-methylhexadecasphinganine + a fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693608", "l": "Initial resection of double-strand break ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52719", "l": "a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH <=> a long-chain primary fatty alcohol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55722", "l": "17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate => 17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694441", "l": "3CLp cleaves pp1a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66416", "l": "ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O = ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.59", "l": "\"tryptophan 6-halogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052894", "l": "norspermine:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: norspermine + oxygen + H2O = norspermidine + 3-aminopropanal + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "ic": "55.970323817434654", "identifiers": [{"i": "GO:0016705", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51687", "l": "(2E,6E)-farnesyl phosphate + CTP <=> (2E,6E)-farnesyl diphosphate + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664867", "l": "NBR1 binds MAP1LC3B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27492", "l": "2 D-sedoheptulose 7-phosphate <=> D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39153", "l": "(3R)-hydroxyoctadecanoyl-CoA + NADP(+) => 3-oxooctadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654603", "l": "Activated FGFR2 binds FRS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0045183", "l": "translation factor activity, non-nucleic acid binding", "d": ["A translation regulator activity that does not involve binding to nucleic acids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60925", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 => CO2 + formaldehyde + L-lysyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420117", "l": "VEGFR2 autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44464", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38304", "l": "2-amino-2-deoxy-D-gluconate 6-phosphate => 2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637651", "l": "esxA translocates from Mtb cytosol to the host's ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804425", "l": "TP53 binds POU4F2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45421", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine => a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15273", "l": "2-oxoglutarate + L-dopa = 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate", "d": []}, {"i": "EC:2.6.1.49", "l": "\"dihydroxyphenylalanine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59910", "l": "2 H(+) + hexanoate + NADPH => H2O + hexanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16760", "l": "NADP(+) + trypanothione <=> H(+) + NADPH + trypanothione disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73276", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine => 4',7,8-trihydroxy-3'-methoxyflavone-7-olate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65366", "l": "a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30876", "l": "2-oxoglutarate + D-lysine => 6-amino-2-oxohexanoate + D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19112", "l": "1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose <=> 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54014", "l": "(8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38627", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49155", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine <=> dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12838", "l": "ATP + choline => ADP + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9761027", "l": "ZEB2 binds SP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63660", "l": "(8S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein] = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+)", "d": []}, {"i": "EC:2.6.1.121", "l": "\"8-amino-7-oxononanoate carboxylating dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69242", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+) => glucoraphanin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62404", "l": "(R)-2-hydroxyhexadecanoate + O2 = CO2 + H2O + pentadecanoate", "d": []}, {"i": "EC:1.14.18.12", "l": "\"2-hydroxy fatty acid dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37612", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421453", "l": "Mitochondrial uptake and processing of ALAS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9032798", "l": "DOCK3 activates RAC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40354", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP <=> 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25744", "l": "H(+) + N,N-dihydroxy-L-pentahomomethionine => (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48524", "l": "ganglioside GP1c + H2O = ganglioside GQ1c + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60849", "l": "a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0036238", "l": "gallate dioxygenase activity", "d": ["Catalysis of the reaction: gallate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74742", "l": "Phosphorylation of SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72876", "l": "anthocyanin A7 + malonyl-CoA => anthocyanin A9 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17367", "l": "ADP + H(+) + Mn(2+)(in) + phosphate => ATP + H2O + Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183122", "l": "Factor D cleaves C3b-bound Factor B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27891", "l": "3'-UMP + H2O => phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47864", "l": "1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350058", "l": "Formation of CSL NCOR corepressor complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57375", "l": "H2O + NADPH <=> (6S)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.10", "l": "\"pyrimidine-5'-nucleotide nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11151", "l": "4 Fe(2+) + 4 H(+) + O2 <=> 4 Fe(3+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-452122", "l": "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43338", "l": "CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out) => H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5159250", "l": "ATF7IP binds SETDB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69700", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + H2O => beta-D-glucose + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74156", "l": "H2O + oxidized 2[4Fe-4S]-[ferredoxin] + sarcosine => formaldehyde + glycine + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49624", "l": "ATP + erythritol = ADP + D-erythritol 1-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.215", "l": "\"erythritol kinase (D-erythritol 1-phosphate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610442", "l": "Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733973", "l": "Bile salts bind FABP6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13790", "l": "[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65325", "l": "acetyl-CoA + chrodrimanin A => chrodrimanin B + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875816", "l": "STAT3 binds activated MET receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59495", "l": "(2E)-geranyl diphosphate + L-tryptophyl-[protein] <=> (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031850", "l": "delta-type opioid receptor binding", "d": ["Binding to a delta-type opioid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31220", "l": "5-hydroxykynurenamine + CO2 => 5-hydroxy-L-kynurenine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34360", "l": "a 1,2-diacylglycerol + H2O => a 2-acylglycerol + a carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16834", "l": "2 glutathione + H2O2 => glutathione disulfide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52171", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132133", "l": "C5b:C6:C7 inserts into the target cell membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421835", "l": "trans-Golgi Network Vesicle Scission (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48324", "l": "ganglioside GD1b + GDP-beta-L-fucose = ganglioside Fuc-GD1b + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72647", "l": "Cap-bound mRNA is activated by helicases  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977301", "l": "Histidine is decarboxylated to histamine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15483", "l": "(6S)-5,6,7,8-tetrahydrofolate + L-serine => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-708349", "l": "Activated NOD2 oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.10", "l": "\"homocysteine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55467", "l": "11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56830", "l": "2,3,5,6-tetrachlorohydroquinone + 2 glutathione => 2,3,6-trichlorohydroquinone + chloride + glutathione disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14629", "l": "ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate", "d": []}, {"i": "EC:2.7.2.8", "l": "\"acetylglutamate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75922", "l": "H2O + NADP(+) + serinol <=> dihydroxyacetone + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68724", "l": "26-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 26-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23550", "l": "H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(966) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15604", "l": "(E)-cinnamoyl-CoA + (R)-3-phenyllactate <=> (E)-cinnamate + (R)-3-phenyllactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19462", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449077", "l": "Interleukin-16 is secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210274", "l": "SIRP beta binds TYROBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798044", "l": "BTG2 binds CCR4-NOT complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36598", "l": "hydrogen sulfide + NADP(+) <=> NADPH + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55740", "l": "H2O + oleuropein = D-glucose + oleuropein aglycone", "d": []}, {"i": "EC:3.2.1.206", "l": "\"oleuropein beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75520", "l": "FMNH2 + N-acetyl-S-benzyl-L-cysteine + O2 => (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55718", "l": "(9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+) => (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22084", "l": "(S)-2,3-diaminopropanoate + H(+) + H2O = 2 NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70982", "l": "Fumarate + H2O <=> (S)-Malate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426032", "l": "DAG is metabolized by DAGL to 2-AG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.7.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39588", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73977", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43280", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68416", "l": "cis-(homo)2aconitate + H2O = (2R,3S)-iso(homo)2citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645535", "l": "ALPK1 phosphorylates TIFA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110437", "l": "DILP binds to Drosophila insulin receptor (DINR) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5649856", "l": "Oxidative damage to the AP site (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69322", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose => glucoerucin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48131", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (2E,6E)-farnesyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63871", "l": "(9Z)-octadecenoate + O2 <=> (2R,9Z)-2-hydroperoxyoctadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10209", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) => H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682012", "l": "ATG5:ATG12 binds ATG16L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27699", "l": "GDP-beta-L-galactose + phosphate => beta-L-galactose 1-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672969", "l": "Phosphorylation of RAF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60704", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44203", "l": "12-methyloctadecanoate + ATP + CoA <=> 12-methyloctadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25991", "l": "(5R)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28966", "l": "H(+)(out) + L-proline(out) <=> H(+)(in) + L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24237", "l": "2 Fe(III)-[cytochrome c] + H2O + trimethylamine => 2 Fe(II)-[cytochrome c] + 3 H(+) + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20262", "l": "3,5,7-trioxododecanoyl-CoA => CO2 + CoA + olivetol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42413", "l": "(2R)-2,3-bisphosphoglycerate + ATP + H(+) => ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1470010", "l": "Dimerization of STATs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59000", "l": "H2O + O2 + propanal = H(+) + H2O2 + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12777", "l": "2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + chemical entity", "d": []}, {"i": "EC:1.17.3.1", "l": "\"pteridine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20340", "l": "(R)-2-O-sulfolactate + H2O <=> (R)-lactate + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22864", "l": "L-lysine = D-lysine", "d": []}, {"i": "EC:5.1.1.5", "l": "\"lysine racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693761", "l": "FA2H hydroxylates CERA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30514", "l": "2-demethylmenaquinone-8 + H(+) + NADPH <=> 2-demethylmenaquinol-8 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33150", "l": "ATP + daunorubicin(in) + H2O <=> ADP + daunorubicin(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12036", "l": "(S)-3-(imidazol-5-yl)lactate + NAD(+) = 3-(imidazol-5-yl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10320", "l": "trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O", "d": []}, {"i": "EC:4.2.1.77", "l": "\"trans-L-3-hydroxyproline dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140806", "l": "SERPINC1 binds SERPINC1 activators (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45551", "l": "phycourobilin-L-cysteinyl(84)-[R-phycocyanin alpha-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[R-phycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755354", "l": "8 forms a homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32108", "l": "3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine => H(+) + pterostilbene + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72171", "l": "2 Na(+)(out) + taurohyocholate(out) = 2 Na(+)(in) + taurohyocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801195", "l": "STEAP3 binds BNIP3L (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70794", "l": "H(+)(in) + L-ornithine(out) <=> H(+)(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43741", "l": "ATP + CoA + hexanoate => AMP + diphosphate + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29042", "l": "ATP + H2O + L-aspartate(out) <=> ADP + H(+) + L-aspartate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18559", "l": "1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA => 1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947499", "l": "Exchange of oxygen with sulfur in MoCo (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382058", "l": "Nck binds to the active PDGF receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008413", "l": "8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity", "d": ["Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156682", "l": "PLK1 phosphorylates NUDC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59309", "l": "D-galactono-1,5-lactone + H2O => D-galactonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47565", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GA2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54993", "l": "3 A + FMN + H2O + L-glutamate + O2 => 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48694", "l": "H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => 1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.3.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32310", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> H2O + leukotriene A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51363", "l": "H2O + N-(9Z-octadecenoyl)-L-leucine <=> (9Z)-octadecenoate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38208", "l": "19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34587", "l": "2-oxoglutarate + O2 + pentalenolactone E = CO2 + pentalenolactone F + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68998", "l": "CO2 + gibberellin A4 + succinate => 2-oxoglutarate + gibberellin A9 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43612", "l": "S-adenosyl-L-methionine + uridine(341) in tmRNA = 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18137", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) = 5alpha-pregnane-3,20-dione + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.278", "l": "\"3beta-hydroxy-5alpha-steroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51293", "l": "a quinone + H2O + L-methionyl-[protein] => a quinol + L-methionyl-(S)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23559", "l": "D-alanine + L-glutamine <=> gamma-L-glutamyl-D-alanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36601", "l": "NADH + sulfur => hydrogen sulfide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380782", "l": "STAT binds to the active receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20354", "l": "A + chloride + H(+) + trichloroethene => AH2 + tetrachloroethene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021954", "l": "MECP2 binds OPRK1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31122", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA <=> (2E)-2-methylbut-2-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53631", "l": "(2E,6E)-farnesyl diphosphate <=> (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862771", "l": "PLA2G2A binds bacterial phospholipids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28610", "l": "H2O + XTP = diphosphate + H(+) + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71907", "l": "GDP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0019843", "l": "rRNA binding", "d": ["Binding to a ribosomal RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11097", "l": "NADP(+) + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76386", "l": "CYP1A2 S-demethylates 6MMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43277", "l": "ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GalNAc-GD1a + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035990", "l": "Defective HLCS does not biotinylate 6x(PCCA:PCCB) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66599", "l": "O2 + 2 tyramine <=> 2 dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705726", "l": "SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26432", "l": "diphosphate + phyllocladan-16alpha-ol => (+)-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29756", "l": "(R)-lipoate(in) => (R)-lipoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102264", "l": "tRNA-dihydrouridine20 synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil20 in tRNA + NAD(P) = H+ + a uracil20 in tRNA + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12654", "l": "(S)-malate + NAD(+) => CO2 + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707516", "l": "FeHM dissociates from MetHb (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66365", "l": "(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O => 6-methyl-3,7-dioxodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167153", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55881", "l": "apo-[aequorin]--coelenterazine + O2 => [aequorin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42822", "l": "H2O + 2 NADP(+) + tetracenomycin C => 2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635845", "l": "GLI proteins bind CDC73 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693540", "l": "MRN activates ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66513", "l": "1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34098", "l": "carboxyspermidine + H(+) <=> CO2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036461", "l": "BLOC-2 complex binding", "d": ["Binding to a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682011", "l": "LC3 binds ATG7 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28642", "l": "(2Z,6E)-farnesyl diphosphate <=> (-)-gamma-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.509227218911647", "identifiers": [{"i": "GO:0016813", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2."]}, {"i": "EC:3.5.3.-", "l": "\"In linear amidines\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5444511", "l": "Formation of MSH2:MSH3 Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54748", "l": "ATP + CoA + firefly L-luciferin = AMP + diphosphate + L-firefly luciferyl-CoA", "d": []}, {"i": "EC:6.2.1.52", "l": "\"L-firefly luciferin--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20531", "l": "2-cis-(+)-abscisate + H(+) + H2O2 => 2-cis-(+)-abscisic aldehyde + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189467", "l": "Cytosolic COPRO3 translocates to mitochondrial intermembrane space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047474", "l": "long-chain fatty acid luciferin component ligase activity", "d": ["Catalysis of the reaction: protein + an acid + ATP = an acyl-protein thiolester + diphosphate + AMP. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0015391", "l": "nucleobase:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50591", "l": "13,14-dihydro-15-oxo-PGF2alpha + NADP(+) <=> 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46653", "l": "epitestosterone + H(+) + NADPH => 5beta-dihydroepitestosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103045", "l": "methione N-acyltransferase activity", "d": ["Catalysis of the reaction: L-methionine + acetyl-CoA = N-acetyl-L-methionine + coenzyme A + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38600", "l": "NADP(+) + nicotinate => nicotinamide + nicotinate-adenine dinucleotide phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59097", "l": "monoglucosyl-enterobactin + UDP-alpha-D-glucose => diglucosyl-enterobactin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864569", "l": "WWOX binds TFAP2C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29183", "l": "menaquinol-8 + 2 O2 = 2 H(+) + menaquinone-8 + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647980", "l": "mature RAS proteins translocate to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804266", "l": "CHEK2 phosphorylates TTC5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56622", "l": "2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+) => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019797", "l": "procollagen-proline 3-dioxygenase activity", "d": ["Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421831", "l": "trans-Golgi Network Coat Assembly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30073", "l": "acetate + butanoyl-CoA => acetyl-CoA + butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34793", "l": "formate + H(+) + hydroxymethylphosphonate => 2-hydroxyethylphosphonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700190", "l": "ALK mutants bind SHC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74269", "l": "n H(+)(in) + spermidine(out) => n H(+)(out) + spermidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27895", "l": "3'-CMP + H2O => cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.-.-.-", "l": "\"Isomerases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663118", "l": "p-BMAL1:p-CLOCK,NPAS2 binds PER2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53738", "l": "a halide anion + catechol + CO2 + NAD(+) => a 2-halobenzoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097099", "l": "structural constituent of albumen", "d": ["The action of a molecule that contributes to the structural integrity of albumen (also called egg white). Albumen is the clear liquid contained within an egg and consists of water and proteins, among which are ovomucin and ovomucoid. It protects the egg yolk and provides additional nutrition for the growth of the embryo."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17003", "l": "proclavaminate + urea => amidinoproclavaminate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.186", "l": "\"glycogenin glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388468", "l": "AVP(20-28) binds AVPR1A,B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50706", "l": "H(+) + NADH + propanal => 1-propanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44510", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43444", "l": "1,2-ditetradecanoyl-sn-glycerol + ATP = 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.90", "l": "\"isoflavone 2'-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042897", "l": "polymyxin transmembrane transporter activity", "d": ["Enables the transfer of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74133", "l": "H(+) + malvidin 3-O-beta-D-galactoside + UDP => malvidin + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37155", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45828", "l": "(3R)-hydroxyhexanoyl-CoA + NAD(+) = 3-oxohexanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15310", "l": "(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] => biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73042", "l": "H(+)(out) + Ni(2+)(out) <=> H(+)(in) + Ni(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030976", "l": "thiamine pyrophosphate binding", "d": ["Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73220", "l": "L-xylopyranose(out) + 2 Na(+)(out) => L-xylopyranose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156930", "l": "GTP-binding activates eEF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45311", "l": "H(+) + NADPH + prostaglandin D2-ethanolamide <=> 11beta-prostaglandin F2-ethanolamide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11491", "l": "all-trans-retinol + an acyl-CoA <=> an all-trans-retinyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16084", "l": "(2R)-S-methyl-3-phospho-1-thioglycerate + H2O <=> (2R)-S-methyl-1-thioglycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13717", "l": "2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.267", "l": "\"1-deoxy-D-xylulose-5-phosphate reductoisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70471", "l": "2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in single-stranded DNA + H2O + O2 = a 2'-deoxycytidine in single-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24335", "l": "3alpha-hydroxy-3,5-dihydromonacolin L carboxylate <=> H2O + monacolin L carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046571", "l": "aspartate-2-keto-4-methylthiobutyrate transaminase activity", "d": ["Catalysis of the reaction: 2-keto-4-methylthiobutyrate + aspartate = methionine + oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0050545", "l": "sulfopyruvate decarboxylase activity", "d": ["Catalysis of the reaction: 3-sulfopyruvate + H+ = CO2 + sulfoacetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358789", "l": "Self-ubiquitination of RNF41 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20844", "l": "ATP + hydrogencarbonate + pyruvate = ADP + H(+) + oxaloacetate + phosphate", "d": []}, {"i": "EC:6.4.1.1", "l": "\"pyruvate carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21926", "l": "2,3-dioxo-L-gulonate + H(+) + NADH => 3-dehydro-L-gulonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696266", "l": "RND2 binds effectors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23935", "l": "an N-acyl-D-glucosamine 6-phosphate <=> an N-acyl-D-mannosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168136", "l": "NOTCH3 binds DLL4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45045", "l": "2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2 => 2 Fe(III)-[cytochrome c] + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35084", "l": "diacetylchitobiose-6'-phosphate + H2O => acetate + N'-monoacetylchitobiose-6'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13796", "l": "2-methyleneglutarate <=> 2-methylene-3-methylsuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35402", "l": "1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine <=> beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48854", "l": "13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218814", "l": "PAK2 autophorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23893", "l": "3-nitropropanoate + NADP(+) => 3-nitroacrylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35873", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3858489", "l": "ppDVL binds DAAM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030775", "l": "glucuronoxylan 4-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24848", "l": "3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O", "d": []}, {"i": "EC:4.2.1.118", "l": "\"3-dehydroshikimate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686430", "l": "MUS81 binds EME1, EME2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51238", "l": "GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate => GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350604", "l": "Agmatine + H2O <=> putrescine + urea (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12888", "l": "GDP-alpha-D-mannose + queuosine(34) in tRNA(Asp) <=> GDP + H(+) + O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905394", "l": "retromer complex binding", "d": ["Binding to a retromer complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19460", "l": "2-nitrophenol + 2 H(+) + 2 NADPH + O2 <=> catechol + H2O + 2 NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42270", "l": "4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA => 2-methylpropanoyl-CoA + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-435244", "l": "PECAM1 is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449200", "l": "Interaction of ABL1 with CDO complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60101", "l": "cyanidin + UDP-alpha-D-glucose => cyanidin 3-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59771", "l": "hexadecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] <=> CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71529", "l": "thymine(in) => thymine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754129", "l": "CDK6 inhibitors bind CDK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48515", "l": "ATP + H2O + phosphinate(out) <=> ADP + H(+) + phosphate + phosphinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211191", "l": "Association of DFF with alpha:beta importin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15090", "l": "(R)-lactate + A => AH2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74968", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + H(+) => a (3R)-3-isocyanyl-fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175177", "l": "Association of  XRCC4:DNA ligase IV complex with viral DNA ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953013", "l": "E2F7 binds E2F8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59951", "l": "H2O + prostaglandin F2alpha-CoA <=> CoA + H(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112435", "l": "Formation of Elongin BC complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610038", "l": "Defective GALT does not transfer UMP to Gal1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.31", "l": "\"mycolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948027", "l": "RNASEs bind bacterial phospholipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803719", "l": "TP53 binds ZNF385A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029468", "l": "Conversion of PA into DAG by PAP-1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31048", "l": "(S)-methylmalonate semialdehyde + CoA + NAD(+) => CO2 + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73424", "l": "L-asparagine(out) => L-asparagine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187698", "l": "RIT/RIN-GTP binds B-RAF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139893", "l": "Granzyme-B activates BID by cleavage (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41796", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004375", "l": "glycine dehydrogenase (decarboxylating) activity", "d": ["Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29449", "l": "glycolate(out) => glycolate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37085", "l": "[sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46010", "l": "H(+) + NADH + pentanoyl-CoA => CoA + NAD(+) + pentanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21504", "l": "acetoin + aldehydo-D-ribose 5-phosphate = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde", "d": []}, {"i": "EC:2.2.1.4", "l": "\"acetoin--ribose-5-phosphate transaldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12457", "l": "CTP + D-ribitol 5-phosphate + H(+) => CDP-L-ribitol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57926", "l": "diphosphate + premutilin => H2O + mutildienyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2545196", "l": "FN1 dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31764", "l": "a 2-oxocarboxylate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56041", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39218", "l": "(2E)-hexacosenoyl-CoA + H(+) + NADPH <=> hexacosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16117", "l": "acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.16", "l": "\"acetoacetate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48046", "l": "D-galactose + ganglioside GM2 (d18:1(4E)/18:0) => ganglioside GM1 (d18:1(4E)/18:0) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-83788", "l": "Binding of TFIIIC to Type 2 promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951499", "l": "Loading of antigenic peptides on to class I MHC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13844", "l": "Fe(II)2-[transferrin] + H(+) + NAD(+) <=> Fe(III)2-[transferrin] + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37905", "l": "H(+) + S-adenosyl-L-homocysteine + tryprostatin A => 6-hydroxytryprostatin B + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731034", "l": "SARS-CoV-1 3a tetramer binds to CAV1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-844438", "l": "NLRP1 oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112379", "l": "Recruitment of elongation factors to form elongation complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29566", "l": "ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45033", "l": "4 Fe(III)-[cytochrome c] + H2O + hydroxylamine => 4 Fe(II)-[cytochrome c] + 5 H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018597", "l": "ammonia monooxygenase activity", "d": ["Catalysis of the oxidation of alkanes (up to C8) to alcohols and alkenes (up to C5) to epoxides and alcohols in the presence of ammonium ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48048", "l": "ganglioside GM1 (d18:1(4E)) + H2O = D-galactose + ganglioside GM2 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75992", "l": "a dicarboxylate(in) + N-benzoylglycine(out) => a dicarboxylate(out) + N-benzoylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1253343", "l": "WWOX binds ERBB4s80 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31606", "l": "(Z)-3-ureidoacrylate + H2O <=> (Z)-3-aminoacrylate + carbamate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46960", "l": "butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.1.109", "l": "\"butanoyl-CoA dehydrogenase complex (NAD(+), ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43751", "l": "ATP + CoA + hexacosanoate <=> AMP + diphosphate + hexacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66606", "l": "a 2'-deoxyuridine in double-stranded DNA + NH4(+) => a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654571", "l": "Activated FGFR1 binds FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75407", "l": "2-dehydro-D-glucose = cortalcerone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42840", "l": "acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH = 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)", "d": []}, {"i": "EC:2.3.1.237", "l": "\"neocarzinostatin naphthoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199425", "l": "PHLPP dephosphorylates S473 in AKT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74718", "l": "Internalisation of the insulin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-383190", "l": "HCO3- transport through ion channel (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018794", "l": "RHOV binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042945", "l": "D-serine transmembrane transporter activity", "d": ["Enables the transfer of D-serine from one side of a membrane to the other. D-serine is the D-enantiomer of 2-amino-3-hydroxypropanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10719", "l": "D-glucose 6-phosphate <=> 1D-myo-inositol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75825", "l": "5-oxo-(6E,8Z)-octadecadienoate + H(+) + 2 H2O + oxidized [NADH--hemoprotein reductase] => (5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11973", "l": "4 Fe(2+) + 6 H2O + O2 => 12 H(+) + 4 iron(III) oxide-hydroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55383", "l": "a 3alpha-hydroxy bile acid CoA + NAD(+) <=> a 3-oxo bile acid CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047130", "l": "saccharopine dehydrogenase (NADP+, L-lysine-forming) activity", "d": ["Catalysis of the reaction: L-saccharopine + H2O + NADP+ = 2-oxoglutarate + L-lysine + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004523", "l": "RNA-DNA hybrid ribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11793", "l": "H(+) + NADH + O2 + propene => 1,2-epoxypropane + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33245", "l": "(E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69620", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72571", "l": "dehydroepiandrosterone 3-sulfate(in) + pentanoate(out) = dehydroepiandrosterone 3-sulfate(out) + pentanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082391", "l": "Trimerization of HSF1 in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35373", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate => 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63575", "l": "H2O + neurotensin-(1-8) <=> L-arginine + neurotensin-(1-7)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71496", "l": "6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) => 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51737", "l": "L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63020", "l": "(9Z,12Z)-octadecadienamide + H2O = (9Z,12Z)-octadecadienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73931", "l": "chloride + FADH2 + griseophenone C + O2 = FAD + griseophenone B + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22573", "l": "A + H2O + N-methyl-L-glutamate => AH2 + formaldehyde + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13007", "l": "H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine => (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109857", "l": "MAP2K1 binds MAPK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65773", "l": "2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16381", "l": "L-arabinitol + NAD(+) = H(+) + L-xylulose + NADH", "d": []}, {"i": "EC:1.1.1.12", "l": "\"L-arabinitol 4-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855047", "l": "Hydrolysis of internal thioester in C4b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42941", "l": "cytidine(34) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15534", "l": "(2R)-3-sulfolactate + NAD(+) => 3-sulfopyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40731", "l": "(20S)-ginsenoside Rg3 + 2 H2O = (20S)-protopanaxadiol + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5620975", "l": "MLKL binds PIPs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45306", "l": "1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59420", "l": "H2O + methylamine + O2 = formaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25421", "l": "3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O => 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030108", "l": "HLA-A specific activating MHC class I receptor activity", "d": ["Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48858", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791109", "l": "GADD45A binds PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46784", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64737", "l": "4-hydroxynonanal + NADP(+) => (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032395", "l": "MHC class II receptor activity", "d": ["Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008939", "l": "nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H+ + nicotinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614614", "l": "Cysteine is degraded to serine and H2S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57361", "l": "H2O + NADH => (6R)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19479", "l": "3,4-dihydroxybenzoate + H2O + NADP(+) => 4-hydroxybenzoate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50209", "l": "cortisol + NAD(+) => cortisone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68914", "l": "DNA polymerase alpha:primase binds at the origin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45299", "l": "a sphingosylphosphocholine + H2O <=> a sphingoid base + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72664", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-phenylalanyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16678", "l": "fluoroacetaldehyde + H2O + NAD(+) => fluoroacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54042", "l": "(3E,7E)-dolathalia-3,7,11-triene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017005", "l": "3'-tyrosyl-DNA phosphodiesterase activity", "d": ["Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11060", "l": "ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)", "d": []}, {"i": "EC:6.1.1.5", "l": "\"isoleucine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983259", "l": "Kinesins move along microtubules consuming ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63526", "l": "3-propylcatechol + H2O + NAD(+) => 2-propylphenol + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13040", "l": "ATP + H(+) + H2O <=> ITP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948623", "l": "miR-20 microRNAs bind CNOT6L mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25897", "l": "H(+) + malonate => acetate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31155", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) = (4S)-4-hydroxy-L-glutamate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867344", "l": "OMA1 hydrolyses OPA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008043", "l": "MAPK8 phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58121", "l": "ATP + L-seryl-[protein] => 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192841", "l": "Viral Protein Synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31854", "l": "(S)-2,3-epoxysqualene <=> parkeol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52019", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA <=> 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427394", "l": "Cleavage of intergenic spacer RNA to yield fragments of 150-300 nucleotides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689630", "l": "BAP1 binds BAP1-interacting complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71853", "l": "glycocholate(in) => glycocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12516", "l": "(2E,6E)-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate", "d": []}, {"i": "EC:4.2.3.23", "l": "\"germacrene-A synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51488", "l": "archaetidylserine + H(+) = archaetidylethanolamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60933", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35919", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose = H(+) + kanamycin D + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14802", "l": "(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69436", "l": "7-oxopregnenolone + H(+) + NADPH = 7beta-hydroxypregnenolone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928656", "l": "gamma-secretase cleaves EPHB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400228", "l": "BMAL1 binds CLOCK,NPAS2 forming BMAL1:CLOCK,NPAS2 heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52130", "l": "a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+) => a 5'-end adenosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57096", "l": "AH2 + S-methyl-1-thio-D-xylulose 5-phosphate = 1-deoxy-D-xylulose 5-phosphate + A + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35794", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin X + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679239", "l": "ULK complex translocates to the ER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2545253", "l": "Deacetylation of cohesin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74013", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B + H2O + NADP(+) => [(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005117", "l": "wishful thinking binding", "d": ["Binding to wishful thinking (Wit), a type II bone morphogenic protein receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0016040", "l": "glutamate synthase (NADH) activity", "d": ["Catalysis of the reaction: 2 L-glutamate + NAD+ = 2-oxoglutarate + L-glutamine + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862300", "l": "LYZ binds bacterial peptidoglycan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72287", "l": "2,2-dimethylsuccinate(out) + 3 Na(+)(out) = 2,2-dimethylsuccinate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23324", "l": "2'-phospho-[ligated tRNA] + NAD(+) = ADP-alpha-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide", "d": []}, {"i": "EC:2.7.1.160", "l": "\"2'-phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15039", "l": "H(+) + N-methylputrescine + S-adenosyl-L-homocysteine => putrescine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034322", "l": "alcohol O-decanoyltransferase activity", "d": ["Catalysis of the reaction: decanoyl-CoA + an alcohol = CoA + a decyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67181", "l": "ATP + glycine + L-glutamyl-[protein] => ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65051", "l": "4-acetoxybenzyl alcohol + NAD(+) <=> 4-acetoxybenzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28133", "l": "baicalin + H2O <=> baicalein + D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-919404", "l": "Phosphorylated STAT5 is released (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21488", "l": "dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O = beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0005186", "l": "pheromone activity", "d": ["The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40105", "l": "CoA + H(+) + propanoate => H2O + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549322", "l": "OCT1 transports organic cations out of hepatic cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59419", "l": "H2O + O2 + tryptamine <=> H2O2 + indole-3-acetaldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163090", "l": "Elongation Of The Telomeric Chromosome End (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209057", "l": "Activated PLL kinase is autophosphorylated in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59167", "l": "ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] <=> AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67731", "l": "DNA(n) + dZTP <=> diphosphate + DNA(n)-Z", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381496", "l": "Formation of the IGF:IGFBP3:ALS complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004352", "l": "glutamate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21244", "l": "an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine = an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11007", "l": "2 H(+) + NADH + O2 + salicylate <=> catechol + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49189", "l": "a bacteriochlorophyllide d => a 3-vinylbacteriochlorophyllide d + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75637", "l": "10-hydroperoxy-(8E)-octadecenoate => (9Z)-octadecenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625416", "l": "Anterograde IFT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28762", "l": "beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose <=> alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48969", "l": "[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 => [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705584", "l": "HMGCR dimer binds statins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070095", "l": "fructose-6-phosphate binding", "d": ["Binding to fructose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668545", "l": "NIK autophosphorylates on T559 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59787", "l": "H2O + NADP(+) + pseudopaline <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44699", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O <=> a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16548", "l": "formyl-CoA + oxalate <=> formate + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14365", "l": "2 H(+) + H2O + N-carbamoyl-L-aspartate = CO2 + L-aspartate + NH4(+)", "d": []}, {"i": "EC:3.5.1.7", "l": "\"ureidosuccinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75751", "l": "(9Z)-octadecenoate + H2O = 10-hydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33657", "l": "(9Z)-octadecenoate(in) => (9Z)-octadecenoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949399", "l": "CAR translocates from the cytosol to the mitochondrial intermembrane space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48104", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482939", "l": "CDP-DAG is converted to PGP by PGS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30728", "l": "dATP + pyruvate => dADP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19151", "l": "H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide => L-arginyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52860", "l": "a short-chain fatty acid + ATP + CoA = a short-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12490", "l": "2-dehydro-3-deoxy-D-gluconate + NH4(+) => 2-amino-2-deoxy-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612219", "l": "ERBB4s80 binds to SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47550", "l": "3-oxochola-4,6-dien-24-oate + H2O => 7alpha-hydroxy-3-oxochol-4-en-24-oate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36889", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660694", "l": "Variant SLC6A20 does not cotransport L-Pro, Na+ from extracellulare region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31215", "l": "(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) = (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141159", "l": "TNF-mediated dimerization of procaspase-8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160935", "l": "SMURF1 ubiquitinates RHOA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20358", "l": "3-phenylpropanoate + H(+) + NADH + O2 => 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023980", "l": "18(S)-RvE1, E2 and E3 translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796368", "l": "RIPK1 binds STUB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40726", "l": "(9E)-octadecenoyl-CoA + H2O <=> (9E)-octadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693125", "l": "RHOF binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0009884", "l": "cytokinin receptor activity", "d": ["Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621116", "l": "FOXO1,FOXO3 bind CITED2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102880", "l": "isobazzanene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> isobazzanene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483219", "l": "PC is exchanged with PI by PITPNB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043751", "l": "polyphosphate:AMP phosphotransferase activity", "d": ["Catalysis of the reaction: (polyphosphate)n + AMP = (polyphosphate)n-1 + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448963", "l": "Interaction of MyoD:E protein with MEF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8865774", "l": "TTLLs polyglutamylate tubulin (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211874", "l": "CYP2S1 4-hydroxylates atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204773", "l": "Interaction of Tie2 and Grb7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32030", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-cuprenene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37082", "l": "2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901238", "l": "ABC-type tungstate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + tungstate(in) = ADP + phosphate + tungstate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45705", "l": "(E)-sinapyl alcohol + NADP(+) => (E)-sinapaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008429", "l": "phosphatidylethanolamine binding", "d": ["Binding to a phosphatidylethanolamine, a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432162", "l": "Unblocking of GRIN1:GRIN2 NMDA receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74711", "l": "Phosphorylation of IRS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168883", "l": "Binding of NS1 to poly(A)-binding protein II (PABII) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35313", "l": "3-oxoisoheptadecanoyl-CoA + H(+) + NADPH => 3-hydroxyisoheptadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49210", "l": "20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730858", "l": "Autophosphorylation of BTK/ITK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009488", "l": "IL34 binds CSF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717841", "l": "holo-FDPS dimer binds NBPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029445", "l": "An unknown GEF exchanges GTP for GDP on CDC42:GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879245", "l": "mycothiol binds formaldehyde and is dehydrogenated (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52028", "l": "a jasmonyl-L-amino acid + H2O = a jasmonate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49073", "l": "dibenzothiophene + 2 FMNH2 + 2 O2 => dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16950", "l": "myo-inositol + NAD(+) => H(+) + NADH + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202233", "l": "Inactivation of Lck by Csk (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674018", "l": "BRAP binds RAS:GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5323526", "l": "FRAT proteins bind GSK3beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66926", "l": "[(R)-3-hydroxyalkanoate](n+1) + CoA => [(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28778", "l": "dinoflagellate luciferin + O2 <=> H(+) + H2O + hnu + oxidized dinoflagellate luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23615", "l": "1,2-dihydro-alpha-santonin + NAD(+) <=> alpha-santonin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102156", "l": "2,5-DHBA UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: 2,5-dihydroxybenzoate + UDP-alpha-D-glucose <=> 2,5-dihydroxybenzoate 5-O-beta-D-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64272", "l": "benzylamine + pyruvate = benzaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0044549", "l": "GTP cyclohydrolase binding", "d": ["Binding to a GTP cyclohydrolase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186765", "l": "PLC-gamma binds to the active receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080124", "l": "pheophytinase activity", "d": ["Catalysis of the reaction: pheophytin + H2O = phytol + pheophorbide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786650", "l": "DDHD1,2 hydrolyse PA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44870", "l": "1,2-diacyl-sn-glycero-3-phosphoethanol + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59288", "l": "beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O = D-glucose + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202307", "l": "Change of PKC theta conformation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32133", "l": "butanoyl-CoA + CO2 => (2S)-ethylmalonyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730903", "l": "Oligomerization of TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21934", "l": "L-homoserine lactone + S-methyl-5'-thioadenosine => S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69874", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S)-22-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36507", "l": "docosanoyl-CoA + H(+) + malonyl-CoA = 3-oxotetracosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64774", "l": "2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol => S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9648017", "l": "EML4 binds to microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018747", "l": "RHOQ GEFs activate RHOQ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857565", "l": "Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981353", "l": "RASA1 stimulates RAS GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684008", "l": "NBN binds KPNA2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24007", "l": "butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693575", "l": "DNA-PKcs autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204863", "l": "Interaction of Tie2 with Ang2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63225", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 => 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68638", "l": "diphosphate + sabinene => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16129", "l": "NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal", "d": []}, {"i": "EC:1.1.1.65", "l": "\"pyridoxine 4-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614605", "l": "Persulfide sulfur is dioxygenated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33974", "l": "5''-phosphoribostamycin + H2O <=> phosphate + ribostamycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209921", "l": "Monoiodinated tyrosine can be deiodinated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75140", "l": "4-hydroxyprotoasukamycin + H(+) + NADH + O2 => asukamycin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46317", "l": "GDP-N,N'-diacetylbacillosamine + H2O => 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.65", "l": "\"sugiol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9677051", "l": "Formation of the PCAF-ATAC complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44431", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34279", "l": "di-trans,poly-cis-dolichol + NADP(+) = di-trans,cis-polyprenol + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.94", "l": "\"polyprenol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35383", "l": "precorrin-6B + S-adenosyl-L-methionine = CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102446", "l": "rhamnetin 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429415", "l": "SYK binds to integrin alphaIIb beta3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71087", "l": "17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) = 17beta-estradiol 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211239", "l": "Association of DFF40 with chromatin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216045", "l": "Collagen type I binds integrin alpha11beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11927", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> globoside Gb3Cer (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102877", "l": "alpha-copaene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> alpha-copaene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21068", "l": "A + H2O + nitrite = AH2 + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37701", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61973", "l": "1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58685", "l": "FAD + 2 H(+) + NADPH + O2 => FADH2-C4alpha-hydroperoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193668", "l": "p75NTR and RHOA-GDI interact (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29074", "l": "a ubiquinone + formate + H(+) <=> a ubiquinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39482", "l": "(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH <=> (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24975", "l": "calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20335", "l": "ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase] => ATP + L-seryl-[acetyl-CoA carboxylase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.138", "l": "\"coumarin 8-geranyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70029", "l": "H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine => N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670049", "l": "Defects in F8 A1 domain accelerate dissociation of the A2 domain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174963", "l": "NAT1 acetylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3209165", "l": "ID1 sequesters ETS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.2", "l": "\"alcohol dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40670", "l": "2-aminoprop-2-enoate <=> 2-iminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018798", "l": "RHOV binds GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16607", "l": "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+) => dodecanoyl-CoA + H2O + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209924", "l": "Dopa is decarboxylated to dopamine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35558", "l": "cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21695", "l": "CDP-glycerol + H2O <=> CMP + 2 H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35599", "l": "NADP(+) + propane-1,3-diol = 3-hydroxypropanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37340", "l": "3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O => (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163310", "l": "TFAM binds to mitochondrial promoters (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21299", "l": "D-galactose + NAD(+) <=> D-galactono-1,4-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42962", "l": "NADH + 2 oxidized [nitric oxide reductase rubredoxin domain] => H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12933", "l": "L-fuculose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate", "d": []}, {"i": "EC:4.1.2.17", "l": "\"L-fuculose-phosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129375", "l": "Elastin cross-linking by lysyl oxidase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864577", "l": "TFAP2C translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420265", "l": "AMY1-3 bind IAPP(34-70) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28181", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate <=> colnelenate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34451", "l": "dTDP-6-deoxy-beta-L-talose = dTDP-beta-L-rhamnose", "d": []}, {"i": "EC:5.1.3.25", "l": "\"dTDP-L-rhamnose 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36825", "l": "CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate => 1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23438", "l": "2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793988", "l": "LUBAC ubiquitinates CFLAR at K351, K353 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13385", "l": "3-oxododecanoate + H(+) = 2-undecanone + CO2", "d": []}, {"i": "EC:4.1.1.56", "l": "\"3-oxolaurate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40486", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19615", "l": "S-adenosyl-L-homocysteine + trimethylsulfonium => dimethyl sulfide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008732", "l": "L-allo-threonine aldolase activity", "d": ["Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853745", "l": "RET binds GFRA1,GFRA3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "44.198123730338018", "identifiers": [{"i": "GO:0005215", "l": "transporter activity", "d": ["Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52043", "l": "L-cystine <=> 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51375", "l": "(9Z)-hexadecenoyl-CoA + glycine <=> CoA + H(+) + N-(9Z-hexadecenoyl)-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9753634", "l": "GGT dimers hydrolyse APAP-SG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29006", "l": "H(+)(out) + L-homoserine(in) <=> H(+)(in) + L-homoserine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74115", "l": "an anthocyanidin + UDP-alpha-D-galactose = an anthocyanidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65218", "l": "3-oxododecanoate + CoA + H(+) => 3-oxododecanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2995388", "l": "PP2A dephosphorylates BANF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981606", "l": "Myoglobin binds oxygen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62971", "l": "(R)-lactate + NADP(+) <=> H(+) + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19138", "l": "17beta-estradiol + AH2 + O2 => 6beta-hydroxyestradiol-17beta + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61497", "l": "an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose => an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37821", "l": "1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10347", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008864", "l": "formyltetrahydrofolate deformylase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.7", "l": "\"cyclic alcohol dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015218", "l": "pyrimidine nucleotide transmembrane transporter activity", "d": ["Enables the transfer of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63479", "l": "NADP(+) + prostaglandin E2 <=> 15-oxoprostaglandin E2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35254", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(in) + ATP + H2O <=> ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41915", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADPH <=> hexadecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000327", "l": "PLK1 phosphorylates BORA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27870", "l": "(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)", "d": []}, {"i": "EC:3.7.1.13", "l": "\"2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60022", "l": "diphosphate + sesquisabinene A => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52779", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59915", "l": "(E)-4-hydroxynon-2-enal + H2O + NADP(+) <=> (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046553", "l": "D-malate dehydrogenase (decarboxylating) activity", "d": ["Catalysis of the reaction: (R)-malate + NAD+ = CO2 + NADH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15608", "l": "H2O + L-serine O-sulfate <=> H(+) + NH4(+) + pyruvate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685607", "l": "Sialic acid binds SIGLEC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11907", "l": "2-amino-4-hydroxypteridine + H(+) + H2O <=> 2,4-dihydroxypteridine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58175", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> beta-pinacene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45533", "l": "H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787820", "l": "IL34 dimer binds CSF1R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426569", "l": "Interaction of DAP12 and IREM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62842", "l": "GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42843", "l": "acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH <=> 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686359", "l": "SFTPs translocate from extracellular region to clathrin-coated vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17510", "l": "H2O + thiamine => 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68521", "l": "(2E,6E)-farnesyl diphosphate => beta-acoradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210290", "l": "Interaction of PECAM-1 and SHIP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44517", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O => (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64082", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP] => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61488", "l": "cytidine(50) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176175", "l": "Stalling of DNA replication fork and RPA binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296045", "l": "Activation of Potassium transport channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47486", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => deoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156699", "l": "Inactivation of Wee1 kinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43609", "l": "agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O => 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706328", "l": "Active FLT3 binds to SOCS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31008", "l": "(S)-2,3-epoxysqualene => beta-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60483", "l": "2 UTP <=> c-di-UMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48054", "l": "n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+) => n 3'-phosphoadenylyl sulfate + dermatan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5578712", "l": "Importin-8 binds AGO2:miRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68759", "l": "4 (R)-3-phenyllactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022B + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27583", "l": "(S)-2-hydroxymethylglutarate => 2-methyleneglutarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686005", "l": "nsp3 binds to nsp7-8 and nsp12-16 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27630", "l": "ethylene glycol + NAD(+) = glycolaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688456", "l": "MLKL binds FLOT1, FLOT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54577", "l": "2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 => an adenosine in tRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61568", "l": "an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40396", "l": "1,2-dihydro-beta-NAD + H(+) + O2 => H2O2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864569", "l": "WWOX binds TFAP2C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20530", "l": "2-cis-(+)-abscisic aldehyde + H2O + O2 => 2-cis-(+)-abscisate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.5.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798748", "l": "Exocytosis of secretory granule lumen proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.63", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106326", "l": "acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696267", "l": "RND3 binds GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21758", "l": "dopamine + secologanin => deacetylisoipecoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74099", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) = ADP + H(+) + L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679028", "l": "JAK3 binds JAK3 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69484", "l": "dodecan-1-ol + O2 = dodecanal + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72278", "l": "oxalate(in) + sulfate(out) <=> oxalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25048", "l": "(2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+) => (2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2509831", "l": "ITPA hydrolyses XTP to XMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50114", "l": "CoA + H(+) + N-octadecanoyl-taurine => octadecanoyl-CoA + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161538", "l": "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632738", "l": "DDIT4 binds 14-3-3 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382058", "l": "Nck binds to the active PDGF receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928597", "l": "EPH:EFN dimers tetramerise (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093332", "l": "p-EPHB phosphorylates SDC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74086", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + menadiol <=> diphosphate + menaquinol-4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45674", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73980", "l": "(2E,6E)-farnesyl diphosphate => calarene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036163", "l": "3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid decarboxylase activity", "d": ["Catalysis of the reaction: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid -> 2-hexaprenyl-6-methoxyphenol + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607734", "l": "PKC-delta translocates to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690152", "l": "USP5 cleaves polyubiquitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30818", "l": "beta-nicotinamide D-ribonucleotide + H2O <=> beta-nicotinamide D-riboside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29474", "l": "D-ribose 5-phosphate + H2O <=> D-ribose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24550", "l": "a carboxylate + L-lysine => an N(6)-acyl-L-lysine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849428", "l": "PTPN1 binds PTK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2666278", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65078", "l": "asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159733", "l": "Furin cleaves pro-factor X to factor X (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73380", "l": "(R)-lipoate(out) + 2 Na(+)(out) => (R)-lipoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62179", "l": "GDP-alpha-D-glucose + H2O <=> alpha-D-glucose 1-phosphate + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47739", "l": "cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35752", "l": "ATP + kanosamine => ADP + D-kanosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198756", "l": "ERK1/2 phosphorylates MSK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211960", "l": "CYP2U1 19-hydroxylates ARA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26410", "l": "H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate", "d": []}, {"i": "EC:4.2.1.126", "l": "\"N-acetylmuramic acid 6-phosphate etherase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16622", "l": "dihydrosanguinarine + H(+) + O2 => H2O2 + sanguinarine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32576", "l": "(2E)-geranyl diphosphate => (1R,5R)-alpha-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54051", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 4-epi-cubebol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018589", "l": "di-n-butyltin dioxygenase activity", "d": ["Catalysis of the reaction: dibutyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutylbutyltin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37195", "l": "octadecanoyl-CoA + sn-glycerol 3-phosphate = 1-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028817", "l": "CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23888", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine = [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.30", "l": "\"cyanophycin synthase (L-arginine-adding)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20574", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376117", "l": "JLP interacts with CDO complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22053", "l": "A + H2O + NH4(+) => AH2 + H(+) + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0070626", "l": "(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity", "d": ["Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14809", "l": "phenol + S-adenosyl-L-methionine = anisole + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.25", "l": "\"phenol O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14063", "l": "glycine + H(+) + NADH + pyruvate => H2O + N-(carboxymethyl)-D-alanine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60280", "l": "L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.367", "l": "\"[histone H3]-lysine(9) N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165195", "l": "GTP loading by Rheb (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210444", "l": "L-Glutamate loading of synaptic vesicle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38500", "l": "a triacyl-sn-glycerol + H2O => a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797810", "l": "PTPRD binds IL1RAPL1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.149", "l": "\"lycopene elongase/hydratase (flavuxanthin-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57359", "l": "2-oxoglutarate + chloride + H(+) + hapalindole U + O2 <=> CO2 + H2O + hapalindole G + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11859", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66517", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58183", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH <=> all-trans-lycopaoctaene + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936412", "l": "RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2172126", "l": "DAP12 interacts with NKG2C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9619355", "l": "CaMKK autophosphorylates in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070005", "l": "cysteine-type aminopeptidase activity", "d": ["Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373140", "l": "isocitrate <=> citrate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51869", "l": "dimethylallyl diphosphate + umbelliferone => demethylsuberosin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.15.4", "l": "\"peptidyl-dipeptidase B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211340", "l": "Anthrax lef cleaves target cell MAP2K1 (MEK1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33459", "l": "H(+) + NADPH + zymosterone = NADP(+) + zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50566", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39963", "l": "2-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23955", "l": "H2O + N-(2-phenylethyl)acetamide <=> 2-phenylethylamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59714", "l": "D-maltotetraonate + H(+) => D-maltotetraono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16670", "l": "H2O + NAD(+) + xanthine => H(+) + NADH + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58058", "l": "2-sulfinoacetaldehyde + L-alanine => hypotaurine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209891", "l": "Dopamine is oxidised to noradrenaline (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51904", "l": "10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196017", "l": "Dynamin is recruited to the gap junction plaque (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19387", "l": "H(+) + raucaffricine + UDP => UDP-alpha-D-glucose + vomilenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750942", "l": "USP14 deubiquitinates NLRC5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39759", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52462", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 17beta-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39068", "l": "3-oxooctanedioyl-CoA + CoA => acetyl-CoA + hexanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353356", "l": "Reversal of Alkylation Damage By DNA Dioxygenases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35855", "l": "1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25327", "l": "H(+) + phosphocholine + S-adenosyl-L-homocysteine => N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678843", "l": "ISGylation of protein translation regulator 4EHP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641229", "l": "TLE oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70423", "l": "an acyl-CoA + H2O = a carboxylate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9761344", "l": "USP18 binds IKBKG within IKK complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68210", "l": "1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA => (7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52187", "l": "(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25482", "l": "acetoacetyl-CoA + succinate => acetoacetate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32149", "l": "6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+) => H2O + sepiapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404142", "l": "atROL binds RBP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782388", "l": "NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71445", "l": "3-O-methyl-L-dopa(in) + L-phenylalanine(out) => 3-O-methyl-L-dopa(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592245", "l": "NRF1:PPARGC1B binds the ALAS1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48386", "l": "a 3-hydroxy fatty acid + H2O => a 2,3-saturated fatty acid + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70009", "l": "2-aminobenzoyl-AMP + diphosphate => anthranilate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64724", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75029", "l": "9-(9Z-hexadecenoyloxy)-octadecanoate + di-(9Z)-hexadecenoylglycerol => 1,2,3-tri-(9Z)-hexadecenoylglycerol + 9-hydroxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645428", "l": "ALPK1 binds ADP-heptose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19852", "l": "H2O + NADP(+) <=> ADP-D-ribose 2'-phosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62117", "l": "H2O + iminosuccinate => NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2186780", "l": "Degradation of Ub-SMAD7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627089", "l": "CASP9 is phosphorylated at T412 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53647", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-corvol ether B + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68187", "l": "a medium-chain fatty acyl-CoA + H2O <=> a medium chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54797", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) => an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182988", "l": "Sprouty lures CBL away from EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852010", "l": "BTNL2 binds activated T cells surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465924", "l": "OPN1LW binds 11cRAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-990489", "l": "Kinesin-13 is a dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001566", "l": "non-kinase phorbol ester receptor activity", "d": ["Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21774", "l": "NH4(+) + uridine(6666) in apoB mRNA => cytidine(6666) in apoB mRNA + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55957", "l": "(9Z)-octadecenoate + AH2 + O2 => (12R)-hydroxy-(9Z)-octadecenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57370", "l": "(6R)-NADPHX => H2O + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40615", "l": "H2O + tridecanoylglycerol = 2,3-didecanoyl-sn-glycerol + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990534", "l": "thermospermine oxidase activity", "d": ["Catalysis of the reaction: S-methyl-5'-thioadenosine + thermospermine + H+ = S-adenosyl 3-(methylthio)propylamine + spermidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45346", "l": "globoside NORint (d18:1(4E)) + H(+) + UDP => globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38839", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48937", "l": "2-oxoglutarate + L-prolyl-[Skp1 protein] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035956", "l": "Defective CYP17A1 does not cleave 17aHPROG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40674", "l": "2-iminopropanoate + H2O <=> NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52735", "l": "3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate <=> adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15884", "l": "ATP + L-seryl-[Fas-activated protein] <=> ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23692", "l": "(R)-malate = H2O + maleate", "d": []}, {"i": "EC:4.2.1.31", "l": "\"maleate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45643", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432946", "l": "PARVB/Affixin interacts with alpha PIX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41384", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65493", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine => 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72261", "l": "3-O-methyl-L-dopa + H(+) + S-adenosyl-L-homocysteine => L-dopa + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13770", "l": "glycerol + NAD(+) => dihydroxyacetone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20933", "l": "L-erythrulose 1-phosphate => dihydroxyacetone phosphate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73729", "l": "Formation of SL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193656", "l": "p75NTR interacts with RIP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247840", "l": "WLS binds WNT ligands in the Golgi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64400", "l": "an L-amino acid tripeptide(out) + H(+)(out) = an L-amino acid tripeptide(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444859", "l": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061758", "l": "2-hydroxyglutarate dehydrogenase activity, forward reaction", "d": ["Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor -> 2-oxoglutarate + reduced acceptor."]}, {"i": "RHEA:21253", "l": "(S)-2-hydroxyglutarate + A => 2-oxoglutarate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956676", "l": "YAP1 binds TP73 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18600", "l": "H(+) + NAD(+) + 2 reduced [rubredoxin] <=> NADH + 2 oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60426", "l": "diphosphate + valerianol => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034857", "l": "2-(methylthio)benzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: 2-(methylthio)benzothiazole + 1/2 O2 = 2-(methylsulfinyl)benzothiazole."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102611", "l": "(+)-secoisolariciresinol monoglucoside glucosyltransferase activity", "d": ["Catalysis of the reaction: (+)-secoisolariciresinol monoglucoside + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol diglucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018113", "l": "lysine racemase activity", "d": ["Catalysis of the reaction: L-lysine = D-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57120", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75762", "l": "(9Z,11E)-octadecadienoate + H2O <=> 10-hydroxy-(11E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33281", "l": "(E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43253", "l": "1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O => 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57139", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933527", "l": "Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67873", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose => 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16186", "l": "an aldehyde + H2O + NAD(+) => a carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875817", "l": "MET phosphorylates STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419011", "l": "Transhomodimerization of Nectins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66615", "l": "N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA <=> methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004017", "l": "adenylate kinase activity", "d": ["Catalysis of the reaction: ATP + AMP = 2 ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65370", "l": "a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28797", "l": "2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54550", "l": "D-xylulose 5-phosphate + phosphate => D-xylulose 1,5-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694495", "l": "RTC binds SARS-CoV-2 genomic RNA complement (minus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990856", "l": "methionyl-initiator methionine tRNA binding", "d": ["Binding to methionine-initator methionine tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53686", "l": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42433", "l": "3-hydroxy-cis,cis-muconate => maleylacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24578", "l": "H(+) + 2 phosphate => diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635843", "l": "GLI translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10691", "l": "H2O + streptomycin 6-phosphate <=> phosphate + streptomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75450", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416683", "l": "SEMA3E binds to PLXND1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10556", "l": "D-glyceraldehyde 3-phosphate + L-arginine = H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate", "d": []}, {"i": "EC:2.5.1.66", "l": "\"N(2)-(2-carboxyethyl)arginine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938913", "l": "RUNX1 binds ELF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71441", "l": "L-dopa(in) + L-phenylalanine(out) => L-dopa(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046566", "l": "DOPA dioxygenase activity", "d": ["Catalysis of the 4,5-ring opening reaction: 3,4-dihydroxyphenylalanine + O2 = 4,5-seco-DOPA. 4,5-seco-DOPA spontaneously recyclizes to form betalamic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374337", "l": "Apelin receptor binds to apelin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63942", "l": "2 Fe(III)-[cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63809", "l": "ATP + citrate + spermidine => AMP + diphosphate + H(+) + N(8)-citryl-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043024", "l": "ribosomal small subunit binding", "d": ["Binding to a small ribosomal subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36806", "l": "2-hydroxy-2,3-dihydrogenistein <=> genistein + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170965", "l": "(Frs2)Rap1-GTP binds to and activates B-Raf (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10592", "l": "a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047751", "l": "3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)", "d": ["Catalysis of the reaction: 3-oxo-5alpha-steroid + NADP+ = a 3-oxo-delta(4)-steroid + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814555", "l": "Integrator complex processes the 3' end of snRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51810", "l": "(9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0051393", "l": "alpha-actinin binding", "d": ["Binding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53952", "l": "4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate = 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10639", "l": "D-mannonate + NADP(+) <=> D-mannuronate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022819", "l": "potassium ion uniporter activity", "d": ["Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28281", "l": "3-sulfino-L-alanine + H2O <=> H(+) + L-alanine + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112118", "l": "Oxidative demethylation of 1-meA damaged DNA by ALKBH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64191", "l": "an N-(fatty acyl)-L-tyrosine + H2O <=> a fatty acid + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17688", "l": "H(+) + uracil 5-carboxylate <=> CO2 + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38102", "l": "a ribonucleoside 5'-triphosphate + phytyl phosphate <=> a ribonucleoside 5'-diphosphate + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018747", "l": "phenanthrene-1,2-epoxide hydrolase activity", "d": ["Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60763", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone <=> CoA + jasmolin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368065", "l": "Expression of NPAS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807872", "l": "Active ARF recruits coatomer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0099583", "l": "neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "d": ["Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32471", "l": "demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] = (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.66", "l": "\"marmesin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813626", "l": "LEAP2 binds bacteria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376149", "l": "Proteolytic processing of SLIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167217", "l": "Phospho-Shc dissociates from the TrkA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69433", "l": "3 [thioredoxin]-dithiol + arsenic triglutathione + 3 S-adenosyl-L-methionine => 3 [thioredoxin]-disulfide + 3 glutathione + 3 H(+) + 3 S-adenosyl-L-homocysteine + trimethylarsine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018451", "l": "epoxide dehydrogenase activity", "d": ["Catalysis of the reaction: ethene oxide + NAD+ + CoA-SH = NADH + H+ + acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17687", "l": "CO2 + uracil => H(+) + uracil 5-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669013", "l": "EDA-3 binds EDA2R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768788", "l": "miR-224 binds NPAS4 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032216", "l": "glucosaminyl-phosphatidylinositol O-acyltransferase activity", "d": ["Catalysis of the reaction: glucosaminyl-phosphatidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phasphotidylinositol + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25246", "l": "(R)-S-lactoylglutathione + H2O => (R)-lactate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66379", "l": "D-erythrose 4-phosphate + H2O <=> D-erythrose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37362", "l": "D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-glucosamine 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0046941", "l": "azetidine-2-carboxylic acid acetyltransferase activity", "d": ["Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21931", "l": "3-dehydro-L-gulonate + NADP(+) <=> 2,3-dioxo-L-gulonate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59969", "l": "L-threonyl-[protein] + octanoyl-CoA => CoA + O-octanoyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31994", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquithujene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41588", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031788", "l": "motilin receptor binding", "d": ["Binding to a motilin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28343", "l": "dITP + H2O => dIMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030251", "l": "guanylate cyclase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of guanylate cyclase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68429", "l": "lutein + O2 => (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R,6R)-hydroxy-alpha-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983424", "l": "Budding of COPII coated vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37002", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57656", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b = CMP + ganglioside GT1balpha + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173725", "l": "C9 binds C5b:C6:C7:C8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58753", "l": "1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869568", "l": "NPM1 binds TFAP2A homodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33453", "l": "AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] => A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2167942", "l": "Collagen type XIII ectodomain shedding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0140905", "l": "haloperoxidase activity", "d": ["Catalysis of the reaction: R-CH + a halogen + H2O2 = R-C-halogen + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12112", "l": "indole-3-pyruvate + S-adenosyl-L-methionine = (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.47", "l": "\"indolepyruvate C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373141", "l": "malate <=> fumarate + H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64897", "l": "2 H2O + UTP => 2 H(+) + 2 phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173723", "l": "C8 binds C5b:C6:C7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15324", "l": "(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0140713", "l": "histone chaperone activity", "d": ["Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome. The histone can be newly synthesized or result from nucleosome disassembly (either spontaneously, or by a histone chaperone)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2509827", "l": "ITPA hydrolyses ITP to IMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22124", "l": "17-O-acetylajmaline + H2O = acetate + ajmaline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9726875", "l": "HCNs:cAMP bind SNIs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42957", "l": "cytidine(38) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203973", "l": "Vesicle budding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14237", "l": "10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine", "d": []}, {"i": "EC:1.14.14.136", "l": "\"deoxysarpagine hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047434", "l": "indolepyruvate decarboxylase activity", "d": ["Catalysis of the reaction: indolepyruvate = CO2 + indole acetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52787", "l": "2-sulfenohercynine + AH2 + H(+) <=> A + ergothioneine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28641", "l": "(-)-gamma-cadinene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061899", "l": "11-cis-retinal 3,4-desaturase activity", "d": ["Catalysis of the reaction: 11-cis-retinal + 2 H+ + O2 + 2 reduced [adrenodoxin] = 11-cis-3,4-didehydro-retinal + 2 H2O + 2 oxidized [adrenodoxin]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800396", "l": "TP53 stimulates PIDD1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71844", "l": "tauroursodeoxycholate(out) => tauroursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508292", "l": "SYK binds IL2RB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36239", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114264", "l": "Translocation of activated BAX to the mitochondria (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38322", "l": "chorismate + H2O <=> (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43440", "l": "hexadecanoate + sphinganine = H2O + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382057", "l": "Release of novel PDGFs as latent factors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0004563", "l": "beta-N-acetylhexosaminidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62464", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47716", "l": "4-pregnen-20,21-diol-3-one + NAD(+) = 21-hydroxyprogesterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70870", "l": "L-alanine(out) + L-glutamine(in) + Na(+)(out) <=> L-alanine(in) + L-glutamine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295599", "l": "SPRY2 translocates to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948034", "l": "FGR binds LDL:LRP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008788", "l": "alpha,alpha-phosphotrehalase activity", "d": ["Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40523", "l": "a quinone + succinate = a quinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14372", "l": "2-phosphoglycolate + H2O <=> glycolate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75785", "l": "ADP(out) => ADP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37087", "l": "[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56616", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene = 1,2,4-trichlorobenzene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31697", "l": "(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211968", "l": "CYP2W1 oxidises INDOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31424", "l": "(2Z,6E)-farnesyl diphosphate => (-)-alpha-cedrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49551", "l": "H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] <=> H(+) + L-arginyl-[protein] + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73316", "l": "1D-chiro-inositol(out) + 2 Na(+)(out) => 1D-chiro-inositol(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68623", "l": "cortisone + H(+) + NADPH <=> 20beta-dihydrocortisone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69163", "l": "agmatine + H2O + O2 <=> H2O2 + N-amidino-(2R)-hydroxypyrrolidine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "64.23035275591424", "identifiers": [{"i": "GO:0030234", "l": "enzyme regulator activity", "d": ["Binds to and modulates the activity of an enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62063", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814831", "l": "TBC1D20 binds RAB1:GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55301", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030625", "l": "U11 snRNA binding", "d": ["Binding to a U11 small nuclear RNA (U11 snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429497", "l": "SLP-76 stimulates PLC gamma 2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29701", "l": "dimethyl sulfoxide(out) => dimethyl sulfoxide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172433", "l": "Collagen type XIX degradation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59941", "l": "2-methyloctadecanoyl-CoA + H2O => 2-methyloctadecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19726", "l": "H(+) + UDP-alpha-D-galacturonate => CO2 + UDP-beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46902", "l": "a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701507", "l": "PTPN6 dephosphorylates JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23082", "l": "2-dehydro-3-deoxy-L-rhamnonate + H2O => L-rhamnonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65829", "l": "H2O + neryl diphosphate => diphosphate + nerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60777", "l": "2-oxoglutarate + gibberellin A12 + O2 => CO2 + gibberellin A15 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620103", "l": "ALDH2 transforms GTN to NO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66196", "l": "acetyl-CoA + tryptamine = CoA + H(+) + N-acetyltryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39882", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58775", "l": "1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030413", "l": "competence pheromone activity", "d": ["A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944225", "l": "Association of procollagen type XVII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218642", "l": "PTK2 autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622627", "l": "BCL6 gene expression is stimulated by FOXO3,FOXO4,(FOXO1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043807", "l": "3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity", "d": ["Catalysis of the reaction: 3-methyl-2-oxobutanoate + CoA + oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804762", "l": "TP53 forms homotetramers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163090", "l": "Elongation Of The Telomeric Chromosome End (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433456", "l": "Recruitment of STATs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49578", "l": "(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine => AH2 + GTP + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162096", "l": "carbovir diphosphate + ATP => carbovir triphosphate + ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374664", "l": "Phosphorylation and activation of Ezrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004918", "l": "interleukin-8 receptor activity", "d": ["Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17872", "l": "5,6,7,8-tetrahydropteridine + NAD(+) <=> 6,7-dihydropteridine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68105", "l": "all-trans-zeaxanthin + O2 => (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77589", "l": "Recognition of AAUAAA sequence by CPSF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23162", "l": "L-rhamnulose => L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51211", "l": "20-hydroxy-leukotriene B4 + NADP(+) <=> 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433451", "l": "JAK2 binds to p-KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41015", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol = 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37065", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine => 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0000400", "l": "four-way junction DNA binding", "d": ["Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12603", "l": "2-oxoadipate + L-glutamate => 2-oxoglutarate + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.22.-.-", "l": "\"Acting on halogen in donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48971", "l": "[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 <=> [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624668", "l": "CEBPA binds CDKN1A (p21) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015042", "l": "trypanothione-disulfide reductase (NADP) activity", "d": ["Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371527", "l": "HSF1 trimer translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607737", "l": "BCL10 oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56528", "l": "chloride + D-tryptophan + FADH2 + O2 = 6-chloro-D-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42701", "l": "6-carboxyhexanoyl-[ACP] methyl ester + H2O => 6-carboxyhexanoyl-[ACP] + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047360", "l": "undecaprenyl-phosphate galactose phosphotransferase activity", "d": ["Catalysis of the reaction: all-trans-undecaprenyl phosphate + UDP-D-galactose = alpha-D-galactosyl-diphosphoundecaprenol + UMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.90", "l": "\"glyceraldehyde-3-phosphate dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788999", "l": "HV1-mediated H+ transfer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032089", "l": "NACHT domain binding", "d": ["Binding to a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg2+-binding site and five more specific motifs."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32011", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-T-muurolol + diphosphate", "d": []}, {"i": "EC:4.2.3.98", "l": "\"(+)-T-muurolol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090589", "l": "protein-phosphocysteine-trehalose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + trehalose (out) = protein cysteine + trehalose-6-phosphate (in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875451", "l": "MET phosphorylates CBL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68207", "l": "1,2-dihexanoylglycerol + octadecanoyl-CoA <=> 1,2-dihexanoyl-3-octadecanoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140840", "l": "RNA polymerase II CTD heptapeptide repeat P6 isomerase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 6) = RNA polymerase II large subunit trans-proline (omega=0) (position 6)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40452", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64862", "l": "(E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine => (E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54509", "l": "all-trans-heptaprenyl diphosphate => beta-heptaprene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48273", "l": "2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22417", "l": "3,4-dihydroxybenzoate + H(+) => catechol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52952", "l": "lithocholate + UDP-alpha-D-glucuronate = lithocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190258", "l": "FGFR2c binds to FGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050454", "l": "coenzyme F420 hydrogenase activity", "d": ["Catalysis of the reaction: coenzyme F420 + H(2) + H+ = reduced coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003944", "l": "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity", "d": ["Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062183", "l": "all-trans retinoic acid 18-hydroxylase activity", "d": ["Catalysis of the reaction: all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-18-hydroxyretinoate + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."]}, {"i": "RHEA:55856", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296309", "l": "HCAR3 binds HCAR3 ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.5", "l": "\"glutamate formimidoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25209", "l": "H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine = acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44257", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050171", "l": "phenol beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902098", "l": "calcitriol binding", "d": ["Binding to calcitriol. Calcitriol (1,25-dihydroxycholecalciferol) is the hormonally active form of vitamin D3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33635", "l": "ATP + CoA + docosanoate = AMP + diphosphate + docosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53338", "l": "H(+) + NADPH + uridine(20) in tRNA => 5,6-dihydrouridine(20) in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50542", "l": "prostaglandin C2 => prostaglandin A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46226", "l": "(E)-ferulate + CoA + H(+) => (E)-feruloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71267", "l": "chloride(out) + L-pipecolate(out) + 2 Na(+)(out) = chloride(in) + L-pipecolate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29732", "l": "beta-maltose(in) => beta-maltose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24269", "l": "2,6-dioxo-6-phenylhexanoate + NADP(+) => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51665", "l": "D-5-phenylhydantoin + H2O => H(+) + N-carbamoyl-D-phenylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.3.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32385", "l": "(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH => (1S,2S,4R)-limonene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25021", "l": "CTP + riboflavin = CDP + FMN + H(+)", "d": []}, {"i": "EC:2.7.1.161", "l": "\"CTP-dependent riboflavin kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611852", "l": "ADRB3 bind ADR,NAd (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706312", "l": "Active FLT3 binds to LCK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25245", "l": "(R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676595", "l": "TRAFs bind RANK:RANKL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.9", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061473", "l": "murein tripeptide carboxypeptidase activity", "d": ["Catalysis of the reaction L-Ala-gamma-D-Glu-meso-Dap (murein tripeptide) + H2O = L-Ala-gamma-D-Glu + meso-diaminopimelate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41484", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32861", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18006", "l": "D-threitol + NADP(+) => D-erythrulose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202489", "l": "Oligomerization of Bcl10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39625", "l": "(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+) => 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45527", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin alpha-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71698", "l": "2 H(+)(out) + L-alanyl-L-aspartate(out) <=> 2 H(+)(in) + L-alanyl-L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5138432", "l": "DVL2 is phosphorylated by PKC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30904", "l": "demethylspheroidene + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + spheroidene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38659", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24339", "l": "a carboxylate + ATP + CoA <=> AMP + an acyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30028", "l": "D-glyceraldehyde + H(+) + NADH => glycerol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37652", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649733", "l": "mature p21 RAS binds GDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134946", "l": "DDX41 ubiquitination by TRIM21 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112435", "l": "Formation of Elongin BC complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25375", "l": "a 2-hydroxy-3-methyl fatty acyl-CoA = a 2-methyl-branched fatty aldehyde + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12545", "l": "2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine => 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41011", "l": "(+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) = (+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17874", "l": "an R-cob(III)alamin(out) + ATP + H2O => ADP + an R-cob(III)alamin(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71492", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) => an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047505", "l": "(-)-menthol monooxygenase activity", "d": ["Catalysis of the reaction: (-)-menthol + H+ + NADPH + O2 = 1,4-menthane-3,8-diol + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45263", "l": "tetracosanoate(out) <=> tetracosanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71416", "l": "3,3',5-triiodo-L-thyronine(out) + L-phenylalanine(in) => 3,3',5-triiodo-L-thyronine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031853", "l": "nociceptin receptor binding", "d": ["Binding to a nociceptin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210273", "l": "Interaction of DAP12 and NKp44 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22272", "l": "(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.121", "l": "\"protopanaxadiol 6-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14055", "l": "3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate => D-arabinose 5-phosphate + H2O + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661517", "l": "LUBAC binds OTULIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50916", "l": "a carboxylate + ATP + H(+) + NADPH = AMP + an aldehyde + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004394", "l": "heparan sulfate 2-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate."]}, {"i": "REACT:R-HSA-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062241", "l": "double strand break-nuclear membrane anchor activity", "d": ["Binding to DNA double strand breaks and the nuclear inner membrane, in order to facilitate DNA repair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23149", "l": "ATP + propanoate => ADP + propanoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686578", "l": "Activated ATM phosphorylates ABL1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54567", "l": "a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O <=> a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47346", "l": "(25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin] => 7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018746", "l": "RHOQ binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17275", "l": "4-hydroxyphenylacetate + 2 H(+) + NADH => (4-hydroxyphenyl)acetaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44414", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-10 => 3-demethylubiquinol-10 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41013", "l": "(+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47996", "l": "1,6-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75705", "l": "14,15-epoxy-12-hydroxy-(10E)-eicosenoate => 12-hydroperoxy-(10E,14Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12763", "l": "3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine => precorrin-3B + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755244", "l": "SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10427", "l": "H2O + N-benzoylglycine <=> benzoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6794346", "l": "NRXNs bind NLGNs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42587", "l": "1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1299338", "l": "Activation of TRESK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0032183", "l": "SUMO binding", "d": ["Binding to the small ubiquitin-like protein SUMO."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39292", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18375", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004703", "l": "G protein-coupled receptor kinase activity", "d": ["Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67310", "l": "(5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one => (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20934", "l": "dihydroxyacetone phosphate + formaldehyde => L-erythrulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186780", "l": "PI3-kinase binds to the active receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72631", "l": "Formation of the cap-binding eIF4F complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654651", "l": "Activated FGFR4 binds FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20895", "l": "butanoyl-CoA + phosphate <=> butanoyl phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68118", "l": "a triacylglycerol + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12130", "l": "2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin] => 2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14028", "l": "H(+) + H2O + sepiapterin <=> NH4(+) + xanthopterin-B2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30432", "l": "(S)-2,3-epoxysqualene => taraxerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.967140482697559", "identifiers": [{"i": "GO:0034212", "l": "peptide N-acetyltransferase activity", "d": ["Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15383", "l": "2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO => O2 + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59735", "l": "biotinyl-5'-AMP + L-lysyl-[protein] <=> AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23352", "l": "2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate semialdehyde", "d": []}, {"i": "EC:2.6.1.19", "l": "\"4-aminobutyrate--2-oxoglutarate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61614", "l": "7-epi-cylindrospermopsin + CO2 + succinate => 2-oxoglutarate + 7-deoxycylindrospermopsin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417829", "l": "P2RY12 binds ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35244", "l": "ADP + H(+) + thiamine diphosphate => adenosine thiamine triphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27534", "l": "(2E,6E)-farnesyl diphosphate + H2O = (3R,6E)-nerolidol + diphosphate", "d": []}, {"i": "EC:4.2.3.49", "l": "\"(3R,6E)-nerolidol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27628", "l": "beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19200", "l": "adenosine 5'-phosphosulfate + NH4(+) <=> adenosine 5'-phosphoramidate + 2 H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052722", "l": "fatty acid in-chain hydroxylase activity", "d": ["Catalysis of the reaction: fatty acid + O2 + 2 NADPH + H+ = fatty acid with in-chain hydroxy group + 2 NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74553", "l": "L-serine + tRNA(Ser) => H2O + L-seryl-tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59526", "l": "9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein] => 9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75793", "l": "(S)-lactate(in) + Na(+)(in) => (S)-lactate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168393", "l": "STAT5 association with GHR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75917", "l": "dihydroxyacetone + H(+) + NADH + NH4(+) => H2O + NAD(+) + serinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40883", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) = (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49609", "l": "2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) => 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74547", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + talarodiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802834", "l": "RAS GTPase mutants don't hydrolyze GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046525", "l": "xylosylprotein 4-beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199169", "l": "MHC Class I interacts with CD160 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37419", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10537", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64268", "l": "emodin anthrone + O2 = emodin + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001147", "l": "transcription termination site sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654409", "l": "Activated FGFR3 binds FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164832", "l": "ATPase synthesizes ATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65330", "l": "AH2 + chrodrimanin H => A + chrodrimanin F", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32155", "l": "7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + 2 H(+) + L-methionine", "d": []}, {"i": "EC:2.4.99.17", "l": "\"S-adenosylmethionine:tRNA ribosyltransferase-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20037", "l": "D-sorbitol 6-phosphate + NADP(+) = aldehydo-D-glucose 6-phosphate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.200", "l": "\"aldose-6-phosphate reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12865", "l": "1-methyladenosine + H2O = 1-methyladenine + D-ribose", "d": []}, {"i": "EC:3.2.2.13", "l": "\"1-methyladenosine nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60339", "l": "N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60265", "l": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30376", "l": "(2E,6E)-farnesyl diphosphate => (+)-thujopsene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67636", "l": "(2S)-2-amino-2'-deoxyadenylo-succinate = dZMP + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036203", "l": "taxoid 14-beta-hydroxylase activity", "d": ["Catalysis of the reaction: 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45697", "l": "N-(acetyl)-sphing-4-enine-1-phosphate(in) => N-(acetyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694527", "l": "Loss of SAR1B GTPase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63196", "l": "(10bR,4aS)-noroxomaritidine + H(+) + NADPH = (10bR,4aS)-oxomaritidine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043718", "l": "2-hydroxymethylglutarate dehydrogenase activity", "d": ["Catalysis of the reaction: 2-(hydroxymethyl)glutarate + NAD+ = 2-formylglutarate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71064", "l": "L-arginine(in) + L-histidine(out) => L-arginine(out) + L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0016530", "l": "metallochaperone activity", "d": ["Binding to and delivering metal ions to a target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-481044", "l": "Surface deployment of platelet alpha granule membrane components (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72419", "l": "(E)-4-coumarate + ATP + H(+) = (E)-4-coumaroyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72755", "l": "3 ATP = 3',3',3'-c-tri-AMP + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46698", "l": "an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine => a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21104", "l": "AH2 + cholesterol + O2 = 25-hydroxycholesterol + A + H2O", "d": []}, {"i": "EC:1.14.99.38", "l": "\"cholesterol 25-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70773", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26469", "l": "a 2-demethylmenaquinone + S-adenosyl-L-methionine <=> a menaquinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58316", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58240", "l": "H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] = ADP-D-ribose + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64837", "l": "2-phenylethanol + acetyl-CoA => CoA + phenethyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362549", "l": "Hh-Np traffics to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429415", "l": "SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58548", "l": "2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54652", "l": "peregrinol diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}, {"i": "EC:4.2.1.174", "l": "\"peregrinol diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56255", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5620975", "l": "MLKL binds PIPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0140665", "l": "ATP-dependent H3-H4 histone complex chaperone activity", "d": ["A histone chaperone that carries a H3-H4 histone complex, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865320", "l": "CBFB binds RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784765", "l": "p-Y705-STAT3 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941312", "l": "TUT4,TUT7 oligouridylate mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74009", "l": "[(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + diphosphate => dimethylallyl diphosphate + H2O + yaequinolone E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.61", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618582", "l": "CEBPA binds MYC gene:E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38639", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617484", "l": "EGR2 (KROX20) activates HOXA2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4647593", "l": "EP400 binds CDKN1A promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57718", "l": "carbamate + H(+) + H2O => hydrogencarbonate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.990900157612501", "identifiers": [{"i": "GO:0003729", "l": "mRNA binding", "d": ["Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71987", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + fusoxypene C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23347", "l": "a purine D-ribonucleoside + H2O <=> a purine nucleobase + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70573", "l": "D-glucose(in) + Na(+)(in) => D-glucose(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102252", "l": "cellulose 1,4-beta-cellobiosidase activity (reducing end)", "d": ["Catalysis of the reaction: n H2O + a cellodextrin = n beta-cellobiose, releasing cellobiose from the reducing ends of the chains."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30426", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-delta-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68417", "l": "cis-(homo)2aconitate + H2O => (2R,3S)-iso(homo)2citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013143", "l": "RAC1 GEFs activate RAC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14304", "l": "4-pyridoxolactone + H2O <=> 4-pyridoxate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391934", "l": "DP2 receptor can bind PGD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61905", "l": "betaenone A + H(+) + NADPH + O2 => H2O + NADP(+) + stemphyloxin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30000", "l": "ATP + H2O + spermidine(out) => ADP + H(+) + phosphate + spermidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622737", "l": "FOXO3,FOXO6,(FOXO1) binds CAT gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9732527", "l": "FFAR1 binds rosiglitazone (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20089", "l": "acetyl-CoA + L-leucine = CoA + H(+) + N-acetyl-L-leucine", "d": []}, {"i": "EC:2.3.1.66", "l": "\"leucine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008855", "l": "exodeoxyribonuclease VII activity", "d": ["Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30272", "l": "2 (3,4-dimethoxyphenyl)methanol + H2O2 => 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.11", "l": "\"ABC-type methionine transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853745", "l": "RET binds GFRA1,GFRA3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25121", "l": "(S)-2-amino-6-oxohexanoate = H(+) + H2O + L-1-piperideine-6-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15663", "l": "an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA => (E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14417", "l": "acetyl phosphate + L-lysine = H(+) + N(6)-acetyl-L-lysine + phosphate", "d": []}, {"i": "EC:2.3.1.32", "l": "\"lysine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14108", "l": "L-proline + NAD(+) <=> 1-pyrroline-5-carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38023", "l": "gamma-tocotrienol = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14468", "l": "H2O + L-histidinol phosphate <=> L-histidinol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14527", "l": "AH2 + alpha-cyclopiazonate => A + beta-cyclopiazonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448744", "l": "IL20RA binds IL20RB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69380", "l": "2-hydroxy-4-methylpentanoate + O2 = 4-methyl-2-oxopentanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10117", "l": "6-phospho-D-gluconate + NADP(+) => CO2 + D-ribulose 5-phosphate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61150", "l": "H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP => myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31488", "l": "soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose => H(+) + soyasaponin III + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37587", "l": "2-oxoglutarate + D-lysine = 6-amino-2-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212642", "l": "L-Glutamine transport into neurons (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66185", "l": "3',5'-cyclic AMP(in) + ATP + H2O => 3',5'-cyclic AMP(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.576969997299727", "identifiers": [{"i": "GO:0046943", "l": "carboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)."]}, {"i": "REACT:R-HSA-390347", "l": "Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673231", "l": "GGCX does not gamma-carboxylate 3D-F9(29-461) (pro-factor IX) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17956", "l": "3-hydroxyanthranilate + O2 <=> (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16562", "l": "H2O + squalene => hopan-22-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730882", "l": "Phosphorylation of PKC-theta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912378", "l": "Sialylation of Pre-NOTCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57314", "l": "cytidine 5'-diphosphoramidate + H(+) + L-glutamate => H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250947", "l": "B-WICH complex binds rDNA promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54911", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH <=> (4E)-hexenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.90", "l": "\"togavirin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49146", "l": "dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26201", "l": "ammeline + H(+) + H2O = ammelide + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018647", "l": "phenanthrene 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69024", "l": "H(+) + N-hydroxy-L-aspartate + NADPH + O2 = H2O + N,N-dihydroxy-L-aspartate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610723", "l": "GLI proteins bind SUFU (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380311", "l": "Recruitment of Plk1 to centrosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201611", "l": "Caspase-mediated cleavage of Rock-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62045", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O => (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72412", "l": "inulobiose => alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10081", "l": "dihydrophloroglucinol + NADP(+) => 1,3,5-trihydroxybenzene + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050532", "l": "2-phosphosulfolactate phosphatase activity", "d": ["Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate + H2O = (R)-3-sulfolactate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66666", "l": "ADP + coproporphyrin III(out) + H(+) + phosphate => ATP + coproporphyrin III(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046932", "l": "sodium-transporting ATP synthase activity, rotational mechanism", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) => ATP + H2O + Na+(in), by a rotational mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52206", "l": "butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] => butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.120", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426144", "l": "SREBP1A,2 binds the MVD promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850534", "l": "PDCL promotes G-protein beta 5 folding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937177", "l": "AHR:TCDD binds ARNT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389026", "l": "Galanin receptors can bind galanin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12663", "l": "CoA + O-hexadecanoyl-(R)-carnitine => (R)-carnitine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11153", "l": "5-pyridoxate + NADPH + O2 => 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378956", "l": "Luteinizing hormone is a heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45336", "l": "(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine = [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA", "d": []}, {"i": "EC:2.3.1.250", "l": "\"[Wnt protein] O-palmitoleoyl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58391", "l": "4-aminobenzoate + all-trans-hexaprenyl diphosphate <=> 4-amino-3-all-trans-hexaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13280", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate <=> [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033992", "l": "1,5-anhydro-D-fructose dehydratase activity", "d": ["Catalysis of the reaction: 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905060", "l": "calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "d": ["Any calcium:cation antiporter activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869590", "l": "The APOE gene transcription is stimulated by the complex of TFAP2A homodimer and DEK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13474", "l": "H2O + L-tryptophan + NAD(+) => H(+) + indole-3-pyruvate + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14872", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23765", "l": "diphosphate + L-serine => H(+) + O-phospho-L-serine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24002", "l": "a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein] => a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.109", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990919", "l": "proteasome-nuclear membrane anchor activity", "d": ["The binding activity of a molecule that brings together a proteasome complex and a nuclear inner membrane, to maintain the nuclear membrane localization of the proteasome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.41", "l": "\"cathepsin F\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50577", "l": "acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814409", "l": "CK2 phosphorylates PDCL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17691", "l": "adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + glycochenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43255", "l": "1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O <=> 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21245", "l": "an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine => an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49840", "l": "(-)-dehydrodiconiferyl acid + 2 a quinone + H2O = (-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.2.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174119", "l": "Free APC/C phosphorylated by Plk1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52279", "l": "(6S)-5,6,7,8-tetrahydrofolate + vanillate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25809", "l": "H2O + O2 + spermidine => 3-aminopropanal + H2O2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77068", "l": "Activation of GT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106348", "l": "U2 snRNA adenosine m6 methytransferase activity", "d": ["Catalysis of the reaction: a adenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-adenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53621", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (-)-spiroviolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850961", "l": "PREX2 binds PTEN and inhibits it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59950", "l": "CoA + H(+) + prostaglandin F2alpha => H2O + prostaglandin F2alpha-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672817", "l": "Active MTORC1 binds the ULK1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40827", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51070", "l": "(3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine => (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75257", "l": "3'-dehydromangiferin + H2O2 => mangiferin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45626", "l": "AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein] => ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.18", "l": "\"polysaccharide O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201515", "l": "Active ALK recruits PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851908", "l": "Activated MET binds GAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667052", "l": "ROPN1 binds RHOA:GTP:RHPN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41456", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63159", "l": "H2O + N-docosanoyl-taurine <=> docosanoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183052", "l": "CBL binds to GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68255", "l": "L-tryptophan(in) + Na(+)(in) <=> L-tryptophan(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14185", "l": "3-phenylpyruvate + H(+) = 2-phenylacetaldehyde + CO2", "d": []}, {"i": "EC:4.1.1.43", "l": "\"phenylpyruvate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419334", "l": "Melatonin receptors can bind melatonin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2219524", "l": "PDPK1 binds PIP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011300", "l": "ZSWIM8 ubiquitinates ROBO3.1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693250", "l": "RHOD binds effectors at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37385", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10917", "l": "(1R,2R,3R)-prephytoene diphosphate => all-trans-phytoene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950766", "l": "IL27RA dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0034485", "l": "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "d": ["1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35562", "l": "H(+) + menaquinone-7 + NADH <=> menaquinol-7 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21616", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "d": []}, {"i": "EC:2.4.3.4", "l": "\"beta-galactoside alpha-2,3-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592398", "l": "Activation of proMMP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400012", "l": "Acetylcholine binds Muscarinic Acetylcholine Receptor M3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018792", "l": "bis(4-chlorophenyl)acetate decarboxylase activity", "d": ["Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684309", "l": "3CLp cleaves nsp6-11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57467", "l": "(E)-caffeate + UDP-alpha-D-glucose <=> 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202111", "l": "AKT1 phosphorylates eNOS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35049", "l": "AMP + H2O + Mo-molybdopterin => adenylyl-molybdopterin + H(+) + molybdate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56480", "l": "(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63653", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30348", "l": "ATP + IDP => ADP + ITP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696323", "l": "CNRs bind CNR agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36206", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.99.1", "l": "\"dATP(dGTP)--DNA purinetransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28538", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) = ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696275", "l": "RND2 binds GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50387", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline <=> 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9626816", "l": "PIN1 binds p-S345-NCF1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.73", "l": "\"licheninase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082391", "l": "Trimerization of HSF1 in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75421", "l": "(S)-acetoin + H(+) + NADH => (R,S)-butane-2,3-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28278", "l": "3-sulfino-L-alanine + H2O = H(+) + L-alanine + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36497", "l": "ADP + alpha-D-glucose 6-phosphate + H(+) => alpha-D-glucose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36258", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28235", "l": "L-glutamate 5-semialdehyde => (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18546", "l": "2-dehydro-3-deoxy-L-arabinonate => glycolaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70918", "l": "guanosine(in) + H(+)(in) <=> guanosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28796", "l": "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018808", "l": "RAC3 binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951676", "l": "RUNX3 binds TEADs and YAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18795", "l": "D-ribose 5-phosphate => alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70032", "l": "6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684096", "l": "CDK2 phosphorylates RBBP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112392", "l": "Resumption of elongation after recovery from pausing (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39843", "l": "1,3-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16040", "l": "phosphate + thymidine <=> 2-deoxy-alpha-D-ribose 1-phosphate + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112396", "l": "Separation of elongating transcript from template (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73211", "l": "H(+)(in) + sucrose(out) = H(+)(out) + sucrose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19662", "l": "D-mannitol 1-phosphate + NAD(+) => beta-D-fructose 6-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28837", "l": "citrate(in) + succinate(out) => citrate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35294", "l": "11-methyldodecanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxoisopentadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71186", "l": "L-kynurenine(out) + L-tryptophan(in) <=> L-kynurenine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617179", "l": "PRKACA phosphorylates TNNI3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227775", "l": "TRAF6/or TRAF2 interacts with IPS-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50036", "l": "choloyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.651613913496419", "identifiers": [{"i": "GO:0019829", "l": "ATPase-coupled monoatomic cation transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63331", "l": "2-(9Z-octadecenoyl)-glycerol + ATP <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17796", "l": "H2O + L-alanyl-tRNA(Thr) <=> H(+) + L-alanine + tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57200", "l": "glyoxal + L-arginyl-[protein] = N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24313", "l": "L-lysyl-[cytochrome c] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937613", "l": "CRHBP binds CRH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45025", "l": "cholesterol + H(+) + NADPH + O2 => 7-dehydrocholesterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43424", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17655", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + diphosphate => (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190693", "l": "Synthesis of GJB1 (Cx32) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671742", "l": "JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610720", "l": "PKA phosphorylates GLI3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59835", "l": "ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69842", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S)-22-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11270", "l": "H(+) + hydrogen sulfide + NH4(+) + pyruvate => D-cysteine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004066", "l": "asparagine synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15489", "l": "adenosine + H2O + 2 O2 = 9-riburonosyladenine + H(+) + 2 H2O2", "d": []}, {"i": "EC:1.1.3.39", "l": "\"nucleoside oxidase (H2O2-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50676", "l": "H(+) + H2O + N-terminal L-asparaginyl-[protein] = N-terminal L-aspartyl-[protein] + NH4(+)", "d": []}, {"i": "EC:3.5.1.121", "l": "\"protein N-terminal asparagine amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4411383", "l": "NLK phosphorylates TCF/LEF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58699", "l": "NADPH + O2 + rifampicin <=> H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0016416", "l": "O-palmitoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389354", "l": "Activation of Vav1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170120", "l": "Translocation of Cdc25B to the cytoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35300", "l": "3-hydroxyoctadecanoyl-CoA + NADP(+) => 3-oxooctadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250264", "l": "TXNIP binds reduced thioredoxin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41719", "l": "a 2-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59609", "l": "beta-alanyl-L-lysine + H2O => beta-alanine + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851038", "l": "BTN3A1 binds prenylated phosphoantigens (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847968", "l": "PTEN binds FRK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60521", "l": "2 H2O + L-cystine-bis-glycine => 2 glycine + L-cystine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51820", "l": "ATP(in) + CoA(in) + decanoate(out) + H(+)(out) = AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71669", "l": "malonate(in) + succinate(out) => malonate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60791", "l": "gibberellin A24 + H(+) + O2 <=> CO2 + gibberellin A9 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61059", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047157", "l": "myelin-proteolipid O-palmitoyltransferase activity", "d": ["Catalysis of the reaction: [myelin proteolipid] + palmityl-CoA = [myelin proteolipid] O-palmitoylprotein + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451900", "l": "IL2RB binds JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140860", "l": "(3R)-2'-hydroxyisoflavanone reductase activity", "d": ["Catalysis of the reaction: a (3R,4R)-4,2'-dihydroxyisoflavan + NADP+ = a (3R)-2'-hydroxyisoflavanone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374664", "l": "Phosphorylation and activation of Ezrin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72272", "l": "formate(out) + oxalate(in) => formate(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62142", "l": "dTDP + GDP => dTMP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008551", "l": "P-type cadmium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) -> ADP + phosphate + Cd2+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61336", "l": "ATP + H2O + protoporphyrin IX(in) = ADP + H(+) + phosphate + protoporphyrin IX(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050261", "l": "ribose isomerase activity", "d": ["Catalysis of the reaction: ribofuranose = D-ribulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11743", "l": "2 glutathione + NADP(+) <=> glutathione disulfide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373074", "l": "Receptor CCR9  binds CCL25 ligand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852013", "l": "BTNL8 binds resting T cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047428", "l": "arylacetonitrilase activity", "d": ["Catalysis of the reaction: 2 H2O + 4-chlorophenylacetonitrile = 4-chlorophenylacetate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480204", "l": "POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2203516", "l": "Alpha-1-Microglobulin is cleaved (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12847", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate => [L-4-(L-arginin-2-N-yl)aspartate](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42515", "l": "5-acetamidopentanoate + H2O <=> 5-aminopentanoate + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38309", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694563", "l": "ABHD10 hydrolyses MPAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43512", "l": "2-(dihydroxymethyl)-5-formylfuran + O2 = 2-carboxy-5-formylfuran + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34233", "l": "4-nitro-6-oxohepta-2,4-dienedioate + H(+) => 5-nitrosalicylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29981", "l": "2'-deoxyadenosine(out) + H(+)(out) => 2'-deoxyadenosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102764", "l": "6-deoxotyphasterol C-23 hydroxylase activity", "d": ["Catalysis of the reaction: 6-deoxotyphasterol + O2 + a reduced electron acceptor = 6-deoxocastasterone + H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102471", "l": "2-hydroxynaringenin-6C-glucoside dehydratase activity", "d": ["Catalysis of the reaction: 6C-glucosyl-2-hydroxynaringenin <=> isovitexin-7-olate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396009", "l": "STING binds c-di-GMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63585", "l": "2-deoxyecdysone 22-phosphate + H2O => 2-deoxyecdysone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67083", "l": "a very long-chain fatty acid(in) + ATP + H2O <=> a very long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56939", "l": "17beta-hydroxy-androst-5-en-3-one <=> testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24610", "l": "2,5-dioxopentanoate + CO2 + H2O => 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013009", "l": "RHOA binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5631941", "l": "SESN1,2,3 bind AMPK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51229", "l": "17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate => 17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23829", "l": "2-dehydro-D-gluconate + NADP(+) => 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13862", "l": "D-xylose + NAD(+) => D-xylono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16804", "l": "3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] <=> adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9794523", "l": "SLC22A1 transports Cipro into renal cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17924", "l": "D-arabinitol + NAD(+) <=> D-xylulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59854", "l": "(R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+) => (2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75622", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate <=> ectocarpin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-205244", "l": "Recruitment of CBL to KIT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47339", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823977", "l": "Expression of GATA6 in definitive endoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52848", "l": "5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine = 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033729", "l": "anthocyanidin reductase activity", "d": ["Catalysis of the reaction: a flavan-3-ol + 2 NAD(P)+ = an anthocyanidin + 2 NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62632", "l": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O", "d": []}, {"i": "EC:1.11.1.27", "l": "\"glutathione-dependent peroxiredoxin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45476", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981610", "l": "Neuroglobin binds oxygen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.92", "l": "\"fatty acid alpha-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24667", "l": "2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 <=> H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37873", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+) => 2-heptyl-4(1H)-quinolone + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12895", "l": "prostaglandin E2 => prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45053", "l": "(2E)-butenoyl-CoA + (R)-carnitine => CoA + O-(2E)-butenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69685", "l": "CHEK2 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22785", "l": "(2R)-O-phospho-3-sulfolactate => H(+) + phosphoenolpyruvate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.15", "l": "\"mycothione reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950364", "l": "IL23R in IL23:IL23 receptor complex is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20321", "l": "L-proline + NAD(+) = 1-pyrroline-2-carboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350651", "l": "Caspase-mediated cleavage of MASK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449087", "l": "CD4 binds Interleukin-16 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050562", "l": "lysine-tRNA(Pyl) ligase activity", "d": ["Catalysis of the reaction: tRNA(Pyl) + L-lysine + ATP = L-lysyl-tRNA(Pyl) + diphosphate + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49384", "l": "(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875558", "l": "RAPGEF1 binds CRK,CRKL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41714", "l": "a 2-acyl-sn-glycerol 3-phosphate + choline + H(+) => a 2-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67021", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68730", "l": "3beta-hydroxy-lanosta-8, 24-dien-26-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 26-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48703", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol <=> a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48875", "l": "a gentamycin + GTP <=> a gentamycin 2''-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45497", "l": "phycocyanobilin-L-cysteinyl(84)-[allophycocyanin alpha-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753634", "l": "GGT dimers hydrolyse APAP-SG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63644", "l": "GDP-beta-L-fucose + L-seryl-[protein] = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114284", "l": "Release of Cytochrome c from mitochondria (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67442", "l": "acetate + L-methionine => H2O + N(alpha)-acetyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57875", "l": "(E)-2,4-dihydroxycinnamoyl-CoA <=> CoA + umbelliferone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190256", "l": "FGFR1c binds to FGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12662", "l": "(R)-carnitine + hexadecanoyl-CoA => CoA + O-hexadecanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33337", "l": "1,2-dioctadecanoyl-sn-glycerol + phosphate => 1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17623", "l": "(3S)-citramalyl-CoA + acetate => acetyl-CoA + citramalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2203479", "l": "STAB2 (FEEL-2) binds ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20240", "l": "(1S,4S)-5-oxo-1,2-campholide <=> [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019182", "l": "histamine-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029690", "l": "Caspase-6 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34763", "l": "(S,S)-tartrate(out) + succinate(in) = (S,S)-tartrate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31960", "l": "9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68260", "l": "D-serine(in) + Na(+)(in) = D-serine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430158", "l": "p-SLP-76 binds VAV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39044", "l": "22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] => docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48430", "l": "(9Z,12Z)-octadecadienoate + glycerol + H(+) => 1-(9Z,12Z-octadecadienoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.148", "l": "\"estradiol 17alpha-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938108", "l": "SERPINB13 binds cathepsin L (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14094", "l": "2-oxoglutarate + L-tryptophan => indole-3-pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70122", "l": "6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018727", "l": "2-phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: 2-phenanthrol + X-SO3(-) = HX + 2-phenanthrylsulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69476", "l": "acetyl-CoA + L-lysine = CoA + H(+) + N(6)-acetyl-L-lysine", "d": []}, {"i": "EC:2.3.1.306", "l": "\"acetyl-CoA:lysine N(6)-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61585", "l": "cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75522", "l": "FMNH2 + N-acetyl-S-benzyl-L-cysteine + O2 <=> (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72446", "l": "(E)-feruloyl-AMP + CoA <=> (E)-feruloyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36572", "l": "sphinganine + tetradecanoyl-CoA => CoA + H(+) + N-(tetradecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55589", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base => a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112385", "l": "Addition of nucleotides leads to transcript elongation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36195", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63549", "l": "angiotensin-(1-9) + H2O => angiotensin-(1-7) + L-phenylalanyl-L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76416", "l": "Benzene is hydroxylated to phenol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928625", "l": "PAKs autophosphorylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38385", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52538", "l": "AMP + dGDP + H(+) => adenosine + dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49323", "l": "all-trans-violaxanthin <=> (5R,6S)-5,6-epoxi-capsanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67002", "l": "3 CO2 + 4 CoA + phlorisobutanophenone => 2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382057", "l": "Release of novel PDGFs as latent factors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72215", "l": "2 hydrogencarbonate(out) + Na(+)(out) = 2 hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50129", "l": "NAD(+) + resolvin D1 => 17-oxoresolvin D1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58819", "l": "ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683792", "l": "p-T68-CHEK2 autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51792", "l": "H(+) + NADH + O2 + salicylate = 2,3-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73721", "l": "H(+) + S-adenosyl-L-homocysteine + vanillate => 3,4-dihydroxybenzoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803892", "l": "SFN dimer binds BAX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65189", "l": "2-oxoglutarate + berkeleyone B + O2 => berkeleydione + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17999", "l": "Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-2 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69659", "l": "H2O + kaempferol 3-O-beta-D-glucoside = beta-D-glucose + kaempferol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17590", "l": "2,2'-iminodipropanoate + H2O + NAD(+) => H(+) + L-alanine + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14916", "l": "AMP + thymidine <=> adenosine + dTMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37922", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18453", "l": "[(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O = [(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate", "d": []}, {"i": "EC:7.5.2.3", "l": "\"ABC-type beta-glucan transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299338", "l": "Activation of TRESK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16741", "l": "a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA", "d": []}, {"i": "EC:2.3.1.22", "l": "\"2-acylglycerol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47584", "l": "ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GT1c (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9681616", "l": "AP2 binds chlorpromazine (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68960", "l": "DNA polymerase epsilon binds at the origin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805103", "l": "AURKA phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624949", "l": "Assembly of the anterograde IFT train (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352893", "l": "glucose 6-phosphate <=> fructose 6-phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67783", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799409", "l": "HIPK2 phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62693", "l": "2 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + O2 => 2 H(+) + 2 H2O + 2 tellimagrandin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4411402", "l": "Activation of NLK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61138", "l": "CO2 + H(+) + H2O + quercetin + succinate => (2R,3R)-dihydroquercetin + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12818", "l": "2,3-dihydrobiochanin A + NADP(+) => biochanin A + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.117", "l": "\"hydroxycinnamoyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5633460", "l": "MDM2 binds TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41417", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159773", "l": "Furin cleaves pro-protein S to protein S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16847", "l": "citrate + CoA + H(+) => acetyl-CoA + H2O + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371467", "l": "SIRT1 deacetylates HSF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12379", "l": "ATP + L-fuculose <=> ADP + H(+) + L-fuculose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693012", "l": "TNFSF15 binds TNFRSF25 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36394", "l": "cholesterol + NADP(+) <=> desmosterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52479", "l": "estrone + UDP-alpha-D-glucuronate <=> estrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36624", "l": "3-phenylpyruvate + S-adenosyl-L-methionine => (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781840", "l": "ERCC6 binds stalled RNA Pol II (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928604", "l": "SFKs phosphorylate VAV2,3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043791", "l": "dimethylamine methyltransferase activity", "d": ["Catalysis of the reaction: dimethylamine + a dimethylamine corrinoid protein = a methylated dimethylamine corrinoid protein + methylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990882", "l": "CDK1 phosphorylates NUP98 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757256", "l": "MCM3 binds MCM5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004081", "l": "bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity", "d": ["Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823950", "l": "Expression of CXCR4 in definitive endoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43731", "l": "methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176956", "l": "Formation of GINS complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38940", "l": "dioscin + 2 H2O => diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.6", "l": "\"catalase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173739", "l": "Spontaneous hydrolysis of C3 thioester (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20035", "l": "penicillin N => isopenicillin N", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63476", "l": "NADP(+) + prostaglandin E2 = 15-oxoprostaglandin E2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43199", "l": "adenosine(4) in tRNA(His) + S-adenosyl-L-methionine <=> 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001785", "l": "prostaglandin J receptor activity", "d": ["Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10897", "l": "2 H2O + limonin => 2 H(+) + limonoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24583", "l": "D-sorbitol 6-phosphate + H2O <=> D-sorbitol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.3", "l": "\"glycerol-3-phosphate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59788", "l": "H2O + NAD(+) + pseudopaline = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028724", "l": "AMOT proteins bind YAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448627", "l": "Interleukin-35 translocates from the ER lumen to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912627", "l": "CBL ubiquitinates PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381087", "l": "Dimerization of PERK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35602", "l": "NADP(+) + propane-1,3-diol <=> 3-hydroxypropanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15897", "l": "4-acetamidobutanoate + H2O = 4-aminobutanoate + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58352", "l": "2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55492", "l": "ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] = ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388900", "l": "Neurotensin receptors can bind neurotensins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10330", "l": "a 2-hydroxycarbonyl + H(+) + NADH => an L-glycol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34374", "l": "H2O + indole-3-acetamide <=> (indol-3-yl)acetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28494", "l": "a menaquinone + dimethyl sulfide + H2O = a menaquinol + dimethyl sulfoxide", "d": []}, {"i": "EC:1.8.5.3", "l": "\"respiratory dimethylsulfoxide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36441", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76019", "l": "cortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-hydroxycortisol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22303", "l": "a flavonol + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52683", "l": "acetyl-CoA + L-alpha-phenylglycine <=> CoA + H(+) + N-acetyl-L-alpha-phenylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801101", "l": "RABGGTA binds RABGGTB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59539", "l": "ATP + butanoyl-CoA + hydrogencarbonate <=> (2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57235", "l": "GDP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12689", "l": "2 mycothiol + NAD(+) = H(+) + mycothione + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174119", "l": "Free APC/C phosphorylated by Plk1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8857686", "l": "FITM1, FITM2 bind TAGs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35246", "l": "ADP + H(+) + thiamine diphosphate <=> adenosine thiamine triphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977629", "l": "Displacement of C2a/Bb by CR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612076", "l": "p-4S, T366 ELK1:SRF bind EGR1 and EGR2 gene promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762209", "l": "BACH1 is phosphorylated at tyrosine 483 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-76052", "l": "Binding of TFIIIA To type 1 Promoter (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68899", "l": "4-hydroxybenzoate + ATP + H(+) + NADPH <=> 4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620663", "l": "EGR1 binds the VGF gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30756", "l": "ATP + carbamate => ADP + carbamoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0019113", "l": "limonene monooxygenase activity", "d": ["Catalysis of a monooxygenase reaction in which oxygen is incorporated into limonene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28442", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + dodecanoyl-[ACP] = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47953", "l": "[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O => [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050507", "l": "indoxyl-UDPG glucosyltransferase activity", "d": ["Catalysis of the reaction: indoxyl + UDP-D-glucose = H+ + indican + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042018", "l": "interleukin-22 receptor activity", "d": ["Combining with interleukin-22 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66508", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72377", "l": "hydrogencarbonate(in) + iodide(out) => hydrogencarbonate(out) + iodide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69074", "l": "Formation of Processive Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46555", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25150", "l": "(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde <=> H(+) + H2O + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635861", "l": "NUMB:ITCH binds GLI1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52447", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose <=> 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60262", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29312", "l": "FMNH2 + O2 + sulfoacetate => FMN + glyoxylate + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046180", "l": "KSPG is secreted from the cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9659611", "l": "ANO1 inhibitors bind ANO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66413", "l": "ATP + glutathione(in) + H2O + taurochenodeoxycholate(in) => ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73464", "l": "carcinine + H2O => beta-alanine + histamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193068", "l": "CYP17A1 17-hydroxylates PREG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15316", "l": "ethanolamine <=> acetaldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046905", "l": "15-cis-phytoene synthase activity", "d": ["Catalysis of the reaction: 2 geranylgeranyl diphosphate -> 15-cis-phytoene + 2 diphosphate."]}, {"i": "RHEA:34479", "l": "(1R,2R,3R)-prephytoene diphosphate = 15-cis-phytoene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374664", "l": "Phosphorylation and activation of Ezrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667965", "l": "ANKLE2 binds PP2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047782", "l": "coniferin beta-glucosidase activity", "d": ["Catalysis of the reaction: H2O + coniferin = D-glucose + coniferol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951727", "l": "cAMP binds PKA tetramer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14281", "l": "2 Fe(III)-[cytochrome c] + H2O + sulfite = 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfate", "d": []}, {"i": "EC:1.8.2.1", "l": "\"sulfite dehydrogenase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37555", "l": "D-kanosamine 6-phosphate + H2O = kanosamine + phosphate", "d": []}, {"i": "EC:3.1.3.92", "l": "\"kanosamine-6-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2129375", "l": "Elastin cross-linking by lysyl oxidase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.576939455547432", "identifiers": [{"i": "GO:0022835", "l": "transmitter-gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851919", "l": "Activated MET binds GAB1 and GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27322", "l": "3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2025890", "l": "Calcineurin binds NFATC1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40793", "l": "CoA + H(+) + hexacosanoate => H2O + hexacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76011", "l": "(3R)-hydroxybutanoate tetramer + H2O = (3R)-hydroxybutanoate trimer + (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35926", "l": "neamine + UDP-alpha-D-glucose <=> 3''-deamino-3''-hydroxykanamycin B + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008466", "l": "glycogenin glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112037", "l": "Inactivation of PLC beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.88", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938338", "l": "NFE2 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69483", "l": "an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39923", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43148", "l": "adenosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.218", "l": "\"tRNA (adenine(9)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222237", "l": "SMYD2 methylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632738", "l": "DDIT4 binds 14-3-3 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046593", "l": "mandelonitrile lyase activity", "d": ["Catalysis of the reaction: mandelonitrile = cyanide + benzaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40129", "l": "a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32645", "l": "17-hydroxylupanine + 2 Fe(II)-[cytochrome c] + 2 H(+) => 2 Fe(III)-[cytochrome c] + H2O + lupanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.213", "l": "\"cytidine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102363", "l": "isoscopoletin-O-methyltransferase activity", "d": ["Catalysis of the reaction: isoscopoletin + S-adenosyl-L-methionine <=> scoparone + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61275", "l": "H2O + L-2-aminopentanoate + O2 <=> 2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449058", "l": "Interleukin-1 family are secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426676", "l": "Formation of laminin networks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41023", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17381", "l": "(9Z,12Z)-octadecadienoate = (9Z,11E)-octadecadienoate", "d": []}, {"i": "EC:5.2.1.5", "l": "\"linoleate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15726", "l": "1,5-anhydro-D-fructose => ascopyrone M + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23185", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate => (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005159", "l": "insulin-like growth factor receptor binding", "d": ["Binding to an insulin-like growth factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37564", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75475", "l": "D-mannose(out) + n Na(+)(out) = D-mannose(in) + n Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53968", "l": "apo-[BtrI ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429101", "l": "HMIT co-transports myo-inositol with a proton (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.6", "l": "\"tubulin GTPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9769235", "l": "MAGED1 binds NPAS4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18237", "l": "2,5-dihydroxybenzoate + O2 = 3-maleylpyruvate + H(+)", "d": []}, {"i": "EC:1.13.11.4", "l": "\"gentisate 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814555", "l": "Integrator complex processes the 3' end of snRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168888", "l": "Alpha1-Microglobulin binds heme (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46843", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801195", "l": "STEAP3 binds BNIP3L (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.9", "l": "\"(R)-2-haloacid dehalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31082", "l": "3-hydroxyisovaleryl-CoA <=> 3-methyl-(2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-874087", "l": "SGT1 binds HSP90 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50293", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26556", "l": "angiotensin-(1-7) + L-phenylalanine => angiotensin II + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35305", "l": "3-oxoisopentadecanoyl-CoA + H(+) + NADPH => 3-hydroxyisopentadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73089", "l": "AMP(in) + FAD(out) => AMP(out) + FAD(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874082", "l": "MET phosphorylates PTK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40242", "l": "ATP + CoA + dodecanedioate <=> AMP + diphosphate + dodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000112", "l": "CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21585", "l": "NAD(+) + propane-1,2-diol 1-phosphate => H(+) + hydroxyacetone phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48069", "l": "ganglioside GM2 (d18:1(4E)) + H2O => ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36594", "l": "(S)-2-chloropropanoate + NADP(+) <=> 2-chloroacrylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008742", "l": "L-ribulose-phosphate 4-epimerase activity", "d": ["Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102525", "l": "2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity", "d": ["Catalysis of the reaction: L-argininium(1+) + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-arginine(1+) + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27843", "l": "9H-carbazole + H(+) + NADPH + O2 => 2'-aminobiphenyl-2,3-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905054", "l": "calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium ion concentration", "d": ["Any calcium-induced calcium release activity that is involved in regulation of presynaptic cytosolic calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12926", "l": "D-erythrose 4-phosphate + L-lysyl-[protein] => H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28164", "l": "CMP + GDP + H(+) => cytidine + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70225", "l": "2-oxobutanoate + L-glutamate => (2S)-2-aminobutanoate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1297444", "l": "Binding of cAMP to HCN channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390930", "l": "5-HT2 receptor can bind serotonin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57648", "l": "S-adenosyl-L-methionine + trichosetin = equisetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52668", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.106", "l": "\"[amino-group carrier protein]-5-phospho-L-glutamate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983150", "l": "Proteasomal cleavage of substrate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664268", "l": "Opsonized leishmania amastigote binds FCGR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626549", "l": "IQGAPs bind CALM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48766", "l": "3-acetyl-3-devinylchlorophyllide a + H(+) + NADH => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22587", "l": "2 H(+) + heme b <=> Fe(2+) + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050189", "l": "phosphoenolpyruvate phosphatase activity", "d": ["Catalysis of the reaction: H2O + phosphoenolpyruvate = phosphate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198611", "l": "AKT phosphorylates IKKalpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71383", "l": "L-asparagine(in) + Na(+)(in) = L-asparagine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51045", "l": "indole-3-pyruvate imine dimer => CO2 + NH4(+) + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424485", "l": "Release of p-PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473184", "l": "Follistatin (FST) binds Activin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102047", "l": "indole-3-acetyl-glycine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + glycine + ATP(4-) <=> H+ + indole-3-acetyl-glycine + AMP(2-) + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9615249", "l": "ARBs bind AGRT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018489", "l": "vanillate monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + vanillate = 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46284", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34603", "l": "15-methylhexadecasphinganine + a fatty acyl-CoA = CoA + H(+) + N-acyl-15-methylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41872", "l": "3-oxododecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydodecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954179", "l": "S100B gene expression is inhibited by ERBB4:TAB2:NCOR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39749", "l": "cholesterol(out) => cholesterol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419426", "l": "Cannabinoid receptors can bind cannabinoids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10103", "l": "a sterol ester + H2O <=> a fatty acid + a sterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029268", "l": "Phosphorylation and activation of PLCG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791319", "l": "NID1 degradation by MMP19 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211219", "l": "Translocation of caspase-3 to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75289", "l": "glyoxylate(out) + sulfate(in) => glyoxylate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67779", "l": "a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H2O <=> a 5'-end dephospho-2'-deoxyribonucleoside-DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070694", "l": "deoxyribonucleoside 5'-monophosphate N-glycosidase activity", "d": ["Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base."]}, {"i": "REACT:R-HSA-8953339", "l": "DNPH1 hydrolyses dGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605768", "l": "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0070717", "l": "poly-purine tract binding", "d": ["Binding to a stretch of purines (adenine or guanine) in an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735439", "l": "Expression of MYOCD in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51735", "l": "glandicoline B + S-adenosyl-L-methionine <=> H(+) + meleagrin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388560", "l": "EDNRA,EDNRB bind EDNs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55485", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57256", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP = GTP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66426", "l": "ADP + H(+) + leukotriene B4(out) + phosphate => ATP + H2O + leukotriene B4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696274", "l": "RND1 binds GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50251", "l": "ATP + D-ribose 5-phosphate + H(+) <=> ADP-D-ribose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44675", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O <=> a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322431", "l": "XIAP binds TLE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15904", "l": "(2R)-2-phosphoglycerate <=> (2R)-3-phosphoglycerate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.33", "l": "\"N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112385", "l": "Addition of nucleotides leads to transcript elongation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.61", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12063", "l": "acetyl-CoA + 5 H(+) + 6 malonyl-CoA <=> 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9692539", "l": "HRH1 binds HRH1 inverse agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806831", "l": "CYB5Rs reduce MetHb to HbA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67853", "l": "FMNH2 + O2 => FMN-N(5)-peroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71956", "l": "glutarate(out) + 3 Na(+)(out) => glutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21612", "l": "D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13852", "l": "D-arabinose <=> D-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103083", "l": "methylthiobutylmalate isomerase activity", "d": ["Catalysis of the reaction: 2-(4'-methylthio)butylmalate <=> 3-(4'-methylthio)butylmalate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18968", "l": "hydroxymethylbilane <=> H2O + uroporphyrinogen III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70875", "l": "L-glutamine(in) + L-methionine(out) + Na(+)(out) = L-glutamine(out) + L-methionine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876789", "l": "CARNMT1 methylates CARN to Anserine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034953", "l": "perillyl-CoA hydratase activity", "d": ["Catalysis of the reaction: perillyl-CoA + H2O = 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39516", "l": "(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH => (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41547", "l": "8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870461", "l": "RABGGTA and RABGGTB bind (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29067", "l": "formate + H(+) + menaquinone-8 = CO2 + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23595", "l": "glycerol + NADP(+) <=> D-glyceraldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033708", "l": "isocitrate-homoisocitrate dehydrogenase activity", "d": ["Catalysis of the reactions: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH, and (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25394", "l": "(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) <=> cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69925", "l": "brassinolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => castasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66684", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] = L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905108", "l": "guanosine binding", "d": ["Binding to guanosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32613", "l": "(6E)-8-oxogeranial + H(+) + NADPH => (6E)-8-hydroxygeranial + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22268", "l": "ATP + streptomycin = ADP + H(+) + streptomycin 6-phosphate", "d": []}, {"i": "EC:2.7.1.72", "l": "\"streptomycin 6-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.108", "l": "\"2,5-diketocamphane 1,2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784204", "l": "JAKs bind OSMR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45409", "l": "(2E)-dodecenoyl-CoA + H(+) + NADH => dodecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35878", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67082", "l": "a very long-chain fatty acid(out) + ADP + H(+) + phosphate => a very long-chain fatty acid(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030766", "l": "11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31522", "l": "O2 + torulene <=> 3-methyl-2-butenal + 4'-apo-beta-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75150", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (-)-cyatha-3,12-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59524", "l": "9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] = 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30320", "l": "H(+) + NADH + O2 + theobromine => 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669250", "l": "PAK1 phosphorylates FLNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801109", "l": "CHM binds RGGT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043873", "l": "pyruvate-flavodoxin oxidoreductase activity", "d": ["Catalysis of the reaction: pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68821", "l": "(2Z,6E)-farnesyl diphosphate + H2O => (6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473584", "l": "Collagen type III degradation by MMP15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28604", "l": "(1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004150", "l": "dihydroneopterin aldolase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114284", "l": "Release of Cytochrome c from mitochondria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8934742", "l": "RUNX1 binds PRMT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43641", "l": "dodecanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxotetradecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27547", "l": "anthranilate + FADH2 + O2 => 3-hydroxyanthranilate + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48569", "l": "3-chlorocatechol + O2 => (2E,4Z)-2-chloromuconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5444523", "l": "Formation of MSH1:PMS2 Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66195", "l": "ATP + bilirubin-bisglucuronoside(in) + H2O <=> ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55034", "l": "an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N-methylornithine lipid + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797803", "l": "PTPRD binds SLITRK1-6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875591", "l": "DOCK7 activates RAC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57414", "l": "ATP + H(+) + L-tyrosine + NADPH => AMP + diphosphate + L-tyrosinal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937682", "l": "RUNX1 binds SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69236", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate = 4-hydroxybutylnitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56688", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate", "d": []}, {"i": "EC:1.14.20.9", "l": "\"tyrosine isonitrile desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888577", "l": "Synthesis of GABA by GAD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46104", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = corticosterone + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68914", "l": "DNA polymerase alpha:primase binds at the origin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9035484", "l": "CysS248-MPST:TXN2 dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48316", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b = a ganglioside GD1alpha + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085992", "l": "SUMOylation of DAXX with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73234", "l": "2,4,6-trichlorophenol + FADH2 + O2 <=> 2-chloro-6-hydroxy-1,4-benzoquinone + 2 chloride + FAD + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58746", "l": "diphosphate + H(+) + N(7)-methyl-GMP => H2O + N(7)-methyl-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.535054500181104", "identifiers": [{"i": "GO:0016623", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen."]}, {"i": "EC:1.2.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604722", "l": "Activation of proMMP9 by proteases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592297", "l": "Full activation of MMP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49630", "l": "3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine => acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43514", "l": "2-carboxy-5-formylfuran + H(+) + H2O2 => 2-(dihydroxymethyl)-5-formylfuran + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70410", "l": "[(2E,6E,10E)-geranylgeranyl]-L-cysteine + H2O + O2 <=> (2E,6E,10E)-geranylgeranial + H2O2 + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18179", "l": "a (2E)-enoyl-CoA + H(+) + NADH => a 2,3-saturated acyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944223", "l": "Association of procollagen type V (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390595", "l": "Calcium Binds Troponin-C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.594043123901756", "identifiers": [{"i": "GO:0097472", "l": "cyclin-dependent protein kinase activity", "d": ["Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66626", "l": "(25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606162", "l": "Phosphorylated BTK phosphorylates PLCG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48959", "l": "[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide <=> [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28225", "l": "3-dehydro-L-gulonate + ATP <=> 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12987", "l": "GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465940", "l": "atRAL is reduced to atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19829", "l": "a primary alcohol + O2 = an aldehyde + H2O2", "d": []}, {"i": "EC:1.1.3.13", "l": "\"alcohol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34579", "l": "2 2-oxoglutarate + 2 O2 + pentalenolactone D = 2 CO2 + H2O + pentalenolactone F + 2 succinate", "d": []}, {"i": "EC:1.14.11.36", "l": "\"pentalenolactone F synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102069", "l": "zerumbone synthase activity", "d": ["Catalysis of the reaction: 8-hydroxy-alpha-humulene + NAD <=> zerumbone + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50413", "l": "L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] => H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43434", "l": "butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) => butan-1-ol + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34312", "l": "4-nitrocatechol + NADH + O2 => 2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10147", "l": "a ribonucleoside 3'-phosphate + H2O <=> a ribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449077", "l": "Interleukin-16 is secreted (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43058", "l": "10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+) => 5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047571", "l": "3-oxosteroid 1-dehydrogenase activity", "d": ["Catalysis of the reaction: a 3-oxosteroid + acceptor = a 3-oxo-D1-steroid + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170810", "l": "nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12426", "l": "NH4(+) + oxaloacetate => (3S)-3-hydroxy-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53093", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450533", "l": "PKCdelta phosphorylates HuR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013895", "l": "Caspase-8 processing within TLR3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21306", "l": "ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31596", "l": "(Z)-2-methylureidoacrylate + H2O => (Z)-2-methylaminoacrylate + carbamate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16688", "l": "di-trans,poly-cis-dolichol + hexadecanoyl-CoA <=> a dolichyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391377", "l": "Luteinizing hormone receptor can bind LH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70950", "l": "L-tryptophan(in) <=> L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13413", "l": "ADP + thymidine = AMP + dTMP + H(+)", "d": []}, {"i": "EC:2.7.1.118", "l": "\"ADP--thymidine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42866", "l": "H(+) + norspermine + S-methyl-5'-thioadenosine => norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805811", "l": "Release of SEPT4 from mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696958", "l": "USP44 deubiquitinates CDC20 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54734", "l": "H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607740", "l": "PKC-delta phosphorylates CARD9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50046", "l": "adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+) => an acyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955844", "l": "RBKS phosphorylates ribose to R5P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-996727", "l": "REST recruits the BHC complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18495", "l": "CoA + H(+) + N-benzoylglycine => benzoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209823", "l": "Tyrosine is hydroxylated to dopa (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483197", "l": "PTPMT1 dephosphorylates PGP to PG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102648", "l": "D-ribose 5-phosphate:D-fructose 6-phosphate transaldolase activity", "d": ["Catalysis of the reaction: D-fructose 6-phosphate + D-ribose 5-phosphate <=> D-glycero-D-altro-octulose 8-phosphate + D-glyceraldehyde 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73382", "l": "(R)-lipoate(out) + 2 Na(+)(out) <=> (R)-lipoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446209", "l": "Transfer of N-glycan to the protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46988", "l": "(R)-6-hydroxynicotine + O2 = 6-hydroxy-N-methylmyosmine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51829", "l": "ATP(in) + CoA(in) + docosanoate(out) + H(+)(out) => AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109862", "l": "MAP2K2 phosphorylates MAPK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15842", "l": "D-glucose 6-phosphate + NADP(+) => 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047188", "l": "aromatic-hydroxylamine O-acetyltransferase activity", "d": ["Catalysis of the reaction: N-hydroxy-4-aminobiphenyl + N-hydroxy-4-acetylaminonbiphenyl = N-acetoxy-4-aminobiphenyl + N-hydroxy-4-aminobiphenyl."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220613", "l": "EGF-induced dimerization of ligand-responsive EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20548", "l": "H(+) + L-kynurenine + NADPH + O2 <=> 3-hydroxy-L-kynurenine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420206", "l": "Phosphorylation of SRC-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204779", "l": "Interaction of Tie2 with Ang1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16648", "l": "H2O + hexadecanoyl-CoA <=> CoA + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11133", "l": "chlorophyllide a + NADP(+) => H(+) + NADPH + protochlorophyllide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33592", "l": "sphinganine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53475", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18064", "l": "5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran <=> methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11947", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O <=> 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035527", "l": "3-hydroxypropionate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047843", "l": "dehydrogluconate dehydrogenase activity", "d": ["Catalysis of the reaction: 2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682769", "l": "LGI2 binds ADAM22,23 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21418", "l": "dihydroxyacetone phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613460", "l": "ID1 and ID3 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67149", "l": "L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2 => 2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65559", "l": "globoside GalGb4Cer + H2O <=> an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18592", "l": "[glutamine synthetase]-L-tyrosine + ATP <=> [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58487", "l": "H2O + N-(acetyl)-sphing-4-enine <=> acetate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45374", "l": "(9Z)-octadecenoate + sphinganine => H2O + N-(9Z-octadecenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54084", "l": "7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine = archaeosine(15) in tRNA + L-glutamate", "d": []}, {"i": "EC:2.6.1.97", "l": "\"archaeosine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50416", "l": "L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350443", "l": "PP1-87B:MBS complex dephosphorylates SQH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72806", "l": "L-arginine(out) + N(omega)-methyl-L-arginine(in) <=> L-arginine(in) + N(omega)-methyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39459", "l": "(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692749", "l": "CDC14A,B bind MAPK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14590", "l": "luteolin + S-adenosyl-L-methionine => chrysoeriol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332359", "l": "Active calmodulin binds CAMK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210282", "l": "Interaction of GPVI and FceRI gamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.315", "l": "\"11-cis-retinol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71143", "l": "3-hydroxyhispidin + O2 = (E)-caffeoylpyruvate + CO2 + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58129", "l": "A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine => AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75202", "l": "H2O + triuret <=> 1-carboxybiuret + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61729", "l": "a 3-dehydro-D-guloside => a 3-dehydro-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694462", "l": "ABHD6,12 hydrolyse 3AG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40344", "l": "3-oxohexadecanedioyl-CoA + CoA => acetyl-CoA + tetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442387", "l": "ZIP8 mediates zinc influx into cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45228", "l": "a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36054", "l": "beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O <=> 2 beta-L-arabinofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686587", "l": "ABL1 phosphorylates RAD52 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019001", "l": "guanyl nucleotide binding", "d": ["Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate."]}, {"i": "REACT:R-HSA-156909", "l": "eEF1A complexes with GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801166", "l": "TP53 binds the STEAP3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33809", "l": "2-methoxy-4-vinylphenol + CO2 => (E)-ferulate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0045499", "l": "chemorepellent activity", "d": ["Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222128", "l": "NOC2L binds TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39410", "l": "3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29591", "l": "2-hydroxyethane-1-sulfonate + NADP(+) = H(+) + NADPH + sulfoacetaldehyde", "d": []}, {"i": "EC:1.1.1.313", "l": "\"sulfoacetaldehyde reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46110", "l": "(2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+) => (2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72638", "l": "1-hydroxy-6-methoxyphenazine N(10)-oxide + S-adenosyl-L-methionine <=> 1,6-dimethoxyphenazine N(5)-oxide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51901", "l": "H2O + N(1)-acetylspermidine => acetate + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.24", "l": "\"diphosphoinositol-pentakisphosphate 1-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944257", "l": "Association of procollagen type XXIV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19554", "l": "H2O + L-tryptophan => indole + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51107", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938231", "l": "RUNX1:CBFB binds CREBBP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003877", "l": "ATP adenylyltransferase activity", "d": ["Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18876", "l": "3-chloro-D-alanine + H2O <=> chloride + H(+) + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42131", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013435", "l": "RHOD auto-activates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20356", "l": "A + chloride + H(+) + trichloroethene <=> AH2 + tetrachloroethene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63613", "l": "prunetin + UDP-alpha-D-glucuronate => prunetin-5-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42241", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA => 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682377", "l": "LC3 de-lipidation by ATG4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168412", "l": "MDP elicits a NOD2 response (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617829", "l": "Assembly of IFT A complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72738", "l": "UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) <=> UDP-N-acetyl-alpha-D-galactosamine(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38034", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) <=> (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351208", "l": "Spermidine  => N-acetylated spermidine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41798", "l": "a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5138459", "l": "WNT5A:FZD4 is endocytosed (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873850", "l": "STARD5 binds DCA, LCA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507875", "l": "Aquaporins passively transport urea into cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14949", "l": "A + H2O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2", "d": []}, {"i": "EC:1.3.99.19", "l": "\"quinoline-4-carboxylate 2-oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624668", "l": "CEBPA binds CDKN1A (p21) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251559", "l": "Deletions of the AMER1 gene prevent expression of AMER1 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30581", "l": "L-threonine + phosphate => H2O + O-phospho-L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73188", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate => (2R,3S,11R)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863472", "l": "DAB2 binds LRP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55764", "l": "1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27859", "l": "2',3'-cyclophospho-GMP + H2O => 3'-GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15699", "l": "2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase] => (2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25810", "l": "3-aminopropanal + H2O2 + putrescine => H2O + O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74989", "l": "erythrostominone(out) => erythrostominone(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21987", "l": "3'-phosphoadenylyl sulfate + choline <=> adenosine 3',5'-bisphosphate + choline sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21251", "l": "a ribonucleoside 5'-triphosphate + RNA(n) <=> diphosphate + RNA(n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18669", "l": "adenosine + H2O = adenine + D-ribose", "d": []}, {"i": "EC:3.2.2.7", "l": "\"adenosine nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18496", "l": "benzoyl-CoA + glycine <=> CoA + H(+) + N-benzoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391935", "l": "DP1 receptor can bind PGD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21598", "l": "2-aminomalonate semialdehyde + H(+) + NADPH => L-serine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39221", "l": "(3R)-hydroxyoctacosanoyl-CoA + NADP(+) => 3-oxooctacosanyol-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41207", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35441", "l": "archaetidylserine + CMP + H(+) => CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54225", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphocholine => 2-(prostaglandin E2)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67619", "l": "8-oxo-GTP + H2O <=> 8-oxo-GMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102094", "l": "S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a demethylmenaquinol <=> S-adenosyl-L-homocysteine + H+ + a menaquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75439", "l": "eburicol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 14-demethyleburicol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009670", "l": "triose-phosphate:phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: triose-phosphate(out) + phosphate(in) = triose-phosphate(in) + phosphate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52486", "l": "(3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2 => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11265", "l": "H(+) + NADH + O2 => H2O2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950718", "l": "Expression of TCP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9671145", "l": "DKC1 binds SHQ1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28571", "l": "ATP + L-serine => diphosphate + L-seryl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19842", "l": "H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63627", "l": "hexadecanoyl-AMP + holo-[ACP] <=> AMP + H(+) + hexadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55863", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47980", "l": "dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940001", "l": "RUNX2:CBFB binds the MMP13 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177923", "l": "Sustained activation of SRC kinase by SHP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13573", "l": "[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate = [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.43", "l": "\"polygalacturonate 4-alpha-galacturonosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16733", "l": "H(+) + orsellinate = CO2 + orcinol", "d": []}, {"i": "EC:4.1.1.58", "l": "\"orsellinate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28149", "l": "geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37500", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42745", "l": "guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006870", "l": "IL21 receptor STAT phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592246", "l": "Expression of TFAM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56850", "l": "H(+) + reumycin + S-adenosyl-L-homocysteine => 1,6-didemethyltoxoflavin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0051998", "l": "protein carboxyl O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to a carboxyl group on a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007447", "l": "E2F6 forms the PRC1L4 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22691", "l": "D-alanine + H2O + O2 <=> H2O2 + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0034386", "l": "4-aminobutyrate:2-oxoglutarate transaminase activity", "d": ["Catalysis of the reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34713", "l": "15-methylhexadecasphing-4-enine + a fatty acid => H2O + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620004", "l": "RSKs autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507869", "l": "Aquaporins passively transport glycerol into cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12842", "l": "pyridoxamine + pyruvate => L-alanine + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110506", "l": "Activated DTOR phosphorylates DS6K (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53095", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0030613", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}, {"i": "EC:1.20.-.-", "l": "\"Acting on phosphorus or arsenic in donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047546", "l": "2-hydroxypyridine 5-monooxygenase activity", "d": ["Catalysis of the reaction: 2-hydroxypyridine + AH(2) + O2 = 2,5-dihydroxypyridine + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58584", "l": "dihydroprecondylocarpine acetate = (-)-tabersonine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113402", "l": "Formation of DSIF:NELF:early elongation complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.26", "l": "\"cancer procoagulant\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50430", "l": "dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine => methanethiol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788867", "l": "FN3K phosphorylates ketosamines (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67935", "l": "ATP + desmosterol(in) + H2O <=> ADP + desmosterol(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858491", "l": "WNTs bind the FZD receptor to initiate PCP pathway (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17341", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70920", "l": "chloride(out) + dopamine(out) + Na(+)(out) => chloride(in) + dopamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41493", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18576", "l": "dihydrochelirubine + H(+) + O2 <=> chelirubine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050064", "l": "luteolin 7-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: luteolin + UDP-alpha-D-glucuronate = luteolin 7-O-beta-D-glucosiduronate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734730", "l": "ORC1 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811427", "l": "COPI vesicle uncoating at the ER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32218", "l": "(6R)-NADHX <=> (6S)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46893", "l": "2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate => 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690702", "l": "LYN phosphorylates CD22 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49586", "l": "L-erythrulose 1-phosphate => D-erythrulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40450", "l": "(2R)-pristanoyl-CoA <=> (2S)-pristanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27275", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683792", "l": "p-T68-CHEK2 autophosphorylates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38379", "l": "(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202216", "l": "Phosphorylation of SLP-76 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9604308", "l": "NICD4 traffics to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509827", "l": "ITPA hydrolyses ITP to IMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69372", "l": "2-hydroxyhexanoate + O2 = 2-oxohexanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391913", "l": "FPR2 binds FPR2 ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048244", "l": "phytanoyl-CoA dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + O2 + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO2 + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634850", "l": "NPAS4 binds ARNT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45162", "l": "acetaldehyde + CO2 => 3-oxopropanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58828", "l": "(9S,10R)-epoxy-octadecanoate + H2O = 9R,10R-dihydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693012", "l": "TNFSF15 binds TNFRSF25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51761", "l": "a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61282", "l": "H2O2 + NH4(+) + succinate semialdehyde => 4-aminobutanoate + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75435", "l": "32-oxoeburicol + O2 + reduced [NADPH--hemoprotein reductase] = 14-demethyleburicol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.194", "l": "\"ginsenosidase type IV\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679266", "l": "Beclin-1 complex translocates to the ER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38822", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879907", "l": "Tyrosine kinases phosphorylate the receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.173", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59243", "l": "L-arginine + L-lysine <=> L-homoarginine + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043915", "l": "L-seryl-tRNA(Sec) kinase activity", "d": ["Catalysis of the reaction: ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60312", "l": "L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848316", "l": "IL36 binds IL1RL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948136", "l": "ULK1 Translocates to the mitochondria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46801", "l": "H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31330", "l": "1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol <=> bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912790", "l": "CBL binds CRK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75525", "l": "CoA + H(+) + N-acetyl-S-methyl-L-cysteine => acetyl-CoA + S-methyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373717", "l": "DCC interacts with DIP13alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22263", "l": "H2O + triacetate lactone <=> H(+) + triacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749590", "l": "ASA- acetylates ALB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102467", "l": "scutellarein 7-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate + scutellarein <=> UDP( + scutellarin + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73656", "l": "(S)-nicotine + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 2 H(+) + N-methylmyosmine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015056", "l": "corticotrophin-releasing factor receptor activity", "d": ["Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38522", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987120", "l": "JAK1 binds IFNLR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202248", "l": "Phosphorylation of PLC-gamma1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047234", "l": "raffinose-raffinose alpha-galactotransferase activity", "d": ["Catalysis of the reaction: 2 raffinose = sucrose + 1F-alpha-D-galactosylraffinose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59602", "l": "5-methoxyindoleacetaldehyde + H2O2 + NH4(+) => 5-methoxytryptamine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19685", "l": "(E)-feruloyl-CoA + tyramine = CoA + H(+) + N-[(E)-feruloyl]tyramine", "d": []}, {"i": "EC:2.3.1.110", "l": "\"tyramine N-feruloyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29490", "l": "(2E,6E)-farnesyl diphosphate <=> cis-muurola-3,5-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19509", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 2 H(+) + L-erythro-biopterin + 2 NADPH", "d": []}, {"i": "EC:1.5.1.33", "l": "\"pteridine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102972", "l": "gibberellin A12,2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A110-forming)", "d": ["Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 = gibberellin A110 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59334", "l": "1'-hydroxytorulene + AH2 => 1'-hydroxy-gamma-carotene + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28509", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP <=> 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29318", "l": "alpha-D-galactose 1-phosphate + H2O <=> D-galactose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63926", "l": "ADP + H(+) + N(4)-acetylcytidine 5'-phosphate => ATP + N(4)-acetylcytidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033713", "l": "choline:oxygen 1-oxidoreductase activity", "d": ["Catalysis of the reaction: choline + O2 = betaine aldehyde + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0015668", "l": "type III site-specific deoxyribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA to give double-stranded fragments with terminal 5'-phosphates. ATP hydrolysis is required. Cleavage is dependent on the presence of two copies of a specific recognition sequence in an inverse orientation in the DNA. Cleavage occurs at a specific distance from one of the recognition sites."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69751", "l": "benzylmalonyl-CoA + H(+) + O2 = (E)-cinnamoyl-CoA + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68163", "l": "N-geranyl-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(8'-hydroxygeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8981892", "l": "Active G alpha (z) binds RGS proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16379", "l": "biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0016002", "l": "sulfite reductase activity", "d": ["Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74987", "l": "TTF-I binds to the Sal Box (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6804266", "l": "CHEK2 phosphorylates TTC5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39308", "l": "(2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH => (11Z,14Z)-eicosadienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167191", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55218", "l": "diphosphate + rhizathalene A => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140312", "l": "cargo adaptor activity", "d": ["Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12717", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.140", "l": "\"inositol-tetrakisphosphate 5-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26023", "l": "8'-apo-beta-carotenol + O2 = (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal", "d": []}, {"i": "EC:1.13.11.67", "l": "\"8'-apo-beta-carotenoid 14',13'-cleaving dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22968", "l": "butanal + CoA + NAD(+) = butanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14884", "l": "3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+) <=> asparagusate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63682", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+) => (7R,8S)-7,8-diammoniononanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5490230", "l": "AFXBO-SG, AFNBO-SG translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160915", "l": "Receptor-mediated uptake of HA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66640", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + koraiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168929", "l": "Viral dsRNA:TLR3 recruits TRIF (TICAM1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25350", "l": "D-tyrosyl-tRNA(Tyr) + H2O <=> D-tyrosine + tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32330", "l": "10-hydroxy-alpha-humulene + NAD(+) <=> H(+) + NADH + zerumbone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.523519163150823", "identifiers": [{"i": "GO:0060090", "l": "molecular adaptor activity", "d": ["The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821366", "l": "AKAP8L binds MLL2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46049", "l": "D-galactosamine 6-phosphate => alpha-D-galactosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202960", "l": "Caspase mediated cleavage of C-IAP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392064", "l": "G alpha (z) inhibits adenylate cyclase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46414", "l": "a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46673", "l": "aldosterone + H(+) + NADPH => 5beta-dihydroaldosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54482", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12684", "l": "creatinine + H(+) + H2O <=> N-methylhydantoin + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018112", "l": "proline racemase activity", "d": ["Catalysis of the reaction: L-proline = D-proline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983061", "l": "TSLP binds CRLF2:IL7R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35037", "l": "4-aminobutanoate(out) => 4-aminobutanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168849", "l": "tBID binds to inactive BAX protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034893", "l": "N-nitrodimethylamine hydroxylase activity", "d": ["Catalysis of the reaction: N-nitrodimethylamine + O2 + 2 H+ + 2 e- = N-nitromethylamine + formaldehyde + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714483", "l": "RAC2 translocates to the ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40246", "l": "(3R)-hydroxyhexadecanoyl-CoA + NAD(+) <=> 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54631", "l": "2-oxoglutarate + dodecanoyl-CoA + O2 <=> 2-hydroxydodecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806613", "l": "Keratin tetramers bind to form unit length filaments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392133", "l": "G alpha (z) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020249", "l": "Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59231", "l": "6-sulfo-alpha-D-quinovose <=> 6-sulfo-beta-D-quinovose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37712", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41965", "l": "butanoyl-CoA + O2 => (2E)-butenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25580", "l": "alpha-L-fucose = beta-L-fucose", "d": []}, {"i": "EC:5.1.3.29", "l": "\"L-fucose mutarotase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.6", "l": "\"nucleoside-diphosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39853", "l": "a 1,2-diacyl-sn-glycerol + glycerol => 2 a 1-acyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13190", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O => 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015134", "l": "hexuronate transmembrane transporter activity", "d": ["Enables the transfer of hexuronates from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55921", "l": "[cis-1,4-isoprene](n) + O2 => (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71783", "l": "3-methyl-2-oxobutanoate(out) + H(+)(out) = 3-methyl-2-oxobutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668545", "l": "NIK autophosphorylates on T559 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55258", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23634", "l": "2-oxoglutarate + CO2 + NADH => D-threo-isocitrate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36789", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37389", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22873", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 => CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39892", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine => dTDP + H(+) + vancomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424476", "l": "Activation of RAC1 by VAV2/3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202394", "l": "Translocation of CARMA1 to Plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23282", "l": "CoA + S-acetylcysteamine => acetyl-CoA + cysteamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54622", "l": "2-hydroxyeicosanoyl-CoA + CO2 + succinate => 2-oxoglutarate + eicosanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30328", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13348", "l": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] <=> diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58569", "l": "15alpha-stemmadenine + acetyl-CoA => CoA + O-acetyl-15alpha-stemmadenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74986", "l": "Elongation of pre-rRNA transcript (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60668", "l": "(R,R)-chrysanthemol + NAD(+) = (1R,3R)-chrysanthemal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875451", "l": "MET phosphorylates CBL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380949", "l": "AMPK is dephosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50930", "l": "(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0071949", "l": "FAD binding", "d": ["Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39507", "l": "3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27297", "l": "D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35329", "l": "3-oxodocosanoyl-CoA + CO2 + CoA => eicosanoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46047", "l": "(3Z)-octenoyl-CoA <=> (2E)-octenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58460", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine = a monoacyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625092", "l": "ABCA6 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67412", "l": "alpha-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21444", "l": "3-(2-hydroxyphenyl)propanoate + NAD(+) = H(+) + NADH + trans-2-coumarate", "d": []}, {"i": "EC:1.3.1.11", "l": "\"2-coumarate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874078", "l": "PTK2 autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0042799", "l": "histone H4K20 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group to the lysine residue at position 20 of the histone H4 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374681", "l": "L1 and NCAM1 engaged in cis-interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196929", "l": "FLAD1 phosphorylates FMN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23393", "l": "(n-1) H2O + RNA(n) => n a ribonucleoside 5'-phosphate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866269", "l": "ARRB bind GPCRs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375151", "l": "Interaction of NCAM1 with collagens (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046180", "l": "KSPG is secreted from the cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417927", "l": "P2Y2 receptor binds ATP and UTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35947", "l": "dihydrochanoclavine-I aldehyde + NADP(+) = chanoclavine-I aldehyde + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.100", "l": "\"chanoclavine-I aldehyde reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20949", "l": "3-sulfopyruvate + H(+) => CO2 + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2172678", "l": "PHF8 demethylates histone H4K20me1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450348", "l": "Activated human JNKs migrate to nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29699", "l": "dimethyl sulfoxide(in) = dimethyl sulfoxide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683774", "l": "p-T68-CHEK2 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47957", "l": "3-maleylpyruvate + H2O => H(+) + maleate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686088", "l": "CASP3 cleaves GSDMD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55259", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685608", "l": "CLEC2B binds KLRF1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68108", "l": "L-glucitol + NAD(+) = H(+) + keto-L-fructose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66145", "l": "5-methoxytryptamine + acetyl-CoA => CoA + H(+) + melatonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31870", "l": "(S)-2,3-epoxysqualene <=> baccharis oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19480", "l": "4-hydroxybenzoate + H(+) + NADPH + O2 <=> 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22274", "l": "(20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51764", "l": "dimethylallyl diphosphate + phlorisovalerophenone = 4-prenylphlorisovalerophenone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32487", "l": "CDP-choline + H2O = CMP + 2 H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977301", "l": "Histidine is decarboxylated to histamine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009817", "l": "Acitretin binds to RAR:RXR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28925", "l": "H(+)(out) + L-phenylalanine(out) => H(+)(in) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16969", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose", "d": []}, {"i": "EC:5.1.3.13", "l": "\"dTDP-4-dehydrorhamnose 3,5-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784959", "l": "BPHL hydrolyses VACV to ACV (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014294", "l": "RAC2 binds effectors at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28348", "l": "7,8-dihydromonapterin 3'-triphosphate => 7,8-dihydroneopterin 3'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40739", "l": "(20S)-ginsenoside Rb2 + 2 H2O = (20S)-ginsenoside C-Y + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59879", "l": "(indol-3-yl)butanoate + ATP + L-cysteine <=> (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617862", "l": "Retinoic acid activates HOXA4 chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592316", "l": "Initial activation of proMMP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3149519", "l": "MMACHC decyanates CNCbl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18499", "l": "L-xylulose 5-phosphate => L-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13950", "l": "H(+) + NADP(+) + 2 reduced [rubredoxin] => NADPH + 2 oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54089", "l": "3,4-dihydroxyphenylacetate + H(+) + NADH + O2 => 2,4,5-trihydroxyphenylacetate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21672", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.100", "l": "\"protein-S-isoprenylcysteine O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981728", "l": "Factor H binds to membrane-associated C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202713", "l": "CD84 homodimerises (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730841", "l": "Phosphorylation and activation of VAV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44175", "l": "H2O + NAD(+) + tetradecanal <=> 2 H(+) + NADH + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450031", "l": "Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203553", "l": "eNOS binds NOSIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007522", "l": "E2F6 binds APAF1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43689", "l": "N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate => L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14836", "l": "(R)-mevalonate + CoA + 2 NAD(+) <=> (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21519", "l": "isopiperitenone <=> piperitenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62305", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine => (+)-premalbrancheamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419428", "l": "S1PR2-5 bind S1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382054", "l": "PDGF binds to extracellular matrix proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603784", "l": "PEX19:class I PMP binds PEX3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73241", "l": "H(+) + ladanein + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + scutellarein 7-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47690", "l": "Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH => cis-4-hydroxy-L-proline + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729725", "l": "SARS-CoV-2 nsp3 deISGylates ISGylated IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68838", "l": "(6R,7S)-himachala-9,11-diene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10575", "l": "vinylacetyl-CoA <=> (2E)-butenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098617", "l": "adenylylselenate kinase activity", "d": ["Catalysis of the reaction: ATP + adenylylselenate => ADP + 3'-phosphoadenylylselenate."]}, {"i": "REACT:R-HSA-2408540", "l": "APSe is phosphorylated to PAPSe by PAPSS1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40762", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0008301", "l": "DNA binding, bending", "d": ["The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080041", "l": "ADP-ribose pyrophosphohydrolase activity", "d": ["Catalysis of the reaction: ADP-ribose + H2O = AMP + ribose-1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614816", "l": "Latent Transcriptinally Repressed HCMV Genome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35376", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O => (beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.97", "l": "\"methyltetrahydroprotoberberine 14-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49732", "l": "H(+) + O2 + violaceinate = CO2 + H2O + violacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40387", "l": "1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641147", "l": "DACT1 binds DVL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69568", "l": "(2S)-2-amino-4-deoxychorismate + H2O + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66624", "l": "cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18057", "l": "O2 + Watasenia luciferin = CO2 + hnu + oxidized Watasenia luciferin", "d": []}, {"i": "EC:1.13.12.8", "l": "\"Watasenia-luciferin 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26210", "l": "L-allo-threonine => acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65275", "l": "chrodrimanin C + H(+) + NADPH + O2 <=> chrodrimanin H + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430190", "l": "p-SLP-76 binds NCK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45903", "l": "a (3Z)-enoyl-CoA <=> a 4-saturated (2E)-enoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.53", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69116", "l": "glyoxylate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632671", "l": "CSNK1A1 binds SMO dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694390", "l": "nsp15 binds RB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685953", "l": "SIRT6 deacetylates RBBP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21633", "l": "2 catechol + O2 => 2 1,2-benzoquinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74986", "l": "Elongation of pre-rRNA transcript (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873850", "l": "STARD5 binds DCA, LCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11031", "l": "ATP + D-mannose <=> ADP + D-mannose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607736", "l": "MALT1 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47765", "l": "S-adenosyl-L-methionine + uridine(1369) in 16S rRNA => 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982792", "l": "Growth hormone receptor binds JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689861", "l": "Recruitment of XPA and release of CAK  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15377", "l": "(S)-4,5-dihydroxypentane-2,3-dione + ATP = (2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.189", "l": "\"autoinducer-2 kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69387", "l": "(R)-carnitine + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) <=> (3R)-4-(dimethylamino)-3-hydroxybutanoate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36135", "l": "(2E)-hexadecenal + H2O + NAD(+) = (E)-hexadec-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050412", "l": "cinnamate beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: trans-cinnamate + UDP-D-glucose = 1-O-trans-cinnamoyl-beta-D-glucopyranose + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69173", "l": "Joining of adjacent Okazaki fragments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38353", "l": "3-phenylpyruvate + H(+) + NADH => (R)-3-phenyllactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14175", "l": "4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate => dimethylallyl diphosphate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10486", "l": "(E)-ferulate + glycine => H2O + N-feruloylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11840", "l": "benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.28", "l": "\"benzaldehyde dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28678", "l": "alpha-D-galactose <=> beta-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74131", "l": "malvidin + UDP-alpha-D-galactose = H(+) + malvidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47035", "l": "AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA <=> 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21879", "l": "(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) <=> (S)-usnate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11273", "l": "a (2R)-2-hydroxycarboxylate + a quinone => a 2-oxocarboxylate + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129375", "l": "Elastin cross-linking by lysyl oxidase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46854", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) => 5alpha-cholest-8-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174157", "l": "Degradation of multiubiquitinated Cyclin B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17452", "l": "(2E)-geranyl diphosphate + flaviolin <=> 3-linalylflaviolin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42279", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] <=> (4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71265", "l": "chloride(in) + L-proline(in) + 2 Na(+)(in) => chloride(out) + L-proline(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047787", "l": "delta4-3-oxosteroid 5beta-reductase activity", "d": ["Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67242", "l": "adenosine + H(+) + L-methionine => (R)-S-adenosyl-L-methionine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5681987", "l": "LC3 is cleaved by ATG4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.156", "l": "\"phloroisovalerophenone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656775", "l": "Cysmethynil binds ICMT:Zn2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11531", "l": "2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13029", "l": "H2O + N-acetyl-D-glucosamine + O2 = H(+) + H2O2 + N-acetyl-D-glucosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675206", "l": "PEA15 binds MAPK monomers and dimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202164", "l": "Translocation of PDK1 to Plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9680443", "l": "ROCK1,2 bind ROCKi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20573", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112379", "l": "Recruitment of elongation factors to form elongation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52876", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20315", "l": "1D-myo-inositol hexakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60375", "l": "D-fructose(out) <=> D-fructose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.4.1", "l": "\"protein disulfide-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000252", "l": "C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity", "d": ["Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390674", "l": "ADRB1 bind ADR,NAd (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41446", "l": "glycine + 2 H(+) + phosphate => (1R)-(2-amino-1-hydroxyethyl)phosphonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20307", "l": "4-hydroxybenzoate + 2 H(+) + NADH => 4-hydroxybenzaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18720", "l": "3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0141058", "l": "histone H4 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a modified lysine residue of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23332", "l": "(2R)-3-phosphoglycerate + GTP = (2R)-3-phospho-glyceroyl phosphate + GDP", "d": []}, {"i": "EC:2.7.2.10", "l": "\"phosphoglycerate kinase (GTP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450550", "l": "PKCalpha phosphorylates HuR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052763", "l": "ulvan lyase activity", "d": ["Catalysis of the cleavage of a carbon-oxygen bond in ulvan, a carbohydrate composed of a repeating structure of [->4)-beta-D-GlcA-(1,4)-alpha-L-Rha 3S-(1->4)-alpha-L-IdoA-(1->4)-alpha-L-Rha 3S-(1-]n. Continued digest of ulvan with an enzyme that can catalyze this reaction results in ulvanobiouronic acid A 3-sulfate [->4)-beta-D-GlcpA-(1->4)-alpha-L-Rhap 3-sulfate-(1-]n with 4-deoxy-L-threo-hex-4-enopyranosiduronic acid at the non-reducing end."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950782", "l": "p-STAT1 binds p-STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39125", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA => (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30544", "l": "(S)-carnitine + ATP + CoA => (S)-carnitinyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30793", "l": "dGDP + H(+) + phosphoenolpyruvate => dGTP + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22504", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate", "d": []}, {"i": "EC:2.8.2.26", "l": "\"quercetin-3-sulfate 3'-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035650", "l": "AP-1 adaptor complex binding", "d": ["Binding to an AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75137", "l": "H(+) + NADPH + neopinone => NADP(+) + neopine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73623", "l": "CTP(out) + GDP(in) = CTP(in) + GDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31648", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O => 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49959", "l": "5,10-dihydrophenazine 1-carboxylate + O2 <=> H2O2 + phenazine-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19469", "l": "NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39903", "l": "isoxazolin-5-one + O-acetyl-L-serine = 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+)", "d": []}, {"i": "EC:2.5.1.119", "l": "\"beta-(isoxazolin-5-on-4-yl)-L-alanine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617595", "l": "SGTA binds mislocalized membrane protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38174", "l": "hexadecane-1,2-diol + hexadecanoyl-CoA <=> 2-hydroxyhexadecyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35762", "l": "8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070907", "l": "histidine:histamine antiporter activity", "d": ["Catalysis of the reaction: histidine(out) + histamine(in) = histidine(in) + histamine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27908", "l": "(2E)-butenoyl-CoA + H(+) + NADPH => butanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19546", "l": "H2O + sn-glycerol 3-phosphocholine => glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13782", "l": "an L-alpha-amino acid + H2O + O2 => a 2-oxocarboxylate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.24", "l": "\"biliverdin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157632", "l": "Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42824", "l": "2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 = H2O + 2 NAD(+) + tetracenomycin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805640", "l": "AKT phosphorylates KAT6A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-706479", "l": "TAK1 is activated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58100", "l": "1-(15Z-tetracosenoyl)-glycerol + H2O = (15Z)-tetracosenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682992", "l": "KDM4A,B bind H4K20Me2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37398", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64003", "l": "(4R)-hydroxysphinganine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16213", "l": "3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.224", "l": "\"glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65987", "l": "hnu + previtamin D3 <=> lumisterol 3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43480", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24703", "l": "NAD(+) + UDP-alpha-D-glucuronate => CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.53", "l": "\"calpain-2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21049", "l": "ATP + isopropylamine + L-glutamate => ADP + gamma-L-glutamyl-isopropylamide + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27649", "l": "inosine + phosphate <=> alpha-D-ribose 1-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654510", "l": "FGFRL1 binds SPRED1/2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372977", "l": "succinylCoA + ADP + Pi <=> succinate + CoASH + ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034008", "l": "R-linalool synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + H2O = (R)-linalool + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390673", "l": "CHRM2,4 bind acetylcholine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10868", "l": "a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA", "d": []}, {"i": "EC:2.3.1.20", "l": "\"diacylglycerol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102304", "l": "sesquithujene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> 7-epi-sesquithujene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878702", "l": "p-BMAL1:p-CLOCK,NPAS2 binds KLF15 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.253913141376358", "identifiers": [{"i": "GO:0008175", "l": "tRNA methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63822", "l": "H(+) + holo-[aryl-carrier protein] + petrobactin => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16330", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18359", "l": "H(+) + NADPH + tropinone => NADP(+) + tropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9681294", "l": "IL6R binds IL6R inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73791", "l": "dimethylallyl diphosphate + neoechinulin A = diphosphate + variecolorin G", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102535", "l": "ladanein 6-O-methyltransferase activity", "d": ["Catalysis of the reaction: ladanein + S-adenosyl-L-methionine <=> H+ + salvigenin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38848", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165162", "l": "Phosphorylation of TSC2 by PKB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17724", "l": "a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40772", "l": "(20S)-ginsenoside Rg1 + H2O => (20S)-ginsenoside F1 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30699", "l": "2-oxoglutarate + beta-alanine = 3-oxopropanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.120", "l": "\"beta-alanine--2-oxoglutarate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68961", "l": "7,8-dihydroxycoumarin + S-adenosyl-L-methionine => 7-hydroxy-8-methoxycoumarin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24683", "l": "5,10-methylenetetrahydromethanopterin + NADP(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71092", "l": "dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) => dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66828", "l": "2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25468", "l": "(2E,6E)-farnesyl diphosphate = beta-himachalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9609921", "l": "SGTA binds Tail-anchored protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70060", "l": "a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990756", "l": "ubiquitin ligase-substrate adaptor activity", "d": ["The binding activity of a molecule that brings together a ubiquitin ligase and its substrate. Usually mediated by F-box BTB/POZ domain proteins."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035438", "l": "cyclic-di-GMP binding", "d": ["Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62441", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) => 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32520", "l": "(2E)-geranyl diphosphate + S-adenosyl-L-methionine => (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989750", "l": "Expression of FATP1 (SLC27A1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186773", "l": "PDGF dimer binds two receptors simultaneously (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55499", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26155", "l": "(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil <=> 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047975", "l": "guanosine phosphorylase activity", "d": ["Catalysis of the reaction: guanosine + phosphate = guanine + D-ribose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29800", "l": "ATP + D-allose(out) + H2O => ADP + D-allose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12058", "l": "4-phospho-D-erythronate + 2 H(+) + NADH => D-erythrose 4-phosphate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65601", "l": "4,5,8-trihydroxycasbene + 2 NAD(+) => 2 H(+) + jolkinol C + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168038", "l": "Collagen type XV restin release (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798749", "l": "Exocytosis of specific granule lumen proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68033", "l": "(S)-cystathionine ketimine + 2 H(+) + NADH => (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43797", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56316", "l": "3-amino-4-hydroxybenzoate + acetyl-CoA = 3-acetylamino-4-hydroxybenzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46711", "l": "2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase] <=> AMP + H(+) + salicyl-[non-ribosomal peptide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247497", "l": "ERBB3 binds neuregulins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2423785", "l": "CR:atREs binds apoE and HSPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675431", "l": "PP2A dephosphorylates RAF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031132", "l": "serine 3-dehydrogenase activity", "d": ["Catalysis of the reaction: L-serine + NADP+ = L-alpha-formylglycine + 2 H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11857", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848110", "l": "SOCS3 binds activated PTK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45552", "l": "H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34898", "l": "ATP + H2O + selenite(out) <=> ADP + H(+) + phosphate + selenite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68311", "l": "1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008838", "l": "diaminopropionate ammonia-lyase activity", "d": ["Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672961", "l": "PP2A dephosphorylates inactive RAFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180014", "l": "protein-tRNA adaptor activity", "d": ["The binding activity of a protein that brings together another protein and a tRNA, permitting those molecules to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20792", "l": "ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)", "d": []}, {"i": "EC:6.1.1.6", "l": "\"lysine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17448", "l": "H2 + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44882", "l": "ADP + H(+) + O-phospho-L-threonyl-[receptor-protein] => ATP + L-threonyl-[receptor-protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019168", "l": "2-octaprenylphenol hydroxylase activity", "d": ["Catalysis of the reaction: 2-octaprenylphenol + NADPH + O2 + H+ = 2-octaprenyl-6-hydroxyphenol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13178", "l": "6-phospho-5-dehydro-2-deoxy-D-gluconate => 3-oxopropanoate + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0042826", "l": "histone deacetylase binding", "d": ["Binding to histone deacetylase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730904", "l": "Auto-ubiquitination of TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74587", "l": "(2E,6E)-farnesyl diphosphate = (+)-exo-beta-bergamotene + diphosphate", "d": []}, {"i": "EC:4.2.3.211", "l": "\"(+)-exo-beta-bergamotene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015387", "l": "potassium:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + H+(out) = K+(in) + H+(in)."]}, {"i": "RHEA:28490", "l": "H(+)(in) + K(+)(in) = H(+)(out) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59407", "l": "L-homoserine <=> D-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53252", "l": "lathosterol + O2 + reduced [NADPH--hemoprotein reductase] = 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53701", "l": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67425", "l": "a glycerophospholipid + H2O => a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11027", "l": "ATP + NH4(+) <=> ADP + 2 H(+) + phosphoramidate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71575", "l": "5-phosphomethyl-dUMP in DNA + putrescine = 5-N(alpha)-putrescinyl-dTMP in DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.2", "l": "\"dynein ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034871", "l": "1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity", "d": ["Catalysis of the reaction: 1-hydroxy-4,4-dimethylpentan-3-one = 4,4-dimethyl-3-oxopentanal + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37651", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19354", "l": "glycocholate + H2O => cholate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874789", "l": "TFAP2C homodimer binds the EGFR gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682388", "l": "Autophagosome maturation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31111", "l": "acetyl-CoA + butanoyl-CoA = 3-oxohexanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32464", "l": "glycine + 2 S-adenosyl-L-methionine => 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047551", "l": "2-oxoaldehyde dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo acid + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61767", "l": "stevioside + UDP-alpha-D-glucose <=> H(+) + rebaudioside E + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209168", "l": "Phosphorylation of SMO by CKIalpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48031", "l": "H2O + triacetin <=> acetate + diacetylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211968", "l": "CYP2W1 oxidises INDOL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864577", "l": "TFAP2C translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27809", "l": "acetoacetate + acetyl-CoA <=> acetate + acetoacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11928", "l": "hydroxylamine + NH4(+) = H(+) + H2O + hydrazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663232", "l": "FMNL1 binds RAC1:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35230", "l": "H(+)(out) + rifampicin(in) <=> H(+)(in) + rifampicin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16510", "l": "H(+) + oxalate => CO2 + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16245", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}, {"i": "EC:2.3.1.121", "l": "\"1-alkenylglycerophosphoethanolamine O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199425", "l": "PHLPP dephosphorylates S473 in AKT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72270", "l": "chloride(out) + formate(in) <=> chloride(in) + formate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951727", "l": "cAMP binds PKA tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112385", "l": "Addition of nucleotides leads to transcript elongation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1671687", "l": "PRLR activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63818", "l": "AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) => ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.12.-", "l": "\"Exodeoxyribonucleases producing 3'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46790", "l": "a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685219", "l": "SARS-CoV-1 nsp3 deubiquinates K63-linked pUb oligo-TRAF6 (TLR7/8 signaling) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102394", "l": "4-hydroxy-L-isoleucine dehydrogenase activity", "d": ["Catalysis of the reaction: (2S,3R,4S)-4-hydroxy-L-isoleucine + NAD = (2S,3R)-2-amino-3-methyl-4-ketopentanoate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59754", "l": "CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein] => L-lysyl-[protein] + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008924", "l": "malate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: (S)-malate + a quinone = oxaloacetate + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66777", "l": "ATP + H2O + uroporphyrin III(in) => ADP + H(+) + phosphate + uroporphyrin III(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24051", "l": "phosphate + sucrose <=> alpha-D-glucose 1-phosphate + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9646685", "l": "Aggresome dissociates from dynein and microtubule (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66604", "l": "a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O = a 2'-deoxyuridine in double-stranded DNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061503", "l": "tRNA threonylcarbamoyladenosine dehydratase", "d": ["Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111879", "l": "PIP2 hydrolysis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52343", "l": "a long-chain fatty acyl-AMP + holo-[mycocerosate synthase] <=> AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004591", "l": "oxoglutarate dehydrogenase (succinyl-transferring) activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417820", "l": "P2Y9 receptor can bind to LPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23738", "l": "5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) => 5-hydroxyisourate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19766", "l": "glycerol => 3-hydroxypropanal + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72746", "l": "leukotriene C4(out) <=> leukotriene C4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22597", "l": "cephalosporin C + H2O => acetate + deacetylcephalosporin C + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0018237", "l": "urease activator activity", "d": ["Increases the activity of urease by promoting the incorporation of nickel into the active site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44470", "l": "1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-190141", "l": "ALAD binds to Pb2+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114683", "l": "Phosphorylation of Platelet Sec-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727349", "l": "XDH dehydrogenates xanthine to form urate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21326", "l": "H2O2 + oxidized [rubredoxin] => 2 H(+) + reduced [rubredoxin] + superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11791", "l": "H2O + L-aspartate + NAD(+) <=> H(+) + NADH + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193641", "l": "IKK-beta is recruited (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4085992", "l": "SUMOylation of DAXX with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15856", "l": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) <=> 17alpha-hydroxyprogesterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11330", "l": "diphosphate + neryl diphosphate => dimethylallyl diphosphate + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730843", "l": "Phosphorylation of LAT by p-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74517", "l": "aspoquinolone B => (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40215", "l": "FADH2 + O2 = FAD + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42937", "l": "S-adenosyl-L-methionine + uridine(32) in tRNA => 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73134", "l": "8-hydroxy-7-methoxyflavone + S-adenosyl-L-methionine <=> 7,8-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008114", "l": "phosphogluconate 2-dehydrogenase activity", "d": ["Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445079", "l": "Phosphorylation of L1 by ERK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43589", "l": "globoside NORint + UDP-alpha-D-galactose => globoside NOR2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42095", "l": "all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139905", "l": "Translocation of activated BAD protein to mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.65", "l": "\"peptidase 1 (mite)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63084", "l": "chloride + FADH2 + ilicicolin B + O2 = FAD + H(+) + 2 H2O + ilicicolin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-377644", "l": "Release of CSK from SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202722", "l": "CD48 binds CD244 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31035", "l": "arabidiol = (S)-2,3-epoxysqualene + H2O", "d": []}, {"i": "EC:4.2.1.124", "l": "\"arabidiol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-741411", "l": "CYLD deubiquitinates NEMO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37315", "l": "glycyl-L-glutamine + H2O = glycine + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70882", "l": "L-glutamine(in) + L-threonine(out) + Na(+)(out) <=> L-glutamine(out) + L-threonine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51882", "l": "(2Z,4E)-2,3,5-trichloromuconate + H(+) => 3,4,6-trichlorocatechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449115", "l": "IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22907", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46707", "l": "ATP + H(+) + salicylate <=> 2-hydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49561", "l": "D-sedoheptulose 7-phosphate => (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689861", "l": "Recruitment of XPA and release of CAK  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56772", "l": "2 AH2 + all-trans-adonixanthin + 2 O2 = 2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70380", "l": "3-oxosphinganine + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647632", "l": "CASP3 cleaves GSDME (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62198", "l": "acetone + 2 Fe(II)-[cytochrome c] + 2 H(+) => 2 Fe(III)-[cytochrome c] + propan-2-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69561", "l": "D-mannose(out) + H(+)(out) => D-mannose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31189", "l": "3-oxodecanoyl-CoA + H(+) + NADH => (3S)-hydroxydecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0050265", "l": "RNA uridylyltransferase activity", "d": ["Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42398", "l": "2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine => cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69773", "l": "a short-chain fatty acid + 2 H(+) + NADH => a short-chain fatty aldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848596", "l": "PTK6 binds PXN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71049", "l": "glycine(out) + L-phenylalanine(in) => glycine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26211", "l": "acetaldehyde + glycine => L-allo-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0043364", "l": "glycyl-radical enzyme activating activity", "d": ["Catalyzes the activation of an enzyme by generating an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709454", "l": "EPOR binds EPOR agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31090", "l": "acetyl-CoA + octanoyl-CoA <=> 3-oxodecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949276", "l": "RUNX3:CBFB binds the RORC gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730528", "l": "SARS-CoV-2 3a binds to STING (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11020", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.127", "l": "\"inositol-trisphosphate 3-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74504", "l": "H(+) + NADPH + yaequinolone D => H2O + NADP(+) + penigequinolone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734687", "l": "ORC6 is phosphorylated on T195 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49173", "l": "8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17252", "l": "2 Fe(2+) + 2 H2O + H2O2 <=> 6 H(+) + 2 iron(III) oxide-hydroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607736", "l": "MALT1 oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48248", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) = CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52789", "l": "chlorophyll a + 2 H(+) => Mg(2+) + pheophytin a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675198", "l": "Activated MAPKs phosphorylate BRAF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790041", "l": "Expression of STAT3-upregulated cytosolic proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68852", "l": "(2E,6E)-farnesyl diphosphate + H2O = (1S,6S,7R)-sesquipiperitol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043333", "l": "2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity", "d": ["Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71277", "l": "2 Na(+)(in) + taurolithocholate 3-sulfate(in) => 2 Na(+)(out) + taurolithocholate 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23789", "l": "acetate + ATP + holo-[citrate lyase ACP] => acetyl-[citrate lyase ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15916", "l": "ATP + thiamine phosphate <=> ADP + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51707", "l": "S-adenosyl-L-methionine + xanthohumol <=> 4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61498", "l": "an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+) => an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16613", "l": "acetyl-CoA + an arylamine = an N-acetylarylamine + CoA", "d": []}, {"i": "EC:2.3.1.5", "l": "\"arylamine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54428", "l": "4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O = ADP-D-ribose + H(+) + L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51625", "l": "formate + GTP + H(+) => CO2 + dGTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33763", "l": "a (2E)-enoyl-CoA + H(+) + NADPH = a 2,3-saturated acyl-CoA + NADP(+)", "d": []}, {"i": "EC:1.3.1.38", "l": "\"trans-2-enoyl-CoA reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34075", "l": "an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate", "d": []}, {"i": "EC:2.3.1.275", "l": "\"acyl phosphate:glycerol-3-phosphate acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21295", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16487", "l": "1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53265", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050338", "l": "thiosulfate dehydrogenase activity", "d": ["Catalysis of the reaction: 2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450551", "l": "AUF1 binds translation and heat shock proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.4.4", "l": "\"vitamin-K-epoxide reductase (warfarin-sensitive)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950342", "l": "EBI3:CANX binds IL27 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60184", "l": "ATP + D-glucose(out) + H2O = ADP + D-glucose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0031795", "l": "G protein-coupled GABA receptor binding", "d": ["Binding to a G protein-coupled (metabotropic) GABA receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341072", "l": "SUMOylation of RARA with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41140", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483219", "l": "PC is exchanged with PI by PITPNB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42841", "l": "acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH => 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69932", "l": "inosine(out) + Na(+)(out) => inosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33963", "l": "ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate", "d": []}, {"i": "EC:2.7.4.26", "l": "\"isopentenyl phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71725", "l": "H(+)(in) + L-alanyl-L-leucyl-L-alanine(in) => H(+)(out) + L-alanyl-L-leucyl-L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19826", "l": "(2E,6E)-farnesyl diphosphate => (+)-aristolochene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60614", "l": "1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-octanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426149", "l": "SREBP1A,1C,2 binds the ELOVL6 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2467775", "l": "Autocleavage of ESPL1 (Separase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11287", "l": "hydroxymalonate + NAD(+) <=> H(+) + NADH + oxomalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12380", "l": "L-2,4-diaminobutanoate + pyruvate = L-alanine + L-aspartate 4-semialdehyde", "d": []}, {"i": "EC:2.6.1.46", "l": "\"diaminobutyrate--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56856", "l": "A + an aldehyde + H2O = a carboxylate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43224", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30888", "l": "4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin => 7,8-dihydropteroate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32698", "l": "(2E)-geranyl diphosphate <=> (-)-car-3-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30022", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + H(+) + lipid A-core", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74999", "l": "deoxyerythrostominol(in) = deoxyerythrostominol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39807", "l": "octadecanoate(in) = octadecanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26176", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine = 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.1.13", "l": "\"L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684006", "l": "KPNA2 translocates NBN to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647660", "l": "GSDME (1-270) binds PIPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428918", "l": "Dissociation of the TP:G13 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849878", "l": "PSD-95 binds NMDA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904492", "l": "Ac-Asp-Glu binding", "d": ["Binding to Ac-Asp-Glu."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712208", "l": "odorant:Olfactory Receptor:GNAL:GTP:GNB1:GNG13 dissociates yielding GNAL:GTP (G alpha-olf:GTP), odorant:OlfactoryReceptor, and GNB1:GNG13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22235", "l": "H(+) + NADPH + presqualene diphosphate <=> diphosphate + NADP(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28304", "l": "diphosphate + germacrene C => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13664", "l": "H2O + N-formimidoyl-L-aspartate <=> N-formyl-L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5362522", "l": "ALDHs oxidise atRAL to atRA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14104", "l": "[eIF5A protein]-deoxyhypusine + AH2 + O2 <=> [eIF5A protein]-hypusine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36318", "l": "2 H(+) + hexadecanoyl-CoA + 2 NADPH <=> CoA + hexadecan-1-ol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047878", "l": "erythritol kinase activity", "d": ["Catalysis of the reaction: ATP + erythritol = D-erythritol 4-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429714", "l": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75798", "l": "Na(+)(out) + nicotinate(out) <=> Na(+)(in) + nicotinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174916", "l": "Formation of N-glucuronides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68405", "l": "(2R,3S)-iso(homo)2citrate + NAD(+) => 2-oxoheptanedioate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444572", "l": "Zinc is an agonist of GPR39 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18867", "l": "(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0051018", "l": "protein kinase A binding", "d": ["Binding to a protein kinase A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793666", "l": "MDM2 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70022", "l": "O2 + reduced [NADPH--hemoprotein reductase] + typhasterol <=> 7-oxatyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17358", "l": "O2 + 2 R'C(R)SH => H2O2 + R'C(R)S-S(R)CR'", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17677", "l": "2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)", "d": []}, {"i": "EC:3.5.1.66", "l": "\"2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23727", "l": "H2O + O2 + pyridoxal <=> 4-pyridoxate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70486", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in single-stranded DNA + H2O + O2 <=> a 2'-deoxyguanosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167419", "l": "The receptor:G-protein complex releases GDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65746", "l": "CO2 + decanal + H(+) + succinate + sulfate => 2-oxoglutarate + decyl sulfate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714580", "l": "SLC6A3 binds DRIs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53480", "l": "3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH = 5alpha-androstane-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16829", "l": "an aldehyde + H2O + O2 = a carboxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762246", "l": "ANGPTL4 binds CDH11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809140", "l": "IL35 binds IL-12RB2:IL6ST receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64656", "l": "(E)-sinapaldehyde + CoA + NADP(+) = (E)-sinapoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9761474", "l": "AMOT-2 binds CDH11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197690", "l": "Detachment of WASP/WAVE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37067", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.8.4.3", "l": "\"tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340560", "l": "PORCN-inhibitor LGK974 prevents WNT ligand palmitoyltation and secretion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66818", "l": "2 Na(+)(out) + tetrahydroxoborate(out) => 2 Na(+)(in) + tetrahydroxoborate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38890", "l": "H2O + N-hexanoyl-sphinganine <=> hexanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714481", "l": "RAC2 binds effectors at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46108", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2 = (2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679000", "l": "Ivacaftor binds CFTR G551D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74593", "l": "5-dehydro-6-demethoxyfumagillol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (+)-exo-beta-bergamotene + 3 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047437", "l": "4-oxalocrotonate decarboxylase activity", "d": ["Catalysis of the reaction: 4-oxalocrotonate = CO2 + 2-oxopent-4-enoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43340", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032563", "l": "dADP binding", "d": ["Binding to dADP, deoxyadenosine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38178", "l": "all-trans-retinol + hexadecanoyl-CoA <=> all-trans-retinyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605052", "l": "NR1H3 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.89", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160931", "l": "Disassembly of tight junctions (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264615", "l": "Loading of acetylcholine in synaptic vesicles (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75157", "l": "diphosphate + verrucosan-2beta-ol => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63100", "l": "H(+) + ilicicolin C + NADPH + O2 = ascochlorin + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29385", "l": "2'-deoxyinosine + phosphate => dIMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451033", "l": "(S)-Malate <=> Fumarate + H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626681", "l": "Recruitment of transition zone proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374251", "l": "DARC  is a non-specific receptor for many chemokines (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632182", "l": "PRMT1 methylates ESRs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35724", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53397", "l": "a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14070", "l": "D-fructose + NADP(+) => 5-dehydro-D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047078", "l": "3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity", "d": ["Catalysis of the reaction: O2 + 3-hydroxy-1H-quinolin-4-one = carbon monoxide + N-formylanthranilate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38918", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042409", "l": "caffeoyl-CoA O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170159", "l": "Translocation of Cdc25 to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23474", "l": "alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose => 2 alpha,alpha'-trehalose 6-mycolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22553", "l": "3'-phosphoadenylyl sulfate + an alcohol => adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69362", "l": "3-bromo-L-tyrosyl-[protein] + 2 H2O => bromide + H(+) + H2O2 + L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189062", "l": "lactose + H2O => D-glucose + D-galactose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69127", "l": "Formation of the Flap Intermediate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3662344", "l": "Defective HEXB does not cleave the terminal GalNAc from DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191303", "l": "FDPS dimer transfers IPPP to GPP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50200", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640862", "l": "Tankyrase binds AXIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14009", "l": "2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.67", "l": "\"chrysanthemyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66724", "l": "(S)-lactate + L-phenylalanine = H2O + N-[(S)-lactoyl]-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709883", "l": "BIL:ALB scavenges O2.- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41310", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64396", "l": "glycyl-sarcosine(out) + H(+)(out) = glycyl-sarcosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54816", "l": "L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)", "d": []}, {"i": "EC:2.3.2.13", "l": "\"protein-glutamine gamma-glutamyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34294", "l": "2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose <=> 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951951", "l": "RUNX3 binds EP300 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928583", "l": "FYN phosphorylates NMDAR2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141437", "l": "Formation of the MCC complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39866", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45778", "l": "(indol-3-yl)acetate + NH4(+) => (indol-3-yl)acetonitrile + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047730", "l": "carnosine synthase activity", "d": ["Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174551", "l": "Formation of alternative pathway C5 convertase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199456", "l": "PTEN dephosphorylates PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864569", "l": "WWOX binds TFAP2C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619367", "l": "CaMKKs phosphorylate CAMK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429992", "l": "PARN deadenylates mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67978", "l": "beta-zeacarotene => all-trans-neurosporene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32484", "l": "H(+) + H2O + pheophorbide a => CO2 + methanol + pyropheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0015556", "l": "C4-dicarboxylate transmembrane transporter activity", "d": ["Enables the transfer of C4-dicarboxylate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30590", "l": "2-demethylmenaquinol-8 + dimethyl sulfoxide <=> 2-demethylmenaquinone-8 + dimethyl sulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54934", "l": "(2E,9Z)-hexadecadienoyl-[ACP] + H2O => (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013158", "l": "CDC42 GDIs block activation of CDC42 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696947", "l": "USP47 deubiquitinates POLB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55564", "l": "4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756666", "l": "EOMES and TBXT (T, Brachyury) bind the SNAI1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191825", "l": "Nuclear export of snRNA transcripts (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917730", "l": "Cargo Recognition And Sorting (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901611", "l": "phosphatidylglycerol binding", "d": ["Binding to phosphatidylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48729", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201316", "l": "Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102136", "l": "3-epi-6-deoxocathasterone C-23 hydroxylase activity", "d": ["Catalysis of the reaction: H+ + 3-epi-6-deoxocathasterone + reduced (NADPH-hemoprotein reducdtase) + O2 = 6=deoxotyphasterol + oxidized (NADPH-hemoprotein reductase) + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047088", "l": "dihydrosanguinarine 10-monooxygenase activity", "d": ["Catalysis of the reaction: dihydrosanguinarine + H+ + NADPH + O2 = 10-hydroxydihydrosanguinarine + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0089721", "l": "phosphoenolpyruvate transmembrane transporter activity", "d": ["Enables the transfer of a phosphoenolpyruvate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354173", "l": "Activation of Rap1 by cytosolic GEFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61562", "l": "gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19818", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45388", "l": "H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975878", "l": "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204798", "l": "Interaction of Tie2 and p85 of PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29947", "l": "H(+)(in) + L-rhamnopyranose(in) = H(+)(out) + L-rhamnopyranose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690493", "l": "RHOB binds effectors on endosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661419", "l": "ALB binds extracellular heme (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173725", "l": "C9 binds C5b:C6:C7:C8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42253", "l": "H(+) + malonyl-[ACP] + pentanoyl-CoA => 3-oxoheptanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66732", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63671", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202960", "l": "Caspase mediated cleavage of C-IAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210285", "l": "Trans-homophilic interaction of PECAM-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170149", "l": "Translocation of active Cdc25C to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0016716", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61377", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73864", "l": "dopamine(out) => dopamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44415", "l": "3-demethylubiquinol-10 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140903", "l": "histone H3R26 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 26) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 26). This reaction is the addition of a methyl group to the arginine residue at position 26 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443831", "l": "14-3-3-zeta binds Raf1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41756", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 = 1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427409", "l": "Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12104", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP", "d": []}, {"i": "EC:2.1.1.45", "l": "\"thymidylate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705926", "l": "AR binds AR agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73361", "l": "AMP + beta-alanyl-dopamine + diphosphate + H(+) => ATP + beta-alanine + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52026", "l": "18S-resolvin E2 + A + H2O => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46811", "l": "[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine <=> [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69904", "l": "cytidine(out) + 2 Na(+)(out) => cytidine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51513", "l": "H2O + oxamate => NH4(+) + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21596", "l": "L-serine + NADP(+) = 2-aminomalonate semialdehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14976", "l": "L-aspartate <=> D-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24022", "l": "fumarate + L-arginine => 2-(N(omega)-L-arginino)succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58955", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rh1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004495", "l": "mevaldate reductase activity", "d": ["Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70192", "l": "ATP + NAD(+) => 3'-NADP(+) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2731141", "l": "Syndecan-1 binds fibronectin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20964", "l": "2-oxoglutarate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.2.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847635", "l": "Formation of cis-SNARE complex and membrane fusion in intra-Golgi retrograde traffic (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8866277", "l": "AP-2 directly binds some endocytic cargo (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036037", "l": "Defective IDUA does not hydrolyse Heparan sulfate chain(1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807106", "l": "PTEN undergoes monoubiquitination (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71785", "l": "3-methyl-2-oxobutanoate(in) + H(+)(in) => 3-methyl-2-oxobutanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73123", "l": "isorhamnetin + S-adenosyl-L-methionine = H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849428", "l": "PTPN1 binds PTK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63875", "l": "2-oxoglutarate + L-isoleucine + O2 <=> 3(1)-hydroxy-L-isoleucine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14411", "l": "H(+) + hypotaurine => cysteamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734713", "l": "ORC6 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215295", "l": "USP7 deubiquitinates MDM2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937792", "l": "RUNX3 binds SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64779", "l": "3-sulfanylpentan-1-ol-L-cysteine <=> 2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008430", "l": "selenium binding", "d": ["Binding to a selenium (Se) ion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033745", "l": "L-methionine-(R)-S-oxide reductase activity", "d": ["Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38766", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63302", "l": "H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine => N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004522", "l": "ribonuclease A activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-481010", "l": "Surface deployment of platelet dense granule membrane components (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.226", "l": "\"N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22645", "l": "O2 + protopine + reduced [NADPH--hemoprotein reductase] => 6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3777129", "l": "HDAC3 containing complexes deacetylate histone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2465940", "l": "atRAL is reduced to atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509838", "l": "ITPA hydrolyses dITP to dIMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678925", "l": "NR3C1 binds NR3C1 agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12515", "l": "D-aspartate + H2O + O2 <=> H2O2 + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43106", "l": "A + an N-acyleicosasphing-4-enine + 2 H2O => AH2 + an N-acyleicosasphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61413", "l": "ATP + N-(D-erythrulosyl)-cadaverine => ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30185", "l": "H(+) + keto-D-tagaturonate + NADH => L-galactonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21432", "l": "(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29846", "l": "ATP + CoA + propanoate <=> ADP + phosphate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72013", "l": "glutathione(out) + urate(in) => glutathione(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49429", "l": "CTP + phosphonoformate => CMP-5'-phosphonoformate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42127", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) <=> androsterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65089", "l": "asperaculane E + O2 + reduced [NADPH--hemoprotein reductase] => asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25481", "l": "acetoacetate + succinyl-CoA => acetoacetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205321", "l": "Interaction of KIT and sSCF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675790", "l": "MTORC1 dissociates from ULK complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31380", "l": "H2O + pyrrole-2-carboxylate => 1H-pyrrole + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21505", "l": "acetoin + aldehydo-D-ribose 5-phosphate => 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75244", "l": "FASL binds FAS Receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15480", "l": "3'-phosphoadenylyl sulfate + 5beta-scymnol <=> 5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32940", "l": "a 1,2-diacyl-sn-glycerol + CDP-choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46807", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine <=> a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2731141", "l": "Syndecan-1 binds fibronectin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050557", "l": "deacetylipecoside synthase activity", "d": ["Catalysis of the reaction: deacetylipecoside + H2O = dopamine + secologanin."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004642", "l": "phosphoribosylformylglycinamidine synthase activity", "d": ["Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5622129", "l": "FABP5 binds atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13640", "l": "H(+) + methane + NADH + O2 <=> H2O + methanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877187", "l": "P2X7 mediates loss of intracellular K+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202966", "l": "Caspase mediated cleavage of HIP-55 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0097507", "l": "hypoxanthine DNA N-glycosylase activity", "d": ["DNA N-glycosylase activity acting on deaminated adenine (hypoxanthine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52241", "l": "2 H2O + 2 Mn(2+) + O2 => 4 H(+) + 2 MnO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047451", "l": "(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O +  (2E)-octenoyl-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71234", "l": "2 Fe(3+)-[Dph3] + NADH <=> 2 Fe(2+)-[Dph3] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44237", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2471621", "l": "Endostatin degradation by cathepsins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27501", "l": "3',5'-di-O-methyltricetin + S-adenosyl-L-methionine = 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169398", "l": "ISGylation of host protein filamin B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703440", "l": "FLT3 fusions:GRB2 bind GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0016906", "l": "sterol 3-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72103", "l": "Formation of pre-mRNPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691621", "l": "C5 binds C5 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76074", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) <=> (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016207", "l": "4-coumarate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36919", "l": "(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75570", "l": "acetyl-CoA + cyathatriol <=> 11-O-acetylcyathatriol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59136", "l": "ATP + citrate + D-ornithine = AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine", "d": []}, {"i": "EC:6.3.2.58", "l": "\"D-ornithine--citrate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46340", "l": "ATP + N-hexadecanoylsphing-4-enine = ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19971", "l": "H(+) + H2O + nitrite => hydroxylamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787566", "l": "PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36664", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA => (2S,5S)-5-carboxymethylproline + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080032", "l": "methyl jasmonate esterase activity", "d": ["Catalysis of the reaction: a methyl jasmonate + H2O = a jasmonic acid + methanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32238", "l": "(6S)-NADPHX + ADP <=> AMP + H(+) + NADPH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18818", "l": "acetyl-CoA + malonate => acetate + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45952", "l": "L-asparaginyl-[protein] + UDP-alpha-D-glucose = H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19136", "l": "2-oxoglutarate + 3,3',5-triiodo-L-thyronine <=> 3,5,3'-triiodothyropyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045486", "l": "naringenin 3-dioxygenase activity", "d": ["Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875816", "l": "STAT3 binds activated MET receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70999", "l": "(S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66091", "l": "L-kynurenine + oxaloacetate <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227778", "l": "MEKK1 binds TRAF6  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28124", "l": "ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+) => ATP + di-trans,octa-cis-undecaprenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879221", "l": "PSTPIP1 binds Pyrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50286", "l": "(12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35461", "l": "cholest-5-en-3-one + H(+) + NADH => cholesterol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36550", "l": "octadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-(octadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390663", "l": "ADRA2A,B,C bind ADR,NAd (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28716", "l": "(R)-malate(in) + 2 H(+)(in) => (R)-malate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53242", "l": "cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853792", "l": "RET tyrosine phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14910", "l": "L-gulonate + NADP(+) => aldehydo-D-glucuronate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64312", "l": "2 chloride + 2 FADH2 + 2 O2 + sulochrin = dihydrogeodin + 2 FAD + H(+) + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112690", "l": "PTPN11 binds CBL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30882", "l": "H2O + NAD(+) + prop-2-ynal <=> 2 H(+) + NADH + propynoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53128", "l": "delta-carotene = epsilon-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43335", "l": "adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102103", "l": "demethoxycurcumin synthase", "d": ["Catalysis of the reaction: (4-coumaroyl)acetyl-CoA + 4-coumaryl-CoA + H2O <=> bisdemethoxycurcumin + 2 coenzyme A + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51837", "l": "(9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65709", "l": "alpha-D-mannose 1-phosphate + GDP-beta-L-galactose => beta-L-galactose 1-phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165162", "l": "Phosphorylation of TSC2 by PKB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58703", "l": "FADH2-C4alpha-hydroperoxide + NADPH + rifampicin <=> FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9650165", "l": "ASIC trimers bind H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55049", "l": "(3E,5Z)-dodecadienoyl-CoA + H2O => (3E,5Z)-dodecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61570", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine => an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013438", "l": "RHOD binds effectors at the endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296326", "l": "HCAR1 binds LACT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191402", "l": "Reduction of presqualene diphosphate to form squalene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29045", "l": "(6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65389", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O => a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678998", "l": "Endosomal TLRs pass through the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936963", "l": "IRAK2 induces TRAF6 oligomerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68295", "l": "L-seryl-[protein] + nonanoyl-CoA <=> CoA + O-nonanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64747", "l": "H2O + S-3-(hexan-1-ol)-L-cysteine <=> 3-sulfanyl-1-hexanol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54624", "l": "2-oxoglutarate + O2 + octadecanoyl-CoA = 2-hydroxyoctadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31208", "l": "FAD + H(+) + hexanoyl-CoA => (2E)-hexenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868236", "l": "BAR domain proteins recruit dynamin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55868", "l": "(S)-lactate + O2 = H2O2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32616", "l": "(6E)-8-oxogeraniol + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73633", "l": "CTP(in) + dGTP(out) => CTP(out) + dGTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627369", "l": "SEPT4 binds XIAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54599", "l": "2-oxoglutarate + hexadecanoyl-CoA + O2 <=> 2-hydroxyhexadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0004623", "l": "phospholipase A2 activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32646", "l": "2 Fe(III)-[cytochrome c] + H2O + lupanine <=> 17-hydroxylupanine + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17826", "l": "ATP + D-glucose => ADP + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75290", "l": "glyoxylate(in) + sulfate(out) <=> glyoxylate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43777", "l": "an N-(acyl)-sphingosylphosphocholine(in) => an N-(acyl)-sphingosylphosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851011", "l": "TRIM27 polyubiquitinates PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10659", "l": "guanidinoacetate + S-adenosyl-L-methionine <=> creatine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64673", "l": "2-(methylsulfanyl)acetyl-CoA + butan-1-ol => butyl 2-(methylsulfanyl)acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42405", "l": "H2O + lactose 6-phosphate => beta-D-glucose + D-galactose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-392530", "l": "p-S400-Cot phosphorylates NIK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9681375", "l": "KIT binds ripretinib (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73962", "l": "2-methoxy-4-vinylphenol + H(+) + NADH <=> 4-ethyl-2-methoxyphenol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50932", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29743", "l": "2-phenylethylamine(in) = 2-phenylethylamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874849", "l": "CREBRF binds CREB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71391", "l": "16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) = 16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53527", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735789", "l": "Defective PNP does not convert (deoxy)guanosine to guanine and (deoxy)ribose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27548", "l": "3-hydroxyanthranilate + FAD + H(+) + H2O => anthranilate + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38774", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56240", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59753", "l": "L-lysyl-[protein] + tetradecanoyl-CoA => CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24326", "l": "1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+) => 6-oxocineole + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60410", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine => Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033727", "l": "aldehyde dehydrogenase (FAD-independent) activity", "d": ["Catalysis of the reaction: an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21440", "l": "a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 = a long-chain alkane + formate + H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28082", "l": "(2S)-ethylmalonyl-CoA + NADP(+) = (2E)-butenoyl-CoA + CO2 + NADPH", "d": []}, {"i": "EC:1.3.1.85", "l": "\"crotonyl-CoA carboxylase/reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38236", "l": "(9Z)-octadecenoyl-CoA + octadecan-1-ol => 1-O-octadecyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38314", "l": "carminomycin + S-adenosyl-L-methionine <=> daunorubicin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805546", "l": "Keratin type I binds keratin type II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106386", "l": "(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity", "d": ["Catalysis of the reaction: 3R-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416929", "l": "PTGFR binds PGF2a (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31569", "l": "2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+) => bisphenol A + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49381", "l": "5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56322", "l": "an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP => a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38190", "l": "19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043757", "l": "adenosylcobinamide-phosphate synthase activity", "d": ["Catalysis of the reactions: ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate, and ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46266", "l": "a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16305", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0046508", "l": "hydrolase activity, acting on carbon-sulfur bonds", "d": ["Catalysis of the hydrolysis of any carbon-sulfur bond, C-S."]}, {"i": "EC:3.13.-.-", "l": "\"Acting on carbon-sulfur bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30217", "l": "a menaquinone + H2O + nitrous oxide => a menaquinol + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72085", "l": "ADP-alpha-D-ribose 1''-phosphate + H(+) => ADP-alpha-D-ribose 1'',2''-cyclic phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700156", "l": "Active ALK dimer binds IRS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17624", "l": "acetyl-CoA + citramalate <=> (3S)-citramalyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814409", "l": "CK2 phosphorylates PDCL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250253", "l": "TXNIP is released from oxidized thioredoxin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34501", "l": "H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate => 1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.56", "l": "\"caspase-3\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55033", "l": "an N-methylornithine lipid + S-adenosyl-L-methionine => an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655341", "l": "Activated FGFR4 mutants phosphorylate PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35548", "l": "cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-708349", "l": "Activated NOD2 oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62728", "l": "(+)-malbrancheamide B + bromide + FAD + 2 H(+) = (+)-malbrancheamide D + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26140", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O = 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55431", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13271", "l": "an N-acylsphing-4-enine + D-glucose => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354173", "l": "Activation of Rap1 by cytosolic GEFs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798474", "l": "S100A8:S100A9 binds Zn2+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018650", "l": "styrene monooxygenase activity", "d": ["Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400063", "l": "Low conductance potassium channels in pancreatic beta cells open in response to epinephrine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050377", "l": "UDP-glucose 4,6-dehydratase activity", "d": ["Catalysis of the reaction: UDP-D-glucose = H2O + UDP-4-dehydro-6-deoxy-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757578", "l": "ALB binds PREDN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17910", "l": "(S)-lactate => acetaldehyde + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32311", "l": "L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.36", "l": "\"tyrosine N-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696822", "l": "AKR1B15 reduces EST17b to E1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202489", "l": "Oligomerization of Bcl10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74756", "l": "kaempferide + S-adenosyl-L-methionine => 3,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23858", "l": "Hg(2+) + NADPH => H(+) + Hg + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36314", "l": "3,4-dihydroxybenzaldehyde + H2O + NAD(+) <=> 3,4-dihydroxybenzoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047212", "l": "2-coumarate O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: trans-2-coumarate + UDP-D-glucose = trans-beta-D-glucosyl-2-hydroxycinnamate + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211224", "l": "Association of DFF40 with DFF45 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009072", "l": "STAT3 phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.63", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53116", "l": "an 11beta-hydroxysteroid + NAD(+) = an 11-oxosteroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45155", "l": "3-hydroxy-3-(methylsulfanyl)propanoyl-CoA <=> 3-oxopropanoyl-CoA + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36988", "l": "CMP + phosphate => alpha-D-ribose 1,5-bisphosphate + cytosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32499", "l": "(1R,5R)-sabinene + H(+) + NADPH + O2 = (1S,3R,5S)-sabinol + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.153", "l": "\"(+)-sabinene 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.42903515889401", "identifiers": [{"i": "GO:0016891", "l": "RNA endonuclease activity, producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53306", "l": "A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate => AH2 + 2 ATP + 2 cob(II)alamin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.384", "l": "\"NDP-glycosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15791", "l": "H(+) + L-xylono-1,4-lactone + NADPH => L-xylose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75736", "l": "10-oxo-(12Z)-octadecenoate => 10-oxo-(11E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450422", "l": "KSRP recruits RNA degradation activities (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63638", "l": "a medium-chain fatty acyl-[ACP] + AMP + H(+) => a medium-chain fatty acyl-AMP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5213464", "l": "RIPK1 is phosphorylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45753", "l": "(3E)-decenoyl-CoA => (2E)-decenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23106", "l": "D-ribulose 5-phosphate => D-arabinose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034556", "l": "nitrobenzoate nitroreductase activity", "d": ["Catalysis of the reaction: o-nitrobenzoate + NADPH + H+ = o-hydroxylaminobenzoate + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41768", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) = CMP + ganglioside GT1a (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102612", "l": "syn-pimaradiene 6beta-hydroxylase activity", "d": ["Catalysis of the reaction: 9beta-pimara-7,15-diene + NADPH + O2 + H+ <=> 6beta-hydroxy-syn-pimaradiene + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0030276", "l": "clathrin binding", "d": ["Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-976801", "l": "Complement factor I complex formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645428", "l": "ALPK1 binds ADP-heptose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9815510", "l": "MIB2 binds CYLD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9620103", "l": "ALDH2 transforms GTN to NO (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43298", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111883", "l": "Hydrolysis of phosphatidylcholine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34308", "l": "4-nitrocatechol + NADPH + O2 => 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.99.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45760", "l": "dTDP-beta-L-daunosamine + epsilon-rhodomycinone = dTDP + H(+) + rhodomycin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35903", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14455", "l": "(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH => 4-(phosphooxy)-L-threonine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10716", "l": "D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate", "d": []}, {"i": "EC:5.5.1.4", "l": "\"inositol-3-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52543", "l": "cytidine + phosphate <=> alpha-D-ribose 1-phosphate + cytosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30918", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O <=> a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24230", "l": "4-methylcatechol + CO2 + NADH => (1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55528", "l": "H(+) + H2O + L-tyrosine + O2 = (4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+)", "d": []}, {"i": "EC:4.1.1.108", "l": "\"4-hydroxyphenylacetaldehyde synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18663", "l": "H(+) + L-ornithine + NADPH + pyruvate => H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15416", "l": "(2R,3R)-tartrate <=> H2O + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807826", "l": "LDHAL6B reduces PYR to LACT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59230", "l": "6-sulfo-beta-D-quinovose => 6-sulfo-alpha-D-quinovose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61986", "l": "NAD(+) + ubiquinol-10 => H(+) + NADH + ubiquinone-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953398", "l": "PIR oxygenates quercetin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909720", "l": "IFN alpha/beta binds to IFNAR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17242", "l": "an alpha-amino acid ester + H2O => an alcohol + an alpha-amino acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0005506", "l": "iron ion binding", "d": ["Binding to an iron (Fe) ion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5658438", "l": "SPRED dimer binds NF1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237129", "l": "Acireductone is created (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18949", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol", "d": []}, {"i": "EC:1.14.14.106", "l": "\"taxane 13alpha-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74476", "l": "(Z)-4'-methoxydehydrocyclopeptine + 2-oxoglutarate + O2 => (-)-4'-methoxycyclopenine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432010", "l": "Aquaporin-1 passively transports water into cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990601", "l": "5' overhang single-stranded DNA endodeoxyribonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within 5' overhang single-stranded deoxyribonucleic acid by creating internal breaks."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048001", "l": "erythrose-4-phosphate dehydrogenase activity", "d": ["Catalysis of the reaction: D-erythrose 4-phosphate + H2O + NAD+ = 4-phospho-D-erythronate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210439", "l": "glutamate uptake by astrocytes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20371", "l": "glycine betaine + H(+) + H2O2 => betaine aldehyde + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55986", "l": "(R)-prunasin + H(+) + UDP => (R)-mandelonitrile + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42902", "l": "H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(745) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39778", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57524", "l": "a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004883", "l": "nuclear glucocorticoid receptor activity", "d": ["Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982792", "l": "Growth hormone receptor binds JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016680", "l": "oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces NAD or NADP."]}, {"i": "EC:1.10.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0032037", "l": "myosin I heavy chain binding", "d": ["Binding to a heavy chain of a myosin I complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65612", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52219", "l": "[(1''->2')-ADP-alpha-D-ribose](n) + H2O <=> [(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614773", "l": "MBP gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696356", "l": "OSCAR binds collagen and SP-D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381087", "l": "Dimerization of PERK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69173", "l": "Joining of adjacent Okazaki fragments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9010872", "l": "SLIT2 binds Dystroglycan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47263", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74266", "l": "n H(+)(out) + spermine(in) <=> n H(+)(in) + spermine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58557", "l": "15alpha-stemmadenine intermediate II + H2O => (16S)-deshydroxymethyl-stemmadenine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034819", "l": "3-HSA hydroxylase activity", "d": ["Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADPH + H+ + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46561", "l": "episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74576", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] => N(alpha)-acetyl-L-methionine + N-terminal L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23933", "l": "an N-acyl-D-glucosamine 6-phosphate => an N-acyl-D-mannosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373746", "l": "SEMA4D interacts with CD45 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73210", "l": "sulfate(out) + sulfite(in) <=> sulfate(in) + sulfite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48838", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51800", "l": "deoxyadlupulone + dimethylallyl diphosphate = adlupulone + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40876", "l": "(9Z,12Z)-octadecadienoyl-CoA + FAD + H(+) => (2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12355", "l": "L-gulono-1,4-lactone + O2 <=> H2O2 + L-xylo-hex-3-ulonolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378956", "l": "Luteinizing hormone is a heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27584", "l": "2-methyleneglutarate + H2O => (S)-2-hydroxymethylglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48787", "l": "D-erythrulose 4-phosphate <=> D-erythrose 4-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634943", "l": "MyrG-CDK5R1 binds CDK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43031", "l": "L-cysteate <=> 2-aminoprop-2-enoate + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17566", "l": "myo-inositol + S-adenosyl-L-methionine => 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29952", "l": "H(+)(in) + uridine(in) => H(+)(out) + uridine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047312", "l": "L-phenylalanine:pyruvate aminotransferase activity", "d": ["Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48963", "l": "[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide <=> [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36653", "l": "H(+) + novobiocic acid + S-adenosyl-L-homocysteine => 8-desmethylnovobiocic acid + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4395227", "l": "CCND1:CREBBP binds NOTCH1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20848", "l": "H(+) + O2 + phosphate + pyruvate = acetyl phosphate + CO2 + H2O2", "d": []}, {"i": "EC:1.2.3.3", "l": "\"pyruvate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30559", "l": "GTP + H2O = guanosine + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11767", "l": "H2O + methylguanidine <=> methylamine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16557", "l": "2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO2", "d": []}, {"i": "EC:4.1.1.45", "l": "\"aminocarboxymuconate-semialdehyde decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28566", "l": "3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP = 6 AMP + enterobactin + 7 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73729", "l": "Formation of SL1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875531", "l": "MET binds TNS4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55726", "l": "17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48184", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928607", "l": "p-EPHs bind VAV2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687088", "l": "PKA phosphorylates MAPKAPK5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40665", "l": "2-aminoprop-2-enoate + H2O => L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683712", "l": "3a translocates to the ERGIC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46781", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75209", "l": "Ag(+)(in) => Ag(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44852", "l": "(5Z)-tetradecenoyl-CoA + (R)-carnitine = CoA + O-(5Z)-tetradecenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15706", "l": "2 a ubiquinone + H2O + phenylacetyl-CoA => 2 a ubiquinol + phenylglyoxylyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58941", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADH => all-trans-lycopaoctaene + diphosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198314", "l": "DAG stimulates protein kinase C-delta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28751", "l": "sn-glycerol 3-phosphate + ubiquinone-8 = dihydroxyacetone phosphate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54742", "l": "19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015526", "l": "hexose-phosphate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose phosphate(out) + inorganic phosphate(in) = hexose phosphate(in) + inorganic phosphate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176445", "l": "SMURF2 binds SMAD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35341", "l": "3-oxoeicosanoyl-CoA + H(+) + NADPH => 3-hydroxyicosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265177", "l": "Exocyst complex formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193981", "l": "CYP21A2 oxidises 17HPROG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109702", "l": "PDPK1 phosphorylates AKT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36142", "l": "(E)-hexadec-2-enoate + ATP + CoA <=> (2E)-hexadecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14322", "l": "morphine + NADP(+) => H(+) + morphinone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41923", "l": "3-oxooctadecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28071", "l": "(2E,6E)-farnesyl diphosphate + H2O + heme b => diphosphate + Fe(II)-heme o", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052753", "l": "propan-2-ol:coenzyme F420 oxidoreductase activity", "d": ["Catalysis of the reaction: propan-2-ol + coenzyme F420 = acetone + reduced coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199456", "l": "PTEN dephosphorylates PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698925", "l": "Packaging of Viral Genome Into C Capsids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237129", "l": "Acireductone is created (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17280", "l": "6-phospho-D-gluconate <=> 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805638", "l": "KAT6A acetylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202947", "l": "Caspase mediated cleavage of APC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56370", "l": "3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+) => 3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5220959", "l": "TDG excises 5-formylcytosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65253", "l": "(2E,6E)-farnesyl diphosphate + 6-hydroxymellein => diphosphate + verruculide C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46359", "l": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52592", "l": "deoxycholoyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17850", "l": "(3R)-3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16853", "l": "N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36911", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373747", "l": "Phosphorylation of nephrin by FYN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33618", "l": "ATP + CoA + octadecanoate <=> AMP + diphosphate + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0061980", "l": "regulatory RNA binding", "d": ["Binding to a small regulatory RNA, a short RNA (usually 50-200 nt long) that is either independently transcribed or processed from a longer RNA by an RNAse enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70549", "l": "3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0048028", "l": "galacturonan binding", "d": ["Binding to a simple or complex galacturonan. Galacturonan is any glycan composed solely of galacturonic acid residues, a specific type of glycuronan, and a constituent of some pectins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41479", "l": "an acyl-CoA + zymosterol <=> CoA + zymosterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009899", "l": "ent-kaurene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-kaur-16-ene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48643", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) <=> 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50105", "l": "taurine + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015344", "l": "siderophore uptake transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102464", "l": "zeaxanthin 2-beta-hydroxylase activity", "d": ["Catalysis of the reaction: zeaxanthin + O2 + NADH + H+ <=> caloxanthin + H2O + NAD."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47281", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1454916", "l": "The ABCC family mediates organic anion transport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49580", "l": "(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate", "d": []}, {"i": "EC:4.6.1.17", "l": "\"cyclic pyranopterin monophosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203774", "l": "Interaction of Csk with PAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33650", "l": "(9Z)-hexadecenoate + ATP + CoA <=> (9Z)-hexadecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59961", "l": "N(alpha)-acetyl-D-methionine => N(alpha)-acetyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937079", "l": "MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995334", "l": "COX15 transforms heme O to heme A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32868", "l": "myo-inositol(out) => myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19379", "l": "2 H(+) + NADPH + riboflavin => NADP(+) + reduced riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204779", "l": "Interaction of Tie2 with Ang1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807872", "l": "Active ARF recruits coatomer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14831", "l": "acetate + L-cysteine => hydrogen sulfide + O-acetyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42558", "l": "pseudouridine(2819) in 21S rRNA => uridine(2819) in 21S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209072", "l": "PLL kinase binds to TL:MYD88:TUB 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63088", "l": "a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17582", "l": "an N-carbamoyl-L-alpha-amino acid + 2 H(+) + H2O => an L-alpha-amino acid + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16366", "l": "digallate + H2O => 2 3,4,5-trihydroxybenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.5", "l": "\"phosphoglucomutase (glucose-cofactor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39712", "l": "O2 + 2 reduced coenzyme F420-(gamma-L-Glu)(n) => 2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2197690", "l": "Detachment of WASP/WAVE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54175", "l": "H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-acyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67189", "l": "ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out) => ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421831", "l": "trans-Golgi Network Coat Assembly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669874", "l": "Sorafenib-resistant KIT mutants do not bind sorafenib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10826", "l": "H(+) + NADPH + oxaloacetate => (S)-malate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956659", "l": "ABL1 phosphorylates YAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13111", "l": "H(+) + N-hydroxy-2-acetamidofluorene + NADH => 2-acetamidofluorene + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668605", "l": "RAC2:GTP binds NOX2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167415", "l": "G-protein alpha subunit is inactivated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21703", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O <=> 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008503", "l": "benzodiazepine receptor activity", "d": ["Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20182", "l": "alpha-D-mannose derivative + UDP-alpha-D-glucose => 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097690", "l": "iron ion transmembrane transporter inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of an iron ion transmembrane transporter."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132222", "l": "Cleavage of factor B to form classical C3 convertase  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12896", "l": "prostaglandin H2 <=> prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10387", "l": "cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate <=> beta-cyclopiazonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31899", "l": "indole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.153", "l": "\"indole-2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852019", "l": "MET bound PI3K generates PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16635", "l": "guanine + queuosine(34) in tRNA => guanosine(34) in tRNA + queuine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30558", "l": "GTP + L-glutamate + oxidized coenzyme F420-0 <=> GDP + H(+) + oxidized coenzyme F420-1 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11318", "l": "a nitrile + H2O => an aliphatic aldoxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14560", "l": "H2O + raucaffricine <=> D-glucose + vomilenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27346", "l": "FMNH2 + O2 => 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696146", "l": "AOC2 deaminates TYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296043", "l": "Activation of HCN channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42489", "l": "(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III => 3'-N-debenzoyl-2'-deoxytaxol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61739", "l": "steviolmonoside + UDP-alpha-D-glucose <=> rubusoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818682", "l": "MEN1 binds MLL2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35967", "l": "fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.119", "l": "\"fumitremorgin C monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006122", "l": "BDNF gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102327", "l": "3-oxoacyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: H2O + a 3-oxoacyl-CoA = H+ + coenzyme A + a 3-oxoacid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353273", "l": "Elongation by Pol zeta complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67068", "l": "AH2 + chermesin D methyl ester = A + asnovolin J", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990829", "l": "C-rich single-stranded DNA binding", "d": ["Binding to C-rich, single-stranded DNA."]}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0005388", "l": "P-type calcium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514790", "l": "Elastin degradation by MMP14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985591", "l": "SLIT2-bound ROBO1 binds MYO9B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607744", "l": "MALT1 binds BCL10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052792", "l": "endo-xylogalacturonan hydrolase activity", "d": ["Catalysis of the endohydrolysis of xylogalacturonate by cleavage of the alpha-(1,4)-linkage. Xylogalacturonate (XGA) is composed of a chain of alpha-(1,4)-linked D-galacturonic acid residues with beta-D-xylose substituted at the O3 position."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53654", "l": "(5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27465", "l": "ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate", "d": []}, {"i": "EC:2.7.7.70", "l": "\"D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14073", "l": "3-hydroxy-L-glutamate + H(+) = 4-amino-3-hydroxybutanoate + CO2", "d": []}, {"i": "EC:4.1.1.16", "l": "\"hydroxyglutamate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17146", "l": "2'-hydroxy-2,3-dihydrodaidzein + NADP(+) => 2'-hydroxydaidzein + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59688", "l": "D-maltoheptaose + O2 = D-maltoheptaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380272", "l": "Plk1-mediated phosphorylation of Nlp (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42915", "l": "cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74971", "l": "L-leucine(out) + L-lysine(in) + Na(+)(out) = L-leucine(in) + L-lysine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.51", "l": "\"cruzipain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419269", "l": "TSFM binds TUFM displacing GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70921", "l": "chloride(in) + dopamine(in) + Na(+)(in) => chloride(out) + dopamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17917", "l": "[Glu(-Cys)](n)-Gly + glutathione + H(+) = [Glu(-Cys)](n+1)-Gly + glycine", "d": []}, {"i": "EC:2.3.2.15", "l": "\"glutathione gamma-glutamylcysteinyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170120", "l": "Translocation of Cdc25B to the cytoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20091", "l": "CoA + H(+) + N-acetyl-L-leucine => acetyl-CoA + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030429", "l": "kynureninase activity", "d": ["Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18765", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1,2-diacyl-sn-glycerol + a sphingomyelin", "d": []}, {"i": "EC:2.7.8.27", "l": "\"sphingomyelin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40960", "l": "2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28020", "l": "2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine => enterobactin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374899", "l": "Release of noradrenaline  at the synapse (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.83", "l": "\"kappa-carrageenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25586", "l": "beta-L-rhamnose => alpha-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53755", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61487", "l": "a cytidine in rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45656", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789615", "l": "Expression of STAT3-upregulated extracellular proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800490", "l": "ATM phosphorylates PIDD1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018673", "l": "anthraniloyl-CoA monooxygenase activity", "d": ["Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 NADPH + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.33", "l": "\"4-hydroxybenzoate 3-monooxygenase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0046624", "l": "sphingolipid transporter activity", "d": ["Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)."]}, {"i": "REACT:R-HSA-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63213", "l": "5-amino-6-(D-ribitylamino)uracil + methylglyoxal => 5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016897", "l": "RNA exonuclease activity, producing 3'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters."]}, {"i": "EC:3.1.14.-", "l": "\"Exoribonucleases producing 3'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032841", "l": "Activated NTRK2 binds CDK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174224", "l": "Dissociation of Cdc20 from APC/C complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264848", "l": "apoA-I binds to CUBN:AMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368133", "l": "Expression of RORA (ROR-alpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "53.36916719774932", "identifiers": [{"i": "GO:0016772", "l": "transferase activity, transferring phosphorus-containing groups", "d": ["Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.7.-.-", "l": "\"Transferring phosphorus-containing groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203973", "l": "Vesicle budding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209828", "l": "Tryptophan is hydroxylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851866", "l": "MET binds RANBP10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102888", "l": "delta-cuprenene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> delta-cuprenene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34532", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose => CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636240", "l": "PPE2 binds NOS2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18625", "l": "D-galactose + NADP(+) = D-galactono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33489", "l": "CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27926", "l": "UMP(in) = UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195378", "l": "Homodimerization of VEGF proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18723", "l": "diphosphate + ent-13-epi-manoyl oxide => ent-8alpha-hydroxylabd-13-en-15-yl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59875", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002460", "l": "P4HB binds Collagen chains (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66192", "l": "ATP + bilirubin-bisglucuronoside(in) + H2O = ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210274", "l": "SIRP beta binds TYROBP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.109", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13269", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose", "d": []}, {"i": "EC:3.2.1.45", "l": "\"glucosylceramidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687107", "l": "MAPK4,6 translocate to nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24546", "l": "(S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+) => H2O + L-lysyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250220", "l": "Homodimerization of ERBB4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102990", "l": "5-n-alk(en)ylresorcinol O-methyltransferase activity", "d": ["Catalysis of the reaction: 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine <=> H+ + 5-(pentadeca-8,11,14-trien-1-yl)resorcinol monomethyl ether + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814409", "l": "CK2 phosphorylates PDCL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800490", "l": "ATM phosphorylates PIDD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54541", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] => beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37160", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27770", "l": "3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23281", "l": "acetyl-CoA + cysteamine => CoA + S-acetylcysteamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26244", "l": "geranylgeranyl diphosphate <=> diphosphate + elisabethatriene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0035514", "l": "DNA demethylase activity", "d": ["Catalysis of the removal of a methyl group from one or more nucleosides within a DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601843", "l": "Defective CYP17A1 does not 17-hydroxylate PREG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008086", "l": "light-activated voltage-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000120", "l": "CBLIF binds RCbl (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700175", "l": "Active ALK phosphorylates SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867344", "l": "OMA1 hydrolyses OPA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38222", "l": "(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167427", "l": "Opioid dissociates from MOR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429698", "l": "PRKD1,2,3 phosphorylates CERT1-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56109", "l": "genistein + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68034", "l": "(3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+) => (S)-cystathionine ketimine + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72484", "l": "(S)-malate(in) + citrate(out) => (S)-malate(out) + citrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160004", "l": "poly-ADP-D-ribose modification-dependent protein binding", "d": ["Binding to a protein upon poly-ADP-ribosylation of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44844", "l": "(R)-carnitine + eicosanoyl-CoA = CoA + O-eicosanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389523", "l": "BTLA interacts with HVEM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.13", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090612", "l": "cAMP deaminase activity", "d": ["Catalysis of the reaction: cyclic adenosine monophosphate + H2O = cyclic inosine monophosphate + NH3."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015200", "l": "methylammonium transmembrane transporter activity", "d": ["Enables directed movement of methylammonium, CH3NH2, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43065", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate => holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0140656", "l": "endodeoxyribonuclease activator activity", "d": ["Binds to and increases the activity of an endodeoxyribonuclease."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54922", "l": "13-cis-retinal + H(+) + NADPH => 13-cis-retinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34408", "l": "3 ATP => 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49954", "l": "5,10-dihydrophenazine 1-carboxylate => (10aS)-10,10a-dihydrophenazine-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981713", "l": "C4b binds to cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.3", "l": "\"homoserine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28424", "l": "2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678927", "l": "UNC93B1 delivers endosomal full-length TLRs to endolysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61615", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 <=> 7-epi-cylindrospermopsin + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655483", "l": "USP1 autocleavage (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937059", "l": "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59111", "l": "chenodeoxycholate + octyl beta-D-glucose <=> beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43893", "l": "[sulfur carrier]-H + L-cysteine => [sulfur carrier]-SH + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15045", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70971", "l": "citrate <=> isocitrate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42807", "l": "5,6,7,8-tetrahydromethanopterin + A <=> 7,8-dihydromethanopterin + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32875", "l": "a 1-acyl-sn-glycerol + H2O = a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052849", "l": "NADPH-dependent curcumin reductase activity", "d": ["Catalysis of the reaction: curcumin + NADPH + H+ = dihydrocurcumin + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42454", "l": "H2O + kynurenate => 4-(2-aminophenyl)-2,4-dioxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37569", "l": "1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803890", "l": "SFN dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617972", "l": "FOXO3 binds SOD2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430190", "l": "p-SLP-76 binds NCK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692880", "l": "HRH3 binds Hist (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67003", "l": "2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + phlorisobutanophenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23390", "l": "7''-O-phosphohygromycin B + ADP + H(+) => ATP + hygromycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793852", "l": "DLL3 binds NOTCH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008983", "l": "protein-glutamate O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17133", "l": "ATP + L-seryl-[tyrosine-3-monooxygenase] = ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]", "d": []}, {"i": "EC:2.7.11.6", "l": "\"[tyrosine 3-monooxygenase] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66667", "l": "ATP + coproporphyrin III(in) + H2O <=> ADP + coproporphyrin III(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18855", "l": "2-hydroxy-3-oxosuccinate + H(+) + NADH => NAD(+) + tartrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200646", "l": "Cytosolic folate export across the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54915", "l": "11-cis-retinol + NADP(+) <=> 11-cis-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20106", "l": "ADP + beta-D-fructose 6-phosphate => AMP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63120", "l": "(11Z)-eicosenamide + H2O = (11Z)-eicosenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31642", "l": "mycinamicin III + S-adenosyl-L-methionine <=> H(+) + mycinamicin IV + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047754", "l": "choline sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + choline = adenosine 3',5'-diphosphate + choline sulfate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790022", "l": "Expression of STAT3-upregulated plasma membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66547", "l": "L-cysteinyl-[protein] + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047313", "l": "aromatic-amino-acid-glyoxylate transaminase activity", "d": ["Catalysis of the reaction: glyoxylate + an aromatic amino acid = L-glycine + an aromatic oxo acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25919", "l": "A + H2O + quinolin-6-ol <=> 6-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11934", "l": "acetone + hydrogen cyanide => 2-hydroxy-2-methylpropanenitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093327", "l": "EPHA binds TIAM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.4", "l": "\"amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982017", "l": "Active G alpha (q) binds RGS proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668831", "l": "CST complex formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25067", "l": "(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) => (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014293", "l": "RAC2 GDIs block activation of RAC2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6790454", "l": "SUMOylation of XPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671993", "l": "CIT-3 binds DLG4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36971", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-allose", "d": []}, {"i": "EC:5.1.3.27", "l": "\"dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59113", "l": "ATP + L-serine => ADP + H(+) + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28215", "l": "[thioredoxin]-dithiol + prostaglandin H2 => [thioredoxin]-disulfide + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12065", "l": "5-oxopentanoate + H2O + NAD(+) => glutarate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928576", "l": "RHOA:GTP binds ROCK, activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14880", "l": "ATP + L-glutamate <=> ADP + L-glutamyl 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59158", "l": "AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] => ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851352", "l": "CCR8 binds CCL1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5627775", "l": "Autophosphorylation of PAK1,2,3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21350", "l": "10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2 => 8 H(+) + 10 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018756", "l": "ammeline aminohydrolase activity", "d": ["Catalysis of the reaction: ammeline + H2O = ammelide + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36593", "l": "2-chloroacrylate + H(+) + NADPH => (S)-2-chloropropanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73757", "l": "2 H(+)(in) + histamine(out) => 2 H(+)(out) + histamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60278", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51023", "l": "a primary alcohol + 2 Fe(III)-[cytochrome c] <=> an aldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59620", "l": "H2O + N(2)-(4-aminobutanoyl)-L-lysine = 4-aminobutanoate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73209", "l": "sulfate(in) + sulfite(out) => sulfate(out) + sulfite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389964", "l": "Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E+ Cofactor C-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158399", "l": "kallikrein binds SERPING1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051268", "l": "alpha-keto amide reductase activity", "d": ["Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13694", "l": "(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51471", "l": "(R)-lactate + a quinone <=> a quinol + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61121", "l": "kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22897", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH => a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177922", "l": "EGFR dimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617927", "l": "FOXO4 binds ATXN3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41489", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69310", "l": "phenylacetonitrile + sulfate + sulfur => (Z)-phenyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51373", "l": "(9Z)-hexadecenoyl-CoA + glycine => CoA + H(+) + N-(9Z-hexadecenoyl)-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75298", "l": "chloride(in) + sulfate(out) <=> chloride(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15574", "l": "N-acetylserotonin + S-adenosyl-L-methionine => H(+) + melatonin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42867", "l": "norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + norspermine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74560", "l": "aldosterone => aldosterone hemiacetal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28275", "l": "(S)-S-adenosyl-L-methionine => (R)-S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788623", "l": "p-Y-STATs translocate to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36326", "l": "(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH <=> (9Z)-octadecen-1-ol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28643", "l": "(2E,6E)-farnesyl diphosphate = alpha-zingiberene + diphosphate", "d": []}, {"i": "EC:4.2.3.65", "l": "\"zingiberene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497855", "l": "Ascorbate can reduce the BH3 radical back to BH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002039", "l": "p53 binding", "d": ["Binding to one of the p53 family of proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21139", "l": "(R)-carnitine + acetyl-CoA <=> CoA + O-acetyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30428", "l": "(2E,6E)-farnesyl diphosphate => (+)-germacrene D + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749215", "l": "MCM8 binds CDC6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28535", "l": "dTTP + H2O => diphosphate + dTMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35646", "l": "a (2R)-2-hydroxycarboxylate + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987007", "l": "p-STAT1 dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688838", "l": "RIPK3 binds STUB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607737", "l": "BCL10 oligomerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166038", "l": "GPI-bound CD14 binds LPS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2545253", "l": "Deacetylation of cohesin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182986", "l": "CBL-mediated ubiquitination of CIN85 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444100", "l": "PROT mediates L-proline uptake (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002466", "l": "Formation of allysine by LOX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730847", "l": "Hydrolysis of PIP2 by PLCG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33859", "l": "(2S-3S)-versiconal hemiacetal = H2O + versicolorin B", "d": []}, {"i": "EC:4.2.1.143", "l": "\"versicolorin B synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34391", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose = [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP", "d": []}, {"i": "EC:2.4.1.288", "l": "\"galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55524", "l": "H(+) + H2O + L-dopa + O2 = 3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": []}, {"i": "EC:4.1.1.107", "l": "\"3,4-dihydroxyphenylacetaldehyde synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676041", "l": "Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0017089", "l": "glycolipid transfer activity", "d": ["Removes a glycolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. A glycolipid is a compound usually containing 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034202", "l": "glycolipid floppase activity", "d": ["Catalysis of the movement of a glycolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.15", "l": "\"aminopeptidase Y\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65944", "l": "AH2 + CTP + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202459", "l": "Phosphorylation of Bcl10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848392", "l": "IL18BP binds IL18 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43127", "l": "guanosine(10) in tRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.105", "l": "\"rhomboid protease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698033", "l": "p-STAT5 translocates to nucleus downstream of mutant FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614461", "l": "Tetramerization of procollagen VI (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61455", "l": "H(+) + NADPH + O2 + oxytetracycline <=> 11a-hydroxy-oxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047349", "l": "D-ribitol-5-phosphate cytidylyltransferase activity", "d": ["Catalysis of the reaction: D-ribitol 5-phosphate + CTP = CDP-ribitol + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419083", "l": "Myosin phosphatase inactivation by ROCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140431", "l": "DNA-(abasic site) binding", "d": ["Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66781", "l": "6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O => N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878193", "l": "RUNX3 binds the JAG1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036319", "l": "mating-type M-factor pheromone receptor activity", "d": ["Combining with the mating-type peptide pheromone M-factor and transmitting the signal across the membrane to initiate a change in cell activity. M-factor is a nine-membered oligopeptide that consists of tyrosyl, threonyl, prolyl, lysyl, valyl, prolyl, tyrosyl, methionyl and methyl S-farnesylcysteinate residues joined in sequence, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Minus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209129", "l": "Ubiquitinated and phosphorylated ARM binds to and is degraded by the proteasome complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49452", "l": "a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O = 6-sulfo-alpha-D-quinovose + a 1,2-diacyl-sn-glycerol", "d": []}, {"i": "EC:3.2.1.199", "l": "\"sulfoquinovosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047759", "l": "butanal dehydrogenase activity", "d": ["Catalysis of the reaction: butanal + CoA + NAD(P)+ = butanoyl-CoA + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14441", "l": "acetyl-CoA + gentamicin C = CoA + H(+) + N(3)-acetylgentamycin C", "d": []}, {"i": "EC:2.3.1.60", "l": "\"gentamicin 3-N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047012", "l": "sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity", "d": ["Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31608", "l": "rhodopin => all-trans-lycopene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17000", "l": "3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol <=> 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032781", "l": "WWTR1 (TAZ) binds TEAD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166015", "l": "Association of LBP with LPS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199131", "l": "PVR binds CD226 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25640", "l": "H2O + NAD(+) + sulfoacetaldehyde <=> 2 H(+) + NADH + sulfoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34148", "l": "2-deoxy-L-scyllo-inosose + L-glutamine => 2-deoxy-scyllo-inosamine + 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53583", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20690", "l": "chlorogenate + H2O => (E)-caffeate + H(+) + L-quinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11555", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + H2O <=> 1-O-alkyl-sn-glycerol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9761421", "l": "CDH11 associates with catenins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0016631", "l": "enoyl-[acyl-carrier-protein] reductase activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD(P)+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52757", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28027", "l": "[thioredoxin]-disulfide + dUDP + H2O => [thioredoxin]-dithiol + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1176059", "l": "Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430190", "l": "p-SLP-76 binds NCK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56202", "l": "H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49900", "l": "5,10-dihydrophenazine-1,6-dicarboxylate + O2 = H2O2 + phenazine-1,6-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10708", "l": "alpha-D-glucose 1-phosphate + GTP + H(+) = diphosphate + GDP-D-glucose", "d": []}, {"i": "EC:2.7.7.34", "l": "\"glucose-1-phosphate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033406", "l": "UCC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UCC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25328", "l": "N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine <=> H(+) + phosphocholine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38164", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65949", "l": "a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2 => A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70041", "l": "3-dehydroteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033880", "l": "phenylacetyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: H2O + phenylglyoxylyl-CoA = CoA + H+ + phenylglyoxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949335", "l": "RUNX3:CBFB binds the ITGAL gene,(ITGA4 gene) promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36878", "l": "(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693540", "l": "MRN activates ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68784", "l": "(2Z,6Z)-farnesyl diphosphate = diphosphate + gamma-curcumene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51010", "l": "2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H(+) => 2 Fe(III)-[cytochrome cL] + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.41", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39813", "l": "18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5631885", "l": "PRDX1 overoxidizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870461", "l": "RABGGTA and RABGGTB bind (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102897", "l": "abietadienal hydroxylase activity", "d": ["Catalysis of the reaction: abietal + NADPH + O2 <=> abietate + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70386", "l": "3-oxosphinganine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888577", "l": "Synthesis of GABA by GAD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54947", "l": "3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3240957", "l": "Formation of PRC2-EZH2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12363", "l": "(2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine <=> 13-(2-methylcrotonoyloxy)lupanine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350058", "l": "Formation of CSL NCOR corepressor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61168", "l": "quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69913", "l": "adenosine(in) + 2 Na(+)(in) => adenosine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430347", "l": "MigFilin associates with Filamin and F-actin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60314", "l": "H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44113", "l": "hexadecanoyl-CoA + nonan-1-ol => CoA + nonyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674018", "l": "BRAP binds RAS:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018756", "l": "RHOH binds GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39488", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA => (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754974", "l": "ADK phosphorylates RBV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39080", "l": "(3S)-hydroxydodecanedioyl-CoA + NAD(+) => 3-oxododecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362465", "l": "GHBP binds GHR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167429", "l": "The receptor:G-protein complex  binds GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29209", "l": "a menaquinone(in) + dimethyl sulfide(out) + H2O(out) => a menaquinol(in) + dimethyl sulfoxide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18898", "l": "3,3',5'-triiodo-L-thyronine + A + H(+) + iodide => AH2 + L-thyroxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14453", "l": "4-(phosphooxy)-L-threonine + NAD(+) = (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948775", "l": "MKRN1 polyubiquitinates PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27519", "l": "H2O + sphing-4-enine 1-phosphate => phosphate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977375", "l": "CR1 binds C3bBb/C4bC2a (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140956", "l": "histone H3K79 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl79-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl79-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of up to three methyl group to the lysine residue at position 79 of the histone H3 protein, producing H3K79me3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38512", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296309", "l": "HCAR3 binds HCAR3 ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22798", "l": "ADP + D-hamamelose 2'-phosphate + H(+) => ATP + D-hamamelose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68206", "l": "1,2-dihexanoyl-3-octadecanoylglycerol + CoA => 1,2-dihexanoylglycerol + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675473", "l": "SH2B binds JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9612509", "l": "SGK phosphorylates SRF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34099", "l": "carboxynorspermidine + H(+) = CO2 + norspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433488", "l": "Phosphorylation of SHP2 by SFKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198621", "l": "AKT phosphorylates caspase-9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43077", "l": "erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854052", "l": "Formation of the SCF-FBXL7 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420975", "l": "Ca impermeable AMPA receptor ligand binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27613", "l": "formate + H(+) <=> CO2 + H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43483", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45523", "l": "phycoviolobilin-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11396", "l": "5-methyldeoxycytidine 5'-phosphate + ATP = 5-methyldeoxycytidine diphosphate + ADP", "d": []}, {"i": "EC:2.7.4.19", "l": "\"5-methyldeoxycytidine-5'-phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9793988", "l": "LUBAC ubiquitinates CFLAR at K351, K353 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805122", "l": "AURKB binds TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49154", "l": "dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine => dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62704", "l": "glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202709", "l": "JAM2 dimerises (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53609", "l": "4-hydroxyestrone + O2 => (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5658430", "l": "NF1 is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39005", "l": "a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+) => a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71849", "l": "LDH tetramer reduces PYR to LACT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30400", "l": "alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase] => alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68370", "l": "3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP => 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380233", "l": "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796617", "l": "MIB2 binds CFLAR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611277", "l": "P2RY12 binds P2RY12 antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51074", "l": "a phenol + an aryl sulfate => a phenol + an aryl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67376", "l": "glycyl-L-histidine + H2O = glycine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25533", "l": "ent-copalyl diphosphate => diphosphate + ent-cassa-12,15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36035", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177284", "l": "PKA phosphorylates PDE4B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42806", "l": "7,8-dihydromethanopterin + AH2 => 5,6,7,8-tetrahydromethanopterin + A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018851", "l": "alpha-pinene-oxide decyclase activity", "d": ["Catalysis of the reaction: alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69460", "l": "[thioredoxin]-dithiol + arsenic triglutathione + 2 H2O + S-adenosyl-L-methionine = [thioredoxin]-disulfide + 3 glutathione + H(+) + methylarsonous acid + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213241", "l": "Formation of nonameric complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.26", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002162", "l": "dystroglycan binding", "d": ["Binding to dystroglycan, a glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696947", "l": "USP47 deubiquitinates POLB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9759158", "l": "SQSTM1 oligomerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446211", "l": "Flipping of dolichyl-phosphate-glucose into the ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210285", "l": "Trans-homophilic interaction of PECAM-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432513", "l": "CLK is phosphorylated by DCO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63803", "l": "GDP-alpha-D-mannose <=> GDP-beta-L-gulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52428", "l": "12-oxo-leukotriene B4 + H(+) + NADH = 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20572", "l": "H2O + L-arginine <=> L-ornithine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73600", "l": "CDP(in) + CTP(out) => CDP(out) + CTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73513", "l": "CO2 + formaldehyde + pilosin + succinate => 2-oxoglutarate + 8-hydroxysalvigenin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63858", "l": "(2R)-2-hydroperoxytetradecanoate => O2 + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62849", "l": "GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33476", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41274", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25789", "l": "4-hydroxy-2-oxoheptanedioate => pyruvate + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41703", "l": "1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851436", "l": "CFHR dimers bind C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857555", "l": "EGFR phosphorylates GPNMB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56705", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 => 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32986", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54745", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.-", "l": "\"With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-555065", "l": "Formation of clathrin coated vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63888", "l": "hexadecanoyl-CoA + sphinga-4E,14Z-dienine = CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099615", "l": "(D)-2-hydroxyglutarate-pyruvate transhydrogenase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxyglutarate + pyruvate = alpha-ketoglutarate + D-lactate, with FAD functioning as an intermediate hydrogen acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20024", "l": "2-oxoglutarate + deoxyamidinoproclavaminate + O2 <=> amidinoproclavaminate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.103", "l": "\"physarolisin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56941", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => 2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69183", "l": "ADP + thiamine diphosphate <=> AMP + thiamine triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47542", "l": "NADP(+) + ursodeoxycholate => 7-oxolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008783", "l": "agmatinase activity", "d": ["Catalysis of the reaction: agmatine + H2O = putrescine + urea."]}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0050737", "l": "O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the transfer of a hydroxycinnamoyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47764", "l": "S-adenosyl-L-methionine + uridine(1369) in 16S rRNA = 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008396", "l": "oxysterol 7-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296326", "l": "HCAR1 binds LACT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38320", "l": "chorismate + H2O => (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.576939455547432", "identifiers": [{"i": "GO:0016822", "l": "hydrolase activity, acting on acid carbon-carbon bonds", "d": ["Catalysis of the hydrolysis of any acid carbon-carbon bond."]}, {"i": "EC:3.7.-.-", "l": "\"Acting on carbon-carbon bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940100", "l": "CDK1 phosphorylates VCPIP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804276", "l": "ATM phosphorylates TTC5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450348", "l": "Activated human JNKs migrate to nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57070", "l": "3-oxoisoapionate 4-phosphate + ADP + H(+) => 3-oxoisoapionate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23215", "l": "H2O + N-acetyl-beta-alanine <=> acetate + beta-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51500", "l": "ATP + N-acetyl-D-muramate = ADP + H(+) + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708557", "l": "FBXL17 binds BACH1:MAFK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48068", "l": "ganglioside GM2 (d18:1(4E)) + H2O = ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32615", "l": "(6E)-8-oxogeraniol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247836", "l": "Retromer recycles WLS to the Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654511", "l": "FGFRL1 dimer binds FGFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030792", "l": "methylarsonite methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029473", "l": "Branching and elongation of mother and daughter filaments (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35530", "l": "H(+) + N-ethylmaleimide + NADH <=> N-ethylsuccinimide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71235", "l": "[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22554", "l": "adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+) => 3'-phosphoadenylyl sulfate + an alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22191", "l": "an (R)-2-haloacid + H2O <=> a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45986", "l": "9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+) => 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375138", "l": "CDO binds BOC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69280", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate = 3-hydroxypropyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465924", "l": "OPN1LW binds 11cRAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30486", "l": "N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40843", "l": "FAD + H(+) + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33665", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11680", "l": "ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate", "d": []}, {"i": "EC:6.3.5.2", "l": "\"GMP synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54925", "l": "(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75779", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoate + H2O = (10S)-hydroxy-(6Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38875", "l": "uridine(2604) in 23S rRNA = pseudouridine(2604) in 23S rRNA", "d": []}, {"i": "EC:5.4.99.21", "l": "\"23S rRNA pseudouridine(2604) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46116", "l": "2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035478", "l": "chylomicron binding", "d": ["Binding to a chylomicron, a large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68301", "l": "L-seryl-[protein] + tetradecanoyl-CoA => CoA + O-tetradecanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19632", "l": "D-threo-isocitrate + NADP(+) <=> 2-oxoglutarate + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768782", "l": "miR-224 represses NPAS4 mRNA translation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952371", "l": "MDM2 binds RUNX3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333051", "l": "RPA1 binds HSF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65349", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA => 3-oxochol-4,6-dien-24-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60192", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74388", "l": "formamide(out) => formamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58123", "l": "ATP + L-seryl-[protein] <=> 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38397", "l": "(9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+) => 1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852317", "l": "PLK1 phosphorylates GTSE1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0003955", "l": "NAD(P)H dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35290", "l": "ATP + chloramphenicol(in) + H2O <=> ADP + chloramphenicol(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71420", "l": "3,3',5-triiodo-L-thyronine(out) + L-tyrosine(in) => 3,3',5-triiodo-L-thyronine(in) + L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218847", "l": "PAK2 binds NCK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168324", "l": "Conformation change in hemagglutinin freeing the fusion peptide of HA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254291", "l": "ERBB4s80 binds STAT5A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.43", "l": "\"lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63717", "l": "losartan + UDP-alpha-D-glucuronate => losartan-1-N-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2059926", "l": "NPHP4 protein binds LATS proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55314", "l": "1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033294", "l": "ectoine binding", "d": ["Binding to ectoine, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56714", "l": "H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74516", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B => aspoquinolone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033922", "l": "peptidoglycan beta-N-acetylmuramidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing N-acetylmuramic residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176298", "l": "Activation of claspin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41150", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803892", "l": "SFN dimer binds BAX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693347", "l": "HTR1A binds 5HT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27745", "l": "2'-deoxyadenosine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60670", "l": "(1R,3R)-chrysanthemal + H(+) + NADH => (R,R)-chrysanthemol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47076", "l": "17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH = 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49187", "l": "chlorophyllide a + H(+) + H2O <=> 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62094", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928616", "l": "Activated ROCK phosphorylates MRLCs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49955", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate <=> 5,10-dihydrophenazine 1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-984689", "l": "Kinesin-7 is a dimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33912", "l": "an N-alkylglycine + H2O + O2 => an alkylamine + glyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.372", "l": "\"D/L-glyceraldehyde reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15270", "l": "L-xylo-hex-3-ulonolactone => H(+) + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928614", "l": "EFNB:GRB4 binds GIT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418904", "l": "A1 and A3 receptors bind adenosine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57805", "l": "1-chloro-3-nitrobenzene + NADH + O2 => 4-chlorocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74238", "l": "H2O + L-threonyl-tRNA(Ser) <=> L-threonine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036131", "l": "prostaglandin D2 11-ketoreductase activity", "d": ["Catalysis of the reaction: prostaglandin D2 + H+ + NADPH = 11-epi-prostaglandin F2alpha + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434989", "l": "SEMA7A binds to PLXNC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63917", "l": "5-fluorouridine + ATP => 5-fluorouridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37909", "l": "(8E,10S)-10-hydroperoxy-octadeca-8-enoate => (9Z)-octadecenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419428", "l": "S1PR2-5 bind S1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47675", "l": "H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5660663", "l": "Caspase-8 cleaves IL1B precursor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295632", "l": "PPA2A dephosphorylates SPRY2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2129362", "l": "Fibrillin microfibril assembly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14572", "l": "propane-1,2-diol <=> H2O + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047092", "l": "27-hydroxycholesterol 7-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52034", "l": "(+)-7-isojasmonate + L-isoleucine => H2O + L-isoleucine-(+)-7-isojasmonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46715", "l": "pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264435", "l": "Dissociation of the COP1-p53 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67896", "l": "a 3'-end uridylyl-adenosine-RNA = a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67765", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015113", "l": "nitrite transmembrane transporter activity", "d": ["Enables the transfer of nitrite (NO2-) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390909", "l": "HRH2 binds hist (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72592", "l": "D-glucuronate(out) + H(+)(out) => D-glucuronate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56620", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O = 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16763", "l": "5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+) => chlorohydroquinone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981713", "l": "C4b binds to cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13022", "l": "H(+) + NADH + O2 + vanillate => 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14794", "l": "2-hydroxyadipate + NAD(+) => 2-oxoadipate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11430", "l": "D-glucono-1,5-lactone + H2O2 => beta-D-glucose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621370", "l": "SYK autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65134", "l": "CO2 + H2O + preaustinoid A2 + succinate => 2-oxoglutarate + O2 + preaustinoid A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169402", "l": "ISGylation of E2 conjugating enzymes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4411402", "l": "Activation of NLK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.163", "l": "\"1,6-alpha-D-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29021", "l": "D-galactose(out) + H(+)(out) => D-galactose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38439", "l": "(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48761", "l": "L-threitol + NAD(+) => H(+) + L-erythrulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033842", "l": "N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16378", "l": "(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] => biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45419", "l": "11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O <=> 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849055", "l": "PTK6 binds ARHGAP35 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29519", "l": "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.257", "l": "\"GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668404", "l": "TNFA binds TNFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60694", "l": "(E)-non-2-enoate + 2 H(+) + NADPH => (E)-non-2-enal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371527", "l": "HSF1 trimer translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605595", "l": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646685", "l": "Aggresome dissociates from dynein and microtubule (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17852", "l": "(3R)-3-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53310", "l": "16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15728", "l": "1,5-anhydro-D-fructose <=> ascopyrone M + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21801", "l": "all-trans-antheraxanthin + L-ascorbate => all-trans-zeaxanthin + H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64115", "l": "an N-acyl-L-phenylalanine + H2O <=> a fatty acid + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11806", "l": "an aromatic carboxylate + 2 H(+) + NADH => an aromatic aldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32420", "l": "(1S,2R,4R)-neoisodihydrocarveol + NAD(+) => (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28668", "l": "H(+) + hydroxyacetone + NADH => (S)-propane-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102676", "l": "avenasterol-desaturase activity", "d": ["Catalysis of the reaction: avenasterol + O2 + NADPH + H+ <=> 5-dehydroavenasterol + 2 H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35575", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] = (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.18", "l": "\"lysine 6-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50316", "l": "ethyl octadecanoate + H2O = ethanol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804383", "l": "PRMT5 methylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22664", "l": "2 1-O-(trans-sinapoyl)-beta-D-glucose = 1,2-di-O-sinapoyl beta-D-glucose + D-glucose", "d": []}, {"i": "EC:2.3.1.103", "l": "\"sinapoylglucose--sinapoylglucose O-sinapoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8957241", "l": "TP73 tetramer translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052766", "l": "mannoside alpha-1,4-mannosidase activity", "d": ["Catalysis of the hydrolysis of the alpha-(1->4) linkage of the terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29630", "l": "alpha-maltohexaose + beta-maltose <=> alpha-maltoheptaose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627369", "l": "SEPT4 binds XIAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869568", "l": "NPM1 binds TFAP2A homodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-376886", "l": "Efflux of glucose and orthophosphate from the endoplasmic reticulum (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15006", "l": "2-oxoglutarate + gibberellin A1 + O2 => CO2 + gibberellin A8 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102919", "l": "5,6-dimethylbenzimidazole synthase activity", "d": ["Catalysis of the reaction: FMNH2 + O2 <=> 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialuric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030780", "l": "12-hydroxydihydrochelirubine 12-O-methyltransferase activity", "d": ["Catalysis of the reaction: 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydromacarpine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71375", "l": "2 Na(+)(out) + testosterone 17-sulfate(out) = 2 Na(+)(in) + testosterone 17-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814088", "l": "SYS1 binds AcM-ARFRP1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417829", "l": "P2RY12 binds ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0008121", "l": "ubiquinol-cytochrome-c reductase activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50824", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 = 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45338", "l": "[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA => (9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.099567117513104", "identifiers": [{"i": "GO:0034061", "l": "DNA polymerase activity", "d": ["Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987120", "l": "JAK1 binds IFNLR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008980", "l": "propionate kinase activity", "d": ["Catalysis of the reaction: ATP + propanoate = ADP + propanoyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38095", "l": "gamma-tocotrienol + S-adenosyl-L-methionine = alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53183", "l": "D-erythrose <=> D-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389083", "l": "Autophosphorylation of PDGF alpha receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204465", "l": "Basigin interacts with CD43 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374899", "l": "Release of noradrenaline  at the synapse (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983518", "l": "IL35 binds IL6ST:IL6ST receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665706", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793485", "l": "PRKN polyubiquitinates RIPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800298", "l": "HGF dimer binds MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54950", "l": "(2E,5Z)-dodecadienoyl-[ACP] + H2O => (3R)-hydroxy-(5Z)-dodecenoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17733", "l": "acetylenedicarboxylate + H(+) + H2O = CO2 + pyruvate", "d": []}, {"i": "EC:4.1.1.78", "l": "\"acetylenedicarboxylate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203700", "l": "eNOS translocation from Golgi to Caveolae (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17236", "l": "L-fucose <=> L-fuculose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48286", "l": "globoside NOR1 (d18:1(4E)) + H(+) + UDP => globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48076", "l": "a primary alcohol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685838", "l": "CX3 complex binds D-loop structures (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28229", "l": "(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13759", "l": "(Z)-desulfoglucotropeolin + UDP => (Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55701", "l": "an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O => an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990538", "l": "xylan O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + a xylan= CoA + an acetylated xylan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63576", "l": "ecdysone 22-phosphate + H2O = ecdysone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71826", "l": "3,3'-diiodo-L-thyronine(out) <=> 3,3'-diiodo-L-thyronine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74691", "l": "2 a 2,3-di-O-phytanyl-sn-glycerophospholipid + 2 AH2 + 4 S-adenosyl-L-methionine = 4 5'-deoxyadenosine + 2 A + a glycerol dibiphytanyl glycerol tetraether phospholipid + 4 H(+) + 4 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.24", "l": "\"lipopolysaccharide heptosyltransferase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12792", "l": "an alditol + NADP(+) <=> an aldose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12456", "l": "CTP + D-ribitol 5-phosphate + H(+) = CDP-L-ribitol + diphosphate", "d": []}, {"i": "EC:2.7.7.40", "l": "\"D-ribitol-5-phosphate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19636", "l": "(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) <=> (5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54574", "l": "a pseudouridine in tRNA => a uridine in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38772", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11365", "l": "ATP + H2O + pyruvate => AMP + 2 H(+) + phosphate + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913451", "l": "IL3RB is phosphorylated on Ser-585 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63595", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69184", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate", "d": []}, {"i": "EC:2.5.1.155", "l": "\"phosphoglycerol geranylfarnesyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47904", "l": "ATP + N-(acetyl)-sphing-4-enine = ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045435", "l": "lycopene epsilon cyclase activity", "d": ["Catalysis of the cyclization of an epsilon ring at one end of the lycopene molecule (psi, psi-carotene) to form delta-carotene (epsilon, psi-carotene)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9725206", "l": "IgE binds FCERI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60117", "l": "2-oxoglutarate + methylphosphonate + O2 => CO2 + hydroxymethylphosphonate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52554", "l": "3-dehydro-4-O-phospho-L-erythronate + ADP + H(+) => 3-dehydro-L-erythronate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.58", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15821", "l": "2 A + glycine = 2 AH2 + CO2 + hydrogen cyanide", "d": []}, {"i": "EC:1.4.99.5", "l": "\"glycine dehydrogenase (cyanide-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22384", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5658438", "l": "SPRED dimer binds NF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71711", "l": "H(+)(out) + L-tyrosylglycine(out) = H(+)(in) + L-tyrosylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56933", "l": "androst-5-en-3beta,17beta-diol + NAD(+) => 17beta-hydroxy-androst-5-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20072", "l": "(Z)-phenylacetaldehyde oxime <=> H2O + phenylacetonitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44564", "l": "4-hydroxybenzoate + all-trans-decaprenyl diphosphate = 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51205", "l": "6-trans-leukotriene B4 + NADP(+) => 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008998", "l": "ribonucleoside-triphosphate reductase activity", "d": ["Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062122", "l": "histone H3K37 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 37) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 37). This reaction is the addition of a methyl group to the lysine residue at position 37 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426032", "l": "DAG is metabolized by DAGL to 2-AG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442387", "l": "ZIP8 mediates zinc influx into cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55849", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59271", "l": "A + H2O + N(6)-methyl-L-lysyl-[protein] <=> AH2 + formaldehyde + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034007", "l": "S-linalool synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + H2O = (S)-linalool + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54148", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene = 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65664", "l": "citrate(out) + 4 Na(+)(out) = citrate(in) + 4 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12975", "l": "2 ADP => AMP + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56171", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863718", "l": "AGFG1 binds VAMP7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0051117", "l": "ATPase binding", "d": ["Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015048", "l": "phthalate dioxygenase reductase activity", "d": ["Catalysis of the transfer of electrons between pyridine nucleotides (obligatory two-electron carriers) and hemes or (2Fe-2S) centers (obligatory one-electron carriers) in respiration, photosynthesis, and many oxygenase systems."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.61", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46191", "l": "an aliphatic nitrile + 2 H2O <=> a carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191636", "l": "Phosphorylation of Cx43 by c-src (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9714580", "l": "SLC6A3 binds DRIs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27795", "l": "(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate => all-trans-heptaprenyl diphosphate + 4 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14706", "l": "2 CoA + NADP(+) => CoA-disulfide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009541", "l": "ESR1 binds to TFF1 gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60310", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627056", "l": "Procaspase 9 forms dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54416", "l": "5alpha-campestan-3-one + NADP(+) = campest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031789", "l": "G protein-coupled acetylcholine receptor binding", "d": ["Binding to a G protein-coupled acetylcholine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63505", "l": "daunorubicin + H(+) + NADPH => 13-dihydrodaunorubicin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4167511", "l": "HLCS biotinylates ACACB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878056", "l": "RUNX1:CBFB binds EP300 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48693", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16397", "l": "2 D-glucopyranose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate", "d": []}, {"i": "EC:2.7.1.41", "l": "\"glucose-1-phosphate phosphodismutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18897", "l": "3,3',5'-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-thyroxine", "d": []}, {"i": "EC:1.21.99.3", "l": "\"thyroxine 5-deiodinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44107", "l": "decanal + H2O + NAD(+) <=> decanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67512", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19465", "l": "NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204813", "l": "Interaction of Tie2 and Grb14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61824", "l": "pregnenolone + UDP-alpha-D-glucose = H(+) + pregnenolone 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29863", "l": "AMP + GTP = ADP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55832", "l": "cortisone + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112282", "l": "CAMK4 enters the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53880", "l": "ADP-alpha-D-glucose + D-glucose 6-phosphate = ADP + alpha,alpha-trehalose 6-phosphate + H(+)", "d": []}, {"i": "EC:2.4.1.347", "l": "\"alpha,alpha-trehalose-phosphate synthase (ADP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32649", "l": "erythromycin A + H(+) + S-adenosyl-L-homocysteine => erythromycin C + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688294", "l": "SIRT5 deacetylates Cytochrome C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56911", "l": "(7S)-O-acetylsalutaridinol <=> acetate + H(+) + thebaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420121", "l": "SFKs phosphorylate PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68611", "l": "Formation of ORC(1-5) complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46635", "l": "7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH <=> 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42384", "l": "4,4'-diaponeurosporenal + H2O + NAD(+) = 4,4'-diaponeurosporenoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023171", "l": "Insulin secretory granule translocates across the cortical actin network (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990276", "l": "RNA 5'-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the 5'-gamma-phosphate in an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51757", "l": "a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4,6-diprenylphloroglucinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69607", "l": "acetyl-CoA + N-terminal L-methionyl-[tubulin] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin]", "d": []}, {"i": "EC:2.3.1.308", "l": "\"tubulin N-terminal N-acetyltransferase NAT9\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36811", "l": "acetyl-CoA + GDP-alpha-D-perosamine = CoA + GDP-N-acetyl-alpha-D-perosamine + H(+)", "d": []}, {"i": "EC:2.3.1.227", "l": "\"GDP-perosamine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62680", "l": "naphtopyrone YWA1 = H(+) + H2O + norrubrofusarin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23417", "l": "(2R)-O-phospho-3-sulfolactate + H2O => (2R)-3-sulfolactate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852010", "l": "BTNL2 binds activated T cells surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.1", "l": "\"purine-nucleoside phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17639", "l": "hop-22(29)-ene => squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804099", "l": "HMGB1 binds LTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16944", "l": "N-acetylindoxyl + O2 <=> H2O + N-acetylisatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67604", "l": "H2O + N(6)-methyl-dATP = diphosphate + H(+) + N(6)-methyl-dAMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53056", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10257", "l": "[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O => [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55312", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59082", "l": "2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+) => bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54171", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59188", "l": "L-histidine = D-histidine", "d": []}, {"i": "EC:5.1.1.24", "l": "\"histidine racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35955", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B = 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.118", "l": "\"tryprostatin B 6-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350578", "l": "NQO1 interaction with ODC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44574", "l": "2-all-trans-heptaprenylphenol + CO2 => 4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809663", "l": "Formation of hair keratin fibres (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37941", "l": "(8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156910", "l": "Formation of eEF1B complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693092", "l": "Unknown deacetylase deacetylates 7K-BACE1(46-501) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14344", "l": "2-oxoglutarate + glyoxylate + H(+) <=> 2-hydroxy-3-oxoadipate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25774", "l": "(2S,3S)-3-hydroxyasparagine + CO2 + succinate => 2-oxoglutarate + L-asparagine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102600", "l": "cytochrome P450 dependent 12,13beta-epoxy-beta-amyrin hydroxylase activity", "d": ["Catalysis of the reaction: 12,13beta-epoxy-beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793666", "l": "MDM2 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.327400668044291", "identifiers": [{"i": "GO:0008047", "l": "enzyme activator activity", "d": ["Binds to and increases the activity of an enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25354", "l": "H2O + L-cysteinyl-tRNA(Pro) <=> H(+) + L-cysteine + tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14741", "l": "4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH4(+)", "d": []}, {"i": "EC:3.5.1.67", "l": "\"4-methyleneglutaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22030", "l": "CoA + taxa-4(20),11-dien-5alpha-yl acetate => acetyl-CoA + taxa-4(20),11-dien-5alpha-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39844", "l": "1,3-diacyl-sn-glycerol + an acyl-CoA => a triacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004860", "l": "protein kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a protein kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65771", "l": "a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0030555", "l": "RNA modification guide activity", "d": ["Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404200", "l": "IGF1,2 binds IGF1R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212356", "l": "Formation of CSL-NICD coactivator complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37513", "l": "1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55276", "l": "9-cis-retinol + tetradecanoyl-CoA = 9-cis-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28226", "l": "(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.149", "l": "\"5-epiaristolochene 1,3-dihydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0017150", "l": "tRNA dihydrouridine synthase activity", "d": ["Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74462", "l": "1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) <=> 1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63611", "l": "apelin-17 + H2O <=> apelin-16 + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10203", "l": "butanoate + NAD(+) <=> (2E)-2-butenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004338", "l": "glucan exo-1,3-beta-glucosidase activity", "d": ["Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29604", "l": "benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] => 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37405", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73688", "l": "dAMP(out) + phosphate(in) => dAMP(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11046", "l": "a halide anion + glycolate + H(+) => a haloacetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59721", "l": "D-maltohexaono-1,5-lactone + H2O => D-maltohexaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961863", "l": "E2F1 binds the DHFR gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73497", "l": "an 8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => an 8-hydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247843", "l": "secretion of WNT ligands (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21224", "l": "CDP-choline + sphing-4-enine = CMP + H(+) + sphing-4-enine-phosphocholine", "d": []}, {"i": "EC:2.7.8.10", "l": "\"sphingosine cholinephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31473", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP => beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0055106", "l": "ubiquitin-protein transferase regulator activity", "d": ["Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193656", "l": "p75NTR interacts with RIP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.12", "l": "\"ABC-type L-arabinose transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23065", "l": "an alkanesulfonate + FMNH2 + O2 => an aldehyde + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14084", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate <=> D-glyceraldehyde 3-phosphate + indole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56537", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47727", "l": "glutathione <=> 5-oxo-L-proline + L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59494", "l": "(2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate => (2E)-geranyl diphosphate + L-tryptophyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5617828", "l": "TRIP11:IFT20 dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20499", "l": "an N-acetyl-2-arylethylamine + CoA + H(+) => a 2-arylethylamine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43244", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21805", "l": "ATP + myo-inositol => 1D-myo-inositol 3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49623", "l": "D-erythritol 1-phosphate + NADP(+) <=> D-erythrulose 1-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200396", "l": "Creatine transport across the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322427", "l": "Beta-catenin recruits CBP/p300 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18462", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74730", "l": "Insulin degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18502", "l": "ergosterol + NADP(+) => ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65685", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine => a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47518", "l": "isochenodeoxycholate + NAD(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40241", "l": "AMP + diphosphate + dodecanedioyl-CoA => ATP + CoA + dodecanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52591", "l": "choloyl-CoA + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13183", "l": "ADP + H(+) + nitrate(in) + phosphate => ATP + H2O + nitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218847", "l": "PAK2 binds NCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043472", "l": "IgD binding", "d": ["Binding to an immunoglobulin of a D isotype."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332356", "l": "CAMK2 binds MAP3K7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.863640214551324", "identifiers": [{"i": "GO:0019777", "l": "Atg12 transferase activity", "d": ["Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y = Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages."]}, {"i": "REACT:R-HSA-5681999", "l": "ATG10 transfers ATG12 from ATG7 to ATG10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.28", "l": "\"phenylethanolamine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24992", "l": "L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19232", "l": "AMP + an aromatic aldehyde + diphosphate + NADP(+) <=> an aromatic carboxylate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-481007", "l": "Exocytosis of platelet alpha granule contents (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19425", "l": "H(+) + imidazole-4-acetate + NADH + O2 = 5-hydroxyimidazole-4-acetate + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.5", "l": "\"imidazoleacetate 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61627", "l": "2-oxoglutarate + cadaverine <=> 5-aminopentanal + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72142", "l": "estrone 3-sulfate(in) + H(+)(out) <=> estrone 3-sulfate(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66792", "l": "N-methyl-D-dopa + O2 = (3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43154", "l": "H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine => adenosine(58) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66630", "l": "(2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2 => (2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31278", "l": "(S)-3-hydroxy-2-methylpropanoate + NAD(+) <=> (S)-methylmalonate semialdehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55477", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32814", "l": "benzoate(in) <=> benzoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43598", "l": "3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde => (3R)-3-hydroxy-8'-apo-beta-carotenal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190261", "l": "FGFR3c binds to FGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20187", "l": "an N-acylneuraminate + CMP + H(+) => a CMP-N-acyl-beta-neuraminate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799466", "l": "TP53I3 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0032841", "l": "calcitonin binding", "d": ["Binding to calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56711", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35582", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8 <=> anthocyanin A11 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3857336", "l": "CEBPB homodimerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682983", "l": "ATM phosphorylates WHSC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592387", "l": "Fibulin binds elastic fibres (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404134", "l": "RBP4:atROL binds TTR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9652264", "l": "ERBB2 binds TKIs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954082", "l": "E2F6 binds the PRC1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12707", "l": "[protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine => [protein]-L-isoaspartate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69458", "l": "3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+) => 3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045735", "l": "nutrient reservoir activity", "d": ["Functions in the storage of nutritious substrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55835", "l": "cortisone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52261", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide c => a bacteriochlorophyllide e + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706298", "l": "Active FLT3 binds to CSK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467633", "l": "AGRN binds LRP4:MUSK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614662", "l": "FOXO1,FOXO3,(FOXO4) bind FASLG gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551648", "l": "SUMOylation of TDG with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417829", "l": "P2RY12 binds ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32693", "l": "(E)-beta-ocimene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707505", "l": "Hemes bind to CLEC1B dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67140", "l": "L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2 = H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004319", "l": "enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40188", "l": "(2E)-octenoyl-CoA + H2O => (3R)-hydroxyoctanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801101", "l": "RABGGTA binds RABGGTB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49909", "l": "(R)-carnitine(out) + O-acetyl-(R)-carnitine(in) => (R)-carnitine(in) + O-acetyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43967", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA <=> 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021480", "l": "NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51312", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008184", "l": "glycogen phosphorylase activity", "d": ["Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696997", "l": "USP24 deubiquitinates DDB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.107", "l": "\"sanguinarine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395764", "l": "atREs binds to nascent CM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40202", "l": "hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44374", "l": "Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide => Cr(6+) + 2 NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34948", "l": "(Z)-3-aminoacrylate + H(+) + H2O => 3-oxopropanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112514", "l": "JAK activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004665", "l": "prephenate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + prephenate = (4-hydroxyphenyl)pyruvate + CO2 + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33996", "l": "gamma-L-glutamyl-butirosin B => 5-oxo-L-proline + butirosin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69302", "l": "benzyl isothiocyanate + sulfate => (Z)-phenyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25489", "l": "(2E)-geranyl diphosphate => (1S,5S)-alpha-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33584", "l": "L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate => 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351936", "l": "Caspase-mediated cleavage of claspin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849857", "l": "KLK5 cleaves and activates CELA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65146", "l": "CO2 + H2O + preaustinoid A + succinate => 2-oxoglutarate + berkeleyone A + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63379", "l": "an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928578", "l": "EPH receptors autophosphorylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63056", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine = 5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23228", "l": "L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)", "d": []}, {"i": "EC:1.14.13.59", "l": "\"L-lysine N(6)-monooxygenase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626753", "l": "H2O2 oxidizes Cys residues to form Cys-sulfenic acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052825", "l": "inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate."]}, {"i": "REACT:R-HSA-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9658253", "l": "RAS:GTP binds PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.169", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66511", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63978", "l": "AH2 + pyriculariol => A + dihydropyriculariol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106309", "l": "progesterone 21-hydroxylase activity", "d": ["Catalysis of the reaction: O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."]}, {"i": "RHEA:50304", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66295", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose <=> an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57088", "l": "an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55355", "l": "all-trans-retinol <=> 13-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938938", "l": "RUNX1 and ELF1 bind the IL3 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55517", "l": "11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] => 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102608", "l": "tetracenomycin B3 8-O-methyl transferase activity", "d": ["Catalysis of the reaction: tetracenomycin B3 + S-adenosyl-L-methionine <=> tetracenomycin E + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.70", "l": "\"7-deoxycylindrospermopsin hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611751", "l": "β1,2-agonists bind ADRB1,2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25659", "l": "(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] => (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76031", "l": "2 H2O2 => O2 + 2 H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23993", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43011", "l": "D-serine <=> 2-aminoprop-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34737", "l": "an N-acylsphinganine + CoA + H(+) => a fatty acyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64789", "l": "(E)-cinnamate + ATP + CoA => (E)-cinnamoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676254", "l": "Formation of the MLL3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043864", "l": "indoleacetamide hydrolase activity", "d": ["Catalysis of the reaction: indole-3-acetamide + H2O = indole-3-acetate + NH3. Indole-3-acetamide is known as IAM and indole-3-acetate as IAA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196417", "l": "Reduction of desmosterol to cholesterol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.47", "l": "\"glucose 1-dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693540", "l": "MRN activates ATM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047668", "l": "amygdalin beta-glucosidase activity", "d": ["Catalysis of the reaction: (R)-amygdalin + H2O = (R)-prunasin + D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55610", "l": "a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64032", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40737", "l": "2 D-glucose + gypenoside LXXV => (20S)-ginsenoside Rb1 + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60240", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41020", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol => 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216045", "l": "Collagen type I binds integrin alpha11beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42065", "l": "ATP + GTP => 2',3'-cGAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701507", "l": "PTPN6 dephosphorylates JAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10231", "l": "citrate <=> cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052862", "l": "glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group", "d": ["Catalysis of the endohydrolysis of (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65381", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9624798", "l": "LBR binds KPNB1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16669", "l": "H2O + NAD(+) + xanthine = H(+) + NADH + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21376", "l": "3-(4-hydroxyphenyl)pyruvate + O2 = (S)-4-hydroxymandelate + CO2", "d": []}, {"i": "EC:1.13.11.46", "l": "\"4-hydroxymandelate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31477", "l": "H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP => soyasapogenol B + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607722", "l": "Active NIK phosphorylates IKKA dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63174", "l": "(25R)-3-oxocholest-4-en-26-oyl-CoA => (25S)-3-oxocholest-4-en-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40566", "l": "dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 <=> dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199046", "l": "Ligands bind L-selectin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15591", "l": "4-hydroxyphenylglyoxylate + L-glutamate => 2-oxoglutarate + D-4-hydroxyphenylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57317", "l": "ATP + cytidine 5'-diphosphoramidate => ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451758", "l": "p85 associates with both p-Nephrin and CD2AP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340214", "l": "CYGB binds O2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-555065", "l": "Formation of clathrin coated vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71793", "l": "(R)-lactate(out) + H(+)(out) => (R)-lactate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12734", "l": "CO2 + diphosphate + nicotinate beta-D-ribonucleotide => 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74519", "l": "1-(3-O-sulfo-beta-D-galactosyl)-ceramide + H2O = beta-D-Gal-(1<->1')-Cer + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1470010", "l": "Dimerization of STATs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:1901474", "l": "azole transmembrane transporter activity", "d": ["Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052654", "l": "L-leucine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.281", "l": "\"GDP-4-dehydro-6-deoxy-D-mannose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679205", "l": "ULK1 phosphorylates Beclin-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250272", "l": "TXNIP binds NLRP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57714", "l": "4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP => (E)-sinapaldehyde + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864595", "l": "TFAP2B homodimer binds YEATS4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.378", "l": "\"L-rhamnose 1-dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17877", "l": "a catechol + S-adenosyl-L-methionine = a guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.6", "l": "\"catechol O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44260", "l": "2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA = 4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654623", "l": "Activated FGFR3 binds FRS3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797957", "l": "BET translocates from mitochondrial matrix to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63636", "l": "a medium-chain fatty acyl-AMP + holo-[ACP] = a medium-chain fatty acyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64248", "l": "decanoyl-CoA + glycine = CoA + H(+) + N-decanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14255", "l": "diphosphate + GDP + H(+) => guanosine 3',5'-bis(diphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047974", "l": "guanosine deaminase activity", "d": ["Catalysis of the reaction: guanosine + H2O = xanthosine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69680", "l": "apigenin 7-O-beta-D-glucoside + H2O => apigenin + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65172", "l": "(3Z,5E)-dodecadienoyl-CoA + H2O = (3Z,5E)-dodecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354087", "l": "Recruitment of GRB2 to p-PTK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66836", "l": "4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase] = asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66962", "l": "beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70635", "l": "H2O + N(6)-octanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-octanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70086", "l": "hydroxyclavatol <=> H2O + o-quinone methide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35673", "l": "(1'S,5'S)-averufin + H2O => (S)-5'-oxoaverantin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789114", "l": "Hydroxyl radical reacts with the base and sugar moiety of DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730835", "l": "Autophosphorylation of PKC-theta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13391", "l": "(2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein] => glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55573", "l": "4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine => 4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18866", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA => (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706304", "l": "Active FLT3 binds to GRAP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17082", "l": "(E)-isoeugenol + S-adenosyl-L-methionine => (E)-isomethyleugenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43369", "l": "dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668714", "l": "RAC1:GTP binds NOX1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31758", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + H2O <=> 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050026", "l": "L-glycol dehydrogenase activity", "d": ["Catalysis of the reaction: an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50720", "l": "FMNH2 + methanesulfinate + O2 = FMN + H(+) + H2O + methanesulfonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52699", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose <=> a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210292", "l": "Interaction of DAP12 and TREM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66281", "l": "solanidine + UDP-alpha-D-glucose => H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25930", "l": "3-methylquinolin-2(1H)-one + AH2 => 3-methylquinoline + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44344", "l": "ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate = ADP + dapdiamide A + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045156", "l": "electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity", "d": ["Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33260", "l": "4-aminoimidazole + H(+) + 2 H2O => N-formimidoylglycine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44763", "l": "2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69048", "l": "H2O + hexano-6-lactone = 6-hydroxyhexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10731", "l": "GDP-6-deoxy-alpha-D-talose + NAD(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428909", "l": "Activated TP receptor binds G-protein  G13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15014", "l": "3alpha(S)-strictosidine + H2O => secologanin + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0038132", "l": "neuregulin binding", "d": ["Binding to a neuregulin, a member of the EGF family of growth factors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64701", "l": "1-phenylethanol + NAD(+) => acetophenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102202", "l": "soladodine glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + solasodine <=> UDP + solasodine 3-O-beta-D-glucopyranoside + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16352", "l": "AH2 + chlorate <=> A + chlorite + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74827", "l": "UDP-alpha-D-galacturonate(in) + UMP(out) = UDP-alpha-D-galacturonate(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61704", "l": "ATP + holo-[peptidyl-carrier protein] + L-serine = AMP + diphosphate + L-seryl-[peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.72", "l": "\"L-serine--[L-seryl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10135", "l": "ATP + benzoate + CoA <=> AMP + benzoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172172", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25440", "l": "(2E,6E)-farnesyl diphosphate = delta-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40524", "l": "a quinone + succinate => a quinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59986", "l": "a carboxylate + L-glutamine => an N(2)-acyl-L-glutamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607002", "l": "Activated protein C cleaves factor VIIIa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41569", "l": "aclacinomycin T + dTDP-2-deoxy-beta-L-fucose => aclacinomycin S + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110468", "l": "Activation of DAkt1 by DPDK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65055", "l": "4-(trifluoromethyl)benzyl alcohol + NAD(+) <=> 4-(trifluoromethyl)benzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12614", "l": "2 glutathione + L-cystine => glutathione disulfide + 2 L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186773", "l": "PDGF dimer binds two receptors simultaneously (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69068", "l": "RFC dissociates after sliding clamp formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65045", "l": "4-cyanobenzyl alcohol + NAD(+) => 4-cyanobenzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31118", "l": "ATP + biotin + H(+) <=> biotinyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804402", "l": "TP53 binds POU4F1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44246", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66432", "l": "H(+)(out) + L-galactose(out) = H(+)(in) + L-galactose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008113", "l": "peptide-methionine (S)-S-oxide reductase activity", "d": ["Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32660", "l": "(6E)-8-hydroxygeraniol + 2 NADP(+) => (6E)-8-oxogeranial + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371467", "l": "SIRT1 deacetylates HSF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624948", "l": "KIF17 enters the cilium (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372359", "l": "pyruvate + H+ [cytosol] => pyruvate + H+ [mitochondrial matrix] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672083", "l": "KTN1 binds Kinesin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53762", "l": "allocholoyl-CoA + deoxycholate => allocholate + deoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11175", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine <=> (6S)-5,6,7,8-tetrahydrofolate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41645", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA => 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73843", "l": "a 27-hydroxysterol + UDP-alpha-D-glucose = a sterol 27-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043838", "l": "phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity", "d": ["Catalysis of the reaction: Kdo2-lipid A + phosphatidylethanolamine = phosphoethanolamine-Kdo2-lipid A + diacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75022", "l": "1,2,3-tri-(10Z)-heptadecenoylglycerol + 9-hydroxy-octadecanoate <=> 9-(10Z-heptadecenoyloxy)-octadecanoate + di-(10Z)-heptadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15546", "l": "(3S)-citramalate => acetate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55981", "l": "a 1,2-saturated acyl-CoA + an acyl-CoA + H2O => an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53151", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54161", "l": "2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2 => [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14241", "l": "3-amino-4-hydroxybenzaldehyde + acetyl-CoA = 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18894", "l": "a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose => a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15440", "l": "a long-chain fatty aldehyde + CoA + NADP(+) <=> a long-chain fatty acyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140842", "l": "RNA polymerase II C-terminal domain S5 O-GlcNAc transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine (position 5)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59881", "l": "4-hydroxyphenylacetate + FMNH2 + O2 => 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067640", "l": "IL6 binds IL6R-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32954", "l": "sucrose <=> trehalulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57750", "l": "C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71818", "l": "3,3',5'-triiodo-L-thyronine(out) <=> 3,3',5'-triiodo-L-thyronine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20457", "l": "D-arabinose + NAD(+) = D-arabinono-1,4-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75172", "l": "Formation of RAD50:MRE11 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71443", "l": "3-O-methyl-L-dopa(out) + L-phenylalanine(in) = 3-O-methyl-L-dopa(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68631", "l": "phycoerythrobilin-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73837", "l": "2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67769", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051742", "l": "2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-methyl-6-solanyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-solanyl-1,4-benzoquinone + S-adenosyl-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0008135", "l": "translation factor activity, RNA binding", "d": ["Functions during translation by binding to RNA during polypeptide synthesis at the ribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15766", "l": "adenosylcob(III)inamide + GTP => adenosylcob(III)inamide phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852013", "l": "BTNL8 binds resting T cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709852", "l": "MAVS:TOMM70 recruits HSP90:TBK1:IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047409", "l": "alkenylglycerophosphoethanolamine hydrolase activity", "d": ["Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine = sn-glycero-3-phosphoethanolamine + an aldehyde."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004910", "l": "interleukin-1, type II, blocking receptor activity", "d": ["Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805620", "l": "KAT6A and PML bind TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26064", "l": "ATP + hygromycin B = 4-O-phosphohygromycin B + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.163", "l": "\"hygromycin B 4-O-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14399", "l": "(4Z)-2-oxohept-4-enedioate + CO2 => (3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.240853996207278", "identifiers": [{"i": "GO:0004896", "l": "cytokine receptor activity", "d": ["Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203700", "l": "eNOS translocation from Golgi to Caveolae (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.31", "l": "\"ananain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626914", "l": "α2-agonists bind ADRA2A,B,C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16030", "l": "3-guanidinopropanoate + H2O => beta-alanine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58239", "l": "L-tyrosyl-[protein] + NAD(+) <=> H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46914", "l": "H(+) + juvenile hormone III carboxylate + methanol => H2O + juvenile hormone III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016532", "l": "superoxide dismutase copper chaperone activity", "d": ["A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57014", "l": "a menaquinol + sulfate => a menaquinone + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685953", "l": "SIRT6 deacetylates RBBP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15414", "l": "(2R,3R)-tartrate => H2O + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706293", "l": "Active FLT3 binds to CBL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37344", "l": "adenosine 2'-phosphate + H2O => adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032003", "l": "interleukin-28 receptor binding", "d": ["Binding to an interleukin-28 receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102262", "l": "tRNA-dihydrouridine16 synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil16 in tRNA + NAD(P) = H+ + a uracil16 in tRNA + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730892", "l": "Recruitment of VAV to p-SLP-76 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19508", "l": "indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose <=> (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213207", "l": "Formation of collagen networks (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12988", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36528", "l": "(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA => (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102318", "l": "2-deoxystreptamine glucosyltransferase activity", "d": ["Catalysis of the reaction: 2-deoxystreptamine + UDP-alpha-D-glucose <=> 2'-deamino-2'-hydroxyparomamine + UDP(3-) + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71310", "l": "chloride(out) + L-valine(out) + 2 Na(+)(out) <=> chloride(in) + L-valine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70259", "l": "AMP(out) + phosphate(in) = AMP(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69852", "l": "a 5,6-dihydrouridine in mRNA + NAD(+) => a uridine in mRNA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160874", "l": "HYAL1 hydrolyses (HA)50 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71448", "l": "D-alanine(in) + Na(+)(in) => D-alanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683648", "l": "Spike trimer glycoside chains are extended (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51400", "l": "octadecanoyl-CoA + serotonin = CoA + H(+) + N-octadecanoyl-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72918", "l": "D-fructopyranose(out) + Na(+)(out) <=> D-fructopyranose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13036", "l": "aldehydo-D-galactose 6-phosphate <=> keto-D-tagatose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29158", "l": "2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) <=> 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30652", "l": "2 H2O + O2 + urate => allantoin + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12620", "l": "ATP + N-acetyl-alpha-D-galactosamine <=> ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31849", "l": "shionone => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24116", "l": "(2E)-geranyl diphosphate + H2O = (S)-linalool + diphosphate", "d": []}, {"i": "EC:4.2.3.25", "l": "\"S-linalool synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798615", "l": "TP53 binds the TP53AIP1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102660", "l": "caffeoyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity", "d": ["Catalysis of the reaction: caffeoylshikimate + coenzyme A <=> caffeoyl-CoA + shikimate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0005021", "l": "vascular endothelial growth factor receptor activity", "d": ["Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45689", "l": "N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) => N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60049", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809238", "l": "MTMR7 binds MTMR9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853793", "l": "p-5Y-RET complexes bind GRB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75666", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate <=> 10,11-epoxy-12-hydroxy-(14Z)-eicosenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106319", "l": "(R)-limonene 1,2-monooxygenase NADH activity", "d": ["Catalysis of the reaction: (4R)-limonene + NADH + H+ + O2 = NAD+ + H2O + (4R)-limonene-1,2-epoxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653936", "l": "Formation of Ragulator complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211948", "l": "CYP3A4 can N-demethylate loperamide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19252", "l": "glyoxylate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215152", "l": "TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701064", "l": "TRPV1 binds TRPV1 agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17764", "l": "an aromatic primary alcohol + NADP(+) <=> an aromatic aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71972", "l": "3-hydroxyglutarate(out) + 3 Na(+)(out) => 3-hydroxyglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17824", "l": "hydrogen cyanide + L-cysteine <=> 3-cyano-L-alanine + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805546", "l": "Keratin type I binds keratin type II (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42503", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) <=> 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60196", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419166", "l": "GEFs activate RhoA,B,C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098505", "l": "G-rich strand telomeric DNA binding", "d": ["Binding to G-rich, single-stranded, telomere-associated DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44927", "l": "2-oxoadipate + acetyl-CoA + H2O <=> (R)-dihomocitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58496", "l": "choline + H(+) + NADH + O2 = glycolaldehyde + H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11159", "l": "H2O + L-valine + NADP(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.129", "l": "\"long-chain acyl-CoA omega-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013159", "l": "CDC42 GEFs activate CDC42 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52152", "l": "(Z)-2-(indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose = (Z)-indolylmethyl desulfoglucosinolate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21420", "l": "NADP(+) + prostaglandin I2 = 15-dehydro-prostaglandin I2 + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.231", "l": "\"15-hydroxyprostaglandin-I dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14290", "l": "a dicarboxylate + ATP + CoA => AMP + diphosphate + omega-dicarboxyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32296", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH => 2 diphosphate + NADP(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67623", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674022", "l": "BRAP autoubiquitinates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34033", "l": "acetate + paromamine => 2'-N-acetylparomamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22477", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) => 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39515", "l": "(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH = (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10234", "l": "5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate => 5,6-dihydrouridine 5'-monophosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612516", "l": "EGR1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56330", "l": "5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+) => 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811454", "l": "MAPKs phosphorylate PP2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102366", "l": "7-beta-hydroxytaxusin 2-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: 7-beta-hydroxytaxusin + NADPH + O2 + H+ = 2alpha, 7-beta-dihydroxytaxusin + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49847", "l": "(-)-dehydrodiconiferyl acid + a quinone <=> (-)-dehydrodiconiferyl acid ketone + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25733", "l": "(E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tetrahomomethionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862700", "l": "CMKLR1 binds Resolvin E1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69494", "l": "H2O2 + octanal => O2 + octan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769397", "l": "SOST binds LRP5/6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22528", "l": "a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose = a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.159", "l": "\"flavonol-3-O-glucoside L-rhamnosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66263", "l": "CoA + IC-asc-C7-AMP <=> AMP + H(+) + IC-asc-C7-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63703", "l": "mycophenolate + UDP-alpha-D-glucuronate <=> mycophenolic acid O-acyl-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33023", "l": "6-phospho-D-gluconate + NAD(+) = CO2 + D-ribulose 5-phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64650", "l": "(E)-feruloyl-CoA + H(+) + NADPH => (E)-coniferaldehyde + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21222", "l": "4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+) => L-dopa + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73528", "l": "TDP(out) + UTP(in) => TDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848873", "l": "PTK6 phosphorylates ARAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45505", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134914", "l": "Beta-catenin migrates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.43", "l": "\"classical-complement-pathway C3/C5 convertase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043882", "l": "malate:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + Na+(out) = malate(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20944", "l": "S-adenosyl-L-methionine + theobromine = caffeine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55598", "l": "globoside NORint + H(+) + UDP => globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9646468", "l": "mTORC1 binds RHEB:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015153", "l": "rhamnose transmembrane transporter activity", "d": ["Enables the transfer of rhamnose from one side of a membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids."]}, {"i": "RHEA:34995", "l": "L-rhamnose(in) = L-rhamnose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694527", "l": "Loss of SAR1B GTPase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50531", "l": "acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44718", "l": "AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+) => A + all-trans-4,4'-diapolycopen-4-al + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49015", "l": "aurachin C + H(+) + NADH + O2 <=> aurachin C epoxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690785", "l": "BAP1 binds Ub-HCFC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033529", "l": "TYSND1 cleaves ACAA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201630", "l": "Caspase-mediated cleavage of Acinus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036052", "l": "Defective NAGLU does not hydrolyse heparan chain(2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68389", "l": "2 5,6-dihydroxyindole-2-carboxylate + O2 => 2 H2O + 2 indole-5,6-quinone-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031824", "l": "type 1E serotonin receptor binding", "d": ["Binding to a type 1E serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62737", "l": "1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0019763", "l": "immunoglobulin receptor activity", "d": ["Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65453", "l": "ethanol + hexanoyl-CoA => CoA + ethyl hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41820", "l": "butanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17728", "l": "(2S,3S)-2-methylcitrate <=> 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28839", "l": "H(+)(out) + Zn(2+)(in) = H(+)(in) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047845", "l": "deoxylimonate A-ring-lactonase activity", "d": ["Catalysis of the reaction: deoxylimonoate + H2O = deoxylimononate D-ring-lactone + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33376", "l": "a 1-acylglycerone 3-phosphate + H(+) + NADPH => a 1-acyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.283", "l": "\"2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848436", "l": "PTK6 phosphorylates CDKN1B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847977", "l": "FRK phosphorylates PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852324", "l": "GTSE1 binds PLK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32140", "l": "ATP + CoA + malonate => AMP + diphosphate + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48885", "l": "NADP(+) + protochlorophyllide a => 3,8-divinyl protochlorophyllide a + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682992", "l": "KDM4A,B bind H4K20Me2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74187", "l": "S-adenosyl-L-methionine + taxifolin = H(+) + S-adenosyl-L-homocysteine + taxifolin 3'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17978", "l": "a long-chain primary fatty alcohol + H2O + 2 NAD(+) => a long-chain fatty acid + 3 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651789", "l": "LIG1 bound to POLB ligates SSB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55244", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4beta-methylzymosterol-4alpha-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11345", "l": "an N-acylneuraminate + CTP => a CMP-N-acyl-beta-neuraminate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35259", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63814", "l": "AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine) => ATP + N(8)-citryl-spermidine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15328", "l": "an acyl-CoA + sn-glycerol 3-phosphate <=> a 1-acyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811454", "l": "MAPKs phosphorylate PP2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781941", "l": "WNTs are secreted in exosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5658430", "l": "NF1 is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67831", "l": "a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine <=> a lipid A disaccharide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47865", "l": "1,2,3-trioctanoylglycerol + H2O => dioctanoylglycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39168", "l": "H(+) + malonyl-CoA + tetradecanoyl-CoA => 3-oxohexadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31618", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine <=> dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54425", "l": "L-aspartyl-[protein] + NAD(+) => 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211712", "l": "Proteolytic PAK-2p34 fragment translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56359", "l": "3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 <=> 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62189", "l": "9alpha-copalyl diphosphate => diphosphate + syn-isopimara-7,15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43968", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982637", "l": "Opsins binds G alpha-t (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664261", "l": "Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46619", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60924", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + L-lysyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53415", "l": "(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449818", "l": "IL13 binds IL13RA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54338", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15329", "l": "(S)-ureidoglycolate + NAD(+) = H(+) + N-carbamoyl-2-oxoglycine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67543", "l": "(9Z)-hexadecenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57087", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378952", "l": "Thyrotropin is a heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418845", "l": "Activation of caspase-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68960", "l": "DNA polymerase epsilon binds at the origin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32455", "l": "(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38477", "l": "H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine => L-histidine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75854", "l": "all-trans-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23116", "l": "4-hydroxybenzoate + ATP + CoA = 4-hydroxybenzoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.27", "l": "\"4-hydroxybenzoate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944261", "l": "Association of procollagen type XIII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903876", "l": "11-deoxycortisol binding", "d": ["Binding to 11-deoxycortisol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38340", "l": "(20S)-ginsenoside Rb1 + H2O => (20S)-ginsenoside Rd + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24965", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10267", "l": "alpha-D-glucose <=> beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782416", "l": "TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928656", "l": "gamma-secretase cleaves EPHB2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814096", "l": "ARL1:GTP binds SCOC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23469", "l": "2-aminobenzenesulfonate + 2 H(+) + NADH + O2 => 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174124", "l": "Dephosphorylation of phospho-Cdh1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58000", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose = (20S)-ginsenoside Rg3 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48429", "l": "1-(9Z,12Z-octadecadienoyl)-glycerol + H2O => (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71934", "l": "fumarate(out) + 3 Na(+)(out) <=> fumarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68610", "l": "Formation of ORC(2-5) complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784861", "l": "HSPG binds LPL dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53414", "l": "(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62262", "l": "2 hydrogencarbonate(in) + Mn(2+)(in) => 2 hydrogencarbonate(out) + Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676912", "l": "Methionine is oxidised to methionine sulfoxide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046029", "l": "mannitol dehydrogenase activity", "d": ["Catalysis of the reaction: D-mannitol + NAD+ = D-mannose + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35915", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032406", "l": "MutLbeta complex binding", "d": ["Binding to a MutLbeta mismatch repair complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48673", "l": "20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939870", "l": "UCMA gene expression is stimulated by RUNX2 and SP7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865454", "l": "CBFB binds RUNX3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0061631", "l": "ubiquitin conjugating enzyme activity", "d": ["Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue."]}, {"i": "EC:2.3.2.23", "l": "\"E2 ubiquitin-conjugating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727349", "l": "XDH dehydrogenates xanthine to form urate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174551", "l": "Formation of alternative pathway C5 convertase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42602", "l": "A + H2O + prostaglandin H2 => AH2 + prostaglandin G2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52348", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016432", "l": "tRNA-uridine aminocarboxypropyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13855", "l": "4-methylene-L-glutamine + AMP + diphosphate + H(+) => 4-methylene-L-glutamate + ATP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15894", "l": "Co-sirohydrochlorin + 2 H(+) => Co(2+) + sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58641", "l": "a 5'-end (5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine => a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944215", "l": "Association of procollagen type XX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13960", "l": "4 H2O + O2 + 4 sulfur <=> 6 H(+) + 2 hydrogen sulfide + 2 sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63918", "l": "5-fluorouridine 5'-phosphate + ADP + H(+) => 5-fluorouridine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176452", "l": "Degradation of ubiquitinated SMAD2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67919", "l": "adenosine 5'-phosphoramidate + H2O <=> AMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.70", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35160", "l": "(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54104", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63211", "l": "5-amino-6-(D-ribitylamino)uracil + glyoxal <=> 5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374896", "l": "Uptake of Noradrenaline (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65268", "l": "3-hydroxypentacecilide A + H(+) + NADPH + O2 = chrodrimanin F + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27473", "l": "ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.167", "l": "\"D-glycero-beta-D-manno-heptose-7-phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43092", "l": "S-adenosyl-L-methionine + uridine(2479) in 23S rRNA = 2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.208", "l": "\"23S rRNA (uridine(2479)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69529", "l": "chorismate + H2O + 2 L-glutamine => 4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70835", "l": "L-arginine(in) + L-glutamine(out) + Na(+)(out) = L-arginine(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62377", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H2O => (S)-lactate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007539", "l": "CHEK1 phosphorylates E2F6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40351", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70494", "l": "GDP-beta-L-fucose + L-threonyl-[protein] <=> 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60304", "l": "N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168894", "l": "Accumulation of M1 at the inner leaflet of the lipid bilayer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62803", "l": "2 7-demethylsiderin + NADPH + O2 <=> 2 H2O + NADP(+) + orlandin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64108", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41027", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21109", "l": "(S)-3-methyl-2-oxopentanoate + H(+) => 2-methylbutanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21687", "l": "(R)-beta-alanopine + H2O + NAD(+) <=> beta-alanine + H(+) + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140681", "l": "histone H3K36me2/H3K36me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549304", "l": "OCT3 mediates renal clearance of organic cations (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53323", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose <=> alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629679", "l": "PDE3A inhibitors bind PDE3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034579", "l": "(1-methylpentyl)succinate synthase activity", "d": ["Catalysis of the reaction: fumarate + n-hexane = (1-methylpentyl)succinate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052600", "l": "propane-1,3-diamine oxidase activity", "d": ["Catalysis of the reaction: propane-1,3-diamine + H2O + O2 = 3-aminopropanal + NH3 + hydrogen peroxide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39868", "l": "3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol => 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19548", "l": "H2O + sn-glycerol 3-phosphocholine <=> glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46115", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29217", "l": "menaquinone-8 + succinate => fumarate + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36329", "l": "diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate => ADP + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426209", "l": "DAG activation of TRPC channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25323", "l": "H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine => N-methylethanolamine phosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43666", "l": "2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate => ATP + hydrogencarbonate + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047728", "l": "carnitine 3-dehydrogenase activity", "d": ["Catalysis of the reaction: carnitine + NAD+ = 3-dehydrocarnitine + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3238694", "l": "PORCN palmitoleoylates N-glycosyl WNTs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36766", "l": "alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177920", "l": "Binding of GRB2 to GAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60096", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 3-dehydro-4alpha-methylzymosterol + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22291", "l": "an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O <=> an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12486", "l": "a ribonucleoside + phosphate => a ribonucleoside 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65201", "l": "S-(acetaldehyde)-L-cysteine => (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17578", "l": "ADP-D-glycero-beta-D-manno-heptose => ADP-L-glycero-beta-D-manno-heptose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23418", "l": "(2R)-3-sulfolactate + phosphate => (2R)-O-phospho-3-sulfolactate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730836", "l": "Interaction of BCL10:MALT1 with CARMA1 to form CBM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61231", "l": "H2O + L-histidine + O2 <=> 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58431", "l": "(E,E)-2,4-hexadien-1-ol + NADP(+) <=> (E,E)-2,4-hexadienal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52017", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36835", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71303", "l": "RPE dimers isomerise RU5P to XY5P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29087", "l": "(S)-malate + menaquinone-8 = menaquinol-8 + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56611", "l": "5,10-methylenetetrahydrosulfopterin + glycine + H2O <=> L-serine + tetrahydrosulfopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130151", "l": "Dimerization of DAP12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58823", "l": "H(+) + malonate + Na(+)(in) <=> acetate + CO2 + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10866", "l": "2-(acetamidomethylene)succinate + NADP(+) => 3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66536", "l": "A + cholest-4,6-dien-3-one + H2O = 25-hydroxycholest-4,6-dien-3-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050098", "l": "methylguanidinase activity", "d": ["Catalysis of the reaction: H2O + methylguanidine = methylammonium + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156699", "l": "Inactivation of Wee1 kinase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61100", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40667", "l": "2-aminoprop-2-enoate = 2-iminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036046", "l": "Defective IDS does not hydrolyse Heparan sulfate chain(5) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42054", "l": "9-cis-retinal + H(+) + NADH => 9-cis-retinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35917", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25728", "l": "N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015093", "l": "ferrous iron transmembrane transporter activity", "d": ["Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047458", "l": "beta-pyrazolylalanine synthase activity", "d": ["Catalysis of the reaction: O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65569", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71293", "l": "(R)-carnitine(in) + chloride(in) + 2 Na(+)(in) => (R)-carnitine(out) + chloride(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30458", "l": "(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O <=> (-)-geosmin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47190", "l": "hydrogen sulfide + methyl-Co(III)-[methylated-thiol-specific corrinoid protein] => Co(I)-[methylated-thiol-specific corrinoid protein] + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40489", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17246", "l": "3-hydroxyanthranilate + O2 => 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870469", "l": "RGGT geranylgeranylates RAB proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48236", "l": "2 2-acetylphloroglucinol = 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)", "d": []}, {"i": "EC:2.3.1.272", "l": "\"2-acetylphloroglucinol acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68714", "l": "(1S,2S,4R)-beta-elemene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0045309", "l": "protein phosphorylated amino acid binding", "d": ["Binding to a phosphorylated amino acid residue within a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9753634", "l": "GGT dimers hydrolyse APAP-SG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070612", "l": "histone H2AR3 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H2A)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to the arginine residue at position 3 of histone H2A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61373", "l": "4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O => 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.22.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31450", "l": "6-amino-2-oxohexanoate + H2O2 <=> 5-aminopentanoate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783880", "l": "PIPOX oxidises PPCA to P6C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21859", "l": "cyclohexa-1,5-diene-1-carbonyl-CoA + H2O <=> 6-hydroxycyclohex-1-ene-1-carbonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12598", "l": "acetyl-CoA + phosphinothricin => CoA + H(+) + N-acetylphosphinothricin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27883", "l": "2',3'-cyclophospho-CMP + H2O => 3'-CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19087", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689861", "l": "Recruitment of XPA and release of CAK  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388814", "l": "Grb2 binds CD28 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14760", "l": "2 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone <=> 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11012", "l": "H2O + L-tryptophanamide = L-tryptophan + NH4(+)", "d": []}, {"i": "EC:3.5.1.57", "l": "\"tryptophanamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047611", "l": "acetylspermidine deacetylase activity", "d": ["Catalysis of the reaction: N(8)-acetylspermidine + H2O = acetate + spermidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13695", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+) => (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036121", "l": "double-stranded DNA helicase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of double-stranded DNA; drives the unwinding of a DNA helix."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0140319", "l": "receptor decoy activity", "d": ["Binding and sequestering a specific receptor ligand to prevent it from binding to its regular receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62898", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+) => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43488", "l": "7(1)-hydroxychlorophyll a + NAD(+) = chlorophyll b + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18035", "l": "4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => benzoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56606", "l": "6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71927", "l": "2 Na(+)(out) + tauroursodeoxycholate(out) = 2 Na(+)(in) + tauroursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757574", "l": "ALB binds PREDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434989", "l": "SEMA7A binds to PLXNC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29794", "l": "ATP + glutathione(out) + H2O <=> ADP + glutathione(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71139", "l": "acetyl-CoA + 3 AH2 + 18 H(+) + 10 malonyl-CoA + 8 NADPH = 3 A + 10 CO2 + 11 CoA + cordypyrone A + 8 H2O + 8 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69143", "l": "N-(4-aminobutyl)-3-aminopropanal <=> acrolein + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047663", "l": "aminoglycoside 6'-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + kanamycin B = N(6')-acetylkanamycin B + CoA + H+. This is acetylation of the 6'-amino group of the 6-deoxy-6-aminoglucose ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665727", "l": "FMNL2 binds CDC42:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667563", "l": "AVPR2 bind desmopressin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30875", "l": "2-oxoglutarate + D-lysine = 6-amino-2-oxohexanoate + D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47012", "l": "[DsrC protein]-disulfide + H(+) + hydrogen sulfide = [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362793", "l": "Hh-Np is cleaved by ADAM17 to promote ligand shedding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25095", "l": "ATP + dCMP => ADP + dCDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604752", "l": "Initial activation of proMMP13 by MMP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034902", "l": "endosulfan sulfate hydrolase activity", "d": ["Catalysis of the reaction: endosulfan sulfate + H2O = endosulfan diol + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50975", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 <=> (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18031", "l": "2 ADP + carbamoyl phosphate + 2 H(+) + phosphate => 2 ATP + hydrogencarbonate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010815", "l": "SLITs bind keratan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8939204", "l": "ESTG binds ESR1:chaperone complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59128", "l": "(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP = 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate", "d": []}, {"i": "EC:6.3.2.55", "l": "\"2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77081", "l": "Formation of the CE:GMP intermediate complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74712", "l": "Dissociation of IRS-P from insulin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707690", "l": "BACH1 binds MAFK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47982", "l": "dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose => dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018445", "l": "prothoracicotrophic hormone activity", "d": ["The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58045", "l": "a long-chain fatty acyl-CoA + alpha,alpha-trehalose => 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27704", "l": "keto-D-tagaturonate => aldehydo-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679028", "l": "JAK3 binds JAK3 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052581", "l": "(-)-isopiperitenone reductase activity", "d": ["Catalysis of the reaction: (6R)-isoperitenone + H+ + NADPH = (2R,5R)-isopulegone + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53712", "l": "2 Fe(III)-heme b = beta-hematin", "d": []}, {"i": "EC:4.99.1.8", "l": "\"heme ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35761", "l": "aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase] => 8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54568", "l": "a uridine in rRNA = a pseudouridine in rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40307", "l": "A + decanedioyl-CoA = (2E)-decenedioyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27717", "l": "GMP + H2O <=> guanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161619", "l": "PGI2 is hydrolysed to 6k-PGF1a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801666", "l": "PLK2 phosphorylates CENPJ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252072", "l": "AZGP1 binds PIP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54325", "l": "a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin] => a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43459", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA <=> (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901641", "l": "ITP binding", "d": ["Binding to ITP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49611", "l": "2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) <=> 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70855", "l": "L-glutamine(out) + L-serine(in) + Na(+)(out) = L-glutamine(in) + L-serine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047087", "l": "protopine 6-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + protopine = 6-hydroxyprotopine + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44668", "l": "4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol = 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": []}, {"i": "EC:2.7.8.47", "l": "\"teichoic acid ribitol-phosphate polymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047517", "l": "1,4-beta-D-xylan synthase activity", "d": ["Catalysis of the reaction: UDP-D-xylose + [(1->4)-beta-D-xylan](n) = UDP + [(1->4)-beta-D-xylan](n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25447", "l": "(2E,6E)-farnesyl diphosphate <=> (1E,4E)-germacrene B + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26204", "l": "ammeline + H(+) + H2O <=> ammelide + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018756", "l": "RHOH binds GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54398", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.10.-.-", "l": "\"Transferring molybdenum- or tungsten-containing groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000215", "l": "tRNA 2'-phosphotransferase activity", "d": ["Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57495", "l": "H2O + oxaloacetate + propanoyl-CoA <=> 2-methylcitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426156", "l": "SREBP1A,2 binds the PMVK promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64582", "l": "diphosphate + nerylneryl diphosphate => (2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.712091546727706", "identifiers": [{"i": "GO:1990837", "l": "sequence-specific double-stranded DNA binding", "d": ["Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44184", "l": "D-sedoheptulose 7-phosphate = 2-epi-5-epi-valiolone + phosphate", "d": []}, {"i": "EC:4.2.3.152", "l": "\"2-epi-5-epi-valiolone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168306", "l": "Concerted hemagglutinin pore formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266303", "l": "Spherical HDL binds C and E apolipoproteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59553", "l": "N,N',N'',N'''-tetraacetylchitotetraose + O2 => H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917693", "l": "ESCRT Disassembly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050392", "l": "vicianin beta-glucosidase activity", "d": ["Catalysis of the reaction: (R)-vicianin + H2O = mandelonitrile + vicianose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46755", "l": "7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382096", "l": "Formation of NR-NCOR Corepressor Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51219", "l": "3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one <=> adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27808", "l": "acetate + acetoacetyl-CoA => acetoacetate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58362", "l": "(5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65241", "l": "(11Z)-octadecenoyl-CoA + H2O => (11Z)-octadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69547", "l": "ATP + streptidine <=> 6-O-adenylylstreptidine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433506", "l": "Phosphorylation of APS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863973", "l": "Fusion of ERC and phagosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21098", "l": "3-dehydroshikimate + H2O => 3-dehydroquinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53900", "l": "ATP + L-threonyl-[myosin light chain] = ADP + H(+) + O-phospho-L-threonyl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16995", "l": "6 Fe(II)-[cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] => 6 Fe(III)-[cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199404", "l": "CD40L binds CD40 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9702818", "l": "CALCR binds erenumab (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64751", "l": "H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine <=> 2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451310", "l": "Activation of Edited Kainate receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30552", "l": "acetyl-CoA + beta-D-glucose => 6-O-acetyl-beta-D-glucose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0099528", "l": "G protein-coupled neurotransmitter receptor activity", "d": ["Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51098", "l": "19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17763", "l": "an aromatic aldehyde + H(+) + NADPH => an aromatic primary alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21471", "l": "dTDP-alpha-D-mycaminose + tylactone <=> 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31057", "l": "estrone + H(+) + sulfate => estrone 3-sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209815", "l": "Tyrosine is monoiodinated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265867", "l": "Formation of RPA-heterotrimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29386", "l": "dIMP + H2O <=> 2'-deoxyinosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36182", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-choline <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69093", "l": "H2O + NAD(+) + pentanal => 2 H(+) + NADH + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60814", "l": "CO2 + gibberellin A12 + H(+) + succinate => 2-oxoglutarate + gibberellin A12 aldehyde + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5444516", "l": "Formation of MSH2:MSH6 Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0043121", "l": "neurotrophin binding", "d": ["Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.86", "l": "\"limulus clotting enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042888", "l": "molybdenum ion transmembrane transporter activity", "d": ["Enables the transfer of molybdenum (Mo) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047015", "l": "3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69057", "l": "H(+) + N(omega)-methyl-L-arginine + NADH + O2 => H2O + N(delta)-hydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213017", "l": "Auto-ubiquitination of TRAF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15542", "l": "DIMBOA + UDP-alpha-D-glucose => DIMBOA beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75933", "l": "taurine + urea => H2O + taurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2514831", "l": "Fibrillin-1 degradation by MMP14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614605", "l": "Persulfide sulfur is dioxygenated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0070739", "l": "protein-glutamic acid ligase activity", "d": ["Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37796", "l": "2 H(+) + 2 NADPH + O2 => 2 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63521", "l": "2-isopropylphenol + H(+) + NADH + O2 => 3-isopropylcatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66825", "l": "2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72673", "l": "1,6-dihydroxyphenazine + CO2 + H2O + NAD(+) => 6-hydroxyphenazine-1-carboxylate + 2 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0031835", "l": "substance P receptor binding", "d": ["Binding to a substance P receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047891", "l": "flavone 7-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + 5,7,3',4'-tetrahydroxyflavone = UDP + 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48680", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.330", "l": "\"very-long-chain 3-oxoacyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48405", "l": "apo-[aryl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20830", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2 => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956684", "l": "ITCH polyubiquitinates TP73 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993781", "l": "Conjugation of SUMO3 to UBA2:SAE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40306", "l": "A + dodecanedioyl-CoA <=> (2E)-dodecenedioyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71849", "l": "LDH tetramer reduces PYR to LACT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034805", "l": "benzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene-trans-11,12-dihydrodiol = 11,12-dihydroxybenzo(a)pyrene + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23730", "l": "A + H2O + prostaglandin H2 => (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26036", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034568", "l": "isoproturon dimethylaminedehydrogenase activity", "d": ["Catalysis of the reaction: isoproturon + H2O = formaldehyde + monodemethylisoproturon + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336443", "l": "LIN7, CASK and APBA1 bind (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72582", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O <=> (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213207", "l": "Formation of collagen networks (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677050", "l": "Formation of the GCN5-ATAC complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018768", "l": "RHOU auto-activates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16871", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002440", "l": "Removal of fibrillar collagen C-propeptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043250", "l": "sodium-dependent organic anion transmembrane transporter activity", "d": ["Enables the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75862", "l": "Fall Back to Closed Pre-initiation Complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20657", "l": "4-chlorophenylacetonitrile + 2 H2O = 4-chlorophenylacetate + NH4(+)", "d": []}, {"i": "EC:3.5.5.5", "l": "\"arylacetonitrilase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033850", "l": "Z-farnesyl diphosphate synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-cis,6-trans-farnesyl diphosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72697", "l": "Start codon recognition (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442715", "l": "Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46158", "l": "9,9',15-tri-cis-zeta-carotene + a plastoquinol => 15,9'-di-cis-phytofluene + a plastoquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72661", "l": "8-hydroxyquinoline N-oxide + H2O + NADP(+) => NADPH + O2 + quinolin-8-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939204", "l": "ESTG binds ESR1:chaperone complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9663511", "l": "BIL binds GSTA1, FABP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33242", "l": "L-threonine + NAD(+) <=> aminoacetone + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69557", "l": "D-glucose(out) + H(+)(out) => D-glucose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983696", "l": "The Immunoglobulin of the BCR binds antigen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14623", "l": "lanosterol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11980", "l": "2 gamma-L-glutamyl-L-cysteine + NADP(+) = bis-gamma-glutamylcystine + H(+) + NADPH", "d": []}, {"i": "EC:1.8.1.13", "l": "\"bis-gamma-glutamylcystine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61431", "l": "cis-trans-nepetalactol + NAD(+) <=> cis-trans-nepetalactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944225", "l": "Association of procollagen type XVII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44707", "l": "a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211387", "l": "Anthrax lef cleaves target cell MAP2K7 (MEK7) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9726509", "l": "NR3C2 binds fludrocortisone (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35321", "l": "3-oxoeicosanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944599", "l": "miR-93 microRNA binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27438", "l": "2 glutathione amide + H2O2 => glutathione amide disulfide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32109", "l": "H(+) + pterostilbene + S-adenosyl-L-homocysteine => 3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.054311793581761", "identifiers": [{"i": "GO:0140938", "l": "histone H3 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a histone H3 = S-adenosyl-L-homocysteine + a methylated histone H3. Histone methylation generally occurs on either an arginine or a lysine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007860", "l": "RUNX2 binds TWIST1,(TWIST2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733323", "l": "Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20322", "l": "L-proline + NAD(+) => 1-pyrroline-2-carboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452353", "l": "Expression of EOMES in the primitive streak (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27974", "l": "6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)", "d": []}, {"i": "EC:4.3.99.3", "l": "\"7-carboxy-7-deazaguanine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38713", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865774", "l": "TTLLs polyglutamylate tubulin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28205", "l": "2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate <=> 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69899", "l": "2 Na(+)(out) + thymidine(out) = 2 Na(+)(in) + thymidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67713", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8934742", "l": "RUNX1 binds PRMT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51978", "l": "an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27442", "l": "NAD(+) + xylitol => D-xylose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68954", "l": "Mcm2-7 is phosphorylated by DDK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19746", "l": "3,3',5-triiodo-L-thyronine + A + H(+) + iodide => AH2 + L-thyroxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18343", "l": "D-xylonate + H(+) => D-xylono-1,4-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202713", "l": "CD84 homodimerises (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018795", "l": "2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity", "d": ["Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30293", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31487", "l": "soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose = H(+) + soyasaponin III + UDP", "d": []}, {"i": "EC:2.4.1.272", "l": "\"soyasapogenol B glucuronide galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47071", "l": "4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41933", "l": "H2O + hexadecanoyl-[ACP] => H(+) + hexadecanoate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14619", "l": "CoA-glutathione + H(+) + NADPH => CoA + glutathione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381612", "l": "GLP1R binds GLP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428752", "l": "Dissociation of the TP:Gq complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.16", "l": "\"versatile peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380316", "l": "Association of NuMA with microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.103", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031176", "l": "endo-1,4-beta-xylanase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20984", "l": "a sphingomyelin + H2O = an N-acylsphing-4-enine 1-phosphate + choline + H(+)", "d": []}, {"i": "EC:3.1.4.41", "l": "\"sphingomyelin phosphodiesterase D\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870469", "l": "RGGT geranylgeranylates RAB proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782419", "l": "TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029680", "l": "Caspase-7 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39901", "l": "7-deoxyloganin + H(+) + UDP => 7-deoxyloganetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19147", "l": "D-glucose + H(+) + sulfate => D-glucose 6-sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61362", "l": "ADP + H(+) + pheophorbide a(out) + phosphate => ATP + H2O + pheophorbide a(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46705", "l": "ATP + H(+) + salicylate => 2-hydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873917", "l": "Translocation of STAT1 dimer to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39835", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62981", "l": "(9Z)-hexadecenamide + H2O => (9Z)-hexadecenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798126", "l": "TP53 stimulates CASP6 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44006", "l": "a 3-methyl fatty acyl-CoA + AMP + diphosphate => 3-methyl fatty acid + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5660662", "l": "ASC binds Caspase-8 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419087", "l": "LIM kinase phosphorylation by ROCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15103", "l": "CO2 + L-lysine => H(+) + meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20045", "l": "3-oxopropanoate + H2O + NAD(+) = 2 H(+) + malonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679266", "l": "Beclin-1 complex translocates to the ER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950398", "l": "CANX dissociates from IL27:EBI3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909732", "l": "Phosphorylation of STAT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63301", "l": "N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043889", "l": "(S)-3-O-geranylgeranylglyceryl phosphate synthase activity", "d": ["Catalysis of the alkylation of the primary hydroxyl group in (S)-glyceryl phosphate by geranylgeranyl diphosphate to form (S)-3-O-geranylgeranylglyceryl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14665", "l": "guanine + H(+) + H2O = NH4(+) + xanthine", "d": []}, {"i": "EC:3.5.4.3", "l": "\"guanine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11119", "l": "acetyl-CoA + an alkane-alpha,omega-diamine <=> an N-acetylalkane-alpha,omega-diamine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23911", "l": "H(+) + 2 methylcob(III)alamin-[methionine synthase] + NADP(+) + 2 S-adenosyl-L-homocysteine <=> 2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57129", "l": "H2O + 2 oxidized [azurin] + tyramine => (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63754", "l": "carminate + 2 H(+) + UDP => kermesate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051786", "l": "all-trans-retinol 13,14-reductase activity", "d": ["Catalysis of the reaction: all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH(2). Note that this reaction has only been observed to occur in the opposite direction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29666", "l": "H(+)(in) + xanthine(in) <=> H(+)(out) + xanthine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20505", "l": "an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid", "d": []}, {"i": "EC:4.3.2.9", "l": "\"gamma-glutamylcyclotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29772", "l": "arsenate(in) + ATP + H2O => ADP + arsenate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4411373", "l": "NLK translocates to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989773", "l": "Expression of CPT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693575", "l": "DNA-PKcs autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082391", "l": "Trimerization of HSF1 in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36042", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31206", "l": "acetyl-CoA + hexanoyl-CoA <=> 3-oxooctanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11810", "l": "bergapten + S-adenosyl-L-homocysteine => bergaptol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400204", "l": "PPARA binds RXRA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25371", "l": "(2S)-2-amino-4-deoxychorismate + FMN = 3-(1-carboxyvinyloxy)anthranilate + FMNH2", "d": []}, {"i": "EC:1.3.8.16", "l": "\"2-amino-4-deoxychorismate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198599", "l": "AKT phosphorylates MDM2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163090", "l": "Elongation Of The Telomeric Chromosome End (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015394", "l": "uridine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uridine(out) + H+(out) = uridine(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76110", "l": "(11R)-methyl carlactonoate + 2-oxoglutarate + O2 <=> (11R)-hydroxymethyl carlactonoate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602892", "l": "Defective GCLC does not ligate L-Glu to L-Cys (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38107", "l": "2-dehydro-3-deoxy-L-galactonate = L-glyceraldehyde + pyruvate", "d": []}, {"i": "EC:4.1.2.54", "l": "\"L-threo-3-deoxy-hexylosonate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64888", "l": "ATP + holo-[ACP] + tetradecanoate = AMP + diphosphate + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36536", "l": "docosanoyl-CoA + sphinganine => CoA + H(+) + N-docosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20904", "l": "(S)-2-hydroxypropyl-coenzyme M = (S)-1,2-epoxypropane + coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050373", "l": "UDP-arabinose 4-epimerase activity", "d": ["Catalysis of the reaction: UDP-L-arabinose = UDP-alpha-D-xylose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50176", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004484", "l": "mRNA guanylyltransferase activity", "d": ["Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389762", "l": "Phosphorylation of PD-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17062", "l": "H(+) + NADPH + O2 + phenol => catechol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45992", "l": "(3R)-3-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0030235", "l": "nitric-oxide synthase regulator activity", "d": ["Binds to and modulates the activity of nitric oxide synthase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5681987", "l": "LC3 is cleaved by ATG4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59466", "l": "H(+) + NADPH + octadecanal => NADP(+) + octadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23948", "l": "4-hydroxybutanoate + NAD(+) = H(+) + NADH + succinate semialdehyde", "d": []}, {"i": "EC:1.1.1.61", "l": "\"4-hydroxybutyrate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015324", "l": "peptide-acetyl-CoA secondary active transmembrane transporter activity", "d": ["Enables the transfer of peptide-acetyl-CoA from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202437", "l": "Phosphorylation of CARMA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1370505", "l": "PRLR is phosphorylated at Ser-349 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003836", "l": "beta-galactoside (CMP) alpha-2,3-sialyltransferase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687107", "l": "MAPK4,6 translocate to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20968", "l": "L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": []}, {"i": "EC:4.2.1.25", "l": "\"L-arabinonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21728", "l": "GDP-alpha-D-mannose + H2O + 2 NAD(+) = GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH", "d": []}, {"i": "EC:1.1.1.132", "l": "\"GDP-mannose 6-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202709", "l": "JAM2 dimerises (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45478", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928631", "l": "GIT1 binds bPIX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4411373", "l": "NLK translocates to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102106", "l": "curcumin synthase activity", "d": ["Catalysis of the reaction: feruloylacetyl-CoA + feruloyl-CoA(4-) + H2O <=> curcumin + 2 coenzyme A(4-) + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61724", "l": "a D-glucoside + NAD(+) = a 3-dehydro-D-glucoside + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956639", "l": "RUNX1 binds YAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63355", "l": "2 H(+) + O2 + octadecanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] <=> (9Z)-octadecenoyl-CoA + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30451", "l": "(S)-2,3-epoxysqualene = isomultiflorenol", "d": []}, {"i": "EC:5.4.99.36", "l": "\"isomultiflorenol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13663", "l": "N-formyl-L-aspartate + NH4(+) => H2O + N-formimidoyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.111", "l": "\"2-oxoglutaramate amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727860", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to UBE2I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252001", "l": "ATP1B4 binds SNW1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-921155", "l": "p-STAT5 dissociates from the receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047900", "l": "formate kinase activity", "d": ["Catalysis of the reaction: ATP + formate = ADP + formyl phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59965", "l": "L-seryl-[protein] + octanoyl-CoA => CoA + O-octanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48987", "l": "(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + glyoxylate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48886", "l": "3,8-divinyl protochlorophyllide a + H(+) + NADPH => NADP(+) + protochlorophyllide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22600", "l": "H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687435", "l": "Enhanced autophagosome formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390663", "l": "ADRA2A,B,C bind ADR,NAd (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690785", "l": "BAP1 binds Ub-HCFC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69457", "l": "3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH => 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15543", "l": "DIMBOA beta-D-glucoside + H(+) + UDP => DIMBOA + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322427", "l": "Beta-catenin recruits CBP/p300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866857", "l": "CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391168", "l": "SIRP gamma binds CD47 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48457", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O => 2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51337", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33604", "l": "H(+) + N-hexacosanoylsphinganine + NADPH + O2 => H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972952", "l": "POU5F1 (OCT4), NANOG bind the GATA6 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429101", "l": "HMIT co-transports myo-inositol with a proton (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35054", "l": "N,N'-diacetylchitobiose(out) <=> N,N'-diacetylchitobiose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.958976004066542", "identifiers": [{"i": "GO:0019842", "l": "vitamin binding", "d": ["Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72167", "l": "2 Na(+)(out) + taurohyodeoxycholate(out) = 2 Na(+)(in) + taurohyodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139918", "l": "Phosphorylation of BIM by JNK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814555", "l": "Integrator complex processes the 3' end of snRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40477", "l": "butanoate + dibutanoylglycerol + H(+) => 1,2,3-tributanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40364", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28255", "l": "(3Z)-hex-3-en-1-ol + acetyl-CoA => (3Z)-hex-3-en-1-yl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33688", "l": "3'-N-debenzoyltaxol + benzoyl-CoA => CoA + H(+) + taxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69140", "l": "RPA binds to the Flap (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649108", "l": "HTR3A pentamer binds 5HT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34179", "l": "H2O + mycophenolic acid O-acyl-beta-D-glucuronide = D-glucuronate + H(+) + mycophenolate", "d": []}, {"i": "EC:3.1.1.93", "l": "\"mycophenolic acid acyl-glucuronide esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23904", "l": "an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]", "d": []}, {"i": "EC:2.3.2.2", "l": "\"gamma-glutamyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32548", "l": "(2E)-geranyl diphosphate => (1R,5R)-sabinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.4", "l": "\"aldehyde dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944104", "l": "PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50635", "l": "a 2-(omega-methylsulfanyl)alkylmalate <=> a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23584", "l": "7,8-dihydropteroate + ATP + L-glutamate = 7,8-dihydrofolate + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.12", "l": "\"dihydrofolate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37376", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70463", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + H2O + O2 = a 2'-deoxyadenosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322429", "l": "XIAP monoubiquinates TLE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29551", "l": "H2O + UDP-alpha-D-glucose = alpha-D-galactose 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70809", "l": "4-deoxy-4-sulfo-D-erythrulose => 4-deoxy-4-sulfo-D-erythrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0140841", "l": "RNA polymerase II C-terminal domain O-GlcNAc transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36272", "l": "caffeine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43051", "l": "keto-D-tagatose <=> keto-D-sorbose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65607", "l": "(4R)-hydroxysphinganine + eicosanoyl-CoA <=> CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395801", "l": "Phosphorylation of LAT by p-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17321", "l": "L-tryptophan + S-adenosyl-L-methionine = 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.106", "l": "\"tryptophan 2-C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972968", "l": "SALL4 binds the SALL4 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853801", "l": "PSPN binds RET:GFRA4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130706", "l": "MHC class II antigen processing (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691004", "l": "XPC binds RAD23 and CETN2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956659", "l": "ABL1 phosphorylates YAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31019", "l": "4 AH2 + all-trans-4,4'-diapolycopene + 4 O2 = 4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O", "d": []}, {"i": "EC:1.14.99.44", "l": "\"diapolycopene oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38939", "l": "dioscin + 2 H2O = diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose", "d": []}, {"i": "EC:3.2.1.190", "l": "\"dioscin glycosidase (3-O-beta-D-Glc-diosgenin-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2514865", "l": "cGMP dissociates from CNG channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60465", "l": "2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371537", "l": "DBC1 binds SIRT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25418", "l": "(9Z)-octadecenoyl-CoA + A + 2 H2O => AH2 + O2 + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61999", "l": "L-lysyl-[protein] + lactoyl-CoA <=> CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008898", "l": "S-adenosylmethionine-homocysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730872", "l": "Activation of Calcineurin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42306", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19749", "l": "[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.183", "l": "\"alpha-1,3-glucan synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810643", "l": "EPPIN protein complex binds bacteria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72607", "l": "(E)-sinapoyl-AMP + CoA = (E)-sinapoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68259", "l": "L-cystine(in) + Na(+)(in) <=> L-cystine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451033", "l": "(S)-Malate <=> Fumarate + H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74960", "l": "(3R)-3-isocyanylbutanoate + ATP + holo-[ACP] => (3R)-3-isocyanylbutanoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61393", "l": "ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604368", "l": "Autocatalytic activation of bound proMMP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61328", "l": "O2 + parthenolide + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24746", "l": "L-methionine = 2-aminobut-2-enoate + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55815", "l": "a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58611", "l": "2 L-ascorbate + N-decanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67948", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47788", "l": "a cytidine in 28S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11535", "l": "glycine + H2O + O2 <=> glyoxylate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28635", "l": "(2E,6E)-farnesyl diphosphate = (+)-5-epi-aristolochene + diphosphate", "d": []}, {"i": "EC:4.2.3.61", "l": "\"5-epiaristolochene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13914", "l": "L-threonine => D-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73786", "l": "dimethylallyl diphosphate + tardioxopiperazine A <=> diphosphate + echinulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11101", "l": "4-hydroxyhexan-3-one => 2 propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730887", "l": "Autophosphorylation and activation of MEKK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044653", "l": "dextrin alpha-glucosidase activity", "d": ["Catalysis of the reaction: dextrin + H2O = alpha-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879910", "l": "JAK2 is phosphorylated, activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56014", "l": "beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59050", "l": "CO2 + putrescine => D-ornithine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800793", "l": "PIDD1 translocates to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33172", "l": "D-maltose(in) => D-maltose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63732", "l": "UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan O-beta-D-glucuronoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12240", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)", "d": []}, {"i": "EC:2.3.1.165", "l": "\"6-methylsalicylic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46249", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (14Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15673", "l": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.11", "l": "\"acetoacetyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014610", "l": "Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24453", "l": "L-glutamyl-[protein] + S-adenosyl-L-methionine => [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50194", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70941", "l": "L-methionine(out) => L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14853", "l": "4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl-CoA + chloride + H(+)", "d": []}, {"i": "EC:3.8.1.7", "l": "\"4-chlorobenzoyl-CoA dehalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56582", "l": "6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine => 6-thioguanine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40487", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102170", "l": "5-epi-aristolochene-1,3-dihydroxylase activity", "d": ["Catalysis of the reaction: (+)-5-epi-aristolochene + 2 NADPH + 2 H+ + 2 O2 <=> capsidiol + 2 NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28290", "l": "(2E,6E)-farnesyl diphosphate + H2O = (5S,9S,10S)-drim-7-en-11-ol + diphosphate", "d": []}, {"i": "EC:4.2.3.194", "l": "\"(-)-drimenol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57457", "l": "(E)-sinapate + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52794", "l": "Mg(2+) + pheophorbide a => chlorophyllide a + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42469", "l": "2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O => 2-oxopent-4-enoate + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687520", "l": "MetAsp transforms to L-Asp,isoAsp (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52715", "l": "dTMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419389", "l": "LPA-binding receptors bind LPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.13.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033134", "l": "ubiquitin activating enzyme binding", "d": ["Binding to a ubiquitin activating enzyme, any of the E1 proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65735", "l": "2-oxoglutarate + heptyl sulfate + O2 <=> CO2 + H(+) + heptanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31836", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-3-dehydro-6-deoxy-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67368", "l": "H2O + N-acetyl-L-glutamine = acetate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57716", "l": "hydrogencarbonate + NH4(+) = carbamate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48757", "l": "erythritol + NAD(+) => D-erythrulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12911", "l": "2 Fe(III)-[cytochrome] + H2O + nitrite => 2 Fe(II)-[cytochrome] + 2 H(+) + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45423", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine <=> a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62711", "l": "(indol-3-yl)butanoate + UDP-alpha-D-glucose <=> 4-(indol-3-yl)butanoyl-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18523", "l": "2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine => licodione + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420883", "l": "Opsins act as GEFs for G alpha-t (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59845", "l": "(+)-dehydrodiconiferyl alcohol + H(+) + NADPH => (R)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14928", "l": "D-mannitol 1-phosphate + NADP(+) <=> D-mannose 6-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72492", "l": "citrate(out) + maleate(in) => citrate(in) + maleate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218812", "l": "FYN phosphorylates PAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193700", "l": "p75NTR ICD signals to NF-kB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40083", "l": "hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61610", "l": "[DsbB protein]-disulfide + a quinol => [DsbB protein]-dithiol + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9035484", "l": "CysS248-MPST:TXN2 dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66715", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13053", "l": "L-phenylalanine + pyruvate = 3-phenylpyruvate + L-alanine", "d": []}, {"i": "EC:2.6.1.58", "l": "\"phenylalanine(histidine) transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58656", "l": "a 5'-end (5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine = a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374896", "l": "Uptake of Noradrenaline (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473511", "l": "Collagen type XXIII binds Integrin alpha2beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11787", "l": "H2O + L-aspartate + NADP(+) <=> H(+) + NADPH + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10458", "l": "1-O-acetylmaltose + CoA => acetyl-CoA + D-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55521", "l": "dimethylallyl diphosphate + 3 isopentenyl diphosphate => 3 diphosphate + nerylneryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57566", "l": "7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35774", "l": "5-deoxy-5-amino-3-dehydroshikimate <=> 3-amino-5-hydroxybenzoate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9617595", "l": "SGTA binds mislocalized membrane protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50964", "l": "cytidine(8) in tRNA + H(+) + H2O = NH4(+) + uridine(8) in tRNA", "d": []}, {"i": "EC:3.5.4.35", "l": "\"tRNA(cytosine(8)) deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-606349", "l": "Mis18 complex binds the centromere (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879221", "l": "PSTPIP1 binds Pyrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75325", "l": "chloride(in) + D-leucine(in) + 2 Na(+)(in) => chloride(out) + D-leucine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68306", "l": "3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45096", "l": "(9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43177", "l": "cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38493", "l": "(9Z)-octadecenoate + glycerol + H(+) => 2-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666430", "l": "p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2995334", "l": "COX15 transforms heme O to heme A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62449", "l": "holo-[peptidyl-carrier protein] + L-glutamyl-5'-AMP => AMP + H(+) + L-glutamyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3700981", "l": "TP53 family members bind the BAX promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357432", "l": "AXL binds SRC-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71947", "l": "N-acetyl-L-aspartate(out) + 3 Na(+)(out) = N-acetyl-L-aspartate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25493", "l": "(2E)-geranyl diphosphate => (-)-beta-phellandrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46688", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA + A = 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16664", "l": "fluoride + S-adenosyl-L-methionine <=> 5'-deoxy-5'-fluoroadenosine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18651", "l": "2-dehydro-3-deoxy-D-galactonate + H2O => D-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70448", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + O2 => a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008802", "l": "betaine-aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15922", "l": "2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.16", "l": "\"methylthioadenosine nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31929", "l": "2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39701", "l": "(2E,13Z)-eicosadienoyl-CoA + H2O => (R)-3-hydroxy-(13Z)-eicosenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249378", "l": "STING recruits TBK1 and STAT6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604752", "l": "Initial activation of proMMP13 by MMP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54471", "l": "1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034861", "l": "benzothiazole-2-sulfonate hydrolase activity", "d": ["Catalysis of the reaction: benzothiazole-2-sulfonate + H2O = 2-hydroxybenzothiazole + HSO3-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49464", "l": "2,6-dihydroxybenzoate + H(+) = CO2 + resorcinol", "d": []}, {"i": "EC:4.1.1.103", "l": "\"gamma-resorcylate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66363", "l": "(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O <=> (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159796", "l": "Furin cleaves pro-factor IX to factor IX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2255342", "l": "RALA exchanges GDP for GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39714", "l": "O2 + 2 reduced coenzyme F420-(gamma-L-Glu)(n) <=> 2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380586", "l": "loading of Serotonin in synaptic vesicles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46425", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018807", "l": "RAC3 GDIs block activation of RAC3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418845", "l": "Activation of caspase-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60976", "l": "(E)-4-hydroxynon-2-en-1-ol + NAD(+) = (E)-4-hydroxynon-2-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032441", "l": "pheophorbide a oxygenase activity", "d": ["Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite + oxidized ferredoxin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75607", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = plasmodiophorol B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432164", "l": "Ca2+ influx into the post-synaptic cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418925", "l": "ADORA2A,B bind Ade-Rib (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18666", "l": "(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) => (2R)-3-phosphoglycerate + [phosphate](n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60918", "l": "an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36754", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> beta-D-Gal-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637800", "l": "Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204850", "l": "Interaction of Tie2 and Dok-2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36012", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32297", "l": "2 diphosphate + NADP(+) + squalene => 2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851352", "l": "CCR8 binds CCL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380574", "l": "Dopamine synaptic vesicle docking and priming (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638006", "l": "ARL3 hydrolyzes GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391158", "l": "SIRP alpha binds CD47 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9716913", "l": "ESR1 binds ESR1 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66662", "l": "ADP + beta-D-glucosylceramide(out) + H(+) + phosphate => ATP + beta-D-glucosylceramide(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-481044", "l": "Surface deployment of platelet alpha granule membrane components (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047006", "l": "17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity", "d": ["Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351207", "l": "Spermine  => N-acetylated spermine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52466", "l": "17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP => 17beta-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211247", "l": "Cleavage of DNA by DFF40 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204861", "l": "Interaction of Tie2 and Shc1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47445", "l": "3-oxo-(7Z-hexadecenoyl)-CoA + CoA => (5Z)-tetradecenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40679", "l": "(9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878054", "l": "HIPK2 phosphorylates RUNX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15342", "l": "ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide => ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29618", "l": "alpha-maltotriose + beta-maltose <=> alpha-maltotetraose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111238", "l": "Formation of ADAR2  homodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0030226", "l": "apolipoprotein receptor activity", "d": ["Combining with an apolipoprotein to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67177", "l": "H2O + primary fluorescent dioxobilin-type chlorophyll catabolite => H(+) + methanol + O13(4)-desmethyl pFDCC", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035143", "l": "NR1H2,3 binds the APOC4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678925", "l": "NR3C1 binds NR3C1 agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75532", "l": "AH2 + N-acetyl-S-hydroxy-L-cysteine => A + H2O + N-acetyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12915", "l": "(R)-lipoyl-5'-AMP + diphosphate => (R)-lipoate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64102", "l": "H(+) + S-adenosyl-L-homocysteine + TAN-1612 => 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112385", "l": "Addition of nucleotides leads to transcript elongation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696323", "l": "CNRs bind CNR agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5228992", "l": "ROCK1,ROCK2 are activated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23704", "l": "GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate", "d": []}, {"i": "EC:3.5.4.25", "l": "\"GTP cyclohydrolase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611839", "l": "β3-agonists bind ADRB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30493", "l": "2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase] => L-valine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5138459", "l": "WNT5A:FZD4 is endocytosed (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54451", "l": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O <=> a tRNA + an N-acyl-L-amino acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10445", "l": "(S)-reticuline + S-adenosyl-L-methionine => (S)-laudanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.843050782660015", "identifiers": [{"i": "GO:0016722", "l": "oxidoreductase activity, acting on metal ions", "d": ["Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28724", "l": "(S)-allantoin(in) + H(+)(in) => (S)-allantoin(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.10", "l": "\"non-chaperonin molecular chaperone ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43381", "l": "H2O + N(omega)-phospho-L-arginyl-[protein] => L-arginyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798374", "l": "DYRK2 phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62969", "l": "(R)-lactate + NADP(+) => H(+) + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71522", "l": "uridine(out) <=> uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28312", "l": "alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166538", "l": "The bound receptor dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69078", "l": "(R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+) => (R)-noradrenaline + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23686", "l": "allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52443", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose <=> a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53041", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43189", "l": "S-adenosyl-L-methionine + uridine(2634) in 25S rRNA => H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160931", "l": "Disassembly of tight junctions (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55665", "l": "2 AH2 + echinenone + 2 O2 => 2 A + canthaxanthin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416690", "l": "SEMA4A binds to PLXND1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029476", "l": "Role of myosins in phagosome formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192051", "l": "CYP7A1 7-hydroxylates CHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.5", "l": "\"cytidine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26215", "l": "aphidicolan-16beta-ol + diphosphate => 9alpha-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55694", "l": "1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+) => an inositol-1-phosphoceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50947", "l": "3-phenylpropanoate + NAD(+) <=> (E)-cinnamate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46043", "l": "2'-deoxycytidine + ATP <=> ADP + dCMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671993", "l": "CIT-3 binds DLG4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65200", "l": "S-(acetaldehyde)-L-cysteine = (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47728", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70682", "l": "glycine betaine(in) + H(+)(in) <=> glycine betaine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.114", "l": "\"N-acyl-aromatic-L-amino acid amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.12", "l": "\"ABC-type cystine transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58547", "l": "2 L-ascorbate + N-tetradecanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49549", "l": "H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] => H(+) + L-arginyl-[protein] + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034074", "l": "marneral synthase activity", "d": ["Catalysis of the reaction: oxidosqualene = marneral."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51166", "l": "5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674019", "l": "BRAP binds KSR1:MARK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12034", "l": "3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+) => a 3-(acyloxy)acyl derivative of bacterial toxin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69545", "l": "ATP + streptidine => 6-O-adenylylstreptidine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197963", "l": "DHFR2 reduces FOLA to DHF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38856", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050279", "l": "sepiapterin deaminase activity", "d": ["Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23163", "l": "L-rhamnopyranose <=> L-rhamnulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52196", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = 1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19054", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O => H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41006", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42324", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-L-Glu)(n) = 3 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.5.7.2", "l": "\"coenzyme F420 oxidoreductase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16668", "l": "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O <=> (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.87", "l": "\"2-hydroxyisoflavanone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198295", "l": "TRKA phosphorylates IRS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52207", "l": "butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13086", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O => CoA + L-2-acetamido-6-oxoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74125", "l": "pelargonidin 3-O-beta-D-galactoside betaine + UDP => pelargonidin + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16069", "l": "cytidine + H(+) + H2O = NH4(+) + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607023", "l": "factor IXa associates with cell membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160874", "l": "HYAL1 hydrolyses (HA)50 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70782", "l": "D-glucose + NADP(+) <=> 6-dehydro-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.6", "l": "\"endo-1,3(4)-beta-glucanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731931", "l": "EDNRA binds selective ERAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75088", "l": "32-hydroxy-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 32-oxo-24,25-dihydrolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047701", "l": "beta-L-arabinosidase activity", "d": ["Catalysis of the reaction: H2O + a beta-L-arabinoside = L-arabinose + an alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14826", "l": "(1R,5S)-carveol + NAD(+) => (S)-carvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399934", "l": "Phosphorylation of Plexin-A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68069", "l": "a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase] => a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981657", "l": "IL34 dimer binds PTPRZ1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39852", "l": "2 a 1-acyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849908", "l": "SALM4 binds flotillin-1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654224", "l": "Activated FGFR3 binds PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50568", "l": "acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69650", "l": "H2O + quercetin 4'-O-beta-D-glucoside <=> beta-D-glucose + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70063", "l": "a C28-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a (22S)-22-hydroxy C28-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983144", "l": "Transport of Antigen peptide in to ER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64160", "l": "ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide = ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase]", "d": []}, {"i": "EC:6.2.2.1", "l": "\"thioglycine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46032", "l": "H2O2 + tetradecanoate = (2S)-hydroxytetradecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14332", "l": "2-oxoglutarate + O-phospho-L-serine <=> 3-phosphooxypyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22530", "l": "a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP => a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43760", "l": "acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821395", "l": "PAXIP1 binds PAGR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10149", "l": "blasticidin S + H(+) + H2O => deaminohydroxyblasticidin S + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202500", "l": "Activation of IKK complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20924", "l": "a [peptide]-C-terminal (2S)-2-hydroxyglycine = a [peptide]-C-terminal amide + glyoxylate", "d": []}, {"i": "EC:4.3.2.5", "l": "\"peptidylamidoglycolate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54499", "l": "ent-copalyl diphosphate <=> diphosphate + ent-atiserene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56788", "l": "apo-[corrinoid adenosyltransferase] + cob(II)alamin = cob(II)alamin-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18641", "l": "a menaquinone + H2 = a menaquinol", "d": []}, {"i": "EC:1.12.5.1", "l": "\"hydrogen:quinone oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866851", "l": "CFTR transits to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75170", "l": "CTP + NAD(+) <=> CDP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38589", "l": "devancoaminyl-vancomycin + UDP => UDP-alpha-D-glucose + vancomycin aglycone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684140", "l": "ATM phosphorylates RBBP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40735", "l": "(20S)-ginsenoside Rb1 + 2 H2O = 2 D-glucose + gypenoside LXXV", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57162", "l": "(3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11128", "l": "4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5225649", "l": "RBBP7 binds histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63260", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH = 4-pyridoxate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44419", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15670", "l": "a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP => a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38502", "l": "a triacyl-sn-glycerol + H2O <=> a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696356", "l": "OSCAR binds collagen and SP-D (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52983", "l": "a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165680", "l": "Formation of active mTORC1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027373", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.98.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433578", "l": "phytoceramide + H2O => stearate + phytosphingosine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34090", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol <=> a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782943", "l": "UV-DDB ubiquitinates XPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854222", "l": "TBC1D3 associates with RAB5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39548", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA => (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53387", "l": "5,10-methylenetetrahydromethanopterin + NAD(+) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66548", "l": "3'-phosphoadenylyl sulfate + 4-nitrophenol = 4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17547", "l": "[protein]-disulfide + ADP + phosphate + S-hydroxy-L-cysteinyl-[peroxiredoxin] => [protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296326", "l": "HCAR1 binds LACT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156682", "l": "PLK1 phosphorylates NUDC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28208", "l": "ADP + dUMP + H(+) => 2'-deoxyuridine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047149", "l": "thetin-homocysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: L-homocysteine + dimethylsulfonioacetate = (methylthio)acetate + L-methionine + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008084", "l": "imaginal disc growth factor receptor binding", "d": ["Binding to an imaginal disc growth factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252001", "l": "ATP1B4 binds SNW1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637770", "l": "Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357483", "l": "RAC1 binds PAK1-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67254", "l": "3-oxopropanoate + 2 H(+) + NADH => H2O + malonaldehyde + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61491", "l": "cytidine(50) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74088", "l": "an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP => ADP + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45221", "l": "coenzyme M + methyl-Co(III)-[trimethylamine-specific corrinoid protein] => Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34647", "l": "S-adenosyl-L-methionine + squalene = 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788867", "l": "FN3K phosphorylates ketosamines (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388817", "l": "ICOS binds ICOSL/B7-H2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46601", "l": "[HPr protein]-L-serine + ATP => [HPr protein]-O-phospho-L-serine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205306", "l": "Interaction of SHP1 and KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54522", "l": "cycloaraneosene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16173", "l": "(4-hydroxyphenyl)acetaldehyde + dopamine = (S)-norcoclaurine + H2O", "d": []}, {"i": "EC:4.2.1.78", "l": "\"(S)-norcoclaurine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19198", "l": "adenosine 5'-phosphosulfate + NH4(+) => adenosine 5'-phosphoramidate + 2 H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51258", "l": "(9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49078", "l": "dibenzothiophene 5-oxide + FMN + H(+) + H2O => dibenzothiophene + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917841", "l": "Acidification of Tf:TfR1 containing endosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41977", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) => CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50641", "l": "2-(2-methylsulfanyl)ethylmalate => 3-(2-methylsulfanyl)ethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.30.1", "l": "\"Aspergillus nuclease S1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22627", "l": "(S)-4-hydroxy-2-oxopentanoate <=> acetaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51084", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45756", "l": "(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.76", "l": "\"prenyl-diphosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.5.1", "l": "\"nitrilase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102631", "l": "caffeoylglucose 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: 1-O-caffeoyl-beta-D-glucose + S-adenosyl-L-methionine <=> 1-O-feruloyl-beta-D-glucose + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.218", "l": "\"phenylpropanoylacetyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53467", "l": "1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35501", "l": "glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2255343", "l": "RAB8A,10,13,14 exchange GDP for GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46708", "l": "2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase] = AMP + H(+) + salicyl-[non-ribosomal peptide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12845", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O = [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate", "d": []}, {"i": "EC:3.4.15.6", "l": "\"cyanophycinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993784", "l": "Conjugation of SUMO2 to UBA2:SAE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38506", "l": "1,3-diacyl-sn-glycerol + H2O <=> a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55117", "l": "5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807106", "l": "PTEN undergoes monoubiquitination (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033455", "l": "GCA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GCA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57639", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate <=> holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.28", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693598", "l": "ATM phosphorylates NBN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44661", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine => 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404135", "l": "RBP4 binds atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684169", "l": "G6B binds PTPN6,PTPN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706304", "l": "Active FLT3 binds to GRAP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38618", "l": "cyclic ADP-beta-D-ribose + H2O <=> ADP-D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252072", "l": "AZGP1 binds PIP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432378", "l": "Nuclear JET binds CRY, facilitating its ubiquitination (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047127", "l": "thiomorpholine-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.2", "l": "\"guanosine-3',5'-bis(diphosphate) 3'-diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189439", "l": "ALAD condenses 2 dALAs to form PBG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972965", "l": "POU5F1 (OCT4), SOX2, NANOG bind the TSC22D1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74546", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (E,E,E)-alpha-springene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50837", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 => 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23354", "l": "L-glutamate + succinate semialdehyde => 2-oxoglutarate + 4-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66702", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140260", "l": "mitochondrial proton-transporting ATP synthase complex binding", "d": ["Binding to a mitochondrial proton-transporting ATP synthase complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63500", "l": "H(+) + NADPH + S-nitrosoglutathione = NADP(+) + sulfinamide glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799466", "l": "TP53I3 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10366", "l": "(3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+) => 2-oxoglutarate + dodecanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691154", "l": "HFE binds TFRC dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611277", "l": "P2RY12 binds P2RY12 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60432", "l": "A + cannabigerolate = AH2 + cannabichromenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52444", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose = 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.295", "l": "\"2-methyl-6-phytyl-1,4-hydroquinone methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047575", "l": "4-carboxymuconolactone decarboxylase activity", "d": ["Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H+ = 5-oxo-4,5-dihydro-2-furylacetate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33423", "l": "N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) = diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.196", "l": "\"protein-N(pi)-phosphohistidine--N,N'-diacetylchitobiose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41257", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508451", "l": "PTK2B is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62859", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72107", "l": "Na(+)(out) + O-acyl-(R)-carnitine(out) = Na(+)(in) + O-acyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190256", "l": "FGFR1c binds to FGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48793", "l": "GDP-beta-L-fucose + Lc4Cer => alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74944", "l": "2-oxoglutarate + a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + O2 => a (3R)-3-isocyanyl-fatty acid + 2 CO2 + 2 H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52951", "l": "deoxycholate + UDP-alpha-D-glucuronate <=> deoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68446", "l": "(3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenal => 5-cis-lycopene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18311", "l": "a carboxylate + a D-alpha-amino acid => an N-acyl-D-amino acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9650858", "l": "Meglitinides bind ABCC8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004139", "l": "deoxyribose-phosphate aldolase activity", "d": ["Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112037", "l": "Inactivation of PLC beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5627775", "l": "Autophosphorylation of PAK1,2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949343", "l": "ITGAL gene,(ITGA4 gene) expression is stimulated by RUNX3:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12971", "l": "an alcohol + H(+) + sn-glycerol 3-phosphate => a sn-glycero-3-phosphodiester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1370500", "l": "PRLR binds SCF beta-TrCP complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74442", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) <=> a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62322", "l": "(+)-isomalbrancheamide B + FADH2 => (+)-premalbrancheamide + chloride + FAD + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823959", "l": "SMAD2,3 and GATA6-AS1 lncRNA bind the GATA6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615490", "l": "p-S133-CREB1 binds MIR132 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111970", "l": "PKC phosphorylates GRK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5140741", "l": "WNT5A binds FZD and ROR receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818937", "l": "MEN1 binds MLL1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.863640214551324", "identifiers": [{"i": "GO:0019902", "l": "phosphatase binding", "d": ["Binding to a phosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33611", "l": "H2O + methyl salicylate = H(+) + methanol + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38138", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67022", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29250", "l": "3 H(+)(out) + 2 Na(+)(in) <=> 3 H(+)(in) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052740", "l": "1-acyl-2-lysophosphatidylserine acylhydrolase activity", "d": ["Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65665", "l": "citrate(out) + 4 Na(+)(out) => citrate(in) + 4 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48895", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O <=> L-threonyl-[protein] + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433711", "l": "Cis-homodimerization of nectins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421835", "l": "trans-Golgi Network Vesicle Scission (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11703", "l": "H(+) + NADPH + O2 + progesterone <=> H2O + NADP(+) + testosterone acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655320", "l": "Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18834", "l": "4-formylbenzenesulfonate + H2O + NAD(+) => 4-sulfobenzoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.217", "l": "\"exo-acting protein-alpha-N-acetylgalactosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19233", "l": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]", "d": []}, {"i": "EC:3.1.2.22", "l": "\"palmitoyl-protein hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19311", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate => 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22431", "l": "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 <=> 2 H2O + isopenicillin N", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58145", "l": "acetate + ATP + cytidine(34) in elongator tRNA(Met) => AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625409", "l": "KLF4 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76079", "l": "a dicarboxylate(in) + L-sepiapterin(out) = a dicarboxylate(out) + L-sepiapterin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353265", "l": "Interaction between two DNA-PK:DNA complexes at opposing ends of DNA DSB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39856", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol => a triacyl-sn-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56147", "l": "a quinol + nitrate <=> a quinone + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10814", "l": "2 H(+) + N-succinyl-L-glutamate + NADH => H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67796", "l": "a ribonucleotidyl-ribonucleotide-RNA = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40824", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.79", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0022883", "l": "zinc efflux transmembrane transporter activity", "d": ["Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047812", "l": "D-amino-acid N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino-acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675417", "l": "PEBP1 binds activated RAF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443439", "l": "c-Src binds Raf1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51096", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10116", "l": "6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009558", "l": "IL34 dimer binds SDC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12437", "l": "(E)-caffeoyl-CoA + putrescine => CoA + H(+) + N-caffeoylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191299", "l": "Squalene is oxidized to its epoxide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38392", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5229343", "l": "AXIN is phosphorylated in the destruction complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782234", "l": "Recovery of RNA synthesis after TC-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11432", "l": "S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.153", "l": "\"vitexin 2''-O-rhamnoside 7-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654167", "l": "Activated FGFR1 binds PLCG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250600", "l": "botD:SV2:GD2 internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63689", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58395", "l": "4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72044", "l": "L-glutamate(in) + orotate(out) => L-glutamate(out) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58684", "l": "FAD + 2 H(+) + NADPH + O2 = FADH2-C4alpha-hydroperoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928577", "l": "ROCK phosphorylates LIMK1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31496", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851298", "l": "GPR143 binds L-Dopa (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32144", "l": "L-arginine(in) => L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797090", "l": "CCNK binds CDK12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39067", "l": "3-oxooctanedioyl-CoA + CoA = acetyl-CoA + hexanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165162", "l": "Phosphorylation of TSC2 by PKB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804266", "l": "CHEK2 phosphorylates TTC5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11528", "l": "2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514790", "l": "Elastin degradation by MMP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19951", "l": "7,8-dihydropteroate + diphosphate => (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38563", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190141", "l": "ALAD binds to Pb2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37775", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18840", "l": "10-deacetyltaxuyunnanin C + acetyl-CoA <=> CoA + taxuyunnanin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15061", "l": "2 a Fe(II)-siderophore + H(+) + NAD(+) = 2 a Fe(III)-siderophore + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16230", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) => a CDP-1,2-diacyl-sn-glycerol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016768", "l": "spermine synthase activity", "d": ["Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2471842", "l": "Collagen type XXV ectomain shedding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50654", "l": "2-(2-methylsulfanyl)propylmaleate + H2O => 2-(3-methylsulfanyl)propylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062147", "l": "L-lysine 4-chlorinase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + chloride + H+ + L-lysine + O2 = 4-chloro-L-lysine + CO2 + H2O + succinate."]}, {"i": "RHEA:59884", "l": "2-oxoglutarate + chloride + H(+) + L-lysine + O2 = 4-chloro-L-lysine + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112727", "l": "Serine phosphorylation of STATs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55965", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726621", "l": "PGR binds PGR antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140090", "l": "membrane curvature sensor activity", "d": ["Preferential binding of proteins on curved membranes. The binding to curved membranes by insertion (aka wedging) to curved membranes is mediated by both the hydrophobic and hydrophilic faces of the helix of membrane curvature sensing (MCS) proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714580", "l": "SLC6A3 binds DRIs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22750", "l": "2 pyruvate => 4-hydroxy-4-methyl-2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333607", "l": "GSSeH combines with bGalNAc derivative to form GSSebGalNac (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50460", "l": "a medium chain fatty acid + ATP + holo-[ACP] = a medium-chain fatty acyl-[ACP] + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.47", "l": "\"medium-chain-fatty-acid--[acyl-carrier-protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034002", "l": "(R)-limonene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = (4R)-limonene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70731", "l": "4-aminobutanoate(out) + chloride(out) + 3 Na(+)(out) = 4-aminobutanoate(in) + chloride(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381612", "l": "GLP1R binds GLP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72121", "l": "(R)-carnitine(out) + glycine betaine(in) => (R)-carnitine(in) + glycine betaine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53833", "l": "2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 => a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102417", "l": "apigenin-7-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: apigenin 7-O-beta-D-glucoside + UDP-alpha-D-glucose <=> apigenin-7-O-gentiobioside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353023", "l": "3-phosphoglycerate + ATP <=> 1,3-bisphosphoglycerate + ADP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76054", "l": "(S)-scoulerine + S-adenosyl-L-methionine <=> (S)-cis-N-methylscoulerine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70152", "l": "6-deoxo-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-norcastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36073", "l": "D-glucose + tulipalin A => 6-tuliposide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.70", "l": "\"sortase A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395364", "l": "LTBP4 binds TGF-Beta-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9793485", "l": "PRKN polyubiquitinates RIPK3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65374", "l": "CMP + globoside MSGG + H(+) => CMP-N-acetyl-beta-neuraminate + globoside GalGb4Cer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39285", "l": "a long-chain fatty acid(in) => a long-chain fatty acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11300", "l": "1D-5-O-methyl-myo-inositol + NAD(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.143", "l": "\"sequoyitol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16935", "l": "2-oxobutanoate + NH4(+) => 1-aminocyclopropane-1-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23437", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O => 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.19", "l": "\"procollagen C-endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66655", "l": "(2E,6E)-farnesyl diphosphate <=> african-1-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53139", "l": "(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) <=> 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.839897517610368", "identifiers": [{"i": "GO:0004521", "l": "RNA endonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785181", "l": "LMF1,2 bind LIPC dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59363", "l": "carnosine + H2O <=> beta-alanine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33101", "l": "CoA + H(+) + N(1)-acetylspermine => acetyl-CoA + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030747", "l": "indolepyruvate C-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (indol-3-yl)pyruvate = S-adenosyl-L-homocysteine + (S)-3-(indol-3-yl)-2-oxobutanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29725", "l": "glyoxylate(out) => glyoxylate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391372", "l": "GNRHR binds GNRH1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112690", "l": "PTPN11 binds CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71874", "l": "(S)-3-hydroxybutanoate(out) + H(+)(out) <=> (S)-3-hydroxybutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68795", "l": "alpha-NAD(+) + H2O <=> ADP-D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33782", "l": "6-kestotriose + sucrose <=> 6,6-kestotetraose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173739", "l": "Spontaneous hydrolysis of C3 thioester (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814374", "l": "Kazrin binds periplakin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39780", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52093", "l": "5-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682026", "l": "MRN bound to shortened telomeres activates ATM (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46895", "l": "2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate <=> 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201457", "l": "BMP2 binds to the receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848776", "l": "PTK6 phosphorylates DOK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60386", "l": "N-(2,3-dihydroxybenzoyl)-L-serine trimer => enterobactin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990935", "l": "splicing factor binding", "d": ["Binding to a protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-517674", "l": "p-S158,221-HuR binds mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31222", "l": "5-hydroxykynurenamine + CO2 <=> 5-hydroxy-L-kynurenine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663426", "l": "sCD163 binds MYH9 in T-cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34208", "l": "3-O-alpha-D-glucosyl-L-rhamnose + phosphate => beta-D-glucose 1-phosphate + L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592398", "l": "Activation of proMMP8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57464", "l": "(E)-caffeate + UDP-alpha-D-glucose = 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420688", "l": "GABAB heterodimeric receptor binds GABA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70248", "l": "N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose => beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097383", "l": "dIDP phosphatase activity", "d": ["Catalysis of the reaction: dIDP + H2O = dIMP + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0046027", "l": "phospholipid:diacylglycerol acyltransferase activity", "d": ["Catalysis of the reaction: phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31687", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35168", "l": "minocycline(in) => minocycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22178", "l": "20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67137", "l": "3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41604", "l": "1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22539", "l": "(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine <=> (S)-tetrahydropalmatine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58235", "l": "L-seryl-[protein] + NAD(+) <=> H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41300", "l": "H2O + N-(9Z-octadecenoyl)-sphing-4-enine => (9Z)-octadecenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687097", "l": "p-S857 NCOA3 binds ETV4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64389", "l": "4 A + sn-3-O-phytanylglycerol 1-phosphate => 4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61849", "l": "cholesterol + UDP-alpha-D-glucose => cholesteryl 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374663", "l": "DCC interaction with Ezrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65102", "l": "an hexadecanoyl-acylglycerol + CoA => a 1-acylglycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37686", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA <=> 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.155", "l": "\"xyloglucan-specific endo-processive beta-1,4-glucanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33061", "l": "(R)-lipoamide + H(+) + NADH => (R)-dihydrolipoamide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39069", "l": "acetyl-CoA + hexanedioyl-CoA => 3-oxooctanedioyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45632", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72486", "l": "(S)-malate(in) + citrate(out) <=> (S)-malate(out) + citrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4167511", "l": "HLCS biotinylates ACACB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34164", "l": "hydroquinone + O2 => (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32495", "l": "(2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase] = (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.83", "l": "\"geraniol 8-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27958", "l": "cytidine + H2O = cytosine + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374298", "l": "Opioid receptors bind opioid peptides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50765", "l": "4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine => 4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13313", "l": "H2O + O2 + sarcosine = formaldehyde + glycine + H2O2", "d": []}, {"i": "EC:1.5.3.1", "l": "\"sarcosine oxidasee (formaldehyde-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5333678", "l": "CPNEs bind PL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445064", "l": "Activation of Rac1 by VAV2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75483", "l": "estrone 3-sulfate(out) + n H(+)(out) = estrone 3-sulfate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0017076", "l": "purine nucleotide binding", "d": ["Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45286", "l": "CoA + H(+) + N-eicosanoyl-sphing-4-enine => eicosanoyl-CoA + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24291", "l": "5-formimidoyltetrahydrofolate + glycine <=> (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853496", "l": "SCF:FBXL7 binds AURKA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50233", "l": "8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374298", "l": "Opioid receptors bind opioid peptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433823", "l": "Released NFkB complex migrates to the nucleus and turns on transcription (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47389", "l": "a tetradecanoate ester + H2O => an aliphatic alcohol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607734", "l": "PKC-delta translocates to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52800", "l": "acetoacetyl-CoA + ATP + L-isoleucine = AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid", "d": []}, {"i": "EC:6.3.2.50", "l": "\"tenuazonic acid synthetase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56682", "l": "H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003680", "l": "minor groove of adenine-thymine-rich DNA binding", "d": ["Binding to a DNA structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990595", "l": "mast cell secretagogue receptor activity", "d": ["Combining with basic secretagogues to initiate pseudo-allergic reactions in mast cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874187", "l": "MBTPS2 (S2P) cleaves CREB3L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380272", "l": "Plk1-mediated phosphorylation of Nlp (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205306", "l": "Interaction of SHP1 and KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15956", "l": "agmatine + ATP <=> ADP + 2 H(+) + N(4)-phosphoagmatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76020", "l": "cortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 18-hydroxycortisol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473584", "l": "Collagen type III degradation by MMP15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53534", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694455", "l": "SUMO-p-N protein dimer binds genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20936", "l": "2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507719", "l": "p62:MEKK3 binds to TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45264", "l": "(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)-octadecadienoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654224", "l": "Activated FGFR3 binds PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602458", "l": "Activation of proMMP10 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687088", "l": "PKA phosphorylates MAPKAPK5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20641", "l": "H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH", "d": []}, {"i": "EC:1.1.1.23", "l": "\"histidinol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74066", "l": "2-aminoisobutanoate(out) + L-alanine(in) <=> 2-aminoisobutanoate(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39987", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030986", "l": "low molecular weight kininogen binding", "d": ["Binding to a kininogen of low molecular mass."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32498", "l": "(2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351894", "l": "Caspase mediated cleavage of BAP31 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296043", "l": "Activation of HCN channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15193", "l": "dGTP + H2O = 2'-deoxyguanosine + H(+) + triphosphate", "d": []}, {"i": "EC:3.1.5.1", "l": "\"dGTPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49084", "l": "(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] = (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.72", "l": "\"(-)-pluviatolide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.805366613539277", "identifiers": [{"i": "GO:0015399", "l": "primary active transmembrane transporter activity", "d": ["Enables the transfer of a solute from one side of a membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source. Primary energy sources known to be coupled to transport are chemical such as ATP hydrolysis, redox energy and photon energy."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202947", "l": "Caspase mediated cleavage of APC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018494", "l": "FOXA1 and GATA3 bind TFF genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980130", "l": "NOTCH1 binds DLK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50183", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-507868", "l": "Aquaporins passively transport water into cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23767", "l": "diphosphate + L-serine <=> H(+) + O-phospho-L-serine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37897", "l": "26-deglucoprotodioscin + D-glucose => H2O + protodioscin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046424", "l": "ferulate 5-hydroxylase activity", "d": ["Catalysis of the reaction: ferulic acid + NADPH + H+ + O2 = 5-hydroxyferulic acid + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72568", "l": "dehydroepiandrosterone 3-sulfate(in) + propanoate(out) => dehydroepiandrosterone 3-sulfate(out) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327746", "l": "FN1 aggregation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40274", "l": "O2 + tetradecanedioyl-CoA <=> (2E)-tetradecenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20783", "l": "ATP + GMP <=> ADP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9670673", "l": "FIX is secreted (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62530", "l": "dihydrodigoxin + 2 Fe(III)-[cytochrome c] => digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799199", "l": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803998", "l": "Nitrite ion and HNO2 form a conjugated acid-base pair (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27481", "l": "(S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase] = acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.148", "l": "\"angelicin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3321883", "l": "MSL acetylates histone H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43973", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63280", "l": "a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36815", "l": "dTDP-alpha-D-fucose = dTDP-alpha-D-fucofuranose", "d": []}, {"i": "EC:5.4.99.59", "l": "\"dTDP-fucopyranose mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170978", "l": "p-FRS2:CRKL binds C3G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25953", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde => 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26345", "l": "L-galactonate + NADP(+) = aldehydo-D-galacturonate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.365", "l": "\"D-galacturonate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14861", "l": "(S)-dihydroorotate + NADP(+) = H(+) + NADPH + orotate", "d": []}, {"i": "EC:1.3.1.15", "l": "\"dihydroorotate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944262", "l": "Association of procollagen type X (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10269", "l": "2-dehydro-3-deoxy-D-glucarate => 2-hydroxy-3-oxopropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40880", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9017797", "l": "NOTCH3 binds YBX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75831", "l": "5-oxo-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] = 5-oxo-18-hydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624953", "l": "ARL13B binds INPP5E (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034808", "l": "benzo(a)pyrene 4,5-dioxygenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-4,5-dihydrodiol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534359", "l": "CatSper Channel Mediated Calcium Transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73405", "l": "(2R,3R)-tartrate(out) + sulfate(in) => (2R,3R)-tartrate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51467", "l": "deoxycholate + O2 + reduced [NADPH--hemoprotein reductase] <=> 1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74986", "l": "Elongation of pre-rRNA transcript (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16036", "l": "2-oxoglutarate + gibberellin A44 + O2 <=> CO2 + gibberellin A19 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1449687", "l": "Corticosteroids bind to CBG in blood (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047725", "l": "inulosucrase activity", "d": ["Catalysis of the reaction: sucrose + 2,1-beta-D-fructosyl(n) = glucose + 2,1-beta-D-fructosyl(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58227", "l": "L-glutamyl-[protein] + NAD(+) <=> 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64015", "l": "acetyl-CoA + AH2 + 3 malonyl-CoA + 3 S-adenosyl-L-methionine <=> A + 3 CO2 + 4 CoA + fumigermin + H2O + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10300", "l": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430135", "l": "p-SLP-76 binds ADAP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59004", "l": "dodecanal + H2O + O2 = dodecanoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13550", "l": "beta-L-fucose 1-phosphate + GTP + H(+) => diphosphate + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69534", "l": "4-amino-4-deoxychorismate => (2S)-2-amino-4-deoxychorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59260", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25677", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3244643", "l": "STING binds cyclic GMP-AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35719", "l": "(3S)-versiconol acetate + H2O = (S)-versiconol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63593", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64689", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418925", "l": "ADORA2A,B bind Ade-Rib (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675194", "l": "Activated MAPK phosphorylates RAF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712087", "l": "ALK fusions phosphorylate FRS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592316", "l": "Initial activation of proMMP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004828", "l": "serine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18863", "l": "a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine => a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16438", "l": "glutathione + RX => a halide anion + an S-substituted glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351201", "l": "N-acetylated spermidine (cytosol)=>N-acetylated spermidine (peroxisomal) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408500", "l": "GSSeH condenses with GSH to form H2Se and GSSG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801666", "l": "PLK2 phosphorylates CENPJ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426223", "l": "Cation influx mediated by TRPC3/6/7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13052", "l": "D-glucuronate <=> D-fructuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088130", "l": "PLK1 binds FOXM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31251", "l": "(S)-3-hydroxyisobutanoyl-CoA + H2O = (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28809", "l": "L-cysteinylglycine + L-glutamate => glutathione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2129353", "l": "Tropoelastin associates with microfibrils (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11214", "l": "2-formamidobenzaldehyde => indole + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205306", "l": "Interaction of SHP1 and KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944223", "l": "Association of procollagen type V (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947541", "l": "Sulfhydrylation and ring cleavage of precursor Z (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047703", "l": "beta-nitroacrylate reductase activity", "d": ["Catalysis of the reaction: 3-nitropropanoate + NADP+ = 3-nitroacrylate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10967", "l": "ATP + D-xylulose <=> ADP + D-xylulose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21357", "l": "L-arabinitol + NAD(+) => H(+) + L-ribulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24693", "l": "acetate + eugenol + NADP(+) <=> (E)-coniferyl acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66543", "l": "7-dehydrocholesterol + A + H2O <=> AH2 + cholesta-5,7-dien-3beta,25-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15186", "l": "L-arginine + succinyl-CoA => CoA + H(+) + N(2)-succinyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57302", "l": "a 2'-deoxyguanosine in DNA + H(+) + lactate => an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132248", "l": "C4b binds to target cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5631941", "l": "SESN1,2,3 bind AMPK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18784", "l": "H(+) + malonyl-CoA <=> acetyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37690", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-141437", "l": "Formation of the MCC complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32845", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034813", "l": "benzo(a)pyrene 7,8-dioxygenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-7,8-dihydrodiol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62295", "l": "(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) <=> 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13429", "l": "2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate", "d": []}, {"i": "EC:2.7.7.60", "l": "\"2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210277", "l": "Interaction of PECAM-1 and SHP-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389532", "l": "PP2A binds CTLA4 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139906", "l": "Activation of BAD by calcineurin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033930", "l": "keratan-sulfate endo-1,4-beta-galactosidase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in keratan sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68334", "l": "(R)-pantothenate + phosphate => (R)-4'-phosphopantothenate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44633", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + O2 => 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46745", "l": "ATP + hydrogencarbonate => ADP + carboxyphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22945", "l": "3beta-hydroxy-5beta-pregnane-20-one + NADP(+) => 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22613", "l": "(3S)-citramalyl-CoA => acetyl-CoA + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426209", "l": "DAG activation of TRPC channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759356", "l": "NFE2L2-dependent GSTA3 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938815", "l": "RNF152 polyubiquitinates RRAGA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186798", "l": "GAP binds to PDGF-beta receptors only (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031219", "l": "levanase activity", "d": ["Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606624", "l": "Active FLT3:GRB2 binds GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0140721", "l": "nuclease inhibitor activity", "d": ["Binds to and modulates the activity of a nuclease."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19724", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683964", "l": "ATM phosphorylates EYA1-4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000403", "l": "Y-form DNA binding", "d": ["Binding to a DNA segment shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29251", "l": "2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700184", "l": "Ligand-independent dimerization of point mutants of ALK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30735", "l": "1D-myo-inositol 4-phosphate + H2O = myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13060", "l": "an N-acylneuraminate 9-phosphate + H2O <=> an N-acylneuraminate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54730", "l": "malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] => acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34385", "l": "beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP => alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.92", "l": "\"peptidoglycan beta-N-acetylmuramidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202966", "l": "Caspase mediated cleavage of HIP-55 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19475", "l": "3,4-dihydroxybenzoate + H2O + NAD(+) => 4-hydroxybenzoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047760", "l": "butyrate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070043", "l": "rRNA (guanine-N7-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N7-methylguanine."]}, {"i": "REACT:R-HSA-6790982", "l": "WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013284", "l": "NOTCH3-ligand complex is cleaved to produce NEXT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818574", "l": "TASP1 cleaves KMT2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050097", "l": "methylaspartate mutase activity", "d": ["Catalysis of the reaction: threo-3-methyl-L-aspartate = L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13088", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O <=> CoA + L-2-acetamido-6-oxoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39631", "l": "(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH = (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69933", "l": "inosine(in) + Na(+)(in) => inosine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.1", "l": "\"alcohol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692315", "l": "OX40L binds OX40 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33065", "l": "NADH + 2 oxidized [2Fe-2S]-[putidaredoxin] => H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39839", "l": "a 2,3-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50404", "l": "(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] = 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18000", "l": "Co-precorrin-2 + S-adenosyl-L-methionine <=> Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0003978", "l": "UDP-glucose 4-epimerase activity", "d": ["Catalysis of the reaction: UDP-glucose = UDP-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49239", "l": "N(pros)-phospho-L-histidyl-[protein](out) + sucrose <=> L-histidyl-[protein] + sucrose 6(G)-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67528", "l": "(6Z)-octenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(6Z-octenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961920", "l": "E2F1 binds the CDK1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46753", "l": "7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22859", "l": "(7S)-salutaridinol + acetyl-CoA <=> (7S)-O-acetylsalutaridinol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0016211", "l": "ammonia ligase activity", "d": ["Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944262", "l": "Association of procollagen type X (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016295", "l": "myristoyl-[acyl-carrier-protein] hydrolase activity", "d": ["Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25439", "l": "(2E,6E)-farnesyl diphosphate <=> (E,R)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66593", "l": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA => a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43157", "l": "guanosine(9) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75461", "l": "(9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63793", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13902", "l": "H2O + N-(aminomethyl)urea => N-(hydroxymethyl)urea + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58760", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59790", "l": "(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH => H2O + NAD(+) + pseudopaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64351", "l": "2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+) <=> deacetylpyripyropene E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22819", "l": "alpha-D-xylose <=> alpha-D-xylulofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71777", "l": "acetoacetate(in) + H(+)(in) => acetoacetate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940561", "l": "MMP7 cleaves OPTC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56395", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40581", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+) => 1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507875", "l": "Aquaporins passively transport urea into cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38301", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354073", "l": "Autophosphorylation of PTK2 at Y397 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72355", "l": "dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18993", "l": "(9Z,12Z)-octadecadienoate + O2 = (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": []}, {"i": "EC:1.13.11.45", "l": "\"linoleate 11-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33838", "l": "H2O + N-hexacosanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + hexacosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68215", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoylglycerol <=> 1,2-dihexanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549304", "l": "OCT3 mediates renal clearance of organic cations (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30644", "l": "phosphate + S-methyl-5'-thioinosine => hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015018", "l": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432909", "l": "Interaction of Plectin with Integrin beta 4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31413", "l": "a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48972", "l": "ATP + H2O + phosphite(out) = ADP + H(+) + phosphate + phosphite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56037", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203979", "l": "Coat Assembly (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686587", "l": "ABL1 phosphorylates RAD52 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20067", "l": "3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate => 2'-deoxymugineate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24193", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) => (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11708", "l": "H2O + IMP + NAD(+) = H(+) + NADH + XMP", "d": []}, {"i": "EC:1.1.1.205", "l": "\"IMP dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0035325", "l": "Toll-like receptor binding", "d": ["Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52248", "l": "6 H2O + 4 Mn(3+) + O2 = 12 H(+) + 4 MnO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74415", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607744", "l": "MALT1 binds BCL10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73739", "l": "dopamine(in) + 2 H(+)(out) = dopamine(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12647", "l": "(indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047921", "l": "aminoglycoside 2'-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + gentamicin C(1a) = N(2')-acetylgentamicin C(1a) + CoA + H+. This is acetylation of the 2'-amino group of the 6-deoxy-6-aminoglucose ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984606", "l": "Kinesin-5 is a homotetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23314", "l": "1(F)-beta-D-fructosylsucrose + D-glucose => 2 sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37773", "l": "1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54409", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43887", "l": "3-oxochol-4-en-22-oyl-CoA + NAD(+) <=> 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45484", "l": "H(+) + pyruvate = acetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42460", "l": "dibenzofuran + H(+) + NADH + O2 = biphenyl-2,2',3-triol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004382", "l": "GDP phosphatase activity", "d": ["Catalysis of the reaction: GDP + H2O = GMP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60861", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725117", "l": "ALK gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48560", "l": "H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70083", "l": "hydroxyclavatol = H2O + o-quinone methide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050065", "l": "lysine-pyruvate 6-transaminase activity", "d": ["Catalysis of the reaction: L-lysine + pyruvate = L-alanine + L-allysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10105", "l": "2-oxoglutarate + gibberellin A20 + O2 => CO2 + gibberellin A1 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482770", "l": "Release of platelet secretory granule components (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55530", "l": "(4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-tyrosine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43366", "l": "beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP => L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008480", "l": "sarcosine dehydrogenase activity", "d": ["Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3828025", "l": "DCN (decorin) degradation by MMP14 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58648", "l": "rifamycin SV hemiaminal = H(+) + rifamycin SV ortho-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51944", "l": "8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine = 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.343", "l": "\"8-amino-8-demethylriboflavin N,N-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73617", "l": "CTP(in) + dCMP(out) => CTP(out) + dCMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71050", "l": "Trimerization of the FASL:FAS receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672011", "l": "p-AMPK:AMP binds the ULK complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16141", "l": "2'-deoxymugineate + NAD(+) = 3''-deamino-3''-oxonicotianamine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139899", "l": "Sequestration of BAD protein by 14-3-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102263", "l": "tRNA-dihydrouridine17 synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil17 in tRNA + NAD(P) = H+ + a uracil17 in tRNA + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805126", "l": "AURKB phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73590", "l": "CTP(out) + UMP(in) <=> CTP(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55796", "l": "H(+) + NADH + O2 + phenol = H2O + hydroquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034015", "l": "L-ribulose-5-phosphate 3-epimerase activity", "d": ["Catalysis of the reaction: L-ribulose 5-phosphate = L-xylulose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56588", "l": "a monosubstituted aliphatic (S)-hydroxynitrile = an aldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710101", "l": "CASP4, CASP5 cleave GSDMD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5681987", "l": "LC3 is cleaved by ATG4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114254", "l": "CYCS binds to APAF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75631", "l": "H2O + plasmodiophorol B = plasmodiophorol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21464", "l": "2 H(+) + H2O + thiocyanate = carbonyl sulfide + NH4(+)", "d": []}, {"i": "EC:3.5.5.8", "l": "\"thiocyanate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54196", "l": "N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617829", "l": "Assembly of IFT A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12372", "l": "2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O = 4-oxohex-2-enedioate + H(+)", "d": []}, {"i": "EC:3.1.1.45", "l": "\"carboxymethylenebutenolidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433961", "l": "Activated TLR homo- or heterodimer recruits adaptors TIRAP(or MAL) and MyD88 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38370", "l": "8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA <=> 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68099", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O <=> a 3'-end ribonucleotide-RNA + a 5'-end (5'-phospho)-ribonucleoside-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618328", "l": "ATAT acetylates microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22946", "l": "5beta-pregnan-3,20-dione + H(+) + NADPH => 3beta-hydroxy-5beta-pregnane-20-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59955", "l": "2,6-dimethylheptanoyl-CoA + H2O <=> 2,6-dimethylheptanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27820", "l": "2-dehydro-L-idonate + H(+) + NADH => L-idonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10180", "l": "(6S)-10-formyltetrahydrofolate + H2O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH", "d": []}, {"i": "EC:1.5.1.6", "l": "\"formyltetrahydrofolate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614669", "l": "FASLG gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75731", "l": "(10S)-hydroxy-(12Z)-octadecenoate + NAD(+) = 10-oxo-(12Z)-octadecenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44209", "l": "12-methyltridecanoate + ATP + CoA => 12-methyltridecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.55", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202604", "l": "Formation of a heteromeric BMP receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.139", "l": "\"pterocarpan synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683718", "l": "Protein M localizes to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64794", "l": "2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+) => L-lysine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8873850", "l": "STARD5 binds DCA, LCA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46329", "l": "L-threo-3-phenylserine => 3-phenylpyruvate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807565", "l": "GNLY is transferred to the phagosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749505", "l": "LRRC14 binds IKBKB and CHUK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23191", "l": "NAD(+) + propane-1,3-diol <=> 3-hydroxypropanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10597", "l": "ATP + L-tyrosyl-[protein] => ADP + H(+) + O-phospho-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433488", "l": "Phosphorylation of SHP2 by SFKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49048", "l": "25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28070", "l": "(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o", "d": []}, {"i": "EC:2.5.1.141", "l": "\"heme o synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54370", "l": "acetoin + CO2 => acetaldehyde + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25855", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762343", "l": "PREDL:ALB dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41206", "l": "1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0033878", "l": "hormone-sensitive lipase activity", "d": ["Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0008527", "l": "taste receptor activity", "d": ["Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35529", "l": "N-ethylsuccinimide + NAD(+) => H(+) + N-ethylmaleimide + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73005", "l": "(R)-benzodiazepinedione + 2 AMP + 2 diphosphate + H(+) => anthranilate + 2 ATP + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71896", "l": "dGTP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66207", "l": "heptanoyl-CoA + O2 <=> (2E)-heptenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043749", "l": "phenol, water dikinase activity", "d": ["Catalysis of the reaction: phenol + MgATP + H2O = phenylphosphate + MgAMP + orthophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805276", "l": "CDK5 phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51813", "l": "ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33451", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] = AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49764", "l": "ethylenediaminetriacetate + FMNH2 + O2 = ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706399", "l": "RHOBTB3 hydrolyzes ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036383", "l": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58026", "l": "H(+) + oleanolate 3-O-beta-D-glucoside + UDP => oleanolate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683751", "l": "M protein gets N-glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54614", "l": "2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylbutanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36413", "l": "calciol => 7-dehydrocholesterol + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37182", "l": "(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate <=> (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782820", "l": "USP17 deubiquitinates SUDS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199203", "l": "PANK1/3/4 phosphorylate PanK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38369", "l": "18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA => 8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34812", "l": "NADP(+) + tetrahydrocurcumin => dihydrocurcumin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665989", "l": "DIAPH1 binds RHOA:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004617", "l": "phosphoglycerate dehydrogenase activity", "d": ["Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9652264", "l": "ERBB2 binds TKIs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799332", "l": "ATR phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43890", "l": "[sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine => [sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134953", "l": "DHX36 or DHX9 binds MyD88 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23997", "l": "a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005469", "l": "succinate:fumarate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72240", "l": "estrone 3-sulfate(out) + L-glutamate(in) => estrone 3-sulfate(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27733", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) <=> beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9625482", "l": "PTK2 binds activated EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69004", "l": "3-amino-2-hydroxy-4-methoxybenzoate + ATP + nitrite = AMP + cremeomycin + diphosphate + H2O", "d": []}, {"i": "EC:6.7.1.1", "l": "\"3-amino-2-hydroxy-4-methoxybenzoate diazotase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69817", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + teasterone => cathasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59110", "l": "beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol => chenodeoxycholate + octyl beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65752", "l": "2-oxoglutarate + L-glutamate + O2 = (3R)-3-hydroxy-L-glutamate + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.76", "l": "\"L-glutamate 3(R)-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77081", "l": "Formation of the CE:GMP intermediate complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22192", "l": "(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": []}, {"i": "EC:2.1.2.3", "l": "\"phosphoribosylaminoimidazolecarboxamide formyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41541", "l": "8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine => 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702583", "l": "crenolanib-resistant FLT3 mutants don't bind crenolanib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13540", "l": "(2R)-3-phosphoglycerate + GDP-alpha-D-mannose <=> 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814094", "l": "ARL1:GTP binds ARFIP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64434", "l": "H(+)(in) + L-alanyl-L-prolylglycine(in) => H(+)(out) + L-alanyl-L-prolylglycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14963", "l": "formate + glutathione + H(+) => H2O + S-formylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37679", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173740", "l": "Factor B binds to C3(H2O) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30049", "l": "chloroacetate + 2 H(+) + NADH => chloroacetaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212432", "l": "Formation of DRIP coactivator complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551648", "l": "SUMOylation of TDG with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11871", "l": "D-arabinitol + NADP(+) <=> D-ribulose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29577", "l": "L-serine(out) + Na(+)(out) => L-serine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24257", "l": "ATP + kanamycin A => ADP + H(+) + kanamycin 3'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62791", "l": "2 fonsecin B + H(+) + NADPH + O2 <=> aurasperone B + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71849", "l": "LDH tetramer reduces PYR to LACT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.48", "l": "\"heme oxygenase (staphylobilin-producing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59013", "l": "cycloartenol + S-adenosyl-L-methionine => 24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23412", "l": "H2O + N-acetylputrescine = acetate + putrescine", "d": []}, {"i": "EC:3.5.1.62", "l": "\"acetylputrescine deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26027", "l": "H2O + N(1)-acetylspermidine + O2 = 3-aminopropanal + H2O2 + N-acetylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11417", "l": "2 1-O-galloyl-beta-D-glucose => 1,6-bis-O-galloyl-beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026771", "l": "DPEP hydrolyses MCTR2 to MCTR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981657", "l": "IL34 dimer binds PTPRZ1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45610", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine => H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102700", "l": "alpha-thujene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate(3-) <=> alpha-thujene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28556", "l": "D-mannose + phosphate => D-mannose 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16495", "l": "glycerol 1-phosphate + H(+) => glycerol 1,2-cyclic phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52022", "l": "A + H2O + resolvin E2 => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27657", "l": "2-oxobutanoate + H(+) + pyruvate <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42482", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+) => 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111956", "l": "Calmodulin activates Cam-PDE 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951552", "l": "LTF:2xCO3(2-) dissociates from Carbocymycobactin:Fe3+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032358", "l": "oxidized pyrimidine DNA binding", "d": ["Binding to a DNA region containing an oxidized pyrimidine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33817", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+) => CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031800", "l": "type 3 metabotropic glutamate receptor binding", "d": ["Binding to a type 3 metabotropic glutamate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37784", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63445", "l": "(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin => GMP + H(+) + oxidized coenzyme F420-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30726", "l": "A + 2 ADP + H(+) + NH4(+) + 2 phosphate <=> AH2 + 2 ATP + H2O + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19712", "l": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22614", "l": "acetyl-CoA + pyruvate => (3S)-citramalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44448", "l": "an acyl-CoA + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17068", "l": "(R)-mevalonate + ATP <=> (R)-5-phosphomevalonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417927", "l": "P2Y2 receptor binds ATP and UTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40228", "l": "3'-phosphoadenylyl sulfate + desulfo-A47934 => A47934 + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0061811", "l": "ADP-ribosyl cyclase activity", "d": ["Catalysis of the reaction: NAD = cyclic ADP-ribose + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45907", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine <=> dTDP + epivancomycin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72023", "l": "nicotinate(in) + urate(out) = nicotinate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218642", "l": "PTK2 autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033959", "l": "deoxyribodipyrimidine endonucleosidase activity", "d": ["Catalysis of the cleavage of the N-glycosidic bond between the 5'-pyrimidine residue in cyclobutadipyrimidine (in DNA) and the corresponding deoxy-D-ribose residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60167", "l": "a guanosine in RNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25767", "l": "3-carboxy-2-oxobutanoate + H(+) = 2-oxobutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71474", "l": "H2O + substance P <=> L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209297", "l": "PYGO binds to the LGS:ARM complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21546", "l": "(2E,6E)-farnesyl triphosphate + ADP => (2E,6E)-farnesyl diphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40361", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692764", "l": "MAPK6 binds CCND3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75856", "l": "Abortive Initiation Before Second Transition (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465883", "l": "VTN binds collagens I, IV and VI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62251", "l": "chloroacetaldehyde + H2O + NADP(+) <=> chloroacetate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27563", "l": "(2E)-geranyl diphosphate + 7 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 7 diphosphate", "d": []}, {"i": "EC:2.5.1.84", "l": "\"all-trans-nonaprenyl-diphosphate synthase [geranyl-diphosphate specific]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29035", "l": "ATP + H2O + L-glutamate(out) = ADP + H(+) + L-glutamate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821486", "l": "HCFC1 binds SET1A complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69597", "l": "AMP + inosine => adenosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69313", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate => benzyl thiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71051", "l": "L-leucine(out) + L-methionine(in) = L-leucine(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955844", "l": "RBKS phosphorylates ribose to R5P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31729", "l": "(2S)-2-phenyloxirane + FAD + H(+) + H2O => FADH2 + O2 + styrene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419011", "l": "Transhomodimerization of Nectins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389862", "l": "Conversion of glyoxylate to oxalate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161979", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35371", "l": "2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) = (beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218824", "l": "p-6Y-VEGFR2 binds FYN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191656", "l": "Closure of gap junction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709831", "l": "HSP90 binds TBK1 and IRF3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614933", "l": "ACEIs bind ACE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22324", "l": "H2O + leukotriene A4 = leukotriene B4", "d": []}, {"i": "EC:3.3.2.6", "l": "\"leukotriene-A4 hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47665", "l": "H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) => 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43936", "l": "androst-5-ene-3,17-dione = androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2248891", "l": "Active ARSA translocates to the lysosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11357", "l": "A + H(+) + NADH => AH2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374662", "l": "Translocation of Ezrin to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52510", "l": "13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26451", "l": "CoA + NADP(+) + succinate semialdehyde => H(+) + NADPH + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433940", "l": "Association of LBP with bacterial LPS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39789", "l": "19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19339", "l": "2 H(+) + hyponitrous acid + 2 NADH => 2 hydroxylamine + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687095", "l": "p-S215 FOXO3 binds MIR34B and C gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12737", "l": "5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine = [PrdC protein]-L-selenocysteine/L-cysteine + D-proline", "d": []}, {"i": "EC:1.21.4.1", "l": "\"D-proline reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61801", "l": "ATP + holo-[peptidyl-carrier protein] + L-alanine => AMP + diphosphate + L-alanyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052686", "l": "perillic acid-CoA ligase (AMP-forming) activity", "d": ["Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + AMP + diphosphate + perillyl-CoA."]}, {"i": "KEGG.REACTION:R06368", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749215", "l": "MCM8 binds CDC6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071950", "l": "FADH2 binding", "d": ["Binding to the reduced form, FADH2, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682992", "l": "KDM4A,B bind H4K20Me2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67288", "l": "ATP + 12 H(+) + L-leucine + 8 malonyl-CoA + 9 NADPH + 4 S-adenosyl-L-methionine = (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + AMP + 8 CO2 + 8 CoA + diphosphate + 7 H2O + 9 NADP(+) + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9010872", "l": "SLIT2 binds Dystroglycan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734687", "l": "ORC6 is phosphorylated on T195 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051477", "l": "mannosylglycerate transmembrane transporter activity", "d": ["Enables the transfer of a mannosylglycerate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161962", "l": "LTA4 is hydrolysed to 6t-/6t,12epi-LTB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420688", "l": "GABAB heterodimeric receptor binds GABA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37808", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38166", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46898", "l": "a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.1.11", "l": "\"6-deoxy-5-ketofructose 1-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61310", "l": "germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675198", "l": "Activated MAPKs phosphorylate BRAF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58660", "l": "a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-methionine = a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32942", "l": "a 1,2-diacyl-sn-glycerol + CDP-choline <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72862", "l": "3',3',3'-c-tri-AMP + H2O <=> A[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193812", "l": "Efflux of 27-hydroxycholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67639", "l": "(2S)-2-amino-2'-deoxyadenylo-succinate <=> dZMP + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9615348", "l": "AGT(34-41) binds to AGTR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004782", "l": "sulfinoalanine decarboxylase activity", "d": ["Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.106", "l": "\"hepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797961", "l": "CHDH oxidises Cho to BETALD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54259", "l": "2-oxoglutarate + L-histidyl-[protein] + O2 <=> (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086410", "l": "CDK1 phosphorylates BORA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451461", "l": "IRAK4 binds to the activated TLR7 or 21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72336", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + syringate => 3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008842", "l": "diphosphate-purine nucleoside kinase activity", "d": ["Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693243", "l": "RHOD translocates to the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49214", "l": "20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51039", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 <=> 2 H2O + indole-3-pyruvate imine dimer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59077", "l": "bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose => 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40022", "l": "ent-copalyl diphosphate + H2O <=> (-)-ent-copalol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212614", "l": "Glutamine transport from astrocytes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18955", "l": "H(+) + NADPH + sepiapterin => L-erythro-7,8-dihydrobiopterin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047469", "l": "4-carboxymethyl-4-methylbutenolide mutase activity", "d": ["Catalysis of the reaction: 4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16408", "l": "benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) <=> benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004027", "l": "alcohol sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9660557", "l": "RAS:GTP binds RAL GDS proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008666", "l": "2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity", "d": ["Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = L-2-succinylamino-6-oxopimelate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38266", "l": "(2R,3S)-beta-methylmalyl-CoA <=> 2-methylfumaryl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14343", "l": "2-hydroxy-3-oxoadipate + CO2 => 2-oxoglutarate + glyoxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004773", "l": "steryl-sulfatase activity", "d": ["Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45941", "l": "12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72514", "l": "(R)-carnitine(out) + 2-oxoglutarate(in) <=> (R)-carnitine(in) + 2-oxoglutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35479", "l": "(1'S,5'R)-5'-hydroxyaverantin + NAD(+) = (S)-5'-oxoaverantin + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35795", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine = H(+) + kanamycin A + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45467", "l": "eicosanoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z)-eicosenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29383", "l": "dIMP + H2O = 2'-deoxyinosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68995", "l": "3-amino-4-hydroxybenzoate + H(+) + NADPH + O2 <=> 3-amino-2,4-dihydroxybenzoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68914", "l": "DNA polymerase alpha:primase binds at the origin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55576", "l": "4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine = H(+) + psilocybin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33571", "l": "A + methanol = AH2 + formaldehyde", "d": []}, {"i": "EC:1.1.99.37", "l": "\"methanol dehydrogenase (nicotinoprotein)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114560", "l": "Adhesion of integrin alphaIIbbeta3 to fibrin network (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38201", "l": "19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66003", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32088", "l": "[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate => [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68162", "l": "H(+) + H2O + N-(8'-hydroxygeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase] => N-geranyl-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44080", "l": "ATP + CoA + undecanoate = AMP + diphosphate + undecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51013", "l": "a monoacyl-sn-glycero-3-phosphocholine + H2O => a monoacylglycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806974", "l": "MET dimers autophosphorylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73861", "l": "1-methylnicotinamide(in) => 1-methylnicotinamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10159", "l": "dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] <=> 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265301", "l": "Corticotropin cleavage from POMC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67707", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41029", "l": "1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10872", "l": "H2O + N-acyl-L-aspartate = a carboxylate + L-aspartate", "d": []}, {"i": "EC:3.5.1.15", "l": "\"aspartoacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692809", "l": "CDC42 binds effectors at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38529", "l": "(9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+) => 1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64310", "l": "acetoacetate + L-alanine => 3-aminobutanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46098", "l": "4 CO2 + 4 CoA + dihydropinosylvin => 3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37662", "l": "anthraniloyl-CoA + methanol <=> CoA + O-methyl anthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28913", "l": "H(+)(in) + L-lysine(in) => H(+)(out) + L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31588", "l": "FMNH2 + NADH + O2 + uracil => (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019855", "l": "calcium channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a calcium channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34938", "l": "2 ATP + H(+) <=> diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106029", "l": "tRNA pseudouridine synthase activity", "d": ["Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62892", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA = 6 CO2 + 7 CoA + 2 H2O + nor-toralactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45296", "l": "a sphingosylphosphocholine + H2O = a sphingoid base + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65678", "l": "a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327733", "l": "FN1 binds Collagen types I-V, VII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604752", "l": "Initial activation of proMMP13 by MMP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70914", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44847", "l": "(R)-carnitine + eicosanoyl-CoA <=> CoA + O-eicosanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17232", "l": "acetyl-CoA + an aliphatic alcohol <=> an acetyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004353", "l": "glutamate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418456", "l": "cGMP is degraded by PDEs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71840", "l": "dehydroepiandrosterone 3-sulfate(out) => dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14788", "l": "RNA(n) + UTP <=> diphosphate + RNA(n)-3'-uridine ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671839", "l": "Phosphorylated STAT3 Dissociates from Leptin Receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036056", "l": "Defective HGSNAT does not acetylate Heparan sulfate chain(3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18304", "l": "ATP + NH4(+) + XMP <=> AMP + diphosphate + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40121", "l": "CoA + H(+) + tetradecanoate => H2O + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551648", "l": "SUMOylation of TDG with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67345", "l": "kaempferol 7-O-beta-D-glucoside + malonyl-CoA => CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.28", "l": "\"picornain 3C\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66952", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose = alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.377", "l": "\"dTDP-Rha:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-rhamnosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29747", "l": "3-phenylpropanoate(in) = 3-phenylpropanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102646", "l": "14betaH-scalarane-17alpha-19-diol synthase activity", "d": ["Catalysis of the reaction: 14betaH-scalarane-17alpha-19-diol <=> all-trans-geranylfarnesol + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.50", "l": "\"C-glycoside oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.30", "l": "\"phycobiliprotein beta-cysteine-155 phycobilin lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191737", "l": "Docking of connexons into junctional, double-membrane spanning channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050610", "l": "methylarsonate reductase activity", "d": ["Catalysis of the reaction: 2 glutathione + H+ + methylarsonate = glutathione disulfide + H2O + methylarsonous acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14882", "l": "3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+) => asparagusate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46552", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.39", "l": "\"acyl-lipid Delta(12)-acetylenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114352", "l": "Sequestration of tBID by BCL-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873946", "l": "OTUD3 deubiquitinates PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938773", "l": "RNF144A polyubiquitinates PRKDC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050512", "l": "lactosylceramide 4-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67128", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH = (1R,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390835", "l": "DRD1,5 bind DA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36449", "l": "ADP + glycyl-L-proline(in) + H(+) + phosphate => ATP + glycyl-L-proline(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191830", "l": "snRNP nuclear import and release (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177920", "l": "Binding of GRB2 to GAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043365", "l": "[formate-C-acetyltransferase]-activating enzyme activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.4", "l": "\"3-oxosteroid 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12391", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613451", "l": "p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396379", "l": "NOTCH1 Coactivator Complex binds HES5 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21951", "l": "formamide + H2O <=> formate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858270", "l": "HILPDA binds lipid droplets (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31983", "l": "abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031870", "l": "thromboxane A2 receptor binding", "d": ["Binding to a thromboxane A2 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940561", "l": "MMP7 cleaves OPTC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41827", "l": "3-oxohexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyhexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848395", "l": "IL18:IL18R1 binds IL18RAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5631941", "l": "SESN1,2,3 bind AMPK (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14451", "l": "3,8-divinyl chlorophyllide a + H(+) + NADPH => chlorophyllide a + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627107", "l": "XIAP binds CASP7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74716", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine => 3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59904", "l": "H2O + NADP(+) + octanal = 2 H(+) + NADPH + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56042", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0120016", "l": "sphingolipid transfer activity", "d": ["Removes a sphingolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47202", "l": "(24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH => (24S)-7alpha-dihydroxycholesterol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22867", "l": "L-lysine <=> D-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-398040", "l": "Gbeta:gamma activation of PLC beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11544", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine = H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine", "d": []}, {"i": "EC:3.5.1.26", "l": "\"N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60180", "l": "ATP + D-fructose(out) + H2O = ADP + D-fructose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62846", "l": "beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+) => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0048029", "l": "monosaccharide binding", "d": ["Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62462", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate => 3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15815", "l": "CoA + N-acetylimidazole => 1H-imidazole + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46686", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2 => 3-oxochol-4-en-24-oyl-CoA + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3204303", "l": "MRE11 binds cytosolic DNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706298", "l": "Active FLT3 binds to CSK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67499", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O <=> 3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706364", "l": "Internalization of ubiquitinated FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694442", "l": "CNIH2,3 bind GRIA1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14489", "l": "a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72909", "l": "D-mannose(in) + Na(+)(in) => D-mannose(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19914", "l": "a (3R)-hydroxyacyl-[ACP] + NAD(+) => a 3-oxoacyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427570", "l": "Group 3 - Selective Cl- transport (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31253", "l": "(S)-3-hydroxy-2-methylpropanoate + CoA + H(+) => (S)-3-hydroxyisobutanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73084", "l": "chrysoeriol + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + velutin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15614", "l": "NAD(+) + precorrin-2 => 2 H(+) + NADH + sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47487", "l": "deoxycholate + NAD(+) <=> 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55944", "l": "2-chloroethanol + 2 Fe(III)-[cytochrome c] = chloroacetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674019", "l": "BRAP binds KSR1:MARK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033719", "l": "2-oxo-acid reductase activity", "d": ["Catalysis of the reaction: a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20464", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine <=> an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050376", "l": "UDP-glucosamine 4-epimerase activity", "d": ["Catalysis of the reaction: UDP-glucosamine = UDP-galactosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44474", "l": "1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine => 1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17401", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = 4-carboxy-2-hydroxy-cis,cis-muconate + H2O", "d": []}, {"i": "EC:4.2.1.83", "l": "\"4-oxalmesaconate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54890", "l": "AMP + diphosphate + OPC8-CoA => (1S,2S)-OPC-8 + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68680", "l": "3'-phosphoadenylyl sulfate + 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(beta-D-glucuronate) = 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141341", "l": "SMOX-3 oxidises SPN to SPM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16646", "l": "H2O + hexadecanoyl-CoA => CoA + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683765", "l": "Nucleoprotein translocates to the ERGIC outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69178", "l": "2-hydroxy-2-methylpropanoate + L-lysyl-[protein] => H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48214", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine => a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70895", "l": "N-terminal L-cysteinyl-[protein] + O2 = H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57776", "l": "2-chloro-6-nitrotoluene + NADH + O2 = 4-chloro-3-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944266", "l": "Association of procollagen type XI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42204", "l": "corticosterone + NAD(+) = 11-dehydrocorticosterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629203", "l": "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070700", "l": "BMP receptor binding", "d": ["Binding to a BMP receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400143", "l": "Fatty acid ligands activate PPARA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42722", "l": "2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2552) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340385", "l": "HAVCR2 binds LGALS9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196773", "l": "COASY phosphorylates DP-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76386", "l": "CYP1A2 S-demethylates 6MMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781905", "l": "ZRANB1 binds APC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661419", "l": "ALB binds extracellular heme (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33028", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene => 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010489", "l": "UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity", "d": ["Catalysis of the reaction: UDP-4-keto-6-deoxyglucose = UDP-4-keto-rhamnose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34258", "l": "sporulenol <=> (R)-tetraprenyl-beta-curcumene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047115", "l": "trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity", "d": ["Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72343", "l": "3-methoxyphenol + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + resorcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9656947", "l": "OGG1beta translocates to mitochondria (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46028", "l": "H2O2 + tetradecanoate = (2R)-hydroxytetradecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28477", "l": "D-glucarate(in) + H(+)(in) <=> D-glucarate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693575", "l": "DNA-PKcs autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16846", "l": "acetyl-CoA + H2O + oxaloacetate => citrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38988", "l": "nonanoyl-CoA + O2 => (2E)-nonenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31460", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate => 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46005", "l": "2-methylpropanal + CoA + NAD(+) => 2-methylpropanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74399", "l": "2 (S)-lactate(in) + prostaglandin F2alpha(out) = 2 (S)-lactate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990882", "l": "CDK1 phosphorylates NUP98 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38162", "l": "(2S,3S)-hydroxyarginine <=> (2S,3R)-capreomycidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26390", "l": "all-trans-beta-carotene + O2 => all-trans-10'-apo-beta-carotenal + beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168947", "l": "Ligand binds to TLR10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71660", "l": "a D-glucoside + 2 Fe(III)-[cytochrome c] => a 3-dehydro-D-glucoside + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76416", "l": "Benzene is hydroxylated to phenol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.3.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-167419", "l": "The receptor:G-protein complex releases GDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047604", "l": "acetoin racemase activity", "d": ["Catalysis of the reaction: (S)-acetoin = (R)-acetoin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55833", "l": "cortisone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33138", "l": "malonate(in) + Na(+)(in) <=> malonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47475", "l": "(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH <=> (3E)-tetradecenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0000497", "l": "DNA template activity", "d": ["Binding to nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21724", "l": "a nitrile + 2 H2O = a carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030776", "l": "(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59479", "l": "2 AH2 + 2 ATP + benzoate + L-phenylalanine <=> 2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953013", "l": "E2F7 binds E2F8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10648", "l": "2-hydroxycyclohexan-1-one + H(+) + NADPH + O2 = 6-hydroxyhexan-6-olide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450387", "l": "HuR binds the CRM1 nuclear export machinery (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163689", "l": "Dephosphorylation of pChREBP (Ser 196) by PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71398", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate(out) <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24393", "l": "dTDP-L-dihydrostreptose + streptidine 6-phosphate => dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660829", "l": "ADORA2B binds Ade-Rib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40692", "l": "1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol => 1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863471", "l": "LDLR is bound by DAB2 and ARH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75955", "l": "2-oxoglutarate + O2 + thebaine = CO2 + formaldehyde + oripavine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141040", "l": "very-long-chain 3-oxoacyl-CoA reductase activity", "d": ["Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ = a very-long-chain 3-oxoacyl-CoA + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787737", "l": "CSF3R binds CSF3 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55167", "l": "a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 <=> H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429101", "l": "HMIT co-transports myo-inositol with a proton (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75505", "l": "glycocholate(in) + n H(+)(in) => glycocholate(out) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50291", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1471322", "l": "Beta-defensins are secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141409", "l": "Mad1 binds kinetochore (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36385", "l": "AMP + H(+) + nebramycin 5' => carbamoyl adenylate + tobramycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199425", "l": "PHLPP dephosphorylates S473 in AKT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39259", "l": "(3R)-hydroxy-(13Z)-docosenoyl-CoA = (2E,13Z)-docosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30496", "l": "N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640114", "l": "Misfolded proteins translocate from cilium to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52181", "l": "(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619515", "l": "AMPK phosphorylates MAPT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003945", "l": "N-acetyllactosamine synthase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55165", "l": "a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 => H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61251", "l": "H2O + L-tyrosine + O2 <=> 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28317", "l": "baicalein + UDP-alpha-D-glucuronate <=> baicalin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10600", "l": "prostaglandin H2 = prostaglandin D2", "d": []}, {"i": "EC:5.3.99.2", "l": "\"prostaglandin-D synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16652", "l": "(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47179", "l": "(2R)-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19430", "l": "[beta-adrenergic receptor] + ATP => [beta-adrenergic receptor]-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32014", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-T-muurolol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467811", "l": "Separation of sister chromatids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25726", "l": "L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37301", "l": "L-alanine + L-threonine => H2O + L-alanyl-L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611851", "l": "ADRB2 bind ADR,NAd (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36666", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA <=> (2S,5S)-5-carboxymethylproline + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39165", "l": "(3R)-hydroxyhexadecanoyl-CoA + NADP(+) => 3-oxohexadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021068", "l": "PalmS-ESRs bind CAVs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75258", "l": "mangiferin + O2 <=> 3'-dehydromangiferin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727349", "l": "XDH dehydrogenates xanthine to form urate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-76031", "l": "2 H2O2 => O2 + 2 H2O (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60761", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone => CoA + jasmolin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43975", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694442", "l": "CNIH2,3 bind GRIA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617828", "l": "TRIP11:IFT20 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052828", "l": "inositol-3,4-bisphosphate 4-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445448", "l": "HHIP binds Hedgehog (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750666", "l": "ALB binds ST (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62814", "l": "2 dinapinone A + 2 H2O => 4 monapinone A + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9710959", "l": "p-STAT1 dimer binds KPNA1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17524", "l": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) <=> ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41184", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37459", "l": "1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59584", "l": "ATP + beta-alanine + L-lysine = ADP + beta-alanyl-L-lysine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34091", "l": "(5R)-5-phosphooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate", "d": []}, {"i": "EC:4.2.3.134", "l": "\"5-phosphooxy-L-lysine phospho-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004823", "l": "leucine-tRNA ligase activity", "d": ["Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H+ + Leu-tRNA(Leu)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-438005", "l": "MKK4 phosphorylates JNK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71989", "l": "diphosphate + fusoxypene C => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22673", "l": "2 (2E,6E)-farnesyl diphosphate => diphosphate + presqualene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12645", "l": "CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.2.7.8", "l": "\"indolepyruvate ferredoxin oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29664", "l": "H(+)(in) + xanthine(in) => H(+)(out) + xanthine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624256", "l": "Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62866", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine => 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56309", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-593685", "l": "Netrin-4 binds DCC/UNC5A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191636", "l": "Phosphorylation of Cx43 by c-src (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382057", "l": "Release of novel PDGFs as latent factors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42625", "l": "(Z)-3-ureidoacrylate + H(+) + H2O => (Z)-3-aminoacrylate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43370", "l": "4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA => dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45080", "l": "3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine = ADP + dapdiamide E + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45780", "l": "(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66360", "l": "(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O = (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034925", "l": "pyrene 4,5-monooxygenase activity", "d": ["Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-4,5-oxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432897", "l": "ILK interacts with beta-1 integrin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33406", "l": "ATP + L-threonine <=> diphosphate + L-threonyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31787", "l": "H2O + tuberculosinyl diphosphate = (13R)-edaxadiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64805", "l": "acetyl-CoA + S-(2-aminoethyl)-L-cysteine => CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602484", "l": "Activation of proMMP11 by FURIN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018785", "l": "RHOBTB2 binds GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420233", "l": "VIP receptors bind VIP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862300", "l": "LYZ binds bacterial peptidoglycan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62430", "l": "3,4-dihydroxybenzaldehyde + acetyl-CoA => 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033806", "l": "fluorothreonine transaldolase activity", "d": ["Catalysis of the reaction: L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.243", "l": "\"acyl-Kdo2-lipid IVA acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008577", "l": "IL37:IL18R1 binds SIGIRR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36421", "l": "2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74740", "l": "Binding of SHC1 to insulin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41778", "l": "CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876868", "l": "ECE1 cleaves EDN1(53-90) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026890", "l": "NTRK2 phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68945", "l": "esculetin + S-adenosyl-L-methionine => H(+) + isoscopoletin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203716", "l": "eNOS:Caveolin-1 complex binds to Nostrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46610", "l": "ADP + H(+) + O-phospho-L-threonyl-[protein] => ATP + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68107", "l": "all-trans-zeaxanthin + O2 <=> (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62739", "l": "1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate <=> 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53571", "l": "12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47962", "l": "L-histidyl-[protein] + phosphate => H2O + N(tele)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682967", "l": "WHSC1 binds DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9639286", "l": "RRAGC,D exchanges GTP for GDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34463", "l": "8-hydroxycopalyl diphosphate = cis-abienol + diphosphate", "d": []}, {"i": "EC:4.2.3.140", "l": "\"cis-abienol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2299620", "l": "Collagen XI cross-links with collagen II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34499", "l": "1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] = H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate", "d": []}, {"i": "EC:1.14.15.11", "l": "\"pentalenic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31646", "l": "mycinamicin VI + S-adenosyl-L-methionine <=> H(+) + mycinamicin III + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53120", "l": "(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+) = 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201637", "l": "Caspase-mediated cleavage of plectin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31328", "l": "1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol => bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48216", "l": "H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.31", "l": "\"acyl-lipid (7-3)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373075", "l": "Metabotropic glutamate receptors bind glutamate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209815", "l": "Tyrosine is monoiodinated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22117", "l": "luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate => H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56388", "l": "(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 = (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.202", "l": "\"multisite-specific tRNA:(cytosine-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49855", "l": "(3E)-octenoyl-CoA <=> (2E)-octenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57210", "l": "S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] => glyoxal + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12069", "l": "apo-[ACP] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69482", "l": "beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59514", "l": "O-acetyl-L-seryl-[protein] + salicylate => acetylsalicylate + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23322", "l": "CoA + H(+) + N(2)-malonyl-D-tryptophan => D-tryptophan + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16457", "l": "(2R,3S)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21124", "l": "cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656523", "l": "An anchoring protein ZFYVE9 (SARA) does not recruit SMAD2/3 to TGFB1:TGFBR2:p-TGFBR1 KD Mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6794346", "l": "NRXNs bind NLGNs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209828", "l": "Tryptophan is hydroxylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63145", "l": "H2O + N-(15Z-tetracosenoyl)-ethanolamine => (15Z)-tetracosenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45781", "l": "(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41381", "l": "H(+) + NADH + O2 + toluene => 4-methylphenol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56286", "l": "a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH => a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73010", "l": "D-arabinose 5-phosphate <=> D-glyceraldehyde 3-phosphate + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862184", "l": "USP48 cleaves polyubiquitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.23", "l": "\"tyrosine ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28683", "l": "L-aspartate + ubiquinone-8 = iminosuccinate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045131", "l": "pre-mRNA branch point binding", "d": ["Binding to a pre-mRNA branch point sequence, located upstream of the 3' splice site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37645", "l": "1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009936", "l": "RNASEL cleaves cellular ssRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198508", "l": "MDH1 oxidizes MAL to OA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-481007", "l": "Exocytosis of platelet alpha granule contents (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10118", "l": "CO2 + D-ribulose 5-phosphate + NADPH => 6-phospho-D-gluconate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106281", "l": "chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: chenodeoxycholate + NAD+ = 7-oxolithocholate + H+ + NADH."]}, {"i": "RHEA:42036", "l": "chenodeoxycholate + NAD(+) = 7-oxolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34409", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate => 3 ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48964", "l": "2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61943", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose <=> 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693609", "l": "ATM phosphorylates TP53 at S15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71908", "l": "GDP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695964", "l": "ABHD14B hydrolyses PNPB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9706399", "l": "RHOBTB3 hydrolyzes ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786092", "l": "IL4:IL4R:JAK2 binds IL2RG:JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990606", "l": "membrane scission GTPase motor activity", "d": ["Generation of a 'twisting' activity resulting in the scission of a membrane, driven by GTP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44527", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.343", "l": "\"phosphogluconate dehydrogenase (NAD(+)-dependent, decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36373", "l": "2-oxobutanoate + H(+) + NADH => (2S)-hydroxybutanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40776", "l": "2-amino-2-phenylacetonitrile + H(+) + 2 H2O => D-alpha-phenylglycine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-178208", "l": "SMAD7 binds to SMURF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42191", "l": "3beta-hydroxy-5alpha-androstan-17-one + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448480", "l": "IL22 binds IL22RA1:JAK1 receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.51", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31907", "l": "(S)-norcoclaurine + S-adenosyl-L-methionine = (S)-coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140481", "l": "ABC-type iron-sulfur cluster transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + iron-sulfur cluster(in) = ADP + phosphate + iron-sulfur cluster(out)."]}, {"i": "TCDB:3.A.1.210.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63317", "l": "(9Z,12Z)-octadecadienoate + O2 => 9-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42116", "l": "5alpha-androstane-3alpha,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69977", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.461014234140904", "identifiers": [{"i": "GO:0016857", "l": "racemase and epimerase activity, acting on carbohydrates and derivatives", "d": ["Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12172", "l": "alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)", "d": []}, {"i": "EC:3.5.99.6", "l": "\"glucosamine-6-phosphate deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190260", "l": "FGFR2b binds to FGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141039", "l": "phosphatidylinositol 3-kinase inhibitor activity", "d": ["Binds to and decreases the activity of a phosphatidylinositol 3-kinase (PI3K)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56324", "l": "(2'-deoxyribonucleoside 5'-methylphosphotriester)-DNA + L-cysteinyl-[protein] = 2'-deoxyribonucleotide-DNA + H(+) + S-methyl-L-cysteinyl-[protein]", "d": []}, {"i": "EC:2.1.1.n11", "l": "\"methylphosphotriester-DNA--[protein]-cysteine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56619", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene <=> 1,2,4-trichlorobenzene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247922", "l": "GGCT transforms gGluCys to OPRO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.59", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13735", "l": "an alk-2-enal + H(+) + NADH => an n-alkanal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212222", "l": "PRC2 recruits DNA methyltransferases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70933", "l": "chloride(in) + dopamine(in) + 2 Na(+)(in) => chloride(out) + dopamine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9670673", "l": "FIX is secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43086", "l": "2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15502", "l": "2 L-glutamate + NADP(+) => 2-oxoglutarate + H(+) + L-glutamine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875591", "l": "DOCK7 activates RAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672978", "l": "RAF phosphorylates MAP2K dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73616", "l": "CTP(out) + dCMP(in) => CTP(in) + dCMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63986", "l": "5-hydroxyuridine 5'-phosphate + ADP + H(+) => 5-hydroxyuridine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51326", "l": "(8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31425", "l": "(-)-alpha-cedrene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41986", "l": "acetone + H(+) + NADH => NAD(+) + propan-2-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788061", "l": "Fibronectin degradation by ADAM8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374686", "l": "L1 interaction with Integrins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11316", "l": "an aliphatic aldoxime = a nitrile + H2O", "d": []}, {"i": "EC:4.8.1.2", "l": "\"aliphatic aldoxime dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698043", "l": "FLT3 ITD- and STAT5-dependent CDKN1A gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.214", "l": "\"C7-cyclitol 7-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11538", "l": "glycine betaine + H(+) + 2 H2O2 => choline + H2O + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13590", "l": "3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate => 3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75116", "l": "all-trans-13,14-dihydroretinol + NAD(+) => all-trans-13,14-dihydroretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28859", "l": "Ag(+)(in) + H(+)(in) = Ag(+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23338", "l": "diiodine + 2 H2O => 2 H(+) + H2O2 + 2 iodide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15259", "l": "acetaldehyde + glycine => D-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70971", "l": "citrate <=> isocitrate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38352", "l": "(R)-3-phenyllactate + NAD(+) => 3-phenylpyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43180", "l": "cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.311", "l": "\"25S rRNA (cytosine(2278)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38737", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.27", "l": "\"DNA beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250220", "l": "Homodimerization of ERBB4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13800", "l": "a dolichyl phosphate + H2O <=> di-trans,poly-cis-dolichol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31502", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.95", "l": "\"tocopherol C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426163", "l": "SREBP1A,2 binds the CYP51A1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658438", "l": "SPRED dimer binds NF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0140785", "l": "amino acid sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of an amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68041", "l": "(R)-lanthionine ketimine + 2 H(+) + NADPH => (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41202", "l": "1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428749", "l": "Activated TP receptor binds G-proten Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31020", "l": "4 AH2 + all-trans-4,4'-diapolycopene + 4 O2 => 4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874079", "l": "PTK2 binds activated MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31964", "l": "9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19743", "l": "CoA + formate + H(+) => formyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76117", "l": "6-O-demethylthebaine + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + O2 + thebaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0071723", "l": "lipopeptide binding", "d": ["Binding to a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38159", "l": "(2S,3S)-hydroxyarginine = (2S,3R)-capreomycidine + H2O", "d": []}, {"i": "EC:4.2.1.145", "l": "\"capreomycidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75284", "l": "decanoate + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxydecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870465", "l": "RGGT binds the RAB-binding subunit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74921", "l": "a (2E)-enoyl-[ACP] + AMP + H(+) => a (2E)-2-fatty-enoyl-AMP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008720", "l": "D-lactate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-lactate + NAD+ = H+ + NADH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175117", "l": "1-LTR circle formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0000104", "l": "succinate dehydrogenase activity", "d": ["Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63520", "l": "2-isopropylphenol + H(+) + NADH + O2 = 3-isopropylcatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15610", "l": "ATP + D-ribose 5-phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018863", "l": "phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity", "d": ["Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9(S),10(S)-dihydrodiolphenanthrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634228", "l": "TRAF1 is cleaved by caspases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21949", "l": "formamide + H2O => formate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29807", "l": "ATP + H2O + L-leucine(out) = ADP + H(+) + L-leucine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612639", "l": "NRG2-activated ERBB4 binds GABA receptors through GABRA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168888", "l": "Alpha1-Microglobulin binds heme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451418", "l": "Pellino ubiquitinates IRAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75687", "l": "ATP(in) = ATP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018716", "l": "1-phenanthrol glycosyltransferase activity", "d": ["Catalysis of the reaction: 1-phenanthrol + glucose = 1-phenanthryl-beta-D-glucopyranoside + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418858", "l": "RhoGTPase GEF's recruited to DCC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42452", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate = H2O + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54229", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine => 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24675", "l": "ATP + cytidine => ADP + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9796617", "l": "MIB2 binds CFLAR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031216", "l": "neopullulanase activity", "d": ["Catalysis of the hydrolysis of pullulan to panose (6-alpha-D-glucosylmaltose)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22792", "l": "isonocardicin A = nocardicin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36648", "l": "2-hydroxyhexadecanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5607734", "l": "PKC-delta translocates to plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15776", "l": "ATP + dihydroxyacetone <=> ADP + dihydroxyacetone phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964773", "l": "OXGR1 binds 2OG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809707", "l": "MTMR12 binds MTMR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032781", "l": "WWTR1 (TAZ) binds TEAD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209925", "l": "DIT and MIT combine to form triiodothyronine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432946", "l": "PARVB/Affixin interacts with alpha PIX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.96", "l": "\"lactocepin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18749", "l": "[protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26375", "l": "[thioredoxin]-dithiol + prostamide H2 => [thioredoxin]-disulfide + prostamide F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388503", "l": "Oxytocin receptor bind oxytocin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41425", "l": "2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2 => formate + grixazone A + H(+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64544", "l": "acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine = 8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052735", "l": "tRNA (cytosine-3-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 3-methylcytosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5671737", "l": "p-T774-PKN1 binds CDC25C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59140", "l": "ATP + citrate + N(5)-[(S)-citryl]-D-ornithine = AMP + diphosphate + H(+) + staphyloferrin A", "d": []}, {"i": "EC:6.3.2.57", "l": "\"staphyloferrin A synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102324", "l": "2-hydroxy-6-oxo-nona-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxo-nona-2,4-dienoate + H2O = butyrate + 2-oxopent-4-enoate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853801", "l": "PSPN binds RET:GFRA4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938773", "l": "RNF144A polyubiquitinates PRKDC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29410", "l": "2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2 <=> 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350400", "l": "PK binds to DSH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-481007", "l": "Exocytosis of platelet alpha granule contents (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43361", "l": "an N-acylsphinganine + UDP-alpha-D-glucose => an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66222", "l": "asc-omegaDeltaC7-CoA + H2O2 => asc-omegaC7-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41636", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O = 1-O-(1Z-alkenyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865098", "l": "UBA6 conjugates ubiquitin to UBA6 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41122", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55400", "l": "7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) = archaeosine(15) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.113", "l": "\"alpha-1,4-glucan-protein synthase (ADP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39438", "l": "(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47148", "l": "a ubiquinone + caffeine + H2O = 1,3,7-trimethylurate + a ubiquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30374", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O <=> (-)-geosmin + acetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432067", "l": "Aquaporin-4 passively transports water out of cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30036", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 => benzene-1,2,4-triol + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0043539", "l": "protein serine/threonine kinase activator activity", "d": ["Binds to and increases the activity of a protein serine/threonine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14392", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43794", "l": "H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine => adenosine(645) in 25S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52953", "l": "lithocholate + UDP-alpha-D-glucuronate => lithocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20569", "l": "H2O + L-arginine = L-ornithine + urea", "d": []}, {"i": "EC:3.5.3.1", "l": "\"arginase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43323", "l": "1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin <=> a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13204", "l": "glycine + L-arginine <=> guanidinoacetate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67273", "l": "1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + 9-hydroxy-(10E,12Z)-octadecadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665032", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26167", "l": "AH2 + echinenone + O2 <=> 4'-hydroxyechinenone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21474", "l": "(3S)-citryl-CoA + ADP + phosphate => ATP + citrate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726580", "l": "PGR binds PGR agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56960", "l": "a ribonucleoside 5'-triphosphate + pyruvate = a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57412", "l": "AMP + diphosphate + L-tyrosinal + NADP(+) = ATP + H(+) + L-tyrosine + NADPH", "d": []}, {"i": "EC:1.2.1.101", "l": "\"L-tyrosine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694583", "l": "ABHD4 hydrolyses NAPE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866105", "l": "CCPs deglutamylate tubulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710263", "l": "GZMB cleaves GSDME (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938231", "l": "RUNX1:CBFB binds CREBBP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19148", "l": "D-glucose 6-sulfate + H2O <=> D-glucose + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482775", "l": "Release of (inferred) platelet cytosolic components (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52081", "l": "12-octadecanoyloxy-octadecanoate + H2O => 12-hydroxyoctadecanoate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030769", "l": "macrocin O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + macrocin = S-adenosyl-L-homocysteine + H+ + tylosin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21405", "l": "chloride + O2 => chlorite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32534", "l": "4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate <=> alpha-D-mannose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51433", "l": "(S)-1-aminoethylphosphonate + acetyl-CoA => [(1S)-1-acetamidoethyl]phosphonate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051744", "l": "3,8-divinyl protochlorophyllide a 8-vinyl reductase activity", "d": ["Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372697", "l": "Crk binding to p130cas (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446694", "l": "IRAK4 phosphorylates IRAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-481009", "l": "Exocytosis of platelet dense granule content (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354060", "l": "Translocation of RIAM to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23457", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => A + crepenynate + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37918", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44849", "l": "(9Z)-tetradecenoyl-CoA + (R)-carnitine => CoA + O-(9Z)-tetradecenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41358", "l": "geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH => bacteriochlorophyll a + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19650", "l": "ATP + L-aspartate + tRNA(Asp) => AMP + diphosphate + L-aspartyl-tRNA(Asp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390673", "l": "CHRM2,4 bind acetylcholine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630792", "l": "p16INK4A mutants do not bind CDK4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947499", "l": "Exchange of oxygen with sulfur in MoCo (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67913", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O => 1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12441", "l": "H2O + L-saccharopine + NAD(+) => 2-oxoglutarate + H(+) + L-lysine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25553", "l": "9alpha-copalyl diphosphate => diphosphate + stemar-13-ene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66910", "l": "9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A => acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170978", "l": "p-FRS2:CRKL binds C3G (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57331", "l": "acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] <=> CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391158", "l": "SIRP alpha binds CD47 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432164", "l": "Ca2+ influx into the post-synaptic cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37983", "l": "gamma-tocopherol = 2,3-dimethyl-6-phytylbenzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74679", "l": "UDP-beta-L-arabinofuranose(in) + UMP(out) = UDP-beta-L-arabinofuranose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021953", "l": "GAMT gene expression is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37284", "l": "H2O + L-alanyl-L-histidine => L-alanine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009973", "l": "adenylyl-sulfate reductase activity", "d": ["Catalysis of the reaction: A + AMP + 2 H+ + sulfite = adenosine 5'-phosphosulfate + AH2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4093329", "l": "EFNBs bind SDCBP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665727", "l": "FMNL2 binds CDC42:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29622", "l": "alpha-maltotetraose + beta-maltose <=> alpha-maltopentaose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35202", "l": "(S,S)-tartrate(out) <=> (S,S)-tartrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57060", "l": "2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71294", "l": "(R)-carnitine(out) + chloride(out) + 2 Na(+)(out) <=> (R)-carnitine(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22990", "l": "acetyl-CoA + CO2 + NADPH => 3-oxopropanoate + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25286", "l": "lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24135", "l": "UDP-alpha-D-galactose <=> UDP-alpha-D-galactofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005091", "l": "guanyl-nucleotide exchange factor adaptor activity", "d": ["The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15421", "l": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.3", "l": "\"long-chain-fatty-acid--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64663", "l": "a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032090", "l": "Pyrin domain binding", "d": ["Binding to a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917700", "l": "MVB Vesicle Formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0003785", "l": "actin monomer binding", "d": ["Binding to monomeric actin, also known as G-actin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45110", "l": "13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.2", "l": "\"deoxyribonuclease IV\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61118", "l": "(2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444047", "l": "Receptor FFAR3 binds carboxylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22546", "l": "a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798743", "l": "Exocytosis of secretory granule membrane proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.250759876326711", "identifiers": [{"i": "GO:0015297", "l": "antiporter activity", "d": ["Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53497", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34887", "l": "selenate(in) = selenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029992", "l": "Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013006", "l": "RHOA:GTP translocates to the ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35531", "l": "cyclo(L-phenylalanyl-L-leucyl) + 2 O2 = albonoursin + 2 H2O2", "d": []}, {"i": "EC:1.3.3.13", "l": "\"albonoursin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174097", "l": "Association of Emi1 with Cdh1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11190", "l": "L-aspartate + NH4(+) => 3-cyano-L-alanine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985104", "l": "OAS2 produces oligoadenylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1297333", "l": "Association of Acrosin Heavy and Light Chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46747", "l": "ATP + hydrogencarbonate <=> ADP + carboxyphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602458", "l": "Activation of proMMP10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73061", "l": "Ca(2+)(out) + Mn(2+)(in) => Ca(2+)(in) + Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62912", "l": "H(+) + NADH + O2 + toralactone = 1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19673", "l": "1,2,3-trihydroxybenzene + O2 = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)", "d": []}, {"i": "EC:1.13.11.35", "l": "\"pyrogallol 1,2-oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72522", "l": "2 H(+) + NADH + O2 + phenazine-1,6-dicarboxylate <=> 6-hydroxyphenazine-1-carboxylate + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9620456", "l": "sGC stimulators bind sGC:NO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61247", "l": "H2O + L-tryptophan + O2 <=> H2O2 + indole-3-pyruvate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690023", "l": "NUBPL binds 4Fe-4S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55678", "l": "(2S)-2-amino-4-deoxychorismate + H2O => chorismate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013023", "l": "RHOB GEFs activate RHOB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70596", "l": "GOT2 dimer deaminates L-Asp (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10895", "l": "(2R,3S)-3-isopropylmalate + NAD(+) <=> (2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12669", "l": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate", "d": []}, {"i": "EC:3.1.3.43", "l": "\"[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.57", "l": "\"long-chain fatty acid adenylase/transferase FadD23\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8978926", "l": "MYBL2 gene expression is inhibited by RBL1 and RBL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938176", "l": "RUNX1:CBFB binds the PF4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34912", "l": "D-methionine(in) => D-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140608", "l": "cysteine-type endopeptidase activator activity", "d": ["Binds to and increases the activity of a cysteine-type endopeptidase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944263", "l": "Association of procollagen type II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49559", "l": "H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] <=> H(+) + L-cysteinyl-[protein] + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27739", "l": "2'-deoxyguanosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944230", "l": "Association of procollagen type XVIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657642", "l": "ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binds alkylated DNA containing 1-etA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45708", "l": "3-dehydrocarnitine + acetyl-CoA = 3-dehydrocarnityl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52040", "l": "L-cystine = 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31144", "l": "(3S)-hydroxyhexanoyl-CoA + NAD(+) => 3-oxohexanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29715", "l": "2-hydroxyethane-1-sulfonate + FMNH2 + O2 = FMN + glycolaldehyde + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951486", "l": "CD46 binds C4b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44507", "l": "4-hydroxybenzoate + an all-trans-polyprenyl diphosphate <=> a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008839", "l": "BAX gene expression is stimulated by RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24224", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) = 4-methylcatechol + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44025", "l": "(3R)-3-hydroxydodecanoyl-CoA => (2E)-dodecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32223", "l": "(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35296", "l": "adenylyl-molybdopterin + H(+) + tungstate => AMP + H2O + W-molybdopterin cofactor", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24159", "l": "2-methylpropanoate + ATP <=> 2-methylpropanoyl phosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65120", "l": "H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione = L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.7", "l": "\"peroxisome-assembly ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602466", "l": "Activation of MT-MMPs by FURIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050390", "l": "valine decarboxylase activity", "d": ["Catalysis of the reaction: L-valine + H+ = 2-methylpropanamine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211219", "l": "Translocation of caspase-3 to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23783", "l": "H2O + oxaloacetate + propanoyl-CoA <=> (2S,3S)-2-methylcitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788999", "l": "HV1-mediated H+ transfer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5681980", "l": "ATG12 binds ATG7 dimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757459", "l": "ST metabolites diffuse out of ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865182", "l": "OTUD7A hydrolyses K11diUb (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21178", "l": "5-dehydro-D-gluconate + H(+) + NADPH => L-idonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25226", "l": "L-arabinitol + NAD(+) => H(+) + L-arabinose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17163", "l": "2-oxopent-4-enoate + benzoate + H(+) => 2,6-dioxo-6-phenylhexa-3-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936851", "l": "AHRR binds ARNT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844440", "l": "NLRP3 activation by elicitor proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24544", "l": "H2O + L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)", "d": []}, {"i": "EC:1.4.3.13", "l": "\"protein-lysine 6-oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429767", "l": "Passive I- efflux mediated by SMCT1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34740", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine => H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008398", "l": "sterol 14-demethylase activity", "d": ["Catalysis of the reaction: a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = a delta14 steroid + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901602", "l": "dethiobiotin binding", "d": ["Binding to dethiobiotin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444433", "l": "Cho transports from the extracellular space to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606583", "l": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26554", "l": "angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine", "d": []}, {"i": "EC:3.4.17.23", "l": "\"angiotensin-converting enzyme 2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41916", "l": "H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14075", "l": "4-amino-3-hydroxybutanoate + CO2 => 3-hydroxy-L-glutamate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641229", "l": "TLE oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947531", "l": "Molybdenum ion transfer onto molybdopterin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602466", "l": "Activation of MT-MMPs by FURIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928620", "l": "PAK1 autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55212", "l": "(2R)-hydroxyhexadecanoyl-CoA = formyl-CoA + pentadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141437", "l": "Formation of the MCC complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54404", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635102", "l": "GPR161 is internalized (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68594", "l": "(6S)-5,6,7,8-tetrahydrofolate(in) + ADP + H(+) + phosphate => (6S)-5,6,7,8-tetrahydrofolate(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33545", "l": "ergosterol + H(+) + hexadecanoate => ergosteryl palmitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46447", "l": "(11Z)-hexadecenoyl-CoA + AH2 + O2 <=> (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.247", "l": "\"codeinone reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74455", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035597", "l": "N6-isopentenyladenosine methylthiotransferase activity", "d": ["Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35270", "l": "ethanol(in) <=> ethanol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805785", "l": "AKT phosphorylates PHF20 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57888", "l": "a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.131", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74044", "l": "L-alanine(in) + L-methionine(out) => L-alanine(out) + L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163418", "l": "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10339", "l": "citrate <=> D-threo-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0015214", "l": "pyrimidine nucleoside transmembrane transporter activity", "d": ["Enables the transfer of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16466", "l": "(R)-lactate + 2 Fe(III)-[cytochrome c553] => 2 Fe(II)-[cytochrome c553] + 2 H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332236", "l": "CBL neddylates TGFBR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75621", "l": "ectocarpin C => (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004549", "l": "tRNA-specific ribonuclease activity", "d": ["Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25261", "l": "2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192925", "l": "Export of Spliced Viral mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10233", "l": "5,6-dihydrouridine 5'-monophosphate + diphosphate => 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13785", "l": "(3S)-citramalyl-CoA = H2O + itaconyl-CoA", "d": []}, {"i": "EC:4.2.1.56", "l": "\"itaconyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052814", "l": "medium-chain-aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: a medium-chain aldehyde + NAD+ = a medium-chain carboxylate + NADH + H+. Medium-chain aldehydes have a chain length of between 8 and 12 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49534", "l": "ethylene glycol + H(+) + terephthalate => 4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5604929", "l": "Activated protein C binds Protein S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27753", "l": "2'-deoxyinosine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61353", "l": "ATP + H2O + riboflavin(in) => ADP + H(+) + phosphate + riboflavin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0061778", "l": "intracellular chloride channel activity", "d": ["Enables the transmembrane transfer of chloride across the membrane of an intracellular compartment. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14285", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.137", "l": "\"sn-glycerol-3-phosphate 2-alpha-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173740", "l": "Factor B binds to C3(H2O) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21534", "l": "ADP + H(+) + phosphate + trypanothione => ATP + glutathione + glutathionylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24272", "l": "H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40016", "l": "(+)-copalyl diphosphate + H2O => 13-epi-manool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17115", "l": "H(+) + L-serine + phosphoethanolamine => H2O + L-serine-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72379", "l": "chloride(out) + iodide(in) = chloride(in) + iodide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193702", "l": "Part of the ICD migrates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50378", "l": "a ceramide(out) + ADP + H(+) + phosphate => a ceramide(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49372", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate = H2O + NAD(+) + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426032", "l": "DAG is metabolized by DAGL to 2-AG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35223", "l": "2-oxo-dADP + H2O = 2-oxo-dAMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64745", "l": "H2O + S-3-(hexan-1-ol)-L-cysteine => 3-sulfanyl-1-hexanol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-350598", "l": "Arginine<=>Agmatine+CO2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32191", "l": "H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33949", "l": "2'-N-acetylparomamine + H(+) + UDP => 2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22998", "l": "2 H2O + L-dehydroascorbate => H2O2 + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102610", "l": "(+)-secoisolariciresinol glucosyltransferase activity", "d": ["Catalysis of the reaction: (+)-secoisolariciresinol + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol monoglucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791133", "l": "Expression of Sec31A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24523", "l": "H2O + L-saccharopine + NAD(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53829", "l": "2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 => a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44018", "l": "2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH => 2,6,10,14-tetramethylpentadecanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29043", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)", "d": []}, {"i": "EC:2.1.1.148", "l": "\"thymidylate synthase (FAD)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55470", "l": "11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25105", "l": "ATP + pyridoxamine => ADP + H(+) + pyridoxamine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043724", "l": "2-keto-3-deoxygalactonate aldolase activity", "d": ["Catalysis of the reaction: 2-keto-3-deoxygalactonate = D-glyceraldehyde + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191763", "l": "snRNP:Snurportin complex formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69780", "l": "2-oxindole-3-acetate + succinyl-CoA => (2-oxoindol-3-yl)acetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46634", "l": "7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+) => 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662620", "l": "MT3 binds cadmium (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17955", "l": "(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde => 3-hydroxyanthranilate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43823", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19711", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912357", "l": "ITCH ubiquitinates DTX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182986", "l": "CBL-mediated ubiquitination of CIN85 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56022", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419426", "l": "Cannabinoid receptors can bind cannabinoids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74164", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40253", "l": "10-carboxy-13-deoxydaunorubicin + H(+) + methanol => 4-O-methylrhodomycin D + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33557", "l": "(4R)-hydroxysphinganine + a fatty acid => an N-acyl-(4R)-4-hydroxysphinganine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21174", "l": "5-dehydro-D-gluconate + H(+) + NADH => L-idonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112342", "l": "Inactivation of MAP2K1 by CDK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165195", "l": "GTP loading by Rheb (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788628", "l": "p-Y-STATs dissociate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14566", "l": "(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52529", "l": "2-oxoglutarate + L-asparagine => 2-oxosuccinamate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140482", "l": "iron sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of iron."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917700", "l": "MVB Vesicle Formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60197", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372724", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57395", "l": "(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine <=> 3-O-acetyl-4'-O-demethylpapaveroxine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419279", "l": "Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17837", "l": "2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate", "d": []}, {"i": "EC:3.1.3.63", "l": "\"2-carboxy-D-arabinitol-1-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033957", "l": "lambda-carrageenase activity", "d": ["Catalysis of the endohydrolysis of beta-1,4-linkages in the backbone of lambda-carrageenan, resulting in the tetrasaccharide alpha-D-Galp2,6S2-(1->3)-beta-D-Galp2S-(1->4)-alpha-D-Galp2,6S2-(1->3)-D-Galp2S."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047810", "l": "D-alanine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: D-alanine + 2-oxoglutarate = pyruvate + D-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205319", "l": "Interaction of APS and p-KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437118", "l": "GPVI stimulates PI3K beta, gamma (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20312", "l": "2 H2O2 <=> 2 H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34050", "l": "6'''-deamino-6'''-hydroxyneomycin C + O2 <=> 6'''-deamino-6'''-oxoneomycin C + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114544", "l": "p115-RhoGEF activation of RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875374", "l": "MET binds LRIG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38610", "l": "2'-phospho-cyclic ADP-ribose + nicotinate <=> nicotinate-adenine dinucleotide phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71541", "l": "H(+)(in) + 2 nitrate(in) => H(+)(out) + 2 nitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11196", "l": "5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate", "d": []}, {"i": "EC:2.4.2.21", "l": "\"nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32417", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADH => (1S,2S,4R)-isodihydrocarveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26418", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 = (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417908", "l": "P2RY1 binds ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26320", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate <=> 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936381", "l": "OTUD5 deubiquitinates TRAF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50218", "l": "(8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38606", "l": "NADP(+) <=> 2'-phospho-cyclic ADP-ribose + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.8", "l": "\"muramoylpentapeptide carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34362", "l": "a 1,2-diacylglycerol + H2O <=> a 2-acylglycerol + a carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11735", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B <=> H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168930", "l": "Viral dsRNA:TLR3:TRIF complex recruits RIP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018746", "l": "RHOQ binds effectors at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018682", "l": "atrazine N-dealkylase activity", "d": ["Catalysis of the reaction: atrazine + O2 + 2 H+ = deethylatrazine + acetaldehyde + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22994", "l": "acetyl-CoA + CO2 + NADH => 3-oxopropanoate + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39260", "l": "(3R)-hydroxy-(13Z)-docosenoyl-CoA => (2E,13Z)-docosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863727", "l": "STON2 is neddylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46875", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA <=> a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24837", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56237", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008513", "l": "secondary active organic cation transmembrane transporter activity", "d": ["Enables the transfer of organic cations from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction."]}, {"i": "REACT:R-HSA-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73321", "l": "cimicifugate K + CoA => (2R,3S)-piscidate + (E)-4-coumaroyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664278", "l": "Phosphorylation and activation of PLCG due to FCGR3A effect (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28123", "l": "ATP + di-trans,octa-cis-undecaprenol => ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70655", "l": "H(+)(in) + sarcosine(in) = H(+)(out) + sarcosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9650473", "l": "SERPING1 is secreted (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31515", "l": "4'-apo-beta-carotenal + H2O + NAD(+) = 2 H(+) + NADH + neurosporaxanthin", "d": []}, {"i": "EC:1.2.1.82", "l": "\"beta-apo-4'-carotenal oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8934742", "l": "RUNX1 binds PRMT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694524", "l": "nsp13 binds nsp12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980051", "l": "DLL4 binds NOTCH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.706056554619465", "identifiers": [{"i": "GO:0140030", "l": "modification-dependent protein binding", "d": ["Binding to a protein upon post-translation modification of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15717", "l": "daunorubicin + H(+) + NADPH + O2 = doxorubicin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14821", "l": "beta-L-arabinopyranose = L-ribulose", "d": []}, {"i": "EC:5.3.1.4", "l": "\"L-arabinose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862084", "l": "PILRA,PILRB bind CD99 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032093", "l": "SAM domain binding", "d": ["Binding to a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61103", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950674", "l": "IL27 translocates from the cytosol to the extracellular space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702623", "l": "sorafenib-resistant FLT3 mutants don't bind sorafenib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43182", "l": "5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432897", "l": "ILK interacts with beta-1 integrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11507", "l": "6-demethylsterigmatocystin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + sterigmatocystin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54837", "l": "H(+) + heptan-2-one + NADPH + O2 => H2O + NADP(+) + pentyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627369", "l": "SEPT4 binds XIAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66730", "l": "ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate => ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770063", "l": "S1,S2 Dissociate from S1:ACE2:S2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050087", "l": "mannitol dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: 2 [Fe(III)cytochrome c] + D-mannitol = 2 [Fe(II)cytochrome c] + D-fructose + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63563", "l": "angiotensin I + H2O <=> angiotensin II + L-histidyl-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58254", "l": "ADP-D-ribose + L-asparaginyl-[protein] => H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1470009", "l": "Phosphorylation of STATs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74596", "l": "(2S,3R)-3-methyl-L-aspartate => mesaconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050047", "l": "leucine 2,3-aminomutase activity", "d": ["Catalysis of the reaction: L-leucine = (3R)-beta-leucine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052724", "l": "inositol hexakisphosphate 3-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159773", "l": "Furin cleaves pro-protein S to protein S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66542", "l": "AH2 + cholesta-5,7-dien-3beta,25-diol => 7-dehydrocholesterol + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2995330", "l": "COX10 transforms heme to heme O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11788", "l": "H2O + L-aspartate + NAD(+) = H(+) + NADH + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44177", "l": "a 2,3-diacyl-sn-glycerol + H2O => 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49027", "l": "L-tryptophan + O2 <=> 2-iminio-3-(indol-3-yl)propanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16796", "l": "H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine <=> (R)-4'-phosphopantetheine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51960", "l": "(Z)-2-methylpropanal oxime = 2-methylpropanenitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74258", "l": "XDH oxidizes xanthine to form urate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008899", "l": "homoserine O-succinyltransferase activity", "d": ["Catalysis of the reaction: L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21560", "l": "3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol = 1,4-dithiothreitol + 2,3-epoxyphylloquinone", "d": []}, {"i": "EC:1.17.4.5", "l": "\"vitamin-K-epoxide reductase (warfarin-insensitive)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46042", "l": "ADP + dCMP + H(+) => 2'-deoxycytidine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202731", "l": "JAM3 dimerises (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24466", "l": "D-glyceraldehyde 3-phosphate + pyruvate => 2-dehydro-3-deoxy-6-phospho-D-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0015141", "l": "succinate transmembrane transporter activity", "d": ["Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021596", "l": "Membrane estrogen receptors bind SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110360", "l": "Recruitment of POLB to the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65885", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine => H2O + L-glutamate + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205132", "l": "NRAGE activates JNK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750226", "l": "NLRC5 binds IKBKB and CHUK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37942", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52136", "l": "a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+)", "d": []}, {"i": "EC:3.6.1.70", "l": "\"guaosine-5'-diphospho-5'-[DNA] diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050335", "l": "thiocyanate isomerase activity", "d": ["Catalysis of the reaction: benzyl isothiocyanate = benzyl thiocyanate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11179", "l": "kojibiose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61316", "l": "germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382057", "l": "Release of novel PDGFs as latent factors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047651", "l": "alkylhalidase activity", "d": ["Catalysis of the reaction: bromochloromethane + H2O = bromide + chloride + formaldehyde + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390649", "l": "CHRM1,3,5 bind acetylcholine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27698", "l": "GDP-beta-L-galactose + phosphate = beta-L-galactose 1-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70101", "l": "penilactone A => H(+) + o-quinone methide + peniphenone D", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022859", "l": "dephosphorylation-gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel that opens in response to dephosphorylation of one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022141", "l": "Prolysyl oxidase activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654515", "l": "KAL1 binds HS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21300", "l": "H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.8", "l": "\"cerebroside-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034597", "l": "phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31671", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.235", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69041", "l": "(2S)-2-nitrosobutanedioate + H(+) + NADPH + O2 => 2-nitrobutanedioate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40797", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928627", "l": "EPHB phosphorylates TIAM1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114553", "l": "Activation of conventional Protein Kinase C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58545", "l": "2 L-ascorbate + N-tetradecanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60193", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797554", "l": "ABP1 binds SHANK proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983153", "l": "E1 mediated ubiquitin activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392834", "l": "Activation of EPACs by cAMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4332363", "l": "Autophosphorylation and activation of CAMK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83677", "l": "C4 deamination of cytidine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12343", "l": "L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] <=> H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170159", "l": "Translocation of Cdc25 to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49579", "l": "AH2 + GTP + S-adenosyl-L-methionine <=> (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675656", "l": "EDA:EDAR binds EDARADD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17593", "l": "3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine", "d": []}, {"i": "EC:2.6.1.64", "l": "\"glutamine--phenylpyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20409", "l": "alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN", "d": []}, {"i": "EC:2.7.1.42", "l": "\"riboflavin phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75835", "l": "(5S)-hydroperoxy-(6E,8Z)-octadecadienoate + 2 glutathione = (5S)-hydroxy-(6E,8Z)-octadecadienoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73596", "l": "dCMP + H2O => dUMP + NH4+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57892", "l": "a quinone + 5 H(+)(in) + NADPH = a quinol + 4 H(+)(out) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388831", "l": "Phosphorylation of CD28 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45414", "l": "glycerol + H(+) + prostaglandin D2 => H2O + prostaglandin D2-1-glycerol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59732", "l": "biotinyl-5'-AMP + L-lysyl-[protein] = AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800001", "l": "TP53 family members stimulate FAS gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47029", "l": "[DsrC protein]-S-sulfo-L-cysteine/L-cysteine => [DsrC protein]-disulfide + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202443", "l": "Oligomerization of CARMA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948034", "l": "FGR binds LDL:LRP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578777", "l": "DMPK phosphorylates PLN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28102", "l": "GDP-alpha-D-mannose + H2O = D-mannose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73094", "l": "AMP(out) + FMN(in) <=> AMP(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868118", "l": "MAPK12 phosphorylates PTPN3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25248", "l": "(R)-S-lactoylglutathione + H2O <=> (R)-lactate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9706837", "l": "AR binds AR antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156930", "l": "GTP-binding activates eEF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19874", "l": "dehydroepiandrosterone 3-sulfate + H2O => 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879459", "l": "F-actin capping protein is a heterodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43580", "l": "A + D-arginine = AH2 + iminoarginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875523", "l": "MET binds TNS3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47388", "l": "a tetradecanoate ester + H2O = an aliphatic alcohol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55064", "l": "4-methylpentanoyl-CoA + H2O = 4-methylpentanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420121", "l": "SFKs phosphorylate PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53876", "l": "a cytidine in tRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433488", "l": "Phosphorylation of SHP2 by SFKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55879", "l": "apo-[aequorin] + coelenterazine <=> apo-[aequorin]--coelenterazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731262", "l": "nsp6 localizes to the nuclear envelope (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051507", "l": "beta-sitosterol UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a beta-sitosterol = UDP + O-glucosyl-beta-sitosterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71439", "l": "L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0050997", "l": "quaternary ammonium group binding", "d": ["Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27687", "l": "ATP + GDP => ADP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58481", "l": "a cytidine in mRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044105", "l": "L-xylulose reductase (NAD+) activity", "d": ["Catalysis of the reaction: xylitol + NAD+ = L-xylulose + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197963", "l": "DHFR2 reduces FOLA to DHF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11696", "l": "3'-demethylstaurosporine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + staurosporine", "d": []}, {"i": "EC:2.1.1.139", "l": "\"3'-demethylstaurosporine O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0070854", "l": "myosin VI heavy chain binding", "d": ["Binding to a heavy chain of a myosin VI complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420724", "l": "CASR binds Ca2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607745", "l": "1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62326", "l": "(+)-malbrancheamide + FADH2 => (+)-malbrancheamide B + chloride + FAD + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52331", "l": "L-arginine + O2 + reduced [flavodoxin] <=> H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21927", "l": "3-dehydro-L-gulonate + NAD(+) <=> 2,3-dioxo-L-gulonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55703", "l": "an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O <=> an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53533", "l": "(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2197690", "l": "Detachment of WASP/WAVE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933537", "l": "Recruitment of TANK to TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871227", "l": "RET binds GFRA4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42661", "l": "NAD(+) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45148", "l": "3-(methylsulfanyl)acryloyl-CoA + H2O = 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:1990782", "l": "protein tyrosine kinase binding", "d": ["Binding to protein tyrosine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15585", "l": "15-cis-phytoene + 4 A = 4 AH2 + all-trans-lycopene", "d": []}, {"i": "EC:1.3.99.31", "l": "\"phytoene desaturase (lycopene-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31940", "l": "2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] => DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390846", "l": "D2D3,4 bind to DA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62195", "l": "O2 + peregrinol + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592229", "l": "TFAM translocates from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45902", "l": "a 4-saturated (2E)-enoyl-CoA => a (3Z)-enoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046875", "l": "ephrin receptor binding", "d": ["Binding to an ephrin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56000", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35792", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine => H(+) + kanamycin X + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019145", "l": "aminobutyraldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034737", "l": "ergosterol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + ergosterol = CoA + ergosterol ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42912", "l": "cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.191", "l": "\"23S rRNA (cytosine(1962)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140563", "l": "UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity", "d": ["Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018557", "l": "1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxyfluorene + O2 = 2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873927", "l": "Release of STAT1 dimer from active receptor unit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9669893", "l": "KIT binds type I TKIs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139917", "l": "tBID activates BAX protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11506", "l": "H(+) + S-adenosyl-L-homocysteine + sterigmatocystin => 6-demethylsterigmatocystin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0061593", "l": "sulfoquinovose isomerase activity", "d": ["Catalysis of the reaction sulfoquinovose = 6-deoxy-6-sulfofructose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35846", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977371", "l": "Factor I inactivates Factor H-boundC3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61428", "l": "cis-trans-nepetalactol + NAD(+) = cis-trans-nepetalactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685519", "l": "Polyadenylation of SARS-CoV-1 genomic RNA (plus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112604", "l": "Phosphorylated STATs are released (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45725", "l": "(E)-4-coumaroyl alcohol + NADP(+) => (E)-4-coumaraldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63867", "l": "O2 + octadecanoate <=> (2R)-2-hydroperoxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48466", "l": "ganglioside GA1 + N-acetylneuraminate => ganglioside GM1b + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942302", "l": "MMP13 cleaves OPTC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757256", "l": "MCM3 binds MCM5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635859", "l": "GLI:SUFU dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022880", "l": "protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22358", "l": "CO2 + phosphate + phosphoenolpyruvate => diphosphate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66657", "l": "Cu(2+)(out) + L-ascorbate(in) => Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009022", "l": "tRNA nucleotidyltransferase activity", "d": ["Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49721", "l": "2 H(+) + NADH + 2 O2 + protoviolaceinate => CO2 + 2 H2O + NAD(+) + violacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705959", "l": "SARS-CoV-1 6 binds KPNA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014449", "l": "RHOG binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20537", "l": "H2O + holo-[ACP] = (R)-4'-phosphopantetheine + apo-[ACP] + H(+)", "d": []}, {"i": "EC:3.1.4.14", "l": "\"[acyl-carrier-protein] phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49654", "l": "H2O + NAD(+) + violaceinate => H(+) + NADH + O2 + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74295", "l": "n H(+)(out) + serotonin(in) = n H(+)(in) + serotonin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61454", "l": "11a-hydroxy-oxytetracycline + H2O + NADP(+) => H(+) + NADPH + O2 + oxytetracycline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68698", "l": "17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 17beta-estradiol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74992", "l": "deoxyerythrostominone(in) => deoxyerythrostominone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719375", "l": "Defective DPM2 does not transfer mannose to DOLP to form DOLPman (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449117", "l": "TXLNA (IL14) binds syntaxin1A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63693", "l": "alcohol glucuronate acceptor + UDP-alpha-D-glucuronate => a beta-D-glucuronoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848776", "l": "PTK6 phosphorylates DOK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362427", "l": "Hh-Np binds GPC5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74184", "l": "S-adenosyl-L-methionine + taxifolin => H(+) + S-adenosyl-L-homocysteine + taxifolin 4'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48024", "l": "1,2,3-tripropanoylglycerol + H2O = dipropanoylglycerol + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72132", "l": "agmatine(out) => agmatine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43360", "l": "an N-acylsphinganine + UDP-alpha-D-glucose = an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71081", "l": "cordypyrone B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cordypyrone A + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850534", "l": "PDCL promotes G-protein beta 5 folding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16037", "l": "phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35741", "l": "4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone => cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30135", "l": "dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34375", "l": "4-guanidinobutanamide + H2O = 4-guanidinobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610732", "l": "GSK3 phosphorylates p-GLI3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189406", "l": "4 PBGs bind to form HMB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.99", "l": "\"4-(gamma-glutamylamino)butanal dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696131", "l": "AOC1 deaminates Hist (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205321", "l": "Interaction of KIT and sSCF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174255", "l": "Degradation multiubiquitinated Cyclin A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350186", "l": "CUBN binds GC:25(OH)D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53435", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1671687", "l": "PRLR activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8878654", "l": "ACP6 hydrolyses MYS-LPA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32081", "l": "(13E)-labda-7,13-dien-15-ol + diphosphate => (13E)-labda-7,13-dien-15-yl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68611", "l": "Formation of ORC(1-5) complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696323", "l": "CNRs bind CNR agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48360", "l": "a 1,2-saturated fatty acid + H2O2 = a 2-hydroxy fatty acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.825956045430587", "identifiers": [{"i": "GO:0005248", "l": "voltage-gated sodium channel activity", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}, {"i": "REACT:R-HSA-5576895", "l": "SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67900", "l": "glutarate + succinyl-CoA = glutaryl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40291", "l": "ATP + CoA + tetradecanedioate = AMP + diphosphate + tetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210289", "l": "Recruitment of SYK to p-DAP12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30242", "l": "n a quinone + n H(+) + n hydrogen sulfide <=> n a quinol + n sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37005", "l": "3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA => (11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38929", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205321", "l": "Interaction of KIT and sSCF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62287", "l": "2 ATP + L-proline + L-tryptophan + NADPH <=> (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-381087", "l": "Dimerization of PERK (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10982", "l": "D-serine => L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103088", "l": "2-(6'-methylthio)hexylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxo-8-methylthiooctanoate + acetyl-CoA + H2O <=> H+ + 2-(6'-methylthio)hexylmalate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454916", "l": "The ABCC family mediates organic anion transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034005", "l": "germacrene-A synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43574", "l": "5-guanidino-2-oxopentanoate + AH2 + NH4(+) => A + D-arginine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56222", "l": "3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750226", "l": "NLRC5 binds IKBKB and CHUK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39192", "l": "(2E)-docosenoyl-CoA + H(+) + NADPH => docosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60816", "l": "2-oxoglutarate + gibberellin A14 aldehyde + O2 = CO2 + gibberellin A14 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63890", "l": "CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine => hexadecanoyl-CoA + sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683455", "l": "nsp16 binds VHL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769383", "l": "CBY1 binds beta-catenin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937097", "l": "MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17182", "l": "a long-chain fatty aldehyde + FMNH2 + O2 => a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20352", "l": "H(+) + NADH + O2 + toluene <=> 2-hydroxytoluene + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57927", "l": "H2O + mutildienyl diphosphate <=> diphosphate + premutilin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61068", "l": "acetyl-CoA + horhammericine = 19-O-acetylhorhammericine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27291", "l": "A + formate + H(+) => AH2 + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19667", "l": "6-carboxyhex-2-enoyl-CoA + H(+) + NADH => 6-carboxyhexanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8873850", "l": "STARD5 binds DCA, LCA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874849", "l": "CREBRF binds CREB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8963851", "l": "VD3 dissociates from GC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23944", "l": "(E)-coniferol + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-coniferol + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.111", "l": "\"coniferyl-alcohol glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849055", "l": "PTK6 binds ARHGAP35 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016633", "l": "galactonolactone dehydrogenase activity", "d": ["Catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75310", "l": "D-serine(in) + L-glutamine(out) + Na(+)(out) <=> D-serine(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72115", "l": "glycine betaine(out) + Na(+)(out) = glycine betaine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50333", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60773", "l": "2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2 => 3 CO2 + gibberellin A9 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196753", "l": "2xPPCS ligates PPanK with Cys (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102294", "l": "cholesterol dehydrogenase activity", "d": ["Catalysis of the reaction: cholesterol + NAD = cholest-5-en-3-one + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008967", "l": "phosphoglycolate phosphatase activity", "d": ["Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11780", "l": "3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.134", "l": "\"galactosylxylosylprotein 3-beta-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8979082", "l": "Phosphorylated ETS2 binds p16INK4A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69872", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] => (22S)-22-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22180", "l": "(S)-norreticuline + S-adenosyl-L-methionine = (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103104", "l": "6-methylthiohexyldesulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 6-methylthiohexyldesulfoglucosinolate + 3'-phosphonato-5'-adenylyl sulfate <=> adenosine 3',5'-bismonophosphate + H+ + 6-methylthiohexylglucosinolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74726", "l": "Dissociation of insulin from insulin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61106", "l": "(2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789524", "l": "Expression of IL4,IL13-downregulated extracellular genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75799", "l": "Na(+)(out) + pyruvate(out) = Na(+)(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65414", "l": "dAMP(out) + NAD(+)(in) => dAMP(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-481044", "l": "Surface deployment of platelet alpha granule membrane components (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68077", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP => a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39525", "l": "(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62674", "l": "an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine => a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37519", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419011", "l": "Transhomodimerization of Nectins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20319", "l": "1-pyrroline-2-carboxylate + H(+) + NADPH => L-proline + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3229181", "l": "CALM1:Ca2+ binds CNG channel (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176452", "l": "Degradation of ubiquitinated SMAD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74282", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IVA <=> a 2-acyl-sn-glycero-3-phosphocholine + a lipid IVB", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070204", "l": "2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + H+ + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610720", "l": "PKA phosphorylates GLI3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67455", "l": "a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O <=> 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70184", "l": "2 alpha-isomaltosyl-(1->4)-D-maltotriose => alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981892", "l": "Active G alpha (z) binds RGS proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228578", "l": "tetX LC cleaves target cell VAMP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679028", "l": "JAK3 binds JAK3 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0016752", "l": "sinapoyltransferase activity", "d": ["Catalysis of the transfer of a sinapoyl group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0008172", "l": "S-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5686430", "l": "MUS81 binds EME1, EME2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624133", "l": "ARL3:GTP binds the UNC119B complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.25.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35853", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24772", "l": "7(1)-hydroxychlorophyllide a + NADP(+) = chlorophyllide b + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31615", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine = dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.236", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850777", "l": "SPINK6 binds KLK14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32382", "l": "(1R,2R,4S)-limonene-1,2-diol + NAD(+) <=> (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010471", "l": "GDP-galactose:mannose-1-phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: GDP-beta-L-galactose + alpha-D-mannose 1-phosphate = GDP-alpha-D-mannose + beta-L-galactose-1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21690", "l": "an oxidized polyvinyl alcohol + n H2O2 => a polyvinyl alcohol + n O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168326", "l": "Assembly of an Active Transcription Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49174", "l": "12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48406", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein] => apo-[aryl-carrier protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34248", "l": "1-deoxymethyl-sphinganine + NADP(+) => 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141316", "l": "TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17486", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26363", "l": "2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+) => L-tyrosine + NADPH + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58783", "l": "a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine <=> a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-994148", "l": "LRRC16A binds F-actin capping protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35190", "l": "(Z)-3-aminoperacrylic acid + AH2 <=> (Z)-3-aminoacrylate + A + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47770", "l": "2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9650858", "l": "Meglitinides bind ABCC8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047983", "l": "homoglutathione synthase activity", "d": ["Catalysis of the reaction: beta-alanine + L-gamma-glutamyl-L-cysteine + ATP = gamma-L-glutamyl-L-cysteinyl-beta-alanine + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41617", "l": "D-ribose 2,5-bisphosphate + H2O => D-ribose 5-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667456", "l": "AVPR1A,B bind desmopressin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082369", "l": "Acetylated HSF1 dissociates from DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429815", "l": "Formation Of Bloc-1 Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35153", "l": "(3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH => 4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35421", "l": "an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP => an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803719", "l": "TP53 binds ZNF385A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664867", "l": "NBR1 binds MAP1LC3B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216043", "l": "Collagen type II binds integrin alpha10beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48516", "l": "1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57677", "l": "4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase] => 4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10991", "l": "H2O + nitrous oxide <=> 2 e(-) + 2 H(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950782", "l": "p-STAT1 binds p-STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50432", "l": "AH2 + prostaglandin G1 = A + H2O + prostaglandin H1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047595", "l": "6-hydroxynicotinate reductase activity", "d": ["Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32664", "l": "5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine => 5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56806", "l": "2 cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein] => 2 cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047909", "l": "galactolipid O-acyltransferase activity", "d": ["Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = acylmono-beta-D-galactosyl-diacylglycerol + mono-beta-D-galactosylacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58872", "l": "24-methylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339711", "l": "misspliced mutants of LRP5 support enhanced beta-catenin-dependent signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047223", "l": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12882", "l": "ADP-alpha-D-glucose + sn-glycerol 3-phosphate => 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66507", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614810", "l": "Activation of Latent HCMV Genome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63719", "l": "losartan + UDP-alpha-D-glucuronate <=> losartan-1-N-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0019958", "l": "C-X-C chemokine binding", "d": ["Binding to a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29773", "l": "ADP + arsenate(out) + H(+) + phosphate => arsenate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65025", "l": "7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+) => dehydrocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700175", "l": "Active ALK phosphorylates SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73747", "l": "(R)-noradrenaline(in) + 2 H(+)(out) = (R)-noradrenaline(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905773", "l": "8-hydroxy-2'-deoxyguanosine DNA binding", "d": ["Binding to 8-hydroxy-2'-deoxyguanosine an oxidized purine residue found in damaged DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426147", "l": "SREBP1A,1C,2 binds the FDPS promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24769", "l": "7(1)-hydroxychlorophyllide a + NAD(+) => chlorophyllide b + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34621", "l": "1-deoxy-11beta-hydroxypentalenate + CO2 + succinate => 1-deoxypentalenate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17241", "l": "an alpha-amino acid ester + H2O = an alcohol + an alpha-amino acid + H(+)", "d": []}, {"i": "EC:3.1.1.43", "l": "\"alpha-amino-acid esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44917", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH => (3E)-decenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193665", "l": "MYD88 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692880", "l": "HRH3 binds Hist (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63801", "l": "GDP-alpha-D-mannose => GDP-beta-L-gulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56491", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665404", "l": "RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9626817", "l": "PKC phosphorylates NCF1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702510", "l": "FLT mutants bind type II TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389381", "l": "Gads binds CD28 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.47", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16913", "l": "a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.8", "l": "\"CDP-diacylglycerol--serine O-phosphatidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36423", "l": "2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49902", "l": "H2O2 + phenazine-1,6-dicarboxylate => 5,10-dihydrophenazine-1,6-dicarboxylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27923", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 => 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69431", "l": "arsenite + 3 glutathione + H(+) <=> arsenic triglutathione + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60983", "l": "12-hydroxydodecanoate + NAD(+) <=> 12-oxododecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37177", "l": "1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853801", "l": "PSPN binds RET:GFRA4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675947", "l": "TNFSF18 binds TNFRSF18 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17286", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004082", "l": "bisphosphoglycerate mutase activity", "d": ["Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170149", "l": "Translocation of active Cdc25C to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21722", "l": "H2O + hydrogen cyanide => formamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76416", "l": "Benzene is hydroxylated to phenol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33786", "l": "1(F)-beta-D-fructosylsucrose + sucrose <=> 1,6-kestotetraose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29438", "l": "enterobactin(in) + H(+)(out) <=> enterobactin(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17931", "l": "ADP + an N-acylsphing-4-enine 1-phosphate + H(+) => an N-acylsphing-4-enine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67090", "l": "ADP + H(+) + phosphate + tetracosanoate(out) => ATP + H2O + tetracosanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627089", "l": "CASP9 is phosphorylated at T412 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42526", "l": "pseudouridine(1911/1915/1917) in 23S rRNA => uridine(1911/1915/1917) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21383", "l": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA <=> AMP + diphosphate + phytanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65343", "l": "acetyl-CoA + L-threonyl-[protein] <=> CoA + O-acetyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140950", "l": "histone H2A deubiquitinase activity", "d": ["A histone deubiquitinase that cleaves ubiquitin from a histone H2A protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39188", "l": "(3R)-hydroxydocosanoyl-CoA => (2E)-docosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53328", "l": "H2O + UDP-2,3-diacyl-alpha-D-glucosamine = 2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48956", "l": "[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56822", "l": "A + cyclooctat-9-ene-5,7-diol + H2O => AH2 + cyclooctat-9-en-7-ol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29363", "l": "dCMP + H2O = 2'-deoxycytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362522", "l": "ALDHs oxidise atRAL to atRA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74794", "l": "(R)-salsolinol(in) <=> (R)-salsolinol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65648", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine = a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875817", "l": "MET phosphorylates STAT3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798749", "l": "Exocytosis of specific granule lumen proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28462", "l": "pyridoxal(in) = pyridoxal(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50172", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672817", "l": "Active MTORC1 binds the ULK1 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102805", "l": "codeine O-demethylase activity", "d": ["Catalysis of the reaction: codeine + 2-oxoglutarate + O2 <=> morphine + formaldehyde + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43685", "l": "ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate => AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17040", "l": "indole-3-ethanol + NADP(+) <=> H(+) + indole-3-acetaldehyde + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018857", "l": "2,4-dichlorobenzoate-CoA ligase activity", "d": ["Catalysis of the reaction: 2,4-dichlorobenzoate + ATP + CoASH = AMP + diphosphate + 2,4-dichlorobenzoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57195", "l": "H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] <=> glycolate + H(+) + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3451147", "l": "KAT5 HAT complex acetylates TCF4 gene at histone H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975115", "l": "IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42148", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1253343", "l": "WWOX binds ERBB4s80 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73945", "l": "FAS-mediated dimerization of procaspase-8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981832", "l": "NMUR2 binds neuromedin-S (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30892", "l": "O-acetyl-L-serine + thiosulfate => acetate + H(+) + S-sulfo-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13469", "l": "A + H2O + thymine = 5-methylbarbiturate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21232", "l": "L-histidine = NH4(+) + trans-urocanate", "d": []}, {"i": "EC:4.3.1.3", "l": "\"histidine ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866277", "l": "AP-2 directly binds some endocytic cargo (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49416", "l": "ADP + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + AMP + H(+)", "d": []}, {"i": "EC:2.7.1.212", "l": "\"alpha-D-ribose-1-phosphate 5-kinase (ADP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29935", "l": "cytosine(in) + H(+)(in) = cytosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21443", "l": "a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 <=> a long-chain alkane + formate + H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473584", "l": "Collagen type III degradation by MMP15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56636", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201630", "l": "Caspase-mediated cleavage of Acinus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791327", "l": "TP53 binds the BCL2L14 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27726", "l": "5-dehydro-4-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31203", "l": "acetyl-CoA + hexanoyl-CoA = 3-oxooctanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60112", "l": "(R)-3-(indol-3-yl)lactoyl-CoA = (E)-3-(indol-3-yl)acryloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25829", "l": "AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2 => A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236949", "l": "Translocation of antigenic peptides back to phagosomes via TAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950782", "l": "p-STAT1 binds p-STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265968", "l": "Association of RAD51 with BRCA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28847", "l": "Li(+)(in) + melibiose(in) = Li(+)(out) + melibiose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621615", "l": "CD209 binds ICAM3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42734", "l": "N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(527) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38027", "l": "(E)-caffeate + hydrocaffeoyl-CoA = (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate", "d": []}, {"i": "EC:2.8.3.23", "l": "\"caffeate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63147", "l": "H2O + N-(15Z-tetracosenoyl)-ethanolamine <=> (15Z)-tetracosenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74348", "l": "O-acyl-(R)-carnitine(in) => O-acyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981610", "l": "Neuroglobin binds oxygen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43530", "l": "2-aminomalonate semialdehyde + H(+) + NADH => L-serine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674018", "l": "BRAP binds RAS:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62938", "l": "2'-deoxycytidine + acetate + H(+) => H2O + N(4)-acetyl-2'-deoxycytidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.18", "l": "\"cytosol non-specific dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34005", "l": "7-dehydrodesmosterol + 2 H2O + NADP(+) => 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44213", "l": "3-hydroxytetradecanoate + ATP + CoA => 3-hydroxytetradecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377644", "l": "Release of CSK from SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71928", "l": "2 Na(+)(out) + tauroursodeoxycholate(out) => 2 Na(+)(in) + tauroursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875451", "l": "MET phosphorylates CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17512", "l": "H2O + thiamine <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696670", "l": "CHD1L is recruited to GG-NER site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74287", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA = an acyl-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36608", "l": "2-oxoglutarate + L-arginine + O2 => (2S,3S)-hydroxyarginine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69567", "l": "12 ATP + L-asparagine + L-aspartate + L-cysteine + L-glutamate + L-histidine + 3 L-isoleucine + L-leucine + L-lysine + L-ornithine + L-phenylalanine <=> 12 AMP + bacitracin A + 12 diphosphate + 12 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21106", "l": "25-hydroxycholesterol + A + H2O => AH2 + cholesterol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0003937", "l": "IMP cyclohydrolase activity", "d": ["Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114264", "l": "Translocation of activated BAX to the mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59222", "l": "(2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+) => (2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2426569", "l": "Interaction of DAP12 and IREM2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938174", "l": "PF4 gene transcription is stimulated by RUNX1:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50438", "l": "prostaglandin E1 => prostaglandin H1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028724", "l": "AMOT proteins bind YAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018802", "l": "2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity", "d": ["Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174124", "l": "Dephosphorylation of phospho-Cdh1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60764", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone = cinerin II + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51845", "l": "(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029521", "l": "NR1H2,3 binds the ABCG5 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14483", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate => 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40983", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = (9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62568", "l": "H2O + S-benzyl-L-cysteinylglycine = glycine + S-benzyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018807", "l": "RAC3 GDIs block activation of RAC3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11185", "l": "3-(carbamoylamino)propanoate + 2 H(+) + H2O => beta-alanine + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36639", "l": "3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine = 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.294", "l": "\"3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55608", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392749", "l": "Transport of L1 into endosomes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018774", "l": "RHOBTB1 binds GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40830", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43889", "l": "[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine => [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110172", "l": "MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10198", "l": "2-succinylbenzoate + H2O => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008913", "l": "lauroyltransferase activity", "d": ["Catalysis of the transfer of a lauroyl (dodecanoyl) group from one compound to another."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37769", "l": "1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36530", "l": "(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA <=> (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754180", "l": "APAP translocates from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617182", "l": "PRKACA phosphorylates PLN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23655", "l": "N-terminal L-glutaminyl-[peptide] <=> N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74077", "l": "NAD(+) + phylloquinol => H(+) + NADH + phylloquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72967", "l": "4-methyl-2-oxopentanoate(out) + 2 Na(+)(out) = 4-methyl-2-oxopentanoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25734", "l": "H(+) + N,N-dihydroxy-L-tetrahomomethionine <=> (E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762343", "l": "PREDL:ALB dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21226", "l": "CMP + H(+) + sphing-4-enine-phosphocholine => CDP-choline + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31047", "l": "(S)-methylmalonate semialdehyde + CoA + NAD(+) = CO2 + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.97", "l": "\"3-sulfolactaldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23296", "l": "aceneuramate = N-acetyl-D-mannosamine + pyruvate", "d": []}, {"i": "EC:4.1.3.3", "l": "\"N-acetylneuraminate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34027", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) = (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39494", "l": "(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693761", "l": "FA2H hydroxylates CERA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0015204", "l": "urea transmembrane transporter activity", "d": ["Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20685", "l": "galactitol + NAD(+) = H(+) + keto-D-tagatose + NADH", "d": []}, {"i": "EC:1.1.1.16", "l": "\"galactitol 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804741", "l": "MDM2 forms homo- or heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22066", "l": "ergosterol + H2O => 5alpha-ergosta-7,22-diene-3beta,5-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58625", "l": "N-dodecanoyl-(2S)-hydroxyglycine => dodecanamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68954", "l": "Mcm2-7 is phosphorylated by DDK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26535", "l": "3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1067640", "l": "IL6 binds IL6R-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222341", "l": "H2O2 gets scavenged by unsaturated lipid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23564", "l": "2 columbamine + O2 = 2 berberine + 2 H2O", "d": []}, {"i": "EC:1.21.3.2", "l": "\"columbamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15439", "l": "a long-chain fatty acyl-CoA + H(+) + NADPH => a long-chain fatty aldehyde + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009488", "l": "IL34 binds CSF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1008220", "l": "Expression of globin genes under control of the beta globin control region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65519", "l": "5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O <=> NH4(+) + pre-mycofactocin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40652", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13786", "l": "(3S)-citramalyl-CoA => H2O + itaconyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67406", "l": "carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432067", "l": "Aquaporin-4 passively transports water out of cell (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44126", "l": "CoA + tetradecanyl hexadecanoate => hexadecanoyl-CoA + tetradecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75448", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41096", "l": "H2O + sphing-4-enine-phosphocholine => H(+) + phosphocholine + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10599", "l": "ATP + L-tyrosyl-[protein] <=> ADP + H(+) + O-phospho-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784598", "l": "NPPA(124-151) binds NPR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614591", "l": "Excess cysteine yields lanthionine and H2S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667761", "l": "KCNMA1:KCNMB1:LRRC52 transports K+ from the cytosol to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50216", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54082", "l": "5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine => 5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51969", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875451", "l": "MET phosphorylates CBL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59743", "l": "L-cysteinyl-[protein] + octadecanoyl-CoA <=> CoA + S-octadecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70828", "l": "L-arginine(in) + L-lysine(out) => L-arginine(out) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43333", "l": "adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042131", "l": "thiamine phosphate phosphatase activity", "d": ["Catalysis of the reaction: thiamine phosphate + H2O = thiamine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10016", "l": "H2O + O-sinapoylcholine = (E)-sinapate + choline + H(+)", "d": []}, {"i": "EC:3.1.1.49", "l": "\"sinapine esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14013", "l": "3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.74456172809515", "identifiers": [{"i": "GO:0016229", "l": "steroid dehydrogenase activity", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11092", "l": "NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19180", "l": "L-lysine <=> (3S)-3,6-diaminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429101", "l": "HMIT co-transports myo-inositol with a proton (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45122", "l": "H(+) + ipsdienone + NADH => (4R)-ipsdienol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705465", "l": "p-Y-STAT1,3,5 dimer binds SOCS3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2090079", "l": "GLB1 hydrolyses linker chain(2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805546", "l": "Keratin type I binds keratin type II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21294", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140826", "l": "zinc:proton antiporter activity", "d": ["Enables the transfer of zinc from one side of a membrane to the other according to the reaction: H+(out) + Zn2+(in) = H+(in) + Zn2+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28655", "l": "glutathione S,S-dioxide + H2O = glutathione + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65906", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine => 3-hydroxy-L-kynurenine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25188", "l": "1,2-dichloroethane + H2O <=> 2-chloroethanol + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17550", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine => 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57190", "l": "glycolate + H(+) + L-arginyl-[protein] => H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53054", "l": "4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxyestrone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49948", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 = (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195251", "l": "Assembly of the destruction complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65096", "l": "a 2-acylglycerol + hexadecanoyl-CoA = a 1-hexadecanoyl-2-acylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45628", "l": "holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein] = holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein]", "d": []}, {"i": "EC:2.3.2.28", "l": "\"L-allo-isoleucyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58793", "l": "ATP + Fe(III)-petrobactin(out) + H2O => ADP + Fe(III)-petrobactin(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36493", "l": "(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59520", "l": "ATP + butanoyl-CoA + hydrogencarbonate = (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46209", "l": "ATP + CoA + eicosanoate => AMP + diphosphate + eicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36609", "l": "(2S,3S)-hydroxyarginine + CO2 + succinate => 2-oxoglutarate + L-arginine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76081", "l": "a dicarboxylate(out) + L-sepiapterin(in) => a dicarboxylate(in) + L-sepiapterin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63258", "l": "1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) => 1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27876", "l": "pyruvate + salicylate => isochorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934688", "l": "RUNX1:CBFB binds the LIFR gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696131", "l": "AOC1 deaminates Hist (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11467", "l": "2 glutathione + L,L-homocystine <=> glutathione disulfide + 2 L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73645", "l": "CTP(in) + IDP(out) => CTP(out) + IDP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033509", "l": "USP9X binds Ub:PEX5L (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0061693", "l": "alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity", "d": ["Catalysis of the reaction: ATP + methylphosphonate = alpha-D-ribose 1-methylphosphonate 5-triphosphate + adenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60203", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19825", "l": "(2E,6E)-farnesyl diphosphate = (+)-aristolochene + diphosphate", "d": []}, {"i": "EC:4.2.3.9", "l": "\"aristolochene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.99.-", "l": "\"Other carbon-nitrogen lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37795", "l": "2 H(+) + 2 NADPH + O2 = 2 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45102", "l": "mitomycin B + S-adenosyl-L-homocysteine => 6-demethylmitomycin B + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15320", "l": "a 2-deoxy-alpha-D-glucoside + H2O <=> 2-deoxy-D-glucose + an alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102179", "l": "24-ethylidenelophenol 4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 24-ethylidenelophenol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57032", "l": "(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O = CO2 + formate + methylamine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59332", "l": "1'-hydroxy-gamma-carotene + A = 1'-hydroxytorulene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26547", "l": "beta-alaninamide + H2O => beta-alanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32067", "l": "8-oxoguanine + H(+) + H2O = NH4(+) + urate", "d": []}, {"i": "EC:3.5.4.32", "l": "\"8-oxoguanine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942052", "l": "Superoxide and nitric oxide react to peroxynitrite in the phagosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70464", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + H2O + O2 => a 2'-deoxyadenosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20558", "l": "2 H(+) + H2O + urea => CO2 + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42973", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a cardiolipin + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62288", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate = (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24972", "l": "calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209293", "l": "Phosphorylation of CI by CKIalphaepsilon (CKIalpha/DCO) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45531", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141437", "l": "Formation of the MCC complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.-.-", "l": "\"Catalysing the translocation carbohydrates and their derivatives\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26203", "l": "ammelide + NH4(+) => ammeline + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236970", "l": "Proteasomal clevage of exogenous antigen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38247", "l": "(9Z)-hexadecenoyl-CoA + hexadecan-1-ol = 1-O-hexadecyl (9Z)-hexadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10511", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate <=> aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9761027", "l": "ZEB2 binds SP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2562541", "l": "TLR4-induced ripoptosome assembly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41340", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 = 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848606", "l": "PTK6 phosphorylates PXN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74200", "l": "aspulvinone E + O2 => (2Z)-2-[(3,4-dioxocyclohexa-1,5-dien-1-yl)methylidene]-4-(4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-olate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71120", "l": "H(+) + hispidin + NADPH + O2 => 3-hydroxyhispidin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51172", "l": "cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42119", "l": "5alpha-androstane-3alpha,17beta-diol + NADP(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12222", "l": "4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-leucine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62447", "l": "L-canavanine + L-ornithine <=> H(+) + L-arginine + L-canaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69453", "l": "3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH => 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166792", "l": "Conversion of C2 into C2a and C2b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62325", "l": "(+)-malbrancheamide B + chloride + FAD + 2 H(+) => (+)-malbrancheamide + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32279", "l": "allantoate + 2 H(+) + 2 H2O = (S)-ureidoglycolate + CO2 + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33908", "l": "4-(methylamino)butanoate + H2O + O2 => 4-aminobutanoate + formaldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62286", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+) => 2 ATP + L-proline + L-tryptophan + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878178", "l": "The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11025", "l": "ATP + NH4(+) => ADP + 2 H(+) + phosphoramidate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726949", "l": "PTGIR binds PTGIR agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11004", "l": "2 H(+) + NADH + O2 + salicylate = catechol + CO2 + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.1", "l": "\"salicylate 1-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32727", "l": "a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA", "d": []}, {"i": "EC:2.3.1.199", "l": "\"very-long-chain 3-oxoacyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57432", "l": "3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] = 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42746", "l": "H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11500", "l": "3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O = 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate", "d": []}, {"i": "EC:3.1.3.45", "l": "\"3-deoxy-manno-octulosonate-8-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0061596", "l": "3-sulfolactaldehyde reductase activity", "d": ["Catalysis of the reaction 2,3-dihydroxypropane-1-sulfonate + NAD+ = 3-sulfolactaldehyde + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769812", "l": "Spike Trimer Translocates to the Plasma Membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38556", "l": "an all-trans-retinyl ester + H2O => a fatty acid + all-trans-retinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047424", "l": "methylenediurea deaminase activity", "d": ["Catalysis of the reaction: 2 H2O + methylenediurea = CO2 + 2 NH3 + N-hydroxymethylurea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.129", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40662", "l": "1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol <=> 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.3", "l": "\"ficain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35323", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13247", "l": "glyoxylate + succinate => D-threo-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34406", "l": "9-cis-10'-apo-beta-carotenal + 2 O2 <=> (11R)-carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68088", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] = a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5603467", "l": "Activated protein C is released from PROCR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006323", "l": "Phospho-JAK2 phosphorylates EPOR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-873917", "l": "Translocation of STAT1 dimer to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14303", "l": "4-pyridoxate + H(+) => 4-pyridoxolactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53802", "l": "lithocholate + ursodeoxycholoyl-CoA => lithocholoyl-CoA + ursodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68447", "l": "5-cis-lycopene + O2 <=> (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47858", "l": "ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GD1a (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672083", "l": "KTN1 binds Kinesin-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42919", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57563", "l": "(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69142", "l": "Recruitment of Dna2 endonuclease (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17305", "l": "H2O + N(omega),N(omega)-dimethyl-L-arginine = dimethylamine + L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030985", "l": "high molecular weight kininogen binding", "d": ["Binding to a kininogen of high molecular mass."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755747", "l": "SARS-CoV-2 N binds MAVS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317387", "l": "PTEN cancer mutants do not dephosphorylate PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419049", "l": "ROCK activation by RHO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9656244", "l": "DRD2 binds DA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45239", "l": "(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008786", "l": "allose 6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49568", "l": "2-glutathionyl-2-methylbut-3-en-1-ol = (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione", "d": []}, {"i": "EC:4.4.1.34", "l": "\"isoprene-epoxide--glutathione S-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625426", "l": "Retrograde IFT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975633", "l": "atROL binds to RBP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49379", "l": "12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68054", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+) => a ribonucleotidyl-ribonucleotide-RNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447130", "l": "Interleukin-23 binds interleukin-23 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58388", "l": "4-aminobenzoate + all-trans-hexaprenyl diphosphate = 4-amino-3-all-trans-hexaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981355", "l": "RASA1 binds RAS:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042731", "l": "PH domain binding", "d": ["Binding to a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649733", "l": "mature p21 RAS binds GDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381608", "l": "cAMP activates EPAC2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0051766", "l": "inositol trisphosphate kinase activity", "d": ["Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52820", "l": "L-serine + succinyl-CoA = CoA + O-succinyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49501", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50284", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.863640214551324", "identifiers": [{"i": "GO:0070569", "l": "uridylyltransferase activity", "d": ["Catalysis of the transfer of an uridylyl group to an acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917839", "l": "apo-Transferrin dissociates from the receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10784", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51942", "l": "(1Z,2S)-2-methylbutanal oxime => (1E,2S)-2-methylbutanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74065", "l": "GNAT1-GTP binds PDE6 and activates it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691004", "l": "XPC binds RAD23 and CETN2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27661", "l": "2-deoxy-alpha-D-ribose 1-phosphate <=> 2-deoxy-D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106367", "l": "(deoxy)nucleoside phosphate kinase activity, dGTP as phosphate donor", "d": ["Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dGTP = a 2'-deoxyribonucleoside 5'-diphosphate + dGDP."]}, {"i": "RHEA:62128", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dGTP = a 2'-deoxyribonucleoside 5'-diphosphate + dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55977", "l": "glutathione + thiosulfate => H(+) + S-sulfanylglutathione + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43341", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18081", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + pentalenene", "d": []}, {"i": "EC:4.2.3.7", "l": "\"pentalenene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0030145", "l": "manganese ion binding", "d": ["Binding to a manganese ion (Mn)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73658", "l": "(S)-nicotine + 2 Fe(III)-[cytochrome c] <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + N-methylmyosmine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163602", "l": "2 phosphorylated HSL monomers -> phosphorylated HSL dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0003886", "l": "DNA (cytosine-5-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38568", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928624", "l": "EPHBs bind EFNBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390886", "l": "HRH4 binds Hist (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782138", "l": "ERCC5 and RPA bind TC-NER site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13632", "l": "(1S,5R)-carveol + NADP(+) <=> (R)-carvone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60158", "l": "ADP + D-galactose(in) + H(+) + phosphate => ATP + D-galactose(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55345", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol => 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928639", "l": "p-EFNB binds GRB4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75862", "l": "Fall Back to Closed Pre-initiation Complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59509", "l": "fumarate + L-cysteinyl-[protein] => S-(2-succinyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051778", "l": "ent-7-alpha-hydroxykaurenoate oxidase activity", "d": ["Catalysis of the reaction: ent-7-alpha-hydroxykaurenoate + NADPH + H+ + O2 = gibberellin 12-aldehyde + NADP+ + 2 H2O. This is the second of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848726", "l": "PTK6 phosphorylates BCAR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25818", "l": "3-aminopropanal + H2O2 + norspermidine => H2O + norspermine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38860", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose => bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003957", "l": "NAD(P)+ transhydrogenase (B-specific) activity", "d": ["Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66321", "l": "2',3'-cGAMP(out) => 2',3'-cGAMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62795", "l": "3 H(+) + NADPH + O2 + 2 rubrofusarin B <=> 2 H2O + NADP(+) + nigerone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14335", "l": "6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol => an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0004180", "l": "carboxypeptidase activity", "d": ["Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66435", "l": "H(+)(out) + L-galactose(out) <=> H(+)(in) + L-galactose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047259", "l": "glucomannan 4-beta-mannosyltransferase activity", "d": ["Catalysis of the reaction: glucomannan(n) + GDP-mannose = glucomannan(n+1) + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25450", "l": "(+)-guaia-6,9-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197958", "l": "FPGS-2 transforms THF to THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61527", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129375", "l": "Elastin cross-linking by lysyl oxidase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23977", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + ATP => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74598", "l": "(2S,3R)-3-methyl-L-aspartate <=> mesaconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25499", "l": "(2E)-geranyl diphosphate <=> (1S,5S)-beta-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43466", "l": "(2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28240", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin => calycosin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879459", "l": "F-actin capping protein is a heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75168", "l": "CTP + NAD(+) => CDP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24119", "l": "(2E)-geranyl diphosphate + H2O <=> (S)-linalool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72313", "l": "glutathione(out) + taurocholate(in) => glutathione(in) + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28584", "l": "ADP + dUTP => ATP + dUDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202703", "l": "CD47 binds SIRP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004054", "l": "arginine kinase activity", "d": ["Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44030", "l": "5-dehydro-4-deoxy-D-glucarate + H2O => L-altrarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29211", "l": "H(+)(out) + inosine(in) = H(+)(in) + inosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-517674", "l": "p-S158,221-HuR binds mRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029272", "l": "Release of PLCG from FCGR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785607", "l": "FANCM binds FAAP24 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72675", "l": "3',5'-cyclic CMP + H2O = CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18164", "l": "acetyl-CoA + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51339", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38214", "l": "hexadecane-1,2-diol + 2 hexadecanoyl-CoA <=> 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050278", "l": "sedoheptulose-bisphosphatase activity", "d": ["Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700137", "l": "ALK:MDK dimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16774", "l": "ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GM1 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40808", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62796", "l": "H(+) + NADPH + O2 + 2 rubrofusarin B = aurasperone A + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19741", "l": "formyl-CoA + H2O = CoA + formate + H(+)", "d": []}, {"i": "EC:3.1.2.10", "l": "\"formyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448591", "l": "Interleukin-32 binds proteinase-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21705", "l": "H2O + L-tyrosine => NH4(+) + phenol + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20366", "l": "phosphoethanolamine + S-adenosyl-L-methionine => H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112392", "l": "Resumption of elongation after recovery from pausing (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625416", "l": "Anterograde IFT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668395", "l": "CHMP7 binds CC2D1B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010647", "l": "ROBO3.1 binds AKAP5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102253", "l": "neoagarobiose 1,3-alpha-3,6-anhydro-L-galactosidase activity", "d": ["Catalysis of the reaction: neoagarobiose + H2O <=> 3,6-anhydro-alpha-L-galactopyranose + beta-D-galactoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29061", "l": "2 H(+)(out) + ubiquinol-8 => 2 H(+)(in) + H2 + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672083", "l": "KTN1 binds Kinesin-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001639", "l": "PLC activating G protein-coupled glutamate receptor activity", "d": ["A G protein-coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75749", "l": "10-hydroxyoctadecanoate + NAD(+) => 10-oxooctadecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43270", "l": "ganglioside GM2 + H(+) + UDP => ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32763", "l": "(3R)-3-methyl-D-ornithine + ATP + L-lysine = (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.59", "l": "\"3-methyl-D-ornithine--L-lysine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000310", "l": "AURKA phosphorylates PLK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74059", "l": "PDE6 hydrolyses cGMP to GMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23153", "l": "a ubiquinone + H(+) + NADH => a ubiquinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005138", "l": "interleukin-6 receptor binding", "d": ["Binding to an interleukin-6 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0008137", "l": "NADH dehydrogenase (ubiquinone) activity", "d": ["Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) <=> NAD+ + ubiquinol + 4 H+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782264", "l": "CTU1:CTU2:URM1 thiolates uridine-34 in tRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63263", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH <=> 4-pyridoxate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63016", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48736", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27846", "l": "(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667619", "l": "AVPR1A,B,2 bind atosiban (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13162", "l": "L-threonine + NAD(+) => (2S)-2-amino-3-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35734", "l": "sn-glycerol 3-phosphate + tetradecanoyl-CoA <=> 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-976801", "l": "Complement factor I complex formation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60134", "l": "a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate => a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68960", "l": "DNA polymerase epsilon binds at the origin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12702", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O => [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51026", "l": "4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+) => H(+) + NADH + O2 + toluene-4-sulfonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46756", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.42", "l": "\"palmitoyl-[glycerolipid] 7-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28933", "l": "4-carboxy-2-hydroxy-cis,cis-muconate => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031775", "l": "lutropin-choriogonadotropic hormone receptor binding", "d": ["Binding to a lutropin-choriogonadotropic hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873927", "l": "Release of STAT1 dimer from active receptor unit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158849", "l": "Phenol can form a sulfate conjugate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443831", "l": "14-3-3-zeta binds Raf1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45576", "l": "(2R)-ethylmalonyl-CoA = (2S)-methylsuccinyl-CoA", "d": []}, {"i": "EC:5.4.99.63", "l": "\"ethylmalonyl-CoA mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37831", "l": "(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 = 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36946", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68328", "l": "(R)-4'-phosphopantetheine + H2O = (R)-pantetheine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50846", "l": "(5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27893", "l": "3'-UMP + H2O <=> phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.45", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48001", "l": "1,6-dihydro-beta-NADP + H(+) + O2 => H2O2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49095", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928617", "l": "EPHB2 binds KALRN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55991", "l": "H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52927", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25977", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034844", "l": "naphthyl-2-methyl-succinate CoA-transferase activity", "d": ["Catalysis of the reaction: naphthyl-2-methyl-succinate + succinyl-CoA = naphthyl-2-methyl-succinyl-CoA + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11513", "l": "salicyl alcohol + UDP-alpha-D-glucose => H(+) + salicin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62205", "l": "1-propanol + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 2 H(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28222", "l": "3-dehydro-L-gulonate + ATP = 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43300", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084990", "l": "Nuclear CMP-Neu5Ac translocates to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654623", "l": "Activated FGFR3 binds FRS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63325", "l": "1,2-dihexadecanoyl-sn-glycerol + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662608", "l": "MT2A binds cadmium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10165", "l": "(2R)-2-phosphoglycerate => H2O + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029471", "l": "Hydrolysis of PC to PA by PLD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59338", "l": "AH2 + demethylspheroidene => 1-hydroxy-all-trans-1,2-dihydro-neurosporene + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62104", "l": "(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034335", "l": "DNA negative supercoiling activity", "d": ["Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52425", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48096", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.319", "l": "\"type I protein arginine methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654404", "l": "Activated FGFR2 binds SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31530", "l": "N(omega)-hydroxy-L-arginine <=> (S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607740", "l": "PKC-delta phosphorylates CARD9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001154", "l": "TFIIIB-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase III transcription factor belonging to the TFIIB complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390674", "l": "ADRB1 bind ADR,NAd (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-170159", "l": "Translocation of Cdc25 to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106267", "l": "3,5 dichloro-THPH synthase activity", "d": ["Catalysis of the reaction: (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O."]}, {"i": "RHEA:64360", "l": "(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25716", "l": "N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102975", "l": "versiconal hemiacetal acetate reductase activity", "d": ["Catalysis of the reaction: versiconol acetate + NADP <=> versiconal hemiacetal acetate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018524", "l": "acetophenone carboxylase activity", "d": ["Catalysis of the reaction: acetophenone + CO2 = H+ + benzoyl acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73932", "l": "Resynthesis of excised residue by POLB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917696", "l": "Cargo Sequestration (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75062", "l": "chloride(out) + 2 hydrogencarbonate(in) + K(+)(in) <=> chloride(in) + 2 hydrogencarbonate(out) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28450", "l": "N(6)-(D-psicosyl)-L-lysine(in) = N(6)-(D-psicosyl)-L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350604", "l": "Agmatine + H2O <=> putrescine + urea (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373746", "l": "SEMA4D interacts with CD45 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38260", "l": "(2R,3S)-beta-methylmalyl-CoA => glyoxylate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760097", "l": "AcK-NFE2L2 and MAFK bind the GSTA1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952371", "l": "MDM2 binds RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67561", "l": "3'-phosphoadenylyl sulfate + taurocholate => adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654224", "l": "Activated FGFR3 binds PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983156", "l": "Polyubiquitination of substrate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41214", "l": "(indol-3-yl)acetate + H(+) + NADH + O2 <=> 2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443780", "l": "Cis-heterodimerization of L1 and DM-GRASP/ALCAM/BEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42170", "l": "5beta-pregnan-3,20-dione + H(+) + NADPH => 20alpha-hydroxy-5beta-pregnan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14211", "l": "diphosphate + UDP-alpha-D-galactose => alpha-D-galactose 1-phosphate + H(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699575", "l": "FOXO3-dependent CDKN1B gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74557", "l": "(S)-malate(in) => (S)-malate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050199", "l": "piperidine N-piperoyltransferase activity", "d": ["Catalysis of the reaction: (E,E)-piperoyl-CoA + piperidine = N-[(E,E)-piperoyl]piperidine + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9612509", "l": "SGK phosphorylates SRF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33233", "l": "heme d cis-diol => H2O2 + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793383", "l": "Expression of TBX6 in paraxial mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9010872", "l": "SLIT2 binds Dystroglycan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20998", "l": "(3E)-2-oxohex-3-enedioate + NH4(+) => (2Z,4E)-2-aminomuconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13430", "l": "2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) => 4-CDP-2-C-methyl-D-erythritol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61679", "l": "holo-[peptidyl-carrier protein] + L-cysteinyl-5'-AMP <=> AMP + H(+) + L-cysteinyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11282", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102920", "l": "acyl coenzyme A: isopenicillin N acyltransferase activity", "d": ["Catalysis of the reaction: octanoyl-CoA + isopenicillin N + H2O <=> H+ + coenzyme A + penicillin K + L-2-aminoadipate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40386", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP <=> 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690740", "l": "CD22 binds B-cell receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878056", "l": "RUNX1:CBFB binds EP300 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77609", "l": "Binding of APOBEC-1 to form editosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032181", "l": "dinucleotide repeat insertion binding", "d": ["Binding to a double-stranded DNA region containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33948", "l": "2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine => 2'-N-acetylparomamine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18273", "l": "H2O + O2 + putrescine = 4-aminobutanal + H2O2 + NH4(+)", "d": []}, {"i": "EC:1.4.3.10", "l": "\"putrescine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63484", "l": "2-oxoglutarate + L-prolyl-[protein] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106373", "l": "3-deoxyglucosone dehydrogenase activity", "d": ["Catalysis of the reaction: 3-deoxyglucosone + H2O + NAD+ = 2-dehydro-3-deoxy-D-gluconate + 2 H+ + NADH."]}, {"i": "RHEA:67244", "l": "3-deoxyglucosone + H2O + NAD(+) = 2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30639", "l": "(R)-glycerate + GDP-alpha-D-mannose = (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.269", "l": "\"mannosylglycerate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.1", "l": "\"exoribonuclease II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849882", "l": "SALMs 1-4 bind reticulon 3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36177", "l": "1-O-alkyl-sn-glycero-3-phosphate + NADP(+) => 1-O-alkylglycerone 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38679", "l": "ATP + H2O + sphinganine(in) = ADP + H(+) + phosphate + sphinganine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75921", "l": "dihydroxyacetone + H(+) + NADPH + NH4(+) => H2O + NADP(+) + serinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73857", "l": "5alpha,6beta,17alpha-trihydroxywithanolide 27-O-beta-D-glucoside + H(+) + UDP => 5alpha,6beta,17alpha,27-tetrahydroxywithanolide + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69085", "l": "acrolein + H2O + NAD(+) => acrylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21065", "l": "[protein]-disulfide + 2 glutathione => [protein]-dithiol + glutathione disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244503", "l": "botE HC:LC binds SV2A or B and GT1b on the target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24331", "l": "7,8-dihydrofolate + ATP + formate <=> 10-formyldihydrofolate + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619756", "l": "NR1H2 binds ABCA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034919", "l": "butyryl-CoA 2-C-propionyltransferase activity", "d": ["Catalysis of the reaction: 2-methyl-3-oxohexanoyl-CoA + CoA = propanoyl-CoA + butyryl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35683", "l": "hexadecasphinganine + NADP(+) = 3-oxohexadecasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67338", "l": "CoA + kaempferol 3-O-(6-O-malonyl-beta-D-glucoside) => kaempferol 3-O-beta-D-glucoside + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0032217", "l": "riboflavin transmembrane transporter activity", "d": ["Enables the transfer of riboflavin from one side of a membrane to the other. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28833", "l": "D-gluconate(out) + H(+)(out) => D-gluconate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46450", "l": "cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr) => 2 L-tyrosyl-tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53687", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 <=> 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17838", "l": "2-carboxy-D-arabinitol 1-phosphate + H2O => 2-carboxy-D-arabinitol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167284", "l": "7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4411383", "l": "NLK phosphorylates TCF/LEF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32996", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66740", "l": "ATP + H2O + N-acetyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781953", "l": "YOD1 binds VCP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8987007", "l": "p-STAT1 dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47731", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose <=> (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43089", "l": "5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine => 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36052", "l": "beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O => 2 beta-L-arabinofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051700", "l": "fructosyl-amino acid oxidase activity", "d": ["Catalysis of the reaction: fructosyl-amino acid + O2 = corresponding amino acid + glucosone + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55696", "l": "a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O = an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35055", "l": "3,6-dichlorocatechol + O2 = (2E,4E)-2,5-dichloromuconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16832", "l": "an aldehyde + H2O + O2 <=> a carboxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372542", "l": "Loading of dopamine into synaptic veiscles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451418", "l": "Pellino ubiquitinates IRAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193700", "l": "p75NTR ICD signals to NF-kB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52704", "l": "H2O + UMP = D-ribose 5-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174209", "l": "Phosphorylated Emi1 binds the beta-TrCP in the SCF complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909724", "l": "Recruitment of IFNAR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196026", "l": "Dab2 is recruited to the junctional plaques (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2089971", "l": "Secretion of collagens (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72966", "l": "acetoacetate(out) + 2 Na(+)(out) <=> acetoacetate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29450", "l": "glycolate(in) <=> glycolate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32899", "l": "1,8-cineole + O2 + reduced [flavodoxin] = 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]", "d": []}, {"i": "EC:1.14.14.133", "l": "\"1,8-cineole 2-endo-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42374", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine => 16-methoxytabersonine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749647", "l": "CES2 hydrolyzes ASA- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73255", "l": "(2S)-sakuranetin + S-adenosyl-L-methionine = (2S)-naringenin 4',7-dimethyl ether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102298", "l": "selenocystathione synthase activity", "d": ["Catalysis of the reaction: L-selenocysteine + O-phosphonato-L-homoserine = hydrogenphosphate + L-selenocystathionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21435", "l": "(S)-malate + NAD(+) <=> H(+) + NADH + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19792", "l": "4-(dimethylamino)azobenzene + H2O + NADP(+) <=> 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76005", "l": "glutarate(out) + xanthurenate(in) => glutarate(in) + xanthurenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70539", "l": "GDP-beta-L-fucose + L-threonyl-[EGF-like domain protein] = 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39329", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O => (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70899", "l": "histidine => urocanate + NH4+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60513", "l": "a guanosine in miRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40059", "l": "decanoyl-CoA + H2O = CoA + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351894", "l": "Caspase mediated cleavage of BAP31 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53375", "l": "5,6-dihydrouridine(17) in tRNA + NAD(+) <=> H(+) + NADH + uridine(17) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222583", "l": "MscR reduces nitrosomycothiol to ammonia (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39050", "l": "26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63893", "l": "ATP + H2O + L-tryptophan => AMP + D-tryptophan + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69275", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate <=> allyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60963", "l": "18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose <=> (9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45195", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55554", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043863", "l": "4-hydroxy-2-ketopimelate aldolase activity", "d": ["Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051978", "l": "lysophospholipid:sodium symporter activity", "d": ["Enables the directed movement of lysophospholipids from one side of a membrane to the other. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16264", "l": "L-lysyl-[protein] + succinyl-CoA <=> CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28830", "l": "L-ornithine(out) + putrescine(in) <=> L-ornithine(in) + putrescine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34486", "l": "4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA <=> 4-hydroxybenzalacetone + 2 CO2 + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351604", "l": "Noradrenaline translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912363", "l": "PRDM9 binds recombination hotspot motifs in DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5632652", "l": "Hh-Npp binds CDON and PTCH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35061", "l": "chloramphenicol(out) + H(+)(in) => chloramphenicol(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25461", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + sibirene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24582", "l": "D-sorbitol + phosphate => D-sorbitol 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35309", "l": "2,5-dihydroxybenzoate + H2O + NAD(+) => H(+) + NADH + O2 + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30715", "l": "(2E)-geraniol = (S)-linalool", "d": []}, {"i": "EC:5.4.4.4", "l": "\"geraniol isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51723", "l": "ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015068", "l": "glycine amidinotransferase activity", "d": ["Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25842", "l": "5-dehydro-2-deoxy-D-gluconate => 5-deoxy-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64275", "l": "benzylamine + pyruvate <=> benzaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43847", "l": "(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 <=> (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237160", "l": "MTA is cleaved and phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11898", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADH => 7alpha-hydroxycholesterol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31145", "l": "3-oxohexanoyl-CoA + H(+) + NADH => (3S)-hydroxyhexanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60522", "l": "2 glycine + L-cystine => 2 H2O + L-cystine-bis-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40621", "l": "2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+) => H2O + tridodecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51413", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => (8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70613", "l": "H(+) + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein] => L-lysyl-[protein] + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41991", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27948", "l": "3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+) => dopamine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677050", "l": "Formation of the GCN5-ATAC complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83677", "l": "C4 deamination of cytidine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987120", "l": "JAK1 binds IFNLR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5622134", "l": "CRABP1 binds atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863494", "l": "ASICs bind STOML3, (STOM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166538", "l": "The bound receptor dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659899", "l": "Defective SI does not hydrolyze maltotriose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357432", "l": "AXL binds SRC-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102119", "l": "gibberellin A20 carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: gibberellin A20 + S-adenosyl-L-methionine <=> gibberellin A20 methyl ester + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950387", "l": "CANX binds EBI3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30566", "l": "dimethylallyl diphosphate + L-tryptophan <=> 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5656070", "l": "FGFBPs bind FGFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19720", "l": "H(+) + L-phenylalanine <=> 2-phenylethylamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964619", "l": "PAK1 binds ARHGEF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19427", "l": "5-hydroxyimidazole-4-acetate + H2O + NAD(+) => H(+) + imidazole-4-acetate + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28340", "l": "crotonobetainyl-CoA + H2O => (R)-carnitinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15227", "l": "diphosphate + dTDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + dTTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983147", "l": "Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604712", "l": "Initial activation of proMMP7 by trypsin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038025", "l": "reelin receptor activity", "d": ["Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52888", "l": "N-phenylhydroxylamine + NADP(+) = H(+) + NADPH + nitrosobenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59196", "l": "holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP = AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938121", "l": "SERPINB13 binds CTSK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54547", "l": "1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine <=> 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63681", "l": "(7R,8S)-7,8-diammoniononanoate + CO2 => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050130", "l": "N-methyl-2-oxoglutaramate hydrolase activity", "d": ["Catalysis of the reaction: N-methyl-2-oxoglutaramate + H2O = 2-oxoglutarate + methylammonium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72621", "l": "Ribosomal scanning  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071208", "l": "histone pre-mRNA DCP binding", "d": ["Binding to the downstream cleavage product (DCP) generated by histone pre-mRNA 3'-end processing."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635839", "l": "ULK3:SUFU dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66065", "l": "2-oxohexanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46179", "l": "2-methylpropanoate + ATP + CoA <=> 2-methylpropanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12511", "l": "loganate + S-adenosyl-L-methionine <=> loganin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69205", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + L-glutamate => ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847968", "l": "PTEN binds FRK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35377", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate => (beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20665", "l": "1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.263", "l": "\"1,5-anhydro-D-fructose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0017024", "l": "myosin I binding", "d": ["Binding to a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901604", "l": "dethiobiotin transmembrane transporter activity", "d": ["Enables the transfer of dethiobiotin from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22012", "l": "precorrin-4 + S-adenosyl-L-methionine = precorrin-5 + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.133", "l": "\"precorrin-4 C(11)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658435", "l": "RAS GAPs bind RAS:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53841", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADP(+) => 7,12-dioxo-lithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19199", "l": "adenosine 5'-phosphoramidate + 2 H(+) + sulfate => adenosine 5'-phosphosulfate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73394", "l": "H(+)(in) + phosphate(in) + sulfate(out) <=> H(+)(out) + phosphate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035797", "l": "tellurite methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to tellurite [TeO3(2-)]. Methylated derivatives of tellurite include Te(CH3)2 (dimethyltelluride) and Te2(CH3)2 (dimethylditelluride)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65636", "l": "sphinga-(4E,8E)-dienine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422320", "l": "Heterotrimeric G(s) complex dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794475", "l": "Cipro:ALB dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18329", "l": "(1S,3R,5S)-sabinol + NAD(+) = (1S,5S)-sabinone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.228", "l": "\"(+)-sabinol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434650", "l": "MATEs mediate extrusion of xenobiotics (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.58", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909729", "l": "Activation of JAK kinases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16556", "l": "aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] <=> H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102666", "l": "indole-3-acetyl-beta-4-D-glucose hydrolase activity", "d": ["Catalysis of the reaction: indole-3-acetyl-beta-4-D-glucose + H2O <=> H+ + indole-3-acetate + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61860", "l": "dehydroprobetaenone I + H(+) + NADPH + O2 = epoxybetaenone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2672196", "l": "Viral serpin blocks caspase-8 activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236939", "l": "Interaction of exogenous soluble antigen with its corresponding receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008201", "l": "heparin binding", "d": ["Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52189", "l": "1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69234", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+) => (Z)-3-hydroxypropyl glucosinolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13238", "l": "D-fructose 6-phosphate + L-glutamine => D-glucosamine 6-phosphate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416683", "l": "SEMA3E binds to PLXND1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17113", "l": "H2O + L-serine-phosphoethanolamine = H(+) + L-serine + phosphoethanolamine", "d": []}, {"i": "EC:3.1.4.13", "l": "\"serine-ethanolaminephosphate phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675431", "l": "PP2A dephosphorylates RAF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5651828", "l": "PARG dePARylates PARP1,PARP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36750", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51260", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] = (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47175", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) <=> 5alpha-cholest-8-en-3-one + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72650", "l": "1,6-dihydroxyphenazine + NADPH + O2 <=> 1,6-dihydroxyphenazine N(5)-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689000", "l": "AADAC deacetylates PHEN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52602", "l": "CoA + H(+) + N-propanoyl-L-methioninate => L-methionine + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683925", "l": "ULK1 is dephosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38289", "l": "(3S)-citramalyl-CoA + succinate => (3S)-citramalate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624954", "l": "INPP5E translocates to the primary cilium (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47709", "l": "ADP + alpha-D-glucose 1-phosphate + H(+) => ADP-alpha-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888577", "l": "Synthesis of GABA by GAD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691004", "l": "XPC binds RAD23 and CETN2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052859", "l": "glucan endo-1,4-beta-glucosidase activity", "d": ["Catalysis of the random hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392195", "l": "Gi activation by P2Y purinoceptor 12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55874", "l": "2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH => anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49521", "l": "2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2 => an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65697", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine => a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65595", "l": "8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149432", "l": "Transport of VPU to Plasma Membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626699", "l": "MARK4 binds ODF2 in the centriole (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944250", "l": "Association of procollagen type XXV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57158", "l": "4-hydroxy-L-lysyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046353", "l": "aminoglycoside 3-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 3-N-acetylaminoglycoside. This is acetylation of the 3-amino group of the central deoxystreptamine ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63823", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) <=> H(+) + holo-[aryl-carrier protein] + petrobactin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60136", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 = a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50940", "l": "L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) = cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)", "d": []}, {"i": "EC:2.3.2.20", "l": "\"cyclo(L-leucyl-L-phenylalanyl) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006332", "l": "JAK2 transphosphorylates and is activated in response to Erythropoietin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69979", "l": "(22R,23R)-22,23-dihydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45876", "l": "2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40594", "l": "decanedioyl-CoA + H2O <=> CoA + decanedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25397", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018746", "l": "RHOQ binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63709", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21848", "l": "(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide", "d": []}, {"i": "EC:5.2.1.6", "l": "\"furylfuramide isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49373", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate => H2O + NAD(+) + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69688", "l": "genistein 7-O-beta-D-glucoside + H2O => beta-D-glucose + genistein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28337", "l": "dATP + H2O <=> dAMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43185", "l": "S-adenosyl-L-methionine + uridine(2843) in 25S rRNA => H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54012", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672973", "l": "MAP2Ks phosphorylate MAPKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102356", "l": "isoitalicene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + (+)-isoitalicene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60241", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64511", "l": "acetyl-CoA + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine <=> 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + 4 CO2 + 5 CoA + H2O + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44012", "l": "(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) = (9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109860", "l": "MAP2K1 phosphorylates MAPK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220988", "l": "NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34575", "l": "2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone", "d": []}, {"i": "EC:1.14.19.8", "l": "\"pentalenolactone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047275", "l": "glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = D-galactosyl-N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419490", "l": "Binding of ATP to P2X receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371527", "l": "HSF1 trimer translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936007", "l": "CLDN5 (Claudin-5) gene expression is stimulated by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030975", "l": "thiamine binding", "d": ["Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167282", "l": "2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.36", "l": "\"RING-type E3 ubiquitin transferase (cysteine targeting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114553", "l": "Activation of conventional Protein Kinase C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50338", "l": "H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60230", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54500", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = beta-geranylfarnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389970", "l": "Actin/tubulin:prefoldin complex associates with CCT/TriC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38116", "l": "(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol => 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53624", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + tsukubadiene", "d": []}, {"i": "EC:4.2.3.159", "l": "\"tsukubadiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42243", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58732", "l": "5-methyl-CTP + H2O = 5-methyl-CMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2530429", "l": "Formation of soluble VTN:C5b-C9  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22332", "l": "(3R)-citramalate = 2-methylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61147", "l": "myricetin + UDP-beta-L-rhamnose <=> H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22048", "l": "7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate", "d": []}, {"i": "EC:4.2.3.12", "l": "\"6-pyruvoyltetrahydropterin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35927", "l": "paromamine + UDP-alpha-D-glucose = 3''-deamino-3''-hydroxykanamycin C + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5632652", "l": "Hh-Npp binds CDON and PTCH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58459", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O <=> (R)-glycerate + D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34945", "l": "arbutin 6-phosphate(in) + pyruvate(in) => hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640167", "l": "RRAGA,B exchanges GDP for GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662818", "l": "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25931", "l": "3-methylquinoline + A + H2O <=> 3-methylquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009309", "l": "RUNX2 binds STUB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674018", "l": "BRAP binds RAS:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17213", "l": "UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-mannosamine", "d": []}, {"i": "EC:5.1.3.14", "l": "\"UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16370", "l": "(R)-lactate + NAD(+) => H(+) + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-380930", "l": "Phosphorylated AMPK binds AMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686430", "l": "MUS81 binds EME1, EME2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66191", "l": "3',5'-cyclic GMP(in) + ATP + H2O <=> 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59360", "l": "carnosine + H2O = beta-alanine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45912", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0031841", "l": "neuropeptide Y receptor binding", "d": ["Binding to a neuropeptide Y receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54646", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O => trans-4-hydroxy-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61790", "l": "AMP + diphosphate + L-tryptophyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73441", "l": "(2S)-carthamidin-4',7-dimethyl ether + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71058", "l": "L-cysteine(out) + L-methionine(in) <=> L-cysteine(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36783", "l": "L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.108", "l": "\"2-(3-amino-3-carboxypropyl)histidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380158", "l": "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19956", "l": "a 2-oxocarboxylate + L-alanine <=> an L-alpha-amino acid + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45703", "l": "glycine betaine + H(+) + NADH + O2 <=> formaldehyde + H2O + N,N-dimethylglycine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0003713", "l": "transcription coactivator activity", "d": ["A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433593", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1370505", "l": "PRLR is phosphorylated at Ser-349 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5615668", "l": "AKR1C3 reduces atRAL to atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70955", "l": "H(+)(in) + L-glutamate(in) = H(+)(out) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38702", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24508", "l": "NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin E2", "d": []}, {"i": "EC:1.1.1.189", "l": "\"prostaglandin-E2 9-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30111", "l": "Fe(III)-enterobactin + H(+) + 3 H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}, {"i": "EC:3.1.1.108", "l": "\"iron(III) enterobactin esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68772", "l": "(2Z,6Z)-farnesyl diphosphate = diphosphate + germacrene C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29049", "l": "a menaquinol + 2 H(+)(out) => a menaquinone + 2 H(+)(in) + H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22869", "l": "3-chloro-L-alanine + thioglycolate => chloride + H(+) + S-carboxymethyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54984", "l": "a ubiquinol = a ubiquinone + 2 e(-) + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016157", "l": "sucrose synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28408", "l": "H(+) + phosphate + XDP => H2O + XTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32132", "l": "(2S)-ethylmalonyl-CoA + H(+) => butanoyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25651", "l": "(6R)-isopiperitenone + H(+) + NADPH => (2R,5R)-isopulegone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58844", "l": "(6E)-8-hydroxygeranial + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41475", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634418", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047817", "l": "D-arginase activity", "d": ["Catalysis of the reaction: D-arginine + H2O = D-ornithine + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58406", "l": "H(+) + hexanal + NADPH => hexan-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31489", "l": "H(+) + soyasaponin III + UDP => soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429699", "l": "CERT1-2 binds ceramide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33863", "l": "menaquinone-7 + succinate = fumarate + menaquinol-7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72728", "l": "UDP-alpha-D-glucuronate(in) + UMP(out) => UDP-alpha-D-glucuronate(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947535", "l": "Cyclisation of GTP to precursor Z (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19456", "l": "2-oxoglutarate + L-alanine <=> L-glutamate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12181", "l": "anthranilate + S-adenosyl-L-methionine => H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168777", "l": "Metalloprotease cleavage of GHR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209179", "l": "ERF inhibits ETS2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71904", "l": "guanine + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-guanine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112430", "l": "Formation of P-TEFb complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2995330", "l": "COX10 transforms heme to heme O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799350", "l": "Exocytosis of specific granule membrane proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948757", "l": "AKT phosphorylates MKRN1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25422", "l": "3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate => 3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674140", "l": "PAQR3 binds inactive RAFs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624953", "l": "ARL13B binds INPP5E (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42076", "l": "2-hydroxyglutarate + acetyl-CoA = 2-hydroxyglutaryl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69908", "l": "2 Na(+)(out) + uridine(out) => 2 Na(+)(in) + uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74775", "l": "kaempferide + S-adenosyl-L-methionine = 7,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174058", "l": "Degradation of multiubiquitinated Cdh1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13682", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine => a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10743", "l": "a secondary alcohol + NAD(+) <=> a ketone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40540", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57149", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014456", "l": "GDIs block activation of RHOG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21156", "l": "(2R)-2-phosphoglycerate + H2O = (R)-glycerate + phosphate", "d": []}, {"i": "EC:3.1.3.20", "l": "\"phosphoglycerate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44497", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine => 2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9669854", "l": "KIT binds type II TKIs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63157", "l": "H2O + N-docosanoyl-taurine => docosanoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019806", "l": "bromide peroxidase activity", "d": ["Catalysis of the reaction: 2 R-H + 2 bromide + H2O2 = 2 R-Br + 2 H2O. Enzymes with this activity often accept other halide ions as substrates, including chloride and iodide."]}, {"i": "EC:1.11.1.18", "l": "\"bromide peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55980", "l": "a 1,2-saturated acyl-CoA + an acyl-CoA + H2O = an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)", "d": []}, {"i": "EC:2.3.3.20", "l": "\"acyl-CoA:acyl-CoA alkyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35502", "l": "11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75509", "l": "n H(+)(in) + taurocholate(in) => n H(+)(out) + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49523", "l": "2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2 <=> an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15357", "l": "5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose = demethyllactenocin + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.317", "l": "\"O-mycaminosyltylonolide 6-deoxyallosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632958", "l": "PMS2 variants-defective DNA mismatch repair (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20267", "l": "cis-3-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + L-proline + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51474", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047698", "l": "beta-alanyl-CoA ammonia-lyase activity", "d": ["Catalysis of the reaction: beta-alanyl-CoA = acryloyl-CoA + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874685", "l": "CBL binds MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55956", "l": "(9Z)-octadecenoate + AH2 + O2 = (12R)-hydroxy-(9Z)-octadecenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380508", "l": "Translocation of NuMA to the centrosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55922", "l": "(4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3) => [cis-1,4-isoprene](n) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49375", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate <=> H2O + NAD(+) + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805276", "l": "CDK5 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624494", "l": "RAF1 binds p21 RAS:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15150", "l": "O2 + pyridoxine 5'-phosphate => H2O2 + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16974", "l": "2-hydroxypyridine + AH2 + O2 => 2,5-dihydroxypyridine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9724745", "l": "PLG(20-810) binds aprotinin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-500708", "l": "GRIK3 homomer binds glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.47", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296127", "l": "Activation of voltage gated Potassium channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53751", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose <=> a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43747", "l": "ATP + cytidine(34) in tRNA(Ile2) + L-lysine <=> AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692408", "l": "NPR2 binds NPPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38553", "l": "(R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869575", "l": "TFAP2A in complex with DEK binds the APOE gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787591", "l": "TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72052", "l": "butanoate(out) + estrone 3-sulfate(in) => butanoate(in) + estrone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66989", "l": "4-methylpentanoate + ATP + CoA => 4-methylpentanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114284", "l": "Release of Cytochrome c from mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9734687", "l": "ORC6 is phosphorylated on T195 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202164", "l": "Translocation of PDK1 to Plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41338", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669158", "l": "NF2 binds PAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070737", "l": "protein-glycine ligase activity, elongating", "d": ["Catalysis of the posttranslational transfer of one or more glycine residues to a glycine residue covalently attached to the gamma-carboxyl group of a glutamate residue on a target protein, resulting in the elongation of a polyglycine side chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507875", "l": "Aquaporins passively transport urea into cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28827", "l": "L-ornithine(out) + putrescine(in) = L-ornithine(in) + putrescine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24944", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) => (4S)-4-hydroxy-L-glutamate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193646", "l": "NGF binding to p75NTR inactivates RHOA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0047152", "l": "methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity", "d": ["Catalysis of the reaction: 5-hydroxybenzimidazolylcobamide + methanol = H2O + Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709454", "l": "EPOR binds EPOR agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28271", "l": "acetyl-CoA + spermidine => CoA + H(+) + N(8)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382055", "l": "Grb7 binds to the active PDGF receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11105", "l": "N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine => H(+) + hercynine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428511", "l": "NCK binds ROBO1:SLIT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56524", "l": "A + dihydro-heme d1 = AH2 + heme d1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36008", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57853", "l": "a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O => 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66865", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + quiannulatene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49858", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043826", "l": "sulfur oxygenase reductase activity", "d": ["Catalysis of the reaction: 5 sulfur + oxygen + 4 H2O = sulfite + thiosulfate + 2 hydrogen sulfide + 9 H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048248", "l": "CXCR3 chemokine receptor binding", "d": ["Binding to a CXCR3 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17475", "l": "7,8-dihydroneopterin 3'-triphosphate + formate + H(+) => GTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4411383", "l": "NLK phosphorylates TCF/LEF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39719", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate = 24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37050", "l": "H(+)(out) + L-histidine(out) <=> H(+)(in) + L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939204", "l": "ESTG binds ESR1:chaperone complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25783", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine <=> 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13937", "l": "4-sulfobenzoate + NADH + O2 = 3,4-dihydroxybenzoate + NAD(+) + sulfite", "d": []}, {"i": "EC:1.14.12.8", "l": "\"4-sulfobenzoate 3,4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20353", "l": "A + chloride + H(+) + trichloroethene = AH2 + tetrachloroethene", "d": []}, {"i": "EC:1.21.99.5", "l": "\"tetrachloroethene reductive dehalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68531", "l": "(2E,6E)-farnesyl diphosphate <=> beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32054", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate <=> adenosine 5'-tetraphosphate + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939204", "l": "ESTG binds ESR1:chaperone complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65577", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate => an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23056", "l": "urea = cyanamide + H2O", "d": []}, {"i": "EC:4.2.1.69", "l": "\"cyanamide hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48958", "l": "[thyroglobulin]-3-iodo-L-tyrosine + 2 H2O => [thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351894", "l": "Caspase mediated cleavage of BAP31 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12411", "l": "L-lysine + NAD(+) <=> 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21375", "l": "H(+) + H2O + urethane <=> CO2 + ethanol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800797", "l": "The PIDDosome activates CASP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001758", "l": "retinal dehydrogenase activity", "d": ["Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29134", "l": "menaquinol-8 + nitrate <=> H2O + menaquinone-8 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59891", "l": "4-chloro-L-lysine + AH2 + O2 <=> A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44725", "l": "2,3-saturated fatty aldehyde + NADP(+) => (2E)-fatty aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191830", "l": "snRNP nuclear import and release (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696271", "l": "RND1 binds effectors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44061", "l": "2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416683", "l": "SEMA3E binds to PLXND1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10586", "l": "3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+) => 4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0043773", "l": "coenzyme F420-0 gamma-glutamyl ligase activity", "d": ["Catalysis of the reactions: (1) GTP + F420-0 + L-glutamate = GDP + phosphate + F420-1, and (2) GTP + F420-1 + L-glutamate = GDP + phosphate + gamma-F420-2. This is the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174224", "l": "Dissociation of Cdc20 from APC/C complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25042", "l": "H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate => L-selenocysteinyl-tRNA(Sec) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102412", "l": "valerena-4,7(11)-diene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> valerena-4,7(11)-diene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9634850", "l": "NPAS4 binds ARNT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19955", "l": "an L-alpha-amino acid + pyruvate => a 2-oxocarboxylate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66251", "l": "CoA + IC-asc-C9-AMP <=> AMP + H(+) + IC-asc-C9-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382058", "l": "Nck binds to the active PDGF receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15816", "l": "1H-imidazole + acetyl-CoA <=> CoA + N-acetylimidazole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31744", "l": "a 4'-hydroxyflavanone + S-adenosyl-L-methionine => a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046539", "l": "histamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67096", "l": "2-oxoglutarate + asnovolin A + 2 O2 = CO2 + fumigatonoid A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0048406", "l": "nerve growth factor binding", "d": ["Binding to nerve growth factor (NGF)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68541", "l": "(2Z,6Z)-farnesyl diphosphate => (-)-alpha-cedrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41885", "l": "dodecanoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60665", "l": "H2O + NADPH => NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0010011", "l": "auxin binding", "d": ["Binding to auxin, a plant hormone that regulates aspects of plant growth."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.1", "l": "\"chymotrypsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071987", "l": "WD40-repeat domain binding", "d": ["Binding to a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182594", "l": "Association of INK4 family proteins with CDK4/6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140232", "l": "intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential", "d": ["Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38782", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64528", "l": "AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine = 2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64772", "l": "S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine = 2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21986", "l": "adenosine 3',5'-bisphosphate + choline sulfate + H(+) => 3'-phosphoadenylyl sulfate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70529", "l": "an N-acylsphinganine + NAD(+) => H(+) + N-acyl-3-oxosphinganine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45396", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20811", "l": "acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-7-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940959", "l": "Neurolysin degrades neurotensin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9770131", "l": "Formation of the Spliceosomal B* complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0033283", "l": "ATPase-coupled organic acid transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + organic acid(out/in) = ADP + phosphate + organic acid(in/out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41910", "l": "(2E)-hexadecenoyl-[ACP] + H2O => (3R)-hydroxyhexadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9656893", "l": "OPN1MW binds 11cRAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1591234", "l": "ZBP1 binds cytosolic DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710353", "l": "GSDMD (1-275) binds cardiolipin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10870", "l": "a triacyl-sn-glycerol + CoA => a 1,2-diacyl-sn-glycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27536", "l": "(3R,6E)-nerolidol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75341", "l": "chloride(in) + nitrate(out) => chloride(out) + nitrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62595", "l": "(S)-8-oxocitronellyl enol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047419", "l": "N-acetylgalactosamine-6-phosphate deacetylase activity", "d": ["Catalysis of the reaction: H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664879", "l": "ATM:PEX5 binds ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72671", "l": "eIF5B:GTP is hydrolyzed and released (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805943", "l": "S100A1 binds TLR4:LY96 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43030", "l": "2-aminoprop-2-enoate + H(+) + sulfite => L-cysteate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18757", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 = CO2 + cylindrospermopsin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9677050", "l": "Formation of the GCN5-ATAC complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.17", "l": "\"calcium/calmodulin-dependent protein kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353056", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10297", "l": "D-glyceraldehyde 3-phosphate + NADP(+) + phosphate => (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15401", "l": "a dolichyl phosphate + UDP-alpha-D-glucose = a dolichyl beta-D-glucosyl phosphate + UDP", "d": []}, {"i": "EC:2.4.1.117", "l": "\"dolichyl-phosphate beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55557", "l": "a hydroperoxyeicosatetraenoate => an oxoeicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0000009", "l": "alpha-1,6-mannosyltransferase activity", "d": ["Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage."]}, {"i": "REACT:R-HSA-449718", "l": "Addition of a third mannose to the N-glycan precursor by ALG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20241", "l": "nicotinate + S-adenosyl-L-methionine = N-methylnicotinate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.7", "l": "\"nicotinate N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036285", "l": "Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004573", "l": "Glc3Man9GlcNAc2 oligosaccharide glucosidase activity", "d": ["Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443831", "l": "14-3-3-zeta binds Raf1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53258", "l": "7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lathosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264458", "l": "Proteasome mediated degradation of COP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46512", "l": "an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}, {"i": "EC:1.14.18.7", "l": "\"dihydroceramide fatty acyl 2-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199425", "l": "PHLPP dephosphorylates S473 in AKT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61948", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13207", "l": "a UDP-monosaccharide + diphosphate => a monosaccharide 1-phosphate + H(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6790454", "l": "SUMOylation of XPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61248", "l": "H2O + L-tyrosine + O2 = 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64403", "l": "an L-amino acid tripeptide(out) + H(+)(out) <=> an L-amino acid tripeptide(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49886", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990136", "l": "linoleate 9S-lipoxygenase activity", "d": ["Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869694", "l": "oxPL binds CD14 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76052", "l": "Binding of TFIIIA To type 1 Promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60011", "l": "a tRNA precursor + 2 CTP <=> a tRNA with a 3' CC end + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25918", "l": "6-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-6-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.8", "l": "\"glutathionylspermidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30248", "l": "2 H2O + 4 hnu + 2 plastoquinone-9 => O2 + 2 plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250488", "l": "GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46998", "l": "6-hydroxypseudooxynicotine => 6-hydroxy-N-methylmyosmine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16251", "l": "beta-D-glucose 6-phosphate => alpha-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2214351", "l": "PLK1 phosphorylates GORASP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9725855", "l": "NR3C2 binds NR3C2 antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26095", "l": "H2O + limonene 1,2-epoxide + NAD(+) => (4R)-limonene + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23475", "l": "2 alpha,alpha'-trehalose 6-mycolate <=> alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9718020", "l": "PTGFR binds PTGFR agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10737", "l": "a primary alcohol + NAD(+) => an aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28481", "l": "galactarate(in) + H(+)(in) <=> galactarate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34932", "l": "glutathioselenol + NADPH => glutathione + hydrogenselenide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34533", "l": "CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+) => acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050135", "l": "NAD(P)+ nucleosidase activity", "d": ["Catalysis of the reaction: NAD(P)+ + H2O = ADP-ribose(P) + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68464", "l": "2-butyloctyl sulfate + H2O = 2-butyloctan-1-ol + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.22", "l": "\"branched primary-alkylsulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63102", "l": "ascochlorin + 2 H2O + NADP(+) => H(+) + ilicicolin C + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2995330", "l": "COX10 transforms heme to heme O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798374", "l": "DYRK2 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11553", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + H2O => 1-O-alkyl-sn-glycerol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203611", "l": "N-myristoylation of eNOS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55179", "l": "2-oxoglutarate + butanoyl-CoA + O2 <=> 2-hydroxybutanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19210", "l": "codeine + NADP(+) => codeinone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25845", "l": "(1S,5R)-carveol + NAD(+) => (R)-carvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46844", "l": "4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20268", "l": "2-oxoglutarate + L-proline + O2 <=> cis-3-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192051", "l": "CYP7A1 7-hydroxylates CHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.64", "l": "\"testosterone 17beta-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43555", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56085", "l": "[Rab1 protein]-O-phosphocholine-L-serine + H2O => [Rab1 protein]-L-serine + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73858", "l": "5alpha,6beta,17alpha,27-tetrahydroxywithanolide + UDP-alpha-D-glucose <=> 5alpha,6beta,17alpha-trihydroxywithanolide 27-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75501", "l": "cholate(in) + n H(+)(in) => cholate(out) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9656244", "l": "DRD2 binds DA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42242", "l": "1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33582", "l": "NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate <=> H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28562", "l": "D-alanine + pyridoxal 5'-phosphate = pyridoxamine 5'-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015196", "l": "L-tryptophan transmembrane transporter activity", "d": ["Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid."]}, {"i": "REACT:R-HSA-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50597", "l": "acetyl-CoA + N-terminal L-seryl-[histone H4] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044875", "l": "gamma-glutamyl hercynylcysteine sulfoxide synthase activity", "d": ["Catalysis of the reaction: gamma-glutamyl cysteine + hercynine + O2 = gamma-glutamyl-hercynyl cysteine sulfoxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538832", "l": "PP1 dephosphorylates phosphorylated TIM in the complex with PER and DCO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050186", "l": "phosphoadenylylsulfatase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59798", "l": "CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => dodecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.159", "l": "\"alpha-neoagaro-oligosaccharide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "48.026614437012903", "identifiers": [{"i": "GO:0016787", "l": "hydrolase activity", "d": ["Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.117", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44754", "l": "6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45613", "l": "H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29034", "l": "L-glutamate(in) + 2 Na(+)(in) <=> L-glutamate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25668", "l": "beta-pinene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71685", "l": "2 H(+)(in) + L-aspartyl-glycine(in) => 2 H(+)(out) + L-aspartyl-glycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32794", "l": "L-ectoine(in) <=> L-ectoine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75238", "l": "TRAIL binds TRAIL receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56121", "l": "2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14683", "l": "2-aminophenoxazin-3-one + AH2 + 2 H2O => 2 2-aminophenol + A + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043908", "l": "Ser(Gly)-tRNA(Ala) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala) and Gly-tRNA(Ala)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73704", "l": "UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-glucosamine(in) => UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-glucosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10688", "l": "H2O + streptomycin 6-phosphate = phosphate + streptomycin", "d": []}, {"i": "EC:3.1.3.39", "l": "\"streptomycin-6-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23355", "l": "2-oxoglutarate + 4-aminobutanoate <=> L-glutamate + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008110", "l": "L-histidine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38704", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74740", "l": "Binding of SHC1 to insulin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37718", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine <=> 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10197", "l": "(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate => 2-succinylbenzoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60391", "l": "Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016900", "l": "oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule."]}, {"i": "EC:1.1.4.-", "l": "\"With a disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759809", "l": "miR-451a binds CDH11 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47424", "l": "(2E,9Z)-octadecadienoyl-CoA + H2O = (3S)-hydroxy-(9Z-octadecenoyl)-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26236", "l": "(2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640167", "l": "RRAGA,B exchanges GDP for GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332235", "l": "CBL binds TGFBR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-982778", "l": "Growth hormone binds the growth hormone receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730860", "l": "Phosphorylation of GAB2 by SYK/FYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12854", "l": "(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose => dhurrin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34755", "l": "H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine = D-glucose + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015493", "l": "lysine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lysine(out) + H+(out) = lysine(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73800", "l": "SAICAR => AICAR + Fumarate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73967", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49890", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2 => (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086410", "l": "CDK1 phosphorylates BORA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19763", "l": "FMN + H2O + NAD(+) => FMN-N(5)-oxide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-398184", "l": "LARG activation by G alpha 12/13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.47", "l": "\"HIV-2 retropepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37950", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28434", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + tetradecanoyl-[ACP] = ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41512", "l": "L-ornithine + NADH + O2 = H2O + N(5)-hydroxy-L-ornithine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38057", "l": "CDP + H(+) + phytyl phosphate => CTP + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25251", "l": "(2S)-2-acetolactate + CO2 => H(+) + 2 pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002171", "l": "low-affinity IgA receptor activity", "d": ["Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014587", "l": "Transcription of ROBO3.2 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39228", "l": "(2E)-octacosenoyl-CoA + H(+) + NADPH => NADP(+) + octacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73106", "l": "diosmetin + S-adenosyl-L-methionine <=> luteolin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75636", "l": "(9Z)-octadecenoate + O2 => 10-hydroperoxy-(8E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57505", "l": "3-hydroxybutane-1,2,3-tricarboxylate => pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51071", "l": "(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate <=> (3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25142", "l": "(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) <=> 3-amino-2-oxopropyl phosphate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-76031", "l": "2 H2O2 => O2 + 2 H2O (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30886", "l": "D-glucurono-3,6-lactone + 2 H2O + NAD(+) <=> D-glucarate + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26270", "l": "Co-precorrin-2 + 3 H(+) => Co(2+) + precorrin-2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673346", "l": "Unknown kinase phosphorylates p-DVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18360", "l": "NADP(+) + tropine <=> H(+) + NADPH + tropinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218821", "l": "PDK1 phosphorylates PKC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47201", "l": "(24S)-7alpha-dihydroxycholesterol + NAD(+) => (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44327", "l": "1-butyrylglycerol + H2O <=> butanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635861", "l": "NUMB:ITCH binds GLI1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47912", "l": "6-deoxy-6-sulfo-D-gluconate = 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O", "d": []}, {"i": "EC:4.2.1.162", "l": "\"6-deoxy-6-sulfo-D-gluconate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35641", "l": "glyoxylate + pyruvate => (4S)-4-hydroxy-2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25216", "l": "H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534378", "l": "Hv1 Mediated H+ Permeability (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69549", "l": "H(+) + O-phospho-L-serine => CO2 + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23886", "l": "1-methylnicotinamide + S-adenosyl-L-homocysteine => nicotinamide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015487", "l": "melibiose:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + monovalent cation(out) = melibiose(in) + monovalent cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15448", "l": "H(+) + H2O + O-carbamoyl-L-serine <=> CO2 + 2 NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709406", "l": "CO binds to Cytochrome c oxidase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60456", "l": "ATP + UTP = 3',3'-cUAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388817", "l": "ICOS binds ICOSL/B7-H2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372529", "l": "Release of acetylcholine at the synapse (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182171", "l": "Degradation of CD8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32701", "l": "beta-sesquiphellandrene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38014", "l": "chlorophyll a + H2O <=> chlorophyllide a + H(+) + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28852", "l": "melibiose(in) + Na(+)(in) => melibiose(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73384", "l": "thiamine diphosphate(in) + thiamine phosphate(out) => thiamine diphosphate(out) + thiamine phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388560", "l": "EDNRA,EDNRB bind EDNs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062202", "l": "Labd-13(16),14-diene-9-ol synthase activity", "d": ["Catalysis of the reaction: peregrinol diphosphate = diphosphate + labd-13(16),14-diene-9-ol."]}, {"i": "RHEA:62184", "l": "peregrinol diphosphate = diphosphate + labd-13(16),14-diene-9-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.56", "l": "\"insulysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35887", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41963", "l": "ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GA1 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75345", "l": "adenosine(out) => adenosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106312", "l": "methylenetetrahydrofolate reductase NADH activity", "d": ["Catalysis of the reaction: 5-methyltetrahydrofolate + NAD + = 5,10-methylenetetrahydrofolate + NADH + H+."]}, {"i": "RHEA:19821", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390453", "l": "Hydrolysis of ATP and release of folded actin from CCT/TriC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876868", "l": "ECE1 cleaves EDN1(53-90) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23468", "l": "2-aminobenzenesulfonate + 2 H(+) + NADH + O2 = 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)", "d": []}, {"i": "EC:1.14.12.14", "l": "\"2-aminobenzenesulfonate 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67355", "l": "malonyl-CoA + rhaponticin <=> 6-O-malonyl-rhaponticin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36996", "l": "(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32060", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O => (R)-glycerate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71783", "l": "MDH2 reduces OA to MAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52623", "l": "3-methylbutanoyl-CoA <=> 2,2-dimethylpropanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952442", "l": "SPP1 gene expression is stimulated by RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15777", "l": "1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate", "d": []}, {"i": "EC:3.1.3.40", "l": "\"guanidinodeoxy-scyllo-inositol-4-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15715", "l": "a 6-acetyl-beta-D-galactoside + CoA => a beta-D-galactoside + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68665", "l": "17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41672", "l": "1-O-hexadecyl-sn-glycerol + ATP = 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17602", "l": "ATP + D-ribulose => ADP + D-ribulose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49574", "l": "coproporphyrin III + Fe(2+) => Fe-coproporphyrin III + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65018", "l": "4-hydroxychlorothalonil + chloride + 2 H(+) => chlorothalonil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24289", "l": "5-formimidoyltetrahydrofolate + glycine => (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9639286", "l": "RRAGC,D exchanges GTP for GDP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5138459", "l": "WNT5A:FZD4 is endocytosed (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61404", "l": "ATP + N-(D-ribulosyl)-cadaverine = ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27779", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) => 2-all-trans-octaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69363", "l": "bromide + H(+) + H2O2 + L-tyrosyl-[protein] <=> 3-bromo-L-tyrosyl-[protein] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990930", "l": "mRNA N1-methyladenosine dioxygenase activity", "d": ["Catalysis of the oxidative demethylation of N1-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenosine as formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70982", "l": "Fumarate + H2O <=> (S)-Malate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53906", "l": "ADP + H(+) + O-phospho-L-threonyl-[tau protein] => ATP + L-threonyl-[tau protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23929", "l": "H2O + N(8)-acetylspermidine => acetate + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48905", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45740", "l": "2-oxoglutarate + L-ectoine + O2 = 5-hydroxyectoine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.55", "l": "\"ectoine hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39298", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047236", "l": "methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: methylazoxymethanol + UDP-D-glucose = H+ + cycasin + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008111", "l": "alpha-methylacyl-CoA racemase activity", "d": ["Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36181", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-alkyl-2-acyl-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36199", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001855", "l": "complement component C4b binding", "d": ["Binding to a C4b product of the classical complement cascade."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46400", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033997", "l": "inulin fructotransferase (DFA-I-forming) activity", "d": ["Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose-beta-D-fructofuranose 1,2':1,2'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,1'-dianhydride (DFA I) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51397", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin => CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0016673", "l": "oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein."]}, {"i": "EC:1.8.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106291", "l": "superoxide-generating NADH oxidase activity", "d": ["Catalysis of the reaction: NADH + 2 O2 = H+ + NAD+ + 2 superoxide."]}, {"i": "RHEA:63184", "l": "NADH + 2 O2 = H(+) + NAD(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444100", "l": "PROT mediates L-proline uptake (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103027", "l": "FMN phosphatase activity", "d": ["Catalysis of the reaction: FMN + H2O = riboflavin + hydrogenphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44127", "l": "hexadecanoyl-CoA + tetradecan-1-ol <=> CoA + tetradecanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050071", "l": "phosphatidylglycerol lysyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74369", "l": "substance P(in) => substance P(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.13", "l": "\"iduronate-2-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39897", "l": "7-deoxyloganate + H(+) + UDP => 7-deoxyloganetate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390835", "l": "DRD1,5 bind DA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70663", "l": "4-hydroxy-L-proline(in) + H(+)(in) = 4-hydroxy-L-proline(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56473", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25241", "l": "(S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH4(+)", "d": []}, {"i": "EC:3.5.3.26", "l": "\"(S)-ureidoglycine aminohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204863", "l": "Interaction of Tie2 with Ang2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28286", "l": "a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35892", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9676254", "l": "Formation of the MLL3 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23797", "l": "17-O-acetylnorajmaline + H2O => acetate + H(+) + norajmaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34786", "l": "a 3alpha-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54176", "l": "a long-chain fatty aldehyde + holo-[ACP] + NADP(+) = a long-chain fatty acyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57163", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2 <=> (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43083", "l": "O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614933", "l": "ACEIs bind ACE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689630", "l": "BAP1 binds BAP1-interacting complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44891", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55023", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O <=> 5,6-diaminouracil + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209313", "l": "Autocleavage of HH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-213406", "l": "Disassociation of PLC-gamma1 from LAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2529020", "l": "CK2 phosphorylates condensin I subunits (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432535", "l": "TIM is phosphorylated by CK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31138", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate <=> 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0005092", "l": "GDP-dissociation inhibitor activity", "d": ["Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070290", "l": "N-acylphosphatidylethanolamine-specific phospholipase D activity", "d": ["Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60223", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433454", "l": "Phosphorylation of GAB2 by SFKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26240", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (2E,6E,10E)-geranylgeraniol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14088", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA <=> 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43458", "l": "(2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17425", "l": "CoA + NADP(+) + pyruvate = acetyl-CoA + CO2 + NADPH", "d": []}, {"i": "EC:1.2.1.51", "l": "\"pyruvate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.41", "l": "\"bis(5'-nucleosyl)-tetraphosphatase (symmetrical)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-555065", "l": "Formation of clathrin coated vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852324", "l": "GTSE1 binds PLK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193981", "l": "CYP21A2 oxidises 17HPROG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34754", "l": "ATP + N-acyl-15-methylhexadecasphing-4-enine <=> ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.5.-", "l": "\"With a quinone or related compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008399", "l": "naphthalene hydroxylase activity", "d": ["Catalysis of the conversion of naphthalene to naphthalene 1,2-oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73797", "l": "FAICAR => IMP + H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693540", "l": "MRN activates ATM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28548", "l": "alpha-D-fructose => alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55939", "l": "all-trans-4-hydroxyretinol + NAD(+) <=> all-trans-4-hydroxyretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46768", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.27", "l": "\"sn-2 palmitoyl-lipid 9-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32452", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate => all-trans-phytoene + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191402", "l": "Reduction of presqualene diphosphate to form squalene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3878123", "l": "Initiation of SAHF formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75645", "l": "(10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693347", "l": "CRYM reduces P2C to PPCA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909729", "l": "Activation of JAK kinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27335", "l": "2,5-dihydroxypyridine + CO2 + H2O + NAD(+) => 6-hydroxynicotinate + 2 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61553", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20955", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose <=> beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862084", "l": "PILRA,PILRB bind CD99 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5695964", "l": "ABHD14B hydrolyses PNPB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2574845", "l": "AJUBA binds centrosome-associated AURKA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619430", "l": "PPM1E dephosphorylates CAMK4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690461", "l": "FKBP1A binds tacrolimus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39481", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+) => (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36188", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine => 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60844", "l": "a 5'-end diphospho-guanosine in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45892", "l": "an N-acylsphing-4-enine + CDP-ethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912790", "l": "CBL binds CRK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687465", "l": "MRN complex binds RBBP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70483", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in single-stranded DNA + H2O + O2 = a 2'-deoxyguanosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27983", "l": "7-carboxy-7-deazaguanine + ATP + NH4(+) => 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683925", "l": "ULK1 is dephosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0008515", "l": "sucrose transmembrane transporter activity", "d": ["Enables the transfer of sucrose from one side of a membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46730", "l": "(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2 => (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35862", "l": "1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.29", "l": "\"aureolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164834", "l": "Enzyme-bound ATP is released (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602466", "l": "Activation of MT-MMPs by FURIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49734", "l": "CO2 + H2O + violacein => H(+) + O2 + violaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49613", "l": "(R)-2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3159253", "l": "MMAB adenosylates cob(I)alamin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38380", "l": "(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15987", "l": "CO2 + NADH => formate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877348", "l": "RUNX1, FOXP3 and NFATC2 bind the IL2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165680", "l": "Formation of active mTORC1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58755", "l": "1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0032549", "l": "ribonucleoside binding", "d": ["Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61876", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9679044", "l": "FKBP1A binds sirolimus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112690", "l": "PTPN11 binds CBL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25146", "l": "3-hydroxy-L-kynurenine + H2O <=> 3-hydroxyanthranilate + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011313", "l": "Proteasome degrades ubiquitinated ROBO3.1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51794", "l": "2,3-dihydroxybenzoate + H2O + NAD(+) => H(+) + NADH + O2 + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64475", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine <=> (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46129", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60523", "l": "2 H2O + L-cystine-bis-glycine <=> 2 glycine + L-cystine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218806", "l": "FYN autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001862", "l": "collectin binding", "d": ["Binding to a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60084", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) = a 4alpha-methyl-3-oxosteroid + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814088", "l": "SYS1 binds AcM-ARFRP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30145", "l": "CoA + H(+) + octanoate => H2O + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202969", "l": "Caspase mediated cleavage of beta-catenin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70971", "l": "citrate <=> isocitrate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130731", "l": "Formation of COPII vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428749", "l": "Activated TP receptor binds G-proten Gq (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712078", "l": "ALK mutants bind PI3KR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20084", "l": "H2O + N-methylhexanamide <=> hexanoate + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009485", "l": "IL34:CSF1 binds CSF1R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102584", "l": "cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP-alpha-D-glucose <=> cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72911", "l": "proatranorin III + S-adenosyl-L-methionine = atranorin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57828", "l": "dIMP + H2O = 2-deoxy-D-ribose 5-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031892", "l": "type 2 vasoactive intestinal polypeptide receptor binding", "d": ["Binding to a type 2 vasoactive intestinal polypeptide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-500717", "l": "Activation of GRIK3 homomer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55361", "l": "11-cis-retinol => 9-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626039", "l": "pGFAP binds GFAP in LAMP2a multimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42770", "l": "a 2-oxocarboxylate + H(+) + NADPH => a (2S)-2-hydroxycarboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49313", "l": "2-trans,4-trans-xanthoxin + NAD(+) => 2-trans-(+)-abscisic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849646", "l": "SPINK5(490-624) binds KLK5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21146", "l": "5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n) => 5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46344", "l": "propanoyl-CoA + tetradecanoyl-CoA = 3-oxo-2-methylhexadecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68266", "l": "(6S)-5,6,7,8-tetrahydrofolate + formaldehyde => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42862", "l": "1,2-dioctanoyl-sn-glycerol + phosphate => 1,2-dioctanoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804402", "l": "TP53 binds POU4F1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35633", "l": "cyanidin 3-O-beta-D-galactoside + H(+) + UDP => cyanidin + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25456", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-humulene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023859", "l": "Estrogen-responsive TFF1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.777964009505382", "identifiers": [{"i": "GO:0004601", "l": "peroxidase activity", "d": ["Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62309", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) => (+)-malbrancheamide B + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42740", "l": "guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.173", "l": "\"23S rRNA (guanine(2445)-N(2))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694441", "l": "CSNK1D phosphorylates SEC23 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48783", "l": "ATP + L-erythrulose <=> ADP + H(+) + L-erythrulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080049", "l": "L-gulono-1,4-lactone dehydrogenase activity", "d": ["Catalysis of the reaction: L-gulono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2025890", "l": "Calcineurin binds NFATC1,2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36198", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11421", "l": "NADPH + O2 + senecionine => H2O + NADP(+) + senecionine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36692", "l": "octadecanoyl-CoA + sphing-4-enine => CoA + H(+) + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63454", "l": "GMP + H(+) + oxidized 3PG-factor420-0 => 3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11310", "l": "ADP + H(+) + malonyl-CoA + phosphate => acetyl-CoA + ATP + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159771", "l": "Furin cleaves pro-protein C to protein C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63002", "l": "(11Z,14Z,17Z)-eicosatrienoate + NH4(+) => (11Z,14Z,17Z)-eicosatrienamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40588", "l": "H2O + octanedioyl-CoA => CoA + H(+) + octanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668605", "l": "RAC2:GTP binds NOX2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205231", "l": "Dimerization of KIT upon SCF binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23405", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate => diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9676160", "l": "AAMP binds NOD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24071", "l": "cyclohexanone + H(+) + NADPH + O2 <=> H2O + hexano-6-lactone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70589", "l": "acetate + alpha-D-glucosaminyl-[heparan sulfate](n) => H2O + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29036", "l": "ATP + H2O + L-glutamate(out) => ADP + H(+) + L-glutamate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351596", "l": "Dopamine translocates to a secretory vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66930", "l": "a (N(7)-methyl 5'-triphospho-guanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49353", "l": "2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755368", "l": "TLR2:TLR1 binds SARS-CoV-2 E pentamer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0017080", "l": "sodium channel regulator activity", "d": ["Binds to and modulates the activity of a sodium channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211983", "l": "CYP2J2 oxidises ARA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35351", "l": "NADP(+) + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044729", "l": "hemi-methylated DNA-binding", "d": ["Binding to double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks."]}]}
{"type": "biolink:MolecularActivity", "ic": "74.509227218911647", "identifiers": [{"i": "GO:0050839", "l": "cell adhesion molecule binding", "d": ["Binding to a cell adhesion molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693540", "l": "MRN activates ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33188", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54408", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41429", "l": "L-tyrosine + S-adenosyl-L-methionine => 3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730888", "l": "Phosphorylation of PLC-gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964280", "l": "Active Gq binds BTK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64453", "l": "L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690152", "l": "USP5 cleaves polyubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30296", "l": "GTP + pyruvate => GDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29858", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine <=> D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39790", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265301", "l": "Corticotropin cleavage from POMC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432361", "l": "Cytosolic PER is degraded by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61939", "l": "ATP + cycloheximide(in) + H2O <=> ADP + cycloheximide(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005020", "l": "stem cell factor receptor activity", "d": ["Combining with stem cell factor (SCF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36928", "l": "(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031489", "l": "myosin V binding", "d": ["Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018827", "l": "1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity", "d": ["Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethane = HCl + unsym-bis(4-chlorophenyl)ethene. 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS; unsym-bis(4-chlorophenyl)ethene is also known as DDNU."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.18", "l": "\"inulin fructotransferase (DFA-III-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373715", "l": "DCC interaction with ROBO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373734", "l": "Nephrin interacts with Podocin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73103", "l": "diosmetin + S-adenosyl-L-methionine = luteolin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12944", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13907", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4167511", "l": "HLCS biotinylates ACACB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428293", "l": "IGF2BP2 binds specific RNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.38", "l": "\"glutamin-(asparagin-)ase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706399", "l": "RHOBTB3 hydrolyzes ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27743", "l": "2'-deoxyadenosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35367", "l": "(2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH = isoheptadecanoyl-coA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41282", "l": "H2O + N-octadecanoylsphing-4-enine <=> octadecanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685230", "l": "CHEK1 phosphorylates RAD51 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17458", "l": "[sulfur-carrier protein]-L-cysteine + L-cysteine => [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0001846", "l": "opsonin binding", "d": ["Binding to an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050040", "l": "lactate 2-monooxygenase activity", "d": ["Catalysis of the reaction: (S)-lactate + O2 = acetate + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814831", "l": "TBC1D20 binds RAB1:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69964", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45206", "l": "H2O + methyl-Co(III)-[methanol-specific corrinoid protein] => Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149519", "l": "MMACHC decyanates CNCbl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75283", "l": "decanoate + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxydecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13217", "l": "H2O + NAD(+) + succinate semialdehyde = 2 H(+) + NADH + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74384", "l": "2 (S)-lactate(in) + prostaglandin E2(out) => 2 (S)-lactate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420906", "l": "Formation of PPAT tetramers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23248", "l": "myo-inositol + S-adenosyl-L-methionine = 1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.129", "l": "\"inositol 4-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58920", "l": "(3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol = (+)-medicarpin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35117", "l": "(4-coumaroyl)acetyl-CoA + CO2 + CoA => 4-coumaroyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48942", "l": "2 an L-alpha-amino acid => an L-aminoacyl-L-amino acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16789", "l": "a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-990528", "l": "Interaction of PCBP2 with MAVS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48792", "l": "GDP-beta-L-fucose + Lc4Cer = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36993", "l": "alpha-D-ribose 1,5-bisphosphate + uracil => phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15768", "l": "adenosylcob(III)inamide + GTP <=> adenosylcob(III)inamide phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098744", "l": "1-phosphatidylinositol 4-kinase activator activity", "d": ["Binds to and increases the activity of 1-phosphatidylinositol 4-kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161282", "l": "Elastic fibres bind associated proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018679", "l": "dibenzothiophene-5,5-dioxide monooxygenase activity", "d": ["Catalysis of the reaction: dibenzothiophene-5,5-dioxide + O2 + 2 NADH + H+ = 2 NAD+ + H2O + 2'-hydroxybiphenyl-2-sulfinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1364043", "l": "Tyrosine phosphorylation of PRLR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9823816", "l": "OPTN binds CASP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013108", "l": "GDIs block activation of RHOC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25289", "l": "lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74548", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + talarodiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2530429", "l": "Formation of soluble VTN:C5b-C9  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944250", "l": "Association of procollagen type XXV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37466", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112434", "l": "Formation of DSIF complex  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51272", "l": "(9Z)-octadecenoyl-CoA + glycine = CoA + H(+) + N-(9Z-octadecenoyl)glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20846", "l": "ADP + H(+) + oxaloacetate + phosphate => ATP + hydrogencarbonate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59376", "l": "4-amino-4-deoxychorismate = 4-amino-4-deoxyprephenate", "d": []}, {"i": "EC:5.4.99.67", "l": "\"4-amino-4-deoxychorismate mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37013", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603067", "l": "Unknown nuclease cleaves pre-piRNA in ASZ1:DDX4:MOV10L1:6xMeR-PIWIL2:pre-piRNA:TDRD1:TDRD12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52684", "l": "NAD(+) + pyridoxine = H(+) + NADH + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71500", "l": "6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) => 6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53874", "l": "CDP-D-ribose + diphosphate => CTP + D-ribose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56162", "l": "an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP => an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61210", "l": "H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein] => 8-nitro-cGMP + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202216", "l": "Phosphorylation of SLP-76 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033752", "l": "acetylacetone-cleaving enzyme activity", "d": ["Catalysis of the reaction: pentane-2,4-dione + O2 = acetate + 2-oxopropanal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49330", "l": "2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55829", "l": "cortisol + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.36", "l": "\"pancreatic elastase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76058", "l": "norreticuline + S-adenosyl-L-methionine <=> H(+) + reticuline + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11679", "l": "D-ribose + H2O + NADP(+) <=> D-ribonate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5631885", "l": "PRDX1 overoxidizes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852200", "l": "Inactivation of LCK by PTPN22 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66144", "l": "5-methoxytryptamine + acetyl-CoA = CoA + H(+) + melatonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807585", "l": "BPI binds LPS on the bacterial surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64163", "l": "ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide <=> ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424485", "l": "Release of p-PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114558", "l": "Thrombin-activated PARs activate Gq (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727819", "l": "TAK1 phosphorylates MKK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71639", "l": "K(+)(in) + Na(+)(in) = K(+)(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48771", "l": "ATP + D-erythrulose <=> ADP + D-erythrulose 4-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.8.15", "l": "\"3-(aryl)acrylate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451447", "l": "Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58843", "l": "cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43819", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38699", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60986", "l": "16-oxohexadecanoate + H(+) + NADH => 16-hydroxyhexadecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866304", "l": "pre-VLDL binds lipids to form VLDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865454", "l": "CBFB binds RUNX3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48754", "l": "CO2 + H(+) + succinate + validamycin B => 2-oxoglutarate + O2 + validamycin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19866", "l": "4 H(+) + uroporphyrinogen III => 4 CO2 + coproporphyrinogen III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53744", "l": "glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019799", "l": "tubulin N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010290", "l": "chlorophyll catabolite transmembrane transporter activity", "d": ["Enables the directed movement of chlorophyll catabolites such as non-fluorescent chlorophyll catabolites (NCCs), from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685604", "l": "SLAMF6 binds SLAMF6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39073", "l": "(2E)-dodecenedioyl-CoA + H2O2 => dodecanedioyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50415", "l": "L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] <=> H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58940", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADH = all-trans-lycopaoctaene + diphosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2089971", "l": "Secretion of collagens (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592278", "l": "Autocatalytic activation of proMMP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21493", "l": "2,3-dihydroxybenzoate + H(+) => catechol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6790038", "l": "Expression of HSP90B1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388809", "l": "CTLA-4 binds B7-1/B7-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51410", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69799", "l": "D-tryptophanyl-tRNA(Trp) + H2O = D-tryptophan + tRNA(Trp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62204", "l": "1-propanol + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + 2 H(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362522", "l": "ALDHs oxidise atRAL to atRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67643", "l": "ATP + dZMP <=> ADP + dZDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64703", "l": "1-phenylethanol + NAD(+) <=> acetophenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9652264", "l": "ERBB2 binds TKIs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62387", "l": "cyclic (2R)-2,3-bisphosphoglycerate + H2O <=> (2R)-2,3-bisphosphoglycerate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939204", "l": "ESTG binds ESR1:chaperone complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54786", "l": "Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide => Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75728", "l": "(10E,12Z)-octadecadienoate + H2O => (10S)-hydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42218", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018819", "l": "lactoyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: lactoyl-CoA = acryloyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102169", "l": "pyocyanin hydroxylase activity", "d": ["Catalysis of the reaction: 5-methylphenazine-1-carboxylate + NADH + O2 + 2 H+ = pyocyanin + NAD + carbon dioxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868071", "l": "Clathrin recruits PIK3C2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140625", "l": "opioid growth factor receptor activity", "d": ["Combining with the opioid growth factor (OGF, met-enkephalin) and transmitting the signal across the nuclear membrane. Met-enkephalin is an endogenous opioid peptide that binds to opioid and opioid growth factor receptors, regulating tissue growth in a variety of cellular processes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37977", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate => H(+) + homogentisate + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56609", "l": "5,10-methylenetetrahydrosulfopterin + glycine + H2O => L-serine + tetrahydrosulfopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10333", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244415", "l": "botA HC:LC binds SV2A, B, or C and GT1b on the target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50111", "l": "hexadecanoyl-CoA + taurine <=> CoA + H(+) + N-hexadecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57816", "l": "dGMP + H2O = 2-deoxy-D-ribose 5-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45795", "l": "2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 <=> [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69005", "l": "Cdc6 protein is phosphorylated by CDK (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448702", "l": "Caspase-1 active tetramer formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74280", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IVA => a 2-acyl-sn-glycero-3-phosphocholine + a lipid IVB", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46312", "l": "3-oxochol-4-en-22-oyl-CoA + acetyl-CoA = 3,22-dioxochol-4-en-24-oyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018071", "l": "NAD(P)-cysteine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: NAD(P)+ + L-cysteine = nicotinamide + N2-(ADP-D-ribosyl)-L-cysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9648268", "l": "HTR1A binds HTR1A antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132201", "l": "Opsonization with C3b or C4b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035539", "l": "8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity", "d": ["Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30443", "l": "2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc = 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": []}, {"i": "EC:2.3.2.18", "l": "\"N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17519", "l": "a long-chain fatty acid + L-glutamate => H2O + N-(long-chain-fatty-acyl)-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41828", "l": "(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71397", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate(in) => (5Z,8Z,11Z,14Z)-eicosatetraenoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.192", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66093", "l": "3-phenylpyruvate + L-kynurenine => H2O + kynurenate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051474", "l": "glucosylglycerol transmembrane transporter activity", "d": ["Enables the transfer of a glucosylglycerol from one side of a membrane to the other. A glucosylglycerol is an alpha-D-glucopyranosyl-alpha-(1,2)-glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806610", "l": "Keratin filament formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73542", "l": "dCTP(out) + UTP(in) <=> dCTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17679", "l": "2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+) => 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19604", "l": "H(+) + NADH + O2 + orcinol <=> 2,3,5-trihydroxytoluene + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24316", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (+)-copalyl diphosphate", "d": []}, {"i": "EC:5.5.1.12", "l": "\"copalyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10948", "l": "ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14347", "l": "CO2 + tyramine => H(+) + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.5", "l": "\"aldehyde oxygenase (deformylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65939", "l": "beta-D-mannose <=> beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33559", "l": "an acyl-CoA + sn-glycerol 3-phosphate = a 2-acyl-sn-glycerol 3-phosphate + CoA", "d": []}, {"i": "EC:2.3.1.198", "l": "\"glycerol-3-phosphate 2-O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809707", "l": "MTMR12 binds MTMR2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047073", "l": "2,4'-dihydroxyacetophenone dioxygenase activity", "d": ["Catalysis of the reaction: 2,4'-dihydroxyacetophenone + O2 = 4-hydroxybenzoate + formate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759502", "l": "CDH11 nascent mRNA is spliced into the variant splicing isoform (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56152", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine = (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72176", "l": "5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) => 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65215", "l": "(2E)-dodecenoyl-CoA + H2O <=> (2E)-dodecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71624", "l": "malonate(out) + phosphate(in) => malonate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61626", "l": "5-aminopentanal + L-glutamate => 2-oxoglutarate + cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38213", "l": "1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA => hexadecane-1,2-diol + 2 hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106332", "l": "ds/ssDNA junction-specific dsDNA endonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of double-stranded DNA near a double-strand/single-strand DNA junction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9669893", "l": "KIT binds type I TKIs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730967", "l": "STAT1 stimulates SMAD7 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44110", "l": "2 H(+) + heptanoate + NADH => H2O + heptanal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32893", "l": "alpha-pinene oxide + H2O + NAD(+) => (1S,5S)-alpha-pinene + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73851", "l": "27-hydroxywithanone + UDP-alpha-D-glucose = H(+) + UDP + withanone 27-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42535", "l": "uridine(55) in tRNA <=> pseudouridine(55) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64063", "l": "(S)-phenylacetylcarbinol + NAD(+) <=> 1-phenyl-1,2-propanedione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30902", "l": "bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose <=> beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669023", "l": "TWEAK binds FN14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045550", "l": "geranylgeranyl reductase activity", "d": ["Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684008", "l": "NBN binds KPNA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24547", "l": "H2O + L-lysyl-[protein] + O2 <=> (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20671", "l": "4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.151", "l": "\"alkylcobalamin dealkylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3341294", "l": "Superoxide reduces cytochrome c (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71071", "l": "L-arginine(in) + L-cysteine(out) = L-arginine(out) + L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24081", "l": "ATP + L-tryptophan + tRNA(Trp) => AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190829", "l": "Lysosomal degradation of gap junction plaques (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47620", "l": "2-ethylhexyl sulfate + 2-oxoglutarate + O2 = 2-ethylhexanal + CO2 + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.253913141376358", "identifiers": [{"i": "GO:0033558", "l": "protein lysine deacetylase activity", "d": ["Catalysis of the reaction: H2O + N6-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641206", "l": "RSPOs bind LGRs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051433", "l": "BH2 domain binding", "d": ["Binding to a BH2 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070780", "l": "dihydrosphingosine-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: dihydrosphingosine 1-phosphate + H2O = dihydrosphingosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6813749", "l": "ALDH1A1 oxidises GA to DGA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34109", "l": "1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA => glycine + H(+) + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956234", "l": "Translation of DCUN1D3 is inhibited by PUM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0051734", "l": "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: ATP + 5'-dephosphopolynucleotide = ADP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA."]}, {"i": "EC:2.7.1.78", "l": "\"polynucleotide 5'-hydroxyl-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004692", "l": "cGMP-dependent protein kinase activity", "d": ["cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74887", "l": "2',3'-cGAMP(in) + ATP + H2O = 2',3'-cGAMP(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32370", "l": "4 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone <=> 4 Fe(II)-[cytochrome c] + 5 H(+) + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51722", "l": "AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53699", "l": "2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216283", "l": "RDX binds to and ubiquitinates CI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20493", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.244", "l": "\"N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839114", "l": "BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56560", "l": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180555", "l": "Association of APOBEC3G:Vif with the Cul5-SCF complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.72", "l": "\"fibrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928607", "l": "p-EPHs bind VAV2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35574", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] <=> (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863463", "l": "STON2 binds SYT proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432946", "l": "PARVB/Affixin interacts with alpha PIX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61450", "l": "11a-hydroxytigecycline + H2O + NADP(+) => H(+) + NADPH + O2 + tigecycline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29239", "l": "H(+)(in) + uracil(in) = H(+)(out) + uracil(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20538", "l": "H2O + holo-[ACP] => (R)-4'-phosphopantetheine + apo-[ACP] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008938", "l": "nicotinate N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinate = N-methylnicotinate + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22572", "l": "A + H2O + N-methyl-L-glutamate = AH2 + formaldehyde + L-glutamate", "d": []}, {"i": "EC:1.5.99.5", "l": "\"methylglutamate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33272", "l": "a triacyl-sn-glycerol + H2O => a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33367", "l": "D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] = D-glucose 6-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.199", "l": "\"protein-N(pi)-phosphohistidine--D-glucose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61733", "l": "steviol + UDP-alpha-D-glucose => H(+) + steviolmonoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174741", "l": "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35130", "l": "L-alanyl-D-glutamate(out) <=> L-alanyl-D-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69588", "l": "inosine + UMP = IMP + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30228", "l": "dimethyl sulfide + 2 Fe(III)-[cytochrome c2] + H2O => dimethyl sulfoxide + 2 Fe(II)-[cytochrome c2] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30771", "l": "guanosine + H2O = D-ribose + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047373", "l": "acetoxybutynylbithiophene deacetylase activity", "d": ["Catalysis of the reaction: 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674018", "l": "BRAP binds RAS:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848829", "l": "CBL autoubiquitinates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362386", "l": "Glycosylation of Hh (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27663", "l": "(S)-2-hydroxyglutarate + O2 => 2-oxoglutarate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668395", "l": "CHMP7 binds CC2D1B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013158", "l": "CDC42 GDIs block activation of CDC42 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66462", "l": "14betaH-scalarane-17alpha-19-diol => (2E,6E,10E,14E)-geranylfarnesol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182986", "l": "CBL-mediated ubiquitination of CIN85 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35430", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside <=> (E)-sinapate + cyanidin 3,5-di-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29434", "l": "ATP + phosphate <=> ADP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40405", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.68", "l": "\"coniferyl-aldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636297", "l": "PtpA binds TRIM27 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60800", "l": "2-oxoglutarate + gibberellin A53 + O2 = CO2 + gibberellin A44 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.152", "l": "\"hydroperoxy icosatetraenoate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46883", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19395", "l": "(S)-2-amino-6-oxohexanoate + L-alanine => L-lysine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029456", "l": "RAC1 and CDC42 activate PAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186773", "l": "PDGF dimer binds two receptors simultaneously (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25400", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate => (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64534", "l": "an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O => an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31218", "l": "(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) <=> (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754129", "l": "CDK6 inhibitors bind CDK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68564", "l": "6-methoxycoumarin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25508", "l": "(2E)-geranyl diphosphate = (1S,5S)-sabinene + diphosphate", "d": []}, {"i": "EC:4.2.3.109", "l": "\"(-)-sabinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627078", "l": "XIAP binds CASP9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32283", "l": "3-hydroxyanthranilate + O2 = H(+) + H2O + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042605", "l": "peptide antigen binding", "d": ["Binding to an antigen peptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061632", "l": "RNA lariat debranching enzyme activator activity", "d": ["Binds to and increases the activity of an RNA lariat debranching enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72669", "l": "2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + secoxyloganin => O2 + reduced [NADPH--hemoprotein reductase] + secologanin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49205", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59324", "l": "D-xylose + O2 = D-xylono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852010", "l": "BTNL2 binds activated T cells surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61695", "l": "holo-[peptidyl-carrier protein] + L-threonyl-5'-AMP <=> AMP + L-threonyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392530", "l": "p-S400-Cot phosphorylates NIK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72965", "l": "acetoacetate(in) + 2 Na(+)(in) => acetoacetate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40040", "l": "2 ATP + 2 L-glutamate + N-acetyl-L-aspartate => 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0106018", "l": "phosphatidylinositol-3,5-bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849094", "l": "ARHGAP35 binds RASA1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901514", "l": "ATPase-coupled lipo-chitin oligosaccharide transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipo-chitin oligosaccharide(in) = ADP + phosphate + lipo-chitin oligosaccharide(out)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004123", "l": "cystathionine gamma-lyase activity", "d": ["Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047031", "l": "diethyl 2-methyl-3-oxosuccinate reductase activity", "d": ["Catalysis of the reaction: diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP+ = diethyl 2-methyl-3-oxosuccinate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369028", "l": "ABCAs mediate lipid efflux (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49678", "l": "H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+) => H(+) + L-methionyl(47)-[F-actin] + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0043797", "l": "glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59758", "l": "H(+) + N(omega)-methyl-L-arginine + S-adenosyl-L-homocysteine => L-arginine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20841", "l": "H(+) + L-histidine => CO2 + histamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64599", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose <=> an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64073", "l": "acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA => 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23770", "l": "an N-acylsphing-4-enine + CoA + H(+) => a fatty acyl-CoA + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39499", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA = (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12924", "l": "glycine + H(+) + succinyl-CoA <=> 5-aminolevulinate + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42903", "l": "guanosine(745) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41070", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11526", "l": "cholest-4-en-3-one + H(+) + NADPH => 5beta-cholestan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45759", "l": "(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814831", "l": "TBC1D20 binds RAB1:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60651", "l": "an N-(acyl)-sphingosylphosphoethanolamine <=> an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68595", "l": "ORC2 binds ORC3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653936", "l": "Formation of Ragulator complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654571", "l": "Activated FGFR1 binds FRS3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016520", "l": "growth hormone-releasing hormone receptor activity", "d": ["Combining with growth hormone-releasing hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0032453", "l": "histone H3K4 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a modified lysine residue at position 4 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.100", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67488", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35455", "l": "5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2 = (25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26194", "l": "(S)-malate + ATP + CoA => (S)-malyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019976", "l": "interleukin-2 binding", "d": ["Binding to interleukin-2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211193", "l": "Homodimerization  of DFF40 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67986", "l": "N-acetyl-D-leucine => N-acetyl-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814409", "l": "CK2 phosphorylates PDCL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.3.7", "l": "\"3-hydroxymethylcephem carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050237", "l": "pyridoxine 4-oxidase activity", "d": ["Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211164", "l": "AKT phosphorylates FOXO1A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160016", "l": "CCACCA tRNA nucleotidyltransferase activity", "d": ["Catalysis of the reaction: an unstable tRNA + 2 ATP + 4 CTP = a tRNA with a 3' CCACCA end + 6 diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29564", "l": "ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24206", "l": "phosphate + sulfoacetaldehyde => acetyl phosphate + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102903", "l": "gamma-terpinene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = gamma-terpinene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-844438", "l": "NLRP1 oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5604929", "l": "Activated protein C binds Protein S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51736", "l": "L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75474", "l": "thiamine diphosphate(out) <=> thiamine diphosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2545196", "l": "FN1 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20318", "l": "L-proline + NADP(+) => 1-pyrroline-2-carboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18790", "l": "D-glucosamine 6-phosphate => D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388468", "l": "AVP(20-28) binds AVPR1A,B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31890", "l": "(S)-2,3-epoxysqualene <=> tirucalladienol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75252", "l": "carminate + O2 => 3'-dehydrocarminate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66189", "l": "3',5'-cyclic GMP(in) + ATP + H2O => 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634850", "l": "NPAS4 binds ARNT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196857", "l": "PANK2 phosphorylates PanK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72335", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + syringate = 3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004604", "l": "phosphoadenylyl-sulfate reductase (thioredoxin) activity", "d": ["Catalysis of the reaction: adenosine 3',5'-diphosphate + H+ + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14427", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420233", "l": "VIP receptors bind VIP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49061", "l": "a long-chain alkane + FMNH2 + O2 => a long chain fatty alcohol + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5591052", "l": "PROCR binds Protein C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28776", "l": "dinoflagellate luciferin + O2 => H(+) + H2O + hnu + oxidized dinoflagellate luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56733", "l": "4,4-dihydroxy-all-trans-beta-carotene => echinenone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70129", "l": "3-dehydro-6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36103", "l": "anthranilate + S-adenosyl-L-methionine = O-methyl anthranilate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.277", "l": "\"anthranilate O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21228", "l": "alpha-maltose = beta-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102068", "l": "alpha-humulene 10-hydroxylase activity", "d": ["Catalysis of the reaction: (1E,4E,8E)-alpha-humulene + NADPH + O2 + H+ <=> 10-hydroxy-alpha-humulene + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62091", "l": "D-glucosamine 6-phosphate + NADP(+) <=> 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.13", "l": "\"succinate--hydroxymethylglutarate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427570", "l": "Group 3 - Selective Cl- transport (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63720", "l": "losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623643", "l": "RDH13 reduces atRAL to atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48629", "l": "a ribonucleotide in rRNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18196", "l": "H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] <=> (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65443", "l": "a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928597", "l": "EPH:EFN dimers tetramerise (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48230", "l": "a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] => a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9613497", "l": "Unwinding DNA for the nascent transcript (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58627", "l": "N-dodecanoyl-(2S)-hydroxyglycine <=> dodecanamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57973", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685230", "l": "CHEK1 phosphorylates RAD51 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12928", "l": "D-erythrose 4-phosphate + L-lysyl-[protein] <=> H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5144542", "l": "CLOCK acetylates lysine-15 of histone H3, H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59823", "l": "2 ATP <=> adenosine 3'-diphosphate,5'-triphosphate + AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22172", "l": "beta-D-fructose 6-phosphate + UDP-alpha-D-glucose = H(+) + sucrose 6(F)-phosphate + UDP", "d": []}, {"i": "EC:2.4.1.14", "l": "\"sucrose-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18857", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.138", "l": "\"lithocholate 6beta-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198314", "l": "DAG stimulates protein kinase C-delta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39857", "l": "a triacyl-sn-glycerol + glycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50306", "l": "21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16065", "l": "2-oxoglutarate + O2 + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.18", "l": "\"phytanoyl-CoA dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928576", "l": "RHOA:GTP binds ROCK, activating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140806", "l": "SERPINC1 binds SERPINC1 activators (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004875", "l": "complement receptor activity", "d": ["Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63966", "l": "(2E,12Z)-hexadecadienal + phosphoethanolamine => sphinga-4E,14Z-dienine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.114", "l": "\"equine arterivirus serine peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28476", "l": "D-glucarate(out) + H(+)(out) => D-glucarate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44285", "l": "2 H(+) + 2 malonyl-CoA + octanoyl-CoA => 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.131", "l": "\"carotenoid 1,2-hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49049", "l": "25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805126", "l": "AURKB phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693148", "l": "BCKDK phosphorylates BCKDH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140070", "l": "hydrogen peroxide channel activity", "d": ["Enables the transfer of hydrogen peroxide from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9655086", "l": "ATF4 binds the DDIT3 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.159", "l": "\"inositol-1,3,4-trisphosphate 5/6-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72905", "l": "butyrolactone I + diphosphate => butyrolactone II + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37263", "l": "ATP + H2O + L-alanyl-L-aspartate(out) = ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169719", "l": "Secreted CD14 binds LPS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879674", "l": "CD97 binds CD55 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694583", "l": "ABHD4 hydrolyses NAPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36084", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936731", "l": "Inactive BRAF mutants:mutant RAS:GTP bind RAF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0015234", "l": "thiamine transmembrane transporter activity", "d": ["Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13840", "l": "cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) <=> 4,5-dihydroxyphthalate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987223", "l": "IL10RB binds TYK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.36", "l": "\"acetoacetyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46026", "l": "(3R)-hydroxytetradecanoate + H2O => H2O2 + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57083", "l": "glutathione + S-methyl-1-thio-D-xylulose 5-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2025890", "l": "Calcineurin binds NFATC1,2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16202", "l": "4-amino-4-deoxychorismate => 4-aminobenzoate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.73", "l": "\"albendazole monooxygenase (sufoxide-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64970", "l": "dUDP + H(+) + phosphate => dUTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55114", "l": "(3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+) => 4-methyl-3-oxopentanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1006143", "l": "CD46 binds C3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0005220", "l": "inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944232", "l": "Association of procollagen type XII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53878", "l": "ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate => a cytidine in tRNA + acetyl-CoA + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12716", "l": "a nucleoside 5'-phosphate + ATP <=> a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49156", "l": "dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine = dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797090", "l": "CCNK binds CDK12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864577", "l": "TFAP2C translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42259", "l": "H(+) + hexanoyl-CoA + malonyl-[ACP] <=> 3-oxooctanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39559", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA = (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186786", "l": "Autophosphorylation of PDGF beta receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701548", "l": "PRDM1 gene expression downstream of ALK signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18238", "l": "2,5-dihydroxybenzoate + O2 => 3-maleylpyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59227", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + hydropyrene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048487", "l": "beta-tubulin binding", "d": ["Binding to the microtubule constituent protein beta-tubulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35077", "l": "doxorubicin(out) + H(+)(in) => doxorubicin(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047895", "l": "formaldehyde dismutase activity", "d": ["Catalysis of the reaction: 2 formaldehyde + H2O = methanol + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63118", "l": "nitrate => peroxynitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25179", "l": "3-methylbutanoyl-CoA + CO2 + NADH => 4-methyl-2-oxopentanoate + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691150", "l": "TFR2 dimer binds 2xholoTF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12746", "l": "a 1,4-lactone + H2O => a 4-hydroxyacid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0000510", "l": "H3-H4 histone complex chaperone activity", "d": ["A histone chaperone that carries a H3-H4 histone complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11290", "l": "H2O2 + macarpine => dihydromacarpine + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65819", "l": "AH2 + ATP + 2 Co(II)-[methylamine-specific corrinoid protein] + H2O <=> A + ADP + 2 Co(I)-[methylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692408", "l": "NPR2 binds NPPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73285", "l": "H(+)(in) + L-isoleucine(out) => H(+)(out) + L-isoleucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699163", "l": "Defective BARD1 does not bind BRCA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45362", "l": "(11Z)-eicosenoate + sphinganine => H2O + N-(11Z-eicosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855168", "l": "I(1,3,4,5)P4 transports from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9714580", "l": "SLC6A3 binds DRIs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60325", "l": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048472", "l": "threonine-phosphate decarboxylase activity", "d": ["Catalysis of the reaction: O-phospho-L-threonine + H+ = (R)-1-aminopropan-2-yl phosphate + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019962", "l": "type I interferon binding", "d": ["Binding to a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35269", "l": "ethanol(out) => ethanol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66278", "l": "H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP => tigogenin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75306", "l": "NAD(+) <=> 3'cADPR + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810643", "l": "EPPIN protein complex binds bacteria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15195", "l": "2'-deoxyguanosine + H(+) + triphosphate => dGTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013006", "l": "RHOA:GTP translocates to the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381727", "l": "RAP1A exchanges GDP for GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419645", "l": "Dimerization of LIMK1 by Hsp90 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944242", "l": "Association of procollagen type XXVII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676589", "l": "RANKL,sRANKL trimer binds RANK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23745", "l": "2-oxoglutarate + L-histidinol phosphate => 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69469", "l": "2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose => L-glutamate + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44884", "l": "a cardiolipin + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102049", "l": "indole-3-acetyl-methionine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-methionine + ATP(4-) <=> H+ + indole-3-acetyl-methionine + AMP(2-) + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433506", "l": "Phosphorylation of APS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17432", "l": "NAD(+) + trans-4-hydroxycyclohexanecarboxylate <=> 4-oxocyclohexanecarboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072346", "l": "cADPR-sensitive calcium-release channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens when cyclic adenosine diphosphate ribose (cADPR) has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38343", "l": "(20S)-ginsenoside Rd + H2O = (20S)-ginsenoside Rg3 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664850", "l": "ATM binds PEX5 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57354", "l": "H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853496", "l": "SCF:FBXL7 binds AURKA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20178", "l": "pyridoxine + UDP-alpha-D-glucose => 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975633", "l": "atROL binds to RBP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614185", "l": "Mg2+ binds GRIN1:GRIN2 NMDA receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0031714", "l": "C5a anaphylatoxin chemotactic receptor binding", "d": ["Binding to a C5a anaphylatoxin chemotactic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010648", "l": "ROBO2 binds AKAP5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70953", "l": "3-hydroxypyruvate + H2O2 + NH4(+) => D-serine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36562", "l": "A + cis-4-hydroxy-D-proline <=> 4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114352", "l": "Sequestration of tBID by BCL-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54268", "l": "2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 = (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.30", "l": "\"hypoxia-inducible factor-asparagine dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730767", "l": "Monofunctional chemotherapeutic alkylating drugs produce 7-methylguanine in dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58407", "l": "hexan-1-ol + NADP(+) <=> H(+) + hexanal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10066", "l": "(6S)-5,6,7,8-tetrahydrofolate + 2-methylserine => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660663", "l": "Caspase-8 cleaves IL1B precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2691214", "l": "NOTCH1 HD domain mutants bind JAG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682544", "l": "nsp14 binds nsp10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196753", "l": "2xPPCS ligates PPanK with Cys (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48072", "l": "ganglioside GM1 (d18:1(4E)) + H2O = ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2152276", "l": "Secretion of transmembrane collagens (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420265", "l": "AMY1-3 bind IAPP(34-70) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43025", "l": "an S-substituted L-cysteine => 2-aminoprop-2-enoate + a thiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73430", "l": "genkwanin + O2 + reduced [NADPH--hemoprotein reductase] <=> H2O + oxidized [NADPH--hemoprotein reductase] + scutellarein 7-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183055", "l": "Binding of CBL to EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17940", "l": "dihydroxyacetone phosphate <=> methylglyoxal + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050081", "l": "maltose-6'-phosphate glucosidase activity", "d": ["Catalysis of the reaction: H2O + maltose 6'-phosphate = D-glucose + D-glucose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873850", "l": "STARD5 binds DCA, LCA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53786", "l": "beta-muricholoyl-CoA + deoxycholate => beta-muricholate + deoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43410", "l": "beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP => sphinganine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56920", "l": "a medium chain fatty acid + ATP + H(+) = a medium-chain fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22737", "l": "5-formimidoyltetrahydrofolate + 2 H(+) => 5,10-methenyltetrahydrofolate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42823", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 <=> H2O + 2 NADP(+) + tetracenomycin C", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018496", "l": "2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2,6-dihydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952996", "l": "E2F7 forms homodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42918", "l": "2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0030731", "l": "guanidinoacetate N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709547", "l": "ESTG binds ESR2:chaperone complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34394", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose <=> [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851888", "l": "MET binds SHC1-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102727", "l": "3beta-hydroxysteroid dehydrogenase activity", "d": ["Catalysis of the reaction: campest-4-en-3beta-ol + NAD = campest-4-en-3-one + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39137", "l": "(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2 => (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22857", "l": "(7S)-salutaridinol + acetyl-CoA => (7S)-O-acetylsalutaridinol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33495", "l": "all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate = 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.n9", "l": "\"heptaprenylglyceryl phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043682", "l": "P-type divalent copper transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) -> ADP + phosphate + Cu2+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050208", "l": "polysialic-acid O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193695", "l": "IRAK interacts with TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36955", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA = (9Z)-pentadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811412", "l": "Active ARF recruits coatomer to the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047554", "l": "2-pyrone-4,6-dicarboxylate lactonase activity", "d": ["Catalysis of the reaction: 2-oxo-2H-pyran-4,6-dicarboxylate + H2O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19700", "l": "11-cis-retinyl hexadecanoate + H2O <=> 11-cis-retinol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706364", "l": "Internalization of ubiquitinated FLT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168445", "l": "PTP1B binds the GH receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139895", "l": "tBID activates BAK protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340124", "l": "CSN polymer binds CaPO4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31056", "l": "estrone 3-sulfate + H2O => estrone + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27833", "l": "neryl diphosphate <=> beta-phellandrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58381", "l": "NADP(+) + nonan-1-ol => H(+) + NADPH + nonanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53279", "l": "17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72662", "l": "NADPH + O2 + quinolin-8-ol <=> 8-hydroxyquinoline N-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10316", "l": "2-oxoglutarate + O2 + thymine = 5-hydroxymethyluracil + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.6", "l": "\"thymine dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043274", "l": "phospholipase binding", "d": ["Binding to a phospholipase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51213", "l": "(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) => 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781899", "l": "USP13 binds SIAH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451418", "l": "Pellino ubiquitinates IRAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38021", "l": "1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-decanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63393", "l": "A + Fe(II)-heme o + H2O => AH2 + Fe(II)-heme i", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11941", "l": "2 H(+) + H2O + L-citrulline => CO2 + L-ornithine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55790", "l": "H2O + hydroxyacetone + NAD(+) => acetone + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31963", "l": "9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.322", "l": "\"(-)-endo-fenchol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.3", "l": "\"metridin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74973", "l": "L-leucine(in) + L-lysine(out) + Na(+)(in) => L-leucine(out) + L-lysine(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48773", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a => 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322431", "l": "XIAP binds TLE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102292", "l": "30-hydroxy-beta-amyrin 11-hydroxylase activity", "d": ["Catalysis of the reaction: 30-hydroxy-beta-amyrin + O2 + NADPH + H+ <=> 11alpha,30-dihydroxy-beta-amyrin + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714580", "l": "SLC6A3 binds DRIs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43257", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63947", "l": "a fatty acyl-CoA + sphinga-4E,14Z-dienine <=> an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73325", "l": "cimicifugate D + CoA => (2R,3S)-piscidate + (E)-caffeoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.36", "l": "\"leishmanolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610735", "l": "NUMB binds ITCH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65538", "l": "H(+) + S-adenosyl-L-homocysteine + theacrine => 1,3,7-trimethylurate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50376", "l": "a ceramide(in) + ATP + H2O = a ceramide(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24780", "l": "C-13(2)-carboxypyropheophorbide a + H(+) = CO2 + pyropheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25777", "l": "scyllo-inosose => scyllo-inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63305", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17449", "l": "(2E)-geranyl diphosphate + flaviolin = 3-linalylflaviolin + diphosphate", "d": []}, {"i": "EC:2.5.1.123", "l": "\"flaviolin linalyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36180", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-choline => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44023", "l": "H2O + NAD(+) + octadecanal <=> 2 H(+) + NADH + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54778", "l": "[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+) => 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480685", "l": "POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32553", "l": "(S)-alpha-terpineol + diphosphate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018833", "l": "DDT-dehydrochlorinase activity", "d": ["Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35440", "l": "CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine => archaetidylserine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654625", "l": "Activated FGFR3 binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74730", "l": "Insulin degradation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621010", "l": "HOXB1 activates HOXA2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008390", "l": "testosterone 16-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: testosterone + donor-H2 + O2 = 16-alpha-hydroxytestosterone + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37613", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66137", "l": "acetyl-CoA + tyramine => CoA + H(+) + N-acetyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65963", "l": "ATP + H2O + leukotriene C4(out) <=> ADP + H(+) + leukotriene C4(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75873", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => (6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140929", "l": "mannose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-mannose(out) + Na+(out) = D-mannose(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43409", "l": "sphinganine + UDP-alpha-D-galactose => beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624131", "l": "UNC119B binds myristoylated proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50810", "l": "prostaglandin J2-S-(S)-glutathione => glutathione + prostaglandin J2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9625482", "l": "PTK2 binds activated EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3828025", "l": "DCN (decorin) degradation by MMP14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954117", "l": "E2F6:TFDP1 binds EPC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53468", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32864", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112437", "l": "Formation of NELF complex  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58833", "l": "24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52838", "l": "H2O + indoxyl + NAD(+) => H(+) + indole + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420128", "l": "SRC-1 phosphorylates SHB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73492", "l": "Co(2+)(out) + 2 hydrogencarbonate(out) => Co(2+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35225", "l": "2-oxo-dAMP + H(+) + phosphate => 2-oxo-dADP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23059", "l": "urea <=> cyanamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.21", "l": "\"inositol-hexakisphosphate 5-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74987", "l": "erythrostominone(in) = erythrostominone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28525", "l": "D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O <=> D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39768", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72459", "l": "fumarate(in) + L-aspartate(out) = fumarate(out) + L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34239", "l": "L-glutamate = 3-aminopentanedioate", "d": []}, {"i": "EC:5.4.3.9", "l": "\"glutamate 2,3-aminomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56327", "l": "(2'-deoxyribonucleoside 5'-methylphosphotriester)-DNA + L-cysteinyl-[protein] <=> 2'-deoxyribonucleotide-DNA + H(+) + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69737", "l": "2-phenylsuccinyl-CoA + succinate => phenylsuccinate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678920", "l": "TLR processing at low pH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102560", "l": "5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1-phosphohydrolase activity", "d": ["Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O <=> D-ribofuranose 2,5-bisphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660840", "l": "Defective SLC6A5 does not cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44363", "l": "(2S)-2-hydroxy-3,4-dioxopentyl phosphate <=> 3-hydroxy-2,4-dioxopentyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849085", "l": "ARHGAP35 binds RHOA:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21645", "l": "ATP + glycerol => ADP + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035949", "l": "Defective B4GALT1 does not transfer Gal to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021050", "l": "HSBP1 oligomer binds ESRs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69553", "l": "dihydroxyacetone phosphate + L-glutamate => (S)-serinol phosphate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0004457", "l": "lactate dehydrogenase activity", "d": ["Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59883", "l": "4-hydroxyphenylacetate + FMNH2 + O2 <=> 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17137", "l": "prostaglandin H2 = thromboxane A2", "d": []}, {"i": "EC:5.3.99.5", "l": "\"thromboxane-A synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64577", "l": "2 Fe(III)-[cytochrome b5] + NADPH => 2 Fe(II)-[cytochrome b5] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48654", "l": "20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19873", "l": "dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.2", "l": "\"steryl-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050522", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP."]}, {"i": "EC:1.20.98.-", "l": "\"With other, known acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876484", "l": "NPC2 transfers CHOL to NPC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483219", "l": "PC is exchanged with PI by PITPNB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11279", "l": "4 hydroquinone + O2 <=> 4 benzosemiquinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20970", "l": "2-dehydro-3-deoxy-L-arabinonate + H2O => L-arabinonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18289", "l": "(S,S)-tartrate = H2O + oxaloacetate", "d": []}, {"i": "EC:4.2.1.81", "l": "\"D(-)-tartrate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57081", "l": "glutathione + S-methyl-1-thio-D-xylulose 5-phosphate => 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27541", "l": "ethanol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18160", "l": "ATP + pyruvate <=> ADP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.91", "l": "\"7-methylguanosine nucleotidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034907", "l": "acetanilide 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: acetanilide + O2 + 2 H+ + NADH = catechol + NAD+ + acetamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420688", "l": "GABAB heterodimeric receptor binds GABA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202248", "l": "Phosphorylation of PLC-gamma1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36908", "l": "(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA => (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051907", "l": "S-(hydroxymethyl)glutathione synthase activity", "d": ["Catalysis of the reaction: S-(hydroxymethyl)glutathione = formaldehyde + glutathione."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0051916", "l": "granulocyte colony-stimulating factor binding", "d": ["Binding to granulocyte colony-stimulating factor, G-CSF."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334788", "l": "CUTC binds Cu+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12325", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine => L-asparagine + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033592", "l": "RNA strand annealing activity", "d": ["An activity that facilitates the formation of a complementary double-stranded RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25033", "l": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.300", "l": "\"NADP-retinol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164845", "l": "Suicidal integration leading to inverted circle formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578777", "l": "DMPK phosphorylates PLN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875816", "l": "STAT3 binds activated MET receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67527", "l": "4,8-dimethylnonanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44552", "l": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O = H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23301", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate => (2Z,6E)-farnesyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032323", "l": "oxo-DPAn-3s translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862184", "l": "USP48 cleaves polyubiquitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-167415", "l": "G-protein alpha subunit is inactivated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62902", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+) => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47077", "l": "17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH => 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68115", "l": "H2O + propanamide <=> NH4(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21340", "l": "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 = 2 vanillin", "d": []}, {"i": "EC:1.13.11.43", "l": "\"lignostilbene alphabeta-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102002", "l": "valine N-monooxygenase (oxime forming) activity", "d": ["Catalysis of the reaction: L-valine + 2 O2 + 2 NADPH(4-) + 2 H+ <=> (E)-2-methylpropanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14622", "l": "(S)-2,3-epoxysqualene => lanosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14547", "l": "NH4(+) + nicotinate => H2O + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043546", "l": "molybdopterin cofactor binding", "d": ["Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10573", "l": "vinylacetyl-CoA => (2E)-butenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34653", "l": "3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine => 3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211164", "l": "AKT phosphorylates FOXO1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39342", "l": "(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68611", "l": "Formation of ORC(1-5) complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44000", "l": "2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 = 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11674", "l": "4-amino-4-deoxychorismate + L-glutamate => chorismate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66586", "l": "25-hydroxy 3-oxocholestane + AH2 => 3-oxocholestane + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419428", "l": "S1PR2-5 bind S1P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39522", "l": "3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186780", "l": "PI3-kinase binds to the active receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33708", "l": "ATP + L-threonine => ADP + H(+) + O-phospho-L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28890", "l": "H(+)(in) + L-serine(in) <=> H(+)(out) + L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41191", "l": "1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75949", "l": "L-ornithine + taurocyamine => L-arginine + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419049", "l": "ROCK activation by RHO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46591", "l": "calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcidiol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18124", "l": "an S-substituted L-cysteine + H2O <=> a thiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749197", "l": "ORC1 binds to H4K20me2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27350", "l": "arsenate + mycothiol => arseno-mycothiol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322427", "l": "Beta-catenin recruits CBP/p300 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55403", "l": "7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) <=> archaeosine(15) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416683", "l": "SEMA3E binds to PLXND1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446077", "l": "BP230 interacts with keretin K5/K14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47994", "l": "H(+)(out) + NADH + NADP(+) => H(+)(in) + NAD(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67635", "l": "a plastoquinone + 6 H(+)(in) + 2 reduced [2Fe-2S]-[ferredoxin] <=> a plastoquinol + 4 H(+)(out) + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41106", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33824", "l": "3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH => NAD(+) + tetrahydro-4-hydroxyphenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072548", "l": "dicoumaroyl monocaffeoyl spermidine meta-hydroxylase activity", "d": ["Catalysis of the reaction: dicoumaroyl monocaffeoyl spermidine + NADPH + O2 = monocoumaroyl dicaffeoyl spermidine + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57757", "l": "2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH => C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391933", "l": "EP3 receptor can bind PGE2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42677", "l": "L-cysteine + L-histidine + O2 => H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63478", "l": "15-oxoprostaglandin E2 + H(+) + NADPH => NADP(+) + prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.523519163150823", "identifiers": [{"i": "GO:0046527", "l": "glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003831", "l": "beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876446", "l": "p-ULK1 phosphorylates DENND3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11382", "l": "[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate => 2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928627", "l": "EPHB phosphorylates TIAM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72541", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADPH => 3,4-dihydroxybenzaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690873", "l": "ACO1 binds 4Fe-4S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9678925", "l": "NR3C1 binds NR3C1 agonists (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168923", "l": "Collagen type XVIII endostatin release (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928620", "l": "PAK1 autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31236", "l": "(4S)-4-hydroxy-L-glutamate + 2-oxoglutarate => (4R)-4-hydroxy-2-oxoglutarate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64094", "l": "3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+) => 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54638", "l": "diphosphate + labda-7,13(16),14-triene => (13E)-labda-7,13-dien-15-yl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69186", "l": "diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102142", "l": "[dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [dermatan]-alpha-L-iduronate <=> adenosine 3',5'-bismonophosphate + [dermatan-sulfate]-2-O-sulfo-alpha-L-iduronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64181", "l": "an N-(fatty acyl)-L-tryptophan + H2O => a fatty acid + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31614", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene <=> H2O + rhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49328", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene = 2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.3.6", "l": "\"farnesylcysteine lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42194", "l": "(9Z,12Z)-pentadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-pentadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68786", "l": "diphosphate + gamma-curcumene => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62941", "l": "H2O + N(4)-acetylcytosine => acetate + cytosine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0140940", "l": "histone H2A methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a histone H2 = S-adenosyl-L-homocysteine + a methylated histone H2A. Histone methylation generally occurs on either an arginine or a lysine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848316", "l": "IL36 binds IL1RL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28910", "l": "3-(3-hydroxyphenyl)propanoate(in) + H(+)(in) <=> 3-(3-hydroxyphenyl)propanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937177", "l": "AHR:TCDD binds ARNT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21928", "l": "3-dehydro-L-gulonate + NADP(+) = 2,3-dioxo-L-gulonate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74686", "l": "2 AH2 + 2 archaeol + 4 S-adenosyl-L-methionine <=> 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether + 4 H(+) + 4 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804955", "l": "ATM phosphorylates MDM2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250264", "l": "TXNIP binds reduced thioredoxin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031816", "l": "P2Y6 nucleotide receptor binding", "d": ["Binding to a P2Y6 nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10241", "l": "a 2,3-saturated acyl-[ACP] + NAD(+) => a (2E)-enoyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30507", "l": "2-demethylmenaquinone-8 + H(+) + NADH = 2-demethylmenaquinol-8 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15378", "l": "(S)-4,5-dihydroxypentane-2,3-dione + ATP => (2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607721", "l": "Activation of NIK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12158", "l": "2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH => 2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53618", "l": "(+)-isoafricanol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29245", "l": "menaquinol-8 + NAD(+) => H(+) + menaquinone-8 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49249", "l": "galactitol(out) + N(pros)-phospho-L-histidyl-[protein] => galactitol 1-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45817", "l": "(S)-lactate + A => AH2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350436", "l": "DGO binds to DSH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.330199557084356", "identifiers": [{"i": "GO:0015269", "l": "calcium-activated potassium channel activity", "d": ["Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56882", "l": "a 3-oxo-Delta(5)-steroid + H(+) + NADPH => a 3beta-hydroxy-Delta(5)-steroid + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19779", "l": "AH2 + H(+) + L-1-piperideine-6-carboxylate => A + L-pipecolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734475", "l": "PPARA binds fibrates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23077", "l": "4-chlorobenzoyl-CoA + chloride + NADP(+) => 2,4-dichlorobenzoyl-CoA + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851298", "l": "GPR143 binds L-Dopa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34792", "l": "2-hydroxyethylphosphonate + O2 => formate + H(+) + hydroxymethylphosphonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20928", "l": "[DsbA protein]-dithiol + a quinone = [DsbA protein]-disulfide + a quinol", "d": []}, {"i": "EC:1.8.5.9", "l": "\"protein dithiol:quinone oxidoreductase DsbB\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.109", "l": "\"sphingomyelin deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71372", "l": "epitestosterone 17-sulfate(out) + 2 Na(+)(out) => epitestosterone 17-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23696", "l": "myo-inositol + O2 = D-glucuronate + H(+) + H2O", "d": []}, {"i": "EC:1.13.99.1", "l": "\"inositol oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35140", "l": "(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O => CO2 + 2 CoA + demethoxycurcumin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71254", "l": "L-xylopyranose <=> L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5252133", "l": "ATP6AP1 binds V-ATPase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.062480095235458", "identifiers": [{"i": "GO:0004536", "l": "DNA nuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39243", "l": "(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65267", "l": "3-hydroxypentacecilide A + A <=> AH2 + chrodrimanin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018121", "l": "NAD(P)-asparagine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: NAD(P)+ + L-asparagine = nicotinamide + N2-(ADP-D-ribosyl)-L-asparagine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700149", "l": "Active ALK binds PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875183", "l": "CBL monoubiquitinates activated MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18985", "l": "chorismate = isochorismate", "d": []}, {"i": "EC:5.4.4.2", "l": "\"isochorismate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685608", "l": "CLEC2B binds KLRF1 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809521", "l": "BPIF binds bacteria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49100", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine = 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036185", "l": "13-lipoxin reductase activity", "d": ["Definition: Catalysis of the reaction: 15-oxolipoxin A4 + NAD(P)H + H+ = 13,14-dihydro-15-oxolipoxin A4 + NAD(P)+."]}, {"i": "REACT:R-HSA-2161844", "l": "15k-LXA4 is reduced to dhk-LXA4 by PTGR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047356", "l": "CDP-ribitol ribitolphosphotransferase activity", "d": ["Catalysis of the reaction: ribitol phosphate(n) + CDP-ribitol = ribitol phosphate(n+1) + CMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31978", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin <=> 7beta-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68902", "l": "4-methoxybenzaldehyde + AMP + diphosphate + NADP(+) => 4-methoxybenzoate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534365", "l": "Slo3 Potassium Transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332235", "l": "CBL binds TGFBR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40166", "l": "D-glyceraldehyde + H2O + NADP(+) <=> (R)-glycerate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60558", "l": "pseudouridine(35) in tRNA(Tyr) => uridine(35) in tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36582", "l": "dTDP-alpha-D-fucose + NAD(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47430", "l": "3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28380", "l": "ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine => ATP + N(6)-(D-fructosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33381", "l": "(4R)-hydroxyeicosasphinganine + phosphate => 4-hydroxyeicosasphinganine 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54062", "l": "(2Z,6E)-hedycaryol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54783", "l": "[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine <=> [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46651", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA <=> androst-4-ene-3,17-dione + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24043", "l": "NADPH + 2 oxidized [cytochrome P450] <=> H(+) + NADP(+) + 2 reduced [cytochrome P450]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47177", "l": "(2R)-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202731", "l": "JAM3 dimerises (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66498", "l": "alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54516", "l": "8-hydroxycopalyl diphosphate = (13R)-manoyl oxide + diphosphate", "d": []}, {"i": "EC:4.2.3.190", "l": "\"manoyl oxide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57059", "l": "D-apiofuranose + NAD(+) <=> D-apionolactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029149", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48817", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 => 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40113", "l": "butanoate + CoA + H(+) => butanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9650858", "l": "Meglitinides bind ABCC8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134914", "l": "Beta-catenin migrates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23311", "l": "(E)-sinapoyl-CoA + D-glucarate <=> 2-O-[(E)-sinapoyl]-D-glucarate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37001", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54371", "l": "acetaldehyde + H(+) + pyruvate <=> acetoin + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296244", "l": "SUCNR1 binds SUCCA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41195", "l": "1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35382", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA <=> (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008883", "l": "glutamyl-tRNA reductase activity", "d": ["Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68128", "l": "a fatty acyl-CoA + phytol = a fatty acid phytyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41136", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061663", "l": "NEDD8 ligase activity", "d": ["Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S = X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate."]}, {"i": "EC:2.3.2.32", "l": "\"cullin-RING-type E3 NEDD8 transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48276", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982637", "l": "Opsins binds G alpha-t (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43882", "l": "(25S)-3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate => (25S)-3beta-hydroxy-5-cholestenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0032404", "l": "mismatch repair complex binding", "d": ["Binding to a mismatch repair complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726509", "l": "NR3C2 binds fludrocortisone (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44183", "l": "2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942302", "l": "MMP13 cleaves OPTC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54611", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67214", "l": "(2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O2 => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21016", "l": "H2O + L-asparagine = L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956427", "l": "RETSAT reduces atROL to at-13,14-dhROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40991", "l": "(E)-4-coumaroyl-CoA + H2O = 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75521", "l": "(R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMN + H(+) + H2O => FMNH2 + N-acetyl-S-benzyl-L-cysteine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804762", "l": "TP53 forms homotetramers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72546", "l": "2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out) <=> 2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5334827", "l": "SUMO-CRABP2 binds atRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53939", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 <=> 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30191", "l": "15-cis-phytoene + plastoquinone-9 = 15,9'-di-cis-phytofluene + plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939054", "l": "RUNX1 binds the PRKCB gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34736", "l": "a fatty acyl-CoA + sphinganine => an N-acylsphinganine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877620", "l": "ECE2 cleaves EDN1(53-90) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19091", "l": "H(+) + precorrin-1 + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uroporphyrinogen III", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097007", "l": "4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity", "d": ["Catalysis of the reaction: (EE)-geranyllinalool + NADPH + O2 = 4,8,12-trimethyl-1,3,7,11-tridecatetraene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C18-farnesylacetone and then cleaved to produce 4,8,12-trimethyl-1,3,7,11-tridecatetraene (TMTT) and acetone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018764", "l": "N-isopropylammelide isopropylaminohydrolase activity", "d": ["Catalysis of the reaction: N-isopropylammelide + H2O = cyanuric acid + isopropylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112042", "l": "Opioid binds MOR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454916", "l": "The ABCC family mediates organic anion transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29229", "l": "H(+)(out) + indole(out) => H(+)(in) + indole(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24813", "l": "2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14295", "l": "D-glucono-1,5-lactone + H(+) + NADH => D-glucose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437118", "l": "GPVI stimulates PI3K beta, gamma (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16356", "l": "2-oxoglutarate + taurine <=> L-glutamate + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202394", "l": "Translocation of CARMA1 to Plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52228", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 = 3 A + biliverdin beta + CO + Fe(2+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419389", "l": "LPA-binding receptors bind LPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53178", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67130", "l": "(1R,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+) => 5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43575", "l": "A + D-arginine + H2O <=> 5-guanidino-2-oxopentanoate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467811", "l": "Separation of sister chromatids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433395", "l": "Dimerization of sSCF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34804", "l": "2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA => bisdemethoxycurcumin + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654571", "l": "Activated FGFR1 binds FRS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212352", "l": "Formation of ARC coactivator complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44677", "l": "a triacyl-sn-glycerol + all-trans-retinol => a diacylglycerol + an all-trans-retinyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75651", "l": "(10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate = 12,13-epoxy-(10R)-hydroxy-(8E,15Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033474", "l": "FGFR2b mutants bind an expanded range of ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15004", "l": "keto-L-sorbose + NADP(+) <=> 5-dehydro-D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33519", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphinganine = (4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0034325", "l": "O-decanoyltransferase activity", "d": ["Catalysis of the transfer of a decyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8963915", "l": "1,25(OH)2D binds VDR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42747", "l": "guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676599", "l": "sBAFF trimer binds BAFFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66328", "l": "taurine(out) = taurine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247836", "l": "Retromer recycles WLS to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59672", "l": "D-maltotriose + O2 = D-maltotriono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015046", "l": "rubredoxin-NADP+ reductase activity", "d": ["Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043960", "l": "L-erythro-3-methylmalyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: L-erythro-3-methylmalyl-CoA = mesaconyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592436", "l": "Initial activation of proMMP9 by MMPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67767", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59742", "l": "CoA + S-octadecanoyl-L-cysteinyl-[protein] => L-cysteinyl-[protein] + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51315", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine <=> H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797553", "l": "Protein 4.1 binds CASK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497878", "l": "Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67570", "l": "adenosine 3',5'-bisphosphate + H(+) + taurochenodeoxycholate 7-sulfate => 3'-phosphoadenylyl sulfate + taurochenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362386", "l": "Glycosylation of Hh (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70582", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047965", "l": "glycoprotein O-fatty-acyltransferase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + mucus glycoprotein = CoA + O-palmitoylglycoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36744", "l": "heptadecasphing-4-enine + tetracosenoyl-CoA => CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70195", "l": "ATP + deamido-NAD(+) = ADP + H(+) + nicotinate-adenine dinucleotide 3'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38801", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36964", "l": "(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983147", "l": "Release of E3 from polyubiquitinated substrate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67509", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-sn-glycero-3-phosphocholine => 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12677", "l": "AH2 + Latia luciferin + 2 O2 = A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin", "d": []}, {"i": "EC:1.14.99.21", "l": "\"Latia-luciferin monooxygenase (demethylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12233", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) => [thioredoxin]-dithiol + glycine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37986", "l": "gamma-tocopherol <=> 2,3-dimethyl-6-phytylbenzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34906", "l": "4 glutathione + 2 H(+) + selenite <=> glutathione disulfide + 3 H2O + selenodiglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47840", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine = (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate", "d": []}, {"i": "EC:2.5.1.131", "l": "\"(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062045", "l": "L-lysine alpha-aminotransferase", "d": ["Catalysis of the reaction: L-lysine + pyruvate= epsilon-amino-alpha-ketocaproic acid (KAC) + alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380782", "l": "STAT binds to the active receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29110", "l": "H(+) + NADH + ubiquinone-8 <=> NAD(+) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749098", "l": "ORC1 binds to DNA at origin of replication sites (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.535054500181104", "identifiers": [{"i": "GO:0015106", "l": "bicarbonate transmembrane transporter activity", "d": ["Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73636", "l": "CTP(out) + dGMP(in) => CTP(in) + dGMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.38", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016084", "l": "myostimulatory hormone activity", "d": ["The action characteristic of myostimulatory hormone, a peptide hormone that stimulates muscle contraction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69734", "l": "CoA + phenylacetyl-AMP <=> AMP + H(+) + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20932", "l": "L-erythrulose 1-phosphate = dihydroxyacetone phosphate + formaldehyde", "d": []}, {"i": "EC:4.1.2.2", "l": "\"ketotetrose-phosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25332", "l": "3-dehydrocarnitine + H(+) + NADH => (R)-carnitine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61544", "l": "ent-kaur-16-en-19-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74478", "l": "(Z)-4'-methoxydehydrocyclopeptine + 2-oxoglutarate + O2 <=> (-)-4'-methoxycyclopenine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45913", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75716", "l": "CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + pantetheine 4'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14136", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70745", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417927", "l": "P2Y2 receptor binds ATP and UTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937034", "l": "IRAK1 phosphorylates Pellino (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33790", "l": "3'-ketolactose + H2O <=> 3-keto-beta-D-galactose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.-", "l": "\"Acting on carbohydrates and derivatives\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749609", "l": "BCHE hydrolyzes ASA- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74707", "l": "Binding of IRS to insulin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38886", "l": "a fatty acid + ATP + CoA <=> a fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43295", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102777", "l": "caffeoyl-CoA:pelargonidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: anthocyanidin 3,5-di-O-beta-D-glucoside + caffeoyl-CoA <=> pelargonidin-3,5-diglucoside-5-O-caffeoylglucoside + coenzyme A(4-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69969", "l": "Ca(2+)(in) + K(+)(in) + 4 Na(+)(out) => Ca(2+)(out) + K(+)(out) + 4 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076371", "l": "GLCE epimerises more GlcA to IdoA as sulfate content rises (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700171", "l": "Active ALK phosphorylates PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36256", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0016303", "l": "1-phosphatidylinositol-3-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43144", "l": "adenosine(22) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.217", "l": "\"tRNA (adenine(22)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18481", "l": "cyclohexylsulfamate + H2O = cyclohexylamine + sulfate", "d": []}, {"i": "EC:3.10.1.2", "l": "\"cyclamate sulfohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052587", "l": "diacetyl reductase ((R)-acetoin forming) activity", "d": ["Catalysis of the reaction: (R)-acetoin + NAD+ = diacetyl + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196026", "l": "Dab2 is recruited to the junctional plaques (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0010853", "l": "cyclase activator activity", "d": ["Binds to and increases the activity of an enzyme that catalyzes a ring closure reaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28388", "l": "di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636247", "l": "PPE2:KPNA1:KPNB1 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45376", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.80", "l": "\"methylcytosine dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67583", "l": "3'-phosphoadenylyl sulfate + tauro-alpha-muricholate <=> adenosine 3',5'-bisphosphate + H(+) + tauro-alpha-muricholate 7-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27626", "l": "D-erythrose 4-phosphate + D-xylulose 5-phosphate = beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16412", "l": "1,2-dihydrovomilenine + NADP(+) <=> H(+) + NADPH + vomilenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783670", "l": "CRLF1 binds CLCF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804253", "l": "MDM2 ubiquitinates JMY (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53429", "l": "a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] => a thymidine in DNA + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9634850", "l": "NPAS4 binds ARNT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21428", "l": "(2R)-3-sulfolactate = H(+) + pyruvate + sulfite", "d": []}, {"i": "EC:4.4.1.24", "l": "\"(2R)-sulfolactate sulfo-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442345", "l": "hZIP10 mediates zinc influx into cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60771", "l": "3 2-oxoglutarate + gibberellin A12 + 3 O2 <=> 3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41452", "l": "5-methyl-1-naphthoate + H(+) + NADPH + O2 = 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.189", "l": "\"5-methyl-1-naphthoate 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5622129", "l": "FABP5 binds atRA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351207", "l": "Spermine  => N-acetylated spermine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692749", "l": "CDC14A,B bind MAPK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55115", "l": "4-methyl-3-oxopentanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13572", "l": "ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001859", "l": "complement component C3dg receptor activity", "d": ["Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654224", "l": "Activated FGFR3 binds PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16881", "l": "hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate", "d": []}, {"i": "EC:2.8.1.1", "l": "\"thiosulfate sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939335", "l": "RNF181 polyubiquinates BCL10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665761", "l": "FMNL3 binds RHOC:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67220", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA + NAD(+) = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212614", "l": "Glutamine transport from astrocytes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173626", "l": "Activation of C1r (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246693", "l": "APC is K63-polyubiquitinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0071814", "l": "protein-lipid complex binding", "d": ["Binding to a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73160", "l": "FMN(out) + NAD(+)(in) => FMN(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57118", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51177", "l": "cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72931", "l": "O2 + proatranorin IV + reduced [NADPH--hemoprotein reductase] = atranorin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18952", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.40", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53913", "l": "butanoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.297", "l": "\"limonene-1,2-diol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55446", "l": "cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolate + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140351", "l": "glycosylceramide flippase activity", "d": ["Catalysis of the movement of glycosylceramide from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Glycosylceramides are ceramides containing a functional group derived from a sugar."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709831", "l": "HSP90 binds TBK1 and IRF3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67341", "l": "malonyl-CoA + quercetin 3-O-beta-D-glucoside => CoA + quercetin 3-O-(6-O-malonyl-beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46674", "l": "5beta-dihydroaldosterone + NADP(+) => aldosterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28017", "l": "S-adenosyl-L-methionine + thiocyanate <=> methyl thiocyanate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39182", "l": "(2E)-eicosenoyl-CoA + H(+) + NADPH <=> eicosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047585", "l": "4-pyridoxolactonase activity", "d": ["Catalysis of the reaction: 4-pyridoxolactone + H2O = 4-pyridoxate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225894", "l": "Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42702", "l": "6-carboxyhexanoyl-[ACP] + H(+) + methanol => 6-carboxyhexanoyl-[ACP] methyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71889", "l": "H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide => GTP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31876", "l": "(S)-2,3-epoxysqualene => marneral", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53857", "l": "NADP(+) + ursocholate => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112395", "l": "Abortive termination of elongation after arrest (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004144", "l": "diacylglycerol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63909", "l": "ATP + H2O + pravastatin(in) => ADP + H(+) + phosphate + pravastatin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018450", "l": "myrtenol dehydrogenase activity", "d": ["Catalysis of the reaction: myrtenol + O2 + 2 H+ + 2 e- = 2 H2O + myrtenal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192315", "l": "Bile salts are translocated from the peroxisomal matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69064", "l": "N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + O2 = H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210300", "l": "Interaction of DAP12 and TREM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37316", "l": "glycyl-L-glutamine + H2O => glycine + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10273", "l": "a 1,2-diacyl-sn-glycerol + ATP => a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57007", "l": "acetyl-CoA + streptothricin D <=> CoA + H(+) + N(beta)-acetylstreptothricin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71662", "l": "a D-glucoside + 2 Fe(III)-[cytochrome c] <=> a 3-dehydro-D-glucoside + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008777", "l": "acetylornithine deacetylase activity", "d": ["Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74784", "l": "tyramine(in) => tyramine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986083", "l": "USP33 deubiquitinates ROBO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018542", "l": "NOTCH3 coactivator complex binds DLGAP5 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33800", "l": "L-histidinol + NAD(+) => H(+) + L-histidinal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47020", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O = [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30836", "l": "H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0097599", "l": "xylanase activity", "d": ["Catalysis of the hydrolysis of xylans, homopolysaccharides composed of xylose residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199404", "l": "CD40L binds CD40 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202709", "l": "JAM2 dimerises (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651828", "l": "PARG dePARylates PARP1,PARP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60847", "l": "a 5'-end diphospho-guanosine in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54194", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => L-lysyl-[protein] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11600", "l": "ATP + CMP = ADP + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58762", "l": "1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030350", "l": "iron-responsive element binding", "d": ["Binding to an iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61732", "l": "steviol + UDP-alpha-D-glucose = H(+) + steviolmonoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180004", "l": "RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-tyrosine (consensus YSPTSPS)(position 1) + H2O = RNA polymerase II large subunit + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211350", "l": "PDX1-dependent synthesis of NKX6-1 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19152", "l": "L-arginyl-[protein] + NAD(+) <=> H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70049", "l": "H2O + kynurenate + L-2-aminoadipate => 2-oxoadipate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62374", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71842", "l": "dehydroepiandrosterone 3-sulfate(out) <=> dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41155", "l": "1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-(8E)-octadecenoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11293", "l": "2 H(+) + O2 + rifamycin B => H2O2 + rifamycin O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055055", "l": "D-glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose + H+ = D-glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. D-glucose is the dextrorotatory D-enantiomer of glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33505", "l": "ADP + H(+) + itraconazole(out) + phosphate => ATP + H2O + itraconazole(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036348", "l": "hydantoin racemase activity", "d": ["Catalysis of the reaction: D-5-monosubstituted hydantoin = L-5-monosubstituted hydantoin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56954", "l": "CDP + H(+) + phosphoenolpyruvate => CTP + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18988", "l": "chorismate <=> isochorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666426", "l": "CRKII:DOCK180:ELMO binds FCGR3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20086", "l": "a flavonol 3-O-beta-D-glucoside + malonyl-CoA => a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64946", "l": "dCMP + 2 H(+) + 2 phosphate => dCTP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13400", "l": "6-oxohexanoate + H2O + NADP(+) <=> 2 H(+) + hexanedioate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30463", "l": "(2Z,6Z)-farnesyl diphosphate = (+)-alpha-santalene + diphosphate", "d": []}, {"i": "EC:4.2.3.50", "l": "\"(+)-alpha-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805792", "l": "p-S291-PHF20 translocates to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193669", "l": "TRAF6 binds to p75NTR:NRIF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008387", "l": "steroid 7-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52665", "l": "a short-chain (3S)-3-hydroxyacyl-CoA => a short-chain (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52145", "l": "3-phosphonopyruvate + acetyl-CoA + H2O => (R)-2-(phosphonomethyl)malate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50093", "l": "a fatty acyl-CoA + taurine => an N-fatty acyl-taurine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43892", "l": "[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine", "d": []}, {"i": "EC:2.8.1.7", "l": "\"cysteine desulfurase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53593", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + H2O => 1-tetradecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18706", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004447", "l": "iodide peroxidase activity", "d": ["Catalysis of the reaction: iodide + H2O2 = iodine + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428609", "l": "Type I Na+-coupled phosphate co-transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202731", "l": "JAM3 dimerises (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18721", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = diphosphate + ent-13-epi-manoyl oxide", "d": []}, {"i": "EC:4.2.3.186", "l": "\"ent-13-epi-manoyl oxide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250884", "l": "botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052796", "l": "exo-alpha-(2->8)-sialidase activity", "d": ["Catalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12004", "l": "indoxyl + UDP-alpha-D-glucose = H(+) + indican + UDP", "d": []}, {"i": "EC:2.4.1.220", "l": "\"indoxyl-UDPG glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32742", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12742", "l": "ADP + H(+) + H2O => IDP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19356", "l": "glycocholate + H2O <=> cholate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43316", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67123", "l": "N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11296", "l": "2,5-dioxopentanoate + H2O + NADP(+) = 2-oxoglutarate + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.26", "l": "\"2,5-dioxovalerate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0000099", "l": "sulfur amino acid transmembrane transporter activity", "d": ["Enables the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31040", "l": "dodecanoyl-CoA + FAD + H(+) => (2E)-dodecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161668", "l": "PGA2 is dehydrated to 15d-PGA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809680", "l": "MTMR12 binds MTM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55532", "l": "H(+) + H2O + L-phenylalanine + O2 = 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": []}, {"i": "EC:4.1.1.109", "l": "\"phenylacetaldehyde synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36043", "l": "all-trans-8'-apo-beta-carotenal + O2 = 13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial", "d": []}, {"i": "EC:1.13.11.82", "l": "\"8'-apo-carotenoid 13,14-cleaving dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110360", "l": "Recruitment of POLB to the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004794", "l": "L-threonine ammonia-lyase activity", "d": ["Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783530", "l": "gp130:JAKs bind CNTFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004963", "l": "follicle-stimulating hormone receptor activity", "d": ["Combining with follicle-stimulating hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41787", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)/18:0) <=> CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209118", "l": "Membrane localised SGG phosphorylates ARR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050045", "l": "laminaribiose phosphorylase activity", "d": ["Catalysis of the reaction: 3-beta-D-glucosyl-D-glucose + phosphate = D-glucose + alpha-D-glucose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60977", "l": "(E)-4-hydroxynon-2-en-1-ol + NAD(+) => (E)-4-hydroxynon-2-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0003810", "l": "protein-glutamine gamma-glutamyltransferase activity", "d": ["Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948180", "l": "Peroxynitrite oxidizes Cys residues (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51874", "l": "diphosphate + osthenol => dimethylallyl diphosphate + umbelliferone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58728", "l": "adenosine in rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.36", "l": "\"caspase-1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30034", "l": "(S)-muconolactone <=> cis,cis-muconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49970", "l": "17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57935", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799409", "l": "HIPK2 phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34365", "l": "diphosphate + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28960", "l": "D-xylose(in) + H(+)(in) => D-xylose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12054", "l": "diphosphate + trichodiene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24118", "l": "(S)-linalool + diphosphate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12686", "l": "2 mycothiol + NADP(+) => H(+) + mycothione + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33602", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72691", "l": "Formation of the 43S pre-initiation complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756150", "l": "PON1,3 hydrolyse 4-OH-ATVL to 4-OH-ATV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36829", "l": "D-glucose + diosgenin + 2 L-rhamnopyranose => dioscin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36248", "l": "(E)-anol + S-adenosyl-L-methionine => (E)-anethole + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32844", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol => a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.263", "l": "\"abscisate beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46374", "l": "a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24234", "l": "3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH => 2-dehydro-3-deoxy-D-gluconate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995388", "l": "PP2A dephosphorylates BANF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31574", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 <=> CO2 + H2O + NADP(+) + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627104", "l": "XIAP binds CASP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27881", "l": "2',3'-cyclophospho-UMP + H2O <=> 3'-UMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110240", "l": "MPG glycosylase mediated recognition and binding of hypoxanthine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16468", "l": "(R)-lactate + 2 Fe(III)-[cytochrome c553] <=> 2 Fe(II)-[cytochrome c553] + 2 H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983427", "l": "Expression of peptide bound class I MHC on cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74595", "l": "(2S,3R)-3-methyl-L-aspartate = mesaconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76009", "l": "(3R)-hydroxybutanoate tetramer + (R)-3-hydroxybutanoate + H(+) => (3R)-hydroxybutanoate pentamer + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48855", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 <=> 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50856", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68132", "l": "phytol + tetradecanoyl-CoA = CoA + tetradecanoate phytyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698758", "l": "FLT3 ITD- and NOX4-dependent H2O2 production (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25274", "l": "ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73955", "l": "3,4-dihydroxystyrene + H(+) + NADH = 4-ethylcatechol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451347", "l": "Activation of JNK by DSCAM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781001", "l": "EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001641", "l": "group II metabotropic glutamate receptor activity", "d": ["A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75552", "l": "2 a (3R)-3-isocyanyl-fatty acyl-[ACP] + ATP + L-lysine + 2 NADPH => AMP + an isonitrile lipopeptide + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42425", "l": "2-methylmaleate + H2O => (2R,3S)-3-methylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004635", "l": "phosphoribosyl-AMP cyclohydrolase activity", "d": ["Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H2O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987039", "l": "JAK1 binds IL20RA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66481", "l": "gypsogenin + UDP-alpha-D-glucose => gypsogenin 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211224", "l": "Association of DFF40 with DFF45 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23303", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate <=> (2Z,6E)-farnesyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645535", "l": "ALPK1 phosphorylates TIFA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44534", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047111", "l": "formate dehydrogenase (cytochrome-c-553) activity", "d": ["Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031994", "l": "insulin-like growth factor I binding", "d": ["Binding to insulin-like growth factor I."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15822", "l": "2 A + glycine => 2 AH2 + CO2 + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839080", "l": "Activated cytosolic FGFR1 fusions bind PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75081", "l": "32-hydroxy-24,25-dihydrolanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33123", "l": "all-trans-heptaprenyl diphosphate = (R)-tetraprenyl-beta-curcumene + diphosphate", "d": []}, {"i": "EC:4.2.3.130", "l": "\"tetraprenyl-beta-curcumene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15349", "l": "L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate", "d": []}, {"i": "EC:2.3.1.35", "l": "\"glutamate N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58259", "l": "H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] <=> ADP-D-ribose + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.4", "l": "\"minus-end-directed kinesin ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64355", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA <=> 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56487", "l": "3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] <=> gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672011", "l": "p-AMPK:AMP binds the ULK complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170978", "l": "p-FRS2:CRKL binds C3G (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199579", "l": "KIR2DL4 interacting with HLA-G (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38009", "l": "6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine => 6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57076", "l": "3-oxoisoapionate 4-phosphate + H2O = (2R)-3-phosphoglycerate + glycolate + H(+)", "d": []}, {"i": "EC:3.7.1.28", "l": "\"3-oxoisoapionate-4-phosphate transcarboxylase/hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757574", "l": "ALB binds PREDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209792", "l": "N-acetylation of serotonin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18638", "l": "H2 + NADP(+) => H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74381", "l": "2 (S)-lactate(out) + prostaglandin H2(in) => 2 (S)-lactate(in) + prostaglandin H2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55139", "l": "ATP + D-alanine + H(+) <=> D-alanyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008043", "l": "MAPK8 phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33639", "l": "ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18771", "l": "2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036209", "l": "9beta-pimara-7,15-diene oxidase activity", "d": ["Catalysis of the reaction: 9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211164", "l": "AKT phosphorylates FOXO1A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174967", "l": "NAT2 acetylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2214324", "l": "Collagen type VII dimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5246478", "l": "APOM binds retinoids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866851", "l": "CFTR transits to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111879", "l": "PIP2 hydrolysis (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24250", "l": "glycine + pyruvate => glyoxylate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18973", "l": "2-oxoglutarate + deacetoxyvindoline + O2 = 4-O-deacetylvindoline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20159", "l": "an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+) => a polyvinyl alcohol + 2n Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685604", "l": "SLAMF6 binds SLAMF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18405", "l": "H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate", "d": []}, {"i": "EC:1.4.1.1", "l": "\"alanine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41339", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64044", "l": "(13Z)-docosenoyl-CoA + sphing-4-enine = CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40391", "l": "1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA = 1-O-alkyl-2,3-diacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612277", "l": "SPARC gene transcription is stimulated by ERBB4s80 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61865", "l": "AH2 + dehydroprobetaenone I => A + probetaenone I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11855", "l": "phosphate + S-methyl-5'-thioadenosine <=> adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848774", "l": "PTK6 binds DOK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445084", "l": "Phosphorylation of L1 by SRC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59988", "l": "cyclohexane-1-carbonyl-CoA + NADP(+) = cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549060", "l": "NrCAM binds Neuropilin-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004326", "l": "tetrahydrofolylpolyglutamate synthase activity", "d": ["Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047432", "l": "2,2-dialkylglycine decarboxylase (pyruvate) activity", "d": ["Catalysis of the reaction: 2,2-dialkylglycine + H+ + pyruvate = L-alanine + CO2 + dialkyl ketone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63512", "l": "biphenyl-2,2'-diol + H(+) + NADH + O2 = biphenyl-2,2',3-triol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53980", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57855", "l": "a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O <=> 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141439", "l": "Release of activated MAD2 from kinetochores (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57288", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O = a guanosine in RNA + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73001", "l": "L-tryptophan + N-terminal L-alpha-aminoacyl-[peptide] => H2O + N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70562", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O <=> L-threonyl-[protein] + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60286", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61811", "l": "holo-[peptidyl-carrier protein] + L-alanyl-5'-AMP <=> AMP + H(+) + L-alanyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031713", "l": "B2 bradykinin receptor binding", "d": ["Binding to a B2 bradykinin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21373", "l": "H(+) + H2O + urethane => CO2 + ethanol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562604", "l": "BfrA stores iron (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25273", "l": "ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate", "d": []}, {"i": "EC:6.3.2.37", "l": "\"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49352", "l": "2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000327", "l": "PLK1 phosphorylates BORA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16879", "l": "CO2 + hypotaurine => 3-sulfino-L-alanine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354066", "l": "Translocation of PTK2 to Focal complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9677050", "l": "Formation of the GCN5-ATAC complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018808", "l": "RAC3 binds effectors at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28262", "l": "3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose = 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP", "d": []}, {"i": "EC:2.7.8.32", "l": "\"3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose xylosylphosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928619", "l": "PAK1 binds RAC1:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30238", "l": "H2O + L-glutamate 5-semialdehyde + NAD(+) <=> 2 H(+) + L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928597", "l": "EPH:EFN dimers tetramerise (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54621", "l": "2-oxoglutarate + eicosanoyl-CoA + O2 => 2-hydroxyeicosanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64514", "l": "6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine => (3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.105", "l": "\"monocyclic monoterpene ketone monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909718", "l": "Formation of p-STAT1 homodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43581", "l": "A + D-arginine => AH2 + iminoarginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57186", "l": "S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] => L-cysteinyl-[protein] + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47492", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH = isodeoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73396", "l": "L-aspartate(in) + sulfate(out) => L-aspartate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5159250", "l": "ATF7IP binds SETDB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-190141", "l": "ALAD binds to Pb2+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57251", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP <=> dGTP + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22494", "l": "formamide + L-glutamate => H2O + N-formimidoyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003979", "l": "UDP-glucose 6-dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + 2 NAD+ + UDP-alpha-D-glucose = 3 H+ + 2 NADH + UDP-alpha-D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202459", "l": "Phosphorylation of Bcl10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1467466", "l": "ABCA4 mediates atRAL transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49013", "l": "aurachin C + H(+) + NADH + O2 => aurachin C epoxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102941", "l": "3,5-dihydroxyanisole O-methyltransferase activity", "d": ["Catalysis of the reaction: 3,5-dihydroxyanisole + S-adenosyl-L-methionine = H+ + 3,5-dimethoxyphenol + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990763", "l": "arrestin family protein binding", "d": ["Binding to a member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637699", "l": "CpnT hydrolyses NAD+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42199", "l": "(9Z)-heptadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-heptadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47098", "l": "(2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate => (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451474", "l": "Bacterial Flagellin binds TLR5 homodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48938", "l": "CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein] => 2-oxoglutarate + L-prolyl-[Skp1 protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9690449", "l": "S1PR1 bind S1P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23612", "l": "1,2-dihydro-alpha-santonin + NAD(+) = alpha-santonin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32372", "l": "all-trans-violaxanthin + 2 L-ascorbate => all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362450", "l": "Hh processing variants bind lectins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611721", "l": "β1-agonists bind ADRB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0140767", "l": "enzyme-substrate adaptor activity", "d": ["An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019826", "l": "oxygen sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75385", "l": "bromide(out) => bromide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10115", "l": "L-homocysteine + L-serine <=> H2O + L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41193", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate => 1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47128", "l": "ATP + CoA + deoxycholate = AMP + deoxycholoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64261", "l": "(9Z,12Z)-octadecadienoyl-CoA + glycine => CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48558", "l": "4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate => 4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26195", "l": "(S)-malyl-CoA + ADP + phosphate => (S)-malate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043828", "l": "tRNA 2-selenouridine synthase activity", "d": ["Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33027", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene = 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17456", "l": "5-phospho-beta-D-ribosylamine + ATP + glycine <=> ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28409", "l": "H2O + XTP <=> H(+) + phosphate + XDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16574", "l": "2-oxoglutarate + 4-(phosphooxy)-L-threonine => (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35174", "l": "H(+)(out) + novobiocin(in) <=> H(+)(in) + novobiocin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373075", "l": "Metabotropic glutamate receptors bind glutamate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451377", "l": "Interaction of IQGAP1 with nephrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22630", "l": "(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52148", "l": "a (Z)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose = an aliphatic (Z)-desulfo-glucosinolate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37355", "l": "H2O + uridine 2'-phosphate = phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21670", "l": "ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in) => ATP + H2O + sn-glycerol 3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55360", "l": "11-cis-retinol = 9-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27750", "l": "2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10647", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H2O <=> (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24403", "l": "ATP + UMP <=> ADP + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71693", "l": "glycyl-L-glutamate(in) + 2 H(+)(in) => glycyl-L-glutamate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66362", "l": "(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+) => (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64524", "l": "(2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA = 2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43643", "l": "dodecanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxotetradecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10413", "l": "ADP-D-ribose + H2O => AMP + D-ribose 5-phosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48663", "l": "8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64155", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55597", "l": "globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine => globoside NORint + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37925", "l": "(8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46020", "l": "[pyruvate, water dikinase] + ADP = [pyruvate, water dikinase]-phosphate + AMP + H(+)", "d": []}, {"i": "EC:2.7.11.33", "l": "\"[pyruvate, water dikinase] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198669", "l": "p38MAPK phosphorylates MSK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877902", "l": "Activated AR binds RUNX2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18135", "l": "adenosine 5'-phosphosulfate + diphosphate => ATP + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49198", "l": "25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin] => 2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69211", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ATP + L-glutamate <=> (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5336443", "l": "LIN7, CASK and APBA1 bind (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43873", "l": "3-oxochol-4-en-22-oate + ATP + CoA => 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376122", "l": "DSCAM/DSCAML1 homodimerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19947", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004641", "l": "phosphoribosylformylglycinamidine cyclo-ligase activity", "d": ["Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873850", "l": "STARD5 binds DCA, LCA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202500", "l": "Activation of IKK complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45937", "l": "3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5631941", "l": "SESN1,2,3 bind AMPK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36892", "l": "(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 => (9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75723", "l": "(9Z,12Z)-octadecadienoate + H2O = (10S)-hydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48134", "l": "(2E,6E)-farnesol + phosphate => (2E,6E)-farnesyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928646", "l": "EPHAs bind EFNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102311", "l": "8-hydroxygeraniol dehydrogenase activity", "d": ["Catalysis of the reaction: (6E)-8-hydroxygeraniol + 2 NADP <=> (6E)-8-oxogeranial + 2 NADPH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30460", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol => (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10092", "l": "a 2'-deoxyribonucleoside 3'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate", "d": []}, {"i": "EC:3.1.3.34", "l": "\"deoxynucleotide 3'-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11072", "l": "anthranilate + 3 H(+) + NADPH + O2 = catechol + CO2 + NADP(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75355", "l": "H2O + L-mimosine = 3-hydroxy-4H-pyrid-4-one + NH4(+) + pyruvate", "d": []}, {"i": "EC:4.3.3.8", "l": "\"mimosinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351341", "l": "Exocytosis of Proactivator polypeptide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46295", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195275", "l": "Phosphorylation of APC component of the destruction complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047035", "l": "testosterone dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77081", "l": "Formation of the CE:GMP intermediate complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69564", "l": "12 ATP + L-asparagine + L-aspartate + L-cysteine + L-glutamate + L-histidine + 3 L-isoleucine + L-leucine + L-lysine + L-ornithine + L-phenylalanine = 12 AMP + bacitracin A + 12 diphosphate + 12 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050660", "l": "flavin adenine dinucleotide binding", "d": ["Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0034186", "l": "apolipoprotein A-I binding", "d": ["Binding to apolipoprotein A-I."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61122", "l": "2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase] => kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24829", "l": "ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": []}, {"i": "EC:6.3.1.21", "l": "\"phosphoribosylglycinamide formyltransferase 2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944227", "l": "Association of procollagen type XXII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33579", "l": "NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate = H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate", "d": []}, {"i": "EC:1.1.1.335", "l": "\"UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357432", "l": "AXL binds SRC-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004726", "l": "non-membrane spanning protein tyrosine phosphatase activity", "d": ["Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37727", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19611", "l": "4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.201", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004371", "l": "glycerone kinase activity", "d": ["Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50146", "l": "(9Z)-hexadecenoate + ethanol + H(+) => ethyl (9Z)-hexadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032770", "l": "Translocation of YAP1 to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73197", "l": "malonate(out) + sulfate(in) => malonate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5333671", "l": "CLCAs self cleave (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655193", "l": "KIAA0101 double monoubiquitination (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56178", "l": "8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+) => 8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38358", "l": "(R)-3-phenyllactoyl-CoA <=> (E)-cinnamoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60664", "l": "H2O + NADPH = NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170149", "l": "Translocation of active Cdc25C to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71096", "l": "2 Na(+)(out) + pregnenolone sulfate(out) => 2 Na(+)(in) + pregnenolone sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20668", "l": "1,5-anhydro-D-glucitol + NADP(+) <=> 1,5-anhydro-D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938382", "l": "LGALS3 gene expression is stimulated by RUNX1 and RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2317332", "l": "PIP3 recruits AKT to the membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60753", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone => CoA + jasmolin I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50518", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein] => acetyl-CoA + N-terminal L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564169", "l": "Collagen type VIII degradation by MMP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30434", "l": "(S)-2,3-epoxysqualene <=> taraxerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004781", "l": "sulfate adenylyltransferase (ATP) activity", "d": ["Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72206", "l": "2 chloride(out) + hydrogencarbonate(in) <=> 2 chloride(in) + hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111956", "l": "Calmodulin activates Cam-PDE 1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39581", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56936", "l": "17beta-hydroxy-androst-5-en-3-one = testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32761", "l": "(3R)-3-methyl-D-ornithine => L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52091", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA <=> 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11037", "l": "a quaternary ammonium(out) + ATP + H2O => a quaternary ammonium(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724099", "l": "ALK mutants:p-3Y SHC binds GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21621", "l": "FMNH2 + NAD(+) => FMN + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69758", "l": "(2-aminobenzyl)malonyl-CoA + H(+) + O2 <=> (E)-2-aminocinnamoyl-CoA + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22744", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.62", "l": "\"mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432164", "l": "Ca2+ influx into the post-synaptic cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592362", "l": "Activation of proMMP7 by MMP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694625", "l": "nsp3 cleaves nsp1-4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73934", "l": "chloride + FADH2 + griseophenone C + O2 <=> FAD + griseophenone B + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451347", "l": "Activation of JNK by DSCAM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18764", "l": "a 1,2-diacyl-sn-glycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70261", "l": "AMP(in) + phosphate(out) => AMP(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74283", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IIA = a 2-acyl-sn-glycero-3-phosphocholine + a lipid IIB", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140786", "l": "glutamine sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of glutamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196753", "l": "2xPPCS ligates PPanK with Cys (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497863", "l": "The BH3 radical can decay to dihydrobiopterin (BH2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74535", "l": "2 AH2 + 2 archaetidylglycerol + 4 S-adenosyl-L-methionine = 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether glycerophospholipid + 4 H(+) + 4 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56944", "l": "AH2 + D-ribulose 5-phosphate = 1-deoxy-D-xylulose 5-phosphate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "53.271590794397191", "identifiers": [{"i": "GO:0015276", "l": "ligand-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25239", "l": "ADP + CTP => ATP + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36938", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.44", "l": "\"lipopolysaccharide 3-alpha-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29323", "l": "fumarate(in) + succinate(out) = fumarate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11918", "l": "15-oxoprostaglandin E2 + H(+) + NADH => 13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168376", "l": "STIM1 oligomerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35681", "l": "3-oxotetradecasphinganine + CO2 + CoA => dodecanoyl-CoA + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22956", "l": "1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.77", "l": "\"plasmanylethanolamine desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31816", "l": "(2E,6E)-farnesyl diphosphate => (+)-(E)-beta-caryophyllene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20885", "l": "H2O + L-serine + NAD(+) => 3-hydroxypyruvate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37976", "l": "H(+) + homogentisate + phytyl diphosphate => 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69343", "l": "(E)-prop-1-en-1-SO-peroxol <=> (Z)-propanethial S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199935", "l": "MSK1 activates CREB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212432", "l": "Formation of DRIP coactivator complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10325", "l": "an L-glycol + NADP(+) => a 2-hydroxycarbonyl + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507870", "l": "Aquaporins passively transport water out of cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62086", "l": "AMP + D-glucosamine 6-phosphate + H(+) => ADP + D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004068", "l": "aspartate 1-decarboxylase activity", "d": ["Catalysis of the reaction: L-aspartate = beta-alanine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20144", "l": "an S-alkyl-L-cysteine S-oxide <=> 2-aminoprop-2-enoate + an S-alkyl sulfenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25723", "l": "L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21696", "l": "N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53673", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 => 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389083", "l": "Autophosphorylation of PDGF alpha receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694522", "l": "Inner coat assembly and cargo binding (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32532", "l": "4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate => alpha-D-mannose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448958", "l": "Nuclear translocation of p38 MAPK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38291", "l": "(S)-malyl-CoA + H2O = (S)-malate + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.30", "l": "\"(3S)-malyl-CoA thioesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17297", "l": "2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA", "d": []}, {"i": "EC:1.2.7.3", "l": "\"2-oxoglutarate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75563", "l": "cyathadiol + O2 + reduced [NADPH--hemoprotein reductase] = cyathatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40029", "l": "(13S)-vitexifolin A + diphosphate => 9alpha-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570528", "l": "SUMOylation of XPC with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26276", "l": "Co-precorrin-3 + S-adenosyl-L-methionine <=> Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0043425", "l": "bHLH transcription factor binding", "d": ["Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59018", "l": "CO2 + cycloeucalenone + NADH => 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27872", "l": "(2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+) => (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2219524", "l": "PDPK1 binds PIP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51057", "l": "A + androst-4-ene-3,17-dione => AH2 + androsta-1,4-diene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39746", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18199", "l": "cyclohexyl isocyanide + H2O => N-cyclohexylformamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75581", "l": "AH2 + cyathin A3 => A + cyathatriol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26005", "l": "D-arabinitol 1-phosphate + NAD(+) <=> D-xylulose 5-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635915", "l": "ATF4 and CEBPB,CEBPG bind the ASNS gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50329", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371353", "l": "Soluble TNF-α binds TNFR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26285", "l": "Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.195", "l": "\"cobalt-precorrin-5B (C(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22672", "l": "2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphate", "d": []}, {"i": "EC:2.5.1.103", "l": "\"presqualene diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193668", "l": "p75NTR and RHOA-GDI interact (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16235", "l": "2-dehydropantoate + H(+) + NADPH => (R)-pantoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211983", "l": "CYP2J2 oxidises ARA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10065", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O => (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050104", "l": "L-gulonate 3-dehydrogenase activity", "d": ["Catalysis of the reaction: L-gulonate + NAD+ = 3-dehydro-L-gulonate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34190", "l": "(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1028820", "l": "Formation of VAF (virus-activated factor) complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42717", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate => (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046537", "l": "2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity", "d": ["Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D glycerate; this reaction does not require the cofactor 2,3-bisphosphoglycerate."]}, {"i": "EC:5.4.2.12", "l": "\"phosphoglycerate mutase (2,3-diphosphoglycerate-independent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199839", "l": "AKT can phosphorylate RSK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51790", "l": "2-hydroxybenzoyl-CoA + AMP + H(+) => 2-hydroxybenzoyl-5'-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029468", "l": "Conversion of PA into DAG by PAP-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67033", "l": "4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] => 4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58072", "l": "a 4,5-didehydrojasmonate + H(+) + NADPH = a jasmonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27723", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose => 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12214", "l": "9H-fluoren-9-one + H(+) + NADPH => 9H-fluoren-9-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17781", "l": "H2O + N-formyl-L-methionine = formate + L-methionine", "d": []}, {"i": "EC:3.5.1.31", "l": "\"formylmethionine deformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61331", "l": "O2 + parthenolide + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399999", "l": "AKT1 E17K mutant phosphorylates RSK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1972385", "l": "ADP-Ribosylation of HNP-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20768", "l": "3-phosphonopyruvate + H(+) = CO2 + phosphonoacetaldehyde", "d": []}, {"i": "EC:4.1.1.82", "l": "\"phosphonopyruvate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21559", "l": "[calmodulin]-L-lysine + S-adenosyl-L-methionine <=> [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48364", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69795", "l": "D-aspartyl-tRNA(Asp) + H2O = D-aspartate + H(+) + tRNA(Asp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74885", "l": "GUCYs converts GTP to cGMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14488", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-juneol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047400", "l": "phosphonoacetate hydrolase activity", "d": ["Catalysis of the reaction: H2O + phosphonoacetate = acetate + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24292", "l": "acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate", "d": []}, {"i": "EC:2.3.1.1", "l": "\"amino-acid N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71700", "l": "H(+)(out) + L-phenylalanyl-L-leucine(out) => H(+)(in) + L-phenylalanyl-L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62312", "l": "salicylate + UDP-alpha-D-glucose = H(+) + salicylate 2-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28690", "l": "(S)-dihydroorotate + ubiquinone-8 <=> orotate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015272", "l": "ATP-activated inward rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force."]}, {"i": "REACT:R-HSA-5683209", "l": "Activating ABCC8 mutants cause hyperglycemia in permanent neonatal diabetes mellitus (PNDM) and transient neonatal DM (TNDM). (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.117", "l": "\"stratum corneum chymotryptic enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944230", "l": "Association of procollagen type XVIII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592362", "l": "Activation of proMMP7 by MMP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73873", "l": "(R)-noradrenaline(in) => (R)-noradrenaline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70243", "l": "an N-acylsphing-4-enine + UDP-alpha-D-xylose = a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23029", "l": "malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein] => acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939938", "l": "ESRRA:PPARG1CB binds the RUNX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63235", "l": "(2E)-octenoyl-CoA + H(+) + NADH <=> NAD(+) + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65145", "l": "2-oxoglutarate + berkeleyone A + O2 => CO2 + H2O + preaustinoid A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.28", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63262", "l": "4-pyridoxate + NAD(+) => 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65604", "l": "(4R)-hydroxysphinganine + eicosanoyl-CoA = CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604712", "l": "Initial activation of proMMP7 by trypsin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50309", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48806", "l": "(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49785", "l": "chenodeoxycholoyl-CoA + taurine => CoA + H(+) + taurochenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17918", "l": "[Glu(-Cys)](n)-Gly + glutathione + H(+) => [Glu(-Cys)](n+1)-Gly + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.147", "l": "\"22alpha-hydroxysteroid 23-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937844", "l": "SRC,YES1 phosphorylate YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37743", "l": "dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2", "d": []}, {"i": "EC:2.5.1.129", "l": "\"flavin prenyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57345", "l": "3-hydroxy-D-kynurenine + S-adenosyl-L-methionine => 3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140806", "l": "SERPINC1 binds SERPINC1 activators (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008577", "l": "IL37:IL18R1 binds SIGIRR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16658", "l": "H2O + inosine => D-ribose + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187506", "l": "Translocation of p27 to the nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388596", "l": "Melanocortin receptors bind melanocortins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37777", "l": "1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140867", "l": "NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of ADP-ribose groups to the glutamate-18 residue of histone H2B (or an equivalent residue)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34489", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+) => dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.-.-.-", "l": "\"Transferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031218", "l": "arabinogalactan endo-1,4-beta-galactosidase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34607", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine = a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871506", "l": "SORL1 transports APP(18-770) from endosome lumen to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.32", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45370", "l": "(4R)-hydroxysphinganine + (9Z)-octadecenoate => H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050465", "l": "nitroquinoline-N-oxide reductase activity", "d": ["Catalysis of the reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033945", "l": "oligoxyloglucan reducing-end-specific cellobiohydrolase activity", "d": ["Catalysis of the hydrolysis of cellobiose from the reducing end of xyloglucans consisting of a beta-(1->4) linked glucan carrying alpha-D-xylosyl groups on O-6 of the glucose residues. To be a substrate, the first residue must be unsubstituted, the second residue may bear a xylosyl group, whether further glycosylated or not, and the third residue, which becomes the new terminus by the action of the enzyme, is preferably xylosylated, but this xylose residue must not be further substituted."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56893", "l": "H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose => NADP(+) + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48159", "l": "ganglioside GQ1b (d18:1(4E)) + H2O <=> ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2484822", "l": "Kinetochore assembly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71303", "l": "RPE dimers isomerise RU5P to XY5P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676268", "l": "Formation of the MLL4 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.264511229695032", "identifiers": [{"i": "GO:0008236", "l": "serine-type peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12552", "l": "(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA = (E)-pinosylvin + 4 CO2 + 4 CoA", "d": []}, {"i": "EC:2.3.1.146", "l": "\"pinosylvin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30323", "l": "all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38346", "l": "(20S)-ginsenoside Rd + H2O <=> (20S)-ginsenoside Rg3 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61748", "l": "rubusoside + UDP-alpha-D-glucose = H(+) + stevioside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39893", "l": "dTDP + H(+) + vancomycin => devancoaminyl-vancomycin + dTDP-beta-L-vancosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31131", "l": "5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5333678", "l": "CPNEs bind PL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13702", "l": "acetyl-CoA + L-homoserine => CoA + O-acetyl-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29243", "l": "H(+) + menaquinone-8 + NADH = menaquinol-8 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.7.3", "l": "\"N,N-dimethylglycine/sarcosine dehydrogenase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58608", "l": "2 L-ascorbate + N-decanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0031806", "l": "G protein-coupled histamine receptor binding", "d": ["Binding to a G protein-coupled (metabotropic) histamine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618093", "l": "ATP hydrolysis by HSP90 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62258", "l": "Cd(2+)(in) + 2 hydrogencarbonate(in) => Cd(2+)(out) + 2 hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2586559", "l": "Leptin Binds Leptin Receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814094", "l": "ARL1:GTP binds ARFIP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35302", "l": "3-hydroxyoctadecanoyl-CoA + NADP(+) <=> 3-oxooctadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928576", "l": "RHOA:GTP binds ROCK, activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68014", "l": "H2O2 + xanthine => H2O + hypoxanthine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.7", "l": "\"inulinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71029", "l": "L-glutamine(out) + L-phenylalanine(in) => L-glutamine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20607", "l": "NH4(+) + uracil => cytosine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68292", "l": "L-seryl-[protein] + nonanoyl-CoA = CoA + O-nonanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25278", "l": "3',5'-cyclic AMP + H2O => AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.6", "l": "\"carboxypeptidase D\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201603", "l": "Caspase-mediated cleavage of PKC theta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68879", "l": "ATP + H(+) + NADPH + piperonylate <=> AMP + diphosphate + NADP(+) + piperonal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46937", "l": "(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) => ATP + H(+) + L-2-aminoadipate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791108", "l": "Expression of SULT1A3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63914", "l": "6-azauridine 5'-phosphate + ADP + H(+) => 6-azauridine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36097", "l": "methyl salicylate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25618", "l": "terpentedienyl diphosphate => diphosphate + terpentetriene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018710", "l": "acetone carboxylase activity", "d": ["Catalysis of the reaction: acetone + ATP + CO2 + 2 H2O = acetoacetate + AMP + 4 H+ + 2 phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23009", "l": "alpha,alpha-trehalose 6-phosphate + H2O => D-glucose + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684273", "l": "3CLp cleaves pp1a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004777", "l": "succinate-semialdehyde dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865605", "l": "BRWD1 binds SMARCA4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16651", "l": "(S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38061", "l": "1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55060", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] = a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25588", "l": "D-threo-isocitrate + NADP(+) = (S)-oxalosuccinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46072", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADH = hexadecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050695", "l": "benzoylformate decarboxylase activity", "d": ["Catalysis of the reaction: benzoylformate = benzaldehyde + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55304", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30085", "l": "4 Cu(2+) + 2 H2O => 4 Cu(+) + 4 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53334", "l": "2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25729", "l": "H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17395", "l": "3-fumarylpyruvate => 3-maleylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72217", "l": "2 hydrogencarbonate(in) + Na(+)(in) => 2 hydrogencarbonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52480", "l": "16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28307", "l": "beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose => beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74177", "l": "a ketone + H(+) + NADH + NH4(+) => a secondary alkyl amine + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11801", "l": "H2O + NAD(+) => AMP + beta-nicotinamide D-ribonucleotide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74961", "l": "(3R)-3-isocyanylbutanoyl-[ACP] + AMP + diphosphate => (3R)-3-isocyanylbutanoate + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66622", "l": "(25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0015459", "l": "potassium channel regulator activity", "d": ["Binds to and modulates the activity of a potassium channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54639", "l": "(13E)-labda-7,13-dien-15-yl diphosphate <=> diphosphate + labda-7,13(16),14-triene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70551", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-galactose = 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54503", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> beta-geranylfarnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10368", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": []}, {"i": "EC:2.6.1.59", "l": "\"dTDP-4-amino-4,6-dideoxygalactose transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72463", "l": "L-threonyl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56661", "l": "7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74258", "l": "XDH oxidizes xanthine to form urate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004397", "l": "histidine ammonia-lyase activity", "d": ["Catalysis of the reaction: L-histidine = urocanate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72580", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O => (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60272", "l": "N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34192", "l": "(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O => (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10907", "l": "[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A <=> AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47806", "l": "epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670888", "l": "F9 variant is not secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390276", "l": "4,8,12-trimethyltridecanoyl-CoA + 2 O2 + 2 H2O + 2 NAD+ + 2 CoASH => 4,8-dimethylnonanoyl-CoA + 2 H2O2 + 2 NADH + 2 H+ + acetyl-CoA + propionyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53421", "l": "8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine => H(+) + roseoflavin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008035", "l": "high-density lipoprotein particle binding", "d": ["Binding to high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75080", "l": "24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 32-hydroxy-24,25-dihydrolanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50065", "l": "ATP + H2O + taurochenodeoxycholate(in) => ADP + H(+) + phosphate + taurochenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38455", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189488", "l": "UROS transforms HMB to URO3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65009", "l": "ATP + decanoate + H(+) => decanoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69173", "l": "Joining of adjacent Okazaki fragments (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71723", "l": "H(+)(out) + L-alanyl-L-leucyl-L-alanine(out) = H(+)(in) + L-alanyl-L-leucyl-L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25940", "l": "8-chloroquinoline + A + H2O = 8-chloroquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35703", "l": "1'-hydroxyversicolorone + H(+) + NADPH + O2 = (2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62563", "l": "(4R)-limonene + A + H2O <=> (4R)-perillyl alcohol + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38745", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75079", "l": "Formation of AT-AC C complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43267", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA <=> 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-517674", "l": "p-S158,221-HuR binds mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.481603666032214", "identifiers": [{"i": "GO:0016837", "l": "carbon-oxygen lyase activity, acting on polysaccharides", "d": ["Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide."]}, {"i": "EC:4.2.2.-", "l": "\"Acting on polysaccharides\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72200", "l": "Ca(2+)(in) + 2 H(+)(out) => Ca(2+)(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41863", "l": "(3R)-hydroxydecanoyl-[ACP] <=> (2E)-decenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17962", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => H2O + leukotriene A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0016744", "l": "transketolase or transaldolase activity", "d": ["Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.2.1.-", "l": "\"Transketolases and transaldolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8960973", "l": "RLBP1:11cRAL dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43704", "l": "ATP + H(+) + tetradecanoate = diphosphate + tetradecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57809", "l": "1-chloro-3-nitrobenzene + NADH + O2 => 3-chlorocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43918", "l": "(25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862184", "l": "USP48 cleaves polyubiquitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052750", "l": "reactive-black-5:hydrogen-peroxide oxidoreductase activity", "d": ["Catalysis of the reaction: reactive black 5 + hydrogen peroxide = oxidized reactive black 5 + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71897", "l": "H(+) + N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide => dGTP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57627", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618093", "l": "ATP hydrolysis by HSP90 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381644", "l": "ER calcium channels open in response to activated PKA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70676", "l": "H2O + Met-enkephalin-Arg-Phe => L-arginyl-L-phenylalanine + Met-enkephalin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174058", "l": "Degradation of multiubiquitinated Cdh1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354124", "l": "Phosphorylation of pPTK2 by SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13458", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H(+) => (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15893", "l": "Co-sirohydrochlorin + 2 H(+) = Co(2+) + sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0030580", "l": "quinone cofactor methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51460", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamate = (9Z)-octadecenoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39538", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA <=> (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024723", "l": "EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357479", "l": "p-AXL binds PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66015", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen] <=> [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25272", "l": "(R)-noradrenaline + S-adenosyl-L-methionine <=> (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009817", "l": "Acitretin binds to RAR:RXR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50995", "l": "thromboxane B2(out) <=> thromboxane B2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47345", "l": "7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37556", "l": "D-kanosamine 6-phosphate + H2O => kanosamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68129", "l": "a fatty acyl-CoA + phytol => a fatty acid phytyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947531", "l": "Molybdenum ion transfer onto molybdopterin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32302", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADH <=> 2 diphosphate + NAD(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21864", "l": "an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75365", "l": "thymidine(out) => thymidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74723", "l": "Endosome acidification (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36072", "l": "6-tuliposide A => D-glucose + tulipalin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24874", "l": "H2O + O-phospho-D-serine => D-serine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76052", "l": "Binding of TFIIIA To type 1 Promoter (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51547", "l": "D-ribulose <=> D-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75067", "l": "chloride(out) + 2 hydrogencarbonate(in) + Rb(+)(in) = chloride(in) + 2 hydrogencarbonate(out) + Rb(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62466", "l": "2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76006", "l": "glutarate(in) + xanthurenate(out) <=> glutarate(out) + xanthurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74705", "l": "5-dehydro-6-demethoxyfumagillol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21461", "l": "benzoin => 2 benzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051498", "l": "syn-copalyl diphosphate synthase activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate = 9alpha-copalyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48270", "l": "canthaxanthin + H2O => 4',4'-dihydroxyechinenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64372", "l": "beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O = alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33084", "l": "dehypoxanthine futalosine + S-adenosyl-L-methionine => 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63828", "l": "L-alanine + vanillin = pyruvate + vanillylamine", "d": []}, {"i": "EC:2.6.1.119", "l": "\"vanillin aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62551", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52432", "l": "(R)-2,3-diaminopropanoate + H(+) + H2O = 2 NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25998", "l": "H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine => H2O + N(1)-acetylspermine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46621", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol => (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61469", "l": "a cytidine in tRNA + S-adenosyl-L-methionine => a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851979", "l": "BTNL9 binds immune cell surfaces (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38917", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70469", "l": "a 2'-deoxycytidine in double-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in double-stranded DNA + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47140", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43271", "l": "ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GM2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57164", "l": "2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 = (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16471", "l": "(R)-2-benzylsuccinyl-CoA + succinate => (R)-2-benzylsuccinate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976716", "l": "NOTCH2 coactivator complex binds HES1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110360", "l": "Recruitment of POLB to the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35291", "l": "11-methyldodecanoyl-CoA + H(+) + malonyl-CoA = 3-oxoisopentadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43347", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) <=> [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.274502573267668", "identifiers": [{"i": "GO:0004407", "l": "histone deacetylase activity", "d": ["Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451377", "l": "Interaction of IQGAP1 with nephrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27760", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+) => (6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169895", "l": "Crk's SH3 domain engages C3G (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38676", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24020", "l": "2-(N(omega)-L-arginino)succinate = fumarate + L-arginine", "d": []}, {"i": "EC:4.3.2.1", "l": "\"argininosuccinate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1454916", "l": "The ABCC family mediates organic anion transport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416358", "l": "G alpha (q) inhibits PI3K alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13046", "l": "ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50506", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein] => acetyl-CoA + N-terminal L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60782", "l": "CO2 + gibberellin A24 + H2O + succinate => 2-oxoglutarate + gibberellin A15 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162657", "l": "Inactivation of Myt1 kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27812", "l": "(2Z,6Z)-farnesyl diphosphate + 2 diphosphate => dimethylallyl diphosphate + 2 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419389", "l": "LPA-binding receptors bind LPA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74063", "l": "2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45678", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928641", "l": "PAK binds RAC and bPIX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21431", "l": "(2R)-3-sulfolactate <=> H(+) + pyruvate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70488", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O + O2 => a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68823", "l": "(2Z,6E)-farnesyl diphosphate + H2O <=> (6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606839", "l": "Steryl sulfatase hydrolyses sulfate from steroid sulfates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46559", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + lathosterol + O2 <=> 7-dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47017", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O => [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19224", "l": "2 formaldehyde + H2O <=> formate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1982066", "l": "Ligand-independent phosphorylation of overexpressed FGFR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39859", "l": "1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol = a triacyl-sn-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5618331", "l": "HDAC6 deacetylates microtubules (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56659", "l": "12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34390", "l": "beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose <=> beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655244", "l": "Activated FGFR3 point and translocation mutants bind PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34953", "l": "3-hydroxypropanoate(in) => 3-hydroxypropanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74202", "l": "aspulvinone E + O2 <=> (2Z)-2-[(3,4-dioxocyclohexa-1,5-dien-1-yl)methylidene]-4-(4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-olate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354173", "l": "Activation of Rap1 by cytosolic GEFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24792", "l": "(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O <=> (2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668714", "l": "RAC1:GTP binds NOX1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944254", "l": "Association of procollagen type XXVI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42161", "l": "(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 => (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39097", "l": "3-oxodecanedioyl-CoA + H(+) + NADH => (3S)-hydroxydecanedioyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52323", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryptamine <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102620", "l": "3-geranylgeranylindole NADPH:oxygen oxidoreductase (10,11-epoxidizing) activity", "d": ["Catalysis of the reaction: 3-geranylgeranylindole + O2 + NADPH + H+ = 10,11-epoxy-3-geranylgeranylindole + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106145", "l": "scopoletin 8-hydroxylase activity", "d": ["Catalyzes of the reaction: scopoletin + 2-oxoglutarate+O2=fraxetin +succinate+ CO2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15055", "l": "(6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide => (6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5252133", "l": "ATP6AP1 binds V-ATPase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33457", "l": "CO2 + NADPH + zymosterone => 4alpha-carboxyzymosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043892", "l": "methylglyoxal reductase (NADPH-dependent) activity", "d": ["Catalysis of the reaction: lactaldehyde + NADP+ = methylglyoxal + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47178", "l": "(2E)-butenoyl-CoA + H2O => (2R)-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852552", "l": "MST1R autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58385", "l": "NADP(+) + octan-1-ol => H(+) + NADPH + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27370", "l": "acetoin + CoA + NAD(+) => acetaldehyde + acetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182988", "l": "Sprouty lures CBL away from EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13736", "l": "an n-alkanal + NAD(+) <=> an alk-2-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211716", "l": "Rho GTPase-activating protein 10 (RHG10) interacts with caspase-activated PAK-2p34 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3858475", "l": "ppDVL recruits RAC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340214", "l": "CYGB binds O2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52984", "l": "7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] = 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11252", "l": "H(+) + hydroxylamine + L-asparagine = beta-L-aspartylhydroxamate + NH4(+)", "d": []}, {"i": "EC:2.3.2.7", "l": "\"aspartyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11110", "l": "n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+) => n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58456", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O = (R)-glycerate + D-mannose", "d": []}, {"i": "EC:3.2.1.170", "l": "\"mannosylglycerate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47613", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26364", "l": "L-tyrosine + NADPH + S-adenosyl-L-methionine <=> 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168934", "l": "MAVS interacts with RIPK1 and FADD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42607", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26349", "l": "beta-L-galactose 1-phosphate + H2O = L-galactose + phosphate", "d": []}, {"i": "EC:3.1.3.93", "l": "\"L-galactose 1-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19539", "l": "D-mannitol + phosphate => D-mannitol 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381109", "l": "IRE1 binds IRE1 forming dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684140", "l": "ATM phosphorylates RBBP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53577", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13486", "l": "2-oxoglutarate + S-(4-bromophenyl)-L-cysteine => 3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34296", "l": "2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose => 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036307", "l": "23S rRNA (adenine(2030)-N(6))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + adenine(2030) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(2030) in 23S rRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38933", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16267", "l": "5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20753", "l": "A + 2 cob(II)alamin + 2 H(+) + 2 H2O => AH2 + 2 aquacob(III)alamin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53046", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0033892", "l": "deoxyribonuclease (pyrimidine dimer) activity", "d": ["Catalysis of the endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68462", "l": "a phenolic steroid 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a phenolic steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042085", "l": "5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43048", "l": "keto-D-tagatose = keto-D-sorbose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690152", "l": "USP5 cleaves polyubiquitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44362", "l": "3-hydroxy-2,4-dioxopentyl phosphate => (2S)-2-hydroxy-3,4-dioxopentyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299359", "l": "Activation of TALK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62299", "l": "(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) <=> (+)-malbrancheamide + 2 FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28376", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine => ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624272", "l": "MMPs cleave HB-EGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218824", "l": "p-6Y-VEGFR2 binds FYN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63465", "l": "(2E,6E,10E)-geranylgeraniol + UTP => (2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36443", "l": "dihydrochanoclavine-I aldehyde = 6,8-dimethyl-6,7-didehydroergoline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13627", "l": "3-methyl-2-butenal + adenine + AH2 => A + H2O + N(6)-dimethylallyladenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50640", "l": "2-(2-methylsulfanyl)ethylmalate = 3-(2-methylsulfanyl)ethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781953", "l": "YOD1 binds VCP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216043", "l": "Collagen type II binds integrin alpha10beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35233", "l": "rifampicin(out) => rifampicin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60464", "l": "2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50307", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675656", "l": "EDA:EDAR binds EDARADD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11173", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine => (6S)-5,6,7,8-tetrahydrofolate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14892", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate <=> (5Z,7E,9E,14Z,17Z)-icosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.45", "l": "\"E1 ubiquitin-activating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39399", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA = (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264458", "l": "Proteasome mediated degradation of COP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035279", "l": "Expression of APOC4 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158849", "l": "Phenol can form a sulfate conjugate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38838", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9698844", "l": "MLKL binds HSP90:CDC37 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102141", "l": "[chondroitin sulfate]-D-glucuronyl 2-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [chondroitin-sulfate]-beta-D-glucuronate = adenosine 3',5'-bismonophosphate + [chondroitin-sulfate]-2-O-sulfo-beta-D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34276", "l": "2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine => 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607722", "l": "Active NIK phosphorylates IKKA dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204850", "l": "Interaction of Tie2 and Dok-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.7", "l": "\"deoxyribonuclease V\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54174", "l": "2''-O-acyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40516", "l": "6-deoxy-6-sulfo-D-fructose 1-phosphate => (2S)-3-sulfolactaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31507", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate", "d": []}, {"i": "EC:4.3.3.6", "l": "\"pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016159", "l": "muconolactone delta-isomerase activity", "d": ["Catalysis of the reaction: (S)-muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202168", "l": "Phosphorylation of ZAP-70 by Lck (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72956", "l": "2 Na(+)(out) + nicotinate(out) => 2 Na(+)(in) + nicotinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186765", "l": "PLC-gamma binds to the active receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58504", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate = (3Z)-2-oxo-4-carboxy-3-hexenedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0016997", "l": "alpha-sialidase activity", "d": ["Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194678", "l": "CYP51A1 demethylates LNSOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.4", "l": "\"Xaa-Arg dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163213", "l": "Transfer of electrons through the succinate dehydrogenase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65892", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate = H2O + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19659", "l": "CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70958", "l": "H(+)(in) + L-glutamate(in) <=> H(+)(out) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417890", "l": "P2Y5 receptor can bind to LPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647746", "l": "EML4 trimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-481007", "l": "Exocytosis of platelet alpha granule contents (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43710", "l": "diphosphate + hexadecanoyl-AMP => ATP + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32990", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> a fatty acid + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29104", "l": "5 H(+)(in) + menaquinone-8 + NADH => 4 H(+)(out) + menaquinol-8 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32269", "l": "glycine + succinate semialdehyde => 4-aminobutanoate + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33910", "l": "4-(methylamino)butanoate + H2O + O2 <=> 4-aminobutanoate + formaldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30878", "l": "2-oxoglutarate + D-lysine <=> 6-amino-2-oxohexanoate + D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6813626", "l": "LEAP2 binds bacteria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23644", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2691219", "l": "NOTCH1 HD domain mutants bind DLL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674430", "l": "PDGFR mutants bind type II TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45245", "l": "(3E,5Z)-octadienoyl-CoA => (2E,4E)-octadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45191", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018789", "l": "cyclamate sulfohydrolase activity", "d": ["Catalysis of the reaction: cyclohexylsulfamate + H2O = cyclohexylamine + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62784", "l": "2 fonsecin B + H(+) + NADPH + O2 = bifonsecin B + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648268", "l": "HTR1A binds HTR1A antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170986", "l": "Ral-GDS binds to Ras-GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3065959", "l": "An unknown protease degrades hCBXs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58959", "l": "a ribonucleotide in RNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19265", "l": "carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.108", "l": "\"carnitine 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67537", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46702", "l": "(R)-lipoyl-GMP + diphosphate => (R)-lipoate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43094", "l": "2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2479) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26113", "l": "H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12182", "l": "H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine => anthranilate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46354", "l": "3-hydroxydecanoyl-CoA => (2E)-decenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52762", "l": "(Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate => (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59088", "l": "D-histidine + S-adenosyl-L-methionine = (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.152", "l": "\"D-histidine 2-aminobutanoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62339", "l": "AMP + ATP <=> adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191654", "l": "c-src associates with Cx43 in gap junctions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790038", "l": "Expression of HSP90B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55273", "l": "11-cis-retinol + tetradecanoyl-CoA => 11-cis-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419644", "l": "Transphosphorylation of pLIMK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20004", "l": "glycolaldehyde + H2O + NAD(+) <=> glycolate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933528", "l": "Interaction of MEKK1 with TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645481", "l": "TIFA oligomerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031720", "l": "haptoglobin binding", "d": ["Binding to a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390598", "l": "Myosin Binds ATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9648017", "l": "EML4 binds to microtubules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48070", "l": "ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate => ganglioside GM2 (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30914", "l": "a sphingomyelin + H2O <=> a carboxylate + sphing-4-enine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68204", "l": "1,2-dihexanoylglycerol + octadecanoyl-CoA = 1,2-dihexanoyl-3-octadecanoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49184", "l": "chlorophyllide a + H(+) + H2O = 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol", "d": []}, {"i": "EC:3.1.1.100", "l": "\"chlorophyllide a hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352268", "l": "Cleavage of Satb1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888589", "l": "Release of GABA at the synapse (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75725", "l": "(10S)-hydroxy-(12Z)-octadecenoate => (9Z,12Z)-octadecadienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15405", "l": "(3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) = [(3R)-hydroxybutanoate](n+1) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44379", "l": "a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) <=> a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390674", "l": "ADRB1 bind ADR,NAd (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62794", "l": "2 H2O + NADP(+) + nigerone => 3 H(+) + NADPH + O2 + 2 rubrofusarin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61698", "l": "AMP + diphosphate + glycyl-[peptidyl-carrier protein] => ATP + glycine + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55156", "l": "a quinone + glutathione + H(+) + hydrogen sulfide = a quinol + S-sulfanylglutathione", "d": []}, {"i": "EC:1.8.5.8", "l": "\"eukaryotic sulfide quinone oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48010", "l": "2,5-dihydroxybenzoyl-CoA + H2O + NAD(+) => 2-hydroxybenzoyl-CoA + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990714", "l": "hydroxyproline O-galactosyltransferase activity", "d": ["Catalysis of the transfer of galactose from UDP-galactose to hydroxyproline residues present in the peptide backbone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617485", "l": "HOXB2 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69935", "l": "guanosine(out) + Na(+)(out) = guanosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31356", "l": "dimethyl sulfide + H(+) + NADH + O2 => formaldehyde + H2O + methanethiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015533", "l": "shikimate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: shikimate(out) + H+(out) = shikimate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173636", "l": "Formation of classic pathway C5 convertase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682863", "l": "RNF168 binds DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70325", "l": "2-carboxy-L-lyxonolactone => 2,3-dioxo-L-gulonate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043895", "l": "cyclomaltodextrin glucanotransferase activity", "d": ["Catalysis of the cyclization of part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730862", "l": "Autophosphorylation of LYN kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42774", "l": "N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682020", "l": "MRN complex binds shortened telomeres (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33783", "l": "1(F)-beta-D-fructosylsucrose + sucrose = 1,6-kestotetraose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57928", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate", "d": []}, {"i": "EC:6.3.5.13", "l": "\"lipid II isoglutaminyl synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609728", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN3B (GRIN3B) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60370", "l": "urate(in) => urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004360", "l": "glutamine-fructose-6-phosphate transaminase (isomerizing) activity", "d": ["Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090736", "l": "MATH domain binding", "d": ["Binding to a meprin and TRAF homology (MATH) domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54892", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide = [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.135", "l": "\"GDP-6-deoxy-D-talose 4-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.71", "l": "\"alcohol dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46761", "l": "2,4-dinitrotoluene + NADH + O2 => 4-methyl-5-nitrocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73964", "l": "(2E,6E)-farnesyl diphosphate => aristolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709109", "l": "DHFR dimer binds DHFR inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66272", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354124", "l": "Phosphorylation of pPTK2 by SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3785768", "l": "MRN complex binds DNA double strand breaks (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75727", "l": "(10E,12Z)-octadecadienoate + H2O = (10S)-hydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60033", "l": "8-oxo-GTP + H2O => 8-oxo-GDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10027", "l": "L-lysyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033420", "l": "CUG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CUG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46218", "l": "3beta-hydroxypregn-4-ene-20-one + NADP(+) => H(+) + NADPH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40664", "l": "L-serine => 2-aminoprop-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17352", "l": "(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29515", "l": "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.132", "l": "\"GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50834", "l": "17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48269", "l": "4',4'-dihydroxyechinenone => canthaxanthin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010348", "l": "lithium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17608", "l": "ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine <=> ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58973", "l": "H2O + O2 + vanillin => H(+) + H2O2 + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20428", "l": "2-oxoglutarate + ATP + hydrogencarbonate <=> (S)-oxalosuccinate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848338", "l": "PNPLA4 hydrolyzes TAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044104", "l": "2,5-dioxovalerate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: 2,5-dioxopentanoate + NAD+ + H2O = 2-oxoglutarate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44324", "l": "1-butyrylglycerol + H2O = butanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20316", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP <=> 1D-myo-inositol hexakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685838", "l": "CX3 complex binds D-loop structures (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36879", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0043733", "l": "DNA-3-methylbase glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 3-methylbase + H2O = DNA with abasic site + 3-methylbase. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylpurine or 3-methylpyrimidine base and the deoxyribose sugar to remove the methylated base, leaving an apurinic or apyrimidinic site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34263", "l": "dimethylallyl diphosphate + fumigaclavine A = diphosphate + fumigaclavine C", "d": []}, {"i": "EC:2.5.1.100", "l": "\"fumigaclavine A dimethylallyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032267", "l": "tRNA(Ile)-lysidine synthase activity", "d": ["Catalysis of the ligation of lysine onto the cytidine residue present at the wobble position (usually position 34) of an AUA-specific isoleucine tRNA, to form the derivative lysidine. This modification converts both the codon specificity of tRNA(Ile) from AUG to AUA and its amino acid specificity from methionine to isoleucine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69950", "l": "3-dehydro-6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75420", "l": "(R,S)-butane-2,3-diol + NAD(+) => (S)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71209", "l": "iodide(in) + 2 Na(+)(in) => iodide(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35793", "l": "H(+) + kanamycin X + UDP => 2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106262", "l": "1-acylglycerophosphoethanolamine O-acyltransferase activity", "d": ["Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA."]}, {"i": "RHEA:32995", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}, {"i": "EC:2.3.1.n7", "l": "\"1-acylglycerophosphoethanolamine O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71311", "l": "chloride(out) + L-alanine(out) + 2 Na(+)(out) = chloride(in) + L-alanine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197963", "l": "DHFR2 reduces FOLA to DHF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58742", "l": "diphosphate + H(+) + psi-UMP => H2O + psi-UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68911", "l": "ATP + H(+) + NADPH + picolinate <=> AMP + diphosphate + NADP(+) + picolinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52766", "l": "(E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75260", "l": "isoorientin + O2 => 3'-dehydroisoorientin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62475", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052861", "l": "glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group", "d": ["Catalysis of the endohydrolysis of (1->3)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55997", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65836", "l": "AH2 + ATP + 2 Co(II)-[trimethylamine-specific corrinoid protein] + H2O = A + ADP + 2 Co(I)-[trimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430190", "l": "p-SLP-76 binds NCK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16963", "l": "5-oxo-L-proline + L-lysine => epsilon-(gamma-L-glutamyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39075", "l": "(2E)-dodecenedioyl-CoA + H2O = (3S)-hydroxydodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0004737", "l": "pyruvate decarboxylase activity", "d": ["Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005010", "l": "insulin-like growth factor receptor activity", "d": ["Combining with insulin-like growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50427", "l": "(8Z,11Z,14Z)-eicosatrienoate + 2 O2 <=> prostaglandin G1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.41", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83791", "l": "Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72536", "l": "H2O + NADP(+) + vanillin => 2 H(+) + NADPH + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032601", "l": "FYN-mediated phosphorylation of GRIN2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086061", "l": "voltage-gated sodium channel activity involved in bundle of His cell action potential", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.32", "l": "\"17alpha-hydroxyprogesterone deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71283", "l": "chloride(out) + L-glutamine(out) + 2 Na(+)(out) = chloride(in) + L-glutamine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9698844", "l": "MLKL binds HSP90:CDC37 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051746", "l": "thalianol synthase activity", "d": ["Catalysis of the cyclization of 3(S)-oxidosqualene to (3S,13S,14R)-malabarica-8,17,21-trien-3-ol (thalianol)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58261", "l": "H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] => ADP-D-ribose + L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9770145", "l": "Formation of the Spliceosomal Bact complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8862380", "l": "HSD17B13 binds lipid droplets (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15438", "l": "a long-chain fatty aldehyde + CoA + NADP(+) => a long-chain fatty acyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380272", "l": "Plk1-mediated phosphorylation of Nlp (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000297", "l": "spermine transmembrane transporter activity", "d": ["Enables the transfer of spermine from one side of a membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41308", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67908", "l": "a primary linear alkyl sulfate ester + H2O = a primary alcohol + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.21", "l": "\"linear primary-alkylsulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23729", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 => A + H2O + prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.84", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17848", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39582", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA <=> (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28740", "l": "Cd(2+)(in) + H(+)(out) => Cd(2+)(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49544", "l": "(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O = 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52957", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate => hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158357", "l": "factor XIIa binds SERPING1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0005499", "l": "vitamin D binding", "d": ["Binding to vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64407", "l": "carnosine(out) + H(+)(out) <=> carnosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16982", "l": "3-oxoadipate + NAD(+) => H(+) + maleylacetate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63132", "l": "apo-[alkylcobalamin reductase] + glutathione + methylcob(III)alamin = cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-methyl glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086077", "l": "gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from an AV node cell to a bundle of His cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70971", "l": "D-dopa + H2O + O2 = 3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.46", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58815", "l": "ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate <=> AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938356", "l": "RMB14 binds RUNX2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987043", "l": "IL22RA1 binds JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39578", "l": "3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33907", "l": "4-(methylamino)butanoate + H2O + O2 = 4-aminobutanoate + formaldehyde + H2O2", "d": []}, {"i": "EC:1.5.3.19", "l": "\"4-methylaminobutanoate oxidase (formaldehyde-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45483", "l": "gamma-hexachlorocyclohexane <=> (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047240", "l": "lactosylceramide beta-1,3-galactosyltransferase activity", "d": ["Catalysis of the reaction: D-galactosyl-(1->4)-beta-D-glucosyl-R + UDP-D-galactose = D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38491", "l": "2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196857", "l": "PANK2 phosphorylates PanK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607747", "l": "TRAF6 binds MALT1 oligomers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53354", "l": "H(+) + NADH + uridine(20b) in tRNA => 5,6-dihydrouridine(20b) in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19366", "l": "ATP + D-ribulose 5-phosphate => ADP + D-ribulose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174097", "l": "Association of Emi1 with Cdh1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19907", "l": "dehydrospermidine + H(+) + NADH => NAD(+) + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174224", "l": "Dissociation of Cdc20 from APC/C complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22962", "l": "calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => formononetin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56931", "l": "abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38205", "l": "19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59640", "l": "D-xylotetraose + O2 = D-xylotetraono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-606349", "l": "Mis18 complex binds the centromere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626938", "l": "Beta-catenin binds SOX proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675834", "l": "PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50255", "l": "an acyl-CoA + H(+) + malonyl-CoA <=> a 3-oxoacyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22533", "l": "(2E)-octenedioyl-CoA + H2O => (3S)-hydroxyoctanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008267", "l": "poly-glutamine tract binding", "d": ["Binding to a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11236", "l": "putrescine + spermidine = propane-1,3-diamine + sym-homospermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696670", "l": "CHD1L is recruited to GG-NER site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43743", "l": "ATP + CoA + hexanoate <=> AMP + diphosphate + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140853", "l": "cholesterol-protein transferase activity", "d": ["Catalysis of the transfer of a cholesterol to an acceptor protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47515", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isocholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379387", "l": "COMT transfers Met to DA to form 3MT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013157", "l": "CDC42 binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71641", "l": "K(+)(out) + Na(+)(out) => K(+)(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799097", "l": "ATM phosphorylates ZNF420 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48501", "l": "H2O + octanoylglycerol => glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.93", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0019120", "l": "hydrolase activity, acting on acid halide bonds, in C-halide compounds", "d": ["Catalysis of the hydrolysis of any acid halide bond in substances containing halogen atoms in organic linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614605", "l": "Persulfide sulfur is dioxygenated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70509", "l": "dimethylallyl phosphate + H(+) + phosphate => dimethylallyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3341294", "l": "Superoxide reduces cytochrome c (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22707", "l": "2 H2O + ricinine <=> 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50775", "l": "H2O + nitroethane + O2 <=> acetaldehyde + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102146", "l": "tricetin O-methytransferase activity", "d": ["Catalysis of the reaction: tricetin + S-adenosyl-L-methionine = H+ + 3'-O-methyltricetin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850786", "l": "SPINK6 binds KLK12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29226", "l": "menaquinone-8 + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.45", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19637", "l": "D-nopaline + H2O + NADP(+) = 2-oxoglutarate + H(+) + L-arginine + NADPH", "d": []}, {"i": "EC:1.5.1.19", "l": "\"D-nopaline dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044600", "l": "protein guanylyltransferase activity", "d": ["Catalysis of the reaction: GTP + protein = diphosphate + guanylyl-protein; mediates the addition of an guanylyl (guanosine 5'-monophosphate; GMP group) to specific residues of target proteins."]}, {"i": "REACT:R-HSA-9765952", "l": "nsp12 guanylates nsp7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114354", "l": "SMAC binds XIAP:Caspase-7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22239", "l": "2-deoxy-D-glucose 6-phosphate + H2O <=> 2-deoxy-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798374", "l": "DYRK2 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67315", "l": "(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one <=> myceliothermophin E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63538", "l": "bradykinin(1-7) + L-phenylalanine => bradykinin(1-8) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12981", "l": "H2O + O2 + S-sulfanylglutathione = glutathione + 2 H(+) + sulfite", "d": []}, {"i": "EC:1.13.11.18", "l": "\"persulfide dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.99", "l": "\"fatty acid amide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58219", "l": "A + dihydroserpentine <=> AH2 + serpentine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417908", "l": "P2RY1 binds ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21884", "l": "H2O + trithionate = H(+) + sulfate + thiosulfate", "d": []}, {"i": "EC:3.12.1.1", "l": "\"trithionate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29533", "l": "a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40964", "l": "4 2-aminophenol + 3 O2 => 2 2-aminophenoxazin-3-one + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42110", "l": "H(+) + NADH + progesterone => (20S)-hydroxypregn-4-en-3-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62480", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17438", "l": "2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate => (2E,4E)-2,4-dichloromuconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015599", "l": "ATPase-coupled L-glutamine transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glutamine(out) -> ADP + phosphate + glutamine(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183072", "l": "EGFR non-clathrin mediated endocytosis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700647", "l": "Active ALK phosphorylates SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22703", "l": "gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37958", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874080", "l": "SRC phosphorylates PTK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45812", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.134", "l": "\"very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-481009", "l": "Exocytosis of platelet dense granule content (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65669", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54634", "l": "2-hydroxytetradecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35237", "l": "H(+)(in) + tetracycline(out) => H(+)(out) + tetracycline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212356", "l": "Formation of CSL-NICD coactivator complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9732729", "l": "Activated JAK1 binds RAF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730856", "l": "Autophosphorylation of PAK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417927", "l": "P2Y2 receptor binds ATP and UTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74059", "l": "PDE6 hydrolyses cGMP to GMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37356", "l": "H2O + uridine 2'-phosphate => phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374662", "l": "Translocation of Ezrin to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65440", "l": "a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-844619", "l": "AIM2 binds dsDNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35484", "l": "5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine => 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28236", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O => L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222237", "l": "SMYD2 methylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5205649", "l": "p62 links damaged mitochondria to LC3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114264", "l": "Translocation of activated BAX to the mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47383", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030060", "l": "L-malate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211968", "l": "CYP2W1 oxidises INDOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52337", "l": "a long-chain fatty acid + ATP + H(+) => a long-chain fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71964", "l": "(R)-2-hydroxyglutarate(out) + 3 Na(+)(out) => (R)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45863", "l": "12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18315", "l": "benzaldehyde + hydrogen cyanide => (R)-mandelonitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64640", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose = lactose + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446322", "l": "PARVA associates with Paxillin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25342", "l": "H2O + urea = carbamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22966", "l": "CO2 + putrescine => H(+) + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71813", "l": "3,3',5-triiodo-L-thyronine(in) => 3,3',5-triiodo-L-thyronine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004329", "l": "formate-tetrahydrofolate ligase activity", "d": ["Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798749", "l": "Exocytosis of specific granule lumen proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23036", "l": "2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964759", "l": "Alternative endo-mannosidase I route (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052878", "l": "linoleate 8R-lipoxygenase activity", "d": ["Catalysis of the reaction: O2 + linoleate = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211960", "l": "CYP2U1 19-hydroxylates ARA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061770", "l": "translation elongation factor binding", "d": ["Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944457", "l": "MAF1 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0019888", "l": "protein phosphatase regulator activity", "d": ["Binds to and modulates the activity of a protein phosphatase."]}, {"i": "REACT:R-HSA-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42464", "l": "biphenyl-2,2',3-triol + O2 = 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41966", "l": "(2E)-butenoyl-CoA + H2O2 => butanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018860", "l": "anthranilate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + anthranilate + CoA = AMP + diphosphate + anthranilyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53042", "l": "17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56948", "l": "pyruvate + UTP = H(+) + phosphoenolpyruvate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59733", "l": "biotinyl-5'-AMP + L-lysyl-[protein] => AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200406", "l": "CPT1A,B transfers PALM to CAR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64100", "l": "2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + TAN-1612", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61873", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 => 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54757", "l": "deamido-NAD(+) + hydrogencarbonate => AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692315", "l": "OX40L binds OX40 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.12", "l": "\"dihydrolipoyllysine-residue acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710101", "l": "CASP4, CASP5 cleave GSDMD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189406", "l": "4 PBGs bind to form HMB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854222", "l": "TBC1D3 associates with RAB5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64522", "l": "A + 3 CO2 + 4 CoA + H2O + orsellinaldehyde => acetyl-CoA + AH2 + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784204", "l": "JAKs bind OSMR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12858", "l": "(2S,3S)-3-methyl-L-aspartate => L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051287", "l": "NAD binding", "d": ["Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953398", "l": "PIR oxygenates quercetin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.212", "l": "\"endo-(1->4)-fucoidanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11624", "l": "2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate", "d": []}, {"i": "EC:2.6.3.1", "l": "\"oximinotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391913", "l": "FPR2 binds FPR2 ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69590", "l": "IMP + uridine => inosine + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37934", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20995", "l": "16-hydroxytabersonine + S-adenosyl-L-methionine <=> 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56265", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60069", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008467", "l": "[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22973", "l": "butanal + CoA + NADP(+) => butanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57373", "l": "H2O + NADPH => (6S)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390886", "l": "HRH4 binds Hist (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42784", "l": "adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.184", "l": "\"23S rRNA (adenine(2085)-N(6))-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102983", "l": "xylogalacturonan beta-1,3-xylosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-xylose + a homogalacturonan <=> UDP + 4 H+ + a xylogalacturonan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61783", "l": "keto-L-tagatose <=> keto-L-sorbose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75893", "l": "CoA + pseudomonic acid C--holothin => holothin + pseudomonoyl-CoA C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48604", "l": "2,3-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] = 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12606", "l": "D-glyceraldehyde 3-phosphate + H(+) + pyruvate => 1-deoxy-D-xylulose 5-phosphate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062187", "l": "anandamide 8,9 epoxidase activity", "d": ["Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]."]}, {"i": "RHEA:53140", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29069", "l": "CO2 + menaquinol-8 => formate + H(+) + menaquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42441", "l": "L-aspartate + NAD(+) => H(+) + iminosuccinate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13805", "l": "A + a 3-oxo-5alpha-steroid = a 3-oxo-Delta(4)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38461", "l": "2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA => 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001512", "l": "dihydronicotinamide riboside quinone reductase activity", "d": ["Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1170539", "l": "Prolactin receptor is internalized (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943279", "l": "GGT dimers hydrolyse GSH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44465", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050491", "l": "sulcatone reductase activity", "d": ["Catalysis of the reaction: NAD+ + sulcatol = H+ + NADH + sulcatone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632652", "l": "Hh-Npp binds CDON and PTCH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47880", "l": "dioctanoylglycerol + H2O = H(+) + octanoate + octanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10595", "l": "a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0016503", "l": "pheromone receptor activity", "d": ["Combining with a pheromone to initiate a change in cell activity. A pheromone is a substance used in olfactory communication between organisms of the same species eliciting a change in sexual or social behavior."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30181", "l": "2 CO2 + reduced 2[4Fe-4S]-[ferredoxin] => oxalate + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797803", "l": "PTPRD binds SLITRK1-6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684096", "l": "CDK2 phosphorylates RBBP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40036", "l": "ATP + L-glutamate + N-acetyl-L-aspartate => ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13292", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448957", "l": "Interaction of p38 MAPK with JLP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54385", "l": "a 3-oxo-5alpha-steroid + NADP(+) => a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45201", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19220", "l": "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane <=> 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13988", "l": "ATP + L-homoserine <=> ADP + H(+) + O-phospho-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062181", "l": "1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity", "d": ["Catatlysis of the reaction: calcitriol + 2 H+ + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]."]}, {"i": "RHEA:49192", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.349248930891576", "identifiers": [{"i": "GO:0030246", "l": "carbohydrate binding", "d": ["Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956639", "l": "RUNX1 binds YAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0062186", "l": "anandamide epoxidase activity", "d": ["Catalysis of the epoxidation of double bonds of the arachidonoyl moiety of anandamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218821", "l": "PDK1 phosphorylates PKC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658438", "l": "SPRED dimer binds NF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40310", "l": "A + decanedioyl-CoA <=> (2E)-decenedioyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32758", "l": "(2S)-naringenin + 2-oxoglutarate + O2 <=> apigenin + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23943", "l": "D-gluconate + NAD(+) <=> 5-dehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12113", "l": "indole-3-pyruvate + S-adenosyl-L-methionine => (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49273", "l": "alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] => calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004824", "l": "lysine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008448", "l": "N-acetylglucosamine-6-phosphate deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928624", "l": "EPHBs bind EFNBs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9612219", "l": "ERBB4s80 binds to SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030743", "l": "rRNA (adenosine-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing a single residue of 2'-O-methyladenosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31077", "l": "(2E)-dodecenoyl-CoA + H2O => (3S)-3-hydroxydodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34840", "l": "4 H(+) + 5 malonyl-CoA => 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022934", "l": "GAD1 gene expression is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59849", "l": "(2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH => (S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193641", "l": "IKK-beta is recruited (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20394", "l": "holo-[citrate lyase ACP] + S-acetylphosphopantotheine => (R)-4'-phosphopantetheine + acetyl-[citrate lyase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350450", "l": "RHO1:GTP complex dissociates from RHOGEF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16413", "l": "(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + L-lysyl-[glycine-cleavage complex H protein]", "d": []}, {"i": "EC:2.3.1.200", "l": "\"lipoyl amidotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74889", "l": "2',3'-cGAMP(out) + ADP + H(+) + phosphate => 2',3'-cGAMP(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28698", "l": "hydrogencarbonate(in) <=> hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32889", "l": "2 all-trans-retinal => all-trans-beta-carotene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25923", "l": "A + H2O + quinolin-7-ol <=> 7-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805981", "l": "HMGB1 release from cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67993", "l": "AH2 + trichloroethene => (Z)-1,2-dichloroethene + A + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39771", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001156", "l": "TFIIIC-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase III transcription factor belonging to the TFIIC complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709109", "l": "DHFR dimer binds DHFR inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34084", "l": "a (3R)-3-hydroxyacyl-CoA => a (3S)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51358", "l": "(9Z)-octadecenoate + L-glutamine => H2O + N-(9Z-octadecenoyl)-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48894", "l": "L-threonyl-[protein] + N-acetyl-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69512", "l": "H2O + N-acetyl-D-galactosamine + O2 = H(+) + H2O2 + N-acetyl-D-galactosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944216", "l": "Association of procollagen type XV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24662", "l": "H2O + N(omega)-hydroxy-L-arginine + NADP(+) => H(+) + L-arginine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204871", "l": "Interaction of Tie2 and Grb2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58663", "l": "a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-methionine <=> a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799761", "l": "TP53 binds PPP1R13L (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042913", "l": "group A colicin transmembrane transporter activity", "d": ["Enables the transfer of group A colicins (colicins E1, E2, E3, A, K, and N) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416562", "l": "p190RhoGAP binds Plexin-B1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109813", "l": "GRB2-1 binds SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611751", "l": "β1,2-agonists bind ADRB1,2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31423", "l": "(2Z,6E)-farnesyl diphosphate = (-)-alpha-cedrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52052", "l": "9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684836", "l": "CLEC1B dimer binds PDPN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.7", "l": "\"phosphopentomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948136", "l": "ULK1 Translocates to the mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727819", "l": "TAK1 phosphorylates MKK6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60035", "l": "8-oxo-GTP + H2O <=> 8-oxo-GDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62068", "l": "2-deoxy-D-glucose 6-phosphate + NADP(+) = 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43495", "l": "7(1)-hydroxychlorophyll a + NADP(+) <=> chlorophyll b + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63789", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604732", "l": "Autocatalytic activation of proMMP13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70738", "l": "chloride(out) + glycine betaine(out) + 2 Na(+)(out) <=> chloride(in) + glycine betaine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001863", "l": "collectin receptor activity", "d": ["Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31611", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene = H2O + rhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250606", "l": "botD LC cleaves target cell VAMP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018469", "l": "myrtenal dehydrogenase activity", "d": ["Catalysis of the reaction: myrtenal + H2O = 2 H+ + 2 e- + myrtenic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655348", "l": "Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681674", "l": "nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17203", "l": "2,5-dioxopentanoate + H2O => 2-dehydro-3-deoxy-L-arabinonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14282", "l": "2 Fe(III)-[cytochrome c] + H2O + sulfite => 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3782655", "l": "HDAC10 deacetylates histone (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35782", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> mutildienyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.74", "l": "\"glycosaminoglycan galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11307", "l": "(S)-ureidoglycolate <=> glyoxylate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39875", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12903", "l": "D-ornithine + urea => D-arginine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429036", "l": "SLC2A9 transports Fru, Glc, urate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73306", "l": "H(+)(in) + oxaloacetate(out) + phosphate(in) <=> H(+)(out) + oxaloacetate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63587", "l": "2-deoxyecdysone 22-phosphate + H2O <=> 2-deoxyecdysone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017084", "l": "delta1-pyrroline-5-carboxylate synthetase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65451", "l": "butanoyl-CoA + ethanol <=> CoA + ethyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61213", "l": "myricetin + UDP-alpha-D-glucose => H(+) + myricetin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72716", "l": "(R)-dihydrolipoate + ATP + H(+) => (R)-N(6)-dihydrolipoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985123", "l": "RNASEL binds 2'-5' oligoadenylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.127", "l": "\"1,6-alpha-L-fucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33661", "l": "H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+) => H(+) + N-tetracosanoylsphinganine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018661", "l": "orcinol 2-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + orcinol = 2,3,5-trihydroxytoluene + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9725855", "l": "NR3C2 binds NR3C2 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25577", "l": "3 O2 + protoporphyrinogen IX => 3 H2O2 + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798528", "l": "S100A8:S100A9 binds Mn2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61279", "l": "H2O + L-ornithine + O2 <=> 5-amino-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13341", "l": "a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047501", "l": "(+)-neomenthol dehydrogenase activity", "d": ["Catalysis of the reaction: (+)-neomenthol + NADP+ = (2S,5R)-menthone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49237", "l": "N(pros)-phospho-L-histidyl-[protein](out) + sucrose => L-histidyl-[protein] + sucrose 6(G)-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57612", "l": "20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH = 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1369028", "l": "ABCAs mediate lipid efflux (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22481", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) => 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023132", "l": "AURKB phosphorylates MECP2 at S423 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604451", "l": "NOTCH4 binds FLT4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55578", "l": "H(+) + psilocybin + S-adenosyl-L-homocysteine => 4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534359", "l": "CatSper Channel Mediated Calcium Transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428918", "l": "Dissociation of the TP:G13 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33404", "l": "ATP + L-threonine => diphosphate + L-threonyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45307", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50449", "l": "AH2 + prostaglandin G3 => A + H2O + prostaglandin H3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47198", "l": "a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75818", "l": "ATP + H2O + K(+)(in) <=> ADP + H(+) + K(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.77", "l": "\"semenogelase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56099", "l": "[protein]-C-terminal Gly-Gly + ATP + H(+) <=> [protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433415", "l": "Activation of RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610732", "l": "GSK3 phosphorylates p-GLI3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018623", "l": "benzoate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: benzoate + NADH + H+ + O2 = catechol + CO2 + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418874", "l": "Recruitment and activation of N-WASP by Cdc42 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38036", "l": "(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate => (4Z)-2-oxohept-4-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73764", "l": "2 ATP + L-alanine + L-tryptophan => 2 ADP + cyclo(L-tryptophyl-L-alanyl) + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39500", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA => (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30215", "l": "a menaquinol + 2 nitric oxide = a menaquinone + H2O + nitrous oxide", "d": []}, {"i": "EC:1.7.5.2", "l": "\"nitric oxide reductase (menaquinol)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015275", "l": "stretch-activated, monoatomic cation-selective, calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156930", "l": "GTP-binding activates eEF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34569", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH => CDP-alpha-D-paratose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35913", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052875", "l": "riboflavin reductase (NAD(P)H) activity", "d": ["Catalysis of the reaction: reduced riboflavin + NAD(P)+ = riboflavin + NAD(P)H + 2 H+. This reaction can utilize NADH and NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681382", "l": "KIT mutants bind ripretinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43548", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53522", "l": "(9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16981", "l": "3-oxoadipate + NAD(+) = H(+) + maleylacetate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34347", "l": "(2E)-geraniol + NAD(+) = (2E)-geranial + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.347", "l": "\"geraniol dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64227", "l": "AH2 + O2 + uridine(34) in tRNA <=> 5-hydroxyuridine(34) in tRNA + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14913", "l": "AMP + thymidine = adenosine + dTMP", "d": []}, {"i": "EC:2.7.1.114", "l": "\"AMP--thymidine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30564", "l": "dimethylallyl diphosphate + L-tryptophan => 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67511", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-sn-glycero-3-phosphocholine <=> 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.85", "l": "\"limulus clotting factor B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373734", "l": "Nephrin interacts with Podocin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71683", "l": "2 H(+)(out) + L-aspartyl-glycine(out) = 2 H(+)(in) + L-aspartyl-glycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29976", "l": "2'-deoxycytidine(in) + H(+)(in) => 2'-deoxycytidine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26006", "l": "di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate = beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614933", "l": "ACEIs bind ACE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592278", "l": "Autocatalytic activation of proMMP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34512", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167597", "l": "Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627350", "l": "SMAC (DIABLO) binds XIAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371582", "l": "HSBP1 binds HSF1 trimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023351", "l": "DLL1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166542", "l": "beta-NGF dimer binds to TrkA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18741", "l": "10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA", "d": []}, {"i": "EC:2.3.1.166", "l": "\"2alpha-hydroxytaxane 2-O-benzoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.535054500181104", "identifiers": [{"i": "GO:0005548", "l": "phospholipid transporter activity", "d": ["Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047441", "l": "5-dehydro-2-deoxyphosphogluconate aldolase activity", "d": ["Catalysis of the reaction: 6-phospho-5-dehydro-2-deoxy-D-gluconate = 3-oxopropanoate + glycerone phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209840", "l": "Two DITs combine to form thyroxine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0051699", "l": "proline oxidase activity", "d": ["Catalysis of the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877360", "l": "RUNX1 binds the IFNG promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429441", "l": "SYK activation by SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60966", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP => (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-217255", "l": "FMO1:FAD N-oxidises TAM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34067", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate = diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate", "d": []}, {"i": "EC:2.4.2.45", "l": "\"decaprenyl-phosphate phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23885", "l": "nicotinamide + S-adenosyl-L-methionine => 1-methylnicotinamide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45577", "l": "(2R)-ethylmalonyl-CoA => (2S)-methylsuccinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52426", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73238", "l": "2,6-dichlorobenzoquinone + H2O <=> 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858252", "l": "HDLBP binds HDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9626817", "l": "PKC phosphorylates NCF1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68324", "l": "1D-myo-inositol 2,5-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73362", "l": "ATP + beta-alanine + dopamine <=> AMP + beta-alanyl-dopamine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70331", "l": "3-hydroxyphenylacetyl-CoA + H2O = 3-hydroxyphenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033444", "l": "AAG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AAG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247960", "l": "Activation of p38 MAPK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27593", "l": "(R)-pantoate + ATP + beta-alanine <=> (R)-pantothenate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49952", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate = 5,10-dihydrophenazine 1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12608", "l": "D-glyceraldehyde 3-phosphate + H(+) + pyruvate <=> 1-deoxy-D-xylulose 5-phosphate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64142", "l": "a fatty acid + L-asparagine => an N-(fatty acyl)-L-asparagine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20435", "l": "D-xylulose + H(+) + NADH => NAD(+) + xylitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033520", "l": "TYSND1 cleaves TYSND1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75234", "l": "H2O + L-galactono-1,4-lactone <=> H(+) + L-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2219524", "l": "PDPK1 binds PIP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027600", "l": "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34776", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) => a 3-oxosteroid + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68387", "l": "(2E,6E)-farnesyl diphosphate + L-tryptophyl-[protein] <=> (2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63784", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16745", "l": "AH2 + O2 + phylloquinone = 2,3-epoxyphylloquinone + A + H2O", "d": []}, {"i": "EC:1.14.99.20", "l": "\"phylloquinone monooxygenase (2,3-epoxidizing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38592", "l": "devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine => chloroorienticin B + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990028", "l": "intermediate voltage-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by an intermediate voltage-gated channel. An intermediate voltage-gated channel is a channel whose open state is dependent on intermediate voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30701", "l": "3-oxopropanoate + L-glutamate => 2-oxoglutarate + beta-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804425", "l": "TP53 binds POU4F2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58004", "l": "(20S)-ginsenoside F2 + UDP-alpha-D-glucose = (20S)-ginsenoside Rd + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0106075", "l": "peptide N-succinyltransferase activity", "d": ["Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: succinyl-CoA + peptide = CoA + N-succinylpeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341072", "l": "SUMOylation of RARA with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867613", "l": "PICALM binds R-SNAREs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16770", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate => (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052732", "l": "phosphoethanolamine phosphatase activity", "d": ["Catalysis of the reaction: O-phosphoethanolamine + H2O = ethanolamine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791156", "l": "Expression of TATDN2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021050", "l": "HSBP1 oligomer binds ESRs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102765", "l": "UDP-D-apiose synthase activity", "d": ["Catalysis of the reaction: H+ + UDP-alpha-D-glucuronate = UDP-alpha-D-apiose + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29574", "l": "H(+)(in) + L-idonate(in) <=> H(+)(out) + L-idonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20613", "l": "3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine = adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445084", "l": "Phosphorylation of L1 by SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781922", "l": "USP13 binds UFD1L:SKP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61085", "l": "(2S)-naringenin + 2-oxoglutarate + O2 => (2R,3R)-dihydrokaempferol + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58064", "l": "O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin = 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9690461", "l": "FKBP1A binds tacrolimus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981621", "l": "C3 convertases spontaneously dissociate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690395", "l": "SOX9 binds the SOX9 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52721", "l": "5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O => 5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667914", "l": "ALK binds ligand midkine (MDK) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41754", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57409", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) => 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74628", "l": "NADPH + 2 O2 + prefumagillin => acetaldehyde + fumagillin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015183", "l": "L-aspartate transmembrane transporter activity", "d": ["Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430183", "l": "NCK binds PAK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11197", "l": "5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide => alpha-ribazole 5'-phosphate + H(+) + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44310", "l": "1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43126", "l": "2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine => guanosine(10) in tRNA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37995", "l": "all-trans-nonaprenyl diphosphate + H(+) + homogentisate = 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate", "d": []}, {"i": "EC:2.5.1.117", "l": "\"homogentisate solanesyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44951", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O <=> 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103092", "l": "methylthioalkylmalate isomerase activity", "d": ["Catalysis of the reaction: 2-(7'-methylthio)heptylmalate <=> 3-(7'-methylthio)heptylmalate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66960", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose = beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.383", "l": "\"GDP-Man:alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und beta-1,4-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21829", "l": "H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23462", "l": "benzyl alcohol + cetraxate + H(+) => benzyl cetraxate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004120", "l": "photoreceptor cyclic-nucleotide phosphodiesterase activity", "d": ["Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-976768", "l": "Factor H binds to C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34334", "l": "H(+) + indole-3-pyruvate + NADPH + O2 <=> (indol-3-yl)acetate + CO2 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54651", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174124", "l": "Dephosphorylation of phospho-Cdh1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3785711", "l": "Telomere shortening during replicative exhaustion (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62073", "l": "D-galactose 6-phosphate + NADP(+) => 6-phospho-D-galactono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74242", "l": "phosphate + solabiose <=> alpha-D-glucose 1-phosphate + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47171", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) <=> 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69200", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[tubulin] + L-glutamate = ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[tubulin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853792", "l": "RET tyrosine phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38850", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433451", "l": "JAK2 binds to p-KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37747", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine = 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60576", "l": "coenzyme M + methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] = Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}, {"i": "EC:2.1.1.253", "l": "\"[methyl-Co(III) tetramethylammonium-specific corrinoid protein]:coenzyme M methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61198", "l": "CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => (E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445704", "l": "Calcium Binds Caldesmon (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675417", "l": "PEBP1 binds activated RAF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40443", "l": "6-deoxy-6-sulfo-D-fructose + ATP = 6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.184", "l": "\"sulfofructose kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0043120", "l": "tumor necrosis factor binding", "d": ["Binding to tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806974", "l": "MET dimers autophosphorylate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76105", "l": "(11R)-methyl carlactonoate + S-adenosyl-L-homocysteine => (11R)-carlactonoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450488", "l": "BRF1 Complex recruits RNA degradation activities (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70099", "l": "H(+) + o-quinone methide + peniphenone D = penilactone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373042", "l": "2-oxoglutarate (alpha-ketoglutarate) + CoASH + NAD+ => succinylCoA + CO2 + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865425", "l": "RUNX2 binds CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660980", "l": "p-S276-RELA binds RELB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061730", "l": "C-rich strand telomeric DNA binding", "d": ["Binding to C-rich, single-stranded, telomere-associated DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60929", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672162", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3814838", "l": "Defective GYG1 is not autoglucosyolated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33855", "l": "an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phosphophytoceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30554", "l": "acetyl-CoA + beta-D-glucose <=> 6-O-acetyl-beta-D-glucose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45105", "l": "6-demethylmitomycin A + S-adenosyl-L-methionine => mitomycin A + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15284", "l": "lathosterol <=> 5alpha-cholest-8-en-3beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33711", "l": "4-sulfomuconolactone + H2O = 2 H(+) + maleylacetate + sulfite", "d": []}, {"i": "EC:3.1.1.92", "l": "\"4-sulfomuconolactone hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61296", "l": "5-deoxy-alpha-D-ribose 1-phosphate = 5-deoxy-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10123", "l": "adenosine in double-stranded RNA + H(+) + H2O <=> inosine in double-stranded RNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201717", "l": "CSNK2-mediated phosphorylation of DVL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938930", "l": "RUNX1 binds ELF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35320", "l": "H(+) + malonyl-CoA + octadecanoyl-CoA => 3-oxoeicosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62269", "l": "(R)-2-hydroxy-3-methylbutyrate + NADP(+) => 3-methyl-2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53756", "l": "allodeoxycholoyl-CoA + cholate = allodeoxycholate + choloyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218811", "l": "DOCK180:ELMO binds CRK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72247", "l": "(R)-noradrenaline + S-adenosyl-L-methionine = (R)-normetanephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52558", "l": "3-dehydro-4-O-phospho-D-erythronate + ADP + H(+) => 3-dehydro-D-erythronate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71478", "l": "H2O + neurotensin <=> L-isoleucyl-L-leucine + neurotensin(1-11)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28983", "l": "nitrite(in) = nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42888", "l": "(R)-3-phosphomevalonate + ATP = (R)-3,5-bisphosphomevalonate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.186", "l": "\"mevalonate-3-phosphate 5-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47889", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66764", "l": "ATP + folate(in) + H2O = ADP + folate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63831", "l": "L-alanine + vanillin <=> pyruvate + vanillylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10457", "l": "acetyl-CoA + D-maltose => 1-O-acetylmaltose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191303", "l": "FDPS dimer transfers IPPP to GPP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380930", "l": "Phosphorylated AMPK binds AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938217", "l": "RUNX1 binds the SWI/SNF complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20777", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose => myo-inositol + stachyose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1222491", "l": "Lactoferrin scavenges iron ions (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54722", "l": "H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51197", "l": "chloride(out) + Na(+)(out) + serotonin(out) => chloride(in) + Na(+)(in) + serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374664", "l": "Phosphorylation and activation of Ezrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68410", "l": "2-oxosuberate + CO2 + NADH => (2R,3S)-iso(homo)3citrate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73213", "l": "H(+)(out) + sucrose(in) => H(+)(in) + sucrose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70938", "l": "L-lysine(in) <=> L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43486", "l": "1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47428", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) = 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042586", "l": "peptide deformylase activity", "d": ["Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21424", "l": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.238", "l": "\"12beta-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444433", "l": "Cho transports from the extracellular space to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34747", "l": "15-methylhexadecasphinganine + ATP = 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445064", "l": "Activation of Rac1 by VAV2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73200", "l": "maleate(in) + sulfate(out) => maleate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983150", "l": "Proteasomal cleavage of substrate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64918", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate => a 2'-deoxyribonucleoside 5'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31494", "l": "soyasaponin III + UDP-beta-L-rhamnose <=> H(+) + soyasaponin I + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227893", "l": "TRAF3/or TRAF6 ubiquitination within dsRNA:MDA5:IPS1:TRAF3/TRAF6 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351948", "l": "Mitochondrial recruitment of Drp1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848829", "l": "CBL autoubiquitinates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12973", "l": "AMP + ATP = 2 ADP", "d": []}, {"i": "EC:2.7.4.3", "l": "\"adenylate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21792", "l": "NADP(+) + propan-2-ol = acetone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.80", "l": "\"isopropanol dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12627", "l": "D-glucose + sinapoyl (S)-malate => (S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9615249", "l": "ARBs bind AGRT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21858", "l": "6-hydroxycyclohex-1-ene-1-carbonyl-CoA => cyclohexa-1,5-diene-1-carbonyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68914", "l": "DNA polymerase alpha:primase binds at the origin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49166", "l": "5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine => a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.137", "l": "\"ribitol-5-phosphate 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672951", "l": "Inactive RAFs bind YWHAB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36808", "l": "H(+) + malonyl-CoA + octacosanoyl-CoA => 3-oxo-triacontanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48656", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023030", "l": "MHC class Ib protein binding, via antigen binding groove", "d": ["Binding to a major histocompatibility complex class Ib molecules via the antigen binding groove."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35473", "l": "(+)-pisatin + H(+) + S-adenosyl-L-homocysteine => (+)-6a-hydroxymaackiain + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22137", "l": "7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 => chlorophyllide b + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42758", "l": "5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018600", "l": "alpha-pinene dehydrogenase activity", "d": ["Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + myrtenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112727", "l": "Serine phosphorylation of STATs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38513", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74723", "l": "Endosome acidification (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012835", "l": "GDIs block activation of RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769383", "l": "CBY1 binds beta-catenin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210662", "l": "Phosphorylated HOP is dephosphorylated by PTP61F isoform 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37397", "l": "1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102662", "l": "malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity", "d": ["Catalysis of the reaction: 3-oxopropanoate + coenzyme A(4-) + NAD(1-) <=> acetyl-CoA(4-) + carbon dioxide + NADH(2-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52204", "l": "butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.23", "l": "\"chloroacetanilide N-alkylformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70617", "l": "H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein] => hexadecanoyl-[ACP] + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63135", "l": "apo-[alkylcobalamin reductase] + glutathione + methylcob(III)alamin <=> cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-methyl glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046911", "l": "metal chelating activity", "d": ["The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51714", "l": "keto-D-fructose 6-phosphate => keto-D-tagatose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60631", "l": "AH2 + gluconapin + O2 <=> A + H2O + progoitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380949", "l": "AMPK is dephosphorylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35799", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64193", "l": "H2O + N-(9Z-octadecenoyl)-L-lysine => (9Z)-octadecenoate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49060", "l": "a long-chain alkane + FMNH2 + O2 = a long chain fatty alcohol + FMN + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.28", "l": "\"long-chain alkane monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390425", "l": "FAR1 reduces PalmCoA to HXOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021325", "l": "NOTCH3 coactivator complex and STAT1 bind HES1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56040", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63931", "l": "an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30880", "l": "H2O + NAD(+) + prop-2-ynal => 2 H(+) + NADH + propynoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72098", "l": "(S)-carnitine(out) + Na(+)(out) <=> (S)-carnitine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036068", "l": "Defective GUSB does not hydrolyse GlcA-β1,3-GlcNAc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62633", "l": "a hydroperoxide + 2 glutathione => an alcohol + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10345", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821486", "l": "HCFC1 binds SET1A complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60872", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O = a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49500", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64625", "l": "(2E)-geraniol + acetyl-CoA => (2E)-geranyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63666", "l": "H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) => (8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879362", "l": "AGER binds ERK1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60219", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140396", "l": "5'-hydroxyaverantin dehydrogenase activity", "d": ["Catalyzes the reaction: (1'S,5'S)-hydroxyaverantin + NAD+ <=> 5'-oxoaverantin + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14305", "l": "ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)", "d": []}, {"i": "EC:6.1.1.15", "l": "\"proline--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59343", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A <=> 1'-hydroxy-demethylspheroidene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15201", "l": "6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.108", "l": "\"6-hydroxymellein O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211960", "l": "CYP2U1 19-hydroxylates ARA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033908", "l": "beta-L-rhamnosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing beta-L-rhamnose residues in beta-L-rhamnosides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76456", "l": "O-atom dealkylation of dextromethorphan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034016", "l": "NTF3 binds NTRK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69604", "l": "UTP => 3',5'-cyclic UMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63176", "l": "(2S)-ibuprofenoyl-CoA = (2R)-ibuprofenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690152", "l": "USP5 cleaves polyubiquitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37766", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16919", "l": "2,3,6-trihydroxypyridine + H2O + NAD(+) => 2,6-dihydroxypyridine + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43045", "l": "hexadecasphinganine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.47", "l": "\"dapdiamide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50601", "l": "acetyl-CoA + N-terminal L-seryl-[histone H2A] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4093342", "l": "SDC2 multimerises (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35390", "l": "precorrin-7 + S-adenosyl-L-methionine <=> 2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162715", "l": "Reorientation of dolichyl phosphate D-mannose in the endoplasmic reticulum membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351849", "l": "Caspase-mediated cleavage of Etk (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701488", "l": "Active ALK phosphorylates JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66305", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide => a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56164", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine = (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75118", "l": "all-trans-13,14-dihydroretinol + NAD(+) <=> all-trans-13,14-dihydroretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47643", "l": "adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36622", "l": "2-hydroxydocosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72941", "l": "2 Na(+)(in) + propanoate(in) => 2 Na(+)(out) + propanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35411", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside] + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.215", "l": "\"anthocyanidin 3-O-glucoside 6''-O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56367", "l": "13-dihydrocarminomycin + H(+) + NADPH + O2 <=> carminomycin + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "54.542815643789396", "identifiers": [{"i": "GO:0022843", "l": "voltage-gated monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70640", "l": "H2O + N(6)-hexanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-hexanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62119", "l": "H2O + iminosuccinate <=> NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204364", "l": "ROBO1 binds SLIT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64960", "l": "dTDP + H2O = dTMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67677", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851888", "l": "MET binds SHC1-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379387", "l": "COMT transfers Met to DA to form 3MT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374680", "l": "L1 trans-homophilic interaction (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607733", "l": "BCL10 binds CARD9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16722", "l": "5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23853", "l": "catechol + O2 => cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45951", "l": "acetyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549364", "l": "Expression of SERPINE1 (PAI-1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65057", "l": "glycochenodeoxycholate + NADP(+) => 7-oxoglycolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0031683", "l": "G-protein beta/gamma-subunit complex binding", "d": ["Binding to a complex of G-protein beta/gamma subunits."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983144", "l": "Transport of Antigen peptide in to ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65865", "l": "5alpha-androst-1-ene-3,17-dione + A + H2O => 5alpha-androstan-1,3,17-trione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66540", "l": "7-dehydrocholesterol + A + H2O = AH2 + cholesta-5,7-dien-3beta,25-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392295", "l": "Gbeta:gamma recruits PI3K gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60043", "l": "H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate <=> (2E)-3-methylhex-2-enoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72811", "l": "L-arginine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) = L-arginine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75991", "l": "a dicarboxylate(in) + N-benzoylglycine(out) = a dicarboxylate(out) + N-benzoylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0030614", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide."]}, {"i": "EC:1.20.4.-", "l": "\"With disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50864", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56840", "l": "5-amino-2-hydroxybenzoate + O2 = (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)", "d": []}, {"i": "EC:1.13.11.86", "l": "\"5-aminosalicylate 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68547", "l": "(2Z,6Z)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54735", "l": "N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65500", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine", "d": []}, {"i": "EC:4.1.99.26", "l": "\"3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27944", "l": "NH4(+) + oxaloacetate => (3R)-3-hydroxy-D-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40251", "l": "4-O-methylrhodomycin D + H2O = 10-carboxy-13-deoxydaunorubicin + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31389", "l": "alpha-amyrin => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928625", "l": "PAKs autophosphorylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3134962", "l": "DHX36 binds DNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40335", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.71", "l": "\"adenosine-5'-diphospho-5'-[DNA] diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637638", "l": "esxA binds TLR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56595", "l": "a disubstituted aliphatic (S)-hydroxynitrile <=> a ketone + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868573", "l": "CDK5:p25 phosphorylates PRDX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64598", "l": "an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+) => a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29404", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 => 3-demethylubiquinol-8 + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61702", "l": "AMP + glycyl-[peptidyl-carrier protein] + H(+) => glycyl-5'-AMP + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47949", "l": "H2O + thiamine phosphate => phosphate + thiamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034009", "l": "isoprene synthase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate = diphosphate + isoprene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174171", "l": "Association of Cyclin A with the APC/C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70196", "l": "ATP + deamido-NAD(+) => ADP + H(+) + nicotinate-adenine dinucleotide 3'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612671", "l": "ERBB4 gene expression is stimulated by ERBB4s80:ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3134954", "l": "DHX9 binds DNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41204", "l": "1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8960973", "l": "RLBP1:11cRAL dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008792", "l": "arginine decarboxylase activity", "d": ["Catalysis of the reaction: L-arginine + H+ = agmatine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68359", "l": "H2O + N-acetyl-L-aspartyl-L-glutamate <=> L-glutamate + N-acetyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71778", "l": "acetoacetate(out) + H(+)(out) <=> acetoacetate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12310", "l": "2 H(+) + L-2-aminoadipate + NADH => (S)-2-amino-6-oxohexanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60519", "l": "L-tryptophan <=> D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72557", "l": "estrone 3-sulfate(in) + propanoate(out) => estrone 3-sulfate(out) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55801", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acyleicosasphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.651613913496419", "identifiers": [{"i": "GO:0016893", "l": "endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters."]}, {"i": "EC:3.1.30.-", "l": "\"Endoribonucleases active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3928619", "l": "PAK1 binds RAC1:GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641134", "l": "SMURF2 binds AXIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44613", "l": "3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49092", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939201", "l": "ESR dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30327", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9627369", "l": "SEPT4 binds XIAP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004533", "l": "exoribonuclease H activity", "d": ["Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62168", "l": "H2O + N,N'-diacetylchitobiose = acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine", "d": []}, {"i": "EC:3.5.1.136", "l": "\"N,N'-diacetylchitobiose non-reducing end deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863009", "l": "Influx of extracellular calcium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58073", "l": "a 4,5-didehydrojasmonate + H(+) + NADPH => a jasmonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688459", "l": "RIPK3 binds HSP90:CDC37 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-179417", "l": "Multiubiquitination of Nek2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080018", "l": "anthocyanin 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: an anthocyanin + UDP-D-glucose = an anthocyanin-5-O-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015274", "l": "organellar voltage-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1461971", "l": "Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727300", "l": "9b homodimer localizes to the mitochondrial outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32637", "l": "(6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102168", "l": "5-methyl-phenazine-1-carboxylate N-methyltransferase activity", "d": ["Catalysis of the reaction: phenazine-1-carboxylate + S-adenosyl-L-methionine <=> 5-methylphenazine-1-carboxylate + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018594", "l": "MECP2 binds LBR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-532632", "l": "TRAF6 binds to p-IRAK2 complexed with activated TLR7 or TLR21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54941", "l": "(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42549", "l": "uridine(746) in 23S rRNA => pseudouridine(746) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48627", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2 <=> (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951690", "l": "Formation of RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23570", "l": "(3Z)-decenoyl-[ACP] => (2E)-decenoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34716", "l": "15-methylhexadecasphing-4-enine + ATP => 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004118", "l": "cGMP-stimulated cyclic-nucleotide phosphodiesterase activity", "d": ["Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37807", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17099", "l": "enol-phenylpyruvate => 3-phenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36614", "l": "(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 <=> (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417820", "l": "P2Y9 receptor can bind to LPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655193", "l": "KIAA0101 double monoubiquitination (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75658", "l": "(9Z)-octadecenoate + O2 <=> (8R)-hydroperoxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10156", "l": "dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.101", "l": "\"dihydrochelirubine 12-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11341", "l": "5-guanidino-2-oxopentanoate + H(+) => 4-guanidinobutanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44705", "l": "a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730885", "l": "Recruitment of TEC kinases to p-SLP-76 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41979", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) <=> CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202168", "l": "Phosphorylation of ZAP-70 by Lck (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018573", "l": "2-aminophenol 1,6-dioxygenase activity", "d": ["Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785594", "l": "FANCD2 binds FANCI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38857", "l": "a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O => a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749494", "l": "IKBIP binds IKBKB and CHUK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22506", "l": "adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate => 3'-phosphoadenylyl sulfate + quercetin 3-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448708", "l": "IL24 binds to IL22RA1:JAK1:IL20RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944216", "l": "Association of procollagen type XV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.1", "l": "\"Physarum polycephalum ribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46500", "l": "2-oxoglutarate + O2 + UMP = CO2 + phosphate + succinate + uridine-5'-aldehyde", "d": []}, {"i": "EC:1.14.11.49", "l": "\"uridine-5'-phosphate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71780", "l": "4-methyl-2-oxopentanoate(out) + H(+)(out) => 4-methyl-2-oxopentanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685953", "l": "SIRT6 deacetylates RBBP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66638", "l": "(-)-alpha-acorenol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416516", "l": "GRK2 sequesters activated Gq (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635845", "l": "GLI proteins bind CDC73 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36309", "l": "3,4-dihydroxybenzaldehyde + acetyl-CoA => (E)-caffeoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67285", "l": "(2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione => (1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14655", "l": "a nucleoside 5'-phosphate + H(+) => a nucleoside 3',5'-cyclic phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182988", "l": "Sprouty lures CBL away from EGFR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33388", "l": "cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine => aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73557", "l": "(E,E)-piperate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E,E)-feruperate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39924", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35576", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] => (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70477", "l": "2 H(+) + N,N-dimethylsphing-4-enine + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51852", "l": "(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004359", "l": "glutaminase activity", "d": ["Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13575", "l": "[(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP => [(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001647", "l": "G protein-coupled cytokinin receptor activity", "d": ["Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698029", "l": "p-STAT5 dissociates from mutant FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15007", "l": "CO2 + gibberellin A8 + succinate => 2-oxoglutarate + gibberellin A1 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202947", "l": "Caspase mediated cleavage of APC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203700", "l": "eNOS translocation from Golgi to Caveolae (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-383190", "l": "HCO3- transport through ion channel (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35462", "l": "cholesterol + NAD(+) <=> cholest-5-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63313", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => 15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30011", "l": "ATP + beta-D-galactose(out) + H2O = ADP + beta-D-galactose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605724", "l": "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26142", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+) => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11227", "l": "ATP + 2 D-alanine <=> ADP + D-alanyl-D-alanine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701064", "l": "TRPV1 binds TRPV1 agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2995330", "l": "COX10 transforms heme to heme O (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695845", "l": "FLT3 mutant dimers:GRB2 bind SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30309", "l": "formaldehyde + H2O + NADP(+) + xanthine => 7-methylxanthine + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380234", "l": "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803890", "l": "SFN dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9821486", "l": "HCFC1 binds SET1A complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730858", "l": "Autophosphorylation of BTK/ITK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909718", "l": "Formation of p-STAT1 homodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52162", "l": "(Z)-phenylacetaldehyde oxime => (E)-phenylacetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40148", "l": "eicosanoyl-CoA + H2O => CoA + eicosanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40145", "l": "(9Z,12Z)-octadecadienoate + CoA + H(+) => (9Z,12Z)-octadecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28400", "l": "L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate => H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68633", "l": "3 H(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417908", "l": "P2RY1 binds ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16168", "l": "L-tryptophan + O2 <=> CO2 + H2O + indole-3-acetamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164967", "l": "Unknown carnitine exporter transports CAR from the cytosol to the extracellular space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68706", "l": "3alpha-hydroxyetiocholan-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876868", "l": "ECE1 cleaves EDN1(53-90) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428296", "l": "IGF2BP1 binds specific RNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70646", "l": "D-proline(out) + H(+)(out) <=> D-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25287", "l": "lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047170", "l": "glucarate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: D-glucarate + sinapoyl-CoA = 2-O-sinapoyl-D-glucarate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62250", "l": "chloroacetate + 2 H(+) + NADPH => chloroacetaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44582", "l": "2-all-trans-decaprenylphenol + CO2 => 4-hydroxy-3-all-trans-decaprenylbenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047616", "l": "acyl-CoA dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708866", "l": "pro-F2R binds vorapaxar (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68839", "l": "(2Z,6E)-farnesyl diphosphate <=> (6R,7S)-himachala-9,11-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30488", "l": "H(+) + N,N-dihydroxy-L-isoleucine => (1E,2S)-2-methylbutanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25982", "l": "albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (5S)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53867", "l": "3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+) <=> 7,12-dioxo-lithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60397", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O => Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62000", "l": "3 A + protoporphyrinogen IX = 3 AH2 + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110307", "l": "REV1 binds AP-dsDNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31810", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-guaiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071618", "l": "lysophosphatidylethanolamine acyltransferase activity", "d": ["Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidylethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858346", "l": "AMHR2 binds AMH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391936", "l": "EP1 receptor can bind PGE2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0031628", "l": "opioid receptor binding", "d": ["Binding to an opioid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48939", "l": "2-oxoglutarate + L-prolyl-[Skp1 protein] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0099186", "l": "structural constituent of postsynapse", "d": ["The action of a molecule that contributes to the structural integrity of a postsynapse."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419644", "l": "Transphosphorylation of pLIMK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43392", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 1,3-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34615", "l": "2-hydroxyethylphosphonate + O2 = H(+) + hydrogencarbonate + methylphosphonate", "d": []}, {"i": "EC:1.13.11.73", "l": "\"methylphosphonate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686930", "l": "RIPK3 is cleaved by CASP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48840", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72438", "l": "(E)-caffeoyl-AMP + CoA <=> (E)-caffeoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209738", "l": "VD3 binds GC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65974", "l": "a peptide antigen(out) + ADP + H(+) + phosphate => a peptide antigen(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33194", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21576", "l": "carnitine + H(+) = 2-methylcholine + CO2", "d": []}, {"i": "EC:4.1.1.42", "l": "\"carnitine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26513", "l": "H2O + L-prolinamide <=> L-proline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174070", "l": "Association of Cdh1 with the APC/C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47102", "l": "CoA + H(+) + taurocholate => choloyl-CoA + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51789", "l": "2-hydroxybenzoyl-5'-AMP + CoA => 2-hydroxybenzoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14389", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.149", "l": "\"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58564", "l": "15alpha-stemmadenine + NADP(+) = 15alpha-stemmadenine intermediate II + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11359", "l": "A + H(+) + NADH <=> AH2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39605", "l": "(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35901", "l": "1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674022", "l": "BRAP autoubiquitinates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24284", "l": "L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.11", "l": "\"aspartate-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.31", "l": "\"NAD(+)--protein-arginine ADP-ribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950063", "l": "IL12RB2 binds JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20460", "l": "D-arabinose + NAD(+) <=> D-arabinono-1,4-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008587", "l": "IL37, IL37(?-218) binds IL18BP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034075", "l": "arabidiol synthase activity", "d": ["Catalysis of the reaction: oxidosqualene + H2O = arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68267", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028533", "l": "NR1H2,3, NRIP1 bind the FASN gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.945916858897462", "identifiers": [{"i": "GO:0015932", "l": "nucleobase-containing compound transmembrane transporter activity", "d": ["Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24341", "l": "(R,R)-butane-2,3-diol + NAD(+) => (R)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21279", "l": "D-arabinitol + NADP(+) <=> D-xylulose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36252", "l": "(E)-ferulate + ATP + CoA => (E)-feruloyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29938", "l": "cytosine(in) + H(+)(in) <=> cytosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32463", "l": "glycine + 2 S-adenosyl-L-methionine = 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.156", "l": "\"glycine/sarcosine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322422", "l": "Beta-catenin recruits SMARCA4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9774496", "l": "PAX2 binds the LHX1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879459", "l": "F-actin capping protein is a heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53585", "l": "NAD(+) + resolvin D2 => 7-oxoresolvin D2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76025", "l": "18-oxocortisol + 2 H2O + 2 oxidized [adrenodoxin] => 18-hydroxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51376", "l": "dopamine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoyl-dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54221", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene => all-trans-neurosporene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29344", "l": "L-aspartate(in) + succinate(out) => L-aspartate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757954", "l": "N4BP1 binds IKBKG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42922", "l": "H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(1498) in 16S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047667", "l": "AMP-thymidine kinase activity", "d": ["Catalysis of the reaction: AMP + thymidine = adenosine + thymidine 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879910", "l": "JAK2 is phosphorylated, activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168640", "l": "Ubiquitinated IkB is degraded (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944236", "l": "Association of procollagen type XIV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373734", "l": "Nephrin interacts with Podocin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50643", "l": "2-(2-methylsulfanyl)ethylmalate <=> 3-(2-methylsulfanyl)ethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31398", "l": "15-cis-4,4'-diapophytoene + FAD + H(+) <=> all-trans-4,4'-diapophytofluene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015021", "l": "heparin-sulfate lyase activity", "d": ["Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804276", "l": "ATM phosphorylates TTC5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68199", "l": "1,2-dihexanoylglycerol + tetradecanoyl-CoA <=> 1,2-dihexanoyl-3-tetradecanoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0016863", "l": "intramolecular oxidoreductase activity, transposing C=C bonds", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears."]}, {"i": "EC:5.3.3.-", "l": "\"Transposing C=C bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879311", "l": "mycothiol S-conjugate is cleaved into mercapturic acid and GlcN-Ins (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44136", "l": "dodecanoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl dodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0061135", "l": "endopeptidase regulator activity", "d": ["Binds to and modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0043404", "l": "corticotropin-releasing hormone receptor activity", "d": ["Combining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57735", "l": "A + all-trans-7,8-dihydroretinol <=> AH2 + all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30178", "l": "15-cis-phytoene + 2 plastoquinone-9 <=> 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769347", "l": "Activated glucocorticoid receptor binds NPAS4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174741", "l": "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624952", "l": "Assembly of the retrograde IFT train (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58915", "l": "ATP + H2O + iron(III) dicitrate(out) <=> ADP + H(+) + iron(III) dicitrate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72501", "l": "2-oxoglutarate(out) + prostaglandin E2(in) => 2-oxoglutarate(in) + prostaglandin E2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64501", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine => 3-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851919", "l": "Activated MET binds GAB1 and GRB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955844", "l": "RBKS phosphorylates ribose to R5P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389848", "l": "TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22152", "l": "a ubiquinone + D-glucose = a ubiquinol + D-glucono-1,5-lactone", "d": []}, {"i": "EC:1.1.5.2", "l": "\"quinoprotein glucose dehydrogenase (PQQ, quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647977", "l": "ICMT methylates S-Farn RAS proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55709", "l": "[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) => [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59421", "l": "H2O + methylamine + O2 => formaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942302", "l": "MMP13 cleaves OPTC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26303", "l": "(S)-allantoin + CO2 => 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64995", "l": "acetyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48487", "l": "a propanoate ester + H2O <=> an aliphatic alcohol + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785762", "l": "IL13RA1 binds TYK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69793", "l": "D-phenylalanine + H(+) + tRNA(Phe) => D-phenylalanyl-tRNA(Phe) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41614", "l": "D-ribose 2,5-bisphosphate + H(+) => alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035380", "l": "very long-chain-3-hydroxyacyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1364044", "l": "PRLR:JAK2 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130194", "l": "ABL phosphorylates WAVEs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36774", "l": "beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044584", "l": "cellodextrin binding", "d": ["Binding to a cellodextrin, a glucose polymer of 2 or more glucose monomers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13668", "l": "GTP <=> 3',5'-cyclic GMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73757", "l": "Binding of RRN3 to RNA Polymerase I (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39152", "l": "3-oxooctadecanoyl-CoA + H(+) + NADPH => (3R)-hydroxyoctadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10430", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755303", "l": "26S proteasome degrades HIFalpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928631", "l": "GIT1 binds bPIX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47048", "l": "a quinone + shikimate = 3-dehydroshikimate + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51233", "l": "2-glyceryl-prostaglandin H2 => 2-glyceryl-prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984964", "l": "IL12A gene transcription and translation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41587", "l": "dimethylallyl diphosphate + L-tyrosine <=> 4-O-dimethylallyl-L-tyrosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0032038", "l": "myosin II heavy chain binding", "d": ["Binding to a heavy chain of a myosin II complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68211", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol <=> 1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67520", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5591086", "l": "SERPINA5 binds activated protein C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72692", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) => 17beta-estradiol 17-O-(beta-D-glucuronate)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42459", "l": "4alpha-methylzymosterol <=> zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64822", "l": "2-phenylacetate + NH4(+) => 2-phenylacetamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043813", "l": "phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36797", "l": "a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate => a ribonucleoside 5'-triphosphate + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45323", "l": "H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine <=> H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428918", "l": "Dissociation of the TP:G13 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198714", "l": "ERK5 translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430311", "l": "Rsu-1 interacts with Pinch1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16578", "l": "ADP + ATP + H(+) => P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0033038", "l": "bitter taste receptor activity", "d": ["Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671737", "l": "p-T774-PKN1 binds CDC25C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30452", "l": "(S)-2,3-epoxysqualene => isomultiflorenol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120285", "l": "tyrosine sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of tyrosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46605", "l": "[HPr protein]-O-phospho-L-serine + H(+) + phosphate => [HPr protein]-L-serine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381608", "l": "cAMP activates EPAC2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193641", "l": "IKK-beta is recruited (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351434", "l": "Phosphorylation of H2AX at S139 by ATM at the site of DSB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54613", "l": "2-oxoglutarate + 3-methylbutanoyl-CoA + O2 => 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35242", "l": "tetracycline(in) <=> tetracycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28849", "l": "Li(+)(out) + melibiose(out) => Li(+)(in) + melibiose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53262", "l": "1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693356", "l": "CEMIP hydrolyses HA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42882", "l": "H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine => S-adenosyl 3-(methylsulfanyl)propylamine + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13210", "l": "A + 3 H2O + trithionate => AH2 + 4 H(+) + 3 sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710988", "l": "SARS-CoV-1 M protein interacts with TBK1/IKBKE  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13078", "l": "an acyl phosphate + D-hexose => a carboxylate + D-hexose phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54284", "l": "H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-octadecanoylsphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.53", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418553", "l": "cAMP degradation by Phosphodiesterases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10829", "l": "anthranilate + ATP + CoA => AMP + anthraniloyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005144", "l": "interleukin-13 receptor binding", "d": ["Binding to an interleukin-13 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75221", "l": "H(+) + L-fuconate => H2O + L-fucono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102562", "l": "hydroxyproline O-arbinofuranose transferase activity", "d": ["Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline = UDP + H+ + a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362549", "l": "Hh-Np traffics to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20357", "l": "3-phenylpropanoate + H(+) + NADH + O2 = 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21257", "l": "3-phosphoshikimate + phosphoenolpyruvate => 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0062037", "l": "D-loop DNA binding", "d": ["Binding to a DNA D-loop. A D-loop is a three-stranded DNA structure formed by the invasion of a single DNA strand that base pairs with one strand of duplex DNA, while the rest of the double-stranded DNA does not unwind."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68471", "l": "(2Z,6Z)-farnesyl diphosphate <=> (E)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57257", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP => GTP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176116", "l": "Recruitment and activation of Chk1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050159", "l": "orsellinate decarboxylase activity", "d": ["Catalysis of the reaction: o-orsellinate + H+ = CO2 + orcinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32079", "l": "(13E)-labda-7,13-dien-15-yl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.7", "l": "\"ferric-chelate reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047957", "l": "4'-methoxyisoflavone 2'-hydroxylase activity", "d": ["Catalysis of the reaction: formononetin + NADPH + O2 = 2'-hydroxyformononetin + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67316", "l": "(2S,4R)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine = (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67470", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine => H2O + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748991", "l": "XDH oxidises 6MP to 6TU (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102422", "l": "curcumin-4'-O-beta-D-gentiotrioside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: curcumin 4'-O-beta-D-gentiotrioside + UDP-alpha-D-glucose <=> curcumin 4'-O-beta-D-gentiotetraside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38110", "l": "2-dehydro-3-deoxy-L-galactonate <=> L-glyceraldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18887", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-beta-L-fucose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193702", "l": "Part of the ICD migrates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35523", "l": "H(+) + N-ethylmaleimide + NADPH = N-ethylsuccinimide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53793", "l": "benzylthiol + O2 => benzothialdehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58806", "l": "5'-ApG-3' + phosphate => 5'-pApG-3' + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13239", "l": "D-glucosamine 6-phosphate + L-glutamate => D-fructose 6-phosphate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19517", "l": "H2O + N,N-dimethylformamide = dimethylamine + formate", "d": []}, {"i": "EC:3.5.1.56", "l": "\"N,N-dimethylformamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31419", "l": "(2Z,6E)-farnesyl diphosphate = (-)-beta-curcumene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42175", "l": "(11Z)-eicosenoyl-CoA + AH2 + O2 <=> (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0004177", "l": "aminopeptidase activity", "d": ["Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395764", "l": "atREs binds to nascent CM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13146", "l": "4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate => alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9818574", "l": "TASP1 cleaves KMT2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0055056", "l": "D-glucose transmembrane transporter activity", "d": ["Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805205", "l": "GPR35 binds kynurenic acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983700", "l": "SYK binds the activated BCR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14021", "l": "AH2 + ecdysone + O2 = 20-hydroxyecdysone + A + H2O", "d": []}, {"i": "EC:1.14.99.22", "l": "\"ecdysone 20-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809707", "l": "MTMR12 binds MTMR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30294", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013435", "l": "RHOD auto-activates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42202", "l": "11-dehydrocorticosterone + H(+) + NADPH => corticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050235", "l": "pyridoxal 4-dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + pyridoxal = 4-pyridoxolactone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102234", "l": "but-1-en-3-one reductase activity", "d": ["Catalysis of the reaction: buten-2-one + NADPH + H+ <=> butan-2-one + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39545", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046575", "l": "rhamnogalacturonan acetylesterase activity", "d": ["Catalysis of the removal of acetylesters (as acetate) from galacturonic acid residues in the backbone of rhamnogalacturonan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66179", "l": "ATP + H2O + taurochenodeoxycholate 3-sulfate(in) <=> ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56496", "l": "gypsogenin + O2 + reduced [NADPH--hemoprotein reductase] = gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61066", "l": "beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442387", "l": "ZIP8 mediates zinc influx into cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71805", "l": "acetate(in) + H(+)(in) => acetate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632412", "l": "PTK2 is recruited to methylated ESR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168285", "l": "Clathrin-Mediated Pit Formation And Endocytosis Of The Influenza Virion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698924", "l": "B Nucleocapsid Assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27990", "l": "1-deoxy-D-xylulose + ATP = 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53045", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685604", "l": "SLAMF6 binds SLAMF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109702", "l": "PDPK1 phosphorylates AKT2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766532", "l": "SQSTM1 oligomer is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59997", "l": "3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein] => (E)-cinnamate + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64391", "l": "4 A + sn-3-O-phytanylglycerol 1-phosphate <=> 4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14101", "l": "[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O", "d": []}, {"i": "EC:1.14.99.29", "l": "\"deoxyhypusine monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47344", "l": "7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13730", "l": "FAD => AMP + H(+) + riboflavin cyclic-4',5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045521", "l": "interleukin-25 receptor binding", "d": ["Binding to an interleukin-25 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1297333", "l": "Association of Acrosin Heavy and Light Chain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38115", "l": "(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol = 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58384", "l": "NADP(+) + octan-1-ol = H(+) + NADPH + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1474266", "l": "Formation of collagen fibrils (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54607", "l": "2-oxoglutarate + decanoyl-CoA + O2 <=> 2-hydroxydecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10282", "l": "caffeine + H(+) + S-adenosyl-L-homocysteine => 1,7-dimethylxanthine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070041", "l": "rRNA (uridine-C5-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C5-methyluridine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25642", "l": "(1R,4S)-menthone + NADP(+) => (R)-pulegone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0003697", "l": "single-stranded DNA binding", "d": ["Binding to single-stranded DNA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101021", "l": "estrogen 2-hydroxylase activity", "d": ["Catalysis of the reaction: estrogen + donor-H2 + O2 = 2-hydroxyestrogen + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805507", "l": "APAF1 binds AVEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23973", "l": "(2E)-glutaconyl-CoA + H(+) + Na(+)(in) => (2E)-butenoyl-CoA + CO2 + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.96", "l": "\"4-aminobutyrate--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848414", "l": "Activated PTK6 binds CDKN1B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50543", "l": "prostaglandin A2 <=> prostaglandin C2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0016500", "l": "protein-hormone receptor activity", "d": ["Combining with a protein hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618093", "l": "ATP hydrolysis by HSP90 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247497", "l": "ERBB3 binds neuregulins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27358", "l": "iodide + S-adenosyl-L-methionine => iodomethane + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62508", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59780", "l": "L-histidine + S-adenosyl-L-methionine = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69259", "l": "H2O + progoitrin <=> (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691621", "l": "C5 binds C5 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75044", "l": "L-cystine(out) + L-leucine(in) => L-cystine(in) + L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17760", "l": "H(+) + L-methionine <=> 3-(methylsulfanyl)propanamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15889", "l": "H2O + L-glutamine = L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149519", "l": "MMACHC decyanates CNCbl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41726", "l": "(11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654569", "l": "Activated FGFR1 binds FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33201", "l": "butanal + H(+) + NADH => butan-1-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433456", "l": "Recruitment of STATs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102613", "l": "trimethyluric acid monooxygenase activity", "d": ["Catalysis of the reaction: 1,3,7-trimethyluric acid + O2 + NADH + 3 H+ <=> 1,3,7-trimethyl-5-hydroxyisourate + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36148", "l": "acetyl-CoA + benzyl alcohol => benzyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34094", "l": "(5R)-5-phosphooxy-L-lysine + H2O <=> (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18654", "l": "barbiturate + H2O => 3-oxo-3-ureidopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27308", "l": "1-pyrroline-2-carboxylate + AH2 => A + D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004170", "l": "dUTP diphosphatase activity", "d": ["Catalysis of the reaction: dUTP + H2O = dUMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18259", "l": "2 CO2 + 2 H2O + protoporphyrinogen IX => coproporphyrinogen III + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43804", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39244", "l": "(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51017", "l": "7,8-dihydroneopterin 3'-phosphate => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62813", "l": "4 monapinone A + O2 => 2 dinapinone A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30021", "l": "ADP + H(+) + lipid A-core => ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20393", "l": "holo-[citrate lyase ACP] + S-acetylphosphopantotheine = (R)-4'-phosphopantetheine + acetyl-[citrate lyase ACP]", "d": []}, {"i": "EC:2.3.1.49", "l": "\"deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66459", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49212", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31285", "l": "dihydroxyacetone phosphate + FADH2 => FAD + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39293", "l": "3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA => (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140799", "l": "glycine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + H+(in) = glycine(in) + H+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950271", "l": "sIL27RA translocates from the cytoplasm to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654399", "l": "Activated FGFR2 binds FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37370", "l": "CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine <=> 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31519", "l": "O2 + torulene = 3-methyl-2-butenal + 4'-apo-beta-carotenal", "d": []}, {"i": "EC:1.13.11.59", "l": "\"torulene dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52430", "l": "12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+) => 12-oxo-leukotriene B4 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986083", "l": "USP33 deubiquitinates ROBO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19245", "l": "N-phenylhydroxylamine = 2-aminophenol", "d": []}, {"i": "EC:5.4.4.1", "l": "\"(hydroxyamino)benzene mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39007", "l": "a cholesterol ester(in) = a cholesterol ester(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001972", "l": "retinoic acid binding", "d": ["Binding to retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73756", "l": "2 H(+)(out) + histamine(in) => 2 H(+)(in) + histamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28605", "l": "L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008709", "l": "cholate 7-alpha-dehydrogenase activity", "d": ["Catalysis of the reaction: cholate + NAD+ = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870461", "l": "RABGGTA and RABGGTB bind (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25250", "l": "H(+) + 2 pyruvate => (2S)-2-acetolactate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70043", "l": "6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19501", "l": "4-guanidinobutanoate + H2O = 4-aminobutanoate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69158", "l": "acrolein + N-(4-aminobutyl)-3-aminopropanal => spermine dialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014454", "l": "RHOG translocates to the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31475", "l": "soyasapogenol B + UDP-alpha-D-glucuronate = H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72722", "l": "eIF2 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4837364", "l": "Secretion of SOD3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45557", "l": "H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201622", "l": "Caspase-mediated cleavage of gelsolin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052725", "l": "inositol-1,3,4-trisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948066", "l": "K63polyUb-IRAK1 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0052841", "l": "inositol bisdiphosphate tetrakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: bisdiphospho-1D-myo-inositol tetrakisphosphate + H2O = diphospho-1D-myo-inositol pentakisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013109", "l": "RHOC GEFs activate RHOC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30433", "l": "taraxerol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162840", "l": "Reorientation of glucosaminyl-acyl-PI in the endoplasmic reticulum membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62571", "l": "H2O + S-benzyl-L-cysteinylglycine <=> glycine + S-benzyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71480", "l": "H2O + neurotensin => L-tyrosyl-L-isoleucyl-L-leucine + neurotensin(1-10)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13894", "l": "H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate => ADP + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36543", "l": "H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate", "d": []}, {"i": "EC:3.5.1.115", "l": "\"mycothiol S-conjugate amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49218", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388596", "l": "Melanocortin receptors bind melanocortins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72900", "l": "4-O-demethylbarbatate + S-adenosyl-L-methionine => proatranorin I + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017067", "l": "tyrosine-ester sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + L-tyrosine methyl ester = L-tyrosine methyl ester 4-sulfate + adenosine 3',5'-diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39762", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33473", "l": "a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010309", "l": "acireductone dioxygenase [iron(II)-requiring] activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-methylthio-2-oxobutanoate + formate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9724290", "l": "GNRHR2 binds GNRH1,2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54394", "l": "(9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174445", "l": "RPA binds to the Flap on the C-strand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67485", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050371", "l": "tyrosine phenol-lyase activity", "d": ["Catalysis of the reaction: L-tyrosine + H2O = NH4 + phenol + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74075", "l": "H(+) + NADH + phylloquinone = NAD(+) + phylloquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69396", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103048", "l": "tRNA m2A37 methyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + an adenine37 in tRNA <=> S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a 2-methyladenine37 in tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603419", "l": "Activated NTRK3 binds SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50373", "l": "an N-acylsphingoid base 1-phosphate(in) => an N-acylsphingoid base 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.9", "l": "\"selenate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74441", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + H(+)(in) => a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19644", "l": "(E)-4-coumarate + ATP + CoA <=> (E)-4-coumaroyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50620", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.343", "l": "\"UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004755", "l": "saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity", "d": ["Catalysis of the reaction: L-saccharopine + H2O + NADP+ = L-allysine + L-glutamate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49037", "l": "(-)-pluviatolide + S-adenosyl-L-methionine => (-)-bursehernin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373074", "l": "Receptor CCR9  binds CCL25 ligand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5220959", "l": "TDG excises 5-formylcytosine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15538", "l": "(2R)-3-sulfolactate + NADP(+) => 3-sulfopyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044605", "l": "phosphocholine transferase activity", "d": ["Catalysis of the reaction: CDP-choline + protein-serine = CMP + protein-serine-choline phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40383", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20388", "l": "(2R,3R)-dihydroquercetin + H(+) + NADH + O2 <=> (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390930", "l": "5-HT2 receptor can bind serotonin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380198", "l": "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28429", "l": "D-allulose 6-phosphate <=> keto-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174367", "l": "GCL ligates L-Glu to L-Cys (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51457", "l": "H2O + N-(9Z-octadecenoyl)-L-isoleucine => (9Z)-octadecenoate + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51612", "l": "(R)-2-hydroxyglutarate + oxaloacetate = (R)-malate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51965", "l": "2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28561", "l": "D-fructose 6-phosphate + H2O <=> D-fructose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72994", "l": "2 Na(+)(out) + scyllo-inositol(out) <=> 2 Na(+)(in) + scyllo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-688137", "l": "RIP2 is K63 polyubiquitinated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437932", "l": "p-Y348-SYK binds VAV family (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38263", "l": "(2R,3S)-beta-methylmalyl-CoA = 2-methylfumaryl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.148", "l": "\"2-methylfumaryl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24711", "l": "2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose => L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198621", "l": "AKT phosphorylates caspase-9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33252", "l": "2 sucrose => 6-kestotriose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72709", "l": "GDP-beta-L-fucose(out) + GMP(in) => GDP-beta-L-fucose(in) + GMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607751", "l": "TRAF6 oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40696", "l": "1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol => 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57407", "l": "NAD(+) + narcotine hemiacetal <=> H(+) + NADH + noscapine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71133", "l": "H(+)(out) + L-asparagine(in) + Na(+)(in) => H(+)(in) + L-asparagine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61747", "l": "steviolbioside + UDP-alpha-D-glucose <=> stevioside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749590", "l": "ASA- acetylates ALB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35875", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67079", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40978", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O <=> 2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59124", "l": "(S)-2,3-diaminopropanoate + ATP + citrate = 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate", "d": []}, {"i": "EC:6.3.2.54", "l": "\"L-2,3-diaminopropanoate--citrate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139893", "l": "Granzyme-B activates BID by cleavage (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66042", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.185", "l": "\"flavanone 7-O-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362427", "l": "Hh-Np binds GPC5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0022855", "l": "protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + glucose(out) = protein histidine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032556", "l": "pyrimidine deoxyribonucleotide binding", "d": ["Binding to a pyrimidine deoxyribonucleotide, any compound consisting of a pyrimidine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20915", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + taxa-4,11-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37865", "l": "1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050178", "l": "phenylpyruvate tautomerase activity", "d": ["Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40704", "l": "(9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate => 1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41998", "l": "globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP => globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61707", "l": "ATP + holo-[peptidyl-carrier protein] + L-serine <=> AMP + diphosphate + L-seryl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53836", "l": "a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19442", "l": "benzene-1,2,4-triol + O2 => 3-hydroxy-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59327", "l": "D-xylose + O2 <=> D-xylono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483087", "l": "PI is exchanged with PC by PITPNB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72189", "l": "H(+)(in) + sucrose(in) => H(+)(out) + sucrose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63800", "l": "GDP-alpha-D-mannose = GDP-beta-L-gulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48465", "l": "ganglioside GM1b + H2O => ganglioside GA1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168848", "l": "tBID binds to inactive BAK protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953037", "l": "E2F8 forms homodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65518", "l": "NH4(+) + pre-mycofactocin => 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32284", "l": "3-hydroxyanthranilate + O2 => H(+) + H2O + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35667", "l": "a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25824", "l": "H2O + O2 + spermine = H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25989", "l": "(5R)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68399", "l": "a percarboxylic acid + H2O <=> a carboxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51982", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O => an L-N,N-dihydroxypolyhomomethionine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12559", "l": "6-phospho-D-glucono-1,5-lactone + H2O <=> 6-phospho-D-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54045", "l": "(2E,6E)-farnesyl diphosphate + H2O => 7-epi-alpha-eudesmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20257", "l": "3-methyloxindole + NADP(+) = 3-methyleneoxindole + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.17", "l": "\"3-methyleneoxindole reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36335", "l": "D-glucuronate + H2O + NAD(+) = D-glucarate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614367", "l": "HCMV Nuclear Pore Docking (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102429", "l": "genistein-3-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: genistin + UDP-alpha-D-glucose <=> genistin 7-gentiobioside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191402", "l": "Reduction of presqualene diphosphate to form squalene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56873", "l": "(S)-N-acetyl-1-phenylethylamine + H2O => (S)-1-phenylethylamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702593", "l": "lestaurtinib-resistant FLT3 mutants don't bind lestaurtinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902118", "l": "calcidiol binding", "d": ["Binding to calcidiol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140696", "l": "factor V -> factor Va + factor V activation peptide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12951", "l": "2-dehydro-3-deoxy-D-fuconate + H2O => D-fuconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374173", "l": "AGT(34-41) binds to AGTR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156907", "l": "Aminoacyl-tRNA  binds to the ribosome at the A-site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051566", "l": "anthocyanidin-3-glucoside rhamnosyltransferase activity", "d": ["Catalysis of the reaction: anthocyanidin 3-glucoside + UDP-rhamnose = anthocyanidin 3-rutinoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.364", "l": "\"protopanaxadiol-type ginsenoside 3-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2089971", "l": "Secretion of collagens (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070251", "l": "pristanate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32474", "l": "demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] <=> (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69762", "l": "H2O + NAD(+) + nonanal <=> 2 H(+) + NADH + nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022141", "l": "Prolysyl oxidase activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72516", "l": "(R)-carnitine(out) + glutarate(in) => (R)-carnitine(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3159259", "l": "MMAA:MUT binds AdoCbl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54881", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one => (3R)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768764", "l": "REST binds promoter and the first intron of NPAS4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68660", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) 17-sulfate + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) 17-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13044", "l": "L-dopachrome <=> 5,6-dihydroxyindole-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.783030043623796", "identifiers": [{"i": "GO:0015926", "l": "glucosidase activity", "d": ["Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9010815", "l": "SLITs bind keratan sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855212", "l": "1/3-PP-IP5 transports from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28454", "l": "N(6)-(D-fructosyl)-L-lysine(in) = N(6)-(D-fructosyl)-L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070089", "l": "chloride-activated potassium channel activity", "d": ["Enables the chloride concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788061", "l": "Fibronectin degradation by ADAM8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54013", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730872", "l": "Activation of Calcineurin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0030554", "l": "adenyl nucleotide binding", "d": ["Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37223", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18786", "l": "A + gibberellin A12 aldehyde + H2O => AH2 + gibberellin A12 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66727", "l": "(S)-lactate + L-phenylalanine <=> H2O + N-[(S)-lactoyl]-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54335", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34978", "l": "(R)-pantothenate(in) <=> (R)-pantothenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296244", "l": "SUCNR1 binds SUCCA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004501", "l": "ecdysone 20-monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + Ecdysone + O2 = 20-hydroxyecdysone + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61796", "l": "holo-[peptidyl-carrier protein] + L-tryptophyl-5'-AMP = AMP + L-tryptophyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372542", "l": "Loading of dopamine into synaptic veiscles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23796", "l": "17-O-acetylnorajmaline + H2O = acetate + H(+) + norajmaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855047", "l": "Hydrolysis of internal thioester in C4b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60000", "l": "hydroxymethylphosphonate + O2 = formate + 2 H(+) + phosphate", "d": []}, {"i": "EC:1.13.11.89", "l": "\"(hydroxymethyl)phosphonate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40014", "l": "(+)-copalyl diphosphate + H2O <=> diphosphate + manool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196753", "l": "2xPPCS ligates PPanK with Cys (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183052", "l": "CBL binds to GRB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467811", "l": "Separation of sister chromatids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71866", "l": "taurodeoxycholate(out) <=> taurodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11712", "l": "3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.2.7.7", "l": "\"3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43250", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18003", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017159", "l": "pantetheine hydrolase activity", "d": ["Catalysis of the reaction: (R)-pantetheine + H2O = (R)-pantothenate + cysteamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64790", "l": "(E)-cinnamoyl-CoA + AMP + diphosphate => (E)-cinnamate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008763", "l": "UDP-N-acetylmuramate-L-alanine ligase activity", "d": ["Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009974", "l": "zeinoxanthin epsilon hydroxylase activity", "d": ["Catalysis of the reaction: zeinoxanthin + NADPH + O2 + H+ = lutein + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786155", "l": "POLN binds ICL-DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27516", "l": "phosphate + sphinganine => H2O + sphinganine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23277", "l": "2-dehydropantoate => 3-methyl-2-oxobutanoate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34741", "l": "H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine => H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004902", "l": "granulocyte colony-stimulating factor receptor activity", "d": ["Combining with granulocyte colony-stimulating factor (G-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57572", "l": "7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74378", "l": "H2O2(out) <=> H2O2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62096", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.55", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912394", "l": "NICD1 in complex with RBPJ (CSL) recruits MAML (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673789", "l": "Activated JNK phosphorylates c-JUN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18437", "l": "4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.148", "l": "\"4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693198", "l": "RHOD binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57653", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 => CMP + ganglioside GM1alpha + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858475", "l": "TNFSF9 binds TNFRSF9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30837", "l": "NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose => H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67642", "l": "ADP + dZDP => ATP + dZMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41761", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E)) => CMP + ganglioside GD3 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32482", "l": "2 iodide + L-tyrosine + 2 NADP(+) <=> 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805792", "l": "p-S291-PHF20 translocates to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964274", "l": "G alpha (12) binds BTK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869580", "l": "DEK binds TFAP2A homodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33588", "l": "acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate => CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14822", "l": "beta-L-arabinopyranose => L-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57348", "l": "3-hydroxy-4-methyl-L-kynurenine + H2O = 3-hydroxy-4-methylanthranilate + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30714", "l": "(S)-linalool <=> beta-myrcene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73212", "l": "H(+)(in) + sucrose(out) => H(+)(out) + sucrose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050318", "l": "tannase activity", "d": ["Catalysis of the reaction: digallate + H2O = 2 gallate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41917", "l": "H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] => 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22993", "l": "3-oxopropanoate + CoA + NAD(+) => acetyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71210", "l": "iodide(out) + 2 Na(+)(out) <=> iodide(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21359", "l": "L-arabinitol + NAD(+) <=> H(+) + L-ribulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004167", "l": "dopachrome isomerase activity", "d": ["Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399939", "l": "Autophosphorylation of PAK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033454", "l": "GCC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GCC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759158", "l": "SQSTM1 oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20867", "l": "alpha,alpha-trehalose 6-phosphate + phosphate <=> beta-D-glucose 1-phosphate + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004611", "l": "phosphoenolpyruvate carboxykinase activity", "d": ["Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634219", "l": "NUP93 recruits the Nup62 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.149", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018553", "l": "3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40046", "l": "ATP + citrate + L-glutamate <=> ADP + beta-citrylglutamate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.2", "l": "\"chymotrypsin C\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71849", "l": "glycoursodeoxycholate(in) => glycoursodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.098124162625822", "identifiers": [{"i": "GO:0042887", "l": "amide transmembrane transporter activity", "d": ["Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706323", "l": "Active FLT3 binds to SLA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53030", "l": "H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP => lithocholate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0106254", "l": "lipid sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of a lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75972", "l": "NADP(+) + neomorphine => H(+) + NADPH + neomorphinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47223", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64975", "l": "dUDP + H2O <=> dUMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61376", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31635", "l": "beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O = 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640862", "l": "Tankyrase binds AXIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010113", "l": "ADAM10:Zn2+ binds TSPANs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32077", "l": "(13E)-labda-7,13-dien-15-ol + diphosphate => geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806405", "l": "TP53 stimulates PMS2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170846", "l": "TGFBR2 recruits TGFBR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35914", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2213207", "l": "Formation of collagen networks (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67441", "l": "H2O + N(alpha)-acetyl-L-methionine => acetate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40651", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444691", "l": "Prokineticin receptors bind prokineticin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0045125", "l": "bioactive lipid receptor activity", "d": ["Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5333678", "l": "CPNEs bind PL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759147", "l": "NFE2L2 and MAFG bind the SQSTM1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12306", "l": "2 H(+) + L-2-aminoadipate + NADPH => (S)-2-amino-6-oxohexanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15165", "l": "H2O + O2 + sarcosine = glyoxylate + H2O2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0000700", "l": "mismatch base pair DNA N-glycosylase activity", "d": ["Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213208", "l": "Type X collagen associates with collagen type II fibrils (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44542", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57445", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.138", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161946", "l": "5S-HpETE is reduced to 5S-HETE by GPX1/2/4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17797", "l": "[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose = [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.29", "l": "\"cellulose synthase (GDP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204773", "l": "Interaction of Tie2 and Grb7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70974", "l": "D-dopa + H2O + O2 <=> 3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54933", "l": "(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] => (2E,9Z)-hexadecadienoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.-", "l": "\"With NADH or NADPH as one donor, and incorporation of one atom of oxygen\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10107", "l": "2-oxoglutarate + gibberellin A20 + O2 <=> CO2 + gibberellin A1 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097655", "l": "serpin family protein binding", "d": ["Binding to a member of the serpin protein family (serine protease inhibitors or classified inhibitor family I4). Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades. The majority of serpins inhibit serine proteases, but serpins that inhibit caspases and papain-like cysteine proteases have also been identified. Rarely, serpins perform a non-inhibitory function; for example, several human serpins function as hormone transporters and certain serpins function as molecular chaperones or tumor suppressors."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904769", "l": "isopentadecanoic acid binding", "d": ["Binding to isopentadecanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56315", "l": "3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O <=> 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10686", "l": "L-tyrosyl-[protein] + phosphate => H2O + O-phospho-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009401", "l": "RUNX2 binds SMURF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10508", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72921", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin II => 4-O-demethylbarbatate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45983", "l": "3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59662", "l": "D-cellotetraono-1,5-lactone + H2O2 => D-cellotetraose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57066", "l": "D-apionate + H(+) => D-apionolactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48546", "l": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine => [phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.50", "l": "\"tabersonine 3-oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43164", "l": "7-cyano-7-deazaguanine + guanosine(15) in tRNA = 7-cyano-7-carbaguanosine(15) in tRNA + guanine", "d": []}, {"i": "EC:2.4.2.48", "l": "\"tRNA-guanine(15) transglycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52213", "l": "acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60285", "l": "N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109702", "l": "PDPK1 phosphorylates AKT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018758", "l": "RHOH binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40693", "l": "1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754974", "l": "ADK phosphorylates RBV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72093", "l": "(R)-carnitine(in) + Na(+)(in) => (R)-carnitine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54337", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75707", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate = 10,11-epoxy-12-hydroxy-(14Z,17Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678843", "l": "ISGylation of protein translation regulator 4EHP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15057", "l": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30188", "l": "(S)-dihydroorotate + a quinone => a quinol + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63377", "l": "an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52836", "l": "H(+) + indole + NADH + O2 = H2O + indoxyl + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71629", "l": "phosphate(out) + succinate(in) => phosphate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445704", "l": "Calcium Binds Caldesmon (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008719", "l": "dihydroneopterin triphosphate 2'-epimerase activity", "d": ["Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40324", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416358", "l": "G alpha (q) inhibits PI3K alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9823816", "l": "OPTN binds CASP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193653", "l": "NGF homodimer binds to p75NTR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27734", "l": "4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate", "d": []}, {"i": "EC:3.5.1.n3", "l": "\"4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65805", "l": "a 5'-end L-tyrosylphosphate-2'-deoxynucleoside-DNA + H2O => a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+) + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671993", "l": "CIT-3 binds DLG4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391939", "l": "TP receptor can bind thromboxane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690023", "l": "NUBPL binds 4Fe-4S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15117", "l": "3'-dephospho-CoA + ATP = 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine", "d": []}, {"i": "EC:2.4.2.52", "l": "\"triphosphoribosyl-dephospho-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61827", "l": "pregnenolone + UDP-alpha-D-glucose <=> H(+) + pregnenolone 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3858475", "l": "ppDVL recruits RAC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706399", "l": "RHOBTB3 hydrolyzes ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668404", "l": "TNFA binds TNFR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928627", "l": "EPHB phosphorylates TIAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174119", "l": "Free APC/C phosphorylated by Plk1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58856", "l": "(6E)-8-hydroxygeraniol + NAD(+) = (6E)-8-oxogeraniol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.22", "l": "\"UMP kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376122", "l": "DSCAM/DSCAML1 homodimerization (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37855", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA = 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46349", "l": "(2E)-octenoyl-CoA + H2O => 3-hydroxyoctanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49471", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose <=> a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671702", "l": "AP1G2 binds HGS and CHMP2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28982", "l": "H(+)(out) + nitrite(in) <=> H(+)(in) + nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109639", "l": "Formation of the closed pre-initiation complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19813", "l": "a 2-oxocarboxylate + L-asparagine = 2-oxosuccinamate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33377", "l": "a 1-acyl-sn-glycero-3-phosphate + NADP(+) => a 1-acylglycerone 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70381", "l": "CoA + H(+) + N-tetradecanoyl-3-oxosphinganine => 3-oxosphinganine + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111238", "l": "Formation of ADAR2  homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29139", "l": "2 H(+)(in) + menaquinol-8 + nitrate = 2 H(+)(out) + H2O + menaquinone-8 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47058", "l": "4alpha-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4alpha-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50908", "l": "a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O", "d": []}, {"i": "EC:1.14.99.60", "l": "\"3-demethoxyubiquinol 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14065", "l": "scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O", "d": []}, {"i": "EC:4.2.1.44", "l": "\"myo-inosose-2 dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373732", "l": "Nephrin trans-homophilic interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.37", "l": "\"xylan 1,4-beta-xylosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684096", "l": "CDK2 phosphorylates RBBP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49571", "l": "2-glutathionyl-2-methylbut-3-en-1-ol <=> (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61237", "l": "H2O + L-methionine + O2 => 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610718", "l": "CK1 phosphorylates p-GLI2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70481", "l": "TPI1 isomerizes GA3P to DHAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852019", "l": "MET bound PI3K generates PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.10.1.-", "l": "\"Molybdenumtransferases or tungstentransferases with sulfide groups as acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.63", "l": "\"meprin B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53329", "l": "H2O + UDP-2,3-diacyl-alpha-D-glucosamine => 2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52169", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62923", "l": "1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol <=> 1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1170539", "l": "Prolactin receptor is internalized (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.23", "l": "\"S-methyl-5-thioribulose 1-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51809", "l": "(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60181", "l": "ATP + D-fructose(out) + H2O => ADP + D-fructose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31449", "l": "5-aminopentanoate + CO2 + H2O => 6-amino-2-oxohexanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56793", "l": "2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] => 2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202328", "l": "Translocation of PKC theta to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940554", "l": "MMP2 cleaves OPTC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20823", "l": "choline sulfate + H2O <=> choline + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71104", "l": "L-methionine(in) + S-methylmercury-L-cysteine(out) => L-methionine(out) + S-methylmercury-L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3782637", "l": "HDAC8 deacetylates histones (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16855", "l": "AMP + fumarate => N(6)-(1,2-dicarboxyethyl)-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67663", "l": "an (11Z)-eicosenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (8Z,11Z)-eicosadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669250", "l": "PAK1 phosphorylates FLNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25315", "l": "2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate = L-2-acetamido-6-oxoheptanedioate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033846", "l": "adenosyl-fluoride synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48611", "l": "A + a 2,3-saturated acyl-CoA <=> a 2,3-dehydroacyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9701147", "l": "TRPV1 binds TRPV1 blockers (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51389", "l": "acetyl-CoA + dopamine => CoA + H(+) + N-acetyl-dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52046", "l": "H(+) + mogroside IE + UDP => mogrol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58846", "l": "(6E)-8-oxogeranial + H(+) + NADH => (6E)-8-hydroxygeranial + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010428", "l": "methyl-CpNpG binding", "d": ["Binding to a methylated cytosine/unspecified/guanine trinucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798353", "l": "E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662613", "l": "MT3 exchanges zinc for copper (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73892", "l": "ATP + L-glutamate + spermidine => ADP + gamma-L-glutamylspermidine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48237", "l": "2 2-acetylphloroglucinol => 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418856", "l": "Activation of Rac1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67965", "l": "4-methylamino-L-phenylalanine + S-adenosyl-L-methionine => 4-dimethylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140662", "l": "ATP-dependent protein folding chaperone", "d": ["Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28783", "l": "H2O + L-cysteinylglycine = glycine + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71730", "l": "citrate(out) + fumarate(in) <=> citrate(in) + fumarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012689", "l": "IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40154", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990309", "l": "type-II dockerin domain binding", "d": ["Binding to a type-II dockerin domain of a protein. Type-II dockerin domain is the binding partner of type-II cohesin domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74377", "l": "H2O2(in) => H2O2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903089", "l": "5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity", "d": ["Enables the transfer of 5-amino-1-ribofuranosylimidazole-4-carboxamide from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.18.1", "l": "\"cathepsin X\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53773", "l": "chenodeoxycholate + lithocholoyl-CoA => chenodeoxycholoyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658430", "l": "NF1 is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45998", "l": "a 2-oxocarboxylate + a quinol + NH4(+) => a D-alpha-amino acid + a quinone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68340", "l": "(R)-4'-phospho-S-sulfopantetheine + H2O = (R)-S-sulfopantetheine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30008", "l": "ATP + H2O + L-arabinose(out) => ADP + H(+) + L-arabinose(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15812", "l": "(2E)-geranyl diphosphate + H2O <=> (R)-linalool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49912", "l": "(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433501", "l": "Interaction of other adapter proteins with p-KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28820", "l": "5-dehydro-D-gluconate(in) + H(+)(in) => 5-dehydro-D-gluconate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-606287", "l": "RSF complex binds the centromere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56126", "l": "AH2 + diphosphate + nonaflavuxanthin => A + all-trans-lycopene + dimethylallyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039660", "l": "structural constituent of virion", "d": ["The action of a molecule that contributes to the structural integrity of a virion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15624", "l": "an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27387", "l": "maleate + NH4(+) => H2O + maleamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26030", "l": "H2O + N(1)-acetylspermidine + O2 <=> 3-aminopropanal + H2O2 + N-acetylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0090432", "l": "myristoyl-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + myristic acid + CoA = AMP + diphosphate + myristoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56689", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 => (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759158", "l": "SQSTM1 oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787820", "l": "IL34 dimer binds CSF1R (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168886", "l": "Hemopexin binds Hemes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18572", "l": "an aromatic aldehyde + H2O + O2 <=> an aromatic carboxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165055", "l": "Hydrolysis of Ran:GTP to Ran:GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692154", "l": "SOX9 binds the PTGDS gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0016655", "l": "oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule."]}, {"i": "EC:1.6.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983421", "l": "Journey of cargo through Golgi complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67680", "l": "a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57369", "l": "H2O + NADPH => (6R)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11403", "l": "GDP-6-deoxy-alpha-D-altrose + sordaricin <=> 4'-O-demethylsordarin + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28311", "l": "beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-179421", "l": "Degradation of multiubiquitinated Nek2A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16803", "l": "adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein] => 3'-phosphoadenylyl sulfate + L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22843", "l": "D-glutamine + H2O <=> D-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20150", "l": "O2 + quinine + reduced [NADPH--hemoprotein reductase] => 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390835", "l": "DRD1,5 bind DA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727944", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to EEF1A1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27285", "l": "2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23532", "l": "ATP + cholate + CoA = AMP + choloyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.5", "l": "\"3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72433", "l": "(E)-caffeoyl-AMP + diphosphate => (E)-caffeate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0033931", "l": "endogalactosaminidase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-alpha-D-galactosaminidic linkages in poly(D-galactosamine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68615", "l": "Formation of ORC(1-6) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37614", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66057", "l": "indole-3-pyruvate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48955", "l": "14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) <=> 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63604", "l": "[Pyr1]apelin-13 + H2O = [Pyr1]apelin-12 + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2404135", "l": "RBP4 binds atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59556", "l": "H2O + N,N'-diacetylchitobiono-1,5-lactone = H(+) + N,N'-diacetylchitobionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33690", "l": "3'-N-debenzoyltaxol + benzoyl-CoA <=> CoA + H(+) + taxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62541", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabain => dihydroouabain + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12613", "l": "2 glutathione + L-cystine = glutathione disulfide + 2 L-cysteine", "d": []}, {"i": "EC:1.8.4.4", "l": "\"glutathione--cystine transhydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169402", "l": "ISGylation of E2 conjugating enzymes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27861", "l": "2',3'-cyclophospho-GMP + H2O <=> 3'-GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086083", "l": "cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication", "d": ["Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050418", "l": "hydroxylamine reductase activity", "d": ["Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13068", "l": "ATP + H2O <=> ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865482", "l": "KMT2A (MLL) binds RUNX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0015930", "l": "glutamate synthase activity", "d": ["Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38125", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30052", "l": "fluoroacetate + H2O => fluoride + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865605", "l": "BRWD1 binds SMARCA4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36629", "l": "CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine => 2-hydroxytetracosanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187506", "l": "Translocation of p27 to the nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615626", "l": "PMP22 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38888", "l": "H2O + N-hexanoyl-sphinganine => hexanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.80", "l": "\"acetylajmaline esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987039", "l": "JAK1 binds IL20RA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63223", "l": "7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975170", "l": "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54024", "l": "2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 = (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371435", "l": "Constitutive phosphorylation by GSK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030761", "l": "8-hydroxyquercitin 8-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine(1+) = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38891", "l": "H2O + N-hexadecanoylsphing-4-enine = hexadecanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9749253", "l": "Formation of MCM2-7 complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-874087", "l": "SGT1 binds HSP90 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0120296", "l": "peptide dopaminyltransferase activity", "d": ["Catalysis of the reaction: dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4(+)."]}, {"i": "RHEA:66556", "l": "dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28423", "l": "(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200406", "l": "CPT1A,B transfers PALM to CAR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33237", "l": "3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+) => 2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52186", "l": "1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052682", "l": "epi-cedrol synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = epi-cedrol + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.509418971541265", "identifiers": [{"i": "GO:0052689", "l": "carboxylic ester hydrolase activity", "d": ["Catalysis of the hydrolysis of a carboxylic ester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42523", "l": "uridine(2605) in 23S rRNA <=> pseudouridine(2605) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340214", "l": "CYGB binds O2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26019", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O = beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate", "d": []}, {"i": "EC:3.1.3.79", "l": "\"mannosylfructose-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29129", "l": "a menaquinone + H2O + nitrite => a menaquinol + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22283", "l": "O-demethylpuromycin + S-adenosyl-L-methionine <=> H(+) + puromycin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36255", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O", "d": []}, {"i": "EC:1.14.16.5", "l": "\"alkylglycerol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64728", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874078", "l": "PTK2 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.211", "l": "\"rifampicin monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0050187", "l": "phosphoamidase activity", "d": ["Catalysis of the reaction: N-phosphocreatine + H2O = creatine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30040", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 => benzene-1,2,4-triol + CO2 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74712", "l": "Dissociation of IRS-P from insulin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917696", "l": "Cargo Sequestration (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69559", "l": "D-glucose(out) + H(+)(out) <=> D-glucose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432129", "l": "FGR binds and phosphorylates LRP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42665", "l": "alpha-L-arabinopyanose + NADP(+) => H(+) + L-arabinono-1,4-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635845", "l": "GLI proteins bind CDC73 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71320", "l": "chloride(out) + L-cysteine(out) + 2 Na(+)(out) => chloride(in) + L-cysteine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74170", "l": "H2O + N,N-dimethylglycine + oxidized 2[4Fe-4S]-[ferredoxin] <=> formaldehyde + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018620", "l": "phthalate 4,5-dioxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45706", "l": "(E)-sinapaldehyde + H(+) + NADPH => (E)-sinapyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58281", "l": "4 ATP => cyclic tetraadenylate + 4 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48456", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = 2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50258", "l": "25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693478", "l": "HTR1A binds HTR1A agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39372", "l": "3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0043110", "l": "rDNA spacer replication fork barrier binding", "d": ["Binding to replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21976", "l": "[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate", "d": []}, {"i": "EC:1.8.4.10", "l": "\"adenylyl-sulfate reductase (thioredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50489", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73468", "l": "beta-alanyl-dopamine + H2O => beta-alanine + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54208", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21430", "l": "H(+) + pyruvate + sulfite => (2R)-3-sulfolactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1972385", "l": "ADP-Ribosylation of HNP-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103058", "l": "kaempferol 3-glucoside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-L-rhamnose <=> kaempferol-3-glucoside-7-rhamnoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0031071", "l": "cysteine desulfurase activity", "d": ["Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43342", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase] => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987043", "l": "IL22RA1 binds JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71326", "l": "chloride(out) + L-asparagine(out) + 2 Na(+)(out) <=> chloride(in) + L-asparagine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68043", "l": "(R)-lanthionine ketimine + 2 H(+) + NADPH <=> (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64509", "l": "acetyl-CoA + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine => 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + 4 CO2 + 5 CoA + H2O + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018510", "l": "phloroglucinol reductase activity", "d": ["Catalysis of the reaction: dihydrophloroglucinol + NADP+ = H+ + NADPH + phloroglucinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050259", "l": "ribose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: H2O + NADP+ + ribofuranose = D-ribonate + 2 H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32021", "l": "beta-cubebene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67468", "l": "H2O + malonyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168136", "l": "Activated JNKs phosphorylate c-JUN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0050456", "l": "cystine reductase activity", "d": ["Catalysis of the reaction: 2 L-cysteine + NAD+ = L-cystine + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55677", "l": "chorismate + NH4(+) => (2S)-2-amino-4-deoxychorismate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72765", "l": "anthocyanin A11 + CoA => anthocyanin A10 + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10628", "l": "phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)", "d": []}, {"i": "EC:2.7.7.56", "l": "\"tRNA nucleotidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008191", "l": "metalloendopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592278", "l": "Autocatalytic activation of proMMP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64982", "l": "20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140343", "l": "phosphatidylserine transfer activity", "d": ["Removes phosphatidylserine from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186765", "l": "PLC-gamma binds to the active receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865107", "l": "MICAL1 produces NADP+, H2O2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41600", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47287", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797553", "l": "Protein 4.1 binds CASK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712187", "l": "GNAL:GTP (G alpha-olf) binds ADCY3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53894", "l": "a prenal + H2O2 + L-cysteine => an S-prenyl-L-cysteine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70303", "l": "beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55558", "l": "an oxoeicosatetraenoate + H2O => a hydroperoxyeicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75280", "l": "an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy-medium-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195251", "l": "Assembly of the destruction complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362427", "l": "Hh-Np binds GPC5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21545", "l": "(2E,6E)-farnesyl diphosphate + ATP => (2E,6E)-farnesyl triphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16166", "l": "L-tryptophan + O2 => CO2 + H2O + indole-3-acetamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43916", "l": "(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.53", "l": "\"sialate O-acetylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214864", "l": "Phosphorylated CACT and DL/DIF dimer dissociate from the TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875568", "l": "RAPGEF1 activates RAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008976", "l": "polyphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23372", "l": "ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine", "d": []}, {"i": "EC:6.3.2.8", "l": "\"UDP-N-acetylmuramate--L-alanine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69299", "l": "CDT1 binds geminin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36104", "l": "anthranilate + S-adenosyl-L-methionine => O-methyl anthranilate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811427", "l": "COPI vesicle uncoating at the ER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014433", "l": "RHOG GEFs activate RHOG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9715355", "l": "lorlatinib-resistant ALK mutants don't bind lorlatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1013020", "l": "Activation of GIRK/Kir3 Channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.154", "l": "\"sterol 14alpha-demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23660", "l": "4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate", "d": []}, {"i": "EC:3.5.2.7", "l": "\"imidazolonepropionase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202164", "l": "Translocation of PDK1 to Plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004073", "l": "aspartate-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP+ + phosphate = 4-phospho-L-aspartate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0000293", "l": "ferric-chelate reductase activity", "d": ["Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe3+-siderophore + electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28440", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + holo-[ACP] => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.194933448780617", "identifiers": [{"i": "GO:0016831", "l": "carboxy-lyase activity", "d": ["Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33312", "l": "2 A + hydroxylamine + NH4(+) => 2 AH2 + H(+) + H2O + N2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58771", "l": "1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32344", "l": "(+)-thujan-3-ol + NAD(+) => (+)-thujan-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5159250", "l": "ATF7IP binds SETDB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66947", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14764", "l": "H(+) + hexadecanoyl-CoA + L-serine <=> 3-oxosphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12075", "l": "an (S)-2-haloacid + H2O <=> a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168848", "l": "tBID binds to inactive BAK protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14341", "l": "2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO2", "d": []}, {"i": "EC:2.2.1.5", "l": "\"2-hydroxy-3-oxoadipate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12073", "l": "an (S)-2-haloacid + H2O => a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70516", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose => 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788867", "l": "FN3K phosphorylates ketosamines (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51171", "l": "(R)-adrenaline + H2O + O2 <=> (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.100", "l": "\"sedolisin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050559", "l": "copalyl diphosphate synthase activity", "d": ["Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-copalyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132094", "l": "C8 binds to C5b:C6:C7 complement complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42492", "l": "3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 = 3'-N-debenzoyltaxol + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113402", "l": "Formation of DSIF:NELF:early elongation complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247843", "l": "secretion of WNT ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814096", "l": "ARL1:GTP binds SCOC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32776", "l": "(2-aminoethyl)phosphonate(out) + ATP + H2O => (2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110244", "l": "Excision of FapyG by OGG1 glycosylase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373729", "l": "Neurofascin binds Ankyrin-G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62260", "l": "2 hydrogencarbonate(out) + Mn(2+)(out) = 2 hydrogencarbonate(in) + Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61047", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217147", "l": "Phosphorylation of c-Abl and Arg by ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65815", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2 <=> A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418925", "l": "ADORA2A,B bind Ade-Rib (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35613", "l": "2 H(+) + menadione + 2 superoxide => menadiol + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202459", "l": "Phosphorylation of Bcl10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32876", "l": "a 1-acyl-sn-glycerol + H2O => a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9017491", "l": "RHOJ GEFs activate RHOJ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63766", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51489", "l": "archaetidylserine + H(+) => archaetidylethanolamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1449687", "l": "Corticosteroids bind to CBG in blood (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40578", "l": "glutaryl-CoA + H2O <=> CoA + glutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75274", "l": "S-adenosyl-L-methionine + serotonin <=> 5-methoxytryptamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874083", "l": "p-Y397-PTK2 binds SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53147", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18964", "l": "D-allose + L-lysyl-[protein] <=> H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50766", "l": "4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine => 4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32298", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH <=> 2 diphosphate + NADP(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56662", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9681375", "l": "KIT binds ripretinib (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39282", "l": "ATP + dodecanoate(out) + H2O <=> ADP + dodecanoate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38689", "l": "(4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate => (4R)-hydroxysphinganine(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33428", "l": "(S)-malyl alpha-D-glucosaminide + L-cysteine => bacillithiol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33441", "l": "glyoxylate + H(+) + H2O2 => glyoxal + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32872", "l": "a 2-acylglycerol + H2O => a carboxylate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956659", "l": "ABL1 phosphorylates YAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008807", "l": "carboxyvinyl-carboxyphosphonate phosphorylmutase activity", "d": ["Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20939", "l": "2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483174", "l": "PE is methylated to PC by PEMT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193702", "l": "Part of the ICD migrates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9796626", "l": "MIB2 ubiquitinates CFLAR  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35348", "l": "3-hydroxyoctadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22602", "l": "acetate + H(+) + N-acetylneuraminate => H2O + N-acetyl-9-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102164", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone synthase activity", "d": ["Catalysis of the reaction: 2-heptyl-4-quinolone + NADH + O2 + H+ <=> 2-heptyl-3-hydroxy-4-quinolone + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15911", "l": "aminoacetaldehyde + CO2 + H(+) + succinate + sulfite => 2-oxoglutarate + O2 + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36981", "l": "3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA => (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72185", "l": "mRNA polyadenylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21154", "l": "cis-4-hydroxy-D-proline => trans-4-hydroxy-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062180", "l": "25-hydroxycholecalciferol-23-hydroxylase activity", "d": ["Catalysis of the reaction: calcidiol + 2 H+ + O2 + 2 reduced [adrenodoxin] = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]."]}, {"i": "RHEA:46616", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46071", "l": "(3E)-nonenoyl-CoA <=> (2E)-nonenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24842", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.21", "l": "\"rhizopuspepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102822", "l": "quercetin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine = H+ + isorhamnetin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1980044", "l": "NOTCH1 binds JAG2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875661", "l": "GGA3 associates with activated MET receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9823816", "l": "OPTN binds CASP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939082", "l": "RUNX1 binds the CR1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69902", "l": "2 Na(+)(out) + thymidine(out) <=> 2 Na(+)(in) + thymidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29094", "l": "a ubiquinone + 5 H(+)(in) + NADH <=> a ubiquinol + 4 H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10766", "l": "(4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate => (2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956659", "l": "ABL1 phosphorylates YAP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10979", "l": "H(+) + NADH + O2 + quinolin-2-ol <=> 5,6-dihydroquinoline-2,5,6-triol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55057", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61023", "l": "acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA <=> 5'-deoxyadenosine + 5-(carboxymethyl)uridine(34) in tRNA + CoA + 2 H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170004", "l": "lipoate transmembrane transporter activity", "d": ["Enables the transfer of lipoate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15180", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70052", "l": "2-oxoadipate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56289", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24540", "l": "A + D-glucose = AH2 + D-glucono-1,5-lactone", "d": []}, {"i": "EC:1.1.99.35", "l": "\"soluble quinoprotein glucose dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23678", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate => ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57746", "l": "[protein]-dithiol + phylloquinone => [protein]-disulfide + phylloquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696358", "l": "TREM,CD300 binds lipids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20555", "l": "(S)-methylmalonyl-CoA => (R)-methylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052678", "l": "levopimaradiene synthase activity", "d": ["Catalysis of the reaction: (+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918229", "l": "Phosphorylation and release of IRF3/IRF7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31235", "l": "(4S)-4-hydroxy-L-glutamate + 2-oxoglutarate = (4R)-4-hydroxy-2-oxoglutarate + L-glutamate", "d": []}, {"i": "EC:2.6.1.23", "l": "\"4-hydroxyglutamate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11469", "l": "(S)-3-methyl-2-oxopentanoate + L-valine => 3-methyl-2-oxobutanoate + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0050521", "l": "alpha-glucan, water dikinase activity", "d": ["Catalysis of the reaction: ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849908", "l": "SALM4 binds flotillin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549322", "l": "OCT1 transports organic cations out of hepatic cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69167", "l": "H2O + N-(4-aminobutyl)-3-aminopropanal + NAD(+) <=> 2 H(+) + N-(2-carboxyethyl)putrescine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22711", "l": "H2O + S-acylglutathione <=> a carboxylate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613644", "l": "SOX10-dependent POU3F1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043759", "l": "methylbutanoate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + 2-methylbutanoate + CoA = AMP + diphosphate + 2-methylbutanoyl-CoA."]}, {"i": "RHEA:46180", "l": "2-methylbutanoate + ATP + CoA = 2-methylbutanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-532549", "l": "MPI isomerises Fru6P to Man6P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69538", "l": "ADP + D-tagatofuranose 1,6-bisphosphate + H(+) => alpha-D-tagatopyranose 1-phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866277", "l": "AP-2 directly binds some endocytic cargo (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52023", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 <=> A + H2O + resolvin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047268", "l": "galactinol-raffinose galactosyltransferase activity", "d": ["Catalysis of the reaction: raffinose + 1-alpha-D-galactosyl-myo-inositol = stachyose + myo-inositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.120", "l": "\"oviductin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26403", "l": "(2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone => all-trans-10'-apo-beta-carotenal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39787", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74992", "l": "Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52867", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692437", "l": "ANG binds F-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70105", "l": "penilactone B => H(+) + o-quinone methide + penilactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45901", "l": "a (3Z)-enoyl-CoA => a 4-saturated (2E)-enoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198314", "l": "DAG stimulates protein kinase C-delta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49470", "l": "a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75667", "l": "(11Z,14Z,17Z)-eicosatrienoate + O2 = 12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54049", "l": "(2E,6E)-farnesyl diphosphate + H2O => 4-epi-cubebol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953111", "l": "E2F6 binds TFDP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57391", "l": "(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981355", "l": "RASA1 binds RAS:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49596", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose = H(+) + N-acyl-D-galactosylsphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610723", "l": "GLI proteins bind SUFU (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-481010", "l": "Surface deployment of platelet dense granule membrane components (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71340", "l": "chloride(out) + L-tyrosine(out) + 2 Na(+)(out) => chloride(in) + L-tyrosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004745", "l": "NAD-retinol dehydrogenase activity", "d": ["Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39699", "l": "(R)-3-hydroxy-(13Z)-eicosenoyl-CoA = (2E,13Z)-eicosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014454", "l": "RHOG translocates to the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53668", "l": "(2E,6E)-farnesyl diphosphate = (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate", "d": []}, {"i": "EC:4.2.3.165", "l": "\"(1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-139941", "l": "Binding of IP3 to IP3 receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902485", "l": "L-cysteine binding", "d": ["Binding to L-cysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33939", "l": "H(+) + L-arginine + NADH + O2 = H2O + N(omega)-hydroxy-L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665871", "l": "ADRM1 binds 26S proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30789", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47021", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O => [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59249", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA => (E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67987", "l": "N-acetyl-L-leucine <=> N-acetyl-D-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36242", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-alkyl-2-acyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70747", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731924", "l": "EDNRA binds EDNs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73434", "l": "(2S)-sakuranetin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-7-methylcarthamidin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170003", "l": "heme B transmembrane transporter activity", "d": ["Enables the transfer of heme B from one side of a membrane to the other."]}, {"i": "RHEA:75443", "l": "heme b(in) = heme b(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9620456", "l": "sGC stimulators bind sGC:NO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876210", "l": "InlB promotes MET dimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40627", "l": "H2O + trihexadecanoylglycerol = 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72938", "l": "(S)-lactate(out) + 2 Na(+)(out) <=> (S)-lactate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69125", "l": "glyoxylate + L-tryptophan => glycine + indole-3-pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66383", "l": "ATP + glutathione(in) + glycodeoxycholate(in) + H2O <=> ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382057", "l": "Release of novel PDGFs as latent factors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140769", "l": "factor VII -> factor VIIa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616105", "l": "EGR1 binds CDK5R1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729741", "l": "SARS-CoV-2 3CLpro dimer cleaves NLRP12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48303", "l": "H2O + prostaglandin F2alpha 1-glyceryl ester <=> glycerol + H(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34461", "l": "diphosphate + sclareol => 8-hydroxycopalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46617", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374909", "l": "Metabolism of Noradrenaline (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48810", "l": "(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43145", "l": "adenosine(22) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29016", "l": "phosphate(out) + sn-glycerol 3-phosphate(in) => phosphate(in) + sn-glycerol 3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75632", "l": "H2O + plasmodiophorol B => plasmodiophorol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909729", "l": "Activation of JAK kinases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176517", "l": "SULTs transfer (SO4)2- group to PREG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61705", "l": "ATP + holo-[peptidyl-carrier protein] + L-serine => AMP + diphosphate + L-seryl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9681616", "l": "AP2 binds chlorpromazine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392870", "l": "Gs activation by prostacyclin receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30479", "l": "L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36723", "l": "2-phenylethylamine + A + H2O = 2-phenylacetaldehyde + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54820", "l": "a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247922", "l": "GGCT transforms gGluCys to OPRO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9794523", "l": "SLC22A1 transports Cipro into renal cell (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43779", "l": "an N-(acyl)-sphingosylphosphocholine(in) <=> an N-(acyl)-sphingosylphosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19361", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.10", "l": "\"(2E,6E)-farnesyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9671145", "l": "DKC1 binds SHQ1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63497", "l": "4-nitrobenzaldehyde + H(+) + NADPH => 4-nitrobenzyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42376", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033845", "l": "hydroxymethylfurfural reductase (NADPH) activity", "d": ["Catalysis of the reaction: 5-hydroxymethylfurfural + NADPH + H+ = 2,5-bis-hydroxymethylfuran + NADP+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034524", "l": "2-hydroxyisophthalate decarboxylase activity", "d": ["Catalysis of the reaction: 2-hydroxyisophthalic acid = salicylate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134962", "l": "DHX36 binds DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18875", "l": "chloride + H(+) + NH4(+) + pyruvate => 3-chloro-D-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22160", "l": "4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside = a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA", "d": []}, {"i": "EC:2.3.1.173", "l": "\"flavonol-3-O-triglucoside O-coumaroyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49788", "l": "chenodeoxycholoyl-CoA + glycine = CoA + glycochenodeoxycholate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30819", "l": "allantoin + H2O = allantoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20784", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginine = ADP-D-ribose + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44385", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA => 1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36433", "l": "2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase => a purine 2'-deoxy-D-ribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685011", "l": "ATR activation at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008866", "l": "fructuronate reductase activity", "d": ["Catalysis of the reaction: D-mannonate + NAD+ = D-fructuronate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0005149", "l": "interleukin-1 receptor binding", "d": ["Binding to an interleukin-1 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69853", "l": "a uridine in mRNA + H(+) + NADH => a 5,6-dihydrouridine in mRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46325", "l": "3-oxochol-4-en-22-oyl-CoA + A => 3-oxochola-4,17-dien-22-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38366", "l": "1-octadecanoylglycerol + H2O <=> glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612483", "l": "EGR1,2,3 bind the NAB2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34530", "l": "L-phenylalanine <=> (S)-3-amino-3-phenylpropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24727", "l": "N-demethylindolmycin + S-adenosyl-L-methionine => H(+) + indolmycin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57275", "l": "a 2'-deoxyguanosine in DNA + methylglyoxal <=> an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250220", "l": "Homodimerization of ERBB4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63711", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60097", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => 3-dehydro-4alpha-methylzymosterol + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59267", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36674", "l": "(17Z)-hexacosenoyl-CoA + sphinganine <=> CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20470", "l": "H2O + IMP => D-ribose 5-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63036", "l": "H2O + octadecanamide = NH4(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.3.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53974", "l": "(8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37708", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31504", "l": "beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate => 4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32574", "l": "(E)-2-methylgeranyl diphosphate + H2O <=> 2-methylisoborneol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21793", "l": "NADP(+) + propan-2-ol => acetone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390835", "l": "DRD1,5 bind DA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59269", "l": "A + H2O + N(6)-methyl-L-lysyl-[protein] => AH2 + formaldehyde + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69098", "l": "H2O + kynurenate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43826", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12561", "l": "hydroquinone + UDP-alpha-D-glucose => H(+) + hydroquinone O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15202", "l": "6-hydroxymellein + S-adenosyl-L-methionine => 6-methoxymellein + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29131", "l": "menaquinol-8 + nitrate = H2O + menaquinone-8 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36416", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine => diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68914", "l": "DNA polymerase alpha:primase binds at the origin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67152", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein] = L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187382", "l": "Degradation of ubiquitinated SMAD3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689111", "l": "PARK2 autoubiquitinates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42531", "l": "uridine(955/2504/2580) in 23S rRNA <=> pseudouridine(955/2504/2580) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682769", "l": "LGI2 binds ADAM22,23 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73795", "l": "dimethylallyl diphosphate + neoechinulin A = diphosphate + isoechinulin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940561", "l": "MMP7 cleaves OPTC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18948", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55032", "l": "an N-methylornithine lipid + S-adenosyl-L-methionine = an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162657", "l": "Inactivation of Myt1 kinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036143", "l": "kringle domain binding", "d": ["Binding to a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54446", "l": "a (2R,3R)-dihydroflavonol + H(+) + NADPH => a (2R,3S,4S)-leucoanthocyanidin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71735", "l": "formyl-CoA + succinate = formate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56667", "l": "7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45450", "l": "dodecanoate + sphinganine => H2O + N-(dodecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11957", "l": "cholesteryl 3-beta-D-glucoside + H2O => cholesterol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667563", "l": "AVPR2 bind desmopressin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34185", "l": "alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+) => alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49882", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33807", "l": "(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449855", "l": "IL10 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28090", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}, {"i": "EC:2.7.8.33", "l": "\"UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237119", "l": "Acireductone is oxidized to MOB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042972", "l": "licheninase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D-glucans containing (1->3) and (1->4) bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46124", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.26", "l": "\"24-hydroxycholesterol 7alpha-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59525", "l": "9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] => 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0015489", "l": "putrescine transmembrane transporter activity", "d": ["Enables the transfer of putrescine from one side of a membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24642", "l": "D-glucose + ergosterol => ergosteryl 3-beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784189", "l": "JAKs bind LIFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928607", "l": "p-EPHs bind VAV2,3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62843", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10568", "l": "luteolin + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-beta-D-glucuronide + UDP", "d": []}, {"i": "EC:2.4.1.189", "l": "\"luteolin 7-O-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30938", "l": "H2O + nicotinate beta-D-ribonucleotide <=> beta-D-ribosylnicotinate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9733973", "l": "Bile salts bind FABP6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9656947", "l": "OGG1beta translocates to mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50059", "l": "ATP + glycocholate(in) + H2O <=> ADP + glycocholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61858", "l": "betaenone C + 3 H2O + 3 NADP(+) => dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050304", "l": "nitrous-oxide reductase activity", "d": ["Catalysis of the reaction: H2O + 2 cytochrome c + nitrogen = 2 reduced cytochrome c + nitrous oxide."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0016652", "l": "oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP."]}, {"i": "EC:1.6.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59734", "l": "AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein] => biotinyl-5'-AMP + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20771", "l": "3-phosphonopyruvate + H(+) <=> CO2 + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16175", "l": "(S)-norcoclaurine + H2O => (4-hydroxyphenyl)acetaldehyde + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706330", "l": "Active FLT3 binds to SOCS6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74717", "l": "3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine => 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68868", "l": "ATP + benzoate + H(+) + NADPH = AMP + benzaldehyde + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12345", "l": "(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) => H(+) + L-glutamyl-tRNA(Glu) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678854", "l": "S1PR1 binds S1PR1 agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35322", "l": "H(+) + malonyl-CoA + octadecanoyl-CoA <=> 3-oxoeicosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187332", "l": "Cytosolic CMs translocate to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36213", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62395", "l": "levoglucosan + NAD(+) <=> 3-dehydrolevoglucosan + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66687", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] <=> L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53563", "l": "9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149519", "l": "MMACHC decyanates CNCbl (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964939", "l": "Phosphorylation of shikimate (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18227", "l": "6-aminohexanoate + [N-(6-aminohexanoyl)](n-1) => [N-(6-aminohexanoyl)](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10380", "l": "diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate", "d": []}, {"i": "EC:2.4.2.10", "l": "\"orotate phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69594", "l": "cytidine + IMP => CMP + inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2660816", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15609", "l": "ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)", "d": []}, {"i": "EC:2.7.6.1", "l": "\"ribose-phosphate diphosphokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-481010", "l": "Surface deployment of platelet dense granule membrane components (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48583", "l": "[pyruvate, water dikinase]-phosphate + H(+) + phosphate <=> [pyruvate, water dikinase] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13035", "l": "keto-D-tagatose 6-phosphate => aldehydo-D-galactose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21352", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)", "d": []}, {"i": "EC:1.13.11.25", "l": "\"3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613497", "l": "Unwinding DNA for the nascent transcript (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31776", "l": "all-trans-retinyl hexadecanoate + H2O => 11-cis-retinol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16976", "l": "2-hydroxypyridine + AH2 + O2 <=> 2,5-dihydroxypyridine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247847", "l": "WLS is endocytosed to the early endosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804527", "l": "INTL1 binds bacterial glycans (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189439", "l": "ALAD condenses 2 dALAs to form PBG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16600", "l": "ATP + NH4(+) + UTP <=> ADP + CTP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693125", "l": "RHOF binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109639", "l": "Formation of the closed pre-initiation complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.14", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031458", "l": "ABC-type betaine transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + a betaine(out) = ADP + phosphate + a betaine(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40272", "l": "O2 + tetradecanedioyl-CoA => (2E)-tetradecenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13999", "l": "2-methylpropanoyl-CoA + CO2 + NADH => 3-methyl-2-oxobutanoate + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61794", "l": "diphosphate + L-tryptophyl-5'-AMP => ATP + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432946", "l": "PARVB/Affixin interacts with alpha PIX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183067", "l": "Localization of CBL:GRB2 to the membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27886", "l": "2',3'-cyclophospho-AMP + H2O = 3'-AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.3.5", "l": "\"prenylcysteine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36999", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20005", "l": "an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate", "d": []}, {"i": "EC:3.2.1.139", "l": "\"alpha-glucuronidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15934", "l": "(S)-propane-1,2-diol + NAD(+) => (S)-lactaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10909", "l": "3'-phosphoadenylyl sulfate + glycolithocholate => adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-517705", "l": "p-S318,221-HuR binds mRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30292", "l": "(9Z,12Z)-octadecadienoate + O2 => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30640", "l": "(R)-glycerate + GDP-alpha-D-mannose => (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55882", "l": "[aequorin] => apo-[aequorin]--coelenterazine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10649", "l": "2-hydroxycyclohexan-1-one + H(+) + NADPH + O2 => 6-hydroxyhexan-6-olide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2002401", "l": "Association of procollagen type XVIII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443926", "l": "Thrombopoietin binds the thrombopoietin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70218", "l": "cortisol + H(+) + NADPH <=> 20beta-dihydrocortisol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016594", "l": "glycine binding", "d": ["Binding to glycine, aminoethanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69005", "l": "Cdc6 protein is phosphorylated by CDK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23621", "l": "ATP + N(2)-(2-carboxyethyl)-L-arginine => AMP + deoxyamidinoproclavaminate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20155", "l": "ADP + beta-L-arabinose 1-phosphate + H(+) => ATP + L-arabinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40449", "l": "(2S)-pristanoyl-CoA => (2R)-pristanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451450", "l": "Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16310", "l": "H2O + taurochenodeoxycholate => chenodeoxycholate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39668", "l": "a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => a ketone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31408", "l": "all-trans-4,4'-diaponeurosporene + FAD + H(+) => all-trans-4,4'-diapolycopene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210289", "l": "Recruitment of SYK to p-DAP12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429955", "l": "CCR4-NOT complex deadenylates mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047722", "l": "indolelactate dehydrogenase (NADH) activity", "d": ["Catalysis of the reaction: 3-(indol-3-yl)lactate + NAD+ = 3-(indol-3-yl)pyruvate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60441", "l": "H2O + methyl acetate => acetate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400282", "l": "CRY proteins are ubiquitinylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.27", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001155", "l": "TFIIIA-class transcription factor binding", "d": ["Binding to an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at RNA polymerase III promoters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31778", "l": "all-trans-retinyl hexadecanoate + H2O <=> 11-cis-retinol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3234084", "l": "SUMOylation of TFAP2B with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004476", "l": "mannose-6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39567", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26542", "l": "(R)-piperazine-2-carboxamide + H2O = (R)-piperazine-2-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46620", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69084", "l": "acrolein + H2O + NAD(+) = acrylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616110", "l": "EGR1-dependent CDK5R1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760128", "l": "AcK-NFE2L2-dependent GSTA1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33653", "l": "(9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate => (9Z,12Z)-octadecadienoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160003", "l": "mono-ADP-D-ribose modification-dependent protein binding", "d": ["Binding to a protein upon mono-ADP-ribosylation of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11981", "l": "2 gamma-L-glutamyl-L-cysteine + NADP(+) => bis-gamma-glutamylcystine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202174", "l": "Activation of ZAP-70 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38345", "l": "(20S)-ginsenoside Rg3 + D-glucose => (20S)-ginsenoside Rd + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15304", "l": "D-apiitol + NAD(+) <=> aldehydo-D-apiose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21148", "l": "indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.156", "l": "\"indolylacetyl-myo-inositol galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71524", "l": "adenine(out) => adenine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694409", "l": "Nucleotide exchange on RAB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73754", "l": "(R)-adrenaline(in) + 2 H(+)(out) <=> (R)-adrenaline(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0072328", "l": "alkene binding", "d": ["Binding to an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10596", "l": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40703", "l": "(9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627104", "l": "XIAP binds CASP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24894", "l": "5-hydroxyxanthotoxin + S-adenosyl-L-methionine = isopimpinellin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36462", "l": "glycyl-L-proline + H2O <=> glycine + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59592", "l": "ATP + beta-alanine + L-arginine = ADP + beta-alanyl-L-arginine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32341", "l": "(+)-thujan-3-one + H(+) + NADPH => (+)-thujan-3-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65278", "l": "2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23299", "l": "aceneuramate <=> N-acetyl-D-mannosamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23890", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate => [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25721", "l": "(E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-trihomomethionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.60", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369115", "l": "SHP2 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62138", "l": "dGDP + GDP => dGMP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72950", "l": "acetate(out) + 2 Na(+)(out) <=> acetate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114552", "l": "Thrombin-activated PARs activate G12/13 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44473", "l": "1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036070", "l": "Defective GUSB does not hydrolyse CS/HS precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694527", "l": "Loss of SAR1B GTPase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047695", "l": "benzoin aldolase activity", "d": ["Catalysis of the reaction: benzoin = 2 benzaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75097", "l": "2 chloride(out) + oxalate(in) => 2 chloride(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004690", "l": "cyclic nucleotide-dependent protein kinase activity", "d": ["cNMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050589", "l": "leucocyanidin oxygenase activity", "d": ["Catalysis of the reaction: leucocyanidin + 2-oxoglutarate + O2 = cis- or trans-dihydroquercetin + succinate + CO2 + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57217", "l": "dGTP + glyoxal => N(2)-(1-hydroxy-2-oxoethyl)-dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70415", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + H2O = (3,5-dihydroxyphenyl)acetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64474", "l": "(2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine => (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45994", "l": "(2E)-decenoyl-CoA + H2O => (3R)-3-hydroxydecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66951", "l": "acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34140", "l": "Delta(9)-tetrahydrocannabinolate + H(+) => CO2 + Delta(9)-tetrahydrocannabinol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008797", "l": "aspartate ammonia-lyase activity", "d": ["Catalysis of the reaction: L-aspartate = fumarate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389919", "l": "Grb2 binds pBTLA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928591", "l": "EPH:EFN tetramers oligomerise (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33040", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin => 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75020", "l": "1,2,3-tri-(10Z)-heptadecenoylglycerol + 9-hydroxy-octadecanoate => 9-(10Z-heptadecenoyloxy)-octadecanoate + di-(10Z)-heptadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372819", "l": "PCK2 phosphorylates OA to yield PEP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420274", "l": "GIP receptor binds gastric inhibitory peptide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111962", "l": "PDE4A,C,D hydrolyse cAMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37015", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093331", "l": "Ras:GTP binds p120-RasGAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-606289", "l": "New CENPA-containing nucleosomes are deposited at the centromere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15696", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 <=> (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16269", "l": "aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) = 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH", "d": []}, {"i": "EC:1.7.1.6", "l": "\"azobenzene reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53425", "l": "a fatty acyl-CoA + a sphingoid base => an N-acyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72818", "l": "L-lysine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) <=> L-lysine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42626", "l": "(Z)-3-aminoacrylate + CO2 + NH4(+) => (Z)-3-ureidoacrylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61761", "l": "rebaudioside B + UDP-alpha-D-glucose => rebaudioside A + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794475", "l": "Cipro:ALB dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806613", "l": "Keratin tetramers bind to form unit length filaments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191654", "l": "c-src associates with Cx43 in gap junctions (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33563", "l": "(4R)-hydroxysphinganine + ATP = (4R)-hydroxysphinganine 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23175", "l": "ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] <=> ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855648", "l": "SALM3 binds LAR-RPTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15418", "l": "L-arogenate + NADP(+) => CO2 + L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50812", "l": "androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24803", "l": "(S)-3-methyl-2-oxopentanoate + L-glutamate => 2-oxoglutarate + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60403", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54159", "l": "2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 <=> [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54231", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine <=> 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37156", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805740", "l": "SETD8 methylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797100", "l": "CCNK binds CDK13 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390674", "l": "ADRB1 bind ADR,NAd (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22127", "l": "17-O-acetylajmaline + H2O <=> acetate + ajmaline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46810", "l": "[trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine => [trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264834", "l": "Endocytosis and degradation of apoA-I (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730841", "l": "Phosphorylation and activation of VAV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59185", "l": "2,4-diacetylphloroglucinol + H2O => 2-acetylphloroglucinol + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875374", "l": "MET binds LRIG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424485", "l": "Release of p-PLCG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17206", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate => adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27509", "l": "cocaine + H2O <=> benzoate + ecgonine methyl ester + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15035", "l": "H2O2 + pyridoxal => O2 + pyridoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45132", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69116", "l": "Formation of Okazaki fragments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446322", "l": "PARVA associates with Paxillin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47134", "l": "11-cis-retinoate + 2 H(+) + NADH => 11-cis-retinal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27793", "l": "2-all-trans-octaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374699", "l": "UNC5A binds NRAGE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44969", "l": "(2E)-tetradecenoyl-CoA + H(+) + NADPH => NADP(+) + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44345", "l": "ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide A + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12733", "l": "CO2 + diphosphate + nicotinate beta-D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate", "d": []}, {"i": "EC:2.4.2.19", "l": "\"nicotinate-nucleotide diphosphorylase (carboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16014", "l": "ATP + glycine + tRNA(Gly) => AMP + diphosphate + glycyl-tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166869", "l": "TRAF6 binds MEKK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18616", "l": "4-methoxybenzoate + AH2 + O2 <=> 4-hydroxybenzoate + A + formaldehyde + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37629", "l": "1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114683", "l": "Phosphorylation of Platelet Sec-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47122", "l": "H2O + N-docosanoylglycine => docosanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40672", "l": "2-iminopropanoate + H2O => NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17911", "l": "acetaldehyde + formate => (S)-lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13970", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + GTP => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + diphosphate + GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004612", "l": "phosphoenolpyruvate carboxykinase (ATP) activity", "d": ["Catalysis of the reaction: ATP + oxaloacetate = ADP + CO2 + H+ + phosphoenolpyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29906", "l": "ATP + D-ribose(out) + H2O <=> ADP + D-ribose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58575", "l": "O-acetyl-15alpha-stemmadenine + O2 <=> H2O2 + precondylocarpine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63328", "l": "2-(9Z-octadecenoyl)-glycerol + ATP = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0003994", "l": "aconitate hydratase activity", "d": ["Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018814", "l": "RHOT1 hydrolyzes GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70419", "l": "3,4-dihydroxyphenylacetyl-CoA + H2O = 3,4-dihydroxyphenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42414", "l": "ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate => (2R)-2,3-bisphosphoglycerate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10438", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O => 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004505", "l": "phenylalanine 4-monooxygenase activity", "d": ["Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65525", "l": "9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase] => 9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25779", "l": "scyllo-inosose <=> scyllo-inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28220", "l": "H2O + hypochlorous acid => chloride + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11406", "l": "UDP-alpha-D-galacturonate => UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70340", "l": "alpha-D-Gal-(1->6)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O => beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433936", "l": "Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53123", "l": "(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+) <=> 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65435", "l": "a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate <=> a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70592", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19933", "l": "alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate", "d": []}, {"i": "EC:3.1.3.10", "l": "\"glucose-1-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45158", "l": "3-oxopropanoate + CoA + H(+) => 3-oxopropanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54620", "l": "2-oxoglutarate + eicosanoyl-CoA + O2 = 2-hydroxyeicosanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56465", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O => 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448948", "l": "Phosphorylation of E proteins by p38 MAPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874685", "l": "CBL binds MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47240", "l": "H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9035227", "l": "TXN2 binds CysS248-MPST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66806", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate => ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043715", "l": "2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity", "d": ["Catalysis of the reaction: 2,3-diketo-5-methylthiopentyl-1-phosphate = H+ + 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate. 2,3-diketo-5-methylthiopentyl-1-phosphate is also known as DK-MTP-1-P, and 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate as HK-MTPenyl-1-P."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857555", "l": "EGFR phosphorylates GPNMB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209973", "l": "Tyrosine is diiodinated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21478", "l": "[(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP => [(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31846", "l": "2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA <=> 2-oxepin-2(3H)-ylideneacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30444", "l": "2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc => 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17216", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> UDP-N-acetyl-alpha-D-mannosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42993", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (R)-nephthenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634834", "l": "ACHEIs bind ACHE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30015", "l": "alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose = alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683669", "l": "E protein gets N-glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15564", "l": "S-adenosyl-L-methionine + sterigmatocystin <=> 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082391", "l": "Trimerization of HSF1 in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54478", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+) => 1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167415", "l": "G-protein alpha subunit is inactivated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72292", "l": "2,3-dimethylsuccinate(out) + 3 Na(+)(out) => 2,3-dimethylsuccinate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1237160", "l": "MTA is cleaved and phosphorylated (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53464", "l": "1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34000", "l": "zymosterol => 5alpha-cholesta-7,24-dien-3beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46136", "l": "aminopyrrolnitrin + H(+) + NADPH + 2 O2 = 2 H2O + NADP(+) + pyrrolnitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71287", "l": "chloride(out) + L-arginine(out) + 2 Na(+)(out) = chloride(in) + L-arginine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5591052", "l": "PROCR binds Protein C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507873", "l": "Aquaporins passively transport urea out of cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57900", "l": "2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 = adenosine in U6 snRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011543", "l": "DCA binds PDK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54198", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047973", "l": "guanidinoacetate kinase activity", "d": ["Catalysis of the reaction: ATP + guanidinoacetate = ADP + 2 H+ + phosphoguanidinoacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68401", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + gamma-gurjunene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41212", "l": "(indol-3-yl)acetate + H(+) + NADH + O2 => 2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16450", "l": "acetyl-CoA + kanamycin B => CoA + H(+) + N(6')-acetylkanamycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55687", "l": "chorismate + NH4(+) <=> 4-amino-4-deoxychorismate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63665", "l": "(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH => H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0005199", "l": "structural constituent of cell wall", "d": ["The action of a molecule that contributes to the structural integrity of a cell wall."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050408", "l": "[pyruvate kinase]-phosphatase activity", "d": ["Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29509", "l": "(-)-alpha-gurjunene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.47", "l": "\"horrilysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375302", "l": "Kinetochore capture of astral microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.78", "l": "\"phylloquinone omega-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70157", "l": "28-norcastasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937820", "l": "SRC,YES1 bind YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63096", "l": "ilicicolin A epoxide = ilicicolin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169719", "l": "Secreted CD14 binds LPS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37968", "l": "galactitol + NADP(+) => D-galactose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.32", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60639", "l": "N-(dodecanoyl)-sphing-4-enine-1-phosphocholine <=> choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604738", "l": "Active FLT3 dimer binds GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186771", "l": "RNF111 binds SMAD7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37767", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10612", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}, {"i": "EC:2.4.2.38", "l": "\"glycoprotein 2-beta-D-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10971", "l": "a carboxylate + CoA + GTP <=> an acyl-CoA + GDP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20633", "l": "a (3R)-hydroxyacyl-[ACP] + L-ornithine = a lyso-ornithine lipid + H(+) + holo-[ACP]", "d": []}, {"i": "EC:2.3.2.30", "l": "\"L-ornithine N(alpha)-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028583", "l": "Phosphorylation of YAP by LATS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610735", "l": "NUMB binds ITCH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55234", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 Fe(III)-[cytochrome b561] + H2O => 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45209", "l": "coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein] => Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26134", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+) => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48659", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205262", "l": "Direct recruitment of PI3K to p-KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34035", "l": "O2 + paromamine = 6'-oxoparomamine + H2O2", "d": []}, {"i": "EC:1.1.3.43", "l": "\"paromamine 6'-oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59610", "l": "beta-alanine + L-lysine => beta-alanyl-L-lysine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35094", "l": "anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine <=> 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2160931", "l": "Disassembly of tight junctions (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49755", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate <=> CO2 + 2 H2O + NAD(+) + proviolacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5159250", "l": "ATF7IP binds SETDB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016985", "l": "mannan endo-1,4-beta-mannosidase activity", "d": ["Catalysis of the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54280", "l": "2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912407", "l": "NOTCH2 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53753", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627072", "l": "RHOQ binds GOPC:CFTR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57859", "l": "(E)-feruloyl-CoA + 2-oxoglutarate + O2 <=> (E)-6-hydroxyferuloyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74664", "l": "acetylcholine(in) => acetylcholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419334", "l": "Melatonin receptors can bind melatonin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867288", "l": "OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4093342", "l": "SDC2 multimerises (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173723", "l": "C8 binds C5b:C6:C7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937177", "l": "AHR:TCDD binds ARNT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696822", "l": "AKR1B15 reduces EST17b to E1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48832", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605060", "l": "Expression of SCD regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17897", "l": "A + ethylbenzene + H2O = (S)-1-phenylethanol + AH2", "d": []}, {"i": "EC:1.17.99.2", "l": "\"ethylbenzene hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46390", "l": "(24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5615668", "l": "AKR1C3 reduces atRAL to atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47841", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine => (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16167", "l": "CO2 + H2O + indole-3-acetamide => L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59895", "l": "L-2-amino-4-chloropent-4-enoate <=> chloride + H(+) + L-propargylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54953", "l": "ATP + CoA + nonanoate => AMP + diphosphate + nonanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44161", "l": "1D-myo-inositol 6-phosphate + H2O => myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59476", "l": "2 AH2 + 2 ATP + benzoate + L-phenylalanine = 2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72337", "l": "3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + syringate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045015", "l": "HDEL sequence binding", "d": ["Binding to a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944220", "l": "Association of procollagen type XXIII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29824", "l": "chloride(in) => chloride(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55758", "l": "a 2-hydroxyornithine lipid + CO2 + succinate => 2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19619", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74969", "l": "a (3R)-3-isocyanyl-fatty acyl-AMP + diphosphate => a (3R)-3-isocyanyl-fatty acid + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44046", "l": "11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798749", "l": "Exocytosis of specific granule lumen proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26168", "l": "3-fumarylpyruvate + H2O = fumarate + H(+) + pyruvate", "d": []}, {"i": "EC:3.7.1.20", "l": "\"3-fumarylpyruvate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008388", "l": "testosterone 15-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201685", "l": "Beta-catenin is released from the destruction complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51833", "l": "ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55749", "l": "coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.344", "l": "\"dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67260", "l": "(E)-hept-2-enal + H2O + NAD(+) = (E)-hept-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102731", "l": "D-myo-inositol (1,3,4,6)-tetrakisphosphate 2-kinase activity", "d": ["Catalysis of the reaction: myo-inositol 1,3,4,6-tetrakisphosphate(8-) + ATP = H+ + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191072", "l": "Synthesis of Cx43 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2530445", "l": "CD59 inhibits MAC formation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354077", "l": "Integrin alphaIIb beta3 activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114552", "l": "Thrombin-activated PARs activate G12/13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72202", "l": "Ca(2+)(in) + 2 H(+)(out) <=> Ca(2+)(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21291", "l": "D-glucose + sn-glycerol 3-phosphate <=> D-glucose 6-phosphate + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65491", "l": "3 ATP <=> 2',3',3'-c-tri-AMP + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50102", "l": "CoA + H(+) + N-dodecanoyl-taurine => dodecanoyl-CoA + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700646", "l": "ASP-3026- resistant ALK mutants don't bind ASP-3026 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61370", "l": "4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate => 4-methylumbelliferone sulfate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73906", "l": "ATP + ethanolamine + L-glutamate <=> ADP + gamma-L-glutamylethanolamide + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17615", "l": "H(+) + NADH + scyllo-inosose => NAD(+) + scyllo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28349", "l": "7,8-dihydroneopterin 3'-triphosphate <=> 7,8-dihydromonapterin 3'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805059", "l": "CK2:FACT phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935930", "l": "miR-18a binds RUNX1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63311", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74839", "l": "UDP(in) + UDP-alpha-D-glucuronate(out) = UDP(out) + UDP-alpha-D-glucuronate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28519", "l": "D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-beta-D-manno-heptose 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64096", "l": "3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] = 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49159", "l": "dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine <=> dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.23", "l": "\"7-chloro-L-tryptophan oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26325", "l": "(8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine = (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.n7", "l": "\"5-pentadecatrienyl resorcinol O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429036", "l": "SLC2A9 transports Fru, Glc, urate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65858", "l": "a steroid 1,3-dione + AH2 => A + a 1-hydroxy-3-oxo steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30134", "l": "H2O + octanoyl-[ACP] <=> H(+) + holo-[ACP] + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71035", "l": "L-phenylalanine(out) + L-serine(in) = L-phenylalanine(in) + L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684169", "l": "G6B binds PTPN6,PTPN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35097", "l": "acetaldehyde + trimethylamine => choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19666", "l": "6-carboxyhexanoyl-CoA + NAD(+) => 6-carboxyhex-2-enoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65796", "l": "fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57400", "l": "3-O-acetylpapaveroxine + H2O = acetate + H(+) + narcotine hemiacetal", "d": []}, {"i": "EC:3.1.1.105", "l": "\"3-O-acetylpapaveroxine carboxylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44352", "l": "ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate = ADP + dapdiamide C + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20400", "l": "L-cysteine + O-succinyl-L-homoserine <=> H(+) + L,L-cystathionine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606602", "l": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102274", "l": "glutathione S-conjugate carboxypeptidase activity", "d": ["Catalysis of the reaction: H2O + a glutathione-toxin conjugate <=> glycine + a [Glu-Cys]-S-conjugate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14166", "l": "acetyl-CoA + L-aspartate => CoA + H(+) + N-acetyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534096", "l": "METAP1/2 demethylates GNAT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432054", "l": "Aquaporin-1 passively transports water out of cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36560", "l": "A + cis-4-hydroxy-D-proline => 4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34388", "l": "beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose => beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168885", "l": "Haptoglobin binds Hemoglobin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38514", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954117", "l": "E2F6:TFDP1 binds EPC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49407", "l": "beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate <=> alpha-D-mannose 1-phosphate + D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42537", "l": "uridine(65) in tRNA => pseudouridine(65) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53217", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868118", "l": "MAPK12 phosphorylates PTPN3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70241", "l": "PCK1 phosphorylates OA to yield PEP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619034", "l": "ACEIs translocate from ER lumen to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51180", "l": "cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24246", "l": "H(+) + NADPH + tropinone => NADP(+) + pseudotropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30633", "l": "beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19189", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2", "d": []}, {"i": "EC:1.2.4.1", "l": "\"pyruvate dehydrogenase (acetyl-transferring)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27942", "l": "(3R)-3-hydroxy-D-aspartate = NH4(+) + oxaloacetate", "d": []}, {"i": "EC:4.3.1.27", "l": "\"threo-3-hydroxy-D-aspartate ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23728", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = A + H2O + prostaglandin H2", "d": []}, {"i": "EC:1.14.99.1", "l": "\"prostaglandin-endoperoxide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4167511", "l": "HLCS biotinylates ACACB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432121", "l": "LDL binds to LRP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028598", "l": "Phosphorylation of YAP by LATS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55975", "l": "acetyl-CoA + ethanol <=> CoA + ethyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12449", "l": "(R)-pantothenate + H2O => (R)-pantoate + beta-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060698", "l": "endoribonuclease inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of endoribonuclease."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5444523", "l": "Formation of MSH1:PMS2 Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71249", "l": "beta-alanine(in) + chloride(in) + 2 Na(+)(in) => beta-alanine(out) + chloride(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204169", "l": "PDP dephosphorylates p-lipo-PDH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61181", "l": "quercetin + UDP-alpha-D-glucose => H(+) + quercetin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40552", "l": "demethylphylloquinol + S-adenosyl-L-methionine => H(+) + phylloquinol + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32867", "l": "myo-inositol(out) = myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028598", "l": "Phosphorylation of YAP by LATS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45726", "l": "(E)-4-coumaraldehyde + H(+) + NADPH => (E)-4-coumaroyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877281", "l": "PIAS1 binds p-STAT1 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12747", "l": "a 4-hydroxyacid + H(+) => a 1,4-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42634", "l": "5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174741", "l": "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578712", "l": "Importin-8 binds AGO2:miRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180008", "l": "RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 7) + H2O = RNA polymerase II large subunit + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75351", "l": "2 Fe(III)-[cytochrome c] + H2O + pseudooxynicotine = 4-oxo-4-(pyridin-3-yl)butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) + methylamine", "d": []}, {"i": "EC:1.4.2.3", "l": "\"TEMPLATE: pseudooxynicotine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30351", "l": "H(+) + NADH + O2 + pyrrole-2-carboxylate = 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.130", "l": "\"pyrrole-2-carboxylate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426263", "l": "Dystroglycan binds NRXN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14319", "l": "H(+) + morphinone + NADH => morphine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13407", "l": "CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide => 4-coumaroyl-CoA + agmatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679045", "l": "C-ter TLR9 dimer binds HCQ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757688", "l": "SERPINA6 binds PREDN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112265", "l": "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56420", "l": "apo-[D-alanyl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68294", "l": "CoA + O-nonanoyl-L-seryl-[protein] => L-seryl-[protein] + nonanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160013", "l": "NAD-dependent protein de-2-hydroxyisobutyrylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD+ = 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:24364", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) = 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26537", "l": "3-hydroxypropanoate + ATP + CoA <=> 3-hydroxypropanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419197", "l": "Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38192", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone => 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042767", "l": "ecdysteroid 22-hydroxylase activity", "d": ["Catalysis of the hydroxylation of an ecdysteroid at carbon position 22."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44277", "l": "eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102493", "l": "wogonin 7-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: wogonin + UDP-alpha-D-glucose <=> wogonin 7-O-beta-D-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874082", "l": "MET phosphorylates PTK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809764", "l": "SBF1 binds MTMR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-912627", "l": "CBL ubiquitinates PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19704", "l": "a flavonol 3-O-glycoside + UDP-alpha-D-xylose <=> a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70729", "l": "6-sulfo-alpha-D-quinovose + glycerol => 3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40953", "l": "acetate + L-2,4-diaminobutanoate => (2S)-2-acetamido-4-aminobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018458", "l": "isopiperitenol dehydrogenase activity", "d": ["Catalysis of the reaction: (1S,6R)-isopiperitenol + NAD+ = (6R)-isoperitenone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32392", "l": "(1R,2R,4R)-dihydrocarveol + NAD(+) => (1R,4R)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17060", "l": "a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28243", "l": "O2 + pratensein + reduced [NADPH--hemoprotein reductase] => 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29789", "l": "ADP + glutathione(out) + H(+) + phosphate => ATP + glutathione(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16058", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26047", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026366", "l": "NTF3-bound NTRK2 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51773", "l": "dimethylallyl diphosphate + phlorisobutanophenone => 4-prenylphlorisobutanophenone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75222", "l": "H2O + L-fucono-1,5-lactone <=> H(+) + L-fuconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35352", "l": "NADP(+) + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.160", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28770", "l": "ethylnitronate + O2 <=> acetaldehyde + chemical entity + H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.1.1", "l": "\"NAD(P)(+) transhydrogenase (Si-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41677", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + ATP => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17851", "l": "(2E)-butenoyl-CoA + H2O => (3R)-3-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45644", "l": "H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-hexadecanoylsphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18981", "l": "(R)-pantolactone + NADP(+) = 2-dehydropantolactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40873", "l": "(2E,9Z)-octadecadienoyl-CoA + FADH2 => (9Z)-octadecenoyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296421", "l": "NLRP3 oligomerizes via NACHT domains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46314", "l": "3,22-dioxochol-4-en-24-oyl-CoA + CoA => 3-oxochol-4-en-22-oyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.n2", "l": "\"fatty acyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30342", "l": "H(+) + L-tryptophan <=> CO2 + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42039", "l": "chenodeoxycholate + NAD(+) <=> 7-oxolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665998", "l": "MKL1 binds SRF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28147", "l": "geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] => 3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38429", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54800", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein] = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29648", "l": "alpha-maltopentaose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltotetraose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51543", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592297", "l": "Full activation of MMP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68232", "l": "L-cysteine(in) + Na(+)(in) = L-cysteine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-976801", "l": "Complement factor I complex formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209766", "l": "25(OH)D translocates from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46271", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29854", "l": "H2O + UDP-N-acetyl-alpha-D-galactosamine <=> 2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.62", "l": "\"subtilisin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12416", "l": "beta-alanyl-CoA = acryloyl-CoA + NH4(+)", "d": []}, {"i": "EC:4.3.1.6", "l": "\"beta-alanyl-CoA ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20235", "l": "a 7-oxosteroid + H(+) + NADPH => a 7beta-hydroxysteroid + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003735", "l": "structural constituent of ribosome", "d": ["The action of a molecule that contributes to the structural integrity of the ribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22440", "l": "UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine = H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP", "d": []}, {"i": "EC:2.7.8.18", "l": "\"UDP-galactose--UDP-N-acetylglucosamine galactose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12870", "l": "(2E)-geranyl diphosphate => (4S)-limonene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49102", "l": "5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester => H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110380", "l": "Dissociation of LIG3:XRCC1 complex from the BER site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34519", "l": "N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine = [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP", "d": []}, {"i": "EC:2.4.1.292", "l": "\"GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684006", "l": "KPNA2 translocates NBN to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50205", "l": "(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53809", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18356", "l": "ATP + H2O + K(+)(out) + Na(+)(in) <=> ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53434", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661625", "l": "FVIII is secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610717", "l": "PKA phosphorylates GLI2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052729", "l": "dimethylglycine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46706", "l": "2-hydroxybenzoyl-5'-AMP + diphosphate => ATP + H(+) + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801776", "l": "REG3A binds bacterial phospholipids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50924", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40089", "l": "22-oxodocosanoate + H(+) + NADH => 22-hydroxydocosanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032426", "l": "NTRK2 phosphorylates FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804596", "l": "APAF1:CYCS binds APIP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691204", "l": "TLR8 dimer binds TLR7, TLR8 ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59335", "l": "1'-hydroxy-gamma-carotene + A <=> 1'-hydroxytorulene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14948", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72435", "l": "(E)-caffeoyl-AMP + CoA = (E)-caffeoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45864", "l": "16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50396", "l": "(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA = 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O", "d": []}, {"i": "EC:2.3.1.230", "l": "\"2-heptyl-4(1H)-quinolone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33502", "l": "H(+) + prephenate <=> 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76466", "l": "CYP4A11 12-hydroxylates DDCX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37705", "l": "1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69701", "l": "beta-D-glucose + N-hexadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60912", "l": "cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65021", "l": "L-ornithine + succinyl-CoA => CoA + H(+) + N(2)-succinyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70798", "l": "H(+)(in) + L-lysine(out) <=> H(+)(out) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781840", "l": "ERCC6 binds stalled RNA Pol II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47341", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45367", "l": "H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine <=> (11Z)-eicosenoate + (4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25173", "l": "H2O + N(omega)-methyl-L-arginine = L-citrulline + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685011", "l": "ATR activation at DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748991", "l": "XDH oxidises 6MP to 6TU (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44594", "l": "2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44939", "l": "(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA <=> (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71433", "l": "3,3',5'-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out) => 3,3',5'-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25339", "l": "H(+) + urea => isocyanate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198621", "l": "AKT phosphorylates caspase-9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72054", "l": "butanoate(out) + estrone 3-sulfate(in) <=> butanoate(in) + estrone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29603", "l": "benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] = 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}, {"i": "EC:1.1.7.1", "l": "\"4-hydroxybenzoyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53110", "l": "2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine => 2-hydroxyestrone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13355", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+) => 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351341", "l": "Exocytosis of Proactivator polypeptide (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748996", "l": "GST dimers cleave AZA to 6MP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11608", "l": "[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110322", "l": "Formation of Pol zeta complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805109", "l": "CDK2 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209760", "l": "Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12948", "l": "2'-hydroxybiphenyl-2-sulfinate + H2O <=> biphenyl-2-ol + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49625", "l": "ATP + erythritol => ADP + D-erythritol 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56755", "l": "a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70270", "l": "hydrogencarbonate(in) + Na(+)(in) <=> hydrogencarbonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686071", "l": "GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174551", "l": "Formation of alternative pathway C5 convertase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026927", "l": "GGT hydrolyses RCTR1 to RCTR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46023", "l": "[pyruvate, water dikinase] + ADP <=> [pyruvate, water dikinase]-phosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21825", "l": "2-oxoglutarate + L-aspartate => L-glutamate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811412", "l": "Active ARF recruits coatomer to the Golgi (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71122", "l": "H(+) + hispidin + NADPH + O2 <=> 3-hydroxyhispidin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51561", "l": "(S)-bulbocapnine + S-adenosyl-L-methionine => (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73787", "l": "dimethylallyl diphosphate + tardioxopiperazine A = diphosphate + variecolorin L", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28789", "l": "4-(phosphooxy)-L-threonine + ADP + H(+) => 4-hydroxy-L-threonine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25532", "l": "ent-copalyl diphosphate = diphosphate + ent-cassa-12,15-diene", "d": []}, {"i": "EC:4.2.3.28", "l": "\"ent-cassa-12,15-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39180", "l": "(2E)-eicosenoyl-CoA + H(+) + NADPH => eicosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35487", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60263", "l": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350377", "l": "Extracellular domains of STAN bind to each other in adjacent cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11306", "l": "glyoxylate + urea => (S)-ureidoglycolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10697", "l": "a long-chain fatty acid + ATP + holo-[mycocerosate synthase] => AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32677", "l": "alpha-D-glucose + beta-D-glucose => alpha,alpha-trehalose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75814", "l": "acetoacetate(out) + Na(+)(out) <=> acetoacetate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27878", "l": "2',3'-cyclophospho-UMP + H2O = 3'-UMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-844438", "l": "NLRP1 oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050442", "l": "3-propylmalate synthase activity", "d": ["Catalysis of the reaction: glyoxylate + H2O + pentanoyl-CoA = 3-propylmalate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37308", "l": "glycyl-L-asparagine + H2O => glycine + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66697", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48653", "l": "lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41795", "l": "holo-[ACP] + malonyl-CoA <=> CoA + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74607", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-galactosamine(out) = UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-galactosamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33265", "l": "(E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757688", "l": "SERPINA6 binds PREDN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71477", "l": "L-isoleucyl-L-leucine + neurotensin(1-11) => H2O + neurotensin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0032139", "l": "dinucleotide insertion or deletion binding", "d": ["Binding to a double-stranded DNA region containing a dinucleotide insertion or deletion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168400", "l": "iE-DAP elicits a NOD1 response (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023846", "l": "Estrogen-responsive CTSD expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-379464", "l": "COMT transfers Met to DOPAC to form HVA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103057", "l": "gibberellin A19, 2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A19 + O2 + 2-oxoglutarate <=> H+ + gibberellin A20 + 2 carbon dioxide + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380949", "l": "AMPK is dephosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63705", "l": "mycophenolate + UDP-alpha-D-glucuronate => H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59694", "l": "D-cellotrionate + H(+) => D-cellotriono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1253343", "l": "WWOX binds ERBB4s80 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32208", "l": "(2E,4Z)-2-hydroxyhexa-2,4-dienedioate => (3Z)-2-oxohex-3-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350410", "l": "RHO1:GDP complex dissociates from RHOGAPP190 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23805", "l": "N-acetyl-alpha-D-glucosamine 1-phosphate => N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55612", "l": "an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + H2O = 1-methyladenine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17952", "l": "3-hydroxy-1H-quinolin-4-one + O2 <=> CO + H(+) + N-formylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22838", "l": "a 3-oxoacyl-[ACP] + CO2 + holo-[ACP] => a fatty acyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113402", "l": "Formation of DSIF:NELF:early elongation complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64008", "l": "(4R)-hydroxysphinganine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74657", "l": "H(+) + IDP + N-acetyl-D-glucosamine 6-phosphate => ITP + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16542", "l": "9-cis-violaxanthin + O2 => (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22142", "l": "a nucleoside + phosphate => a nucleoside 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730595", "l": "Phosphorylated STAT3 Forms Dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426146", "l": "SREBP1A,1C,2 binds the FDFT1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48078", "l": "4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde => a primary alcohol + N,N-dimethyl-4-nitrosoaniline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36347", "l": "N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine", "d": []}, {"i": "EC:4.1.3.44", "l": "\"tRNA 4-demethylwyosine synthase (AdoMet-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33182", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625901", "l": "CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392751", "l": "L1 linked to actin cytoskeleton by ankyrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008909", "l": "isochorismate synthase activity", "d": ["Catalysis of the reaction: chorismate = isochorismate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40607", "l": "1-tetradecanoyl-sn-glycerol + H2O = glycerol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51842", "l": "2 Na(+)(in) + tauroallocholate(in) => 2 Na(+)(out) + tauroallocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679266", "l": "Beclin-1 complex translocates to the ER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38093", "l": "beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine => delta-tocotrienol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.302", "l": "\"2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202203", "l": "Recruitment of PI3K to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23123", "l": "a dipeptide(out) + ATP + H2O <=> a dipeptide(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.881813014728969", "identifiers": [{"i": "GO:0140677", "l": "molecular function activator activity", "d": ["A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44628", "l": "L-dihydroanticapsin + NAD(+) = H(+) + L-anticapsin + NADH", "d": []}, {"i": "EC:1.1.1.385", "l": "\"dihydroanticapsin 7-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31257", "l": "3-hydroxy-3-methyl-2-oxobutanoate => (2S)-2-acetolactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623023", "l": "AGRP gene expression is stimulated by FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20214", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein] => L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987039", "l": "JAK1 binds IL20RA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66217", "l": "asc-C7-CoA + O2 => asc-DeltaC7-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730599", "l": "Phosphorylated STAT3 Dimer Translocates to the Nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23183", "l": "a secondary alcohol + O2 <=> a ketone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15745", "l": "[(2->1)-beta-D-fructosyl](n) + sucrose = [(2->1)-beta-D-fructosyl](n+1) + D-glucose", "d": []}, {"i": "EC:2.4.1.9", "l": "\"inulosucrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0018822", "l": "nitrile hydratase activity", "d": ["Catalysis of the reaction: an aliphatic amide = a nitrile + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17408", "l": "N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine <=> H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.7", "l": "\"ADP deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018621", "l": "4-sulfobenzoate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: 4-sulfobenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + NAD+ + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17264", "l": "an aryl sulfate + H2O <=> a phenol + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.215", "l": "\"arabinogalactan exo alpha-(1,3)-alpha-D-galactosyl-(1->3)-L-arabinofuranosidase (non-reducing end)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41534", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9718360", "l": "GNRHR binds GNRHR peptide agonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928625", "l": "PAKs autophosphorylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40869", "l": "(2E,9E)-octadecadienoyl-CoA + FADH2 => (9E)-octadecenoyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799335", "l": "Synthesis of nascent polypeptide containing signal sequence (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651789", "l": "LIG1 bound to POLB ligates SSB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947499", "l": "Exchange of oxygen with sulfur in MoCo (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76426", "l": "N-atom dealkylation of caffeine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418456", "l": "cGMP is degraded by PDEs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69676", "l": "eriodictyol-7-O-beta-D-glucoside + H2O => (S)-eriodictyol + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "50.481605550987361", "identifiers": [{"i": "GO:0033218", "l": "amide binding", "d": ["Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15348", "l": "ATP + L-arginine + L-tyrosine <=> AMP + diphosphate + H(+) + L-tyrosyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48433", "l": "ATP + N(6)-D-ribulosyl-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62030", "l": "D-glucose + stigmasterol => H2O + stigmasteryl 3-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043772", "l": "acyl-phosphate glycerol-3-phosphate acyltransferase activity", "d": ["Catalysis of the reaction: acyl phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + orthophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428885", "l": "Activation of CLASP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390078", "l": "14-3-3 dimer binds to phosphorylated YKI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72318", "l": "glutathione(in) + leukotriene C4(out) <=> glutathione(out) + leukotriene C4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49993", "l": "H(+) + NADH + O2 + propane => H2O + NAD(+) + propan-2-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69452", "l": "3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH = 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59368", "l": "1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380930", "l": "Phosphorylated AMPK binds AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22244", "l": "kaempferol + UDP-alpha-D-xylose = H(+) + kaempferol 3-O-beta-D-xyloside + UDP", "d": []}, {"i": "EC:2.4.2.56", "l": "\"kaempferol 3-O-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446089", "l": "BP180 interacts extracellularly with Laminin 332 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015313", "l": "fluconazole:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44958", "l": "hexanoyl-CoA + NADP(+) => (2E)-hexenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60611", "l": "1-tetradecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50101", "l": "dodecanoyl-CoA + taurine => CoA + H(+) + N-dodecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033916", "l": "beta-agarase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product."]}, {"i": "EC:3.2.1.81", "l": "\"beta-agarase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30844", "l": "H2O + N-formylmaleamate => formate + H(+) + maleamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41728", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71569", "l": "5-O-(L-seryl)-dTMP in DNA + phosphate => 5-phosphomethyl-dUMP in DNA + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451418", "l": "Pellino ubiquitinates IRAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73113", "l": "ladanein + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + scutellarein 4'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49533", "l": "4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O => ethylene glycol + H(+) + terephthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47925", "l": "2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate => (2S)-3-sulfolactaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34980", "l": "H(+)(in) => H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67481", "l": "2-oxoglutarate + O2 + prekainate => CO2 + H2O + kainate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0034701", "l": "tripeptidase activity", "d": ["Catalysis of the hydrolysis of a tripeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66814", "l": "8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B => 5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62380", "l": "carbaryl + H(+) + H2O = 1-naphthol + CO2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38741", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25011", "l": "H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63517", "l": "biphenyl-2,2',3-triol + H(+) + NADH + O2 => biphenyl-2,2',3,3'-tetraol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16244", "l": "an NDP-alpha-D-glucose + D-fructose <=> a ribonucleoside 5'-diphosphate + H(+) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610270", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN3A (GRIN3A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45242", "l": "a (2E,4E)-(5,6-saturated)-dienoyl-CoA => a (3E,5Z)-dienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000401", "l": "open form four-way junction DNA binding", "d": ["Binding to a DNA segment containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55406", "l": "[phosphate](n+1) + UDP => [phosphate](n) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59681", "l": "D-maltopentaose + O2 => D-maltopentaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44452", "l": "3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27618", "l": "(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate = di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.1", "l": "\"atrolysin A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964280", "l": "Active Gq binds BTK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869683", "l": "oxPL binds LBP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51967", "l": "2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433542", "l": "Phosphorylation and activation of VAV1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52505", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => (9R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72933", "l": "atranorin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + proatranorin IV + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9035227", "l": "TXN2 binds CysS248-MPST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446634", "l": "IRAK4 is activated by autophosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41766", "l": "CMP + ganglioside GT3 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2562526", "l": "PLK1 phosphorylates OPTN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11925", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => globoside Gb3Cer (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018541", "l": "p-benzoquinone reductase (NADPH) activity", "d": ["Catalysis of the reaction: 1,4-benzoquinone + H+ + NADPH = hydroquinone + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69765", "l": "a medium chain fatty acid + 2 H(+) + NADH => a medium-chain fatty aldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43653", "l": "decanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxododecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67969", "l": "H2O + presqualene diphosphate => H(+) + phosphate + presqualene monophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52083", "l": "12-octadecanoyloxy-octadecanoate + H2O <=> 12-hydroxyoctadecanoate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75340", "l": "chloride(out) + nitrate(in) => chloride(in) + nitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977301", "l": "Histidine is decarboxylated to histamine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20974", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68901", "l": "4-methoxybenzoate + ATP + H(+) + NADPH => 4-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592252", "l": "Expression of TFB2M (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28336", "l": "dAMP + diphosphate + H(+) => dATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20755", "l": "A + 2 cob(II)alamin + 2 H(+) + 2 H2O <=> AH2 + 2 aquacob(III)alamin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870269", "l": "Gastrin binds to CCK-B receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.4", "l": "\"ribonuclease H\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982775", "l": "Growth hormone receptor dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683831", "l": "CCDC59 binds TTF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358791", "l": "Phosphorylation of USP8 by P-AKT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801762", "l": "REG3A oligomerize to form a pore complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55739", "l": "alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose <=> [(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050406", "l": "[acetyl-CoA carboxylase]-phosphatase activity", "d": ["Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56555", "l": "ATP + L-threonyl-[rhodopsin] <=> ADP + H(+) + O-phospho-L-threonyl-[rhodopsin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63993", "l": "5-fluorocytidine + ATP => 5-fluorocytidine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668545", "l": "NIK autophosphorylates on T559 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23051", "l": "(S)-3-hydroxybutanoate + 2-oxoglutarate <=> (R)-2-hydroxyglutarate + acetoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034538", "l": "3-methylsalicylaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 3-methylsalicylaldehyde + NAD+ = 3-methylsalicylate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692539", "l": "HRH1 binds HRH1 inverse agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61128", "l": "O2 + quercetin + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35937", "l": "2 AMP + brevianamide F + 2 diphosphate + 2 H(+) => 2 ATP + L-proline + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71006", "l": "L-histidine(in) + L-phenylalanine(out) <=> L-histidine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51881", "l": "3,4,6-trichlorocatechol + O2 => (2Z,4E)-2,3,5-trichloromuconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47533", "l": "chenodeoxycholate + NAD(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68329", "l": "(R)-4'-phosphopantetheine + H2O => (R)-pantetheine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41299", "l": "H2O + N-(9Z-octadecenoyl)-sphing-4-enine = (9Z)-octadecenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430158", "l": "p-SLP-76 binds VAV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419645", "l": "Dimerization of LIMK1 by Hsp90 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168312", "l": "Fusion of the influenza virion HA2 protein transmembrane domain to the host cell endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20207", "l": "cycasin + H(+) + UDP => methylazoxymethanol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202604", "l": "Formation of a heteromeric BMP receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.-", "l": "\"Oxo-acid-lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034237", "l": "protein kinase A regulatory subunit binding", "d": ["Binding to one or both of the regulatory subunits of protein kinase A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53938", "l": "19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786650", "l": "DDHD1,2 hydrolyse PA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18962", "l": "D-allose + L-lysyl-[protein] => H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32427", "l": "(1R,4S)-isodihydrocarvone + A = (S)-carvone + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28066", "l": "CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) = alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032778", "l": "P-type cobalt transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cobalt(out) = ADP + phosphate + cobalt(in)."]}, {"i": "RHEA:32779", "l": "ATP + Co(2+)(out) + H2O = ADP + Co(2+)(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211466", "l": "HNF1A-dependent synthesis of HNF4A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59341", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A => 1'-hydroxy-demethylspheroidene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39084", "l": "3-oxododecanedioyl-CoA + CoA => acetyl-CoA + decanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807585", "l": "BPI binds LPS on the bacterial surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31561", "l": "H(+) + L-galactono-1,4-lactone + NADH => L-galactose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0004697", "l": "protein kinase C activity", "d": ["Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507871", "l": "Aquaporins passively transport glycerol out of cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9710263", "l": "GZMB cleaves GSDME (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64526", "l": "2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] => (2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8943279", "l": "GGT dimers hydrolyse GSH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19645", "l": "a D-threo-aldose + NAD(+) = a D-threo-aldono-1,5-lactone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.122", "l": "\"D-threo-aldose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373746", "l": "SEMA4D interacts with CD45 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11075", "l": "anthranilate + 3 H(+) + NADPH + O2 <=> catechol + CO2 + NADP(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49594", "l": "(3S)-3-hydroxybutanoyl-CoA => 2-hydroxyisobutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103067", "l": "4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity", "d": ["Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451309", "l": "Edited Kainate Receptor binds glutamate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350604", "l": "Agmatine + H2O <=> putrescine + urea (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.3.10", "l": "\"N-acetylglucosaminide alpha-(2,6)-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624112", "l": "CEBPA binds CDK4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61548", "l": "ent-kaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-7alpha-hydroxykaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176318", "l": "Loading of claspin onto DNA during replication origin firing (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48910", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23861", "l": "acetyl-CoA + deacetylcephalosporin C => cephalosporin C + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132088", "l": "Vitronectin prevents C9 polymerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52507", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (9R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20582", "l": "H2O + NAD(+) + NH4(+) => 2 H(+) + hydroxylamine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009045", "l": "xylose isomerase activity", "d": ["Catalysis of the reaction: D-xylose = D-xylulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-170149", "l": "Translocation of active Cdc25C to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56563", "l": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose <=> [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1297444", "l": "Binding of cAMP to HCN channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804527", "l": "INTL1 binds bacterial glycans (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814409", "l": "CK2 phosphorylates PDCL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72635", "l": "eIF4F binds to mRNP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709179", "l": "DPP4 binds DPP4 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54826", "l": "alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52506", "l": "(9R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19320", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate <=> 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40168", "l": "hexadecanoyl-CoA + O2 => (2E)-hexadecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30360", "l": "chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 => chlorophyllide b + 3 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56910", "l": "acetate + H(+) + thebaine => (7S)-O-acetylsalutaridinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112037", "l": "Inactivation of PLC beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20224", "l": "(6S)-5,6,7,8-tetrahydrofolate + ATP + formate <=> (6S)-10-formyltetrahydrofolate + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57840", "l": "1D-myo-inositol 1,3-bisphosphate + H2O = 1D-myo-inositol 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203613", "l": "depalmitoylation of eNOS (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43490", "l": "chlorophyll b + H(+) + NADH => 7(1)-hydroxychlorophyll a + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64510", "l": "2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + 4 CO2 + 5 CoA + H2O + S-adenosyl-L-homocysteine => acetyl-CoA + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19293", "l": "a monoacylglycerol + ATP = ADP + H(+) + monoacyl-sn-glycero-3-phosphate", "d": []}, {"i": "EC:2.7.1.94", "l": "\"acylglycerol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22205", "l": "3-hydroxyphenylacetate + H(+) + NADPH + O2 => H2O + homogentisate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990650", "l": "inositol-2,4,5,6-tetrakisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,6-trisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30827", "l": "UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30478", "l": "H2O + oroxylin A 7-O-beta-D-glucuronate <=> D-glucuronate + H(+) + oroxylin A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0016622", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a cytochrome."]}, {"i": "EC:1.2.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696356", "l": "OSCAR binds collagen and SP-D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54563", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP <=> a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174119", "l": "Free APC/C phosphorylated by Plk1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852331", "l": "GTSE1 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37200", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51740", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A = a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.32", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944254", "l": "Association of procollagen type XXVI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4225086", "l": "Defective mitochondrial BTD does not hydrolyse BCTN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65908", "l": "3-hydroxy-L-kynurenine + pyruvate = H2O + L-alanine + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658438", "l": "SPRED dimer binds NF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68362", "l": "dehydro-L-arabinono-1,4-lactone + H(+) + H2O2 => L-xylono-1,4-lactone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71885", "l": "H(+) + N(2)-(ADP-D-ribosyl)-GMP + nicotinamide => GMP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683792", "l": "p-T68-CHEK2 autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14069", "l": "D-fructose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.124", "l": "\"fructose 5-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58587", "l": "dihydroprecondylocarpine acetate <=> (-)-tabersonine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28253", "l": "acetyl-CoA + H(+) + malonyl-CoA <=> acetoacetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71505", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(out) => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19461", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73945", "l": "FAS-mediated dimerization of procaspase-8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865482", "l": "KMT2A (MLL) binds RUNX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30560", "l": "GTP + H2O => guanosine + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23643", "l": "1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 <=> CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73034", "l": "Cd(2+)(out) + H(+)(out) <=> Cd(2+)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.285", "l": "\"3''-deamino-3''-oxonicotianamine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66853", "l": "(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25770", "l": "3-carboxy-2-oxobutanoate + H(+) <=> 2-oxobutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13125", "l": "CoA + glutathione disulfide = CoA-glutathione + glutathione", "d": []}, {"i": "EC:1.8.4.3", "l": "\"glutathione--CoA-glutathione transhydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20691", "l": "(E)-caffeate + H(+) + L-quinate => chlorogenate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182990", "l": "Sprouty sequesters CBL away from active EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29270", "l": "L-valine(in) + Na(+)(in) <=> L-valine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35406", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) <=> (3R)-vestitone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420724", "l": "CASR binds Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928591", "l": "EPH:EFN tetramers oligomerise (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375302", "l": "Kinetochore capture of astral microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28930", "l": "3,4,5-trihydroxybenzoate + O2 <=> (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30388", "l": "GDP-alpha-D-glucose + phosphate => alpha-D-glucose 1-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782943", "l": "UV-DDB ubiquitinates XPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74716", "l": "Insulin binds the insulin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696267", "l": "RND3 binds GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824182", "l": "RBPJ:NICD1 and MSGN1 bind the LFNG gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54846", "l": "ethyl butanoate + H2O + NADP(+) => H(+) + hexan-3-one + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755304", "l": "MUL1 ubiquitinates UBXN7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183052", "l": "CBL binds to GRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218815", "l": "p-6Y-VEGFR2 binds NCK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0060590", "l": "ATPase regulator activity", "d": ["Binds to and modulates the activity of an ATP hydrolysis activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66273", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63076", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA = 2-acetylphloroglucinol + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31813", "l": "diphosphate + viridiflorene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102098", "l": "D-galacturonate reductase activity", "d": ["Catalysis of the reaction: L-galactonate + NADP = aldehydo-D-galacturonate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12288", "l": "an alpha-L-fucoside + H2O = an alcohol + L-fucose", "d": []}, {"i": "EC:3.2.1.51", "l": "\"alpha-L-fucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802911", "l": "High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-114284", "l": "Release of Cytochrome c from mitochondria (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001082", "l": "inulin binding", "d": ["Binding to inulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674385", "l": "p-T,Y MAPKs dimerize (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57918", "l": "4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+) => ATP + L-aspartyl-tRNA(Asn)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048040", "l": "UDP-glucuronate decarboxylase activity", "d": ["Catalysis of the reaction: H+ + UDP-alpha-D-glucuronate = CO2 + UDP-alpha-D-xylose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39931", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56230", "l": "(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63298", "l": "H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine => an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205244", "l": "Recruitment of CBL to KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41346", "l": "(5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12595", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9717841", "l": "holo-FDPS dimer binds NBPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156682", "l": "PLK1 phosphorylates NUDC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391211", "l": "Trace amine-associated receptors can bind trace amines (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56889", "l": "UDP-4-dehydro-6-deoxy-alpha-D-glucose => UDP-4-dehydro-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73309", "l": "H(+)(out) + L-aspartate(in) + phosphate(out) => H(+)(in) + L-aspartate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210430", "l": "Release of L-Glutamate at the synapse (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30003", "l": "alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose = alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15711", "l": "H(+) + kaempferol 3-O-beta-D-galactoside + UDP => kaempferol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70481", "l": "TPI1 isomerizes GA3P to DHAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24436", "l": "H2 + methanophenazine = dihydromethanophenazine", "d": []}, {"i": "EC:1.12.98.3", "l": "\"Methanosarcina-phenazine hydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033691", "l": "sialic acid binding", "d": ["Binding to a sialic acid, a N- or O- substituted derivative of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54413", "l": "a 3-oxo-5beta-steroid + NADP(+) => a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33614", "l": "H2O + methyl salicylate <=> H(+) + methanol + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49088", "l": "FAD + H(+) + H2O + squalene = FADH2 + hydroxysqualene", "d": []}, {"i": "EC:1.17.8.1", "l": "\"hydroxysqualene dehydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389980", "l": "unfolded actin/tubulin associates with prefoldin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27720", "l": "inosine + phosphate => H2O + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41518", "l": "H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase] => O2 + phylloquinone + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63992", "l": "5-fluorocytidine + ATP = 5-fluorocytidine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16158", "l": "2 Fe(III)-[leghemoglobin] + NADPH => 2 Fe(II)-[leghemoglobin] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030348", "l": "syntaxin-3 binding", "d": ["Binding to a syntaxin-3 SNAP receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65967", "l": "ATP + H2O + taurocholate(out) <=> ADP + H(+) + phosphate + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102901", "l": "isopimaradienol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + isopimaradienol + NADPH + O2 <=> isopimaradiene-diol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11039", "l": "a quaternary ammonium(out) + ATP + H2O <=> a quaternary ammonium(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11596", "l": "H(+) + orotidine 5'-phosphate = CO2 + UMP", "d": []}, {"i": "EC:4.1.1.23", "l": "\"orotidine-5'-phosphate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050121", "l": "N-acylglucosamine 2-epimerase activity", "d": ["Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62985", "l": "H2O + hexadecanamide => hexadecanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55282", "l": "13-cis-retinyl tetradecanoate + CoA => 13-cis-retinol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917693", "l": "ESCRT Disassembly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41160", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380203", "l": "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961632", "l": "POLA1 gene transcription is stimulated by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70011", "l": "2-aminobenzoyl-AMP + CoA = AMP + anthraniloyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008744", "l": "L-xylulokinase activity", "d": ["Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54085", "l": "7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine => archaeosine(15) in tRNA + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43394", "l": "1D-myo-inositol 1,3-bisphosphate + phosphate => 1D-myo-inositol 1,3,4-trisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39673", "l": "(9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O => (9Z)-hexadecenoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66742", "l": "ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate => ATP + H2O + N-acetyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21118", "l": "beta-D-glucose 1-phosphate + D-glucose => D-maltose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41550", "l": "8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine => 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61175", "l": "myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373177", "l": "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53074", "l": "2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66324", "l": "iodide(out) = iodide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163769", "l": "Activation of PP2A by Xylulose-5-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981353", "l": "RASA1 stimulates RAS GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18155", "l": "diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate => 2 GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070039", "l": "rRNA (guanosine-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429157", "l": "ABCC4 accumulation of dense granule contents (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010521", "l": "telomerase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of telomerase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2509838", "l": "ITPA hydrolyses dITP to dIMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47435", "l": "(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660752", "l": "USP9X deubiquitinates Ub-SNCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5226979", "l": "ADD1:ADD2 binds DMTN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69685", "l": "CHEK2 phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9623384", "l": "α1-agonists bind ADRA1A,B,D (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102673", "l": "fatty aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: NAD(1-) + H2O + a fatty aldehyde <=> NADH(2-) + 2 H+ + a fatty acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033726", "l": "aldehyde ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: an aldehyde + H2O + 2 oxidized ferredoxin = an acid + 2 H+ + 2 reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351341", "l": "Exocytosis of Proactivator polypeptide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26396", "l": "all-trans-zeaxanthin + 2 O2 <=> 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60323", "l": "N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606345", "l": "Recruitment of IRF3 to activated ZBP1:TBK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-933533", "l": "Dimerization of p-IRF7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29815", "l": "ATP + H2O + L-proline(out) = ADP + H(+) + L-proline(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32692", "l": "(2E)-geranyl diphosphate => (E)-beta-ocimene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759516", "l": "CDH11 variant mRNA is translated to CDH11 variant protein isoform (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66131", "l": "2-oxobutanoate + L-phenylalanine <=> (2S)-2-aminobutanoate + 3-phenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17835", "l": "3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine => 3-hydroxyanthranilate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11666", "l": "1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47570", "l": "ganglioside GD1b (d18:1(4E)) + H(+) + UDP => ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2731141", "l": "Syndecan-1 binds fibronectin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68238", "l": "L-glutamine(out) + Na(+)(out) => L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35918", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428750", "l": "Gq activation by TP receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51849", "l": "8-methylmenaquinone-6 + succinate => 8-methylmenaquinol-6 + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71159", "l": "H(+)(in) + L-serine(out) + Na(+)(out) = H(+)(out) + L-serine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69083", "l": "3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+) <=> 3,4-dihydroxyphenylacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71514", "l": "phylloquinone(out) <=> phylloquinone(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809254", "l": "MTMR8 binds MTMR9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689544", "l": "UCHL5 binds INO80 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10013", "l": "(R)-6-hydroxynicotine + H2O + O2 => 6-hydroxypseudooxynicotine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39302", "l": "(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64074", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O => acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201622", "l": "Caspase-mediated cleavage of gelsolin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.20", "l": "\"trans-1,2-dihydrobenzene-1,2-diol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433501", "l": "Interaction of other adapter proteins with p-KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871494", "l": "SORL1 binds APP(18-770) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296309", "l": "HCAR3 binds HCAR3 ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32882", "l": "(1R,4R,5R)-5-hydroxycamphor + NAD(+) <=> (1R,4R)-bornane-2,5-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71502", "l": "6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) <=> 6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44402", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-6 => 3-demethylubiquinol-6 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29861", "l": "5-deoxy-D-ribose + adenine => 5'-deoxyadenosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64908", "l": "CTP + 2 H2O = CMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52283", "l": "(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759158", "l": "SQSTM1 oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46714", "l": "H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42111", "l": "(20S)-hydroxypregn-4-en-3-one + NAD(+) <=> H(+) + NADH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0090600", "l": "alpha-1,3-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->3)-linked alpha-D-glucose residues with release of alpha-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11285", "l": "hydroxymalonate + NAD(+) => H(+) + NADH + oxomalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691167", "l": "CUL1, SKP1, FBXL5 bind (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21406", "l": "chlorite => chloride + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694392", "l": "3a translocates to the ERGIC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9676268", "l": "Formation of the MLL4 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169402", "l": "ISGylation of E2 conjugating enzymes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169406", "l": "ISGylation of host proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031832", "l": "type 6 serotonin receptor binding", "d": ["Binding to a type 6 serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32526", "l": "nigerose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018608", "l": "1-indanone dioxygenase activity", "d": ["Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3-hydroxy-1-indanone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19744", "l": "formyl-CoA + H2O <=> CoA + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11041", "l": "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate => 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192832", "l": "Initiation of cRNA Synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46309", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35847", "l": "ATP + sphing-4-enine = ADP + H(+) + sphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47379", "l": "(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10594", "l": "a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40065", "l": "2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA => 6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46131", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46765", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36850", "l": "FAD + L-threonyl-[protein] <=> AMP + FMN-L-threonyl-[protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47640", "l": "adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75338", "l": "bromide(in) + chloride(out) <=> bromide(out) + chloride(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853325", "l": "Plasma membrane FGFR1 fusions autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.201", "l": "\"2-methoxy-6-polyprenyl-1,4-benzoquinol methylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54880", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = (3R)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23967", "l": "(E)-coniferaldehyde + H2O + NADP(+) <=> (E)-ferulate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987039", "l": "JAK1 binds IL20RA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0055103", "l": "ligase regulator activity", "d": ["Binds to and modulates the activity of a ligase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31015", "l": "H(+) + indole-3-carboxylate = CO2 + indole", "d": []}, {"i": "EC:4.1.1.92", "l": "\"indole-3-carboxylate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954117", "l": "E2F6:TFDP1 binds EPC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352059", "l": "SLC6A15-mediated amino acid uptake (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70220", "l": "corticosterone + H(+) + NADPH => 20beta-dihydrocorticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0097643", "l": "amylin receptor activity", "d": ["Combining with amylin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158849", "l": "Phenol can form a sulfate conjugate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38941", "l": "diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose => dioscin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61369", "l": "4-methylumbelliferone sulfate(in) + ATP + H2O => 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15388", "l": "L-asparagine <=> 3-cyano-L-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21491", "l": "dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O <=> beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693111", "l": "RHOF auto-activates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16280", "l": "H2O + indole-3-acetaldehyde + O2 <=> (indol-3-yl)acetate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64847", "l": "(2E)-geraniol + benzoyl-CoA <=> (2E)-geranyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53955", "l": "4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate <=> 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636261", "l": "NOS2 gene produces NOS2 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429955", "l": "CCR4-NOT complex deadenylates mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17173", "l": "glutathionylspermidine + H2O = glutathione + spermidine", "d": []}, {"i": "EC:3.5.1.78", "l": "\"glutathionylspermidine amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611839", "l": "β3-agonists bind ADRB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876255", "l": "CBL recruits CIN85:endophilin complex to InlB-bound MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42735", "l": "guanosine(527) in 16S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10558", "l": "H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate => D-glyceraldehyde 3-phosphate + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48235", "l": "acetyl-CoA + L-glutamate 5-semialdehyde <=> CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35944", "l": "brevianamide F + dimethylallyl diphosphate => deoxybrevianamide E + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453358", "l": "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73518", "l": "UDP(out) + UTP(in) <=> UDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551570", "l": "VANGL2 is phosphorylated in response to WNT5A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66138", "l": "CoA + H(+) + N-acetyltyramine => acetyl-CoA + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68861", "l": "7-oxo-25-hydroxycholesterol + H(+) + NADPH => 7beta-25-dihydroxycholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106302", "l": "arachidonic acid 8,9-epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-8,9-epoxyeicosatrienoic acid."]}, {"i": "RHEA:64984", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68023", "l": "(2E)-geranyl phosphate + H2O <=> (2E)-geraniol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21094", "l": "dihydromacarpine + H(+) + S-adenosyl-L-homocysteine => 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050487", "l": "sulfoacetaldehyde acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl phosphate + sulfite = phosphate + sulfoacetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18407", "l": "H(+) + NADH + NH4(+) + pyruvate => H2O + L-alanine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43805", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30324", "l": "all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25359", "l": "(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] = biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.7.6", "l": "\"phycoerythrobilin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29582", "l": "Fe(2+)(in) + H(+)(in) <=> Fe(2+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0050498", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and the latter donor is dehydrogenated."]}, {"i": "EC:1.14.20.-", "l": "\"With 2-oxoglutarate as one donor, and the other dehydrogenated\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14607", "l": "alpha,alpha-trehalose 6-phosphate + GDP + H(+) => D-glucose 6-phosphate + GDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55414", "l": "[phosphate](n+1) + GDP => [phosphate](n) + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63480", "l": "NADP(+) + prostaglandin F2alpha = 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140032", "l": "glycosylation-dependent protein binding", "d": ["Binding to a protein upon glycosylation of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693061", "l": "STAMBP binds STAM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40142", "l": "(9Z)-octadecenoyl-CoA + H2O <=> (9Z)-octadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47532", "l": "chenodeoxycholate + NAD(+) = 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008926", "l": "mannitol-1-phosphate 5-dehydrogenase activity", "d": ["Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373748", "l": "SEMA4D interacts with CD72 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60452", "l": "2-hydroxyethane-1-sulfonate = acetaldehyde + H(+) + sulfite", "d": []}, {"i": "EC:4.4.1.38", "l": "\"isethionate sulfite-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62664", "l": "(2'R)-atrovenetin + S-adenosyl-L-methionine = deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21022", "l": "chorismate + phosphate => 5-O-(1-carboxyvinyl)-3-phosphoshikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31347", "l": "(+)-abscisic acid D-glucopyranosyl ester + H2O = 2-cis-(+)-abscisate + beta-D-glucose + H(+)", "d": []}, {"i": "EC:3.2.1.175", "l": "\"beta-D-glucopyranosyl abscisate beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201634", "l": "Caspase-mediated cleavage of FADK 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55201", "l": "5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine => 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21544", "l": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP", "d": []}, {"i": "EC:2.7.4.18", "l": "\"farnesyl-diphosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42986", "l": "diphosphate + pimara-8(14),15-diene => (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102125", "l": "gibberellin A9 16alpha,17 epoxidase activity", "d": ["Catalysis of the reaction: gibberellin A9 + O2 + H+ + NAD(P)H <=> 16alpha, 17-epoxy gibberellin A9 + H2O + NAD(P)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33196", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43845", "l": "(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 => (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50831", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 <=> (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.945916858897462", "identifiers": [{"i": "GO:0016840", "l": "carbon-nitrogen lyase activity", "d": ["Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)."]}, {"i": "EC:4.3.-.-", "l": "\"Carbon-nitrogen lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106430", "l": "dihydroorotate dehydrogenase (quinone) activity", "d": ["(S)-dihydroorotate + a quinone = orotate + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862380", "l": "HSD17B13 binds lipid droplets (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14133", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.103", "l": "\"tabersonine 16-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.20", "l": "\"deacetoxyvindoline 4-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.16", "l": "\"ABC-type ferric hydroxamate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33916", "l": "4-(methylamino)butanoate + H2O + O2 => H2O2 + methylamine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25451", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-guaia-6,9-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031722", "l": "hemoglobin beta binding", "d": ["Binding to a hemoglobin beta chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428625", "l": "Vesicular inhibitory amino acid transport (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160874", "l": "HYAL1 hydrolyses (HA)50 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16828", "l": "ATP + uridine <=> ADP + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73124", "l": "isorhamnetin + S-adenosyl-L-methionine => H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176452", "l": "Degradation of ubiquitinated SMAD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41480", "l": "an acyl-CoA + episterol = an episterol ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39988", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol => all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022186", "l": "SLC2A3 gene expression is stimulated by MECP2:CREB1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76026", "l": "18-hydroxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 18-oxocortisol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53993", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198714", "l": "ERK5 translocates to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40541", "l": "H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38154", "l": "carbonyl sulfide + H2O <=> CO2 + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052823", "l": "2-hydroxy-6-oxonona-2,4,7-trienedioate hydrolase activity", "d": ["Catalysis of the reaction: (2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16016", "l": "ATP + glycine + tRNA(Gly) <=> AMP + diphosphate + glycyl-tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031402", "l": "sodium ion binding", "d": ["Binding to a sodium ion (Na+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159796", "l": "Furin cleaves pro-factor IX to factor IX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936963", "l": "IRAK2 induces TRAF6 oligomerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29452", "l": "H2O + phosphonate => H2 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003829", "l": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016412", "l": "serine O-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74416", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76043", "l": "(S)-cis-N-methyltetrahydropalmatine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + muramine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29716", "l": "2-hydroxyethane-1-sulfonate + FMNH2 + O2 => FMN + glycolaldehyde + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72687", "l": "all-trans-retinol(out) = all-trans-retinol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41984", "l": "NAD(+) + propan-2-ol = acetone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690196", "l": "USP8 deubiquitinates RNF128 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10585", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH => 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36761", "l": "alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0051499", "l": "D-aminoacyl-tRNA deacylase activity", "d": ["Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011997", "l": "ESR1:ESTG, JUND:FOSB and Cohesin Complex bind distal enhancer elements in MYC gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6794347", "l": "Homer1,2,3 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71996", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O => diphosphate + preaspterpenacid acid I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67046", "l": "AH2 + chermesin D => A + asnovolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357472", "l": "PAK1-3 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43869", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in) => a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706315", "l": "Active FLT3 binds to SH2B3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18690", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41168", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22121", "l": "CoA + GTP + succinate => GDP + phosphate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44748", "l": "5-amino-1-(beta-D-ribosyl)imidazole + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.223", "l": "\"aminoimidazole riboside kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420975", "l": "Ca impermeable AMPA receptor ligand binding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33550", "l": "H2O + lanosteryl hexadecanoate <=> H(+) + hexadecanoate + lanosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38945", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76031", "l": "2 H2O2 => O2 + 2 H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866304", "l": "pre-VLDL binds lipids to form VLDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9035484", "l": "CysS248-MPST:TXN2 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0023025", "l": "MHC class Ib protein complex binding", "d": ["Binding to a class Ib major histocompatibility complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624668", "l": "CEBPA binds CDKN1A (p21) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102447", "l": "rhamnetin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> 7,3'-dimethylquercetin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696271", "l": "RND1 binds effectors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694527", "l": "Loss of SAR1B GTPase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689544", "l": "UCHL5 binds INO80 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654571", "l": "Activated FGFR1 binds FRS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60873", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O => a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755304", "l": "MUL1 ubiquitinates UBXN7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72722", "l": "eIF2 activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033852", "l": "thyroid-hormone transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + 3,5,3'-triiodo-L-thyronine = 3,5,3'-triiodothyropyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15718", "l": "daunorubicin + H(+) + NADPH + O2 => doxorubicin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63975", "l": "A + dihydropyriculol <=> AH2 + pyriculol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139893", "l": "Granzyme-B activates BID by cleavage (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617209", "l": "CEBPB gene transcription is enhanced by phospho-CREB1 and phospho-STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54759", "l": "deamido-NAD(+) + hydrogencarbonate <=> AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68687", "l": "3'-phosphoadenylyl sulfate + testosterone 17-O-(beta-D-glucuronate) <=> adenosine 3',5'-bisphosphate + H(+) + testosterone 17-O-(3-sulfo-beta-D-glucuronate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39530", "l": "(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH <=> (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35631", "l": "cyanidin + UDP-alpha-D-galactose = cyanidin 3-O-beta-D-galactoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.294", "l": "\"cyanidin 3-O-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72144", "l": "AH2 + GTP + S-adenosyl-L-methionine => 3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9700701", "l": "T-type VDCC bind T-type VDCC blockers (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24709", "l": "(6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51591", "l": "isopyridoxal + NAD(+) <=> 5-pyridoxolactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30285", "l": "(1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+) => (-)-trans-permethrin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35151", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) = (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046563", "l": "methanol oxidase activity", "d": ["Catalysis of the reaction: O2 + methanol = H2O2 + formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0005294", "l": "neutral L-amino acid secondary active transmembrane transporter activity", "d": ["Enables the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32045", "l": "2 ATP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35047", "l": "adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin", "d": []}, {"i": "EC:2.10.1.1", "l": "\"molybdopterin molybdotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48908", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38111", "l": "glycerol + NADP(+) = H(+) + L-glyceraldehyde + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047851", "l": "dicarboxylate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + an omega-dicarboxylic acid + CoASH= AMP + diphosphate + an omega-carboxyacyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34494", "l": "H2O + UDP-N,N'-diacetylbacillosamine <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018793", "l": "3,5-dibromo-4-hydroxybenzoate decarboxylase activity", "d": ["Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzoate + H+ = CO2 + 2,6-dibromophenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373707", "l": "Netrin-1 induced DCC clustering (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102774", "l": "p-coumaroyltriacetic acid lactone synthase activity", "d": ["Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + 3 malonyl-CoA( <=> p-coumaroyltriacetic acid lactone + 4 coenzyme A + 3 carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15556", "l": "1D-myo-inositol 1,4-bisphosphate + H2O <=> 1D-myo-inositol 4-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354124", "l": "Phosphorylation of pPTK2 by SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163798", "l": "Furin cleaves pro-protein Z to protein Z (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12096", "l": "H2O + N-benzylformamide = benzylamine + formate", "d": []}, {"i": "EC:3.5.1.91", "l": "\"N-substituted formamide deformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25820", "l": "H2O + O2 + spermidine = 4-aminobutanal + H2O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12308", "l": "(S)-2-amino-6-oxohexanoate + H2O + NAD(+) = 2 H(+) + L-2-aminoadipate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18322", "l": "2-oxoglutarate + L-leucine => 4-methyl-2-oxopentanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23357", "l": "ATP + L-seryl-[rhodopsin] => ADP + H(+) + O-phospho-L-seryl-[rhodopsin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37162", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018625", "l": "naphthalene 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0031593", "l": "polyubiquitin modification-dependent protein binding", "d": ["Binding to a protein upon poly-ubiquitination of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2032781", "l": "WWTR1 (TAZ) binds TEAD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11734", "l": "H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052765", "l": "reduced coenzyme F420 oxidase activity", "d": ["Catalysis of the reaction: 2 reduced coenzyme F420 + O2 = 2 coenzyme F420 + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74456", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36618", "l": "2-hydroxyoctadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947499", "l": "Exchange of oxygen with sulfur in MoCo (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44081", "l": "ATP + CoA + undecanoate => AMP + diphosphate + undecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24446", "l": "GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805470", "l": "AMPK phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017130", "l": "poly(C) RNA binding", "d": ["Binding to a sequence of cytosine residues in an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68348", "l": "ATP + GTP = diphosphate + pppA(2'-5')pG", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9754130", "l": "CDK4 inhibitors bind CDK4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9752951", "l": "LHX2, LDB1, and EBF1 bind Olfactory Receptor gene and intergenic olfactory enhancers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61871", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005052", "l": "peroxisome matrix targeting signal-1 binding", "d": ["Binding to a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928645", "l": "EPHB:NMDAR binds TIAM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-398185", "l": "LARG binds plexin B1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48173", "l": "ganglioside GM2 + H2O => N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28437", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + tetradecanoyl-[ACP] <=> ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21380", "l": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA", "d": []}, {"i": "EC:6.2.1.24", "l": "\"phytanate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55223", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9626928", "l": "CREBBP binds FOXO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31467", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose = bis(beta-D-glucosyl) crocetin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67620", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950637", "l": "Expression of cell division cycle 42 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19525", "l": "(2E,6E)-farnesyl diphosphate = (1S,8aR)-delta-cadinene + diphosphate", "d": []}, {"i": "EC:4.2.3.13", "l": "\"(+)-delta-cadinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23509", "l": "(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O => (7R)-7-aminocephalosporanate + glutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1912357", "l": "ITCH ubiquitinates DTX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43388", "l": "1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351901", "l": "Caspase-mediated cleavage of MST3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74055", "l": "D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53295", "l": "H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin <=> H(+) + N-carbamoyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1912357", "l": "ITCH ubiquitinates DTX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35444", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose => an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63141", "l": "H2O + N-tetracosanoyl-taurine => taurine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58211", "l": "A + dihydroalstonine <=> AH2 + alstonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58200", "l": "2-oxoglutarate + 6-aminohexanoate = 6-oxohexanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.116", "l": "\"6-aminohexanoate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015540", "l": "3-hydroxyphenyl propionate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-hydroxyphenyl propionate(out) + H+(out) = 3-hydroxyphenyl propionate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31811", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + viridiflorene", "d": []}, {"i": "EC:4.2.3.88", "l": "\"viridiflorene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24880", "l": "1-dehydro-L-sorbose + AH2 => A + L-sorbopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1977959", "l": "ERBB4 forms heterodimers with EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.286", "l": "\"chalcone 4'-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70971", "l": "citrate <=> isocitrate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74655", "l": "ITP + N-acetyl-D-glucosamine = H(+) + IDP + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001537", "l": "N-acetylgalactosamine 4-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612257", "l": "ADAP1 gene expression is inhibited by ERBB4s80 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31657", "l": "5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine => 4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43314", "l": "ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate => ATP + N-(hexanoyl)sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16055", "l": "H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48407", "l": "apo-[aryl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55164", "l": "a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 = H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25502", "l": "diphosphate + terpinolene => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13812", "l": "aspulvinone E + 2 dimethylallyl diphosphate <=> aspulvinone H + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48296", "l": "H2O + prostaglandin E2 1-glyceryl ester = glycerol + H(+) + prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16165", "l": "L-tryptophan + O2 = CO2 + H2O + indole-3-acetamide", "d": []}, {"i": "EC:1.13.12.3", "l": "\"tryptophan 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67540", "l": "(9Z)-hexadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672961", "l": "PP2A dephosphorylates inactive RAFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63234", "l": "NAD(+) + octanoyl-CoA => (2E)-octenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62908", "l": "nor-toralactone + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + toralactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17295", "l": "H2O + NAD(+) + precorrin-3B => 2 H(+) + NADH + O2 + precorrin-3A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30729", "l": "dADP + H(+) + phosphoenolpyruvate => dATP + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805399", "l": "TAF1 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46510", "l": "catechol + NAD(+) + nitrite => NADH + nitrobenzene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029473", "l": "Branching and elongation of mother and daughter filaments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25035", "l": "all-trans-retinal + H(+) + NADPH => all-trans-retinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18033", "l": "benzoate + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.92", "l": "\"benzoate 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809254", "l": "MTMR8 binds MTMR9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070728", "l": "leucine binding", "d": ["Binding to 2-amino-4-methylpentanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198611", "l": "AKT phosphorylates IKKalpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351948", "l": "Mitochondrial recruitment of Drp1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176116", "l": "Recruitment and activation of Chk1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43989", "l": "(2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2 => (2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9675214", "l": "Formation of the WRAD complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782890", "l": "LCMT2 methoxycarbonylates yW-58 yielding yW (wybutosine) at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56898", "l": "an acyl-AMP + diphosphate => a carboxylate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70026", "l": "4-hydroxy-L-proline(in) + Na(+)(in) <=> 4-hydroxy-L-proline(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63000", "l": "(11Z,14Z,17Z)-eicosatrienamide + H2O = (11Z,14Z,17Z)-eicosatrienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632766", "l": "TP53 stimulates SCO2 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129362", "l": "Fibrillin microfibril assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855648", "l": "SALM3 binds LAR-RPTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14173", "l": "dimethylallyl diphosphate + L-tryptophan = 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": []}, {"i": "EC:2.5.1.34", "l": "\"4-dimethylallyltryptophan synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450533", "l": "PKCdelta phosphorylates HuR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27457", "l": "3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679205", "l": "ULK1 phosphorylates Beclin-1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399712", "l": "Activation of Ca permeable AMPA receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65583", "l": "H2O + TTP <=> H(+) + phosphate + TDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210805", "l": "Removal of miRNA passenger strand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981926", "l": "RAC1 and CDC42 activate PAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70019", "l": "O2 + reduced [NADPH--hemoprotein reductase] + typhasterol = 7-oxatyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62062", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53614", "l": "CDP-D-ribulose + diphosphate => CTP + D-ribulose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810376", "l": "ING2 binds PI5P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42545", "l": "uridine(32) in tRNA => pseudouridine(32) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43131", "l": "guanosine(10) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.24", "l": "\"aminobenzoate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31946", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73442", "l": "(2S)-naringenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-carthamidin-4',7-dimethyl ether + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11102", "l": "2 propanal => 4-hydroxyhexan-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879562", "l": "SLCO2B1 has a narrow substrate specificity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13704", "l": "acetyl-CoA + L-homoserine <=> CoA + O-acetyl-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37685", "l": "1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71174", "l": "H(+)(in) + L-cysteine(out) + Na(+)(out) <=> H(+)(out) + L-cysteine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0042922", "l": "neuromedin U receptor binding", "d": ["Binding to one or more specific sites on a neuromedin U receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47924", "l": "2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate = (2S)-3-sulfolactaldehyde + pyruvate", "d": []}, {"i": "EC:4.1.2.58", "l": "\"2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18776", "l": "coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid protein] <=> Co(I)-[methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41395", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53558", "l": "18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033831", "l": "kojibiose phosphorylase activity", "d": ["Catalysis of the reaction: kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10533", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine => D-glyceraldehyde 3-phosphate + H2O + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112514", "l": "JAK activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61657", "l": "(2E,6E)-farnesol + ATP => (2E,6E)-farnesyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21351", "l": "8 H(+) + 10 malonyl-CoA <=> 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019211", "l": "phosphatase activator activity", "d": ["Binds to and increases the activity of a phosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36998", "l": "(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10749", "l": "H(+) + hydrogencarbonate => CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696547", "l": "STAMBPL1 is a deubiquitinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35164", "l": "H(+)(out) + minocycline(in) => H(+)(in) + minocycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11978", "l": "5a,11a-dehydrotetracycline + H2O + NADP(+) => anhydrotetracycline + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032557", "l": "pyrimidine ribonucleotide binding", "d": ["Binding to a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31196", "l": "(3S)-hydroxyoctanoyl-CoA + NAD(+) => 3-oxooctanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9634834", "l": "ACHEIs bind ACHE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833672", "l": "CDH11 forms heterotypic trans dimer with CDH8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61257", "l": "H2O + L-cysteine + O2 => 2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473596", "l": "Collagen type I degradation by MMP15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399930", "l": "Activation of PAK by Rac1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57371", "l": "H2O + NADPH <=> (6R)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69562", "l": "D-mannose(in) + H(+)(in) => D-mannose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53103", "l": "2-hydroxyestrone + S-adenosyl-L-methionine <=> 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42562", "l": "pseudouridine(27/28) in mitochondrial tRNA => uridine(27/28) in mitochondrial tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2768993", "l": "NOTCH1 PEST domain mutants bind JAG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183055", "l": "Binding of CBL to EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622630", "l": "FOXO3,FOXO4,(FOXO1) bind BCL6 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199935", "l": "MSK1 activates CREB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64425", "l": "H(+)(out) + L-leucyl-L-proline(out) => H(+)(in) + L-leucyl-L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033520", "l": "TYSND1 cleaves TYSND1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44343", "l": "(S)-2,3-diaminopropanoate + ATP + fumarate <=> AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63506", "l": "13-dihydrodaunorubicin + NADP(+) => daunorubicin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65123", "l": "H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione <=> L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30002", "l": "ATP + H2O + spermidine(out) <=> ADP + H(+) + phosphate + spermidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202510", "l": "Activation of TAK1-TAB2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15056", "l": "(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0033041", "l": "sweet taste receptor activity", "d": ["Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20273", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine", "d": []}, {"i": "EC:1.14.16.1", "l": "\"phenylalanine 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202534", "l": "Ubiquitination of NEMO by TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36947", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110322", "l": "Formation of Pol zeta complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615571", "l": "PTEN mRNA translation is inhibited by miR-137 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20374", "l": "ATP + CoA + propanoate => AMP + diphosphate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.64", "l": "\"inosine diphosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42016", "l": "cortisone + NAD(+) = 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37835", "l": "aklavinone + H(+) + NADPH + O2 = epsilon-rhodomycinone + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.180", "l": "\"aklavinone 12-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48872", "l": "a gentamycin + GTP = a gentamycin 2''-phosphate + GDP + H(+)", "d": []}, {"i": "EC:2.7.1.190", "l": "\"aminoglycoside 2''-phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49350", "l": "2-oxospirilloxanthin + H2O => 2,2-dihydroxyspirilloxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1370500", "l": "PRLR binds SCF beta-TrCP complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11990", "l": "1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine => 1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29926", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36359", "l": "2 a plastoquinone + 2 H2O + 4 hnu = 2 a plastoquinol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783530", "l": "gp130:JAKs bind CNTFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390649", "l": "CHRM1,3,5 bind acetylcholine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10738", "l": "an aldehyde + H(+) + NADH => a primary alcohol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66842", "l": "asperterpenoid B + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => asperterpenoid A + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033300", "l": "dehydroascorbic acid transmembrane transporter activity", "d": ["Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770187", "l": "S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18263", "l": "acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine => H2O + precorrin-5 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.1", "l": "\"heterotrimeric G-protein GTPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46904", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) = a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10705", "l": "ATP + L-valine + tRNA(Val) => AMP + diphosphate + L-valyl-tRNA(Val)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74819", "l": "glutathione(in) = glutathione(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37210", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45854", "l": "Co(II)-factor IV + S-adenosyl-L-homocysteine => Co(II)-factor III + H(+) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174446", "l": "Removal of remaining Flap from the C-strand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72917", "l": "D-fructopyranose(in) + Na(+)(in) => D-fructopyranose(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11862", "l": "ADP + H(+) + N(tele)-phospho-L-histidyl-[protein] => ATP + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52124", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16837", "l": "5'-acylphosphoadenosine + H2O = a carboxylate + AMP + 2 H(+)", "d": []}, {"i": "EC:3.6.1.20", "l": "\"5'-acylphosphoadenosine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72913", "l": "atranorin + S-adenosyl-L-homocysteine => proatranorin III + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21562", "l": "1,4-dithiothreitol + 2,3-epoxyphylloquinone => 3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33454", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] <=> AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170674", "l": "Dissociation of the Gi alpha:G olf complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944457", "l": "MAF1 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791116", "l": "Expression of DDX11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905574", "l": "ganglioside GM2 binding", "d": ["Binding to ganglioside GM2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15529", "l": "bis(2-ethylhexyl)phthalate + H2O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)", "d": []}, {"i": "EC:3.1.1.60", "l": "\"bis(2-ethylhexyl)phthalate esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419861", "l": "Melanospin is stimulated by light (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451366", "l": "Activation of p38MAPK by DSCAM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62566", "l": "(4S)-perillyl alcohol + AH2 => (4S)-limonene + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48537", "l": "1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O => 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3240957", "l": "Formation of PRC2-EZH2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36024", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30721", "l": "2-methyl-3-oxobutanoyl-CoA + CoA => acetyl-CoA + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64696", "l": "benzyl alcohol + NAD(+) = benzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5627775", "l": "Autophosphorylation of PAK1,2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043924", "l": "suramin binding", "d": ["Binding to suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047619", "l": "acylcarnitine hydrolase activity", "d": ["Catalysis of the reaction: O-acylcarnitine + H2O = a fatty acid + L-carnitine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62341", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) => (+)-malbrancheamide C + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263495", "l": "Defective GNS does not hydrolyse 6-sulfate from GlcNAc6S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11874", "l": "18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin] => corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46001", "l": "adenosine + H(+) + tuberculosinyl diphosphate => 1-tuberculosinyladenosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444523", "l": "CXCR5 binds CXCL13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63416", "l": "2,6-dichlorohydroquinone + FADH2 + O2 = 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858346", "l": "AMHR2 binds AMH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009671", "l": "nitrate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33600", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008745", "l": "N-acetylmuramoyl-L-alanine amidase activity", "d": ["Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986258", "l": "SLIT2:ROBO1 binds CXCR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757256", "l": "MCM3 binds MCM5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866851", "l": "CFTR transits to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388809", "l": "CTLA-4 binds B7-1/B7-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29316", "l": "alpha-D-galactose 1-phosphate + H2O => D-galactose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.264511229695032", "identifiers": [{"i": "GO:0004030", "l": "aldehyde dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033486", "l": "Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199518", "l": "C3d-complexed antigen binds to complement receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22986", "l": "N-carbamoyl-2-oxoglycine + phosphate => carbamoyl phosphate + oxamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56544", "l": "H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193695", "l": "IRAK interacts with TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683888", "l": "LMCD1 binds GATA6, sequestering it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51918", "l": "2-oxobutanoate + NH4(+) => (2S)-2-amino-3-butenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110219", "l": "Cleavage of thymine by TDG glycosylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0046974", "l": "histone H3K9 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of up to three methyl groups to the lysine residue at position 9 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29479", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-epicubenol + diphosphate", "d": []}, {"i": "EC:4.2.3.64", "l": "\"(+)-epicubenol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20929", "l": "[DsbA protein]-dithiol + a quinone => [DsbA protein]-disulfide + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871265", "l": "YAP1 binds TEAD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52941", "l": "chenodeoxycholate + UDP-alpha-D-glucuronate => chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50666", "l": "an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247849", "l": "WLS dissociates from retromer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805035", "l": "TP53 binds STK11 and NUAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72304", "l": "L-glutamate(in) + L-thyroxine(out) => L-glutamate(out) + L-thyroxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371527", "l": "HSF1 trimer translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72999", "l": "H2O + N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide] = L-tryptophan + N-terminal L-alpha-aminoacyl-[peptide]", "d": []}, {"i": "EC:3.4.11.17", "l": "\"tryptophanyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129362", "l": "Fibrillin microfibril assembly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604308", "l": "NICD4 traffics to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41378", "l": "1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.37", "l": "\"aldose-1-phosphate nucleotidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53922", "l": "ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein] => ATP + L-threonyl-[Fas-activated protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56403", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71961", "l": "3 Na(+)(in) + oxaloacetate(in) => 3 Na(+)(out) + oxaloacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48156", "l": "ganglioside GQ1b (d18:1(4E)) + H2O = ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48970", "l": "[thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O => [thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018454", "l": "acetoacetyl-CoA reductase activity", "d": ["Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25062", "l": "3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) = 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34645", "l": "3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869566", "l": "The MYBL2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004044", "l": "amidophosphoribosyltransferase activity", "d": ["Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912503", "l": "Formation of meiotic single-stranded DNA invasion complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956649", "l": "The complex of RUNX1 and YAP1 binds the ITCH gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32401", "l": "(1S,4S)-dihydrocarvone + H(+) + NADH => (1S,2R,4S)-neodihydrocarveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0036318", "l": "peptide pheromone receptor activity", "d": ["Combining with a peptide pheromone, and transmitting the signal across the membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47799", "l": "an aralkylamine + H2O + 2 oxidized [azurin] <=> an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61638", "l": "AMP + diphosphate + isophthalyl-CoA => ATP + CoA + isophthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2730835", "l": "Autophosphorylation of PKC-theta (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448632", "l": "IL34 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70760", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45921", "l": "16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69895", "l": "cytidine(out) + Na(+)(out) = cytidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018814", "l": "RHOT1 hydrolyzes GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34639", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 = H2O + NADP(+) + neopentalenolactone D", "d": []}, {"i": "EC:1.14.13.171", "l": "\"neopentalenolactone D synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018561", "l": "2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2'-aminobiphenyl-2,3-diol + O2 = H+ + 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990300", "l": "cellulosome binding", "d": ["Binding to a cellulosome, an extracellular multi-enzyme complex containing several enzymes aligned on a non-catalytic scaffolding that functions to hydrolyze plant cell wall polysaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25927", "l": "A + H2O + quinolin-8-ol <=> 8-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10993", "l": "glycolate + NADP(+) => glyoxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25714", "l": "L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16844", "l": "precorrin-2 + S-adenosyl-L-methionine <=> H(+) + precorrin-3A + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507868", "l": "Aquaporins passively transport water into cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61486", "l": "a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2404144", "l": "Parenchymal atROL translocates to HSCs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482772", "l": "Release of platelet cytosolic components (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45524", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin alpha-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin alpha-subunit]", "d": []}, {"i": "EC:4.4.1.32", "l": "\"C-phycocyanin alpha-cysteine-84 phycocyanobilin lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54785", "l": "Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide => Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050008", "l": "isopiperitenone delta-isomerase activity", "d": ["Catalysis of the reaction: isopiperitenone = piperitenone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665761", "l": "FMNL3 binds RHOC:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70692", "l": "ornithine => putrescine + CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58989", "l": "(E)-4-hydroxynon-2-enal + H2O + O2 => (E)-4-hydroxynon-2-enoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23089", "l": "ATP + O-alkylglycerone => 1-O-alkylglycerone 3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70709", "l": "6-sulfo-D-rhamnose => 6-sulfo-beta-D-quinovose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17782", "l": "H2O + N-formyl-L-methionine => formate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19830", "l": "a primary alcohol + O2 => an aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64806", "l": "CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine => acetyl-CoA + S-(2-aminoethyl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39720", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate => 24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199910", "l": "MSK1 activates ATF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46502", "l": "CO2 + phosphate + succinate + uridine-5'-aldehyde => 2-oxoglutarate + O2 + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31317", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+) => (2R)-3-phosphoglycerate + GDP-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74589", "l": "(+)-exo-beta-bergamotene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11472", "l": "an N-methyl-L-amino acid + H2O + O2 = an L-alpha-amino acid + formaldehyde + H2O2", "d": []}, {"i": "EC:1.5.3.2", "l": "\"N-methyl-L-amino-acid oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37047", "l": "H(+)(out) + L-histidine(out) = H(+)(in) + L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66290", "l": "a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12637", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.50", "l": "\"procollagen galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59404", "l": "L-homoserine = D-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57535", "l": "a 5'-end ribonucleotide-RNA + ATP + H(+) <=> a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47852", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051753", "l": "mannan synthase activity", "d": ["Catalysis of the reaction: mannan(n) + GDP-mannose = mannan(n+1) + GDP. This reaction is the formation of the beta-(1->4)-linked mannan backbone in substrates such as galactomannan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10121", "l": "adenosine in double-stranded RNA + H(+) + H2O => inosine in double-stranded RNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102699", "l": "2-methylpropionitrile hydroxylase activity", "d": ["Catalysis of the reaction: H+ + 2-methylpropionitrile + O2 + NADPH <=> 2-hydroxy-2-methylpropanenitrile + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247497", "l": "ERBB3 binds neuregulins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63161", "l": "H2O + N-(15Z-tetracosenoyl)-taurine => (15Z)-tetracosenoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59179", "l": "ADP + L-serine <=> AMP + H(+) + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050022", "l": "L-arabinose 1-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.5", "l": "\"ribonuclease D\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673761", "l": "Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43540", "l": "ATP + L-seryl-[isocitrate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]", "d": []}, {"i": "EC:2.7.11.5", "l": "\"[isocitrate dehydrogenase (NADP(+))] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43613", "l": "S-adenosyl-L-methionine + uridine(341) in tmRNA => 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12912", "l": "2 Fe(II)-[cytochrome] + 2 H(+) + nitrate <=> 2 Fe(III)-[cytochrome] + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36949", "l": "3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727819", "l": "TAK1 phosphorylates MKK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189406", "l": "4 PBGs bind to form HMB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201639", "l": "Caspase-mediated cleavage of GAS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10040", "l": "adenosine 3',5'-bisphosphate + H2O = AMP + phosphate", "d": []}, {"i": "EC:3.1.3.7", "l": "\"3'(2'),5'-bisphosphate nucleotidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58180", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH = all-trans-lycopaoctaene + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70490", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O + O2 <=> a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606807", "l": "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11305", "l": "(S)-ureidoglycolate => glyoxylate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18660", "l": "(R)-glycerate + NADP(+) <=> 3-hydroxypyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12932", "l": "2-oxoglutarate + acetyl-CoA + H2O <=> (2R)-homocitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37776", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA => 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159773", "l": "Furin cleaves pro-protein S to protein S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76100", "l": "a dicarboxylate(in) + xanthurenate(out) => a dicarboxylate(out) + xanthurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70028", "l": "N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20805", "l": "2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) => H(+) + hydrogencarbonate + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295622", "l": "SPRY2 binds CBL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41956", "l": "2',3'-cyclophospho-CMP + H2O = cytidine 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36768", "l": "2-hydroxytetracosenoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109860", "l": "MAP2K1 phosphorylates MAPK3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39600", "l": "3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390425", "l": "FAR1 reduces PalmCoA to HXOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75486", "l": "estrone 3-sulfate(out) + n H(+)(out) <=> estrone 3-sulfate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70008", "l": "anthranilate + ATP + H(+) => 2-aminobenzoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30243", "l": "4 L-ascorbate + O2 = 2 H2O + 4 monodehydro-L-ascorbate radical", "d": []}, {"i": "EC:1.10.3.3", "l": "\"L-ascorbate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373734", "l": "Nephrin interacts with Podocin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951966", "l": "EP300 acetylates RUNX3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534378", "l": "Hv1 Mediated H+ Permeability (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50008", "l": "6-methylpretetramide + 2 H(+) + NADPH + O2 = 4-hydroxy-6-methylpretetramide + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.232", "l": "\"6-methylpretetramide 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38245", "l": "1-O-eicosanyl (9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + eicosan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56675", "l": "dihydro-4-coumaroyl-CoA + NADP(+) <=> (E)-4-coumaroyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031750", "l": "D3 dopamine receptor binding", "d": ["Binding to a D3 dopamine receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097261", "l": "eoxin C4 synthase activity", "d": ["Catalysis of the reaction: eoxin A4 + glutathione = eoxin C4."]}, {"i": "REACT:R-HSA-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951676", "l": "RUNX3 binds TEADs and YAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043849", "l": "Ras palmitoyltransferase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031847", "l": "type 1 neurotensin receptor binding", "d": ["Binding to a type 1 neurotensin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392064", "l": "G alpha (z) inhibits adenylate cyclase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987007", "l": "p-STAT1 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.-", "l": "\"Transferring alkyl or aryl groups, other than methyl groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801776", "l": "REG3A binds bacterial phospholipids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647978", "l": "pro-RAS proteins are farnesylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35470", "l": "(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71921", "l": "3 Na(+)(in) + succinate(in) => 3 Na(+)(out) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33919", "l": "H(+) + lanosterol + NADPH = 24,25-dihydrolanosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65986", "l": "lumisterol 3 => hnu + previtamin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74279", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IVA = a 2-acyl-sn-glycero-3-phosphocholine + a lipid IVB", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033443", "l": "AAA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AAA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798749", "l": "Exocytosis of specific granule lumen proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10618", "l": "(2R,3S,4S)-leucocyanidin + H(+) + NADPH => (2R,3S)-catechin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9770119", "l": "Formation of the Spliceosomal E complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851352", "l": "CCR8 binds CCL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19270", "l": "2-furoate + ATP + CoA => 2-furoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132100", "l": "Fluid-phase proteolytic cleavage of factor B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22806", "l": "(6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH => (6S,9R)-vomifoliol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26393", "l": "all-trans-zeaxanthin + 2 O2 = 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": []}, {"i": "EC:1.14.99.n4", "l": "\"carotenoid 9,10-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74445", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in) => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22298", "l": "(1R,2R,3R)-prephytoene diphosphate + diphosphate => 2 (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445704", "l": "Calcium Binds Caldesmon (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24765", "l": "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71703", "l": "taurocholate(out) = taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784765", "l": "p-Y705-STAT3 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67829", "l": "a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine => a lipid A disaccharide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689861", "l": "Recruitment of XPA and release of CAK  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48146", "l": "ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate => H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350158", "l": "LGMN degrades GC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70899", "l": "histidine => urocanate + NH4+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33674", "l": "an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O <=> 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52087", "l": "13-octadecanoyloxy-octadecanoate + H2O <=> 13-hydroxy-octadecanoate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534365", "l": "Slo3 Potassium Transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61975", "l": "1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42102", "l": "6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate => ATP + carbamoyl phosphate + H2O + kanamycin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40410", "l": "1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62171", "l": "H2O + N,N'-diacetylchitobiose <=> acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12141", "l": "a 2'-deoxyribonucleoside + ATP => a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-481009", "l": "Exocytosis of platelet dense granule content (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74577", "l": "N(alpha)-acetyl-L-methionine + N-terminal L-glutamyl-[protein] => H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043840", "l": "branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity", "d": ["Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-phenylalanine = phenylpyruvate + L-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-517705", "l": "p-S318,221-HuR binds mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213017", "l": "Auto-ubiquitination of TRAF3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49063", "l": "a long-chain alkane + FMNH2 + O2 <=> a long chain fatty alcohol + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.843050782660015", "identifiers": [{"i": "GO:0001217", "l": "DNA-binding transcription repressor activity", "d": ["A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070280", "l": "pyridoxal binding", "d": ["Binding to pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde, a form of vitamin B6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052830", "l": "inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate."]}, {"i": "REACT:R-HSA-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0099095", "l": "ligand-gated monoatomic anion channel activity", "d": ["Enables the transmembrane transfer of an inorganic anion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570573", "l": "Defective RFT1 does not flip the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853745", "l": "RET binds GFRA1,GFRA3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33125", "l": "(R)-tetraprenyl-beta-curcumene + diphosphate => all-trans-heptaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381644", "l": "ER calcium channels open in response to activated PKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48122", "l": "ganglioside GM3 + N-acetylneuraminate => ganglioside GD3 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24527", "l": "20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139920", "l": "Translocation of tBID to mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51436", "l": "acetyl-CoA + D-alanine = (2R)-2-amino-4-oxopentanoate + CoA", "d": []}, {"i": "EC:2.3.1.263", "l": "\"2-amino-4-oxopentanoate thiolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71018", "l": "H2O + N-methylputrescine + O2 <=> 4-methylaminobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53390", "l": "5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP => 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009392", "l": "N-acetyl-anhydromuramoyl-L-alanine amidase activity", "d": ["Catalysis of the reaction: GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-DAP-D-Ala + H2O glcNAc-1,6-anhMurNAc + L-Ala-gamma-D-Glu-DAP-D-Ala."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047181", "l": "tetrahydroxybenzophenone synthase activity", "d": ["Catalysis of the reaction: 3-hydroxybenzoyl-CoA + 3 malonyl-CoA = 3 CO2 + 2,3',4,6-tetrahydroxybenzophenone + 4 coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19585", "l": "lithocholate + NAD(+) = 3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.52", "l": "\"3alpha-hydroxycholanate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0003920", "l": "GMP reductase activity", "d": ["Catalysis of the reaction: IMP + NADP+ + NH4 = GMP + 2 H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420243", "l": "GHRH receptor binds GHRH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35318", "l": "H(+) + hexadecanoyl-CoA + malonyl-CoA <=> 3-oxooctadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19757", "l": "(3R)-3-hydroxy-L-aspartate = NH4(+) + oxaloacetate", "d": []}, {"i": "EC:4.3.1.20", "l": "\"erythro-3-hydroxy-L-aspartate ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19820", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69352", "l": "2 (E)-prop-1-en-1-SO-peroxol = H2O + thiosulfinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37952", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35780", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => mutildienyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868118", "l": "MAPK12 phosphorylates PTPN3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9709547", "l": "ESTG binds ESR2:chaperone complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28856", "l": "H(+)(in) + melibiose(in) => H(+)(out) + melibiose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850534", "l": "PDCL promotes G-protein beta 5 folding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187661", "l": "Ade-Rib binds AODORA2A and NTRK1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36586", "l": "dTDP-alpha-D-fucose + NADP(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730840", "l": "Activation of RAC1 by VAV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034582", "l": "3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-4-methyloctanoyl-CoA = 4-methyl-3-oxooctanoyl-CoA + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75459", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18078", "l": "L-arginyl-[dinitrogen reductase] + NAD(+) => H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50421", "l": "L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] => H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72670", "l": "O2 + reduced [NADPH--hemoprotein reductase] + secologanin <=> 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + secoxyloganin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0015343", "l": "siderophore-iron transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70692", "l": "ornithine => putrescine + CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19835", "l": "(6S)-5,6,7,8-tetrahydrofolate + formate + H(+) => (6S)-10-formyltetrahydrofolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-706479", "l": "TAK1 is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46919", "l": "H2O + juvenile hormone I <=> H(+) + juvenile hormone I carboxylate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48921", "l": "ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74711", "l": "5-dehydro-6-demethoxy-6-hydroxyfumagillol + S-adenosyl-L-methionine = 5-dehydrofumagillol + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.387", "l": "\"5-dehydro-6-demethoxy-6-hydroxyfumagillol O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614591", "l": "Excess cysteine yields lanthionine and H2S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72672", "l": "The 60S subunit joins the translation initiation complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24036", "l": "a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP", "d": []}, {"i": "EC:2.7.4.4", "l": "\"nucleoside-phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374723", "l": "Nociceptin receptor binds to nociceptin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40995", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA = 4-hydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57399", "l": "(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine <=> 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39304", "l": "(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA => (2E,11Z,14Z)-eicosatrienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109701", "l": "PDPK1 binds PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10294", "l": "CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate => acetyl-CoA + D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14535", "l": "creatine => creatinine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43796", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45300", "l": "an N-(acyl)-sphingosylphosphocholine + H2O = an N-acyl-sphingoid base + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67133", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH => (1S,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57779", "l": "2-chloro-6-nitrotoluene + NADH + O2 <=> 4-chloro-3-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981622", "l": "Myoglobin:oxygen dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70460", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2 => a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48536", "l": "1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O = 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58982", "l": "3,7-dimethylocta-2,6-dienoate + H(+) + H2O2 => citral + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56816", "l": "a pyrimidine ribonucleoside + H2O = a pyrimidine nucleobase + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64557", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one => 8-epi-ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72488", "l": "citrate(out) + phosphoenolpyruvate(in) => citrate(in) + phosphoenolpyruvate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62852", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473596", "l": "Collagen type I degradation by MMP15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71313", "l": "chloride(in) + L-alanine(in) + 2 Na(+)(in) => chloride(out) + L-alanine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28811", "l": "2,3-dioxo-L-gulonate(in) + Na(+)(in) = 2,3-dioxo-L-gulonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67293", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one => (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008109", "l": "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62455", "l": "ATP + holo-[peptidyl-carrier protein] + L-glutamate <=> AMP + diphosphate + L-glutamyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031531", "l": "thyrotropin-releasing hormone receptor binding", "d": ["Binding to a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473596", "l": "Collagen type I degradation by MMP15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665315", "l": "ERBB2 T733I does not bind tesevatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74986", "l": "Elongation of pre-rRNA transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164507", "l": "CD4:gp120  binds to chemokine co-receptor CCR5/CXCR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604368", "l": "Autocatalytic activation of bound proMMP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090079", "l": "GLB1 hydrolyses linker chain(2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75891", "l": "Abortive Initiation After Second Transition (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015425", "l": "ATPase-coupled nonpolar-amino acid transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420121", "l": "SFKs phosphorylate PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047525", "l": "2'-hydroxydaidzein reductase activity", "d": ["Catalysis of the reaction: 2'-hydroxydihydrodaidzein + NADP+ = 2'-hydroxydaidzein + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36939", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA = (9Z)-tetradecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23662", "l": "N-formimidoyl-L-glutamate => 4-imidazolone-5-propanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446372", "l": "Association of  PARVA with TESK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844438", "l": "NLRP1 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015110", "l": "cyanate transmembrane transporter activity", "d": ["Enables the transfer of cyanate, NCO-, the anion of cyanic acid, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62646", "l": "(5S)-hydroperoxy-(6E,8Z)-eicosadienoate => (5Z,8Z)-eicosadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22773", "l": "L-fuconate => 2-dehydro-3-deoxy-L-fuconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40314", "l": "hexanoyl-CoA + O2 <=> (2E)-hexenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68515", "l": "(2Z,6Z)-farnesyl diphosphate <=> alpha-acoradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50823", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) <=> H(+) + NADPH + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13411", "l": "7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH => 7-aminomethyl-7-carbaguanine + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66280", "l": "solanidine + UDP-alpha-D-glucose = H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19145", "l": "D-glucose 6-sulfate + H2O = D-glucose + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.3", "l": "\"glycosulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199112", "l": "CRTAM binds to NECL2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604763", "l": "Autocatalytic activation of MMP7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60824", "l": "H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate = 2 AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24469", "l": "H(+) + N,N-dimethylaniline + NADPH + O2 => H2O + N,N-dimethylaniline N-oxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419428", "l": "S1PR2-5 bind S1P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11035", "l": "(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate <=> 3-chloro-cis,cis-muconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74620", "l": "CMP(in) + UMP(out) => CMP(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611721", "l": "β1-agonists bind ADRB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372855", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474210", "l": "Collagen type III degradation by MMP14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0001681", "l": "sialate O-acetylesterase activity", "d": ["Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018459", "l": "carveol dehydrogenase activity", "d": ["Catalysis of the reaction: (1S,5R)-carveol + NADP+ = (R)-carvone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51044", "l": "indole-3-pyruvate imine dimer = CO2 + NH4(+) + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018499", "l": "cis-2,3-dihydrodiol DDT dehydrogenase activity", "d": ["Catalysis of the reaction: cis-2,3-dihydrodiol DDT + NADP+ = NADPH + 2,3-dihydroxy DDT."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509838", "l": "ITPA hydrolyses dITP to dIMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24909", "l": "L-tyrosine <=> (E)-4-coumarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47227", "l": "dehydroepiandrosterone 3-sulfate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxydehydroepiandrosterone 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46245", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42137", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41817", "l": "ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GD2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31855", "l": "(S)-2,3-epoxysqualene = achilleol B", "d": []}, {"i": "EC:5.4.99.48", "l": "\"achilleol B synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62418", "l": "4-hydroxybenzaldehyde + acetyl-CoA => (E)-4-coumaroyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n6", "l": "\"hexahomomethionine N-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75674", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate <=> 14,15-epoxy-12-hydroxy-(10E,17Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74984", "l": "(3R)-3-isocyanylbutanoyl-AMP + holo-[ACP] => (3R)-3-isocyanylbutanoyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876868", "l": "ECE1 cleaves EDN1(53-90) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381727", "l": "RAP1A exchanges GDP for GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672961", "l": "PP2A dephosphorylates inactive RAFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018543", "l": "4-amino-2-nitroso-6-nitrotoluene reductase activity", "d": ["Catalysis of the reaction: 4-amino-2-hydroxylamino-6-nitrotoluene + NADP+ = NADPH + H+ + 4-amino-2-nitroso-6-nitrotoluene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23293", "l": "ATP + L-lombricine => ADP + H(+) + N-phospho-L-lombricine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176298", "l": "Activation of claspin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030781", "l": "6-O-methylnorlaudanosoline 5'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69774", "l": "a short-chain fatty aldehyde + H2O + NAD(+) <=> a short-chain fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60697", "l": "(R)-lavandulyl diphosphate + H2O => (R)-lavandulol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83650", "l": "FasL:Fas binds FADD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611852", "l": "ADRB3 bind ADR,NAd (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613498", "l": "Unwinding of DNA for the nascent HIV-1 transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35928", "l": "paromamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin C + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3229181", "l": "CALM1:Ca2+ binds CNG channel (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37359", "l": "D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] = D-glucosamine 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031698", "l": "beta-2 adrenergic receptor binding", "d": ["Binding to a beta-2 adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851919", "l": "Activated MET binds GAB1 and GRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201685", "l": "Beta-catenin is released from the destruction complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59871", "l": "4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine <=> 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198756", "l": "ERK1/2 phosphorylates MSK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37485", "l": "1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29461", "l": "beta-alanine(out) + H(+)(out) => beta-alanine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.358", "l": "\"2-dehydropantolactone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29111", "l": "H(+) + NADPH + ubiquinone-8 = NADP(+) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60906", "l": "13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038200", "l": "ethylene receptor histidine kinase activity", "d": ["Combining with ethylene and transmitting the signal within the cell to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54163", "l": "2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2 <=> [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549304", "l": "OCT3 mediates renal clearance of organic cations (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75523", "l": "acetyl-CoA + S-methyl-L-cysteine = CoA + H(+) + N-acetyl-S-methyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801675", "l": "PLK2 phosphorylates NPM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141341", "l": "SMOX-3 oxidises SPN to SPM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32857", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53688", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043756", "l": "adenosylcobinamide hydrolase activity", "d": ["Catalysis of the reaction: adenosylcobinamide + H2O = (R)-1-aminopropan-2-ol + adenosylcobyrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2106625", "l": "Duplex siRNA is loaded into Argonaute (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033917", "l": "exo-poly-alpha-galacturonosidase activity", "d": ["Catalysis of the hydrolysis of pectic acid from the non-reducing end, releasing digalacturonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45023", "l": "L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29184", "l": "menaquinol-8 + 2 O2 => 2 H(+) + menaquinone-8 + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31548", "l": "2 (2E,6E)-farnesyl diphosphate => 15-cis-4,4'-diapophytoene + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77077", "l": "Capping complex formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080002", "l": "UDP-glucose:4-aminobenzoate acylglucosyltransferase activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + UDP-glucose = p-aminobenzoate-beta-D-glucopyranosyl ester + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014129", "l": "HEY1 gene expression is positively regulated by NOTCH3 and STAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12377", "l": "ATP + L-fuculose => ADP + H(+) + L-fuculose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097158", "l": "pre-mRNA intronic pyrimidine-rich binding", "d": ["Binding to a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0031776", "l": "melanin-concentrating hormone receptor binding", "d": ["Binding to a melanin-concentrating hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018594", "l": "MECP2 binds LBR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32782", "l": "ATP + Co(2+)(out) + H2O <=> ADP + Co(2+)(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-981713", "l": "C4b binds to cell surface (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26202", "l": "ammeline + H(+) + H2O => ammelide + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936380", "l": "Interaction of PIN1 with p-IRF3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22071", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) <=> (2S)-2-acetolactate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709317", "l": "CO binds to free ferrohemoglobin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72193", "l": "(16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900743", "l": "NOTCH1 HD+PEST domain mutants bind JAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20122", "l": "ATP + L-glutamine + tRNA(Gln) => AMP + diphosphate + L-glutaminyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55238", "l": "(9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047147", "l": "trimethylsulfonium-tetrahydrofolate N-methyltransferase activity", "d": ["Catalysis of the reaction: (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944397", "l": "p-T69,T71-ATF2 binds PTEN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11466", "l": "glutathione disulfide + 2 L-homocysteine => 2 glutathione + L,L-homocystine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848023", "l": "Activated PTK6 binds STAP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690414", "l": "SRY and NR5A1 (SF1) bind SOX9 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44235", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62076", "l": "D-galactose 6-phosphate + NAD(+) = 6-phospho-D-galactono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21988", "l": "malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside = 4'''-demalonylsalvianin + CoA", "d": []}, {"i": "EC:2.3.1.172", "l": "\"anthocyanin 5-O-glucoside 6'''-O-malonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005171", "l": "hepatocyte growth factor receptor binding", "d": ["Binding to an hepatocyte growth factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72529", "l": "1,6-dimethoxyphenazine + H(+) + S-adenosyl-L-homocysteine => 1-hydroxy-6-methoxyphenazine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380216", "l": "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450494", "l": "HuR binds mRNAs in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41940", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate = [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.43", "l": "\"[amino-group carrier protein]--L-2-aminoadipate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873923", "l": "STARD10 binds LPCAT1 and PC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60037", "l": "H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate => 3-hydroxy-3-methylhexanoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77608", "l": "Binding of A1CF to stem-looped RNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69142", "l": "Recruitment of Dna2 endonuclease (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72187", "l": "H(+)(out) + sucrose(out) = H(+)(in) + sucrose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21284", "l": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11867", "l": "H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine <=> dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46243", "l": "a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67996", "l": "(Z)-1,2-dichloroethene + AH2 = A + chloride + chloroethene + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52771", "l": "2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O <=> 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31745", "l": "a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine => a 4'-hydroxyflavanone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445699", "l": "ATP Hydrolysis By Myosin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64605", "l": "L-seryl-[protein] + UTP => diphosphate + uridylyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72948", "l": "acetate(out) + 2 Na(+)(out) => acetate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41232", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420977", "l": "Ca permeable AMPA receptor ligand binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41394", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+) => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202510", "l": "Activation of TAK1-TAB2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57953", "l": "H(+) + NADH + O2 + phenol => catechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466764", "l": "NRPE condenses with atRAL to form A2PE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102434", "l": "pterin-4alpha-carbinolamine dehydratase activity", "d": ["Catalysis of the reaction: a 10-formyltetrahydrofolate-4a-carbinolamine = H2O + a 10-formyldihydrofolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114254", "l": "CYCS binds to APAF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19106", "l": "4-aminobutanal + H2O + NAD(+) => 4-aminobutanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18189", "l": "[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)", "d": []}, {"i": "EC:2.4.1.21", "l": "\"starch synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28153", "l": "acetyl-CoA + spermidine <=> CoA + H(+) + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53717", "l": "H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP => phosphate + UDP-N-acetyl-alpha-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452701", "l": "Expression of DPPA4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74126", "l": "pelargonidin + UDP-alpha-D-galactose <=> pelargonidin 3-O-beta-D-galactoside betaine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40079", "l": "docosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32711", "l": "a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.n12", "l": "\"(3R)-hydroxyacyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "44.515291666518245", "identifiers": [{"i": "GO:0004930", "l": "G protein-coupled receptor activity", "d": ["Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20006", "l": "an alpha-D-glucuronoside + H2O => an alcohol + D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72671", "l": "eIF5B:GTP is hydrolyzed and released (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56752", "l": "a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.36", "l": "\"sterol 14alpha-demethylase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53124", "l": "all-trans-lycopene = delta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418553", "l": "cAMP degradation by Phosphodiesterases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696271", "l": "RND1 binds effectors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9794523", "l": "SLC22A1 transports Cipro into renal cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34946", "l": "hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) <=> arbutin 6-phosphate(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205231", "l": "Dimerization of KIT upon SCF binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042974", "l": "nuclear retinoic acid receptor binding", "d": ["Binding to a nuclear retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16501", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol = H(+) + myo-inositol + sn-glycerol 3-phosphate", "d": []}, {"i": "EC:3.1.4.44", "l": "\"glycerophosphoinositol glycerophosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58331", "l": "(Z)-non-6-en-1-ol + NADP(+) <=> (Z)-non-6-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799097", "l": "ATM phosphorylates ZNF420 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0031779", "l": "melanocortin receptor binding", "d": ["Binding to a melanocortin receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050340", "l": "thymidylate 5'-phosphatase activity", "d": ["Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018814", "l": "RHOT1 hydrolyzes GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13618", "l": "H2O + S-methyl-5'-thioadenosine => 5-(methylsulfanyl)-D-ribose + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418200", "l": "SRC-1 bound to ARRB2 is not activated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39595", "l": "(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH = (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.209", "l": "\"3(or 17)alpha-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180725", "l": "Rev associates with B23 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37755", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68645", "l": "(2E)-geranyl diphosphate => alpha-thujene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4717521", "l": "PIAS1 SUMOylates NR2C1 (TR2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59294", "l": "D-galactose + N-octadecanoylsphing-4-enine => beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008733", "l": "L-arabinose isomerase activity", "d": ["Catalysis of the reaction: L-arabinose = L-ribulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190245", "l": "FGFR1b binds to FGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849878", "l": "PSD-95 binds NMDA receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39222", "l": "3-oxooctacosanyol-CoA + H(+) + NADPH <=> (3R)-hydroxyoctacosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17315", "l": "AMP + diphosphate + H(+) + L-histidyl-tRNA(His) => ATP + L-histidine + tRNA(His)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033019", "l": "5-hydroxyvalerate dehydrogenase activity", "d": ["Catalysis of the reaction: 5-hydroxyvalerate + NAD+ = 5-oxovalerate + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757954", "l": "N4BP1 binds IKBKG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33815", "l": "CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate = 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.44", "l": "\"teichoic acid glycerol-phosphate primase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901973", "l": "proline binding", "d": ["Binding to proline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41802", "l": "3-oxobutanoyl-[ACP] + CO2 + holo-[ACP] => acetyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15672", "l": "a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP <=> a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098603", "l": "selenol Se-methyltransferase activity", "d": ["Catalysis of the reaction: R + Se-Adenosylselenomethionine => CH3-R + Se-Adenosyl-L-selenohomocysteine."]}, {"i": "REACT:R-HSA-2408544", "l": "AdoSeMet is converted to AdeSeHCys by MetTrans(1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57545", "l": "(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070967", "l": "coenzyme F420 binding", "d": ["Binding to F420, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981926", "l": "RAC1 and CDC42 activate PAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3899291", "l": "SUMOylation of EP300 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69593", "l": "CMP + inosine => cytidine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38017", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol => delta-tocotrienol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48737", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170986", "l": "Ral-GDS binds to Ras-GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.5", "l": "\"deoxyribonuclease X\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018746", "l": "RHOQ binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14740", "l": "CTP <=> 3',5'-cyclic CMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390886", "l": "HRH4 binds Hist (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21131", "l": "S-adenosyl-L-methionine + zymosterol <=> fecosterol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23843", "l": "3-(2,3-dihydroxyphenyl)propanoate + O2 <=> (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70601", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA => a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29424", "l": "ATP + diphosphate => ADP + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62745", "l": "H2O + mevastatin => (S)-2-methylbutanoate + compactin diol lactone + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18144", "l": "NAD(+) + trans-cyclohexane-1,2-diol <=> 2-hydroxycyclohexan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018804", "l": "RAC3 GEFs activate RAC3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044587", "l": "cellopentaose binding", "d": ["Binding to a cellopentaose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17793", "l": "H2O + L-alanyl-tRNA(Thr) = H(+) + L-alanine + tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29661", "l": "O-acetyl-L-serine(out) => O-acetyl-L-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201634", "l": "Caspase-mediated cleavage of FADK 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34085", "l": "a (3S)-3-hydroxyacyl-CoA => a (3R)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50016", "l": "H2O + octanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40305", "l": "(2E)-dodecenedioyl-CoA + AH2 => A + dodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16374", "l": "(R)-pantothenate + ATP => (R)-4'-phosphopantothenate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875591", "l": "DOCK7 activates RAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0034387", "l": "4-aminobutyrate:pyruvate transaminase activity", "d": ["Catalysis of the reaction: 4-aminobutanoate + pyruvate = succinate semialdehyde + alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28579", "l": "Co(2+)(in) => Co(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10975", "l": "D-hexose + H(+) + phosphoramidate <=> alpha-D-hexose 1-phosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033978", "l": "phosphonopyruvate hydrolase activity", "d": ["Catalysis of the reaction: 3-phosphonopyruvate + H2O = phosphate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865276", "l": "PDGF-AB clevage by Furin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24113", "l": "2 glutathione + O2 => glutathione disulfide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013108", "l": "GDIs block activation of RHOC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23961", "l": "H(+) + 2 H2O2 + hexadecanoate => CO2 + 3 H2O + pentadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70167", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203774", "l": "Interaction of Csk with PAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35192", "l": "noranthrone + O2 => H2O + norsolorinic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30912", "l": "a sphingomyelin + H2O => a carboxylate + sphing-4-enine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39818", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate <=> (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204824", "l": "Interaction of Tie2 and Ang4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40448", "l": "(2R)-pristanoyl-CoA => (2S)-pristanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38141", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47290", "l": "7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56668", "l": "7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.116", "l": "\"7beta-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047499", "l": "calcium-independent phospholipase A2 activity", "d": ["Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+."]}, {"i": "REACT:R-HSA-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.48", "l": "\"ceramide phosphoethanolamine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193661", "l": "PRDM4 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434637", "l": "PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74621", "l": "CMP(out) + UMP(in) => CMP(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169394", "l": "ISGylation of IRF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23050", "l": "(R)-2-hydroxyglutarate + acetoacetate => (S)-3-hydroxybutanoate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070324", "l": "thyroid hormone binding", "d": ["Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33234", "l": "H2O2 + heme b <=> heme d cis-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45777", "l": "(indol-3-yl)acetonitrile + 2 H2O => (indol-3-yl)acetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64341", "l": "(2E,6E)-farnesyl diphosphate + 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one => 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47485", "l": "deoxycholate + NAD(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52289", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209231", "l": "DOME:HOP complex forms a dimer at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75307", "l": "D-serine(in) + L-glutamine(out) + Na(+)(out) = D-serine(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2197770", "l": "STAB1 (FEEL-1) binds ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70573", "l": "argininosuccinate <=> fumarate + arginine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019969", "l": "interleukin-10 binding", "d": ["Binding to interleukin-10."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30393", "l": "2-oxoglutaramate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50626", "l": "a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+) => acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33250", "l": "O2 + putrescine <=> 1-pyrroline + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34472", "l": "NAD(+) + propanoyl-CoA => acryloyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42409", "l": "(2R)-2-phosphoglycerate + ATP => (2R)-2,3-bisphosphoglycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23576", "l": "(R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] = berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.66", "l": "\"berbamunine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18972", "l": "a long-chain fatty acid + H(+) + hnu <=> a long-chain alkane + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27450", "l": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193669", "l": "TRAF6 binds to p75NTR:NRIF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16342", "l": "(R)-5-phosphomevalonate + ATP => (R)-5-diphosphomevalonate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46583", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 <=> 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209891", "l": "Dopamine is oxidised to noradrenaline (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797090", "l": "CCNK binds CDK12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64961", "l": "dTDP + H2O => dTMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38281", "l": "(3R)-citramalyl-CoA + succinate => (3R)-citramalate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000399", "l": "RANBP2 SUMOylates SP100 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938217", "l": "RUNX1 binds the SWI/SNF complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44318", "l": "dodecanoate + glycerol + H(+) => 1-dodecanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25566", "l": "acetate + H(+) + N-acetylneuraminate => H2O + N-acetyl-4-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781840", "l": "ERCC6 binds stalled RNA Pol II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.28", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47013", "l": "[DsrC protein]-disulfide + H(+) + hydrogen sulfide => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12879", "l": "acetate + H(+) + methylglyoxal => acetylacetone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28011", "l": "propanoyl-CoA + succinate => propanoate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36917", "l": "3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA => (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69796", "l": "D-aspartyl-tRNA(Asp) + H2O => D-aspartate + H(+) + tRNA(Asp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53186", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16791", "l": "a 2-oxocarboxylate + H2O2 => a (2S)-2-hydroxycarboxylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717205", "l": "GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001857", "l": "complement component C1q receptor activity", "d": ["Combining with the C1q complex, a component of the classical complement cascade, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010429", "l": "methyl-CpNpN binding", "d": ["Binding to a methylated cytosine/unspecified/unspecified trinucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388833", "l": "Phosphorylation of CTLA-4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10005", "l": "benzyl isothiocyanate => benzyl thiocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71958", "l": "glutarate(out) + 3 Na(+)(out) <=> glutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73536", "l": "CDP(out) + UTP(in) => CDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940100", "l": "CDK1 phosphorylates VCPIP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690493", "l": "RHOB binds effectors on endosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47747", "l": "demethylphylloquinone + H(+) + NADPH <=> demethylphylloquinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857345", "l": "Activated CEBPB binds CDKN2B promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19277", "l": "ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)", "d": []}, {"i": "EC:6.1.1.26", "l": "\"pyrrolysine--tRNA(Pyl) ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358789", "l": "Self-ubiquitination of RNF41 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54814", "l": "AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate => (+)-7-isojasmonate + ATP + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27576", "l": "(3R)-piperidine-3-carboxylate + NH4(+) => (3R)-piperidine-3-carboxamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55001", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52318", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27537", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (3R,6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805740", "l": "SETD8 methylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689085", "l": "ATXN3 binds polyUb-PARK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53514", "l": "(13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate => (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68208", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol = 1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656219", "l": "Defective SLC4A4 does not cotransport Na+ with 3HCO3- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75128", "l": "neopinone => codeinone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0030515", "l": "snoRNA binding", "d": ["Binding to a small nucleolar RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799815", "l": "TP53 family members bind the FAS gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848436", "l": "PTK6 phosphorylates CDKN1B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49723", "l": "2 H(+) + NADH + 2 O2 + protoviolaceinate <=> CO2 + 2 H2O + NAD(+) + violacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67102", "l": "fumigatonoid C => fumigatonoid B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60023", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquisabinene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19572", "l": "5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59866", "l": "(indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+) => (indol-3-yl)butanoate + ATP + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66641", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + koraiol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0004774", "l": "succinate-CoA ligase activity", "d": ["Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-874084", "l": "IPAF is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26419", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 => (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18454", "l": "[(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O => [(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.108", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181355", "l": "Phosphorylation of R-SMAD2/3 by NODAL receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59636", "l": "D-xylotriose + O2 = D-xylotriono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665989", "l": "DIAPH1 binds RHOA:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57279", "l": "a 2'-deoxyguanosine in DNA + glyoxal <=> an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004913", "l": "interleukin-4 receptor activity", "d": ["Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482770", "l": "Release of platelet secretory granule components (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734475", "l": "PPARA binds fibrates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0038199", "l": "ethylene receptor activity", "d": ["Combining with ethylene and transmitting the signal in the cell to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59062", "l": "(20S)-ginsenoside Rh2 + D-glucose => (20S)-ginsenoside Rg3 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791109", "l": "GADD45A binds PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14267", "l": "5-aminolevulinate => (S)-4-amino-5-oxopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64282", "l": "acetophenone + L-alanine => (S)-1-phenylethylamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034610", "l": "oligodeoxyribonucleotidase activity", "d": ["Catalysis of the exonucleolytic cleavage of oligodeoxyribonucleotides to yield deoxyribonucleoside 5'-phosphates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69116", "l": "Formation of Okazaki fragments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671872", "l": "Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-741411", "l": "CYLD deubiquitinates NEMO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73921", "l": "H2O + norlichexanthone => 2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47608", "l": "3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22449", "l": "ATP + pseudouridine => ADP + H(+) + psi-UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22284", "l": "2 H(+) + H2O + N-carbamoylputrescine = CO2 + NH4(+) + putrescine", "d": []}, {"i": "EC:3.5.1.53", "l": "\"N-carbamoylputrescine amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18212", "l": "(2E)-geranyl diphosphate <=> (2S,4R)-bornyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805640", "l": "AKT phosphorylates KAT6A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981355", "l": "RASA1 binds RAS:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0098809", "l": "nitrite reductase activity", "d": ["Catalysis of the reaction: nitrite + acceptor = product(s) of nitrate reduction + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74716", "l": "Insulin binds the insulin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74713", "l": "5-dehydrofumagillol + H(+) + S-adenosyl-L-homocysteine => 5-dehydro-6-demethoxy-6-hydroxyfumagillol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37520", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780958", "l": "SOD1:Zn2+ apoenzyme binds CCS:Cu1+ (mitochondrial) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53592", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + H2O = 1-tetradecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696482", "l": "CTF1 binds LIFR:JAKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42693", "l": "[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate => [(1->4)-alpha-D-glucosyl](n+2) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40179", "l": "decanoyl-CoA + O2 = (2E)-decenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47667", "l": "H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) <=> 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878237", "l": "RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26013", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) <=> 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218832", "l": "CDC42:GTP binds PAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34081", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801101", "l": "RABGGTA binds RABGGTB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30688", "l": "(4R)-4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71107", "l": "L-leucine(out) + S-methylmercury-L-cysteine(in) = L-leucine(in) + S-methylmercury-L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.16", "l": "\"Xaa-Trp aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17916", "l": "H2O + NAD(+) + nitrite <=> H(+) + NADH + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42140", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-(4R)-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61480", "l": "a sphingoid base + a very long-chain fatty acyl-CoA = an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.297", "l": "\"very-long-chain ceramide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3364014", "l": "Recruitment of SET1 methyltransferase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1964496", "l": "STING binds TRIM32 or TRIM56  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876472", "l": "NPC2 binds CHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74411", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73104", "l": "diosmetin + S-adenosyl-L-methionine => luteolin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31992", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + sesquithujene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004137", "l": "deoxycytidine kinase activity", "d": ["Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12296", "l": "deacetylipecoside + H2O = dopamine + secologanin", "d": []}, {"i": "EC:4.3.3.4", "l": "\"deacetylipecoside synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48139", "l": "ganglioside GM3 + H2O <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637806", "l": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042500", "l": "aspartic endopeptidase activity, intramembrane cleaving", "d": ["Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975879", "l": "Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3318415", "l": "ATF2 acetylates histone H2B, H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59916", "l": "(2E)-octenal + H2O + NADP(+) = (2E)-octenoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034892", "l": "endosulfan lactone lactonase activity", "d": ["Catalysis of the reaction: endosulfan lactone + H2O = endosulfan hydroxycarboxylate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66767", "l": "ATP + folate(in) + H2O <=> ADP + folate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199576", "l": "KIR3DL2 interacting with HLA-A3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25673", "l": "sucrose + UDP-alpha-D-galactose <=> H(+) + loliose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40327", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20082", "l": "H2O + N-methylhexanamide => hexanoate + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54064", "l": "(2E,6E)-farnesyl diphosphate + H2O = 10-epi-cubebol + diphosphate", "d": []}, {"i": "EC:4.2.3.175", "l": "\"10-epi-cubebol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43564", "l": "4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine = [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate", "d": []}, {"i": "EC:2.6.1.108", "l": "\"(5-formylfuran-3-yl)methyl phosphate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29658", "l": "L-cysteine(in) <=> L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070866", "l": "sterol-dependent protein binding", "d": ["Binding to a protein or protein complex in the presence of sterols."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51718", "l": "AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39587", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814096", "l": "ARL1:GTP binds SCOC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663293", "l": "RORA, EP300 bind SREBF1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43156", "l": "guanosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.221", "l": "\"tRNA (guanine(9)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10664", "l": "NAD(+) + perillyl alcohol = H(+) + NADH + perillyl aldehyde", "d": []}, {"i": "EC:1.1.1.144", "l": "\"perillyl-alcohol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42514", "l": "5-aminopentanoate + acetate => 5-acetamidopentanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849797", "l": "Membrane proteases cleave Profilaggrin producing Filaggrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.59", "l": "\"protein geranylgeranyltransferase type I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140628", "l": "outward rectifier potassium channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of an outwardly rectifying potassium channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38749", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21512", "l": "3,6-anhydro-L-galactonate = 2-dehydro-3-deoxy-L-galactonate", "d": []}, {"i": "EC:5.5.1.25", "l": "\"3,6-anhydro-L-galactonate cycloisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18783", "l": "acetyl-CoA + CO2 => H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30139", "l": "H2O + octadecanoyl-CoA = CoA + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31911", "l": "beta-D-fructose 1,6-bisphosphate + methylglyoxal = 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63341", "l": "ATP + L-amino acyl-L-seryl-[protein] => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58210", "l": "AH2 + alstonine => A + dihydroalstonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70076", "l": "acetyl-CoA + AH2 + H(+) + 3 malonyl-CoA + 2 S-adenosyl-L-methionine => A + clavatol + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67815", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine <=> a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51089", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112435", "l": "Formation of Elongin BC complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803917", "l": "TP53 stimulates RGCC expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019788", "l": "NEDD8 transferase activity", "d": ["Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44751", "l": "5-amino-1-(beta-D-ribosyl)imidazole + ATP <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39209", "l": "(3R)-hydroxyhexacosanoyl-CoA + NADP(+) => 3-oxohexacosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20385", "l": "(2R,3R)-dihydroquercetin + H(+) + NADH + O2 = (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13845", "l": "dihydroxyfumarate + H(+) = 2-hydroxy-3-oxopropanoate + CO2", "d": []}, {"i": "EC:4.1.1.54", "l": "\"dihydroxyfumarate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42189", "l": "3beta-hydroxy-5alpha-androstan-17-one + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42448", "l": "(R)-2-hydroxyglutaryl-CoA = (2E)-glutaconyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.167", "l": "\"(R)-2-hydroxyglutaryl-CoA dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047274", "l": "galactinol-sucrose galactosyltransferase activity", "d": ["Catalysis of the reaction: sucrose + 1-alpha-D-galactosyl-myo-inositol = raffinose + myo-inositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71248", "l": "beta-alanine(out) + chloride(out) + 2 Na(+)(out) => beta-alanine(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202168", "l": "Phosphorylation of ZAP-70 by Lck (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65983", "l": "hnu + previtamin D3 <=> tachysterol 3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74059", "l": "beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000120", "l": "CBLIF binds RCbl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11504", "l": "6-demethylsterigmatocystin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + sterigmatocystin", "d": []}, {"i": "EC:2.1.1.109", "l": "\"demethylsterigmatocystin 6-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.88", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15555", "l": "1D-myo-inositol 4-phosphate + phosphate => 1D-myo-inositol 1,4-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59143", "l": "ATP + citrate + N(5)-[(S)-citryl]-D-ornithine <=> AMP + diphosphate + H(+) + staphyloferrin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27713", "l": "ATP + guanosine <=> ADP + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12203", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 <=> CO2 + mugineate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69413", "l": "2 glutathione + tert-butyl hydroperoxide => glutathione disulfide + H2O + tert-butanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669024", "l": "CD70 binds CD27 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68448", "l": "13-cis-lycopene + O2 = (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 13-cis-10'-apo-lycopenal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008499", "l": "UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380508", "l": "Translocation of NuMA to the centrosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24910", "l": "L,L-cystathionine = 2-aminobut-2-enoate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.49", "l": "\"separase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874685", "l": "CBL binds MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336443", "l": "LIN7, CASK and APBA1 bind (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0140838", "l": "RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) = RNA polymerase II large subunit trans-proline (omega=0)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864577", "l": "TFAP2C translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41218", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649108", "l": "HTR3A pentamer binds 5HT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.39", "l": "\"deuterolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800298", "l": "HGF dimer binds MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59499", "l": "(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] <=> (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47644", "l": "adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66695", "l": "dTDP-beta-L-rhamnose + L-arginyl-[protein] <=> dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18142", "l": "NAD(+) + trans-cyclohexane-1,2-diol => 2-hydroxycyclohexan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70233", "l": "(S)-2-benzoylsuccinyl-CoA + H(+) + NADH => (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50409", "l": "1-(2-aminophenyl)decane-1,3-dione => 2-heptyl-4(1H)-quinolone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001065", "l": "mitochondrial single subunit type RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type mitochondrial RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015382", "l": "sodium:sulfate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14703", "l": "CoA-disulfide + H(+) + NADH => 2 CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798372", "l": "ATM phosphorylates DYRK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987007", "l": "p-STAT1 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047936", "l": "glucose 1-dehydrogenase [NAD(P)] activity", "d": ["Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213244", "l": "Loading of antigenic peptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51390", "l": "CoA + H(+) + N-acetyl-dopamine => acetyl-CoA + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72873", "l": "anthocyanin A5 + CoA => anthocyanin A3 + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209355", "l": "Monomeric PGN binds to PGRP-LCx at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21807", "l": "ATP + myo-inositol <=> 1D-myo-inositol 3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306876", "l": "NLRP3 activation by small molecules (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.850581069382244", "identifiers": [{"i": "GO:0008410", "l": "CoA-transferase activity", "d": ["Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013143", "l": "RAC1 GEFs activate RAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856157", "l": "LAG3 (CD233) binds MHC II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59242", "l": "L-homoarginine + L-ornithine => L-arginine + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010396", "l": "SLIT1 binds COL4A5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40488", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111966", "l": "GRK2 binds CALM1:4Ca2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396029", "l": "Latent TGF-beta-3 binds integrins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61197", "l": "(E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37810", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41580", "l": "5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate = 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate", "d": []}, {"i": "EC:2.5.1.121", "l": "\"5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62490", "l": "2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15113", "l": "5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18810", "l": "L-alanine + oxomalonate => aminomalonate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5656070", "l": "FGFBPs bind FGFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70858", "l": "L-glutamine(out) + L-serine(in) + Na(+)(out) <=> L-glutamine(in) + L-serine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6790038", "l": "Expression of HSP90B1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0035035", "l": "histone acetyltransferase binding", "d": ["Binding to an histone acetyltransferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34242", "l": "L-glutamate <=> 3-aminopentanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47735", "l": "cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31201", "l": "(2E)-octenoyl-CoA + H2O => (3S)-hydroxyoctanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201630", "l": "Caspase-mediated cleavage of Acinus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40835", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O = 2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42675", "l": "gamma-L-glutamyl-L-cysteine + hercynine + O2 <=> gamma-L-glutamyl-hercynylcysteine S-oxide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40853", "l": "(2E)-pentadecenoyl-CoA + FADH2 => FAD + H(+) + pentadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047613", "l": "aconitate decarboxylase activity", "d": ["Catalysis of the reaction: cis-aconitate + H+ = CO2 + itaconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62750", "l": "(S)-2-methylbutanoate + H(+) + monacolin J => H2O + lovastatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68790", "l": "(Z)-gamma-bisabolene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23585", "l": "7,8-dihydropteroate + ATP + L-glutamate => 7,8-dihydrofolate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033881", "l": "bile-acid-CoA transferase activity", "d": ["Catalysis of the reaction: deoxycholoyl-CoA + cholate = deoxycholate + choloyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20253", "l": "(2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O", "d": []}, {"i": "EC:4.2.1.85", "l": "\"dimethylmaleate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46048", "l": "D-galactosamine 6-phosphate = alpha-D-galactosamine 1-phosphate", "d": []}, {"i": "EC:5.4.2.13", "l": "\"phosphogalactosamine mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75890", "l": "ADP-1-deoxy-1,O(4)-didehydro-D-ribose + L-arginyl-[protein] <=> ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53847", "l": "glycochenodeoxycholate + NAD(+) <=> 7-oxoglycolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24960", "l": "apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2 = [excited state blue fluorescent protein] + CO2", "d": []}, {"i": "EC:1.13.12.24", "l": "\"calcium-regulated photoprotein\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36325", "l": "(9Z)-octadecen-1-ol + CoA + 2 NADP(+) => (9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70062", "l": "a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3225867", "l": "Expression of MINK1/TNIK is positively regulated by ROS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694471", "l": "Polyadenylation of SARS-CoV-2 genomic RNA (plus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71028", "l": "L-glutamine(in) + L-phenylalanine(out) => L-glutamine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69447", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61569", "l": "an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48206", "l": "(2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17569", "l": "(R)-reticuline + NADP(+) = 1,2-dehydroreticuline + H(+) + NADPH", "d": []}, {"i": "EC:1.5.1.27", "l": "\"1,2-dehydroreticulinium reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951727", "l": "cAMP binds PKA tetramer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.5", "l": "\"Xaa-methyl-His dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72684", "l": "cholate(out) => cholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10355", "l": "an N-acetylarylalkylamine + H2O <=> acetate + an aralkylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36074", "l": "6-tuliposide A <=> D-glucose + tulipalin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52468", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12607", "l": "1-deoxy-D-xylulose 5-phosphate + CO2 => D-glyceraldehyde 3-phosphate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23737", "l": "5-hydroxyisourate + H2O => 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10844", "l": "oxaloacetate + pyridoxamine = L-aspartate + pyridoxal", "d": []}, {"i": "EC:2.6.1.31", "l": "\"pyridoxamine--oxaloacetate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48893", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O => L-threonyl-[protein] + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72182", "l": "2 Na(+)(out) + tauro-beta-muricholate(out) <=> 2 Na(+)(in) + tauro-beta-muricholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047180", "l": "salutaridinol 7-O-acetyltransferase activity", "d": ["Catalysis of the reaction: (7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031799", "l": "type 2 metabotropic glutamate receptor binding", "d": ["Binding to a type 2 metabotropic glutamate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25609", "l": "beta-D-allofuranose = beta-D-allopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22220", "l": "ent-copalyl diphosphate = diphosphate + ent-kaur-16-ene", "d": []}, {"i": "EC:4.2.3.19", "l": "\"ent-kaurene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210824", "l": "HNF6-dependent synthesis of HNF1B protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9669893", "l": "KIT binds type I TKIs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72328", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + vanillate => 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001918", "l": "farnesylated protein binding", "d": ["Binding to a farnesylated protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336182", "l": "GPR37 binds prosaptide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25165", "l": "A + butanoyl-CoA => (2E)-butenoyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0061603", "l": "molybdenum cofactor guanylyltransferase activity", "d": ["Catalysis of the reaction GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60354", "l": "CO + H(+) + N-octanoylanthranilate => 2-heptyl-3-hydroxy-4(1H)-quinolone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68916", "l": "ATP + butanoate + H(+) + NADPH = AMP + butanal + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604360", "l": "Initial activation of proMMP2 by MMP14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17814", "l": "D-altronate + NAD(+) => H(+) + keto-D-tagaturonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32328", "l": "10-hydroxy-alpha-humulene + NAD(+) => H(+) + NADH + zerumbone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45310", "l": "11beta-prostaglandin F2-ethanolamide + NADP(+) => H(+) + NADPH + prostaglandin D2-ethanolamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13079", "l": "a carboxylate + D-hexose phosphate + H(+) => an acyl phosphate + D-hexose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22492", "l": "H2O + N-formimidoyl-L-glutamate = formamide + L-glutamate", "d": []}, {"i": "EC:3.5.3.8", "l": "\"formimidoylglutamase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2562564", "l": "Caspase-8 processing within TLR4 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51309", "l": "H(+) + L-methionyl-[F-actin] + NADPH + O2 => H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13381", "l": "acetate + an acyl-CoA = a carboxylate + acetyl-CoA", "d": []}, {"i": "EC:2.8.3.8", "l": "\"acetate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5334827", "l": "SUMO-CRABP2 binds atRA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727886", "l": "SARS-CoV-1 SUMO-p-N binds to NPM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66016", "l": "bromide + H2O2 = H2O + hypobromite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67566", "l": "adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + chenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50962", "l": "H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74398", "l": "2 (S)-lactate(in) + prostaglandin E1(out) <=> 2 (S)-lactate(out) + prostaglandin E1(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730856", "l": "Autophosphorylation of PAK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23766", "l": "H(+) + O-phospho-L-serine + phosphate => diphosphate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724290", "l": "GNRHR2 binds GNRH1,2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19960", "l": "2 5'-dehydroinosine + O2 <=> 2 9-riburonosylhypoxanthine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008460", "l": "dTDP-glucose 4,6-dehydratase activity", "d": ["Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450063", "l": "Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36524", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA => (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050367", "l": "tyrosine-arginine ligase activity", "d": ["Catalysis of the reaction: L-arginine + L-tyrosine + ATP = L-tyrosyl-L-arginine + AMP + diphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018610", "l": "dibenzofuran 4,4a-dioxygenase activity", "d": ["Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014296", "l": "RAC2 GEFs activate RAC2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-481009", "l": "Exocytosis of platelet dense granule content (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42462", "l": "biphenyl-2,2',3-triol + NAD(+) => dibenzofuran + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106313", "l": "methylenetetrahydrofolate reductase NADPH activity", "d": ["Catalysis of the reaction: 5-methyltetrahydrofolate + NADP + = 5,10-methylenetetrahydrofolate + NADPH + H+."]}, {"i": "RHEA:19817", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32441", "l": "albaflavenone + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => (+)-epi-isozizaene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58007", "l": "(20S)-ginsenoside F2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rd + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791172", "l": "Expression of WIPI1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42314", "l": "NADPH + 2 oxidized [adrenodoxin] => H(+) + NADP(+) + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32409", "l": "(1R,4S)-isodihydrocarvone + H(+) + NADH => (1R,2S,4S)-neoisodihydrocarveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70971", "l": "citrate <=> isocitrate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.271", "l": "\"crocetin glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374337", "l": "Apelin receptor binds to apelin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11052", "l": "4-aminobenzoate + 2 H(+) + NADH + O2 = 4-aminophenol + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047416", "l": "arylalkyl acylamidase activity", "d": ["Catalysis of the reaction: H2O + N-acetylarylalkylamine = acetate + arylalkylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14190", "l": "D-tryptophan + O2 => N-formyl-D-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27447", "l": "D-xylose + H(+) + NADPH => NADP(+) + xylitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688025", "l": "Defective pro-SFTPB does not translocate from ER membrane to multivesicle body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68890", "l": "2-methoxybenzaldehyde + AMP + diphosphate + NADP(+) => 2-methoxybenzoate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-874087", "l": "SGT1 binds HSP90 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13611", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32256", "l": "meso-2,6-diaminoheptanedioate + NADP(+) => (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38062", "l": "2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA <=> 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11655", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose <=> alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46417", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22032", "l": "3-oxalomalate = glyoxylate + oxaloacetate", "d": []}, {"i": "EC:4.1.3.13", "l": "\"oxalomalate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13932", "l": "agmatine + H2O <=> putrescine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004852", "l": "uroporphyrinogen-III synthase activity", "d": ["Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665767", "l": "Activated FMNL3 binds G-actin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13322", "l": "(R)-3,3-dimethylmalate + NAD(+) => 3-methyl-2-oxobutanoate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047664", "l": "aminoimidazolase activity", "d": ["Catalysis of the reaction:4-aminoimidazole + H20 = imidazol-4-one + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40787", "l": "H2O + tetracosanoyl-CoA = CoA + H(+) + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51645", "l": "cholesterol + H(+) + NADH + O2 => 7-dehydrocholesterol + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34181", "l": "D-glucuronate + H(+) + mycophenolate => H2O + mycophenolic acid O-acyl-beta-D-glucuronide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433488", "l": "Phosphorylation of SHP2 by SFKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51939", "l": "2-(glutathione-S-yl)-hydroquinone + glutathione <=> glutathione disulfide + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62512", "l": "2-oxoglutarate + melatonin + O2 = 2-hydroxymelatonin + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10795", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.413456430472493", "identifiers": [{"i": "GO:0008238", "l": "exopeptidase activity", "d": ["Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950365", "l": "Expression of S-methyl-5'-thioadenosine phosphorylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17344", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) <=> 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35370", "l": "(2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH <=> isoheptadecanoyl-coA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54095", "l": "3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 <=> 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41009", "l": "6-linalyl-2-O,3-dimethylflaviolin + diphosphate => (2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211206", "l": "Translocation of DFF to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56790", "l": "cob(II)alamin-[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)alamin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5631885", "l": "PRDX1 overoxidizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072354", "l": "histone H3T3 kinase activity", "d": ["Catalysis of the reaction: histone H3-threonine (position 3) + ATP = histone H3-phosphothreonine (position 3) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 3 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20956", "l": "2-phenylacetate + ATP + CoA = AMP + diphosphate + phenylacetyl-CoA", "d": []}, {"i": "EC:6.2.1.30", "l": "\"phenylacetate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57965", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53674", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15548", "l": "(3S)-citramalate <=> acetate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18228", "l": "[N-(6-aminohexanoyl)](n) + H2O <=> 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18494", "l": "benzoyl-CoA + glycine => CoA + H(+) + N-benzoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42633", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.187403162058388", "identifiers": [{"i": "GO:0005342", "l": "organic acid transmembrane transporter activity", "d": ["Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548890", "l": "Removal of the third glucose by glucosidase II and release from the chaperone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51334", "l": "11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3341294", "l": "Superoxide reduces cytochrome c (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052816", "l": "long-chain acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: H2O + a long-chain acyl-CoA = a long-chain carboxylate + CoA. A long chain is a chain of greater than 12 carbons in length."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65580", "l": "H2O + TTP = H(+) + phosphate + TDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804276", "l": "ATM phosphorylates TTC5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55627", "l": "an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + H2O <=> 3-methylcytosine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13290", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109639", "l": "Formation of the closed pre-initiation complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61474", "l": "an N-hexadecanoyl-sphingoid base + CoA + H(+) => a sphingoid base + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72229", "l": "chloride(in) + 2 Na(+)(in) + sarcosine(in) => chloride(out) + 2 Na(+)(out) + sarcosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58527", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH <=> (16S)-deshydroxymethyl-stemmadenine + formate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21682", "l": "2-oxophytanate + H2O2 => (2S)-2-hydroxyphytanate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11339", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine <=> deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14391", "l": "an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20798", "l": "D-ribulose => aldehydo-D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69241", "l": "glucoraphanin + H2O => (Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73850", "l": "17alpha-hydroxywithaferin A + UDP-alpha-D-glucose <=> 17alpha-sitoindoside IX + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22596", "l": "cephalosporin C + H2O = acetate + deacetylcephalosporin C + H(+)", "d": []}, {"i": "EC:3.1.1.41", "l": "\"cephalosporin-C deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39589", "l": "(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+) => 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061708", "l": "tRNA-5-taurinomethyluridine 2-sulfurtransferase", "d": ["Catalysis of 5-taurinomethyluridine in tRNA + a [protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 5-taurinomethyl-2-thiouridine in tRNA + a [protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070736", "l": "protein-glycine ligase activity, initiating", "d": ["Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66651", "l": "(2E,6E)-farnesyl diphosphate <=> african-3-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72720", "l": "(R)-N(6)-dihydrolipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] => (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68369", "l": "3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose => 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40924", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41903", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] <=> 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451345", "l": "DSCAM binds DCC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16737", "l": "H(+) + NADH + O2 + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}, {"i": "EC:1.14.12.11", "l": "\"toluene dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60476", "l": "2 ATP + GTP = 3',3',3'-cAAG + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60875", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O <=> a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19036", "l": "an N-acyl-D-glucosamine <=> an N-acyl-D-mannosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22419", "l": "3,4-dihydroxybenzoate + H(+) <=> catechol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975857", "l": "TRAF6 binds to hp- IRAK1 or p-IRAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710254", "l": "GSDME oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75408", "l": "2-dehydro-D-glucose => cortalcerone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170846", "l": "TGFBR2 recruits TGFBR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419843", "l": "CALCA(83-119) binds CALCR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40897", "l": "(9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228525", "l": "RANBP2 SUMOylates TOP2A with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65118", "l": "aculene A + CO2 + H2O + succinate => 2-oxoglutarate + aculene B + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33110", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-muurolene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042924", "l": "neuromedin U binding", "d": ["Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67881", "l": "3'-phosphoadenylyl sulfate + dopamine => adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033834", "l": "kaempferol 3-O-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + kaempferol = UDP + kaempferol 3-O-beta-D-galactoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134953", "l": "DHX36 or DHX9 binds MyD88 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52806", "l": "(+)-eremophilene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58400", "l": "heptan-1-ol + NADP(+) = H(+) + heptanal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54536", "l": "a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727188", "l": "ATP4A:ATP4B binds PPIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350769", "l": "trans-Golgi Network Coat Activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51574", "l": "(25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858387", "l": "Activated STAT3 positively regulates CEBPB transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757256", "l": "MCM3 binds MCM5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64711", "l": "butan-1-ol + NADP(+) <=> butanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14194", "l": "3-hydroxybenzoate + AH2 + O2 => 2,3-dihydroxybenzoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11534", "l": "glyoxylate + H2O2 + NH4(+) => glycine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20631", "l": "L-seryl-[protein] + phosphate => H2O + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44782", "l": "H(+) + menaquinol-9 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-9 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177942", "l": "EGFR binds EGF ligand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44583", "l": "4-hydroxy-3-all-trans-decaprenylbenzoate + H(+) <=> 2-all-trans-decaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445087", "l": "CHL1 interacts with HSP7C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736992", "l": "p-2S-SMAD2,3:SMAD4 binds JUNB gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-535717", "l": "Binding of calnexin/calreticulin to the unfolded protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13275", "l": "6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13094", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71758", "l": "2-oxoglutarate(out) + 2-oxoheptanedioate(in) <=> 2-oxoglutarate(in) + 2-oxoheptanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29262", "l": "(2R,3R)-tartrate(out) + succinate(in) <=> (2R,3R)-tartrate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1461993", "l": "pro-HD5 is cleaved by trypsin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49332", "l": "2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59195", "l": "ATP + eicosanoate + H(+) <=> diphosphate + icosanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72621", "l": "Ribosomal scanning  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:1901236", "l": "4-(trimethylammonio)butanoate transmembrane transporter activity", "d": ["Enables the transfer of 4-(trimethylammonio)butanoate from one side of a membrane to the other."]}, {"i": "RHEA:32835", "l": "4-(trimethylamino)butanoate(in) = 4-(trimethylamino)butanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39947", "l": "1,3-diacyl-sn-glycerol + H2O = a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74975", "l": "a (3R)-3-isocyanyl-fatty acyl-AMP + holo-[ACP] = a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32300", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADH => 2 diphosphate + NAD(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55146", "l": "[4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH => [(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389756", "l": "AKT interacts and phosphorylates Cot (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604732", "l": "Autocatalytic activation of proMMP13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74233", "l": "L-threonine + tRNA(Val) => H2O + L-threonyl-tRNA(Val)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29095", "l": "5 H(+)(in) + NADH + ubiquinone-8 = 4 H(+)(out) + NAD(+) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390930", "l": "5-HT2 receptor can bind serotonin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.41", "l": "\"pullulanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062059", "l": "FACT complex binding", "d": ["Binding to a FACT complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54992", "l": "3 A + FMN + H2O + L-glutamate + O2 = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+)", "d": []}, {"i": "EC:2.6.1.114", "l": "\"8-demethyl-8-aminoriboflavin-5'-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60107", "l": "H(+) + indole-3-propanoate + oxidized [electron-transfer flavoprotein] <=> (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75175", "l": "dATP + NAD(+) = dADP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53433", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189062", "l": "lactose + H2O => D-glucose + D-galactose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72173", "l": "2 Na(+)(in) + taurohyocholate(in) => 2 Na(+)(out) + taurohyocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980074", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22429", "l": "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 => 2 H2O + isopenicillin N", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351341", "l": "Exocytosis of Proactivator polypeptide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088134", "l": "PLK1 phosphorylates FOXM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62740", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) = 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679101", "l": "Defective ABCG8 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58752", "l": "1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60518", "l": "D-tryptophan => L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75869", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => 5,6,7,8-tetrahydromethanopterin + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12922", "l": "glycine + H(+) + succinyl-CoA => 5-aminolevulinate + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685201", "l": "CCDC59:TTF1 binds SFTPC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449077", "l": "Interleukin-16 is secreted (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65402", "l": "butyl butanoate + CoA => butan-1-ol + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37139", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate = 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46864", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) = a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58970", "l": "1-naphthoate + H(+) + H2O2 => 1-naphthaldehyde + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680262", "l": "SARS coronavirus gRNA:RTC:RNA primer binds RTC inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626699", "l": "MARK4 binds ODF2 in the centriole (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63790", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480515", "l": "Expression of FGF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37980", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine => 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5228992", "l": "ROCK1,ROCK2 are activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042314", "l": "bacteriochlorophyll binding", "d": ["Binding to bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18634", "l": "2 ATP + H2O + hydrogencarbonate + L-glutamine => 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65473", "l": "2-methylbutanoyl-CoA + ethanol => CoA + ethyl 2-methylbutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40135", "l": "(9Z)-tetradecenoyl-CoA + H2O = (9Z)-tetradecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74704", "l": "(3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + O2 + reduced [NADPH--hemoprotein reductase] => 5-dehydro-6-demethoxyfumagillol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30414", "l": "benzoyl-CoA + benzyl alcohol <=> benzyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55295", "l": "pseudouridine(54) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52053", "l": "9-hexadecanoyloxy-octadecanoate + H2O => 9-hydroxy-octadecanoate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52532", "l": "adenosine + GTP = AMP + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008979", "l": "prophage integrase activity", "d": ["Catalysis of the integration of prophage DNA into a target DNA molecule, usually a bacterial chromosome, via a sequence-specific recombination event which involves the formation of an intasome, a DNA-protein-complex designed for site-specific recombination of the phage and host DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45164", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34002", "l": "zymosterol <=> 5alpha-cholesta-7,24-dien-3beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034634", "l": "glutathione transmembrane transporter activity", "d": ["Enables the transfer of glutathione, the tripeptide glutamylcysteinylglycine, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875816", "l": "STAT3 binds activated MET receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73976", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28892", "l": "H(+)(in) + putrescine(in) => H(+)(out) + putrescine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35274", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22846", "l": "glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25000", "l": "H(+) + N,N-dihydroxy-L-phenylalanine = (E)-phenylacetaldehyde oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.41", "l": "\"sterol 22-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938487", "l": "miR-20a binds RUNX1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40469", "l": "(9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+) => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68519", "l": "(2Z,6Z)-farnesyl diphosphate <=> beta-acoradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63641", "l": "(R)-N(6)-lipoyl-L-lysyl-[protein] + H2O + NAD(+) => 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29240", "l": "H(+)(in) + uracil(in) => H(+)(out) + uracil(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53902", "l": "ADP + H(+) + O-phospho-L-threonyl-[myosin light chain] => ATP + L-threonyl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70481", "l": "TPI1 isomerizes GA3P to DHAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19037", "l": "an epoxide + H2O = an ethanediol", "d": []}, {"i": "EC:3.3.2.10", "l": "\"soluble epoxide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018829", "l": "1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity", "d": ["Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane = HCl + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane is also known as DDD; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61555", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63424", "l": "(2S)-2-phospholactate + GTP + H(+) = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate", "d": []}, {"i": "EC:2.7.7.68", "l": "\"2-phospho-L-lactate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57555", "l": "[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] <=> (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60051", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 <=> a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70081", "l": "CO2 + hydroxyclavatol + succinate => 2-oxoglutarate + clavatol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867041", "l": "EGFR phosphorylates EPS15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70583", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052791", "l": "3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase activity", "d": ["Catalysis of the reaction: (2-keto-3-deoxynononic acid)n + H2O = (2-keto-3-deoxynononic acid)n-1 + 2-keto-3-deoxynononic acid. This reaction is the hydrolysis of a 2-keto-3-deoxynononic acid residue from a poly-2-keto-3-deoxynononic acid chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391935", "l": "DP1 receptor can bind PGD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45082", "l": "ADP + dapdiamide E + H(+) + phosphate => 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022869", "l": "protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + lactose(out) = protein histidine + lactose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22766", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668404", "l": "TNFA binds TNFR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36282", "l": "H(+) + NADH + O2 + theophylline <=> 3-methylxanthine + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60996", "l": "H2O + L-leucine + O2 = 4-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14115", "l": "a 3'-end 2'-deoxyribonucleotide-DNA + phosphate => a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938887", "l": "PML binds RUNX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52090", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61482", "l": "an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+) => a sphingoid base + a very long-chain fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53949", "l": "ATP + holo-[BtrI ACP] + L-glutamate => ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381727", "l": "RAP1A exchanges GDP for GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69101", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23819", "l": "2-oxoglutarate + putrescine <=> 4-aminobutanal + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33087", "l": "cyclic dehypoxanthinylfutalosinate = 1,4-dihydroxy-6-naphthoate + chemical entity", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53770", "l": "allocholoyl-CoA + allodeoxycholate => allocholate + allodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39842", "l": "a 2,3-diacyl-sn-glycerol + an acyl-CoA <=> a triacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23980", "l": "cyclomaltodextrin + H2O = linear maltodextrin", "d": []}, {"i": "EC:3.2.1.54", "l": "\"cyclomaltodextrinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36554", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol <=> 3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15252", "l": "3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose <=> 1-O-galloyl-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987007", "l": "p-STAT1 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67281", "l": "(2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione => (1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67038", "l": "(3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + CO2 + succinate => (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381668", "l": "cAMP activates EPAC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10550", "l": "4-guanidinobutanamide + CO2 + H2O => L-arginine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70294", "l": "3-(2-aminophenyl)-3-oxopropanal <=> H2O + quinolin-4-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205205", "l": "Interaction of Src family kinases with p-KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.12", "l": "\"dihydrobenzophenanthridine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956659", "l": "ABL1 phosphorylates YAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69116", "l": "Formation of Okazaki fragments (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981892", "l": "Active G alpha (z) binds RGS proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18327", "l": "(+)-amorpha-4,11-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420121", "l": "SFKs phosphorylate PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57968", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.170", "l": "\"8-epi-inunolide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434989", "l": "SEMA7A binds to PLXNC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213192", "l": "Hemidesmosome formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50984", "l": "prostaglandin E2(out) = prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49106", "l": "5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester => Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2562526", "l": "PLK1 phosphorylates OPTN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25392", "l": "(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) => cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71270", "l": "chloride(out) + L-pipecolate(out) + 2 Na(+)(out) <=> chloride(in) + L-pipecolate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61523", "l": "AH2 + dopamine <=> 3-tyramine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64705", "l": "diphenylmethanol + NAD(+) => benzophenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045508", "l": "interleukin-26 receptor activity", "d": ["Combining with interleukin-26 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.9", "l": "\"[Goodpasture-antigen-binding protein] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26038", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090582", "l": "protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-fructose(out) = protein cysteine + D-fructose-1-phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9702849", "l": "CALCR binds gepants (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67351", "l": "apigenin 7-O-beta-D-glucoside + malonyl-CoA <=> apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58536", "l": "glycine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16425", "l": "formaldehyde + H2O + NAD(+) = formate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.46", "l": "\"formaldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166538", "l": "The bound receptor dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082391", "l": "Trimerization of HSF1 in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168884", "l": "Hemagglutinin (HA) protein synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202203", "l": "Recruitment of PI3K to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20324", "l": "L-proline + NAD(+) <=> 1-pyrroline-2-carboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73166", "l": "FAD(out) + NAD(+)(in) <=> FAD(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870461", "l": "RABGGTA and RABGGTB bind (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31665", "l": "L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => 2-oxoglutarate + UDP-N-acetylbacillosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39303", "l": "(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA = (2E,11Z,14Z)-eicosatrienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67065", "l": "AH2 + asnovolin K => A + asnovolin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19586", "l": "lithocholate + NAD(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651828", "l": "PARG dePARylates PARP1,PARP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430311", "l": "Rsu-1 interacts with Pinch1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57171", "l": "(R)-2-hydroxyglutarate + FAD + H(+) <=> 2-oxoglutarate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032567", "l": "dGTP binding", "d": ["Binding to dGTP, deoxyguanosine triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427514", "l": "eNoSC deacetylates histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68344", "l": "ATP + GTP = 3',2'-cGAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0046976", "l": "histone H3K27 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group to the lysine residue at position 27 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23624", "l": "a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26387", "l": "(2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal => all-trans-8'-apo-beta-carotenal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "45.967661518826745", "identifiers": [{"i": "GO:0015267", "l": "channel activity", "d": ["Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72095", "l": "Internal Methylation of mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23870", "l": "acetyl-CoA + cyclohexanone => (1-hydroxycyclohexan-1-yl)acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183067", "l": "Localization of CBL:GRB2 to the membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65957", "l": "ATP + estrone 3-sulfate(out) + H2O => ADP + estrone 3-sulfate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68849", "l": "(2Z,6E)-farnesyl diphosphate => diphosphate + gamma-cadinene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944218", "l": "Association of procollagen type VIII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56593", "l": "a disubstituted aliphatic (S)-hydroxynitrile => a ketone + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5195402", "l": "CDK1 phosphorylates LPIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210788", "l": "HNF1B- and FGF10-dependent synthesis of PTF1A protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70649", "l": "D-serine(in) + H(+)(in) => D-serine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61492", "l": "a sphingoid base + an ultra-long-chain fatty acyl-CoA = an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.298", "l": "\"ultra-long-chain ceramide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4167511", "l": "HLCS biotinylates ACACB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24614", "l": "estrone + H(+) + NADH => 17beta-estradiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23221", "l": "4-chlorobenzoate + ATP + CoA => 4-chlorobenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419843", "l": "CALCA(83-119) binds CALCR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54943", "l": "(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28640", "l": "(2Z,6E)-farnesyl diphosphate => (-)-gamma-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40974", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39912", "l": "(2S,3S)-3-methylphenylalanine + 2-oxoglutarate => (3S)-2-oxo-3-phenylbutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047489", "l": "pectate disaccharide-lyase activity", "d": ["Catalysis of the reaction: a pectate = a pectate + 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate. This reaction is the eliminative cleavage of 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate from the reducing end of pectate, i.e. de-esterified pectin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48730", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH => 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44169", "l": "dodecanoate + 2 H(+) + NADH => dodecanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.-", "l": "\"Dipeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202111", "l": "AKT1 phosphorylates eNOS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700131", "l": "ALK mutants bind type I TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983696", "l": "The Immunoglobulin of the BCR binds antigen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418845", "l": "Activation of caspase-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647680", "l": "CASP1 cleaves GSDMD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797974", "l": "LRRTMs bind NRXNs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047779", "l": "citrate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + citrate + CoA = (3S)-citryl-CoA + ADP + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50045", "l": "an acyl-CoA + H2O => adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9633044", "l": "ESR binds STRN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696605", "l": "USP12, USP26 deubiquitinate AR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047908", "l": "fusarinine-C ornithinesterase activity", "d": ["Catalysis of the reaction: N5-acyl-L-ornithine ester + H2O = N5-acyl-L-ornithine + an alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985275", "l": "RUNX2 binds to SATB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10002", "l": "NH4(+) + pentanoate => H2O + pentanamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67867", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] <=> 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047142", "l": "enzyme-thiol transhydrogenase (glutathione-disulfide) activity", "d": ["Catalysis of the reaction: oxidized glutathione + [xanthine dehydrogenase] = reduced glutathione + xanthine-oxidase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45755", "l": "(3E)-decenoyl-CoA <=> (2E)-decenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69502", "l": "ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide => L-arginyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23844", "l": "ATP + sedoheptulose = ADP + D-sedoheptulose 7-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.14", "l": "\"sedoheptulokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40006", "l": "ent-copalyl diphosphate <=> (Z)-biformene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848338", "l": "PNPLA4 hydrolyzes TAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47376", "l": "(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801195", "l": "STEAP3 binds BNIP3L (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15450", "l": "homogentisate + O2 => 4-maleylacetoacetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797974", "l": "LRRTMs bind NRXNs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46566", "l": "acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+) => acetyl-CoA + apo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14605", "l": "D-glucose 6-phosphate + GDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.36", "l": "\"alpha,alpha-trehalose-phosphate synthase (GDP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19230", "l": "AMP + an aromatic aldehyde + diphosphate + NADP(+) => an aromatic carboxylate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14749", "l": "1-hydroxy-2-naphthoate + O2 = (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)", "d": []}, {"i": "EC:1.13.11.38", "l": "\"1-hydroxy-2-naphthoate 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50990", "l": "prostaglandin F2alpha(in) => prostaglandin F2alpha(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36499", "l": "2-dehydro-3-deoxy-L-rhamnonate + NAD(+) = 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.401", "l": "\"2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65643", "l": "(4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33923", "l": "(1R,4R)-5-oxo-1,2-campholide = [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37702", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641147", "l": "DACT1 binds DVL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625426", "l": "Retrograde IFT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080015", "l": "sabinene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = sabinene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102530", "l": "aclacinomycin T methylesterase activity", "d": ["Catalysis of the reaction: aclacinomycin T(1+) + H2O <=> 15-demethylaclacinomycin T + methanol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610408", "l": "GluN1:GluN2B (GRIN1:GRIN2B) di-heterotetramers bind LIN7:CASK:APBA1, DLG1 and KIF17 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805620", "l": "KAT6A and PML bind TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68595", "l": "ORC2 binds ORC3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14132", "l": "cholate + NADP(+) <=> 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610722", "l": "CK1 phosphorylates p-GLI3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.163", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696960", "l": "USP49 deubiquitinates H2B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901640", "l": "XTP binding", "d": ["Binding to XTP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19657", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) = CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34046", "l": "5-phospho-alpha-D-ribose 1-diphosphate + neamine <=> 5''-phosphoribostamycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10085", "l": "3,4-dihydroxybenzoate + O2 => 3-carboxy-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41746", "l": "a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052642", "l": "lysophosphatidic acid phosphatase activity", "d": ["Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol."]}, {"i": "REACT:R-HSA-8878654", "l": "ACP6 hydrolyses MYS-LPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17716", "l": "(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15229", "l": "alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-alpha-D-mannose", "d": []}, {"i": "EC:2.7.7.13", "l": "\"mannose-1-phosphate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434836", "l": "Syk/Lck phosphorylate LAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61334", "l": "ADP + H(+) + indoxyl sulfate(out) + phosphate => ATP + H2O + indoxyl sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73493", "l": "Co(2+)(in) + 2 hydrogencarbonate(in) => Co(2+)(out) + 2 hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53819", "l": "hydrogen sulfide + O-succinyl-L-serine <=> L-cysteine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374723", "l": "Nociceptin receptor binds to nociceptin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.21", "l": "\"dipeptidase E\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52914", "l": "3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O => 3-dimethylallyl-4-hydroxymandelate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53088", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2534365", "l": "Slo3 Potassium Transport (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140340", "l": "cerebroside transfer activity", "d": ["Directly binding to a cerebroside and delivering it either to an acceptor molecule or to a specific location."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964580", "l": "The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds CCNA2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66010", "l": "[collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O => (5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866277", "l": "AP-2 directly binds some endocytic cargo (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61160", "l": "quercetin + UDP-beta-L-rhamnose = H(+) + quercitrin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64720", "l": "H(+)(out) + pyruvate(out) = H(+)(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41832", "l": "(2E)-hexenoyl-[ACP] + H(+) + NADPH = hexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18628", "l": "D-galactose + NADP(+) <=> D-galactono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51122", "l": "(8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34225", "l": "2,6-dihydroxypseudooxynicotine + AH2 => 6-hydroxypseudooxynicotine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32667", "l": "coenzyme M + methanethiol = H(+) + hydrogen sulfide + methyl-coenzyme M", "d": []}, {"i": "EC:2.1.1.251", "l": "\"methylated-thiol--coenzyme M methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082356", "l": "HSF1-mediated gene expression (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60835", "l": "a 5'-end triphospho-guanosine in mRNA + H2O <=> a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29923", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.142", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34372", "l": "H2O + indole-3-acetamide => (indol-3-yl)acetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72359", "l": "glutarate(in) + succinate(out) = glutarate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691335", "l": "nsp7 binds nsp8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28735", "l": "H(+)(in) + spermidine(out) = H(+)(out) + spermidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45087", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37016", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10074", "l": "glycine betaine + H(+) + S-adenosyl-L-homocysteine => N,N-dimethylglycine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14555", "l": "2-oxoglutarate + cephalosporin C => (7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624494", "l": "RAF1 binds p21 RAS:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50195", "l": "L-seryl-[protein] + UDP-alpha-D-xylose <=> 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8870461", "l": "RABGGTA and RABGGTB bind (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36984", "l": "(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34477", "l": "15-cis-phytoene + 2 diphosphate => 2 (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46624", "l": "a D-5-monosubstituted hydantoin = a L-5-monosubstituted hydantoin", "d": []}, {"i": "EC:5.1.99.5", "l": "\"hydantoin racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22548", "l": "H2O + L-lysine + O2 = (S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)", "d": []}, {"i": "EC:1.4.3.20", "l": "\"L-lysine 6-oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69076", "l": "(R)-noradrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42427", "l": "2-methylmaleate + H2O <=> (2R,3S)-3-methylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.89", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40910", "l": "2 2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013435", "l": "RHOD auto-activates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.65", "l": "\"macrophage elastase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39604", "l": "(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA => (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46744", "l": "ATP + hydrogencarbonate = ADP + carboxyphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30095", "l": "(S)-malate + a menaquinone = a menaquinol + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-976768", "l": "Factor H binds to C3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008389", "l": "RUNX2 binds HDAC6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047075", "l": "2,5-dihydroxypyridine 5,6-dioxygenase activity", "d": ["Catalysis of the reaction: H2O + O2 + 2,5-dihydroxypyridine = formate + maleamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56122", "l": "3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-heptaprenylphenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045238", "l": "CXCR2 chemokine receptor binding", "d": ["Binding to a CXCR2 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649856", "l": "Oxidative damage to the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019162", "l": "pyridoxamine-oxaloacetate transaminase activity", "d": ["Catalysis of the reaction: oxaloacetate + pyridoxamine = L-aspartate + pyridoxal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73142", "l": "lithocholate(out) <=> lithocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669240", "l": "FLNA binds PAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735179", "l": "GATA4 and LEF1:CTNNB1 bind the ISL1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21323", "l": "A + D-sorbitol <=> AH2 + keto-L-sorbose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374673", "l": "L1 binds RanBPM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6802973", "l": "PLK3 phosphorylates CDC25C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190829", "l": "Lysosomal degradation of gap junction plaques (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40626", "l": "H2O + tritetradecanoylglycerol <=> 2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75121", "l": "all-trans-13,14-dihydroretinoate + 2 H(+) + NADH => all-trans-13,14-dihydroretinal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46910", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + a 1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0017050", "l": "D-erythro-sphingosine kinase activity", "d": ["Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420975", "l": "Ca impermeable AMPA receptor ligand binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23040", "l": "2-oxobutanoate + acetyl-CoA + H2O = (R)-2-ethylmalate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.6", "l": "\"2-ethylmalate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74216", "l": "H2O + L-seryl-tRNA(Lys) => L-serine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51782", "l": "deoxyadlupulone + diphosphate => 4-prenylphlormethylbutanophenone + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23526", "l": "an alkyl cinnamate + beta-D-glucose => 1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11556", "l": "(S)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.254", "l": "\"(S)-carnitine 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70907", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate = (2R)-3-phosphoglycerate + alpha-D-mannose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22035", "l": "3-oxalomalate <=> glyoxylate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38636", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2301205", "l": "SETD8 monomethylates histone H4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59652", "l": "D-xylotetraono-1,5-lactone + H2O = D-xylotetraonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25014", "l": "H(+) + N,N-dihydroxy-L-tryptophan => (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047748", "l": "cholestanetetraol 26-dehydrogenase activity", "d": ["Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19116", "l": "(8Z,11Z,14Z)-heptadecatrienal + A + H2O <=> (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59043", "l": "4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28148", "l": "3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029680", "l": "Caspase-7 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36931", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22259", "l": "a (3R)-3-hydroxyacyl-CoA + NADP(+) <=> a 3-oxoacyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11427", "l": "ATP + L-threonyl-[myosin heavy-chain] <=> ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24724", "l": "H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+) => H(+) + L-methionyl(44)-[F-actin] + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67821", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168376", "l": "STIM1 oligomerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23611", "l": "H(+) + H2O + N-isopropylammelide <=> cyanurate + isopropylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039630", "l": "RNA translocase activity", "d": ["Generating a movement along a single- or double-stranded RNA molecule, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12731", "l": "(3R,3'S)-zeaxanthin => lutein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42525", "l": "uridine(1911/1915/1917) in 23S rRNA => pseudouridine(1911/1915/1917) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67426", "l": "a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+) => a glycerophospholipid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29780", "l": "ATP + H2O + L-methionine(out) => ADP + H(+) + L-methionine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947531", "l": "Molybdenum ion transfer onto molybdopterin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004920", "l": "interleukin-10 receptor activity", "d": ["Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41355", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63502", "l": "NADP(+) + sulfinamide glutathione => H(+) + NADPH + S-nitrosoglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16292", "l": "(1R,2S)-ephedrine + NAD(+) <=> (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22267", "l": "3,5,6-trichloropyridin-2-ol + FADH2 + O2 <=> 3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733969", "l": "Bile salts dissociate from FABP6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39290", "l": "Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + trimethylamine <=> dimethylamine + methyl-Co(III)-[trimethylamine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297333", "l": "Association of Acrosin Heavy and Light Chain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6790038", "l": "Expression of HSP90B1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975156", "l": "IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204824", "l": "Interaction of Tie2 and Ang4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68486", "l": "CO2 + H2O + undecanal => (2R)-2-hydroperoxydodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51892", "l": "H2O + N-acetylcadaverine = acetate + cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67694", "l": "ADP + H(+) + hexadecanedioate(out) + phosphate => ATP + H2O + hexadecanedioate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34165", "l": "(2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+) => hydroquinone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60066", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+) => a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14500", "l": "A + pyridoxine <=> AH2 + isopyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61366", "l": "ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate => ATP + dehydroepiandrosterone 3-sulfate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.70", "l": "\"glucan 1,6-alpha-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39863", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12099", "l": "H2O + N-benzylformamide <=> benzylamine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46788", "l": "a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761852", "l": "NFE2L2-dependent TKT gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43395", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O <=> 1D-myo-inositol 1,3-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26336", "l": "2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O <=> 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75458", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56739", "l": "H2O + O2 + retinal <=> H(+) + H2O2 + retinoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391936", "l": "EP1 receptor can bind PGE2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430183", "l": "NCK binds PAK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52525", "l": "O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69053", "l": "RFC binding displaces Pol Alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63508", "l": "a 1,2-saturated fatty acid + O2 = a (2R)-2-hydroperoxy fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72955", "l": "2 Na(+)(out) + nicotinate(out) = 2 Na(+)(in) + nicotinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48619", "l": "H2O + leukotriene D4 <=> glycine + leukotriene E4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12539", "l": "H(+) + L-arogenate <=> CO2 + H2O + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44153", "l": "1D-myo-inositol 2-phosphate + H2O => myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659674", "l": "Variant SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65710", "l": "beta-L-galactose 1-phosphate + GDP-alpha-D-mannose => alpha-D-mannose 1-phosphate + GDP-beta-L-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-921155", "l": "p-STAT5 dissociates from the receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018614", "l": "ethylbenzene dioxygenase activity", "d": ["Catalysis of the reaction: ethylbenzene + O2 + NADH + H+ = NAD+ + cis-2,3-dihydroxy-2,3-dihydroethylbenzene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042609", "l": "CD4 receptor binding", "d": ["Binding to a CD4, a receptor found on the surface of T cells, monocytes and macrophages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45309", "l": "H(+) + NADPH + prostaglandin D2-ethanolamide => 11beta-prostaglandin F2-ethanolamide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58090", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+) => 1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.33", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0016625", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an iron-sulfur protein."]}, {"i": "EC:1.2.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985201", "l": "ABCE1 binds RNASEL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16432", "l": "ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6791109", "l": "GADD45A binds PCNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937613", "l": "CRHBP binds CRH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59251", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA <=> (E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69120", "l": "glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61449", "l": "H(+) + NADPH + O2 + tigecycline => 11a-hydroxytigecycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5334794", "l": "FABPs bind LCFAs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69511", "l": "H2O + N-acetyl-D-glucosamino-1,5-lactone <=> H(+) + N-acetyl-D-glucosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36760", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine => alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672083", "l": "KTN1 binds Kinesin-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381704", "l": "G(s):GTP activates Adenylyl cyclase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211191", "l": "Association of DFF with alpha:beta importin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11104", "l": "N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine = H(+) + hercynine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36555", "l": "eicosanoyl-CoA + sphinganine = CoA + H(+) + N-eicosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618331", "l": "HDAC6 deacetylates microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73470", "l": "beta-alanyl-dopamine + H2O <=> beta-alanine + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32414", "l": "(1R,2R,4S)-isodihydrocarveol + NAD(+) <=> (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75904", "l": "ADP-D-glycero-beta-D-manno-heptose + L-seryl-[protein] => ADP + H(+) + O-(D-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53866", "l": "7,12-dioxo-lithocholate + H(+) + NADPH => 3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5683774", "l": "p-T68-CHEK2 dimerizes (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11564", "l": "4-O-beta-D-glucopyranosyl-D-gluconate + phosphate = alpha-D-glucose 1-phosphate + D-gluconate", "d": []}, {"i": "EC:2.4.1.321", "l": "\"cellobionic acid phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785898", "l": "IL4R binds JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015346", "l": "ferric triacetylfusarinine C:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69140", "l": "RPA binds to the Flap (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878243", "l": "HES1 gene transcription is inhibited by RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70018", "l": "O2 + reduced [NADPH--hemoprotein reductase] + teasterone <=> 7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647680", "l": "CASP1 cleaves GSDMD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32200", "l": "androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390674", "l": "ADRB1 bind ADR,NAd (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004946", "l": "bombesin receptor activity", "d": ["Combining with bombesin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874079", "l": "PTK2 binds activated MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047532", "l": "2,5-dioxopiperazine hydrolase activity", "d": ["Catalysis of the reaction: 2,5-dioxopiperazine + H2O = glycylglycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611839", "l": "β3-agonists bind ADRB3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004667", "l": "prostaglandin-D synthase activity", "d": ["Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24504", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)", "d": []}, {"i": "EC:1.13.11.54", "l": "\"acireductone dioxygenase (Fe(2+)-requiring)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60060", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15169", "l": "H2O + N-succinyl-L-glutamate = L-glutamate + succinate", "d": []}, {"i": "EC:3.5.1.96", "l": "\"succinylglutamate desuccinylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67367", "l": "H2O + L-threonyl-L-serine <=> L-serine + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106237", "l": "arachidonate 12(R)-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12R,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate."]}, {"i": "RHEA:41336", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10058", "l": "(2E)-butenoyl-CoA + NH4(+) => (3S)-3-aminobutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71646", "l": "guanosine + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37318", "l": "glycyl-L-glutamine + H2O <=> glycine + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35385", "l": "CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine => precorrin-6B + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052609", "l": "4-ketotorulene 3-hydroxylase activity", "d": ["Catalysis of the reaction: 4-ketotorulene + a reduced electron acceptor + oxygen = 3-hydroxy-4-ketotorulene + an oxidized electron acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44658", "l": "a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.2.-", "l": "\"Phosphotransferases with a carboxy group as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22310", "l": "D-xylose + H2O2 => O2 + xylitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635918", "l": "Expression of CEBPB in response to stress (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862184", "l": "USP48 cleaves polyubiquitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671702", "l": "AP1G2 binds HGS and CHMP2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65242", "l": "(11Z)-octadecenoate + CoA + H(+) => (11Z)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12482", "l": "4,5-dioxopentanoate + L-alanine => 5-aminolevulinate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005151", "l": "interleukin-1, type II receptor binding", "d": ["Binding to a Type II interleukin-1 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72219", "l": "3 hydrogencarbonate(out) + Na(+)(out) = 3 hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005316", "l": "high-affinity inorganic phosphate:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56500", "l": "(R)-3,5-bisphosphomevalonate + H(+) = CO2 + isopentenyl phosphate + phosphate", "d": []}, {"i": "EC:4.1.1.110", "l": "\"bisphosphomevalonate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-500717", "l": "Activation of GRIK3 homomer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433454", "l": "Phosphorylation of GAB2 by SFKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46153", "l": "15-cis-phytoene + a plastoquinone => 15,9'-di-cis-phytofluene + a plastoquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296127", "l": "Activation of voltage gated Potassium channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708275", "l": "PDE4A binds PDE4A inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24899", "l": "2 GTP => 3',3'-c-di-GMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22704", "l": "2 H2O + ricinine = 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)", "d": []}, {"i": "EC:3.5.5.2", "l": "\"ricinine nitrilase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183051", "l": "CBL ubiquitinates Sprouty (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83791", "l": "Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50482", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68279", "l": "butanoyl-CoA + L-seryl-[protein] <=> CoA + O-butanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17976", "l": "diphosphate + IMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71605", "l": "2-oxoglutarate(in) + oxaloacetate(out) => 2-oxoglutarate(out) + oxaloacetate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106026", "l": "Gly-tRNA(Ala) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Gly-tRNA(Ala)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28829", "l": "L-ornithine(in) + putrescine(out) => L-ornithine(out) + putrescine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55926", "l": "albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => albendazole + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60604", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31197", "l": "3-oxooctanoyl-CoA + H(+) + NADH => (3S)-hydroxyoctanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65183", "l": "AH2 + O2 + protoaustinoid B <=> A + H2O + preaustinoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57380", "l": "(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.163", "l": "\"(S)-1-hydroxy-N-methylcanadine 13-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0031717", "l": "cannabinoid receptor binding", "d": ["Binding to a cannabinoid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20426", "l": "2-oxoglutarate + ATP + hydrogencarbonate => (S)-oxalosuccinate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37687", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21754", "l": "all-trans-capsorubin => all-trans-violaxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379977", "l": "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20110", "l": "alpha-D-ribose 1,5-bisphosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3244643", "l": "STING binds cyclic GMP-AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24734", "l": "2-oxoglutarate + 4-hydroxybutanoate = (R)-2-hydroxyglutarate + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33111", "l": "(2E,6E)-farnesyl diphosphate = beta-copaene + diphosphate", "d": []}, {"i": "EC:4.2.3.127", "l": "\"beta-copaene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53000", "l": "17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37113", "l": "CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine => (15Z)-tetracosenoyl-CoA + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38577", "l": "(9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134914", "l": "Beta-catenin migrates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388831", "l": "Phosphorylation of CD28 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61997", "l": "L-lysyl-[protein] + lactoyl-CoA => CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54645", "l": "trans-4-hydroxy-L-proline => (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756948", "l": "p-2S-SMAD2,3:SMAD4, p-2S-SMAD2,3:TRIM33, CTNNB1, EOMES, and TBPL2 bind FOXH1:SMAD3:GSC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59037", "l": "4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390673", "l": "CHRM2,4 bind acetylcholine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74501", "l": "H2O + NADP(+) + penigequinolone A => H(+) + NADPH + yaequinolone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22958", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12193", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69770", "l": "(E)-non-2-enal + H2O + NAD(+) <=> (E)-non-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20577", "l": "3-hydroxyaminophenol = aminohydroquinone", "d": []}, {"i": "EC:5.4.4.3", "l": "\"3-(hydroxyamino)phenol mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53602", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65141", "l": "AH2 + O2 + protoaustinoid A => A + berkeleyone A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353226", "l": "Association of Ku heterodimer with ends of DNA double-strand breaks (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163798", "l": "Furin cleaves pro-protein Z to protein Z (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40733", "l": "(20S)-protopanaxadiol + 2 D-glucose => (20S)-ginsenoside Rg3 + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093327", "l": "EPHA binds TIAM1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983424", "l": "Budding of COPII coated vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45810", "l": "(2S,3R)-dihydroxy-5-oxohexanedioate + H2O => galactarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56128", "l": "A + dimethylallyl diphosphate + H2O + nonaflavuxanthin = AH2 + diphosphate + flavuxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30816", "l": "beta-nicotinamide D-ribonucleotide + H2O => beta-nicotinamide D-riboside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73122", "l": "kaempferol + S-adenosyl-L-methionine <=> H(+) + kaempferol 7-methyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54575", "l": "a uridine in tRNA <=> a pseudouridine in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.426", "l": "\"UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010357", "l": "homogentisate solanesyltransferase activity", "d": ["Catalysis of the reaction: homogentisic acid + all-trans-nonaprenyl diphosphate + 3 H+ = 2-methyl-6-solanyl-1,4-benzoquinonone + CO2 + diphosphate. 2-methyl-6-solanyl-1,4-benzoquinonone is also known as 2-methyl-6-solanesylplastoquinol and all-trans-nonaprenyl diphosphate as solanesyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35543", "l": "3-phosphooxypyruvate + H2O = 3-hydroxypyruvate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11863", "l": "ATP + L-histidyl-[protein] <=> ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51332", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = 11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449058", "l": "Interleukin-1 family are secreted (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24400", "l": "ATP + UMP = ADP + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13752", "l": "a ribonucleoside 5'-triphosphate + AMP <=> a ribonucleoside 5'-diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75742", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH <=> 10-oxooctadecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9794475", "l": "Cipro:ALB dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31353", "l": "(S)-2,3-epoxysqualene + H2O => lupan-3beta,20-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691167", "l": "CUL1, SKP1, FBXL5 bind (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696564", "l": "USP25 deubiquitinates DDX58 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34791", "l": "2-hydroxyethylphosphonate + O2 = formate + H(+) + hydroxymethylphosphonate", "d": []}, {"i": "EC:1.13.11.72", "l": "\"2-hydroxyethylphosphonate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14083", "l": "D-glyceraldehyde 3-phosphate + indole => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55362", "l": "9-cis-retinol => 11-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11510", "l": "3-hydroxy-L-aspartyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635845", "l": "GLI proteins bind CDC73 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187045", "l": "The signal peptide is excised from beta-NGF pre-pro-precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29727", "l": "ethane-1-sulfonate + FMNH2 + O2 = acetaldehyde + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61382", "l": "2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate => 2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33956", "l": "DIBOA + UDP-alpha-D-glucose => DIBOA beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53967", "l": "4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin <=> gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434047", "l": "phosphorylation of IRAK2 by activated IRAK4  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688294", "l": "SIRT5 deacetylates Cytochrome C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63950", "l": "phosphate + sphinga-4E,14Z-dienine => H2O + sphinga-4E,14Z-dienine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54853", "l": "H(+) + heptan-4-one + NADPH + O2 => H2O + NADP(+) + propyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.22", "l": "\"cyclin-dependent kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12815", "l": "D-glutamate => L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5228992", "l": "ROCK1,ROCK2 are activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964525", "l": "RBL1 gene expression is repressed by the DREAM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645481", "l": "TIFA oligomerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103100", "l": "UDP-glucose: 6-methylthiohexylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 6-methylthiohexylhydroximate <=> H+ + 5-methylthiopentyldesulfoglucosinolate + UDP(3-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392513", "l": "Rap1 signal termination by Rap1GAPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9669893", "l": "KIT binds type I TKIs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2203480", "l": "COLEC11 binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134953", "l": "DHX36 or DHX9 binds MyD88 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27669", "l": "(R)-methylmalonyl-CoA + H(+) <=> CO2 + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49355", "l": "2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32456", "l": "(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20264", "l": "3,5,7-trioxododecanoyl-CoA <=> CO2 + CoA + olivetol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28792", "l": "5,6-dihydrothymine + NAD(+) => H(+) + NADH + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050423", "l": "thiamine oxidase activity", "d": ["Catalysis of the reaction: thiamine + 2 O2 = thiamine acetic acid + 2 H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800035", "l": "IGFBP3 binds TMEM219 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51456", "l": "H2O + N-(9Z-octadecenoyl)-L-isoleucine = (9Z)-octadecenoate + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050506", "l": "vomilenine glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-glucose + vomilenine = H+ + raucaffricine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33707", "l": "ATP + L-threonine = ADP + H(+) + O-phospho-L-threonine", "d": []}, {"i": "EC:2.7.1.177", "l": "\"L-threonine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362427", "l": "Hh-Np binds GPC5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034877", "l": "isonicotinate dehydrogenase activity", "d": ["Catalysis of the reaction: isonicotinate + acceptor + H2O = 2-hydroxyisonicotinate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41591", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70132", "l": "3-dehydro-6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6-dehydro-28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018768", "l": "RHOU auto-activates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42210", "l": "a (Z)-omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+) => a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948536", "l": "PTENP1 mRNA binds miR-20 RISC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47210", "l": "2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202233", "l": "Inactivation of Lck by Csk (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68111", "l": "L-glucitol + NAD(+) <=> H(+) + keto-L-fructose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031715", "l": "C5L2 anaphylatoxin chemotactic receptor binding", "d": ["Binding to a C5L2 anaphylatoxin chemotactic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41055", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33601", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31265", "l": "but-3-yn-1-ol + pyrroloquinoline quinone => but-3-ynal + H(+) + pyrroloquinoline quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004999", "l": "vasoactive intestinal polypeptide receptor activity", "d": ["Combining with vasoactive intestinal polypeptide to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60143", "l": "dodecanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxotetradecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-177284", "l": "PKA phosphorylates PDE4B (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13370", "l": "dimethylallyl diphosphate => diphosphate + isoprene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10000", "l": "H2O + pentanamide = NH4(+) + pentanoate", "d": []}, {"i": "EC:3.5.1.50", "l": "\"pentanamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27822", "l": "hydrogen sulfide + O-acetyl-L-homoserine = acetate + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70146", "l": "6alpha-hydroxy-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 28-nortyphasterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65929", "l": "3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine => 3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944266", "l": "Association of procollagen type XI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57328", "l": "acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] = CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2328037", "l": "Fibrillin-1 binds integrins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46692", "l": "4-hydroxybenzoate + ATP + H(+) = 4-hydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030377", "l": "urokinase plasminogen activator receptor activity", "d": ["Combining with the urokinase plasminogen activator to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62137", "l": "dGMP + GTP => dGDP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2534378", "l": "Hv1 Mediated H+ Permeability (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25964", "l": "(R)-benzoin + NADP(+) = benzil + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.321", "l": "\"benzil reductase [(R)-benzoin forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45022", "l": "H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine => L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49119", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate <=> deoxyviolaceinate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990525", "l": "BIR domain binding", "d": ["Binding to a Baculovirus Inhibitor of apoptosis protein Repeat (BIR) domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21137", "l": "(R)-carnitine + acetyl-CoA => CoA + O-acetyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5226999", "l": "ADD1:ADD3 binds DMTN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30898", "l": "H2O + O2 + propane-1,3-diamine <=> 3-aminopropanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851011", "l": "TRIM27 polyubiquitinates PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8957241", "l": "TP73 tetramer translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72354", "l": "glutarate(in) + glycocholate(out) <=> glutarate(out) + glycocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58068", "l": "(E)-isoeugenol + O2 = acetaldehyde + vanillin", "d": []}, {"i": "EC:1.13.11.88", "l": "\"isoeugenol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68287", "l": "hexanoyl-CoA + L-seryl-[protein] <=> CoA + O-hexanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166817", "l": "Cleavage of C3 by C3 convertases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22370", "l": "D-xylulose 5-phosphate => L-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61139", "l": "(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + quercetin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182990", "l": "Sprouty sequesters CBL away from active EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58193", "l": "dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin => dihydrobisanhydrobacterioruberin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38995", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9681294", "l": "IL6R binds IL6R inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27565", "l": "all-trans-nonaprenyl diphosphate + 7 diphosphate => (2E)-geranyl diphosphate + 7 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53184", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63840", "l": "[thioredoxin]-dithiol + tert-butyl hydroperoxide = [thioredoxin]-disulfide + H2O + tert-butanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19043", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49383", "l": "5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24095", "l": "2 H(+) + O2 + 2 sulochrin <=> 2 (2S)-bisdechlorogeodin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47419", "l": "an NDP-alpha-D-glucose + D-glucose <=> a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425861", "l": "Activation of Protein Kinase C novel isoforms (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209891", "l": "Dopamine is oxidised to noradrenaline (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53985", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42782", "l": "4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391168", "l": "SIRP gamma binds CD47 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19243", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57868", "l": "(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 = (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.62", "l": "\"trans-4-coumaroyl-CoA 2'-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686578", "l": "Activated ATM phosphorylates ABL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690152", "l": "USP5 cleaves polyubiquitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29888", "l": "ATP + H2O + L-lysine(out) => ADP + H(+) + L-lysine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41030", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-377644", "l": "Release of CSK from SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173709", "l": "C7 binds C5b:C6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21935", "l": "S-adenosyl-L-methionine <=> L-homoserine lactone + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38705", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69550", "l": "CO2 + phosphoethanolamine => H(+) + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73552", "l": "GDP(out) + UTP(in) => GDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001531", "l": "interleukin-21 receptor binding", "d": ["Binding to an interleukin-21 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853762", "l": "RET dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0016595", "l": "glutamate binding", "d": ["Binding to glutamate, the anion of 2-aminopentanedioic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247837", "l": "WNT ligands traffic to the Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218811", "l": "DOCK180:ELMO binds CRK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54283", "l": "2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870703", "l": "SOD2 (MnSOD) gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707516", "l": "FeHM dissociates from MetHb (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454689", "l": "14-3-3 Binds p-S237-TBC1D1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60738", "l": "(2E,6E)-farnesoate + 2 H(+) + NADPH => (2E,6E)-farnesal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30515", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + S-methyl-5'-thioadenosine + thermospermine", "d": []}, {"i": "EC:2.5.1.79", "l": "\"thermospermine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74908", "l": "(2E)-but-2-enoyl-AMP + holo-[ACP] => (2E)-butenoyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16506", "l": "chorismate => 4-hydroxybenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351341", "l": "Exocytosis of Proactivator polypeptide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667563", "l": "AVPR2 bind desmopressin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37303", "l": "ATP + glycyl-L-asparagine(out) + H2O = ADP + glycyl-L-asparagine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433451", "l": "JAK2 binds to p-KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592316", "l": "Initial activation of proMMP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20986", "l": "an N-acylsphing-4-enine 1-phosphate + choline + H(+) => a sphingomyelin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31711", "l": "beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.152", "l": "\"beta-amyrin 11-oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33973", "l": "phosphate + ribostamycin => 5''-phosphoribostamycin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15107", "l": "H(+) + kaempferide + S-adenosyl-L-homocysteine => kaempferol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3229181", "l": "CALM1:Ca2+ binds CNG channel (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004861", "l": "cyclin-dependent protein serine/threonine kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39052", "l": "ATP + cholesterol(in) + H2O => ADP + cholesterol(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686930", "l": "RIPK3 is cleaved by CASP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24830", "l": "ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide => ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390846", "l": "D2D3,4 bind to DA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0086008", "l": "voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44744", "l": "4 H(+) + 4 malonyl-CoA = (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O", "d": []}, {"i": "EC:2.3.1.246", "l": "\"3,5-dihydroxyphenylacetyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13359", "l": "3-oxopropanoate + H(+) + NADH => 3-hydroxypropanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54543", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] <=> beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617454", "l": "HOXB1 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30776", "l": "H2O + O2 + pyridoxamine => H2O2 + NH4(+) + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050284", "l": "sinapate 1-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + sinapate = UDP + 1-sinapoyl-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021364", "l": "ELF3 binds NOTCH3 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36710", "l": "O-ureido-L-serine <=> O-ureido-D-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41619", "l": "D-ribose 2,5-bisphosphate + H2O <=> D-ribose 5-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56625", "l": "2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624131", "l": "UNC119B binds myristoylated proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28923", "l": "H(+)(in) + L-phenylalanine(in) = H(+)(out) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27290", "l": "A + formate + H(+) = AH2 + CO2", "d": []}, {"i": "EC:1.17.98.4", "l": "\"formate dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67415", "l": "alpha-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432559", "l": "PER is phosphorylated by DCO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25854", "l": "an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9644879", "l": "NPAS4:ARNT2 binds BDNF gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70971", "l": "citrate <=> isocitrate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700142", "l": "Active ALK binds FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686710", "l": "Cleavage of S protein into S1:S2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55804", "l": "(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O = (9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51048", "l": "5alpha-androstan-3,17-dione + A = AH2 + androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.958976004066542", "identifiers": [{"i": "GO:0019956", "l": "chemokine binding", "d": ["Binding to a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9022314", "l": "HIPK2 phosphorylates MECP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42305", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15540", "l": "(2R)-3-sulfolactate + NADP(+) <=> 3-sulfopyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52877", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate => 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59311", "l": "D-galactono-1,5-lactone + H2O <=> D-galactonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44756", "l": "2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30306", "l": "(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73455", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + salvigenin = 8-hydroxysalvigenin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160042", "l": "purine nucleotide uniporter activity", "d": ["Catalysis of the active transport of purine nucleotides across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379464", "l": "COMT transfers Met to DOPAC to form HVA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52657", "l": "a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) => a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013006", "l": "RHOA:GTP translocates to the ER membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73148", "l": "adenosine 3',5'-bisphosphate(out) + FAD(in) => adenosine 3',5'-bisphosphate(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400434", "l": "FFAR1 binds fatty acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5138459", "l": "WNT5A:FZD4 is endocytosed (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68323", "l": "1D-myo-inositol 2,4,5-triphosphate + H2O <=> 1D-myo-inositol 2,5-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008142", "l": "oxysterol binding", "d": ["Binding to oxysterol, an oxidized form of cholesterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376121", "l": "Bnip2 interacts with CDO complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69739", "l": "phenylsuccinate + succinyl-CoA = 3-phenylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655483", "l": "USP1 autocleavage (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689111", "l": "PARK2 autoubiquitinates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851979", "l": "BTNL9 binds immune cell surfaces (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75329", "l": "chloride(in) + D-tryptophan(in) + 2 Na(+)(in) => chloride(out) + D-tryptophan(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9604328", "l": "AKT1 phosphorylates NOTCH4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.155424086811493", "identifiers": [{"i": "GO:0016651", "l": "oxidoreductase activity, acting on NAD(P)H", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8960973", "l": "RLBP1:11cRAL dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23436", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71077", "l": "L-arginine(out) + L-cystine(in) => L-arginine(in) + L-cystine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43070", "l": "4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase] => beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140835", "l": "RNA polymerase II CTD heptapeptide repeat T4 kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphothreonine (position 4)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428273", "l": "SPHK1 phosphorylates SPG to S1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39900", "l": "7-deoxyloganetin + UDP-alpha-D-glucose => 7-deoxyloganin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66347", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17110", "l": "FMNH2 + N-methylnicotinate + O2 => (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473596", "l": "Collagen type I degradation by MMP15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373148", "l": "succinate + CoASH + GTP <=> succinylCoA + GDP + Pi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225919", "l": "Phospho R-SMAD(SMAD2,3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43588", "l": "globoside NORint + UDP-alpha-D-galactose = globoside NOR2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61636", "l": "ATP + CoA + isophthalate = AMP + diphosphate + isophthalyl-CoA", "d": []}, {"i": "EC:6.2.1.58", "l": "\"isophthalate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71182", "l": "L-histidine(out) + L-tryptophan(in) <=> L-histidine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0050236", "l": "pyridoxine:NADP 4-dehydrogenase activity", "d": ["Catalysis of the reaction: NADP+ + pyridoxine = H+ + NADPH + pyridoxal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49086", "l": "(-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29406", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 <=> 3-demethylubiquinol-8 + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51374", "l": "CoA + H(+) + N-(9Z-hexadecenoyl)-glycine => (9Z)-hexadecenoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19256", "l": "a sphingomyelin + H2O <=> an N-acylsphing-4-enine + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75947", "l": "L-arginine + taurine = L-ornithine + taurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755303", "l": "26S proteasome degrades HIFalpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27344", "l": "AH2 + NH4(+) + O2 <=> A + H(+) + H2O + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170810", "l": "nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48363", "l": "a 1,2-saturated fatty acid + H2O2 <=> a 2-hydroxy fatty acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114419", "l": "Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205289", "l": "Autophosphorylation of KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418859", "l": "Phosphorylation of Unc5C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416516", "l": "GRK2 sequesters activated Gq (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45285", "l": "eicosanoyl-CoA + sphing-4-enine => CoA + H(+) + N-eicosanoyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15846", "l": "4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose => 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632970", "l": "MSH6 variant:MSH2-defective DNA mismatch repair (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018768", "l": "RHOU auto-activates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380780", "l": "Activation of Src (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51395", "l": "(9Z)-octadecenoyl-CoA + serotonin <=> CoA + H(+) + N-(9Z-octadecenoyl)-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67369", "l": "H2O + N-acetyl-L-glutamine => acetate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40613", "l": "2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate => H2O + trihexanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34007", "l": "7-dehydrodesmosterol + S-adenosyl-L-methionine = 5-dehydroepisterol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67507", "l": "1-nonadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66553", "l": "L-glutaminyl-[protein] + serotonin => 5-serotonyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9609310", "l": "β-blockers bind ADRB1,2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17393", "l": "3-maleylpyruvate = 3-fumarylpyruvate", "d": []}, {"i": "EC:5.2.1.4", "l": "\"maleylpyruvate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36167", "l": "a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate", "d": []}, {"i": "EC:3.1.3.89", "l": "\"5'-deoxynucleotidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55429", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16416", "l": "(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + L-lysyl-[glycine-cleavage complex H protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008479", "l": "FBXW7 polyubiquitinates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72644", "l": "1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine => 1,6-dimethoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39656", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60943", "l": "(9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769115", "l": "MAPK1,(MAPK3) phosphorylates NPAS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37000", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674095", "l": "PDGFRs bind type II TKI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57906", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102066", "l": "alpha-patchoulene synthase activityy", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphoric acid + alpha-patchoulene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389862", "l": "Conversion of glyoxylate to oxalate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73232", "l": "2,4,6-trichlorophenol + FADH2 + O2 => 2-chloro-6-hydroxy-1,4-benzoquinone + 2 chloride + FAD + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34100", "l": "carboxynorspermidine + H(+) => CO2 + norspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18126", "l": "A + a D-alpha-amino acid + H2O => a 2-oxocarboxylate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60342", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31655", "l": "4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O = 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18074", "l": "(S)-dihydroorotate + A => AH2 + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247514", "l": "SCARF1:ligand is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008428", "l": "ribonuclease inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of ribonuclease."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351207", "l": "Spermine  => N-acetylated spermine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65082", "l": "asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => asperaculane D + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.42", "l": "\"thermopsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58511", "l": "(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O <=> (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10460", "l": "prostaglandin A1 = prostaglandin C1", "d": []}, {"i": "EC:5.3.3.9", "l": "\"prostaglandin-A1 Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34710", "l": "AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22099", "l": "phosphate + RNA(n+1) <=> a ribonucleoside 5'-diphosphate + RNA(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63851", "l": "2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2 <=> 2 3',4'-dihydroxyaurone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18791", "l": "D-galactosamine 6-phosphate => D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39201", "l": "(2E)-tetracosenoyl-CoA + H2O => (3R)-hydroxytetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70559", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696958", "l": "USP44 deubiquitinates CDC20 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937807", "l": "SRC phosphorylates RUNX3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019981", "l": "interleukin-6 binding", "d": ["Binding to interleukin-6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53987", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938440", "l": "miR-17 binds RUNX1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404134", "l": "RBP4:atROL binds TTR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28976", "l": "H(+)(out) + L-asparagine(in) => H(+)(in) + L-asparagine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28760", "l": "beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose => alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1011598", "l": "DOCKs bind to RhoGEFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27393", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 = dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30413", "l": "benzyl benzoate + CoA => benzoyl-CoA + benzyl alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16661", "l": "fluoride + S-adenosyl-L-methionine = 5'-deoxy-5'-fluoroadenosine + L-methionine", "d": []}, {"i": "EC:2.5.1.63", "l": "\"adenosyl-fluoride synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21335", "l": "acetyl-CoA + D-glucosamine <=> CoA + H(+) + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205319", "l": "Interaction of APS and p-KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38957", "l": "an N-acylsphing-4-enine 1-phosphate(out) => an N-acylsphing-4-enine 1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50960", "l": "cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682826", "l": "LGI1 binds ADAM11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72299", "l": "3,3',5-triiodo-L-thyronine(out) + L-glutamate(in) = 3,3',5-triiodo-L-thyronine(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55544", "l": "L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018756", "l": "RHOH binds GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202721", "l": "JAM2 binds JAM3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694452", "l": "Protein E forms a homopentamer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003851", "l": "2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72504", "l": "glutarate(in) + prostaglandin F2alpha(out) => glutarate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204850", "l": "Interaction of Tie2 and Dok-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11757", "l": "ATP + biotin + L-lysyl-[protein] => AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9646468", "l": "mTORC1 binds RHEB:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51995", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451283", "l": "kainate receptor binds glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218906", "l": "RIPK3 phosphorylates MLKL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982807", "l": "JAK2 phosphorylation of GHR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21723", "l": "formamide <=> H2O + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57571", "l": "7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54002", "l": "(11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10462", "l": "prostaglandin C1 => prostaglandin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390061", "l": "YKI binds to phosphorylated WTS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983153", "l": "E1 mediated ubiquitin activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73266", "l": "genkwanin + S-adenosyl-L-methionine <=> apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72676", "l": "3',5'-cyclic CMP + H2O => CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375138", "l": "CDO binds BOC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928641", "l": "PAK binds RAC and bPIX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48445", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol => a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56221", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380949", "l": "AMPK is dephosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43350", "l": "cholesteryl (9Z-octadecenoate)(out) => cholesteryl (9Z-octadecenoate)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.51", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5195402", "l": "CDK1 phosphorylates LPIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58469", "l": "2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2 => 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419841", "l": "Light stimulates opsin receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264615", "l": "Loading of acetylcholine in synaptic vesicles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45442", "l": "H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate => H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047029", "l": "(R)-4-hydroxyphenyllactate dehydrogenase (NADPH) activity", "d": ["Catalysis of the reaction: NADP+ + (R)-3-(4-hydroxyphenyl)lactate = NADPH + H+ + 3-(4-hydroxyphenyl)pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29523", "l": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)", "d": []}, {"i": "EC:2.4.1.131", "l": "\"GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52524", "l": "O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390835", "l": "DRD1,5 bind DA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43787", "l": "adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32004", "l": "(+)-copalyl diphosphate => diphosphate + isopimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31834", "l": "(2E,6E)-farnesyl diphosphate <=> delta-guaiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23168", "l": "coformycin + NADP(+) = 8-oxocoformycin + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.235", "l": "\"8-oxocoformycin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16898", "l": "a 3beta-hydroxysteroid + a triacylglycerol => a 3beta-hydroxysteroid ester + a diacylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75172", "l": "Formation of RAD50:MRE11 complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57443", "l": "2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] <=> 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102743", "l": "eriodictyol,NADPH:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: H+ + eriodictyol + NADPH + O2 <=> 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate(1-) + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24392", "l": "dTDP-L-dihydrostreptose + streptidine 6-phosphate = dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate", "d": []}, {"i": "EC:2.4.2.27", "l": "\"dTDP-dihydrostreptose--streptidine-6-phosphate dihydrostreptosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42419", "l": "a ubiquinone + L-proline <=> (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0047801", "l": "L-cysteine transaminase activity", "d": ["Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.13.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12589", "l": "ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GM2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762345", "l": "PREDN:ALB dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11920", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O", "d": []}, {"i": "EC:4.2.1.96", "l": "\"4a-hydroxytetrahydrobiopterin dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49971", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32160", "l": "AH2 + epoxyqueuosine(34) in tRNA => A + H2O + queuosine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19847", "l": "H(+) + isonocardicin A + S-methyl-5'-thioadenosine => nocardicin E + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75771", "l": "(9Z,12Z,15Z)-octadecatrienoate + H2O = (10S)-hydroxy-(12Z,15Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.4", "l": "\"phospholipase A2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047296", "l": "homospermidine synthase activity", "d": ["Catalysis of the reaction: 2 putrescine = NH3 + sym-homospermidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39968", "l": "2-aminobut-2-enoate => 2-iminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400434", "l": "FFAR1 binds fatty acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38399", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388831", "l": "Phosphorylation of CD28 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062081", "l": "activating MHC class Ib receptor activity", "d": ["Combining with a MHC class Ib protein complex to mediate signaling that activates a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72462", "l": "fumarate(in) + L-aspartate(out) <=> fumarate(out) + L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72508", "l": "2-oxoglutarate(in) + prostaglandin F2alpha(out) => 2-oxoglutarate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432897", "l": "ILK interacts with beta-1 integrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42781", "l": "adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53873", "l": "CTP + D-ribose 5-phosphate + H(+) => CDP-D-ribose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015506", "l": "nucleoside:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + H+(out) = nucleoside(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74502", "l": "H(+) + NADPH + yaequinolone D <=> H2O + NADP(+) + penigequinolone A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.938386572175233", "identifiers": [{"i": "GO:0008017", "l": "microtubule binding", "d": ["Binding to a microtubule, a filament composed of tubulin monomers."]}, {"i": "REACT:R-HSA-9614343", "l": "Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65728", "l": "2-oxoglutarate + hexyl sulfate + O2 = CO2 + H(+) + hexanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.55", "l": "\"2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13206", "l": "a monosaccharide 1-phosphate + H(+) + UTP => a UDP-monosaccharide + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49141", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71114", "l": "L-phenylalanine(out) + S-methylmercury-L-cysteine(in) <=> L-phenylalanine(in) + S-methylmercury-L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033966", "l": "N-substituted formamide deformylase activity", "d": ["Catalysis of the reaction: N-benzylformamide + H2O = formate + benzylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163798", "l": "Furin cleaves pro-protein Z to protein Z (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199154", "l": "CD200 binds to CD200R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62623", "l": "[thioredoxin]-dithiol + a hydroperoxide <=> [thioredoxin]-disulfide + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21404", "l": "chloride + O2 = chlorite", "d": []}, {"i": "EC:1.13.11.49", "l": "\"chlorite O2-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047294", "l": "phosphoglycerol geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = sn-3-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53256", "l": "lathosterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73439", "l": "(2S)-naringenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-carthamidin-4',7-dimethyl ether + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047039", "l": "tetrahydroxynaphthalene reductase activity", "d": ["Catalysis of the reaction: NADP+ + scytalone = NADPH + H+ + 1,3,6,8-naphthalenetetrol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34338", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (22R)-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10179", "l": "(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) <=> (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.42", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46326", "l": "3-oxochola-4,17-dien-22-oyl-CoA + AH2 => 3-oxochol-4-en-22-oyl-CoA + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58151", "l": "ethyl acetate + H2O <=> acetate + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629679", "l": "PDE3A inhibitors bind PDE3A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53040", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25627", "l": "H2O2 + imidazole-4-acetaldehyde + NH4(+) => H2O + histamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17187", "l": "GMP + 2 H(+) + NADPH => IMP + NADP(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814088", "l": "SYS1 binds AcM-ARFRP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52165", "l": "O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] => (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676071", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63685", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP => (4R,5S)-dethiobiotin + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10303", "l": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate <=> (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874080", "l": "SRC phosphorylates PTK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850818", "l": "SPINK9 binds KLK5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74007", "l": "dimethylallyl diphosphate + H2O + yaequinolone E = [(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222093", "l": "BRD7 binds TP53 and EP300 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28801", "l": "glycine + L-proline => H2O + L-prolinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60261", "l": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75850", "l": "Addition of the third nucleotide on the nascent transcript (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48071", "l": "ganglioside GM2 (d18:1(4E)) + H2O <=> ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26310", "l": "1,4-dihydroxy-2-naphthoyl-CoA + H2O => 1,4-dihydroxy-2-naphthoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47695", "l": "AH2 + neomycin C + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40442", "l": "6-sulfo-beta-D-quinovose <=> 6-deoxy-6-sulfo-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63022", "l": "(9Z,12Z)-octadecadienoate + NH4(+) => (9Z,12Z)-octadecadienamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75906", "l": "ADP-D-glycero-beta-D-manno-heptose + L-seryl-[protein] <=> ADP + H(+) + O-(D-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660965", "l": "CCL17 and CCL22 genes are transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0036313", "l": "phosphatidylinositol 3-kinase catalytic subunit binding", "d": ["Binding to the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23328", "l": "a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12081", "l": "acetyl-CoA + H(+) + malonyl-[ACP] => 3-oxobutanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40209", "l": "(3S)-hydroxytetradecanedioyl-CoA => (2E)-tetradecenedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204861", "l": "Interaction of Tie2 and Shc1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047943", "l": "glutamate-methylamine ligase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP + methylammonium = N(5)-methyl-L-glutamine + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017056", "l": "structural constituent of nuclear pore", "d": ["The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109702", "l": "PDPK1 phosphorylates AKT2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25701", "l": "H(+) + N,N-dihydroxy-L-hexahomomethionine <=> (E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032143", "l": "single thymine insertion binding", "d": ["Binding to a double-stranded DNA region containing a single thymine insertion or a deletion that results in an unpaired thymine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52621", "l": "3-methylbutanoyl-CoA => 2,2-dimethylpropanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52063", "l": "12-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.47", "l": "\"arabinofuranan 3-O-arabinosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54889", "l": "(1S,2S)-OPC-8 + ATP + CoA => AMP + diphosphate + OPC8-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32189", "l": "cholest-4-en-3-one => cholest-5-en-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27480", "l": "2-oxoglutarate + O2 + thebaine <=> CO2 + formaldehyde + neopinone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797090", "l": "CCNK binds CDK12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39512", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA => (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.28", "l": "\"acrocylindropepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40359", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38924", "l": "a ubiquinone + H(+) + Na(+)(in) + NADH => a ubiquinol + Na(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42599", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 <=> prostaglandin G2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374662", "l": "Translocation of Ezrin to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60305", "l": "N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51733", "l": "glandicoline B + S-adenosyl-L-methionine => H(+) + meleagrin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13768", "l": "bromochloromethane + H2O <=> bromide + chloride + formaldehyde + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37973", "l": "(9Z)-octadecenoyl-CoA + 2 H2O + NADP(+) => H(+) + NADPH + O2 + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663156", "l": "p-BMAL1:p-CLOCK,NPAS2 binds PPARA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57142", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667456", "l": "AVPR1A,B bind desmopressin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351948", "l": "Mitochondrial recruitment of Drp1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35546", "l": "3-phosphooxypyruvate + H2O <=> 3-hydroxypyruvate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39281", "l": "ADP + dodecanoate(in) + H(+) + phosphate => ATP + dodecanoate(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964284", "l": "BTK in active Gq-BTK complex is activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36974", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102545", "l": "phosphatidyl phospholipase B activity", "d": ["Catalysis of the reaction: 2 H2O + a phosphatidylcholine = sn-glycero-3-phosphocholine + 2 H+ + 2 a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49144", "l": "2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate", "d": []}, {"i": "EC:2.6.1.110", "l": "\"dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13641", "l": "H(+) + methane + NADPH + O2 = H2O + methanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23330", "l": "2-cis,4-trans-xanthoxin + a 12'-apo-carotenal => a 9-cis-epoxycarotenoid + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250280", "l": "ROS oxidize thioredoxin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42839", "l": "acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH <=> 5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17416", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.14", "l": "\"procollagen N-endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047133", "l": "dimethylamine dehydrogenase activity", "d": ["Catalysis of the reaction: electron-transferring flavoprotein + H2O + dimethylamine = reduced electron-transferring flavoprotein + formaldehyde + methylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33448", "l": "4beta-methylzymosterol-4alpha-carboxylate + NADP(+) => 3-dehydro-4-methylzymosterol + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10375", "l": "CoA + NAD(+) + phenylglyoxylate <=> benzoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57259", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP <=> GTP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1980125", "l": "ITCH binds DTX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805109", "l": "CDK2 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351208", "l": "Spermidine  => N-acetylated spermidine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014433", "l": "RHOG GEFs activate RHOG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20367", "l": "H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine => phosphoethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0010858", "l": "calcium-dependent protein kinase regulator activity", "d": ["Modulates the activity of a calcium-dependent protein kinase, an enzyme which phosphorylates a protein in a calcium-dependent manner."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36932", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700149", "l": "Active ALK binds PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52690", "l": "3-phenylpyruvate + H(+) + NADH => 3-phenyllactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24986", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin] => (1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769401", "l": "DKK and KRM bind LRP5/6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66628", "l": "(2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2 = (2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37516", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43769", "l": "an alkylamine + L-glutaminyl-[protein] => N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37143", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38319", "l": "chorismate + H2O = (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate", "d": []}, {"i": "EC:3.3.2.13", "l": "\"chorismatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866856", "l": "RNF5 and RNF185 ubiquitinate CFTR F508del (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70383", "l": "3-oxosphinganine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030544", "l": "Hsp70 protein binding", "d": ["Binding to a Hsp70 protein, heat shock proteins around 70kDa in size."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69711", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphinganine + H2O = beta-D-glucose + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72183", "l": "creatinine(in) + H(+)(out) = creatinine(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.44", "l": "\"[acetyl-CoA carboxylase]-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20232", "l": "2,3-dihydroxybenzoate + ATP + H(+) <=> 2,3-dihydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654651", "l": "Activated FGFR4 binds FRS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67631", "l": "ATP + dGMP + L-aspartate <=> (2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028724", "l": "AMOT proteins bind YAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24218", "l": "(2E,6E)-farnesoate + 2 H(+) + NADH => (2E,6E)-farnesal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60556", "l": "uridine(35) in tRNA(Tyr) = pseudouridine(35) in tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876446", "l": "p-ULK1 phosphorylates DENND3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482772", "l": "Release of platelet cytosolic components (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55935", "l": "3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O <=> AMP + H(+) + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990165", "l": "single-strand break-containing DNA binding", "d": ["Binding to damaged DNA containing single-strand breaks (SSBs)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68423", "l": "cis-(homo)3aconitate + H2O <=> (2R,3S)-iso(homo)3citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16124", "l": "5,6-dihydrouracil + H2O <=> 3-(carbamoylamino)propanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982645", "l": "GRKs bind ADRB2:Catecholamine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24380", "l": "(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)", "d": []}, {"i": "EC:2.1.2.9", "l": "\"methionyl-tRNA formyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41716", "l": "a 2-acyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140586", "l": "promoter-terminator loop anchoring activity", "d": ["Bridging together a cis-regulatory element and a terminator DNA sequences on the chromatin, holding two loop anchors together, maintaining a chromatin loop."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786190", "l": "CMBL hydrolyses OM to OLMS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48289", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM3 => CMP + ganglioside GD3 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24367", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) <=> 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18330", "l": "(1S,3R,5S)-sabinol + NAD(+) => (1S,5S)-sabinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53133", "l": "A + a 3-oxo-Delta(4)-steroid => a 3-oxo-Delta(1,4)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389756", "l": "AKT interacts and phosphorylates Cot (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19901", "l": "L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2", "d": []}, {"i": "EC:1.3.3.10", "l": "\"tryptophan alpha,beta-oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22608", "l": "H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + succinate", "d": []}, {"i": "EC:3.5.1.18", "l": "\"succinyl-diaminopimelate desuccinylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55043", "l": "(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43069", "l": "beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25101", "l": "ATP + UDP <=> ADP + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202291", "l": "Activation of Lck (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44336", "l": "an L-alpha-amino acid + ATP + L-arginine = ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate", "d": []}, {"i": "EC:6.3.2.48", "l": "\"L-arginine-specific L-amino acid ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67495", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358789", "l": "Self-ubiquitination of RNF41 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654399", "l": "Activated FGFR2 binds FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50743", "l": "H2O + leukotriene C4 <=> glycine + leukotriene F4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046899", "l": "nucleoside triphosphate adenylate kinase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44965", "l": "(2E)-dodecenoyl-CoA + H(+) + NADPH => dodecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55292", "l": "pseudouridine(54) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.257", "l": "\"tRNA (pseudouridine(54)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75079", "l": "Formation of AT-AC C complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74464", "l": "(-)-4'-methoxycyclopenine => 4'-methoxyviridicatin + H(+) + methyl isocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64151", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-R + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371591", "l": "Trimerization of cytosolic HSF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791016", "l": "SFTPB binds itself (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29879", "l": "ATP + H2O + L-arginine(out) = ADP + H(+) + L-arginine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68776", "l": "(2Z,6Z)-farnesyl diphosphate = diphosphate + germacrene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73887", "l": "chloride(out) + Na(+)(out) = chloride(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60010", "l": "a tRNA with a 3' CC end + 2 diphosphate => a tRNA precursor + 2 CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050274", "l": "salicyl-alcohol beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: salicyl alcohol + UDP-D-glucose = H+ + salicin + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213207", "l": "Formation of collagen networks (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56502", "l": "CO2 + isopentenyl phosphate + phosphate => (R)-3,5-bisphosphomevalonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45432", "l": "H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693609", "l": "ATM phosphorylates TP53 at S15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20997", "l": "(2Z,4E)-2-aminomuconate + H2O => (3E)-2-oxohex-3-enedioate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71250", "l": "beta-alanine(out) + chloride(out) + 2 Na(+)(out) <=> beta-alanine(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170986", "l": "Ral-GDS binds to Ras-GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690461", "l": "FKBP1A binds tacrolimus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34778", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) <=> a 3-oxosteroid + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71978", "l": "glutathione(out) + 3 Na(+)(out) <=> glutathione(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64443", "l": "glycylglycyl-L-proline(out) + H(+)(out) <=> glycylglycyl-L-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54983", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose <=> [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56295", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651773", "l": "LIG1 binds POLB at long-patch BER site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74068", "l": "ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A => ADP + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.116", "l": "\"averantin hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42330", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51688", "l": "galactitol + NAD(+) = H(+) + keto-L-tagatose + NADH", "d": []}, {"i": "EC:1.1.1.406", "l": "\"galactitol 2-dehydrogenase (L-tagatose-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5218805", "l": "PKC autophosphorylates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432148", "l": "Fgr may phosphorylate p38 MAPK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948034", "l": "FGR binds LDL:LRP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29146", "l": "a ubiquinol + 2 H(+)(in) + nitrate <=> a ubiquinone + 2 H(+)(out) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60955", "l": "(E)-5-hydroxyferulate + S-adenosyl-L-methionine <=> (E)-sinapate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003879", "l": "ATP phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.25.1", "l": "\"proteasome endopeptidase complex\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28354", "l": "decanoyl-CoA + FAD + H(+) = (2E)-decenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14431", "l": "a [oligopeptide](out) + ADP + H(+) + phosphate => a [oligopeptide](in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64567", "l": "8-epi-ilicicolin H <=> ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69395", "l": "an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102090", "l": "adrenaline O-methyltransferase activity", "d": ["Catalysis of the reaction: (R)-adrenaline(1+) + S-adenosyl-L-methionine <=> metanephrine + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088152", "l": "FOXM1 stimulates CDC25A transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60756", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone = cinerin I + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19872", "l": "an acyl-CoA + glycine <=> an N-acylglycine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27794", "l": "(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + 4 diphosphate", "d": []}, {"i": "EC:2.5.1.30", "l": "\"heptaprenyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66526", "l": "L-ascorbate(out) + monodehydro-L-ascorbate radical(in) => L-ascorbate(in) + monodehydro-L-ascorbate radical(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047790", "l": "creatinine deaminase activity", "d": ["Catalysis of the reaction: creatinine + H2O = N-methylhydantoin + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11424", "l": "ATP + L-threonyl-[myosin heavy-chain] = ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain]", "d": []}, {"i": "EC:2.7.11.7", "l": "\"[myosin heavy-chain] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73406", "l": "(2R,3R)-tartrate(in) + sulfate(out) <=> (2R,3R)-tartrate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624951", "l": "TNPO1 binds KIF17 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432642", "l": "Phosphorylated TIM transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183072", "l": "EGFR non-clathrin mediated endocytosis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17030", "l": "(S)-allantoin + H2O => allantoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29155", "l": "2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) = 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45334", "l": "7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+) => 7,8-dihydroneopterin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70721", "l": "L-alanine(out) => L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72748", "l": "leukotriene E4(out) => leukotriene E4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68954", "l": "Mcm2-7 is phosphorylated by DDK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61778", "l": "H(+) + rebaudioside M + UDP => rebaudioside D + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011543", "l": "DCA binds PDK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046175", "l": "Further sulfation on galactose residues produces KSPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41496", "l": "1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062050", "l": "GPI-mannose ethanolamine phosphate phosphodiesterase activity", "d": ["A phosphoric diester hydrolase activity that removes the ethanolamine phosphate from mannose 2 of a GPI anchor."]}]}
{"type": "biolink:MolecularActivity", "ic": "65.021355091518231", "identifiers": [{"i": "GO:0016755", "l": "aminoacyltransferase activity", "d": ["Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.3.2.-", "l": "\"Aminoacyltransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.3.17", "l": "\"methylthioalkylmalate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69505", "l": "N-acetyl-D-glucosamine + O2 => H2O2 + N-acetyl-D-glucosamino-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048156", "l": "tau protein binding", "d": ["Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29528", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58967", "l": "H2O + hexanal + O2 <=> H(+) + H2O2 + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944229", "l": "Association of procollagen type IX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110036", "l": "C2 domain binding", "d": ["Binding to the C2 domain of a protein, a protein structural domain involved in targeting proteins to cell membranes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507868", "l": "Aquaporins passively transport water into cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14307", "l": "AMP + diphosphate + L-prolyl-tRNA(Pro) => ATP + L-proline + tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63433", "l": "1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112430", "l": "Formation of P-TEFb complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63848", "l": "2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2 = 2 3',4'-dihydroxyaurone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.174", "l": "\"rhamnogalacturonan rhamnohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2203480", "l": "COLEC11 binds ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33772", "l": "a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine => 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733247", "l": "YBX1 binds COL1A2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27635", "l": "5-dehydro-D-gluconate + NADP(+) => 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44102", "l": "2 H(+) + NADH + octanoate => H2O + NAD(+) + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46944", "l": "(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) = H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.958976004066542", "identifiers": [{"i": "GO:0015929", "l": "hexosaminidase activity", "d": ["Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30439", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) = 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": []}, {"i": "EC:2.3.2.17", "l": "\"N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140864", "l": "histone H2AK129 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-129 residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23147", "l": "H2O + N-acetyl-alpha-D-glucosamine + NAD(+) <=> 2 H(+) + N-acetyl-D-glucosaminate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297444", "l": "Binding of cAMP to HCN channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757462", "l": "Hydroxyl radicals oxidize ST to 2,3-DHBA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2169046", "l": "Degradation of TGF-beta receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028583", "l": "Phosphorylation of YAP by LATS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39906", "l": "isoxazolin-5-one + O-acetyl-L-serine <=> 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2206299", "l": "Defective IDUA does not hydrolyse Heparan sulfate chain(6) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448632", "l": "IL34 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23186", "l": "(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23927", "l": "pppGp(2'-5')A <=> 2',3'-cGAMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36762", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine <=> alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25802", "l": "3-acetamidopropanal + H2O2 + spermidine => H2O + N(1)-acetylspermine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010301", "l": "xanthoxin dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + xanthoxin = (+)-abscisic aldehyde + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30546", "l": "(S)-carnitine + ATP + CoA <=> (S)-carnitinyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004507", "l": "steroid 11-beta-monooxygenase activity", "d": ["Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73725", "l": "(2R,3S,11S)-aszonalenin + diphosphate => (S)-benzodiazepinedione + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50038", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine => choloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683653", "l": "Spike protein gets palmitoylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.12", "l": "\"ubiquitinyl hydrolase 1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13789", "l": "[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16943", "l": "H2O + N-acetylisatin => N-acetylindoxyl + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48804", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139906", "l": "Activation of BAD by calcineurin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18105", "l": "ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate", "d": []}, {"i": "EC:7.2.2.10", "l": "\"P-type Ca(2+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69922", "l": "inosine(out) + 2 Na(+)(out) <=> inosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31186", "l": "acetyl-CoA + decanoyl-CoA <=> 3-oxododecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714580", "l": "SLC6A3 binds DRIs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45240", "l": "a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA", "d": []}, {"i": "EC:5.3.3.21", "l": "\"Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44536", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391867", "l": "Fyn binds NCAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72352", "l": "glutarate(in) + glycocholate(out) => glutarate(out) + glycocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.13.2.-", "l": "\"Thioether and trialkylsulfonium hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74809", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31636", "l": "beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O => 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56535", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate <=> N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29280", "l": "H(+) + menaquinol-8 + trimethylamine N-oxide => H2O + menaquinone-8 + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56825", "l": "AH2 + cyclooctat-9-ene-5,7-diol + O2 => A + cyclooctatin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070051", "l": "fibrinogen binding", "d": ["Binding to fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70283", "l": "H2O + N-acetylputrescine + O2 = 4-acetamidobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12341", "l": "L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] => H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66313", "l": "an alpha-mannosylinositol-1-phosphoceramide + H2O => a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67179", "l": "H2O + primary fluorescent dioxobilin-type chlorophyll catabolite <=> H(+) + methanol + O13(4)-desmethyl pFDCC", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605591", "l": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149440", "l": "Transport of VPU to Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749590", "l": "ASA- acetylates ALB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24488", "l": "H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52013", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20779", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose <=> myo-inositol + stachyose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72691", "l": "Formation of the 43S pre-initiation complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690196", "l": "USP8 deubiquitinates RNF128 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6802973", "l": "PLK3 phosphorylates CDC25C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41670", "l": "chelirubine + NADPH => dihydrochelirubine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40191", "l": "(3R)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29745", "l": "2-phenylethylamine(out) => 2-phenylethylamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0005229", "l": "intracellular calcium activated chloride channel activity", "d": ["Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30534", "l": "biotinate sulfoxide + H(+) + NADH <=> biotin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38883", "l": "a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-517705", "l": "p-S318,221-HuR binds mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156930", "l": "GTP-binding activates eEF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418091", "l": "F2R binds ARRB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57610", "l": "3-chlorocatechol + H(+) + NADH => (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50302", "l": "all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin] => all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71790", "l": "2-oxoadipate + O2 <=> (R)-2-hydroxyglutarate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371435", "l": "Constitutive phosphorylation by GSK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39467", "l": "(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH = (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160931", "l": "Disassembly of tight junctions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38519", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396029", "l": "Latent TGF-beta-3 binds integrins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33395", "l": "H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester = GMP + N(alpha)-acetyl-L-lysine methyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22769", "l": "4-nitrophenyl-3-ketovalidamine => 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12878", "l": "acetylacetone + O2 => acetate + H(+) + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17626", "l": "D-lysopine + H2O + NADP(+) => H(+) + L-lysine + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54823", "l": "a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047556", "l": "3,4-dihydroxyphthalate decarboxylase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxyphthalate + H+ = 3,4-dihydroxybenzoate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22405", "l": "beta-D-galacturonate + NAD(+) => D-galactaro-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42271", "l": "2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] <=> 4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047824", "l": "D-iditol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-iditol + NAD+ = D-sorbose + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852019", "l": "MET bound PI3K generates PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36236", "l": "1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186780", "l": "PI3-kinase binds to the active receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.38", "l": "\"isonocardicin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201629", "l": "Caspase-mediated cleavage of Tau (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11681", "l": "ATP + H2O + L-glutamine + XMP => AMP + diphosphate + GMP + 2 H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174367", "l": "GCL ligates L-Glu to L-Cys (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56909", "l": "(7S)-O-acetylsalutaridinol => acetate + H(+) + thebaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39053", "l": "ADP + cholesterol(out) + H(+) + phosphate => ATP + cholesterol(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15162", "l": "4-hydroxyphenylacetate + H(+) + NADH + O2 => H2O + homogentisate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651828", "l": "PARG dePARylates PARP1,PARP2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30838", "l": "H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32228", "l": "(6R)-NADPHX => (6S)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362465", "l": "GHBP binds GHR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25587", "l": "alpha-L-rhamnose <=> beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380316", "l": "Association of NuMA with microtubules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68109", "l": "L-glucitol + NAD(+) => H(+) + keto-L-fructose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64619", "l": "(E)-coniferol + acetyl-CoA <=> (E)-coniferyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41010", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin <=> 6-linalyl-2-O,3-dimethylflaviolin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12103", "l": "1,5-anhydro-D-fructose <=> H2O + microthecin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297275", "l": "CD9:Izumo Binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10185", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O => 3-oxoadipate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30663", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = hapalindole H", "d": []}, {"i": "EC:5.5.1.31", "l": "\"hapalindole H synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18149", "l": "H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "61.466824939696082", "identifiers": [{"i": "GO:0016853", "l": "isomerase activity", "d": ["Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72710", "l": "GDP-beta-L-fucose(in) + GMP(out) <=> GDP-beta-L-fucose(out) + GMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686088", "l": "CASP3 cleaves GSDMD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31409", "l": "all-trans-4,4'-diapolycopene + FADH2 => all-trans-4,4'-diaponeurosporene + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24311", "l": "25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610735", "l": "NUMB binds ITCH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38648", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853762", "l": "RET dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371582", "l": "HSBP1 binds HSF1 trimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0004753", "l": "saccharopine dehydrogenase activity", "d": ["Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32355", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose = 2 H(+) + ternatin C5 + 2 UDP", "d": []}, {"i": "EC:2.4.1.249", "l": "\"delphinidin 3',5'-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190519", "l": "Internalization of gap junction plaques (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54411", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12317", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757574", "l": "ALB binds PREDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660660", "l": "p300 acetylates RELA subunit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29782", "l": "ATP + H2O + L-methionine(out) <=> ADP + H(+) + L-methionine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.3.-.-", "l": "\"Catalysing the translocation of inorganic anions and their chelates\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210277", "l": "Interaction of PECAM-1 and SHP-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110319", "l": "Elongation by POLH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201629", "l": "Caspase-mediated cleavage of Tau (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29359", "l": "H2O + UMP = phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13601", "l": "cis-4-hydroxy-L-proline + NAD(+) = 4-oxo-L-proline + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.104", "l": "\"4-oxoproline reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21892", "l": "D-arabinose + NADP(+) = D-arabinono-1,4-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65659", "l": "A + cholest-1,4-dien-3-one + H2O <=> 25-hydroxycholest-1,4-dien-3-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68161", "l": "N-geranyl-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(8'-hydroxygeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800793", "l": "PIDD1 translocates to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19734", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) => bacteriochlorophyllide a + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43296", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77077", "l": "Capping complex formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444208", "l": "MLNR (GPR38) is a receptor for motilin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682011", "l": "LC3 binds ATG7 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44558", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-hexaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109639", "l": "Formation of the closed pre-initiation complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036082", "l": "extracellular phenylacetaldehyde-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when extracellular phenylacetaldehyde has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416562", "l": "p190RhoGAP binds Plexin-B1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2214351", "l": "PLK1 phosphorylates GORASP1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54801", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein] => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13764", "l": "L-methionine + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + S-methyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783681", "l": "LIF binds LIFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55340", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5665871", "l": "ADRM1 binds 26S proteasome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805546", "l": "Keratin type I binds keratin type II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1861789", "l": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986972", "l": "IL24 binds IL20RA:JAK1:IL20RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47464", "l": "(3E,5Z)-tetradecadienoyl-CoA = (2E,5Z)-tetradecadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48521", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3828025", "l": "DCN (decorin) degradation by MMP14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34660", "l": "C30 botryococcene + S-adenosyl-L-methionine => 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4341072", "l": "SUMOylation of RARA with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70507", "l": "dimethylallyl diphosphate + H2O = dimethylallyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018774", "l": "RHOBTB1 binds GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102087", "l": "N-benzoyl-L-glutamate synthetase activity", "d": ["Catalysis of the reaction: benzoate + L-glutamate + ATP <=> H+ + N-benzoyl-L-glutamate + AMP + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624133", "l": "ARL3:GTP binds the UNC119B complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74229", "l": "L-threonine + tRNA(Ile) => H2O + L-threonyl-tRNA(Ile)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47967", "l": "H2O + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40545", "l": "H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0023023", "l": "MHC protein complex binding", "d": ["Binding to a major histocompatibility complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42608", "l": "a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11996", "l": "biphenyl-2-ol + H(+) + NADH + O2 = biphenyl-2,3-diol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004622", "l": "lysophospholipase activity", "d": ["Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63229", "l": "ATP + spectinomycin => 9-O-adenylylspectinomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59894", "l": "chloride + H(+) + L-propargylglycine => L-2-amino-4-chloropent-4-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050515", "l": "4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity", "d": ["Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25333", "l": "(R)-carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36739", "l": "heptadecasphing-4-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070052", "l": "collagen V binding", "d": ["Binding to a type V collagen trimer."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000298", "l": "endopolyphosphatase activity", "d": ["Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112379", "l": "Recruitment of elongation factors to form elongation complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48926", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine => CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30226", "l": "2 Fe(III)-[cytochrome c] + hydrogen sulfide <=> 2 Fe(II)-[cytochrome c] + H(+) + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30833", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20959", "l": "2-phenylacetate + ATP + CoA <=> AMP + diphosphate + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627369", "l": "SEPT4 binds XIAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73609", "l": "CTP(in) + dCTP(out) => CTP(out) + dCTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73216", "l": "sulfate(out) + thiosulfate(in) => sulfate(in) + thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28010", "l": "propanoyl-CoA + succinate = propanoate + succinyl-CoA", "d": []}, {"i": "EC:2.8.3.27", "l": "\"propanoyl-CoA:succinate CoA transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3301237", "l": "KAT2 complexes acetylate histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71479", "l": "H2O + neurotensin = L-tyrosyl-L-isoleucyl-L-leucine + neurotensin(1-10)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47100", "l": "choloyl-CoA + taurine = CoA + H(+) + taurocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21082", "l": "diphosphate + phosphate + S-adenosyl-L-methionine => ATP + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39572", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32671", "l": "ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate", "d": []}, {"i": "EC:2.7.1.176", "l": "\"UDP-N-acetylglucosamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109858", "l": "MAP2K2 binds MAPK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9709179", "l": "DPP4 binds DPP4 inhibitors (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40398", "l": "1,2-dihydro-beta-NAD + H(+) + O2 <=> H2O2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71623", "l": "malonate(out) + phosphate(in) = malonate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46022", "l": "[pyruvate, water dikinase]-phosphate + AMP + H(+) => [pyruvate, water dikinase] + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015606", "l": "spermidine transmembrane transporter activity", "d": ["Enables the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of a membrane to the other."]}, {"i": "RHEA:35039", "l": "spermidine(in) = spermidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27986", "l": "hydroxyacetone + NADP(+) = H(+) + methylglyoxal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5483238", "l": "Hh processing variants are ubiquitinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350769", "l": "trans-Golgi Network Coat Activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29885", "l": "ADP + H(+) + L-ornithine(in) + phosphate => ATP + H2O + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58898", "l": "4-hydroxybutanoyl-CoA + ADP + phosphate => 4-hydroxybutanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41373", "l": "1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021357", "l": "PRKCI phosphorylates ELF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34993", "l": "L-arginine(in) + L-ornithine(out) => L-arginine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27559", "l": "(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + 3 diphosphate", "d": []}, {"i": "EC:2.5.1.83", "l": "\"hexaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73920", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + H(+) => H2O + norlichexanthone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.214", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14169", "l": "ATP + CoA + glutarate = ADP + glutaryl-CoA + phosphate", "d": []}, {"i": "EC:6.2.1.6", "l": "\"glutarate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69501", "l": "L-arginyl-[protein] + NAD(+) => ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781905", "l": "ZRANB1 binds APC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156678", "l": "Activation of Cdc25C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22576", "l": "an N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine + H(+)", "d": []}, {"i": "EC:3.1.1.81", "l": "\"quorum-quenching N-acyl-homoserine lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32557", "l": "(R)-alpha-terpineol + diphosphate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050180", "l": "phloretin hydrolase activity", "d": ["Catalysis of the reaction: H2O + phloretin = H+ + phloretate + phloroglucinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55534", "l": "2-phenylacetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-phenylalanine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37114", "l": "(15Z)-tetracosenoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759496", "l": "CDH11 nascent mRNA is spliced into the canonical splicing isoform (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36855", "l": "an N-acetyl-L-cysteine-S-conjugate + H2O = acetate + an S-substituted L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24220", "l": "beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase] = (4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.31", "l": "\"ipsdienol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445071", "l": "Reinsertion of L1 into the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688834", "l": "ATXN3 binds VCP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008579", "l": "JUN kinase phosphatase activity", "d": ["Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67218", "l": "(2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55983", "l": "a 1,2-saturated acyl-CoA + an acyl-CoA + H2O <=> an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176956", "l": "Formation of GINS complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193684", "l": "p62 recruits an atypical PKC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25625", "l": "H2O + histamine + O2 = H2O2 + imidazole-4-acetaldehyde + NH4(+)", "d": []}, {"i": "EC:1.4.3.22", "l": "\"diamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161293", "l": "Tropoelastin forms aggregate globules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5676229", "l": "WIPIs bind PI3P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24954", "l": "ADP + H(+) + N-acetyl-D-muramate 6-phosphate => 1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218806", "l": "FYN autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34636", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 => H2O + NADP(+) + pentalenolactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9823816", "l": "OPTN binds CASP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877879", "l": "RUNX1 and FOXP3 bind the RSPO3 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50224", "l": "3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006992", "l": "MECP2 is phosphorylated at S423 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43122", "l": "CO2 + succinate + urate => 2-oxoglutarate + O2 + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63961", "l": "abscisate(out) + ATP + H2O => abscisate(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42923", "l": "S-adenosyl-L-methionine + uridine(1498) in 16S rRNA <=> H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10813", "l": "H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) => 2 H(+) + N-succinyl-L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183067", "l": "Localization of CBL:GRB2 to the membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44641", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + ATP => a 2'-deoxyribonucleoside 5'-triphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30625", "l": "AH2 + all-trans-lycopene => A + all-trans-neurosporene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.63", "l": "\"kynurenine--glyoxylate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004657", "l": "proline dehydrogenase activity", "d": ["Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34685", "l": "alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+) => alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432010", "l": "Aquaporin-1 passively transports water into cell (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866269", "l": "ARRB bind GPCRs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163416", "l": "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18987", "l": "isochorismate => chorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451309", "l": "Edited Kainate Receptor binds glutamate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25711", "l": "L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182988", "l": "Sprouty lures CBL away from EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59519", "l": "acetylsalicylate + L-lysyl-[protein] <=> H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102985", "l": "delta12-fatty-acid desaturase activity", "d": ["Catalysis of the reaction: oleoyl-CoA + O2 + a reduced electron acceptor <=> linoleoyl-CoA + 2 H2O + an oxidized electron acceptor. This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689544", "l": "UCHL5 binds INO80 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53353", "l": "5,6-dihydrouridine(20b) in tRNA + NAD(+) => H(+) + NADH + uridine(20b) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15639", "l": "[alginate](n+1) + GDP + H(+) => [alginate](n) + GDP-alpha-D-mannuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801109", "l": "CHM binds RGGT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36615", "l": "2-hydroxyoctadecanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49322", "l": "(5R,6S)-5,6-epoxi-capsanthin => all-trans-violaxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2203516", "l": "Alpha-1-Microglobulin is cleaved (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23900", "l": "cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11569", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP => 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32591", "l": "(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O = (3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14889", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate", "d": []}, {"i": "EC:5.3.3.13", "l": "\"polyenoic fatty acid isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17328", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA <=> (S)-2-succinylamino-6-oxoheptanedioate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25120", "l": "H2O + L-lysine + NAD(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086223", "l": "Collagen type IX binds integrin alpha11beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448702", "l": "Caspase-1 active tetramer formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20219", "l": "dimethylamine + formaldehyde => H(+) + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798749", "l": "Exocytosis of specific granule lumen proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30459", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol = (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68928", "l": "ATP + H(+) + heptanoate + NADPH = AMP + diphosphate + heptanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14627", "l": "[(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n) => [(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350651", "l": "Caspase-mediated cleavage of MASK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34789", "l": "a 3-oxosteroid + H(+) + NADPH => a 3beta-hydroxysteroid + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25641", "l": "(1R,4S)-menthone + NADP(+) = (R)-pulegone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21811", "l": "2,5-dioxopiperazine + H2O <=> glycylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.55", "l": "\"venombin AB\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42999", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (R)-cembrene A + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030248", "l": "cellulose binding", "d": ["Binding to cellulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50159", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389463", "l": "Proteinase-activated receptors can bind thrombin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15750", "l": "(S)-mandelate + A => AH2 + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51249", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24136", "l": "3'-phosphoadenylyl sulfate + a primary amine = a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}, {"i": "EC:2.8.2.3", "l": "\"amine sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13122", "l": "ATP + shikimate => 3-phosphoshikimate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46738", "l": "a monoacylglycerol + phosphate => H2O + monoacyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26299", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O => 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20270", "l": "4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate => 2 5-dehydro-4-deoxy-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21494", "l": "catechol + CO2 => 2,3-dihydroxybenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52481", "l": "16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] => (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11951", "l": "4-hydroxybenzoyl-CoA + H2O <=> 4-hydroxybenzoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785244", "l": "Defective CYP11B2 does not oxidise 18HCORST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44644", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52776", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.52", "l": "\"camalexin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18129", "l": "2-oxoaldehyde + H2O + NADP(+) = a 2-oxocarboxylate + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.49", "l": "\"2-oxoaldehyde dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52490", "l": "20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71161", "l": "H(+)(out) + L-serine(in) + Na(+)(in) => H(+)(in) + L-serine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448673", "l": "Formation of caspase-1 p10/p20 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65915", "l": "3-hydroxy-L-kynurenine + pyruvate <=> 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11299", "l": "2,5-dioxopentanoate + H2O + NADP(+) <=> 2-oxoglutarate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29770", "l": "ATP + D-methionine(out) + H2O <=> ADP + D-methionine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66840", "l": "asperterpenoid A + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = asperterpenoid B + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433418", "l": "Phosphorylation of JAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9626817", "l": "PKC phosphorylates NCF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619803", "l": "p-S516-ARHGEF7 activates RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429815", "l": "Formation Of Bloc-1 Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.3", "l": "\"pyroglutamyl-peptidase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32457", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone => (-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432010", "l": "Aquaporin-1 passively transports water into cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48717", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 13-oxo-(9Z,11E)-octadecadienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632759", "l": "TP53 binds the SCO2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851888", "l": "MET binds SHC1-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70868", "l": "L-alanine(out) + L-glutamine(in) + Na(+)(out) => L-alanine(in) + L-glutamine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.87", "l": "\"3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709842", "l": "MAVS binds TOMM70 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60802", "l": "CO2 + gibberellin A44 + succinate => 2-oxoglutarate + gibberellin A53 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035501", "l": "MH1 domain binding", "d": ["Binding to a MH1 (MAD homology 1) protein domain. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71612", "l": "(S)-malate(in) + malonate(out) => (S)-malate(out) + malonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31602", "l": "FMNH2 + NADH + O2 + thymine <=> (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28055", "l": "2-oxobutanoate + CoA => formate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399939", "l": "Autophosphorylation of PAK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39801", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13203", "l": "guanidinoacetate + L-ornithine => glycine + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16914", "l": "a CDP-1,2-diacyl-sn-glycerol + L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676160", "l": "AAMP binds NOD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701147", "l": "TRPV1 binds TRPV1 blockers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34300", "l": "2'-deamino-2'-hydroxyneamine + 2-oxoglutarate => 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042498", "l": "diacyl lipopeptide binding", "d": ["Binding to a lipopeptide containing a nonprotein moiety consisting of two acyl groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51161", "l": "cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034321", "l": "alcohol O-octanoyltransferase activity", "d": ["Catalysis of the reaction: octanoyl-CoA + an alcohol = CoA + an octyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30864", "l": "4-O-phospho-L-tyrosine + H2O => L-tyrosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63394", "l": "AH2 + Fe(II)-heme i => A + Fe(II)-heme o + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211191", "l": "Association of DFF with alpha:beta importin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64641", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose => lactose + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33291", "l": "L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10701", "l": "H2O + limonene 1,2-epoxide => limonene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53607", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68116", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol = a triacylglycerol + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54209", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 => 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878056", "l": "RUNX1:CBFB binds EP300 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27499", "l": "3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine => 3'-O-methyltricetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48335", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23535", "l": "ATP + cholate + CoA <=> AMP + choloyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196857", "l": "PANK2 phosphorylates PanK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.62", "l": "\"5-deoxyribulose 1-phosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60869", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O => a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111879", "l": "PIP2 hydrolysis (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050049", "l": "leucine dehydrogenase activity", "d": ["Catalysis of the reaction: L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17172", "l": "acetyl-CoA + alpha-D-galactosamine 1-phosphate <=> CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72619", "l": "2-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25639", "l": "2 H(+) + NADH + sulfoacetate => H2O + NAD(+) + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40321", "l": "(2E)-tetracosenoyl-CoA + H2O2 => O2 + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75075", "l": "dihydro-6-demethylsterigmatocystin + S-adenosyl-L-methionine = dihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374899", "l": "Release of noradrenaline  at the synapse (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68228", "l": "glycine(in) + Na(+)(in) = glycine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69299", "l": "CDT1 binds geminin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76118", "l": "2-oxoglutarate + O2 + thebaine <=> 6-O-demethylthebaine + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389350", "l": "Activation of Cdc42 by pVav1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71751", "l": "2-oxoglutarate(out) + glutarate(in) = 2-oxoglutarate(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749197", "l": "ORC1 binds to H4K20me2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42808", "l": "2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-L-Glu)(n) = 3 reduced coenzyme F420-(gamma-L-Glu)(n) + sulfite", "d": []}, {"i": "EC:1.8.98.3", "l": "\"sulfite reductase (coenzyme F420)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68045", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9773218", "l": "CDH19 associates with catenins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0052743", "l": "inositol tetrakisphosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26314", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate => dihydroxyacetone phosphate + L-aspartate 4-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75812", "l": "acetoacetate(out) + Na(+)(out) => acetoacetate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31089", "l": "3-oxodecanoyl-CoA + CoA => acetyl-CoA + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190245", "l": "FGFR1b binds to FGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29039", "l": "ATP + H2O + L-aspartate(out) = ADP + H(+) + L-aspartate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64555", "l": "(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45939", "l": "3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60776", "l": "2-oxoglutarate + gibberellin A12 + O2 = CO2 + gibberellin A15 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769011", "l": "NPAS4 binds GEM gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050510", "l": "N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018530", "l": "(R)-6-hydroxynicotine oxidase activity", "d": ["Catalysis of the reaction: (R)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30823", "l": "UDP-N-acetyl-alpha-D-glucosamine = H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}, {"i": "EC:4.2.1.135", "l": "\"UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42207", "l": "corticosterone + NAD(+) <=> 11-dehydrocorticosterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62542", "l": "dihydroouabain + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 3 H(+) + ouabain", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16824", "l": "6-phospho-D-gluconate + NAD(+) <=> 6-phospho-2-dehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74087", "l": "an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP = ADP + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.7", "l": "\"aldehyde dehydrogenase (FAD-independent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047603", "l": "acetoacetyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: acetoacetyl-CoA + H2O = acetoacetate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49466", "l": "CO2 + resorcinol => 2,6-dihydroxybenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110322", "l": "Formation of Pol zeta complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74897", "l": "nitric oxide(in) => nitric oxide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33390", "l": "cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine <=> aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000511", "l": "H2A-H2B histone complex chaperone activity", "d": ["A histone chaperone that carries a H2A-H2B histone complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949580", "l": "F1Fo ATP synthase dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12357", "l": "D-mannose 6-phosphate => D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57313", "l": "H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine => cytidine 5'-diphosphoramidate + H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64067", "l": "(1R,2R)-pseudoephedrine + NAD(+) <=> (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69627", "l": "N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.916538309327947", "identifiers": [{"i": "GO:0016823", "l": "hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances", "d": ["Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17037", "l": "indole-3-ethanol + NADP(+) = H(+) + indole-3-acetaldehyde + NADPH", "d": []}, {"i": "EC:1.1.1.191", "l": "\"indole-3-acetaldehyde reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25549", "l": "(+)-copalyl diphosphate => abieta-8(14),12-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864453", "l": "TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers bind the ERBB2 gene promoter and recruit YY1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964284", "l": "BTK in active Gq-BTK complex is activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37578", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65681", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9656891", "l": "OPN1SW binds 11cRAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12494", "l": "D-methionine => L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41638", "l": "1-O-(1Z-alkenyl)-sn-glycerol + phosphate => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008454", "l": "alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788623", "l": "p-Y-STATs translocate to nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51786", "l": "deoxyhumulone + diphosphate => 4-prenylphlorisovalerophenone + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021949", "l": "MEF2C gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110218", "l": "Cleavage of uracil by TDG glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72166", "l": "chloride(out) + 2 Na(+)(out) + O-butanoyl-(R)-carnitine(out) <=> chloride(in) + 2 Na(+)(in) + O-butanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24461", "l": "H(+) + malonyl-[ACP] => acetyl-[ACP] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852716", "l": "Thrombin, ELANE cleave C5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14921", "l": "(indol-3-yl)acetate + UDP-alpha-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP", "d": []}, {"i": "EC:2.4.1.121", "l": "\"indole-3-acetate beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647660", "l": "GSDME (1-270) binds PIPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987007", "l": "p-STAT1 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38804", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483087", "l": "PI is exchanged with PC by PITPNB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19015", "l": "dTDP + H(+) + phosphate => dTTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12527", "l": "L-pipecolate + NADP(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39204", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADPH => NADP(+) + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034574", "l": "didemethylisoproturon dehydrogenase activity", "d": ["Catalysis of the reaction: didemethylisoproturon + H2O = 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349455", "l": "Phosphorylation of MDM4 by ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20465", "l": "[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62897", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210444", "l": "L-Glutamate loading of synaptic vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44140", "l": "CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate = acetyl-CoA + CO2 + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39270", "l": "(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714691", "l": "RAC3 binds ER effectors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018474", "l": "2-carboxybenzaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 2-carboxybenzaldehyde + NAD+ + H2O = NADH + 2 H+ + phthalate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047461", "l": "(+)-delta-cadinene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (+)-delta-cadinene."]}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0038054", "l": "G protein-coupled estrogen receptor activity", "d": ["Combining with estrogen and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804596", "l": "APAF1:CYCS binds APIP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.242", "l": "\"3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35925", "l": "3''-deamino-3''-hydroxykanamycin B + H(+) + UDP => neamine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22146", "l": "D-threo-isocitrate => cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604722", "l": "Activation of proMMP9 by proteases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70566", "l": "H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63437", "l": "1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000319", "l": "BORA binds PLK1 and AURKA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10836", "l": "NADPH + O2 + questin = demethylsulochrin + NADP(+)", "d": []}, {"i": "EC:1.14.13.43", "l": "\"questin monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58744", "l": "H2O + N(7)-methyl-GTP = diphosphate + H(+) + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57560", "l": "(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.161", "l": "\"nepetalactol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64224", "l": "AH2 + O2 + uridine(34) in tRNA = 5-hydroxyuridine(34) in tRNA + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55567", "l": "4-hydroxytryptamine + ATP <=> 4-hydoxytryptamine 4-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73004", "l": "anthranilate + 2 ATP + L-tryptophan => (R)-benzodiazepinedione + 2 AMP + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196773", "l": "COASY phosphorylates DP-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47104", "l": "5,10-methylenetetrahydromethanopterin + glycine + H2O = 5,6,7,8-tetrahydromethanopterin + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60823", "l": "H2O + NADPH <=> adenosine 2',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018747", "l": "RHOQ GEFs activate RHOQ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38744", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22019", "l": "[glutaredoxin]-dithiol + arsenate + glutathione + H(+) <=> arsenite + glutathionyl-S-S-[glutaredoxin] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61929", "l": "(R)-miconazole(in) + ATP + H2O => (R)-miconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33427", "l": "(S)-malyl alpha-D-glucosaminide + L-cysteine = bacillithiol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71423", "l": "3,3',5-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) = 3,3',5-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18063", "l": "methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin => 5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35662", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose <=> GDP + H(+) + mannosylinositol phosphorylphytoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14475", "l": "a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH => a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036283", "l": "Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the terminal GlcA residue (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25485", "l": "(2E)-geranyl diphosphate => (1S,4R)-camphene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.20", "l": "\"DNA-3-methyladenine glycosylase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443774", "l": "Trans-homodimerization of Neurofascin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21867", "l": "an S-(2-hydroxyacyl)glutathione + H2O <=> a 2-hydroxy carboxylate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14071", "l": "5-dehydro-D-fructose + H(+) + NADPH => D-fructose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34023", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) = (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67498", "l": "3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end CoA-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868236", "l": "BAR domain proteins recruit dynamin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29350", "l": "2 H(+)(in) + orotate(in) <=> 2 H(+)(out) + orotate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797553", "l": "Protein 4.1 binds CASK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44044", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58503", "l": "glycine betaine + H(+) + NADH + O2 <=> glyoxylate + H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031808", "l": "H2 histamine receptor binding", "d": ["Binding to a H2 histamine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.147", "l": "\"ADP-specific glucose/glucosamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30230", "l": "dimethyl sulfide + 2 Fe(III)-[cytochrome c2] + H2O <=> dimethyl sulfoxide + 2 Fe(II)-[cytochrome c2] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53551", "l": "prostaglandin J2 <=> Delta(12)-prostaglandin J2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937989", "l": "RUNX1 binds PRC1 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10372", "l": "CoA + NAD(+) + phenylglyoxylate = benzoyl-CoA + CO2 + NADH", "d": []}, {"i": "EC:1.2.1.58", "l": "\"phenylglyoxylate dehydrogenase (acylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50511", "l": "acetyl-CoA + N-terminal L-valyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015220", "l": "choline transmembrane transporter activity", "d": ["Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983299", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428609", "l": "Type I Na+-coupled phosphate co-transport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37469", "l": "1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP => 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140831", "l": "L-asparagine, sodium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-asparagine(out) + Na+(out) = H+(out) + L-asparagine(in) + Na+(in)."]}, {"i": "RHEA:71131", "l": "H(+)(in) + L-asparagine(out) + Na(+)(out) = H(+)(out) + L-asparagine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201603", "l": "Caspase-mediated cleavage of PKC theta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27979", "l": "GDP-alpha-D-mannose + H2O => alpha-D-mannose 1-phosphate + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18468", "l": "L-dopa + O2 <=> 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47944", "l": "(2E)-geranyl diphosphate + H2O = (2E)-geranyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61187", "l": "quercitrin + UDP-beta-L-rhamnose <=> H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53439", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371582", "l": "HSBP1 binds HSF1 trimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12471", "l": "avenacoside A + H2O <=> 26-desgluco-avenacoside A + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391158", "l": "SIRP alpha binds CD47 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850831", "l": "KLK5 cleaves and activates KLK8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66053", "l": "indole-3-pyruvate + L-kynurenine => H2O + kynurenate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450550", "l": "PKCalpha phosphorylates HuR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33180", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69660", "l": "H2O + kaempferol 3-O-beta-D-glucoside => beta-D-glucose + kaempferol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810076", "l": "DDO oxidizes D-Asp to OA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37436", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate => a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43285", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73225", "l": "(3S)-citramalate(out) + sulfate(in) => (3S)-citramalate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57905", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40746", "l": "(20S)-ginsenoside Rd + 2 H2O <=> (20S)-ginsenoside C-K + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192061", "l": "CYP46A1 24-hydroxylates CHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39419", "l": "3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21045", "l": "24-methylidenelophenol + S-adenosyl-L-methionine => (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73676", "l": "ADP(out) + dAMP(in) + H(+)(out) => ADP(in) + dAMP(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55962", "l": "4-(trimethylamino)butanoyl-CoA + AMP + diphosphate => 4-(trimethylamino)butanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12713", "l": "a nucleoside 5'-phosphate + ATP = a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)", "d": []}, {"i": "EC:2.7.6.4", "l": "\"nucleotide diphosphokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226012", "l": "Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607721", "l": "Activation of NIK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49014", "l": "aurachin C epoxide + H2O + NAD(+) => aurachin C + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879770", "l": "Expression of DEC2 (BHLHE41, BHLHB3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14012", "l": "2 dimethylallyl diphosphate <=> (R,R)-chrysanthemyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30001", "l": "ADP + H(+) + phosphate + spermidine(in) => ATP + H2O + spermidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173631", "l": "Activation of C1s (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209151", "l": "miR-24 binds p16INK4A and p14ARF mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16010", "l": "ATP + formate => ADP + formyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944240", "l": "Association of procollagen type III (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40404", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74511", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B = aspoquinolone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34981", "l": "H(+)(out) => H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857555", "l": "EGFR phosphorylates GPNMB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047297", "l": "asparagine-oxo-acid transaminase activity", "d": ["Catalysis of the reaction: a 2-oxo acid + L-asparagine = an amino acid + 2-oxosuccinamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4332359", "l": "Active calmodulin binds CAMK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197770", "l": "STAB1 (FEEL-1) binds ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800490", "l": "ATM phosphorylates PIDD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429694", "l": "CERT1-2 dissociates from the endoplasmic reticulum (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399930", "l": "Activation of PAK by Rac1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34507", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate = N,N-diacetyllegionaminate + phosphate", "d": []}, {"i": "EC:2.5.1.101", "l": "\"N,N'-diacetyllegionaminate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15391", "l": "3',5'-cyclic AMP + diphosphate => ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306876", "l": "NLRP3 activation by small molecules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11015", "l": "H2O + L-tryptophanamide <=> L-tryptophan + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46515", "l": "an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36151", "l": "(E)-cinnamyl alcohol + acetyl-CoA = (E)-cinnamyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73007", "l": "D-arabinose 5-phosphate = D-glyceraldehyde 3-phosphate + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40655", "l": "(R)-malate + succinyl-CoA = (R)-malyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69299", "l": "CDT1 binds geminin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18880", "l": "myo-inositol + S-adenosyl-L-methionine <=> 1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19095", "l": "12,18-didecarboxysiroheme + 2 CO2 => 2 H(+) + siroheme", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750226", "l": "NLRC5 binds IKBKB and CHUK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867041", "l": "EGFR phosphorylates EPS15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42859", "l": "1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44905", "l": "alpha-D-glucose 6-phosphate + H2O => alpha-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42345", "l": "H(+) + NADH + O2 + p-cumate => (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12049", "l": "3-oxoadipate + succinyl-CoA => 3-oxoadipyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141341", "l": "SMOX-3 oxidises SPN to SPM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24530", "l": "H(+) + methylglyoxal + NADH => (R)-lactaldehyde + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692550", "l": "Viral inhibitor of caspase-8 activation (UL36) binds caspase-8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177942", "l": "EGFR binds EGF ligand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58673", "l": "D-glucuronate => aldehydo-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74660", "l": "N-acetyl-D-glucosamine + UTP => H(+) + N-acetyl-D-glucosamine 6-phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561072", "l": "OCT3 mediates renal uptake of organic cations (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420980", "l": "Activation of Ca permeable AMPA receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61887", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707523", "l": "Hemes bind to BACH1:MAFK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55575", "l": "4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine <=> 4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39324", "l": "(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68705", "l": "3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate) => 3alpha-hydroxyetiocholan-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55501", "l": "ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30930", "l": "2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60443", "l": "H2O + methyl acetate <=> acetate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18461", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}, {"i": "EC:2.3.1.67", "l": "\"1-alkylglycerophosphocholine O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951644", "l": "Release of mature NEDD8 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45024", "l": "cholesterol + H(+) + NADPH + O2 = 7-dehydrocholesterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29125", "l": "H2O(out) + nitrite(out) + ubiquinone-8(in) => nitrate(out) + ubiquinol-8(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53427", "l": "a fatty acyl-CoA + a sphingoid base <=> an N-acyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033284", "l": "NTRK2 promotes TIAM1 phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74309", "l": "12alpha-hydroxy-3-oxochola-4-en-24-oate + H(+) + NADH => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33321", "l": "a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22328", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59914", "l": "(E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH => (E)-4-hydroxynon-2-enal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52292", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399952", "l": "Phosphorylation of LIMK-1 by PAK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933526", "l": "Recruitment of caspase-8 and -10 to FADD complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "50.139203482381099", "identifiers": [{"i": "GO:0022832", "l": "voltage-gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29934", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP <=> ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-378952", "l": "Thyrotropin is a heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202222", "l": "Phosphorylation of PKC theta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34482", "l": "(1R,2R,3R)-prephytoene diphosphate <=> 15-cis-phytoene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867047", "l": "PTPN3 dephosphorylates EPS15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332363", "l": "Autophosphorylation and activation of CAMK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62048", "l": "an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36941", "l": "(9Z)-tetradecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65733", "l": "2-oxoglutarate + heptyl sulfate + O2 => CO2 + H(+) + heptanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39930", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35048", "l": "adenylyl-molybdopterin + H(+) + molybdate => AMP + H2O + Mo-molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72185", "l": "mRNA polyadenylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58005", "l": "(20S)-ginsenoside F2 + UDP-alpha-D-glucose => (20S)-ginsenoside Rd + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21925", "l": "3-dehydro-L-gulonate + NAD(+) => 2,3-dioxo-L-gulonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106335", "l": "tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity", "d": ["Catalysis of the reaction: carboxymethyluridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800298", "l": "HGF dimer binds MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62458", "l": "diphosphate + L-glutamyl-5'-AMP => ATP + H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11161", "l": "2-oxoglutarate + L-2,4-diaminobutanoate => L-aspartate 4-semialdehyde + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53548", "l": "prostaglandin J2 = Delta(12)-prostaglandin J2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39613", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+) => 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74565", "l": "aldosterone hemiacetal 18-beta-glucuronide + H(+) + UDP => aldosterone hemiacetal + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654409", "l": "Activated FGFR3 binds FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350651", "l": "Caspase-mediated cleavage of MASK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51843", "l": "2 Na(+)(out) + tauroallocholate(out) <=> 2 Na(+)(in) + tauroallocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25811", "l": "H2O + O2 + spermidine <=> 3-aminopropanal + H2O2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72478", "l": "cis-aconitate(in) + citrate(out) <=> cis-aconitate(out) + citrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25220", "l": "acetyl-CoA + serotonin <=> CoA + H(+) + N-acetylserotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51029", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => 7-chloroindole-3-pyruvate imine dimer + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60646", "l": "adenosine 3',5'-bisphosphate + androsterone 3alpha-sulfate + H(+) => 3'-phosphoadenylyl sulfate + androsterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.4.5", "l": "\"tetrachlorohydroquinone reductive dehalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.-.-", "l": "\"Transferring aldehyde or ketonic groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69647", "l": "H2O + quercetin 4'-O-beta-D-glucoside = beta-D-glucose + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57365", "l": "H2O + NADH => (6S)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28842", "l": "H(+)(out) + Zn(2+)(in) <=> H(+)(in) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57085", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0045569", "l": "TRAIL binding", "d": ["Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618093", "l": "ATP hydrolysis by HSP90 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202709", "l": "JAM2 dimerises (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199299", "l": "AKT phosphorylates FOXO transcription factors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25309", "l": "7,8-dihydroneopterin + phosphate <=> 7,8-dihydroneopterin 3'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433451", "l": "JAK2 binds to p-KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421836", "l": "trans-Golgi Network Derived Vesicle Uncoating (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70106", "l": "H(+) + o-quinone methide + penilactone D <=> penilactone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197187", "l": "ACS transforms to QUIN non-enzymatically (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483087", "l": "PI is exchanged with PC by PITPNB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15799", "l": "biliverdin IXalpha + H(+) + NADH => bilirubin IXalpha + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433410", "l": "SOCS1 as a regulator of KIT signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68627", "l": "phycoerythrobilin-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56346", "l": "a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP => a 7-hydroxyisoflavone + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429415", "l": "SYK binds to integrin alphaIIb beta3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0008865", "l": "fructokinase activity", "d": ["Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794523", "l": "SLC22A1 transports Cipro into renal cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39918", "l": "1-O-alkyl-sn-glycero-3-phosphate + H2O <=> 1-O-alkyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849435", "l": "PTPN1 dephosphorylates PTK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941312", "l": "TUT4,TUT7 oligouridylate mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222020", "l": "NUAK1 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68648", "l": "2 L-cysteine = H(+) + hydrogen sulfide + L-lanthionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072587", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity", "d": ["Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25846", "l": "(R)-carvone + H(+) + NADH => (1S,5R)-carveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656254", "l": "Defective OGG1 mutants show decreased binding to 8-oxoguanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429860", "l": "DCP1-DCP2 complex decaps mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35617", "l": "H(+) + methylglyoxal + NADH => hydroxyacetone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49941", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 => (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61513", "l": "malvidin + UDP-alpha-D-glucose => malvidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607722", "l": "Active NIK phosphorylates IKKA dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73222", "l": "L-xylopyranose(out) + 2 Na(+)(out) <=> L-xylopyranose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32945", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64202", "l": "a fatty acid + L-leucine => an N-(fatty acyl)-L-leucine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018808", "l": "RAC3 binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66698", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine => (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419157", "l": "5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10721", "l": "2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74051", "l": "D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48352", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67812", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35951", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate = diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate", "d": []}, {"i": "EC:2.5.1.105", "l": "\"7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668395", "l": "CHMP7 binds CC2D1B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14730", "l": "beta-D-fructose 1,6-bisphosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12399", "l": "dTDP-D-galactose + H2O + 2 NADP(+) <=> dTDP-D-galacturonate + 3 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62226", "l": "(E)-ascladiol + NADP(+) => H(+) + NADPH + neopatulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654623", "l": "Activated FGFR3 binds FRS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046175", "l": "Further sulfation on galactose residues produces KSPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20850", "l": "acetyl phosphate + CO2 + H2O2 => H(+) + O2 + phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390598", "l": "Myosin Binds ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41631", "l": "geranylgeranyl diphosphate + H2O <=> cyclooctat-9-en-7-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62580", "l": "ATP + D-cystine(out) + H2O = ADP + D-cystine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034611", "l": "oligoribonucleotidase activity", "d": ["Catalysis of the exonucleolytic cleavage of oligoribonucleotides to yield ribonucleoside 5'-phosphates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707523", "l": "Hemes bind to BACH1:MAFK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52200", "l": "1-aci-nitro-2-(phenyl)ethane + glutathione = (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74924", "l": "a (3R)-3-[(carboxymethyl)amino]fatty acid + H(+) + holo-[ACP] => a (2E)-enoyl-[ACP] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73529", "l": "TDP(in) + UTP(out) => TDP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097600", "l": "exoxylanase activity", "d": ["A xylanase activity that acts on one of the ends of a xylan polymer which does not contain side chains."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5617815", "l": "BBSome binds RAB3IP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36602", "l": "hydrogen sulfide + NAD(+) <=> NADH + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34897", "l": "ADP + H(+) + phosphate + selenite(in) => ATP + H2O + selenite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635859", "l": "GLI:SUFU dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473184", "l": "Follistatin (FST) binds Activin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44164", "l": "ATP + H2O = adenine + D-ribose 5-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53374", "l": "H(+) + NADH + uridine(17) in tRNA => 5,6-dihydrouridine(17) in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0008988", "l": "rRNA (adenine-N6-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63236", "l": "ATP + streptomycin = 6-O-adenylylstreptomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13517", "l": "ATP + dTMP = ADP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72061", "l": "glycochenodeoxycholate(in) + 2 Na(+)(in) => glycochenodeoxycholate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419426", "l": "Cannabinoid receptors can bind cannabinoids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38914", "l": "avenacoside B + H2O <=> 26-desgluco-avenacoside B + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56448", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209295", "l": "Phosphorylated DL/DIF dimer transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10274", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+) => a 1,2-diacyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64052", "l": "(13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine = CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23053", "l": "ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] => ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56712", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate", "d": []}, {"i": "EC:2.5.1.145", "l": "\"phosphatidylglycerol--prolipoprotein diacylglyceryl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549304", "l": "OCT3 mediates renal clearance of organic cations (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879459", "l": "F-actin capping protein is a heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.42", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41389", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33029", "l": "3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one => 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66596", "l": "O2 + 2 tyramine = 2 dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9725855", "l": "NR3C2 binds NR3C2 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14091", "l": "glyoxylate + L-glutamate => 2-oxoglutarate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762246", "l": "ANGPTL4 binds CDH11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74079", "l": "H(+) + menaquinone-4 + NADH = menaquinol-4 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220964", "l": "NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49109", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine => 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806629", "l": "Formation of tonofilament bundles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25876", "l": "L-aspartate + O2 = H2O2 + iminosuccinate", "d": []}, {"i": "EC:1.4.3.16", "l": "\"L-aspartate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451846", "l": "LFT binds to FT and DS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864569", "l": "WWOX binds TFAP2C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28402", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) = ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002170", "l": "high-affinity IgA receptor activity", "d": ["Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45887", "l": "12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11726", "l": "3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol => [thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35702", "l": "(S)-versiconol + NADP(+) <=> (2S-3S)-versiconal hemiacetal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77068", "l": "Activation of GT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031778", "l": "type 2 melanin-concentrating hormone receptor binding", "d": ["Binding to a type 2 melanin-concentrating hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54329", "l": "2 H(+) + hexadecanoyl-[ACP] + 2 NADPH => hexadecan-1-ol + holo-[ACP] + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685011", "l": "ATR activation at DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474266", "l": "Formation of collagen fibrils (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879594", "l": "SLCO4C1 mediates the transport of digoxin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675194", "l": "Activated MAPK phosphorylates RAF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21446", "l": "H(+) + NADH + trans-2-coumarate => 3-(2-hydroxyphenyl)propanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29470", "l": "H(+)(out) + K(+)(in) <=> H(+)(in) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627106", "l": "SMAC (DIABLO) forms dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46806", "l": "a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine => a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17768", "l": "(2R)-3-phospho-glyceroyl phosphate <=> (2R)-2,3-bisphosphoglycerate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11268", "l": "D-cysteine + H2O = H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": []}, {"i": "EC:4.4.1.15", "l": "\"D-cysteine desulfhydrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008521", "l": "acetyl-CoA transmembrane transporter activity", "d": ["Enables the transfer of acetyl-CoA from one side of a membrane to the other. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.-", "l": "\"In C-halide compounds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008966", "l": "phosphoglucosamine mutase activity", "d": ["Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22865", "l": "L-lysine => D-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378956", "l": "Luteinizing hormone is a heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45741", "l": "2-oxoglutarate + L-ectoine + O2 => 5-hydroxyectoine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694656", "l": "Spike trimer glycoside chains are extended (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14543", "l": "cholate + CoA + H(+) => choloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63270", "l": "1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030762", "l": "tetrahydrocolumbamine 2-O-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + H+ + tetrahydropalmatine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015231", "l": "5-formyltetrahydrofolate transmembrane transporter activity", "d": ["Enables the transfer of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32914", "l": "sn-glycerol 3-phosphocholine(out) <=> sn-glycerol 3-phosphocholine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40277", "l": "(2E)-hexadecenedioyl-CoA + H2O2 => hexadecanedioyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903794", "l": "cortisol binding", "d": ["Binding to cortisol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63535", "l": "angiotensin I + H2O <=> angiotensin-(1-9) + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54808", "l": "H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2 = H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700168", "l": "Active ALK phosphorylates IRS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701147", "l": "TRPV1 binds TRPV1 blockers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17520", "l": "H2O + N-(long-chain-fatty-acyl)-L-glutamate <=> a long-chain fatty acid + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44173", "l": "H2O + NAD(+) + tetradecanal => 2 H(+) + NADH + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693608", "l": "Initial resection of double-strand break ends (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388830", "l": "PI3K binds ICOS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21777", "l": "(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA => (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34018", "l": "ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 <=> ergosterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11770", "l": "5-phospho-alpha-D-ribose 1-diphosphate + anthranilate => diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9794523", "l": "SLC22A1 transports Cipro into renal cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173680", "l": "Activation of C5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102152", "l": "Delta12-linoleate epoxygenase activity", "d": ["Catalysis of the reaction: H+ + 1-palmitoyl-2-linoleoyl-phosphatidylcholine + NADPH + O2 <=> 1-palmitoyl-2-vernoloyl-phosphatidylcholine + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60734", "l": "2 H(+) + NADPH + perillate => H2O + NADP(+) + perillyl aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170674", "l": "Dissociation of the Gi alpha:G olf complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0051748", "l": "UTP-monosaccharide-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49718", "l": "3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+) => 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607023", "l": "factor IXa associates with cell membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877902", "l": "Activated AR binds RUNX2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66956", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose = alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.378", "l": "\"GDP-mannose:alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und alpha-1,4-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1362416", "l": "Frataxin binds iron (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392195", "l": "Gi activation by P2Y purinoceptor 12 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17773", "l": "ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)", "d": []}, {"i": "EC:6.1.1.16", "l": "\"cysteine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29670", "l": "H2O(in) <=> H2O(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66595", "l": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA <=> a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029473", "l": "Branching and elongation of mother and daughter filaments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51372", "l": "(9Z)-hexadecenoyl-CoA + glycine = CoA + H(+) + N-(9Z-hexadecenoyl)-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73800", "l": "SAICAR => AICAR + Fumarate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58778", "l": "H(+) + NADPH + pyridine-3-carbaldehyde => NADP(+) + pyridine 3-methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28457", "l": "N(6)-(D-fructosyl)-L-lysine(in) <=> N(6)-(D-fructosyl)-L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41279", "l": "H2O + N-octadecanoylsphing-4-enine = octadecanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047243", "l": "flavanone 7-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: a flavanone + UDP-D-glucose = a flavanone 7-O-beta-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34879", "l": "2 H2O + methyl 3-cyano-2-phenylpropanoate = 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.417", "l": "\"3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6795460", "l": "SGK1 phosphorylates MDM2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33856", "l": "an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose => a mannosylinositol-1-phosphophytoceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63928", "l": "an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36060", "l": "A + dihydrourocanate => AH2 + urocanate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0009784", "l": "transmembrane receptor histidine kinase activity", "d": ["Combining with a signal and transmitting the signal from one side of a membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43438", "l": "coproporphyrin III + 3 H2O2 => coproporphyrinogen III + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5665871", "l": "ADRM1 binds 26S proteasome (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63927", "l": "ATP + N(4)-acetylcytidine <=> ADP + H(+) + N(4)-acetylcytidine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48121", "l": "ganglioside GD3 + H2O => ganglioside GM3 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112510", "l": "IL6ST is tyrosine phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050217", "l": "propioin synthase activity", "d": ["Catalysis of the reaction: 4-hydroxyhexan-3-one = 2 propanal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47456", "l": "(3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+) = 3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11536", "l": "choline + H2O + 2 O2 = glycine betaine + H(+) + 2 H2O2", "d": []}, {"i": "EC:1.1.3.17", "l": "\"choline oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28646", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-zingiberene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070748", "l": "interleukin-35 receptor binding", "d": ["Binding to an interleukin-35 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18740", "l": "ATP + H2O + hydrogenselenide <=> AMP + 2 H(+) + phosphate + selenophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25889", "l": "dihydroxyacetone phosphate + iminosuccinate => H(+) + 2 H2O + phosphate + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17958", "l": "3-oxopropanoate => H2O + propynoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49597", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose => H(+) + N-acyl-D-galactosylsphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28647", "l": "acetophenone + 2 ATP + H2O + hydrogencarbonate = 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate", "d": []}, {"i": "EC:6.4.1.8", "l": "\"acetophenone carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17183", "l": "a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu => a long-chain fatty aldehyde + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428609", "l": "Type I Na+-coupled phosphate co-transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41997", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose => globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-167429", "l": "The receptor:G-protein complex  binds GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50448", "l": "AH2 + prostaglandin G3 = A + H2O + prostaglandin H3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46545", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28292", "l": "(5S,9S,10S)-drim-7-en-11-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52752", "l": "H2O + isomaltose = beta-D-glucose + D-glucose", "d": []}, {"i": "EC:3.2.1.205", "l": "\"isomaltose glucohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74885", "l": "GUCYs converts GTP to cGMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73460", "l": "5 H(+) + 2 O2 + protochlorophyllide a + 4 reduced [2Fe-2S]-[ferredoxin] => 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74786", "l": "tyramine(in) <=> tyramine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848864", "l": "PTK6 binds ARAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45062", "l": "(9Z)-octadecenoate + ethanolamine => H2O + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35706", "l": "1'-hydroxyversicolorone + H(+) + NADPH + O2 <=> (2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14452", "l": "chlorophyllide a + NADP(+) <=> 3,8-divinyl chlorophyllide a + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.5.3", "l": "\"formate dehydrogenase-N\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430308", "l": "PARVB interacts with Alpha-actinin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33452", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] => AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36480", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA => (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46800", "l": "H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:7.2.1.2", "l": "\"ferredoxin--NAD(+) oxidoreductase (Na(+)-transporting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20130", "l": "AMP + H2O => adenine + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64159", "l": "an N-(fatty acyl)-L-methionine + H2O <=> a fatty acid + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720473", "l": "Defective ALG3 does not add mannose to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28704", "l": "Cu(2+)(in) => Cu(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158357", "l": "factor XIIa binds SERPING1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851919", "l": "Activated MET binds GAB1 and GRB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851933", "l": "MET phosphorylates GAB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426489", "l": "RISC binds inexactly matching target RNAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390087", "l": "WTS binds to SAV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050637", "l": "lovastatin nonaketide synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H+ + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO2 + 9 CoA + dihydromonacolin L + 6 H2O + 11 NADP+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031721", "l": "hemoglobin alpha binding", "d": ["Binding to a hemoglobin alpha chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864595", "l": "TFAP2B homodimer binds YEATS4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73797", "l": "FAICAR => IMP + H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690669", "l": "CD22 binds itself to form homo-oligomers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047541", "l": "2-furoate-CoA ligase activity", "d": ["Catalysis of the reaction: 2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811427", "l": "COPI vesicle uncoating at the ER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32098", "l": "acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose <=> CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15244", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate <=> 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10767", "l": "(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 <=> (4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21744", "l": "S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:4.4.1.14", "l": "\"1-aminocyclopropane-1-carboxylate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61792", "l": "ATP + L-tryptophan = diphosphate + L-tryptophyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938887", "l": "PML binds RUNX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63773", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717374", "l": "SCN3A:SCN2B,4B transports Na+ from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20797", "l": "aldehydo-D-ribose => D-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27764", "l": "CMP + diphosphate + H(+) => CTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163489", "l": "phosphorylated HSL + H2O -> HSL + orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.1", "l": "\"DNA topoisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418200", "l": "SRC-1 bound to ARRB2 is not activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43921", "l": "(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15930", "l": "2 H(+) + 2 H2O + methylenediurea => CO2 + N-(hydroxymethyl)urea + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61821", "l": "3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose => epiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59670", "l": "D-cellohexaono-1,5-lactone + H2O2 => D-cellohexaose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22335", "l": "(3R)-citramalate <=> 2-methylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39671", "l": "(9Z)-hexadecenoyl-CoA + AH2 + O2 = (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21820", "l": "L-homocysteine + S-adenosyl-L-methionine = H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56672", "l": "dihydro-4-coumaroyl-CoA + NADP(+) = (E)-4-coumaroyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198314", "l": "DAG stimulates protein kinase C-delta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27328", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442749", "l": "CaMKK autophosphorylates in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65059", "l": "glycochenodeoxycholate + NADP(+) <=> 7-oxoglycolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73596", "l": "dCMP + H2O => dUMP + NH4+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41944", "l": "[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP", "d": []}, {"i": "EC:2.7.2.17", "l": "\"[amino-group carrier protein]-L-2-aminoadipate 6-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28234", "l": "L-glutamate 5-semialdehyde = (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28619", "l": "2-methylbutyronitrile + H(+) + NADPH + O2 => 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51819", "l": "ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out) <=> AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296045", "l": "Activation of Potassium transport channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192912", "l": "NP binds vRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51429", "l": "acetyl-CoA + aminomethylphosphonate => 2-N-acetamidomethylphosphonate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42470", "l": "2-oxopent-4-enoate + salicylate => 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.61", "l": "\"linolenate 9R-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875817", "l": "MET phosphorylates STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13827", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH => GDP-alpha-D-rhamnose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10976", "l": "H(+) + NADH + O2 + quinolin-2-ol = 5,6-dihydroquinoline-2,5,6-triol + NAD(+)", "d": []}, {"i": "EC:1.14.12.16", "l": "\"2-hydroxyquinoline 5,6-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18435", "l": "cyclohexanone + H2O2 + NH4(+) => cyclohexylamine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022625", "l": "MECP2 binds FOXG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444047", "l": "Receptor FFAR3 binds carboxylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16706", "l": "17alpha-estradiol + NADP(+) => estrone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25164", "l": "A + butanoyl-CoA = (2E)-butenoyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55848", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0048258", "l": "3-ketoglucose-reductase activity", "d": ["Catalysis of the reaction: NADP+ + 3-dehydro-alpha-D-glucose = NADPH + alpha-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45919", "l": "12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0031492", "l": "nucleosomal DNA binding", "d": ["Binding to the DNA portion of a nucleosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75846", "l": "ergothioneine(out) + Na(+)(out) <=> ergothioneine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42785", "l": "adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59092", "l": "[(1->3)-alpha-D-glucosyl](n) + sucrose = [(1->3)-alpha-D-glucosyl](n+1) + D-fructose", "d": []}, {"i": "EC:2.4.1.372", "l": "\"mutansucrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9633044", "l": "ESR binds STRN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061662", "l": "ISG15 ligase activity", "d": ["Catalysis of the transfer of a ISG15 to a substrate protein via the reaction X-ISG15 + S = X + S-ISG15, where X is either an E2 or E3 enzyme, the X-ISG15 linkage is a thioester bond, and the S-ISG15 linkage is an isopeptide bond between the C-terminal amino acid of ISG15 and the epsilon-amino group of lysine residues in the substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24881", "l": "A + L-sorbopyranose <=> 1-dehydro-L-sorbose + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163090", "l": "Elongation Of The Telomeric Chromosome End (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072555", "l": "17-beta-ketosteroid reductase activity", "d": ["Catalysis of the reaction: a 17-beta-ketosteroid + NADPH + H+ = a 17-beta-hydroxysteroid + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807872", "l": "Active ARF recruits coatomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40782", "l": "2-aminopentanenitrile + H(+) + 2 H2O <=> L-2-aminopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392143", "l": "NO binds to Guanylate Cyclase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36741", "l": "CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine => heptadecasphing-4-enine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61749", "l": "rubusoside + UDP-alpha-D-glucose => H(+) + stevioside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37064", "l": "2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0086007", "l": "voltage-gated calcium channel activity involved in cardiac muscle cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176452", "l": "Degradation of ubiquitinated SMAD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62742", "l": "1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2 => (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19975", "l": "H(+) + S-methyl-5'-thioadenosine + spermine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31534", "l": "2-oxoglutarate + L-arginine + O2 <=> CO2 + N(omega)-hydroxy-L-arginine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27869", "l": "(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O <=> (R)-glycerate + alpha-D-mannose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031886", "l": "type 1 member 3 taste receptor binding", "d": ["Binding to a type 1 member 3 taste receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168951", "l": "TLR1:TLR2 is recruited to ligand:CD14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.233323709485049", "identifiers": [{"i": "GO:0005230", "l": "extracellular ligand-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62040", "l": "H2O + N-(octanoyl)-sphing-4-enine-1-phosphate = N-octanoylsphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30589", "l": "2-demethylmenaquinone-8 + dimethyl sulfide + H2O => 2-demethylmenaquinol-8 + dimethyl sulfoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45302", "l": "an N-acyl-sphingoid base + H(+) + phosphocholine => an N-(acyl)-sphingosylphosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75536", "l": "FMNH2 + N-acetyl-S-methyl-L-cysteine + O2 => (R)-N-acetyl-S-methyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45157", "l": "3-oxopropanoyl-CoA + H2O => 3-oxopropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429845", "l": "5' to 3' exoribonuclease hydrolyzes decapped mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71303", "l": "RPE dimers isomerise RU5P to XY5P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50684", "l": "H2O + N(5)-phenyl-L-glutamine = aniline + H(+) + L-glutamate", "d": []}, {"i": "EC:3.5.1.123", "l": "\"gamma-glutamylanilide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66762", "l": "ADP + H(+) + kainate(out) + phosphate => ATP + H2O + kainate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27641", "l": "phosphate + xanthosine <=> alpha-D-ribose 1-phosphate + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362549", "l": "Hh-Np traffics to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879562", "l": "SLCO2B1 has a narrow substrate specificity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164527", "l": "Annealing of 3'-end of unwound transfer RNA primer with genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68213", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoylglycerol => 1,2-dihexanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24312", "l": "L-lysyl-[cytochrome c] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.59", "l": "\"[cytochrome c]-lysine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30547", "l": "(3S)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.179166783752436", "identifiers": [{"i": "GO:0005217", "l": "intracellular ligand-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61549", "l": "ent-kaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ent-7alpha-hydroxykaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390663", "l": "ADRA2A,B,C bind ADR,NAd (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18349", "l": "ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)", "d": []}, {"i": "EC:6.1.1.23", "l": "\"aspartate--tRNA(Asn) ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20951", "l": "3-sulfopyruvate + H(+) <=> CO2 + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682826", "l": "LGI1 binds ADAM11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46874", "l": "a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50485", "l": "acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40151", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58665", "l": "(S)-2-hydroxyglutarate + a quinone => 2-oxoglutarate + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32847", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol = a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645126", "l": "Activators bind STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28120", "l": "D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP => di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63468", "l": "all-trans-octaprenol + ATP = ADP + all-trans-octaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23278", "l": "3-methyl-2-oxobutanoate + formaldehyde => 2-dehydropantoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61897", "l": "betaenone C => betaenone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29080", "l": "(R)-lactate + ubiquinone-8 => pyruvate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40363", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-688137", "l": "RIP2 is K63 polyubiquitinated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32598", "l": "7-isopropyl-4-methyloxepan-2-one + H2O <=> 6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051997", "l": "2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity", "d": ["Catalysis of the reaction: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H imidazole-5-carboxylate + H+ = S-allantoin + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75079", "l": "Formation of AT-AC C complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665871", "l": "ADRM1 binds 26S proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37666", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50774", "l": "acetaldehyde + H(+) + H2O2 + nitrite => H2O + nitroethane + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43839", "l": "cholesterol + H(+) + NADPH + O2 <=> 26-hydroxycholesterol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54274", "l": "(3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9749253", "l": "Formation of MCM2-7 complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66821", "l": "ATP + H2O + Mn(2+)(in) => ADP + H(+) + Mn(2+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.122", "l": "\"L-cysteate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55162", "l": "coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849085", "l": "ARHGAP35 binds RHOA:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60683", "l": "(+)-artemisinic aldehyde + H2O + NADP(+) <=> (+)-artemisinate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27420", "l": "2 Fe(III)-[cytochrome] + H2O + nicotinate <=> 6-hydroxynicotinate + 2 Fe(II)-[cytochrome] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32440", "l": "(+)-epi-isozizaene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => albaflavenone + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63496", "l": "4-nitrobenzaldehyde + H(+) + NADPH = 4-nitrobenzyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50104", "l": "taurine + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10680", "l": "L-proline = D-proline", "d": []}, {"i": "EC:5.1.1.4", "l": "\"proline racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682983", "l": "ATM phosphorylates WHSC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41847", "l": "(3R)-hydroxyoctanoyl-[ACP] <=> (2E)-octenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27712", "l": "ADP + GMP + H(+) => ATP + guanosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57012", "l": "a menaquinone + H2O + sulfite = a menaquinol + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635842", "l": "ULK3 phosphorylates GLI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140463", "l": "chromatin-protein adaptor activity", "d": ["The binding activity of a molecule that brings together a protein or a protein complex with a nucleosome, to establish or maintain the chromatin localization of the protein, or protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53274", "l": "keto-D-tagaturonate => 5-dehydro-L-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43252", "l": "1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662613", "l": "MT3 exchanges zinc for copper (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36172", "l": "a 1-acylglycerone 3-phosphate + a long chain fatty alcohol => 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19273", "l": "H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate = N-acetylneuraminate + phosphate", "d": []}, {"i": "EC:2.5.1.56", "l": "\"N-acetylneuraminate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018747", "l": "RHOQ GEFs activate RHOQ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72255", "l": "dopamine + S-adenosyl-L-methionine = 3-methoxytyramine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68751", "l": "alpha-D-glucose 1-phosphate + O-phospho-L-seryl-[protein] <=> alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73003", "l": "anthranilate + 2 ATP + L-tryptophan = (R)-benzodiazepinedione + 2 AMP + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442387", "l": "ZIP8 mediates zinc influx into cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12220", "l": "H2O + L-leucine + NAD(+) = 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.9", "l": "\"leucine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50468", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH = 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37988", "l": "delta-tocopherol => 2-methyl-6-phytyl-1,4-benzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28451", "l": "N(6)-(D-psicosyl)-L-lysine(in) => N(6)-(D-psicosyl)-L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47987", "l": "H2O + presqualene diphosphate <=> diphosphate + hydroxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848713", "l": "PTK6 binds BCAR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29498", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> beta-eudesmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014296", "l": "RAC2 GEFs activate RAC2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.74", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67673", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61131", "l": "O2 + quercetin + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869580", "l": "DEK binds TFAP2A homodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847880", "l": "CYTH proteins bind ARF1:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022871", "l": "protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2197698", "l": "Src phosphorylate WASP,N-WASP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68611", "l": "Formation of ORC(1-5) complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043781", "l": "cobalt-factor II C20-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20879", "l": "(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.20.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47993", "l": "H(+)(in) + NAD(+) + NADPH => H(+)(out) + NADH + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9674531", "l": "AAMP binds EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50873", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 => (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351901", "l": "Caspase-mediated cleavage of MST3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21937", "l": "carbamoyl phosphate + putrescine => H(+) + N-carbamoylputrescine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61559", "l": "gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810392", "l": "TMEM55B translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610722", "l": "CK1 phosphorylates p-GLI3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41531", "l": "(2E)-octenoyl-[ACP] + H(+) + NADH <=> NAD(+) + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13725", "l": "acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": []}, {"i": "EC:2.3.1.157", "l": "\"glucosamine-1-phosphate N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473594", "l": "Collagen type II degradation by MMP15 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22408", "l": "dimethylallyl diphosphate + isopentenyl diphosphate = (2E)-geranyl diphosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.1", "l": "\"dimethylallyltranstransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60812", "l": "2-oxoglutarate + gibberellin A12 aldehyde + O2 = CO2 + gibberellin A12 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0003755", "l": "peptidyl-prolyl cis-trans isomerase activity", "d": ["Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71155", "l": "(E)-caffeoylpyruvate + H2O = (E)-caffeate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31756", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + H2O => 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38261", "l": "glyoxylate + propanoyl-CoA => (2R,3S)-beta-methylmalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9623384", "l": "α1-agonists bind ADRA1A,B,D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430308", "l": "PARVB interacts with Alpha-actinin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102599", "l": "cytochrome P450 dependent beta-amyrin 12,13beta-epoxidase activity", "d": ["Catalysis of the reaction: beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-beta-amyrin + H2O + NAD(P)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21117", "l": "D-maltose + phosphate => beta-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39745", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432054", "l": "Aquaporin-1 passively transports water out of cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65223", "l": "(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+) <=> catechol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655252", "l": "Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102504", "l": "luteolinidin 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: luteolinidin + UDP-alpha-D-glucose <=> luteolinidin 5-O-glucoside + UDP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73482", "l": "D-histidine(in) + H(+)(in) + L-ornithine(out) <=> D-histidine(out) + H(+)(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40811", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163798", "l": "Furin cleaves pro-protein Z to protein Z (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48277", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17476", "l": "GTP + H2O <=> 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754130", "l": "CDK4 inhibitors bind CDK4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46122", "l": "4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45942", "l": "4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30795", "l": "2-oxoadipate + CoA + NAD(+) = CO2 + glutaryl-CoA + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16656", "l": "D-gluconate + NADP(+) <=> 2-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047233", "l": "N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-beta-D-galactosaminyl-1,4-(N-acetyl-alpha-neuraminyl-2,3)-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5226979", "l": "ADD1:ADD2 binds DMTN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57290", "l": "a guanosine in RNA + H(+) + lactate => an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68196", "l": "1,2-dihexanoylglycerol + tetradecanoyl-CoA = 1,2-dihexanoyl-3-tetradecanoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72381", "l": "chloride(in) + iodide(out) => chloride(out) + iodide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433454", "l": "Phosphorylation of GAB2 by SFKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65598", "l": "4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33942", "l": "H(+) + L-arginine + NADH + O2 <=> H2O + N(omega)-hydroxy-L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34346", "l": "(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42208", "l": "a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2 = a (Z)-omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.237", "l": "\"aliphatic glucosinolate S-oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082356", "l": "HSF1-mediated gene expression (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791173", "l": "Expression of ATF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651773", "l": "LIG1 binds POLB at long-patch BER site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938815", "l": "RNF152 polyubiquitinates RRAGA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.213", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34698", "l": "(2E,6E)-farnesyl diphosphate <=> Delta(6)-protoilludene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.9148261867131", "identifiers": [{"i": "GO:0140101", "l": "catalytic activity, acting on a tRNA", "d": ["Catalytic activity that acts to modify a tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213201", "l": "Formation of collagen fibres (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16483", "l": "3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine => 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75376", "l": "inosine(in) => inosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395768", "l": "LPL hydrolyses TGs from mature CMs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74218", "l": "H2O + L-seryl-tRNA(Lys) <=> L-serine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443774", "l": "Trans-homodimerization of Neurofascin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62831", "l": "GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42122", "l": "5alpha-androstan-3,17-dione + H(+) + NADPH => 17beta-hydroxy-5alpha-androstan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49934", "l": "(2E,5Z)-octadienoyl-CoA => (3E,5Z)-octadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052758", "l": "coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity", "d": ["Catalysis of the reaction: 2,4,6-trinitrophenol + H- = 2,4,6-trinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65890", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate => 2-oxoglutarate + 3-hydroxy-L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19959", "l": "2 9-riburonosylhypoxanthine + 2 H(+) => 2 5'-dehydroinosine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654167", "l": "Activated FGFR1 binds PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660662", "l": "ASC binds Caspase-8 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25335", "l": "H2O + L-cysteinyl-tRNA(Cys) => H(+) + L-cysteine + tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41650", "l": "ADP + N(5)-phenyl-L-glutamine + phosphate => aniline + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64065", "l": "(1R,2R)-pseudoephedrine + NAD(+) => (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54142", "l": "5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(49) in tRNA precursor + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34874", "l": "methanol(out) <=> methanol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21230", "l": "beta-maltose => alpha-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696457", "l": "BDH2 dehydrogenates 3HBA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-171106", "l": "LDLR:LDL complex => LDLR + LDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65342", "l": "CoA + O-acetyl-L-threonyl-[protein] => acetyl-CoA + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865275", "l": "PDGF-BB clevage by Furin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168136", "l": "NOTCH3 binds DLL4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63362", "l": "(S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2 => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141409", "l": "Mad1 binds kinetochore (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40874", "l": "(9Z)-octadecenoyl-CoA + FAD + H(+) <=> (2E,9Z)-octadecadienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070038", "l": "rRNA (pseudouridine-N3-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40689", "l": "1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9794008", "l": "LUBAC binds CFLAR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39088", "l": "decanedioyl-CoA + O2 => (2E)-decenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222704", "l": "KatG reduces H2O2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10615", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31777", "l": "11-cis-retinol + H(+) + hexadecanoate => all-trans-retinyl hexadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52494", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24948", "l": "3-hydroxy-3-methylglutarate + malonyl-CoA = (3S)-hydroxy-3-methylglutaryl-CoA + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61104", "l": "(2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20275", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046935", "l": "1-phosphatidylinositol-3-kinase regulator activity", "d": ["Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15580", "l": "H2O + uridine <=> D-ribose + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16703", "l": "estrone + H(+) + NADH => 17alpha-estradiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52284", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61329", "l": "O2 + parthenolide + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45475", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24805", "l": "(2S)-2-acetolactate + thiamine diphosphate = 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33062", "l": "(R)-dihydrolipoamide + NAD(+) <=> (R)-lipoamide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59391", "l": "a fatty acid ester + H2O <=> a fatty acid + an aliphatic alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686578", "l": "Activated ATM phosphorylates ABL1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450488", "l": "BRF1 Complex recruits RNA degradation activities (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71994", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> (-)-astellatene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50385", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline => 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51676", "l": "[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038048", "l": "dynorphin receptor activity", "d": ["Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42375", "l": "16-methoxytabersonine + H2O <=> (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32289", "l": "(2S)-2-isopropylmalate => (2R,3S)-3-isopropylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198508", "l": "MDH1 oxidizes MAL to OA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.5", "l": "\"hydroxymethylglutaryl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032018", "l": "2-methylbutanol:NADP oxidoreductase activity", "d": ["Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426160", "l": "SREBP1A,1C,2 binds the ACACA promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46775", "l": "1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727284", "l": "9b forms a homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66849", "l": "2 Cu(2+) + NADH => 2 Cu(+) + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985594", "l": "MYO9B inactivates RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004475", "l": "mannose-1-phosphate guanylyltransferase (GTP) activity", "d": ["Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660665", "l": "Caspase-8 binds MALT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20605", "l": "cytosine + H(+) + H2O = NH4(+) + uracil", "d": []}, {"i": "EC:3.5.4.1", "l": "\"cytosine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53784", "l": "beta-muricholate + deoxycholoyl-CoA = beta-muricholoyl-CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051992", "l": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine + di-trans,poly-cis-undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30088", "l": "(S)-2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34903", "l": "4 glutathione + 2 H(+) + selenite = glutathione disulfide + 3 H2O + selenodiglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16786", "l": "an adenosine in tRNA + S-adenosyl-L-methionine => an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67025", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30755", "l": "ATP + carbamate = ADP + carbamoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43970", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756414", "l": "SNAI1 binds the CDH1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57732", "l": "A + all-trans-7,8-dihydroretinol = AH2 + all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698677", "l": "HCMV UL36 binds MLKL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807826", "l": "LDHAL6B reduces PYR to LACT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25881", "l": "2 L-dopa + O2 => 2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28347", "l": "7,8-dihydroneopterin 3'-triphosphate => 7,8-dihydromonapterin 3'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58449", "l": "N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626220", "l": "C2CD3 binds the mother centriole (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55300", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008735", "l": "L-carnitine CoA-transferase activity", "d": ["Catalysis of the reactions: (E)-4-(trimethylammonio)but-2-enoyl-CoA + L-carnitine = (E)-4-(trimethylammonio)but-2-enoate + L-carnitinyl-CoA and 4-trimethylammoniobutanoyl-CoA + L-carnitine = 4-trimethylammoniobutanoate + L-carnitinyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109817", "l": "GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141423", "l": "Binding of the MCC complex to the APC/C complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50252", "l": "an acyl-CoA + H(+) + malonyl-CoA = a 3-oxoacyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791071", "l": "Expression of PLA2G4B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25509", "l": "(2E)-geranyl diphosphate => (1S,5S)-sabinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218832", "l": "CDC42:GTP binds PAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48732", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O = [CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine", "d": []}, {"i": "EC:3.13.1.6", "l": "\"[CysO sulfur-carrier protein]-S-L-cysteine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57068", "l": "3-oxoisoapionate + ATP = 3-oxoisoapionate 4-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.231", "l": "\"3-oxoisoapionate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209828", "l": "Tryptophan is hydroxylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2025890", "l": "Calcineurin binds NFATC1,2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015095", "l": "magnesium ion transmembrane transporter activity", "d": ["Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950342", "l": "EBI3:CANX binds IL27 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46570", "l": "5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28435", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + tetradecanoyl-[ACP] => ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25851", "l": "(1S,5S)-carveol + NAD(+) <=> (S)-carvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174963", "l": "NAT1 acetylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43288", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3341294", "l": "Superoxide reduces cytochrome c (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851352", "l": "CCR8 binds CCL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47132", "l": "11-cis-retinal + H2O + NAD(+) = 11-cis-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382053", "l": "Translocation of PDGF from ER to Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008441", "l": "3'(2'),5'-bisphosphate nucleotidase activity", "d": ["Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210444", "l": "L-Glutamate loading of synaptic vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57849", "l": "2-oxoglutarate + O2 + scopoletin => CO2 + fraxetin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805811", "l": "Release of SEPT4 from mitochondria (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396009", "l": "STING binds c-di-GMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58619", "l": "N-octanoyl-(2S)-hydroxyglycine <=> glyoxylate + octanamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60071", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 <=> 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15612", "l": "ATP + D-ribose 5-phosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13936", "l": "all-trans-retinyl hexadecanoate + H2O <=> all-trans-retinol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33922", "l": "H(+) + lanosterol + NADPH <=> 24,25-dihydrolanosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21955", "l": "5alpha-pregnane-3,20-dione + NADP(+) <=> H(+) + NADPH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63013", "l": "(2E,6E)-farnesyl diphosphate + orsellinate => diphosphate + ilicicolinate B", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050617", "l": "15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63024", "l": "(13Z)-docosenamide + H2O = (13Z)-docosenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805276", "l": "CDK5 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69572", "l": "dIMP + inosine = 2'-deoxyinosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40213", "l": "3-oxotetradecanedioyl-CoA + H(+) + NADH => (3S)-hydroxytetradecanedioyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186786", "l": "Autophosphorylation of PDGF beta receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35102", "l": "fusidate(in) + H(+)(out) <=> fusidate(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72086", "l": "ADP-alpha-D-ribose 1'',2''-cyclic phosphate + H2O <=> ADP-alpha-D-ribose 1''-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031801", "l": "type 4 metabotropic glutamate receptor binding", "d": ["Binding to a type 4 metabotropic glutamate receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018637", "l": "1-hydroxy-2-naphthoate hydroxylase activity", "d": ["Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 + NADPH + 2 H+ = NADP+ + H2O + CO2 + 1,2-dihydroxynaphthalene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27660", "l": "2-deoxy-D-ribose 5-phosphate => 2-deoxy-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53502", "l": "1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047479", "l": "trypanothione synthase activity", "d": ["Catalysis of the reaction: reduced glutathione + glutathionylspermidine + ATP = trypanothione + ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35974", "l": "12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate <=> diphosphate + fumitremorgin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39640", "l": "(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA => (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55230", "l": "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9006850", "l": "IL21 receptor JAK phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018785", "l": "haloacetate dehalogenase activity", "d": ["Catalysis of the reaction: haloacetate + H2O = glycolate + halide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507868", "l": "Aquaporins passively transport water into cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54980", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose = [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32099", "l": "S-adenosyl-L-methionine + TRIBOA beta-D-glucoside = DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.241", "l": "\"2,4,7-trihydroxy-1,4-benzoxazin-3-one-glucoside 7-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42277", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] => (4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51601", "l": "2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23166", "l": "a flavonol 7-O-beta-D-glucoside + H(+) + UDP => a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018518", "l": "5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity", "d": ["Catalysis of the reaction: 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD+ = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035244", "l": "protein-arginine C-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein. This modification has been detected in anaerobic bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72325", "l": "3 Na(+)(in) + thiosulfate(in) => 3 Na(+)(out) + thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204169", "l": "PDP dephosphorylates p-lipo-PDH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.47", "l": "\"gingipain K\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73023", "l": "pregnenolone sulfate(out) = pregnenolone sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42863", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + H2O <=> 1,2-dioctanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44460", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol = a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762345", "l": "PREDN:ALB dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33235", "l": "2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 = 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)", "d": []}, {"i": "EC:1.14.13.81", "l": "\"magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17682", "l": "3-hydroxy-2-methylpropanoate + NAD(+) => 2-methyl-3-oxopropanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55831", "l": "cortisol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24753", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite => 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416683", "l": "SEMA3E binds to PLXND1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400204", "l": "PPARA binds RXRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008043", "l": "MAPK8 phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14424", "l": "H2O + N(2)-benzoyl-D-arginine-4-nitroanilide <=> 4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18665", "l": "(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) = (2R)-3-phosphoglycerate + [phosphate](n+1)", "d": []}, {"i": "EC:2.7.4.17", "l": "\"3-phosphoglyceroyl-phosphate--polyphosphate phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67760", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65362", "l": "a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022065", "l": "DSPGs are secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47226", "l": "16alpha-hydroxydehydroepiandrosterone 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dehydroepiandrosterone 3-sulfate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855047", "l": "Hydrolysis of internal thioester in C4b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.19", "l": "\"glutamyl endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785895", "l": "Expression of IL4, IL13-upregulated extracellular proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939670", "l": "RUNX2:CBFB binds the ITGA5 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43624", "l": "2-aminomalonate semialdehyde + H(+) = aminoacetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11481", "l": "3-hydroxybenzoate + H(+) + NADPH + O2 => 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141367", "l": "Myristoylation of tBID by NMT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17659", "l": "a 1-acylglycerone 3-phosphate + CoA => an acyl-CoA + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71596", "l": "2-oxoglutarate(out) + succinate(in) => 2-oxoglutarate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297275", "l": "CD9:Izumo Binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803227", "l": "Dissociation of high activity BRAF complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607722", "l": "Active NIK phosphorylates IKKA dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72663", "l": "De novo formation of eIF2:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694522", "l": "Inner coat assembly and cargo binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72404", "l": "2-oxoglutarate(out) + urate(in) => 2-oxoglutarate(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72749", "l": "leukotriene E4(in) => leukotriene E4(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68338", "l": "(R)-pantetheine sulfonate + phosphate => (R)-4'-phosphopantetheine sulfonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40099", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33854", "l": "GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) <=> GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67902", "l": "glutaryl-CoA + succinate => glutarate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71297", "l": "chloride(in) + 2 Na(+)(in) + O-propanoyl-(R)-carnitine(in) => chloride(out) + 2 Na(+)(out) + O-propanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731075", "l": "Syndecan-1 binds collagen types I, III, V (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001066", "l": "plastid single subunit type RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type plastid RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25411", "l": "ADP-alpha-D-glucose + D-glucose <=> ADP + alpha,alpha-trehalose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53862", "l": "dehydrocholate + H(+) + NADPH => 7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68611", "l": "Formation of ORC(1-5) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41643", "l": "3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44288", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706304", "l": "Active FLT3 binds to GRAP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70413", "l": "4-hydroxyphenylacetate + CoA + H(+) => 4-hydroxyphenylacetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865256", "l": "CDKN1A gene expression is stimulated by TFAP2A and repressed by TFAP2C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369080", "l": "PRLR binds STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247497", "l": "ERBB3 binds neuregulins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32376", "l": "limonene-1,2-diol + NAD(+) => 1-hydroxylimonen-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21017", "l": "H2O + L-asparagine => L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59803", "l": "decanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] <=> CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18476", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429698", "l": "PRKD1,2,3 phosphorylates CERT1-2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46123", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68712", "l": "(2E,6E)-farnesyl diphosphate = (1S,2S,4R)-beta-elemene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50882", "l": "4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+) => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36018", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9613497", "l": "Unwinding DNA for the nascent transcript (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72682", "l": "(R)-dihydrolipoate + ATP + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73680", "l": "3'-AMP(in) + ADP(out) + H(+)(out) => 3'-AMP(out) + ADP(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210290", "l": "Interaction of PECAM-1 and SHIP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011971", "l": "Estrogen-responsive MYB gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69968", "l": "Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) => Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947531", "l": "Molybdenum ion transfer onto molybdopterin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603251", "l": "Defective ACTH does not bind MCR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296233", "l": "T2Rs bind bitter-tasting compounds (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939205", "l": "ESTG translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35834", "l": "2-oxoglutarate + kanamycin B + O2 <=> 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810159", "l": "HOXB2 chromatin is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70241", "l": "PCK1 phosphorylates OA to yield PEP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54858", "l": "ethyl hexanoate + H2O + NADP(+) => H(+) + NADPH + O2 + octan-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72553", "l": "glutarate(in) + urate(out) => glutarate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61484", "l": "a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15983", "l": "CO2 + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018487", "l": "vanillate O-demethylase (anaerobic) activity", "d": ["Catalysis of the reaction: vanillate + Co+ = Co3+-CH3 + 3,4-dihydroxybenzoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30331", "l": "all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.24", "l": "\"beta-carotene 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030757", "l": "3-methylquercitin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016992", "l": "lipoate synthase activity", "d": ["Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73371", "l": "(R)-pantothenate(out) + 2 Na(+)(out) = (R)-pantothenate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983158", "l": "Trimming of peptides in ER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28303", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + germacrene C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62719", "l": "stemphyloxin I <=> stemphyloxin II", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0015924", "l": "mannosyl-oligosaccharide mannosidase activity", "d": ["Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28706", "l": "Cu(2+)(in) <=> Cu(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114284", "l": "Release of Cytochrome c from mitochondria (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72473", "l": "citrate(in) + D-threo-isocitrate(out) => citrate(out) + D-threo-isocitrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009016", "l": "succinyldiaminopimelate transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106356", "l": "4-hydroxybenzoate 3-monooxygenase [NADPH] activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP+."]}, {"i": "RHEA:19477", "l": "4-hydroxybenzoate + H(+) + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30711", "l": "(S)-linalool = beta-myrcene + H2O", "d": []}, {"i": "EC:4.2.1.127", "l": "\"linalool dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452392", "l": "Transcription of POU5F1 (OCT4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640167", "l": "RRAGA,B exchanges GDP for GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.120", "l": "\"cyclohexane-1-carbonyl-CoA reductase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140834", "l": "RNA polymerase II CTD heptapeptide repeat S2 kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.2.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55053", "l": "H2O + pentanoyl-CoA => CoA + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44899", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618584", "l": "CEBPB and phospho-STAT3 bind the promoter of the MYC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416510", "l": "GRK5 sequesters activated Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51585", "l": "4-(trimethylamino)butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954117", "l": "E2F6:TFDP1 binds EPC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791016", "l": "SFTPB binds itself (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019776", "l": "Atg8-family ligase activity", "d": ["Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 family modifer to phosphatidylethanolamine or phosphatidylserine on a membrane."]}, {"i": "REACT:R-HSA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186798", "l": "GAP binds to PDGF-beta receptors only (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28053", "l": "H2O + NADP(+) <=> NAD(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102889", "l": "beta-elemene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> beta-elemene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9763200", "l": "BRCA2 mutants do not bind SEM1 (DSS1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995330", "l": "COX10 transforms heme to heme O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40252", "l": "4-O-methylrhodomycin D + H2O => 10-carboxy-13-deoxydaunorubicin + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720478", "l": "Defective ALG9 does not add the seventh mannose to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371554", "l": "HSF1 acetylation at Lys80 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64386", "l": "alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine => H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964619", "l": "PAK1 binds ARHGEF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.328", "l": "\"nicotine blue oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56656", "l": "12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.69", "l": "\"monoterpenol O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47494", "l": "isodeoxycholate + NAD(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863011", "l": "p25-bound CDK5 phosphorylates CDC25C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42381", "l": "2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O => 2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17643", "l": "agmatine + CO2 => H(+) + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37272", "l": "ATP + H2O + L-alanyl-L-glutamine(out) => ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018774", "l": "RHOBTB1 binds GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64206", "l": "1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791035", "l": "Release of NS1 homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64895", "l": "holo-[ACP] + tetradecanoyl-AMP <=> AMP + H(+) + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22005", "l": "ATP + L-seryl-[myosin light chain] => ADP + H(+) + O-phospho-L-seryl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64060", "l": "(S)-phenylacetylcarbinol + NAD(+) = 1-phenyl-1,2-propanedione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209925", "l": "DIT and MIT combine to form triiodothyronine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32286", "l": "3-hydroxyanthranilate + O2 <=> H(+) + H2O + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53367", "l": "5,6-dihydrouridine(47) in tRNA + NAD(+) <=> H(+) + NADH + uridine(47) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944240", "l": "Association of procollagen type III (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901531", "l": "hypochlorite binding", "d": ["Binding to hypochlorite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093330", "l": "EPHB binds p120-RasGAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944420", "l": "MAF1 binds the PTEN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047915", "l": "ganglioside galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59808", "l": "L-tyrosine = D-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50131", "l": "NAD(+) + resolvin D1 <=> 17-oxoresolvin D1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35666", "l": "a 1,2-diacyl-sn-glycerol + H2O <=> a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49558", "l": "H(+) + L-cysteinyl-[protein] + lactate => H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29871", "l": "ATP + H2O + thiosulfate(out) = ADP + H(+) + phosphate + thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956365", "l": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606807", "l": "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42023", "l": "11-dehydrocorticosterone + NAD(+) <=> H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0036009", "l": "protein-glutamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamine = S-adenosyl-L-homocysteine + protein N-methyl-L-glutamine."]}, {"i": "REACT:R-HSA-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.86", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69824", "l": "(22S)-22-hydroxycampest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] => (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050581", "l": "D-mannitol oxidase activity", "d": ["Catalysis of the reaction: mannitol + O2 = mannose + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61476", "l": "a sphingoid base + octadecanoyl-CoA = an N-octadecanoyl-sphingoid base + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.299", "l": "\"sphingoid base N-stearoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39957", "l": "(9Z)-octadecenoate + glycerol + H(+) => (9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853496", "l": "SCF:FBXL7 binds AURKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64330", "l": "cholesteryl (7Z)-octadecenoate + CoA => (7Z)-octadecenoyl-CoA + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50826", "l": "14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64232", "l": "8 H(+) + holo-[ACP] + 8 malonyl-CoA = atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134954", "l": "DHX9 binds DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444476", "l": "FPRL2 receptor binds a wide range of ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66173", "l": "H(+)(out) + L-cystine(out) => H(+)(in) + L-cystine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37365", "l": "5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O => 5 AH2 + 2 H(+) + heme b + 4 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0097644", "l": "calcitonin family binding", "d": ["Binding to a member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs))."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29598", "l": "CoA + NADP(+) + sulfoacetaldehyde <=> H(+) + NADPH + sulfoacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72185", "l": "mRNA polyadenylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-445079", "l": "Phosphorylation of L1 by ERK (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199456", "l": "PTEN dephosphorylates PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58085", "l": "1-(13Z-docosenoyl)-glycerol + H2O => (13Z)-docosenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37181", "l": "(6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2262777", "l": "TRAF6 binds to p-IRAK2   (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72985", "l": "6-(3-dimethylallyl)harmol + diphosphate => dimethylallyl diphosphate + harmol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944263", "l": "Association of procollagen type II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58714", "l": "H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide => NADH + O2 + rifampicin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25534", "l": "diphosphate + ent-cassa-12,15-diene => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71718", "l": "H(+)(out) + L-leucyl-L-leucine(out) <=> H(+)(in) + L-leucyl-L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23138", "l": "a methylated primary amine + H(+) + S-adenosyl-L-homocysteine => a primary amine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034889", "l": "endosulfan hemisulfate sulfatase activity", "d": ["Catalysis of the reaction: endosulfan hemisulfate + H2O = endosulfan monoalcohol + 2 H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972964", "l": "POU5F1 (OCT4), SOX2, NANOG bind the FOXD3 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050401", "l": "xylonate dehydratase activity", "d": ["Catalysis of the reaction: D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44432", "l": "2 a 1-acylglycerol = a 1,2-diacylglycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.105", "l": "\"2-hydroxyisoflavanone dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507869", "l": "Aquaporins passively transport glycerol into cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693125", "l": "RHOF binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25445", "l": "(2E,6E)-farnesyl diphosphate => (1E,4E)-germacrene B + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25373", "l": "3-(1-carboxyvinyloxy)anthranilate + FMNH2 => (2S)-2-amino-4-deoxychorismate + FMN", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23815", "l": "(+)-neomenthol + NADP(+) <=> (1R,4S)-menthone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692764", "l": "MAPK6 binds CCND3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350058", "l": "Formation of CSL NCOR corepressor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60948", "l": "(S)-eriodictyol + S-adenosyl-L-methionine = (S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43400", "l": "N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23824", "l": "(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) = 2,3-dihydroxybenzoate + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.28", "l": "\"2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52143", "l": "a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O <=> a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41209", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38428", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56290", "l": "H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase] => albendazole + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59885", "l": "2-oxoglutarate + chloride + H(+) + L-lysine + O2 => 4-chloro-L-lysine + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177934", "l": "EGFR autophosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.870242003977111", "identifiers": [{"i": "GO:0030546", "l": "signaling receptor activator activity", "d": ["The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5228992", "l": "ROCK1,ROCK2 are activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40119", "l": "H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23923", "l": "(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68450", "l": "(3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 13-cis-10'-apo-lycopenal => 13-cis-lycopene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54673", "l": "(+)-kolavenyl diphosphate + H2O => (+)-kolavelool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31957", "l": "9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44141", "l": "CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate => acetyl-CoA + CO2 + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45274", "l": "12-hydroxy-(9Z)-octadecenoate + phosphate => 12-phosphooxy-(9Z)-octadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53473", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5660666", "l": "CBP and p300 binds NF-kB complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140295", "l": "pathogen-derived receptor ligand activity", "d": ["The activity of a pathogen-derived entity that interacts with a host receptor to activate effector-triggered immunity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28142", "l": "H2O + streptothricin D = streptothricin D acid", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0043559", "l": "insulin binding", "d": ["Binding to insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71518", "l": "hypoxanthine(out) <=> hypoxanthine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170978", "l": "p-FRS2:CRKL binds C3G (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66706", "l": "CoA + H(+) + mycophenolate => H2O + mycophenolyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215295", "l": "USP7 deubiquitinates MDM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59901", "l": "2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 => CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951486", "l": "CD46 binds C4b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37387", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72095", "l": "Internal Methylation of mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0005221", "l": "intracellular cyclic nucleotide activated monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a monoatomic cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts."]}, {"i": "REACT:R-HSA-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25937", "l": "8-methylquinoline + A + H2O => 8-methylquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865605", "l": "BRWD1 binds SMARCA4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44240", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71065", "l": "L-arginine(out) + L-histidine(in) => L-arginine(in) + L-histidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734573", "l": "Expression of GATA6 in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50516", "l": "acetyl-CoA + N-terminal L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18661", "l": "H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) = H(+) + L-ornithine + NADPH + pyruvate", "d": []}, {"i": "EC:1.5.1.24", "l": "\"N(5)-(carboxyethyl)ornithine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42845", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH => 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66966", "l": "alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76456", "l": "O-atom dealkylation of dextromethorphan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37957", "l": "(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.3.2.3", "l": "\"ABC-type sulfate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156678", "l": "Activation of Cdc25C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399952", "l": "Phosphorylation of LIMK-1 by PAK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38390", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21188", "l": "ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)", "d": []}, {"i": "EC:6.3.1.5", "l": "\"NAD(+) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165179", "l": "Formation of TSC1:TSC2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857348", "l": "Activated CEBPB stimulates transcription of CDKN2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002428", "l": "Removal of fibrillar collagen N-propeptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76086", "l": "(11R)-carlactone + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-19-hydroxycarlactone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50227", "l": "3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.8", "l": "\"limonene dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0102973", "l": "norsolorinate anthrone synthase activity", "d": ["Catalysis of the reaction: 7 malonyl-CoA + 5 H+ + a hexanoyl-[acyl-carrier-protein] = norsolorinate anthrone + 7 coenzyme A + 7 carbon dioxide + 2 H2O + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629679", "l": "PDE3A inhibitors bind PDE3A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015107", "l": "chlorate transmembrane transporter activity", "d": ["Enables the transfer of chlorate, ClO3-, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10717", "l": "D-glucose 6-phosphate => 1D-myo-inositol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428510", "l": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45823", "l": "mesaconate + succinyl-CoA <=> 2-methylfumaryl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005078", "l": "MAP-kinase scaffold activity", "d": ["The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033766", "l": "2-hydroxyquinoline 8-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + quinolin-2-ol = H2O + NAD+ + quinoline-2,8-diol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52627", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate <=> [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.43", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202453", "l": "Auto-ubiquitination of TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54856", "l": "H(+) + NADPH + O2 + octan-3-one = ethyl hexanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63395", "l": "A + Fe(II)-heme o + H2O <=> AH2 + Fe(II)-heme i", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592278", "l": "Autocatalytic activation of proMMP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38826", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047656", "l": "alpha,alpha-trehalose phosphorylase activity", "d": ["Catalysis of the reaction: alpha,alpha-trehalose + phosphate = D-glucose + beta-D-glucose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70586", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43372", "l": "an N-acylsphing-4-enine + dTDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53169", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73691", "l": "3'-AMP(out) + phosphate(in) = 3'-AMP(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9714483", "l": "RAC2 translocates to the ER membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392831", "l": "Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46833", "l": "4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH => 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004320", "l": "oleoyl-[acyl-carrier-protein] hydrolase activity", "d": ["Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252001", "l": "ATP1B4 binds SNW1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2404142", "l": "atROL binds RBP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941312", "l": "TUT4,TUT7 oligouridylate mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781953", "l": "YOD1 binds VCP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445069", "l": "L1-EGFR trans-heterodimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55802", "l": "an N-acyleicosasphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36568", "l": "GDP-beta-L-colitose + NAD(+) => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49177", "l": "12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067667", "l": "IL6 binds IL6R (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656254", "l": "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39462", "l": "(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52744", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + H2O = alpha-isomaltosyl-(1->3)-isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803890", "l": "SFN dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202966", "l": "Caspase mediated cleavage of HIP-55 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13605", "l": "2 L-ascorbate + O2 = 2 H2O + 2 L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58528", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH = (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11005", "l": "2 H(+) + NADH + O2 + salicylate => catechol + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68234", "l": "L-cysteine(out) + Na(+)(out) => L-cysteine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73953", "l": "beta-maaliene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417890", "l": "P2Y5 receptor can bind to LPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17080", "l": "H2O + N,N-dimethylglycine + O2 <=> formaldehyde + H2O2 + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035410", "l": "dihydrotestosterone 17-beta-dehydrogenase activity", "d": ["Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54775", "l": "ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide <=> 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14119", "l": "[(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate => [(1->4)-alpha-D-galacturonosyl](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22880", "l": "2-oxoglutarate + L-arogenate = L-glutamate + prephenate", "d": []}, {"i": "EC:2.6.1.79", "l": "\"glutamate--prephenate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-901047", "l": "Binding of ERp57 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44052", "l": "alpha,alpha-trehalose + hexadecanoyl-CoA = 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61406", "l": "ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine => ATP + N-(D-ribulosyl)-cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16609", "l": "AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine", "d": []}, {"i": "EC:2.4.2.7", "l": "\"adenine phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854222", "l": "TBC1D3 associates with RAB5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50148", "l": "a fatty acid ethyl ester + H2O = a fatty acid + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73992", "l": "geranylgeranyl diphosphate => beta-araneosene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389083", "l": "Autophosphorylation of PDGF alpha receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704297", "l": "CHRM2 binds CHRM2 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32786", "l": "ATP + glycine betaine(out) + H2O <=> ADP + glycine betaine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34783", "l": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610723", "l": "GLI proteins bind SUFU (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41377", "l": "1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49987", "l": "H(+) + jasmonate + NADPH + O2 <=> (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62336", "l": "AMP + ATP = adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44150", "l": "D-beta-lysine => L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49977", "l": "butanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047727", "l": "isobutyryl-CoA mutase activity", "d": ["Catalysis of the reaction: isobutyryl-CoA = butanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017058", "l": "FH1 domain binding", "d": ["Binding to a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34663", "l": "20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65352", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177479", "l": "Axonal transport of NGF:Trk complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11691", "l": "ATP + L-leucine + tRNA(Leu) <=> AMP + diphosphate + L-leucyl-tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42193", "l": "(9Z)-pentadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-pentadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0072320", "l": "volume-sensitive chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.82", "l": "\"glutamyl endopeptidase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23990", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate => (2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39796", "l": "7beta-hydroxycholesterol(in) + ATP + H2O => 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58441", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944233", "l": "Association of procollagen type XIX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.132", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58156", "l": "ATP + H2O + 4 Na(+)(in) = ADP + H(+) + 4 Na(+)(out) + phosphate", "d": []}, {"i": "EC:7.2.2.1", "l": "\"Na(+)-transporting two-sector ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58779", "l": "NADP(+) + pyridine 3-methanol <=> H(+) + NADPH + pyridine-3-carbaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0016635", "l": "oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound."]}, {"i": "EC:1.3.5.-", "l": "\"With a quinone or related compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42144", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.162", "l": "\"N-acetylhexosamine 1-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67026", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51832", "l": "ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46211", "l": "ATP + CoA + eicosanoate <=> AMP + diphosphate + eicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877345", "l": "IL2 gene expression is stimulated by RUNX1 and NFATC2 and repressed by FOXP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928657", "l": "MMP2,9 cleave EPHB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11846", "l": "CoA + pyruvate => acetyl-CoA + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635842", "l": "ULK3 phosphorylates GLI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.56", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.51", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014296", "l": "RAC2 GEFs activate RAC2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10246", "l": "acetoacetate + fumarate + H(+) => 4-fumarylacetoacetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357483", "l": "RAC1 binds PAK1-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388833", "l": "Phosphorylation of CTLA-4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944247", "l": "Association of procollagen type VI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071161", "l": "cyanophycin synthetase activity (L-arginine-adding)", "d": ["Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-arginine = ADP + phosphate + [L-Asp(4-L-Arg)]n+1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51957", "l": "(E)-2-methylpropanal oxime => (Z)-2-methylpropanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62822", "l": "1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O => 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19073", "l": "ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein]", "d": []}, {"i": "EC:2.7.11.10", "l": "\"IkappaB kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34598", "l": "H(+) + isopentadecanoyl-CoA + L-serine <=> 3-dehydro-15-methylhexadecasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73490", "l": "a carboxylate(in) + orotate(out) <=> a carboxylate(out) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67126", "l": "an alcohol + S-hydroxy-L-cysteinyl-[protein] => a hydroperoxide + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3965450", "l": "DAAM1 recruits PFN1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18337", "l": "D-ribose 5-phosphate + uracil = H2O + psi-UMP", "d": []}, {"i": "EC:4.2.1.70", "l": "\"pseudouridylate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29734", "l": "beta-maltose(in) <=> beta-maltose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45058", "l": "H(+) + H2O + nogalonate => deoxynogalonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37823", "l": "(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40945", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102255", "l": "neo-lambda-carrahexaose hydrolase activity", "d": ["Catalysis of the reaction: neo-lambda-carrahexaose + H2O <=> neo-lambda-carratetraose + neo-lambda-carrabiose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707594", "l": "Hemes bind LY96 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983422", "l": "Disassembly of COPII coated vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18745", "l": "2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)", "d": []}, {"i": "EC:1.17.3.4", "l": "\"juglone 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190541", "l": "Association of Cx43 with TJP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22698", "l": "A + H2O + testololactone => AH2 + androst-4-ene-3,17-dione + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33671", "l": "an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O = 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106138", "l": "Sec61 translocon complex binding", "d": ["Binding to a Sec61 translocon complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445700", "l": "Myosin Binds ATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59465", "l": "NADP(+) + octadecan-1-ol => H(+) + NADPH + octadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51702", "l": "4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + xanthogalenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.50", "l": "\"lysyl endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50455", "l": "prostaglandin H3 <=> prostaglandin E3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421836", "l": "trans-Golgi Network Derived Vesicle Uncoating (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170674", "l": "Dissociation of the Gi alpha:G olf complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757686", "l": "SERPINA6 binds PREDL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156682", "l": "PLK1 phosphorylates NUDC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22708", "l": "H2O + S-acylglutathione = a carboxylate + glutathione + H(+)", "d": []}, {"i": "EC:3.1.2.7", "l": "\"glutathione thiolesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.443919496911477", "identifiers": [{"i": "GO:0016627", "l": "oxidoreductase activity, acting on the CH-CH group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27889", "l": "2',3'-cyclophospho-AMP + H2O <=> 3'-AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75433", "l": "32-oxoeburicol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 32-hydroxyeburicol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47964", "l": "H2O + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72671", "l": "eIF5B:GTP is hydrolyzed and released (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50869", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45325", "l": "H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57837", "l": "H2O + O2 + thermospermine => 3-aminopropanal + H2O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110210", "l": "TDG glycosylase mediated recognition and binding of an ethenocytosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047418", "l": "phthalyl amidase activity", "d": ["Catalysis of the reaction: H2O + a phthalylamide = phthalate + substituted amine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869580", "l": "DEK binds TFAP2A homodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12187", "l": "(S,S)-butane-2,3-diol + NAD(+) <=> (S)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35984", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54155", "l": "a uridine in rRNA + S-adenosyl-L-methionine <=> a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69046", "l": "fumarate + H(+) + nitrite => 2-nitrobutanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202731", "l": "JAM3 dimerises (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683735", "l": "CHEK2 is recruited to DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38487", "l": "1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68263", "l": "D-serine(in) + Na(+)(in) <=> D-serine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31882", "l": "(S)-2,3-epoxysqualene <=> beta-seco-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804741", "l": "MDM2 forms homo- or heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9658253", "l": "RAS:GTP binds PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210282", "l": "Interaction of GPVI and FceRI gamma (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.44", "l": "\"homospermidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71604", "l": "2-oxoglutarate(out) + oxaloacetate(in) => 2-oxoglutarate(in) + oxaloacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5634228", "l": "TRAF1 is cleaved by caspases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29625", "l": "alpha-maltohexaose + beta-D-glucose => alpha-maltopentaose + beta-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64697", "l": "benzyl alcohol + NAD(+) => benzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004552", "l": "octanol dehydrogenase activity", "d": ["Catalysis of the reaction: 1-octanol + NAD+ = 1-octanal + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626228", "l": "The distal appendage proteins recruit TTBK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210881", "l": "Dimerization of Tie2/Ang1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140902", "l": "L-glutamine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-glutamine(out) + Na+(out) = L-glutamine(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58972", "l": "H2O + O2 + vanillin = H(+) + H2O2 + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29197", "l": "a menaquinol + orotate => (S)-dihydroorotate + a menaquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29381", "l": "2'-deoxyguanosine + phosphate => dGMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13498", "l": "5-dehydro-2-deoxy-D-gluconate + ATP => 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36269", "l": "formaldehyde + H2O + NAD(+) + theobromine => caffeine + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50712", "l": "chloride + FADH2 + O2 + tetracycline = 7-chlorotetracycline + FAD + H(+) + 2 H2O", "d": []}, {"i": "EC:1.14.19.49", "l": "\"tetracycline 7-halogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15307", "l": "glycine betaine + 2 H(+) + NADH => betaine aldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676595", "l": "TRAFs bind RANK:RANKL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48314", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+) => benzoyl-CoA + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004097", "l": "catechol oxidase activity", "d": ["Catalysis of the reaction: 2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone. This reaction catalyzes exclusively the oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668395", "l": "CHMP7 binds CC2D1B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983259", "l": "Kinesins move along microtubules consuming ATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663354", "l": "SLC26A5 (prestin) changes conformation in response to depolarization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45688", "l": "N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) = N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52511", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10456", "l": "acetyl-CoA + D-maltose = 1-O-acetylmaltose + CoA", "d": []}, {"i": "EC:2.3.1.79", "l": "\"maltose O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11997", "l": "biphenyl-2-ol + H(+) + NADH + O2 => biphenyl-2,3-diol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50033", "l": "H2O + hexadecanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60018", "l": "diphosphate + sesquisabinene B => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.62", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1222491", "l": "Lactoferrin scavenges iron ions (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36066", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + kunzeaol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15290", "l": "[(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose => [(1->4)-beta-D-xylan](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10799", "l": "albendazole + H(+) + NADPH + O2 <=> albendazole S-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693761", "l": "FA2H hydroxylates CERA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201637", "l": "Caspase-mediated cleavage of plectin-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51795", "l": "H(+) + NADH + O2 + salicylate <=> 2,3-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2470508", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036403", "l": "arachidonate 8(S)-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (5Z,8S,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614544", "l": "Sulfite is oxidized to sulfate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211968", "l": "CYP2W1 oxidises INDOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983422", "l": "Disassembly of COPII coated vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40774", "l": "(20S)-ginsenoside Rg1 + H2O <=> (20S)-ginsenoside F1 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30361", "l": "chlorophyllide b + 3 H2O + 2 NADP(+) => chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51593", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene => benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004105", "l": "choline-phosphate cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17946", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39379", "l": "(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH = (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862380", "l": "HSD17B13 binds lipid droplets (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20754", "l": "AH2 + 2 aquacob(III)alamin => A + 2 cob(II)alamin + 2 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000285", "l": "1-phosphatidylinositol-3-phosphate 5-kinase activity", "d": ["Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696564", "l": "USP25 deubiquitinates DDX58 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19022", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761110", "l": "BHLHE22 homodimer binds intron 1 of CDH11 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754129", "l": "CDK6 inhibitors bind CDK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225956", "l": "Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28644", "l": "(2E,6E)-farnesyl diphosphate => alpha-zingiberene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35642", "l": "(4S)-4-hydroxy-2-oxoglutarate <=> glyoxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43533", "l": "a ribonucleoside 3',5'-bisphosphate + H2O => a ribonucleoside 5'-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69035", "l": "N,N-dihydroxy-L-aspartate <=> (2S)-2-nitrosobutanedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50117", "l": "eicosanoyl-CoA + taurine => CoA + H(+) + N-eicosanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37793", "l": "aclacinomycin Y + H2O2 => aclacinomycin A + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.783030043623796", "identifiers": [{"i": "GO:0004659", "l": "prenyltransferase activity", "d": ["Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34178", "l": "2-hydroxybenzoyl-CoA + malonyl-CoA <=> 4-hydroxycoumarin + CO2 + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74357", "l": "a uridine in mRNA + NH4(+) => a cytidine in mRNA + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9702818", "l": "CALCR binds erenumab (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44069", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67758", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796691", "l": "SPATA2 links CYLD to LUBAC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685156", "l": "ATR phosphorylates RPA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156930", "l": "GTP-binding activates eEF2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080071", "l": "indol-3-yl-methyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: indol-3-yl-methyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = indol-3-yl-methyl-glucosinolate + adenosine 3',5'-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634390", "l": "ERBB2 homodimer phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018804", "l": "RAC3 GEFs activate RAC3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18185", "l": "adenosine + O2 = 5'-dehydroadenosine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0031811", "l": "G protein-coupled nucleotide receptor binding", "d": ["Binding to a G protein-coupled (metabotropic) nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27456", "l": "iodide + L-tyrosine + NADP(+) <=> 3-iodo-L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76000", "l": "glutarate(in) + kynurenate(out) => glutarate(out) + kynurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.38", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11344", "l": "an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate + diphosphate", "d": []}, {"i": "EC:2.7.7.43", "l": "\"N-acylneuraminate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380574", "l": "Dopamine synaptic vesicle docking and priming (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75133", "l": "morphinone => neomorphinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17937", "l": "dihydroxyacetone phosphate = methylglyoxal + phosphate", "d": []}, {"i": "EC:4.2.3.3", "l": "\"methylglyoxal synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31558", "l": "(5S)-5-amino-3-oxohexanoate + acetyl-CoA <=> (3S)-3-aminobutanoyl-CoA + acetoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75757", "l": "10-hydroxyoctadecanoate => (10E)-octadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38961", "l": "a (2E)-enoyl-CoA + H2O2 => a 2,3-saturated acyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112395", "l": "Abortive termination of elongation after arrest (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798372", "l": "ATM phosphorylates DYRK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22456", "l": "creatine + H2O = sarcosine + urea", "d": []}, {"i": "EC:3.5.3.3", "l": "\"creatinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11331", "l": "dimethylallyl diphosphate + isopentenyl diphosphate <=> diphosphate + neryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0071553", "l": "G protein-coupled pyrimidinergic nucleotide receptor activity", "d": ["Combining with a pyrimidine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102628", "l": "costunolide 3beta-hydroxylase activity", "d": ["Catalysis of the reaction: costunolide + NADPH + O2 + H+ <=> 3beta-hydroxycostunolide + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16119", "l": "acetoacetyl-CoA + AMP + diphosphate => acetoacetate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10342", "l": "(-)-vetispiradiene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57058", "l": "D-apionolactone + H(+) + NADH => D-apiofuranose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72058", "l": "glycodeoxycholate(out) + 2 Na(+)(out) <=> glycodeoxycholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35344", "l": "3-hydroxydocosanoyl-CoA + NADP(+) => 3-oxodocosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166753", "l": "Conversion of C4 into C4a and C4b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114683", "l": "Phosphorylation of Platelet Sec-1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73832", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => an alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336420", "l": "DT fragment B transports DT fragment A from target cell endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618328", "l": "ATAT acetylates microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61976", "l": "glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047369", "l": "succinate-hydroxymethylglutarate CoA-transferase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1878002", "l": "XYLTs transfer Xyl to core protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166869", "l": "TRAF6 binds MEKK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76456", "l": "O-atom dealkylation of dextromethorphan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664879", "l": "ATM:PEX5 binds ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635842", "l": "ULK3 phosphorylates GLI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44679", "l": "a triacyl-sn-glycerol + all-trans-retinol <=> a diacylglycerol + an all-trans-retinyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67548", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18535", "l": "CO2 + serotonin => 5-hydroxy-L-tryptophan + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71140", "l": "acetyl-CoA + 3 AH2 + 18 H(+) + 10 malonyl-CoA + 8 NADPH => 3 A + 10 CO2 + 11 CoA + cordypyrone A + 8 H2O + 8 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28806", "l": "H2O + L-ascorbate 6-phosphate <=> 3-dehydro-L-gulonate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48592", "l": "a quinone + formate + H(+) = a quinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32635", "l": "linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.84", "l": "\"linalool 8-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17240", "l": "ATP + FMN + H(+) <=> diphosphate + FAD", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51673", "l": "glyoxal + H2O => glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22772", "l": "L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O", "d": []}, {"i": "EC:4.2.1.68", "l": "\"L-fuconate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57959", "l": "dimethyl sulfoxide + H(+) + NADH + O2 <=> dimethyl sulfone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30513", "l": "2-demethylmenaquinol-8 + NADP(+) => 2-demethylmenaquinone-8 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64383", "l": "3 A + phytyl diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61365", "l": "ATP + dehydroepiandrosterone 3-sulfate(in) + H2O => ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34998", "l": "L-rhamnose(in) <=> L-rhamnose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40382", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP <=> 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23591", "l": "oxalate + succinyl-CoA <=> oxalyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418200", "l": "SRC-1 bound to ARRB2 is not activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209178", "l": "N-HH binds to PTC receptor complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201629", "l": "Caspase-mediated cleavage of Tau (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51666", "l": "H(+) + N-carbamoyl-D-phenylglycine => D-5-phenylhydantoin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28174", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate = colneleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20541", "l": "H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 = 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40124", "l": "an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54876", "l": "(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = (3S)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75862", "l": "Fall Back to Closed Pre-initiation Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45927", "l": "9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75652", "l": "(10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate => 12,13-epoxy-(10R)-hydroxy-(8E,15Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39469", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+) => (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.12", "l": "\"T2-induced deoxynucleotide kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20989", "l": "ATP + 2 H2O => AMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080105", "l": "6-methylthiopropyl glucosinolate S-oxygenase activity", "d": ["Catalysis of the reaction: 6-methylthiopropyl-glucosinolate = 6-methylsulfinylpropyl-glucosinolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71173", "l": "H(+)(out) + L-cysteine(in) + Na(+)(in) => H(+)(in) + L-cysteine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213246", "l": "Disassociation of CLIP from MHC II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18070", "l": "L-arginine => D-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36929", "l": "3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA => (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3266557", "l": "Factor I cleaves iC3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665009", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18065", "l": "ATP + H2O + phosphonate(out) = ADP + H(+) + phosphate + phosphonate(in)", "d": []}, {"i": "EC:7.3.2.2", "l": "\"ABC-type phosphonate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703434", "l": "FLT3 fusions recruit PIK3CA through PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75852", "l": "all-trans-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034942", "l": "cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity", "d": ["Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = cis-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854209", "l": "TBC1D10A binds JFC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627107", "l": "XIAP binds CASP7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27460", "l": "3-iodo-L-tyrosine + iodide + NADP(+) <=> 3,5-diiodo-L-tyrosine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75013", "l": "9-(9Z-octadecenoyloxy)-octadecanoate + di-(9Z)-octadecenoylglycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36000", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018501", "l": "cis-chlorobenzene dihydrodiol dehydrogenase activity", "d": ["Catalysis of the conversion of a di- or tetrachlorinated dienol to the corresponding catechol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534388", "l": "Progesterone Activation Of CatSper (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54263", "l": "2-oxoglutarate + L-asparaginyl-[protein] + O2 <=> (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203567", "l": "palmitoylation of eNOS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606602", "l": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69270", "l": "an alkenyl isothiocyanate + sulfate => a (Z)-N-(sulfonatooxy)alkenimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27785", "l": "4-hydroxybenzoate + all-trans-octaprenyl diphosphate <=> 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029680", "l": "Caspase-7 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41519", "l": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604642", "l": "Proteasome degrades ubiquitinated NICD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29405", "l": "3-demethylubiquinol-8 + A + H2O => 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44921", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH => (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047775", "l": "citramalate CoA-transferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827992", "l": "Expression of TET2 in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169891", "l": "ARMS:Crk complex binds to active TrkA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75179", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (R)-axinyssene + diphosphate", "d": []}, {"i": "EC:4.2.3.209", "l": "\"(R)-axinyssene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16122", "l": "5,6-dihydrouracil + H2O => 3-(carbamoylamino)propanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218642", "l": "PTK2 autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15713", "l": "a beta-D-galactoside + acetyl-CoA = a 6-acetyl-beta-D-galactoside + CoA", "d": []}, {"i": "EC:2.3.1.18", "l": "\"galactoside O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199518", "l": "C3d-complexed antigen binds to complement receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848751", "l": "PTK6 binds AKT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981931", "l": "RAC1 and CDC42 activate PAK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16512", "l": "H(+) + oxalate <=> CO2 + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9007447", "l": "E2F6 forms the PRC1L4 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11109", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate => n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354173", "l": "Activation of Rap1 by cytosolic GEFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110311", "l": "POLZ extends translesion synthesis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.15", "l": "\"(S)-2-hydroxy-acid oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52844", "l": "3,4-dihydroxybenzoate + UDP-alpha-D-glucose = 1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50646", "l": "3-(3-methylsulfanyl)propylmalate => 2-(3-methylsulfanyl)propylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61727", "l": "a D-glucoside + NAD(+) <=> a 3-dehydro-D-glucoside + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.1.-", "l": "\"Hydron translocation or charge separation linked to oxidoreductase reactions\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-169895", "l": "Crk's SH3 domain engages C3G (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793217", "l": "Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47910", "l": "6-deoxy-6-sulfo-D-gluconate + H(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21150", "l": "5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP => indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362437", "l": "C-terminal Hh fragments are bound by lectins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625029", "l": "SLC1A1 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6791016", "l": "SFTPB binds itself (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050076", "l": "maleate isomerase activity", "d": ["Catalysis of the reaction: maleate = fumarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39552", "l": "(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH => (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0140805", "l": "NAD+-protein-serine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-seryl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]."]}, {"i": "RHEA:58232", "l": "L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210277", "l": "Interaction of PECAM-1 and SHP-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12010", "l": "[G-protein-coupled receptor]-phosphate + ADP + H(+) => [G-protein-coupled receptor] + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216202", "l": "Phosphorylated SMO changes conformation and is activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013109", "l": "RHOC GEFs activate RHOC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211193", "l": "Homodimerization  of DFF40 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42291", "l": "6-carboxyhexanoyl-[ACP] + H(+) + L-alanine <=> (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30222", "l": "dimethyl sulfoxide + H2O + NAD(+) <=> dimethyl sulfone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13419", "l": "H(+) + NADH + xanthommatin => 5,12-dihydroxanthommatin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69142", "l": "Recruitment of Dna2 endonuclease (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34295", "l": "2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose = 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58925", "l": "(3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol => (-)-maackiain + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32720", "l": "L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31075", "l": "(3S)-3-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18645", "l": "2 putrescine = NH4(+) + sym-homospermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1362465", "l": "GHBP binds GHR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16927", "l": "(E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine => (E)-caffeoyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047415", "l": "D-benzoylarginine-4-nitroanilide amidase activity", "d": ["Catalysis of the reaction: N(2)-benzoyl-D-arginine-4-nitroanilide + H2O = 4-nitroaniline + N(2)-benzoyl-D-arginine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211950", "l": "CYP24A1 24-hydroxylates CTL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13123", "l": "3-phosphoshikimate + ADP + H(+) => ATP + shikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18015", "l": "ethylamine + L-glutamate => H2O + N(5)-ethyl-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871226", "l": "RET binds GFRA1,GFRA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166015", "l": "Association of LBP with LPS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9669854", "l": "KIT binds type II TKIs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62097", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 2-(9Z-octadecenoyl)-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24140", "l": "guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.185", "l": "\"23S rRNA (guanosine(2251)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445064", "l": "Activation of Rac1 by VAV2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432067", "l": "Aquaporin-4 passively transports water out of cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030977", "l": "taurine binding", "d": ["Binding to taurine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14213", "l": "ATP + beta-D-fructose 1-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.56", "l": "\"1-phosphofructokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613760", "l": "EGR2 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193068", "l": "CYP17A1 17-hydroxylates PREG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51963", "l": "(Z)-2-methylpropanal oxime <=> 2-methylpropanenitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627350", "l": "SMAC (DIABLO) binds XIAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12042", "l": "3-(imidazol-5-yl)pyruvate + H(+) + NADPH => (S)-3-(imidazol-5-yl)lactate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17065", "l": "(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.36", "l": "\"mevalonate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72663", "l": "De novo formation of eIF2:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2534096", "l": "METAP1/2 demethylates GNAT1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41624", "l": "3-sulfinopropanoyl-CoA + H2O = H(+) + propanoyl-CoA + sulfite", "d": []}, {"i": "EC:3.13.1.4", "l": "\"3-sulfinopropanoyl-CoA desulfinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64288", "l": "2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase] = cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106256", "l": "hydroperoxy icosatetraenoate dehydratase activity", "d": ["A hydroperoxy icosatetraenoate <=> an oxoicosatetraenoate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39508", "l": "3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679028", "l": "JAK3 binds JAK3 inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47039", "l": "uridine in 5S rRNA <=> pseudouridine in 5S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66694", "l": "dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein] => dTDP-beta-L-rhamnose + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601887", "l": "PLD6 dimer cleaves primary piRNA transcript to pre-piRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12417", "l": "beta-alanyl-CoA => acryloyl-CoA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373716", "l": "DCC interacting NCK-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660666", "l": "CBP and p300 binds NF-kB complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8862380", "l": "HSD17B13 binds lipid droplets (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654515", "l": "KAL1 binds HS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682598", "l": "ATM phosphorylates HERC2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30107", "l": "D-serine + NADP(+) = 2-aminomalonate semialdehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961688", "l": "E2F1 binds the FBXO5 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010855", "l": "adenylate cyclase inhibitor activity", "d": ["Binds to and decreases the activity adenylate cyclase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211247", "l": "Cleavage of DNA by DFF40 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008412", "l": "CDK4 phosphorylates RUNX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000827", "l": "inositol-1,3,4,5,6-pentakisphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22478", "l": "4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH => 4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876868", "l": "ECE1 cleaves EDN1(53-90) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190260", "l": "FGFR2b binds to FGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55444", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] = cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.136", "l": "\"polysialic-acid O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45804", "l": "ATP + hydroxylamine + L-glutamate = ADP + L-glutamine hydroxamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15667", "l": "H2O + N(6)-(D-fructosyl)-L-lysyl-[protein] => aldehydo-D-glucose + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102149", "l": "farnesylcysteine lyase activity", "d": ["Catalysis of the reaction: S-[(2E,6E)-farnesyl]-L-cysteine + O2 + H2O <=> (2-trans,6-trans)-farnesal + L-cysteine + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41583", "l": "5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate <=> 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53092", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23772", "l": "(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) = 2,3-dihydroxy-p-cumate + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.58", "l": "\"2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048101", "l": "calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity", "d": ["Catalysis of the reactions: nucleoside 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672973", "l": "MAP2Ks phosphorylate MAPKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039552", "l": "RIG-I binding", "d": ["Binding to RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050188", "l": "phosphoenolpyruvate mutase activity", "d": ["Catalysis of the reaction: phosphoenolpyruvate = 3-phosphonopyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692785", "l": "p-S215 FOXO1 binds RAG gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37042", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 <=> 5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823836", "l": "SMAD2,3, FOXA2, TBXT, and GATA6 bind the GATA4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10735", "l": "ATP + firefly D-luciferin + O2 <=> AMP + CO2 + diphosphate + firefly oxyluciferin + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56902", "l": "globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP => globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912401", "l": "NOTCH4 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001734", "l": "mRNA (N6-adenosine)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U."]}, {"i": "REACT:R-HSA-72095", "l": "Internal Methylation of mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618750", "l": "CaMKII phosphorylates AMPA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203977", "l": "SAR1 Activation And Membrane Binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29687", "l": "alpha-maltoheptaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltohexaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41383", "l": "H(+) + NADH + O2 + toluene <=> 4-methylphenol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67190", "l": "ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + phosphate => ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038006", "l": "netrin receptor activity involved in chemoattraction", "d": ["Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell towards a higher concentration of netrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607002", "l": "Activated protein C cleaves factor VIIIa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61550", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47819", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199131", "l": "PVR binds CD226 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.27", "l": "\"choloyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102977", "l": "nitrilotriacetate monooxygenase activity (FMN-dependent)", "d": ["Catalysis of the reaction: nitrilotriacetate + O2 + FMNH2 = ammoniodiacetate + 2-oxo monocarboxylic acid anion + H2O + FMN."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49181", "l": "a bacteriochlorophyllide d + S-adenosyl-L-methionine => a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65739", "l": "2-oxoglutarate + O2 + octyl sulfate <=> CO2 + H(+) + octanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46669", "l": "21-hydroxyprogesterone + H(+) + NADPH => 5beta-dihydrodeoxycorticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.55", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39550", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA <=> (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030733", "l": "fatty acid O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74742", "l": "Phosphorylation of SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626914", "l": "α2-agonists bind ADRA2A,B,C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71739", "l": "2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18718", "l": "3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine => 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34850", "l": "7,8-dihydromonapterin + H(+) + NADPH <=> 5,6,7,8-tetrahydromonapterin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350578", "l": "NQO1 interaction with ODC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050331", "l": "thiamine-diphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69077", "l": "(R)-noradrenaline + H2O + O2 => (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53557", "l": "(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12504", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) = 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44876", "l": "a 1,3-diacylglycerol + H2O = 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768945", "l": "NPAS4 stimulates FOS gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694732", "l": "3CLp cleaves pp1ab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5140741", "l": "WNT5A binds FZD and ROR receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2430533", "l": "CDK1 phosphorylates MASTL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852019", "l": "MET bound PI3K generates PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34513", "l": "H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP => N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36875", "l": "(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669855", "l": "Dasatinib-resistant KIT mutants do not bind dasatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36479", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA = (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70510", "l": "LDH tetramer oxidises LACT to PYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53436", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772430", "l": "CTNNBIP1 binds beta-catenin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204861", "l": "Interaction of Tie2 and Shc1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306876", "l": "NLRP3 activation by small molecules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52637", "l": "2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 => a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.24", "l": "\"aminopeptidase S\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.67", "l": "\"zingipain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61641", "l": "H(+) + isophthalyl-CoA => benzoyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43754", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5] => acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44970", "l": "NADP(+) + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139918", "l": "Phosphorylation of BIM by JNK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.4", "l": "\"acyl-lipid (11-3)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755304", "l": "MUL1 ubiquitinates UBXN7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37580", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65816", "l": "AH2 + ATP + 2 Co(II)-[methylamine-specific corrinoid protein] + H2O = A + ADP + 2 Co(I)-[methylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43772", "l": "guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.264", "l": "\"23S rRNA (guanine(2069)-N(7))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166817", "l": "Cleavage of C3 by C3 convertases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54134", "l": "a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+) => a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62751", "l": "H2O + lovastatin <=> (S)-2-methylbutanoate + H(+) + monacolin J", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34618", "l": "2-hydroxyethylphosphonate + O2 <=> H(+) + hydrogencarbonate + methylphosphonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54065", "l": "(2E,6E)-farnesyl diphosphate + H2O => 10-epi-cubebol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54540", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] = beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685953", "l": "SIRT6 deacetylates RBBP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45291", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 <=> 2-glyceryl-prostaglandin G2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.69", "l": "\"bontoxilysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19635", "l": "(5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+) => (3S,5S)-3,5-diaminohexanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70307", "l": "beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0019171", "l": "(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity", "d": ["Catalysis of the reaction: a (3R)-hydroxyacyl-[acyl-carrier-protein] = a (2E)-enoyl-[acyl-carrier-protein] + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36481", "l": "(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0070224", "l": "sulfide:quinone oxidoreductase activity", "d": ["Catalysis of the reaction: H2S (hydrogen sulfide) + a quinone = S0 (sulfane sulfur) + a hydroquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462039", "l": "Pro-HNP1-4 are cleaved to biologically active defensin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35380", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA => (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975098", "l": "MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55068", "l": "a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] = a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017118", "l": "lipoyltransferase activity", "d": ["Catalysis of the reaction: (R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = (R)-N6-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H+."]}, {"i": "RHEA:20473", "l": "(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10359", "l": "3alpha-hydroxy-5beta-androstan-17-one + NAD(+) <=> 5beta-androstane-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45936", "l": "3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693609", "l": "ATM phosphorylates TP53 at S15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202137", "l": "AKT1 binds eNOS complex via HSP90 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70775", "l": "6-sulfo-D-quinovose + FMNH2 + O2 = 6-dehydro-D-glucose + FMN + 2 H(+) + H2O + sulfite", "d": []}, {"i": "EC:1.14.14.181", "l": "\"sulfoquinovose monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42450", "l": "(2E)-glutaconyl-CoA + H2O => (R)-2-hydroxyglutaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67380", "l": "H2O + L-alanyl-L-cysteine = L-alanine + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63805", "l": "GDP-beta-L-gulose => GDP-beta-L-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042602", "l": "riboflavin reductase (NADPH) activity", "d": ["Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44004", "l": "3-methyl fatty acid + ATP + CoA = a 3-methyl fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205115", "l": "NGF:p75NTR complex binds to NRAGE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43664", "l": "ATP + hydrogencarbonate + tetracosanoyl-CoA = 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694428", "l": "LMAN family proteins bind glycosylated cargo (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373087", "l": "Receptor CCR6 binds CCL20 ligand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39984", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51658", "l": "keto-D-fructuronate => keto-D-tagaturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210290", "l": "Interaction of PECAM-1 and SHIP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12396", "l": "dTDP-D-galactose + H2O + 2 NADP(+) = dTDP-D-galacturonate + 3 H(+) + 2 NADPH", "d": []}, {"i": "EC:1.1.1.186", "l": "\"dTDP-galactose 6-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60583", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692755", "l": "CDK1 phosphorylates MAPK6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29733", "l": "beta-maltose(out) => beta-maltose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45345", "l": "globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => globoside NORint (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382058", "l": "Nck binds to the active PDGF receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26275", "l": "Co-precorrin-4 + S-adenosyl-L-homocysteine => Co-precorrin-3 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47439", "l": "(2E,7Z)-hexadecadienoyl-CoA + H2O <=> (3S)-hydroxy-(7Z-hexadecenoyl)-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937792", "l": "RUNX3 binds SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10434", "l": "acetate + CO2 + NH4(+) + succinate semialdehyde => 2-(acetamidomethylene)succinate + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59656", "l": "D-cellotriose + O2 = D-cellotriono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811508", "l": "ING2-bound EP300 acetylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102167", "l": "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity", "d": ["Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-L-serine-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [protein]-L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976768", "l": "Factor H binds to C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37111", "l": "(15Z)-tetracosenoyl-CoA + sphing-4-enine = CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13583", "l": "H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP => N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39816", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate => (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875183", "l": "CBL monoubiquitinates activated MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9692867", "l": "HRH3 binds pitosilant (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34563", "l": "CDP-alpha-D-abequose + NADP(+) = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.341", "l": "\"CDP-abequose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649735", "l": "Intrinsic nucleotide exchange on RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67045", "l": "A + asnovolin H => AH2 + chermesin D", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015389", "l": "pyrimidine- and adenosine-specific:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenosine)(out) + Na+(out) = (pyrimidine nucleoside or adenosine)(in) + Na+(in)."]}, {"i": "TCDB:2.A.41.2.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373075", "l": "Metabotropic glutamate receptors bind glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56210", "l": "3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41325", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2752115", "l": "SPP1 (osteopontin) binds CD44 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50389", "l": "5a,11a-dehydrotetracycline + H(+) + NADPH + O2 => 5a,11a-dehydrooxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11706", "l": "CO2 + N-(aminomethyl)urea => 2 H(+) + N-(carboxyaminomethyl)urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012186", "l": "CHD1 translation is negatively regulated by miR-26A and B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030331", "l": "nuclear estrogen receptor binding", "d": ["Binding to a nuclear estrogen receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20260", "l": "3-methyloxindole + NADP(+) <=> 3-methyleneoxindole + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19459", "l": "catechol + H2O + 2 NADP(+) + nitrite => 2-nitrophenol + 2 H(+) + 2 NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73646", "l": "CTP(out) + IDP(in) <=> CTP(in) + IDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64222", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine => H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.240751554780076", "identifiers": [{"i": "GO:0042923", "l": "neuropeptide binding", "d": ["Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32274", "l": "(2R,3S)-3-isopropylmalate + NAD(+) <=> 4-methyl-2-oxopentanoate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43960", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63951", "l": "H2O + sphinga-4E,14Z-dienine-1-phosphate <=> phosphate + sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62172", "l": "an N-acylethanolamine phosphate + H2O = an N-acylethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43186", "l": "H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2843) in 25S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32194", "l": "H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48570", "l": "(2E,4Z)-2-chloromuconate + 2 H(+) => 3-chlorocatechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43814", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391939", "l": "TP receptor can bind thromboxane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38132", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol => 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36987", "l": "CMP + phosphate = alpha-D-ribose 1,5-bisphosphate + cytosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59807", "l": "L-phenylalanine <=> D-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13799", "l": "di-trans,poly-cis-dolichol + phosphate => a dolichyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762246", "l": "ANGPTL4 binds CDH11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64166", "l": "formaldehyde + L-alanine => 2-methyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14643", "l": "biuret + CO2 => cyanurate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47049", "l": "a quinone + shikimate => 3-dehydroshikimate + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791095", "l": "Expression of HERPUD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50694", "l": "ADP + alpha-maltose 1-phosphate + H(+) => ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53682", "l": "2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30206", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate <=> 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66568", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O = preluffariellolide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40390", "l": "1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP <=> 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12465", "l": "myo-inositol + UDP-alpha-D-galactose => alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351948", "l": "Mitochondrial recruitment of Drp1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47706", "l": "cytochalasin Z16 + H2O + NADP(+) => H(+) + iso-precytochalasin + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64973", "l": "dUDP + H2O => dUMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034520", "l": "2-naphthaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607733", "l": "BCL10 binds CARD9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15781", "l": "L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate", "d": []}, {"i": "EC:5.4.3.6", "l": "\"tyrosine 2,3-aminomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218832", "l": "CDC42:GTP binds PAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036423", "l": "hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity", "d": ["Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + all-trans-hexaprenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52461", "l": "17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9718020", "l": "PTGFR binds PTGFR agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351207", "l": "Spermine  => N-acetylated spermine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20816", "l": "3alpha-hydroxyglycyrrhetinate + NADP(+) = 3-oxoglycyrrhetinate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.230", "l": "\"3alpha-hydroxyglycyrrhetinate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44826", "l": "a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.2.4", "l": "\"purine imidazole-ring cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809707", "l": "MTMR12 binds MTMR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24396", "l": "scytalone = 1,3,8-trihydroxynaphthalene + H2O", "d": []}, {"i": "EC:4.2.1.94", "l": "\"scytalone dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53924", "l": "a secondary amine + S-adenosyl-L-methionine = a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75850", "l": "Addition of the third nucleotide on the nascent transcript (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420975", "l": "Ca impermeable AMPA receptor ligand binding (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016517", "l": "interleukin-12 receptor activity", "d": ["Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102556", "l": "dammarenediol 12-hydroxylase activity", "d": ["Catalysis of the reaction: dammarenediol-II + NADPH + H+ + O2 <=> (20S)-protopanaxadiol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9615348", "l": "AGT(34-41) binds to AGTR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782943", "l": "UV-DDB ubiquitinates XPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11099", "l": "NADP(+) + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867047", "l": "PTPN3 dephosphorylates EPS15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33258", "l": "2-demethylmenaquinol-7 + S-adenosyl-L-methionine <=> H(+) + menaquinol-7 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050016", "l": "kynurenine 7,8-hydroxylase activity", "d": ["Catalysis of the reaction: kynurenate + donor-H2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008534", "l": "oxidized purine nucleobase lesion DNA N-glycosylase activity", "d": ["Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54016", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37738", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374681", "l": "L1 and NCAM1 engaged in cis-interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62471", "l": "3,4-dihydroxybenzoate + ATP + H(+) <=> 3,4-dihydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13732", "l": "FAD <=> AMP + H(+) + riboflavin cyclic-4',5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36561", "l": "4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+) => A + cis-4-hydroxy-D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69921", "l": "inosine(in) + 2 Na(+)(in) => inosine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58390", "l": "4-amino-3-all-trans-hexaprenylbenzoate + diphosphate => 4-aminobenzoate + all-trans-hexaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112150", "l": "RNA Polymerase III Promoter Opening at Type 2 Promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.104", "l": "\"mannan-binding lectin-associated serine protease-2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10685", "l": "H2O + O-phospho-L-tyrosyl-[protein] => L-tyrosyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38832", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211924", "l": "CYP4B1 12-hydroxylates ARA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75050", "l": "N(omega),N(omega)-dimethyl-L-arginine(out) <=> N(omega),N(omega)-dimethyl-L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450975", "l": "isocitrate <=> citrate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.-.-", "l": "\"Acting on peptide bonds (peptidases)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11756", "l": "ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": []}, {"i": "EC:6.3.4.15", "l": "\"biotin--[biotin carboxyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201457", "l": "BMP2 binds to the receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420274", "l": "GIP receptor binds gastric inhibitory peptide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67776", "l": "a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H2O = a 5'-end dephospho-2'-deoxyribonucleoside-DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389026", "l": "Galanin receptors can bind galanin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74714", "l": "5-dehydro-6-demethoxy-6-hydroxyfumagillol + S-adenosyl-L-methionine <=> 5-dehydrofumagillol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102916", "l": "sesamin synthase activity", "d": ["Catalysis of the reaction: H+ + (+)-piperitol + NADPH + O2 <=> (+)-sesamin + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327746", "l": "FN1 aggregation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849878", "l": "PSD-95 binds NMDA receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19247", "l": "2-aminophenol => N-phenylhydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874718", "l": "TTPA binds alpha-TOH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10554", "l": "2-dehydro-D-glucose + H2O2 => D-glucose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-507719", "l": "p62:MEKK3 binds to TRAF6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72400", "l": "2-oxoglutarate(out) + estrone 3-sulfate(in) => 2-oxoglutarate(in) + estrone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18563", "l": "4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186798", "l": "GAP binds to PDGF-beta receptors only (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052897", "l": "N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity", "d": ["Catalysis of the reaction: H2O + N(8)-acetylspermidine + O2 = 1,3-diaminopropane + 4-acetamidobutanal + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43448", "l": "H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013361", "l": "NEXT3 is cleaved to produce NICD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0030955", "l": "potassium ion binding", "d": ["Binding to a potassium ion (K+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64273", "l": "benzylamine + pyruvate => benzaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.213", "l": "\"3alpha-hydroxysteroid dehydrogenase (Re-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23596", "l": "H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate", "d": []}, {"i": "EC:1.1.1.22", "l": "\"UDP-glucose 6-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018839", "l": "cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity", "d": ["Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23954", "l": "2-phenylethylamine + acetate => H2O + N-(2-phenylethyl)acetamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73066", "l": "H(+)(out) + Mn(2+)(in) <=> H(+)(in) + Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54204", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11309", "l": "acetyl-CoA + ATP + hydrogencarbonate => ADP + H(+) + malonyl-CoA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211224", "l": "Association of DFF40 with DFF45 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52709", "l": "GMP + H2O => D-ribose 5-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49632", "l": "(2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate = (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33567", "l": "A + ethanol = acetaldehyde + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21838", "l": "2-dehydro-3-deoxy-D-arabinonate + H2O => D-arabinonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395992", "l": "p-T,4S-IRF3 is dimerized (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54649", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205118", "l": "TRAF6 polyubiquitinates NRIF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12918", "l": "3alpha(S)-strictosidine + H2O => D-glucose + strictosidine aglycone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73451", "l": "adenosine 3',5'-bisphosphate(in) + AMP(out) = adenosine 3',5'-bisphosphate(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52376", "l": "(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) = (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29303", "l": "2 H(+)(in) + succinate(in) = 2 H(+)(out) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39133", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052762", "l": "gellan lyase activity", "d": ["Catalysis of the reaction: gellan = n beta-D-4-deoxy-delta4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp. This reaction is the eliminative cleavage of beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyluronate bonds of gellan backbone, releasing tetrasaccharides containing a 4-deoxy-4,5-unsaturated D-glucopyranosyluronic acid at the non-reducing end; in the product, the abbreviations are D-glucose (Glc), D-glucuronic acid (GlcA), and L-rhamnose (Rha)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237129", "l": "Acireductone is created (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17359", "l": "H2O2 + R'C(R)S-S(R)CR' => O2 + 2 R'C(R)SH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012689", "l": "IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57022", "l": "ADP + apulose 4-phosphate + H(+) => apulose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761065", "l": "FOXF1 binds CDH11 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58800", "l": "3',3'-cGAMP + H2O = 5'-pApG-3' + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33632", "l": "ATP + CoA + octanoate => AMP + diphosphate + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60618", "l": "ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate => N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67200", "l": "H2O + N-acetyltyramine = acetate + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15547", "l": "acetate + pyruvate => (3S)-citramalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811479", "l": "ING2 recruits EP300 to TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28218", "l": "chloride + H(+) + H2O2 = H2O + hypochlorous acid", "d": []}, {"i": "EC:1.11.2.2", "l": "\"myeloperoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28719", "l": "adenine(in) + H(+)(in) = adenine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725357", "l": "NPM-ALK-dependent CEBPB gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2394007", "l": "PI3K gain of function mutants phosphorylate PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912734", "l": "CBL:CRKL binds RAPGEF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789109", "l": "Superoxide anion reacts with Fe-S cluster (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19062", "l": "H2O + NADP(+) + nitrite => H(+) + NADPH + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647746", "l": "EML4 trimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21573", "l": "3-hydroxy-2-methyl-1H-quinolin-4-one + O2 => CO + H(+) + N-acetylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59213", "l": "holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP => AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209220", "l": "Liberation of CI from SU(FU) repression (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38980", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1980122", "l": "DTX binds NOTCH1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40892", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322431", "l": "XIAP binds TLE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17974", "l": "diphosphate + IMP => 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30659", "l": "4-(phosphooxy)-L-threonine + H2O = 4-hydroxy-L-threonine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50451", "l": "AH2 + prostaglandin G3 <=> A + H2O + prostaglandin H3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58189", "l": "all-trans-lycopene + dimethylallyl diphosphate + H2O => dihydroisopentenyldehydrorhodopin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943279", "l": "GGT dimers hydrolyse GSH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388833", "l": "Phosphorylation of CTLA-4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0044374", "l": "sequence-specific DNA binding, bending", "d": ["The activity of binding selectively and non-covalently to DNA in a sequence-specific manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964280", "l": "Active Gq binds BTK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36383", "l": "carbamoyl adenylate + tobramycin = AMP + H(+) + nebramycin 5'", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67749", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26126", "l": "(S)-1-pyrroline-5-carboxylate + FADH2 => FAD + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9671145", "l": "DKC1 binds SHQ1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9619355", "l": "CaMKK autophosphorylates in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73729", "l": "Formation of SL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228940", "l": "Transcytosis and dissociation of botB:NTNHA:HA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9640195", "l": "RRAGA,B hydrolyzes GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67277", "l": "H2O + hexanal + NAD(+) => 2 H(+) + hexanoate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49090", "l": "FADH2 + hydroxysqualene => FAD + H(+) + H2O + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865320", "l": "CBFB binds RUNX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23882", "l": "N(pros)-phospho-L-histidyl-[protein] + pyruvate => L-histidyl-[protein] + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55288", "l": "tetradecan-1-ol + tetradecanoyl-CoA = CoA + tetradecanyl tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203700", "l": "eNOS translocation from Golgi to Caveolae (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70055", "l": "AH2 + cremeomycin = 2-hydroxy-4-methoxybenzoate + A + N2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68396", "l": "a percarboxylic acid + H2O = a carboxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19284", "l": "(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] <=> acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432067", "l": "Aquaporin-4 passively transports water out of cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853792", "l": "RET tyrosine phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45954", "l": "H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP => L-asparaginyl-[protein] + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761830", "l": "NFE2L2 binds the TALDO1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64978", "l": "8-oxo-dGMP + 2 H(+) + 2 phosphate => 8-oxo-dGTP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.20.14", "l": "\"hapalindole-type alkaloid chlorinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1011598", "l": "DOCKs bind to RhoGEFs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65560", "l": "2-oxoglutarate + L-kynurenine = H2O + kynurenate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57019", "l": "3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9623384", "l": "α1-agonists bind ADRA1A,B,D (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47479", "l": "(3E)-tetradecenoyl-CoA <=> (2E)-tetradecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41038", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052680", "l": "epi-isozizaene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990593", "l": "nascent polypeptide-associated complex binding", "d": ["Binding to nascent polypeptide-associated complex, a heterodimeric protein complex that can reversibly bind to ribosomes and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62378", "l": "(S)-lactate + H(+) + pyruvate => 2,4-didehydro-3-deoxy-L-rhamnonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52117", "l": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA => 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004015", "l": "adenosylmethionine-8-amino-7-oxononanoate transaminase activity", "d": ["Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030791", "l": "arsenite methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68154", "l": "a triacylglycerol + CoA => a 1,3-diacylglycerol + a fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10951", "l": "ATP + D-glucosamine <=> ADP + D-glucosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814764", "l": "Plasma membrane resorption (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59091", "l": "D-histidine + S-adenosyl-L-methionine <=> (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626034", "l": "EEF1A1 dissociates from p-GFAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49025", "l": "L-tryptophan + O2 => 2-iminio-3-(indol-3-yl)propanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16543", "l": "(3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin => 9-cis-violaxanthin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685011", "l": "ATR activation at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38478", "l": "L-histidine + S-adenosyl-L-methionine <=> H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.25", "l": "\"shikimate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042834", "l": "peptidoglycan binding", "d": ["Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62389", "l": "[(1->2)-beta-D-glucosyl](n) + H2O => [(1->2)-beta-D-glucosyl](n-2) + sophorose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061953", "l": "mRNA (adenine-N1-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine in mRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83788", "l": "Binding of TFIIIC to Type 2 promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317530", "l": "SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782685", "l": "EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427570", "l": "Group 3 - Selective Cl- transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014294", "l": "RAC2 binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182986", "l": "CBL-mediated ubiquitination of CIN85 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102033", "l": "long-chain fatty acid omega-hydroxylase activity", "d": ["Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71146", "l": "3-hydroxyhispidin + O2 <=> (E)-caffeoylpyruvate + CO2 + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034573", "l": "didemethylisoproturon amidohydrolase activity", "d": ["Catalysis of the reaction: didemethylisoproturon + H2O = carbamic acid + 4-isopropylaniline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853762", "l": "RET dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237119", "l": "Acireductone is oxidized to MOB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1297275", "l": "CD9:Izumo Binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047464", "l": "heparosan-N-sulfate-glucuronate 5-epimerase activity", "d": ["Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39317", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052656", "l": "L-isoleucine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12767", "l": "acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74515", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B = aspoquinolone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45208", "l": "coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein] = Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}, {"i": "EC:2.1.1.246", "l": "\"[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17330", "l": "(1R,2S,4R)-borneol + NAD(+) => (1R,4R)-camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613023", "l": "NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15946", "l": "aldehydo-D-glucose 6-phosphate + L-lysyl-[protein] => H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603791", "l": "PEX16:PEX19:PEX3 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56977", "l": "4-methylphenol + H2O + 2 oxidized [azurin] => 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103031", "l": "L-Ala-D/L-Glu epimerase activity", "d": ["Catalysis of the reaction: L-alanyl-D-glutamate = L-alanyl-L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65299", "l": "(2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052728", "l": "capsorubin synthase activity", "d": ["Catalysis of the reaction: violaxanthin = capsorubin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611839", "l": "β3-agonists bind ADRB3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20158", "l": "a polyvinyl alcohol + 2n Fe(III)-[cytochrome c] => an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850945", "l": "Casein kinase II phosphorylates PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37774", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75702", "l": "2 glutathione + NAD(+) <=> glutathione disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391939", "l": "TP receptor can bind thromboxane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201629", "l": "Caspase-mediated cleavage of Tau (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32855", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63482", "l": "15-oxoprostaglandin F2alpha + H(+) + NADPH => NADP(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20386", "l": "(2R,3R)-dihydroquercetin + H(+) + NADH + O2 => (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23652", "l": "N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)", "d": []}, {"i": "EC:2.3.2.5", "l": "\"glutaminyl-peptide cyclotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22208", "l": "3-hydroxyphenylacetate + H(+) + NADH + O2 = H2O + homogentisate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183072", "l": "EGFR non-clathrin mediated endocytosis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9035484", "l": "CysS248-MPST:TXN2 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18574", "l": "dihydrochelirubine + H(+) + O2 => chelirubine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31192", "l": "(3S)-hydroxydecanoyl-CoA => (2E)-decenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66408", "l": "ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O = ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68240", "l": "L-methionine(in) + Na(+)(in) = L-methionine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77081", "l": "Formation of the CE:GMP intermediate complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51988", "l": "(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O = 18S-resolvin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52534", "l": "AMP + GDP + H(+) => adenosine + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666435", "l": "VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35422", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63850", "l": "2 3',4'-dihydroxyaurone + 2 H2O => 2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375395", "l": "C5a receptor binds C5a anaphylatoxin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19916", "l": "a (3R)-hydroxyacyl-[ACP] + NAD(+) <=> a 3-oxoacyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54326", "l": "a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin] => a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218821", "l": "PDK1 phosphorylates PKC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191654", "l": "c-src associates with Cx43 in gap junctions (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38530", "l": "1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30170", "l": "D-erythrose 4-phosphate + dihydroxyacetone phosphate <=> D-sedoheptulose 1,7-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62817", "l": "4 monapinone E + O2 => 2 dinapinone E + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32104", "l": "2 S-adenosyl-L-methionine + trans-resveratrol => 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13000", "l": "(E)-feruloyl-CoA + galactarate <=> 2-O-[(E)-feruloyl]-D-galactarate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72691", "l": "Formation of the 43S pre-initiation complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112395", "l": "Abortive termination of elongation after arrest (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791016", "l": "SFTPB binds itself (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050062", "l": "long-chain-fatty-acyl-CoA reductase activity", "d": ["Catalysis of the reaction: a long-chain fatty aldehyde + CoA + NADP+ = a long-chain fatty acyl-CoA + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36276", "l": "H(+) + NADPH + O2 + theophylline => 3-methylxanthine + formaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854466", "l": "VLDLR binds RELN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0030599", "l": "pectinesterase activity", "d": ["Catalysis of the reaction: pectin + n H2O = n methanol + pectate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23574", "l": "3 CO2 + 4 CoA + phlorisovalerophenone => 3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102371", "l": "betulin dehydrogenase activity", "d": ["Catalysis of the reaction: betulin + NADPH(4-) + H+ + O2 <=> betulinic aldehyde + NADP(3-) + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73793", "l": "diphosphate + variecolorin G => dimethylallyl diphosphate + neoechinulin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614591", "l": "Excess cysteine yields lanthionine and H2S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102186", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NADH(2-) + O2 <=> 4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40860", "l": "(9Z)-hexadecenoyl-CoA + FAD + H(+) => (2E,9Z)-hexadecadienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21108", "l": "(S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44535", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64304", "l": "1-phenylpropylamine + pyruvate = 1-phenylpropan-1-one + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44486", "l": "3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9663511", "l": "BIL binds GSTA1, FABP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014296", "l": "RAC2 GEFs activate RAC2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9688838", "l": "RIPK3 binds STUB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22115", "l": "isoxazolin-5-one + O-acetyl-L-serine <=> 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102247", "l": "malonyl-malonyl acyl carrier protein-condensing enzyme activity", "d": ["Catalysis of the reaction: 2 H+ + 2 a malonyl-[acp] <=> 2 carbon dioxide + an acetoacetyl-[acp] + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55745", "l": "coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51371", "l": "glycine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63464", "l": "(2E,6E,10E)-geranylgeraniol + UTP = (2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18117", "l": "L-tyrosine + O2 = H2O + L-dopaquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39694", "l": "(2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH <=> (11Z)-octadecenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483087", "l": "PI is exchanged with PC by PITPNB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928576", "l": "RHOA:GTP binds ROCK, activating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65173", "l": "(3Z,5E)-dodecadienoyl-CoA + H2O => (3Z,5E)-dodecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40360", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38169", "l": "CoA + hexadecanyl hexadecanoate => hexadecan-1-ol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52001", "l": "a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + glutathione => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32016", "l": "(2E,6E)-farnesyl diphosphate => (-)-delta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40153", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+) => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617595", "l": "SGTA binds mislocalized membrane protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.19", "l": "\"taxifolin 8-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047879", "l": "erythronolide synthase activity", "d": ["Catalysis of the reaction: 6 malonyl-CoA + propionyl-CoA = 7 CoA + 6-deoxyerythronolide B."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9646685", "l": "Aggresome dissociates from dynein and microtubule (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042901", "l": "arabinan transmembrane transporter activity", "d": ["Enables the transfer of an arabinan, a polysaccharide composed of arabinose residues, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74541", "l": "creatinine(out) => creatinine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507873", "l": "Aquaporins passively transport urea out of cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052857", "l": "NADPHX epimerase activity", "d": ["Catalysis of the reaction: (R)-NADPHX = (S)-NADPHX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15410", "l": "1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine => 1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18281", "l": "NAD(+) + succinate = fumarate + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.6", "l": "\"fumarate reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35121", "l": "bisdemethoxycurcumin + CO2 + 2 CoA => (4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34004", "l": "5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 => 7-dehydrodesmosterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14753", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27840", "l": "2'-aminobiphenyl-2,3-diol + NAD(+) => 9H-carbazole + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54995", "l": "3 A + FMN + H2O + L-glutamate + O2 <=> 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9680443", "l": "ROCK1,2 bind ROCKi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981621", "l": "Neuroglobin:oxygen dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112042", "l": "Opioid binds MOR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683925", "l": "ULK1 is dephosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25467", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + longifolene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53152", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60444", "l": "an S-substituted L-cysteinylglycine + H2O = an S-substituted L-cysteine + glycine", "d": []}, {"i": "EC:3.4.13.23", "l": "\"cysteinylglycine-S-conjugate dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60460", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662618", "l": "MT1G binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65259", "l": "AH2 + O2 + verruculide C <=> A + H2O + verruculide C epoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63047", "l": "H2O + mevastatin <=> H(+) + mevinic carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004798", "l": "thymidylate kinase activity", "d": ["Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43346", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805640", "l": "AKT phosphorylates KAT6A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42647", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] <=> diphosphate + holo-[malonate decarboxylase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.062476272212777", "identifiers": [{"i": "GO:0016763", "l": "pentosyltransferase activity", "d": ["Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23862", "l": "cephalosporin C + CoA => acetyl-CoA + deacetylcephalosporin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388811", "l": "CD28 homodimer binds B7-1 homodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68277", "l": "butanoyl-CoA + L-seryl-[protein] => CoA + O-butanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60402", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102807", "l": "cyanidin 3-O-glucoside 2''-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-O-beta-D-glucoside betaine <=> cyanidin 3-O-sophoroside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52394", "l": "4-phospho-D-erythronate + ADP + H(+) => ATP + D-erythronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404193", "l": "IGF1R phosphorylates SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44858", "l": "CoA + O-(9Z)-octadecenoyl-(R)-carnitine => (9Z)-octadecenoyl-CoA + (R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53495", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) <=> 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625124", "l": "GCK gene expression is inhibited by FOXO1, SIN3A and HDACs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070996", "l": "type 1 melanocortin receptor binding", "d": ["Binding to a type 1 melanocortin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69116", "l": "Formation of Okazaki fragments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28621", "l": "2-methylbutyronitrile + H(+) + NADPH + O2 <=> 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32887", "l": "all-trans-beta-carotene + O2 = 2 all-trans-retinal", "d": []}, {"i": "EC:1.13.11.63", "l": "\"beta-carotene 15,15'-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47598", "l": "an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP => an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18180", "l": "a 2,3-saturated acyl-CoA + NAD(+) <=> a (2E)-enoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0070815", "l": "peptidyl-lysine 5-dioxygenase activity", "d": ["Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 5-hydroxy-L-lysine + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21553", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36852", "l": "(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42049", "l": "3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75530", "l": "(R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMNH2 + O2 <=> benzaldehyde + FMN + H(+) + H2O + N-acetyl-S-hydroxy-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004502", "l": "kynurenine 3-monooxygenase activity", "d": ["Catalysis of the reaction: L-kynurenine + H+ + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46407", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36369", "l": "2-hydroxyglutarate + H(+) => (S)-alpha-hydroxyglutarate-gamma-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034521", "l": "1-naphthoic acid dioxygenase activity", "d": ["Catalysis of the reaction: 1-naphthoic acid + NADH + O2 + H+ = cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16984", "l": "3-oxoadipate + NAD(+) <=> H(+) + maleylacetate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046564", "l": "oxalate decarboxylase activity", "d": ["Catalysis of the reaction: H+ + oxalate = CO2 + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0030366", "l": "molybdopterin synthase activity", "d": ["Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59608", "l": "beta-alanyl-L-lysine + H2O = beta-alanine + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.13", "l": "\"manganese peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000210", "l": "NAD+ diphosphatase activity", "d": ["Catalysis of the reaction: NAD+ + H2O = AMP + NMN."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42815", "l": "cholesterol + octadecanoyl-CoA <=> cholesteryl octadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39143", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49283", "l": "FADH2 + O2 + phenol <=> catechol + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085992", "l": "SUMOylation of DAXX with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20907", "l": "(S)-2-hydroxypropyl-coenzyme M <=> (S)-1,2-epoxypropane + coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42950", "l": "5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1006143", "l": "CD46 binds C3b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801675", "l": "PLK2 phosphorylates NPM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196026", "l": "Dab2 is recruited to the junctional plaques (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66731", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in) <=> ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68968", "l": "mandelate + O2 = H2O2 + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110011", "l": "Binding of Grb10 to the insulin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34426", "l": "(-)-secoisolariciresinol + NADP(+) <=> (+)-lariciresinol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34994", "l": "L-arginine(out) + L-ornithine(in) <=> L-arginine(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052679", "l": "terpentetriene synthase activity", "d": ["Catalysis of the reaction: terpentedienyl diphosphate = diphosphate + terpentetriene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73191", "l": "(2R,3S,11R)-aszonalenin + acetyl-CoA = (2R,3S,11R)-acetylaszonalenin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25540", "l": "ent-copalyl diphosphate = diphosphate + ent-pimara-8(14),15-diene", "d": []}, {"i": "EC:4.2.3.30", "l": "\"ent-pimara-8(14),15-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68744", "l": "2 (R)-3-phenyllactate + 2 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022A + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19187", "l": "2-hydroxyglutarate + CoA + H(+) => glyoxylate + H2O + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080012", "l": "trihydroxyferuloyl spermidine O-methyltransferase activity", "d": ["Catalysis of the reaction: trihydroxyferuloyl spermidine + S-adenosyl-L-methionine = dihydroxyferuloyl-sinapoyl spermidine + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45714", "l": "acetyl-CoA + N,N,N-trimethylglycyl-CoA => 3-dehydrocarnityl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705584", "l": "HMGCR dimer binds statins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10878", "l": "CO2 + phenol => 4-hydroxybenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14366", "l": "2 H(+) + H2O + N-carbamoyl-L-aspartate => CO2 + L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51052", "l": "5alpha-androstan-3,17-dione + A = 5alpha-androst-1-ene-3,17-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211968", "l": "CYP2W1 oxidises INDOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663165", "l": "p-BMAL1:p-CLOCK,NPAS2 binds AVP gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71804", "l": "acetate(out) + H(+)(out) => acetate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67184", "l": "(glycyl)(n)-glycyl-L-glutamyl-[protein] + ATP + glycine = (glycyl)(n+1)-glycyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9022314", "l": "HIPK2 phosphorylates MECP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67192", "l": "ATP + H2O + N-11-cis-retinylidenephosphatidylethanolamine(out) = ADP + H(+) + N-11-cis-retinylidenephosphatidylethanolamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21537", "l": "(3S)-hydroxy-3-methylglutaryl-CoA => 3-methyl-(2E)-glutaconyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30481", "l": "2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase] => L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9646468", "l": "mTORC1 binds RHEB:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034564", "l": "4,4'-dihydroxy-alpha-methylstilbene dioxygenase activity", "d": ["Catalysis of the reaction: 4,4'-dihydroxy-alpha-methylstilbene + O2 = 4-hydroxybenzaldehyde + 4-hydroxyacetophenone + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69801", "l": "D-tryptophan + tRNA(Trp) => D-tryptophanyl-tRNA(Trp) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17004", "l": "amidinoproclavaminate + H2O <=> proclavaminate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-500708", "l": "GRIK3 homomer binds glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264865", "l": "Caspase-mediated cleavage of Lamin A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59071", "l": "demethyldeoxyspectinabilin + S-adenosyl-L-methionine <=> deoxyspectinabilin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109862", "l": "MAP2K2 phosphorylates MAPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46629", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH => androst-5-en-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418850", "l": "Activation of Cdc42 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13399", "l": "2 H(+) + hexanedioate + NADPH => 6-oxohexanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16757", "l": "NADP(+) + trypanothione = H(+) + NADPH + trypanothione disulfide", "d": []}, {"i": "EC:1.8.1.12", "l": "\"trypanothione-disulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63859", "l": "O2 + tetradecanoate <=> (2R)-2-hydroperoxytetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58162", "l": "diphosphate + dolabradiene => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32960", "l": "H2O + L-isoleucine + NAD(+) => (S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190258", "l": "FGFR2c binds to FGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.11", "l": "\"Xaa-Pro dipeptidyl-peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40331", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5615668", "l": "AKR1C3 reduces atRAL to atROL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65666", "l": "citrate(in) + 4 Na(+)(in) => citrate(out) + 4 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47896", "l": "6-sulfo-D-quinovose + NAD(+) = 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.390", "l": "\"sulfoquinovose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29513", "l": "(+)-valencene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61258", "l": "2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+) => H2O + L-cysteine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928640", "l": "PAKs phosphorylate MLC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786190", "l": "CMBL hydrolyses OM to OLMS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853915", "l": "VENTX binds the TP53 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32912", "l": "sn-glycerol 3-phosphocholine(out) => sn-glycerol 3-phosphocholine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507869", "l": "Aquaporins passively transport glycerol into cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36307", "l": "(E)-caffeoyl-CoA + H2O = 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61143", "l": "(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + myricetin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710468", "l": "GSDME variant does not bind PIPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097718", "l": "disordered domain specific binding", "d": ["Binding to a disordered domain of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45949", "l": "acetyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35664", "l": "a 1,2-diacyl-sn-glycerol + H2O => a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36652", "l": "8-desmethylnovobiocic acid + S-adenosyl-L-methionine => H(+) + novobiocic acid + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37327", "l": "ATP + H2O + L-methionyl-L-alanine(out) = ADP + H(+) + L-methionyl-L-alanine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047229", "l": "13-hydroxydocosanoate 13-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: 13-hydroxydocosanoate + UDP-D-glucose = 13-beta-D-glucosyloxydocosanoate + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001849", "l": "complement component C1q complex binding", "d": ["Binding to a C1q complex, a component of the classical complement cascade."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22388", "l": "acetyl-CoA + N(6)-hydroxy-L-lysine = CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": []}, {"i": "EC:2.3.1.102", "l": "\"N(6)-hydroxylysine O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49459", "l": "(2S)-2-amino-4-deoxychorismate + H2O <=> (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350651", "l": "Caspase-mediated cleavage of MASK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602186", "l": "Defective CYP27B1 does not hydroxylate CDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69300", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate = benzyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821486", "l": "HCFC1 binds SET1A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25512", "l": "(2S)-2-amino-4-deoxychorismate + L-glutamate = chorismate + L-glutamine", "d": []}, {"i": "EC:2.6.1.86", "l": "\"2-amino-4-deoxychorismate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371422", "l": "ATP hydrolysis by HSP70 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102749", "l": "dihydrogeranylgeranyl-chlorophyll a reductase activity", "d": ["Catalysis of the reaction: H+ + dihydrogeranylgeranyl-chlorophyll a + NADPH = tetrahydrogeranylgeranyl-chlorophyll a + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72596", "l": "H(+)(out) + N-acetyl-L-aspartyl-L-glutamate(out) => H(+)(in) + N-acetyl-L-aspartyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37098", "l": "(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605723", "l": "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75183", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + lydicene", "d": []}, {"i": "EC:4.2.3.210", "l": "\"lydicene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43899", "l": "3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19630", "l": "D-threo-isocitrate + NADP(+) => 2-oxoglutarate + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801666", "l": "PLK2 phosphorylates CENPJ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47893", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9815510", "l": "MIB2 binds CYLD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29928", "l": "(R)-pantothenate(in) + Na(+)(in) => (R)-pantothenate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938356", "l": "RMB14 binds RUNX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052927", "l": "CTP:tRNA cytidylyltransferase activity", "d": ["Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3' CC end + 2 diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694331", "l": "nsp3-4 is glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191830", "l": "snRNP nuclear import and release (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202203", "l": "Recruitment of PI3K to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010331", "l": "gibberellin binding", "d": ["Binding to a gibberellin, a plant hormone that regulates aspects of plant growth."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58153", "l": "H2O + NAD(+) + phosphonoacetaldehyde => 2 H(+) + NADH + phosphonoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36205", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46345", "l": "propanoyl-CoA + tetradecanoyl-CoA => 3-oxo-2-methylhexadecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.843050782660015", "identifiers": [{"i": "GO:0008188", "l": "neuropeptide receptor activity", "d": ["Combining with a neuropeptide to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37228", "l": "(E,E)-sorbate + H(+) => (E)-1,3-pentadiene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30431", "l": "(S)-2,3-epoxysqualene = taraxerol", "d": []}, {"i": "EC:5.4.99.35", "l": "\"taraxerol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24825", "l": "dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102601", "l": "cytochrome P450 dependent beta-amyrin 16beta-hydroxylase activity", "d": ["Catalysis of the reaction: beta-amyrin + O2 + H+ + NADPH = 16beta-hydroxy-beta-amyrin + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5226979", "l": "ADD1:ADD2 binds DMTN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12329", "l": "[(1->3)-alpha-D-glucosyl](n) + phosphate => [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16067", "l": "2-hydroxyphytanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + phytanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381668", "l": "cAMP activates EPAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46444", "l": "(11Z)-hexadecenoyl-CoA + AH2 + O2 = (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": []}, {"i": "EC:1.14.19.15", "l": "\"(11Z)-hexadec-11-enoyl-CoA conjugase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70700", "l": "H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out) => H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41093", "l": "1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052795", "l": "exo-alpha-(2->6)-sialidase activity", "d": ["Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10439", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018804", "l": "RAC3 GEFs activate RAC3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48003", "l": "1,6-dihydro-beta-NADP + H(+) + O2 <=> H2O2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70178", "l": "beta-D-glucosyl-(1->4)-D-galactose + phosphate <=> alpha-D-glucose 1-phosphate + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533944", "l": "Fibronectin degradation by MMP10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41307", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52615", "l": "3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56134", "l": "a thymidine dimer in DNA => (5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66562", "l": "5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+) => (R)-noradrenaline + L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44716", "l": "A + all-trans-4,4'-diapolycopen-4-al + H2O = AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23099", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18577", "l": "3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine = 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.302", "l": "\"3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382058", "l": "Nck binds to the active PDGF receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030746", "l": "isoflavone 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9646468", "l": "mTORC1 binds RHEB:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29221", "l": "a menaquinol + dihydroxyacetone phosphate => a menaquinone + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944246", "l": "Association of procollagen type XXI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193668", "l": "p75NTR and RHOA-GDI interact (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340124", "l": "CSN polymer binds CaPO4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38712", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051871", "l": "dihydrofolic acid binding", "d": ["Binding to dihydrofolic acid, a folic acid in which the bicyclic pteridine structure is in the dihydro, partially reduced form; they are intermediates in folate metabolism and are reduced to their tetrahydro, reduced forms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16057", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}, {"i": "EC:2.4.1.145", "l": "\"alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49784", "l": "chenodeoxycholoyl-CoA + taurine = CoA + H(+) + taurochenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18541", "l": "10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine = dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.119", "l": "\"10-hydroxydihydrosanguinarine 10-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033417", "l": "CUU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CUU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60109", "l": "(R)-3-(4-hydroxyphenyl)lactoyl-CoA => (E)-4-coumaroyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70643", "l": "D-proline(out) + H(+)(out) = D-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938815", "l": "RNF152 polyubiquitinates RRAGA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873921", "l": "Binding of STAT1 to p-IFNGR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68407", "l": "(2R,3S)-iso(homo)2citrate + NAD(+) <=> 2-oxoheptanedioate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17700", "l": "pyridine + thiamine <=> 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42706", "l": "H2O + S-(hercyn-2-yl)-L-cysteine S-oxide => hercynine + L-cysteine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13553", "l": "alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.6", "l": "\"galactokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787737", "l": "CSF3R binds CSF3 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38591", "l": "devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine = chloroorienticin B + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.311", "l": "\"dTDP-epi-vancosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621370", "l": "SYK autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372697", "l": "Crk binding to p130cas (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39884", "l": "dTDP-6-deoxy-alpha-D-allose + NADP(+) => dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419351", "l": "PAF receptor binds platelet activating factor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865994", "l": "GAB1 binds PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39216", "l": "(2E)-hexacosenoyl-CoA + H(+) + NADPH => hexacosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70712", "l": "D-alanine(in) => D-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36338", "l": "D-glucuronate + H2O + NAD(+) <=> D-glucarate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70961", "l": "3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+) => D-tyrosine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23353", "l": "2-oxoglutarate + 4-aminobutanoate => L-glutamate + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174967", "l": "NAT2 acetylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67712", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41066", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443774", "l": "Trans-homodimerization of Neurofascin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782943", "l": "UV-DDB ubiquitinates XPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675206", "l": "PEA15 binds MAPK monomers and dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45229", "l": "a (3E)-enoyl-CoA => a 4-saturated (2E)-enoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950766", "l": "IL27RA dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22724", "l": "a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.173", "l": "\"sterol 3beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19227", "l": "5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin] => glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626549", "l": "IQGAPs bind CALM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51362", "l": "(9Z)-octadecenoate + L-leucine => H2O + N-(9Z-octadecenoyl)-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38851", "l": "H(+) + tetracenomycin F2 = H2O + tetracenomycin F1", "d": []}, {"i": "EC:4.2.1.154", "l": "\"tetracenomycin F2 cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59287", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O <=> D-glucose + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59600", "l": "5-methoxytryptamine + H2O + O2 = 5-methoxyindoleacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60846", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate => a 5'-end diphospho-guanosine in mRNA + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53954", "l": "4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate => 4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19927", "l": "D-ribulose 5-phosphate + H(+) + NADH => D-ribitol 5-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990610", "l": "acetolactate synthase regulator activity", "d": ["Binds to and modulates the activity of acetolactate synthase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68527", "l": "(2Z,6Z)-farnesyl diphosphate <=> beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48591", "l": "2 H2O + 2 leukotriene A4 + O2 <=> 2 lipoxin B4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1170539", "l": "Prolactin receptor is internalized (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29641", "l": "alpha-D-glucose + D-maltopentaose => D-maltohexaose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004996", "l": "thyroid-stimulating hormone receptor activity", "d": ["Combining with thyroid-stimulating hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22625", "l": "(S)-4-hydroxy-2-oxopentanoate => acetaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47558", "l": "deoxycholate + taurine => H2O + taurodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38244", "l": "(9Z)-octadecenoyl-CoA + eicosan-1-ol => 1-O-eicosanyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694345", "l": "Nucleoprotein translocates to the nucleolus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50629", "l": "a 2-(omega-methylsulfanyl)alkylmalate => a 3-(omega-methylsulfanyl)alkylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13996", "l": "(S)-3-amino-2-methylpropanoate + 2-oxoglutarate <=> 2-methyl-3-oxopropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18956", "l": "L-erythro-7,8-dihydrobiopterin + NADP(+) <=> H(+) + NADPH + sepiapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112037", "l": "Inactivation of PLC beta (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10609", "l": "(E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase] => (E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11960", "l": "2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate", "d": []}, {"i": "EC:2.6.1.17", "l": "\"succinyldiaminopimelate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45825", "l": "H(+) + L-serine => CO2 + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30108", "l": "D-serine + NADP(+) => 2-aminomalonate semialdehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67745", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) + H2O => 1-O-alkyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18620", "l": "ATP + oxaloacetate <=> ADP + CO2 + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211405", "l": "Anthrax lef cleaves target cell MAP2K6 (MEK6) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38658", "l": "6-tuliposide B <=> D-glucose + tulipalin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613219", "l": "RRAD gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2574845", "l": "AJUBA binds centrosome-associated AURKA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362437", "l": "C-terminal Hh fragments are bound by lectins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26260", "l": "dehydroabietadienol + H(+) + NADPH + O2 <=> dehydroabietadienal + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46918", "l": "H(+) + juvenile hormone I carboxylate + methanol => H2O + juvenile hormone I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218824", "l": "p-6Y-VEGFR2 binds FYN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43812", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20247", "l": "3''-O-adenylylstreptomycin + diphosphate => ATP + streptomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40766", "l": "(20S)-ginsenoside Re + H2O <=> (20S)-ginsenoside Rg1 + L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676133", "l": "CD74 binds MIF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17319", "l": "chlorophyll a + diphosphate => chlorophyllide a + H(+) + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35830", "l": "H2O + N(1)-aminopropylagmatine <=> spermidine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67364", "l": "H2O + L-threonyl-L-serine = L-serine + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65561", "l": "2-oxoglutarate + L-kynurenine => H2O + kynurenate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55613", "l": "an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + H2O => 1-methyladenine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937792", "l": "RUNX3 binds SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20872", "l": "(20S)-ginsenoside Rd + UDP-alpha-D-glucose = (20S)-ginsenoside Rb1 + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.314", "l": "\"ginsenoside Rd glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2106625", "l": "Duplex siRNA is loaded into Argonaute (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102138", "l": "7-oxatyphasterol synthase activity", "d": ["Catalysis of the reaction: H+ + typhasterol + NADPH + O2 <=> 7-oxatyphasterol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182594", "l": "Association of INK4 family proteins with CDK4/6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12866", "l": "1-methyladenosine + H2O => 1-methyladenine + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102848", "l": "1-18:2-2-18:2-digalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65846", "l": "ADP(in) + H(+)(in) + phosphate(out) => ADP(out) + H(+)(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809663", "l": "Formation of hair keratin fibres (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5666008", "l": "SCAI binds SRF:MKL1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626220", "l": "C2CD3 binds the mother centriole (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162657", "l": "Inactivation of Myt1 kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46096", "l": "3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + dihydropinosylvin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13965", "l": "H2O + L,L-cystathionine = L-homocysteine + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52151", "l": "a (Z)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose <=> an aliphatic (Z)-desulfo-glucosinolate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.135", "l": "\"neopullulanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61049", "l": "lochnericine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917987", "l": "TFRC dimer binds 2xholoTF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35980", "l": "dimethylallyl diphosphate + verruculogen => diphosphate + fumitremorgin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638006", "l": "ARL3 hydrolyzes GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102980", "l": "2-butyl-4-hydroxy-5-methyl-3(2H)-furanoneoxidoreductase activity", "d": ["Catalysis of the reaction: 2-butyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP <=> (2E)-2-butylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74711", "l": "Phosphorylation of IRS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44620", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine = a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34393", "l": "[beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP => beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.14", "l": "\"aromatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295622", "l": "SPRY2 binds CBL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11856", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.62", "l": "\"D-ribose pyranase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75850", "l": "Addition of the third nucleotide on the nascent transcript (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47523", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isolithocholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67081", "l": "a very long-chain fatty acid(in) + ATP + H2O => a very long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14062", "l": "H2O + N-(carboxymethyl)-D-alanine + NAD(+) => glycine + H(+) + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380316", "l": "Association of NuMA with microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70374", "l": "3-oxosphinganine + decanoyl-CoA <=> CoA + H(+) + N-decanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696605", "l": "USP12, USP26 deubiquitinate AR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391934", "l": "DP2 receptor can bind PGD2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32085", "l": "CMP-pseudaminate + diphosphate => CTP + pseudaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380780", "l": "Activation of Src (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17565", "l": "myo-inositol + S-adenosyl-L-methionine = 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.40", "l": "\"inositol 1-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32633", "l": "erythromycin C + H2O + NADP(+) => erythromycin D + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879674", "l": "CD97 binds CD55 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008683", "l": "2-oxoglutarate decarboxylase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + H+ = CO2 + succinate semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20710", "l": "ADP + D-erythritol 4-phosphate + H(+) => ATP + erythritol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56782", "l": "(+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036188", "l": "abieta-7,13-dien-18-al dehydrogenase activity", "d": ["Catalysis of the reaction: abieta-7,13-diene-18-al + H2O + NAD+ = abieta-7,13-diene-18-oate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0000993", "l": "RNA polymerase II complex binding", "d": ["Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48344", "l": "an N-acyl-sphingoid base + UDP-alpha-D-galactose = a D-galactosylceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.77", "l": "\"taurine--pyruvate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928625", "l": "PAKs autophosphorylate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814094", "l": "ARL1:GTP binds ARFIP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004055", "l": "argininosuccinate synthase activity", "d": ["Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13997", "l": "3-methyl-2-oxobutanoate + CoA + NAD(+) = 2-methylpropanoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.62", "l": "\"beta-tubulin-glutamate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015638", "l": "microcin transmembrane transporter activity", "d": ["Enables the transfer of a microcin from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685605", "l": "SLAMF7 binds SLAMF7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49440", "l": "(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA = (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate", "d": []}, {"i": "EC:2.8.3.24", "l": "\"(R)-2-hydroxy-4-methylpentanoate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41834", "l": "hexanoyl-[ACP] + NADP(+) => (2E)-hexenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25898", "l": "acetate + CO2 => H(+) + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44453", "l": "3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35104", "l": "fusidate(in) => fusidate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55623", "l": "a carotenoid psi-end group <=> a carotenoid beta-end derivative", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11653", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose => alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28893", "l": "H(+)(out) + putrescine(out) => H(+)(in) + putrescine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10038", "l": "H2O2 + vanillin => 4-hydroxy-3-methoxy-benzenemethanol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25137", "l": "H2O + pyridoxamine 5'-phosphate => phosphate + pyridoxamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67968", "l": "H2O + presqualene diphosphate = H(+) + phosphate + presqualene monophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111970", "l": "PKC phosphorylates GRK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.21", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102256", "l": "neoagarohexaose 1,3-alpha-3,6-anhydro-L-galactosidase activity", "d": ["Catalysis of the reaction: neoagarohexaose + H2O <=> 3,6-anhydro-alpha-L-galactopyranose + agaropentaose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062204", "l": "(13S)-vitexifolin A synthase activity", "d": ["Catalysis of the reaction:9alpha-copalyl diphosphate + H2O = (13S)-vitexifolin A + diphosphate."]}, {"i": "RHEA:40027", "l": "9alpha-copalyl diphosphate + H2O = (13S)-vitexifolin A + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099534", "l": "calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration", "d": ["The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40182", "l": "decanoyl-CoA + O2 <=> (2E)-decenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047968", "l": "glyoxylate dehydrogenase (acylating) activity", "d": ["Catalysis of the reaction: CoA + glyoxylate + NADP+ = H+ + NADPH + oxalyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029471", "l": "Hydrolysis of PC to PA by PLD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34124", "l": "3,5,7-trioxododecanoyl-CoA => CoA + H(+) + olivetolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210271", "l": "Interaction of DAP12 and MDL-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48587", "l": "2 H2O + 2 leukotriene A4 + O2 <=> 2 lipoxin A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26401", "l": "all-trans-10'-apo-beta-carotenal + O2 = (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone", "d": []}, {"i": "EC:1.13.11.70", "l": "\"all-trans-10'-apo-beta-carotenal 13,14-cleaving dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.509418971541265", "identifiers": [{"i": "GO:0140110", "l": "transcription regulator activity", "d": ["A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54075", "l": "(2E)-geranyl diphosphate <=> beta-thujene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250280", "l": "ROS oxidize thioredoxin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173740", "l": "Factor B binds to C3(H2O) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0004148", "l": "dihydrolipoyl dehydrogenase activity", "d": ["Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34214", "l": "ecgonine methyl ester + NADP(+) <=> ecgonone methyl ester + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62720", "l": "3 H(+) + 3 NADPH + 3 O2 + probetaenone I = betaenone B + 3 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52928", "l": "3',3'-c-di-GMP + 2 H2O = 2 GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72626", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxy-fatty acyl)-sphingoid base <=> a 1,2-diacyl-sn-glycerol + inositol-1-phospho-N-(2-hydroxy-fatty acyl)-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16615", "l": "an N-acetylarylamine + CoA => acetyl-CoA + an arylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196753", "l": "2xPPCS ligates PPanK with Cys (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51101", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602472", "l": "Defective IRAK4 does not form a complex with MyD88 within the TLR5 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656947", "l": "OGG1beta translocates to mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61287", "l": "H2O + L-cystine + O2 <=> (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39715", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 = (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209828", "l": "Tryptophan is hydroxylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32278", "l": "4-(phosphooxy)-L-threonine + NAD(+) <=> 3-amino-2-oxopropyl phosphate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31605", "l": "(Z)-3-aminoacrylate + carbamate + H(+) => (Z)-3-ureidoacrylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54083", "l": "5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218822", "l": "CRK binds BCAR1 and or PXN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72621", "l": "Ribosomal scanning  (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9028730", "l": "Activated NTRK2 binds FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708866", "l": "pro-F2R binds vorapaxar (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71855", "l": "taurochenodeoxycholate(out) = taurochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55000", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62507", "l": "3-amino-5-hydroxybenzoate + ATP + holo-[aryl-carrier protein] <=> 3-amino-5-hydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935980", "l": "RUNX1 binds the OCLN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68960", "l": "DNA polymerase epsilon binds at the origin (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781941", "l": "WNTs are secreted in exosomes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0015665", "l": "alcohol transmembrane transporter activity", "d": ["Enables the transfer of an alcohol from one side of a membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38269", "l": "3-methylfumaryl-CoA => 2-methylfumaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-912627", "l": "CBL ubiquitinates PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34901", "l": "malonyl-CoA methyl ester + S-adenosyl-L-homocysteine => malonyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68244", "l": "L-phenylalanine(in) + Na(+)(in) = L-phenylalanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26093", "l": "(4R)-limonene + H(+) + NADH + O2 = H2O + limonene 1,2-epoxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070448", "l": "laricitrin 5'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + laricitrin = S-adenosyl-L-homocysteine + syringetin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75923", "l": "(S)-4-aminopentanoate + H2O + NAD(+) = 4-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63358", "l": "(S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2 => (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027598", "l": "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193665", "l": "MYD88 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11842", "l": "benzoate + 2 H(+) + NADH => benzaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75800", "l": "Na(+)(out) + pyruvate(out) => Na(+)(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30196", "l": "15,9'-di-cis-phytofluene + plastoquinone-9 => 9,9',15-tri-cis-zeta-carotene + plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55905", "l": "7-chloro-L-tryptophan + chloride + FADH2 + O2 => 6,7-dichloro-L-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29612", "l": "H2O + NADP(+) + nitrous oxide => H(+) + NADPH + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75544", "l": "(3R)-3-[(carboxylmethyl)amino]decanoate + H(+) + holo-[ACP] => (2E)-decenoyl-[ACP] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129362", "l": "Fibrillin microfibril assembly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140417", "l": "ATP-sensitive calcium-release channel activity", "d": ["Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a ATP has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983147", "l": "Release of E3 from polyubiquitinated substrate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013009", "l": "RHOA binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47761", "l": "a uridine in 21S rRNA + S-adenosyl-L-methionine => a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0033744", "l": "L-methionine:thioredoxin-disulfide S-oxidoreductase activity", "d": ["Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11912", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxoprostaglandin E2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0141047", "l": "molecular tag activity", "d": ["A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another molecule (for example a protein or a lipid) where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392834", "l": "Activation of EPACs by cAMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1671687", "l": "PRLR activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67644", "l": "ATP + dZDP = ADP + dZTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33879", "l": "2-deoxy-scyllo-inosamine + NADP(+) = 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61177", "l": "(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside => CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76031", "l": "2 H2O2 => O2 + 2 H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42704", "l": "hercynine + L-cysteine + O2 = H2O + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": []}, {"i": "EC:1.21.3.10", "l": "\"hercynylcysteine S-oxide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10835", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O <=> 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373745", "l": "SDK1 homophillic interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9681375", "l": "KIT binds ripretinib (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12809", "l": "4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O", "d": []}, {"i": "EC:1.1.3.14", "l": "\"catechol oxidase (dimerizing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58729", "l": "adenosine in rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689630", "l": "BAP1 binds BAP1-interacting complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20027", "l": "gibberellin A3 O-beta-D-glucoside + H(+) + UDP => gibberellin A3 + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336422", "l": "Clathrin-mediated endocytosis of DT:HBEGF:CD9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40990", "l": "EDTA + 2 FMNH2 + 2 O2 <=> ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57207", "l": "glyoxal + L-lysyl-[protein] <=> N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783492", "l": "TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69065", "l": "N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + O2 => H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49759", "l": "H(+) + O2 + protoviolaceinate <=> CO2 + H2O + proviolacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57778", "l": "4-chloro-3-methylcatechol + NAD(+) + nitrite => 2-chloro-6-nitrotoluene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953037", "l": "E2F8 forms homodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24622", "l": "H(+) + NADH + octanal => NAD(+) + octan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67711", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55143", "l": "D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] <=> AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52237", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + Fe(2+) + 3 H2O + mycobilin b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19976", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + S-methyl-5'-thioadenosine + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49039", "l": "(-)-pluviatolide + S-adenosyl-L-methionine <=> (-)-bursehernin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16200", "l": "(3S)-3-hydroxybutanoyl-CoA + NADP(+) <=> acetoacetyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37888", "l": "S-adenosyl-L-methionine + small RNA 3'-end nucleotide => H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19370", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine => H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69028", "l": "5beta-dihydrotestosterone + H(+) + NADPH = 5beta-androstane-3alpha,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26506", "l": "(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11896", "l": "7alpha-hydroxycholesterol + NAD(+) = 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.181", "l": "\"cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174444", "l": "Formation of C-strand Okazaki fragments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70241", "l": "PCK1 phosphorylates OA to yield PEP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205289", "l": "Autophosphorylation of KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158860", "l": "SULT1A1 dimer sulfonates NHABP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18861", "l": "a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine = a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9681375", "l": "KIT binds ripretinib (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31844", "l": "2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA => 2-oxepin-2(3H)-ylideneacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805981", "l": "HMGB1 release from cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3244643", "l": "STING binds cyclic GMP-AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112392", "l": "Resumption of elongation after recovery from pausing (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0018549", "l": "methanethiol oxidase activity", "d": ["Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45163", "l": "3-oxopropanoate + H(+) <=> acetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73797", "l": "FAICAR => IMP + H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696275", "l": "RND2 binds GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42377", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.938386572175233", "identifiers": [{"i": "GO:0042393", "l": "histone binding", "d": ["Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852552", "l": "MST1R autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693250", "l": "RHOD binds effectors at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210444", "l": "L-Glutamate loading of synaptic vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788061", "l": "Fibronectin degradation by ADAM8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43021", "l": "L,L-cystathionine => 2-aminoprop-2-enoate + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48540", "l": "1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O = dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047279", "l": "sn-glycerol-3-phosphate 1-galactosyltransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45829", "l": "(3R)-hydroxyhexanoyl-CoA + NAD(+) => 3-oxohexanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45492", "l": "phycocyanobilin-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941895", "l": "Formation of CDK4/6:CCND complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9679775", "l": "COMT binds COMT Inhibitors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681651", "l": "nsp8 generates RNA primers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16110", "l": "ATP + beta-D-fructose 6-phosphate => ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54197", "l": "N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15595", "l": "amicoumacin A + phosphate => amicoumacin A 2-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55707", "l": "glycine + hydrogen sulfide + NAD(+) <=> ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16456", "l": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O <=> 2-formylbenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042328", "l": "heparan sulfate N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.287", "l": "\"D-arabinitol dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34820", "l": "dihydrocurcumin + NADP(+) => curcumin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46413", "l": "a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55169", "l": "[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) => [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167192", "l": "Pol II elongation complex moves on the HIV-1 template as transcript elongates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75085", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 32-oxo-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839635", "l": "CTNNB1 S37 mutants aren't phosphorylated by GSK3beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45222", "l": "Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[trimethylamine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62236", "l": "a cytidine(6-4)cytidine in DNA = a cytidine dimer in DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21655", "l": "2-chlorobenzoate + H(+) + NADH + O2 <=> catechol + chloride + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30743", "l": "beta-nicotinamide D-riboside + H2O = D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870466", "l": "RGGT:CHM binds RABs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821412", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72203", "l": "2 chloride(out) + hydrogencarbonate(in) = 2 chloride(in) + hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944218", "l": "Association of procollagen type VIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693243", "l": "RHOD translocates to the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47499", "l": "lithocholate + NADP(+) <=> 3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938217", "l": "RUNX1 binds the SWI/SNF complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75139", "l": "4-hydroxyprotoasukamycin + H(+) + NADH + O2 = asukamycin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2106615", "l": "Removal of siRNA passenger strand (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75350", "l": "thiocyanate(in) <=> thiocyanate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672951", "l": "Inactive RAFs bind YWHAB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.-", "l": "\"With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001853", "l": "complement component C3dg binding", "d": ["Binding to a C3dg product of the complement cascade."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944246", "l": "Association of procollagen type XXI (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22157", "l": "GDP + H2O => GMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578965", "l": "TNRC6A binds AGO2:miRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798373", "l": "MDM2 ubiquitinates DYRK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50361", "l": "(R)-mandelonitrile + O2 => benzoyl cyanide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68364", "l": "4-CDP-2-C-methyl-D-erythritol = 2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56264", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400434", "l": "FFAR1 binds fatty acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9717841", "l": "holo-FDPS dimer binds NBPs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621370", "l": "SYK autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954056", "l": "E2F6 binds TFDP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328129", "l": "Dystroglycan binds Laminins and Dystrophin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49967", "l": "5,10-dihydrophenazine + O2 <=> H2O2 + phenazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73480", "l": "D-histidine(in) + H(+)(in) + L-ornithine(out) => D-histidine(out) + H(+)(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26472", "l": "16-feruloyloxyhexadecanoate + CoA => (E)-feruloyl-CoA + 16-hydroxyhexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102378", "l": "steviolmonoside glucosyltransferase activity", "d": ["Catalysis of the reaction: steviolmonoside + UDP-alpha-D-glucose = rubusoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170824", "l": "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34644", "l": "2 S-adenosyl-L-methionine + squalene => 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2470555", "l": "Collagen type X binds Integrin alpha2beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70061", "l": "a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60821", "l": "H2O + NADPH => adenosine 2',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708275", "l": "PDE4A binds PDE4A inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047436", "l": "arylmalonate decarboxylase activity", "d": ["Catalysis of the reaction: 2-aryl-2-methylmalonate + H+ = 2-arylpropionate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53677", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 => 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60965", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose => (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0047979", "l": "hexose oxidase activity", "d": ["Catalysis of the reaction: hexose + O2 = aldono-1,5-lactone + H202."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.2.1.-", "l": "\"Cis-trans isomerases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5627775", "l": "Autophosphorylation of PAK1,2,3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73262", "l": "cirsiliol + S-adenosyl-L-methionine <=> eupatorin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043771", "l": "cytidine kinase activity", "d": ["Catalysis of the reaction: ATP + cytidine = ADP + CMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37104", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O => (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0005165", "l": "neurotrophin receptor binding", "d": ["Binding to a neurotrophin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213017", "l": "Auto-ubiquitination of TRAF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952128", "l": "RUNX3 binds TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624800", "l": "CDK1 phosphorylates LBR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73413", "l": "succinate(out) + sulfate(in) => succinate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71094", "l": "dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) <=> dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36254", "l": "(E)-ferulate + ATP + CoA <=> (E)-feruloyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63599", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51738", "l": "H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35342", "l": "3-hydroxyicosanoyl-CoA + NADP(+) <=> 3-oxoeicosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706344", "l": "FLT3 phosphorylates GRB10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31286", "l": "FAD + H(+) + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28430", "l": "D-allose 6-phosphate = D-allulose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664664", "l": "PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13055", "l": "3-phenylpyruvate + L-alanine => L-phenylalanine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75112", "l": "32-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71079", "l": "cordypyrone A + O2 + reduced [NADPH--hemoprotein reductase] = cordypyrone B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626549", "l": "IQGAPs bind CALM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66470", "l": "(17E)-cheilanthenediol => (2E,6E,10E,14E)-geranylfarnesol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63172", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA = (25R)-3-oxocholest-4-en-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67799", "l": "a ribonucleotidyl-ribonucleotide-RNA <=> a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451152", "l": "MAP kinase p38 phosphorylates KSRP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052659", "l": "inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201443", "l": "Type II receptor phosphorylates type I receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211191", "l": "Association of DFF with alpha:beta importin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730872", "l": "Activation of Calcineurin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679205", "l": "ULK1 phosphorylates Beclin-1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170796", "l": "NPC transports GCK1:GKRP from cytosol to nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54627", "l": "2-oxoglutarate + O2 + octadecanoyl-CoA <=> 2-hydroxyoctadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1470009", "l": "Phosphorylation of STATs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70596", "l": "GOT2 dimer deaminates L-Asp (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72615", "l": "H(+)(out) + L-alanyl-L-valine(out) = H(+)(in) + L-alanyl-L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.419", "l": "\"nepetalactol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21692", "l": "CDP-glycerol + H2O = CMP + 2 H(+) + sn-glycerol 3-phosphate", "d": []}, {"i": "EC:3.6.1.16", "l": "\"CDP-glycerol diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30254", "l": "2 a ubiquinol + n H(+)(in) + O2 <=> 2 a ubiquinone + n H(+)(out) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10821", "l": "D-threo-isocitrate => D-erythro-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41261", "l": "(E)-3-(indol-3-yl)acrylate + NH4(+) => L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53948", "l": "ATP + holo-[BtrI ACP] + L-glutamate = ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106244", "l": "eupatolide synthase activity", "d": ["Catalysis of the reaction: 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352864", "l": "glucose [extracellular] <=> glucose [cytosol] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.26", "l": "\"adenosylcobinamide-GDP ribazoletransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46353", "l": "(2E)-decenoyl-CoA + H2O => 3-hydroxydecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042988", "l": "X11-like protein binding", "d": ["Binding to X11-like protein, a neuron-specific adaptor protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227863", "l": "Recruitment of IRF to activated TBK1/IKK epsilon (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20466", "l": "[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14863", "l": "H(+) + NADPH + orotate => (S)-dihydroorotate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40503", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine = N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647660", "l": "GSDME (1-270) binds PIPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5631885", "l": "PRDX1 overoxidizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59118", "l": "[protein]-disulfide + H2O2 => [protein]-dithiol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067659", "l": "Assembly of hexameric IL-6 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69116", "l": "Formation of Okazaki fragments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034831", "l": "(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-1,2,3,4-tetrahydronaphthol = 1,2,3,4-tetrahydronaphthalone + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392263", "l": "AVP(20-28) binds AVPR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167408", "l": "The high affinity receptor complex binds to G-protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58003", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rg3 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709831", "l": "HSP90 binds TBK1 and IRF3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21325", "l": "2 H(+) + reduced [rubredoxin] + superoxide => H2O2 + oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12720", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032132", "l": "O6-alkylguanine-DNA binding", "d": ["Binding to an O6-alkylguanine adduct in DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59730", "l": "(2S)-ethylmalonyl-CoA => (2R)-ethylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450975", "l": "isocitrate <=> citrate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25984", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (5R)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433418", "l": "Phosphorylation of JAK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047175", "l": "galactosylacylglycerol O-acyltransferase activity", "d": ["Catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0005308", "l": "creatine transmembrane transporter activity", "d": ["Enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032977", "l": "membrane insertase activity", "d": ["Binds transmembrane domain-containing proteins and mediates their integration into a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61672", "l": "ATP + H(+) + L-cysteine = diphosphate + L-cysteinyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30567", "l": "5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate = 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.33", "l": "\"tetrahydrosarcinapterin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005150", "l": "interleukin-1, type I receptor binding", "d": ["Binding to a Type I interleukin-1 receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004315", "l": "3-oxoacyl-[acyl-carrier-protein] synthase activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106591", "l": "WWTR1:SMAD stimulates transcription of SMAD7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68074", "l": "L-thiazolidine-2-carboxylate + NADP(+) => Delta(2)-thiazoline-2-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22545", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O => a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51597", "l": "2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] => 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23358", "l": "ADP + H(+) + O-phospho-L-seryl-[rhodopsin] => ATP + L-seryl-[rhodopsin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52987", "l": "7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] <=> 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43615", "l": "S-adenosyl-L-methionine + uridine(341) in tmRNA <=> 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75769", "l": "10-hydroxyhexadecanoate => (9Z)-hexadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604553", "l": "HEY2 gene expression is stimulated by NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45036", "l": "3 Fe(III)-[cytochrome c] + hydroxylamine = 3 Fe(II)-[cytochrome c] + 3 H(+) + nitric oxide", "d": []}, {"i": "EC:1.7.2.9", "l": "\"hydroxylamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52788", "l": "chlorophyll a + 2 H(+) = Mg(2+) + pheophytin a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48332", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033833", "l": "hydroxymethylfurfural reductase (NADH) activity", "d": ["Catalysis of the reaction: 5-hydroxymethylfurfural + NADH + H+ = 2,5-bis-hydroxymethylfuran + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14598", "l": "a CDP-1,2-diacyl-sn-glycerol + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651773", "l": "LIG1 binds POLB at long-patch BER site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944232", "l": "Association of procollagen type XII (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51091", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36767", "l": "2-hydroxytetracosenoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57017", "l": "3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68653", "l": "2 L-homocysteine => H(+) + hydrogen sulfide + L-homolanthionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5225649", "l": "RBBP7 binds histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60626", "l": "2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869683", "l": "oxPL binds LBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753916", "l": "NAPQI binds proteins in hepatocytes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68567", "l": "6-methoxycoumarin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15517", "l": "H2O + N(2),6-disulfo-D-glucosamine = H(+) + N-sulfo-D-glucosamine + sulfate", "d": []}, {"i": "EC:3.1.6.11", "l": "\"disulfoglucosamine-6-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12270", "l": "1-pyrroline + H2O + L-glutamate => 2-oxoglutarate + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20250", "l": "L-alanine => D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33989", "l": "diphosphate + neoabietadiene => (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33616", "l": "ATP + CoA + octadecanoate => AMP + diphosphate + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.150", "l": "\"oligoxyloglucan reducing-end-specific cellobiohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69187", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-glycerol 1-phosphate <=> diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1008200", "l": "NFE2 binds the beta globin locus control region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25706", "l": "H(+) + N,N-dihydroxy-L-dihomomethionine = (E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174070", "l": "Association of Cdh1 with the APC/C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033948", "l": "fructan beta-(2,1)-fructosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing (2->1) linked beta-D-fructofuranose residues in fructans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549304", "l": "OCT3 mediates renal clearance of organic cations (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14188", "l": "3-phenylpyruvate + H(+) <=> 2-phenylacetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790944", "l": "NOP2 (NSUN1) methylates cytidine-4447 of 28S rRNA yielding 5-methylcytidine-4447 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65293", "l": "2 ATP + butan-2-one + 3 H2O + hydrogencarbonate => 3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174202", "l": "Degradation of multiubiquitinated Securin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62154", "l": "dGDP + dTDP => dGMP + dTTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20857", "l": "an N-acylsphing-4-enine + H2O => a fatty acid + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610741", "l": "PKA phosphorylates GLI1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61174", "l": "H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP => myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033848", "l": "N2-(2-carboxyethyl)arginine synthase activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L-arginine + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168886", "l": "Hemopexin binds Hemes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57982", "l": "(20S)-ginsenoside F1 + H(+) + UDP => (20S)-protopanaxatriol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74954", "l": "(3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + 2-oxoglutarate + O2 <=> (3R)-3-isocyanylbutanoate + 2 CO2 + 2 H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.16", "l": "\"spermine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032800", "l": "Expression of NPPA (ANF) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981355", "l": "RASA1 binds RAS:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21020", "l": "5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate", "d": []}, {"i": "EC:4.2.3.5", "l": "\"chorismate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354097", "l": "Activation of Talin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692408", "l": "NPR2 binds NPPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043831", "l": "thiosulfate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: 6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684275", "l": "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46821", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382096", "l": "Formation of NR-NCOR Corepressor Complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71938", "l": "glycocholate(out) + 2 Na(+)(out) <=> glycocholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021609", "l": "ESR-associated SRC autophosphorylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70648", "l": "D-serine(out) + H(+)(out) => D-serine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61935", "l": "(S)-miconazole(in) + ATP + H2O <=> (S)-miconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30195", "l": "15,9'-di-cis-phytofluene + plastoquinone-9 = 9,9',15-tri-cis-zeta-carotene + plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797100", "l": "CCNK binds CDK13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130731", "l": "Formation of COPII vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53457", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983707", "l": "SYK autophosphorylates at the activated BCR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75582", "l": "A + cyathatriol <=> AH2 + cyathin A3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805792", "l": "p-S291-PHF20 translocates to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1013833", "l": "Cables link CDK5 and ABL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57707", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) <=> 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40926", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47243", "l": "H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75795", "l": "Na(+)(out) + nicotinate(out) = Na(+)(in) + nicotinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63329", "l": "2-(9Z-octadecenoyl)-glycerol + ATP => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28564", "l": "pyridoxamine 5'-phosphate + pyruvate => D-alanine + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201515", "l": "Active ALK recruits PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51770", "l": "4-prenylphlormethylbutanophenone + diphosphate => 2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60118", "l": "CO2 + hydroxymethylphosphonate + succinate => 2-oxoglutarate + methylphosphonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49944", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate = (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68511", "l": "(2E,6E)-farnesyl diphosphate <=> (Z)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.29", "l": "\"[heparan sulfate]-glucosamine 3-sulfotransferase 2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004339", "l": "glucan 1,4-alpha-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682020", "l": "MRN complex binds shortened telomeres (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875523", "l": "MET binds TNS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39103", "l": "ATP + H2O + sitosterol(in) = ADP + H(+) + phosphate + sitosterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23536", "l": "alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62436", "l": "L-lyxonate = 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": []}, {"i": "EC:4.2.1.176", "l": "\"L-lyxonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114256", "l": "CYCS:APAF1 binds procaspase-9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17925", "l": "alpha-L-arabinopyanose + NAD(+) = H(+) + L-arabinono-1,4-lactone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67814", "l": "a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625426", "l": "Retrograde IFT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28984", "l": "nitrite(in) => nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66805", "l": "ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53871", "l": "2 H(+) + NADH + O2 + phenazine-1-carboxylate <=> 1-hydroxyphenazine + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42928", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.199", "l": "\"16S rRNA (cytosine(1402)-N(4))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3318415", "l": "ATF2 acetylates histone H2B, H4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34430", "l": "(-)-lariciresinol + NADP(+) <=> (-)-pinoresinol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30156", "l": "FADH2 + 2 Fe(3+) => FAD + 2 Fe(2+) + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69177", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] => 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419003", "l": "Interaction of Nectins with Afadin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912291", "l": "Incorrectly folded glycoproteins translocate to the ERQC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34040", "l": "2-oxoglutarate + neamine => 6'-oxoparomamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452331", "l": "Expression of TBXT (T, Brachyury) in the primitive streak (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28473", "l": "pyridoxine(in) <=> pyridoxine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69053", "l": "RFC binding displaces Pol Alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21736", "l": "(3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73507", "l": "7,8-dihydroxyflavone + S-adenosyl-L-methionine = 7-hydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004649", "l": "poly(ADP-ribose) glycohydrolase activity", "d": ["Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36604", "l": "2-oxoglutarate + L-enduracididine + O2 => (3S)-3-hydroxy-L-enduracididine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109700", "l": "AKT2 binds PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679775", "l": "COMT binds COMT Inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53775", "l": "chenodeoxycholate + lithocholoyl-CoA <=> chenodeoxycholoyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54872", "l": "(1S,4R)-menthone + H(+) + NADPH + O2 = (4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470009", "l": "Phosphorylation of STATs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944250", "l": "Association of procollagen type XXV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032408", "l": "MutSbeta complex binding", "d": ["Binding to a MutSbeta mismatch repair complex."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140759", "l": "histone H3K56 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 56) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 56). This reaction is the addition of a methyl group to the lysine residue at position 56 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047712", "l": "Cypridina-luciferin 2-monooxygenase activity", "d": ["Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170824", "l": "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617217", "l": "Phospho-CREB1 binds the promoter of the CEBPB gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987043", "l": "IL22RA1 binds JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31224", "l": "cis-beta-D-glucosyl-2-hydroxycinnamate + H2O => beta-D-glucose + cis-2-coumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021520", "l": "NOTCH3 binds WWP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61613", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 => 7-epi-cylindrospermopsin + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671772", "l": "p-T38-PPP1R14A binds MLCP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627870", "l": "SLC26A4 does not transport I- from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12324", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine = L-asparagine + N-acetyl-D-glucosamine", "d": []}, {"i": "EC:3.2.2.11", "l": "\"beta-aspartyl-N-acetylglucosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34156", "l": "acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine => CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73194", "l": "(2R,3S,11R)-aszonalenin + acetyl-CoA <=> (2R,3S,11R)-acetylaszonalenin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69095", "l": "H2O + NAD(+) + pentanal <=> 2 H(+) + NADH + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52234", "l": "3 A + Fe(2+) + 3 H2O + mycobilin a => 3 AH2 + 2 H(+) + heme b + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51821", "l": "ATP(in) + CoA(in) + decanoate(out) + H(+)(out) => AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50096", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951500", "l": "Dissociation of CANX from nonameric complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-179421", "l": "Degradation of multiubiquitinated Nek2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61029", "l": "itaconate + L-cysteinyl-[protein] => S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034070", "l": "aminoglycoside 1-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 1-N-acetylaminoglycoside. This is acetylation of the 1-amino group of the central deoxystreptamine ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654125", "l": "Defective SLC39A4 does not transport Zn2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69490", "l": "H2O2 + tetradecanal => O2 + tetradecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63204", "l": "H2O + octadecanoyl-[ACP] = H(+) + holo-[ACP] + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.166", "l": "\"heparanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028730", "l": "Activated NTRK2 binds FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374686", "l": "L1 interaction with Integrins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66381", "l": "ATP + glutathione(in) + glycodeoxycholate(in) + H2O => ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31368", "l": "2 H(+) + 3 nitrite => H2O + nitrate + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36644", "l": "emodin + S-adenosyl-L-methionine => H(+) + questin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008951", "l": "palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity", "d": ["Catalysis of the reaction: a palmitoleoyl-[acyl-carrier protein] + alpha-KDO-(2->4)-alpha-KDO-(2->6)-lipid IVA = KDO2-(palmitoleoyl)-lipid IVA + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24381", "l": "(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12779", "l": "2-amino-4,7-dihydroxypteridine + chemical entity => 2-amino-4-hydroxypteridine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391939", "l": "TP receptor can bind thromboxane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187575", "l": "Ubiquitination of phospho-p27/p21 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68978", "l": "7-oxoglycolithocholate + H(+) + NADPH => glycoursodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981093", "l": "IL12 bound to IL12R internalises (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65725", "l": "2-oxoglutarate + O2 + pentyl sulfate => CO2 + H(+) + pentanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004303", "l": "estradiol 17-beta-dehydrogenase [NAD(P)] activity", "d": ["Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40675", "l": "L-threonine = 2-aminobut-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68110", "l": "H(+) + keto-L-fructose + NADH => L-glucitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69080", "l": "3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+) = 3,4-dihydroxyphenylacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11141", "l": "alpha-D-mannose 1-phosphate => D-mannose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693783", "l": "NAALADases hydrolyse NAAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65335", "l": "H(+) + NADPH + O2 + verruculide A <=> chrodrimanin E + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682377", "l": "LC3 de-lipidation by ATG4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46640", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH = 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201622", "l": "Caspase-mediated cleavage of gelsolin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30763", "l": "H2O + L-valine + NAD(+) = 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.23", "l": "\"valine dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855111", "l": "VLDLR binds PCSK9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41172", "l": "1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O => 2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034038", "l": "deoxyhypusine synthase activity", "d": ["Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195304", "l": "Association of beta-catenin with the destruction complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12095", "l": "(S)-acetoin <=> (R)-acetoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008494", "l": "translation activator activity", "d": ["Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424476", "l": "Activation of RAC1 by VAV2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60919", "l": "a cytidine in mRNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140814", "l": "glycine betaine:sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + Na+(out) + Cl-(out)= glycine betaine(in) + Na+(in) + Cl-(in)."]}, {"i": "RHEA:71175", "l": "2 chloride(out) + glycine betaine(out) + 3 Na(+)(out) = 2 chloride(in) + glycine betaine(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912790", "l": "CBL binds CRK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59348", "l": "D-maltobiono-1,5-lactone + H2O = D-maltobionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10244", "l": "4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)", "d": []}, {"i": "EC:3.7.1.2", "l": "\"fumarylacetoacetase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43246", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983152", "l": "Transfer of ubiquitin from E1 to E2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24687", "l": "H2O + N-formylmethanofuran => formate + methanofuran", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57963", "l": "dimethyl sulfide + H(+) + NADH + O2 <=> dimethyl sulfoxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72155", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102062", "l": "alpha-santalene synthase activity", "d": ["Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20002", "l": "glycolaldehyde + H2O + NAD(+) => glycolate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60745", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone => CoA + pyrethrin I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788684", "l": "TRMT13 2'-O-methylates cytidine-4 in tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47611", "l": "3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57866", "l": "4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41928", "l": "(2E)-octadecenoyl-[ACP] + H(+) + NADPH = NADP(+) + octadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805640", "l": "AKT phosphorylates KAT6A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19840", "l": "D-sorbitol 6-phosphate + NAD(+) <=> beta-D-fructose 6-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52990", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine => [deoxyhypusine synthase]-L-lysine + dehydrospermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717202", "l": "GNAT3 exchanges GDP for GTP in L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140696", "l": "(S)-2-hydroxyglutarate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53600", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823816", "l": "OPTN binds CASP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33384", "l": "(S)-malate + UDP-N-acetyl-alpha-D-glucosamine => (S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30744", "l": "beta-nicotinamide D-riboside + H2O => D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18348", "l": "a cis-3-alkyl-4-alkyloxetan-2-one <=> a cis-alkene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21231", "l": "alpha-maltose <=> beta-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26090", "l": "(4S)-limonene + H(+) + NADH + O2 => H2O + limonene 1,2-epoxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237160", "l": "MTA is cleaved and phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3318415", "l": "ATF2 acetylates histone H2B, H4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203901", "l": "Pol II mediated transcription of microRNA genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62445", "l": "L-canavanine + L-ornithine => H(+) + L-arginine + L-canaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004903", "l": "growth hormone receptor activity", "d": ["Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210805", "l": "Removal of miRNA passenger strand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66664", "l": "ATP + coproporphyrin III(in) + H2O = ADP + coproporphyrin III(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20065", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62504", "l": "3-amino-5-hydroxybenzoate + ATP + holo-[aryl-carrier protein] = 3-amino-5-hydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.74", "l": "\"3-amino-5-hydroxybenzoate--[acyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086083", "l": "SUMOylation of ING2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52948", "l": "deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65799", "l": "fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41651", "l": "aniline + ATP + L-glutamate <=> ADP + N(5)-phenyl-L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400434", "l": "FFAR1 binds fatty acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044824", "l": "retroviral 3' processing activity", "d": ["The catalysis of the removal of two di- or tri-nucleotides from each 3' end of double-stranded viral DNA, exposing recessed 3' hydroxyls."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.161", "l": "\"beta-apiosyl-beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34403", "l": "9-cis-10'-apo-beta-carotenal + 2 O2 = (11R)-carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal", "d": []}, {"i": "EC:1.13.11.69", "l": "\"carlactone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73583", "l": "CTP(out) + UDP(in) = CTP(in) + UDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1017228", "l": "Glycoproteins with lesser folding defects get transported back to the ER and the CNX/CRT complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036042", "l": "long-chain fatty acyl-CoA binding", "d": ["Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662986", "l": "MT2A binds copper (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9728664", "l": "GLP1R binds GLP1R agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23931", "l": "H2O + N(8)-acetylspermidine <=> acetate + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727292", "l": "mRNA6 is translated to protein 6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32673", "l": "ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate => ATP + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46287", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72004", "l": "(S)-lactate(in) + urate(out) => (S)-lactate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683801", "l": "CHEK2 phosphorylates BRCA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132187", "l": "MBL or ficolin binds an oligosaccharide pattern on the target cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25645", "l": "(2R,5R)-isomenthone + NADP(+) = (R)-pulegone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.133", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888577", "l": "Synthesis of GABA by GAD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62979", "l": "(9Z,12Z,15Z)-octadecatrienamide + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72394", "l": "2 hydrogencarbonate(out) + oxalate(in) <=> 2 hydrogencarbonate(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23897", "l": "5-dehydro-4-deoxy-D-glucuronate => 3-deoxy-D-glycero-2,5-hexodiulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174171", "l": "Association of Cyclin A with the APC/C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2167917", "l": "SMAD7 binds to SMURF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70164", "l": "H(+)(in) + methotrexate(in) => H(+)(out) + methotrexate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653957", "l": "Rag dimer formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37935", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44526", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66502", "l": "alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855047", "l": "Hydrolysis of internal thioester in C4b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209903", "l": "Noradrenaline is converted to adrenaline (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37041", "l": "5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O => 5 AH2 + 2 H(+) + heme b + 4 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55007", "l": "1-hydroxylimonen-2-one + NADPH + O2 <=> 3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54484", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine = 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392749", "l": "Transport of L1 into endosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166072", "l": "MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9609310", "l": "β-blockers bind ADRB1,2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2169046", "l": "Degradation of TGF-beta receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561072", "l": "OCT3 mediates renal uptake of organic cations (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.-.-", "l": "\"Acting on the aldehyde or oxo group of donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202394", "l": "Translocation of CARMA1 to Plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047816", "l": "D-arabinose 1-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: D-arabinose + NAD+ = D-arabinono-1,4-lactone + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190698", "l": "Transport of connexins to the ER-Golgi intermediate compartment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158313", "l": "factor XII -> factor XIIa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.69", "l": "\"type 1 galactoside alpha-(1,2)-fucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24215", "l": "5-(2-hydroxyethyl)-4-methylthiazole + ATP <=> 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54721", "l": "N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174444", "l": "Formation of C-strand Okazaki fragments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686088", "l": "CASP3 cleaves GSDMD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928657", "l": "MMP2,9 cleave EPHB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6805061", "l": "CK2 binds FACT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174445", "l": "RPA binds to the Flap on the C-strand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697070", "l": "lprG dissociates from LAM,LM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-421831", "l": "trans-Golgi Network Coat Assembly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809764", "l": "SBF1 binds MTMR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30337", "l": "NH4(+) + UTP => CTP + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26069", "l": "3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O => CoA + H(+) + phosphinomethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660660", "l": "p300 acetylates RELA subunit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67409", "l": "gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + thymol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68854", "l": "(1S,6S,7R)-sesquipiperitol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679239", "l": "ULK complex translocates to the ER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42614", "l": "a plastoquinol + n H(+)(out) + NADP(+) => a plastoquinone + (n+1) H(+)(in) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27708", "l": "ADP + D-alanyl-D-serine + H(+) + phosphate => ATP + D-alanine + D-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47741", "l": "1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate => CO2 + demethylphylloquinone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17969", "l": "ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine", "d": []}, {"i": "EC:6.3.2.7", "l": "\"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043766", "l": "Sep-tRNA:Cys-tRNA synthase activity", "d": ["Catalysis of the reaction: H+ + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) = L-cysteinyl-tRNA(Cys) + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029680", "l": "Caspase-7 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54824", "l": "H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] = alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": []}, {"i": "EC:3.2.1.130", "l": "\"glycoprotein endo-alpha-1,2-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14085", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA = 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375149", "l": "Interaction of NCAM1 with GFRalpha-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36900", "l": "guanosine(37) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13738", "l": "an n-alkanal + NADP(+) => an alk-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-382096", "l": "Formation of NR-NCOR Corepressor Complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112429", "l": "Formation of FACT complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28717", "l": "(R)-malate(out) + 2 H(+)(out) => (R)-malate(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45161", "l": "3-oxopropanoate + H(+) => acetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24216", "l": "(2E,6E)-farnesal + H2O + NAD(+) = (2E,6E)-farnesoate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.94", "l": "\"farnesal dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295622", "l": "SPRY2 binds CBL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42498", "l": "10-deacetyl-2-debenzoylbaccatin III => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75331", "l": "chloride(out) + D-methionine(out) + 2 Na(+)(out) = chloride(in) + D-methionine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709317", "l": "CO binds to free ferrohemoglobin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687097", "l": "p-S857 NCOA3 binds ETV4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66833", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + preasperterpenoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35653", "l": "an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+) => (4R)-hydroxysphinganine + a fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40961", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173709", "l": "C7 binds C5b:C6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483219", "l": "PC is exchanged with PI by PITPNB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852331", "l": "GTSE1 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41350", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2247510", "l": "MARCO:ligand is endocytosed (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12234", "l": "[thioredoxin]-dithiol + glycine + H(+) + phosphate => [thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113446", "l": "Initiation of RNA Polymerase III Productive Transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134914", "l": "Beta-catenin migrates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372542", "l": "Loading of dopamine into synaptic veiscles (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75620", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate => ectocarpin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-561072", "l": "OCT3 mediates renal uptake of organic cations (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009000", "l": "selenocysteine lyase activity", "d": ["Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855111", "l": "VLDLR binds PCSK9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21643", "l": "NADP(+) + prephenate <=> 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36323", "l": "(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH = (9Z)-octadecen-1-ol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71726", "l": "H(+)(out) + L-alanyl-L-leucyl-L-alanine(out) <=> H(+)(in) + L-alanyl-L-leucyl-L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32551", "l": "(2E)-geranyl diphosphate + H2O = (S)-alpha-terpineol + diphosphate", "d": []}, {"i": "EC:4.2.3.111", "l": "\"(-)-alpha-terpineol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17589", "l": "2,2'-iminodipropanoate + H2O + NAD(+) = H(+) + L-alanine + NADH + pyruvate", "d": []}, {"i": "EC:1.5.1.17", "l": "\"alanopine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63654", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57430", "l": "formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol => anisole + O2 + reduced [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.1", "l": "\"deoxyribonuclease II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0070888", "l": "E-box binding", "d": ["Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46075", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADH <=> hexadecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807565", "l": "GNLY is transferred to the phagosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67645", "l": "ATP + dZDP => ADP + dZTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9645598", "l": "RRAGC,D hydrolyzes GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114352", "l": "Sequestration of tBID by BCL-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004424", "l": "imidazoleglycerol-phosphate dehydratase activity", "d": ["Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70596", "l": "GOT2 dimer deaminates L-Asp (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855375", "l": "PTPN22 dissociates from CSK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34733", "l": "CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine => 15-methylhexadecasphing-4-enine + a fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22409", "l": "dimethylallyl diphosphate + isopentenyl diphosphate => (2E)-geranyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50408", "l": "1-(2-aminophenyl)decane-1,3-dione = 2-heptyl-4(1H)-quinolone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203712", "l": "eNOS associates with Caveolin-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64971", "l": "dUTP + H2O <=> dUDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444476", "l": "FPRL2 receptor binds a wide range of ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26132", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530591", "l": "CREG (CR1L) causes dissociation of C3 convertases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-532549", "l": "MPI isomerises Fru6P to Man6P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56792", "l": "2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39370", "l": "(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH <=> (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53132", "l": "A + a 3-oxo-Delta(4)-steroid = a 3-oxo-Delta(1,4)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37783", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936628", "l": "GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23078", "l": "2,4-dichlorobenzoyl-CoA + NADPH => 4-chlorobenzoyl-CoA + chloride + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004911", "l": "interleukin-2 receptor activity", "d": ["Combining with interleukin-2 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61108", "l": "(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-438019", "l": "activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110307", "l": "REV1 binds AP-dsDNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15231", "l": "diphosphate + GDP-alpha-D-mannose => alpha-D-mannose 1-phosphate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54098", "l": "H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5226979", "l": "ADD1:ADD2 binds DMTN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202692", "l": "PIP3 binds to RhoA and activates it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33667", "l": "H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2 = H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12118", "l": "AH2 => A + H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102215", "l": "thiocyanate methyltransferase activity", "d": ["Catalysis of the reaction: thiocyanate + S-adenosyl-L-methionine <=> methyl thiocyanate + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067667", "l": "IL6 binds IL6R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58738", "l": "5-methyl-UMP + diphosphate + H(+) => H2O + TTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39099", "l": "3-oxodecanedioyl-CoA + CoA = acetyl-CoA + octanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850945", "l": "Casein kinase II phosphorylates PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050152", "l": "omega-amidase activity", "d": ["Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37521", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56244", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74284", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IIA => a 2-acyl-sn-glycero-3-phosphocholine + a lipid IIB", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13005", "l": "(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine = H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.115", "l": "\"(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691363", "l": "nsp12 binds nsp7 and nsp8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684008", "l": "NBN binds KPNA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033735", "l": "aspartate dehydrogenase activity", "d": ["Catalysis of the reaction: L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72414", "l": "inulobiose <=> alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45284", "l": "eicosanoyl-CoA + sphing-4-enine = CoA + H(+) + N-eicosanoyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14695", "l": "a dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP => a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672957", "l": "PP2A dephosphorylates KSR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40743", "l": "(20S)-ginsenoside Rd + 2 H2O = (20S)-ginsenoside C-K + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58617", "l": "N-octanoyl-(2S)-hydroxyglycine => glyoxylate + octanamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102978", "l": "furaneol oxidoreductase activity", "d": ["Catalysis of the reaction: 4-hydroxy-2,5-dimethylfuran-3-one + NADP <=> 4-hydroxy-5-methyl-2-methylenefuran-3-one + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935988", "l": "OCLN (Occludin) gene expression is stimulated by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-398184", "l": "LARG activation by G alpha 12/13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236968", "l": "Egress of internalized antigen into cytosol from early endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37707", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38818", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35701", "l": "(2S-3S)-versiconal hemiacetal + H(+) + NADPH => (S)-versiconol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174124", "l": "Dephosphorylation of phospho-Cdh1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034951", "l": "o-hydroxylaminobenzoate mutase activity", "d": ["Catalysis of the reaction: o-hydroxylaminobenzoate = 3-hydroxyanthranilate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392195", "l": "Gi activation by P2Y purinoceptor 12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102388", "l": "UDP-N,N'-diacetylbacillosamine 2-epimerase activity", "d": ["Catalysis of the reaction: UDP-N,N'-diacetylbacillosamine + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60890", "l": "(N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11605", "l": "[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873794", "l": "PCTP binds PC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33079", "l": "6-amino-6-deoxyfutalosine + H2O = adenine + dehypoxanthine futalosine", "d": []}, {"i": "EC:3.2.2.30", "l": "\"aminodeoxyfutalosine nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59601", "l": "5-methoxytryptamine + H2O + O2 => 5-methoxyindoleacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11559", "l": "(S)-carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395784", "l": "Nascent CMs transform into mature CMs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54081", "l": "5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine => 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62129", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dGTP => a 2'-deoxyribonucleoside 5'-diphosphate + dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66824", "l": "2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50588", "l": "13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451033", "l": "(S)-Malate <=> Fumarate + H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57984", "l": "(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose = (20S)-ginsenoside Rd + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10192", "l": "ATP + H2O + sulfate(out) = ADP + H(+) + phosphate + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66369", "l": "6-methyl-3,7-dioxodecanedioyl-CoA + CoA => 4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44492", "l": "3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374673", "l": "L1 binds RanBPM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296233", "l": "T2Rs bind bitter-tasting compounds (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27659", "l": "2-deoxy-alpha-D-ribose 1-phosphate => 2-deoxy-D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665311", "l": "ERBB2 T798M does not bind afatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23156", "l": "(E)-(indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H2O", "d": []}, {"i": "EC:4.8.1.3", "l": "\"indoleacetaldoxime dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57103", "l": "S-methyl-5-thio-D-ribulose 1-phosphate <=> S-methyl-1-thio-D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201457", "l": "BMP2 binds to the receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73598", "l": "CTP(out) + dUMP(in) <=> CTP(in) + dUMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2134519", "l": "TGFBR2 is recruited to tight junctions after TGF-beta stimulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31230", "l": "di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine <=> di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54437", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 => a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69862", "l": "a uridine in 12S rRNA + S-adenosyl-L-methionine <=> a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65422", "l": "GMP(out) + NAD(+)(in) => GMP(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39241", "l": "NADP(+) + triacontanoyl-CoA => (2E)-triacontenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23287", "l": "isopentenyl diphosphate <=> dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11892", "l": "6-O-methylnorlaudanosoline + S-adenosyl-L-methionine = H(+) + nororientaline + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.121", "l": "\"6-O-methylnorlaudanosoline 5'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.67", "l": "\"choriolysin H\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140439", "l": "protein-cysteine S-stearoyltransferase activity", "d": ["Catalysis of the transfer of a stearoyl (systematic name, octadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: octadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-octadecanoyl-L-cysteinyl-[protein]."]}, {"i": "RHEA:59740", "l": "L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + S-octadecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22112", "l": "isoxazolin-5-one + O-acetyl-L-serine = 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)", "d": []}, {"i": "EC:2.5.1.118", "l": "\"beta-(isoxazolin-5-on-2-yl)-L-alanine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50950", "l": "a 2'-deoxyuridine in single-stranded DNA + NH4(+) => a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53707", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O <=> H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61780", "l": "keto-L-tagatose = keto-L-sorbose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41143", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940134", "l": "FOLR2 binds FOLA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45666", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51864", "l": "(2E)-geranyl diphosphate + esculetin = 8-geranylesculetin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047847", "l": "deoxyuridine phosphorylase activity", "d": ["Catalysis of the reaction: deoxyuridine + phosphate = uracil + deoxy-D-ribose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74733", "l": "Insulin receptor de-phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43717", "l": "[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate => [glutamine synthetase]-L-tyrosine + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0046982", "l": "protein heterodimerization activity", "d": ["Binding to a nonidentical protein to form a heterodimer."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50051", "l": "ATP + cholate(in) + H2O <=> ADP + cholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37878", "l": "aklanonate + S-adenosyl-L-methionine <=> methyl aklanonate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351948", "l": "Mitochondrial recruitment of Drp1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41947", "l": "[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP <=> [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16882", "l": "hydrogen cyanide + thiosulfate => 2 H(+) + sulfite + thiocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.10", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047796", "l": "cyclohexane-1,3-dione hydrolase activity", "d": ["Catalysis of the reaction: cyclohexane-1,3-dione + H2O = 5-oxohexanoate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61659", "l": "(2E,6E)-farnesol + ATP <=> (2E,6E)-farnesyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050349", "l": "triacetate-lactonase activity", "d": ["Catalysis of the reaction: H2O + triacetate lactone = triacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5658435", "l": "RAS GAPs bind RAS:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49581", "l": "(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate => cyclic pyranopterin phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15396", "l": "(2S,6S)-2,6-diaminoheptanedioate <=> meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140567", "l": "membrane protein dislocase activity", "d": ["The activity of removing a protein from a membrane, by binding to a transmembrane helical fragment of a tail-anchored protein and releasing it from the the hydrophobic region of one or both lipid bilayers. The reaction is driven by ATP hydrolysis."]}, {"i": "RHEA:66168", "l": "[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983156", "l": "Polyubiquitination of substrate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750942", "l": "USP14 deubiquitinates NLRC5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74829", "l": "UDP-alpha-D-galacturonate(out) + UMP(in) => UDP-alpha-D-galacturonate(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47951", "l": "H2O + thiamine phosphate <=> phosphate + thiamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684261", "l": "MAP3K8 is phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47900", "l": "ganglioside GM3 (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57865", "l": "indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14558", "l": "H2O + raucaffricine => D-glucose + vomilenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36387", "l": "carbamoyl adenylate + kanamycin A = 6''-O-carbamoylkanamycin A + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.100", "l": "\"2,1-fructan:2,1-fructan 1-fructosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112429", "l": "Formation of FACT complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44508", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12299", "l": "deacetylipecoside + H2O <=> dopamine + secologanin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625520", "l": "MSTN gene expression is stimulated by FOXO1 and p-2S-SMAD2/3:SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982792", "l": "Growth hormone receptor binds JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448702", "l": "Caspase-1 active tetramer formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202604", "l": "Formation of a heteromeric BMP receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70221", "l": "20beta-dihydrocorticosterone + NADP(+) => corticosterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10327", "l": "an L-glycol + NADP(+) <=> a 2-hydroxycarbonyl + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42649", "l": "(2,5-ethylene furandicarboxylate)(n) + 2 H2O => (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53119", "l": "an 11beta-hydroxysteroid + NAD(+) <=> an 11-oxosteroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903777", "l": "melibiose binding", "d": ["Binding to melibiose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75077", "l": "dihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine => dihydro-6-demethylsterigmatocystin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28854", "l": "melibiose(in) + Na(+)(in) <=> melibiose(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388817", "l": "ICOS binds ICOSL/B7-H2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11913", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) => 15-oxoprostaglandin E2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0023024", "l": "MHC class I protein complex binding", "d": ["Binding to a class I major histocompatibility complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449117", "l": "TXLNA (IL14) binds syntaxin1A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52131", "l": "a 5'-end adenosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O <=> a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55941", "l": "all-trans-3,4-didehydroretinol + NAD(+) => all-trans-3,4-didehydroretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37498", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31832", "l": "(2E,6E)-farnesyl diphosphate => delta-guaiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389919", "l": "Grb2 binds pBTLA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19889", "l": "alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose", "d": []}, {"i": "EC:2.7.7.9", "l": "\"UTP--glucose-1-phosphate uridylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791387", "l": "TP53 binds the ARID3A gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35986", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390912", "l": "HRH1 binds hist (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69879", "l": "6alpha-hydroxycastasterone + O2 + reduced [NADPH--hemoprotein reductase] = castasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9793444", "l": "ITCH polyubiquitinates MLKL at K50 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636404", "l": "LAM translocates from the cell wall to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63335", "l": "alpha-L-arabinopyanose <=> beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31529", "l": "(S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O => N(omega)-hydroxy-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5685953", "l": "SIRT6 deacetylates RBBP8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749253", "l": "Formation of MCM2-7 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046405", "l": "glycerol dehydratase activity", "d": ["Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40506", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine <=> N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162657", "l": "Inactivation of Myt1 kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55844", "l": "calcidiol + UDP-alpha-D-glucuronate = calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103006", "l": "9,10-dihydroxystearate hydroxylase activity", "d": ["Catalysis of the reaction: H+ + (9R,10S)-dihydroxystearate + O2 + NADPH <=> 9,10,18-trihydroxystearate + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53685", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 => 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662597", "l": "MT1H binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389352", "l": "Translocation of Vav1 to CD28 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237129", "l": "Acireductone is created (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008795", "l": "NAD+ synthase activity", "d": ["Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19928", "l": "D-ribitol 5-phosphate + NAD(+) <=> D-ribulose 5-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102969", "l": "10-oxogeraniol oxidoreductase activity", "d": ["Catalysis of the reaction: (6E)-8-oxogeraniol + NADP <=> (6E)-8-oxogeranial + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688786", "l": "ATXN3 binds RAD23 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28901", "l": "glycine(out) + H(+)(out) => glycine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004067", "l": "asparaginase activity", "d": ["Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030942", "l": "endoplasmic reticulum signal peptide binding", "d": ["Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036435", "l": "K48-linked polyubiquitin modification-dependent protein binding", "d": ["Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein."]}, {"i": "REACT:R-HSA-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20556", "l": "(R)-methylmalonyl-CoA <=> (S)-methylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20526", "l": "ATP + ethylamine + L-glutamate => ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61662", "l": "(2E)-geranyl phosphate + ADP + H(+) => (2E)-geraniol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5658435", "l": "RAS GAPs bind RAS:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51812", "l": "ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50740", "l": "H2O + leukotriene C4 = glycine + leukotriene F4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21686", "l": "beta-alanine + H(+) + NADH + pyruvate => (R)-beta-alanopine + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28366", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate = beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.180", "l": "\"lipopolysaccharide N-acetylmannosaminouronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70692", "l": "ornithine => putrescine + CO2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52551", "l": "L-threonate + NAD(+) <=> 2-dehydro-L-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001608", "l": "G protein-coupled nucleotide receptor activity", "d": ["Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39326", "l": "(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22949", "l": "D-tagatofuranose 1,6-bisphosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36377", "l": "carbamoyl adenylate + diphosphate + phosphate => ATP + carbamoyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35095", "l": "choline = acetaldehyde + trimethylamine", "d": []}, {"i": "EC:4.3.99.4", "l": "\"choline trimethylamine-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051525", "l": "NFAT protein binding", "d": ["Binding to NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12703", "l": "[thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate => [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36183", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11485", "l": "a quinol + 2 Fe(III)-[cytochrome c](out) => a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54877", "l": "(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one => (3S)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11668", "l": "[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O = [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": []}, {"i": "EC:2.7.9.4", "l": "\"alpha-glucan, water dikinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61756", "l": "stevioside + UDP-alpha-D-glucose = H(+) + rebaudioside A + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5615668", "l": "AKR1C3 reduces atRAL to atROL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10602", "l": "prostaglandin D2 => prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21459", "l": "(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24811", "l": "3-methyl-2-oxobutanoate + H2O => (2R)-2,3-dihydroxy-3-methylbutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24735", "l": "2-oxoglutarate + 4-hydroxybutanoate => (R)-2-hydroxyglutarate + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788622", "l": "p-Y-STATs dimerize (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60376", "l": "D-glucose(out) = D-glucose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944215", "l": "Association of procollagen type XX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39139", "l": "(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O = (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47412", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54906", "l": "(9Z)-hexadecenoyl-[ACP] + NAD(+) => (2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30119", "l": "dodecanoyl-[ACP] + H2O = dodecanoate + H(+) + holo-[ACP]", "d": []}, {"i": "EC:3.1.2.21", "l": "\"dodecanoyl-[acyl-carrier-protein] hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18317", "l": "an L-alpha-amino acid = a D-alpha-amino acid", "d": []}, {"i": "EC:5.1.1.10", "l": "\"amino-acid racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39982", "l": "(+-)-pavine + S-adenosyl-L-methionine <=> H(+) + N-methylpavine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59928", "l": "erythritol + NADP(+) = D-erythrose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65282", "l": "3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Ser-[protein] + CMP + H(+) => 3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14221", "l": "H2O + monomethyl sulfate = H(+) + methanol + sulfate", "d": []}, {"i": "EC:3.1.6.16", "l": "\"monomethyl-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52801", "l": "acetoacetyl-CoA + ATP + L-isoleucine => AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28899", "l": "glycine(in) + H(+)(in) = glycine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26191", "l": "1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9659611", "l": "ANO1 inhibitors bind ANO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199935", "l": "MSK1 activates CREB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647631", "l": "GSDMD (1-275) binds PIPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63481", "l": "NADP(+) + prostaglandin F2alpha => 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36807", "l": "H(+) + malonyl-CoA + octacosanoyl-CoA = 3-oxo-triacontanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49773", "l": "glycine + hexacosanoyl-CoA => CoA + H(+) + N-hexacosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810843", "l": "Envoplakin binds periplakin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29956", "l": "H(+)(in) + thymidine(in) => H(+)(out) + thymidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57763", "l": "2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382057", "l": "Release of novel PDGFs as latent factors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9609310", "l": "β-blockers bind ADRB1,2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2464822", "l": "RDH12 reduces atRAL to atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19672", "l": "GTP + H2O <=> GDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424485", "l": "Release of p-PLCG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102775", "l": "6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone synthase activity", "d": ["Catalysis of the reaction: 2 H+ + isovaleryl-CoA + 3 malonyl-CoA = 6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone + 4 coenzyme A + 3 carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18242", "l": "D-lysine => (2R,5S)-2,5-diaminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210805", "l": "Removal of miRNA passenger strand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64830", "l": "3-hydroxy-benzyl acetate + CoA => 3-hydroxybenzyl alcohol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44665", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10830", "l": "AMP + anthraniloyl-CoA + diphosphate => anthranilate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23445", "l": "(S)-lactate + NAD(+) => H(+) + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17543", "l": "an aromatic aldehyde + H2O2 => an aromatic primary alcohol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46056", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (11E,13Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73717", "l": "ATP(out) + dATP(in) => ATP(in) + dATP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31002", "l": "(S)-2,3-epoxysqualene <=> cucurbitadienol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52685", "l": "NAD(+) + pyridoxine => H(+) + NADH + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57329", "l": "acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] => CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48025", "l": "1,2,3-tripropanoylglycerol + H2O => dipropanoylglycerol + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432054", "l": "Aquaporin-1 passively transports water out of cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.203", "l": "\"uronate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29949", "l": "H(+)(out) + L-rhamnopyranose(out) => H(+)(in) + L-rhamnopyranose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36404", "l": "a cholesterol ester + H2O => a fatty acid + cholesterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749590", "l": "ASA- acetylates ALB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9715357", "l": "crizotinib-resistant ALK mutants don't bind crizotinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008782", "l": "adenosylhomocysteine nucleosidase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70362", "l": "3-oxosphinganine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787820", "l": "IL34 dimer binds CSF1R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659554", "l": "KCNQ4 transports K+ from the cytosol to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15504", "l": "2 L-glutamate + NADP(+) <=> 2-oxoglutarate + H(+) + L-glutamine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58820", "l": "H(+) + malonate + Na(+)(in) = acetate + CO2 + Na(+)(out)", "d": []}, {"i": "EC:7.2.4.4", "l": "\"biotin-dependent malonate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018630", "l": "3,5-xylenol methylhydroxylase activity", "d": ["Catalysis of the reaction: 3-hydroxytoluene + NADH + O2 = NAD+ + OH- + 3-hydroxybenzyl alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74796", "l": "N-methyl-(R)-salsolinol(in) => N-methyl-(R)-salsolinol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-217255", "l": "FMO1:FAD N-oxidises TAM (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35236", "l": "H(+)(out) + tetracycline(in) => H(+)(in) + tetracycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57161", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2 => (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419351", "l": "PAF receptor binds platelet activating factor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40236", "l": "coenzyme B + coenzyme M + fumarate => coenzyme M-coenzyme B heterodisulfide + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102752", "l": "1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)", "d": ["Catalysis of the reaction: a glucosylated glycogenin = a glycogen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22858", "l": "(7S)-O-acetylsalutaridinol + CoA => (7S)-salutaridinol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48224", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.13", "l": "\"D-alanine--poly(phosphoribitol) ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72310", "l": "L-glutamate(in) + taurocholate(out) <=> L-glutamate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004492", "l": "methyl/ethyl malonyl-CoA decarboxylase activity", "d": ["Catalysis of the reaction: (S)-methylmalonyl-CoA + H+ = CO2 + propanoyl-CoA or (2S)-ethylmalonyl-CoA + H+ = butanoyl-CoA + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1011598", "l": "DOCKs bind to RhoGEFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69050", "l": "6-hydroxyhexanoate + H(+) => H2O + hexano-6-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672817", "l": "Active MTORC1 binds the ULK1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15032", "l": "D-mannitol + NAD(+) <=> D-mannose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15498", "l": "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate => 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67502", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55673", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine => 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022872", "l": "protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannitol(out) = protein histidine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25358", "l": "2-hydroxyphytanoyl-CoA <=> 2,6,10,14-tetramethylpentadecanal + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033701", "l": "dTDP-galactose 6-dehydrogenase activity", "d": ["Catalysis of the reaction: dTDP-D-galactose + 2 NADP+ + H2O = dTDP-D-galacturonate + 2 NADPH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611721", "l": "β1-agonists bind ADRB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70439", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2 = a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.116", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905056", "l": "P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration", "d": ["A calcium-transporting P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944230", "l": "Association of procollagen type XVIII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40323", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031688", "l": "A2B adenosine receptor binding", "d": ["Binding to an A2B adenosine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35281", "l": "3-oxooctadecanoyl-CoA + CoA => acetyl-CoA + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17469", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]", "d": []}, {"i": "EC:2.3.1.135", "l": "\"phosphatidylcholine--retinol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40091", "l": "26-hydroxyhexacosanoate + NAD(+) = 26-oxohexacosanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033990", "l": "ectoine synthase activity", "d": ["Catalysis of the reaction: N(4)-acetyl-L-2,4-diaminobutyrate = ectoine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42942", "l": "5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in tRNA precursor + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.382", "l": "\"ketol-acid reductoisomerase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29297", "l": "aldehydo-D-galacturonate(in) + H(+)(in) => aldehydo-D-galacturonate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43460", "l": "dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-376887", "l": "2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33391", "l": "C20 sphinganine 1-phosphate + H2O = C20 sphinganine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16672", "l": "H2O + NAD(+) + xanthine <=> H(+) + NADH + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399711", "l": "Activation of Ca impermeable AMPA receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65060", "l": "NADP(+) + taurochenodeoxycholate = 7-oxotaurolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24185", "l": "4,5-dihydroxyphthalate + H(+) => 3,4-dihydroxybenzoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20815", "l": "(3S)-citryl-CoA <=> acetyl-CoA + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41797", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57844", "l": "fraxetin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form)", "d": []}, {"i": "EC:1.14.14.164", "l": "\"fraxetin 5-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048000", "l": "isoflavone 3'-hydroxylase activity", "d": ["Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36588", "l": "an aldopyranose + NADP(+) => aldono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010647", "l": "ROBO3.1 binds AKAP5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41391", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659820", "l": "RB1 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240787", "l": "E2F1/2/3 stimulates SUZ12 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004013", "l": "adenosylhomocysteinase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24249", "l": "glyoxylate + L-alanine => glycine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42447", "l": "L-aspartate + NADP(+) <=> H(+) + iminosuccinate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60050", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+) => a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0052666", "l": "tRNA (cytosine-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylcytosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950782", "l": "p-STAT1 binds p-STAT3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033984", "l": "indole-3-glycerol-phosphate lyase activity", "d": ["Catalysis of the reaction: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13267", "l": "1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine => 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071253", "l": "connexin binding", "d": ["Binding to a connexin, any of a group of related proteins that assemble to form gap junctions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928657", "l": "MMP2,9 cleave EPHB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34908", "l": "molybdate(in) => molybdate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54417", "l": "5alpha-campestan-3-one + NADP(+) => campest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938231", "l": "RUNX1:CBFB binds CREBBP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9676257", "l": "Formation of the SET1A complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381087", "l": "Dimerization of PERK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31271", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 = CO2 + H2O + NAD(+) + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31702", "l": "4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] <=> 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67997", "l": "(Z)-1,2-dichloroethene + AH2 => A + chloride + chloroethene + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30268", "l": "2 monodehydro-L-ascorbate radical => L-ascorbate + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798347", "l": "E2F7 and E2F8 homo- and heterodimers bind the E2F1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24511", "l": "NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42226", "l": "AH2 + androst-4-ene-3,17-dione => A + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9815529", "l": "nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgenomic RNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53135", "l": "A + a 3-oxo-Delta(4)-steroid <=> a 3-oxo-Delta(1,4)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5606996", "l": "Soluble PROCR binds activated protein C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392752", "l": "Phosphorylation of L1 by CK-II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77609", "l": "Binding of APOBEC-1 to form editosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63770", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine => 2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710101", "l": "CASP4, CASP5 cleave GSDMD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675198", "l": "Activated MAPKs phosphorylate BRAF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654163", "l": "Activated FGFR4 binds PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-507870", "l": "Aquaporins passively transport water out of cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005055", "l": "laminin receptor activity", "d": ["Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189069", "l": "sucrose + H2O => glucose + fructose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0102175", "l": "3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity", "d": ["Catalysis of the reaction: a 3beta-hydroxysteroid-4alpha-carboxylate + NAD+ = a 3-oxosteroid + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247837", "l": "WNT ligands traffic to the Golgi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52584", "l": "chenodeoxycholoyl-CoA + NAD(+) = 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62275", "l": "4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904121", "l": "phosphatidylethanolamine transfer activity", "d": ["Removes phosphatidylethanolamine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-421831", "l": "trans-Golgi Network Coat Assembly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807872", "l": "Active ARF recruits coatomer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61746", "l": "stevioside + UDP => steviolbioside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44913", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH => (3E)-hexenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37068", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61631", "l": "5-aminopentanal <=> 1-piperideine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111879", "l": "PIP2 hydrolysis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33467", "l": "5-dehydroepisterol + H(+) + NADPH + O2 = ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13187", "l": "hydroxymethylbilane + 4 NH4(+) => H2O + 4 porphobilinogen", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203070", "l": "Association of profilin with monomeric actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20497", "l": "a 2-arylethylamine + acetyl-CoA = an N-acetyl-2-arylethylamine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30973", "l": "all-trans-lycopene => 7,7',9,9'-tetra-cis-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36802", "l": "a ribonucleoside 5'-diphosphate + H2O <=> a ribonucleoside 5'-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62620", "l": "[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O", "d": []}, {"i": "EC:1.11.1.24", "l": "\"thioredoxin-dependent peroxiredoxin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5221061", "l": "TDG excises 5-carboxylcytosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.140", "l": "\"gluconate/galactonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56323", "l": "a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose <=> an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65235", "l": "3-hydroxydodecanoyl-CoA + H2O <=> 3-hydroxydodecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651789", "l": "LIG1 bound to POLB ligates SSB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199043", "l": "LILRs interact with MHC Class I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69944", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55457", "l": "ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56251", "l": "1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1170539", "l": "Prolactin receptor is internalized (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34401", "l": "9-cis-10'-apo-beta-carotenal + beta-ionone => 9-cis-beta-carotene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696605", "l": "USP12, USP26 deubiquitinate AR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75014", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate <=> 9-(9Z-octadecenoyloxy)-octadecanoate + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008158", "l": "hedgehog receptor activity", "d": ["Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64316", "l": "2 dihydrogeodin + 2 H(+) + O2 = 2 (+)-geodin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61922", "l": "(2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate => (2R,4S)-ketoconazole(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49511", "l": "phosphinomethylmalate <=> 2-(phosphinatomethylidene)butanedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15567", "l": "a carboxylate + an L-alpha-amino acid => an N-acyl-L-amino acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49612", "l": "(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.399", "l": "\"2-oxoglutarate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209840", "l": "Two DITs combine to form thyroxine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62768", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114553", "l": "Activation of conventional Protein Kinase C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23369", "l": "H(+) + phenylglyoxylate => benzaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64380", "l": "3 A + phytyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1222491", "l": "Lactoferrin scavenges iron ions (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55924", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047185", "l": "N-acetylneuraminate 4-O-acetyltransferase activity", "d": ["Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-4-O-acetylneuraminate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62392", "l": "levoglucosan + NAD(+) = 3-dehydrolevoglucosan + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.425", "l": "\"levoglucosan dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51288", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate = (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229343", "l": "AXIN is phosphorylated in the destruction complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72258", "l": "dopamine + S-adenosyl-L-methionine <=> 3-methoxytyramine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67275", "l": "1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + 9-hydroxy-(10E,12Z)-octadecadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106625", "l": "Duplex siRNA is loaded into Argonaute (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132064", "l": "Antigen bound antibody interacts with C1complement complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54113", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + selina-4(15),7(11)-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186798", "l": "GAP binds to PDGF-beta receptors only (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53304", "l": "AH2 + 2 ATP + 2 cob(II)alamin = A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646347", "l": "PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25780", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate", "d": []}, {"i": "EC:1.1.1.336", "l": "\"UDP-N-acetyl-D-mannosamine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0015125", "l": "bile acid transmembrane transporter activity", "d": ["Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66870", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate => 3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20621", "l": "ATP + H2O + Zn(2+)(in) = ADP + H(+) + phosphate + Zn(2+)(out)", "d": []}, {"i": "EC:7.2.2.12", "l": "\"P-type Zn(2+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981892", "l": "Active G alpha (z) binds RGS proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420233", "l": "VIP receptors bind VIP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71849", "l": "LDH tetramer reduces PYR to LACT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52865", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46507", "l": "dodecanoyl-AMP + holo-[ACP] <=> AMP + dodecanoyl-[ACP] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24713", "l": "2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose <=> L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46007", "l": "2-methylpropanal + CoA + NAD(+) <=> 2-methylpropanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.16", "l": "\"formyl-CoA transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34951", "l": "3-hydroxypropanoate(out) = 3-hydroxypropanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58681", "l": "A + FADH2 => AH2 + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11814", "l": "formaldehyde + H(+) + H2O2 + hydrogen sulfide => H2O + methanethiol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196753", "l": "2xPPCS ligates PPanK with Cys (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42764", "l": "formate + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = CO2 + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.17.98.3", "l": "\"formate dehydrogenase (coenzyme F420)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30391", "l": "4-methylsulfanyl-2-oxobutanoate + L-glutamine = 2-oxoglutaramate + L-methionine", "d": []}, {"i": "EC:2.6.1.117", "l": "\"L-glutamine--4-(methylsulfanyl)-2-oxobutanoate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0046923", "l": "ER retention sequence binding", "d": ["Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975861", "l": "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72792", "l": "bilirubin-glucuronoside(out) => bilirubin-glucuronoside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64732", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734193", "l": "Defective APRT does not convert adenine to AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36994", "l": "phosphate + UMP <=> alpha-D-ribose 1,5-bisphosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.97", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733545", "l": "Bile salts and acids bind ALB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112342", "l": "Inactivation of MAP2K1 by CDK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56975", "l": "(R)-3-hydroxy-2-methylpropanoate + NAD(+) <=> (R)-methylmalonate semialdehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40140", "l": "(9Z)-octadecenoyl-CoA + H2O => (9Z)-octadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043761", "l": "archaetidylserine synthase activity", "d": ["Catalysis of the reaction: CDP-digeranylgeranylglycerol + L-serine = archaetidylserine + CMP."]}, {"i": "EC:2.7.8.38", "l": "\"archaetidylserine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010292", "l": "GTP:GDP antiporter activity", "d": ["Catalysis of the reaction: GTP(out) + GDP(in) = GTP(in) + GDP(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35966", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A <=> fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60565", "l": "2-deoxy-D-glucose + ATP => 2-deoxy-D-glucose 6-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761120", "l": "BHLHE22 recruits PRDM8 to intron 1 of CDH11 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14030", "l": "A + H2O + selenite => AH2 + selenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63655", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005497", "l": "androgen binding", "d": ["Binding to an androgen, a male sex hormone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167408", "l": "The high affinity receptor complex binds to G-protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75954", "l": "2-oxoglutarate + O2 + oripavine <=> CO2 + formaldehyde + neomorphinone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63570", "l": "beta-casomorphin-6 + L-isoleucine => beta-casomorphin-7 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42474", "l": "2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+) => dibenzo-p-dioxin + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032574", "l": "5'-3' RNA helicase activity", "d": ["Unwinding of an RNA helix in the 5' to 3' direction, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218836", "l": "PTK2beta binds alphaVbeta3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110218", "l": "Cleavage of uracil by TDG glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426223", "l": "Cation influx mediated by TRPC3/6/7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19482", "l": "acetyl-CoA + succinyl-CoA => 3-oxoadipyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.102", "l": "\"C-terminal processing peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769383", "l": "CBY1 binds beta-catenin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17083", "l": "(E)-isomethyleugenol + H(+) + S-adenosyl-L-homocysteine => (E)-isoeugenol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018472", "l": "1-hydroxy-2-naphthaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 1-hydroxy-2-naphthaldehyde + NAD+ + H2O = NADH + H+ + 1-hydroxy-2-naphthoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13470", "l": "A + H2O + thymine => 5-methylbarbiturate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29561", "l": "1-phospho-alpha-D-glucuronate + 2 H(+) + UMP => H2O + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854466", "l": "VLDLR binds RELN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64655", "l": "(E)-4-coumaraldehyde + CoA + NADP(+) <=> (E)-4-coumaroyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68245", "l": "L-phenylalanine(in) + Na(+)(in) => L-phenylalanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20565", "l": "(2E)-geranyl diphosphate + H2O = (1S,2S,4R)-endo-fenchol + diphosphate", "d": []}, {"i": "EC:4.2.3.10", "l": "\"(-)-endo-fenchol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626681", "l": "Recruitment of transition zone proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28291", "l": "(2E,6E)-farnesyl diphosphate + H2O => (5S,9S,10S)-drim-7-en-11-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674095", "l": "PDGFRs bind type II TKI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60862", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12670", "l": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] => L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14967", "l": "a carboxylate + H(+) + phosphate => an acyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44904", "l": "alpha-D-glucose 6-phosphate + H2O = alpha-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65489", "l": "3 ATP => 2',3',3'-c-tri-AMP + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210298", "l": "Interaction of DAP12 and KIR3DS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56746", "l": "(3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28318", "l": "scutellarein + UDP-alpha-D-glucuronate = scutellarin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28014", "l": "S-adenosyl-L-methionine + thiocyanate = methyl thiocyanate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.n4", "l": "\"thiocyanate methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63999", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55339", "l": "a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine <=> a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27392", "l": "(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O <=> pyruvate + salicylaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867613", "l": "PICALM binds R-SNAREs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32245", "l": "D-ribulose 1,5-bisphosphate => alpha-D-ribose 1,5-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36231", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46945", "l": "(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) => H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55529", "l": "H(+) + H2O + L-tyrosine + O2 => (4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35114", "l": "2-dehydro-L-idonate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44630", "l": "H(+) + L-anticapsin + NADH => L-dihydroanticapsin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909552", "l": "Phosphorylation of STAT1 at Ser727 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68254", "l": "L-tryptophan(out) + Na(+)(out) => L-tryptophan(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11890", "l": "a carboxylate + 2 H(+) + NADPH => an aldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62747", "l": "H2O + mevastatin <=> (S)-2-methylbutanoate + compactin diol lactone + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71607", "l": "(S)-malate(in) + phosphate(out) = (S)-malate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19770", "l": "phaseollidin hydrate => H2O + phaseollidin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15130", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56452", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = 12-epi-hapalindole U", "d": []}, {"i": "EC:5.5.1.32", "l": "\"12-epi-hapalindole U synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60133", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 => a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824196", "l": "HES7 binds the LFNG gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27413", "l": "2-oxoglutarate + codeine + O2 = CO2 + formaldehyde + morphine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4086083", "l": "SUMOylation of ING2 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49457", "l": "(2S)-2-amino-4-deoxychorismate + H2O => (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64167", "l": "2-methyl-L-serine <=> formaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75201", "l": "1-carboxybiuret + NH4(+) => H2O + triuret", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033445", "l": "AGU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AGU codon."]}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0004311", "l": "farnesyltranstransferase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39147", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030591", "l": "2'-deoxyguanosine DNA ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of the ADP-ribose group of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34679", "l": "ATP + methylphosphonate = adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate", "d": []}, {"i": "EC:2.7.8.37", "l": "\"alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68774", "l": "diphosphate + germacrene C => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64085", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) => 2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41032", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64547", "l": "acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine <=> 8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11170", "l": "3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH => 3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019992", "l": "diacylglycerol binding", "d": ["Binding to a diacylglycerol, a diester of glycerol and two fatty acids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015561", "l": "rhamnose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: rhamnose(out) + H+(out) = rhamnose(in) + H+(in)."]}, {"i": "TCDB:2.A.7.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76010", "l": "(3R)-hydroxybutanoate pentamer + H2O <=> (3R)-hydroxybutanoate tetramer + (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65002", "l": "AMP + H(+) + octanoyl-[ACP] => holo-[ACP] + octanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045514", "l": "interleukin-16 receptor binding", "d": ["Binding to an interleukin-16 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48299", "l": "H2O + prostaglandin E2 1-glyceryl ester <=> glycerol + H(+) + prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51150", "l": "an aldehyde + 2 H(+) + 2 reduced [azurin] => a primary alcohol + 2 oxidized [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30314", "l": "7-methylxanthine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665761", "l": "FMNL3 binds RHOC:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622980", "l": "FOXO1 binds NPY gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70282", "l": "H2O + stachyose <=> D-galactose + raffinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42174", "l": "(8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O => (11Z)-eicosenoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72863", "l": "3',3',3'-cAAG + H2O = G[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683593", "l": "ATG7:ATG3:LC3 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354124", "l": "Phosphorylation of pPTK2 by SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74036", "l": "D-serine(out) + L-alanine(in) => D-serine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689111", "l": "PARK2 autoubiquitinates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10718", "l": "1D-myo-inositol 3-phosphate => D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160935", "l": "SMURF1 ubiquitinates RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37460", "l": "1D-myo-inositol hexakisphosphate + ATP => 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21922", "l": "Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928614", "l": "EFNB:GRB4 binds GIT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61607", "l": "[DsbA protein]-dithiol + [DsbB protein]-disulfide <=> [DsbA protein]-disulfide + [DsbB protein]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866304", "l": "pre-VLDL binds lipids to form VLDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863463", "l": "STON2 binds SYT proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12419", "l": "beta-alanyl-CoA <=> acryloyl-CoA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41091", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31164", "l": "(3S)-hydroxyhexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803890", "l": "SFN dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34411", "l": "cannabigerolate + O2 = cannabidiolate + H2O2", "d": []}, {"i": "EC:1.21.3.8", "l": "\"cannabidiolic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66427", "l": "ATP + H2O + leukotriene B4(in) <=> ADP + H(+) + leukotriene B4(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74256", "l": "H2O + L-homoseryl-tRNA(Ser) => H(+) + L-homoserine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004100", "l": "chitin synthase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004452", "l": "isopentenyl-diphosphate delta-isomerase activity", "d": ["Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70088", "l": "methanol + o-quinone methide => hydroxyclavatol methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106323", "l": "(S)-limonene 1,2-monooxygenase NADPH activity", "d": ["Catalysis of the reaction: (4S)-limonene + NADPH+= + H+ + O2 = NADP+ + H2O + (4S)-limonene-1,2-epoxide."]}, {"i": "RHEA:26085", "l": "(4S)-limonene + H(+) + NADPH + O2 = H2O + limonene 1,2-epoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173680", "l": "Activation of C5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11051", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-organyl-2-lyso-sn-glycero-3-phospholipid <=> 1-O-alkyl-sn-glycero-3-phosphocholine + a 1-organyl-2-acetyl-sn-glycero-3-phospholipid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61743", "l": "steviolmonoside + UDP-alpha-D-glucose <=> H(+) + steviolbioside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51234", "l": "2-glyceryl-prostaglandin D2 => 2-glyceryl-prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420265", "l": "AMY1-3 bind IAPP(34-70) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67616", "l": "8-oxo-GTP + H2O = 8-oxo-GMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59943", "l": "2-methyloctadecanoyl-CoA + H2O <=> 2-methyloctadecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70354", "l": "beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O <=> beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13680", "l": "D-ribulose 5-phosphate <=> D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011941", "l": "Estrogen-responsive BCL2 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-874087", "l": "SGT1 binds HSP90 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380508", "l": "Translocation of NuMA to the centrosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848250", "l": "ACBD6 binds LCFA-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694409", "l": "Nucleotide exchange on RAB1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44521", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63436", "l": "1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66808", "l": "5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH = 7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015230", "l": "FAD transmembrane transporter activity", "d": ["Enables the directed movement of flavin-adenine dinucleotide (FAD) from one side of a membrane to the other. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12128", "l": "2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.4.7.1", "l": "\"glutamate synthase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451858", "l": "YKI binds to HPO homodimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61430", "l": "cis-trans-nepetalactone + H(+) + NADH => cis-trans-nepetalactol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134953", "l": "DHX36 or DHX9 binds MyD88 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73319", "l": "(2R,3S)-piscidate + (E)-4-coumaroyl-CoA = cimicifugate K + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37038", "l": "H2O + L-2-aminopentanoate + NAD(+) <=> 2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809680", "l": "MTMR12 binds MTM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45579", "l": "(2R)-ethylmalonyl-CoA <=> (2S)-methylsuccinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683764", "l": "Spike trimer translocates to ERGIC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130706", "l": "MHC class II antigen processing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58563", "l": "15alpha-stemmadenine intermediate II + NADP(+) <=> 15alpha-stemmadenine intermediate I + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9608288", "l": "Defective MUTYH mutants do not bind adenine mispaired with 8-oxoguanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10349", "l": "5-oxo-L-proline + ATP + 2 H2O => ADP + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20938", "l": "3-methyl-2-oxobutanoate + H2O => 2,3-dihydroxy-3-methylbutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72448", "l": "a dicarboxylate(in) + estrone 3-sulfate(out) => a dicarboxylate(out) + estrone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686335", "l": "CSF2RA:CSF2RB binds SFTPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9650858", "l": "Meglitinides bind ABCC8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102457", "l": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose <=> H+ + cyanidin 3,7-di-O-beta-D-glucoside betaine + vanillate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.68", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22250", "l": "7,8-dihydroxykynurenate + H(+) + NADH => 7,8-dihydro-7,8-dihydroxykynurenate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042929", "l": "ferrichrome transmembrane transporter activity", "d": ["Enables the directed movement of a ferrichrome from one side of a membrane to the other. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013023", "l": "RHOB GEFs activate RHOB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39981", "l": "H(+) + N-methylpavine + S-adenosyl-L-homocysteine => (+-)-pavine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37604", "l": "(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047586", "l": "5'-acylphosphoadenosine hydrolase activity", "d": ["Catalysis of the reaction: 5'-acylphosphoadenosine + H2O = AMP + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374896", "l": "Uptake of Noradrenaline (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65388", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229213", "l": "RCVRN:Ca2+ binds to and inhibits GRK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10312", "l": "H(+) + NADH + O2 + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)", "d": []}, {"i": "EC:1.14.12.15", "l": "\"terephthalate 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68682", "l": "3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(beta-D-glucuronate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24543", "l": "A + D-glucose <=> AH2 + D-glucono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28417", "l": "gamma-L-glutamylputrescine + H2O + O2 <=> 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63307", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62760", "l": "4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782138", "l": "ERCC5 and RPA bind TC-NER site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.15.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57582", "l": "S-methyl-1-thiol-D-ribulose 5-phosphate => S-methyl-5-thio-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17494", "l": "A + glycerol => AH2 + dihydroxyacetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5591086", "l": "SERPINA5 binds activated protein C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74421", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in) => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624798", "l": "LBR binds KPNB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73868", "l": "serotonin(out) => serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68068", "l": "a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase] = a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76456", "l": "O-atom dealkylation of dextromethorphan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322434", "l": "XIAP dissociates from ub-TLE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0005550", "l": "pheromone binding", "d": ["Binding to a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75360", "l": "L-mimosine => 2-aminoprop-2-enoate + 3-hydroxy-4H-pyrid-4-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53087", "l": "[(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59491", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate <=> ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69929", "l": "adenosine(in) + Na(+)(in) => adenosine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605724", "l": "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10239", "l": "trans-2-coumarate + UDP-alpha-D-glucose <=> H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48892", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050458", "l": "decylhomocitrate synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + H2O + lauroyl-CoA = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1606564", "l": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63363", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2 <=> (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69150", "l": "H2O2 + NH4(+) + spermine monoaldehyde => H2O + O2 + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420911", "l": "Formation of PPAT dimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0031739", "l": "cholecystokinin receptor binding", "d": ["Binding to a cholecystokinin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33896", "l": "NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose => H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65289", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74103", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047680", "l": "aryl-acylamidase activity", "d": ["Catalysis of the reaction: anilide + H2O = a carboxylate + aniline + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25364", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) => H(+) + momilactone A + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63841", "l": "[thioredoxin]-dithiol + tert-butyl hydroperoxide => [thioredoxin]-disulfide + H2O + tert-butanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54859", "l": "H(+) + NADPH + O2 + octan-3-one <=> ethyl hexanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59617", "l": "beta-alanyl-L-arginine + H2O => beta-alanine + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176116", "l": "Recruitment and activation of Chk1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47373", "l": "a quinone + D-glucose => a quinol + D-glucono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710959", "l": "p-STAT1 dimer binds KPNA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-500708", "l": "GRIK3 homomer binds glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10336", "l": "citrate = D-threo-isocitrate", "d": []}, {"i": "EC:4.2.1.3", "l": "\"aconitate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28979", "l": "H(+)(out) + nitrite(in) = H(+)(in) + nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691004", "l": "XPC binds RAD23 and CETN2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36805", "l": "genistein + H(+) + H2O => 2-hydroxy-2,3-dihydrogenistein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848150", "l": "STAT3 binds SOCS3 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694506", "l": "Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41182", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51327", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74002", "l": "dimethylallyl diphosphate + quinolinone B <=> diphosphate + peniprequinolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693598", "l": "ATM phosphorylates NBN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5099899", "l": "WNT5A binds FZD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404135", "l": "RBP4 binds atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52335", "l": "2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] <=> 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44098", "l": "CoA + decanyl hexadecanoate => decan-1-ol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225978", "l": "Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48161", "l": "3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] => epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.2", "l": "\"beta-amylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16393", "l": "H2O + juvenile hormone II = H(+) + juvenile hormone II carboxylate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57765", "l": "2,6-dinitrotoluene + NADH + O2 => 3-methyl-4-nitrocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062185", "l": "secalciferol 1-monooxygenase activity", "d": ["Catalysis of the reaction:2 H+ + O2 + 2 reduced [adrenodoxin] + secalciferol = calcitetrol + H2O + 2 oxidized [adrenodoxin]."]}, {"i": "RHEA:49064", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol = calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785213", "l": "LIPC dimer binds heparin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74626", "l": "AMP(in) + UMP(out) <=> AMP(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13405", "l": "4-coumaroyl-CoA + agmatine = CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide", "d": []}, {"i": "EC:2.3.1.64", "l": "\"agmatine N(4)-coumaroyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41061", "l": "1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433395", "l": "Dimerization of sSCF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5669250", "l": "PAK1 phosphorylates FLNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43708", "l": "ATP + H(+) + hexadecanoate = diphosphate + hexadecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56056", "l": "genistein + UDP-alpha-D-glucose = genistein 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48243", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b <=> CMP + ganglioside GT1b + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420883", "l": "Opsins act as GEFs for G alpha-t (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11954", "l": "2-hydroxy-3-oxopropanoate => 3-hydroxypyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685605", "l": "SLAMF7 binds SLAMF7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61572", "l": "(11Z,14Z)-eicosadienoate + O2 = (15S)-hydroperoxy-(11Z,13E)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874082", "l": "MET phosphorylates PTK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692495", "l": "BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169402", "l": "ISGylation of E2 conjugating enzymes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-994148", "l": "LRRC16A binds F-actin capping protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44863", "l": "(R)-carnitine + 4,8-dimethylnonanoyl-CoA <=> CoA + O-4,8-dimethylnonanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58471", "l": "2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350578", "l": "NQO1 interaction with ODC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74258", "l": "XDH oxidizes xanthine to form urate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759325", "l": "NFE2L2 binds the GSTA3 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65720", "l": "2-oxoglutarate + butyl sulfate + O2 = butanal + CO2 + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679029", "l": "C-ter TLR7 dimer binds HCQ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749590", "l": "ASA- acetylates ALB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29628", "l": "alpha-maltohexaose + beta-maltose => alpha-maltoheptaose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2197588", "l": "NICD2 binds RBPJ and MAML in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852324", "l": "GTSE1 binds PLK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380780", "l": "Activation of Src (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33793", "l": "beta-D-fructose + beta-D-glucose 6-phosphate => H2O + sucrose 6(F)-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34655", "l": "C30 botryococcene + 2 S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.263", "l": "\"botryococcene C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28244", "l": "5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + pratensein + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617864", "l": "HOXD4 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14766", "l": "coelenterazine h + O2 => CO2 + excited coelenteramide h monoanion + H(+) + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18475", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP => 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73409", "l": "(S,S)-tartrate(out) + sulfate(in) => (S,S)-tartrate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68130", "l": "a fatty acid phytyl ester + CoA => a fatty acyl-CoA + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015541", "l": "secondary active cyanate transmembrane transporter activity", "d": ["Enables the transfer of cyanate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201322", "l": "TIRAP is phosphorylated by BTK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72953", "l": "butanoate(in) + 2 Na(+)(in) => butanoate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18877", "l": "myo-inositol + S-adenosyl-L-methionine = 1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.39", "l": "\"inositol 3-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55510", "l": "11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54205", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 => 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004401", "l": "histidinol-phosphatase activity", "d": ["Catalysis of the reaction: L-histidinol phosphate + H2O = L-histidinol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692755", "l": "CDK1 phosphorylates MAPK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629679", "l": "PDE3A inhibitors bind PDE3A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35027", "l": "ATP + H2O + tungstate(in) = ADP + H(+) + phosphate + tungstate(out)", "d": []}, {"i": "EC:7.3.2.6", "l": "\"ABC-type tungstate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70120", "l": "6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43399", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41642", "l": "3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate => 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48966", "l": "[thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O => 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163773", "l": "Phosphorylation of PF2K-Pase by PKA catalytic subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17194", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27289", "l": "(S)-acetoin + NAD(+) <=> diacetyl + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35670", "l": "a triacylglycerol + H2O <=> a 1,2-diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783681", "l": "LIF binds LIFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004699", "l": "calcium-independent protein kinase C activity", "d": ["Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium."]}, {"i": "REACT:R-HSA-5607740", "l": "PKC-delta phosphorylates CARD9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429699", "l": "CERT1-2 binds ceramide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114558", "l": "Thrombin-activated PARs activate Gq (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19992", "l": "S-methyl-5-thio-alpha-D-ribose 1-phosphate <=> S-methyl-5-thio-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939201", "l": "ESR dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18950", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202969", "l": "Caspase mediated cleavage of beta-catenin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70548", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + UDP-alpha-D-glucose => 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35023", "l": "hydroquinone O-beta-D-glucopyranoside(out) = hydroquinone O-beta-D-glucopyranoside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9617927", "l": "FOXO4 binds ATXN3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47635", "l": "H2O + L-arginine + NAD(+) <=> 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39614", "l": "3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033222", "l": "xylose binding", "d": ["Binding to the D- or L-enantiomer of xylose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75787", "l": "GTP(in) = GTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20508", "l": "an alpha-(gamma-L-glutamyl)-L-amino acid <=> 5-oxo-L-proline + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21776", "l": "(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.28", "l": "\"3alpha,7alpha-dihydroxy-5beta-cholestanate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69449", "l": "(2E,6E)-farnesyl diphosphate + H2O => delta-cadinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944223", "l": "Association of procollagen type V (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26219", "l": "abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-182986", "l": "CBL-mediated ubiquitination of CIN85 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69510", "l": "H(+) + N-acetyl-D-glucosaminate => H2O + N-acetyl-D-glucosamino-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33620", "l": "ATP + CoA + tetradecanoate => AMP + diphosphate + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49339", "l": "2,2-dihydroxyspheroidene <=> H2O + spheroiden-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43833", "l": "5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA => 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61833", "l": "sitosterol + UDP-alpha-D-glucose => H(+) + sitosteryl 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20678", "l": "alizarin + UDP-alpha-D-glucose => 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69573", "l": "dIMP + inosine => 2'-deoxyinosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0047224", "l": "acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-D-galactosalaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69307", "l": "(Z)-glucotropeolin + H2O <=> (Z)-phenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68593", "l": "(6S)-5,6,7,8-tetrahydrofolate(out) + ATP + H2O => (6S)-5,6,7,8-tetrahydrofolate(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198669", "l": "p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58093", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.18.-", "l": "\"Cysteine-type carboxypeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69973", "l": "(22S)-22-hydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034781", "l": "N-cyclohexylformamide amidohydrolase activity", "d": ["Catalysis of the reaction: N-cyclohexylformamide + OH- = cyclohexylamine + formate."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0061812", "l": "cyclic ADP-ribose hydrolase", "d": ["Catalysis of the reaction: cyclic ADP-ribose + H20 = ADP-ribose (ADPR)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209235", "l": "Phosphorylated BSK kinase transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9667619", "l": "AVPR1A,B,2 bind atosiban (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730902", "l": "Oligomerization of p-CARMA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43232", "l": "H2O + isatin = H(+) + isatinate", "d": []}, {"i": "EC:3.5.2.20", "l": "\"isatin hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1470010", "l": "Dimerization of STATs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74558", "l": "(S)-malate(out) <=> (S)-malate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098619", "l": "selenocysteine-tRNA ligase activity", "d": ["Catalysis of the reaction: tRNASec + L-Ser + ATP = Ser-tRNASec + AMP + diphosphate."]}, {"i": "REACT:R-HSA-2408526", "l": "tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210426", "l": "Glutamate synaptic vesicle docking and priming (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1454916", "l": "The ABCC family mediates organic anion transport (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419166", "l": "GEFs activate RhoA,B,C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73586", "l": "CTP(out) + UDP(in) <=> CTP(in) + UDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14712", "l": "a 3-oxo-Delta(5)-steroid <=> a 3-oxo-Delta(4)-steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52078", "l": "(9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+) => 13-(9Z-hexadecenoyloxy)-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205649", "l": "p62 links damaged mitochondria to LC3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31830", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-gamma-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507870", "l": "Aquaporins passively transport water out of cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55322", "l": "2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein] => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928645", "l": "EPHB:NMDAR binds TIAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42344", "l": "H(+) + NADH + O2 + p-cumate = (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)", "d": []}, {"i": "EC:1.14.12.25", "l": "\"p-cumate 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75941", "l": "4-guanidinobutanoate + L-ornithine => 4-aminobutanoate + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005500", "l": "juvenile hormone binding", "d": ["Binding to a juvenile hormone, a sesquiterpenoid derivative that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12327", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine <=> L-asparagine + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706308", "l": "Active FLT3 binds to GRB10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64117", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54028", "l": "a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64907", "l": "GTP + 2 H2O <=> GMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977363", "l": "Factor H binds to C3bBb (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707690", "l": "BACH1 binds MAFK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51446", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0002161", "l": "aminoacyl-tRNA editing activity", "d": ["The hydrolysis of an incorrectly aminoacylated tRNA."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0015450", "l": "protein-transporting ATPase activity", "d": ["Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated."]}, {"i": "REACT:R-HSA-1222523", "l": "SodB gets secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2731141", "l": "Syndecan-1 binds fibronectin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391939", "l": "TP receptor can bind thromboxane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38327", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38646", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781899", "l": "USP13 binds SIAH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-139941", "l": "Binding of IP3 to IP3 receptor (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45542", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67095", "l": "ATP + docosanoate(in) + H2O <=> ADP + docosanoate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70684", "l": "(R)-normetanephrine + S-adenosyl-L-methionine => (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015045", "l": "rubredoxin-NAD(P)+ reductase activity", "d": ["Catalysis of the reaction: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043920", "l": "aminopropylagmatine ureohydrolase activity", "d": ["Catalysis of the reaction: N1-aminopropylagmatine + H2O = spermidine + urea."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140345", "l": "phosphatidylcholine flippase activity", "d": ["Catalysis of the movement of phosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65487", "l": "hexan-1-ol + hexanoyl-CoA <=> CoA + hexyl hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666008", "l": "SCAI binds SRF:MKL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42624", "l": "(Z)-3-ureidoacrylate + H(+) + H2O = (Z)-3-aminoacrylate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70952", "l": "D-serine + H2O + O2 => 3-hydroxypyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229138", "l": "MAPKAPK2/3-mediated removal of PRC1.4 complex stimulates p14ARF transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10352", "l": "an N-acetylarylalkylamine + H2O = acetate + an aralkylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23312", "l": "2 sucrose = 1(F)-beta-D-fructosylsucrose + D-glucose", "d": []}, {"i": "EC:2.4.1.99", "l": "\"sucrose:sucrose fructosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53649", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-corvol ether A + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140733", "l": "tRNA ligase activator activity", "d": ["Binds to and increases the activity of a tRNA ligase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38920", "l": "H2O + sphing-4-enine-phosphocholine => choline + H(+) + sphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033819", "l": "lipoyl(octanoyl) transferase activity", "d": ["Catalysis of the reaction: L-lysyl-[protein] + octanoyl-[ACP] = H+ + holo-[ACP] + N6-octanoyl-L-lysyl-[protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57284", "l": "a guanosine in RNA + methylglyoxal = an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418172", "l": "F2R binds ARRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71361", "l": "17beta-estradiol 17-sulfate(in) + 2 Na(+)(in) => 17beta-estradiol 17-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202443", "l": "Oligomerization of CARMA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607058", "l": "Activated protein C:PROCR binds F2R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70677", "l": "L-arginyl-L-phenylalanine + Met-enkephalin => H2O + Met-enkephalin-Arg-Phe", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12699", "l": "ADP + dGDP => ATP + dGMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730736", "l": "Monofunctional chemotherapeutic alkylating drugs produce 3-methyladenine in dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019706", "l": "protein-cysteine S-palmitoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40201", "l": "16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52620", "l": "3-methylbutanoyl-CoA = 2,2-dimethylpropanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3000327", "l": "PLK1 phosphorylates BORA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8963915", "l": "1,25(OH)2D binds VDR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43147", "l": "adenosine(22) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18632", "l": "ATP + NAD(+) <=> ADP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691421", "l": "BTK binds BTK inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63321", "l": "a glycerophospholipid(in) + ATP + H2O => a glycerophospholipid(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63643", "l": "(R)-N(6)-lipoyl-L-lysyl-[protein] + H2O + NAD(+) <=> 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.98.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193656", "l": "p75NTR interacts with RIP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64549", "l": "N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] => (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042008", "l": "interleukin-18 receptor activity", "d": ["Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953013", "l": "E2F7 binds E2F8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36752", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => beta-D-Gal-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437984", "l": "Phosphorylation of MKK3/MKK6 by activated TAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31060", "l": "H2O + imidazole-4-acetaldehyde + NAD(+) => 2 H(+) + imidazole-4-acetate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38948", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2429719", "l": "MCPH1 sequesters condensin II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47355", "l": "a hexanoate ester + H2O <=> an aliphatic alcohol + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48607", "l": "2,3-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] <=> 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982807", "l": "JAK2 phosphorylation of GHR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29900", "l": "ATP + D-xylose(out) + H2O => ADP + D-xylose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59209", "l": "ATP + H(+) + octadecanoate => diphosphate + octadecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71967", "l": "(S)-2-hydroxyglutarate(out) + 3 Na(+)(out) = (S)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13302", "l": "a 1,2-diacyl-sn-glycerol + a sterol => a 1-acyl-sn-glycerol + a sterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070530", "l": "K63-linked polyubiquitin modification-dependent protein binding", "d": ["Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74641", "l": "AMP(in) + CMP-N-acetyl-beta-neuraminate(out) => AMP(out) + CMP-N-acetyl-beta-neuraminate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675896", "l": "PI(3,5)P2 transports from the early endosome membrane to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655835", "l": "Expression of ELOVL6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38196", "l": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003962", "l": "cystathionine gamma-synthase activity", "d": ["Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033746", "l": "histone H3R2 demethylase activity", "d": ["Catalysis of the removal of the methyl group from a modified arginine residue at position 2 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44696", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42266", "l": "3-oxodecanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46457", "l": "5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH => 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54241", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229343", "l": "AXIN is phosphorylated in the destruction complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62816", "l": "4 monapinone E + O2 = 2 dinapinone E + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24900", "l": "3',3'-c-di-GMP + 2 diphosphate => 2 GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47563", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) <=> CMP + ganglioside GM1b (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55367", "l": "(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 6 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15318", "l": "a 2-deoxy-alpha-D-glucoside + H2O => 2-deoxy-D-glucose + an alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381608", "l": "cAMP activates EPAC2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52756", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25687", "l": "H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) => L-cysteinyl-tRNA(Cys) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19655", "l": "CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033826", "l": "xyloglucan 4-glucosyltransferase activity", "d": ["Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose on to a glucose residue in xyloglucan, forming a beta-1,4-D-glucosyl-D-glucose linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33515", "l": "2 5,6-dihydroxyindole + O2 = 2 H2O + 2 indole-5,6-quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032775", "l": "YAP1 binds TEAD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38688", "l": "(4R)-hydroxysphinganine(in) + ATP + H2O => (4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615910", "l": "SUMOylation of PCNA with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28955", "l": "aldehydo-D-glucuronate(in) + H(+)(in) = aldehydo-D-glucuronate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62677", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide => 6-thio-IMP + 7,8-dihydrofolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22104", "l": "2-oxoglutarate + nicotianamine = 3''-deamino-3''-oxonicotianamine + L-glutamate", "d": []}, {"i": "EC:2.6.1.80", "l": "\"nicotianamine aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62166", "l": "D-glucosamine + N-acetyl-D-glucosamine => beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71291", "l": "(R)-carnitine(out) + chloride(out) + 2 Na(+)(out) = (R)-carnitine(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942075", "l": "Peroxynitrite and carbon dioxide react to nitrosoperoxycarbonate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "58.369810610503507", "identifiers": [{"i": "GO:0016758", "l": "hexosyltransferase activity", "d": ["Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.4.1.-", "l": "\"Hexosyltransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25624", "l": "geranylgeranyl diphosphate <=> tuberculosinyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196417", "l": "Reduction of desmosterol to cholesterol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000433", "l": "SUMOylation of PML with SUMO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59189", "l": "L-histidine => D-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27927", "l": "UMP(in) => UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61885", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12387", "l": "5,6-dihydrouracil + O2 <=> H2O2 + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11343", "l": "5-guanidino-2-oxopentanoate + H(+) <=> 4-guanidinobutanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74712", "l": "Dissociation of IRS-P from insulin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10580", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371591", "l": "Trimerization of cytosolic HSF1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203553", "l": "eNOS binds NOSIP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626817", "l": "PKC phosphorylates NCF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12139", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) <=> a (2E,4E)-dienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2559439", "l": "CD14:LPS binds CR3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75194", "l": "2-dehydro-3-deoxy-L-fuconate + NAD(+) <=> 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12949", "l": "D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H2O", "d": []}, {"i": "EC:4.2.1.67", "l": "\"D-fuconate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030774", "l": "anthranilate N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = N-methylanthranilate + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665871", "l": "ADRM1 binds 26S proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114544", "l": "p115-RhoGEF activation of RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134946", "l": "DDX41 ubiquitination by TRIM21 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.143", "l": "\"diphosphate-purine nucleoside kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110311", "l": "POLZ extends translesion synthesis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2468040", "l": "Cohesin binds PDS5 and WAPAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66431", "l": "D-arabinose(out) + H(+)(out) <=> D-arabinose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015229", "l": "L-ascorbic acid transmembrane transporter activity", "d": ["Enables the transfer of L-ascorbate from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species."]}, {"i": "REACT:R-HSA-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75256", "l": "mangiferin + O2 => 3'-dehydromangiferin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201603", "l": "Caspase-mediated cleavage of PKC theta (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.112", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35540", "l": "cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 => albonoursin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38820", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69459", "l": "3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH <=> 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38773", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47621", "l": "2-ethylhexyl sulfate + 2-oxoglutarate + O2 => 2-ethylhexanal + CO2 + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12985", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}, {"i": "EC:2.4.1.68", "l": "\"glycoprotein 6-alpha-L-fucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852324", "l": "GTSE1 binds PLK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42463", "l": "dibenzofuran + H(+) + NADH + O2 <=> biphenyl-2,2',3-triol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28512", "l": "beta-D-glucose 6-phosphate + hydroquinone => arbutin 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53283", "l": "D-threose <=> D-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20772", "l": "2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin", "d": []}, {"i": "EC:2.5.1.9", "l": "\"riboflavin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40850", "l": "eicosanoyl-CoA + FAD + H(+) <=> (2E)-eicosenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849463", "l": "PTK6 phosphorylates SFPQ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28302", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + germacrene C", "d": []}, {"i": "EC:4.2.3.60", "l": "\"germacrene C synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12644", "l": "(2R)-3-phosphoglycerate + NAD(+) <=> 3-phosphooxypyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20834", "l": "ADP + guanine(in) + H(+) + phosphate => ATP + guanine(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50153", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66578", "l": "4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 4-isopropylphenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9656947", "l": "OGG1beta translocates to mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140594", "l": "xyloglucan-specific endo-beta-1,4-glucanase inhibitor activity", "d": ["Stops, prevents or reduces the activity of xyloglucan-specific endo-beta-1,4-glucanase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75587", "l": "11-O-acetylcyathatriol + UDP-alpha-D-glucose = erinacine Q2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211164", "l": "AKT phosphorylates FOXO1A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61788", "l": "ATP + holo-[peptidyl-carrier protein] + L-tryptophan = AMP + diphosphate + L-tryptophyl-[peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.73", "l": "\"L-tryptophan--[L-tryptophyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20795", "l": "ATP + L-lysine + tRNA(Lys) <=> AMP + diphosphate + L-lysyl-tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67665", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O => 1,2-diacyl-sn-glycero-3-phosphoethanolamine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69882", "l": "6alpha-hydroxycastasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> castasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34012", "l": "5-dehydroepisterol + 2 H2O + NADP(+) => ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41807", "l": "3-oxobutanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxybutanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56111", "l": "genistein + O2 + reduced [NADPH--hemoprotein reductase] <=> 2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53366", "l": "H(+) + NADH + uridine(47) in tRNA => 5,6-dihydrouridine(47) in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034881", "l": "citrazinate hydrolase activity", "d": ["Catalysis of the reaction: citrazinate + H2O = cis-aconitamide."]}]}
{"type": "biolink:MolecularActivity", "ic": "78.688704758796746", "identifiers": [{"i": "GO:0004843", "l": "cysteine-type deubiquitinase activity", "d": ["An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976768", "l": "Factor H binds to C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12715", "l": "a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+) => a nucleoside 5'-phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36880", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682020", "l": "MRN complex binds shortened telomeres (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30809", "l": "Delta(1)-piperideine-2-carboxylate + H(+) + NADH => L-pipecolate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16921", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}, {"i": "EC:2.4.1.155", "l": "\"alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51256", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2 = (9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52259", "l": "a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34424", "l": "(-)-secoisolariciresinol + NADP(+) => (+)-lariciresinol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917839", "l": "apo-Transferrin dissociates from the receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.594043123901756", "identifiers": [{"i": "GO:0071855", "l": "neuropeptide receptor binding", "d": ["Binding to a neuropeptide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33828", "l": "ergosterol => vitamin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.706056554619465", "identifiers": [{"i": "GO:0052866", "l": "phosphatidylinositol phosphate phosphatase activity", "d": ["Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097262", "l": "eoxin D4 synthase activity", "d": ["Catalysis of the reaction: eoxin C4 = eoxin D4 + 5-L-glutamyl amino acid."]}, {"i": "REACT:R-HSA-2161945", "l": "EXC4 is converted to EXD4 by GGT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47562", "l": "CMP + ganglioside GM1b (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848758", "l": "PTK6 phosphorylates AKT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51422", "l": "an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2S,3S)-flavan-3-ol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59812", "l": "hexadecanoyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28305", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + germacrene C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32530", "l": "N,N'-diacetylchitobiose + phosphate <=> N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419166", "l": "GEFs activate RhoA,B,C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56421", "l": "apo-[D-alanyl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32565", "l": "alpha-terpinene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182594", "l": "Association of INK4 family proteins with CDK4/6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51620", "l": "CTP + formate + H(+) = CO2 + dCTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375154", "l": "Interaction of NCAM1 with Major prion protein (PrP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50424", "l": "(8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43569", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) => 3,6-anhydro-L-galactonate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52122", "l": "(19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52846", "l": "1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP => 3,4-dihydroxybenzoate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375384", "l": "Bombesin-like receptors bind bombesin homologues (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71619", "l": "(S)-malate(in) + 2 thiosulfate(out) = (S)-malate(out) + 2 thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47377", "l": "(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27546", "l": "anthranilate + FADH2 + O2 = 3-hydroxyanthranilate + FAD + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.8", "l": "\"anthranilate 3-monooxygenase (FAD)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670874", "l": "FIXa variant:FVIIIa does not convert FX to the active FXa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69636", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53581", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45784", "l": "2 H2O + phenylpropanonitrile = 3-phenylpropanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050157", "l": "ornithine racemase activity", "d": ["Catalysis of the reaction: L-ornithine = D-ornithine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69217", "l": "(omega-1)-methyl-(3R)-hydroxy-fatty acyl-CoA + NADP(+) => (omega-1)-methyl-3-oxo-fatty acyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69682", "l": "apigenin 7-O-beta-D-glucoside + H2O <=> apigenin + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42228", "l": "17beta-estradiol + A = AH2 + estrone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33246", "l": "L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72997", "l": "L-fucose(in) + 2 Na(+)(in) => L-fucose(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19104", "l": "2-butyne-1,4-diol + NAD(+) <=> 4-hydroxy-2-butynal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60938", "l": "an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853745", "l": "RET binds GFRA1,GFRA3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396370", "l": "VTN binds collagens II, III and V (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0016636", "l": "oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein."]}, {"i": "EC:1.3.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667914", "l": "ALK binds ligand midkine (MDK) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850534", "l": "PDCL promotes G-protein beta 5 folding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59072", "l": "AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.308", "l": "\"cytidylyl-2-hydroxyethylphosphonate methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19120", "l": "dopamine + 2 L-ascorbate + O2 <=> (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649393", "l": "ERBB2 KD mutants bind trastuzumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380782", "l": "STAT binds to the active receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31157", "l": "(4S)-4-hydroxy-L-glutamate + H(+) + NADH => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53014", "l": "chloride + chlorohydroquinone + glutathione disulfide + H(+) => 2,5-dichlorohydroquinone + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035236", "l": "proctolin receptor activity", "d": ["Combining with the neuropeptide proctolin, to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391942", "l": "IP receptor can bind prostacyclin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647980", "l": "mature RAS proteins translocate to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54103", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36537", "l": "CoA + H(+) + N-docosanoylsphinganine => docosanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0055105", "l": "ubiquitin-protein transferase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56049", "l": "daidzein + UDP-alpha-D-glucose => daidzein 7-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9615348", "l": "AGT(34-41) binds to AGTR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72249", "l": "(R)-normetanephrine + H(+) + S-adenosyl-L-homocysteine => (R)-noradrenaline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54380", "l": "(2E,6E)-farnesyl diphosphate + H2O = 5-hydroxy-alpha-gurjunene + diphosphate", "d": []}, {"i": "EC:4.2.3.184", "l": "\"5-hydroxy-alpha-gurjunene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953398", "l": "PIR oxygenates quercetin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14360", "l": "ATP + riboflavin <=> ADP + FMN + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50779", "l": "hexanal + NADP(+) <=> (E)-hex-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28374", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11237", "l": "putrescine + spermidine => propane-1,3-diamine + sym-homospermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31726", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029268", "l": "Phosphorylation and activation of PLCG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69213", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ATP + L-glutamate => (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191654", "l": "c-src associates with Cx43 in gap junctions (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54755", "l": "methanophenazine + reduced coenzyme F420-(gamma-L-Glu)(n) <=> dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64464", "l": "L-tyrosyl-[protein] + 2 O2 = H(+) + H2O2 + L-topaquinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.414603710654305", "identifiers": [{"i": "GO:0043565", "l": "sequence-specific DNA binding", "d": ["Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190265", "l": "FGFR4 binds to FGF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17604", "l": "ATP + D-ribulose <=> ADP + D-ribulose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50508", "l": "acetyl-CoA + N-terminal L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012203", "l": "miR-26A and B bind to the 3'UTR of the CHD11 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187575", "l": "Ubiquitination of phospho-p27/p21 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9007447", "l": "E2F6 forms the PRC1L4 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69364", "l": "6-diazo-5-oxo-L-norleucine + acetyl-CoA = CoA + H(+) + N(alpha)-acetyl-6-diazo-5-oxo-L-norleucine", "d": []}, {"i": "EC:2.3.1.307", "l": "\"6-diazo-5-oxo-L-norleucine N(alpha)-acetyltranferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13136", "l": "CTP + di-trans,poly-cis-dolichol <=> a dolichyl phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62914", "l": "1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+) => H(+) + NADH + O2 + toralactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038653", "l": "RHCE gene produces Rhesus C or E proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74401", "l": "2 (S)-lactate(out) + prostaglandin F2alpha(in) => 2 (S)-lactate(in) + prostaglandin F2alpha(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010181", "l": "FMN binding", "d": ["Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69766", "l": "a medium-chain fatty aldehyde + H2O + NAD(+) <=> a medium chain fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112434", "l": "Formation of DSIF complex  (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39179", "l": "(2E)-eicosenoyl-CoA + H(+) + NADPH = eicosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39994", "l": "(4R)-hydroxyeicosasphinganine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61930", "l": "(R)-miconazole(out) + ADP + H(+) + phosphate => (R)-miconazole(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60950", "l": "(S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine => (S)-eriodictyol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34974", "l": "Fe(3+)(in) <=> Fe(3+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37632", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39579", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA = (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033760", "l": "2'-deoxymugineic-acid 2'-dioxygenase activity", "d": ["Catalysis of the reaction: 2'-deoxymugineate + 2-oxoglutarate + O2 = CO2 + H+ + mugineate + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672817", "l": "Active MTORC1 binds the ULK1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68529", "l": "(2E,6E)-farnesyl diphosphate => beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59749", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] => CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13580", "l": "a wax ester + H2O <=> a long chain fatty alcohol + a long-chain fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042654", "l": "ecdysis-triggering hormone receptor activity", "d": ["Combining with ecdysis-triggering hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604752", "l": "Initial activation of proMMP13 by MMP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51803", "l": "deoxyadlupulone + dimethylallyl diphosphate <=> adlupulone + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38655", "l": "6-tuliposide B = D-glucose + tulipalin B", "d": []}, {"i": "EC:4.2.99.23", "l": "\"tuliposide B-converting enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.9", "l": "\"phosphomannan mannosephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334099", "l": "UHRF1 binds chromatin with hemimethylated cytosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42754", "l": "H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63667", "l": "(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH <=> H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49849", "l": "(-)-dehydrodiconiferyl acid ketone + a quinone + H2O => (-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879674", "l": "CD97 binds CD55 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74974", "l": "L-leucine(out) + L-lysine(in) + Na(+)(out) <=> L-leucine(in) + L-lysine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34697", "l": "Delta(6)-protoilludene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74934", "l": "2 2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + 2 O2 <=> a (3R)-3-isocyanyl-fatty acid + 3 CO2 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33317", "l": "1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.42903515889401", "identifiers": [{"i": "GO:0016880", "l": "acid-ammonia (or amide) ligase activity", "d": ["Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672961", "l": "PP2A dephosphorylates inactive RAFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58870", "l": "4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54243", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70436", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + O2 => a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67805", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(20)-[histone H4] + O2 => CO2 + formaldehyde + L-lysyl(20)-[histone H4] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65035", "l": "3 a quinone + protoporphyrinogen IX <=> 3 a quinol + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68290", "l": "CoA + O-heptanoyl-L-seryl-[protein] => heptanoyl-CoA + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1461982", "l": "Alpha-defensin dimers multimerize to form a pore complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74940", "l": "2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + O2 => a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60289", "l": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607043", "l": "factor VIIIa associates with cell membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5140741", "l": "WNT5A binds FZD and ROR receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11849", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine => [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24217", "l": "(2E,6E)-farnesal + H2O + NAD(+) => (2E,6E)-farnesoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018583", "l": "biphenyl-2,3-diol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682992", "l": "KDM4A,B bind H4K20Me2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0016531", "l": "copper chaperone activity", "d": ["Directly binding to and delivering copper ions to a target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19143", "l": "11-cis-retinol => all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008488", "l": "gamma-glutamyl carboxylase activity", "d": ["Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018754", "l": "GDIs bind RHOH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37518", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57629", "l": "3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate => H2O + ML-236C carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821395", "l": "PAXIP1 binds PAGR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1364044", "l": "PRLR:JAK2 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701147", "l": "TRPV1 binds TRPV1 blockers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2314686", "l": "ASA- acetylates PTGS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73945", "l": "FAS-mediated dimerization of procaspase-8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22754", "l": "AH2 + barbiturate + H(+) => A + H2O + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33952", "l": "ribostamycin + UDP-N-acetyl-alpha-D-glucosamine => 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38432", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O => (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.98.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52346", "l": "(24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17883", "l": "D-glucosamine + sulfate => H2O + N-sulfo-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36876", "l": "(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14659", "l": "D-ribulose 5-phosphate => aldehydo-D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56594", "l": "a ketone + hydrogen cyanide => a disubstituted aliphatic (S)-hydroxynitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875568", "l": "RAPGEF1 activates RAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52483", "l": "16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56629", "l": "5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O => chloride + 2 H(+) + maleylacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36940", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA => (9Z)-tetradecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5333051", "l": "RPA1 binds HSF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59437", "l": "4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein] => 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432129", "l": "FGR binds and phosphorylates LRP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69201", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[tubulin] + L-glutamate => ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[tubulin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664306", "l": "LTC4 binds CyslTR1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759158", "l": "SQSTM1 oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67781", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010314", "l": "phosphatidylinositol-5-phosphate binding", "d": ["Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60307", "l": "N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549129", "l": "OCT1 transports organic cations into hepatic cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17845", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.193", "l": "\"5-amino-6-(5-phosphoribosylamino)uracil reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15455", "l": "H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12252", "l": "4-O-(beta-D-glucosyl)-trans-coniferol + H2O = (E)-coniferol + D-glucose", "d": []}, {"i": "EC:3.2.1.126", "l": "\"coniferin beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16840", "l": "5'-acylphosphoadenosine + H2O <=> a carboxylate + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71561", "l": "5-aminomethyl-dUMP in DNA + AH2 + glyoxylate => 5-N(alpha)-glycyl-dTMP in DNA + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174963", "l": "NAT1 acetylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64178", "l": "(9Z)-octadecenoate + L-tryptophan => H2O + N-(9Z-octadecenoyl)-L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011241", "l": "SRC phosphorylates ROBO3.1 in response to NTN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72623", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxy-fatty acyl)-sphingoid base = a 1,2-diacyl-sn-glycerol + inositol-1-phospho-N-(2-hydroxy-fatty acyl)-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72537", "l": "2 H(+) + NADPH + vanillate => H2O + NADP(+) + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043422", "l": "protein kinase B binding", "d": ["Binding to protein kinase B, an intracellular kinase that is important in regulating glucose metabolism."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047009", "l": "3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-androstane-17-one = NADH + H+ + 5-beta-androstane-3,17-dione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32869", "l": "myo-inositol(in) => myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35252", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(in) + ATP + H2O => ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35916", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.59", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508282", "l": "SYK is a substrate for JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391211", "l": "Trace amine-associated receptors can bind trace amines (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11694", "l": "NADH + NADP(+) => NAD(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76028", "l": "(S)-reticuline + 2-oxoglutarate + O2 => (S)-6-O-demethylreticuline + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205306", "l": "Interaction of SHP1 and KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102730", "l": "cathasterone hydroxylase activity", "d": ["Catalysis of the reaction: cathasterone + O2 + a reduced electron acceptor <=> teasterone + H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63686", "l": "(4R,5S)-dethiobiotin + ADP + H(+) + phosphate => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71048", "l": "glycine(in) + L-phenylalanine(out) => glycine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029460", "l": "PAK1 phosphorylates LIMK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3828025", "l": "DCN (decorin) degradation by MMP14 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102709", "l": "S-adenosyl-L-methionine:N,N-dimethyl-beta-alanine N-methyltransferase activity", "d": ["Catalysis of the reaction: N,N-dimethyl-beta-alanine + S-adenosyl-L-methionine = H+ + beta-alanine betaine + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74718", "l": "Internalisation of the insulin receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9760402", "l": "ILF3 binds HOXC8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392752", "l": "Phosphorylation of L1 by CK-II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27432", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 1,2-diacyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912363", "l": "MIR200B/C microRNAs bind NOTCH1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372697", "l": "Crk binding to p130cas (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016980", "l": "creatinase activity", "d": ["Catalysis of the reaction: creatine + H2O = sarcosine + urea."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001019", "l": "plastid promoter transcription regulatory region sequence-specific DNA binding", "d": ["Binding to a DNA region that controls transcription by a plastid RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.120", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265456", "l": "NPC1L1 binds ezetimibe (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14097", "l": "3-phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetate", "d": []}, {"i": "EC:2.6.1.70", "l": "\"aspartate--phenylpyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2586555", "l": "JAK2 Autophosphorylates in Response to Leptin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69320", "l": "glucoerucin + H2O = (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47798", "l": "an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin] => an aralkylamine + H2O + 2 oxidized [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74629", "l": "acetaldehyde + fumagillin + H2O + NADP(+) => NADPH + 2 O2 + prefumagillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814096", "l": "ARL1:GTP binds SCOC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15943", "l": "acetate + L-ornithine => H2O + N(2)-acetyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809254", "l": "MTMR8 binds MTMR9 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34487", "l": "dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol = alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.289", "l": "\"N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62904", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73703", "l": "UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-glucosamine(in) = UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-glucosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29237", "l": "a menaquinol + NAD(+) => a menaquinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850777", "l": "SPINK6 binds KLK14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23276", "l": "2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde", "d": []}, {"i": "EC:4.1.2.12", "l": "\"2-dehydropantoate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034282", "l": "ent-pimara-8(14),15-diene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-8(14),15-diene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53780", "l": "beta-muricholate + lithocholoyl-CoA = beta-muricholoyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654623", "l": "Activated FGFR3 binds FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60845", "l": "a 5'-end diphospho-guanosine in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160874", "l": "HYAL1 hydrolyses (HA)50 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64130", "l": "L-phenylalanine + octadecanoate => H2O + N-octadecanoyl-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58286", "l": "H(+) + NADPH + thymine => 5,6-dihydrothymine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47329", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64894", "l": "AMP + H(+) + tetradecanoyl-[ACP] => holo-[ACP] + tetradecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64702", "l": "acetophenone + H(+) + NADH => 1-phenylethanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68658", "l": "7beta-hydroxycholesterol + NADP(+) => 7-oxocholesterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172126", "l": "DAP12 interacts with NKG2C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72723", "l": "UDP-alpha-D-xylose(in) + UMP(out) = UDP-alpha-D-xylose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71968", "l": "(S)-2-hydroxyglutarate(out) + 3 Na(+)(out) => (S)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24531", "l": "(R)-lactaldehyde + NAD(+) <=> H(+) + methylglyoxal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36515", "l": "H(+) + malonyl-CoA + tetracosanoyl-CoA = 3-oxohexacosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28613", "l": "H2O + XTP <=> diphosphate + H(+) + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685318", "l": "BCDX2 complex formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605736", "l": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47649", "l": "D-ribitol 5-phosphate + H2O => phosphate + ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607721", "l": "Activation of NIK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72472", "l": "citrate(out) + D-threo-isocitrate(in) => citrate(in) + D-threo-isocitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15432", "l": "heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213195", "l": "Formation of anchoring fibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624494", "l": "RAF1 binds p21 RAS:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140701", "l": "3',3'-cyclic GMP-AMP synthase activity", "d": ["Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(3'-5') (cyclic 3',3' GAMP)."]}, {"i": "RHEA:35647", "l": "ATP + GTP = 3',3'-cGAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14825", "l": "(1R,5S)-carveol + NAD(+) = (S)-carvone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.275", "l": "\"(+)-trans-carveol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72555", "l": "estrone 3-sulfate(out) + propanoate(in) = estrone 3-sulfate(in) + propanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015105", "l": "arsenite transmembrane transporter activity", "d": ["Enables the transfer of arsenite from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708557", "l": "FBXL17 binds BACH1:MAFK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10847", "l": "oxaloacetate + pyridoxamine <=> L-aspartate + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340226", "l": "CYGB dioxygenates NO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956676", "l": "YAP1 binds TP73 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047003", "l": "dTDP-6-deoxy-L-talose 4-dehydrogenase activity", "d": ["Catalysis of the reaction: dTDP-6-deoxy-L-talose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726509", "l": "NR3C2 binds fludrocortisone (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080017", "l": "alpha-humulene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-humulene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12728", "l": "D-iditol + NAD(+) <=> H(+) + keto-D-sorbose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37136", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate => 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062101", "l": "peptidyl-aspartic acid 3-dioxygenase activity", "d": ["Catalysis of the reaction: protein L-aspartate + 2-oxoglutarate + O2 = protein 3-hydroxy-L-aspartate + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042279", "l": "nitrite reductase (cytochrome, ammonia-forming) activity", "d": ["Catalysis of the reaction: NH3 + 2 H2O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40378", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16902", "l": "acetyl-CoA + L-2,4-diaminobutanoate => (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733766", "l": "MESP1 binds the GATA4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692738", "l": "HRH2 binds HRH2 antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49031", "l": "(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24931", "l": "H2O + L-cysteine = H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.156", "l": "\"adenosylcobinamide kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662617", "l": "MT1G binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66072", "l": "4-methyl-2-oxopentanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48851", "l": "(9Z,12Z)-octadecadienoate + O2 <=> 13-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.150", "l": "\"N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31650", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614591", "l": "Excess cysteine yields lanthionine and H2S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14575", "l": "5-dehydro-4-deoxy-D-glucarate + H2O => D-glucarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67747", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) + H2O <=> 1-O-alkyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033490", "l": "Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964274", "l": "G alpha (12) binds BTK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21836", "l": "D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": []}, {"i": "EC:4.2.1.5", "l": "\"arabinonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48036", "l": "globoside Gb4Cer (d18:1(4E)) + H2O = globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102177", "l": "24-methylenelophenol methyl oxidase activity", "d": ["Catalysis of the reaction: 24-methylenelophenol + O2 + NADH + H+ <=> 4alpha-hydroxymethyl-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110360", "l": "Recruitment of POLB to the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17010", "l": "2-succinylbenzoate + ATP + CoA => 2-succinylbenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15863", "l": "3-ADP-glycerate + phosphate => 3-ADP-2-phosphoglycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.80", "l": "\"long-chain fatty acid omega-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5334827", "l": "SUMO-CRABP2 binds atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865994", "l": "GAB1 binds PTPN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54696", "l": "4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase] = 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.50", "l": "\"4-hydroxybenzoate adenylyltransferase FadD22\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51232", "l": "2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43853", "l": "H(+) + malonyl-CoA + triacontanoyl-CoA => 3-oxo-dotriacontanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24934", "l": "H2O + L-cysteine <=> H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52614", "l": "3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein] => 3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37149", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34106", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.50", "l": "\"3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051718", "l": "DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA)."]}, {"i": "REACT:R-HSA-5334151", "l": "DNMT1 methylates cytosine in hemimethylated DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70396", "l": "3-oxosphinganine + docosanoyl-CoA => CoA + H(+) + N-docosanoyl-3-ketodihydrosphingosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24408", "l": "adenosine + H(+) + H2O = inosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37761", "l": "1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9761344", "l": "USP18 binds IKBKG within IKK complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26277", "l": "Co-precorrin-4 + S-adenosyl-L-methionine = Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.271", "l": "\"cobalt-precorrin-4 methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29685", "l": "alpha-D-glucose 1-phosphate + alpha-maltopentaose => alpha-maltohexaose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74293", "l": "an alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651792", "l": "LIG1 and POLB dissociate from repaired dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694337", "l": "Trimmed spike protein binds to calnexin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989765", "l": "Expression of ABCA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029468", "l": "Conversion of PA into DAG by PAP-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656070", "l": "FGFBPs bind FGFs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749253", "l": "Formation of MCM2-7 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019215", "l": "intermediate filament binding", "d": ["Binding to an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72241", "l": "estrone 3-sulfate(in) + L-glutamate(out) => estrone 3-sulfate(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693198", "l": "RHOD binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448632", "l": "IL34 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189439", "l": "ALAD condenses 2 dALAs to form PBG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43284", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48014", "l": "2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite => 4-methyl-5-nitrocatechol + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12025", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + choline => D-glucose + O-sinapoylcholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170799", "l": "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174731", "l": "Degradation of newly synthesized ApoB-48 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37257", "l": "2-oxosuccinamate + AH2 + NH4(+) => A + D-asparagine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20488", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.12", "l": "\"dCTP diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37364", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 => 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683792", "l": "p-T68-CHEK2 autophosphorylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201639", "l": "Caspase-mediated cleavage of GAS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58465", "l": "a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844610", "l": "NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73647", "l": "CTP(out) + IMP(in) = CTP(in) + IMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31445", "l": "ADP + D-sedoheptulose 1,7-bisphosphate + H(+) => ATP + D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19441", "l": "benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75383", "l": "bromide(in) = bromide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17197", "l": "2 3-(4-hydroxyphenyl)pyruvate + O2 = 2 4-hydroxyphenylacetate + 2 CO2", "d": []}, {"i": "EC:1.2.3.13", "l": "\"4-hydroxyphenylpyruvate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60337", "l": "N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11248", "l": "[(3R)-hydroxybutanoate](n) + H2O = (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28552", "l": "CoA + N-acetylanthranilate => acetyl-CoA + anthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17804", "l": "acetyl-CoA + L-phenylalanine <=> CoA + H(+) + N-acetyl-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44095", "l": "ATP + CoA + nonadecanoate <=> AMP + diphosphate + nonadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006490", "l": "MECP2 binds the GRIN2A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30212", "l": "2 Fe(III)-[cytochrome c] + H2O + nitrous oxide => 2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49072", "l": "dibenzothiophene + 2 FMNH2 + 2 O2 = dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O", "d": []}, {"i": "EC:1.14.14.21", "l": "\"dibenzothiophene monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28727", "l": "Cu(2+)(in) + H(+)(in) = Cu(2+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168947", "l": "Ligand binds to TLR10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602885", "l": "Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676595", "l": "TRAFs bind RANK:RANKL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9727607", "l": "MME:Zn2+ binds sacubitrilat (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68609", "l": "H(+) + isatin + NADPH => 3-hydroxyindolin-2-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005141", "l": "interleukin-10 receptor binding", "d": ["Binding to an interleukin-10 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51846", "l": "(9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28929", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+) => 3,4,5-trihydroxybenzoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2468040", "l": "Cohesin binds PDS5 and WAPAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41794", "l": "CoA + malonyl-[ACP] => holo-[ACP] + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39405", "l": "(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+) => (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.8.-", "l": "\"With a flavin as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33004", "l": "(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] => (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9660557", "l": "RAS:GTP binds RAL GDS proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52638", "l": "a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate => 2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023345", "l": "NOTCH1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44013", "l": "(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) => (9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64198", "l": "a fatty acid + L-lysine => an N-(fatty acyl)-L-lysine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24980", "l": "3-hydroxy-4-methylanthranilate + ATP + H(+) = 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate", "d": []}, {"i": "EC:2.7.7.97", "l": "\"3-hydroxy-4-methylanthranilate adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15126", "l": "acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) => CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52342", "l": "AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase] => a long-chain fatty acyl-AMP + holo-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71050", "l": "Trimerization of the FASL:FAS receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51365", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine => CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.44", "l": "\"2-hydroxybiphenyl 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17403", "l": "4-carboxy-2-hydroxy-cis,cis-muconate + H2O => 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034897", "l": "4-(1-ethyl-1,4-dimethyl-pentyl)phenol monooxygenase activity", "d": ["Catalysis of the reaction: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol + O2 + 2 H+ + 2 e- = hydroquinone + 3,6-dimethylheptan-3-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72647", "l": "Cap-bound mRNA is activated by helicases  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112604", "l": "Phosphorylated STATs are released (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57506", "l": "pyruvate + succinate => 3-hydroxybutane-1,2,3-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16998", "l": "3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol => 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63366", "l": "(S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2 => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045520", "l": "interleukin-24 receptor binding", "d": ["Binding to an interleukin-24 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66396", "l": "ATP + cholate(in) + glutathione(in) + H2O = ADP + cholate(out) + glutathione(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38621", "l": "H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside => nicotinate beta-D-ribonucleotide + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419841", "l": "Light stimulates opsin receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31706", "l": "2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54688", "l": "alliin = 2-aminoprop-2-enoate + allylsulfenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44895", "l": "an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose <=> an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875451", "l": "MET phosphorylates CBL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176298", "l": "Activation of claspin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696267", "l": "RND3 binds GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32804", "l": "ATP + H2O + urea(out) => ADP + H(+) + phosphate + urea(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67597", "l": "heptadecasphing-4-enine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419645", "l": "Dimerization of LIMK1 by Hsp90 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42954", "l": "5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(49) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37321", "l": "ADP + glycyl-L-methionine(in) + H(+) + phosphate => ATP + glycyl-L-methionine(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45426", "l": "(9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.12", "l": "\"envelysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40771", "l": "(20S)-ginsenoside Rg1 + H2O = (20S)-ginsenoside F1 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375160", "l": "NCAM1 binds to ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977371", "l": "Factor I inactivates Factor H-boundC3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211224", "l": "Anthrax cya catalyzes the conversion of ATP to cAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55052", "l": "H2O + pentanoyl-CoA = CoA + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69771", "l": "a short-chain fatty aldehyde + H2O + NAD(+) = a short-chain fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928657", "l": "MMP2,9 cleave EPHB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102787", "l": "caffeoyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin 3-O-beta-D-caffeoylglucoside + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55280", "l": "13-cis-retinol + tetradecanoyl-CoA = 13-cis-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69127", "l": "Formation of the Flap Intermediate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49983", "l": "H2O + hexanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450474", "l": "MK2 phosphorylates BRF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48614", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase] => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44104", "l": "decanal + H2O + NAD(+) = decanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870466", "l": "RGGT:CHM binds RABs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73488", "l": "a carboxylate(in) + orotate(out) => a carboxylate(out) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21952", "l": "5alpha-pregnane-3,20-dione + NADP(+) = H(+) + NADPH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014812", "l": "ROBOs bind keratan sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47232", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49265", "l": "5-O-[(E)-caffeoyl]-shikimate + H2O => (E)-caffeate + H(+) + shikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69822", "l": "H(+) + hypotaurine + NADPH + O2 <=> H2O + NADP(+) + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40339", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52750", "l": "2 isomaltose => alpha-isomaltosyl-(1->3)-isomaltose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23209", "l": "acetyl-CoA + trans-glutaconate => (2E)-glutaconyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65100", "l": "a 1-acylglycerol + hexadecanoyl-CoA = an hexadecanoyl-acylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57027", "l": "apulose 4-phosphate + D-glyceraldehyde 3-phosphate <=> D-xylulose 5-phosphate + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1370500", "l": "PRLR binds SCF beta-TrCP complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-912790", "l": "CBL binds CRK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11774", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH => 6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34139", "l": "Delta(9)-tetrahydrocannabinolate + H(+) = CO2 + Delta(9)-tetrahydrocannabinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683593", "l": "ATG7:ATG3:LC3 dissociates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41529", "l": "(2E)-octenoyl-[ACP] + H(+) + NADH => NAD(+) + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.117", "l": "\"D-arabinose 1-dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727607", "l": "MME:Zn2+ binds sacubitrilat (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10954", "l": "(E)-sinapoyltartronate + CoA => (E)-sinapoyl-CoA + hydroxymalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:1901513", "l": "lipo-chitin oligosaccharide transmembrane transporter activity", "d": ["Enables the transfer of lipo-chitin oligosaccharide from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50458", "l": "prostaglandin D3 => prostaglandin H3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168638", "l": "Activated IKK phosphorylates I-kappaB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655843", "l": "Expression of Fatty Acid Synthase (FASN) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047797", "l": "cyclohexanone dehydrogenase activity", "d": ["Catalysis of the reaction: A + cyclohexanone = AH(2) + cyclohex-2-enone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2317332", "l": "PIP3 recruits AKT to the membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39531", "l": "3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57125", "l": "2-oxoglutaramate => 2-hydroxy-5-oxoproline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71789", "l": "(R)-2-hydroxyglutarate + CO2 => 2-oxoadipate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665998", "l": "MKL1 binds SRF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31006", "l": "(S)-2,3-epoxysqualene <=> germanicol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013108", "l": "GDIs block activation of RHOC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592371", "l": "Initial activation of proMMP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12275", "l": "H(+) + L-dopa <=> CO2 + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39803", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34871", "l": "methanol(out) = methanol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42290", "l": "(8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP] => 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036239", "l": "taxoid 7beta-hydroxylase activity", "d": ["Catalysis of the reaction: taxusin + [reduced NADPH-hemoprotein reductase] + O2 = 7beta-hydroxytaxusin + [oxidized NADPH-hemoprotein reductase] + H2O and 2alpha-hydroxytaxusin + [reduced NADPH-hemoprotein reductase] + O2 = 2alpha,7beta-dihydroxytaxusin + [oxidized NADPH-hemoprotein reductase] + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23200", "l": "H2O + N(6)-methyl-L-lysine + O2 = formaldehyde + H2O2 + L-lysine", "d": []}, {"i": "EC:1.5.3.4", "l": "\"N(6)-methyl-lysine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36136", "l": "(2E)-hexadecenal + H2O + NAD(+) => (E)-hexadec-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74898", "l": "nitric oxide(out) <=> nitric oxide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17396", "l": "3-maleylpyruvate <=> 3-fumarylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655823", "l": "Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357479", "l": "p-AXL binds PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45693", "l": "N-(octanoyl)-sphing-4-enine-1-phosphate(in) => N-(octanoyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42592", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41575", "l": "lipoxin A4 + NAD(+) <=> 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932322", "l": "CK2 phosphorylates NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29041", "l": "ADP + H(+) + L-aspartate(in) + phosphate => ATP + H2O + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577244", "l": "MSH2 variant:MSH6-defective DNA mismatch repair (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13061", "l": "O2 + S-sulfanylglutathione = glutathione S,S-dioxide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42449", "l": "(R)-2-hydroxyglutaryl-CoA => (2E)-glutaconyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65273", "l": "chrodrimanin C + H(+) + NADPH + O2 => chrodrimanin H + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46675", "l": "aldosterone + H(+) + NADPH <=> 5beta-dihydroaldosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0015114", "l": "phosphate ion transmembrane transporter activity", "d": ["Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other."]}, {"i": "RHEA:32823", "l": "phosphate(in) = phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935730", "l": "RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17627", "l": "H(+) + L-lysine + NADPH + pyruvate => D-lysopine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801776", "l": "REG3A binds bacterial phospholipids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26474", "l": "beta-D-galactosyl-(1->4)-L-rhamnose + phosphate = alpha-D-galactose 1-phosphate + L-rhamnopyranose", "d": []}, {"i": "EC:2.4.1.247", "l": "\"beta-D-galactosyl-(1->4)-L-rhamnose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388808", "l": "CD28 homodimer binds B7-2 monomer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-176956", "l": "Formation of GINS complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62648", "l": "(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50558", "l": "H2O + prostaglandin J2 => prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63123", "l": "(11Z)-eicosenamide + H2O <=> (11Z)-eicosenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16895", "l": "N-methylpyridinium + S-adenosyl-L-homocysteine => pyridine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084910", "l": "Collagen type II binds integrin alpha2beta1, alpha1beta1, alpha11beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9817575", "l": "ERO1B oxidizes P4HB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38437", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73807", "l": "GDP + S-adenosyl-L-methionine = N(7)-methyl-GDP + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.968459345787338", "identifiers": [{"i": "GO:0016661", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}, {"i": "EC:1.7.-.-", "l": "\"Acting on other nitrogenous compounds as donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62316", "l": "salicylate + UDP-alpha-D-glucose = 1-O-salicyl-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39798", "l": "7beta-hydroxycholesterol(in) + ATP + H2O <=> 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43682", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23716", "l": "(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23430", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58698", "l": "H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide => NADPH + O2 + rifampicin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74299", "l": "D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50024", "l": "dodecanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32273", "l": "4-methyl-2-oxopentanoate + CO2 + NADH => (2R,3S)-3-isopropylmalate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20559", "l": "CO2 + 2 NH4(+) => 2 H(+) + H2O + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061751", "l": "neutral sphingomyelin phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+ in a neutral environment."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68997", "l": "2-oxoglutarate + gibberellin A9 + O2 => CO2 + gibberellin A4 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46405", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50715", "l": "chloride + FADH2 + O2 + tetracycline <=> 7-chlorotetracycline + FAD + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32345", "l": "(+)-thujan-3-one + H(+) + NADH => (+)-thujan-3-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58895", "l": "3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9 <=> adenosine 3',5'-bisphosphate + H(+) + omega-sulfo-beta-dihydromenaquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66875", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15989", "l": "(R)-mevalonate + CoA + 2 NADP(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH", "d": []}, {"i": "EC:1.1.1.34", "l": "\"hydroxymethylglutaryl-CoA reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944216", "l": "Association of procollagen type XV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10840", "l": "H2O + O-phospho-L-homoserine = L-threonine + phosphate", "d": []}, {"i": "EC:4.2.3.1", "l": "\"threonine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14885", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] = ADP-D-ribose + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11463", "l": "ADP + D-glucose <=> AMP + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16623", "l": "H2O2 + sanguinarine => dihydrosanguinarine + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40077", "l": "futalosine + NH4(+) => 6-amino-6-deoxyfutalosine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59385", "l": "2-oxoglutarate + 4-amino-L-phenylalanine => 3-(4-aminophenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5140741", "l": "WNT5A binds FZD and ROR receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41166", "l": "1-O-hexadecyl-2-amino-sn-glycerol + ATP <=> 1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-398184", "l": "LARG activation by G alpha 12/13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0120284", "l": "tryptophan binding", "d": ["Binding to 2-amino-3-(1H-indol-3-yl)propanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40238", "l": "coenzyme B + coenzyme M + fumarate <=> coenzyme M-coenzyme B heterodisulfide + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419334", "l": "Melatonin receptors can bind melatonin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8963851", "l": "VD3 dissociates from GC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73428", "l": "genkwanin + O2 + reduced [NADPH--hemoprotein reductase] => H2O + oxidized [NADPH--hemoprotein reductase] + scutellarein 7-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33972", "l": "5''-phosphoribostamycin + H2O => phosphate + ribostamycin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019153", "l": "protein-disulfide reductase (glutathione) activity", "d": ["Catalysis of the reaction: 2 glutathione + protein-disulfide = glutathione disulfide+ protein-dithiol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018812", "l": "3-hydroxyacyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O. The stereospecifity of the hydroxyacyl in this reaction is not specified."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45123", "l": "(4R)-ipsdienol + NAD(+) <=> H(+) + ipsdienone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73564", "l": "dGDP(out) + UTP(in) => dGDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62212", "l": "3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase] = gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110360", "l": "Recruitment of POLB to the AP site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0019158", "l": "mannokinase activity", "d": ["Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42309", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17179", "l": "CoA + O-octanoyl-(R)-carnitine => (R)-carnitine + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139893", "l": "Granzyme-B activates BID by cleavage (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65064", "l": "dimethylallyl diphosphate + siccayne = diphosphate + pestalodiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47932", "l": "(2S)-3-sulfolactaldehyde + H2O + NAD(+) = (2S)-3-sulfolactate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029454", "l": "Autophosphorylation of PAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10396", "l": "an L-alpha-amino acid + H2O + NAD(+) = a 2-oxocarboxylate + H(+) + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.5", "l": "\"L-amino-acid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.48", "l": "\"staphopain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46549", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391942", "l": "IP receptor can bind prostacyclin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944240", "l": "Association of procollagen type III (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21601", "l": "anthranilate + benzoyl-CoA => CoA + N-benzoylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75343", "l": "adenosine(in) = adenosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19420", "l": "[phosphate](n) + a dolichyl diphosphate <=> [phosphate](n+1) + a dolichyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225951", "l": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437243", "l": "Doublecortin binds phosphorylated neurofascin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103005", "l": "9,10-epoxystearate hydrolase activity", "d": ["Catalysis of the reaction: 9,10-epoxystearate + H2O <=> (9R,10S)-dihydroxystearate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18440", "l": "4-CDP-2-C-methyl-D-erythritol + ATP <=> 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382553", "l": "ABCA7:Apo1A-mediated phospholipid efflux (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54873", "l": "(1S,4R)-menthone + H(+) + NADPH + O2 => (4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392530", "l": "p-S400-Cot phosphorylates NIK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6795290", "l": "TORC2 complex phosphorylates SGK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725315", "l": "ALK-stimulated MYCN gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18089", "l": "H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+)", "d": []}, {"i": "EC:3.5.3.15", "l": "\"protein-arginine deiminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18232", "l": "glycolate + NAD(+) <=> glyoxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12755", "l": "dihydroxyacetone + H(+) + NADPH => glycerol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59503", "l": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655290", "l": "Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.55", "l": "\"non-reducing end alpha-L-arabinofuranosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560498", "l": "Expression of Lipoprotein lipase (LPL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59241", "l": "L-arginine + L-lysine => L-homoarginine + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32215", "l": "(6R)-NADHX = (6S)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35420", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60678", "l": "(S)-(-)-citronellal + H(+) + NADH => (S)-(-)-citronellol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102672", "l": "fatty acid alpha-oxygenase activity", "d": ["Catalysis of the reaction: O2 + a 2,3,4-saturated fatty acid <=> a 2(R)-hydroperoxy fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64480", "l": "4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate = (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23310", "l": "2-O-[(E)-sinapoyl]-D-glucarate + CoA => (E)-sinapoyl-CoA + D-glucarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46460", "l": "(22R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28572", "l": "diphosphate + L-seryl-5'-AMP => ATP + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10756", "l": "ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694428", "l": "LMAN family proteins bind glycosylated cargo (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169847", "l": "Assembly of NA tetramers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665700", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004239", "l": "initiator methionyl aminopeptidase activity", "d": ["Catalysis of the release of N-terminal initiator methionine from peptides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373746", "l": "SEMA4D interacts with CD45 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74498", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B <=> yaequinolone C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38504", "l": "1,3-diacyl-sn-glycerol + H2O => a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0001046", "l": "core promoter sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75415", "l": "H2O + N-methylmyosmine = pseudooxynicotine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24973", "l": "calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734353", "l": "GATA4, SMAD1:SMAD4, MEF2C, TBX20, and NKX2-5 bind the NKX2-5 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32161", "l": "A + H2O + queuosine(34) in tRNA => AH2 + epoxyqueuosine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193646", "l": "NGF binding to p75NTR inactivates RHOA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45811", "l": "galactarate <=> (2S,3R)-dihydroxy-5-oxohexanedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088134", "l": "PLK1 phosphorylates FOXM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23094", "l": "ethylamine + N-isopropylammelide => H(+) + H2O + hydroxyatrazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382056", "l": "Crk binds to the active PDGF receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046554", "l": "malate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20200", "l": "[heparosan-N-sulfate](n) <=> [heparan-N-sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13947", "l": "(R)-mandelate => (S)-mandelate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086020", "l": "gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from an SA node cell to an atrial cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098821", "l": "BMP receptor activity", "d": ["Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.71", "l": "\"glucan endo-1,2-beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853801", "l": "PSPN binds RET:GFRA4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22861", "l": "ATP + H(+) + nicotinate beta-D-ribonucleotide => deamido-NAD(+) + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878654", "l": "ACP6 hydrolyses MYS-LPA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21569", "l": "beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.4.1", "l": "\"ribonucleoside-diphosphate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20888", "l": "3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.4", "l": "\"3-hydroxyisobutyryl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37699", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936380", "l": "Interaction of PIN1 with p-IRF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043748", "l": "O-succinylbenzoate synthase activity", "d": ["Catalysis of the reaction: 2-succinylbenzoate + H2O = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate."]}, {"i": "RHEA:10196", "l": "(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O", "d": []}, {"i": "EC:4.2.1.113", "l": "\"o-succinylbenzoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45821", "l": "mesaconate + succinyl-CoA => 2-methylfumaryl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40254", "l": "4-O-methylrhodomycin D + H2O <=> 10-carboxy-13-deoxydaunorubicin + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15484", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51515", "l": "H2O + oxamate <=> NH4(+) + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720497", "l": "Defective ALG12 does not add mannose to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73341", "l": "beta-alanyl-5'-AMP + diphosphate => ATP + beta-alanine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74288", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA => an acyl-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54677", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (+)-kolavenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9620103", "l": "ALDH2 transforms GTN to NO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.938386572175233", "identifiers": [{"i": "GO:0019887", "l": "protein kinase regulator activity", "d": ["Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65175", "l": "(3Z,5E)-dodecadienoyl-CoA + H2O <=> (3Z,5E)-dodecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683606", "l": "Nucleoprotein translocates to the nucleolus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53294", "l": "H(+) + N-carbamoyl-L-methionine => H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23295", "l": "ATP + L-lombricine <=> ADP + H(+) + N-phospho-L-lombricine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32206", "l": "(R)-synephrine <=> (4-hydroxyphenyl)acetaldehyde + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004587", "l": "ornithine-oxo-acid transaminase activity", "d": ["Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23978", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate => a 3'-end 3'-phospho-ribonucleotide-RNA + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928620", "l": "PAK1 autophosphorylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18525", "l": "3-methylbutanol + NADP(+) = 3-methylbutanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.31.-", "l": "\"Endoribonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54542", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein] => H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170015", "l": "carbon dioxide receptor activity", "d": ["Combining with carbon dioxide to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19981", "l": "NADP(+) + S-(hydroxymethyl)glutathione = H(+) + NADPH + S-formylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23343", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate <=> D-arabinose + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18655", "l": "3-oxo-3-ureidopropanoate => barbiturate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14209", "l": "alpha-D-galactose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-galactose", "d": []}, {"i": "EC:2.7.7.10", "l": "\"UTP--hexose-1-phosphate uridylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13604", "l": "cis-4-hydroxy-L-proline + NAD(+) <=> 4-oxo-L-proline + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67469", "l": "H2O + malonyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44215", "l": "3-hydroxytetradecanoate + ATP + CoA <=> 3-hydroxytetradecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666425", "l": "p-6Y-SYK phosphorylates VAV1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641147", "l": "DACT1 binds DVL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61350", "l": "ADP + estrone 3-sulfate(out) + H(+) + phosphate => ATP + estrone 3-sulfate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31476", "l": "soyasapogenol B + UDP-alpha-D-glucuronate => H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678854", "l": "S1PR1 binds S1PR1 agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34348", "l": "(2E)-geraniol + NAD(+) => (2E)-geranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604722", "l": "Activation of proMMP9 by proteases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74816", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49619", "l": "2-hydroxy-2-methylpropanal + H2O + NAD(+) <=> 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466822", "l": "Defective OPN1LW causes BCM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15198", "l": "a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine => an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49291", "l": "(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.65", "l": "\"(d)CTP diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55692", "l": "an inositol-1-phosphoceramide + H2O = 1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56576", "l": "globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine = globoside Gb4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25754", "l": "N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18522", "l": "licodione + S-adenosyl-L-methionine => 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19795", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein] => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218822", "l": "CRK binds BCAR1 and or PXN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005146", "l": "leukemia inhibitory factor receptor binding", "d": ["Binding to an leukemia inhibitory factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20446", "l": "L-arogenate + oxaloacetate => L-aspartate + prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22503", "l": "(E)-feruloyl-CoA + H(+) + malonyl-CoA <=> (E)-feruloylacetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977605", "l": "Factor H displaces Bb (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664646", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 bind PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67357", "l": "(2S)-naringenin 7-O-beta-D-glucoside + malonyl-CoA => (2S)-naringenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22799", "l": "ATP + D-hamamelose <=> ADP + D-hamamelose 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20384", "l": "androsterone + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53424", "l": "a fatty acyl-CoA + a sphingoid base = an N-acyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64276", "l": "chrysophanol-9-anthrone + O2 = chrysophanol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388468", "l": "AVP(20-28) binds AVPR1A,B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48574", "l": "(2E,4E)-2,4-dichloromuconate + 2 H(+) => 3,5-dichlorocatechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54974", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP] => 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55934", "l": "AMP + H(+) + L-threonyl-[protein] => 3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30497", "l": "H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018803", "l": "4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity", "d": ["Catalysis of the reaction: (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate = 2-carboxybenzaldehyde + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63670", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH => CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26225", "l": "abieta-7,13-dien-18-al + H2O + NAD(+) = abieta-7,13-dien-18-oate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.74", "l": "\"abieta-7,13-dien-18-al dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686709", "l": "Uncoating of SARS-CoV-1 Genome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31367", "l": "2 H(+) + 3 nitrite = H2O + nitrate + 2 nitric oxide", "d": []}, {"i": "EC:1.7.6.1", "l": "\"nitrite dismutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31128", "l": "3-O-methylgallate + O2 => 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664879", "l": "ATM:PEX5 binds ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8934742", "l": "RUNX1 binds PRMT1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047612", "l": "acid-CoA ligase (GDP-forming) activity", "d": ["Catalysis of the reaction: a carboxylate + CoA + GTP = acyl-CoA + GDP + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784204", "l": "JAKs bind OSMR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34129", "l": "cannabigerolate + diphosphate => (2E)-geranyl diphosphate + olivetolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57291", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O <=> a guanosine in RNA + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19392", "l": "(E)-ferulate + ATP + CoA <=> (E)-feruloyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938121", "l": "SERPINB13 binds CTSK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13756", "l": "2 L-glutamate + NAD(+) <=> 2-oxoglutarate + H(+) + L-glutamine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102109", "l": "tricaffeoyl spermidine O-methyltransferase activity", "d": ["Catalysis of the reaction: tricaffeoyl spermidine + 3 S-adenosyl-L-methionine <=> 3 H+ + triferuloyl spermidine + 3 S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106437", "l": "protein-glutamic acid ligase activity, initiating", "d": ["Catalytic reaction: ATP + L-glutamate + L-glutamyl-[protein] = ADP + H(+) + L-gamma-glutamyl-L-glutamyl-[protein] + phosphate."]}, {"i": "RHEA:60144", "l": "ATP + L-glutamate + L-glutamyl-[protein] = ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3828025", "l": "DCN (decorin) degradation by MMP14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26553", "l": "(S)-piperazine-2-carboxamide + H2O <=> (S)-piperazine-2-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0016494", "l": "C-X-C chemokine receptor activity", "d": ["Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047495", "l": "membrane-oligosaccharide glycerophosphotransferase activity", "d": ["Catalysis of the transfer of a glycerophospho group from one membrane-derived oligosaccharide to another."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951676", "l": "RUNX3 binds TEADs and YAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35819", "l": "5,6,7,8-tetrahydromethanopterin + NADP(+) = 7,8-dihydromethanopterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983150", "l": "Proteasomal cleavage of substrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37080", "l": "2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29214", "l": "H(+)(out) + inosine(in) <=> H(+)(in) + inosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616367", "l": "NAB2 binds EGR1 to repress CDK5R1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17313", "l": "ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)", "d": []}, {"i": "EC:6.1.1.21", "l": "\"histidine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604732", "l": "Autocatalytic activation of proMMP13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102566", "l": "1-acyl dihydroxyacetone phosphate reductase activity", "d": ["Catalysis of the reaction: 1-oleoylglycerone 3-phosphate + NADPH + H+ = 1-oleoyl-sn-glycero-3-phosphate + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61710", "l": "AMP + L-seryl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-seryl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102089", "l": "dehydroscoulerine synthase activity", "d": ["Catalysis of the reaction: (S)-scoulerine + O2 = dehydroscoulerine + hydrogen peroxide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22488", "l": "S-(hydroxymethyl)glutathione = formaldehyde + glutathione", "d": []}, {"i": "EC:4.4.1.22", "l": "\"S-(hydroxymethyl)glutathione synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35648", "l": "ATP + GTP => 3',3'-cGAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68872", "l": "(E)-cinnamate + ATP + H(+) + NADPH = (E)-cinnamaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805061", "l": "CK2 binds FACT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32418", "l": "(1S,2S,4R)-isodihydrocarveol + NAD(+) <=> (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38575", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67386", "l": "5beta-cholestane-3alpha,7alpha,25-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680348", "l": "PIK3R1:PIK3CA,B,G (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19549", "l": "H2O + o-orsellinate depside = H(+) + 2 orsellinate", "d": []}, {"i": "EC:3.1.1.40", "l": "\"orsellinate-depside hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15161", "l": "4-hydroxyphenylacetate + H(+) + NADH + O2 = H2O + homogentisate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983422", "l": "Disassembly of COPII coated vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399952", "l": "Phosphorylation of LIMK-1 by PAK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25750", "l": "L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37872", "l": "2-heptyl-4(1H)-quinolone + H(+) + NADH + O2 => 2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61485", "l": "a cytidine in rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47196", "l": "a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24450", "l": "monoglucosyl-enterobactin + UDP => enterobactin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27360", "l": "iodide + S-adenosyl-L-methionine <=> iodomethane + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42966", "l": "pseudouridine(54/55) in tRNA => uridine(54/55) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46013", "l": "(S)-malate + a quinone => a quinol + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72481", "l": "citrate(in) + trans-aconitate(out) => citrate(out) + trans-aconitate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168813", "l": "SOCS binding to JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610732", "l": "GSK3 phosphorylates p-GLI3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47432", "l": "(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350058", "l": "Formation of CSL NCOR corepressor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028598", "l": "Phosphorylation of YAP by LATS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917730", "l": "Cargo Recognition And Sorting (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3321805", "l": "NSL acetylates histone H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19698", "l": "11-cis-retinyl hexadecanoate + H2O => 11-cis-retinol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689649", "l": "BAP1 binds BRCA1:BARD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195378", "l": "Homodimerization of VEGF proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41449", "l": "2-oxoglutarate + L-isoleucine + O2 => (4S)-4-hydroxy-L-isoleucine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426032", "l": "DAG is metabolized by DAGL to 2-AG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63855", "l": "dodecanoate + O2 <=> (2R)-2-hydroperoxydodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015633", "l": "ABC-type zinc transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10974", "l": "alpha-D-hexose 1-phosphate + NH4(+) => D-hexose + H(+) + phosphoramidate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13548", "l": "(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73318", "l": "1D-chiro-inositol(out) + 2 Na(+)(out) <=> 1D-chiro-inositol(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784765", "l": "p-Y705-STAT3 dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68605", "l": "(2S)-3-sulfopropanediol => H(+) + hydroxyacetone + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39140", "l": "(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35425", "l": "an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP => an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015243", "l": "cycloheximide transmembrane transporter activity", "d": ["Enables the transfer of cycloheximide from one side of a membrane to the other. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432436", "l": "CLK:CYC heterodimer binds to per, tim, vri, and Pdp1 genes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44249", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74726", "l": "isorhamnetin + S-adenosyl-L-methionine <=> 3',4'-O-dimethylquercetin + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12766", "l": "CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate => acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9716947", "l": "ESR1 binds ESR1 agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.166", "l": "\"3-deoxy-D-manno-octulosonic acid kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70247", "l": "N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose = beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50202", "l": "(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662620", "l": "MT3 binds cadmium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692297", "l": "DMRT1 binds the WNT4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.10", "l": "\"acrosin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10658", "l": "creatine + H(+) + S-adenosyl-L-homocysteine => guanidinoacetate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0016433", "l": "rRNA (adenine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229132", "l": "AP4 binds APP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-976768", "l": "Factor H binds to C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13398", "l": "6-oxohexanoate + H2O + NADP(+) => 2 H(+) + hexanedioate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54400", "l": "1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34524", "l": "[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose => [alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102299", "l": "linolenate 9R-lipoxygenase activity", "d": ["Catalysis of the reaction: alpha-linolenate + O2 <=> (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43715", "l": "ATP + dodecanoate + H(+) <=> diphosphate + dodecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57801", "l": "2,3-dinitrotoluene + NADH + O2 => 4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807826", "l": "LDHAL6B reduces PYR to LACT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74123", "l": "pelargonidin + UDP-alpha-D-galactose = pelargonidin 3-O-beta-D-galactoside betaine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33021", "l": "(3S)-6-acetamido-3-aminohexanoate + CoA + H(+) => (3S)-3,6-diaminohexanoate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197690", "l": "Detachment of WASP/WAVE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391158", "l": "SIRP alpha binds CD47 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9716947", "l": "ESR1 binds ESR1 agonists (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68371", "l": "3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose <=> 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229132", "l": "AP4 binds APP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052730", "l": "sarcosine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50279", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52097", "l": "9-octadecanoyloxy-octadecanoate + H2O => 9-hydroxy-octadecanoate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71453", "l": "bradykinin(1-7) + L-Phe-L-Arg => bradykinin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351876", "l": "Caspase-mediated cleavage of occludin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029454", "l": "Autophosphorylation of PAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019828", "l": "aspartic-type endopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of aspartic-type endopeptidases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380311", "l": "Recruitment of Plk1 to centrosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380508", "l": "Translocation of NuMA to the centrosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25338", "l": "H(+) + urea = isocyanate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74605", "l": "CMP(in) + UDP-alpha-D-galactose(out) => CMP(out) + UDP-alpha-D-galactose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70016", "l": "O2 + reduced [NADPH--hemoprotein reductase] + teasterone => 7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31686", "l": "prosolanapyrone III <=> (-)-solanapyrone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30988", "l": "(S)-2,3-epoxysqualene => (17Z)-protosta-17(20),24-dien-3beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72794", "l": "bilirubin-glucuronoside(out) <=> bilirubin-glucuronoside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57995", "l": "(20S)-ginsenoside C-K + UDP-alpha-D-glucose <=> (20S)-ginsenoside F2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39972", "l": "1-aminocyclopropane-1-carboxylate => 2-aminobut-2-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13057", "l": "an N-acylneuraminate 9-phosphate + H2O = an N-acylneuraminate + phosphate", "d": []}, {"i": "EC:3.1.3.29", "l": "\"N-acylneuraminate-9-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55166", "l": "H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+) => a jasmonyl-L-isoleucinate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950634", "l": "Expression of capping actin protein of muscle Z-line alpha subunit 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.194", "l": "\"coniferyl-alcohol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56550", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10158", "l": "12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2317332", "l": "PIP3 recruits AKT to the membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37930", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65395", "l": "4 H(+) + L-pipecolate + malonyl-CoA + 2 NADPH <=> (8aS)-octahydroindolizin-1-one + CO2 + CoA + 2 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25738", "l": "L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0051911", "l": "Methanosarcina-phenazine hydrogenase activity", "d": ["Catalysis of the reaction: H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804383", "l": "PRMT5 methylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749647", "l": "CES2 hydrolyzes ASA- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55836", "l": "calcitriol + UDP-alpha-D-glucuronate = calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700149", "l": "Active ALK binds PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55274", "l": "11-cis-retinyl tetradecanoate + CoA => 11-cis-retinol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018794", "l": "RHOV binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23940", "l": "D-gluconate + NAD(+) = 5-dehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1006169", "l": "Factor H binds host cell surface markers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12657", "l": "a (2S)-2-methylacyl-CoA = a (2R)-2-methylacyl-CoA", "d": []}, {"i": "EC:5.1.99.4", "l": "\"alpha-methylacyl-CoA racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433845", "l": "chicken RIP1 facilitates IKKs complex activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35623", "l": "D-glutamate + D-glutamine = gamma-D-glutamyl-D-glutamate + NH4(+)", "d": []}, {"i": "EC:2.3.2.1", "l": "\"D-glutamyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0050738", "l": "fructosyltransferase activity", "d": ["Catalysis of the transfer of a fructosyl group to an acceptor molecule, typically another carbohydrate or a lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5606996", "l": "Soluble PROCR binds activated protein C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36819", "l": "(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69463", "l": "[thioredoxin]-dithiol + arsenic triglutathione + 2 H2O + S-adenosyl-L-methionine <=> [thioredoxin]-disulfide + 3 glutathione + H(+) + methylarsonous acid + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428510", "l": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806831", "l": "CYB5Rs reduce MetHb to HbA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73877", "l": "(R)-adrenaline(in) => (R)-adrenaline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35369", "l": "isoheptadecanoyl-coA + NADP(+) => (2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9724685", "l": "IgE binds omalizumab (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55685", "l": "chorismate + NH4(+) => 4-amino-4-deoxychorismate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102398", "l": "dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose <=> S-adenosyl-L-homocysteine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013004", "l": "RHOA binds effectors at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75259", "l": "isoorientin + O2 = 3'-dehydroisoorientin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29527", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}, {"i": "EC:2.4.1.258", "l": "\"dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35512", "l": "glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] => glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010303", "l": "limit dextrinase activity", "d": ["Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55886", "l": "[aequorin]--dioxetanone => [aequorin] + 3 Ca(2+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42958", "l": "5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(38) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727819", "l": "TAK1 phosphorylates MKK6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013693", "l": "NICD4 binds RBPJ and MAML in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111915", "l": "CAMK4 autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69962", "l": "6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37944", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444433", "l": "Cho transports from the extracellular space to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12872", "l": "(2E)-geranyl diphosphate <=> (4S)-limonene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44416", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865626", "l": "p-STAT5 dimers bind the BRWD1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67107", "l": "2-oxoglutarate + fumigatonoid C + O2 <=> CO2 + H2O + novofumigatonin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56999", "l": "aldehydo-D-apiose <=> apulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44963", "l": "(2E)-decenoyl-CoA + H(+) + NADPH <=> decanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74178", "l": "a secondary alkyl amine + H2O + NAD(+) <=> a ketone + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102750", "l": "tetrahydrogeranylgeranyl-chlorophyll a reductase activity", "d": ["Catalysis of the reaction: chlorophyll a + NADP = tetrahydrogeranylgeranyl-chlorophyll a + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57292", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O = a guanosine in RNA + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205136", "l": "GTP-bound RAC contributes to JNK activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8856945", "l": "PP2A methylation by LCMT1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13354", "l": "4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55672", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}, {"i": "EC:2.4.1.355", "l": "\"poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797810", "l": "PTPRD binds IL1RAPL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9681375", "l": "KIT binds ripretinib (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64322", "l": "cholesteryl (9Z)-hexadecenoate + CoA => (9Z)-hexadecenoyl-CoA + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429441", "l": "SYK activation by SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191971", "l": "THCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791130", "l": "Expression of CTDSP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62605", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53868", "l": "2 H(+) + NADH + O2 + phenazine-1-carboxylate = 1-hydroxyphenazine + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560491", "l": "Expression of CEBPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015319", "l": "sodium:inorganic phosphate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + inorganic phosphate(out) = Na+(in) + inorganic phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19105", "l": "4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.19", "l": "\"aminobutyraldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.173", "l": "\"rhamnogalacturonan galacturonohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27440", "l": "2 glutathione amide + H2O2 <=> glutathione amide disulfide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56562", "l": "[1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP => [1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2247511", "l": "STAB2:ligand is endocytosed (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050093", "l": "methanol dehydrogenase activity", "d": ["Catalysis of the reaction: methanol + NAD+ = formaldehyde + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39087", "l": "decanedioyl-CoA + O2 = (2E)-decenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32603", "l": "(6E)-8-hydroxygeraniol + NADP(+) = (6E)-8-oxogeraniol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60705", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37960", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70279", "l": "H2O + stachyose = D-galactose + raffinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69068", "l": "RFC dissociates after sliding clamp formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11721", "l": "ATP + 2 H2O + N-methylhydantoin => ADP + 2 H(+) + N-carbamoylsarcosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32113", "l": "3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trans-resveratrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65252", "l": "(2E,6E)-farnesyl diphosphate + 6-hydroxymellein = diphosphate + verruculide C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685605", "l": "SLAMF7 binds SLAMF7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28618", "l": "2-methylbutyronitrile + H(+) + NADPH + O2 = 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65982", "l": "tachysterol 3 => hnu + previtamin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983138", "l": "Transport of MHC heterotrimer to ER exit site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197698", "l": "Src phosphorylate WASP,N-WASP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34197", "l": "2 aureusidin 6-O-beta-glucoside + 2 H2O => 2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67323", "l": "(2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate <=> sch 210971", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63916", "l": "5-fluorouridine + ATP = 5-fluorouridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42177", "l": "(9Z)-tetradecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-tetradecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052599", "l": "methylputrescine oxidase activity", "d": ["Catalysis of the reaction: N-methylputrescine + H2O + O2 = N-methylaminobutanal + NH3 + hydrogen peroxide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627350", "l": "SMAC (DIABLO) binds XIAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1912357", "l": "ITCH ubiquitinates DTX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1307803", "l": "TIMM22 inserts proteins into inner membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63001", "l": "(11Z,14Z,17Z)-eicosatrienamide + H2O => (11Z,14Z,17Z)-eicosatrienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39429", "l": "(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+) => (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173631", "l": "Activation of C1s (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62576", "l": "ATP + H2O + L-cystine(out) = ADP + H(+) + L-cystine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52378", "l": "(+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.45", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004776", "l": "succinate-CoA ligase (GDP-forming) activity", "d": ["Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47364", "l": "a dodecanoate ester + H2O = an aliphatic alcohol + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213207", "l": "Formation of collagen networks (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73729", "l": "Formation of SL1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59538", "l": "(2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate => ATP + butanoyl-CoA + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.3.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39447", "l": "(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63384", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044667", "l": "(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (R)-carnitine(out) + 4-(trimethylammonio)butanoate(in) = (R)-carnitine(in) + 4-(trimethylammonio)butanoate(out)."]}, {"i": "RHEA:29427", "l": "(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) = (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187382", "l": "Degradation of ubiquitinated SMAD3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450494", "l": "HuR binds mRNAs in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22438", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354097", "l": "Activation of Talin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23400", "l": "7,8-dihydroxykynurenate + O2 = 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)", "d": []}, {"i": "EC:1.13.11.10", "l": "\"7,8-dihydroxykynurenate 8,8a-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37797", "l": "2 H2O + 2 NADP(+) => 2 H(+) + 2 NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.22.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47647", "l": "adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47948", "l": "H2O + thiamine phosphate = phosphate + thiamine", "d": []}, {"i": "EC:3.1.3.100", "l": "\"thiamine phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49315", "l": "2-trans,4-trans-xanthoxin + NAD(+) <=> 2-trans-(+)-abscisic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77077", "l": "Capping complex formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018461", "l": "fluoren-9-ol dehydrogenase activity", "d": ["Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809309", "l": "MTMR6 binds MTMR9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27315", "l": "dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 => 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209133", "l": "Formation of the 'destruction complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30901", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP => bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.-", "l": "\"Other carbon-oxygen lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855077", "l": "Ficolin-3 binds to molecular patterns on the target cell surface  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72671", "l": "eIF5B:GTP is hydrolyzed and released (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373748", "l": "SEMA4D interacts with CD72 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655339", "l": "Activated FGFR2 mutants bind FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27401", "l": "2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate", "d": []}, {"i": "EC:5.99.1.4", "l": "\"2-hydroxychromene-2-carboxylate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350391", "l": "RHO1:GTP binds to activated DAAM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.-", "l": "\"Transferring other glycosyl groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902557", "l": "5'-adenylyl sulfate transmembrane transporter activity", "d": ["Enables the transfer of 5'-adenylyl sulfate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43848", "l": "[thioredoxin]-dithiol + arsenate + H(+) = [thioredoxin]-disulfide + arsenite + H2O", "d": []}, {"i": "EC:1.20.4.4", "l": "\"arsenate reductase (thioredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004949", "l": "cannabinoid receptor activity", "d": ["Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782138", "l": "ERCC5 and RPA bind TC-NER site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46081", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADH => NAD(+) + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39284", "l": "a long-chain fatty acid(out) => a long-chain fatty acid(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45115", "l": "gamma-tocopherol + H(+) + NADPH + O2 <=> 13-hydroxy-gamma-tocopherol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214398", "l": "Activated Phospho IRD5:KEY dimer phosphorylates REL in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59816", "l": "a long-chain fatty acyl-CoA + a sterol = a sterol ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73802", "l": "dimethylallyl diphosphate + isoechinulin A <=> dehydroechinulin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74158", "l": "H2O + oxidized 2[4Fe-4S]-[ferredoxin] + sarcosine <=> formaldehyde + glycine + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0070991", "l": "medium-chain-acyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106059", "l": "tRNA (cytidine 56-2'-O)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + cytidine56 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48357", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16446", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone => daidzein + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75323", "l": "chloride(out) + D-leucine(out) + 2 Na(+)(out) = chloride(in) + D-leucine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71547", "l": "5-phosphomethyl-dUMP in DNA + glycine = 5-N(alpha)-glycyl-dTMP in DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44636", "l": "2,4-dinitroanisole + H2O = 2,4-dinitrophenol + H(+) + methanol", "d": []}, {"i": "EC:3.3.2.14", "l": "\"2,4-dinitroanisole O-demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64289", "l": "2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase] => cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162191", "l": "DMPhOH is hydroxylated to MDMQ10H2 by DMPhOH monooxygenase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29400", "l": "H2O + ITP => diphosphate + H(+) + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798474", "l": "S100A8:S100A9 binds Zn2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023178", "l": "PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89)) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29401", "l": "diphosphate + H(+) + IMP => H2O + ITP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62162", "l": "N-(9Z-octadecenoyl) ethanolamine + phosphate => H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211874", "l": "CYP2S1 4-hydroxylates atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30860", "l": "dITP + H2O => dIDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682863", "l": "RNF168 binds DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33525", "l": "acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) => ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35876", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749215", "l": "MCM8 binds CDC6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13551", "l": "diphosphate + GDP-beta-L-fucose => beta-L-fucose 1-phosphate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59356", "l": "H2O + lactobiono-1,5-lactone = H(+) + lactobionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27920", "l": "2 H(+) + NADPH + propanoate => H2O + NADP(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9793472", "l": "RIPK3 binds p-S9-PRKN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168638", "l": "Activated IKK phosphorylates I-kappaB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14505", "l": "2 glutathione + thiosulfate = glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite", "d": []}, {"i": "EC:2.8.1.3", "l": "\"thiosulfate--thiol sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204850", "l": "Interaction of Tie2 and Dok-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163090", "l": "Elongation Of The Telomeric Chromosome End (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69707", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphinganine + H2O = beta-D-galactose + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60248", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450494", "l": "HuR binds mRNAs in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19127", "l": "3-hydroxypyruvate + glycine => glyoxylate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41230", "l": "(S)-4-hydroxymandelate + O2 <=> 4-hydroxyphenylglyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3899291", "l": "SUMOylation of EP300 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664850", "l": "ATM binds PEX5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41989", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) => 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15539", "l": "3-sulfopyruvate + H(+) + NADPH => (2R)-3-sulfolactate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30295", "l": "GTP + pyruvate = GDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61763", "l": "rebaudioside B + UDP-alpha-D-glucose <=> rebaudioside A + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46654", "l": "5beta-dihydroepitestosterone + NADP(+) => epitestosterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24321", "l": "an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37713", "l": "1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.11", "l": "\"2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42251", "l": "butanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxohexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001147", "l": "camalexin binding", "d": ["Binding to camalexin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31176", "l": "(2E)-2-methylpropenoyl-CoA + H2O => (S)-3-hydroxyisobutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371353", "l": "Soluble TNF-α binds TNFR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9707690", "l": "BACH1 binds MAFK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50043", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247569", "l": "PADI4 deiminates Histones (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984671", "l": "Chromokinesins form dimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15164", "l": "4-hydroxyphenylacetate + H(+) + NADH + O2 <=> H2O + homogentisate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694409", "l": "Nucleotide exchange on RAB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170149", "l": "Translocation of active Cdc25C to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44050", "l": "8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22279", "l": "2-oxoaldehyde + H2O + NAD(+) <=> a 2-oxocarboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51690", "l": "H(+) + keto-L-tagatose + NADH => galactitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64349", "l": "2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+) => deacetylpyripyropene E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39367", "l": "(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH = (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32002", "l": "(2E,6E)-farnesyl diphosphate <=> bicyclogermacrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687097", "l": "p-S857 NCOA3 binds ETV4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018808", "l": "RAC3 binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004751", "l": "ribose-5-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64211", "l": "an N-(fatty acyl)-L-glutamine + H2O <=> a fatty acid + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202164", "l": "Translocation of PDK1 to Plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140306", "l": "lipoprotein releasing activity", "d": ["The activity of recognizing mature outer membrane lipoproteins in the inner membrane and releasing from the inner membrane so that they can be transported across the periplasmic space to their target location, the outer membrane. This function exists in diderm bacteria, mediated by the LolCDE complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047832", "l": "D-pinitol dehydrogenase activity", "d": ["Catalysis of the reaction: 5D-5-O-methyl-chiro-inositol + NADP+ = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44816", "l": "1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-12 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51193", "l": "(R)-2-hydroxyglutarate + NADP(+) => 2-oxoglutarate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482770", "l": "Release of platelet secretory granule components (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65798", "l": "1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52885", "l": "H2O + N-phenylhydroxylamine + 2 NADP(+) => 2 H(+) + 2 NADPH + nitrobenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018598", "l": "hydroxymethylsilanetriol oxidase activity", "d": ["Catalysis of the reaction: hydroxymethylsilanetriol + O2 + 2 H+ + 2 e- = 2 H2O + formylsilanetriol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48333", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23811", "l": "(S)-scoulerine + S-adenosyl-L-methionine <=> (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857305", "l": "Activated CEBPB and NFKB complex bind IL6 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71449", "l": "D-alanine(out) + Na(+)(out) => D-alanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63723", "l": "losartan + UDP-alpha-D-glucuronate <=> losartan-2-N-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141046", "l": "Atg8-family conjugating enzyme activity", "d": ["Isoenergetic transfer of an Atg8 family modifer from one protein to a phosphatidylethanolamine or  phosphatidylserine on a membrane, via the reaction X-Atg8 + Y = Y-Atg8 + X."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043734", "l": "DNA-N1-methyladenine dioxygenase activity", "d": ["Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047336", "l": "5-methyldeoxycytidine-5'-phosphate kinase activity", "d": ["Catalysis of the reaction: 2'-deoxy-5-methyl-5'-cytidylate + ATP = 5-methyldeoxycytidine diphosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54363", "l": "4-methyl-2-oxopentanoate + H(+) <=> 3-methylbutanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51453", "l": "O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate => beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72524", "l": "1,6-dihydroxyphenazine + S-adenosyl-L-methionine => 1-hydroxy-6-methoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10340", "l": "(2E,6E)-farnesyl diphosphate = (-)-vetispiradiene + diphosphate", "d": []}, {"i": "EC:4.2.3.21", "l": "\"vetispiradiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51728", "l": "dihydroxyacetone phosphate + H2O = dihydroxyacetone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64922", "l": "a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate => a 2'-deoxyribonucleoside 5'-diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264615", "l": "Loading of acetylcholine in synaptic vesicles (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874082", "l": "MET phosphorylates PTK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69021", "l": "L-aspartate + NADPH + O2 => H2O + N-hydroxy-L-aspartate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54804", "l": "2 4-sulfanylbutanoate + NAD(+) = 4,4'-disulfanyldibutanoate + H(+) + NADH", "d": []}, {"i": "EC:1.8.1.20", "l": "\"4,4'-dithiodibutanoate disulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22982", "l": "a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] => a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004498", "l": "calcidiol 1-monooxygenase activity", "d": ["Catalysis of the reaction: calcidiol + H+ + NADPH + O2 = calcitriol + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44621", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56831", "l": "2,3,6-trichlorohydroquinone + chloride + glutathione disulfide <=> 2,3,5,6-tetrachlorohydroquinone + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35962", "l": "H(+) + NADPH + O2 + tryprostatin B <=> demethoxyfumitremorgin C + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57061", "l": "2''-O-acetyl-ADP-D-ribose + H2O => acetate + ADP-D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015227", "l": "acyl carnitine transmembrane transporter activity", "d": ["Enables the transfer of acyl carnitine from one side of a membrane to the other. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane."]}, {"i": "REACT:R-HSA-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22913", "l": "L-valine + pyruvate => 3-methyl-2-oxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60384", "l": "enterobactin + H2O = N-(2,3-dihydroxybenzoyl)-L-serine trimer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71373", "l": "epitestosterone 17-sulfate(in) + 2 Na(+)(in) => epitestosterone 17-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592371", "l": "Initial activation of proMMP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871227", "l": "RET binds GFRA4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53371", "l": "5,6-dihydrouridine(17) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(17) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.23", "l": "\"PepB aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168459", "l": "Lyn activates ERK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57986", "l": "(20S)-ginsenoside Rd + H(+) + UDP => (20S)-ginsenoside Rg3 + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605723", "l": "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102824", "l": "UDP-L-rhamnose:quercetin 3-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-7-olate + UDP-L-rhamnose <=> H+ + quercetin 3-O-rhamnoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75048", "l": "N(omega),N(omega)-dimethyl-L-arginine(out) => N(omega),N(omega)-dimethyl-L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008043", "l": "MAPK8 phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102476", "l": "pinocembrin 2-hydroxylase activity", "d": ["Catalysis of the reaction: pinocembrin + NADPH + O2 + H+ <=> 2,5,7-trihydroxyflavanone + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710106", "l": "ELANE cleaves GSDMD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710263", "l": "GZMB cleaves GSDME (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14573", "l": "D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O", "d": []}, {"i": "EC:4.2.1.40", "l": "\"glucarate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454916", "l": "The ABCC family mediates organic anion transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48882", "l": "a quinol + CO2 => a quinone + CO + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40141", "l": "(9Z)-octadecenoate + CoA + H(+) => (9Z)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39697", "l": "(R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+) => 3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51544", "l": "D-ribulose = D-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29161", "l": "3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out) => 3 a menaquinol(in) + 2 H(+)(out) + nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54307", "l": "n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate <=> n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43176", "l": "cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.310", "l": "\"25S rRNA (cytosine(2870)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66861", "l": "dimethylallyl diphosphate + 4 isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56643", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42564", "l": "uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA", "d": []}, {"i": "EC:5.4.99.45", "l": "\"tRNA pseudouridine(38/39) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36372", "l": "(2S)-hydroxybutanoate + NAD(+) => 2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963734", "l": "IL9 binds IL9R:JAK1 and IL2RG:JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52587", "l": "chenodeoxycholoyl-CoA + NAD(+) <=> 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51498", "l": "a sphingoid 1-phosphate + ADP + H(+) => a sphingoid base + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5336184", "l": "GPR37L binds prosaposin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807008", "l": "PTPRJ dephosphorylates MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26415", "l": "a secondary aliphatic amine + H2O + O2 => a primary amine + an aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65585", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] => 8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34292", "l": "2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose => 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15058", "l": "(9Z)-octadecenoyl-[ACP] + H2O => (9Z)-octadecenoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29101", "l": "a menaquinol + 4 H(+)(out) + NAD(+) => a menaquinone + 5 H(+)(in) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201637", "l": "Caspase-mediated cleavage of plectin-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849085", "l": "ARHGAP35 binds RHOA:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0003878", "l": "ATP citrate synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + ADP + H+ + oxaloacetate + phosphate = ATP + citrate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65672", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.291", "l": "\"(R,S)-reticuline 7-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11061", "l": "ATP + L-isoleucine + tRNA(Ile) => AMP + diphosphate + L-isoleucyl-tRNA(Ile)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549304", "l": "OCT3 mediates renal clearance of organic cations (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63919", "l": "5-fluorouridine + ATP <=> 5-fluorouridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12271", "l": "2-oxoglutarate + putrescine <=> 1-pyrroline + H2O + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70234", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+) <=> (S)-2-benzoylsuccinyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24967", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210439", "l": "glutamate uptake by astrocytes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73250", "l": "ladanein + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873917", "l": "Translocation of STAT1 dimer to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682026", "l": "MRN bound to shortened telomeres activates ATM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938815", "l": "RNF152 polyubiquitinates RRAGA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75545", "l": "(2E)-decenoyl-[ACP] + glycine + H2O => (3R)-3-[(carboxylmethyl)amino]decanoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29340", "l": "(S)-malate(in) + 2 H(+)(in) => (S)-malate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1183032", "l": "Expression of GLUT4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31166", "l": "(3S)-hydroxyhexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34034", "l": "2'-N-acetylparomamine + H2O <=> acetate + paromamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170964", "l": "FRS2 binds to active TrkA receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19174", "l": "H(+) + NADH + naphthalene + O2 => (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17317", "l": "chlorophyllide a + H(+) + phytyl diphosphate = chlorophyll a + diphosphate", "d": []}, {"i": "EC:2.5.1.62", "l": "\"chlorophyll synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16936", "l": "1-aminocyclopropane-1-carboxylate + H2O <=> 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14660", "l": "aldehydo-D-ribose 5-phosphate <=> D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17108", "l": "malonyl-[ACP] + S-adenosyl-L-methionine <=> malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41071", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53347", "l": "5,6-dihydrouridine(20a) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20a) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61522", "l": "3-tyramine + A + H2O => AH2 + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13552", "l": "beta-L-fucose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352268", "l": "Cleavage of Satb1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433725", "l": "Interaction of Afadin with F-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111930", "l": "Adenylate cyclase produces cAMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11682", "l": "AMP + diphosphate + GMP + 2 H(+) + L-glutamate => ATP + H2O + L-glutamine + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070974", "l": "POU domain binding", "d": ["Binding to a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14010", "l": "2 dimethylallyl diphosphate => (R,R)-chrysanthemyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60842", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein] => a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877493", "l": "TNFRSF18 (GITR) gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70520", "l": "(R)-octopamine + S-adenosyl-L-methionine => (R)-synephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649856", "l": "Oxidative damage to the AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71199", "l": "L-ornithine(in) = L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112266", "l": "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60179", "l": "5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA + H2O <=> 5-methylaminomethyl-2-selenouridine(34) in tRNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42660", "l": "NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": []}, {"i": "EC:1.1.1.374", "l": "\"UDP-N-acetylglucosamine 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46907", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) <=> a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-844619", "l": "AIM2 binds dsDNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222644", "l": "TrxA/B1 reactivates Tpx (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-481009", "l": "Exocytosis of platelet dense granule content (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65475", "l": "2-methylbutanoyl-CoA + ethanol <=> CoA + ethyl 2-methylbutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11425", "l": "ATP + L-threonyl-[myosin heavy-chain] => ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52996", "l": "[eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH = [eIF5A protein]-deoxyhypusine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68765", "l": "(R)-3-phenyllactate + 3 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022D + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975125", "l": "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14046", "l": "1-carboxyvinyl carboxyphosphonate + H(+) => 3-(hydrohydroxyphosphoryl)pyruvate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49335", "l": "2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426223", "l": "Cation influx mediated by TRPC3/6/7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46670", "l": "5beta-dihydrodeoxycorticosterone + NADP(+) => 21-hydroxyprogesterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200406", "l": "CPT1A,B transfers PALM to CAR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19119", "l": "(R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical => dopamine + 2 L-ascorbate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62332", "l": "ADP + ATP = adenosine 3'-diphosphate,5'-diphosphate + AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36863", "l": "(9Z)-octadecenoyl-CoA + AH2 + O2 = (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31720", "l": "11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018686", "l": "6-hydroxy pseudo-oxynicotine monooxygenase activity", "d": ["Catalysis of the reaction: 2 6-hydroxypseudooxynicotine + O2 = 2 2,6-dihydroxypseudooxynicotine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111883", "l": "Hydrolysis of phosphatidylcholine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9716913", "l": "ESR1 binds ESR1 antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948583", "l": "miR-17 microRNA binds CNOT6L mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70982", "l": "Fumarate + H2O <=> (S)-Malate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212352", "l": "Formation of ARC coactivator complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9613497", "l": "Unwinding DNA for the nascent transcript (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35139", "l": "(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O = CO2 + 2 CoA + demethoxycurcumin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418904", "l": "A1 and A3 receptors bind adenosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865275", "l": "PDGF-BB clevage by Furin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48917", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b => CMP + ganglioside GD1c + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019170", "l": "methylglyoxal reductase (NADH-dependent) activity", "d": ["Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106293", "l": "NADH oxidase H202-forming activity", "d": ["Catalysis of the reaction: NADH + H+ + O2 = NAD + hydrogen peroxide (H2O2)."]}, {"i": "RHEA:11264", "l": "H(+) + NADH + O2 = H2O2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20822", "l": "choline + H(+) + sulfate => choline sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707659", "l": "Hemes:LY96 activates TLR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940134", "l": "FOLR2 binds FOLA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18928", "l": "L-gulono-1,4-lactone + NADP(+) <=> D-glucurono-3,6-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865276", "l": "PDGF-AB clevage by Furin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0035254", "l": "glutamate receptor binding", "d": ["Binding to a glutamate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12543", "l": "ATP + L-alanine + tRNA(Ala) <=> AMP + diphosphate + L-alanyl-tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42927", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49326", "l": "all-trans-capsorubin => (5R,6S)-5,6-epoxi-capsanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36645", "l": "H(+) + questin + S-adenosyl-L-homocysteine => emodin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56175", "l": "FMN + O2 <=> 8-demethyl-8-formylriboflavin 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042124", "l": "1,3-beta-glucanosyltransferase activity", "d": ["Catalysis of the splitting and linkage of (1->3)-beta-D-glucan molecules, resulting in (1->3)-beta-D-glucan chain elongation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74726", "l": "Dissociation of insulin from insulin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54240", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69946", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64459", "l": "L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53244", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] = cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32199", "l": "androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.30", "l": "\"3-ketosteroid 9alpha-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43728", "l": "methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.127", "l": "\"methyl farnesoate epoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680248", "l": "Phosphorylation of extracellular domain KIT mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854209", "l": "TBC1D10A binds JFC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43304", "l": "3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer = 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103042", "l": "4-hydroxy-L-threonine aldolase activity", "d": ["Catalysis of the reaction: 4-hydroxy-L-threonine <=> glycolaldehyde + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71415", "l": "3,3',5-triiodo-L-thyronine(out) + L-phenylalanine(in) = 3,3',5-triiodo-L-thyronine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40247", "l": "H2O + rhodomycin D = 10-carboxy-13-deoxycarminomycin + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199579", "l": "KIR2DL4 interacting with HLA-G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22154", "l": "a ubiquinol + D-glucono-1,5-lactone => a ubiquinone + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013009", "l": "RHOA binds effectors at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24168", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050140", "l": "nitrate reductase (cytochrome) activity", "d": ["Catalysis of the reaction: ferrocytochrome + nitrate = ferricytochrome + nitrite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49465", "l": "2,6-dihydroxybenzoate + H(+) => CO2 + resorcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701537", "l": "p-Y705, S727 STAT3 dimer binds CD274 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849906", "l": "SALM1 binds NMDA receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674385", "l": "p-T,Y MAPKs dimerize (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852010", "l": "BTNL2 binds activated T cells surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61245", "l": "H2O + L-tryptophan + O2 => H2O2 + indole-3-pyruvate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186786", "l": "Autophosphorylation of PDGF beta receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30038", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 <=> benzene-1,2,4-triol + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24481", "l": "a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O => a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45569", "l": "[heparosan](n) => [acharan](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40055", "l": "1,2,3-trioctanoylglycerol + H2O = 2,3-dioctanoyl-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20975", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33924", "l": "(1R,4R)-5-oxo-1,2-campholide => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65114", "l": "aculene C + CO2 + H2O + succinate => 2-oxoglutarate + aculene D + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877620", "l": "ECE2 cleaves EDN1(53-90) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868118", "l": "MAPK12 phosphorylates PTPN3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689630", "l": "BAP1 binds BAP1-interacting complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.17", "l": "\"corrinoid adenosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70931", "l": "chloride(out) + dopamine(out) + 2 Na(+)(out) = chloride(in) + dopamine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140761", "l": "sequestered tissue factor -> tissue factor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18837", "l": "10-deacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C", "d": []}, {"i": "EC:2.3.1.163", "l": "\"10-hydroxytaxane O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55855", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395992", "l": "p-T,4S-IRF3 is dimerized (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5082356", "l": "HSF1-mediated gene expression (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432067", "l": "Aquaporin-4 passively transports water out of cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30409", "l": "oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin] => hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26394", "l": "all-trans-zeaxanthin + 2 O2 => 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102806", "l": "4-coumaroyl-CoA:cyanidin-3,5-diglucoside-6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + cyanin betaine <=> shisonin + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31894", "l": "2-hydroxy-1-phenyl-1-propanone + NADP(+) <=> 1-phenyl-1,2-propanedione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.25", "l": "\"branched-chain alpha-keto acid dehydrogenase system\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58049", "l": "2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA => 2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34924", "l": "nitrate(in) => nitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28977", "l": "H(+)(in) + L-asparagine(out) => H(+)(out) + L-asparagine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73799", "l": "dimethylallyl diphosphate + isoechinulin A = dehydroechinulin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047037", "l": "salutaridine reductase (NADPH) activity", "d": ["Catalysis of the reaction: (7S)-salutaridinol + NADP+ = H+ + NADPH + salutaridine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730847", "l": "Hydrolysis of PIP2 by PLCG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9663511", "l": "BIL binds GSTA1, FABP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693250", "l": "RHOD binds effectors at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27470", "l": "H2O + N,N'-diacetylchitobiose => acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72691", "l": "Formation of the 43S pre-initiation complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15860", "l": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+) <=> 17alpha-hydroxyprogesterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013145", "l": "RAC1 binds effectors at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909724", "l": "Recruitment of IFNAR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66621", "l": "5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => (25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004855", "l": "xanthine oxidase activity", "d": ["Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69818", "l": "cathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33918", "l": "4-(methylamino)butanoate + H2O + O2 <=> H2O2 + methylamine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.18", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004939", "l": "beta-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66007", "l": "coenzyme M + methyl-Co(III)-[glycine betaine-specific corrinoid protein] <=> Co(I)-[glycine betaine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47353", "l": "a hexanoate ester + H2O => an aliphatic alcohol + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71684", "l": "2 H(+)(out) + L-aspartyl-glycine(out) => 2 H(+)(in) + L-aspartyl-glycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42834", "l": "(S)-3-acetyloctanal + CO2 => (2E)-octenal + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75839", "l": "H(+)(in) + K(+)(in) + Na(+)(out) + serotonin(out) = H(+)(out) + K(+)(out) + Na(+)(in) + serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12989", "l": "a dolichyl beta-D-mannosyl phosphate + H2O = a dolichyl phosphate + D-mannose + H(+)", "d": []}, {"i": "EC:3.1.4.49", "l": "\"dolichylphosphate-mannose phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0016274", "l": "protein-arginine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693198", "l": "RHOD binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73806", "l": "AIR + CO2 => CAIR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48928", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9709109", "l": "DHFR dimer binds DHFR inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68960", "l": "DNA polymerase epsilon binds at the origin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47719", "l": "4-pregnen-20,21-diol-3-one + NAD(+) <=> 21-hydroxyprogesterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30464", "l": "(2Z,6Z)-farnesyl diphosphate => (+)-alpha-santalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5226999", "l": "ADD1:ADD3 binds DMTN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60617", "l": "N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine => ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790905", "l": "Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042293", "l": "Hub1 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-877361", "l": "Pyrin binds ASC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14342", "l": "2-oxoglutarate + glyoxylate + H(+) => 2-hydroxy-3-oxoadipate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112755", "l": "SOCS3 binds IL6ST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65989", "l": "previtamin D3 => calciol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071967", "l": "lipopolysaccharide core heptosyltransferase activity", "d": ["Catalysis of the reaction: glucosyl-heptosyl2-KDO2-lipid A-phosphate + ADP-L-glycero-beta-D-manno-heptose = glucosyl-heptosyl3-KDO2-lipid A-phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849900", "l": "SALMs1-3 bind each other in cis interactions (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23892", "l": "3-nitropropanoate + NADP(+) = 3-nitroacrylate + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.16", "l": "\"beta-nitroacrylate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58143", "l": "acetyl-AMP + cytidine(34) in elongator tRNA(Met) <=> AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9709098", "l": "DHFR dimer reduces FOLA to DHF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74723", "l": "Endosome acidification (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.26", "l": "\"beta-fructofuranosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65546", "l": "an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc => ganglioside GM1 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28802", "l": "H2O + L-prolinylglycine <=> glycine + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26162", "l": "thalianol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68960", "l": "DNA polymerase epsilon binds at the origin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674093", "l": "PDGFRs bind type I TKI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848829", "l": "CBL autoubiquitinates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29124", "l": "nitrate(out) + ubiquinol-8(in) => H2O(out) + nitrite(out) + ubiquinone-8(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47973", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4837364", "l": "Secretion of SOD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047770", "l": "carboxylate reductase activity", "d": ["Catalysis of the reaction: an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8979071", "l": "KDM6B binds iron (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16389", "l": "4-hydroxybenzoate + 2 H(+) + NADH + O2 = CO2 + H2O + hydroquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10789", "l": "2-dehydro-D-gluconate + ATP => 6-phospho-2-dehydro-D-gluconate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809764", "l": "SBF1 binds MTMR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201622", "l": "Caspase-mediated cleavage of gelsolin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034944", "l": "3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA + NAD+ = 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + NADH+ + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800315", "l": "MST1 binds MST1R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.48", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180710", "l": "Rev:importin beta:B23 recruited to the nuclear pore (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390593", "l": "ATP Hydrolysis By Myosin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64066", "l": "(R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1R,2R)-pseudoephedrine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043820", "l": "propionyl-CoA dehydrogenase activity", "d": ["Catalysis of the irreversible NADH-dependent formation of propionyl-CoA from acryloyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62300", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH = 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17399", "l": "a 3-oxoacyl-[ACP] + H(+) + NADPH => a (3R)-hydroxyacyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51510", "l": "CO2 + succinate + trans-4-hydroxy-L-proline => 2-oxoglutarate + L-proline + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39106", "l": "ATP + H2O + sitosterol(in) <=> ADP + H(+) + phosphate + sitosterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0017113", "l": "dihydropyrimidine dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37717", "l": "1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941895", "l": "Formation of CDK4/6:CCND complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10964", "l": "ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.17", "l": "\"xylulokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64258", "l": "CoA + H(+) + N-dodecanoylglycine => dodecanoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71203", "l": "L-homoarginine(in) = L-homoarginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32059", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O = (R)-glycerate + D-glucose", "d": []}, {"i": "EC:3.2.1.208", "l": "\"glucosylglycerate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37230", "l": "(E,E)-sorbate + H(+) <=> (E)-1,3-pentadiene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871226", "l": "RET binds GFRA1,GFRA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474266", "l": "Formation of collagen fibrils (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296301", "l": "CCRL2 binds CCL19 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23217", "l": "benzoyl-CoA + H(+) + NADPH + O2 => 3-hydroxybenzoyl-CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73587", "l": "CTP(out) + UMP(in) = CTP(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36672", "l": "(17Z)-hexacosenoyl-CoA + sphinganine => CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17756", "l": "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine <=> (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867344", "l": "OMA1 hydrolyses OPA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75364", "l": "thymidine(in) => thymidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37943", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9619756", "l": "NR1H2 binds ABCA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2169046", "l": "Degradation of TGF-beta receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52982", "l": "7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin] => a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56339", "l": "ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033782", "l": "24-hydroxycholesterol 7alpha-hydroxylase activity", "d": ["Catalysis of the reaction: (24S)-hydroxycholesterol + O2 + reduced [NADPH-hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H+ + H2O + oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28319", "l": "scutellarein + UDP-alpha-D-glucuronate => scutellarin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-990489", "l": "Kinesin-13 is a dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031740", "l": "type A cholecystokinin receptor binding", "d": ["Binding to a type A cholecystokinin receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016158", "l": "3-phytase activity", "d": ["Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57285", "l": "a guanosine in RNA + methylglyoxal => an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710101", "l": "CASP4, CASP5 cleave GSDMD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69359", "l": "H(+) + hypobromite + L-tyrosyl-[protein] <=> 3-bromo-L-tyrosyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564169", "l": "Collagen type VIII degradation by MMP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18039", "l": "N-carbamoylputrescine + NH4(+) => agmatine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16071", "l": "NH4(+) + uridine => cytidine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60362", "l": "dehydro coenzyme F420-0 + FMNH2 => FMN + H(+) + oxidized coenzyme F420-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11114", "l": "(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate => H2O + isochorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354173", "l": "Activation of Rap1 by cytosolic GEFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198756", "l": "ERK1/2 phosphorylates MSK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009676", "l": "low-affinity sulfate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5604929", "l": "Activated protein C binds Protein S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46734", "l": "(2S,6)-dimethylheptanoyl-CoA => (2R,6)-dimethylheptanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18890", "l": "D-glucose 6-phosphate + UDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32992", "l": "2 a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112727", "l": "Serine phosphorylation of STATs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875183", "l": "CBL monoubiquitinates activated MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31495", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.274", "l": "\"glucosylceramide beta-1,4-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982017", "l": "Active G alpha (q) binds RGS proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21320", "l": "A + D-sorbitol = AH2 + keto-L-sorbose", "d": []}, {"i": "EC:1.1.99.21", "l": "\"D-sorbitol dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22446", "l": "(E)-coniferaldehyde + H(+) + NADPH => (E)-coniferol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875183", "l": "CBL monoubiquitinates activated MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46858", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58589", "l": "dihydroprecondylocarpine acetate + NADPH => (+)-vincadifformine + acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374899", "l": "Release of noradrenaline  at the synapse (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43078", "l": "H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase] => erythrodiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029471", "l": "Hydrolysis of PC to PA by PLD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69811", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004462", "l": "lactoylglutathione lyase activity", "d": ["Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804383", "l": "PRMT5 methylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58298", "l": "25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine => 25-substituted-cholesterol + beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120243", "l": "2-iminopropanoate deaminase activity", "d": ["Catalysis of the reaction: 2-iminopropanoate + H2O = NH4(+) + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615721", "l": "HSPA8 binds substrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51015", "l": "a monoacyl-sn-glycero-3-phosphocholine + H2O <=> a monoacylglycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29375", "l": "AMP + H2O = adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73989", "l": "diphosphate + discoidol => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69840", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22S)-22-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10604", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine", "d": []}, {"i": "EC:3.1.4.3", "l": "\"phospholipase C\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65647", "l": "(4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73766", "l": "2 ATP + L-alanine + L-tryptophan <=> 2 ADP + cyclo(L-tryptophyl-L-alanyl) + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5444523", "l": "Formation of MSH1:PMS2 Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102911", "l": "(-)-secoisolariciresinol dehydrogenase activity", "d": ["Catalysis of the reaction: (-)-secoisolariciresinol + NAD <=> H+ + (-)-lactol + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27278", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41164", "l": "1-O-hexadecyl-2-amino-sn-glycerol + ATP => 1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55854", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.7", "l": "\"ribonuclease F\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.59", "l": "\"long-chain fatty acid adenylase/transferase FadD26\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5620975", "l": "MLKL binds PIPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67267", "l": "(2S,4S)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine <=> (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33638", "l": "ATP + CoA + docosanoate <=> AMP + diphosphate + docosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211206", "l": "Translocation of DFF to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694583", "l": "ABHD4 hydrolyses NAPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26261", "l": "H2O + isopimara-7,15-dienal + NADP(+) = 2 H(+) + isopimarate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32151", "l": "9alpha-copalyl diphosphate = (12E)-9alpha-labda-8(17),12,14-triene + diphosphate", "d": []}, {"i": "EC:4.2.3.99", "l": "\"labdatriene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62225", "l": "H(+) + NADPH + neopatulin => (E)-ascladiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210277", "l": "Interaction of PECAM-1 and SHP-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59263", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4088130", "l": "PLK1 binds FOXM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43854", "l": "3-oxo-dotriacontanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + triacontanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.137", "l": "\"arsenite methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18582", "l": "ethanolamine + H2O + O2 => glycolaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73826", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046180", "l": "KSPG is secreted from the cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604712", "l": "Initial activation of proMMP7 by trypsin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54347", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33755", "l": "H2O + N-hexadecanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5620918", "l": "ASAP1 dimer binds membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29623", "l": "alpha-maltopentaose + beta-maltose = alpha-maltohexaose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73176", "l": "ADP(in) + FMN(out) => ADP(out) + FMN(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68201", "l": "1,2-dihexanoylglycerol + hexadecanoyl-CoA => 1,2-dihexanoyl-3-hexadecanoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665727", "l": "FMNL2 binds CDC42:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918227", "l": "Recruitment of TRAF3 to MAVS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617853", "l": "GADD45A gene expression is stimulated by FOXO3,FOXO4,(FOXO1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74678", "l": "AH2 + archaeol + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaeol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033703", "l": "3beta-hydroxy-5beta-steroid dehydrogenase activity", "d": ["Catalysis of the reaction: 3beta-hydroxy-5beta-pregnane-20-one + NADP+ = 5beta-pregnan-3,20-dione + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58509", "l": "(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O => (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783670", "l": "CRLF1 binds CLCF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35669", "l": "a 1,2-diacylglycerol + a fatty acid + H(+) => a triacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047723", "l": "inosinate nucleosidase activity", "d": ["Catalysis of the reaction: H2O + IMP = D-ribose 5-phosphate + hypoxanthine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24443", "l": "ATP + H2O + phosphate(out) <=> ADP + H(+) + 2 phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25034", "l": "all-trans-retinol + NADP(+) => all-trans-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029473", "l": "Branching and elongation of mother and daughter filaments (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210294", "l": "Interaction of PECAM-1 and SHP-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791075", "l": "Expression of DNAJB11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73684", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphing-4-enine => a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43220", "l": "guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.242", "l": "\"16S rRNA (guanine(1516)-N(2))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38401", "l": "(9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9754974", "l": "ADK phosphorylates RBV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71657", "l": "a thymidine in DNA + ADP-D-ribose => an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15887", "l": "(S)-lactaldehyde + H(+) + NADPH => NADP(+) + propane-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32527", "l": "N,N'-diacetylchitobiose + phosphate = N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine", "d": []}, {"i": "EC:2.4.1.280", "l": "\"N,N'-diacetylchitobiose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22967", "l": "H(+) + L-ornithine <=> CO2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042349", "l": "guiding stereospecific synthesis activity", "d": ["The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928640", "l": "PAKs phosphorylate MLC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44043", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> 14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-996755", "l": "ZFPM proteins bind GATA proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42007", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702613", "l": "ponatinib-resistant FLT3 mutants don't bind ponatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33369", "l": "D-glucose 6-phosphate(in) + L-histidyl-[protein] => D-glucose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47890", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1964496", "l": "STING binds TRIM32 or TRIM56  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450187", "l": "TAK1 is activated within the TAK1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44985", "l": "(R)-carnitine + 3-methylbutanoyl-CoA => CoA + O-3-methylbutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75090", "l": "32-hydroxy-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-oxo-24,25-dihydrolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70481", "l": "TPI1 isomerizes GA3P to DHAP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74329", "l": "O-propanoyl-(R)-carnitine(out) => O-propanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018481", "l": "4-hydroxymuconic-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: <stereo>cis,trans</stereo>-4-hydroxymuconate semialdehyde + H2O + NAD+ = 2 H+ + maleylacetate + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35585", "l": "D-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782443", "l": "QTRT1:QTRTD1 exchange guanine for queuosine at guanosine-34 of tRNA(Tyr) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042960", "l": "antimonite secondary active transmembrane transporter activity", "d": ["Enables the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026000", "l": "Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57695", "l": "2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 cob(I)inamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73427", "l": "genkwanin + O2 + reduced [NADPH--hemoprotein reductase] = H2O + oxidized [NADPH--hemoprotein reductase] + scutellarein 7-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047219", "l": "monoterpenol beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: (-)-menthol + UDP-D-glucose = (-)-menthyl beta-D-glucoside + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64381", "l": "3 A + phytyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66032", "l": "alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49960", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 = 5,10-dihydrophenazine + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55689", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O => 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444433", "l": "Cho transports from the extracellular space to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621035", "l": "EGR1 binds the TF gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13718", "l": "2-C-methyl-D-erythritol 4-phosphate + NADP(+) => 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68883", "l": "ATP + H(+) + NADPH + salicylate <=> AMP + diphosphate + NADP(+) + salicylaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762333", "l": "ANGPTL4 binds to CDH11v (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73644", "l": "CTP(out) + IDP(in) => CTP(in) + IDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729835", "l": "SARS-CoV-2 nsp9 binds to 7SL RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676133", "l": "CD74 binds MIF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.74", "l": "\"venombin A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20667", "l": "1,5-anhydro-D-fructose + H(+) + NADPH => 1,5-anhydro-D-glucitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39162", "l": "(3R)-hydroxyhexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13828", "l": "GDP-alpha-D-rhamnose + NAD(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51280", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8934446", "l": "Activated PKC phosphorylates SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33553", "l": "a fatty acid + sphinganine => an N-acylsphinganine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614271", "l": "Autocleavage of ADGRG6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65085", "l": "asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72428", "l": "chloride(in) + K(+)(in) => chloride(out) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45433", "l": "H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62984", "l": "H2O + hexadecanamide = hexadecanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35090", "l": "H2O + N'-monoacetylchitobiose-6'-phosphate <=> D-glucosamine + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31641", "l": "H(+) + mycinamicin IV + S-adenosyl-L-homocysteine => mycinamicin III + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53695", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O <=> H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2314686", "l": "ASA- acetylates PTGS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032564", "l": "dATP binding", "d": ["Binding to dATP, deoxyadenosine triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68485", "l": "(2R)-2-hydroperoxydodecanoate + H(+) => CO2 + H2O + undecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12102", "l": "H2O + microthecin => 1,5-anhydro-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700171", "l": "Active ALK phosphorylates PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015554", "l": "tartrate transmembrane transporter activity", "d": ["Enables the transfer of tartrate from one side of a membrane to the other. Tartrate is the anion of 2,3-dihydroxybutanedioic acid, one of the aldaric acids. The L(+) enantiomer occurs widely in plants, especially in grape juice, and in fungi and bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.26", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052635", "l": "C-20 gibberellin 2-beta-dioxygenase activity", "d": ["Catalysis of the reaction: a C-20 gibberellin + 2-oxoglutarate + O2 = a C-20 2-beta-hydroxygibberellin + succinate + CO2. C-20 gibberellin refers to a gibberellin with twenty carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73046", "l": "creatine(in) <=> creatine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784204", "l": "JAKs bind OSMR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40217", "l": "FAD + H(+) + H2O2 => FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22790", "l": "(methylsulfanyl)acetate + H(+) + L-methionine => dimethylsulfonioacetate + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424476", "l": "Activation of RAC1 by VAV2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49899", "l": "(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate <=> 5,10-dihydrophenazine-1,6-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.6.-", "l": "\"With a nitrogenous group as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679266", "l": "Beclin-1 complex translocates to the ER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66320", "l": "2',3'-cGAMP(out) = 2',3'-cGAMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32253", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60796", "l": "2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2 = 3 CO2 + gibberellin A20 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.3", "l": "\"glucan 1,4-alpha-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-984606", "l": "Kinesin-5 is a homotetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25862", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+) => GTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031737", "l": "CX3C chemokine receptor binding", "d": ["Binding to a CX3C chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672978", "l": "RAF phosphorylates MAP2K dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71341", "l": "chloride(in) + L-tyrosine(in) + 2 Na(+)(in) => chloride(out) + L-tyrosine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76080", "l": "a dicarboxylate(in) + L-sepiapterin(out) => a dicarboxylate(out) + L-sepiapterin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31901", "l": "H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase] => indole + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62870", "l": "H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+) => 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44994", "l": "CoA + O-2-methylbutanoyl-(R)-carnitine => (R)-carnitine + 2-methylbutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47440", "l": "(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) = 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67789", "l": "2 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a cardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182986", "l": "CBL-mediated ubiquitination of CIN85 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20507", "l": "5-oxo-L-proline + an L-alpha-amino acid => an alpha-(gamma-L-glutamyl)-L-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685605", "l": "SLAMF7 binds SLAMF7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50322", "l": "1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14254", "l": "guanosine 3',5'-bis(diphosphate) + H2O => diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45730", "l": "(E)-caffeyl aldehyde + H(+) + NADPH => (E)-caffeyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51262", "l": "(10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27461", "l": "D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) = diphosphate + GDP-D-glycero-alpha-D-manno-heptose", "d": []}, {"i": "EC:2.7.7.71", "l": "\"D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36912", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23473", "l": "2 alpha,alpha'-trehalose 6-mycolate => alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57109", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798372", "l": "ATM phosphorylates DYRK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661710", "l": "An unknown oxidase oxidises D-UBGN to UBN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12404", "l": "D-glucose + UDP-alpha-D-galactose = H(+) + lactose + UDP", "d": []}, {"i": "EC:2.4.1.22", "l": "\"lactose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419861", "l": "Melanospin is stimulated by light (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59022", "l": "(9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+) => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16414", "l": "(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + L-lysyl-[lipoyl-carrier protein] => (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + L-lysyl-[glycine-cleavage complex H protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59908", "l": "H2O + hexanal + NADP(+) = 2 H(+) + hexanoate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48050", "l": "D-galactose + ganglioside GM2 (d18:1(4E)) => ganglioside GM1 (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40346", "l": "3-oxohexadecanedioyl-CoA + CoA <=> acetyl-CoA + tetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45622", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine => H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60667", "l": "H2O + NADPH <=> NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53051", "l": "2-hydroxyestrone + UDP-alpha-D-glucuronate <=> 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014454", "l": "RHOG translocates to the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451309", "l": "Edited Kainate Receptor binds glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30269", "l": "L-ascorbate + L-dehydroascorbate => 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110518", "l": "Activated DTOR also phosphorylates D4EBP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75238", "l": "TRAIL binds TRAIL receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49178", "l": "12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43657", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25951", "l": "a 1,2-diacyl-sn-glycerol + CTP <=> a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690023", "l": "NUBPL binds 4Fe-4S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607753", "l": "CARD9 oligomerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55783", "l": "all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate <=> all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52249", "l": "6 H2O + 4 Mn(3+) + O2 => 12 H(+) + 4 MnO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0140702", "l": "cyclic GMP-AMP binding", "d": ["Binding to cyclic GMP-AMP (cGAMP) nucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614544", "l": "Sulfite is oxidized to sulfate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24885", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) <=> H(+) + L-glutamate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20742", "l": "(2R,3S)-tartrate => H2O + trans-2,3-epoxysuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186778", "l": "SHP2 binds to the active receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19260", "l": "a secondary alcohol + NADP(+) <=> a ketone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66913", "l": "avenanthramide C + S-adenosyl-L-methionine => avenanthramide B + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29638", "l": "D-maltopentaose + H2O <=> alpha-D-glucose + D-maltotetraose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54753", "l": "methanophenazine + reduced coenzyme F420-(gamma-L-Glu)(n) => dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50552", "l": "prostaglandin C1 = prostaglandin B1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40373", "l": "3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984001", "l": "IL35 binds IL27RA:IL12RB2 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48453", "l": "ganglioside GA2 (d18:1(4E)) + H2O => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55513", "l": "cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944242", "l": "Association of procollagen type XXVII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30245", "l": "2 H2O + 4 monodehydro-L-ascorbate radical => 4 L-ascorbate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10235", "l": "5,6-dihydrouridine 5'-monophosphate + diphosphate <=> 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47692", "l": "AH2 + neomycin C + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.25.2", "l": "\"HslU--HslV peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23144", "l": "H2O + N-acetyl-alpha-D-glucosamine + NAD(+) = 2 H(+) + N-acetyl-D-glucosaminate + NADH", "d": []}, {"i": "EC:1.1.1.240", "l": "\"N-acetylhexosamine 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30386", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-7-epi-alpha-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27851", "l": "glycine + phenylacetyl-CoA => CoA + H(+) + phenylacetylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222093", "l": "BRD7 binds TP53 and EP300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30025", "l": "pyridoxamine 5'-phosphate + pyruvate => L-alanine + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449115", "l": "IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35232", "l": "rifampicin(in) => rifampicin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73304", "l": "H(+)(in) + oxaloacetate(out) + phosphate(in) => H(+)(out) + oxaloacetate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42664", "l": "alpha-L-arabinopyanose + NADP(+) = H(+) + L-arabinono-1,4-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74494", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B <=> yaequinolone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32071", "l": "geranylgeranyl diphosphate = (13E)-labda-7,13-dien-15-yl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52821", "l": "L-serine + succinyl-CoA => CoA + O-succinyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614591", "l": "Excess cysteine yields lanthionine and H2S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65483", "l": "2-methylbutanoyl-CoA + hexan-1-ol <=> CoA + hexyl 2-methylbutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27865", "l": "3'-GMP + H2O <=> guanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.36", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35337", "l": "3-oxoisoheptadecanoyl-CoA + CO2 + CoA => H(+) + isopentadecanoyl-CoA + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111883", "l": "Hydrolysis of phosphatidylcholine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71551", "l": "5-N(alpha)-glycyl-dTMP in DNA + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + 5-C(alpha)-glycyl-dTMP in DNA + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17347", "l": "CoA + H(+) + methylmalonate => (S)-methylmalonyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24319", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32231", "l": "(6S)-NADPHX + ATP = ADP + H(+) + NADPH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53926", "l": "a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine => a secondary amine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48833", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090411", "l": "brassinosteroid binding", "d": ["Binding to a brassinosteroid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44196", "l": "3-methylundecanoate + ATP + CoA = 3-methylundecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549129", "l": "OCT1 transports organic cations into hepatic cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47286", "l": "6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64056", "l": "(1S,2R)-ephedrine + NAD(+) = (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51883", "l": "3,4,6-trichlorocatechol + O2 <=> (2Z,4E)-2,3,5-trichloromuconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28921", "l": "4-aminobutanoate(out) + L-glutamate(in) => 4-aminobutanoate(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28676", "l": "alpha-D-galactose => beta-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65536", "l": "1,3,7-trimethylurate + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + theacrine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23739", "l": "5-hydroxyisourate + H2O <=> 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690196", "l": "USP8 deubiquitinates RNF128 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199910", "l": "MSK1 activates ATF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70899", "l": "histidine => urocanate + NH4+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51783", "l": "4-prenylphlormethylbutanophenone + dimethylallyl diphosphate <=> deoxyadlupulone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66793", "l": "N-methyl-D-dopa + O2 => (3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49162", "l": "2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35508", "l": "30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799409", "l": "HIPK2 phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15470", "l": "1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71929", "l": "2 Na(+)(in) + tauroursodeoxycholate(in) => 2 Na(+)(out) + tauroursodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873929", "l": "Casein kinase II phosphorylates STARD10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-481010", "l": "Surface deployment of platelet dense granule membrane components (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59929", "l": "erythritol + NADP(+) => D-erythrose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41753", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164504", "l": "Synthesis of minus strand strong stop DNA (-sssDNA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33112", "l": "(2E,6E)-farnesyl diphosphate => beta-copaene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74799", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65130", "l": "1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41877", "l": "(3R)-hydroxydodecanoyl-[ACP] => (2E)-dodecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74858", "l": "dopamine + pyruvate <=> (R)-salsolinol-1-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0003882", "l": "CDP-diacylglycerol-serine O-phosphatidyltransferase activity", "d": ["Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22801", "l": "cycloeucalenol => obtusifoliol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672951", "l": "Inactive RAFs bind YWHAB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66920", "l": "6-deoxy-6-sulfo-D-fructose + D-erythrose 4-phosphate = (2S)-3-sulfolactaldehyde + D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0047364", "l": "desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + desulfoglucotropeolin = adenosine 3',5'-diphosphate + glucotropeolin + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19061", "l": "H2O + NADP(+) + nitrite = H(+) + NADPH + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694522", "l": "Inner coat assembly and cargo binding (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452108", "l": "Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811479", "l": "ING2 recruits EP300 to TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19738", "l": "4-(gamma-L-glutamylamino)butanoate + H2O => 4-aminobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60163", "l": "ATP + H2O + vincristine(in) <=> ADP + H(+) + phosphate + vincristine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000319", "l": "BORA binds PLK1 and AURKA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45449", "l": "H2O + N-(dodecanoyl)-sphinganine => dodecanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70541", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + GDP + H(+) => GDP-beta-L-fucose + L-threonyl-[EGF-like domain protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229152", "l": "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25106", "l": "ADP + H(+) + pyridoxamine 5'-phosphate => ATP + pyridoxamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033196", "l": "tryparedoxin peroxidase activity", "d": ["Catalysis of the reaction: tryparedoxin + hydrogen peroxide = tryparedoxin disulfide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9612509", "l": "SGK phosphorylates SRF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218836", "l": "PTK2beta binds alphaVbeta3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47805", "l": "epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25538", "l": "diphosphate + ent-sandaracopimara-8(14),15-diene => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75861", "l": "all-trans-4-oxo-13,14-dihydroretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-4-hydroxy-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022911", "l": "CSPG is secreted (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211951", "l": "CYP1B1 4-hydroxylates EST17b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72133", "l": "agmatine(in) => agmatine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59597", "l": "H2O + kynuramine + O2 => 3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30991", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58930", "l": "(6aR,11aR)-3,9-dihydroxypterocarpan + H2O => (3R,4R)-7,2',4'-trihydroxyisoflavanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73156", "l": "adenosine 3',5'-bisphosphate(out) + FMN(in) => adenosine 3',5'-bisphosphate(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050556", "l": "deacetylisoipecoside synthase activity", "d": ["Catalysis of the reaction: deacetylisoipecoside + H2O = dopamine + secologanin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52095", "l": "5-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015553", "l": "xanthosine transmembrane transporter activity", "d": ["Enables the transfer of xanthosine, xanthine riboside, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32535", "l": "(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate", "d": []}, {"i": "EC:4.2.1.132", "l": "\"2-hydroxyhexa-2,4-dienoate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032031", "l": "myosin I head/neck binding", "d": ["Binding to the head/neck region of a myosin I heavy chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18526", "l": "3-methylbutanol + NADP(+) => 3-methylbutanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75308", "l": "D-serine(in) + L-glutamine(out) + Na(+)(out) => D-serine(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44217", "l": "12-hydroxyoctadecanoate + ATP + CoA => 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442749", "l": "CaMKK autophosphorylates in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-606289", "l": "New CENPA-containing nucleosomes are deposited at the centromere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453200", "l": "SYK autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047512", "l": "(S,S)-butanediol dehydrogenase activity", "d": ["Catalysis of the reaction: (S,S)-butane-2,3-diol + NAD+ = acetoin + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54747", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66142", "l": "CoA + H(+) + N-acetyloctopamine => acetyl-CoA + octopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64621", "l": "(E)-sinapyl alcohol + acetyl-CoA => (E)-sinapoyl actetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932020", "l": "GPAM gene expression is stimulated by RUNX1 and ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10509", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71862", "l": "glycochenodeoxycholate(out) <=> glycochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25314", "l": "glycolate + O2 <=> glyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696547", "l": "STAMBPL1 is a deubiquitinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362437", "l": "C-terminal Hh fragments are bound by lectins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59992", "l": "H(+) + oxidized [electron-transfer flavoprotein] + phloretate = (E)-4-coumarate + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63553", "l": "angiotensin-(1-7) + H2O => angiotensin-(1-5) + L-histidyl-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36765", "l": "beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32781", "l": "ADP + Co(2+)(in) + H(+) + phosphate => ATP + Co(2+)(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28359", "l": "FAD + H(+) + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56846", "l": "nocamycin I + S-adenosyl-L-homocysteine => nocamycin E + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913374", "l": "Phosphorylated SHC1 recruits SHIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209135", "l": "GISH further phosphorylates ARR in the receptor complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37297", "l": "ADP + H(+) + L-alanyl-L-threonine(in) + phosphate => ATP + H2O + L-alanyl-L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62037", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003942", "l": "N-acetyl-gamma-glutamyl-phosphate reductase activity", "d": ["Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75303", "l": "NAD(+) = 3'cADPR + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-174203", "l": "SCF-mediated degradation of Emi1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093331", "l": "Ras:GTP binds p120-RasGAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42444", "l": "L-aspartate + NADP(+) = H(+) + iminosuccinate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549355", "l": "CRY proteins stabilize unphosphorylated BMAL1:CLOCK,NPAS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28502", "l": "NAD(+) + S-(hydroxymethyl)mycothiol = H(+) + NADH + S-formylmycothiol", "d": []}, {"i": "EC:1.1.1.306", "l": "\"S-(hydroxymethyl)mycothiol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47820", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61490", "l": "5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(50) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49046", "l": "4-hydroxyprotoasukamycin + H2O + NAD(+) => H(+) + NADH + O2 + protoasukamycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668735", "l": "RAC1:GTP binds NOX3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68858", "l": "(E)-beta-farnesene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49282", "l": "catechol + FAD + H(+) + H2O => FADH2 + O2 + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59033", "l": "(Z)-24-ethylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50403", "l": "L-cysteinyl-[PqsC protein] + octanoyl-CoA <=> CoA + S-octanoyl-L-cysteinyl-[PqsC protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75574", "l": "acetyl-CoA + cyathin A3 <=> 11-O-acetylcyathin A3 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701064", "l": "TRPV1 binds TRPV1 agonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15382", "l": "O2 + quercetin => 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070402", "l": "NADPH binding", "d": ["Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018794", "l": "RHOV binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9795147", "l": "Apical excretion of sulfo-Cipro (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9691621", "l": "C5 binds C5 inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33044", "l": "(1R,4R)-camphor + H(+) + NADPH + O2 => (+)-6-exo-hydroxycamphor + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28076", "l": "(2R)-3-sulfolactate + 3 H(+) + 2 NADH => (2R)-3-sulfopropanediol + H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53610", "l": "(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+) => 4-hydroxyestrone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28692", "l": "(S)-dihydroorotate + a ubiquinone => a ubiquinol + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24162", "l": "D-galacto-hexodialdose + H2O2 => D-galactose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391158", "l": "SIRP alpha binds CD47 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981539", "l": "C3b binds to cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28884", "l": "H(+)(in) + L-threonine(in) => H(+)(out) + L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.222", "l": "\"4-hydroxytryptamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866269", "l": "ARRB bind GPCRs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030941", "l": "chloroplast targeting sequence binding", "d": ["Binding to a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51266", "l": "(10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424476", "l": "Activation of RAC1 by VAV2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54202", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654425", "l": "Activated FGFR4 binds SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193964", "l": "CYP21A2 21-hydroxylates PROG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111237", "l": "Formation of ADAR1 homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55777", "l": "all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate => all-trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674140", "l": "PAQR3 binds inactive RAFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75299", "l": "NAD(+) = 2'cADPR + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198983", "l": "NKG2D homodimer interacting with ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55649", "l": "2-oxoglutarate + O2 + validoxylamine A => CO2 + H(+) + succinate + validoxylamine B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018602", "l": "2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity", "d": ["Catalysis of the reaction: 2,4-dichlorophenoxyacetate + 2-oxoglutarate + oxygen = 2,4-dichlorophenol + glyoxylate + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62353", "l": "H(+) + NADPH + notoamide E + O2 => H2O + NADP(+) + notoamide D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29066", "l": "a menaquinone + formate + H(+) <=> a menaquinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24121", "l": "H(+) + leukotriene E4 + NADPH + O2 => 20-hydroxy-leukotriene E4 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14207", "l": "anserine + H(+) + S-adenosyl-L-homocysteine => carnosine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63543", "l": "H2O + neurotensin <=> L-leucine + neurotensin-(1-12)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44737", "l": "acetyl-CoA + dihydroxyacetone phosphate => 3-hydroxy-2,4-dioxopentyl phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909765", "l": "Mitochondrial uptake of beta-alanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50525", "l": "acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.98", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58422", "l": "3-methyl-2-butenal + H(+) + NADPH => NADP(+) + prenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166219", "l": "FA anion picks up a proton (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46650", "l": "androst-4-ene-3,17-dione + propanoyl-CoA => 17-hydroxy-3-oxochol-4-en-22-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48830", "l": "benzene-1,2,4-triol + H2O + NADP(+) => H(+) + NADPH + O2 + resorcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23432", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.52", "l": "\"(S)-limonene 7-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34565", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH => CDP-alpha-D-abequose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192123", "l": "CYP27A1 27-hydroxylates CHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20733", "l": "[protein]-dithiol + [thioredoxin]-disulfide => [protein]-disulfide + [thioredoxin]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849857", "l": "KLK5 cleaves and activates CELA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203567", "l": "palmitoylation of eNOS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77068", "l": "Activation of GT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426148", "l": "SREBP1A,1C binds the FASN promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11465", "l": "2 glutathione + L,L-homocystine => glutathione disulfide + 2 L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730847", "l": "Hydrolysis of PIP2 by PLCG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033856", "l": "pyridoxine 5'-phosphate synthase activity", "d": ["Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = 2 H2O + H+ + phosphate + pyridoxine 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782138", "l": "ERCC5 and RPA bind TC-NER site (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44444", "l": "a 1,2-diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937034", "l": "IRAK1 phosphorylates Pellino (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35836", "l": "2'-dehydrokanamycin A + H(+) + NADPH => kanamycin A + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615556", "l": "Defective POMT2 does not transfer Man from Dol-P-Man to DAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18693", "l": "a penicillin + H2O = 6-aminopenicillanate + a carboxylate", "d": []}, {"i": "EC:3.5.1.11", "l": "\"penicillin amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38465", "l": "a 1,2-diacyl-sn-glycerol + CoA => a 1-acyl-sn-glycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69541", "l": "GTP + streptomycin => 6-O-guanylylstreptomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55271", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate <=> (R)-glycerate + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21119", "l": "D-maltose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12575", "l": "(R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP <=> adenosylcob(III)inamide + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164832", "l": "ATPase synthesizes ATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592278", "l": "Autocatalytic activation of proMMP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19997", "l": "H2O + phosphoenolpyruvate = phosphate + pyruvate", "d": []}, {"i": "EC:3.1.3.60", "l": "\"phosphoenolpyruvate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011077", "l": "LHX2 binds to ROBO2 gene locus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9736953", "l": "FURIN translocates to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74275", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid A = a 2-acyl-sn-glycero-3-phosphocholine + a hepta-acyl lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12711", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31191", "l": "(3S)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39231", "l": "3-oxo-triacontanoyl-CoA + H(+) + NADPH = (3R)-hydroxytriacontanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21392", "l": "2-phenylacetaldehyde + H2O + NAD(+) = 2-phenylacetate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.39", "l": "\"phenylacetaldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109862", "l": "MAP2K2 phosphorylates MAPK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43752", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]", "d": []}, {"i": "EC:2.3.1.267", "l": "\"[ribosomal protein S5]-alanine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51647", "l": "cholesterol + H(+) + NADH + O2 <=> 7-dehydrocholesterol + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211948", "l": "CYP3A4 can N-demethylate loperamide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952232", "l": "BCL2L11 (BIM) gene transcription is stimulated by RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9619756", "l": "NR1H2 binds ABCA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52042", "l": "2-aminoprop-2-enoate + S-sulfanyl-L-cysteine => L-cystine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53320", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose = alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": []}, {"i": "EC:2.4.1.349", "l": "\"mannosyl-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.18", "l": "\"exo-alpha-sialidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72238", "l": "2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out) <=> 2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54619", "l": "2-oxoglutarate + heptadecanoyl-CoA + O2 <=> 2-hydroxyheptadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48522", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010308", "l": "acireductone dioxygenase (Ni2+-requiring) activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 3-(methylthio)propanoate + CO + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45218", "l": "Co(I)-[dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[dimethylamine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.839897517610368", "identifiers": [{"i": "GO:0016725", "l": "oxidoreductase activity, acting on CH or CH2 groups", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}, {"i": "EC:1.17.-.-", "l": "\"Acting on CH or CH2 groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17210", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O => 2-formylglutarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22176", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.94", "l": "\"leukotriene-B4 20-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52973", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] => a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013147", "l": "RAC1 GDIs block activation of RAC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32201", "l": "9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42569", "l": "2,3-dihydroxy-p-cumate + O2 => 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-419645", "l": "Dimerization of LIMK1 by Hsp90 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43212", "l": "adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.230", "l": "\"23S rRNA (adenosine(1067)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71882", "l": "2'-deoxyguanosine + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-2'-deoxyguanosine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874212", "l": "MBTPS1 (S1P) cleaves CREB3L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45044", "l": "2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2 = 2 Fe(III)-[cytochrome c] + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140483", "l": "kinetochore adaptor activity", "d": ["The binding activity of a protein that brings the kinetochore and another molecule into contact, permitting those molecules to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.44", "l": "\"nodavirus endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30157", "l": "FAD + 2 Fe(2+) + 3 H(+) => FADH2 + 2 Fe(3+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5675790", "l": "MTORC1 dissociates from ULK complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803240", "l": "Homo- or heterodimerization of RAF downstream of mutant RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66308", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose = an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32221", "l": "gamma-carotene => all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29486", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-beta-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781922", "l": "USP13 binds UFD1L:SKP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15531", "l": "2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+) => bis(2-ethylhexyl)phthalate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54144", "l": "2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 = 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5627775", "l": "Autophosphorylation of PAK1,2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53268", "l": "L-ribulose = L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34881", "l": "4-methoxy-4-oxo-3-phenylbutanoate + NH4(+) => 2 H2O + methyl 3-cyano-2-phenylpropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633295", "l": "TP53 binds the NDRG1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44802", "l": "2-demethylmenaquinol-6 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034875", "l": "caffeine oxidase activity", "d": ["Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62050", "l": "an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17098", "l": "3-phenylpyruvate => enol-phenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985485", "l": "RUNX2 and RB1 bind the BGLAP gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32282", "l": "allantoate + 2 H(+) + 2 H2O <=> (S)-ureidoglycolate + CO2 + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000007", "l": "low-affinity zinc ion transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656070", "l": "FGFBPs bind FGFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0097245", "l": "flavanol binding", "d": ["Binding to a flavanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19790", "l": "4-(dimethylamino)azobenzene + H2O + NADP(+) => 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71984", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + fusoxypene B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3828025", "l": "DCN (decorin) degradation by MMP14 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54678", "l": "(+)-kolavenyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54669", "l": "pre-alpha-onocerin => alpha-onocerin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253343", "l": "WWOX binds ERBB4s80 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75550", "l": "2 (3R)-3-isocyanylbutanoyl-[ACP] + ATP + L-lysine + 2 NADPH <=> (2S)-2,6-bis[(3R)-3-isocyanobutanamido]hexan-1-ol + AMP + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30448", "l": "3-methylxanthine + H(+) + NADH + O2 => formaldehyde + H2O + NAD(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60151", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate <=> (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013438", "l": "RHOD binds effectors at the endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3204303", "l": "MRE11 binds cytosolic DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22463", "l": "a 2,3-saturated acyl-CoA + NADP(+) <=> a 2,3-dehydroacyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10489", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP => 5,10-methenyltetrahydrofolate + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14093", "l": "2-oxoglutarate + L-tryptophan = indole-3-pyruvate + L-glutamate", "d": []}, {"i": "EC:2.6.1.27", "l": "\"tryptophan transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806974", "l": "MET dimers autophosphorylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18588", "l": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75777", "l": "(10S)-hydroxy-(6Z,12Z)-octadecadienoate => (6Z,9Z,12Z)-octadecatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607746", "l": "PKC-delta is activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396393", "l": "NOTCH1 PEST domain mutants bind MYC promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62987", "l": "H2O + hexadecanamide <=> hexadecanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034211", "l": "GTP-dependent protein kinase activity", "d": ["GTP dependent catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0009013", "l": "succinate-semialdehyde dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57327", "l": "acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] <=> CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59183", "l": "5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O <=> 2 AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74734", "l": "Re-integration of insulin receptor into plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58918", "l": "(S)-2,3-epoxysqualene + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64972", "l": "dUDP + H2O = dUMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10096", "l": "a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.3.1.184", "l": "\"acyl-homoserine-lactone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32114", "l": "S-adenosyl-L-methionine + trans-resveratrol <=> 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016996", "l": "endo-alpha-(2,8)-sialidase activity", "d": ["Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77068", "l": "Activation of GT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32025", "l": "avermitilol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653724", "l": "Transcription of ATF5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63701", "l": "mycophenolate + UDP-alpha-D-glucuronate => mycophenolic acid O-acyl-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12722", "l": "putrescine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + S-methyl-5'-thioadenosine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158313", "l": "factor XII -> factor XIIa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16306", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O => 3-hydroxy-3-methylglutarate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75081", "l": "Formation of AT-AC B Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25474", "l": "diphosphate + gamma-himachalene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632182", "l": "PRMT1 methylates ESRs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35260", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64342", "l": "4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + diphosphate => (2E,6E)-farnesyl diphosphate + 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56299", "l": "2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein] <=> pyruvate + S-sulfanyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38630", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA <=> 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13006", "l": "(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine => H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036012", "l": "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (c branch) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31746", "l": "a 4'-hydroxyflavanone + S-adenosyl-L-methionine <=> a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58978", "l": "3-oxopropanoate + H(+) + H2O2 => H2O + malonaldehyde + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451309", "l": "Edited Kainate Receptor binds glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050197", "l": "phytanate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H+ + phytanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34635", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 = H2O + NADP(+) + pentalenolactone D", "d": []}, {"i": "EC:1.14.13.170", "l": "\"pentalenolactone D synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-398040", "l": "Gbeta:gamma activation of PLC beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030272", "l": "5-formyltetrahydrofolate cyclo-ligase activity", "d": ["Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033416", "l": "UGG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UGG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39542", "l": "(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH <=> (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803063", "l": "RNASEs bind bacterial LPS, PGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983156", "l": "Polyubiquitination of substrate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170978", "l": "p-FRS2:CRKL binds C3G (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30890", "l": "4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin <=> 7,8-dihydropteroate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416516", "l": "GRK2 sequesters activated Gq (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2396395", "l": "HSPG2 (perlecan) binds alpha-dystroglycan (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59383", "l": "4-amino-4-deoxyprephenate + NAD(+) <=> 3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474210", "l": "Collagen type III degradation by MMP14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034768", "l": "(E)-beta-ocimene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = (E)-beta-ocimene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2314686", "l": "ASA- acetylates PTGS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769394", "l": "AKT phosphorylates CBY1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19504", "l": "4-guanidinobutanoate + H2O <=> 4-aminobutanoate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937989", "l": "RUNX1 binds PRC1 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44593", "l": "3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008531", "l": "riboflavin kinase activity", "d": ["Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40090", "l": "22-hydroxydocosanoate + NAD(+) <=> 22-oxodocosanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48119", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50134", "l": "ethanol + H(+) + hexadecanoate => ethyl hexadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69419", "l": "H(+) + H2O2 + thiocyanate <=> H2O + hypothiocyanous acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694522", "l": "Inner coat assembly and cargo binding (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5655483", "l": "USP1 autocleavage (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70822", "l": "L-homoarginine(in) + L-ornithine(out) <=> L-homoarginine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37677", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450187", "l": "TAK1 is activated within the TAK1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52971", "l": "hyocholate + UDP-alpha-D-glucuronate <=> H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72533", "l": "ADP + H(+) + methyl beta-D-galactoside(in) + phosphate => ATP + H2O + methyl beta-D-galactoside(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37540", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769394", "l": "AKT phosphorylates CBY1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72722", "l": "eIF2 activation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29014", "l": "2-oxoglutarate(in) + H(+)(in) <=> 2-oxoglutarate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65723", "l": "2-oxoglutarate + butyl sulfate + O2 <=> butanal + CO2 + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24354", "l": "ethyl 3-oxohexanoate + H(+) + NADPH => ethyl (R)-3-hydroxyhexanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31640", "l": "mycinamicin III + S-adenosyl-L-methionine => H(+) + mycinamicin IV + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14742", "l": "4-methylene-L-glutamine + H2O => 4-methylene-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47089", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) => 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050291", "l": "sphingosine N-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676589", "l": "RANKL,sRANKL trimer binds RANK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203613", "l": "depalmitoylation of eNOS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350578", "l": "NQO1 interaction with ODC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47278", "l": "15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785898", "l": "IL4R binds JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15314", "l": "ethanolamine => acetaldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432143", "l": "PECAM-1 binds PP2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247847", "l": "WLS is endocytosed to the early endosome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73218", "l": "sulfate(out) + thiosulfate(in) <=> sulfate(in) + thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62174", "l": "an N-acylethanolamine + phosphate => an N-acylethanolamine phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008566", "l": "mitochondrial protein-transporting ATPase activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49758", "l": "CO2 + H2O + proviolacein => H(+) + O2 + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012082", "l": "Autocatalytic phosphorylation of FGFR3 cysteine mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295622", "l": "SPRY2 binds CBL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6805981", "l": "HMGB1 release from cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65171", "l": "AH2 + O2 + preaustinoid A <=> A + H2O + preaustinoid A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69134", "l": "5-aminopentanal + H2O2 + NH4(+) => cadaverine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.863640214551324", "identifiers": [{"i": "GO:0004096", "l": "catalase activity", "d": ["Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63994", "l": "5-fluorocytidine 5'-phosphate + ADP + H(+) => 5-fluorocytidine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37693", "l": "1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17378", "l": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] => 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74022", "l": "glycine(out) + L-alanine(in) <=> glycine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68079", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP <=> a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20327", "l": "N-acetoxy-4-aminobiphenyl => N-hydroxy-4-acetylaminobiphenyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.12", "l": "\"carboxypeptidase M\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65413", "l": "dAMP(in) + NAD(+)(out) => dAMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47927", "l": "2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate <=> (2S)-3-sulfolactaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56120", "l": "2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694665", "l": "SARS-CoV-2 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14222", "l": "H2O + monomethyl sulfate => H(+) + methanol + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19239", "l": "4-carboxymethyl-3-methylbut-2-en-1,4-olide => 4-carboxymethyl-4-methylbut-2-en-1,4-olide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64920", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44898", "l": "H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP => a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10867", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 <=> 2-(acetamidomethylene)succinate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220944", "l": "ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73249", "l": "H(+) + S-adenosyl-L-homocysteine + salvigenin => ladanein + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25264", "l": "2-hydroxyglutarate + FAD + H(+) <=> 2-oxoglutarate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853792", "l": "RET tyrosine phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50136", "l": "ethyl (9Z)-octadecenoate + H2O = (9Z)-octadecenoate + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902387", "l": "ceramide 1-phosphate binding", "d": ["Binding to ceramide 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44279", "l": "eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784861", "l": "HSPG binds LPL dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16749", "l": "H2O + phosphonoacetate = acetate + H(+) + phosphate", "d": []}, {"i": "EC:3.11.1.2", "l": "\"phosphonoacetate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24870", "l": "5'-deoxyadenosine + phosphate => 5-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666008", "l": "SCAI binds SRF:MKL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18977", "l": "a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201717", "l": "CSNK2-mediated phosphorylation of DVL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42533", "l": "uridine(55) in tRNA => pseudouridine(55) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25259", "l": "N-acetyl-D-mannosamine 6-phosphate => N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44266", "l": "4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA => eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034949", "l": "1,1-dichloroethane reductive dehalogenase activity", "d": ["Catalysis of the reaction: 1,1-dichloroethane + 2 H+ + 2 e- = chloroethane + HCl."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9794523", "l": "SLC22A1 transports Cipro into renal cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416698", "l": "SEMA5A binds to PLXNB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692809", "l": "CDC42 binds effectors at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60686", "l": "(11R)-dihydroartemisinate + 2 H(+) + NADPH => (11R)-dihydroartemisinic aldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47538", "l": "isochenodeoxycholate + NADP(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168376", "l": "STIM1 oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15137", "l": "galactitol 1-phosphate + NAD(+) = H(+) + keto-L-tagatose 6-phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39131", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54784", "l": "Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}, {"i": "EC:4.99.1.12", "l": "\"pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel chelatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374662", "l": "Translocation of Ezrin to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173542", "l": "SMURF2 ubiquitinates SMAD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013024", "l": "RHOB binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.14", "l": "\"2-hydroxy-6-oxonona-2,4-dienedioate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36395", "l": "7-dehydrocholesterol + NADP(+) = 7-dehydrodesmosterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39603", "l": "(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA = (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47507", "l": "chenodeoxycholate + NADP(+) <=> 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15813", "l": "1H-imidazole + acetyl-CoA = CoA + N-acetylimidazole", "d": []}, {"i": "EC:2.3.1.2", "l": "\"imidazole N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201608", "l": "Caspase-mediated cleavage of alpha adducin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033830", "l": "Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetylglucosamine + Skp1-protein-hydroxyproline = UDP + Skp1-protein-O-(N-acetyl-D-glucosaminyl)hydroxyproline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14613", "l": "ATP + H2O + taurine(out) = ADP + H(+) + phosphate + taurine(in)", "d": []}, {"i": "EC:7.6.2.7", "l": "\"ABC-type taurine transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5681987", "l": "LC3 is cleaved by ATG4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2203480", "l": "COLEC11 binds ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73154", "l": "CoA(out) + FMN(in) <=> CoA(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080098", "l": "L-tyrosine:pyruvate aminotransferase activity", "d": ["Catalysis of the reaction: L-tyrosine + pyruvate = (4-hydroxyphenyl)pyruvate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17035", "l": "biphenyl-2,3-diol + H(+) + NADH => (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64247", "l": "a fatty acyl-CoA + glycine <=> an N-(fatty acyl)-glycine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58492", "l": "ATP + Fe(III)-enterobactin(out) + H2O = ADP + Fe(III)-enterobactin(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.2.2.17", "l": "\"ABC-type ferric enterobactin transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.258", "l": "\"N-terminal methionine N(alpha)-acetyltransferase NatE\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57211", "l": "glyoxal + L-cysteinyl-[protein] <=> S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54697", "l": "4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase] => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9718379", "l": "GNRHR binds chemical antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54383", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 5-hydroxy-alpha-gurjunene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632738", "l": "DDIT4 binds 14-3-3 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14765", "l": "coelenterazine h + O2 = CO2 + excited coelenteramide h monoanion + H(+) + hnu", "d": []}, {"i": "EC:1.13.12.5", "l": "\"Renilla-type luciferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0016826", "l": "hydrolase activity, acting on acid sulfur-nitrogen bonds", "d": ["Catalysis of the hydrolysis of any acid sulfur-nitrogen bond."]}, {"i": "EC:3.10.-.-", "l": "\"Acting on sulfur-nitrogen bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65496", "l": "3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH = 3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28259", "l": "cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate => cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380930", "l": "Phosphorylated AMPK binds AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59773", "l": "D-sorbitol + O2 => D-sorbopyranose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31941", "l": "DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29436", "l": "enterobactin(in) + H(+)(out) => enterobactin(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196964", "l": "RFK:Mg2+ phosphorylates RIB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40470", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9681294", "l": "IL6R binds IL6R inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199144", "l": "Nectin 2 binds CD226 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0042132", "l": "fructose 1,6-bisphosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8963851", "l": "VD3 dissociates from GC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55511", "l": "cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173542", "l": "SMURF2 ubiquitinates SMAD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849882", "l": "SALMs 1-4 bind reticulon 3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36312", "l": "3,4-dihydroxybenzaldehyde + H2O + NAD(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19859", "l": "a 16-oxosteroid + H(+) + NADPH => a 16alpha-hydroxysteroid + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705584", "l": "HMGCR dimer binds statins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050024", "l": "L-galactonolactone oxidase activity", "d": ["Catalysis of the reaction: L-galactono-1,4-lactone + O2 = L-ascorbate + H2O2 + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106331", "l": "sialate 4-O-acetylesterase activity", "d": ["Catalysis of the reaction: H2O + N-acetyl-4-O-acetylneuraminate = acetate + H+ + N-acetylneuraminate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68431", "l": "lutein + O2 <=> (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R,6R)-hydroxy-alpha-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74333", "l": "O-butanoyl-(R)-carnitine(out) => O-butanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11249", "l": "[(3R)-hydroxybutanoate](n) + H2O => (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32076", "l": "geranylgeranyl diphosphate + H2O => (13E)-labda-7,13-dien-15-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419843", "l": "CALCA(83-119) binds CALCR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55695", "l": "an inositol-1-phosphoceramide + H2O <=> 1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45565", "l": "2-epi-5-epi-valiolone => 5-epi-valiolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12877", "l": "acetylacetone + O2 = acetate + H(+) + methylglyoxal", "d": []}, {"i": "EC:1.13.11.50", "l": "\"acetylacetone-cleaving enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018025", "l": "calmodulin-lysine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570528", "l": "SUMOylation of XPC with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54094", "l": "2,4,5-trihydroxyphenylacetate + H2O + NADP(+) => 3,4-dihydroxyphenylacetate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684321", "l": "nsp3 cleaves nsp1-4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731931", "l": "EDNRA binds selective ERAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52835", "l": "1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9656893", "l": "OPN1MW binds 11cRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43709", "l": "ATP + H(+) + hexadecanoate => diphosphate + hexadecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73048", "l": "guanidinoacetate(in) => guanidinoacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004830", "l": "tryptophan-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16973", "l": "2-hydroxypyridine + AH2 + O2 = 2,5-dihydroxypyridine + A + H2O", "d": []}, {"i": "EC:1.14.99.26", "l": "\"2-hydroxypyridine 5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.4.4", "l": "\"[ribosomal protein S12] (aspartate(89)-C(3))-methylthiotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53521", "l": "1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33787", "l": "3'-ketolactose + H2O = 3-keto-beta-D-galactose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56176", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O = 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043995", "l": "histone H4K5 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5)."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0010854", "l": "adenylate cyclase regulator activity", "d": ["Binds to and modulates the activity of adenylate cyclase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44437", "l": "a 1,2-diacylglycerol + a 1-acylglycerol => a triacylglycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351876", "l": "Caspase-mediated cleavage of occludin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444100", "l": "PROT mediates L-proline uptake (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2529020", "l": "CK2 phosphorylates condensin I subunits (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008577", "l": "IL37:IL18R1 binds SIGIRR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66418", "l": "ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58924", "l": "(3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol = (-)-maackiain + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12624", "l": "H(+) + L-aspartate <=> CO2 + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23148", "l": "ATP + propanoate = ADP + propanoyl phosphate", "d": []}, {"i": "EC:2.7.2.15", "l": "\"propionate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25505", "l": "(2E)-geranyl diphosphate => beta-phellandrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40821", "l": "(9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031738", "l": "XCR1 chemokine receptor binding", "d": ["Binding to a XCR1 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71781", "l": "4-methyl-2-oxopentanoate(in) + H(+)(in) => 4-methyl-2-oxopentanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203553", "l": "eNOS binds NOSIP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.843050782660015", "identifiers": [{"i": "GO:0019865", "l": "immunoglobulin binding", "d": ["Binding to an immunoglobulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299318", "l": "Activation of TASK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090560", "l": "2-(3-amino-3-carboxypropyl)histidine synthase activity", "d": ["Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48172", "l": "ganglioside GM2 + H2O = N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0010461", "l": "light-activated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of a monoatomic ion by a channel that opens in response to a light stimulus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34750", "l": "15-methylhexadecasphinganine + ATP <=> 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032863", "l": "CDK5 phosphorylates NTRK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166015", "l": "Association of LBP with LPS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12805", "l": "(S)-canadine + S-adenosyl-L-methionine = (S)-cis-N-methylcanadine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.122", "l": "\"(S)-tetrahydroprotoberberine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44195", "l": "2-methylhexadecanoate + ATP + CoA <=> 2-methylhexadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757448", "l": "ST translocates from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161282", "l": "Elastic fibres bind associated proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19716", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034937", "l": "perchlorate reductase activity", "d": ["Catalysis of the reaction: perchlorate + 2 H+ + 2 e- = chlorate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19598", "l": "H2O + L-arginine => L-citrulline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200646", "l": "Cytosolic folate export across the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57846", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form) => fraxetin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875558", "l": "RAPGEF1 binds CRK,CRKL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72569", "l": "dehydroepiandrosterone 3-sulfate(out) + propanoate(in) => dehydroepiandrosterone 3-sulfate(in) + propanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954082", "l": "E2F6 binds the PRC1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70746", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680812", "l": "nsp7 binds nsp8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951926", "l": "RUNX1 gene expression is inhibited by RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9648268", "l": "HTR1A binds HTR1A antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.68", "l": "\"Ulp1 peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863718", "l": "AGFG1 binds VAMP7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169402", "l": "ISGylation of E2 conjugating enzymes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42854", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine => 3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40285", "l": "CoA + O-hexadecanedioyl-L-carnitine => (R)-carnitine + hexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64571", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one <=> ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47663", "l": "acetyl-CoA + L-methionine sulfoximine <=> CoA + H(+) + N-acetyl-L-methionine sulfoximine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375160", "l": "NCAM1 binds to ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4167511", "l": "HLCS biotinylates ACACB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61396", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181351", "l": "LEFTY binds the EGF-CFC coreceptor in the NODAL receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141671", "l": "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2106615", "l": "Removal of siRNA passenger strand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38552", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoate + O2 => (R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399982", "l": "AKT1 E17K mutant phosphorylates TSC2, inhibiting it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8963915", "l": "1,25(OH)2D binds VDR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27529", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (2E,6E)-farnesol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149433", "l": "Synthesis of VPU protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0072341", "l": "modified amino acid binding", "d": ["Binding to a modified amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35781", "l": "mutildienyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55724", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030603", "l": "oxaloacetase activity", "d": ["Catalysis of the reaction: H2O + oxaloacetate = acetate + H+ + oxalate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33556", "l": "an N-acyl-(4R)-4-hydroxysphinganine + H2O => (4R)-hydroxysphinganine + a fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41421", "l": "2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 => CO2 + grixazone B + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36105", "l": "O-methyl anthranilate + S-adenosyl-L-homocysteine => anthranilate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18874", "l": "3-chloro-D-alanine + H2O => chloride + H(+) + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9706393", "l": "RHOBTB3 binds ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63804", "l": "GDP-beta-L-gulose = GDP-beta-L-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32594", "l": "(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O <=> (3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665761", "l": "FMNL3 binds RHOC:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173723", "l": "C8 binds C5b:C6:C7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22054", "l": "AH2 + H(+) + hydroxylamine => A + H2O + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090564", "l": "protein-phosphocysteine-glucose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucose(out) = protein cysteine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0034458", "l": "3'-5' RNA helicase activity", "d": ["Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22862", "l": "deamido-NAD(+) + diphosphate => ATP + H(+) + nicotinate beta-D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23654", "l": "N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+) => N-terminal L-glutaminyl-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38725", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52138", "l": "a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+) => a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114284", "l": "Release of Cytochrome c from mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9669854", "l": "KIT binds type II TKIs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72021", "l": "2 CO2 + H2O + succinate + trihazone D => 2-oxoglutarate + H(+) + O2 + trihazone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16655", "l": "2-dehydro-D-gluconate + H(+) + NADPH => D-gluconate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.13", "l": "\"gamma-D-glutamyl-L-lysine dipeptidyl-peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52212", "l": "acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875013", "l": "ACSM3,ACSM6 ligate CoA to BUT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77609", "l": "Binding of APOBEC-1 to form editosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007901", "l": "IL1F10 binds IL1RL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56971", "l": "dCTP + pyruvate <=> dCDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299338", "l": "Activation of TRESK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013158", "l": "CDC42 GDIs block activation of CDC42 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130349", "l": "Generation of CLIP from lip10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664867", "l": "NBR1 binds MAP1LC3B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75114", "l": "32-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39644", "l": "(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH => (18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61947", "l": "24-methylenecholesterol + UDP-alpha-D-glucose <=> 24-methylene cholesteryl beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33940", "l": "H(+) + L-arginine + NADH + O2 => H2O + N(omega)-hydroxy-L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350604", "l": "Agmatine + H2O <=> putrescine + urea (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675431", "l": "PP2A dephosphorylates RAF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204861", "l": "Interaction of Tie2 and Shc1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44708", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798138", "l": "TP53 binds the CASP10 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674022", "l": "BRAP autoubiquitinates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11877", "l": "NAD(+) + prostaglandin E2 => 15-oxoprostaglandin E2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034569", "l": "monodemethylisoproturon dehydrogenase activity", "d": ["Catalysis of the reaction: monodemethylisoproturon + H2O = hydroxymonodemethylisoproturon + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760652", "l": "ILF3 binds CDH11 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61936", "l": "ATP + cycloheximide(in) + H2O = ADP + cycloheximide(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806957", "l": "MET receptor dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19123", "l": "ADP + an S-substituted glutathione(out) + H(+) + phosphate => an S-substituted glutathione(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64530", "l": "2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine => AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11989", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine => 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55488", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15928", "l": "dihydrobunolol + NADP(+) <=> bunolol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047249", "l": "sarsapogenin 3-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: (25S)-5beta-spirostan-3beta-ol + UDP-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332235", "l": "CBL binds TGFBR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12851", "l": "L-seryl-[myosin light chain] + phosphate => H2O + O-phospho-L-seryl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25501", "l": "(2E)-geranyl diphosphate => diphosphate + terpinolene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.5", "l": "\"type III site-specific deoxyribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.461014234140904", "identifiers": [{"i": "GO:1901618", "l": "organic hydroxy compound transmembrane transporter activity", "d": ["Enables the transfer of organic hydroxy compound from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "58.921322376698093", "identifiers": [{"i": "GO:0008168", "l": "methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109701", "l": "PDPK1 binds PIP3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31667", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": []}, {"i": "EC:2.6.1.89", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016697", "l": "oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces a cytochrome."]}, {"i": "EC:1.12.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33768", "l": "a 3-hydroxy-fatty acyl-CoA => a (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12557", "l": "6-phospho-D-glucono-1,5-lactone + H2O => 6-phospho-D-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56608", "l": "5,10-methylenetetrahydrosulfopterin + glycine + H2O = L-serine + tetrahydrosulfopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39279", "l": "ATP + dodecanoate(out) + H2O = ADP + dodecanoate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129353", "l": "Tropoelastin associates with microfibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086062", "l": "voltage-gated sodium channel activity involved in Purkinje myocyte action potential", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69345", "l": "(E)-but-1-en-1-SO-peroxol => (Z)-butanethial oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654404", "l": "Activated FGFR2 binds SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2471621", "l": "Endostatin degradation by cathepsins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56285", "l": "a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) => a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850797", "l": "SPINK6 binds KLK13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.186", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58570", "l": "CoA + O-acetyl-15alpha-stemmadenine => 15alpha-stemmadenine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31262", "l": "but-3-ynal + H2O + NAD(+) <=> 3-butynoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41508", "l": "L-ornithine + NADPH + O2 = H2O + N(5)-hydroxy-L-ornithine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982617", "l": "CYGB:O2 dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74423", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69079", "l": "(R)-noradrenaline + H2O + O2 <=> (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24674", "l": "ATP + cytidine = ADP + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044019", "l": "histone H3K72 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 72) = CoA + histone H3 N6-acetyl-L-lysine (position 72)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696958", "l": "USP44 deubiquitinates CDC20 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362427", "l": "Hh-Np binds GPC5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.37", "l": "\"leukocyte elastase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018652", "l": "toluene-sulfonate methyl-monooxygenase activity", "d": ["Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- + 4-sulfobenzyl alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32413", "l": "(1R,4S)-isodihydrocarvone + H(+) + NADH => (1R,2R,4S)-isodihydrocarveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848864", "l": "PTK6 binds ARAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.2", "l": "\"Aspergillus deoxyribonuclease K1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71285", "l": "chloride(in) + L-glutamine(in) + 2 Na(+)(in) => chloride(out) + L-glutamine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987214", "l": "p-STAT3 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016490", "l": "structural constituent of peritrophic membrane", "d": ["The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents. An example of this is found in Drosophila melanogaster."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691154", "l": "HFE binds TFRC dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34262", "l": "(+)-larreatricin + AH2 + O2 <=> (+)-3'-hydroxylarreatricin + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72865", "l": "G[3'-5']pA[3'-5']pAp[3'] + H(+) => 3',3',3'-cAAG + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865482", "l": "KMT2A (MLL) binds RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57661", "l": "(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34275", "l": "2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine = 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine", "d": []}, {"i": "EC:1.1.99.38", "l": "\"2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40900", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042878", "l": "D-glucarate transmembrane transporter activity", "d": ["Enables the transfer of D-glucarate, the D-enantiomer of glucarate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362549", "l": "Hh-Np traffics to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047673", "l": "anthranilate N-malonyltransferase activity", "d": ["Catalysis of the reaction: anthranilate + malonyl-CoA = N-malonylanthranilate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44795", "l": "2-demethylmenaquinol-12 + S-adenosyl-L-methionine <=> H(+) + menaquinol-12 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13425", "l": "a pyrimidine ribonucleoside 5'-phosphate + H2O = a pyrimidine nucleobase + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72103", "l": "Formation of pre-mRNPs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.353", "l": "\"versiconal hemiacetal acetate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53085", "l": "[(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20704", "l": "a D-alpha-amino acid + acetyl-CoA = an N-acetyl-D-amino acid + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.36", "l": "\"D-amino-acid N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19697", "l": "11-cis-retinyl hexadecanoate + H2O = 11-cis-retinol + H(+) + hexadecanoate", "d": []}, {"i": "EC:3.1.1.63", "l": "\"11-cis-retinyl-palmitate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27732", "l": "beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602984", "l": "Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419351", "l": "PAF receptor binds platelet activating factor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46626", "l": "a L-5-monosubstituted hydantoin => a D-5-monosubstituted hydantoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68787", "l": "(2Z,6Z)-farnesyl diphosphate <=> diphosphate + gamma-curcumene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16531", "l": "adenosine 5'-phosphosulfate + phosphate => ADP + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380782", "l": "STAT binds to the active receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44241", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956639", "l": "RUNX1 binds YAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665707", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52881", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate => 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018817", "l": "2-oxo-hept-3-ene-1,7-dioate hydratase activity", "d": ["Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942302", "l": "MMP13 cleaves OPTC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332236", "l": "CBL neddylates TGFBR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48758", "l": "D-erythrulose + H(+) + NADH => erythritol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31379", "l": "H2O + pyrrole-2-carboxylate = 1H-pyrrole + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035987", "l": "Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868344", "l": "CDK5:p25 phosphorylates lamin A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64207", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65213", "l": "(2E)-dodecenoyl-CoA + H2O => (2E)-dodecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050163", "l": "oxaloacetate tautomerase activity", "d": ["Catalysis of the reaction: oxaloacetate = <stereo>enol</stereo>-oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.3", "l": "\"D-amino-acid oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73017", "l": "D-leucine(out) => D-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102952", "l": "UDP-glucose:coniferaldehyde 4-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + coniferyl aldehyde = H+ + coniferaldehyde glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2002440", "l": "Removal of fibrillar collagen C-propeptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362422", "l": "Hh-Np binds to DISP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685011", "l": "ATR activation at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28749", "l": "NH4(+)(out) => NH4(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33530", "l": "acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol <=> CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66070", "l": "H2O + kynurenate + L-leucine => 4-methyl-2-oxopentanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664850", "l": "ATM binds PEX5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32529", "l": "N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine => N,N'-diacetylchitobiose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41522", "l": "H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase] => menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018807", "l": "RAC3 GDIs block activation of RAC3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35867", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37438", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate <=> a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40992", "l": "(E)-4-coumaroyl-CoA + H2O => 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10927", "l": "cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide <=> trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19202", "l": "2'-deoxyguanosine + ATP => ADP + dGMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034546", "l": "2,4-dichloroaniline reductive dehalogenase activity", "d": ["Catalysis of the reaction: 2,4-dichloroaniline + 2 H+ + 2 e- = 4-chloroaniline + HCl."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050322", "l": "taurine-2-oxoglutarate transaminase activity", "d": ["Catalysis of the reaction: taurine + 2-oxoglutarate = sulfoacetaldehyde + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022911", "l": "CSPG is secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44469", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33073", "l": "2-deoxy-L-scyllo-inosose + phosphate => D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69274", "l": "allyl isothiocyanate + sulfate => (Z)-N-(sulfonatooxy)prop-2-enimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69617", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033748", "l": "hydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: H2 + A = AH2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977301", "l": "Histidine is decarboxylated to histamine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647631", "l": "GSDMD (1-275) binds PIPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49345", "l": "2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70437", "l": "a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030107", "l": "HLA-A specific inhibitory MHC class I receptor activity", "d": ["Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21408", "l": "H2O + L-phenylalanine + NAD(+) = 3-phenylpyruvate + H(+) + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.20", "l": "\"phenylalanine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047362", "l": "thiosulfate-dithiol sulfurtransferase activity", "d": ["Catalysis of the reaction: dithioerythritol + thiosulfate = hydrogen sulfide + dithioerythritol disulfide + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64863", "l": "(E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine <=> (E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25960", "l": "benzoin + NADP(+) = benzil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51464", "l": "deoxycholate + O2 + reduced [NADPH--hemoprotein reductase] = 1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106429", "l": "11-cis-retinol dehydrogenase", "d": ["Catalysis of the reaction:11-cis-retinol-[retinal-binding-protein] + NAD+ <=> 11-cis-retinal-[retinol-binding-protein] + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65703", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] <=> cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22181", "l": "(S)-norreticuline + S-adenosyl-L-methionine => (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008138", "l": "protein tyrosine/serine/threonine phosphatase activity", "d": ["Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017124", "l": "SH3 domain binding", "d": ["Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43582", "l": "AH2 + iminoarginine => A + D-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0008169", "l": "C-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015094", "l": "lead ion transmembrane transporter activity", "d": ["Enables the transfer of lead (Pb) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388596", "l": "Melanocortin receptors bind melanocortins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351876", "l": "Caspase-mediated cleavage of occludin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.8", "l": "\"Delta(3)-Delta(2)-enoyl-CoA isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68851", "l": "(2Z,6E)-farnesyl diphosphate <=> diphosphate + gamma-cadinene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007816", "l": "RUNX2 binds HAND2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22768", "l": "4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one", "d": []}, {"i": "EC:4.3.3.1", "l": "\"3-ketovalidoxylamine C-N-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857686", "l": "FITM1, FITM2 bind TAGs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950732", "l": "Expression of Macrophage migration inhibitory factor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174171", "l": "Association of Cyclin A with the APC/C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047950", "l": "glutathione oxidase activity", "d": ["Catalysis of the reaction: 2 glutathione + O2 = glutathione disulfide + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.139", "l": "\"umbelliferone 6-dimethylallyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13017", "l": "diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil", "d": []}, {"i": "EC:2.4.2.9", "l": "\"uracil phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47118", "l": "H2O + N-eicosanoylglycinate => eicosanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49922", "l": "(R)-carnitine(in) + O-octanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-octanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.154", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68525", "l": "(2Z,6Z)-farnesyl diphosphate => beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66420", "l": "ATP + glutathione(in) + H2O + tauroursodeoxycholate(in) = ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13743", "l": "indole-3-pyruvate + L-phenylalanine => 3-phenylpyruvate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52390", "l": "4-O-phospho-D-threonate + ADP + H(+) => ATP + D-threonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60064", "l": "a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102637", "l": "5-aminolevulinate-CoA ligase activity", "d": ["Catalysis of the reaction: 5-ammoniolevulinate + coenzyme A + ATP <=> 5-aminolevulinyl-CoA + AMP + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18292", "l": "(S,S)-tartrate <=> H2O + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047886", "l": "farnesol dehydrogenase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP+ = 2-trans,6-trans-farnesal + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031955", "l": "short-chain fatty acid-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + a short-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. A short-chain fatty acid is a fatty acid with an aliphatic tail of less than 6 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75531", "l": "AH2 + N-acetyl-S-hydroxy-L-cysteine = A + H2O + N-acetyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.119", "l": "\"kallikrein 13\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12536", "l": "H(+) + L-arogenate = CO2 + H2O + L-phenylalanine", "d": []}, {"i": "EC:4.2.1.91", "l": "\"arogenate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34760", "l": "ATP + glycerol 2-phosphate(out) + H2O => ADP + glycerol 2-phosphate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905055", "l": "calcium:monoatomic cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration", "d": ["Any calcium:cation antiporter activity that is involved in regulation of presynaptic cytosolic calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69219", "l": "(omega-1)-methyl-(3R)-hydroxy-fatty acyl-CoA + NADP(+) <=> (omega-1)-methyl-3-oxo-fatty acyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55691", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O <=> 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867613", "l": "PICALM binds R-SNAREs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69679", "l": "apigenin 7-O-beta-D-glucoside + H2O = apigenin + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661419", "l": "ALB binds extracellular heme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12335", "l": "ATP + Fe(3+)(out) + H2O <=> ADP + Fe(3+)(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.39", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168640", "l": "Ubiquitinated IkB is degraded (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645598", "l": "RRAGC,D hydrolyzes GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114553", "l": "Activation of conventional Protein Kinase C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11216", "l": "a 2'-deoxyribonucleoside 5'-phosphate + ATP = a 2'-deoxyribonucleoside 5'-diphosphate + ADP", "d": []}, {"i": "EC:2.7.4.13", "l": "\"(deoxy)nucleoside-phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-452091", "l": "Phosphorylation of IL2RB Y338 enables SHC recruitment (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48418", "l": "CMP + ganglioside GM2 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32432", "l": "(1R,4S)-menthone + H(+) + NADPH + O2 => (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67816", "l": "a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.-", "l": "\"With H2O2 as acceptor, one oxygen atom of which is incorporated into the product\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45280", "l": "12-(phosphooxy)octadecanoate + H2O = 12-hydroxyoctadecanoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-167415", "l": "G-protein alpha subunit is inactivated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70391", "l": "3-oxosphinganine + eicosanoyl-CoA = CoA + H(+) + N-eicosanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264622", "l": "Cho is acetylated to AcCho by CHAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018776", "l": "trans-chloroacrylic acid dehalogenase activity", "d": ["Catalysis of the reaction: trans-3-chloroacrylic acid + H2O = H+ + malonate semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15829", "l": "a 16alpha-hydroxysteroid = a 16beta-hydroxysteroid", "d": []}, {"i": "EC:5.1.99.2", "l": "\"16-hydroxysteroid epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45503", "l": "phycocyanobilin-L-cysteinyl(84)-[allophycocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507871", "l": "Aquaporins passively transport glycerol out of cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67195", "l": "ATP + H2O + N-11-cis-retinylidenephosphatidylethanolamine(out) <=> ADP + H(+) + N-11-cis-retinylidenephosphatidylethanolamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48066", "l": "ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GD1b (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71699", "l": "H(+)(out) + L-phenylalanyl-L-leucine(out) = H(+)(in) + L-phenylalanyl-L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49877", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22667", "l": "2 1-O-(trans-sinapoyl)-beta-D-glucose <=> 1,2-di-O-sinapoyl beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196857", "l": "PANK2 phosphorylates PanK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55289", "l": "tetradecan-1-ol + tetradecanoyl-CoA => CoA + tetradecanyl tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68084", "l": "GTP + L-histidyl-[RNA ligase] = diphosphate + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2176445", "l": "SMURF2 binds SMAD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047129", "l": "opine dehydrogenase activity", "d": ["Catalysis of the reaction: (2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD+ = L-2-aminopentanoate + H+ + NADH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37095", "l": "(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64190", "l": "a fatty acid + L-tyrosine => an N-(fatty acyl)-L-tyrosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67826", "l": "a lipid X + 2 H(+) + UMP => a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50645", "l": "2-(3-methylsulfanyl)propylmalate => 3-(3-methylsulfanyl)propylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200646", "l": "Cytosolic folate export across the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14223", "l": "H(+) + methanol + sulfate => H2O + monomethyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71075", "l": "L-arginine(in) + L-cystine(out) = L-arginine(out) + L-cystine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3095889", "l": "MMACHC dealkylates RCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64980", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704408", "l": "Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15351", "l": "L-ornithine + N-acetyl-L-glutamate => L-glutamate + N(2)-acetyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12690", "l": "2 mycothiol + NAD(+) => H(+) + mycothione + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60695", "l": "(E)-non-2-enal + H2O + NADP(+) <=> (E)-non-2-enoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58389", "l": "4-aminobenzoate + all-trans-hexaprenyl diphosphate => 4-amino-3-all-trans-hexaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951499", "l": "Loading of antigenic peptides on to class I MHC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67004", "l": "a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.74", "l": "\"mRNA 5'-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66315", "l": "an alpha-mannosylinositol-1-phosphoceramide + H2O <=> a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0031834", "l": "neurokinin receptor binding", "d": ["Binding to a neurokinin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445084", "l": "Phosphorylation of L1 by SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19648", "l": "a D-threo-aldose + NAD(+) <=> a D-threo-aldono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14176", "l": "dimethylallyl diphosphate + L-tryptophan <=> 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106223", "l": "germacrene A hydroxylase activity", "d": ["Catalysis of the reaction:(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114558", "l": "Thrombin-activated PARs activate Gq (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29075", "l": "formate(out) + 2 H(+)(in) + ubiquinone-8 = CO2(out) + H(+)(out) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21067", "l": "[protein]-disulfide + 2 glutathione <=> [protein]-dithiol + glutathione disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177920", "l": "Binding of GRB2 to GAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042164", "l": "interleukin-12 alpha subunit binding", "d": ["Binding to the alpha subunit of interleukin-12."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27410", "l": "3 a menaquinone + protoporphyrinogen IX => 3 a menaquinol + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2530429", "l": "Formation of soluble VTN:C5b-C9  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45390", "l": "(9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine => H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035484", "l": "adenine/adenine mispair binding", "d": ["Binding to a double-stranded DNA region containing an A/A mispair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871266", "l": "YAP1 binds TEAD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177937", "l": "Phosphorylation of EGFR by SRC kinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35106", "l": "fusidate(in) <=> fusidate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11592", "l": "dihydromonacolin L-[lovastatin nonaketide synthase] + H2O = dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]", "d": []}, {"i": "EC:3.1.2.31", "l": "\"dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48677", "l": "6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0044769", "l": "ATPase activity, coupled to transmembrane movement of ions, rotational mechanism", "d": ["Enables the transfer of ions from one side of a membrane to the other according to the reaction: ATP + H2O + ion(in) = ADP + phosphate + ion(out), by a rotational mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428750", "l": "Gq activation by TP receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192916", "l": "Initiation of vRNA Synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033715", "l": "nucleoside oxidase activity", "d": ["Catalysis of the reactions: inosine + O2 = 9-riburonosylhypoxanthine + 2 H2O; (1a) 2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O, and (1b) 2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140858", "l": "histone H2AK15 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-15 residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52320", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryptamine = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465924", "l": "OPN1LW binds 11cRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2032775", "l": "YAP1 binds TEAD1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21218", "l": "ADP + alpha-D-ribose 1,5-bisphosphate + H(+) => ATP + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19314", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59319", "l": "D-cellobiose + O2 <=> D-cellobiono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44550", "l": "an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69860", "l": "a uridine in 12S rRNA + S-adenosyl-L-methionine => a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33745", "l": "an N-acylsphing-4-enine + phosphate => an N-acylsphing-4-enine 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.17", "l": "\"adenosine-phosphate deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46204", "l": "androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] = androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33006", "l": "(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27624", "l": "7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate => geranylgeranyl diphosphate + 7 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49445", "l": "(2-aminobenzoyl)acetyl-CoA + H2O => (2-aminobenzoyl)acetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156910", "l": "Formation of eEF1B complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942224", "l": "Filaggrin binds Keratin tonofilament:Desmosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265301", "l": "Corticotropin cleavage from POMC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183067", "l": "Localization of CBL:GRB2 to the membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9724685", "l": "IgE binds omalizumab (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10645", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H2O => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15749", "l": "(S)-mandelate + A = AH2 + phenylglyoxylate", "d": []}, {"i": "EC:1.1.99.31", "l": "\"(S)-mandelate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52828", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 = (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004838", "l": "L-tyrosine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176956", "l": "Formation of GINS complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450533", "l": "PKCdelta phosphorylates HuR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166220", "l": "FA anion diffuses laterally to UCP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27341", "l": "AH2 + NH4(+) + O2 = A + H(+) + H2O + hydroxylamine", "d": []}, {"i": "EC:1.14.99.39", "l": "\"ammonia monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10755", "l": "[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate <=> [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43423", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14920", "l": "3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140643", "l": "hydroxymethylglutaryl-CoA reductase (NADH) activity", "d": ["Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD+ <=> 3-hydroxy-3-methylglutaryl-CoA + 2 NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64317", "l": "2 dihydrogeodin + 2 H(+) + O2 => 2 (+)-geodin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33999", "l": "zymosterol = 5alpha-cholesta-7,24-dien-3beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3204303", "l": "MRE11 binds cytosolic DNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76060", "l": "RNA Polymerase III Promoter Opening at Type 1 Promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754129", "l": "CDK6 inhibitors bind CDK6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.28", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74563", "l": "aldosterone hemiacetal + UDP-alpha-D-glucuronate = aldosterone hemiacetal 18-beta-glucuronide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35519", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65849", "l": "A + a 3-oxo-Delta(1)-steroid + H2O => a steroid 1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112392", "l": "Resumption of elongation after recovery from pausing (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.43", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164617", "l": "Elongation of Extended Telomeric Chromosome End (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430311", "l": "Rsu-1 interacts with Pinch1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618407", "l": "NR1H2,3 binds the ARL4C gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51941", "l": "(1E,2S)-2-methylbutanal oxime => (1Z,2S)-2-methylbutanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694527", "l": "Loss of SAR1B GTPase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24378", "l": "AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] => apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32642", "l": "(6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420975", "l": "Ca impermeable AMPA receptor ligand binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56835", "l": "2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) <=> 2,3,6-trichlorohydroquinone + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10240", "l": "a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.9", "l": "\"enoyl-[acyl-carrier-protein] reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852331", "l": "GTSE1 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53388", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate = 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71493", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out) => an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70197", "l": "ADP + H(+) + nicotinate-adenine dinucleotide 3'-phosphate => ATP + deamido-NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41050", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55026", "l": "(3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47213", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222662", "l": "Nitric oxide enters the bacterium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19545", "l": "H2O + sn-glycerol 3-phosphocholine = glycerol + H(+) + phosphocholine", "d": []}, {"i": "EC:3.1.4.38", "l": "\"glycerophosphocholine cholinephosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.38", "l": "\"acyl-lipid Delta(6)-acetylenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676589", "l": "RANKL,sRANKL trimer binds RANK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-901047", "l": "Binding of ERp57 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640195", "l": "RRAGA,B hydrolyzes GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32631", "l": "erythromycin D + H(+) + NADPH + O2 = erythromycin C + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.154", "l": "\"erythromycin 12 hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52629", "l": "an N-fatty-acyl-L-alpha-amino acid + H2O => a fatty acid + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222723", "l": "Nitric oxide is oxidized to nitrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51558", "l": "(S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine => (S)-glaucine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22043", "l": "H2O + N-formyl-L-aspartate <=> formate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951727", "l": "cAMP binds PKA tetramer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801776", "l": "REG3A binds bacterial phospholipids (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211193", "l": "Homodimerization  of DFF40 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102117", "l": "gibberellin A9 carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: gibberellin A9 + S-adenosyl-L-methionine <=> gibberellin A9 methyl ester + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50237", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] => 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72631", "l": "Formation of the cap-binding eIF4F complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49029", "l": "(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] => (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36119", "l": "gibberellin A9 + S-adenosyl-L-methionine = O-methyl gibberellin A9 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5660665", "l": "Caspase-8 binds MALT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043237", "l": "laminin-1 binding", "d": ["Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102742", "l": "R(+)-3,4-dihydroxyphenyllactate:NADP+ oxidoreductase activity", "d": ["Catalysis of the reaction: H+ + 3,4-dihydroxyphenylpyruvate + NADPH <=> (2R)-3-(3,4-dihydroxyphenyl)lactate + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25429", "l": "ATP + N-acetyl-D-hexosamine => ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74469", "l": "a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + sulfate => a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70183", "l": "2 alpha-isomaltosyl-(1->4)-D-maltotriose = alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31441", "l": "alpha-longipinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17887", "l": "acetylene + H2O => acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47146", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52672", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate = [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate", "d": []}, {"i": "EC:2.6.1.124", "l": "\"[amino-group carrier protein]-gamma-(L-ornithyl)-L-glutamate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53785", "l": "beta-muricholate + deoxycholoyl-CoA => beta-muricholoyl-CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2404142", "l": "atROL binds RBP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41051", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35727", "l": "dodecanoyl-CoA + sn-glycerol 3-phosphate = 1-dodecanoyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49522", "l": "an adenosine in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9724685", "l": "IgE binds omalizumab (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35738", "l": "a (2R)-2-hydroxycarboxylate + NADP(+) <=> a 2-oxocarboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769044", "l": "NPAS4 binds IQSEC3 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56530", "l": "6-chloro-D-tryptophan + FAD + 2 H2O => chloride + D-tryptophan + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399930", "l": "Activation of PAK by Rac1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168923", "l": "Collagen type XVIII endostatin release (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44011", "l": "a 2-methyl-branched fatty aldehyde + H2O + NAD(+) <=> a 2-methyl fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14276", "l": "A + H2O + spermidine <=> 4-aminobutanal + AH2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38986", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019186", "l": "acyl-CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group from acyl-CoA to a nitrogen atom on an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430158", "l": "p-SLP-76 binds VAV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661217", "l": "MT1A binds zinc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27928", "l": "UMP(out) => UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791107", "l": "Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65019", "l": "chlorothalonil + H2O <=> 4-hydroxychlorothalonil + chloride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59058", "l": "dimethyl disulfide + H(+) + NADH => 2 methanethiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045481", "l": "6-endo-hydroxycineole dehydrogenase activity", "d": ["Catalysis of the reaction: 6-endo-hydroxycineole + NAD+ = 6-oxocineole + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917696", "l": "Cargo Sequestration (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-606326", "l": "HJURP:CENPA complex localizes to the centromere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16751", "l": "acetate + H(+) + phosphate => H2O + phosphonoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909738", "l": "SHP1 and SHP2 bind the common beta chain (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981931", "l": "RAC1 and CDC42 activate PAK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69128", "l": "glyoxylate + L-leucine = 4-methyl-2-oxopentanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11494", "l": "(R)-1-aminopropan-2-yl phosphate + CO2 => H(+) + O-phospho-L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32465", "l": "2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine => glycine + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70518", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29917", "l": "alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34344", "l": "(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928641", "l": "PAK binds RAC and bPIX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60949", "l": "(S)-eriodictyol + S-adenosyl-L-methionine => (S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169192", "l": "PTP1B dephosphorylates GHR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36327", "l": "ADP + dimethylallyl diphosphate = diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374701", "l": "Phosphorylation of DCC by Fyn (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0008198", "l": "ferrous iron binding", "d": ["Binding to a ferrous iron ion, Fe(II)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0042083", "l": "5,10-methylenetetrahydrofolate-dependent methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33672", "l": "an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756670", "l": "EOMES and TBXT bind the POU5F1 (OCT4) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64538", "l": "a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22717", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44822", "l": "2-demethylmenaquinol-13 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389350", "l": "Activation of Cdc42 by pVav1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63390", "l": "2 AH2 + Fe(II)-heme a => 2 A + Fe(II)-heme o + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13896", "l": "H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate <=> ADP + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38507", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21305", "l": "ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0051003", "l": "ligase activity, forming nitrogen-metal bonds, forming coordination complexes", "d": ["Catalysis of the ligation of two substances via a nitrogen-metal bond, forming a coordination complex."]}, {"i": "EC:6.6.1.-", "l": "\"Forming coordination complexes\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0061507", "l": "2',3'-cyclic GMP-AMP binding", "d": ["Binding to 2',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 2',5' and 3',5' linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809764", "l": "SBF1 binds MTMR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53808", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66955", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose <=> alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45568", "l": "[heparosan](n) = [acharan](n)", "d": []}, {"i": "EC:5.1.3.36", "l": "\"heparosan-glucuronate 5-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59569", "l": "4-aminobutanoate + ATP + L-histidine => ADP + H(+) + L-homocarnosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368279", "l": "MTIF3 binds 28S ribosomal subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444476", "l": "FPRL2 receptor binds a wide range of ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51357", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamine => (9Z)-octadecenoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016690", "l": "diarylpropane peroxidase activity", "d": ["Catalysis of the reaction: (3,4-dimethoxyphenyl)methanol + H2O2 = 3,4-dimethoxybenzaldehyde + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9733973", "l": "Bile salts bind FABP6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54415", "l": "a 3-oxo-5beta-steroid + NADP(+) <=> a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43690", "l": "L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate => N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.2.-", "l": "\"In P-halide compounds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443418", "l": "GP1b signaling involves c-Src (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047912", "l": "galacturonokinase activity", "d": ["Catalysis of the reaction: alpha-D-galacturonate + ATP = 1-phospho-alpha-D-galacturonate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30063", "l": "2-demethylmenaquinol-8 + S-adenosyl-L-methionine = H(+) + menaquinol-8 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-901047", "l": "Binding of ERp57 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47369", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0034324", "l": "O-hexanoyltransferase activity", "d": ["Catalysis of the transfer of a hexyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30782", "l": "D-gluconate + FAD + H(+) <=> 2-dehydro-D-gluconate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55945", "l": "2-chloroethanol + 2 Fe(III)-[cytochrome c] => chloroacetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26562", "l": "2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O", "d": []}, {"i": "EC:4.1.3.36", "l": "\"1,4-dihydroxy-2-naphthoyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45078", "l": "(9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12346", "l": "H(+) + L-glutamyl-tRNA(Glu) + NADPH => (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051073", "l": "adenosylcobinamide-GDP ribazoletransferase activity", "d": ["Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75233", "l": "H(+) + L-galactonate => H2O + L-galactono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43456", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74913", "l": "a (2E)-enoyl-[ACP] + AMP + diphosphate => a (2E)-enoyl fatty acid + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.56", "l": "\"lytic cellulose monooxygenase (C4-dehydrogenating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47502", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => cholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417820", "l": "P2Y9 receptor can bind to LPA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102820", "l": "norbixin methyltransferase activity", "d": ["Catalysis of the reaction: norbixin + S-adenosyl-L-methionine <=> bixin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0052827", "l": "inositol pentakisphosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol pentakisphosphate + H2O = myo-inositol tetrakisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41324", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706354", "l": "Ubiquitination of FLT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59960", "l": "N(alpha)-acetyl-D-methionine = N(alpha)-acetyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709098", "l": "DHFR dimer reduces FOLA to DHF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36353", "l": "3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine => AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27727", "l": "5-dehydro-4-deoxy-D-glucarate => 2-hydroxy-3-oxopropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72652", "l": "1,6-dihydroxyphenazine N(5)-oxide + NADPH + O2 => 1,6-dihydroxyphenazine N(5),N(10)-dioxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1370500", "l": "PRLR binds SCF beta-TrCP complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3296233", "l": "T2Rs bind bitter-tasting compounds (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20849", "l": "H(+) + O2 + phosphate + pyruvate => acetyl phosphate + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64523", "l": "acetyl-CoA + AH2 + 3 H(+) + 3 malonyl-CoA <=> A + 3 CO2 + 4 CoA + H2O + orsellinaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13473", "l": "H2O + L-tryptophan + NAD(+) = H(+) + indole-3-pyruvate + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68779", "l": "(2Z,6Z)-farnesyl diphosphate <=> diphosphate + germacrene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209322", "l": "In the absence of ARM, GRO binds to PAN and inhibits transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50946", "l": "(E)-cinnamate + H(+) + NADH => 3-phenylpropanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46773", "l": "1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204824", "l": "Interaction of Tie2 and Ang4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13038", "l": "ATP + H(+) + H2O => ITP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31043", "l": "(S)-methylmalonate semialdehyde + H2O + NAD(+) = 2 H(+) + methylmalonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2430535", "l": "MASTL phosphorylates ENSA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48111", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28390", "l": "N(6)-(D-psicosyl)-L-lysine = N(6)-(D-fructosyl)-L-lysine", "d": []}, {"i": "EC:5.1.3.41", "l": "\"fructoselysine 3-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43080", "l": "O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20954", "l": "beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13179", "l": "3-oxopropanoate + dihydroxyacetone phosphate => 6-phospho-5-dehydro-2-deoxy-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869568", "l": "NPM1 binds TFAP2A homodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578712", "l": "Importin-8 binds AGO2:miRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13437", "l": "(E)-cinnamate + UDP-alpha-D-glucose = 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP", "d": []}, {"i": "EC:2.4.1.177", "l": "\"cinnamate beta-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090555", "l": "phosphatidylethanolamine flippase activity", "d": ["Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}, {"i": "RHEA:66132", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002057", "l": "guanine binding", "d": ["Binding to guanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023983", "l": "18(R)-RvE1, E2 and E3 translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39723", "l": "a 1,2-diacyl-sn-glycerol(in) = a 1,2-diacyl-sn-glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39208", "l": "3-oxohexacosanoyl-CoA + H(+) + NADPH => (3R)-hydroxyhexacosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36860", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22101", "l": "3,5-dibromo-4-hydroxybenzonitrile + 2 H2O => 3,5-dibromo-4-hydroxybenzoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44946", "l": "1-O-alkyl-sn-glycerol + a fatty acid + H(+) => 1-O-alkyl-3-acyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938356", "l": "RMB14 binds RUNX2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015089", "l": "high-affinity copper ion transmembrane transporter activity", "d": ["Enables the transfer of a copper ions (Cu2+) from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47907", "l": "ATP + N-(acetyl)-sphing-4-enine <=> ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67872", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose = 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58551", "l": "2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093342", "l": "SDC2 multimerises (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391377", "l": "Luteinizing hormone receptor can bind LH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710354", "l": "GSDME (1-270) binds cardiolipin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22128", "l": "(1S,2R,4S)-borneol + NAD(+) = (1S,4S)-camphor + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.227", "l": "\"(-)-borneol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661625", "l": "FVIII is secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69414", "l": "glutathione disulfide + H2O + tert-butanol => 2 glutathione + tert-butyl hydroperoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38386", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158860", "l": "SULT1A1 dimer sulfonates NHABP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68603", "l": "ORC5 binds ORC2:ORC3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33998", "l": "gamma-L-glutamyl-butirosin B <=> 5-oxo-L-proline + butirosin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667965", "l": "ANKLE2 binds PP2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61814", "l": "dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678327", "l": "MIOX oxidises Ins to GlcA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36714", "l": "ATP + H(+) + H2O + O-ureido-D-serine <=> ADP + CO2 + D-cycloserine + NH4(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47977", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43607", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174171", "l": "Association of Cyclin A with the APC/C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48862", "l": "(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate => 18-HEPE + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061690", "l": "lipoamidase activity", "d": ["Catalysis of the cleavage of the amide bond to release lipoic acid from a lipoylated protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17855", "l": "5-dehydro-D-fructose + H2O2 => keto-L-sorbose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66023", "l": "H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen] <=> [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30271", "l": "2 (3,4-dimethoxyphenyl)methanol + H2O2 = 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55798", "l": "H2O + hydroquinone + NAD(+) => H(+) + NADH + O2 + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1370505", "l": "PRLR is phosphorylated at Ser-349 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327886", "l": "SLRPs bind TGF Beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69223", "l": "a (Z)-glucosinolate + H2O <=> a (Z)-N-(sulfonatooxy)alkanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15015", "l": "secologanin + tryptamine => 3alpha(S)-strictosidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27429", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28254", "l": "(3Z)-hex-3-en-1-ol + acetyl-CoA = (3Z)-hex-3-en-1-yl acetate + CoA", "d": []}, {"i": "EC:2.3.1.195", "l": "\"(Z)-3-hexen-1-ol acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74489", "l": "(-)-4'-methoxycyclopeptine + 2 AMP + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine => anthranilate + 2 ATP + O-methyl-L-tyrosine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58340", "l": "beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46119", "l": "2-dehydro-3-deoxy-D-galactonate <=> D-glyceraldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38880", "l": "a fatty acid(in) => a fatty acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823992", "l": "Expression of GSC in definitive endoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395992", "l": "p-T,4S-IRF3 is dimerized (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353435", "l": "Elongation by Pol eta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008867", "l": "galactarate dehydratase activity", "d": ["Catalysis of the reaction: galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377640", "l": "Autophosphorylation of SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43291", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61477", "l": "a sphingoid base + octadecanoyl-CoA => an N-octadecanoyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672973", "l": "MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34877", "l": "3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH => 2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20748", "l": "2-oxoglutarate + O2 + penicillin N = CO2 + deacetoxycephalosporin C + H2O + succinate", "d": []}, {"i": "EC:1.14.20.1", "l": "\"deacetoxycephalosporin-C synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634861", "l": "NPAS4 binds ARNT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54895", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide <=> [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74466", "l": "(-)-4'-methoxycyclopenine <=> 4'-methoxyviridicatin + H(+) + methyl isocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264615", "l": "Loading of acetylcholine in synaptic vesicles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22928", "l": "4-acetamidobutanoyl-CoA + H2O = 4-aminobutanoyl-CoA + acetate", "d": []}, {"i": "EC:3.5.1.51", "l": "\"4-acetamidobutyryl-CoA deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32578", "l": "(2E)-geranyl diphosphate <=> (1R,5R)-alpha-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.2.-", "l": "\"Peptidyl-amino-acid hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64286", "l": "2-phenylacetaldehyde + L-alanine => 2-phenylethylamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26037", "l": "3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15963", "l": "H(+) + taxiphyllin + UDP => 4-hydroxymandelonitrile + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851352", "l": "CCR8 binds CCL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3229181", "l": "CALM1:Ca2+ binds CNG channel (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13308", "l": "(E)-sinapate + UDP-alpha-D-glucose <=> 1-O-(trans-sinapoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3791319", "l": "NID1 degradation by MMP19 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637796", "l": "Phosphorylation of SHC1 by p-5Y-EGFRvIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6804100", "l": "HMGB1 binds LPS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362485", "l": "GHBP binds GH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23540", "l": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)", "d": []}, {"i": "EC:6.1.1.17", "l": "\"glutamate--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51577", "l": "phloretin + UDP-alpha-D-glucose => H(+) + phlorizin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57891", "l": "a quinone + 5 H(+)(in) + NADH <=> a quinol + 4 H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36315", "l": "2 H(+) + hexadecanoyl-CoA + 2 NADPH = CoA + hexadecan-1-ol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850786", "l": "SPINK6 binds KLK12 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10348", "l": "5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate", "d": []}, {"i": "EC:3.5.2.9", "l": "\"5-oxoprolinase (ATP-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938356", "l": "RMB14 binds RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39280", "l": "ATP + dodecanoate(out) + H2O => ADP + dodecanoate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55520", "l": "dimethylallyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + nerylneryl diphosphate", "d": []}, {"i": "EC:2.5.1.142", "l": "\"nerylneryl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23160", "l": "L-rhamnopyranose = L-rhamnulose", "d": []}, {"i": "EC:5.3.1.14", "l": "\"L-rhamnose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.255", "l": "\"N-terminal amino-acid N(alpha)-acetyltransferase NatA\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18446", "l": "H2O + IMP => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17853", "l": "keto-L-sorbose + O2 = 5-dehydro-D-fructose + H2O2", "d": []}, {"i": "EC:1.1.3.11", "l": "\"L-sorbose oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682020", "l": "MRN complex binds shortened telomeres (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75081", "l": "Formation of AT-AC B Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19759", "l": "NH4(+) + oxaloacetate => (3R)-3-hydroxy-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029272", "l": "Release of PLCG from FCGR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48686", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + L-lysine => [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662620", "l": "MT3 binds cadmium (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-606287", "l": "RSF complex binds the centromere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69982", "l": "(22R,23R)-22,23-dihydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38846", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74959", "l": "(3R)-3-isocyanylbutanoate + ATP + holo-[ACP] = (3R)-3-isocyanylbutanoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11482", "l": "3,4-dihydroxybenzoate + H2O + NADP(+) => 3-hydroxybenzoate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35963", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A = fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.71", "l": "\"fumitremorgin C synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41788", "l": "acetyl-CoA + holo-[ACP] = acetyl-[ACP] + CoA", "d": []}, {"i": "EC:2.3.1.38", "l": "\"[acyl-carrier-protein] S-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018766", "l": "RHOU binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29116", "l": "H(+) + menaquinone-8 + NADPH => menaquinol-8 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21138", "l": "CoA + O-acetyl-(R)-carnitine => (R)-carnitine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69071", "l": "AH2 + 2 N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline <=> A + 2 N(delta)-hydroxy-N(omega)-methyl-L-citrulline + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848864", "l": "PTK6 binds ARAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371590", "l": "HSP70 binds to HSP40:nascent protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.24", "l": "\"neopinone isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050325", "l": "tauropine dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + tauropine = H+ + NADH + pyruvate + taurine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44395", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10490", "l": "5,10-methenyltetrahydrofolate + ADP + phosphate => (6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0140674", "l": "ATP-dependent histone chaperone activity", "d": ["Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2247513", "l": "STAB1:ligand is endocytosed (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654511", "l": "FGFRL1 dimer binds FGFs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174070", "l": "Association of Cdh1 with the APC/C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28868", "l": "H(+)(in) + lactose(in) => H(+)(out) + lactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879782", "l": "Expression of AVP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44398", "l": "1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030353", "l": "fibroblast growth factor receptor antagonist activity", "d": ["Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035647", "l": "3-oxo-delta(4,5)-steroid 5-beta-reductase activity", "d": ["Catalysis of the reaction: a 3-oxo-delta-4,5-steroid + NADPH + H+ = a 5-beta-3-oxo-steroid + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59616", "l": "beta-alanyl-L-arginine + H2O = beta-alanine + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14150", "l": "luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate => H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61189", "l": "quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose => H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29159", "l": "3 a menaquinol(in) + 2 H(+)(out) + nitrite(out) = 3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66535", "l": "ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] <=> diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000112", "l": "CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64028", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine = H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0022842", "l": "narrow pore channel activity", "d": ["Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004454", "l": "ketohexokinase activity", "d": ["Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047852", "l": "diferric-transferrin reductase activity", "d": ["Catalysis of the reaction: transferrin[Fe2+]2 + NAD+ = transferrin[Fe3+]2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9716913", "l": "ESR1 binds ESR1 antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944457", "l": "MAF1 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2328037", "l": "Fibrillin-1 binds integrins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18553", "l": "(2R,3S)-tartrate + NAD(+) = dihydroxyfumarate + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.7", "l": "\"meso-tartrate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49746", "l": "CO2 + deoxyviolacein + H2O => deoxyviolaceinate + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029456", "l": "RAC1 and CDC42 activate PAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.-.-", "l": "\"Acting on carbon-nitrogen bonds, other than peptide bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58130", "l": "AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617815", "l": "BBSome binds RAB3IP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2482180", "l": "Collagen type VIII degradation by ELANE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68979", "l": "glycoursodeoxycholate + NADP(+) <=> 7-oxoglycolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64055", "l": "(13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine <=> CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199910", "l": "MSK1 activates ATF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21304", "l": "ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217013", "l": "Phosphorylation of RAD51 by tyrosine kinase Abelson family protein members (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55025", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37333", "l": "L-alanine + L-methionine => H2O + L-methionyl-L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624798", "l": "LBR binds KPNB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19134", "l": "2-oxoglutarate + 3,3',5-triiodo-L-thyronine => 3,5,3'-triiodothyropyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0015467", "l": "G-protein activated inward rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force."]}, {"i": "REACT:R-HSA-1013020", "l": "Activation of GIRK/Kir3 Channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40280", "l": "(R)-carnitine + dodecanoyl-CoA => CoA + O-dodecanoyl-R-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53005", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994148", "l": "LRRC16A binds F-actin capping protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69681", "l": "apigenin + beta-D-glucose => apigenin 7-O-beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21628", "l": "17alpha-hydroxyprogesterone + NADPH + O2 = acetate + androst-4-ene-3,17-dione + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198813", "l": "GSTO dimers reduce DeHA to AscH- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39019", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}, {"i": "EC:3.1.3.95", "l": "\"phosphatidylinositol-3,5-bisphosphate 3-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32617", "l": "(6E)-8-oxogeranial + H(+) + NADPH => (6E)-8-oxogeraniol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69685", "l": "CHEK2 phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27866", "l": "(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O = (R)-glycerate + alpha-D-mannose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63777", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30745", "l": "D-ribose + H(+) + nicotinamide => beta-nicotinamide D-riboside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49592", "l": "2-hydroxyisobutanoyl-CoA = (3S)-3-hydroxybutanoyl-CoA", "d": []}, {"i": "EC:5.4.99.64", "l": "\"2-hydroxyisobutanoyl-CoA mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40980", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871373", "l": "BMX phosphorylates RUFY1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229118", "l": "Defective SLC37A4 does not exchange G6P and Pi across the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682377", "l": "LC3 de-lipidation by ATG4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30082", "l": "ATP + CoA + crotonobetaine <=> AMP + crotonobetainyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047934", "l": "glucose 1-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: D-glucose + NAD+ = D-glucono-1,5-lactone + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30132", "l": "H2O + octanoyl-[ACP] => H(+) + holo-[ACP] + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64533", "l": "an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0015146", "l": "pentose transmembrane transporter activity", "d": ["Enables the transfer of a pentose sugar from one side of a membrane to the other. Pentose is a monosaccharide with 5 carbon atoms."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0051021", "l": "GDP-dissociation inhibitor binding", "d": ["Binding to a GDP-dissociation inhibitor protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21571", "l": "beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O <=> beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980048", "l": "DLL1 binds NOTCH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045522", "l": "interleukin-26 receptor binding", "d": ["Binding to an interleukin-26 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634669", "l": "IMPACT binds GCN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32006", "l": "(+)-copalyl diphosphate <=> diphosphate + isopimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74566", "l": "aldosterone hemiacetal + UDP-alpha-D-glucuronate <=> aldosterone hemiacetal 18-beta-glucuronide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-532603", "l": "Nephrin mediated activation of N-WASP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72631", "l": "Formation of the cap-binding eIF4F complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65032", "l": "3 a quinone + protoporphyrinogen IX = 3 a quinol + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70108", "l": "(S)-5-carboxymethyl-tetronate + o-quinone methide => H(+) + penilactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63623", "l": "ATP + dodecanoate + holo-[ACP] <=> AMP + diphosphate + dodecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749505", "l": "LRRC14 binds IKBKB and CHUK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45108", "l": "(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052617", "l": "ent-kaur-16-en-19-al oxidase activity", "d": ["Catalysis of the reaction: NADPH + ent-kaur-16-en-19-al + oxygen = H2O + NADP+ + ent-kaurenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55607", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769345", "l": "Activated glucocorticoid receptor represses NPAS4 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102384", "l": "19-O-beta-glucopyranosyl-steviol glucosyltransferase activity", "d": ["Catalysis of the reaction: 19-O-beta-glucopyranosyl-steviol + UDP-alpha-D-glucose <=> rubusoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61268", "l": "H2O + L-2-aminohexanoate + O2 = 2-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0031711", "l": "bradykinin receptor binding", "d": ["Binding to a bradykinin receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018641", "l": "6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity", "d": ["Catalysis of the reaction: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66064", "l": "2-oxohexanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9769235", "l": "MAGED1 binds NPAS4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20922", "l": "3,5-dichlorocatechol + H2O + NADP(+) => 2,4-dichlorophenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.179", "l": "\"D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54834", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.590029142468794", "identifiers": [{"i": "GO:0003682", "l": "chromatin binding", "d": ["Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730882", "l": "Phosphorylation of PKC-theta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17226", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] => 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48681", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) => a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73175", "l": "ADP(in) + FMN(out) = ADP(out) + FMN(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62828", "l": "GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28718", "l": "(R)-malate(in) + 2 H(+)(in) <=> (R)-malate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.2", "l": "\"membrane alanyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444523", "l": "CXCR5 binds CXCL13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52242", "l": "4 H(+) + 2 MnO2 => 2 H2O + 2 Mn(2+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114352", "l": "Sequestration of tBID by BCL-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391935", "l": "DP1 receptor can bind PGD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17574", "l": "demethylmacrocin + S-adenosyl-L-methionine => H(+) + macrocin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60696", "l": "(R)-lavandulyl diphosphate + H2O = (R)-lavandulol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0048020", "l": "CCR chemokine receptor binding", "d": ["Binding to a CCR chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76107", "l": "(11R)-methyl carlactonoate + 2-oxoglutarate + O2 = (11R)-hydroxymethyl carlactonoate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11911", "l": "H2O + nonane-4,6-dione <=> butanoate + H(+) + pentan-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61314", "l": "germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018747", "l": "RHOQ GEFs activate RHOQ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018572", "l": "EGFR phosphorylates NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032422", "l": "purine-rich negative regulatory element binding", "d": ["Binding to a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47159", "l": "7alpha,25-dihydroxycholesterol + NAD(+) <=> 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45776", "l": "(indol-3-yl)acetonitrile + 2 H2O = (indol-3-yl)acetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59349", "l": "D-maltobiono-1,5-lactone + H2O => D-maltobionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42788", "l": "cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.186", "l": "\"23S rRNA (cytidine(2498)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68649", "l": "2 L-cysteine => H(+) + hydrogen sulfide + L-lanthionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852010", "l": "BTNL2 binds activated T cells surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941312", "l": "TUT4,TUT7 oligouridylate mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22273", "l": "(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692250", "l": "WT1, NR5A1 (SF1), GATA4, ZFPM2 bind the SRY gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451311", "l": "Activation of Ca-permeable Kainate receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139842", "l": "Binding of Syk tyrosine kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390886", "l": "HRH4 binds Hist (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17441", "l": "2-oxoglutarate + L-cysteine = 2-oxo-3-sulfanylpropanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.3", "l": "\"cysteine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49020", "l": "2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69980", "l": "(22R,23R)-22,23-dihydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-482772", "l": "Release of platelet cytosolic components (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37421", "l": "1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21711", "l": "H2O + S-adenosyl-L-homocysteine <=> adenosine + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607023", "l": "factor IXa associates with cell membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58484", "l": "H2O + N-(acetyl)-sphing-4-enine = acetate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69377", "l": "2-hydroxydodecanoate + O2 => 2-oxododecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450494", "l": "HuR binds mRNAs in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23016", "l": "(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) = (2R,3R)-dihydrokaempferol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672969", "l": "Phosphorylation of RAF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24336", "l": "a carboxylate + ATP + CoA = AMP + an acyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32433", "l": "(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+) => (1R,4S)-menthone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45077", "l": "(9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] => (9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46866", "l": "a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791155", "l": "Laminin-322 degradation by MMP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685838", "l": "CX3 complex binds D-loop structures (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75506", "l": "glycocholate(out) + n H(+)(out) <=> glycocholate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15075", "l": "D-glucuronate + N(2),6-disulfo-D-glucosamine => 3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21839", "l": "D-arabinonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52639", "l": "2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 <=> a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.52", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190141", "l": "ALAD binds to Pb2+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694527", "l": "Loss of SAR1B GTPase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110215", "l": "Cleavage of uracil by UNG glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010174", "l": "nucleoside transmembrane transporter activity, against a concentration gradient", "d": ["Enables the transfer of a nucleoside, from one side of a membrane to the other, up a concentration gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102902", "l": "isopimaradienal hydroxylase activity", "d": ["Catalysis of the reaction: isopimaradienal + NADPH + O2 <=> isopimaric acid + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64461", "l": "acetyl phosphate + L-lysyl-[protein] => H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42546", "l": "pseudouridine(32) in tRNA => uridine(32) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53588", "l": "NAD(+) + resolvin D2 = 16-oxoresolvin D2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5096538", "l": "Defective LFNG does not transfer GlcNAc to Pre-NOTCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-994148", "l": "LRRC16A binds F-actin capping protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691131", "l": "CANDI binds CUL1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66236", "l": "IC-asc-C9-CoA + O2 = H2O2 + IC-asc-DeltaC9-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38673", "l": "sphinganine 1-phosphate(out) => sphinganine 1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21700", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": []}, {"i": "EC:3.1.3.77", "l": "\"acireductone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46111", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2 <=> (2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43382", "l": "L-arginyl-[protein] + phosphate => H2O + N(omega)-phospho-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12729", "l": "lutein = (3R,3'S)-zeaxanthin", "d": []}, {"i": "EC:5.3.3.22", "l": "\"lutein isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159773", "l": "Furin cleaves pro-protein S to protein S (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51811", "l": "(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209183", "l": "Scaffolding protein CKA binds BSK and phosphorylated HEP kinases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43072", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53321", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose => alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429860", "l": "DCP1-DCP2 complex decaps mRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.14", "l": "\"polyamine oxidase (propane-1,3-diamine-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63929", "l": "an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000810", "l": "diacylglycerol diphosphate phosphatase activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68435", "l": "lutein + O2 <=> (3R)-hydroxy-beta-ionone + (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33704", "l": "(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA => CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25908", "l": "an alditol + O2 = an aldose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660663", "l": "Caspase-8 cleaves IL1B precursor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14495", "l": "ADP-D-ribose + L-arginyl-[dinitrogen reductase] => H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004945", "l": "angiotensin type II receptor activity", "d": ["An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47956", "l": "3-maleylpyruvate + H2O = H(+) + maleate + pyruvate", "d": []}, {"i": "EC:3.7.1.23", "l": "\"maleylpyruvate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52267", "l": "3-(aminomethyl)indole + 2 S-adenosyl-L-methionine <=> gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785898", "l": "IL4R binds JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56145", "l": "a quinol + nitrate => a quinone + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51590", "l": "5-pyridoxolactone + H(+) + NADH => isopyridoxal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174731", "l": "Degradation of newly synthesized ApoB-48 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12480", "l": "5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine", "d": []}, {"i": "EC:2.6.1.43", "l": "\"aminolevulinate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37554", "l": "3-dehydro-D-glucose 6-phosphate + L-glutamate <=> 2-oxoglutarate + D-kanosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181352", "l": "LEFTY binds NODAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17175", "l": "glutathione + spermidine => glutathionylspermidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24369", "l": "L-ornithine => L-proline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71717", "l": "H(+)(in) + L-leucyl-L-leucine(in) => H(+)(out) + L-leucyl-L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38188", "l": "19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase] => 17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10216", "l": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase]", "d": []}, {"i": "EC:2.7.11.23", "l": "\"[RNA-polymerase]-subunit kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.2.19", "l": "\"streptothricin hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46537", "l": "(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659764", "l": "Defective SLC6A2 does not cotransport NAd, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28036", "l": "[thioredoxin]-dithiol + ADP => [thioredoxin]-disulfide + dADP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56969", "l": "dCTP + pyruvate => dCDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22287", "l": "2 H(+) + H2O + N-carbamoylputrescine <=> CO2 + NH4(+) + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26007", "l": "di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate => beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74198", "l": "aspulvinone E + O2 <=> (5Z)-3-(3,4-dihydroxyphenyl)-5-[(3,4-dihydroxyphenyl)methylidene]-5-oxo-2,5-dihydrofuran-3-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392295", "l": "Gbeta:gamma recruits PI3K gamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928624", "l": "EPHBs bind EFNBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50627", "l": "acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O <=> a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16429", "l": "ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": []}, {"i": "EC:6.3.2.9", "l": "\"UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674529", "l": "AAMP binds to TBXA2R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72691", "l": "Formation of the 43S pre-initiation complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.47", "l": "\"8-amino-7-oxononanoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212356", "l": "Formation of CSL-NICD coactivator complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709842", "l": "MAVS binds TOMM70 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12304", "l": "(S)-2-amino-6-oxohexanoate + H2O + NADP(+) = 2 H(+) + L-2-aminoadipate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709454", "l": "EPOR binds EPOR agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56347", "l": "a 7-hydroxyisoflavone + UDP-alpha-D-glucose <=> a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936729", "l": "sulfate is activated to APS (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45515", "l": "phycocyanobilin-L-cysteinyl(155)-[C-phycocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[C-phycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627104", "l": "XIAP binds CASP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73884", "l": "guanidine(out) => guanidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371582", "l": "HSBP1 binds HSF1 trimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20801", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51554", "l": "H(+) + L-xylo-3-hexulose + NADPH => D-sorbitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110360", "l": "Recruitment of POLB to the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139905", "l": "Translocation of activated BAD protein to mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63606", "l": "[Pyr1]apelin-12 + L-phenylalanine => [Pyr1]apelin-13 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43634", "l": "an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe) => an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2203480", "l": "COLEC11 binds ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22650", "l": "apo-[cytochrome c] + heme b => holo-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209193", "l": "Phosphorylated AP-1, Phospho JRA:Phospho KAY dissociates from CKA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655193", "l": "KIAA0101 double monoubiquitination (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77094", "l": "Formation of cap binding complex (CBC) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031522", "l": "NR1H2,3 binds the APOE gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30916", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O => a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875451", "l": "MET phosphorylates CBL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035237", "l": "corazonin receptor activity", "d": ["Combining with the neuropeptide corazonin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57548", "l": "(S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase] = [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034901", "l": "endosulfan hydroxyether dehydrogenase activity", "d": ["Catalysis of the reaction: endosulfan hydroxyether = endosulfan lactone + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626220", "l": "C2CD3 binds the mother centriole (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43547", "l": "ATP + L-glutamate + tyramine <=> ADP + gamma-L-glutamyltyramine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265160", "l": "Insulin secretory granule translocates to cell cortex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45785", "l": "2 H2O + phenylpropanonitrile => 3-phenylpropanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29639", "l": "D-maltohexaose + H2O = alpha-D-glucose + D-maltopentaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61784", "l": "L-allulose = keto-L-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44900", "l": "D-galactono-1,4-lactone + H2O = D-galactonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.57", "l": "\"isopullulanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24011", "l": "ATP + hypotaurocyamine <=> ADP + H(+) + N(omega)-phosphohypotaurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21681", "l": "(2S)-2-hydroxyphytanate + O2 => 2-oxophytanate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109862", "l": "MAP2K2 phosphorylates MAPK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47745", "l": "demethylphylloquinone + H(+) + NADPH => demethylphylloquinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9716913", "l": "ESR1 binds ESR1 antagonists (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42726", "l": "2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9726949", "l": "PTGIR binds PTGIR agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66759", "l": "ATP + domoate(in) + H2O <=> ADP + domoate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874718", "l": "TTPA binds alpha-TOH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28520", "l": "D-glycero-beta-D-manno-heptose 1-phosphate + phosphate => D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77608", "l": "Binding of A1CF to stem-looped RNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432426", "l": "CRY is activated by light and binds to cytosolic TIM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008876", "l": "quinoprotein glucose dehydrogenase activity", "d": ["Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9634861", "l": "NPAS4 binds ARNT2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53177", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67572", "l": "3'-phosphoadenylyl sulfate + alpha-muricholate = adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55484", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5545484", "l": "MLH1 variants-defective DNA mismatch repair (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624954", "l": "INPP5E translocates to the primary cilium (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27937", "l": "(3S)-3-hydroxy-D-aspartate <=> glycine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202137", "l": "AKT1 binds eNOS complex via HSP90 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71601", "l": "2-oxoglutarate(in) + maleate(out) => 2-oxoglutarate(out) + maleate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74532", "l": "AH2 + archaetidylglycerol + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaetidylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140082", "l": "SUMO-ubiquitin ligase activity", "d": ["Isoenergetic transfer of SUMO from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53402", "l": "(13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.25", "l": "\"phenylalanine/tyrosine ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37258", "l": "A + D-asparagine + H2O <=> 2-oxosuccinamate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016165", "l": "linoleate 13S-lipoxygenase activity", "d": ["Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51689", "l": "galactitol + NAD(+) => H(+) + keto-L-tagatose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.104", "l": "\"peptidoglycan-N-acetylglucosamine deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70971", "l": "citrate <=> isocitrate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43479", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 <=> 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47687", "l": "[(1->2)-beta-D-glucosyl](n) + phosphate <=> [(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17502", "l": "H2O + polyneuridine aldehyde => 16-epivellosimine + CO2 + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0022878", "l": "protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199298", "l": "AKT phosphorylates CREB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31869", "l": "baccharis oxide => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42088", "l": "all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75076", "l": "dihydro-6-demethylsterigmatocystin + S-adenosyl-L-methionine => dihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35301", "l": "3-oxooctadecanoyl-CoA + H(+) + NADPH => 3-hydroxyoctadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015191", "l": "L-methionine transmembrane transporter activity", "d": ["Enables the transfer of L-methionine from one side of a membrane to the other. L-methionine is 2-amino-4-(methylthio)butanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8979071", "l": "KDM6B binds iron (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69865", "l": "a 5-methyluridine in mRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64513", "l": "(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine => 6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13156", "l": "(R)-glycerate + CO2 + NAD(+) <=> 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203553", "l": "eNOS binds NOSIP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9718020", "l": "PTGFR binds PTGFR agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164617", "l": "Elongation of Extended Telomeric Chromosome End (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379464", "l": "COMT transfers Met to DOPAC to form HVA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50578", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30330", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167537", "l": "Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23394", "l": "n a ribonucleoside 5'-phosphate + n H(+) => (n-1) H2O + RNA(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592297", "l": "Full activation of MMP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111930", "l": "Adenylate cyclase produces cAMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15064", "l": "2 a Fe(II)-siderophore + H(+) + NAD(+) <=> 2 a Fe(III)-siderophore + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454928", "l": "ABCG4 may mediate cholesterol efflux (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71466", "l": "H2O + substance P <=> Gly-L-Leu-L-Met-NH2 + substance P(1-8)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27722", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose = 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP", "d": []}, {"i": "EC:2.4.2.53", "l": "\"undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10442", "l": "D-gluconate + H(+) => D-glucono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42621", "l": "(Z)-2-methylureidoacrylate + H(+) + H2O => (Z)-2-methylaminoacrylate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2429719", "l": "MCPH1 sequesters condensin II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52300", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60806", "l": "CO2 + gibberellin A17 + H(+) + succinate => 2-oxoglutarate + gibberellin A19 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31072", "l": "(S)-methylmalonate semialdehyde + L-alanine => (S)-3-amino-2-methylpropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62361", "l": "FMN-N(5)-peroxide + uracil => (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41424", "l": "2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2 = formate + grixazone A + H(+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950398", "l": "CANX dissociates from IL27:EBI3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25966", "l": "benzil + H(+) + NADPH => (R)-benzoin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74435", "l": "a 1-acyl-sn-glycero-3-phosphocholine(out) + H(+)(out) = a 1-acyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15073", "l": "3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O = D-glucuronate + N(2),6-disulfo-D-glucosamine", "d": []}, {"i": "EC:3.2.1.56", "l": "\"glucuronosyl-disulfoglucosamine glucuronidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18562", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033509", "l": "USP9X binds Ub:PEX5L (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21771", "l": "H2O + N-methyl-L-alanine + NADP(+) <=> H(+) + methylamine + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10629", "l": "phosphate + tRNA(n+1) => a ribonucleoside 5'-diphosphate + tRNA(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29832", "l": "Ni(2+)(in) => Ni(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11588", "l": "A + H2O + isoquinoline = AH2 + isoquinolin-1(2H)-one", "d": []}, {"i": "EC:1.3.99.16", "l": "\"isoquinoline 1-oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0032440", "l": "2-alkenal reductase [NAD(P)+] activity", "d": ["Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+."]}, {"i": "EC:1.3.1.74", "l": "\"2-alkenal reductase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55344", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9711016", "l": "SARS-CoV-1 nsp3 deubiquinates K63-linked pUb-STING (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451311", "l": "Activation of Ca-permeable Kainate receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46630", "l": "androst-5-en-3beta,17beta-diol + NADP(+) => 3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43098", "l": "H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0031543", "l": "peptidyl-proline dioxygenase activity", "d": ["Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865182", "l": "OTUD7A hydrolyses K11diUb (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863013", "l": "CDK5 binds p25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11530", "l": "2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate => 2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53660", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201515", "l": "Active ALK recruits PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16918", "l": "2,6-dihydroxypyridine + H(+) + NADH + O2 => 2,3,6-trihydroxypyridine + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36128", "l": "gibberellin A34 + S-adenosyl-L-methionine => O-methyl gibberellin A34 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41849", "l": "(2E)-octenoyl-[ACP] + H(+) + NADPH => NADP(+) + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592371", "l": "Initial activation of proMMP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004983", "l": "neuropeptide Y receptor activity", "d": ["Combining with neuropeptide Y to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682388", "l": "Autophagosome maturation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61646", "l": "2 Fe(III)-[cytochrome b5] + H2O + L-arginine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55130", "l": "(2E)-5-methylhexenoyl-[ACP] + H2O => (3R)-hydroxy-5-methylhexanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0019187", "l": "beta-1,4-mannosyltransferase activity", "d": ["Catalysis of the transfer of a mannose residue to an oligosaccharide, forming a beta-(1->4) linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34066", "l": "2-deoxystreptamine + UDP-alpha-D-glucose <=> 2'-deamino-2'-hydroxyparomamine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35183", "l": "5-hydroxythiophene-2-carbonyl-CoA + H2O = 4-carboxy-2-thioxobutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0003918", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity", "d": ["Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9670673", "l": "FIX is secreted (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69470", "l": "L-glutamate + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose => 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062063", "l": "BBSome binding", "d": ["Binding to a BBSome complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73801", "l": "dehydroechinulin + diphosphate => dimethylallyl diphosphate + isoechinulin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362416", "l": "Frataxin binds iron (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578965", "l": "TNRC6A binds AGO2:miRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51771", "l": "2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate <=> 4-prenylphlormethylbutanophenone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39997", "l": "a fatty acid + ethanolamine => an N-acylethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36542", "l": "hexadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800870", "l": "NDUF subunits bind to form the FP subcomplex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65062", "l": "7-oxotaurolithocholate + H(+) + NADPH => NADP(+) + taurochenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.76", "l": "\"arylalkyl acylamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174445", "l": "RPA binds to the Flap on the C-strand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40616", "l": "H2O + tridecanoylglycerol => 2,3-didecanoyl-sn-glycerol + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75914", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine <=> a fatty acid + H(+) + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354073", "l": "Autophosphorylation of PTK2 at Y397 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430183", "l": "NCK binds PAK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17420", "l": "ATP + N-acetyl-D-glucosamine <=> ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0017134", "l": "fibroblast growth factor binding", "d": ["Binding to a fibroblast growth factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928584", "l": "p-EPHs bind SRC,FYN,YES,LYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368119", "l": "Expression of CLOCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264458", "l": "Proteasome mediated degradation of COP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419440", "l": "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653974", "l": "Ragulator binds Rag dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2106614", "l": "Duplex miRNA is loaded into Argonaute (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38994", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62532", "l": "digitoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydrodigitoxin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032021", "l": "RvT1-4 translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68149", "l": "2-octanone + H(+) + NADPH => (2R)-octan-2-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673760", "l": "Ligand-independent dimerization of membrane-tethered fusions of PDGFRA or PDGFRB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015614", "l": "ABC-type D-xylose transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-xylose(out) -> ADP + phosphate + D-xylose(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090523", "l": "cytochrome-b5 reductase activity, acting on NADPH", "d": ["Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome b(5) = NADP+ + 2 ferrocytochrome b(5)."]}, {"i": "RHEA:64576", "l": "2 Fe(III)-[cytochrome b5] + NADPH = 2 Fe(II)-[cytochrome b5] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31827", "l": "(2E,6E)-farnesyl diphosphate = (+)-gamma-cadinene + diphosphate", "d": []}, {"i": "EC:4.2.3.92", "l": "\"(+)-gamma-cadinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453356", "l": "PYGB dimer, b form + 2 AMP <=> PYGB b dimer:AMP complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25646", "l": "(2R,5R)-isomenthone + NADP(+) => (R)-pulegone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68048", "l": "[protein]-D-aspartate + S-adenosyl-L-methionine = [protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70142", "l": "6-deoxo-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-28-nortyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51207", "l": "6-trans-leukotriene B4 + NADP(+) <=> 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110311", "l": "POLZ extends translesion synthesis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24163", "l": "D-galactose + O2 <=> D-galacto-hexodialdose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64654", "l": "(E)-4-coumaroyl-CoA + H(+) + NADPH => (E)-4-coumaraldehyde + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24010", "l": "ADP + H(+) + N(omega)-phosphohypotaurocyamine => ATP + hypotaurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848077", "l": "PTK6 phosphorylates STAP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44357", "l": "nogalaviketone => methyl nogalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55960", "l": "4-(trimethylamino)butanoate + ATP + CoA = 4-(trimethylamino)butanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001092", "l": "TFIIA-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase II transcription factor belonging to the TFIIA complex, one of the complexes involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018464", "l": "3-hydroxypimeloyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxypimelyl-CoA + NAD+ = 3-oxopimelyl-CoA + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373733", "l": "Neurofascin binds contactin-1:CASPR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102789", "l": "UDP-D-glucose:cyanidin 5-O-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin = H+ + cyanidin 5-O-beta-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218814", "l": "PAK2 autophorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39537", "l": "(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18157", "l": "ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25655", "l": "aminoacetone + CO2 => (2S)-2-amino-3-oxobutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60923", "l": "2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2 <=> a cytidine in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827867", "l": "Expression of TFAP2C in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052925", "l": "dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity", "d": ["Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653514", "l": "USP17L2 deubiquitinates RCE1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001586", "l": "Gi/o-coupled serotonin receptor activity", "d": ["Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9706399", "l": "RHOBTB3 hydrolyzes ATP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27858", "l": "2',3'-cyclophospho-GMP + H2O = 3'-GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52563", "l": "2-dehydro-D-erythronate <=> 3-dehydro-D-erythronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44230", "l": "9-decenoyl-CoA + AMP + diphosphate => 9-decenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12285", "l": "3-hydroxy-3-methylglutarate + succinyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66499", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34384", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose => beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28557", "l": "D-mannose 6-phosphate + H2O <=> D-mannose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58349", "l": "2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 => 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462003", "l": "HNP1-4 are stored in primary neutrophil granules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71034", "l": "L-cysteine(in) + L-phenylalanine(out) <=> L-cysteine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49894", "l": "(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65195", "l": "2 2-oxoglutarate + 2 O2 + preaustinoid A <=> berkeleytrione + 2 CO2 + H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31004", "l": "(S)-2,3-epoxysqualene => germanicol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902301", "l": "galactarate transmembrane transporter activity", "d": ["Enables the transfer of galactaric acid anion (galactarate) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050079", "l": "acetylenecarboxylate hydratase activity, producing 3-oxopropanoate", "d": ["Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45097", "l": "(9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48634", "l": "5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48700", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol = a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14545", "l": "H2O + nicotinamide = NH4(+) + nicotinate", "d": []}, {"i": "EC:3.5.1.19", "l": "\"nicotinamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18707", "l": "a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.7.-.-", "l": "\"Carbon-phosphorus lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51209", "l": "20-hydroxy-leukotriene B4 + NADP(+) => 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52736", "l": "(Z)-indolylmethyl desulfoglucosinolate + 3'-phosphoadenylyl sulfate = (Z)-glucobrassicin + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50110", "l": "CoA + H(+) + N-hexadecanoyl-taurine => hexadecanoyl-CoA + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39375", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA = (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26222", "l": "abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70203", "l": "N-methyldopaminechrome = 5,6-dihydroxyindole-N-methyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40342", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60164", "l": "a guanosine in RNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700175", "l": "Active ALK phosphorylates SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42134", "l": "nocardicin C => isonocardicin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33820", "l": "3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate => 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58717", "l": "FADH2-C4alpha-hydroperoxide + NADH + rifampicin => FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354097", "l": "Activation of Talin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65465", "l": "2-methylbutan-1-ol + butanoyl-CoA => 2-methylbutyl butanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22131", "l": "(1S,2R,4S)-borneol + NAD(+) <=> (1S,4S)-camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70416", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + H2O => (3,5-dihydroxyphenyl)acetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937807", "l": "SRC phosphorylates RUNX3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48992", "l": "1,3,7-trimethylurate + H(+) + NADH + O2 = 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.212", "l": "\"1,3,7-trimethyluric acid 5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164840", "l": "ADP and Pi bind to ATPase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22963", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] <=> calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.184", "l": "\"carbonyl reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047010", "l": "hydroxycyclohexanecarboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD+ = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16201", "l": "4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate", "d": []}, {"i": "EC:4.1.3.38", "l": "\"aminodeoxychorismate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12022", "l": "a monocarboxylate + NH4(+) => a monocarboxylic acid amide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5226979", "l": "ADD1:ADD2 binds DMTN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73689", "l": "dAMP(in) + phosphate(out) => dAMP(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49423", "l": "ATP + valienone <=> ADP + H(+) + valienone 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246506", "l": "botC HC:LC binds GT1b on the target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850777", "l": "SPINK6 binds KLK14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49864", "l": "(+)-dehydrodiconiferyl acid + 2 a quinone + H2O = (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30939", "l": "ATP + dIDP = ADP + dITP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2032781", "l": "WWTR1 (TAZ) binds TEAD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19341", "l": "2 H(+) + O2 + octane + 2 reduced [rubredoxin] = H2O + octan-1-ol + 2 oxidized [rubredoxin]", "d": []}, {"i": "EC:1.14.15.3", "l": "\"alkane 1-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36516", "l": "H(+) + malonyl-CoA + tetracosanoyl-CoA => 3-oxohexacosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21747", "l": "S-adenosyl-L-methionine <=> 1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33090", "l": "cyclic dehypoxanthinylfutalosinate <=> 1,4-dihydroxy-6-naphthoate + chemical entity", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-990489", "l": "Kinesin-13 is a dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38761", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428750", "l": "Gq activation by TP receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73885", "l": "guanidine(in) => guanidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39570", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17247", "l": "6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2 => 3-hydroxyanthranilate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41607", "l": "1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61360", "l": "ATP + H2O + pheophorbide a(in) = ADP + H(+) + pheophorbide a(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811427", "l": "COPI vesicle uncoating at the ER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67187", "l": "(glycyl)(n)-glycyl-L-glutamyl-[protein] + ATP + glycine <=> (glycyl)(n+1)-glycyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48868", "l": "H2O + NADH = AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5226999", "l": "ADD1:ADD3 binds DMTN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797803", "l": "PTPRD binds SLITRK1-6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63333", "l": "alpha-L-arabinopyanose => beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655833", "l": "Expression of TM7SF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2564824", "l": "NADPH reduces NDOR1:CIAPIN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17899", "l": "(S)-1-phenylethanol + AH2 => A + ethylbenzene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51791", "l": "2-hydroxybenzoyl-5'-AMP + CoA <=> 2-hydroxybenzoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55153", "l": "H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein] => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865182", "l": "OTUD7A hydrolyses K11diUb (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70573", "l": "argininosuccinate <=> fumarate + arginine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47585", "l": "ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GT1c (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61151", "l": "myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39374", "l": "3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74733", "l": "Insulin receptor de-phosphorylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37167", "l": "(2E,6E)-farnesol + NAD(+) = (2E,6E)-farnesal + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.354", "l": "\"farnesol dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62411", "l": "3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine <=> 1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75695", "l": "2'-deoxycytidine(in) = 2'-deoxycytidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803914", "l": "TP53 binds the RGCC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043755", "l": "alpha-ribazole phosphatase activity", "d": ["Catalysis of the reaction: alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.41", "l": "\"yapsin 1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64026", "l": "H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14974", "l": "L-aspartate => D-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33165", "l": "beta-nicotinamide D-riboside(out) => beta-nicotinamide D-riboside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35822", "l": "5,6,7,8-tetrahydromethanopterin + NADP(+) <=> 7,8-dihydromethanopterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32304", "l": "(2R)-homocitrate => (2R,3S)-homoisocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004130", "l": "cytochrome-c peroxidase activity", "d": ["Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31759", "l": "dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.234", "l": "\"dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11573", "l": "FAD + H(+) + H2O + lithocholate => chenodeoxycholate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71965", "l": "(R)-2-hydroxyglutarate(in) + 3 Na(+)(in) => (R)-2-hydroxyglutarate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34153", "l": "2-deoxystreptamine + 2-oxoglutaramate => 3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928607", "l": "p-EPHs bind VAV2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37515", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800052", "l": "SREBP1A,1C binds the SCD gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113449", "l": "RNA Polymerase III Transcriptional Pause at Terminator Sequence (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5658438", "l": "SPRED dimer binds NF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786650", "l": "DDHD1,2 hydrolyse PA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28466", "l": "pyridoxamine(in) = pyridoxamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66969", "l": "alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64183", "l": "an N-(fatty acyl)-L-tryptophan + H2O <=> a fatty acid + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75158", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> diphosphate + verrucosan-2beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629918", "l": "NEIL1 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62140", "l": "dTMP + GTP = dTDP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43009", "l": "D-serine => 2-aminoprop-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11893", "l": "6-O-methylnorlaudanosoline + S-adenosyl-L-methionine => H(+) + nororientaline + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613768", "l": "SOX10, POU3F1 and POU3F2 bind EGR2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987120", "l": "JAK1 binds IFNLR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20230", "l": "2,3-dihydroxybenzoate + ATP + H(+) => 2,3-dihydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63233", "l": "(2E)-octenoyl-CoA + H(+) + NADH => NAD(+) + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032775", "l": "YAP1 binds TEAD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17907", "l": "3-hydroxypyruvate + H(+) + NADH => (R)-glycerate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66754", "l": "(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate => (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047583", "l": "4-methyloxaloacetate esterase activity", "d": ["Catalysis of the reaction: 4-methoxy-2,4-dioxobutanoate + H2O = H+ + methanol + oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22781", "l": "(9Z,12Z)-octadecadienoate + O2 => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034858", "l": "2-hydroxybenzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: 2-hydroxybenzothiazole + 1/2 O2 = 2,6-dihydroxybenzothiazole."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38032", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) => (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55818", "l": "5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine => a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27545", "l": "methanol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9621179", "l": "Cinaciguat binds sGC:NO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17079", "l": "formaldehyde + H2O2 + sarcosine => H2O + N,N-dimethylglycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37226", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-517674", "l": "p-S158,221-HuR binds mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030266", "l": "quinate 3-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: (-)-quinate + NAD+ = (-)-3-dehydroquinate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57277", "l": "a 2'-deoxyguanosine in DNA + glyoxal => an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25012", "l": "N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28540", "l": "ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55182", "l": "2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylnonanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61760", "l": "rebaudioside B + UDP-alpha-D-glucose = rebaudioside A + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160915", "l": "Receptor-mediated uptake of HA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990846", "l": "ribonucleoside-diphosphate reductase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of ribonucleoside-diphosphate reductase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14049", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol", "d": []}, {"i": "EC:1.14.14.176", "l": "\"taxadiene 5alpha-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.19", "l": "\"tryptophan dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49135", "l": "an adenosine in tRNA + S-adenosyl-L-methionine <=> an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69685", "l": "CHEK2 phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749215", "l": "MCM8 binds CDC6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72114", "l": "L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out) <=> L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39650", "l": "AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14518", "l": "(E)-feruloyl-CoA + H2O => 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56430", "l": "(9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21815", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64976", "l": "8-oxo-dGTP + 2 H2O = 8-oxo-dGMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58047", "l": "a long-chain fatty acyl-CoA + alpha,alpha-trehalose <=> 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27596", "l": "all-trans-nonaprenyl diphosphate + 5 diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29071", "l": "a ubiquinone + formate + H(+) = a ubiquinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16806", "l": "2-oxoglutarate + deacetoxycephalosporin C + O2 => CO2 + deacetylcephalosporin C + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632677", "l": "PTCH is internalized (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73056", "l": "estrone 3-sulfate(out) + hydrogencarbonate(in) => estrone 3-sulfate(in) + hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22480", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) = 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174224", "l": "Dissociation of Cdc20 from APC/C complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.2", "l": "\"peptidyl-glycinamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45387", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12445", "l": "hexadecanal + NADP(+) => (2E)-hexadecenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24099", "l": "isoorientin + S-adenosyl-L-methionine <=> H(+) + isoscoparin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19568", "l": "(2E)-geranyl diphosphate + H2O <=> diphosphate + sabinene hydrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35763", "l": "8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30943", "l": "FAD + H(+) + octanoyl-CoA = (2E)-octenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3076905", "l": "Extracellular BTD hydrolyses BCTN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254251", "l": "ERBB4s80 binds YAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377644", "l": "Release of CSK from SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20263", "l": "CO2 + CoA + olivetol => 3,5,7-trioxododecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.137", "l": "\"N-methylcarbamate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28000", "l": "H(+) + phosphate + thiamine phosphate => H2O + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102420", "l": "sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity", "d": ["Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = coenzyme A + 1-C16:0-alpha,omega-dicarboxyl-2-lysophosphatidate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56300", "l": "[thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein] = [thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42609", "l": "a plastoquinone + (n+1) H(+)(in) + NADH => a plastoquinol + n H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168848", "l": "tBID binds to inactive BAK protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14704", "l": "2 CoA + NAD(+) <=> CoA-disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51788", "l": "2-hydroxybenzoyl-5'-AMP + CoA = 2-hydroxybenzoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70982", "l": "Fumarate + H2O <=> (S)-Malate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353481", "l": "5-methylcytosine G/T mismatch specific DNA glycosylase mediated recognition and binding of thymine opposite guanine at CpG sequences (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36942", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA <=> (9Z)-tetradecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034023", "l": "5-(carboxyamino)imidazole ribonucleotide mutase activity", "d": ["Catalysis of the reaction: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72077", "l": "ADP + H(+) + ophthalmate + phosphate => ATP + gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61173", "l": "myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22177", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19628", "l": "L-threonine <=> acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928631", "l": "GIT1 binds bPIX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17361", "l": "3-oxo-3-ureidopropanoate + H2O = H(+) + malonate + urea", "d": []}, {"i": "EC:3.5.1.95", "l": "\"N-malonylurea hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141048", "l": "membrane tag activity", "d": ["A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to a lipid, where it acts as a marker for a membrane, recognized by the cellular apparatus to target the tagged protein for some cellular process such as autophagy."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55035", "l": "an N-methylornithine lipid + S-adenosyl-L-methionine <=> an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508451", "l": "PTK2B is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58457", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O => (R)-glycerate + D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50020", "l": "decanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132085", "l": "Cleavage of C3 by surface-bound C3 convertases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800870", "l": "NDUF subunits bind to form the FP subcomplex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0030295", "l": "protein kinase activator activity", "d": ["Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2219524", "l": "PDPK1 binds PIP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19603", "l": "2,3,5-trihydroxytoluene + H2O + NAD(+) => H(+) + NADH + O2 + orcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49560", "l": "D-sedoheptulose 7-phosphate = (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate", "d": []}, {"i": "EC:4.2.3.154", "l": "\"demethyl-4-deoxygadusol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21225", "l": "CDP-choline + sphing-4-enine => CMP + H(+) + sphing-4-enine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102531", "l": "ecdysteroid-phosphate phosphatase activity", "d": ["Catalysis of the reaction: H2O + an ecdysteroid 22-phosphate = hydrogenphosphate + an ecdysteroid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004873", "l": "asialoglycoprotein receptor activity", "d": ["Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42387", "l": "4,4'-diaponeurosporenal + H2O + NAD(+) <=> 4,4'-diaponeurosporenoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190141", "l": "ALAD binds to Pb2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007467", "l": "The PRC1L4 complex binds the CDC7 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57143", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877153", "l": "STARD7 binds PC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71761", "l": "2-oxoglutarate(in) + heptanedioate(out) => 2-oxoglutarate(out) + heptanedioate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432295", "l": "GPVI binds Fyn and Lyn (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40421", "l": "3,7,11,15-tetramethylhexadecanoate + CoA + H(+) => H2O + phytanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69885", "l": "L-ascorbate(in) + 2 Na(+)(in) => L-ascorbate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52942", "l": "chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP => chenodeoxycholate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20746", "l": "15-oxoprostaglandin D2 + H(+) + NADPH => NADP(+) + prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48118", "l": "H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => L-arginyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807106", "l": "PTEN undergoes monoubiquitination (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20087", "l": "a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA => a flavonol 3-O-beta-D-glucoside + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30961", "l": "7,9,9'-tri-cis-neurosporene + a quinol => 9,9'-di-cis-zeta-carotene + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828023", "l": "Expression of POU5F1 (OCT4) in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11946", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+) => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43419", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174058", "l": "Degradation of multiubiquitinated Cdh1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59292", "l": "beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O = D-galactose + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28790", "l": "4-hydroxy-L-threonine + ATP <=> 4-(phosphooxy)-L-threonine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392513", "l": "Rap1 signal termination by Rap1GAPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509827", "l": "ITPA hydrolyses ITP to IMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.4", "l": "\"DNA 3'-5' helicase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43453", "l": "2 H(+) + hexanoyl-CoA + 2 malonyl-CoA => 4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9660557", "l": "RAS:GTP binds RAL GDS proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140571", "l": "transmembrane ascorbate ferrireductase activity", "d": ["Oxidation of Fe(3+) to Fe(2+) on the outer side of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.113", "l": "\"deoxyguanosine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004325", "l": "ferrochelatase activity", "d": ["Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5138432", "l": "DVL2 is phosphorylated by PKC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625416", "l": "Anterograde IFT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23026", "l": "[(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->4)-beta-D-glucosyl](n) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612440", "l": "ERBB4s80 binds the MXD4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.000891501185137", "identifiers": [{"i": "GO:0016667", "l": "oxidoreductase activity, acting on a sulfur group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47632", "l": "H2O + L-arginine + NAD(+) = 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796626", "l": "MIB2 ubiquitinates CFLAR  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61591", "l": "amicoumacin A + ATP <=> ADP + amicoumacin A 2-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380294", "l": "Loss of C-Nap-1 from centrosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14296", "l": "D-glucose + NAD(+) <=> D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0003857", "l": "3-hydroxyacyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24309", "l": "25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218821", "l": "PDK1 phosphorylates PKC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66676", "l": "(2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide = 4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22416", "l": "3,4-dihydroxybenzoate + H(+) = catechol + CO2", "d": []}, {"i": "EC:4.1.1.63", "l": "\"protocatechuate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-500717", "l": "Activation of GRIK3 homomer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050618", "l": "phycoerythrobilin:ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864729", "l": "PITX2 gene expression is stimulated by TFAP2A,TFAP2C homodimers:CITED2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37170", "l": "(2E,6E)-farnesol + NAD(+) <=> (2E,6E)-farnesal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981093", "l": "IL12 bound to IL12R internalises (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042958", "l": "maltodextrin transmembrane transporter activity", "d": ["Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981621", "l": "Neuroglobin:oxygen dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048273", "l": "mitogen-activated protein kinase p38 binding", "d": ["Binding to mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33282", "l": "L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905030", "l": "voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "d": ["Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805507", "l": "APAF1 binds AVEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46592", "l": "alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68444", "l": "5-cis-lycopene + O2 = (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.863640214551324", "identifiers": [{"i": "GO:0001848", "l": "complement binding", "d": ["Binding to a component or product of the complement cascade."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68556", "l": "NAD(+) + UDP-N-acetyl-alpha-D-quinovosamine = H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69005", "l": "3-amino-2-hydroxy-4-methoxybenzoate + ATP + nitrite => AMP + cremeomycin + diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-381109", "l": "IRE1 binds IRE1 forming dimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654544", "l": "Ligand-independent dimerization of overexpressed FGFR1c (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382061", "l": "Extracellular processing of novel PDGFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35801", "l": "7,8-dihydroneopterin 3'-phosphate + H(+) => 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102159", "l": "baicalein 7-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate + baicalein <=> H+ + UDP + baicalin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205056", "l": "PRDM4 inhibits cyclin E transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12806", "l": "(S)-canadine + S-adenosyl-L-methionine => (S)-cis-N-methylcanadine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56182", "l": "2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2 => 8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59810", "l": "D-tyrosine => L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033204", "l": "ribonuclease P RNA binding", "d": ["Binding to RNA subunit of ribonuclease P."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52986", "l": "6-carboxyhexanoyl-[ACP] + reduced [flavodoxin] => 7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66790", "l": "(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2 => N-methyl-L-dopa + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39716", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 => (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019163", "l": "pyridoxamine-phosphate transaminase activity", "d": ["Catalysis of the reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59364", "l": "1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50315", "l": "2-oxopentanoate + H(+) <=> butanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51223", "l": "1-chloro-2,4-dinitrobenzene + glutathione <=> 2,4-dinitrophenyl-S-glutathione + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64990", "l": "(R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+) => CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36590", "l": "an aldopyranose + NADP(+) <=> aldono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047697", "l": "beta-alanopine dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-beta-alanopine + H2O + NAD+ = beta-alanine + H+ + NADH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852317", "l": "PLK1 phosphorylates GTSE1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686587", "l": "ABL1 phosphorylates RAD52 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41316", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38182", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53508", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685605", "l": "SLAMF7 binds SLAMF7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75653", "l": "12,13-epoxy-(10R)-hydroxy-(8E,15Z)-octadecadienoate => (10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093342", "l": "SDC2 multimerises (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69677", "l": "(S)-eriodictyol + beta-D-glucose => eriodictyol-7-O-beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015180", "l": "L-alanine transmembrane transporter activity", "d": ["Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10524", "l": "2-oxoglutarate + H(+) = CO2 + succinate semialdehyde", "d": []}, {"i": "EC:4.1.1.71", "l": "\"2-oxoglutarate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706323", "l": "Active FLT3 binds to SLA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19870", "l": "an acyl-CoA + glycine => an N-acylglycine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8980691", "l": "RHOA GEFs activate RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19064", "l": "H2O + NADP(+) + nitrite <=> H(+) + NADPH + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44339", "l": "an L-alpha-amino acid + ATP + L-arginine <=> ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443831", "l": "14-3-3-zeta binds Raf1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679044", "l": "FKBP1A binds sirolimus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629497", "l": "NEIL3 cleaves thymine glycol from telomeric DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.147", "l": "\"acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10985", "l": "(S)-lactate + oxaloacetate => (S)-malate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46951", "l": "GTP + S-adenosyl-L-methionine <=> N(7)-methyl-GTP + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749215", "l": "MCM8 binds CDC6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602272", "l": "Defective CYP4F22 does not 20-hydroxylate TrXA3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5228992", "l": "ROCK1,ROCK2 are activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70596", "l": "GOT2 dimer deaminates L-Asp (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20517", "l": "UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine", "d": []}, {"i": "EC:5.1.3.7", "l": "\"UDP-N-acetylglucosamine 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36313", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADH => 3,4-dihydroxybenzaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19824", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396009", "l": "STING binds c-di-GMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23141", "l": "beta-nicotinamide D-ribonucleotide + H2O => D-ribose 5-phosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050108", "l": "monoterpenyl-diphosphatase activity", "d": ["Catalysis of the reaction: monoterpenyl diphosphate + H2O = monoterpenol + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009817", "l": "Acitretin binds to RAR:RXR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39425", "l": "(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070205", "l": "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity", "d": ["Catalysis of the reaction: 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382061", "l": "Extracellular processing of novel PDGFs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018482", "l": "4-formylbenzenesulfonate dehydrogenase activity", "d": ["Catalysis of the reaction: 4-formylbenzenesulfonate + H2O + NAD+ = 4-sulfobenzoate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19678", "l": "9'-cis-neoxanthin + O2 => (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198508", "l": "MDH1 oxidizes MAL to OA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870465", "l": "RGGT binds the RAB-binding subunit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55246", "l": "4beta-methylzymosterol-4alpha-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9704297", "l": "CHRM2 binds CHRM2 antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46568", "l": "5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682026", "l": "MRN bound to shortened telomeres activates ATM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13347", "l": "diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => (2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120286", "l": "tryptophan sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of tryptophan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52754", "l": "beta-D-glucose + D-glucose => H2O + isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156699", "l": "Inactivation of Wee1 kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47699", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O <=> (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48493", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose => 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68011", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (2E,6E,10E)-geranylgeranyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507870", "l": "Aquaporins passively transport water out of cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130194", "l": "ABL phosphorylates WAVEs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046180", "l": "KSPG is secreted from the cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27589", "l": "L-tryptophan + pyruvate <=> indole-3-pyruvate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3204303", "l": "MRE11 binds cytosolic DNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197770", "l": "STAB1 (FEEL-1) binds ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52509", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379982", "l": "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825555", "l": "RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.246", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54863", "l": "(2E)-geranial + H(+) + NADPH + O2 <=> (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193808", "l": "5beta-cholestan-3alpha,7alpha,27-triol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45649", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52852", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] = 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]", "d": []}, {"i": "EC:1.14.14.46", "l": "\"pimeloyl-[acyl-carrier protein] synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173725", "l": "C9 binds C5b:C6:C7:C8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810392", "l": "TMEM55B translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10418", "l": "2-benzylsuccinate => fumarate + toluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37161", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41192", "l": "1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60893", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O => a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45586", "l": "(2E)-butenoyl-CoA + H2O => 3-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001006", "l": "RNA polymerase III type 3 promoter sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13971", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + diphosphate + GMP => a 3'-end 3'-phospho-ribonucleotide-RNA + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37523", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67221", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA + NAD(+) => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.44", "l": "\"acyl-CoA (8-3)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18277", "l": "a thiol + S-adenosyl-L-methionine = a methyl thioether + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.9", "l": "\"thiol S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57020", "l": "apulose + ATP = ADP + apulose 4-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.233", "l": "\"apulose kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51164", "l": "cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45955", "l": "L-asparaginyl-[protein] + UDP-alpha-D-glucose <=> H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38292", "l": "(S)-malyl-CoA + H2O => (S)-malate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35561", "l": "menaquinol-7 + NAD(+) => H(+) + menaquinone-7 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50370", "l": "3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+) => 2-methylbutan-2-ol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63746", "l": "UDP + zolarsartan-1-N-beta-D-glucuronide => UDP-alpha-D-glucuronate + zolasartan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32036", "l": "(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O => (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36357", "l": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine => 4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54891", "l": "(1S,2S)-OPC-8 + ATP + CoA <=> AMP + diphosphate + OPC8-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10765", "l": "(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 => (4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848436", "l": "PTK6 phosphorylates CDKN1B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448963", "l": "Interaction of MyoD:E protein with MEF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67887", "l": "3'-phosphoadenylyl sulfate + dopamine <=> adenosine 3',5'-bisphosphate + dopamine 4-O-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10290", "l": "H(+) + L-rhamnonate => H2O + L-rhamnono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12696", "l": "3,4-dihydroxypyridine + O-acetyl-L-serine <=> 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70887", "l": "L-glutamine(in) + L-serine(out) + Na(+)(out) = L-glutamine(out) + L-serine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29883", "l": "ATP + H2O + L-ornithine(out) = ADP + H(+) + L-ornithine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10748", "l": "H(+) + hydrogencarbonate = CO2 + H2O", "d": []}, {"i": "EC:4.2.1.1", "l": "\"carbonic anhydrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40283", "l": "(R)-carnitine + hexadecanedioyl-CoA = CoA + O-hexadecanedioyl-L-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.14", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050396", "l": "vomifoliol 4'-dehydrogenase activity", "d": ["Catalysis of the reaction: (6S,9R)-6-hydroxy-3-oxo-alpha-ionol + NAD+ = (6S)-6-hydroxy-3-oxo-alpha-ionone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928624", "l": "EPHBs bind EFNBs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733754", "l": "Expression of MESP1 in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40717", "l": "1-hexadecanoylglycerone 3-phosphate + CoA => dihydroxyacetone phosphate + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432143", "l": "PECAM-1 binds PP2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388829", "l": "SHP2 phosphatase binds CTLA-4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17929", "l": "an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.138", "l": "\"ceramide kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374680", "l": "L1 trans-homophilic interaction (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203130", "l": "OLR1 binds to oxidized LDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21752", "l": "all-trans-violaxanthin = all-trans-capsorubin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37989", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol => delta-tocopherol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610735", "l": "NUMB binds ITCH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328048", "l": "Emilin is found in elastic fibres (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37206", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31752", "l": "chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662786", "l": "FURIN cleaves ADAM17 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0061922", "l": "histone propionyltransferase activity", "d": ["Catalysis of the reaction: propionyl-CoA + histone = CoA + propionyl-histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848335", "l": "IL37 binds  IL18R1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848110", "l": "SOCS3 binds activated PTK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75750", "l": "10-oxooctadecanoate + H(+) + NADH <=> 10-hydroxyoctadecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050110", "l": "mucinaminylserine mucinaminidase activity", "d": ["Catalysis of the reaction: D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196964", "l": "RFK:Mg2+ phosphorylates RIB (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33950", "l": "2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine <=> 2'-N-acetylparomamine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23335", "l": "(2R)-3-phosphoglycerate + GTP <=> (2R)-3-phospho-glyceroyl phosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130349", "l": "Generation of CLIP from lip10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390595", "l": "Calcium Binds Troponin-C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34642", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 <=> H2O + NADP(+) + neopentalenolactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46177", "l": "2-methylpropanoate + ATP + CoA => 2-methylpropanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61412", "l": "ATP + N-(D-erythrulosyl)-cadaverine = ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730904", "l": "Auto-ubiquitination of TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390674", "l": "ADRB1 bind ADR,NAd (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48719", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> 13-oxo-(9Z,11E)-octadecadienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804527", "l": "INTL1 binds bacterial glycans (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102155", "l": "S-sulfolactate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-sulfonatolactate + NAD <=> 3-sulfonatopyruvate(2-) + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29317", "l": "D-galactose + phosphate => alpha-D-galactose 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33283", "l": "2-hydroxycyclohexan-1-one + NADPH + O2 = 6-oxohexanoate + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.66", "l": "\"2-hydroxycyclohexanone 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75390", "l": "H2O + queuosine 5'-phosphate <=> D-ribose 5-phosphate + queuine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32829", "l": "ADP + H(+) + methionine(in) + phosphate => ATP + H2O + methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015640", "l": "peptidoglycan peptide transmembrane transporter activity", "d": ["Enables the transfer of peptidoglycan peptides from one side of a membrane to the other. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44337", "l": "an L-alpha-amino acid + ATP + L-arginine => ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33684", "l": "H(+) + L-serine + octadecanoyl-CoA => 3-oxoeicosasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38486", "l": "a 2,3-diacyl-sn-glycerol + H2O <=> a 2-acylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64422", "l": "H(+)(in) + L-alanyl-L-proline(in) => H(+)(out) + L-alanyl-L-proline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.139", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473594", "l": "Collagen type II degradation by MMP15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39059", "l": "26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2129362", "l": "Fibrillin microfibril assembly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10961", "l": "(S)-lactate => (R)-lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354289", "l": "AP-1:DSP1:STAT92E complex recruits RPD3 and represses transcription of the REL-68 target gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.n3", "l": "\"curcumin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58583", "l": "dihydroprecondylocarpine acetate <=> acetate + catharanthine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70280", "l": "H2O + stachyose => D-galactose + raffinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549129", "l": "OCT1 transports organic cations into hepatic cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63652", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.362", "l": "\"alpha-(1->3) branching sucrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24157", "l": "2-methylpropanoate + ATP => 2-methylpropanoyl phosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53560", "l": "9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22551", "l": "H2O + L-lysine + O2 <=> (S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033438", "l": "ACC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an ACC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855111", "l": "VLDLR binds PCSK9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43362", "l": "an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP => an N-acylsphinganine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14420", "l": "acetyl phosphate + L-lysine <=> H(+) + N(6)-acetyl-L-lysine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.102", "l": "\"blood-group-substance endo-1,4-beta-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28568", "l": "6 AMP + enterobactin + 7 H(+) => 3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985293", "l": "NKX3-2 binds RUNX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878056", "l": "RUNX1:CBFB binds EP300 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613497", "l": "Unwinding DNA for the nascent transcript (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.16.1", "l": "\"spleen exonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604752", "l": "Initial activation of proMMP13 by MMP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-376884", "l": "glucose 6-phosphate [cytosol] => glucose 6-phosphate [endoplasmic reticulum lumen] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27312", "l": "2-hydroxychromene-2-carboxylate + H(+) => naphthalene-1,2-diol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25678", "l": "ATP + O-phospho-L-serine + tRNA(Cys) = AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)", "d": []}, {"i": "EC:6.1.1.27", "l": "\"O-phosphoserine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54674", "l": "(+)-kolavelool + diphosphate => (+)-kolavenyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20817", "l": "3alpha-hydroxyglycyrrhetinate + NADP(+) => 3-oxoglycyrrhetinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371435", "l": "Constitutive phosphorylation by GSK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15054", "l": "(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75828", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] => (5S,18)-dihydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59536", "l": "ATP + butanoyl-CoA + hydrogencarbonate = (2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60165", "l": "a guanosine in RNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70671", "l": "N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833671", "l": "CDH11 forms heterotypic trans dimer with CDH24 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708557", "l": "FBXL17 binds BACH1:MAFK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34610", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine <=> a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11758", "l": "AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein] => ATP + biotin + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21034", "l": "acceptor beta-D-glucuronoside + H(+) + UDP => glucuronate acceptor + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710254", "l": "GSDME oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070636", "l": "nicotinic acid riboside hydrolase activity", "d": ["Catalysis of the reaction: nicotinic acid riboside + H2O = nicotinic acid + D-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15404", "l": "a dolichyl phosphate + UDP-alpha-D-glucose <=> a dolichyl beta-D-glucosyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43374", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+) => an N-acylsphing-4-enine + dTDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139919", "l": "Translocation of BIM to mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702818", "l": "CALCR binds erenumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37447", "l": "O2 + tetracenomycin F1 = H(+) + H2O + tetracenomycin D3", "d": []}, {"i": "EC:1.13.12.21", "l": "\"tetracenomycin-F1 monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17468", "l": "H2O + quercitrin <=> L-rhamnopyranose + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16566", "l": "2-oxoglutarate + L-histidine => 3-(imidazol-5-yl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36163", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate", "d": []}, {"i": "EC:6.3.4.21", "l": "\"nicotinate phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606807", "l": "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70814", "l": "4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde 3-phosphate <=> D-xylulose 5-phosphate + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73577", "l": "CAD hexamer transforms L-Gln to CAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35945", "l": "deoxybrevianamide E + diphosphate => brevianamide F + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25444", "l": "(2E,6E)-farnesyl diphosphate = (1E,4E)-germacrene B + diphosphate", "d": []}, {"i": "EC:4.2.3.71", "l": "\"(E,E)-germacrene B synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75995", "l": "3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57544", "l": "(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": []}, {"i": "EC:1.14.14.160", "l": "\"zealexin A1 synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.89", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58624", "l": "N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75319", "l": "chloride(out) + D-alanine(out) + 2 Na(+)(out) = chloride(in) + D-alanine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49047", "l": "H(+) + NADH + O2 + protoasukamycin <=> 4-hydroxyprotoasukamycin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031530", "l": "gonadotropin-releasing hormone receptor binding", "d": ["Binding to a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624952", "l": "Assembly of the retrograde IFT train (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013108", "l": "GDIs block activation of RHOC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.46", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71301", "l": "chloride(in) + L-isoleucine(in) + 2 Na(+)(in) => chloride(out) + L-isoleucine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956676", "l": "YAP1 binds TP73 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18607", "l": "1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+) => 1-amino-1-deoxy-scyllo-inositol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004666", "l": "prostaglandin-endoperoxide synthase activity", "d": ["Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69671", "l": "(2S)-naringenin 7-O-beta-D-glucoside + H2O = (2S)-naringenin + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55379", "l": "2 a quinol + O2 <=> 2 a quinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106314", "l": "nitrite reductase NADPH activity", "d": ["Catalysis of the reaction: ammonium hydroxide + 3 NADP+ + H2O = nitrite + 3 NADPH + 3 H+."]}, {"i": "RHEA:24632", "l": "2 H2O + 3 NADP(+) + NH4(+) = 5 H(+) + 3 NADPH + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73957", "l": "4-ethylcatechol + NAD(+) => 3,4-dihydroxystyrene + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57961", "l": "dimethyl sulfide + H(+) + NADH + O2 => dimethyl sulfoxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53445", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710106", "l": "ELANE cleaves GSDMD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102054", "l": "maleylpyruvate hydrolase activity", "d": ["Catalysis of the reaction: 3-maleylpyruvate(2-) + H2O <=> H+ + maleate(2-) + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031013", "l": "troponin I binding", "d": ["Binding to troponin I, the inhibitory subunit of the troponin complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002428", "l": "Removal of fibrillar collagen N-propeptides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444433", "l": "Cho transports from the extracellular space to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42123", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195304", "l": "Association of beta-catenin with the destruction complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0070330", "l": "aromatase activity", "d": ["Catalysis of the reduction of an aliphatic ring to yield an aromatic ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32264", "l": "4-aminobutanoate + pyruvate => L-alanine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39300", "l": "(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.168", "l": "\"xyloglucan 4-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419645", "l": "Dimerization of LIMK1 by Hsp90 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36368", "l": "(S)-alpha-hydroxyglutarate-gamma-lactone + H2O => 2-hydroxyglutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60911", "l": "a cytidine in tRNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39791", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679029", "l": "C-ter TLR7 dimer binds HCQ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8869683", "l": "oxPL binds LBP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28163", "l": "cytidine + GTP => CMP + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63769", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5684140", "l": "ATM phosphorylates RBBP8 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42071", "l": "(3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH <=> clavulanate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59074", "l": "5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26426", "l": "ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate", "d": []}, {"i": "EC:6.3.4.2", "l": "\"CTP synthase (glutamine hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050467", "l": "pentalenene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + pentalenene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70367", "l": "3-oxosphinganine + octanoyl-CoA = CoA + H(+) + N-octanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72444", "l": "(E)-feruloyl-AMP + CoA => (E)-feruloyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42913", "l": "cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65323", "l": "2-oxoglutarate + chrodrimanin E + O2 <=> chrodrimanin A + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54539", "l": "a very long-chain fatty acid + ATP + CoA <=> a very long-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72579", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O = (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647978", "l": "pro-RAS proteins are farnesylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65481", "l": "2-methylbutanoyl-CoA + hexan-1-ol => CoA + hexyl 2-methylbutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848077", "l": "PTK6 phosphorylates STAP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-877281", "l": "PIAS1 binds p-STAT1 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70095", "l": "(R)-5-methyl-tetronate + o-quinone methide = peniphenone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12741", "l": "ADP + H(+) + H2O = IDP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29853", "l": "2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP => H2O + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12563", "l": "hydroquinone + UDP-alpha-D-glucose <=> H(+) + hydroquinone O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68966", "l": "2-oxooctadecanoate + H2O2 => 2-hydroxyoctadecanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5631885", "l": "PRDX1 overoxidizes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019911", "l": "structural constituent of myelin sheath", "d": ["The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23788", "l": "acetate + ATP + holo-[citrate lyase ACP] = acetyl-[citrate lyase ACP] + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.22", "l": "\"[citrate (pro-3S)-lyase] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40563", "l": "dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 = dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614461", "l": "Tetramerization of procollagen VI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047954", "l": "glycerol-2-phosphatase activity", "d": ["Catalysis of the reaction: glycerol 2-phosphate + H2O = glycerol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12678", "l": "AH2 + Latia luciferin + 2 O2 => A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20202", "l": "ATP + H2O + L-phenylalanine => AMP + D-phenylalanine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110215", "l": "Cleavage of uracil by UNG glycosylase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53048", "l": "2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21260", "l": "[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (R)-S-oxide", "d": []}, {"i": "EC:1.8.4.14", "l": "\"L-methionine (R)-S-oxide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0097200", "l": "cysteine-type endopeptidase activity involved in execution phase of apoptosis", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63486", "l": "CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein] => 2-oxoglutarate + L-prolyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809521", "l": "BPIF binds bacteria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689649", "l": "BAP1 binds BRCA1:BARD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013979", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27476", "l": "ATP + D-glycero-beta-D-manno-heptose 7-phosphate <=> ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195726", "l": "Association of  NA into rafts (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166792", "l": "Conversion of C2 into C2a and C2b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61537", "l": "ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620456", "l": "sGC stimulators bind sGC:NO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689317", "l": "Formation of the pre-incision complex in GG-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63058", "l": "5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine => acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61577", "l": "(4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+) => (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42700", "l": "6-carboxyhexanoyl-[ACP] methyl ester + H2O = 6-carboxyhexanoyl-[ACP] + H(+) + methanol", "d": []}, {"i": "EC:3.1.1.85", "l": "\"pimeloyl-[acyl-carrier protein] methyl ester esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195275", "l": "Phosphorylation of APC component of the destruction complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9620456", "l": "sGC stimulators bind sGC:NO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73352", "l": "ATP + beta-alanine + histamine => AMP + carcinine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168640", "l": "Ubiquitinated IkB is degraded (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22641", "l": "NADP(+) + sphinganine => 3-oxosphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33122", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-sativene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37881", "l": "aklaviketone => methyl aklanonate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050591", "l": "quinine 3-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + quinine = 3-hydroxyquinine + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858252", "l": "HDLBP binds HDL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17860", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56915", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) <=> (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810376", "l": "ING2 binds PI5P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373748", "l": "SEMA4D interacts with CD72 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989746", "l": "Expression of CYP7A1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4411373", "l": "NLK translocates to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30270", "l": "2 monodehydro-L-ascorbate radical <=> L-ascorbate + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38835", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70830", "l": "tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12360", "l": "(2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine = 13-(2-methylcrotonoyloxy)lupanine + CoA", "d": []}, {"i": "EC:2.3.1.93", "l": "\"13-hydroxylupanine O-tigloyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35592", "l": "H2 + n sulfur => H(+) + hydrogen sulfide + (n-1) sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54831", "l": "dimethylamine + H(+) + NADPH + O2 <=> formaldehyde + H2O + methylamine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51284", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate = (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714691", "l": "RAC3 binds ER effectors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31024", "l": "squalene => dammara-20,24-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551648", "l": "SUMOylation of TDG with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67654", "l": "2'-deoxyadenosine + diphosphate => dADP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166214", "l": "FA anion flip-flops to the opposite surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67951", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose <=> 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34386", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose <=> beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196857", "l": "PANK2 phosphorylates PanK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56536", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47529", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isocholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683672", "l": "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9796617", "l": "MIB2 binds CFLAR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51578", "l": "H(+) + phlorizin + UDP => phloretin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13868", "l": "GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol <=> beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41835", "l": "(2E)-hexenoyl-[ACP] + H(+) + NADPH <=> hexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209112", "l": "Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34473", "l": "acryloyl-CoA + H(+) + NADH => NAD(+) + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140393", "l": "norsolorinic acid ketoreductase activity", "d": ["Catalysis of the reaction: (1'S)-averantin + NADP+ <=> norsolorinic acid + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981892", "l": "Active G alpha (z) binds RGS proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69060", "l": "N(delta)-hydroxy-N(omega)-methyl-L-arginine + NADH + O2 = H2O + N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46870", "l": "a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB (E. coli) => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174121", "l": "Association of Securin with Cdc20:APC/C complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424484", "l": "Phosphorylation of BTK by p-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785594", "l": "FANCD2 binds FANCI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14848", "l": "L-aspartate 4-semialdehyde + pyruvate <=> (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781899", "l": "USP13 binds SIAH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41427", "l": "2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2 <=> formate + grixazone A + H(+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64778", "l": "2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol => 3-sulfanylpentan-1-ol-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59009", "l": "H2O + O2 + salicylaldehyde => H(+) + H2O2 + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30870", "l": "H2O + indole-3-acetaldehyde + NAD(+) <=> (indol-3-yl)acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18145", "l": "ATP + beta-D-fructose = ADP + beta-D-fructose 1-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.3", "l": "\"ketohexokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005521", "l": "lamin binding", "d": ["Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0036469", "l": "L-tryptophan decarboxylase activity", "d": ["Catalysis of the reaction: L-tryptophan + H+ = CO2 + tryptamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37558", "l": "D-kanosamine 6-phosphate + H2O <=> kanosamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50603", "l": "acetyl-CoA + N-terminal L-seryl-[histone H2A] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668395", "l": "CHMP7 binds CC2D1B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65384", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16239", "l": "[protein]-peptidylproline (omega=0) => [protein]-peptidylproline (omega=180)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55880", "l": "apo-[aequorin]--coelenterazine + O2 = [aequorin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50174", "l": "N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50442", "l": "prostaglandin D1 => prostaglandin H1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14642", "l": "cyanurate + H2O => biuret + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-706479", "l": "TAK1 is activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674019", "l": "BRAP binds KSR1:MARK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218642", "l": "PTK2 autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140769", "l": "factor VII -> factor VIIa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781953", "l": "YOD1 binds VCP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008879", "l": "glucose-1-phosphate thymidylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062213", "l": "peroxynitrite isomerase activity", "d": ["Catalysis of the reaction: peroxynitrite = nitrate."]}, {"i": "RHEA:63116", "l": "peroxynitrite = nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218815", "l": "p-6Y-VEGFR2 binds NCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65333", "l": "H(+) + NADPH + O2 + verruculide A => chrodrimanin E + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52354", "l": "(24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43686", "l": "AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45592", "l": "H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67235", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA + NAD(+) <=> (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51398", "l": "CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11056", "l": "4-aminobenzoate + 2 H(+) + NADPH + O2 = 4-aminophenol + CO2 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42022", "l": "H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone => 11-dehydrocorticosterone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10031", "l": "D-glutamate + H2O + O2 <=> 2-oxoglutarate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53474", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51862", "l": "8-geranylumbelliferone + diphosphate => (2E)-geranyl diphosphate + umbelliferone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734687", "l": "ORC6 is phosphorylated on T195 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71279", "l": "chloride(out) + L-leucine(out) + 2 Na(+)(out) = chloride(in) + L-leucine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34443", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)", "d": []}, {"i": "EC:2.3.1.210", "l": "\"dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665748", "l": "FMNL2 binds RHOC:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420977", "l": "Ca permeable AMPA receptor ligand binding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086083", "l": "SUMOylation of ING2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20107", "l": "AMP + beta-D-fructose 1,6-bisphosphate + H(+) => ADP + beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.38", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37437", "l": "a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2509831", "l": "ITPA hydrolyses XTP to XMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57435", "l": "3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] <=> 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47505", "l": "chenodeoxycholate + NADP(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14561", "l": "(E,E)-piperoyl-CoA + piperidine = CoA + H(+) + piperine", "d": []}, {"i": "EC:2.3.1.145", "l": "\"piperidine N-piperoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870558", "l": "CDK5:p25 phosphorylates FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13816", "l": "benzene + H(+) + NADH + O2 <=> cis-1,2-dihydrobenzene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37051", "l": "3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11364", "l": "ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate", "d": []}, {"i": "EC:2.7.9.2", "l": "\"pyruvate, water dikinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17506", "l": "H2O + N-(long-chain fatty acyl)ethanolamine => a long-chain fatty acid + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433957", "l": "Activation of recruited TAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67452", "l": "a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)", "d": []}, {"i": "EC:3.1.1.117", "l": "\"(4-O-methyl)-D-glucuronate--lignin esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140376", "l": "innate immune receptor activity", "d": ["Receiving a signal and transmitting it in a cell to initiate an innate immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23407", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate <=> diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44892", "l": "an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose = an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870461", "l": "RABGGTA and RABGGTB bind (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3341294", "l": "Superoxide reduces cytochrome c (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14048", "l": "1-carboxyvinyl carboxyphosphonate + H(+) <=> 3-(hydrohydroxyphosphoryl)pyruvate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32335", "l": "(1S,2S,4R)-endo-fenchol + NADP(+) = (1S,4R)-fenchone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25480", "l": "acetoacetate + succinyl-CoA = acetoacetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56068", "l": "an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696670", "l": "CHD1L is recruited to GG-NER site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16299", "l": "17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH => 5alpha-androstane-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70226", "l": "(2S)-2-aminobutanoate + 2-oxoglutarate <=> 2-oxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72586", "l": "(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+) <=> 3,22-dioxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9617927", "l": "FOXO4 binds ATXN3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73531", "l": "CTP(out) + UTP(in) = CTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33607", "l": "(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876472", "l": "NPC2 binds CHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132210", "l": "C3b fragment binds to the target cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046998", "l": "(S)-usnate reductase activity", "d": ["Catalysis of the reaction: (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD+ = (S)-usnate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11864", "l": "H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine = dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.5.8.2", "l": "\"trimethylamine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420128", "l": "SRC-1 phosphorylates SHB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42750", "l": "5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(967) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.17", "l": "\"enoyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693111", "l": "RHOF auto-activates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52904", "l": "15,17(3)-seco-F430-17(3)-acid + ATP = ADP + coenzyme F430 + phosphate", "d": []}, {"i": "EC:6.4.1.9", "l": "\"coenzyme F430 synthetase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38671", "l": "sphinganine 1-phosphate(in) = sphinganine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018504", "l": "cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030346", "l": "protein phosphatase 2B binding", "d": ["Binding to a protein phosphatase 2B."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847968", "l": "PTEN binds FRK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.938386572175233", "identifiers": [{"i": "GO:0052742", "l": "phosphatidylinositol kinase activity", "d": ["Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514831", "l": "Fibrillin-1 degradation by MMP14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14299", "l": "an N-acylsphing-4-enine + D-galactose => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27560", "l": "(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate => all-trans-hexaprenyl diphosphate + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5615668", "l": "AKR1C3 reduces atRAL to atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419334", "l": "Melatonin receptors can bind melatonin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226016", "l": "Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50240", "l": "[hyaluronan](n) = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O", "d": []}, {"i": "EC:4.2.2.1", "l": "\"hyaluronate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449117", "l": "TXLNA (IL14) binds syntaxin1A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17033", "l": "(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) = biphenyl-2,3-diol + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.56", "l": "\"cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72511", "l": "(R)-carnitine(out) + 2-oxoglutarate(in) = (R)-carnitine(in) + 2-oxoglutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677050", "l": "Formation of the GCN5-ATAC complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706304", "l": "Active FLT3 binds to GRAP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9639286", "l": "RRAGC,D exchanges GTP for GDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70219", "l": "corticosterone + H(+) + NADPH = 20beta-dihydrocorticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32608", "l": "(6E)-8-hydroxygeraniol + NADP(+) => (6E)-8-hydroxygeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49720", "l": "2 H(+) + NADH + 2 O2 + protoviolaceinate = CO2 + 2 H2O + NAD(+) + violacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45166", "l": "2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177923", "l": "Sustained activation of SRC kinase by SHP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16139", "l": "3''-deamino-3''-oxonicotianamine + H(+) + NADPH => 2'-deoxymugineate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980067", "l": "NOTCH1 stimulates MYC transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203973", "l": "Vesicle budding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682967", "l": "WHSC1 binds DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40100", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA => 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24265", "l": "D-xylulose 5-phosphate + formaldehyde => D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44773", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 => 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61055", "l": "(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59786", "l": "(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH => H2O + NADP(+) + pseudopaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18963", "l": "H2O + N(6)-(D-psicosyl)-L-lysyl-[protein] => D-allose + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34249", "l": "1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH => 1-deoxymethyl-sphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627107", "l": "XIAP binds CASP7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089715", "l": "tRNA m6t6A37 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing N6-threonylcarbamoyladenosine = S-adenosyl-L-homocysteine + tRNA containing N6-methylthreonylcarbamoyladenosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13497", "l": "5-dehydro-2-deoxy-D-gluconate + ATP = 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.92", "l": "\"5-dehydro-2-deoxygluconokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15460", "l": "cis-1,2-dihydrobenzene-1,2-diol + NAD(+) <=> catechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11522", "l": "(-)-menthyl beta-D-glucoside + H(+) + UDP => (-)-menthol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.73", "l": "\"adenosylcobalamin/alpha-ribazole phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734730", "l": "ORC1 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799466", "l": "TP53I3 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940134", "l": "FOLR2 binds FOLA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20942", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4-trisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62402", "l": "(S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1R,2S)-ephedrine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11215", "l": "indole + O2 <=> 2-formamidobenzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48873", "l": "a gentamycin + GTP => a gentamycin 2''-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800298", "l": "HGF dimer binds MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24016", "l": "16-epivellosimine + acetyl-CoA = CoA + vinorine", "d": []}, {"i": "EC:2.3.1.160", "l": "\"vinorine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50092", "l": "a fatty acyl-CoA + taurine = an N-fatty acyl-taurine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875531", "l": "MET binds TNS4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602473", "l": "Autocatalytic activation of MMP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24524", "l": "20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.34", "l": "\"20-oxo-5-O-mycaminosyltylactone 23-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112703", "l": "PTPN11 is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030170", "l": "pyridoxal phosphate binding", "d": ["Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362522", "l": "ALDHs oxidise atRAL to atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727819", "l": "TAK1 phosphorylates MKK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0047429", "l": "nucleoside triphosphate diphosphatase activity", "d": ["Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16478", "l": "NAD(+) + prostaglandin E1 => 15-oxoprostaglandin E1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218836", "l": "PTK2beta binds alphaVbeta3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046507", "l": "UDPsulfoquinovose synthase activity", "d": ["Catalysis of the reaction: sulfite + UDP-D-glucose = H2O + UDP-6-sulfoquinovose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375151", "l": "Interaction of NCAM1 with collagens (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43801", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12934", "l": "L-fuculose 1-phosphate => (S)-lactaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45289", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 => 2-glyceryl-prostaglandin G2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417898", "l": "P2Y4 receptor can bind to UTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49425", "l": "ATP + validone => ADP + H(+) + validone 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201611", "l": "Caspase-mediated cleavage of Rock-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36587", "l": "an aldopyranose + NADP(+) = aldono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158357", "l": "factor XIIa binds SERPING1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59246", "l": "acetate + ADP-D-ribose + H(+) => 3''-O-acetyl-ADP-D-ribose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59646", "l": "D-xylobionate + H(+) => D-xylobiono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32748", "l": "ethanolamine(in) => ethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015383", "l": "sulfate:bicarbonate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + bicarbonate(in) = sulfate(in) + bicarbonate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27334", "l": "6-hydroxynicotinate + 2 H(+) + NADH + O2 => 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71230", "l": "2 Na(+)(out) + selenocyanate(out) <=> 2 Na(+)(in) + selenocyanate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28874", "l": "D-fructuronate(in) + H(+)(in) <=> D-fructuronate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31984", "l": "abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168862", "l": "Association of HA into rafts (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20843", "l": "H(+) + L-histidine <=> CO2 + histamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25648", "l": "(2R,5R)-isomenthone + NADP(+) <=> (R)-pulegone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21878", "l": "(S)-usnate + 2 H(+) + NADH => (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168038", "l": "Collagen type XV restin release (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45970", "l": "9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+) => androst-4-ene-3,17-dione + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27762", "l": "CTP + H2O = CMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22325", "l": "H2O + leukotriene A4 => leukotriene B4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4608855", "l": "PRICKLE1 is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000248", "l": "C-5 sterol desaturase activity", "d": ["Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21733", "l": "chorismate + L-glutamine => anthranilate + H(+) + L-glutamate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450975", "l": "isocitrate <=> citrate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68289", "l": "heptanoyl-CoA + L-seryl-[protein] => CoA + O-heptanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109862", "l": "MAP2K2 phosphorylates MAPK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031781", "l": "type 3 melanocortin receptor binding", "d": ["Binding to a type 3 melanocortin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51721", "l": "ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32100", "l": "S-adenosyl-L-methionine + TRIBOA beta-D-glucoside => DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811412", "l": "Active ARF recruits coatomer to the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11001", "l": "an N-carbamoyl-D-amino acid + 2 H(+) + H2O => a D-alpha-amino acid + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58763", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53171", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33022", "l": "(3S)-3,6-diaminohexanoate + acetyl-CoA <=> (3S)-6-acetamido-3-aminohexanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2464822", "l": "RDH12 reduces atRAL to atROL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11759", "l": "ATP + biotin + L-lysyl-[protein] <=> AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008791", "l": "arginine N-succinyltransferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665389", "l": "Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32379", "l": "(1R,2R,4S)-limonene-1,2-diol + NAD(+) = (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682598", "l": "ATM phosphorylates HERC2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26160", "l": "(S)-2,3-epoxysqualene = thalianol", "d": []}, {"i": "EC:5.4.99.31", "l": "\"thalianol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46530", "l": "(5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64981", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168849", "l": "tBID binds to inactive BAX protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870465", "l": "RGGT binds the RAB-binding subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27740", "l": "2-deoxy-alpha-D-ribose 1-phosphate + guanine => 2'-deoxyguanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755304", "l": "MUL1 ubiquitinates UBXN7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0034347", "l": "type III interferon binding", "d": ["Binding to a type III interferon. Interferon lambda is the only member of the type III interferon found so far."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44504", "l": "4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16085", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17661", "l": "ATP + CoA + succinate = ADP + phosphate + succinyl-CoA", "d": []}, {"i": "EC:6.2.1.5", "l": "\"succinate--CoA ligase (ADP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54582", "l": "a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+) => a 5'-end dephospho-ribonucleoside-RNA + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27797", "l": "(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate <=> all-trans-heptaprenyl diphosphate + 4 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44777", "l": "2-demethylmenaquinol-6 + S-adenosyl-L-methionine => H(+) + menaquinol-6 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35520", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662619", "l": "MT1H binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102440", "l": "3',4',5'-trimethylmyricetin 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5'-trimethylmyricetin + S-adenosyl-L-methionine <=> 3,3',4',5'-tetramethylmyricetin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49618", "l": "2-hydroxy-2-methylpropanoate + 2 H(+) + NADH => 2-hydroxy-2-methylpropanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19384", "l": "(S)-oxalosuccinate + H(+) <=> 2-oxoglutarate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071794", "l": "CAP-Gly domain binding", "d": ["Binding to a CAP-Gly domain of a protein. The CAP_Gly domain is a conserved, glycine-rich domain of about 42 residues found in some cytoskeleton-associated proteins, and features a novel protein fold containing three beta-sheets."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70017", "l": "7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2984226", "l": "PLK1 phosphorylates NEK9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168459", "l": "Lyn activates ERK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26471", "l": "(E)-feruloyl-CoA + 16-hydroxyhexadecanoate => 16-feruloyloxyhexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62511", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004772", "l": "sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50755", "l": "2 naphthalene-1,2,4,8-tetrol + O2 <=> 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983700", "l": "SYK binds the activated BCR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683720", "l": "E protein gets palmitoylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173739", "l": "Spontaneous hydrolysis of C3 thioester (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27436", "l": "2 glutathione amide + NAD(+) <=> glutathione amide disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702589", "l": "gilteritinib-resistant FLT3 mutants don't bind gilteritinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52849", "l": "5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine => 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38221", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004156", "l": "dihydropteroate synthase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008684", "l": "TBK1 phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74951", "l": "(3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + 2-oxoglutarate + O2 = (3R)-3-isocyanylbutanoate + 2 CO2 + 2 H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32724", "l": "L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12593", "l": "a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.5", "l": "\"CDP-diacylglycerol--glycerol-3-phosphate 1-phosphatidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24460", "l": "H(+) + malonyl-[ACP] = acetyl-[ACP] + CO2", "d": []}, {"i": "EC:4.1.1.87", "l": "\"malonyl-S-ACP decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102480", "l": "5-fluorocytosine deaminase activity", "d": ["Catalysis of the reaction: H+ + flucytosine + H2O <=> 5-fluorouracil + ammonium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805785", "l": "AKT phosphorylates PHF20 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033851", "l": "lavandulyl diphosphate synthase activity", "d": ["Catalysis of the reaction: 2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63696", "l": "SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2250301", "l": "Formation of lysyl-pyrrole cross-links (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13614", "l": "beta-D-fructose 6-phosphate + diphosphate => beta-D-fructose 1,6-bisphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928614", "l": "EFNB:GRB4 binds GIT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031725", "l": "CXCR6 chemokine receptor binding", "d": ["Binding to a CXCR6 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683831", "l": "CCDC59 binds TTF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70878", "l": "L-glutamine(in) + L-methionine(out) + Na(+)(out) <=> L-glutamine(out) + L-methionine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64489", "l": "acetyl-CoA + 5 H(+) + holo-[ACP] + 5 malonyl-CoA => 3,5,7,9,11-pentaoxododecanoyl-[ACP] + 5 CO2 + 6 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53235", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28902", "l": "glycine(in) + H(+)(in) <=> glycine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54056", "l": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-hedycaryol + diphosphate", "d": []}, {"i": "EC:4.2.3.174", "l": "\"(2E,6E)-hedycaryol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28804", "l": "H2O + L-ascorbate 6-phosphate => 3-dehydro-L-gulonate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55451", "l": "a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332363", "l": "Autophosphorylation and activation of CAMK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37120", "l": "7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine => 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50744", "l": "2 glyphosate + O2 = 2 aminomethylphosphonate + 2 glyoxylate + 2 H(+)", "d": []}, {"i": "EC:1.5.3.23", "l": "\"glyphosate oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49584", "l": "D-erythrulose 1-phosphate = L-erythrulose 1-phosphate", "d": []}, {"i": "EC:5.1.3.38", "l": "\"D-erythrulose 1-phosphate 3-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749197", "l": "ORC1 binds to H4K20me2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42410", "l": "(2R)-2,3-bisphosphoglycerate + ADP + H(+) => (2R)-2-phosphoglycerate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12732", "l": "lutein <=> (3R,3'S)-zeaxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59248", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA = (E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2545196", "l": "FN1 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72146", "l": "AH2 + GTP + S-adenosyl-L-methionine <=> 3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42695", "l": "[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate <=> [(1->4)-alpha-D-glucosyl](n+2) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47616", "l": "ethionamide + H(+) + NADPH + O2 = ethionamide S-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63861", "l": "(9Z,12Z)-octadecadienoate + O2 => (2R,9Z,12Z)-2-hydroperoxyoctadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55384", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate = 6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37428", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate => a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018577", "l": "catechol 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: catechol + O2 = 2-hydroxymuconate semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52809", "l": "adenosine in U6 snRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10093", "l": "a 2'-deoxyribonucleoside 3'-phosphate + H2O => a 2'-deoxyribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49357", "l": "2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58635", "l": "N-tetradecanoyl-(2S)-hydroxyglycine <=> glyoxylate + tetradecamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30897", "l": "3-aminopropanal + H2O2 + NH4(+) => H2O + O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27500", "l": "3'-O-methyltricetin + S-adenosyl-L-methionine <=> 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693356", "l": "CEMIP hydrolyses HA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52387", "l": "L-glutamate + O-phospho-L-serine <=> H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10983", "l": "L-serine <=> D-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.41", "l": "\"atrolysin B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74520", "l": "1-(3-O-sulfo-beta-D-galactosyl)-ceramide + H2O => beta-D-Gal-(1<->1')-Cer + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798372", "l": "ATM phosphorylates DYRK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46094", "l": "(25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20649", "l": "23,24-dihydrocucurbitacin B + NADP(+) = cucurbitacin B + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873926", "l": "IFNG dimer binds IFNGR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168046", "l": "Collagen type XII degradation by MMP12 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696268", "l": "RND3 binds effectors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5444511", "l": "Formation of MSH2:MSH3 Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17188", "l": "IMP + NADP(+) + NH4(+) <=> GMP + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9669854", "l": "KIT binds type II TKIs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2995388", "l": "PP2A dephosphorylates BANF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10780", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66348", "l": "3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A = (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798373", "l": "MDM2 ubiquitinates DYRK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043957", "l": "acryloyl-CoA reductase (NADP+) activity", "d": ["Catalysis of the reaction: acryloyl-CoA + NADPH + H+ = propionyl-CoA + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186798", "l": "GAP binds to PDGF-beta receptors only (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74730", "l": "Insulin degradation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026757", "l": "GGT hydrolyses MCTR1 to MCTR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430183", "l": "NCK binds PAK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38268", "l": "2-methylfumaryl-CoA => 3-methylfumaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24694", "l": "(E)-isoeugenol + acetate + NADP(+) = (E)-coniferyl acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51269", "l": "norbelladine + S-adenosyl-L-methionine => 4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72530", "l": "1-hydroxy-6-methoxyphenazine + S-adenosyl-L-methionine <=> 1,6-dimethoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045437", "l": "uridine nucleosidase activity", "d": ["Catalysis of the reaction: H2O + uridine = ribofuranose + uracil."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422454", "l": "Polysialylation of NCAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166869", "l": "TRAF6 binds MEKK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37670", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16242", "l": "an NDP-alpha-D-glucose + D-fructose => a ribonucleoside 5'-diphosphate + H(+) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.9", "l": "\"Xaa-Pro aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64985", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68802", "l": "alpha-D-glucose + D-glucose => H2O + nigerose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950778", "l": "p-Y693-STAT4 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50007", "l": "H(+) + NADPH + O2 + tetracycline <=> 11a-hydroxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166082", "l": "IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75172", "l": "Formation of RAD50:MRE11 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22371", "l": "L-ribulose 5-phosphate <=> D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848338", "l": "PNPLA4 hydrolyzes TAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033520", "l": "TYSND1 cleaves TYSND1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951486", "l": "CD46 binds C4b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851890", "l": "MET phosphorylates SHC1-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796617", "l": "MIB2 binds CFLAR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433488", "l": "Phosphorylation of SHP2 by SFKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39098", "l": "(3S)-hydroxydecanedioyl-CoA + NAD(+) <=> 3-oxodecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70021", "l": "7-oxatyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + typhasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786567", "l": "KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196929", "l": "FLAD1 phosphorylates FMN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16482", "l": "3 S-adenosyl-L-methionine => 3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42249", "l": "butanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxohexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51731", "l": "dihydroxyacetone phosphate + H2O <=> dihydroxyacetone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62934", "l": "acetate + cytidine + H(+) => H2O + N(4)-acetylcytidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730882", "l": "Phosphorylation of PKC-theta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24166", "l": "[thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein] => [thioredoxin]-disulfide + H2O + L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10667", "l": "NAD(+) + perillyl alcohol <=> H(+) + NADH + perillyl aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018713", "l": "3-ketopimelyl-CoA thiolase activity", "d": ["Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70426", "l": "an acyl-CoA + H2O <=> a carboxylate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611277", "l": "P2RY12 binds P2RY12 antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53099", "l": "4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39927", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950322", "l": "Expression of ribosomal protein lateral stalk subunit P0 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60357", "l": "H2O + N-octanoylanthranilate => anthranilate + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22311", "l": "O2 + xylitol <=> D-xylose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30054", "l": "fluoroacetate + H2O <=> fluoride + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814153", "l": "ADO oxidises 2AET to HTAU (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666046", "l": "SRF:MKL1 binds ITGB1 Gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45351", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193677", "l": "NRIF binds to p75NTR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084507", "l": "Laminin-111 binds endostatin dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675194", "l": "Activated MAPK phosphorylates RAF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33749", "l": "a 1-acyl-sn-glycero-3-phosphate + ADP + H(+) => a 1-acyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67555", "l": "3'-phosphoadenylyl sulfate + cholate <=> adenosine 3',5'-bisphosphate + cholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70900", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate => (2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680811", "l": "nsp12 binds nsp7 and nsp8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.54", "l": "\"calpain-3\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49848", "l": "(-)-dehydrodiconiferyl acid ketone + a quinone + H2O = (-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.49", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14148", "l": "ATP + guanidinoacetate <=> ADP + H(+) + phosphoguanidinoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47554", "l": "deoxycholate + glycine => glycodeoxycholate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52969", "l": "hyocholate + UDP-alpha-D-glucuronate => H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684275", "l": "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863494", "l": "ASICs bind STOML3, (STOM) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654399", "l": "Activated FGFR2 binds FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39935", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71951", "l": "3 Na(+)(out) + sulfate(out) = 3 Na(+)(in) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47884", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250486", "l": "Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031844", "l": "type 4 neuropeptide Y receptor binding", "d": ["Binding to a type 4 neuropeptide Y receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382553", "l": "ABCA7:Apo1A-mediated phospholipid efflux (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68403", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-gurjunene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37307", "l": "glycyl-L-asparagine + H2O = glycine + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180728", "l": "Association of Ran-GTP with importin-beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437936", "l": "p-Y348-SYK phosphorylates VAV family (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67669", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199404", "l": "CD40L binds CD40 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61670", "l": "2-hydroxybenzoyl-CoA + AMP + diphosphate => ATP + CoA + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033230", "l": "ABC-type cysteine transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(out/in) = ADP + phosphate + cysteine(in/out)."]}, {"i": "RHEA:32795", "l": "ATP + H2O + L-cysteine(out) = ADP + H(+) + L-cysteine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56940", "l": "S-methyl-5-thio-D-ribulose 1-phosphate = 2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34769", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+) => 5,10-methenyltetrahydrofolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045430", "l": "chalcone isomerase activity", "d": ["Catalysis of the reaction: a chalcone = a flavanone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26328", "l": "(8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine <=> (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033462", "l": "GGC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GGC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57045", "l": "D-apionate + NAD(+) => 3-oxoisoapionate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71825", "l": "3,3'-diiodo-L-thyronine(in) => 3,3'-diiodo-L-thyronine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58777", "l": "NADP(+) + pyridine 3-methanol => H(+) + NADPH + pyridine-3-carbaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033803", "l": "kaempferol 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + H+ + kaempferide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22139", "l": "7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 <=> chlorophyllide b + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8856945", "l": "PP2A methylation by LCMT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665767", "l": "Activated FMNL3 binds G-actin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39484", "l": "3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20392", "l": "(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 <=> (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50055", "l": "ATP + H2O + taurocholate(in) <=> ADP + H(+) + phosphate + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53218", "l": "16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15319", "l": "2-deoxy-D-glucose + an alcohol => a 2-deoxy-alpha-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23563", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate <=> adenosylcob(III)alamin 5'-phosphate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70749", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17153", "l": "CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O", "d": []}, {"i": "EC:4.2.1.45", "l": "\"CDP-glucose 4,6-dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140221", "l": "Transactivation of BBC3 (PUMA) by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35261", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73393", "l": "H(+)(out) + phosphate(out) + sulfate(in) => H(+)(in) + phosphate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029456", "l": "RAC1 and CDC42 activate PAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37535", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0016749", "l": "N-succinyltransferase activity", "d": ["Catalysis of the transfer of a succinyl group to a nitrogen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30151", "l": "FADH2 + NADP(+) = FAD + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71941", "l": "2-oxoglutarate(in) + 3 Na(+)(in) => 2-oxoglutarate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0030291", "l": "protein serine/threonine kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15136", "l": "H2O + L-glutamate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72129", "l": "agmatine(out) + H(+)(in) => agmatine(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62802", "l": "2 H2O + NADP(+) + orlandin => 2 7-demethylsiderin + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26490", "l": "a secondary nitroalkane + H2O + O2 = a ketone + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042086", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to an acceptor molecule, dependent on the presence of 5-methyl-5,6,7,8-tetrahydromethanopterin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417843", "l": "P2Y13 binds ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74945", "l": "a (3R)-3-isocyanyl-fatty acid + 2 CO2 + 2 H2O + succinate => 2-oxoglutarate + a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043782", "l": "cobalt-precorrin-3 C17-methyltransferase activity", "d": ["Catalysis of the reaction: cobalt-precorrin 3 + S-adenosyl-L-methionine = cobalt-precorrin 4 + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20686", "l": "galactitol + NAD(+) => H(+) + keto-D-tagatose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983285", "l": "RAD51B binds RAD51C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45444", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629918", "l": "NEIL1 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59086", "l": "2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+) => 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682967", "l": "WHSC1 binds DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48064", "l": "ganglioside GD1b (d18:1(4E)) + H2O = ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2471621", "l": "Endostatin degradation by cathepsins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080044", "l": "quercetin 7-O-glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group from UDP-glucose to the 7-hydroxy group of a quercetin molecule."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051269", "l": "alpha-keto ester reductase activity", "d": ["Catalysis of the reaction: alpha-keto ester + 2 H+ (from donor) = (R)-hydroxy ester. Alpha-keto esters are of the form R(1)-CO-CO-O-R(2), where the R groups may be aromatic or aliphatic."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710254", "l": "GSDME oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33285", "l": "6-oxohexanoate + H2O + NADP(+) => 2-hydroxycyclohexan-1-one + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102115", "l": "peptidoglycan asparagine synthase activity", "d": ["Catalysis of the reaction: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparatyl)-L-lysyl-D-alanyl-D-alanine + ammonium + ATP = H+ + ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparaginyl)-L-lysyl-D-alanyl-D-alanine + AMP + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12140", "l": "a 2'-deoxyribonucleoside + ATP = a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12376", "l": "ATP + L-fuculose = ADP + H(+) + L-fuculose 1-phosphate", "d": []}, {"i": "EC:2.7.1.51", "l": "\"L-fuculokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.27", "l": "\"RING-type E3 ubiquitin transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70263", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047473", "l": "D-alanine [D-alanyl carrier protein] ligase activity", "d": ["Catalysis of the ATP-dependent activation of D-alanine and its transfer as a thiol ester to the phosphopantheinyl prosthetic group of a D-alanyl carrier protein, according to the reaction: ATP + D-alanine + a [D-alaninyl carrier protein] = a D-alanyl-[D-alanyl carrier protein] + AMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35604", "l": "beta-D-fructose 1-phosphate + H2O => D-fructose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25746", "l": "H(+) + N,N-dihydroxy-L-pentahomomethionine <=> (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37088", "l": "[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine => 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44684", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56250", "l": "2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein] => 1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706323", "l": "Active FLT3 binds to SLA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28219", "l": "chloride + H(+) + H2O2 => H2O + hypochlorous acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66226", "l": "asc-DeltaC9-CoA + H2O2 => asc-C9-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63338", "l": "beta-D-xylose => alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18073", "l": "(S)-dihydroorotate + A = AH2 + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187697", "l": "TRKA recruits RIT and RIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76018", "l": "(3R)-hydroxybutanoate trimer + H2O <=> (3R)-hydroxybutanoate dimer + (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55316", "l": "3 H2O + hydrogen sulfide + 3 NAD(+) = 4 H(+) + 3 NADH + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74444", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22010", "l": "CoA + O-succinyl-L-homoserine => L-homoserine + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43000", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate", "d": []}, {"i": "EC:4.2.3.151", "l": "\"pentamethylcyclopentadecatrienol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51648", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10941", "l": "(2E)-geranyl diphosphate => (4R)-limonene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19439", "l": "N-(beta-D-glucosyl)nicotinate + UDP => nicotinate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950173", "l": "Expression of ADP-ribosylation factor 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12510", "l": "loganin + S-adenosyl-L-homocysteine => loganate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14510", "l": "2-oxoglutarate + mugineate + O2 => 3-epihydroxymugineate + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14908", "l": "5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate <=> 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029680", "l": "Caspase-7 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810843", "l": "Envoplakin binds periplakin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50002", "l": "butan-1-ol + H2O + NAD(+) => butane + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0000978", "l": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "d": ["Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14186", "l": "3-phenylpyruvate + H(+) => 2-phenylacetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11993", "l": "L-pipecolate + O2 => H(+) + H2O2 + L-1-piperideine-6-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.152", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70916", "l": "guanosine(in) + H(+)(in) => guanosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41743", "l": "adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68123", "l": "a 1,2-diacylglycerol + a fatty acyl-CoA <=> a triacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34595", "l": "H(+) + isopentadecanoyl-CoA + L-serine = 3-dehydro-15-methylhexadecasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39212", "l": "(3R)-hydroxyhexacosanoyl-CoA => (2E)-hexacosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69792", "l": "D-phenylalanyl-tRNA(Phe) + H2O => D-phenylalanine + H(+) + tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74375", "l": "H2O2(out) = H2O2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21908", "l": "NADP(+) + scytalone = H(+) + NADPH + naphthalene-1,3,6,8-tetrol", "d": []}, {"i": "EC:1.1.1.252", "l": "\"tetrahydroxynaphthalene reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761822", "l": "NFE2L2 binds the IDH1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796626", "l": "MIB2 ubiquitinates CFLAR  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905058", "l": "calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "d": ["Any calcium-induced calcium release activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62072", "l": "D-galactose 6-phosphate + NADP(+) = 6-phospho-D-galactono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72285", "l": "a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0034584", "l": "piRNA binding", "d": ["Binding to a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72019", "l": "2-oxoglutarate + H(+) + O2 + trihazone A = 2 CO2 + H2O + succinate + trihazone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34762", "l": "ATP + glycerol 2-phosphate(out) + H2O <=> ADP + glycerol 2-phosphate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008814", "l": "citrate CoA-transferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18313", "l": "(R)-mandelonitrile = benzaldehyde + hydrogen cyanide", "d": []}, {"i": "EC:4.1.2.10", "l": "\"(R)-mandelonitrile lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20883", "l": "10-hydroxydecanoate + NAD(+) <=> 10-oxodecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20020", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 <=> 5,10-methylenetetrahydromethanopterin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33913", "l": "an alkylamine + glyoxylate + H2O2 => an N-alkylglycine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73594", "l": "CTP(out) + dUTP(in) <=> CTP(in) + dUTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40088", "l": "22-hydroxydocosanoate + NAD(+) => 22-oxodocosanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24213", "l": "5-(2-hydroxyethyl)-4-methylthiazole + ATP => 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48697", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O => H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31547", "l": "2 (2E,6E)-farnesyl diphosphate = 15-cis-4,4'-diapophytoene + 2 diphosphate", "d": []}, {"i": "EC:2.5.1.96", "l": "\"4,4'-diapophytoene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693783", "l": "NAALADases hydrolyse NAAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36268", "l": "caffeine + H(+) + NADH + O2 => formaldehyde + H2O + NAD(+) + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422454", "l": "Polysialylation of NCAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44830", "l": "CoA + O-decanoyl-(R)-carnitine => (R)-carnitine + decanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681169", "l": "CRBN binds IMiDs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432909", "l": "Interaction of Plectin with Integrin beta 4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031896", "l": "PD1n-3, PD2n-3 translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374669", "l": "L1 binds NRP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72483", "l": "(S)-malate(in) + citrate(out) = (S)-malate(out) + citrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20487", "l": "(S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63912", "l": "6-azauridine + ATP = 6-azauridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165179", "l": "Formation of TSC1:TSC2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388809", "l": "CTLA-4 binds B7-1/B7-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51333", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => 11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73685", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39294", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690461", "l": "FKBP1A binds tacrolimus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.112", "l": "\"adenylate dimethylallyltransferase (ADP/ATP-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60952", "l": "(E)-5-hydroxyferulate + S-adenosyl-L-methionine = (E)-sinapate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30537", "l": "biotin + H2O + NADP(+) => biotinate sulfoxide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007926", "l": "ATRX binds DAXX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35555", "l": "cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid", "d": []}, {"i": "EC:1.14.15.13", "l": "\"pulcherriminic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14985", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}, {"i": "EC:1.13.11.40", "l": "\"arachidonate 8-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31695", "l": "(9Z,12Z)-octadecadienoate + O2 = (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": []}, {"i": "EC:1.13.11.62", "l": "\"linoleate 10R-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37574", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748996", "l": "GST dimers cleave AZA to 6MP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214845", "l": "CACT and DL dimer are phosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28508", "l": "4-O-phospho-alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+) => alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445072", "l": "Interaction of PAK1 with Rac1-GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030787", "l": "inositol 4-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-4-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-921155", "l": "p-STAT5 dissociates from the receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650722", "l": "Translation of DDIT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45771", "l": "gamma-L-glutamyl-L-alaninol + H2O <=> L-alaninol + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63834", "l": "capsaicin + CoA + H(+) => (6E)-8-methylnon-6-enoyl-CoA + vanillylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694428", "l": "LMAN family proteins bind glycosylated cargo (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11603", "l": "ATP + CMP <=> ADP + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798749", "l": "Exocytosis of specific granule lumen proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30169", "l": "D-sedoheptulose 1,7-bisphosphate => D-erythrose 4-phosphate + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878023", "l": "SMAD6 gene expression is stimulated by RUNX2 and SMAD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139899", "l": "Sequestration of BAD protein by 14-3-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681840", "l": "RTC synthesizes SARS-CoV-1 plus strand genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168923", "l": "Collagen type XVIII endostatin release (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878654", "l": "ACP6 hydrolyses MYS-LPA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034899", "l": "trimethylamine monooxygenase activity", "d": ["Catalysis of the reaction: N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374686", "l": "L1 interaction with Integrins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23865", "l": "4-CDP-2-C-methyl-D-erythritol 2-phosphate => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989759", "l": "Expression of G0S2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.42", "l": "\"atrolysin C\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74774", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine <=> 3,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004648", "l": "O-phospho-L-serine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3159259", "l": "MMAA:MUT binds AdoCbl (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52157", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28657", "l": "glutathione + H(+) + sulfite => glutathione S,S-dioxide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51295", "l": "a quinone + H2O + L-methionyl-[protein] <=> a quinol + L-methionyl-(S)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2129357", "l": "Fibrillin C-terminal processing (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177926", "l": "Dephosphorylation of PAG by SHP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73087", "l": "AMP(out) + FAD(in) = AMP(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60748", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone = CoA + pyrethrin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801195", "l": "STEAP3 binds BNIP3L (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112037", "l": "Inactivation of PLC beta (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52858", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10289", "l": "H2O + L-rhamnono-1,4-lactone => H(+) + L-rhamnonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75242", "l": "acetyl-CoA + N-terminal L-methionyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686587", "l": "ABL1 phosphorylates RAD52 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.41", "l": "\"complement subcomponent C1r\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28122", "l": "ATP + di-trans,octa-cis-undecaprenol = ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53401", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47873", "l": "ganglioside GM1 + H2O => ganglioside GA1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858475", "l": "TNFSF9 binds TNFRSF9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13256", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28052", "l": "NAD(+) + phosphate => H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700171", "l": "Active ALK phosphorylates PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000170", "l": "sphingosine hydroxylase activity", "d": ["Catalysis of the hydroxylation of sphingolipid long chain bases."]}, {"i": "REACT:R-HSA-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112514", "l": "JAK activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48247", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 <=> CMP + ganglioside GM1b + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31969", "l": "ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673757", "l": "Ligand-independent dimerization of cytosolic PDGFRA and PDGFRB fusion proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71481", "l": "L-tyrosyl-L-isoleucyl-L-leucine + neurotensin(1-10) => H2O + neurotensin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54441", "l": "a (4S)-2,3-dehydroflavan-3,4-diol + H(+) => a 4-H-anthocyanidin with a 3-hydroxy group + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678327", "l": "MIOX oxidises Ins to GlcA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9612509", "l": "SGK phosphorylates SRF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047475", "l": "phenylacetate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + CoA + phenylacetate = AMP + diphosphate + H+ + phenylacetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-984606", "l": "Kinesin-5 is a homotetramer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64314", "l": "dihydrogeodin + 2 FAD + H(+) + 4 H2O => 2 chloride + 2 FADH2 + 2 O2 + sulochrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690494", "l": "RHOB translocates to the endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53526", "l": "1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0016262", "l": "protein N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42005", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446372", "l": "Association of  PARVA with TESK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56872", "l": "(S)-N-acetyl-1-phenylethylamine + H2O = (S)-1-phenylethylamine + acetate", "d": []}, {"i": "EC:3.5.1.85", "l": "\"(S)-N-acetyl-1-phenylethylamine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45896", "l": "an N-acyl-sphingoid base + CDP-ethanolamine = an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754554", "l": "SARS-COV 7a translocates to the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41692", "l": "1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33944", "l": "H(+) + 2 L-arginine + 3 NADH + 4 O2 => 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001065", "l": "mannan binding", "d": ["Binding to mannan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156678", "l": "Activation of Cdc25C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44049", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41158", "l": "1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-(8E)-octadecenoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13490", "l": "(S)-canadine + H(+) + 2 O2 => berberine + 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21314", "l": "CO2 + hydroquinone => 2,5-dihydroxybenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21731", "l": "GDP-alpha-D-mannose + H2O + 2 NAD(+) <=> GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66567", "l": "histamine + L-glutaminyl-[protein] <=> 5-histaminyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3244643", "l": "STING binds cyclic GMP-AMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23520", "l": "acetyl-CoA + propanoate = acetate + propanoyl-CoA", "d": []}, {"i": "EC:2.8.3.1", "l": "\"propionate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193703", "l": "IKKbeta is activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9726875", "l": "HCNs:cAMP bind SNIs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928617", "l": "EPHB2 binds KALRN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445699", "l": "ATP Hydrolysis By Myosin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27479", "l": "CO2 + formaldehyde + neopinone + succinate => 2-oxoglutarate + O2 + thebaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45070", "l": "CoA + O-acyl-(R)-carnitine => (R)-carnitine + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050612", "l": "arsenate reductase (donor) activity", "d": ["Catalysis of the reaction: A + arsenite + H2O = AH(2) + arsenate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045300", "l": "acyl-[acyl-carrier-protein] desaturase activity", "d": ["Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008517", "l": "folic acid transmembrane transporter activity", "d": ["Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.29", "l": "\"sphingolipid 8-(E/Z)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48037", "l": "globoside Gb4Cer (d18:1(4E)) + H2O => globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11220", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21702", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52180", "l": "(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64601", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050585", "l": "4-hydroxymandelate synthase activity", "d": ["Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13821", "l": "2-oxoglutarate + glutarate + O2 = (S)-2-hydroxyglutarate + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.64", "l": "\"glutarate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10518", "l": "(1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH => (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34236", "l": "4-nitro-6-oxohepta-2,4-dienedioate => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59719", "l": "D-maltopentaono-1,5-lactone + H2O <=> D-maltopentaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51894", "l": "acetate + cadaverine => H2O + N-acetylcadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24174", "l": "a 3-oxo-Delta(4)-steroid + AH2 => A + a 3-oxo-5beta-steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603419", "l": "Activated NTRK3 binds SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850797", "l": "SPINK6 binds KLK13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205289", "l": "Autophosphorylation of KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20033", "l": "isopenicillin N = penicillin N", "d": []}, {"i": "EC:5.1.1.17", "l": "\"isopenicillin-N epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45763", "l": "dTDP-beta-L-daunosamine + epsilon-rhodomycinone <=> dTDP + H(+) + rhodomycin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4647593", "l": "EP400 binds CDKN1A promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.1", "l": "\"dihydrouracil dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0035064", "l": "methylated histone binding", "d": ["Binding to a histone in which a residue has been modified by methylation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19718", "l": "H(+) + L-phenylalanine => 2-phenylethylamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35949", "l": "chanoclavine-I aldehyde + H(+) + NADPH => dihydrochanoclavine-I aldehyde + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58335", "l": "(E)-non-2-en-1-ol + NADP(+) <=> (E)-non-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42080", "l": "all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38715", "l": "ATP + choline(out) + H2O = ADP + choline(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690196", "l": "USP8 deubiquitinates RNF128 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10284", "l": "L-leucine = (3R)-beta-leucine", "d": []}, {"i": "EC:5.4.3.7", "l": "\"leucine 2,3-aminomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021050", "l": "HSBP1 oligomer binds ESRs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43749", "l": "ATP + CoA + hexacosanoate => AMP + diphosphate + hexacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.2", "l": "\"pectate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52178", "l": "14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50804", "l": "glutathione + prostaglandin J2 = prostaglandin J2-S-(R)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31803", "l": "H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose = 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP", "d": []}, {"i": "EC:3.6.1.57", "l": "\"UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140630", "l": "all-trans-phytoene synthase activity", "d": ["Catalysis of the reaction: 2 geranylgeranyl diphosphate -> all-trans-phytoene + 2 diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25495", "l": "(2E)-geranyl diphosphate <=> (-)-beta-phellandrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110363", "l": "FEN1 bound to PCNA and APEX1 cleaves flap ssDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28511", "l": "arbutin 6-phosphate + H2O => beta-D-glucose 6-phosphate + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674531", "l": "AAMP binds EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48915", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a <=> CMP + ganglioside GT1a + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70497", "l": "D-glucose(in) + 2 Na(+)(in) => D-glucose(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42641", "l": "a 2-demethylmenaquinol + S-adenosyl-L-methionine => a menaquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814094", "l": "ARL1:GTP binds ARFIP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005502", "l": "11-cis retinal binding", "d": ["Binding to 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623643", "l": "RDH13 reduces atRAL to atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.2.-", "l": "\"Hydron translocation linked to the hydrolysis of a nucleoside triphosphate\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22669", "l": "2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H(+) + lipid A disaccharide (E. coli) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26388", "l": "all-trans-8'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50300", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454916", "l": "The ABCC family mediates organic anion transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388605", "l": "POMC(138-176) binds MC2R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37710", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652816", "l": "Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395801", "l": "Phosphorylation of LAT by p-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31165", "l": "(2E)-hexadecenoyl-CoA + H2O => (3S)-hydroxyhexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63122", "l": "(11Z)-eicosenoate + NH4(+) => (11Z)-eicosenamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28824", "l": "H(+)(in) + L-galactonate(in) => H(+)(out) + L-galactonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23803", "l": "H2O + L-methionine <=> 2-oxobutanoate + methanethiol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40345", "l": "acetyl-CoA + tetradecanedioyl-CoA => 3-oxohexadecanedioyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034003", "l": "vetispiradiene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + vetispiradiene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19812", "l": "(S)-ureidoglycolate + 2 H(+) + H2O <=> CO2 + glyoxylate + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30353", "l": "5-hydroxypyrrole-2-carboxylate + H2O + NAD(+) => H(+) + NADH + O2 + pyrrole-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070401", "l": "NADP+ binding", "d": ["Binding to the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39274", "l": "(3R)-hydroxy-(15Z)-tetracosenoyl-CoA <=> (2E,15Z)-tetracosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.35", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53013", "l": "2,5-dichlorohydroquinone + 2 glutathione => chloride + chlorohydroquinone + glutathione disulfide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75178", "l": "dATP + NAD(+) <=> dADP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669023", "l": "TWEAK binds FN14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373716", "l": "DCC interacting NCK-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.39", "l": "\"gluconate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5220959", "l": "TDG excises 5-formylcytosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11839", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine <=> CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26264", "l": "H2O + isopimara-7,15-dienal + NADP(+) <=> 2 H(+) + isopimarate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28941", "l": "H(+)(out) + xanthosine(out) => H(+)(in) + xanthosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690740", "l": "CD22 binds B-cell receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "53.254519724904085", "identifiers": [{"i": "GO:0022834", "l": "ligand-gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58553", "l": "15alpha-stemmadenine intermediate II + H2O => (16R)-deshydroxymethyl-stemmadenine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36392", "l": "cholesterol + NADP(+) => desmosterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13962", "l": "ATP + H2O + Mg(2+) + protoporphyrin IX => ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103035", "l": "NAD(P)H:methyl-1,4-benzoquinone oxidoreductase activity", "d": ["Catalysis of the reaction: 3 H+ + methyl-1,4-benzoquinone + NADPH = methyl-1,4-benzoquinol + NADP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004797", "l": "thymidine kinase activity", "d": ["Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50948", "l": "a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O = a 2'-deoxyuridine in single-stranded DNA + NH4(+)", "d": []}, {"i": "EC:3.5.4.38", "l": "\"single-stranded DNA cytosine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015395", "l": "nucleoside transmembrane transporter activity, down a concentration gradient", "d": ["Enables the transfer of a nucleoside, from one side of a membrane to the other, down the concentration gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25483", "l": "acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71602", "l": "2-oxoglutarate(out) + maleate(in) <=> 2-oxoglutarate(in) + maleate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.173", "l": "\"L-rhamnose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43626", "l": "aminoacetaldehyde + CO2 => 2-aminomalonate semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43780", "l": "2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49190", "l": "a 3-vinylbacteriochlorophyllide d + H2O => a bacteriochlorophyllide d", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73553", "l": "GDP(in) + UTP(out) => GDP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851890", "l": "MET phosphorylates SHC1-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047503", "l": "(-)-borneol dehydrogenase activity", "d": ["Catalysis of the reaction: (-)-borneol + NAD+ = (1S,4S)-camphor + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39184", "l": "3-oxodocosanoyl-CoA + H(+) + NADPH => (3R)-hydroxydocosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57723", "l": "ATP + 4 H(+)(in) + H2O <=> ADP + 5 H(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061891", "l": "calcium ion sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of calcium ions (Ca2+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093329", "l": "EFNBs bind SDCBP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69053", "l": "RFC binding displaces Pol Alpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42133", "l": "isonocardicin C => nocardicin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010951", "l": "ROBO1 binds NRP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2197698", "l": "Src phosphorylate WASP,N-WASP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168947", "l": "Ligand binds to TLR10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36437", "l": "a 1,2-diacyl-sn-glycero-3-phosphate(out) => a 1,2-diacyl-sn-glycero-3-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10924", "l": "cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide", "d": []}, {"i": "EC:5.2.1.10", "l": "\"2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950398", "l": "CANX dissociates from IL27:EBI3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74533", "l": "2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaetidylglycerol => AH2 + archaetidylglycerol + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42741", "l": "guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50474", "l": "(2-aminobenzoyl)acetyl-CoA + CO2 + CoA => anthraniloyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799409", "l": "HIPK2 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61033", "l": "3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine => 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12423", "l": "ATP + D-tagatofuranose 6-phosphate <=> ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75244", "l": "FASL binds FAS Receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37280", "l": "ATP + H2O + L-alanyl-L-histidine(out) => ADP + H(+) + L-alanyl-L-histidine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53259", "l": "lathosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75845", "l": "ergothioneine(in) + Na(+)(in) => ergothioneine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29058", "l": "a ubiquinone + 2 H(+)(in) + H2 <=> a ubiquinol + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22089", "l": "ATP + GTP => AMP + guanosine 3'-diphosphate 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56394", "l": "(3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+) => [(3R)-hydroxybutanoate](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36056", "l": "a 2-amino-4-hydroxypteridine + H(+) + H2O => a 2,4-dihydroxypteridine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031866", "l": "EP3 subtype prostaglandin E2 receptor binding", "d": ["Binding to an EP3 subtype prostaglandin E2 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26475", "l": "beta-D-galactosyl-(1->4)-L-rhamnose + phosphate => alpha-D-galactose 1-phosphate + L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69147", "l": "agmatine + H2O + O2 <=> 4-guanidinobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28132", "l": "baicalein + D-glucuronate + H(+) => baicalin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33447", "l": "4beta-methylzymosterol-4alpha-carboxylate + NADP(+) = 3-dehydro-4-methylzymosterol + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029456", "l": "RAC1 and CDC42 activate PAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61806", "l": "diphosphate + L-alanyl-5'-AMP => ATP + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17570", "l": "(R)-reticuline + NADP(+) => 1,2-dehydroreticuline + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35017", "l": "riboflavin(out) => riboflavin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51886", "l": "D-proline betaine => L-proline betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9633044", "l": "ESR binds STRN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4608855", "l": "PRICKLE1 is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168459", "l": "Lyn activates ERK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59603", "l": "5-methoxytryptamine + H2O + O2 <=> 5-methoxyindoleacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.23", "l": "\"rhamnogalacturonan endolyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0033694", "l": "oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein."]}, {"i": "EC:1.5.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55296", "l": "13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-500717", "l": "Activation of GRIK3 homomer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75291", "l": "glyoxylate(in) + oxalate(out) = glyoxylate(out) + oxalate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30389", "l": "alpha-D-glucose 1-phosphate + GDP + H(+) => GDP-alpha-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173631", "l": "Activation of C1s (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047468", "l": "phosphoglucomutase (glucose-cofactor) activity", "d": ["Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate; using D-glucose as a cofactor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63435", "l": "1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57188", "l": "H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] = glycolate + H(+) + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:1903425", "l": "fluoride transmembrane transporter activity", "d": ["Enables the transfer of fluoride from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.-.-", "l": "\"Glycosylases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419428", "l": "S1PR2-5 bind S1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11297", "l": "2,5-dioxopentanoate + H2O + NADP(+) => 2-oxoglutarate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30761", "l": "NH4(+) + thymine => 5-methylcytosine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173725", "l": "C9 binds C5b:C6:C7:C8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74854", "l": "acetaldehyde + dopamine <=> (R)-salsolinol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29460", "l": "beta-alanine(in) + H(+)(in) => beta-alanine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700156", "l": "Active ALK dimer binds IRS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167196", "l": "Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52802", "l": "AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid => acetoacetyl-CoA + ATP + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23267", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+) <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74692", "l": "2 a 2,3-di-O-phytanyl-sn-glycerophospholipid + 2 AH2 + 4 S-adenosyl-L-methionine => 4 5'-deoxyadenosine + 2 A + a glycerol dibiphytanyl glycerol tetraether phospholipid + 4 H(+) + 4 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36111", "l": "gibberellin A1 + S-adenosyl-L-methionine = O-methyl gibberellin A1 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70727", "l": "3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O = 6-sulfo-alpha-D-quinovose + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47495", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isodeoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111238", "l": "Formation of ADAR2  homodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3132759", "l": "TCN1 binds RCbl (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004775", "l": "succinate-CoA ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47821", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64559", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one <=> 8-epi-ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59512", "l": "acetylsalicylate + L-seryl-[protein] = O-acetyl-L-seryl-[protein] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55017", "l": "H(+) + menthone + NADPH + O2 => 7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58912", "l": "ATP + H2O + iron(III) dicitrate(out) = ADP + H(+) + iron(III) dicitrate(in) + phosphate", "d": []}, {"i": "EC:7.2.2.18", "l": "\"ABC-type ferric citrate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008816", "l": "citryl-CoA lyase activity", "d": ["Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14773", "l": "2 NADPH + palmatine + S-adenosyl-L-methionine = corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.147", "l": "\"corydaline synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449117", "l": "TXLNA (IL14) binds syntaxin1A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372388", "l": "fructose 1,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29331", "l": "fumarate(in) + 2 H(+)(in) = fumarate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928625", "l": "PAKs autophosphorylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6795290", "l": "TORC2 complex phosphorylates SGK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169210", "l": "PTP1B dephosphorylates JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68598", "l": "beta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807872", "l": "Active ARF recruits coatomer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9609310", "l": "β-blockers bind ADRB1,2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26189", "l": "1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67352", "l": "malonyl-CoA + rhaponticin = 6-O-malonyl-rhaponticin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75701", "l": "glutathione disulfide + H(+) + NADH => 2 glutathione + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805730", "l": "SETD9 methylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878130", "l": "CDKN1A (p21) gene expression is positively regulated by RUNX3 and ZFHX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939335", "l": "RNF181 polyubiquinates BCL10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047778", "l": "[citrate-(pro-3S)-lyase] thiolesterase activity", "d": ["Catalysis of the reaction: [citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57980", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose = (20S)-ginsenoside F1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168960", "l": "Collagen type XVII ectodomain shedding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65133", "l": "2-oxoglutarate + O2 + preaustinoid A1 => CO2 + H2O + preaustinoid A2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.213", "l": "\"galactan exo-1,6-beta-galactobiohydrolase (non-reducing end)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1449597", "l": "p-AKT2 phosphorylates Myosin 5A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21288", "l": "D-glucose + sn-glycerol 3-phosphate = D-glucose 6-phosphate + glycerol", "d": []}, {"i": "EC:2.7.1.142", "l": "\"glycerol-3-phosphate--glucose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57053", "l": "3-oxoisoapionate + H(+) => CO2 + L-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796300", "l": "Expression of NOTO in axial mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33520", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphinganine => (4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34594", "l": "Co-precorrin-7 + S-adenosyl-L-methionine <=> Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1297333", "l": "Association of Acrosin Heavy and Light Chain (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811412", "l": "Active ARF recruits coatomer to the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34927", "l": "H(+) + NADPH + selenodiglutathione = glutathione + glutathioselenol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36265", "l": "acetate + H(+) + O-ureido-L-serine => hydroxyurea + O-acetyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0140272", "l": "exogenous protein binding", "d": ["Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694681", "l": "mRNA5 is translated to protein M (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43184", "l": "S-adenosyl-L-methionine + uridine(2843) in 25S rRNA = H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.312", "l": "\"25S rRNA (uracil(2843)-N(3))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871227", "l": "RET binds GFRA4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0000213", "l": "tRNA-intron endonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72588", "l": "(E)-sinapate + ATP + CoA => (E)-sinapoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52759", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34244", "l": "GTP + H(+) + Mo-molybdopterin => diphosphate + Mo-molybdopterin guanine dinucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17791", "l": "(S)-reticuline + H(+) + S-adenosyl-L-homocysteine => (S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106073", "l": "dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity", "d": ["Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33501", "l": "3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2 => H(+) + prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29811", "l": "ATP + H2O + thiamine(out) = ADP + H(+) + phosphate + thiamine(in)", "d": []}, {"i": "EC:7.6.2.15", "l": "\"ABC-type thiamine transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4570528", "l": "SUMOylation of XPC with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62806", "l": "desertorin A + 2 H2O + NADP(+) => 2 7-demethylsiderin + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50701", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39527", "l": "(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH = (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102937", "l": "16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 16-alpha-hydroxygypsogenate = 16-alpha-hydroxygypsogenate-28-beta-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62644", "l": "(5Z,8Z)-eicosadienoate + O2 = (5S)-hydroperoxy-(6E,8Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66106", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018808", "l": "RAC3 binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46677", "l": "(4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+) => (6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30600", "l": "15-cis-phytoene + 3 A => 3 AH2 + all-trans-neurosporene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112703", "l": "PTPN11 is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51005", "l": "a primary alcohol + 2 Fe(III)-[cytochrome cL] => an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21584", "l": "NAD(+) + propane-1,2-diol 1-phosphate = H(+) + hydroxyacetone phosphate + NADH", "d": []}, {"i": "EC:1.1.1.7", "l": "\"propanediol-phosphate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.6", "l": "\"pyroglutamyl-peptidase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35524", "l": "H(+) + N-ethylmaleimide + NADPH => N-ethylsuccinimide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65327", "l": "acetyl-CoA + chrodrimanin A <=> chrodrimanin B + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37423", "l": "aclacinomycin N + O2 = aclacinomycin A + H2O2", "d": []}, {"i": "EC:1.1.3.45", "l": "\"aclacinomycin-N oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73117", "l": "H(+) + rhamnetin + S-adenosyl-L-homocysteine => quercetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799761", "l": "TP53 binds PPP1R13L (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47342", "l": "6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58065", "l": "O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin => 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11266", "l": "H2O2 + NAD(+) => H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37572", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62700", "l": "H2O + naphtopyrone YWA1 = acetoacetate + H(+) + naphthalene-1,3,6,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421161", "l": "hypoxanthine + H2O + NAD+ => xanthine + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69709", "l": "beta-D-galactose + N-hexadecanoylsphinganine => beta-D-galactosyl-(1<->1')-N-hexadecanoylsphinganine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975594", "l": "PLB1 hydrolyses RPALM to atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59401", "l": "L-2-aminohexanoate => D-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047069", "l": "7,8-dihydroxykynurenate 8,8a-dioxygenase activity", "d": ["Catalysis of the reaction: 7,8-dihydroxykynurenate + O2 = 5-(3-carboxylato-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44097", "l": "decan-1-ol + hexadecanoyl-CoA => CoA + decanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13127", "l": "CoA-glutathione + glutathione => CoA + glutathione disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004969", "l": "histamine receptor activity", "d": ["Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047627", "l": "adenylylsulfatase activity", "d": ["Catalysis of the reaction: 5'-adenylyl sulfate + H2O = AMP + 2 H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382096", "l": "Formation of NR-NCOR Corepressor Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047016", "l": "cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295599", "l": "SPRY2 translocates to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16604", "l": "L-aspartate <=> fumarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.14", "l": "\"chlorophyllase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3321883", "l": "MSL acetylates histone H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55920", "l": "[cis-1,4-isoprene](n) + O2 = (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)", "d": []}, {"i": "EC:1.13.11.85", "l": "\"exo-cleaving rubber dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2203479", "l": "STAB2 (FEEL-2) binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48747", "l": "(-)-yatein + 2-oxoglutarate + O2 <=> (-)-deoxypodophyllotoxin + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824268", "l": "Expression of HES7 in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016509", "l": "long-chain-3-hydroxyacyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46190", "l": "a carboxylate + NH4(+) => an aliphatic nitrile + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26121", "l": "2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45420", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine = a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59667", "l": "D-cellopentaose + O2 <=> D-cellopentaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31965", "l": "9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32585", "l": "6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => dihydrocarvone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11796", "l": "ecdysone + O2 = 3-dehydroecdysone + H2O2", "d": []}, {"i": "EC:1.1.3.16", "l": "\"ecdysone oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25466", "l": "diphosphate + longifolene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40190", "l": "(2E)-octenoyl-CoA + H2O <=> (3R)-hydroxyoctanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17992", "l": "ATP + L-seryl-[protein] <=> ADP + H(+) + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12349", "l": "(S)-muconolactone => (4,5-dihydro-5-oxofuran-2-yl)-acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9621179", "l": "Cinaciguat binds sGC:NO (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625416", "l": "Anterograde IFT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52236", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 = 3 A + Fe(2+) + 3 H2O + mycobilin b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10742", "l": "a ketone + H(+) + NADH => a secondary alcohol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015098", "l": "molybdate ion transmembrane transporter activity", "d": ["Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54796", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) = an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.412", "l": "\"2-alkyl-3-oxoalkanoate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617471", "l": "HOXA1 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29163", "l": "2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out) = 2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59414", "l": "NH4(+) + oxaloacetate => 2-oxosuccinamate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380508", "l": "Translocation of NuMA to the centrosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64305", "l": "1-phenylpropylamine + pyruvate => 1-phenylpropan-1-one + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70489", "l": "a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696274", "l": "RND1 binds GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40419", "l": "H2O + phytanoyl-CoA = 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031172", "l": "ornithine N5-monooxygenase activity", "d": ["Catalysis of the reaction: L-ornithine + O2 + H+ = N5-hydroxy-L-ornithine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70251", "l": "beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0016859", "l": "cis-trans isomerase activity", "d": ["Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers."]}, {"i": "EC:5.2.-.-", "l": "\"Cis-trans-isomerases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18959", "l": "(1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-996755", "l": "ZFPM proteins bind GATA proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22082", "l": "H2O + NAD(+) + quinoline-2,8-diol => H(+) + NADH + O2 + quinolin-2-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672961", "l": "PP2A dephosphorylates inactive RAFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-573294", "l": "Activated TRAF6 synthesizes free K63 linked pUb chains. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684006", "l": "KPNA2 translocates NBN to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9681616", "l": "AP2 binds chlorpromazine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13613", "l": "beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate", "d": []}, {"i": "EC:2.7.1.90", "l": "\"diphosphate--fructose-6-phosphate 1-phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30249", "l": "O2 + 2 plastoquinol-9 => 2 H2O + 4 hnu + 2 plastoquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444100", "l": "PROT mediates L-proline uptake (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18865", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA = (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA", "d": []}, {"i": "EC:2.3.1.168", "l": "\"dihydrolipoyllysine-residue (2-methylpropanoyl)transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981621", "l": "Neuroglobin:oxygen dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18597", "l": "H(+) + NAD(+) + 2 reduced [rubredoxin] = NADH + 2 oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419049", "l": "ROCK activation by RHO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24739", "l": "(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.1", "l": "\"ABC-type polar-amino-acid transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203973", "l": "Vesicle budding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27276", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.12.1", "l": "\"5' to 3' exodeoxyribonuclease (nucleoside 3'-phosphate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428917", "l": "G13 activation by TP receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867613", "l": "PICALM binds R-SNAREs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0106006", "l": "cytoskeletal protein-membrane anchor activity", "d": ["The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a plasma membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific cortical membrane location."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399930", "l": "Activation of PAK by Rac1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60909", "l": "a cytidine in tRNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50499", "l": "acetyl-CoA + N-terminal glycyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68835", "l": "(2Z,6Z)-farnesyl diphosphate + H2O <=> (6Z)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45886", "l": "4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52574", "l": "(2E)-butenoyl-CoA + H(+) + NADH => butanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862733", "l": "CCR2, CCR3 bind CCL13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433506", "l": "Phosphorylation of APS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59976", "l": "2-phenylacetate + H(+) = CO2 + toluene", "d": []}, {"i": "EC:4.1.1.119", "l": "\"phenylacetate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50422", "l": "H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73695", "l": "dADP(out) + H(+)(out) + phosphate(in) = dADP(in) + H(+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45049", "l": "acetamide + H2O => acetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34838", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine <=> a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3788061", "l": "Fibronectin degradation by ADAM8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733316", "l": "p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102580", "l": "cyanidin 3-O-glucoside 2-O''-xylosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-xylose <=> cyanidin 3-O-beta-D-sambubioside + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047083", "l": "5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity", "d": ["Catalysis of the reaction: O2 + NADPH + H+ + trans-5-O-(4-coumaroyl)-D-quinate = H2O + NADP+ + trans-5-O-caffeoyl-D-quinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849085", "l": "ARHGAP35 binds RHOA:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57242", "l": "N(2)-(1-hydroxy-2-oxoethyl)-GMP => glyoxal + GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47370", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70659", "l": "H(+)(in) + N,N-dimethylglycine(in) = H(+)(out) + N,N-dimethylglycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25064", "l": "3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH => 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418845", "l": "Activation of caspase-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003938", "l": "IMP dehydrogenase activity", "d": ["Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13174", "l": "H2O + NAD(+) + phosphonate => H(+) + NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39266", "l": "(2E,13Z)-docosadienoyl-CoA + H(+) + NADPH <=> (13Z)-docosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11321", "l": "UDP-beta-L-arabinopyranose => UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19155", "l": "7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP => apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853921", "l": "VENTX stimulates p16-INK4A transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42246", "l": "3-oxopentanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52389", "l": "ATP + D-threonate => 4-O-phospho-D-threonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681616", "l": "AP2 binds chlorpromazine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202212", "l": "Recruitment of PLC-gamma1 to LAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51125", "l": "uridine in snRNA => pseudouridine in snRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63668", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41281", "l": "octadecanoate + sphing-4-enine => H2O + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0050263", "l": "ribosylpyrimidine nucleosidase activity", "d": ["Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16322", "l": "(S)-indan-1-ol + NADP(+) => H(+) + indan-1-one + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55850", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432164", "l": "Ca2+ influx into the post-synaptic cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034895", "l": "pyridine-3,4-diol dioxygenase activity", "d": ["Catalysis of the reaction: pryidine-3,4-diol + O2 = 3-(N-formyl)-formiminopyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201637", "l": "Caspase-mediated cleavage of plectin-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357445", "l": "PAK1-3 dimer disassociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14450", "l": "chlorophyllide a + NADP(+) => 3,8-divinyl chlorophyllide a + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13380", "l": "alpha-D-glucose 1-phosphate + ATP <=> ADP + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30387", "l": "GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48476", "l": "ganglioside GT1a (d18:1(4E)) + H2O = ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848713", "l": "PTK6 binds BCAR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052909", "l": "18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity", "d": ["Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17560", "l": "anthranilate + malonyl-CoA <=> CoA + N-malonylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668714", "l": "RAC1:GTP binds NOX1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49945", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate => (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.-", "l": "\"Acid--thiol ligases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31193", "l": "(2E)-decenoyl-CoA + H2O => (3S)-hydroxydecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202437", "l": "Phosphorylation of CARMA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54432", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 = a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58600", "l": "2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44485", "l": "3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614460", "l": "Dimerization of procollagen type VI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52214", "l": "ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] => acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32812", "l": "benzoate(in) => benzoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27280", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26422", "l": "3'-phosphoadenylyl sulfate + thyroxine = adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate", "d": []}, {"i": "EC:2.8.2.n2", "l": "\"thyroxine sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44085", "l": "ATP + CoA + heptadecanoate => AMP + diphosphate + heptadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661425", "l": "BIL:ALB dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5649856", "l": "Oxidative damage to the AP site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047887", "l": "farnesyl diphosphate kinase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + ATP = 2-trans,6-trans-farnesyl triphosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950778", "l": "p-Y693-STAT4 dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44926", "l": "(R)-dihomocitrate + CoA + H(+) => 2-oxoadipate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21779", "l": "(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA <=> (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67557", "l": "3'-phosphoadenylyl sulfate + glycocholate => adenosine 3',5'-bisphosphate + glycocholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62082", "l": "6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH => D-glucose 6-sulfate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26214", "l": "9alpha-copalyl diphosphate + H2O => aphidicolan-16beta-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186771", "l": "RNF111 binds SMAD7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62539", "l": "digoxigenin + 2 Fe(II)-[cytochrome c] + 3 H(+) <=> dihydrodigoxigenin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46025", "l": "H2O2 + tetradecanoate => (3R)-hydroxytetradecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46662", "l": "5beta-pregnan-3,20-dione + NADP(+) => H(+) + NADPH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71630", "l": "phosphate(in) + succinate(out) <=> phosphate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2426566", "l": "Interaction of DAP12 and CLM7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848250", "l": "ACBD6 binds LCFA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690785", "l": "BAP1 binds Ub-HCFC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41001", "l": "1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64937", "l": "dGTP + H2O => dGDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046972", "l": "histone H4K16 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46070", "l": "(2E)-nonenoyl-CoA => (3E)-nonenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112430", "l": "Formation of P-TEFb complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045509", "l": "interleukin-27 receptor activity", "d": ["Combining with interleukin-27 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29448", "l": "glycolate(in) => glycolate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15488", "l": "(2R,3S)-homoisocitrate <=> cis-homoaconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654625", "l": "Activated FGFR3 binds SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11348", "l": "arsenite(in) + ATP + H2O = ADP + arsenite(out) + H(+) + phosphate", "d": []}, {"i": "EC:7.3.2.7", "l": "\"arsenite-transporting ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018768", "l": "RHOU auto-activates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428752", "l": "Dissociation of the TP:Gq complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42771", "l": "a (2S)-2-hydroxycarboxylate + NADP(+) <=> a 2-oxocarboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57569", "l": "7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58157", "l": "ATP + H2O + 4 Na(+)(in) => ADP + H(+) + 4 Na(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11594", "l": "dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase] => dihydromonacolin L-[lovastatin nonaketide synthase] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140892", "l": "sodium,bicarbonate:chloride antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction chloride(in) + 2 hydrogencarbonate(out) + Na+(out) = chloride(out) + 2 hydrogencarbonate(in) + Na+(in)."]}, {"i": "TCDB:2.A.31.2.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676255", "l": "Formation of the MLL2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70596", "l": "GOT2 dimer deaminates L-Asp (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75675", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate = (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44108", "l": "H2O + heptanal + NAD(+) = 2 H(+) + heptanoate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0000175", "l": "3'-5'-RNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.11", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042123", "l": "glucanosyltransferase activity", "d": ["Catalysis of the splitting and linkage of glucan molecules, resulting in glucan chain elongation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63183", "l": "NADPH + 2 O2 <=> H(+) + NADP(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939929", "l": "ESRRA:PPARG1CA binds the RUNX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70007", "l": "anthranilate + ATP + H(+) = 2-aminobenzoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63268", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24138", "l": "a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+) => 3'-phosphoadenylyl sulfate + a primary amine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004045", "l": "aminoacyl-tRNA hydrolase activity", "d": ["Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18585", "l": "D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate", "d": []}, {"i": "EC:5.3.1.1", "l": "\"triose-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53460", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33463", "l": "episterol + H(+) + NADPH + O2 = 5-dehydroepisterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821931", "l": "BOD1L1 binds SET1A complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210285", "l": "Trans-homophilic interaction of PECAM-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047509", "l": "(R)-dehydropantoate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-4-dehydropantoate + H2O + NAD+ = (R)-3,3-dimethylmalate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37646", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392749", "l": "Transport of L1 into endosomes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19487", "l": "beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP => sphing-4-enine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-517705", "l": "p-S318,221-HuR binds mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37998", "l": "all-trans-nonaprenyl diphosphate + H(+) + homogentisate <=> 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218812", "l": "FYN phosphorylates PAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034787", "l": "1-hydro-1,1a-dihydroxy-9-fluorenone dehydrogenase activity", "d": ["Catalysis of the reaction: 1-hydro-1,1a-dihydroxy-9-fluorenone + H2O = 2,3-dihydroxy-2'-carboxybiphenyl + 3 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68615", "l": "Formation of ORC(1-6) complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371527", "l": "HSF1 trimer translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031521", "l": "NR1H2,3 binds the APOC2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5444511", "l": "Formation of MSH2:MSH3 Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20161", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose = myo-inositol + raffinose", "d": []}, {"i": "EC:2.4.1.82", "l": "\"galactinol--sucrose galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33035", "l": "2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044687", "l": "geranylfarnesyl diphosphate synthase activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49728", "l": "2 H(+) + NADPH + 2 O2 + protoviolaceinate = CO2 + 2 H2O + NADP(+) + violacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693608", "l": "Initial resection of double-strand break ends (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247511", "l": "STAB2:ligand is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62732", "l": "(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) = (+)-isomalbrancheamide D + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37260", "l": "(2S)-2-aminobutanoate + H2O + NAD(+) => 2-oxobutanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944236", "l": "Association of procollagen type XIV (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47574", "l": "CMP + ganglioside GT1b (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0051424", "l": "corticotropin-releasing hormone binding", "d": ["Binding to corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71303", "l": "RPE dimers isomerise RU5P to XY5P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57387", "l": "(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA <=> (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41848", "l": "(2E)-octenoyl-[ACP] + H(+) + NADPH = NADP(+) + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228408", "l": "Retrograde transport of internalized tetX HC:LC:gangliosides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65602", "l": "2 H(+) + jolkinol C + 2 NADH => 4,5,8-trihydroxycasbene + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170159", "l": "Translocation of Cdc25 to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22727", "l": "a sterol + UDP-alpha-D-glucose <=> a sterol 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11113", "l": "H2O + isochorismate => (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20876", "l": "(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.3", "l": "\"(R)-benzylsuccinyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49336", "l": "2,2-dihydroxyspheroidene = H2O + spheroiden-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421471", "l": "hydroxymethylbilane => uroporphyrinogen I + H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009282", "l": "CDK1 phosphorylates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853762", "l": "RET dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67866", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391372", "l": "GNRHR binds GNRH1,2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166041", "l": "Transfer of LPS onto TLR4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25739", "l": "N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38106", "l": "L-galactonate <=> 2-dehydro-3-deoxy-L-galactonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39908", "l": "2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose => dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68241", "l": "L-methionine(in) + Na(+)(in) => L-methionine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29975", "l": "2'-deoxycytidine(in) + H(+)(in) = 2'-deoxycytidine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69068", "l": "RFC dissociates after sliding clamp formation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102359", "l": "daphnetin 4-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 7,8-dihydroxycoumarin <=> UDP + 4-O- beta -D-glucosyl-daphnetin + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655142", "l": "RCHY1 binds POLH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66734", "l": "ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate => ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39960", "l": "1-hexadecanoylglycerol + H2O => glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390597", "l": "Release Of ADP From Myosin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43723", "l": "juvenile hormone III carboxylate + S-adenosyl-L-methionine <=> juvenile hormone III + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21992", "l": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44868", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol = 1,2-diacyl-sn-glycero-3-phosphoethanol + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964588", "l": "CCNA2 gene expression is inhibited by RBL1 and RBL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51306", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18534", "l": "5-hydroxy-L-tryptophan + H(+) => CO2 + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809309", "l": "MTMR6 binds MTMR9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.295", "l": "\"momilactone-A synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016155", "l": "formyltetrahydrofolate dehydrogenase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + H2O + NADP+ = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49351", "l": "2,2-dihydroxyspirilloxanthin <=> 2-oxospirilloxanthin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15738", "l": "cyclopentanone + H(+) + NADPH + O2 => 5-valerolactone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33636", "l": "ATP + CoA + docosanoate => AMP + diphosphate + docosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102734", "l": "brassinolide synthase activity", "d": ["Catalysis of the reaction: H+ + castasterone + NADPH + O2 <=> brassinolide + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.122", "l": "\"transmembrane protease serine 2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165680", "l": "Formation of active mTORC1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66610", "l": "GpCpCpA + H(+) + tRNA 3'-end (ribonucleotide 3'-phosphate) => (tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63881", "l": "2 Fe(III)-[cytochrome c] + H2O + thiocyanate => cyanate + 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42889", "l": "(R)-3-phosphomevalonate + ATP => (R)-3,5-bisphosphomevalonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70476", "l": "2 S-adenosyl-L-methionine + sphing-4-enine => 2 H(+) + N,N-dimethylsphing-4-enine + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050069", "l": "lysine dehydrogenase activity", "d": ["Catalysis of the reaction: L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3274540", "l": "Defective G6PC does not hydrolyze glucose 6-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047396", "l": "glycosylphosphatidylinositol diacylglycerol-lyase activity", "d": ["Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018758", "l": "RHOH binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67585", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:1990190", "l": "peptide-glutamate-alpha-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43190", "l": "H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2634) in 25S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0003973", "l": "(S)-2-hydroxy-acid oxidase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11048", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-organyl-2-lyso-sn-glycero-3-phospholipid = 1-O-alkyl-sn-glycero-3-phosphocholine + a 1-organyl-2-acetyl-sn-glycero-3-phospholipid", "d": []}, {"i": "EC:2.3.1.149", "l": "\"platelet-activating factor acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016463", "l": "P-type zinc transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(in) -> ADP + phosphate + Zn2+(out)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102630", "l": "gossypetin 8-methyl ester 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5,7-pentahydroxy-8-methoxyflavon-3-olate + S-adenosyl-L-methionine <=> gossypetin 3',8-dimethyl ether + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098699", "l": "structural constituent of presynaptic actin cytoskeleton", "d": ["The action of a molecule that contributes to the structural integrity of a presynaptic actin cytoskeleton."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045485", "l": "omega-6 fatty acid desaturase activity", "d": ["Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40240", "l": "ATP + CoA + dodecanedioate => AMP + diphosphate + dodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46814", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28504", "l": "H(+) + NADH + S-formylmycothiol => NAD(+) + S-(hydroxymethyl)mycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250880", "l": "botF HC:LC binds SV2A or B or C and GT1b on the target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30869", "l": "(indol-3-yl)acetate + 2 H(+) + NADH => H2O + indole-3-acetaldehyde + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097713", "l": "dolichol-phosphate-mannose synthase regulator activity", "d": ["Binds to and modulates the activity of dolichol-phosphate-mannose synthase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748996", "l": "GST dimers cleave AZA to 6MP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12762", "l": "precorrin-3B + S-adenosyl-L-methionine => 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60353", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone + O2 => CO + H(+) + N-octanoylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852317", "l": "PLK1 phosphorylates GTSE1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74798", "l": "N-methyl-(R)-salsolinol(in) <=> N-methyl-(R)-salsolinol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53758", "l": "allodeoxycholate + choloyl-CoA => allodeoxycholoyl-CoA + cholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37826", "l": "(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26172", "l": "1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = CoA + H(+) + mycothiol", "d": []}, {"i": "EC:2.3.1.189", "l": "\"mycothiol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018855", "l": "2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity", "d": ["Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57278", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA => a 2'-deoxyguanosine in DNA + glyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32892", "l": "(1S,5S)-alpha-pinene + H(+) + NADH + O2 => alpha-pinene oxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606789", "l": "ARSB hydrolyses DS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051007", "l": "squalene-hopene cyclase activity", "d": ["Catalysis of the reaction: squalene = hop-22(29)-ene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68214", "l": "1,2-dihexanoyl-3-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,2-dihexanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27495", "l": "3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + tricetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71348", "l": "chloride(out) + L-lysine(out) + 2 Na(+)(out) => chloride(in) + L-lysine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602549", "l": "Defective TLR3 does not bind viral dsRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9660557", "l": "RAS:GTP binds RAL GDS proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0005042", "l": "netrin receptor activity", "d": ["Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59696", "l": "D-cellotetraono-1,5-lactone + H2O = D-cellotetraonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51784", "l": "4-prenylphlorisovalerophenone + dimethylallyl diphosphate = deoxyhumulone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004122", "l": "cystathionine beta-synthase activity", "d": ["Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0015217", "l": "ADP transmembrane transporter activity", "d": ["Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392749", "l": "Transport of L1 into endosomes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045523", "l": "interleukin-27 receptor binding", "d": ["Binding to an interleukin-27 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59295", "l": "beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O <=> D-galactose + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73596", "l": "dCMP + H2O => dUMP + NH4+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694428", "l": "LMAN family proteins bind glycosylated cargo (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56460", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674529", "l": "AAMP binds to TBXA2R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15823", "l": "2 AH2 + CO2 + hydrogen cyanide => 2 A + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47090", "l": "3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701064", "l": "TRPV1 binds TRPV1 agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449829", "l": "IL11 binds IL11RA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20121", "l": "ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)", "d": []}, {"i": "EC:6.1.1.18", "l": "\"glutamine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35746", "l": "H(+) + NADPH + O2 + versicolorin B <=> 2 H2O + NADP(+) + versicolorin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73661", "l": "ADP(in) + ATP(out) + H(+)(in) + Mg(2+)(out) => ADP(out) + ATP(in) + H(+)(out) + Mg(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48801", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65793", "l": "fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32618", "l": "(6E)-8-oxogeraniol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017060", "l": "3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity", "d": ["Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14032", "l": "A + H2O + selenite <=> AH2 + selenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177930", "l": "GAB1 phosphorylation by EGFR kinase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53747", "l": "glycyl-tRNA(Ala) + H2O <=> glycine + H(+) + tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45630", "l": "holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein] => holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0031210", "l": "phosphatidylcholine binding", "d": ["Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013143", "l": "RAC1 GEFs activate RAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033288", "l": "ATPase-coupled hydroxyectoine transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + hydroxyectoine(out/in) = ADP + phosphate + hydroxyectoine(in/out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18823", "l": "acetylcholine + CoA => acetyl-CoA + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928602", "l": "NGEF binds EPHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990749", "l": "polynucleotide adenylyltransferase activator activity", "d": ["Increases the activity of the enzyme polynucleotide adenylyltransferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15558", "l": "ATP + H2O + Ni(2+)(out) => ADP + H(+) + Ni(2+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730840", "l": "Activation of RAC1 by VAV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18091", "l": "L-citrullyl-[protein] + NH4(+) => H2O + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41950", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.6", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050628", "l": "2-oxopropyl-CoM reductase (carboxylating) activity", "d": ["Catalysis of the reaction: acetoacetate + coenzyme M + NADP+ = 2-oxopropyl-coenzyme M + CO2 + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004636", "l": "phosphoribosyl-ATP diphosphatase activity", "d": ["Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H2O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070506", "l": "high-density lipoprotein particle receptor activity", "d": ["Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40631", "l": "H2O + trioctadecanoylglycerol = 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782893", "l": "TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25916", "l": "A + H2O + quinolin-6-ol = 6-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005163", "l": "nerve growth factor receptor binding", "d": ["Binding to a nerve growth factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14571", "l": "H2O + propanal => propane-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13251", "l": "2-oxopropyl-coenzyme M + H(+) + NADH => (R)-2-hydroxypropyl-coenzyme M + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22327", "l": "H2O + leukotriene A4 <=> leukotriene B4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:1901235", "l": "(R)-carnitine transmembrane transporter activity", "d": ["Enables the transfer of (R)-carnitine from one side of a membrane to the other."]}, {"i": "RHEA:34959", "l": "(R)-carnitine(in) = (R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672980", "l": "Dissociation of RAS:RAF complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730847", "l": "Hydrolysis of PIP2 by PLCG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938201", "l": "MYL9 gene transcription is stimulated by RUNX1:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71737", "l": "formate + succinyl-CoA => formyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956684", "l": "ITCH polyubiquitinates TP73 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68517", "l": "(2Z,6Z)-farnesyl diphosphate => beta-acoradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11805", "l": "an aromatic aldehyde + H2O + NAD(+) => an aromatic carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46921", "l": "(E)-cinnamate + H(+) => CO2 + styrene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22218", "l": "3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+) => (E)-caffeate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23441", "l": "4-chlorobenzoate + H2O => 4-hydroxybenzoate + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50297", "l": "N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase] => 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51619", "l": "ATP + formate + H(+) <=> CO2 + dATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70735", "l": "chloride(out) + glycine betaine(out) + 2 Na(+)(out) = chloride(in) + glycine betaine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49896", "l": "(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate = 5,10-dihydrophenazine-1,6-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20736", "l": "acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA", "d": []}, {"i": "EC:2.3.1.29", "l": "\"glycine C-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202703", "l": "CD47 binds SIRP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18536", "l": "5-hydroxy-L-tryptophan + H(+) <=> CO2 + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102037", "l": "4-nitrotoluene monooxygenase activity", "d": ["Catalysis of the reaction: H+ + 4-nitrotoluene + NADH + O2 <=> 4-nitrobenzyl alcohol + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70363", "l": "cyanurate + H2O = 1-carboxybiuret + H(+)", "d": []}, {"i": "EC:3.5.2.15", "l": "\"cyanuric acid amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693593", "l": "D-loop extension by DNA polymerases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665748", "l": "FMNL2 binds RHOC:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42329", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751013", "l": "Inactive G alpha (s) reassociates with G beta:gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58127", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21242", "l": "diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] => geranylgeranyl diphosphate + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199518", "l": "C3d-complexed antigen binds to complement receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71969", "l": "(S)-2-hydroxyglutarate(in) + 3 Na(+)(in) => (S)-2-hydroxyglutarate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56470", "l": "(3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067640", "l": "IL6 binds IL6R-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66738", "l": "ADP + beta-citrylglutamate(out) + H(+) + phosphate => ATP + beta-citrylglutamate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202731", "l": "JAM3 dimerises (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19402", "l": "methanol + NAD(+) => formaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018825", "l": "triethanolamine lyase activity", "d": ["Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74339", "l": "O-3-methylbutanoyl-(R)-carnitine(in) = O-3-methylbutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706287", "l": "Active FLT3 binds to ABL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29663", "l": "H(+)(in) + xanthine(in) = H(+)(out) + xanthine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947535", "l": "Cyclisation of GTP to precursor Z (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26522", "l": "(2S,3S)-2-methylcitrate = 2-methyl-trans-aconitate + H2O", "d": []}, {"i": "EC:4.2.1.117", "l": "\"2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997237", "l": "SH2B proteins bind JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635839", "l": "ULK3:SUFU dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41245", "l": "N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine => N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052577", "l": "germacrene-D synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-germacrene D + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381087", "l": "Dimerization of PERK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25114", "l": "phosphate + pyridoxine => H2O + pyridoxine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209828", "l": "Tryptophan is hydroxylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29090", "l": "(S)-malate + menaquinone-8 <=> menaquinol-8 + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264865", "l": "Caspase-mediated cleavage of Lamin A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9734730", "l": "ORC1 translocates to the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109701", "l": "PDPK1 binds PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52487", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A <=> (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70144", "l": "6alpha-hydroxy-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => 28-nortyphasterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68630", "l": "(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit] => phycoerythrobilin-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507869", "l": "Aquaporins passively transport glycerol into cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64993", "l": "acetyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209111", "l": "Translation of p14ARF mRNA is inhibited by miR-24 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299475", "l": "TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168376", "l": "STIM1 oligomerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1458433", "l": "Collagen type I degradation by MMP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047058", "l": "vitamin-K-epoxide reductase (warfarin-insensitive) activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179413", "l": "Activated PKC-alpha  activate MMP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.46", "l": "\"glycerophosphodiester phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61546", "l": "ent-kaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318415", "l": "ATF2 acetylates histone H2B, H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879221", "l": "PSTPIP1 binds Pyrin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21367", "l": "H2O + N-(6-aminohexanoyl)-6-aminohexanoate <=> 2 6-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11929", "l": "hydroxylamine + NH4(+) => H(+) + H2O + hydrazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69099", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine <=> H2O + kynurenate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.13", "l": "\"exo-(1->4)-alpha-D-glucan lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39387", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA = (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030351", "l": "inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate."]}, {"i": "REACT:R-HSA-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781953", "l": "YOD1 binds VCP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71695", "l": "2 H(+)(out) + L-alanyl-L-aspartate(out) = 2 H(+)(in) + L-alanyl-L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008010", "l": "structural constituent of chitin-based larval cuticle", "d": ["The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64283", "l": "(S)-1-phenylethylamine + pyruvate <=> acetophenone + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51976", "l": "an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46145", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24594", "l": "CDP-ethanolamine + diphosphate => CTP + H(+) + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070027", "l": "carbon monoxide sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of carbon monoxide (CO)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427337", "l": "MBD2 binds methylcytosine in chromatin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16258", "l": "alpha,alpha-trehalose + phosphate => alpha-D-glucose + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863718", "l": "AGFG1 binds VAMP7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102278", "l": "N,N'-diacetylchitobiose synthase activity", "d": ["Catalysis of the reaction: n H2O + chitin <=> N,N'-diacetylchitobiose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67201", "l": "H2O + N-acetyltyramine => acetate + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850961", "l": "PREX2 binds PTEN and inhibits it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203700", "l": "eNOS translocation from Golgi to Caveolae (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17633", "l": "a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate", "d": []}, {"i": "EC:3.2.1.31", "l": "\"beta-glucuronidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66950", "l": "alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CoA => acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61506", "l": "pelargonidin 3-O-beta-D-glucoside + UDP => pelargonidin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20225", "l": "(E)-caffeate + S-adenosyl-L-methionine = (E)-ferulate + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.68", "l": "\"caffeate O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047993", "l": "hydroxymalonate dehydrogenase activity", "d": ["Catalysis of the reaction: hydroxymalonate + NAD+ = H+ + NADH + oxomalonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25933", "l": "4-methylquinoline + A + H2O => 4-methylquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43235", "l": "H2O + isatin <=> H(+) + isatinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2203516", "l": "Alpha-1-Microglobulin is cleaved (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54080", "l": "5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73698", "l": "dADP(out) + H(+)(out) + phosphate(in) <=> dADP(in) + H(+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33599", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32337", "l": "(1S,4R)-fenchone + H(+) + NADPH => (1S,2S,4R)-endo-fenchol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66656", "l": "Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404200", "l": "IGF1,2 binds IGF1R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180606", "l": "Association of Vpu with CD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432956", "l": "BP230 is recruited to the hemidesmosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13867", "l": "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49312", "l": "2-trans,4-trans-xanthoxin + NAD(+) = 2-trans-(+)-abscisic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38211", "l": "hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373705", "l": "Caspase cleavage of DCC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176452", "l": "Degradation of ubiquitinated SMAD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22097", "l": "phosphate + RNA(n+1) => a ribonucleoside 5'-diphosphate + RNA(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709406", "l": "CO binds to Cytochrome c oxidase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55105", "l": "3-oxoheptanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyheptanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047930", "l": "glucosaminate ammonia-lyase activity", "d": ["Catalysis of the reaction: D-glucosaminate = 2-dehydro-3-deoxy-D-gluconate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236971", "l": "Peptide loading on MHC class I in phagosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30900", "l": "bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66160", "l": "hexanoyl-CoA + tyramine = CoA + H(+) + N-hexanoyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30315", "l": "1,7-dimethylxanthine + H(+) + NADH + O2 = 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42996", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (R)-cembrene A + diphosphate", "d": []}, {"i": "EC:4.2.3.150", "l": "\"cembrene A synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29010", "l": "H(+)(in) + Mn(2+)(in) <=> H(+)(out) + Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626046", "l": "p-GFAP binds EEF1A1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034257", "l": "nicotinamide riboside transmembrane transporter activity", "d": ["Enables the transfer of nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, from one side of a membrane to the other."]}, {"i": "RHEA:33163", "l": "beta-nicotinamide D-riboside(in) = beta-nicotinamide D-riboside(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605591", "l": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26464", "l": "3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine => 6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157353", "l": "NEXT1 is cleaved to produce NICD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52526", "l": "20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41708", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603784", "l": "PEX19:class I PMP binds PEX3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008659", "l": "(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187266", "l": "SCARA5 binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202692", "l": "PIP3 binds to RhoA and activates it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018546", "l": "nitrobenzene nitroreductase activity", "d": ["Catalysis of the reaction: nitrobenzene + 2 NADPH + 2 H+ = hydroxyaminobenzene + 2 NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47771", "l": "guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014449", "l": "RHOG binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74733", "l": "Insulin receptor de-phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34060", "l": "agroclavine + NADP(+) => didehydroagroclavine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72600", "l": "N-acetyl-L-aspartyl-L-glutamate(out) => N-acetyl-L-aspartyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1467466", "l": "ABCA4 mediates atRAL transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73169", "l": "CoA(in) + NAD(+)(out) => CoA(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45241", "l": "a (3E,5Z)-dienoyl-CoA => a (2E,4E)-(5,6-saturated)-dienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30236", "l": "H2O + L-glutamate 5-semialdehyde + NAD(+) => 2 H(+) + L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010096", "l": "Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67547", "l": "(9Z)-tetradecenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210290", "l": "Interaction of PECAM-1 and SHIP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47280", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53994", "l": "(14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43116", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22552", "l": "3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)", "d": []}, {"i": "EC:2.8.2.2", "l": "\"alcohol sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45353", "l": "9,10-epoxyoctadecanoate + H2O => 9,10-dihydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061675", "l": "RBL family protein binding", "d": ["Binding to a member of the rhamnose-binding lectin (RBL) family, a family of animal lectins that show specific binding activities to L-rhamnose or D-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32991", "l": "2 a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422454", "l": "Polysialylation of NCAM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509838", "l": "ITPA hydrolyses dITP to dIMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47006", "l": "L-threonyl-[protein] + phosphate => H2O + O-phospho-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28905", "l": "D-alanine(out) + H(+)(out) => D-alanine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13654", "l": "[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose => [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3159259", "l": "MMAA:MUT binds AdoCbl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693086", "l": "BACE1(46-501) translocates from Golgi lumen to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.46", "l": "\"L-arabinose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35619", "l": "L-idarate = D-glucarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37910", "l": "(9Z)-octadecenoate + O2 <=> (8E,10S)-10-hydroperoxy-octadeca-8-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061788", "l": "EGF repeat binding", "d": ["Binding to Epidermal Growth Factor (EGF) repeats."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706312", "l": "Active FLT3 binds to LCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56351", "l": "4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 <=> 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48480", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37682", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209271", "l": "N-HH moves from the cytosol to the extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17558", "l": "anthranilate + malonyl-CoA => CoA + N-malonylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61473", "l": "a sphingoid base + hexadecanoyl-CoA => an N-hexadecanoyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635868", "l": "ub-GLI is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199154", "l": "CD200 binds to CD200R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39975", "l": "2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164512", "l": "Second strand transfer by annealing complementary PBS sequences (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65740", "l": "2-oxoglutarate + nonyl sufate + O2 = CO2 + H(+) + nonanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65460", "l": "acetyl-CoA + hexan-1-ol = CoA + hexyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.73", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102979", "l": "homofuraneol oxidoreductase activity", "d": ["Catalysis of the reaction: homofuraneol + NADP <=> (2E)-2-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17427", "l": "acetyl-CoA + CO2 + NADPH => CoA + NADP(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36680", "l": "dTDP-6-deoxy-alpha-D-allose + NAD(+) => dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419462", "l": "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008401", "l": "retinoic acid 4-hydroxylase activity", "d": ["Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39557", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372542", "l": "Loading of dopamine into synaptic veiscles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205244", "l": "Recruitment of CBL to KIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38619", "l": "nicotinate beta-D-ribonucleotide + phenol = H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside", "d": []}, {"i": "EC:2.4.2.55", "l": "\"nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33926", "l": "(1R,4R)-5-oxo-1,2-campholide <=> [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5660666", "l": "CBP and p300 binds NF-kB complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57940", "l": "Fe-coproporphyrin III + H(+) + H2O2 = CO2 + 2 H2O + harderoheme III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13093", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65464", "l": "2-methylbutan-1-ol + butanoyl-CoA = 2-methylbutyl butanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34228", "l": "5-nitrosalicylate + O2 => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658435", "l": "RAS GAPs bind RAS:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10353", "l": "an N-acetylarylalkylamine + H2O => acetate + an aralkylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.79", "l": "\"succinate-semialdehyde dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20419", "l": "CO2 + coelenteramide + hnu => coelenterazine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854462", "l": "VLDLR binds VLDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41133", "l": "1-decanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-decanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110319", "l": "Elongation by POLH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.99.6", "l": "\"NAD(P)H-hydrate epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015431", "l": "ABC-type glutathione S-conjugate transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047927", "l": "gibberellin-44 dioxygenase activity", "d": ["Catalysis of the reaction: gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14998", "l": "deoxylimonoate + H2O => deoxylimononate D-ring-lactone + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39969", "l": "2-iminobutanoate => 2-aminobut-2-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44767", "l": "2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421201", "l": "inosine 5'-monophosphate (IMP) + L-aspartate + GTP => adenylosuccinate + GDP + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250220", "l": "Homodimerization of ERBB4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73435", "l": "apigenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + ladanein + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176175", "l": "Stalling of DNA replication fork and RPA binding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13642", "l": "H(+) + methane + NADPH + O2 => H2O + methanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592398", "l": "Activation of proMMP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73342", "l": "ATP + beta-alanine + H(+) <=> beta-alanyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40865", "l": "FADH2 + trans-2-heptadecenoyl-CoA => FAD + H(+) + heptadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55930", "l": "fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => fenbendazole + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68955", "l": "isoscopoletin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + scoparone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15865", "l": "AH2 + O2 + tryptamine = 4-hydroxytryptamine + A + H2O", "d": []}, {"i": "EC:1.14.99.59", "l": "\"tryptamine 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3209165", "l": "ID1 sequesters ETS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52161", "l": "(E)-phenylacetaldehyde oxime => (Z)-phenylacetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2995330", "l": "COX10 transforms heme to heme O (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869694", "l": "oxPL binds CD14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714481", "l": "RAC2 binds effectors at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017098", "l": "sulfonylurea receptor binding", "d": ["Binding to a sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5669158", "l": "NF2 binds PAK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26283", "l": "acetaldehyde + Co-precorrin-5B + H(+) => Co-precorrin-5A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193650", "l": "p75NTR binds to NADE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34849", "l": "5,6,7,8-tetrahydromonapterin + NADP(+) => 7,8-dihydromonapterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38012", "l": "chlorophyll a + H2O => chlorophyllide a + H(+) + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047610", "l": "acetylsalicylate deacetylase activity", "d": ["Catalysis of the reaction: acetylsalicylate + H2O = acetate + H+ + salicylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174367", "l": "GCL ligates L-Glu to L-Cys (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62640", "l": "[mycoredoxin]-L-dithiol + a hydroperoxide = [mycoredoxin]-L-disulfide + an alcohol + H2O", "d": []}, {"i": "EC:1.11.1.29", "l": "\"mycoredoxin-dependent peroxiredoxin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008260", "l": "succinyl-CoA:3-oxo-acid CoA-transferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166168", "l": "TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25356", "l": "2-hydroxyphytanoyl-CoA => 2,6,10,14-tetramethylpentadecanal + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47422", "l": "(2E)-glutaconyl-CoA + AH2 => A + glutaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.180", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49679", "l": "H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 <=> H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62767", "l": "4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13421", "l": "an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate = an N-acylneuraminate 9-phosphate + phosphate", "d": []}, {"i": "EC:2.5.1.57", "l": "\"N-acylneuraminate-9-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72532", "l": "ATP + H2O + methyl beta-D-galactoside(out) => ADP + H(+) + methyl beta-D-galactoside(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49796", "l": "an N-(fatty acyl)-glycine + H2O = a fatty acid + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68866", "l": "alpha-D-glucose + D-glucose => H2O + isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30014", "l": "ATP + beta-D-galactose(out) + H2O <=> ADP + beta-D-galactose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043870", "l": "N-acetyl-gamma-aminoadipyl-phosphate reductase activity", "d": ["Catalysis of the reaction: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP+ + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696960", "l": "USP49 deubiquitinates H2B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051035", "l": "DNA transmembrane transporter activity", "d": ["Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110322", "l": "Formation of Pol zeta complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68225", "l": "2-oxoglutarate + H(+) + O2 + prekainate => CO2 + H2O + kainate lactone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23000", "l": "(R)-pantoate + NAD(+) = (R)-4-dehydropantoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.106", "l": "\"pantoate 4-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12885", "l": "GDP-alpha-D-mannose + queuosine(34) in tRNA(Asp) = GDP + H(+) + O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp)", "d": []}, {"i": "EC:2.4.1.110", "l": "\"tRNA-queuosine alpha-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11136", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "d": []}, {"i": "EC:2.4.3.3", "l": "\"alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818577", "l": "TASP1 cleaves KMT2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55443", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27823", "l": "hydrogen sulfide + O-acetyl-L-homoserine => acetate + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18108", "l": "ATP + Ca(2+)(in) + H2O <=> ADP + Ca(2+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008785", "l": "alkyl hydroperoxide reductase activity", "d": ["Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251557", "l": "Expression of AMER1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806613", "l": "Keratin tetramers bind to form unit length filaments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48881", "l": "a quinone + CO + H2O => a quinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14382", "l": "4-guanidinobutanal + H2O + NAD(+) => 4-guanidinobutanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56639", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25832", "l": "1D-chiro-inositol + NAD(+) = H(+) + NADH + scyllo-inosine", "d": []}, {"i": "EC:1.1.1.369", "l": "\"D-chiro-inositol 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.264511229695032", "identifiers": [{"i": "GO:0016812", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114553", "l": "Activation of conventional Protein Kinase C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12947", "l": "biphenyl-2-ol + H(+) + sulfite => 2'-hydroxybiphenyl-2-sulfinate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75609", "l": "plasmodiophorol B => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0032546", "l": "deoxyribonucleoside binding", "d": ["Binding to a deoxyribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to deoxyribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47866", "l": "dioctanoylglycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22507", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55705", "l": "glycine + hydrogen sulfide + NAD(+) => ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0008834", "l": "di-trans,poly-cis-decaprenylcistransferase activity", "d": ["Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328145", "l": "Laminin-111 binds collagen type IV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166792", "l": "Conversion of C2 into C2a and C2b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159733", "l": "Furin cleaves pro-factor X to factor X (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66659", "l": "Cu(2+)(out) + L-ascorbate(in) <=> Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16137", "l": "2'-deoxymugineate + NADP(+) = 3''-deamino-3''-oxonicotianamine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090079", "l": "GLB1 hydrolyses linker chain(2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353314", "l": "XP-C-RAD23B heterodimer binds to damaged DNA site with lesion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23481", "l": "2-methylene-3-methylsuccinate => dimethylmaleate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61621", "l": "[(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose => [(1->2)-beta-D-mannosyl](n+1) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648268", "l": "HTR1A binds HTR1A antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173739", "l": "Spontaneous hydrolysis of C3 thioester (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58908", "l": "7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH = C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610327", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN3B (GRIN3B) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977363", "l": "Factor H binds to C3bBb (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46660", "l": "H(+) + NADPH + progesterone = 5beta-pregnan-3,20-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27871", "l": "(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57952", "l": "H(+) + NADH + O2 + phenol = catechol + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.244", "l": "\"phenol 2-monooxygenase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015195", "l": "L-threonine transmembrane transporter activity", "d": ["Enables the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614614", "l": "Cysteine is degraded to serine and H2S (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61837", "l": "ergosterol + UDP-alpha-D-glucose => ergosteryl 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.21", "l": "\"dolichyl-phosphooligosaccharide-protein glycotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15835", "l": "4-hydroxybenzaldehyde + CO2 + H2O2 => (S)-4-hydroxymandelate + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11194", "l": "a (2R)-2-hydroxycarboxylate + a halide anion + H(+) => an (S)-2-haloacid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018508", "l": "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64458", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine => L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166038", "l": "GPI-bound CD14 binds LPS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350901", "l": "Iodide is organified (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683801", "l": "CHEK2 phosphorylates BRCA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941895", "l": "Formation of CDK4/6:CCND complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58877", "l": "4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39520", "l": "3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32168", "l": "ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine => aerobactin + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30468", "l": "(2Z,6Z)-farnesyl diphosphate => (+)-endo-beta-bergamotene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24229", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) => 4-methylcatechol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51120", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2 = (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033795", "l": "betaine reductase activity", "d": ["Catalysis of the reaction: acetyl phosphate + trimethylamine + thioredoxin disulfide = N,N,N-trimethylglycine + phosphate + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.20", "l": "\"peptidyl-Lys metalloendopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005988", "l": "MECP2 binds the TRPC3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23170", "l": "8-oxocoformycin + H(+) + NADPH => coformycin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59161", "l": "ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] => AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47358", "l": "an aliphatic alcohol + H(+) + octanoate => an octanoate ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23193", "l": "Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42961", "l": "H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain] => NADH + 2 oxidized [nitric oxide reductase rubredoxin domain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11961", "l": "2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate => (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0008235", "l": "metalloexopeptidase activity", "d": ["Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.-.-", "l": "\"Catalysing the translocation amino acids and peptides\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875531", "l": "MET binds TNS4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691421", "l": "BTK binds BTK inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163617", "l": "G alpha (s) activates adenylate cyclase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28611", "l": "H2O + XTP => diphosphate + H(+) + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59964", "l": "L-seryl-[protein] + octanoyl-CoA = CoA + O-octanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428534", "l": "Recruitment of Profilin by Ena/VASP proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42852", "l": "3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine = (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.3.1.244", "l": "\"2-methylbutanoate polyketide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24305", "l": "(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) => (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706330", "l": "Active FLT3 binds to SOCS6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14057", "l": "a 1,2-diacyl-sn-glycerol + a glycerophospholipid = a monoacylglycerophospholipid + a triacyl-sn-glycerol", "d": []}, {"i": "EC:2.3.1.158", "l": "\"phospholipid:diacylglycerol acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0048038", "l": "quinone binding", "d": ["Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71647", "l": "a medium-chain (3S)-3-hydroxyacyl-CoA = a medium-chain (2E)-enoyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.74", "l": "\"medium-chain-enoyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617927", "l": "FOXO4 binds ATXN3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004061", "l": "arylformamidase activity", "d": ["Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5681980", "l": "ATG12 binds ATG7 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23507", "l": "adenosylcob(III)inamide + H2O <=> (R)-1-aminopropan-2-ol + adenosylcob(III)yrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168923", "l": "Collagen type XVIII endostatin release (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19445", "l": "2,3-dihydroxyindole + O2 = anthranilate + CO2 + H(+)", "d": []}, {"i": "EC:1.13.11.23", "l": "\"2,3-dihydroxyindole 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71212", "l": "chlorate(out) + 2 Na(+)(out) => chlorate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63387", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814374", "l": "Kazrin binds periplakin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668545", "l": "NIK autophosphorylates on T559 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25623", "l": "tuberculosinyl diphosphate => geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74711", "l": "Phosphorylation of IRS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190065", "l": "Activated TrkA receptor internalizes to endosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35640", "l": "(4S)-4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031842", "l": "type 1 neuropeptide Y receptor binding", "d": ["Binding to a type 1 neuropeptide Y receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36435", "l": "a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn-glycero-3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60652", "l": "an N-(acyl)-sphingosylphosphocholine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28331", "l": "H2O + ITP => H(+) + IDP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420243", "l": "GHRH receptor binds GHRH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692539", "l": "HRH1 binds HRH1 inverse agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54436", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 = a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668335", "l": "CHMP7 binds LEMD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392206", "l": "G alpha (i) inhibits adenylate cyclase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51546", "l": "D-xylulose => D-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25720", "l": "H(+) + N,N-dihydroxy-L-trihomomethionine => (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61940", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose = 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3782655", "l": "HDAC10 deacetylates histone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2152276", "l": "Secretion of transmembrane collagens (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21638", "l": "4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP => (E)-4-coumarate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42984", "l": "(+)-copalyl diphosphate = diphosphate + pimara-8(14),15-diene", "d": []}, {"i": "EC:4.2.3.147", "l": "\"pimaradiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49219", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O <=> 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58801", "l": "3',3'-cGAMP + H2O => 5'-pApG-3' + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019149", "l": "3-chloro-D-alanine dehydrochlorinase activity", "d": ["Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67954", "l": "an omega-hydroxy-very-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607734", "l": "PKC-delta translocates to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.299", "l": "\"malate dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46632", "l": "7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH = 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44959", "l": "(2E)-hexenoyl-CoA + H(+) + NADPH <=> hexanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806425", "l": "TP53 stimulates FANCC expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64709", "l": "butan-1-ol + NADP(+) => butanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33418", "l": "bornane-2,6-dione + H2O <=> [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35378", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O <=> (beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9688459", "l": "RIPK3 binds HSP90:CDC37 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57565", "l": "(+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983259", "l": "Kinesins move along microtubules consuming ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55533", "l": "H(+) + H2O + L-phenylalanine + O2 => 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23670", "l": "AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase] => apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13809", "l": "aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate", "d": []}, {"i": "EC:2.5.1.35", "l": "\"aspulvinone dimethylallyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29828", "l": "Mg(2+)(in) => Mg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37653", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0140906", "l": "halogenase activity", "d": ["Catalysis of the reaction: R-CH + a halogen + oxygen donor = R-C-halogen +H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21371", "l": "H2O + O2 + urate <=> 5-hydroxyisourate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016989", "l": "sigma factor antagonist activity", "d": ["The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-169895", "l": "Crk's SH3 domain engages C3G (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614605", "l": "Persulfide sulfur is dioxygenated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74761", "l": "3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine => isorhamnetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22535", "l": "(2E)-octenedioyl-CoA + H2O <=> (3S)-hydroxyoctanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63455", "l": "3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin <=> GMP + H(+) + oxidized 3PG-factor420-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39821", "l": "2-hydroxydocosanoate + 2 Fe(III)-[cytochrome b5] + H2O => docosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909720", "l": "IFN alpha/beta binds to IFNAR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9604308", "l": "NICD4 traffics to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39440", "l": "(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA => (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23863", "l": "acetyl-CoA + deacetylcephalosporin C <=> cephalosporin C + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35238", "l": "H(+)(out) + tetracycline(in) <=> H(+)(in) + tetracycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696605", "l": "USP12, USP26 deubiquitinate AR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649733", "l": "mature p21 RAS binds GDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52244", "l": "4 H(+) + 4 Mn(2+) + O2 = 2 H2O + 4 Mn(3+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.5", "l": "\"L-threonine aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399712", "l": "Activation of Ca permeable AMPA receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73585", "l": "CTP(in) + UDP(out) => CTP(out) + UDP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63264", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50632", "l": "a 2-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52726", "l": "a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + an aliphatic (Z)-desulfo-glucosinolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046562", "l": "glucose oxidase activity", "d": ["Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70743", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56559", "l": "(2E,6E)-farnesyl diphosphate <=> delta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16793", "l": "H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2", "d": []}, {"i": "EC:4.1.1.36", "l": "\"phosphopantothenoylcysteine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466828", "l": "Defective RBP4 does not bind atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29469", "l": "H(+)(in) + K(+)(out) => H(+)(out) + K(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37991", "l": "delta-tocopherol + S-adenosyl-L-methionine = beta-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9619355", "l": "CaMKK autophosphorylates in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019769", "l": "low-affinity IgE receptor activity", "d": ["Combining with low affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74606", "l": "CMP(out) + UDP-alpha-D-galactose(in) <=> CMP(in) + UDP-alpha-D-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63017", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35678", "l": "H(+) + L-serine + tetradecanoyl-CoA <=> 3-oxohexadecasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17271", "l": "H(+) + S-adenosyl-L-homocysteine + tylosin => macrocin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112434", "l": "Formation of DSIF complex  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44187", "l": "D-sedoheptulose 7-phosphate <=> 2-epi-5-epi-valiolone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0140934", "l": "histone deubiquitinase activity", "d": ["A deubiquitinase that cleaves ubiquitin from a histone protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879907", "l": "Tyrosine kinases phosphorylate the receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8865182", "l": "OTUD7A hydrolyses K11diUb (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047888", "l": "fatty acid peroxidase activity", "d": ["Catalysis of the reaction: 2 H2O2 + H+ + palmitate = CO2 + 3 H2O + pentadecanal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684016", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39677", "l": "3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA => (9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097100", "l": "supercoiled DNA binding", "d": ["Binding to supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66979", "l": "alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose <=> alpha-D-Abe-(1->3)-alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029471", "l": "Hydrolysis of PC to PA by PLD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416690", "l": "SEMA4A binds to PLXND1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12332", "l": "ATP + Fe(3+)(out) + H2O = ADP + Fe(3+)(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.2.2.7", "l": "\"ABC-type Fe(3+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64470", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH => (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44367", "l": "2-epi-5-epi-valiolone + ATP <=> 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213017", "l": "Auto-ubiquitination of TRAF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73555", "l": "(E,E)-feruperate + O2 + reduced [NADPH--hemoprotein reductase] = (E,E)-piperate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189062", "l": "lactose + H2O => D-glucose + D-galactose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23754", "l": "ADP + all-trans-undecaprenyl phosphate + H(+) => all-trans-undecaprenol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21944", "l": "ATP + D-cellobiose = 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.85", "l": "\"beta-glucoside kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42262", "l": "3-oxononanoyl-[ACP] + CO2 + CoA => H(+) + heptanoyl-CoA + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56020", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.-.-.-", "l": "\"Translocases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647994", "l": "RAS proteins are depalmitoylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35379", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.8.1.-", "l": "\"Hydro-lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26377", "l": "GTP = cyclic pyranopterin phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19139", "l": "6beta-hydroxyestradiol-17beta + A + H2O => 17beta-estradiol + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67289", "l": "ATP + 12 H(+) + L-leucine + 8 malonyl-CoA + 9 NADPH + 4 S-adenosyl-L-methionine => (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + AMP + 8 CO2 + 8 CoA + diphosphate + 7 H2O + 9 NADP(+) + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21427", "l": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) <=> 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23158", "l": "(indol-3-yl)acetonitrile + H2O => (E)-(indol-3-yl)acetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9617595", "l": "SGTA binds mislocalized membrane protein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373711", "l": "DCC interaction with Netrin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58277", "l": "6 ATP => cyclic hexaadenylate + 6 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72730", "l": "UDP-alpha-D-glucuronate(in) + UMP(out) <=> UDP-alpha-D-glucuronate(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24465", "l": "2-dehydro-3-deoxy-6-phospho-D-galactonate => D-glyceraldehyde 3-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.3.1", "l": "\"beta-galactoside alpha-(2,6)-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60328", "l": "L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.360", "l": "\"[histone H3]-lysine(79) N-trimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210426", "l": "Glutamate synaptic vesicle docking and priming (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983153", "l": "E1 mediated ubiquitin activation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022770", "l": "MECP2 binds SGK1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509827", "l": "ITPA hydrolyses ITP to IMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20239", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+) => (1S,4S)-5-oxo-1,2-campholide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22360", "l": "D-glutamate = 5-oxo-D-proline + H2O", "d": []}, {"i": "EC:4.2.1.48", "l": "\"D-glutamate cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001733", "l": "galactosylceramide sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-606289", "l": "New CENPA-containing nucleosomes are deposited at the centromere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34138", "l": "cannabigerolate + O2 <=> Delta(9)-tetrahydrocannabinolate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51019", "l": "7,8-dihydroneopterin 3'-phosphate <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17964", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> H2O + leukotriene A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8957241", "l": "TP73 tetramer translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19869", "l": "an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.13", "l": "\"glycine N-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0036361", "l": "racemase activity, acting on amino acids and derivatives", "d": ["Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607722", "l": "Active NIK phosphorylates IKKA dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27693", "l": "ATP + dGDP <=> ADP + dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5444511", "l": "Formation of MSH2:MSH3 Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656356", "l": "Defective SLC5A1 does not cotransport Glc and Na+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17935", "l": "a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine => a 7-hydroxyisoflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59426", "l": "benzaldehyde + H2O2 + NH4(+) => benzylamine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43506", "l": "2,5-diformylfuran + H2O2 => 5-hydroxymethylfurfural + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25891", "l": "dihydroxyacetone phosphate + iminosuccinate <=> H(+) + 2 H2O + phosphate + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67679", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49087", "l": "(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358619", "l": "EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25695", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30338", "l": "CTP + H(+) + H2O <=> NH4(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69404", "l": "uracil(in) = uracil(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196929", "l": "FLAD1 phosphorylates FMN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72368", "l": "estrone 3-sulfate(out) + succinate(in) => estrone 3-sulfate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362416", "l": "Frataxin binds iron (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683735", "l": "CHEK2 is recruited to DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74914", "l": "a (2E)-enoyl fatty acid + ATP + holo-[ACP] <=> a (2E)-enoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16031", "l": "beta-alanine + urea => 3-guanidinopropanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180905", "l": "Association of Vpr with ANT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43303", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805470", "l": "AMPK phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047200", "l": "tetrahydrodipicolinate N-acetyltransferase activity", "d": ["Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = L-2-acetamido-6-oxopimelate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295599", "l": "SPRY2 translocates to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798374", "l": "DYRK2 phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67701", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39401", "l": "(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2855047", "l": "Hydrolysis of internal thioester in C4b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33733", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56029", "l": "3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74860", "l": "dopamine + formaldehyde => H2O + norsalsolinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57208", "l": "glyoxal + L-cysteinyl-[protein] = S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654569", "l": "Activated FGFR1 binds FRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013631", "l": "NICD3 binds RBPJ and MAML in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69193", "l": "ATP + L-glutamate + L-glutamyl-[tubulin] => ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30529", "l": "ADP + ATP + 2 H(+) => H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48962", "l": "[thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O => [thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67956", "l": "(S)-2-chloropropanoate + H2O = (R)-lactate + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45368", "l": "H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43998", "l": "a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate => 2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2090079", "l": "GLB1 hydrolyses linker chain(2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813626", "l": "LEAP2 binds bacteria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47107", "l": "5,10-methylenetetrahydromethanopterin + glycine + H2O <=> 5,6,7,8-tetrahydromethanopterin + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16909", "l": "2 Fe(III)-[cytochrome c] + glycine + H2O = 2 Fe(II)-[cytochrome c] + glyoxylate + 2 H(+) + NH4(+)", "d": []}, {"i": "EC:1.4.2.1", "l": "\"glycine dehydrogenase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400204", "l": "PPARA binds RXRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32592", "l": "(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O => (3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1011598", "l": "DOCKs bind to RhoGEFs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654163", "l": "Activated FGFR4 binds PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18589", "l": "[glutamine synthetase]-L-tyrosine + ATP = [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate", "d": []}, {"i": "EC:2.7.7.42", "l": "\"[glutamine synthetase] adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13933", "l": "all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31875", "l": "(S)-2,3-epoxysqualene = marneral", "d": []}, {"i": "EC:5.4.99.53", "l": "\"marneral synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20468", "l": "[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42603", "l": "AH2 + prostaglandin G2 <=> A + H2O + prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9728664", "l": "GLP1R binds GLP1R agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58142", "l": "AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) => acetyl-AMP + cytidine(34) in elongator tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419841", "l": "Light stimulates opsin receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47101", "l": "choloyl-CoA + taurine => CoA + H(+) + taurocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450088", "l": "GLUT1 tetramer binds 4xATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901006", "l": "Binding of Malectin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0015440", "l": "ABC-type peptide transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67790", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a cardiolipin => 2 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.-", "l": "\"Methyltransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637641", "l": "Rv2779c binds TLR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74273", "l": "a 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+) => an alpha-Kdo-(2->6)-lipid IVA + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50343", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone <=> 1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71245", "l": "chloride(in) + hypotaurine(in) + 2 Na(+)(in) => chloride(out) + hypotaurine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12771", "l": "2-dehydro-D-gluconate + AH2 => A + D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46679", "l": "(4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+) <=> (6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0004354", "l": "glutamate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.134", "l": "\"beta-amyrin 24-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72648", "l": "1,6-dihydroxyphenazine + NADPH + O2 => 1,6-dihydroxyphenazine N(5)-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63007", "l": "(11Z,14Z)-eicosadienamide + H2O <=> (11Z,14Z)-eicosadienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41224", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202721", "l": "JAM2 binds JAM3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31437", "l": "(+)-alpha-santalene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34675", "l": "CTP + N,N-diacetyllegionaminate = CMP-N,N-diacetyllegionaminate + diphosphate", "d": []}, {"i": "EC:2.7.7.82", "l": "\"CMP-N,N'-diacetyllegionaminic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62615", "l": "adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74001", "l": "diphosphate + peniprequinolone => dimethylallyl diphosphate + quinolinone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52258", "l": "5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine => a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013143", "l": "RAC1 GEFs activate RAC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40268", "l": "(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) => 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38003", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate = 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate", "d": []}, {"i": "EC:2.5.1.116", "l": "\"homogentisate geranylgeranyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65961", "l": "ATP + H2O + leukotriene C4(out) => ADP + H(+) + leukotriene C4(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948027", "l": "RNASEs bind bacterial phospholipids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686625", "l": "LAIR1 binds collagen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987223", "l": "IL10RB binds TYK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549322", "l": "OCT1 transports organic cations out of hepatic cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0000406", "l": "double-strand/single-strand DNA junction binding", "d": ["Binding to a DNA segment that contains double-stranded DNA flanked by a region of single-stranded DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517846", "l": "TLR2-1 :TLR1-1 binds to triacyl lipopeptide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41969", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) => a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66520", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27430", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 1,2-diacyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53189", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O => 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2545196", "l": "FN1 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5252001", "l": "ATP1B4 binds SNW1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689000", "l": "AADAC deacetylates PHEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035954", "l": "Defective CYP17A1 does not 17-hydroxylate P4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63117", "l": "peroxynitrite => nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22808", "l": "6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2", "d": []}, {"i": "EC:1.17.3.3", "l": "\"6-hydroxynicotinate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416698", "l": "SEMA5A binds to PLXNB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473596", "l": "Collagen type I degradation by MMP15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14923", "l": "1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP => (indol-3-yl)acetate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954056", "l": "E2F6 binds TFDP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22356", "l": "diphosphate + oxaloacetate = CO2 + phosphate + phosphoenolpyruvate", "d": []}, {"i": "EC:4.1.1.38", "l": "\"phosphoenolpyruvate carboxykinase (diphosphate)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47917", "l": "ATP + N-hexanoyl-(4R)-hydroxysphinganine => ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021068", "l": "PalmS-ESRs bind CAVs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13013", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.87", "l": "\"N-acetyllactosaminide 3-alpha-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607722", "l": "Active NIK phosphorylates IKKA dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65457", "l": "2-methylbutan-1-ol + acetyl-CoA => 2-methylbutyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047273", "l": "galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide."]}]}
{"type": "biolink:MolecularActivity", "ic": "74.79713023523334", "identifiers": [{"i": "GO:1901265", "l": "nucleoside phosphate binding", "d": ["Binding to nucleoside phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948027", "l": "RNASEs bind bacterial phospholipids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102243", "l": "ATP:geranylgeraniol phosphotransferase activity", "d": ["Catalysis of the reaction: (E,E)-geranylgeraniol + ATP = H+ + all-trans-geranyl-geranyl monophosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41121", "l": "1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28628", "l": "O2 + reduced [NADPH--hemoprotein reductase] + solavetivol => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64687", "l": "L-threonyl-[protein] + UDP-alpha-D-glucose <=> 3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18568", "l": "19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine <=> 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.120", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29052", "l": "2 H(+)(in) + H2 + menaquinone-8 => 2 H(+)(out) + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73444", "l": "2-oxoglutarate + gardenin B + O2 => CO2 + formaldehyde + H(+) + nevadensin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102064", "l": "gamma-curcumene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> gamma-curcumene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57913", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) => H(+) + L-glutaminyl-tRNA(Gln) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49195", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373747", "l": "Phosphorylation of nephrin by FYN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46036", "l": "2'-deoxycytidine + UTP = dCMP + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24985", "l": "(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849908", "l": "SALM4 binds flotillin-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42856", "l": "1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15088", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22073", "l": "ATP + L-ribulose => ADP + H(+) + L-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629365", "l": "NEIL3 recognizes and binds to spiroiminodihydantoin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0003913", "l": "DNA photolyase activity", "d": ["Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33436", "l": "fecosterol => episterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67384", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] = 5beta-cholestane-3alpha,7alpha,25-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21860", "l": "3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate = adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate", "d": []}, {"i": "EC:2.8.2.28", "l": "\"quercetin-3,3'-bissulfate 7-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.11", "l": "\"pterin deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70623", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875568", "l": "RAPGEF1 activates RAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57811", "l": "1-chloro-3-nitrobenzene + NADH + O2 <=> 3-chlorocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035034", "l": "histone acetyltransferase regulator activity", "d": ["Binds to and modulates the activity of histone acetyltransferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11520", "l": "(-)-menthol + UDP-alpha-D-glucose = (-)-menthyl beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.127", "l": "\"monoterpenol beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791138", "l": "Expression of TPP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53195", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O <=> 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877308", "l": "Dephosphorylation of JAKs by PTPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60149", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate => (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031435", "l": "mitogen-activated protein kinase kinase kinase binding", "d": ["Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73581", "l": "(E,E)-piperoyl-CoA + AMP + H(+) => (E,E)-piperoyl-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55436", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol", "d": []}, {"i": "EC:1.14.14.62", "l": "\"salviol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59020", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043866", "l": "adenylyl-sulfate reductase (thioredoxin) activity", "d": ["Catalysis of the reaction: AMP + sulfite + thioredoxin disulfide = 5'-adenylyl sulfate + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114560", "l": "Adhesion of integrin alphaIIbbeta3 to fibrin network (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41988", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) = 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2179413", "l": "Activated PKC-alpha  activate MMP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61674", "l": "diphosphate + L-cysteinyl-5'-AMP => ATP + H(+) + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67264", "l": "(2S,4S)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine = (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192061", "l": "CYP46A1 24-hydroxylates CHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17041", "l": "adenosine 5'-phosphosulfate + H2O = AMP + 2 H(+) + sulfate", "d": []}, {"i": "EC:3.6.2.1", "l": "\"adenylylsulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52066", "l": "(9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+) => 13-(9Z-octadecenoyloxy)-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39226", "l": "(3R)-hydroxyoctacosanoyl-CoA <=> (2E)-octacosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31865", "l": "friedelin => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004378", "l": "GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity", "d": ["Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60871", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O <=> a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73038", "l": "Co(2+)(out) + H(+)(out) <=> Co(2+)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606602", "l": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61738", "l": "rubusoside + UDP => steviolmonoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57051", "l": "AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610726", "l": "The IFT-A complex recruits TULP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49075", "l": "dibenzothiophene + 2 FMNH2 + 2 O2 <=> dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33099", "l": "acetyl-CoA + spermine = CoA + H(+) + N(1)-acetylspermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12902", "l": "D-arginine + H2O => D-ornithine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110218", "l": "Cleavage of uracil by TDG glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251922", "l": "PLCG1 phosphorylation by p-EGFR:p-ERBB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46237", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61208", "l": "8-nitro-cGMP + L-cysteinyl-[protein] = H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61188", "l": "quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose = H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789092", "l": "NOX2 generates superoxide anion from oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1471314", "l": "HNP1-3 bind CD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32203", "l": "(R)-synephrine = (4-hydroxyphenyl)acetaldehyde + methylamine", "d": []}, {"i": "EC:4.2.1.88", "l": "\"synephrine dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450533", "l": "PKCdelta phosphorylates HuR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39135", "l": "(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2 = (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26235", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol => (2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15239", "l": "2 Fe(II)-[cytochrome c2] + H(+) + NADP(+) => 2 Fe(III)-[cytochrome c2] + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10174", "l": "2 (R)-3-hydroxybutanoate + H(+) => (3R)-hydroxybutanoate dimer + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013159", "l": "CDC42 GEFs activate CDC42 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74482", "l": "(-)-cyclopeptine + 2-oxoglutarate + O2 <=> (Z)-dehydrocyclopeptine + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44137", "l": "dodecanoyl-CoA + hexadecan-1-ol => CoA + hexadecanyl dodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052752", "l": "reduced coenzyme F420:heterodisulfide oxidoreductase activity", "d": ["Catalysis of the reaction: reduced coenzyme F420 + CoB-S-S-CoM = coenzyme F420 + CoM-SH + CoB-SH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65813", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2 => A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031516", "l": "far-red light photoreceptor activity", "d": ["The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 730nm. The response may involve a change in conformation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374896", "l": "Uptake of Noradrenaline (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25037", "l": "ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec)", "d": []}, {"i": "EC:2.7.1.164", "l": "\"O-phosphoseryl-tRNA(Sec) kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236970", "l": "Proteasomal clevage of exogenous antigen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0032029", "l": "myosin tail binding", "d": ["Binding to the tail region of a myosin heavy chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69111", "l": "2-oxo-3-sulfanylpropanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11565", "l": "4-O-beta-D-glucopyranosyl-D-gluconate + phosphate => alpha-D-glucose 1-phosphate + D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420243", "l": "GHRH receptor binds GHRH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64076", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 = 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60508", "l": "a guanosine in mRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855232", "l": "RELN:VLDLR binds DAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19142", "l": "all-trans-retinol => 11-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63134", "l": "cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-methyl glutathione => apo-[alkylcobalamin reductase] + glutathione + methylcob(III)alamin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222353", "l": "Protonation of superoxide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602712", "l": "TICAM1 deficiency blocks TLR3 pathway (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0035673", "l": "oligopeptide transmembrane transporter activity", "d": ["Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19686", "l": "(E)-feruloyl-CoA + tyramine => CoA + H(+) + N-[(E)-feruloyl]tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951644", "l": "Release of mature NEDD8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11028", "l": "ATP + D-mannose = ADP + D-mannose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74534", "l": "AH2 + archaetidylglycerol + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaetidylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28436", "l": "((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP] => (9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73305", "l": "H(+)(out) + oxaloacetate(in) + phosphate(out) => H(+)(in) + oxaloacetate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090711", "l": "FMN hydrolase activity", "d": ["Catalysis of the reaction: FMN + H2O = riboflavin + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186785", "l": "PDGF-AA clevage by Furin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004895", "l": "cell adhesion receptor activity", "d": ["The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell and to initiate intracellular signaling. Cell adhesion receptors include integrins and cadherins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37246", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19391", "l": "(E)-feruloyl-CoA + ADP + phosphate => (E)-ferulate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36153", "l": "(E)-cinnamyl acetate + CoA => (E)-cinnamyl alcohol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11026", "l": "ADP + 2 H(+) + phosphoramidate => ATP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28825", "l": "H(+)(out) + L-galactonate(out) => H(+)(in) + L-galactonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483089", "l": "PE is converted to PS by PTDSS2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043336", "l": "site-specific telomere resolvase activity", "d": ["Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39471", "l": "(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15315", "l": "acetaldehyde + NH4(+) => ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13961", "l": "ATP + H2O + Mg(2+) + protoporphyrin IX = ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate", "d": []}, {"i": "EC:6.6.1.1", "l": "\"magnesium chelatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55094", "l": "H(+) + sucrose + UDP => D-fructose + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696810", "l": "RNase P cleaves the 5' end of pre-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26330", "l": "(8S)-8-amino-7-oxononanoate + L-lysine => (7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928640", "l": "PAKs phosphorylate MLC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42286", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246514", "l": "botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031831", "l": "type 5B serotonin receptor binding", "d": ["Binding to a type 5B serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1222376", "l": "NOX2 generates superoxide from oxygen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62596", "l": "(S)-8-oxocitronellyl enol + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24673", "l": "H2O + hypoxanthine + NAD(+) <=> H(+) + NADH + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39547", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA = (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44170", "l": "dodecanal + H2O + NAD(+) => dodecanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71303", "l": "RPE dimers isomerise RU5P to XY5P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16047", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44199", "l": "3-methylundecanoate + ATP + CoA <=> 3-methylundecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74316", "l": "O-isobutanoyl-(R)-carnitine(in) => O-isobutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112437", "l": "Formation of NELF complex  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61041", "l": "(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] => (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731051", "l": "SARS-CoV-1 3b binds to RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964773", "l": "OXGR1 binds 2OG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39528", "l": "(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH => (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15594", "l": "amicoumacin A 2-phosphate + H2O => amicoumacin A + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050502", "l": "cis-zeatin O-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: cis-zeatin + UDP-D-glucose = O-beta-D-glucosyl-cis-zeatin + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32952", "l": "sucrose => trehalulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9689680", "l": "IFNG dimer binds IFNG inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48267", "l": "H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] <=> H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23518", "l": "(2R)-3-phosphoglycerate + ADP + H(+) => (R)-glycerate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804100", "l": "HMGB1 binds LPS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41769", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) => CMP + ganglioside GT1a (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19035", "l": "an N-acyl-D-mannosamine => an N-acyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65104", "l": "aculene D + L-prolyl-[peptidyl-carrier protein] = aculene B + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008932", "l": "lytic endotransglycosylase activity", "d": ["Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends."]}, {"i": "EC:4.2.2.n2", "l": "\"peptidoglycan lytic endotransglycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53536", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O = (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57881", "l": "3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose => 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708557", "l": "FBXL17 binds BACH1:MAFK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32453", "l": "all-trans-phytoene + 2 diphosphate => 2 (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41175", "l": "Co(I)-[dimethylamine-specific corrinoid protein] + dimethylamine + H(+) = methyl-Co(III)-[dimethylamine-specific corrinoid protein] + methylamine", "d": []}, {"i": "EC:2.1.1.249", "l": "\"[dimethylamine--corrinoid protein] Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681294", "l": "IL6R binds IL6R inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56741", "l": "globoside Gb3Cer + UDP-alpha-D-galactose => GalGb3Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17928", "l": "alpha-L-arabinopyanose + NAD(+) <=> H(+) + L-arabinono-1,4-lactone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.182", "l": "\"4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864577", "l": "TFAP2C translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44761", "l": "2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036237", "l": "acyl-glucuronidase activity", "d": ["Catalysis of the reaction: an acyl-glucuronoside + H2O = an alcohol + D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013159", "l": "CDC42 GEFs activate CDC42 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013284", "l": "NOTCH3-ligand complex is cleaved to produce NEXT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65174", "l": "(3Z,5E)-dodecadienoate + CoA + H(+) => (3Z,5E)-dodecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14793", "l": "2-hydroxyadipate + NAD(+) = 2-oxoadipate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.172", "l": "\"2-oxoadipate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13452", "l": "2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73214", "l": "H(+)(in) + sucrose(out) <=> H(+)(out) + sucrose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57957", "l": "dimethyl sulfoxide + H(+) + NADH + O2 => dimethyl sulfone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41241", "l": "N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine => N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23665", "l": "A + a (2R)-2-hydroxycarboxylate => a 2-oxocarboxylate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350598", "l": "Arginine<=>Agmatine+CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21387", "l": "L-phenylalanine <=> (E)-cinnamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015518", "l": "arabinose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: arabinose(out) + H+(out) = arabinose(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944225", "l": "Association of procollagen type XVII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39307", "l": "(2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH = (11Z,14Z)-eicosadienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296477", "l": "Defective AMN does not transport GIF:Cbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45451", "l": "H2O + N-(dodecanoyl)-sphinganine <=> dodecanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32595", "l": "7-isopropyl-4-methyloxepan-2-one + H2O = 6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65952", "l": "2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102791", "l": "sulfuretin synthase activity", "d": ["Catalysis of the reaction: butein 4'-beta-D-glucoside + O2 + 2 H+ = sulfuretin 6-glucoside + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41948", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.103", "l": "\"[amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17959", "l": "H2O + propynoate => 3-oxopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799199", "l": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12761", "l": "precorrin-3B + S-adenosyl-L-methionine = 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.131", "l": "\"precorrin-3B C(17)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60509", "l": "a guanosine in mRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57921", "l": "4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) => H(+) + L-asparaginyl-tRNA(Asn) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199298", "l": "AKT phosphorylates CREB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17825", "l": "ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693478", "l": "HTR1A binds HTR1A agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70982", "l": "Fumarate + H2O <=> (S)-Malate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16922", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13807", "l": "a 3-oxo-Delta(4)-steroid + AH2 => A + a 3-oxo-5alpha-steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38049", "l": "a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35423", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP", "d": []}, {"i": "EC:2.4.1.298", "l": "\"anthocyanidin 3-O-glucoside 5-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52854", "l": "6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin] => a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50867", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17807", "l": "adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine => H2O + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27664", "l": "2-oxoglutarate + H2O2 => (S)-2-hydroxyglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47794", "l": "5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912391", "l": "NICD1 is phosphorylated by CDK8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41243", "l": "N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine = N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696268", "l": "RND3 binds effectors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29208", "l": "a menaquinol(in) + dimethyl sulfoxide(out) => a menaquinone(in) + dimethyl sulfide(out) + H2O(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012651", "l": "p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44342", "l": "AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate => (S)-2,3-diaminopropanoate + ATP + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161282", "l": "Elastic fibres bind associated proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17144", "l": "glycine + oxaloacetate <=> glyoxylate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55680", "l": "(2S)-2-amino-4-deoxychorismate = anthranilate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57144", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322429", "l": "XIAP monoubiquinates TLE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016720", "l": "delta12-fatty acid dehydrogenase activity", "d": ["Catalysis of the reaction: AH(2) + linoleate + O2 = A + crepenynate + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757097", "l": "SARS-CoV-2 N binds NLRP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749609", "l": "BCHE hydrolyzes ASA- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953111", "l": "E2F6 binds TFDP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73714", "l": "ATP(in) + UTP(out) <=> ATP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57247", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP <=> dGTP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874718", "l": "TTPA binds alpha-TOH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24142", "l": "2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45948", "l": "acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811427", "l": "COPI vesicle uncoating at the ER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863463", "l": "STON2 binds SYT proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.46", "l": "\"gentamicin 2''-nucleotidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56069", "l": "an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507875", "l": "Aquaporins passively transport urea into cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17906", "l": "(R)-glycerate + NAD(+) => 3-hydroxypyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111264", "l": "Addition of nucleotides between position +11 and +30 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170116", "l": "Myt-1 mediated phosphorylation of Cyclin A:Cdc2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811427", "l": "COPI vesicle uncoating at the ER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61831", "l": "stigmasterol + UDP-alpha-D-glucose <=> H(+) + stigmasteryl 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0048185", "l": "activin binding", "d": ["Binding to activin, a dimer of inhibin-beta subunits."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008432", "l": "JUN kinase binding", "d": ["Binding to JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1449687", "l": "Corticosteroids bind to CBG in blood (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23764", "l": "diphosphate + L-serine = H(+) + O-phospho-L-serine + phosphate", "d": []}, {"i": "EC:2.7.1.80", "l": "\"diphosphate--serine phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015565", "l": "threonine efflux transmembrane transporter activity", "d": ["Enables the transfer of threonine from the inside of the cell to the outside of the cell across a membrane."]}, {"i": "RHEA:35019", "l": "L-threonine(in) = L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61324", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59534", "l": "(S)-codamine + H(+) + S-adenosyl-L-homocysteine => (S)-reticuline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24426", "l": "glutathione disulfide + L-ascorbate => 2 glutathione + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64083", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O <=> 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.1", "l": "\"P-type phospholipid transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782943", "l": "UV-DDB ubiquitinates XPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052855", "l": "ADP-dependent NAD(P)H-hydrate dehydratase activity", "d": ["Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ADP = AMP + 3 H+ + NADH + phosphate."]}, {"i": "EC:4.2.1.136", "l": "\"ADP-dependent NAD(P)H-hydrate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.15", "l": "\"grixazone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327733", "l": "FN1 binds Collagen types I-V, VII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14687", "l": "AH2 + an aldehyde => A + a primary alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70496", "l": "D-glucose(out) + 2 Na(+)(out) => D-glucose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43053", "l": "3-(methylsulfanyl)propanoate + ATP + CoA => 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56684", "l": "dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine", "d": []}, {"i": "EC:1.14.19.61", "l": "\"dihydrorhizobitoxine desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16673", "l": "3-phosphonopyruvate + H2O = H(+) + phosphate + pyruvate", "d": []}, {"i": "EC:3.11.1.3", "l": "\"phosphonopyruvate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430190", "l": "p-SLP-76 binds NCK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140619", "l": "DNA strand exchange activator activity", "d": ["Binds to and increases a DNA strand exchange activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22403", "l": "androstan-3alpha,17beta-diol + NAD(+) <=> 17beta-hydroxyandrostanone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691004", "l": "XPC binds RAD23 and CETN2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76062", "l": "heliamine + S-adenosyl-L-methionine <=> H(+) + N-methylheliamine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008559", "l": "ABC-type xenobiotic transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013023", "l": "RHOB GEFs activate RHOB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50820", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = H(+) + NADPH + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67251", "l": "(E)-4-hydroxynon-2-enal + H2O + NAD(+) <=> (E)-4-hydroxynon-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55667", "l": "2 AH2 + echinenone + 2 O2 <=> 2 A + canthaxanthin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34137", "l": "Delta(9)-tetrahydrocannabinolate + H2O2 => cannabigerolate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58888", "l": "4-aminobenzoate + AH2 + 2 O2 = 4-nitrobenzoate + A + 2 H2O", "d": []}, {"i": "EC:1.14.99.68", "l": "\"4-aminobenzoate N-oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41700", "l": "1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3159253", "l": "MMAB adenosylates cob(I)alamin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050107", "l": "monoterpenol O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + a monoterpenol = CoA + a monoterpenol acetate ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35705", "l": "(2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+) => 1'-hydroxyversicolorone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53735", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate <=> 2-hydroxy-7,8-dihydropteroate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27561", "l": "all-trans-hexaprenyl diphosphate + 3 diphosphate => (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41881", "l": "(2E)-dodecenoyl-[ACP] + H(+) + NADPH => dodecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24359", "l": "a 1-acyl-sn-glycero-3-phosphocholine <=> a 2-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51159", "l": "ATP + L-glutamate + tRNA(Glu) <=> AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.6", "l": "\"aminopeptidase B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.103", "l": "\"phosphoethanolamine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47204", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25469", "l": "(2E,6E)-farnesyl diphosphate => beta-himachalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71506", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(in) <=> a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050204", "l": "oxalomalate lyase activity", "d": ["Catalysis of the reaction: 3-oxalomalate = glyoxylate + oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32539", "l": "(2E)-geranyl diphosphate = (+)-car-3-ene + diphosphate", "d": []}, {"i": "EC:4.2.3.107", "l": "\"(+)-car-3-ene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5627072", "l": "RHOQ binds GOPC:CFTR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696960", "l": "USP49 deubiquitinates H2B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31986", "l": "abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635912", "l": "Expression of TRIB3 in response to stress (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32039", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = AMP + ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662603", "l": "MT1B binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-481009", "l": "Exocytosis of platelet dense granule content (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867047", "l": "PTPN3 dephosphorylates EPS15 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42238", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69694", "l": "ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine <=> ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701507", "l": "PTPN6 dephosphorylates JAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756136", "l": "PON1,3 hydrolyse 2-OH-ATVL to 2-OH-ATV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047135", "l": "bis-gamma-glutamylcystine reductase activity", "d": ["Catalysis of the reaction: 2 L-gamma-glutamyl-L-cysteine + NADP+ = bis-gamma-glutamylcystine + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36381", "l": "4alpha-methylzymosterol + NADP(+) => 3-dehydro-4alpha-methylzymosterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352872", "l": "fructose 6-phosphate <=> glucose 6-phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9659611", "l": "ANO1 inhibitors bind ANO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59157", "l": "ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] => AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39609", "l": "(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+) => (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2559439", "l": "CD14:LPS binds CR3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56795", "l": "2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67175", "l": "O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] <=> formate + 2 H(+) + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9821486", "l": "HCFC1 binds SET1A complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50362", "l": "benzoyl cyanide + H2O2 => (R)-mandelonitrile + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47784", "l": "cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193761", "l": "25(R) TetraHCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67465", "l": "H2O + propanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28297", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-(E)-beta-caryophyllene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23598", "l": "3 H(+) + 2 NADH + UDP-alpha-D-glucuronate => H2O + 2 NAD(+) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22253", "l": "globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => globoside Gb4Cer (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032428", "l": "beta-N-acetylgalactosaminidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757256", "l": "MCM3 binds MCM5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209960", "l": "Diiodinated tyrosine can be deiodinated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28086", "l": "2 H2O2 + Reactive Blue 5 = 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate", "d": []}, {"i": "EC:1.11.1.19", "l": "\"dye decolorizing peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190260", "l": "FGFR2b binds to FGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034804", "l": "benzo(a)pyrene 11,12-epoxidase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-11,12-epoxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50501", "l": "acetyl-CoA + N-terminal L-alanyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13287", "l": "ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate => ATP + L-cysteine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70484", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in single-stranded DNA + H2O + O2 => a 2'-deoxyguanosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57797", "l": "4-nitrotoluene + NADH + O2 => 4-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696457", "l": "BDH2 dehydrogenates 3HBA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29285", "l": "L-alanine(out) + Na(+)(out) => L-alanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40606", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52027", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 <=> 18S-resolvin E2 + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48902", "l": "3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786789", "l": "FLT3LG dimer binds FLT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050580", "l": "2,5-didehydrogluconate reductase activity", "d": ["Catalysis of the reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209944", "l": "25(OH)D binds GC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664850", "l": "ATM binds PEX5 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59712", "l": "D-maltotetraono-1,5-lactone + H2O = D-maltotetraonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22361", "l": "D-glutamate => 5-oxo-D-proline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73686", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphing-4-enine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41890", "l": "(3R)-hydroxytetradecanoyl-[ACP] + NADP(+) => 3-oxotetradecanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48323", "l": "ganglioside GA1 + GDP-beta-L-fucose <=> ganglioside Fuc-GA1 + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57655", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 <=> CMP + ganglioside GM1alpha + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74228", "l": "H2O + L-threonyl-tRNA(Ile) => L-threonine + tRNA(Ile)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39219", "l": "3-oxooctacosanyol-CoA + H(+) + NADPH = (3R)-hydroxyoctacosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623558", "l": "Defective SLC11A2 does not cotransport Fe2+, H+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804425", "l": "TP53 binds POU4F2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018814", "l": "phenylacetaldoxime dehydratase activity", "d": ["Catalysis of the reaction: (trans)-phenylacetaldoxime = H2O + phenylacetonitrile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32684", "l": "5-hydroxymethylfurfural + 2 H2O + 3 O2 => 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190261", "l": "FGFR3c binds to FGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34954", "l": "3-hydroxypropanoate(out) <=> 3-hydroxypropanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36285", "l": "7-methylxanthine + formaldehyde + H2O + NADP(+) => 1,7-dimethylxanthine + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033094", "l": "butane-1,4-diamine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912416", "l": "NOTCH1 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68728", "l": "26-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxy-lanosta-8, 24-dien-26-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57477", "l": "dodecanoate + H2O2 => 2-hydroxydodecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187506", "l": "Translocation of p27 to the nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008673", "l": "2-dehydro-3-deoxygluconokinase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450494", "l": "HuR binds mRNAs in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66555", "l": "L-glutaminyl-[protein] + serotonin <=> 5-serotonyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0061840", "l": "high-affinity ferrous iron transmembrane transporter activity", "d": ["Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1671687", "l": "PRLR activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938108", "l": "SERPINB13 binds cathepsin L (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43455", "l": "2 H(+) + hexanoyl-CoA + 2 malonyl-CoA <=> 4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106347", "l": "U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity", "d": ["Catalysis of the reaction: a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+."]}, {"i": "RHEA:62672", "l": "a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47402", "l": "(7Z)-hexadecenoyl-CoA + acetyl-CoA => 3-oxo-(9Z-octadecenoyl)-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140382", "l": "tryptamine 4-monooxygenase activity", "d": ["Catalysis of the reaction: tryptamine + reduced acceptor + O2 <=> 4-hydroxytryptamine + acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63230", "l": "9-O-adenylylspectinomycin + diphosphate => ATP + spectinomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033292", "l": "NTRK2 and CDK5 promote activation of RAC1 by TIAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60451", "l": "an S-substituted glutathione + H2O <=> glycine + S-substituted gamma-glutamyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.-", "l": "\"Acid--ammonia (or amine) ligases (amide synthases)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73663", "l": "(E,E)-piperoyl-CoA + pyrrolidine = CoA + H(+) + piperyline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24707", "l": "(6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose => (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19773", "l": "NADP(+) + sn-glycerol 3-phosphate = D-glyceraldehyde 3-phosphate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.177", "l": "\"glycerol-3-phosphate 1-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671772", "l": "p-T38-PPP1R14A binds MLCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683831", "l": "CCDC59 binds TTF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11739", "l": "2-exo-hydroxy-1,8-cineole + NAD(+) <=> 6-oxocineole + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102808", "l": "pelargonidin 3-O-glucoside 2''-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + pelargonidin 3-O-beta-D-glucoside <=> H+ + pelargonidin 3-O-sophoroside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41365", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099580", "l": "monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential", "d": ["Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31342", "l": "acetate + ATP + holo-[ACP] <=> acetyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170159", "l": "Translocation of Cdc25 to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34682", "l": "ATP + methylphosphonate <=> adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687465", "l": "HSV1 RIR1 binds RIPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10358", "l": "5beta-androstane-3,17-dione + H(+) + NADH => 3alpha-hydroxy-5beta-androstan-17-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724290", "l": "GNRHR2 binds GNRH1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373746", "l": "SEMA4D interacts with CD45 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036033", "l": "mediator complex binding", "d": ["Binding to a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30787", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013435", "l": "RHOD auto-activates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.79", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008995", "l": "ribonuclease E activity", "d": ["Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805638", "l": "KAT6A acetylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63960", "l": "abscisate(out) + ATP + H2O = abscisate(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19653", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) = CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65948", "l": "a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2 = A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73654", "l": "CTP(out) <=> CTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48696", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58472", "l": "2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647977", "l": "ICMT methylates S-Farn RAS proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201637", "l": "Caspase-mediated cleavage of plectin-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944215", "l": "Association of procollagen type XX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800380", "l": "PTPRD binds IL1RAP-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59064", "l": "demethylluteothin + S-adenosyl-L-methionine = luteothin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52553", "l": "3-dehydro-L-erythronate + ATP => 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56478", "l": "(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10850", "l": "ADP + an [alpha-factor](out) + H(+) + phosphate => an [alpha-factor](in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19263", "l": "ADP + H(+) + heme b(out) + phosphate => ATP + H2O + heme b(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163551", "l": "triacylglycerol + H2O -> diacylglycerol + fatty acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102717", "l": "DIBOA-glucoside oxygenase activity", "d": ["Catalysis of the reaction: DIBOA-beta-D-glucoside + O2 + 2-oxoglutarate <=> TRIBOA-beta-D-glucoside + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50004", "l": "H(+) + NADPH + O2 + tetracycline = 11a-hydroxytetracycline + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.231", "l": "\"tetracycline 11a-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72689", "l": "all-trans-retinol(in) => all-trans-retinol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59450", "l": "dodecanal + H(+) + NADPH => dodecan-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48813", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14051", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol => O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015501", "l": "glutamate:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in)."]}, {"i": "RHEA:29031", "l": "L-glutamate(in) + 2 Na(+)(in) = L-glutamate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296043", "l": "Activation of HCN channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13211", "l": "AH2 + 4 H(+) + 3 sulfite => A + 3 H2O + trithionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38454", "l": "hydrogen sulfide + NADP(+) + n sulfur <=> NADPH + (n+1) sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16449", "l": "acetyl-CoA + kanamycin B = CoA + H(+) + N(6')-acetylkanamycin B", "d": []}, {"i": "EC:2.3.1.82", "l": "\"aminoglycoside 6'-N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28079", "l": "2-hydroxyethylphosphonate + NAD(+) => H(+) + NADH + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193700", "l": "p75NTR ICD signals to NF-kB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56995", "l": "6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) <=> (+)-costunolide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50938", "l": "acetoacetyl-CoA + L-glutamate => (3S)-3-aminobutanoyl-CoA + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044535", "l": "very-long-chain fatty acyl-CoA oxidase activity", "d": ["Catalysis of the reaction: very-long-chain fatty acyl-CoA (C22 - C24) + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47808", "l": "epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050479", "l": "glyceryl-ether monooxygenase activity", "d": ["Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43692", "l": "ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] = AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]", "d": []}, {"i": "EC:2.7.11.32", "l": "\"[pyruvate, phosphate dikinase] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6799350", "l": "Exocytosis of specific granule membrane proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62293", "l": "(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250979", "l": "botG:SYT1:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76416", "l": "Benzene is hydroxylated to phenol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33442", "l": "glyoxal + H2O + O2 <=> glyoxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55210", "l": "(2R)-hydroxyhexadecanal + phosphoethanolamine => (4R)-hydroxysphinganine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37791", "l": "aclacinomycin A + O2 = aclacinomycin Y + H2O2", "d": []}, {"i": "EC:1.3.3.14", "l": "\"aclacinomycin-A oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48616", "l": "H2O + leukotriene D4 = glycine + leukotriene E4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44523", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018513", "l": "dibenzothiophene dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD+ = 1,2-dihydroxydibenzothiophene + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034567", "l": "chromate reductase activity", "d": ["Catalysis of the reaction: chromate = chromium (III)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950389", "l": "Expression of Stress-70 protein, mitochondrial (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67891", "l": "3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine <=> 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0051019", "l": "mitogen-activated protein kinase binding", "d": ["Binding to a mitogen-activated protein kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112385", "l": "Addition of nucleotides leads to transcript elongation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74409", "l": "2 (S)-lactate(out) + thromboxane B2(in) => 2 (S)-lactate(in) + thromboxane B2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17820", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944223", "l": "Association of procollagen type V (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173739", "l": "Spontaneous hydrolysis of C3 thioester (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48424", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0031267", "l": "small GTPase binding", "d": ["Binding to a small monomeric GTPase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180732", "l": "Translocation of Rev:importin-beta:B23 to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912386", "l": "Ubiquitination of NOTCH1 by ITCH in the absence of ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106436", "l": "glutathione-dependent sulfide quinone oxidoreductase activity", "d": ["Catalysis of the reaction: a quinone + glutathione + H(+) + hydrogen sulfide <=> a quinol + S-sulfanylglutathione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704248", "l": "CHRM4 binds CHRM4 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19980", "l": "3'-phosphoadenylyl sulfate + L-tyrosine methyl ester <=> adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49360", "l": "2',2'-dihydroxy-2-oxospirilloxanthin = 2,2'-dioxospirilloxanthin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9698844", "l": "MLKL binds HSP90:CDC37 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24592", "l": "CTP + H(+) + phosphoethanolamine = CDP-ethanolamine + diphosphate", "d": []}, {"i": "EC:2.7.7.14", "l": "\"ethanolamine-phosphate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15289", "l": "[(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose = [(1->4)-beta-D-xylan](n+1) + H(+) + UDP", "d": []}, {"i": "EC:2.4.2.24", "l": "\"1,4-beta-D-xylan synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67526", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine => 4,8-dimethylnonanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010298", "l": "dihydrocamalexic acid decarboxylase activity", "d": ["Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2 + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299338", "l": "Activation of TRESK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11139", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917730", "l": "Cargo Recognition And Sorting (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388831", "l": "Phosphorylation of CD28 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805205", "l": "GPR35 binds kynurenic acid (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48709", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47078", "l": "17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+) => 17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45243", "l": "a (3E,5Z)-dienoyl-CoA <=> a (2E,4E)-(5,6-saturated)-dienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74320", "l": "O-acetyl-(R)-carnitine(in) => O-acetyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35831", "l": "2-oxoglutarate + kanamycin B + O2 = 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate", "d": []}, {"i": "EC:1.14.11.37", "l": "\"kanamycin B dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12816", "l": "L-glutamate <=> D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74980", "l": "(3R)-3-isocyanylbutanoate + ATP + H(+) => (3R)-3-isocyanylbutanoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042557", "l": "eukaryotic elongation factor-2 kinase activator activity", "d": ["Binds to and increases the activity of the enzyme eukaryotic elongation factor-2 kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204863", "l": "Interaction of Tie2 with Ang2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65421", "l": "GMP(in) + NAD(+)(out) => GMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090447", "l": "glycerol-3-phosphate 2-O-acyltransferase activity", "d": ["Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = CoA + a 2-acyl-sn-glycerol 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52454", "l": "16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha-hydroxyestrone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625424", "l": "The retrograde IFT train dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109701", "l": "PDPK1 binds PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757686", "l": "SERPINA6 binds PREDL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19523", "l": "acetyl phosphate + CoA => acetyl-CoA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38147", "l": "carbon disulfide + H2O = carbonyl sulfide + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53287", "l": "NAD(+) + scyllo-inosose <=> 3-dehydro-scyllo-inosose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707523", "l": "Hemes bind to BACH1:MAFK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74776", "l": "kaempferide + S-adenosyl-L-methionine => 7,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.25", "l": "\"beta-peptidyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424485", "l": "Release of p-PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9010815", "l": "SLITs bind keratan sulfate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876789", "l": "CARNMT1 methylates CARN to Anserine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13882", "l": "a quinone + an aldehyde + H2O => a carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2317332", "l": "PIP3 recruits AKT to the membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28620", "l": "2-hydroxy-2-methylbutanenitrile + H2O + NADP(+) => 2-methylbutyronitrile + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74559", "l": "aldosterone = aldosterone hemiacetal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28863", "l": "H(+)(out) + lactose(in) = H(+)(in) + lactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67802", "l": "2 CO2 + 2 formaldehyde + L-lysyl(27)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22459", "l": "creatine + H2O <=> sarcosine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60291", "l": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74769", "l": "3,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + syringetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786421", "l": "CHIA hydrolyses chitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944247", "l": "Association of procollagen type VI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64280", "l": "(S)-1-phenylethylamine + pyruvate = acetophenone + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61338", "l": "ADP + H(+) + phosphate + protoporphyrin IX(out) => ATP + H2O + protoporphyrin IX(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140211", "l": "folic acid:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: folic acid(out) + H+(out) = folic acid(in) + H+(in). The main folic acid symporter is the Proton-Coupled Folate Transporter (PCFT/SLC46A1), which has similar affinity for transport of reduced folates (5-methyl THF, 5-formyl THF) and folic acid."]}, {"i": "TCDB:2.A.1.50.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985943", "l": "p-Y701-STAT1 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17885", "l": "acetaldehyde = acetylene + H2O", "d": []}, {"i": "EC:4.2.1.112", "l": "\"acetylene hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56799", "l": "ATP + cob(I)alamin-[corrinoid adenosyltransferase] <=> adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694575", "l": "Nucleoprotein translocates to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685162", "l": "SARS-CoV-1 M protein interacts with TRAF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39561", "l": "(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649735", "l": "Intrinsic nucleotide exchange on RAS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180627", "l": "Interaction of Vpr with importin alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37978", "l": "H(+) + homogentisate + phytyl diphosphate <=> 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29785", "l": "ADP + H(+) + L-cysteine(out) + phosphate => ATP + H2O + L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51526", "l": "magnoflorine + S-adenosyl-L-homocysteine => (S)-corytuberine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50981", "l": "prostaglandin E1(out) => prostaglandin E1(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31566", "l": "H2O + leukotriene C4 <=> L-glutamate + leukotriene D4", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046989", "l": "galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity", "d": ["Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids."]}]}
{"type": "biolink:MolecularActivity", "ic": "78.179166783752436", "identifiers": [{"i": "GO:0016895", "l": "DNA exonuclease activity, producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52589", "l": "choloyl-CoA + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5444523", "l": "Formation of MSH1:PMS2 Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748991", "l": "XDH oxidises 6MP to 6TU (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196753", "l": "2xPPCS ligates PPanK with Cys (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43269", "l": "ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GM2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190261", "l": "FGFR3c binds to FGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11686", "l": "dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine => methylarsonous acid + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61021", "l": "acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA => 5'-deoxyadenosine + 5-(carboxymethyl)uridine(34) in tRNA + CoA + 2 H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166286", "l": "Multiple IRAK1 autophosphorylation steps (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817983", "l": "CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106054", "l": "tRNA U34 sulfurtransferase activity", "d": ["Catalysis of the reaction: uridine34 in tRNA + a [TusE sulfur carrier protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 2-thiouridine34 in tRNA + a [TusE sulfur carrier protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65633", "l": "a sphingoid base + tetracosanoyl-CoA => an N-tetracosanoyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42651", "l": "(2,5-ethylene furandicarboxylate)(n) + 2 H2O <=> (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989770", "l": "Expression of PLIN2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43939", "l": "androst-5-ene-3,17-dione <=> androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-981539", "l": "C3b binds to cell surface (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26470", "l": "(E)-feruloyl-CoA + 16-hydroxyhexadecanoate = 16-feruloyloxyhexadecanoate + CoA", "d": []}, {"i": "EC:2.3.1.188", "l": "\"omega-hydroxypalmitate O-feruloyl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46930", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64507", "l": "AH2 + H(+) + 3 malonyl-CoA + propanoyl-CoA + 2 S-adenosyl-L-methionine <=> 2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33016", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 => [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692315", "l": "OX40L binds OX40 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694441", "l": "CSNK1D phosphorylates SEC23 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75608", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => plasmodiophorol B", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033988", "l": "bile-acid 7alpha-dehydratase activity", "d": ["Catalysis of the reaction: 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69685", "l": "CHEK2 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53863", "l": "7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+) <=> dehydrocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21580", "l": "(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2", "d": []}, {"i": "EC:4.1.1.5", "l": "\"acetolactate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13076", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O <=> guanosine 3',5'-bis(diphosphate) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24363", "l": "2 H(+) + siroheme <=> Fe(2+) + sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848774", "l": "PTK6 binds DOK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849085", "l": "ARHGAP35 binds RHOA:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58296", "l": "25-substituted-cholesterol + beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine = 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51310", "l": "H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+) => H(+) + L-methionyl-[F-actin] + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53550", "l": "Delta(12)-prostaglandin J2 => prostaglandin J2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008574", "l": "plus-end-directed microtubule motor activity", "d": ["A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52732", "l": "3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate = adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16399", "l": "D-glucose + D-glucose 1,6-bisphosphate => 2 D-glucopyranose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16075", "l": "CO2 + dialkyl ketone + L-alanine => 2,2-dialkylglycine + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61313", "l": "germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30494", "l": "L-valine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58933", "l": "4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH => 5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15274", "l": "2-oxoglutarate + L-dopa => 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951966", "l": "EP300 acetylates RUNX3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690873", "l": "ACO1 binds 4Fe-4S (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.16", "l": "\"membrane Pro-Xaa carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876484", "l": "NPC2 transfers CHOL to NPC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604732", "l": "Autocatalytic activation of proMMP13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0160012", "l": "NAD-dependent histone decrotonylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[histone] + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2426566", "l": "Interaction of DAP12 and CLM7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50086", "l": "ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out) => ATP + H2O + taurolithocholate 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951951", "l": "RUNX3 binds EP300 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35635", "l": "an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose = an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.296", "l": "\"anthocyanidin 3-O-coumaroylrutinoside 5-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9760402", "l": "ILF3 binds HOXC8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112604", "l": "Phosphorylated STATs are released (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195304", "l": "Association of beta-catenin with the destruction complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20093", "l": "an anthocyanidin + H(+) + UDP-alpha-D-glucose = an anthocyanidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.87", "l": "\"aralkylamine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617867", "l": "HOXB4 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34351", "l": "(2E)-geranial + H2O + NAD(+) = geranate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.86", "l": "\"geranial dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938121", "l": "SERPINB13 binds CTSK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196017", "l": "Dynamin is recruited to the gap junction plaque (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14588", "l": "gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0030699", "l": "glycine reductase activity", "d": ["Catalysis of the reaction: acetyl phosphate + H2O + NH4 + thioredoxin disulfide = glycine + H+ + phosphate + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33758", "l": "H2O + N-hexadecanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247922", "l": "GGCT transforms gGluCys to OPRO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417843", "l": "P2Y13 binds ADP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42483", "l": "2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15254", "l": "cis-aconitate + H(+) => CO2 + itaconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23268", "l": "guanidinoacetate + H2O = glycine + urea", "d": []}, {"i": "EC:3.5.3.2", "l": "\"guanidinoacetase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190258", "l": "FGFR2c binds to FGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73971", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102190", "l": "4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) <=> 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24788", "l": "3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-398184", "l": "LARG activation by G alpha 12/13 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73729", "l": "Formation of SL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2059926", "l": "NPHP4 protein binds LATS proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13671", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + CO2 => 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617182", "l": "PRKACA phosphorylates PLN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111264", "l": "Addition of nucleotides between position +11 and +30 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58161", "l": "ent-copalyl diphosphate => diphosphate + dolabradiene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0016454", "l": "C-palmitoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75424", "l": "(R,S)-butane-2,3-diol + NAD(+) => (R)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983147", "l": "Release of E3 from polyubiquitinated substrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019112", "l": "phenanthrol glycosyltransferase activity", "d": ["Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140065", "l": "peptide butyryltransferase activity", "d": ["Catalysis of the reaction: butyryl-CoA + lysine in peptide = CoA + N-butyryl-lysine-peptide."]}, {"i": "RHEA:53912", "l": "butanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5444516", "l": "Formation of MSH2:MSH6 Complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70174", "l": "H(+)(in) + pemetrexed(in) <=> H(+)(out) + pemetrexed(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733292", "l": "AMY1-3 bind pramlintide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432172", "l": "Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73348", "l": "beta-alanyl-[peptidyl-carrier protein] + tryptamine => beta-alanyl-tryptamine + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50254", "l": "a 3-oxoacyl-CoA + CO2 + CoA => an acyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46890", "l": "3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2 => 3-deoxy-alpha-D-manno-oct-2-ulosonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034042", "l": "5-formyluracil DNA N-glycosylase activity", "d": ["Catalysis of the removal of 5-formyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-265177", "l": "Exocyst complex formation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18561", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.70", "l": "\"Delta(14)-sterol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54894", "l": "[LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide => [LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199935", "l": "MSK1 activates CREB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030945", "l": "protein tyrosine phosphatase activity, via thiol-phosphate intermediate", "d": ["The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28265", "l": "3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose <=> 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534206", "l": "E-cadherin degradation by PS1:NCSTN (Gamma-secretase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55626", "l": "3-methylcytosine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+) => an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750942", "l": "USP14 deubiquitinates NLRC5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11033", "l": "(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate => 3-chloro-cis,cis-muconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449077", "l": "Interleukin-16 is secreted (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66997", "l": "2-methylpentanoate + ATP + CoA => 2-methylpentanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24862", "l": "pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose => H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73835", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.156", "l": "\"geranylfarnesylglycerol-phosphate geranylfarnesyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53220", "l": "16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32993", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071074", "l": "eukaryotic initiation factor eIF2 binding", "d": ["Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10039", "l": "4-hydroxy-3-methoxy-benzenemethanol + O2 <=> H2O2 + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164377", "l": "Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984821", "l": "Kinesin-12 is a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64165", "l": "2-methyl-L-serine => formaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41499", "l": "1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52016", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.58", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52863", "l": "a short-chain fatty acid + ATP + CoA <=> a short-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49976", "l": "butanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60569", "l": "N-acetyl-L-tryptophan => N-acetyl-D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617828", "l": "TRIP11:IFT20 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649856", "l": "Oxidative damage to the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176298", "l": "Activation of claspin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53098", "l": "4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine => 4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33487", "l": "(4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA = CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74199", "l": "aspulvinone E + O2 = (2Z)-2-[(3,4-dioxocyclohexa-1,5-dien-1-yl)methylidene]-4-(4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-olate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508513", "l": "PTK2B binds JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58773", "l": "1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264865", "l": "Caspase-mediated cleavage of Lamin A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209536", "l": "IkB is ubiquitinated and degraded (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628756", "l": "NEIL1 G83D does not cleave FapyA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29072", "l": "a ubiquinone + formate + H(+) => a ubiquinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102539", "l": "UDP-N-acetyl-alpha-D-fucosamine dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-fucosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170978", "l": "p-FRS2:CRKL binds C3G (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1008200", "l": "NFE2 binds the beta globin locus control region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19561", "l": "androst-4-ene-3,17-dione + H(+) + NADPH + O2 = H2O + NADP(+) + testololactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43810", "l": "1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71137", "l": "H(+)(out) + L-histidine(in) + Na(+)(in) => H(+)(in) + L-histidine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032794", "l": "GTPase activating protein binding", "d": ["Binding to a GTPase activating protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38697", "l": "a cardiolipin(out) => a cardiolipin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58324", "l": "beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669023", "l": "TWEAK binds FN14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41752", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937869", "l": "RUNX2:CBFB:p-Y-YAP1 binds the BGLAP gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5246478", "l": "APOM binds retinoids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26565", "l": "2-succinylbenzoyl-CoA + H(+) <=> 1,4-dihydroxy-2-naphthoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64239", "l": "atrochrysone carboxyl-[ACP] + H2O <=> atrochrysone carboxylate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362437", "l": "C-terminal Hh fragments are bound by lectins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63536", "l": "bradykinin(1-8) + H2O = bradykinin(1-7) + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.165", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691167", "l": "CUL1, SKP1, FBXL5 bind (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218847", "l": "PAK2 binds NCK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28858", "l": "H(+)(in) + melibiose(in) <=> H(+)(out) + melibiose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65827", "l": "dec-9-enoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> dec-9-ynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46041", "l": "2'-deoxycytidine + ATP => ADP + dCMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047156", "l": "acetoin-ribose-5-phosphate transaldolase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + acetoin = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047835", "l": "D-tryptophan N-acetyltransferase activity", "d": ["Catalysis of the reaction: D-tryptophan + acetyl-CoA = N-acetyl-D-tryptophan + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55250", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672961", "l": "PP2A dephosphorylates inactive RAFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69127", "l": "Formation of the Flap Intermediate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54764", "l": "5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine = [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395340", "l": "Formation of hydroxyallysine by LOX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36965", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA => (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66572", "l": "2-naphthol + 3'-phosphoadenylyl sulfate = 2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019142", "l": "2-hydroxyglutarate synthase activity", "d": ["Catalysis of the reaction: glyoxylate + H2O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22222", "l": "diphosphate + ent-kaur-16-ene => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867097", "l": "CD99 binds CD99L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63974", "l": "AH2 + pyriculol => A + dihydropyriculol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72005", "l": "(S)-lactate(out) + urate(in) => (S)-lactate(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28720", "l": "adenine(in) + H(+)(in) => adenine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33938", "l": "2 N(omega)-hydroxy-L-arginine + NADH + 2 O2 <=> H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50669", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54850", "l": "H2O + NADP(+) + propyl propanoate => H(+) + hexan-3-one + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928641", "l": "PAK binds RAC and bPIX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68950", "l": "H(+) + S-adenosyl-L-homocysteine + scopoletin => esculetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.4", "l": "\"glucose oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944225", "l": "Association of procollagen type XVII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55928", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55982", "l": "an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+) => a 1,2-saturated acyl-CoA + an acyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45048", "l": "acetamide + H2O = acetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60681", "l": "(+)-artemisinic aldehyde + H2O + NADP(+) => (+)-artemisinate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47092", "l": "(S)-2,3-dihydrodipicolinate + NADP(+) = dipicolinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72316", "l": "glutathione(in) + leukotriene C4(out) => glutathione(out) + leukotriene C4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605057", "l": "ABCA1 gene transcription regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0035939", "l": "microsatellite binding", "d": ["Binding to a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38691", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694428", "l": "LMAN family proteins bind glycosylated cargo (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72939", "l": "2 Na(+)(out) + propanoate(out) = 2 Na(+)(in) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27730", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) = beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45365", "l": "H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine => (11Z)-eicosenoate + (4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876240", "l": "CBL binds InlB-activated MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24569", "l": "a 6-phospho-beta-D-galactoside + H2O => an alcohol + D-galactose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70561", "l": "L-threonyl-[protein] + N-acetyl-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60092", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) = 3-dehydro-4alpha-methylzymosterol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37126", "l": "sphing-4-enine + tetracosenoyl-CoA <=> CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173636", "l": "Formation of classic pathway C5 convertase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.362525179576039", "identifiers": [{"i": "GO:0030533", "l": "triplet codon-amino acid adaptor activity", "d": ["The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30498", "l": "N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72372", "l": "dehydroepiandrosterone 3-sulfate(out) + succinate(in) => dehydroepiandrosterone 3-sulfate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876484", "l": "NPC2 transfers CHOL to NPC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67247", "l": "3-deoxyglucosone + H2O + NAD(+) <=> 2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218836", "l": "PTK2beta binds alphaVbeta3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031724", "l": "CXCR5 chemokine receptor binding", "d": ["Binding to a CXCR5 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61540", "l": "ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46391", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047173", "l": "phosphatidylcholine-retinol O-acyltransferase activity", "d": ["Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205289", "l": "Autophosphorylation of KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047924", "l": "geraniol dehydrogenase activity", "d": ["Catalysis of the reaction: geraniol + NADP+ = geranial + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69462", "l": "[thioredoxin]-disulfide + 3 glutathione + H(+) + methylarsonous acid + S-adenosyl-L-homocysteine => [thioredoxin]-dithiol + arsenic triglutathione + 2 H2O + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102466", "l": "beta-carotene 2,2'-beta-hydroxylase activity", "d": ["Catalysis of the reaction: beta-carotene + 2 NADH + 2 H+ + 2 O2 = (2R,2'R)-dihydroxy-all-trans-beta-carotene + 2 NAD + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35882", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29060", "l": "2 H(+)(in) + H2 + ubiquinone-8 => 2 H(+)(out) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396370", "l": "VTN binds collagens II, III and V (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444572", "l": "Zinc is an agonist of GPR39 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102698", "l": "5-epi-aristolochene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-5-epi-aristolochene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391936", "l": "EP1 receptor can bind PGE2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48720", "l": "aurachin B + H2O + NAD(+) = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH", "d": []}, {"i": "EC:1.1.1.394", "l": "\"aurachin B dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417820", "l": "P2Y9 receptor can bind to LPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818682", "l": "MEN1 binds MLL2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34944", "l": "hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) => arbutin 6-phosphate(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390909", "l": "HRH2 binds hist (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50267", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047528", "l": "2,3-dihydroxyindole 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxyindole + O2 = anthranilate + CO2 + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047372", "l": "acylglycerol lipase activity", "d": ["Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018658", "l": "salicylate 1-monooxygenase activity", "d": ["Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635892", "l": "ATF4 binds the ATF3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43282", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10397", "l": "an L-alpha-amino acid + H2O + NAD(+) => a 2-oxocarboxylate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42342", "l": "4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH => 4-(gamma-L-glutamylamino)butanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674140", "l": "PAQR3 binds inactive RAFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73932", "l": "Resynthesis of excised residue by POLB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63109", "l": "16-hydroxy-ilicicolin A epoxide => ascofuranol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75616", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate => ectocarpin B + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22091", "l": "ATP + GTP <=> AMP + guanosine 3'-diphosphate 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69054", "l": "3 H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+) => H(+) + N(omega)-methyl-L-arginine + 2 NADH + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429815", "l": "Formation Of Bloc-1 Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627056", "l": "Procaspase 9 forms dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72697", "l": "Start codon recognition (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018766", "l": "RHOU binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70903", "l": "(2R)-3-phospho-glyceroyl phosphate + 2-deoxy-alpha-D-ribose 1-phosphate = (2R)-3-phosphoglycerate + 2-deoxy-alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27454", "l": "iodide + L-tyrosine + NADP(+) => 3-iodo-L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799350", "l": "Exocytosis of specific granule membrane proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33830", "l": "ergosterol <=> vitamin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56189", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51994", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202375", "l": "Recruitment of ITK to SLP-76 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120328", "l": "ATP-dependent DNA (cytosine-5-)-methyltransferase activity", "d": ["Catalytic activity that acts to transfer a methyl group to a DNA molecule, driven by ATP hydrolysis."]}, {"i": "RHEA:68984", "l": "a 2'-deoxycytidine in DNA + ATP + H2O + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + ADP + 2 H(+) + phosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692241", "l": "Expression of SRY in testis differentiation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39378", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA <=> (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37869", "l": "1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20455", "l": "H(+) + scopolin + UDP => scopoletin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417842", "l": "P2Y10 receptor can bind to LPA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61560", "l": "gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37072", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71370", "l": "epiandrosterone 3-sulfate(out) + 2 Na(+)(out) <=> epiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.-", "l": "\"Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39879", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol = a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0140995", "l": "histone H2A kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone H2A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749197", "l": "ORC1 binds to H4K20me2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57255", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP <=> glycolate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31305", "l": "an oxidized flavin + 2 H(+) + NADH => a reduced flavin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74341", "l": "O-3-methylbutanoyl-(R)-carnitine(out) => O-3-methylbutanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198314", "l": "DAG stimulates protein kinase C-delta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43068", "l": "beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.126", "l": "\"beta-amyrin 28-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9660557", "l": "RAS:GTP binds RAL GDS proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57138", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42099", "l": "ATP + carbamoyl phosphate + H2O + tobramycin <=> AMP + diphosphate + H(+) + nebramycin 5' + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69199", "l": "ATP + L-glutamate + L-glutamyl-[beta-tubulin] <=> ADP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.13", "l": "\"ADP-ribose diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112123", "l": "Oxidative demethylation of 1-meA damaged DNA By ALKBH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641147", "l": "DACT1 binds DVL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421835", "l": "trans-Golgi Network Vesicle Scission (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047136", "l": "4-(dimethylamino)phenylazoxybenzene reductase activity", "d": ["Catalysis of the reaction: 4-(dimethylamino)azobenzene + H2O + NADP+ = 4-(dimethylamino)phenylazoxybenzene + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791064", "l": "Expression of ARFGAP1 (GAP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796691", "l": "SPATA2 links CYLD to LUBAC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45046", "l": "2 Fe(III)-[cytochrome c] + H2O + nitrite => 2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005140", "l": "interleukin-9 receptor binding", "d": ["Binding to an interleukin-9 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74260", "l": "H2O + L-homoseryl-tRNA(Lys) => H(+) + L-homoserine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981353", "l": "RASA1 stimulates RAS GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9706399", "l": "RHOBTB3 hydrolyzes ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981892", "l": "Active G alpha (z) binds RGS proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008336", "l": "gamma-butyrobetaine dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O2 = carnitine + CO2 + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60288", "l": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.366", "l": "\"[histone H3]-N(6),N(6)-dimethyl-lysine(9) N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10978", "l": "5,6-dihydroquinoline-2,5,6-triol + NAD(+) => H(+) + NADH + O2 + quinolin-2-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54962", "l": "AMP + dinor-OPDA-CoA + diphosphate => ATP + CoA + dinor-OPDA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48721", "l": "aurachin B + H2O + NAD(+) => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140762", "l": "glucose dehydrogenase (FAD, quinone) activity", "d": ["Catalysis of the reaction: a quinone + D-glucose = a quinol + D-glucono-1,5-lactone."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990272", "l": "anti-Mullerian hormone receptor activity", "d": ["Combining with anti-Mullerian hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18907", "l": "acetaldehyde + H(+) + phosphate => H2O + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166215", "l": "FA spontaneously flip-flops back to the matrix side (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29476", "l": "(2E,6E)-farnesyl diphosphate => (+)-cubenene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53022", "l": "a 2-oxocarboxylate + a plastoquinol + NH4(+) => a plastoquinone + an L-alpha-amino acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57924", "l": "H2O + mutildienyl diphosphate = diphosphate + premutilin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183122", "l": "Factor D cleaves C3b-bound Factor B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627104", "l": "XIAP binds CASP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31378", "l": "H(+) + pyrrole-2-carboxylate <=> 1H-pyrrole + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050283", "l": "serine-sulfate ammonia-lyase activity", "d": ["Catalysis of the reaction: L-serine O-sulfate + H2O = pyruvate + NH3 + sulfate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047729", "l": "carnitine decarboxylase activity", "d": ["Catalysis of the reaction: carnitine + H+ = 2-methylcholine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55398", "l": "(3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine => (R)-carnitine + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189488", "l": "UROS transforms HMB to URO3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0047635", "l": "alanine-oxo-acid transaminase activity", "d": ["Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70612", "l": "L-lysyl-[protein] + tetradecanoyl-[ACP] => H(+) + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61582", "l": "(5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH => (3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13495", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH => (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32959", "l": "H2O + L-isoleucine + NAD(+) = (S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16317", "l": "(S)-indan-1-ol + NAD(+) = H(+) + indan-1-one + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674019", "l": "BRAP binds KSR1:MARK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54996", "l": "3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46256", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74712", "l": "Dissociation of IRS-P from insulin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16268", "l": "O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate <=> 5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082356", "l": "HSF1-mediated gene expression (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004461", "l": "lactose synthase activity", "d": ["Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875443", "l": "USP8 deubiquitinates LRIG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797961", "l": "CHDH oxidises Cho to BETALD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58951", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682769", "l": "LGI2 binds ADAM22,23 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42981", "l": "L-tyrosine => 2-aminoprop-2-enoate + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35200", "l": "(S,S)-tartrate(out) => (S,S)-tartrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389956", "l": "Beta-tubulin:GTP + Cofactor A ->  Beta-tubulin:GTP: Cofactor A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64693", "l": "isobutanol + NAD(+) => 2-methylpropanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65730", "l": "CO2 + H(+) + hexanal + succinate + sulfate => 2-oxoglutarate + hexyl sulfate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45573", "l": "[(1->4)-beta-D-mannuronosyl](n) => [alginate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14000", "l": "3-methyl-2-oxobutanoate + CoA + NAD(+) <=> 2-methylpropanoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29483", "l": "(2E,6E)-farnesyl diphosphate = (+)-beta-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62206", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + propanal => 1-propanol + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018760", "l": "thiocyanate hydrolase activity", "d": ["Catalysis of the reaction: H2O + 2 H+ + thiocyanate = carbonyl sulfide + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51827", "l": "ATP(in) + CoA(in) + H(+)(out) + octanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706720", "l": "SARS-CoV-1 E transports Ca2+  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70040", "l": "3-dehydro-6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 3-dehydroteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13085", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = CoA + L-2-acetamido-6-oxoheptanedioate", "d": []}, {"i": "EC:2.3.1.89", "l": "\"tetrahydrodipicolinate N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214853", "l": "WEK and MYD88:TUB bind to the TL receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56796", "l": "ATP + cob(I)alamin-[corrinoid adenosyltransferase] = adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72461", "l": "fumarate(out) + L-aspartate(in) => fumarate(in) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16241", "l": "an NDP-alpha-D-glucose + D-fructose = a ribonucleoside 5'-diphosphate + H(+) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57972", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.169", "l": "\"eupatolide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71610", "l": "(S)-malate(in) + phosphate(out) <=> (S)-malate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353426", "l": "TDG glycosylase mediated recognition and binding of thymine opposite guanine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676264", "l": "Formation of the SET1B complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264865", "l": "Caspase-mediated cleavage of Lamin A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696547", "l": "STAMBPL1 is a deubiquitinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16938", "l": "1-O-alkyl-sn-glycerol + ATP => 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77094", "l": "Formation of cap binding complex (CBC) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69873", "l": "(22S)-22-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholestanol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18269", "l": "ethyl (S)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.280", "l": "\"(S)-3-hydroxyacid-ester dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187332", "l": "Cytosolic CMs translocate to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27706", "l": "ATP + D-alanine + D-serine = ADP + D-alanyl-D-serine + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.35", "l": "\"D-alanine--D-serine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23037", "l": "2 inosine + O2 => 2 5'-dehydroinosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917700", "l": "MVB Vesicle Formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41123", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66114", "l": "(2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate => 2-oxobutanoate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44134", "l": "2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine => 2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034562", "l": "2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity", "d": ["Catalysis of the reaction: 2,2-bis(4-hydroxyphenyl)-1-propanol + NADH + H+ + O2 = 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004712", "l": "protein serine/threonine/tyrosine kinase activity", "d": ["Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.863640214551324", "identifiers": [{"i": "GO:0061629", "l": "RNA polymerase II-specific DNA-binding transcription factor binding", "d": ["Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64915", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790025", "l": "Expression of BCL2, BCL2L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10481", "l": "2-oxoglutarate + 4-hydroxy-L-glutamate => 4-hydroxy-2-oxoglutarate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20274", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664879", "l": "ATM:PEX5 binds ATM (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63272", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686335", "l": "CSF2RA:CSF2RB binds SFTPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610752", "l": "GLI3R translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004421", "l": "hydroxymethylglutaryl-CoA synthase activity", "d": ["Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H2O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55762", "l": "an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP] => a fatty acyl-[ACP] + a lyso-ornithine lipid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198983", "l": "NKG2D homodimer interacting with ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57330", "l": "CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein] => acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63590", "l": "prunetin-4'-O-beta-D-glucuronide + UDP => prunetin + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15352", "l": "L-glutamate + N(2)-acetyl-L-ornithine <=> L-ornithine + N-acetyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18775", "l": "Co(I)-[methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17334", "l": "O-acetyl-L-serine + zeatin => acetate + H(+) + L-lupinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209924", "l": "Dopa is decarboxylated to dopamine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9609921", "l": "SGTA binds Tail-anchored protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0033229", "l": "cysteine transmembrane transporter activity", "d": ["Enables the transfer of cysteine from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987039", "l": "JAK1 binds IL20RA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59112", "l": "ATP + L-serine = ADP + H(+) + O-phospho-L-serine", "d": []}, {"i": "EC:2.7.1.225", "l": "\"L-serine kinase (ATP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60790", "l": "CO2 + gibberellin A9 + H2O => gibberellin A24 + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68603", "l": "ORC5 binds ORC2:ORC3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15625", "l": "Co-precorrin-6B + NAD(+) = Co-precorrin-6A + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.106", "l": "\"cobalt-precorrin-6A reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013147", "l": "RAC1 GDIs block activation of RAC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62148", "l": "dGTP + dTMP = dGDP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388596", "l": "Melanocortin receptors bind melanocortins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46687", "l": "3-oxochol-4-en-24-oyl-CoA + A <=> (22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56597", "l": "(1S,4S)-bornane-2,5-dione + FMNH2 + O2 => (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14079", "l": "beta-alanine + pyruvate => 3-oxopropanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684033", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46187", "l": "ATP + CoA + isovalerate <=> 3-methylbutanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10206", "l": "formaldehyde + methylamine + reduced [electron-transfer flavoprotein] => dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004037", "l": "allantoicase activity", "d": ["Catalysis of the reaction: allantoate + H2O = (S)-ureidoglycolate + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11385", "l": "(S)-2-hydroxyoctadecanoate + NAD(+) => 2-oxooctadecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36439", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72565", "l": "butanoate(in) + dehydroepiandrosterone 3-sulfate(out) => butanoate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784622", "l": "APOA4,APOA5,APOC2,CIDEC,FGF21 genes express APOA4,APOA5,APOC2,CIDEC,FGF21 proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990206", "l": "jasmonyl-Ile conjugate hydrolase activity", "d": ["Catalysis of the reaction: jasmonyl-Ile + H2O = jasmonic acid + L-isoleucine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67922", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.116918913335823", "identifiers": [{"i": "GO:0016796", "l": "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters."]}, {"i": "EC:3.1.15.-", "l": "\"Exonucleases active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.2", "l": "\"dipeptidyl-peptidase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74059", "l": "PDE6 hydrolyses cGMP to GMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65531", "l": "hexan-1-ol + octanoyl-CoA <=> CoA + hexyl octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709109", "l": "DHFR dimer binds DHFR inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46373", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37022", "l": "A + D-serine + H2O <=> 3-hydroxypyruvate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63259", "l": "1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10023", "l": "H2O + L-saccharopine + NADP(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209738", "l": "VD3 binds GC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64512", "l": "(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine = 6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419861", "l": "Melanospin is stimulated by light (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050419", "l": "hydroxymandelonitrile lyase activity", "d": ["Catalysis of the reaction: 4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrocyanate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016430", "l": "tRNA (adenine-N6-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67637", "l": "(2S)-2-amino-2'-deoxyadenylo-succinate => dZMP + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806957", "l": "MET receptor dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45095", "l": "H2O + N-octanoylsphing-4-enine <=> octanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27526", "l": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesol + diphosphate", "d": []}, {"i": "EC:3.1.7.6", "l": "\"farnesyl diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353516", "l": "Ligation of DNA at sites of patch replacement (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25040", "l": "ATP + L-seryl-tRNA(Sec) <=> ADP + O-phospho-L-seryl-tRNA(Sec)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14806", "l": "ATP + D-allose => ADP + D-allose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44077", "l": "ATP + CoA + pentadecanoate => AMP + diphosphate + pentadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950260", "l": "Expression of Proteasome activator complex subunit 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15774", "l": "ATP + dihydroxyacetone => ADP + dihydroxyacetone phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047490", "l": "pectin lyase activity", "d": ["Catalysis of the reaction: a pectin = an oligosaccharide with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronate end + a pectin. This reaction is the eliminative cleavage of (1->4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their nonreducing ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45453", "l": "H2O + N-tetradecanoylethanolamine => ethanolamine + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24064", "l": "2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen", "d": []}, {"i": "EC:4.2.1.24", "l": "\"porphobilinogen synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40648", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74742", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine <=> 7,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19924", "l": "D-ribitol 5-phosphate + NADP(+) <=> D-ribulose 5-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37461", "l": "1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP => 1D-myo-inositol hexakisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16717", "l": "deoxycholate + FAD + H(+) + H2O = cholate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67855", "l": "FMNH2 + O2 <=> FMN-N(5)-peroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210426", "l": "Glutamate synaptic vesicle docking and priming (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022141", "l": "Prolysyl oxidase activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55642", "l": "AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+) => C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47930", "l": "(2S)-3-sulfolactate + 2 H(+) + NADPH => (2S)-3-sulfolactaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114256", "l": "CYCS:APAF1 binds procaspase-9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23565", "l": "2 columbamine + O2 => 2 berberine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0004879", "l": "nuclear receptor activity", "d": ["A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63708", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13132", "l": "cis-4-coumarate + UDP-alpha-D-glucose <=> 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26435", "l": "indole + L-serine => H2O + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655826", "l": "Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70543", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202709", "l": "JAM2 dimerises (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70930", "l": "(R)-glycerate(in) + H(+)(in) <=> (R)-glycerate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018754", "l": "GDIs bind RHOH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14472", "l": "2-aminomuconate 6-semialdehyde + H2O + NAD(+) <=> (2Z,4E)-2-aminomuconate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63203", "l": "(10bS,4aR)-noroxomaritidine + H(+) + NADPH <=> (10bS,4aR)-oxomaritidine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30366", "l": "fumonisin B1 + 2 H2O <=> (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14205", "l": "carnosine + S-adenosyl-L-methionine = anserine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.22", "l": "\"carnosine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42013", "l": "cortisol + NAD(+) => 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37749", "l": "1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015123", "l": "acetate transmembrane transporter activity", "d": ["Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.37", "l": "\"1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007882", "l": "IL1F10 is cleaved (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56791", "l": "apo-[corrinoid adenosyltransferase] + cob(II)alamin <=> cob(II)alamin-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199154", "l": "CD200 binds to CD200R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.25", "l": "\"carvone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25559", "l": "9alpha-copalyl diphosphate <=> diphosphate + stemod-13(17)-ene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60781", "l": "2-oxoglutarate + gibberellin A15 + O2 => CO2 + gibberellin A24 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42933", "l": "cytidine(32) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222712", "l": "Nitrosoglutathione gets cleaved to Cys(NO)-Gly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.135", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2106614", "l": "Duplex miRNA is loaded into Argonaute (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70634", "l": "H2O + N(6)-decanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-decanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42879", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26460", "l": "acetaldehyde + FMN + 2 H(+) + H2O + nitrite => ethylnitronate + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399930", "l": "Activation of PAK by Rac1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418858", "l": "RhoGTPase GEF's recruited to DCC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399939", "l": "Autophosphorylation of PAK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37211", "l": "2',3'-cyclophospho-GMP + H2O = guanosine 2'-monophosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47751", "l": "a ubiquinone + H(+) + n Na(+)(in) + NADH <=> a ubiquinol + n Na(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46946", "l": "H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH => (S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687107", "l": "MAPK4,6 translocate to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42565", "l": "uridine(38/39) in tRNA => pseudouridine(38/39) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11652", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose = alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}, {"i": "EC:2.7.8.6", "l": "\"undecaprenyl-phosphate galactose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25753", "l": "H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25999", "l": "H2O + N(1)-acetylspermine + O2 <=> H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33537", "l": "a carboxylate + H(+) + lanosterol => H2O + lanosteryl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54473", "l": "1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16131", "l": "H(+) + NADPH + pyridoxal => NADP(+) + pyridoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35996", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2484822", "l": "Kinetochore assembly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71110", "l": "L-leucine(out) + S-methylmercury-L-cysteine(in) <=> L-leucine(in) + S-methylmercury-L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635861", "l": "NUMB:ITCH binds GLI1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686359", "l": "SFTPs translocate from extracellular region to clathrin-coated vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196857", "l": "PANK2 phosphorylates PanK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29569", "l": "2 chloride(out) + H(+)(in) => 2 chloride(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177920", "l": "Binding of GRB2 to GAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22957", "l": "1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60013", "l": "a tRNA with a 3' CC end + ATP => a tRNA with a 3' CCA end + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197698", "l": "Src phosphorylate WASP,N-WASP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2247511", "l": "STAB2:ligand is endocytosed (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20416", "l": "glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine <=> glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37129", "l": "CO2 + H(+) + phosphonate + succinate => 2-oxoglutarate + dioxidophosphate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879930", "l": "STAT5 is recruited by JAK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68394", "l": "acetate + H(+) + H2O2 => H2O + peracetic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032770", "l": "Translocation of YAP1 to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483099", "l": "PA translocates from the outer to the inner mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6795460", "l": "SGK1 phosphorylates MDM2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678992", "l": "Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20305", "l": "4-hydroxybenzaldehyde + H2O + NAD(+) = 4-hydroxybenzoate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.64", "l": "\"4-hydroxybenzaldehyde dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13118", "l": "O-acetyl-L-serine + pyrazole => 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45593", "l": "H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621615", "l": "CD209 binds ICAM3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49878", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787737", "l": "CSF3R binds CSF3 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013024", "l": "RHOB binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54600", "l": "2-oxoglutarate + O2 + octanoyl-CoA = 2-hydroxyoctanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45735", "l": "D-ribulose 5-phosphate + L-tyrosine <=> (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050096", "l": "methylaspartate ammonia-lyase activity", "d": ["Catalysis of the reaction: threo-3-methyl-L-aspartate = mesaconate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25295", "l": "acetaldehyde + H2O + NAD(+) => acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451347", "l": "Activation of JNK by DSCAM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229283", "l": "LCNs bind lipids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015607", "l": "ABC-type fatty-acyl-CoA transporter activity", "d": ["Catalysis of the reaction ATP + H2O + fatty acyl CoA(Side 1) <=> ADP + phosphate + fatty acyl CoA(Side 2). A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A group attached to it."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111930", "l": "Adenylate cyclase produces cAMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42490", "l": "3'-N-debenzoyl-2'-deoxytaxol + CoA => (3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011975", "l": "Estrogen-responsive MYC gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16505", "l": "chorismate = 4-hydroxybenzoate + pyruvate", "d": []}, {"i": "EC:4.1.3.40", "l": "\"chorismate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10136", "l": "2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO2", "d": []}, {"i": "EC:4.1.1.47", "l": "\"tartronate-semialdehyde synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60251", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] <=> AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9815510", "l": "MIB2 binds CYLD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035488", "l": "cytosine/thymine mispair binding", "d": ["Binding to a double-stranded DNA region containing a C/T mispair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26238", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (2E,6E,10E)-geranylgeraniol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68827", "l": "(2E)-geranyl diphosphate <=> (Z)-beta-ocimene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13966", "l": "H2O + L,L-cystathionine => L-homocysteine + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805620", "l": "KAT6A and PML bind TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015066", "l": "alpha-amylase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of alpha-amylase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392513", "l": "Rap1 signal termination by Rap1GAPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74986", "l": "Elongation of pre-rRNA transcript (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54071", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O <=> diphosphate + sesterfisherol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60688", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NAD(+) = (11R)-dihydroartemisinate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42643", "l": "a 2-demethylmenaquinol + S-adenosyl-L-methionine <=> a menaquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390641", "l": "ADRA1A,B,D bind ADR,NAd (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9660192", "l": "VDR agonists bind VDR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14823", "l": "L-ribulose => beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700156", "l": "Active ALK dimer binds IRS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69299", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate <=> 3-hydroxypent-4-ene nitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24868", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 <=> 4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018823", "l": "cyclohexa-1,5-dienecarbonyl-CoA hydratase activity", "d": ["Catalysis of the reaction: cyclohexa-1,5-diene-1-carbonyl-CoA + H2O = 6-hydroxycyclohex-1-enecarbonyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785478", "l": "Processed tRNA binds XPOT and RAN:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016287", "l": "glycerone-phosphate O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693061", "l": "STAMBP binds STAM (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12309", "l": "(S)-2-amino-6-oxohexanoate + H2O + NAD(+) => 2 H(+) + L-2-aminoadipate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10535", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine <=> D-glyceraldehyde 3-phosphate + H2O + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769397", "l": "SOST binds LRP5/6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202291", "l": "Activation of Lck (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56645", "l": "a uridine in mRNA => a pseudouridine in mRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33273", "l": "a 1,2-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218804", "l": "p38 MAPK activation by VEGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35405", "l": "(3R)-vestitone + H(+) + NADPH => (3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63558", "l": "dynorphin A-(1-12) + L-lysine => dynorphin A-(1-13) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44331", "l": "1-octanoylglycerol + H2O <=> glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40632", "l": "H2O + trioctadecanoylglycerol => 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034025", "l": "D-aspartate ligase activity", "d": ["Catalysis of the reaction: ATP + D-aspartate + [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45190", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47846", "l": "CO2 + diphosphate + thiamine phosphate => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796225", "l": "TEAD2,TEAD4:YAP1, TBXT, FOXH1, and SMAD2,3 bind the FOXA2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813749", "l": "ALDH1A1 oxidises GA to DGA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.083168145531296", "identifiers": [{"i": "GO:0008233", "l": "peptidase activity", "d": ["Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53820", "l": "chenodeoxycholate + NADP(+) = 7-oxolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0031320", "l": "hexitol dehydrogenase activity", "d": ["Catalysis of the reaction: hexitol + acceptor = hexose + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5334827", "l": "SUMO-CRABP2 binds atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37337", "l": "3-(carbamoylamino)-2-methylpropanoate + H(+) => 5,6-dihydrothymine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9676264", "l": "Formation of the SET1B complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624949", "l": "Assembly of the anterograde IFT train (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168888", "l": "Alpha1-Microglobulin binds heme (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39411", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA = (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696271", "l": "RND1 binds effectors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.14", "l": "\"zinc D-Ala-D-Ala carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379893", "l": "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57929", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine => ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201443", "l": "Type II receptor phosphorylates type I receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47815", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3159253", "l": "MMAB adenosylates cob(I)alamin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849435", "l": "PTPN1 dephosphorylates PTK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20999", "l": "(2Z,4E)-2-aminomuconate + H2O <=> (3E)-2-oxohex-3-enedioate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31930", "l": "3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43207", "l": "cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72906", "l": "butyrolactone II + dimethylallyl diphosphate <=> butyrolactone I + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102744", "l": "all-trans-geranyl-geranyl diphosphate reductase activity", "d": ["Catalysis of the reaction: H+ + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + NADPH = dihydrogeranylgeranyl-PP + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102569", "l": "FR-33289 synthase activity", "d": ["Catalysis of the reaction: FR-900098 + 2-oxoglutarate(2-) + O2 <=> FR-33289 + succinate(2-) + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679239", "l": "ULK complex translocates to the ER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691174", "l": "RAC1 binds effectors at the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16903", "l": "(2S)-4-acetamido-2-aminobutanoate + CoA + H(+) => acetyl-CoA + L-2,4-diaminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50544", "l": "prostaglandin C2 = prostaglandin B2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40518", "l": "6-deoxy-6-sulfo-D-fructose 1-phosphate <=> (2S)-3-sulfolactaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052670", "l": "geraniol kinase activity", "d": ["Catalysis of the reaction: geraniol + nucleoside triphosphate = geranyl monophosphate + nucleoside diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65028", "l": "(+)-pinoresinol + H2O + 2 oxidized [azurin] = (+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin]", "d": []}, {"i": "EC:1.17.9.2", "l": "\"(+)-pinoresinol hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48876", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52977", "l": "a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] => a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661419", "l": "ALB binds extracellular heme (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865090", "l": "UBA6 adenylates ubiquitin in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50573", "l": "acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63725", "l": "candesartan + UDP-alpha-D-glucuronate => candesartan O-beta-D-glucuronoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29298", "l": "aldehydo-D-galacturonate(out) + H(+)(out) <=> aldehydo-D-galacturonate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.481603666032214", "identifiers": [{"i": "GO:0061134", "l": "peptidase regulator activity", "d": ["Binds to and modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685602", "l": "NCR3LG1 binds NCR3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627737", "l": "SLC26A3 does not exchange Cl- for HCO3- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14210", "l": "alpha-D-galactose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176517", "l": "SULTs transfer (SO4)2- group to PREG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166542", "l": "beta-NGF dimer binds to TrkA receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376140", "l": "Ena/VASP proteins bind ROBO1:SLIT2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823995", "l": "Expression of E-cadherin (CDH1) in definitive endoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678843", "l": "ISGylation of protein translation regulator 4EHP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13130", "l": "cis-4-coumarate + UDP-alpha-D-glucose => 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045545", "l": "syndecan binding", "d": ["Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24254", "l": "2 ADP + 2 H(+) => H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63943", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2 <=> 2 Fe(III)-[cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675790", "l": "MTORC1 dissociates from ULK complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42640", "l": "a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74491", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B = yaequinolone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944223", "l": "Association of procollagen type V (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47575", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E)) <=> CMP + ganglioside GT1b (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37752", "l": "2-methyl-trans-aconitate => 2-methyl-cis-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28652", "l": "inosine + O2 => 9-riburonosylhypoxanthine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15932", "l": "2 H(+) + 2 H2O + methylenediurea <=> CO2 + N-(hydroxymethyl)urea + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31948", "l": "ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase] => ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42550", "l": "pseudouridine(746) in 23S rRNA => uridine(746) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58620", "l": "N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008199", "l": "ferric iron binding", "d": ["Binding to a ferric iron ion, Fe(III)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21498", "l": "diphosphate + prenol => dimethylallyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25863", "l": "GTP + H2O <=> 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26458", "l": "ethylnitronate + FMNH2 + O2 = acetaldehyde + FMN + 2 H(+) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50534", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047985", "l": "hydrogen dehydrogenase activity", "d": ["Catalysis of the reaction: H2 + NAD+ = H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15003", "l": "5-dehydro-D-fructose + H(+) + NADPH => keto-L-sorbose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69265", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate => an isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901039", "l": "MAN1B1 hydrolyses 1,2-linked mannose (c branch) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392834", "l": "Activation of EPACs by cAMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008013", "l": "beta-catenin binding", "d": ["Binding to a catenin beta subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29558", "l": "H2O + UDP-alpha-D-glucose <=> alpha-D-glucose 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420131", "l": "The PACAP receptor binds PACAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55531", "l": "H(+) + H2O + L-tyrosine + O2 <=> (4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65975", "l": "a peptide antigen(in) + ATP + H2O <=> a peptide antigen(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156930", "l": "GTP-binding activates eEF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047565", "l": "3-hydroxypropionate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: 3-hydroxypropanoate + NAD+ = 3-oxopropanoate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682026", "l": "MRN bound to shortened telomeres activates ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186778", "l": "SHP2 binds to the active receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74173", "l": "an alcohol + CO2 + methylamine => an N-methyl carbamate ester + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43359", "l": "cholesteryl (9Z,12Z)-octadecadienoate(in) <=> cholesteryl (9Z,12Z)-octadecadienoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63844", "l": "[thioredoxin]-dithiol + cumene hydroperoxide = 2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56077", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29261", "l": "(2R,3R)-tartrate(in) + succinate(out) => (2R,3R)-tartrate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73223", "l": "(3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68040", "l": "(R)-lanthionine ketimine + 2 H(+) + NADPH = (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48263", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 <=> CMP + ganglioside GD1a + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25016", "l": "H(+) + N,N-dihydroxy-L-tryptophan <=> (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34096", "l": "carboxyspermidine + H(+) => CO2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174202", "l": "Degradation of multiubiquitinated Securin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49019", "l": "aurachin C epoxide <=> 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58095", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53692", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O = H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798743", "l": "Exocytosis of secretory granule membrane proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850794", "l": "SPINK6 binds KLK5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9659611", "l": "ANO1 inhibitors bind ANO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749494", "l": "IKBIP binds IKBKB and CHUK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047544", "l": "2-hydroxybiphenyl 3-monooxygenase activity", "d": ["Catalysis of the reaction: biphenyl-2-ol + H+ + NADH + O2 = biphenyl-2,3-diol + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46362", "l": "1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74518", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B <=> aspoquinolone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102869", "l": "6-hydroxyflavone-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 6-hydroxyflavone <=> 6-O-beta-D-glucosyl-6-hydroxyflavone + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73925", "l": "griseophenone D + H(+) + S-adenosyl-L-homocysteine => 2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28600", "l": "acetate + L-lysine => H2O + N-acetyl-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34591", "l": "Co-precorrin-7 + S-adenosyl-L-methionine = Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.289", "l": "\"cobalt-precorrin-7 (C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48786", "l": "D-erythrose 4-phosphate => D-erythrulose 4-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36090", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166038", "l": "GPI-bound CD14 binds LPS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41855", "l": "H(+) + malonyl-[ACP] + octanoyl-[ACP] <=> 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18759", "l": "CO2 + cylindrospermopsin + succinate => 2-oxoglutarate + 7-deoxycylindrospermopsin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0051429", "l": "corticotropin-releasing hormone receptor binding", "d": ["Binding to a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13209", "l": "A + 3 H2O + trithionate = AH2 + 4 H(+) + 3 sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19768", "l": "glycerol <=> 3-hydroxypropanal + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202947", "l": "Caspase mediated cleavage of APC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1449687", "l": "Corticosteroids bind to CBG in blood (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73359", "l": "ATP + beta-alanine + dopamine = AMP + beta-alanyl-dopamine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191303", "l": "FDPS dimer transfers IPPP to GPP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50881", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol => 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624272", "l": "MMPs cleave HB-EGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388468", "l": "AVP(20-28) binds AVPR1A,B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8934742", "l": "RUNX1 binds PRMT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43082", "l": "2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388830", "l": "PI3K binds ICOS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873946", "l": "OTUD3 deubiquitinates PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.123", "l": "\"[cytochrome c]-methionine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16398", "l": "2 D-glucopyranose 1-phosphate => D-glucose + D-glucose 1,6-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.375", "l": "\"rhamnogalacturonan I galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59779", "l": "D-arabinitol + O2 <=> D-arabinose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848939", "l": "PTK6 binds KHDRBS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936631", "l": "sulfate uptake in the cytosol (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168038", "l": "Collagen type XV restin release (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33894", "l": "chanoclavine-I + NAD(+) <=> chanoclavine-I aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59206", "l": "AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+) => docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45463", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51739", "l": "L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59101", "l": "diglucosyl-enterobactin + UDP-alpha-D-glucose => H(+) + triglucosyl-enterobactin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28703", "l": "Cu(2+)(in) = Cu(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033925", "l": "mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity", "d": ["Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26480", "l": "a 2-demethylmenaquinol + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38755", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n3", "l": "\"ISG15--protein ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944216", "l": "Association of procollagen type XV (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.114", "l": "\"methanogen homoaconitase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20578", "l": "3-hydroxyaminophenol => aminohydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58890", "l": "4-nitrobenzoate + A + 2 H2O => 4-aminobenzoate + AH2 + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68685", "l": "3'-phosphoadenylyl sulfate + testosterone 17-O-(beta-D-glucuronate) => adenosine 3',5'-bisphosphate + H(+) + testosterone 17-O-(3-sulfo-beta-D-glucuronate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707505", "l": "Hemes bind to CLEC1B dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987120", "l": "JAK1 binds IFNLR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75589", "l": "erinacine Q2 + H(+) + UDP => 11-O-acetylcyathatriol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018542", "l": "2,3-dihydroxy DDT 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxy DDT + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8,8-tetrachloroocta-2E,4E-dienoate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031370", "l": "eukaryotic initiation factor 4G binding", "d": ["Binding to eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15214", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA => (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24239", "l": "2 Fe(III)-[cytochrome c] + H2O + trimethylamine <=> 2 Fe(II)-[cytochrome c] + 3 H(+) + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382096", "l": "Formation of NR-NCOR Corepressor Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63544", "l": "H2O + kinetensin = kinetensin-(1-8) + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983696", "l": "The Immunoglobulin of the BCR binds antigen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682377", "l": "LC3 de-lipidation by ATG4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29418", "l": "(S)-lactate(in) + H(+)(in) <=> (S)-lactate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64991", "l": "CoA + H2O <=> (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042084", "l": "5-methyltetrahydrofolate-dependent methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58382", "l": "H(+) + NADPH + nonanal => NADP(+) + nonan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950342", "l": "EBI3:CANX binds IL27 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32125", "l": "citrate(out) + H(+)(out) => citrate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43803", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102400", "l": "dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N,N-dimethyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose <=> 2 S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33644", "l": "(9Z)-tetradecenoate + ATP + CoA => (9Z)-tetradecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0034739", "l": "histone H4K16 deacetylase activity", "d": ["Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050158", "l": "dihydroorotate dehydrogenase (NADPH) activity", "d": ["Catalysis of the reaction: (S)-dihydroorotate + NADP+ = H+ + NADPH + orotate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031814", "l": "P2Y4 nucleotide receptor binding", "d": ["Binding to a P2Y4 nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129353", "l": "Tropoelastin associates with microfibrils (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17642", "l": "H(+) + L-arginine => agmatine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41862", "l": "(2E)-decenoyl-[ACP] + H2O => (3R)-hydroxydecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66393", "l": "ATP + H2O + prostaglandin E1(in) => ADP + H(+) + phosphate + prostaglandin E1(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75855", "l": "9-cis-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] = 9-cis-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399981", "l": "AKT1 E17K mutant phosphorylates MDM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75375", "l": "inosine(in) = inosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050394", "l": "viomycin kinase activity", "d": ["Catalysis of the reaction: ATP + viomycin = ADP + O-phosphoviomycin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47138", "l": "AMP + diphosphate + lithocholoyl-CoA => ATP + CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33316", "l": "a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46867", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) <=> a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68602", "l": "3-oxopropane-1-sulfonate + H2O => (2S)-3-sulfopropanediol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27333", "l": "6-hydroxynicotinate + 2 H(+) + NADH + O2 = 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.114", "l": "\"6-hydroxynicotinate 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250978", "l": "botG LC cleaves target cell VAMP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13003", "l": "1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714481", "l": "RAC2 binds effectors at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371554", "l": "HSF1 acetylation at Lys80 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30574", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine <=> 6 AMP + 6 diphosphate + enterobactin + 4 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050260", "l": "ribose-5-phosphate-ammonia ligase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + ATP + NH4 = 5-phospho-D-ribosylamine + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008942", "l": "nitrite reductase [NAD(P)H] activity", "d": ["Catalysis of the reaction: ammonium hydroxide + 3 NAD(P)+ + H2O = nitrite + 3 NAD(P)H + 3 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36458", "l": "ATP + H2O + L-alanylglycine(out) <=> ADP + H(+) + L-alanylglycine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678981", "l": "TLR9 processing at neutral pH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73800", "l": "SAICAR => AICAR + Fumarate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0097266", "l": "phenylacetyl-CoA 1,2-epoxidase activity", "d": ["Catalysis of the reaction: phenylacetyl-CoA + H+ + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40120", "l": "H2O + tetradecanoyl-CoA => CoA + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696947", "l": "USP47 deubiquitinates POLB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35482", "l": "(1'S,5'R)-5'-hydroxyaverantin + NAD(+) <=> (S)-5'-oxoaverantin + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2530445", "l": "CD59 inhibits MAC formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18846", "l": "(R)-glycerate + NAD(+) => 2-hydroxy-3-oxopropanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391942", "l": "IP receptor can bind prostacyclin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40146", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O <=> (9Z,12Z)-octadecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67282", "l": "(1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione => (2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63648", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17087", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2 => 4-pyridoxate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "46.247628958817685", "identifiers": [{"i": "GO:0005216", "l": "monoatomic ion channel activity", "d": ["Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54217", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 => 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22934", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17198", "l": "2 3-(4-hydroxyphenyl)pyruvate + O2 => 2 4-hydroxyphenylacetate + 2 CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33979", "l": "DIBOA beta-D-glucoside + H2O = D-glucose + DIBOA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013147", "l": "RAC1 GDIs block activation of RAC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034543", "l": "5-aminosalicylate dioxygenase activity", "d": ["Catalysis of the reaction: 5-aminosalicylate + O2 = cis-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416929", "l": "PTGFR binds PGF2a (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53034", "l": "17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP => 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.133", "l": "\"N(alpha)-acyl-L-glutamine aminoacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39616", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA => (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47816", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48648", "l": "lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71323", "l": "chloride(out) + L-asparagine(out) + 2 Na(+)(out) = chloride(in) + L-asparagine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0031685", "l": "adenosine receptor binding", "d": ["Binding to an adenosine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192123", "l": "CYP27A1 27-hydroxylates CHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62220", "l": "phyllostine = neopatulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72605", "l": "(E)-sinapoyl-AMP + diphosphate => (E)-sinapate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111879", "l": "PIP2 hydrolysis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709317", "l": "CO binds to free ferrohemoglobin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16426", "l": "formaldehyde + H2O + NAD(+) => formate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139919", "l": "Translocation of BIM to mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008808", "l": "cardiolipin synthase activity", "d": ["Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56436", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664879", "l": "ATM:PEX5 binds ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36322", "l": "2 H(+) + 2 NADPH + octadecanoyl-CoA <=> CoA + 2 NADP(+) + octadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43962", "l": "a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18367", "l": "CO2 + NADH + pyruvate => (R)-malate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20015", "l": "H(+) + N-carbamoyl-L-aspartate + phosphate => carbamoyl phosphate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39232", "l": "3-oxo-triacontanoyl-CoA + H(+) + NADPH => (3R)-hydroxytriacontanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20030", "l": "10-deoxysarpagine + NADP(+) => H(+) + NADPH + vellosimine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395320", "l": "Latent TGF-beta-1 binds integrins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11782", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389083", "l": "Autophosphorylation of PDGF alpha receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38714", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62552", "l": "beta-D-glucosylceramide + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062078", "l": "TSC1-TSC2 complex binding", "d": ["Binding to a TSC1-TSC2 complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38391", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57596", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.20", "l": "\"prostamide/prostaglandin F2alpha synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395768", "l": "LPL hydrolyses TGs from mature CMs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0039706", "l": "co-receptor binding", "d": ["Binding to a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64769", "l": "S-3-(hexan-1-ol)-L-cysteine => 2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74307", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + NAD(+) = 12alpha-hydroxy-3-oxochola-4-en-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015044", "l": "rubredoxin-NAD+ reductase activity", "d": ["Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606807", "l": "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24278", "l": "acetyl phosphate + phosphate => acetate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46663", "l": "H(+) + NADPH + progesterone <=> 5beta-pregnan-3,20-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63982", "l": "4-thiouridine 5'-phosphate + ADP + H(+) => 4-thiouridine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36763", "l": "alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38681", "l": "ADP + H(+) + phosphate + sphinganine(out) => ATP + H2O + sphinganine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48039", "l": "globoside Gb4Cer (d18:1(4E)) + H2O <=> globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166015", "l": "Association of LBP with LPS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35661", "l": "GDP + H(+) + mannosylinositol phosphorylphytoceramide => an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9704297", "l": "CHRM2 binds CHRM2 antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450533", "l": "PKCdelta phosphorylates HuR (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818937", "l": "MEN1 binds MLL1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888589", "l": "Release of GABA at the synapse (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12011", "l": "[G-protein-coupled receptor] + ATP <=> [G-protein-coupled receptor]-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10261", "l": "ATP + H2O + Mg(2+)(out) => ADP + H(+) + Mg(2+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36691", "l": "octadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43373", "l": "an N-acylsphing-4-enine + dTDP-alpha-D-glucose => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74648", "l": "GTP + N-acetyl-D-glucosamine => GDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17195", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.81", "l": "\"hydroxypyruvate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35596", "l": "benzene-1,2,4-triol + O2 => 2 H(+) + maleylacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23261", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+) => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109701", "l": "PDPK1 binds PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30057", "l": "(2S)-2-amino-3-oxobutanoate + H(+) + NADPH => L-allo-threonine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098851", "l": "double-stranded miRNA binding", "d": ["Binding to double-stranded miRNA. double-stranded miRNA is formed by processing of pre-miRNA stem-loop structures."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177920", "l": "Binding of GRB2 to GAB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9008043", "l": "MAPK8 phosphorylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44022", "l": "2 H(+) + NADH + octadecanoate => H2O + NAD(+) + octadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52424", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38013", "l": "chlorophyllide a + H(+) + phytol => chlorophyll a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64974", "l": "dUMP + H(+) + phosphate => dUDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202534", "l": "Ubiquitination of NEMO by TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21913", "l": "CoA + H(+) + O2 + pyruvate => acetyl-CoA + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17428", "l": "CoA + NADP(+) + pyruvate <=> acetyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40220", "l": "H2O + malonyl-CoA => CoA + H(+) + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68433", "l": "lutein + O2 => (3R)-hydroxy-beta-ionone + (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30541", "l": "(S)-carnitinyl-CoA => (R)-carnitinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37887", "l": "S-adenosyl-L-methionine + small RNA 3'-end nucleotide = H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide", "d": []}, {"i": "EC:2.1.1.386", "l": "\"small RNA 2'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709663", "l": "SARS-CoV-2 9b binds TOMM70 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193641", "l": "IKK-beta is recruited (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672973", "l": "MAP2Ks phosphorylate MAPKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30233", "l": "(2E,6E)-farnesal + H2O2 + L-cysteine => H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.3.5", "l": "\"renalase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72566", "l": "butanoate(out) + dehydroepiandrosterone 3-sulfate(in) <=> butanoate(in) + dehydroepiandrosterone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41431", "l": "L-tyrosine + S-adenosyl-L-methionine <=> 3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420883", "l": "Opsins act as GEFs for G alpha-t (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57067", "l": "D-apionolactone + H2O <=> D-apionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53105", "l": "4-hydroxyestrone + S-adenosyl-L-methionine => 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74771", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine = 3,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15067", "l": "agmatine + benzoate => H2O + N(4)-benzoylagmatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683735", "l": "CHEK2 is recruited to DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49995", "l": "H(+) + NADH + O2 + propane <=> H2O + NAD(+) + propan-2-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.366", "l": "\"ginsenoside F1 6-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354097", "l": "Activation of Talin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14525", "l": "A + beta-cyclopiazonate = AH2 + alpha-cyclopiazonate", "d": []}, {"i": "EC:1.21.99.1", "l": "\"beta-cyclopiazonate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68688", "l": "3'-phosphoadenylyl sulfate + 3beta-androst-5-en-17-one 3-O-(beta-D-glucuronate) = 3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28707", "l": "Cd(2+)(in) = Cd(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399712", "l": "Activation of Ca permeable AMPA receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042907", "l": "xanthine transmembrane transporter activity", "d": ["Enables the transfer of xanthine from one side of a membrane to the other. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62143", "l": "dTMP + GTP <=> dTDP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32528", "l": "N,N'-diacetylchitobiose + phosphate => N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72440", "l": "(E)-ferulate + ATP + H(+) => (E)-feruloyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031732", "l": "CCR7 chemokine receptor binding", "d": ["Binding to a CCR7 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610732", "l": "GSK3 phosphorylates p-GLI3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29546", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35695", "l": "(3S)-versiconol acetate + NADP(+) = (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40804", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) => 3,6-anhydro-L-galactonate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53562", "l": "18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665727", "l": "FMNL2 binds CDC42:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43482", "l": "1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042071", "l": "leucokinin receptor activity", "d": ["Combining with a leucokinin, any of several octapeptide hormones found in insects, and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40348", "l": "3-oxotetradecanedioyl-CoA + CoA => acetyl-CoA + dodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605595", "l": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9646685", "l": "Aggresome dissociates from dynein and microtubule (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26159", "l": "D-mannose + NADP(+) <=> D-glucosone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69662", "l": "H2O + kaempferol 3-O-beta-D-glucoside <=> beta-D-glucose + kaempferol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43404", "l": "N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193695", "l": "IRAK interacts with TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23266", "l": "15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27455", "l": "3-iodo-L-tyrosine + NADPH => iodide + L-tyrosine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0015651", "l": "quaternary ammonium group transmembrane transporter activity", "d": ["Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25885", "l": "carbamoyl phosphate + N(2)-succinyl-L-ornithine => H(+) + N(2)-succinyl-L-citrulline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35389", "l": "2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine => precorrin-7 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769143", "l": "NPAS4 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39040", "l": "an omega-oxo fatty acid + H2O + NAD(+) => a dicarboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5627072", "l": "RHOQ binds GOPC:CFTR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44386", "l": "1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64357", "l": "2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 => (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27603", "l": "(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate => di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52464", "l": "17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030911", "l": "TPR domain binding", "d": ["Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848930", "l": "PTK6 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11498", "l": "3-(uracil-1-yl)-L-alanine + acetate + H(+) => O-acetyl-L-serine + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32773", "l": "2,6-dioxo-6-phenylhexa-3-enoate => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662620", "l": "MT3 binds cadmium (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3858482", "l": "DVL is recruited to the receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14174", "l": "dimethylallyl diphosphate + L-tryptophan => 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28831", "l": "D-gluconate(in) + H(+)(in) = D-gluconate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31731", "l": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.12", "l": "\"3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.10", "l": "\"NADPH dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42075", "l": "(4Z)-2-oxohept-4-enedioate + H2O <=> (4S)-4-hydroxy-2-oxoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21287", "l": "all-trans-retinol + NAD(+) <=> all-trans-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50758", "l": "2 H(+) + NADPH + oxidized [flavodoxin] => NADP(+) + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5658438", "l": "SPRED dimer binds NF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23076", "l": "4-chlorobenzoyl-CoA + chloride + NADP(+) = 2,4-dichlorobenzoyl-CoA + NADPH", "d": []}, {"i": "EC:1.21.1.2", "l": "\"2,4-dichlorobenzoyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858475", "l": "ppDVL recruits RAC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34059", "l": "agroclavine + NADP(+) = didehydroagroclavine + H(+) + NADPH", "d": []}, {"i": "EC:1.5.1.46", "l": "\"agroclavine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420980", "l": "Activation of Ca permeable AMPA receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56288", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.74", "l": "\"albendazole monooxygenase (hydroxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63771", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052815", "l": "medium-chain acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. A medium chain is a chain of between eight and twelve carbons in length."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54864", "l": "H(+) + NADPH + O2 + sulcatone = 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47749", "l": "a ubiquinone + H(+) + n Na(+)(in) + NADH => a ubiquinol + n Na(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047762", "l": "caffeate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: trans-caffeate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29654", "l": "agmatine(in) + L-arginine(out) <=> agmatine(out) + L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41360", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799199", "l": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59890", "l": "A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+) => 4-chloro-L-lysine + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41321", "l": "1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621042", "l": "TF gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617828", "l": "TRIP11:IFT20 dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53998", "l": "(14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858252", "l": "HDLBP binds HDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3785768", "l": "MRN complex binds DNA double strand breaks (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35639", "l": "(4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847977", "l": "FRK phosphorylates PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55674", "l": "4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265987", "l": "Phosphorylation of BRCA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850786", "l": "SPINK6 binds KLK12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58114", "l": "acetate + ADP-D-ribose + H(+) => 1''-O-acetyl-ADP-alpha-D-ribose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38128", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol => 1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12790", "l": "an alditol + NADP(+) => an aldose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18295", "l": "AMP + diphosphate + oxalyl-CoA => ATP + CoA + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40532", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071795", "l": "K11-linked polyubiquitin modification-dependent protein binding", "d": ["Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 11 in the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909724", "l": "Recruitment of IFNAR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.39", "l": "\"xyloglucan 6-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50977", "l": "prostaglandin D2(out) => prostaglandin D2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008915", "l": "lipid-A-disaccharide synthase activity", "d": ["Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67910", "l": "a primary alcohol + H(+) + sulfate => a primary linear alkyl sulfate ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052873", "l": "FMN reductase (NADPH) activity", "d": ["Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67411", "l": "gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + thymol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34583", "l": "2-oxoglutarate + O2 + pentalenolactone D = CO2 + H2O + pentalenolactone E + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49570", "l": "(3R)-3,4-epoxy-3-methylbut-1-ene + glutathione => 2-glutathionyl-2-methylbut-3-en-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805061", "l": "CK2 binds FACT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51742", "l": "a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16112", "l": "ATP + beta-D-fructose 6-phosphate <=> ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71890", "l": "GTP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48220", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA = (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73917", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + 6 CO2 + 7 CoA + H2O => acetyl-CoA + 4 H(+) + 6 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14939", "l": "all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52297", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11267", "l": "H(+) + NADH + O2 <=> H2O2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74267", "l": "n H(+)(out) + spermidine(in) = n H(+)(in) + spermidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140803", "l": "NAD+- protein-cysteine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-cysteinyl-[protein] + NAD+ = H+ + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]."]}, {"i": "RHEA:56612", "l": "L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934742", "l": "RUNX1 binds PRMT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12897", "l": "2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] = (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.137", "l": "\"(+)-abscisic acid 8'-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72180", "l": "Cleavage of mRNA at the 3'-end (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68981", "l": "NADP(+) + tauroursodeoxycholate => 7-oxotaurolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64839", "l": "2-phenylethanol + acetyl-CoA <=> CoA + phenethyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71598", "l": "2-oxoglutarate(out) + succinate(in) <=> 2-oxoglutarate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49608", "l": "2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) = 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44655", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24847", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + 2 H2O <=> 2 isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13424", "l": "an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate <=> an N-acylneuraminate 9-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211874", "l": "CYP2S1 4-hydroxylates atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9727607", "l": "MME:Zn2+ binds sacubitrilat (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981621", "l": "Neuroglobin:oxygen dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34700", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-isocomene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730892", "l": "Recruitment of VAV to p-SLP-76 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031681", "l": "G-protein beta-subunit binding", "d": ["Binding to a G-protein beta subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69599", "l": "AMP + inosine <=> adenosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30641", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+) => (R)-glycerate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867344", "l": "OMA1 hydrolyses OPA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69574", "l": "2'-deoxyinosine + IMP => dIMP + inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39849", "l": "a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+) => a 2-acylglycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726949", "l": "PTGIR binds PTGIR agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10725", "l": "GDP-6-deoxy-alpha-D-talose + NADP(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430347", "l": "MigFilin associates with Filamin and F-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693111", "l": "RHOF auto-activates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31874", "l": "(S)-2,3-epoxysqualene <=> alpha-seco-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46762", "l": "4-methyl-5-nitrocatechol + NAD(+) + nitrite => 2,4-dinitrotoluene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74730", "l": "Insulin degradation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42645", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] => diphosphate + holo-[malonate decarboxylase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030779", "l": "10-hydroxydihydrosanguinarine 10-O-methyltransferase activity", "d": ["Catalysis of the reaction: 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydrochelirubine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790036", "l": "Expression of STAT3-upregulated nuclear proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362522", "l": "ALDHs oxidise atRAL to atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050285", "l": "sinapine esterase activity", "d": ["Catalysis of the reaction: O-sinapoylcholine + H2O = choline + H+ + sinapate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36696", "l": "dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid => desmethyldescarbamoylnovobiocin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54389", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34105", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003846", "l": "2-acylglycerol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202248", "l": "Phosphorylation of PLC-gamma1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047280", "l": "nicotinamide phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111912", "l": "CaMK4 phosphorylates CREB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35650", "l": "ATP + GTP <=> 3',3'-cGAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004372", "l": "glycine hydroxymethyltransferase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389532", "l": "PP2A binds CTLA4 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11623", "l": "H2O + L-2-amino-4-chloropent-4-enoate <=> 2-oxopent-4-enoate + chloride + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58642", "l": "a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine => a 5'-end (5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732629", "l": "PPARG binds PPARG agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001080", "l": "chitosan binding", "d": ["Binding to chitosan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654573", "l": "Activated FGFR1 binds SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43811", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047706", "l": "biochanin-A reductase activity", "d": ["Catalysis of the reaction: dihydrobiochanin A + NADP+ = biochanin A + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31601", "l": "(Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+) => FMNH2 + NADH + O2 + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74808", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062152", "l": "mRNA (cytidine-5-)-methyltransferase activity", "d": ["Catalysis of the reaction: a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H+ + S-adenosyl-L-homocysteine."]}, {"i": "RHEA:61464", "l": "a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23361", "l": "L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose => alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66813", "l": "5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH => 8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35256", "l": "ATP + H2O + lipid A-core(in) => ADP + H(+) + lipid A-core(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58028", "l": "5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH = a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)", "d": []}, {"i": "EC:2.3.1.295", "l": "\"mycoketide-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58949", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine => 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.-", "l": "\"With incorporation of two atoms of oxygen\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52340", "l": "a long-chain fatty acyl-AMP + holo-[mycocerosate synthase] = AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848606", "l": "PTK6 phosphorylates PXN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389762", "l": "Phosphorylation of PD-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788999", "l": "HV1-mediated H+ transfer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655193", "l": "KIAA0101 double monoubiquitination (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51854", "l": "(9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36914", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9035484", "l": "CysS248-MPST:TXN2 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-398184", "l": "LARG activation by G alpha 12/13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41124", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45356", "l": "H2O + N-(11Z-eicosenoyl)-sphing-4-enine = (11Z)-eicosenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692315", "l": "OX40L binds OX40 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64551", "l": "N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] <=> (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811412", "l": "Active ARF recruits coatomer to the Golgi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41632", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39840", "l": "a 2,3-diacyl-sn-glycerol + an acyl-CoA => a triacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44722", "l": "a 1-acyl-sn-glycerol + H(+) + phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37780", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31727", "l": "FADH2 + O2 + styrene = (2S)-2-phenyloxirane + FAD + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.11", "l": "\"styrene monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25038", "l": "ATP + L-seryl-tRNA(Sec) => ADP + O-phospho-L-seryl-tRNA(Sec)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73508", "l": "7,8-dihydroxyflavone + S-adenosyl-L-methionine => 7-hydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5323526", "l": "FRAT proteins bind GSK3beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13566", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol => 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37919", "l": "(9Z,12Z)-octadecadienoate + O2 = (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42813", "l": "cholesterol + octadecanoyl-CoA => cholesteryl octadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14243", "l": "3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+) => 3-amino-4-hydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46704", "l": "ATP + H(+) + salicylate = 2-hydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59244", "l": "3''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033404", "l": "UUG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UUG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42477", "l": "2,2',3-trihydroxydiphenyl ether + H(+) + O2 => 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70556", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O => L-seryl-[protein] + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48690", "l": "D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl => H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862380", "l": "HSD17B13 binds lipid droplets (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062239", "l": "heterochromatin-nuclear membrane anchor activity", "d": ["Binding to heterochromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54328", "l": "2 H(+) + hexadecanoyl-[ACP] + 2 NADPH = hexadecan-1-ol + holo-[ACP] + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72007", "l": "succinate(in) + urate(out) = succinate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64842", "l": "CoA + phenethyl benzoate => 2-phenylethanol + benzoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18794", "l": "alpha-D-ribose 1-phosphate => D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787820", "l": "IL34 dimer binds CSF1R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-517674", "l": "p-S158,221-HuR binds mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662608", "l": "MT2A binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626928", "l": "CREBBP binds FOXO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10436", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.106", "l": "\"bile-acid 7alpha-dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69440", "l": "3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) = 3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63977", "l": "A + dihydropyriculariol => AH2 + pyriculariol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51031", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 <=> 7-chloroindole-3-pyruvate imine dimer + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74212", "l": "H2O + L-threonyl-tRNA(Lys) => L-threonine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400382", "l": "CSNK1E,CSNK1D phosphorylate CRY and PER proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74613", "l": "UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-glucosamine(in) => UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-glucosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69580", "l": "dGMP + inosine = 2'-deoxyguanosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50249", "l": "ATP + D-ribose 5-phosphate + H(+) => ADP-D-ribose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004664", "l": "prephenate dehydratase activity", "d": ["Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13615", "l": "beta-D-fructose 1,6-bisphosphate + H(+) + phosphate => beta-D-fructose 6-phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418904", "l": "A1 and A3 receptors bind adenosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65584", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] = 8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19579", "l": "H(+) + luteolin 7-O-beta-D-glucoside + UDP => luteolin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784735", "l": "PCSK9:LDLR bind to Clathrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38571", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.80", "l": "\"long-chain acyl-[acyl-carrier-protein] reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031751", "l": "D4 dopamine receptor binding", "d": ["Binding to a D4 dopamine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27643", "l": "adenosine + phosphate => adenine + alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61771", "l": "rebaudioside A + UDP-alpha-D-glucose <=> H(+) + rebaudioside D + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327746", "l": "FN1 aggregation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75466", "l": "choline(out) + n H(+)(in) <=> choline(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729704", "l": "SARS-CoV-2 3CLpro dimer cleaves TAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45294", "l": "2-glyceryl-prostaglandin H2 + A + H2O => 2-glyceryl-prostaglandin G2 + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2464822", "l": "RDH12 reduces atRAL to atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44743", "l": "27-O-demethylrifamycin SV + S-adenosyl-L-methionine <=> H(+) + rifamycin SV + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75328", "l": "chloride(out) + D-tryptophan(out) + 2 Na(+)(out) => chloride(in) + D-tryptophan(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58339", "l": "a 4-hydroxynonen-1-ol + NADP(+) <=> a 4-hydroxynonenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.56", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163310", "l": "TFAM binds to mitochondrial promoters (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5681980", "l": "ATG12 binds ATG7 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806974", "l": "MET dimers autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9005980", "l": "IL21 binds IL21R:JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762343", "l": "PREDL:ALB dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050606", "l": "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal dehydrogenase activity", "d": ["Catalysis of the reaction: 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP+ = 2-oxo-2H-pyran-4,6-dicarboxylate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32134", "l": "(2S)-ethylmalonyl-CoA + H(+) <=> butanoyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33754", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67738", "l": "aceneuramate => N-acetyl-alpha-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17311", "l": "a phenol + acetate + H(+) => a phenyl acetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814094", "l": "ARL1:GTP binds ARFIP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62219", "l": "isoepoxydon + NADP(+) <=> H(+) + NADPH + phyllostine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71644", "l": "guanosine + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008139", "l": "nuclear localization sequence binding", "d": ["Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352994", "l": "3-phosphoglycerate <=> 2-phosphoglycerate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36613", "l": "(5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate => (3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67785", "l": "2 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419644", "l": "Transphosphorylation of pLIMK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4411383", "l": "NLK phosphorylates TCF/LEF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685319", "l": "CX3 complex formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62365", "l": "FMN-N(5)-peroxide + thymine => (Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202222", "l": "Phosphorylation of PKC theta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.13", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0044823", "l": "retroviral integrase activity", "d": ["Catalysis of the covalent insertion of double-stranded retroviral DNA into host DNA. Proceeds by an endonucleolytic cleavage at each 3'-OH extremity of the viral genome, named 3'-processing, followed by a strand transfer reaction leading to the insertion of the processed viral DNA into the target DNA by a trans-esterification mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30797", "l": "CO2 + glutaryl-CoA + NADH => 2-oxoadipate + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47417", "l": "an NDP-alpha-D-glucose + D-glucose => a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.195", "l": "\"L-ornithine N(5)-monooxygenase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762100", "l": "MYC- and NICD1-dependent NFE2L2 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022175", "l": "MECP2:CREB1 complex binds SLC2A3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448958", "l": "Nuclear translocation of p38 MAPK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38083", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46633", "l": "7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH => 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45454", "l": "ethanolamine + tetradecanoate => H2O + N-tetradecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55660", "l": "2 AH2 + all-trans-beta-carotene + 2 O2 = 2 A + echinenone + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75171", "l": "GTP + NAD(+) = GDP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12509", "l": "loganate + S-adenosyl-L-methionine => loganin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50546", "l": "prostaglandin B2 => prostaglandin C2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31026", "l": "squalene <=> dammara-20,24-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66080", "l": "2-oxopentanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018766", "l": "RHOU binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33353", "l": "CoA + H(+) + N-hexacosanoylsphinganine => hexacosanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5669012", "l": "EDA binds EDAR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9667965", "l": "ANKLE2 binds PP2A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56199", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose <=> H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211959", "l": "CYP3A43 6b-hydroxylates TEST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71395", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate(out) = (5Z,8Z,11Z,14Z)-eicosatetraenoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65575", "l": "(-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102996", "l": "beta,beta digalactosyldiacylglycerol galactosyltransferase activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + a beta,beta digalactosyldiacylglycerol <=> a trigalactosyldiacylglycerol + a 1,2-diacyl-sn-glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685605", "l": "SLAMF7 binds SLAMF7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11821", "l": "diphthamide-[translation elongation factor 2] + NAD(+) => H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033876", "l": "glycochenodeoxycholate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-diphosphate + glycochenodeoxycholate 7-sulfate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448702", "l": "Caspase-1 active tetramer formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49062", "l": "a long chain fatty alcohol + FMN + H(+) + H2O => a long-chain alkane + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43911", "l": "beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O <=> D-galactose + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28328", "l": "D-glucuronate + H(+) + wogonin => H2O + wogonin 7-O-beta-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66231", "l": "asc-C13-CoA + O2 <=> asc-DeltaC13-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18464", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102882", "l": "beta-acoradiene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> beta-acoradiene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0061599", "l": "molybdopterin molybdotransferase activity", "d": ["Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613352", "l": "PLINs bind HSPA8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517674", "l": "p-S158,221-HuR binds mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63853", "l": "dodecanoate + O2 => (2R)-2-hydroperoxydodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.461014234140904", "identifiers": [{"i": "GO:0098960", "l": "postsynaptic neurotransmitter receptor activity", "d": ["Neurotransmitter receptor activity occuring in the postsynaptic membrane during synaptic transmission."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72745", "l": "leukotriene C4(in) => leukotriene C4(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177930", "l": "GAB1 phosphorylation by EGFR kinase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73768", "l": "cyclo(L-tryptophyl-L-alanyl) + dimethylallyl diphosphate => diphosphate + preechinulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50524", "l": "acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22486", "l": "GMP + GTP + 2 H(+) => H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694583", "l": "ABHD4 hydrolyses NAPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62587", "l": "ATP + H2O + L-tyrosine(out) <=> ADP + H(+) + L-tyrosine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25628", "l": "H2O + histamine + O2 <=> H2O2 + imidazole-4-acetaldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29286", "l": "L-alanine(in) + Na(+)(in) <=> L-alanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57607", "l": "a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15761", "l": "L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48781", "l": "ATP + L-erythrulose => ADP + H(+) + L-erythrulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376122", "l": "DSCAM/DSCAML1 homodimerization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205244", "l": "Recruitment of CBL to KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21390", "l": "L-lysine => H2O + L-2-aminohexano-6-lactam", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49441", "l": "(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA => (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37863", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA = 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69421", "l": "H2O2 + iodide => H2O + hypoiodite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69197", "l": "ATP + L-glutamate + L-glutamyl-[beta-tubulin] => ADP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44247", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56693", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 => 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592278", "l": "Autocatalytic activation of proMMP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17771", "l": "betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23399", "l": "H2O + phloretin <=> 1,3,5-trihydroxybenzene + H(+) + phloretate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63546", "l": "kinetensin-(1-8) + L-leucine => H2O + kinetensin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54060", "l": "(2E,6E)-farnesyl diphosphate + H2O = (2Z,6E)-hedycaryol + diphosphate", "d": []}, {"i": "EC:4.2.3.187", "l": "\"(2Z,6E)-hedycaryol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607738", "l": "SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805109", "l": "CDK2 phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2750181", "l": "Syndecan-2 binds CASK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8979071", "l": "KDM6B binds iron (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679266", "l": "Beclin-1 complex translocates to the ER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25719", "l": "H(+) + N,N-dihydroxy-L-trihomomethionine = (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168871", "l": "Fusion of vesicle containing the HA trimer, NA tetramer and M2 tetramer to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047381", "l": "dodecanoyl-[acyl-carrier-protein] hydrolase activity", "d": ["Catalysis of the reaction: H2O + dodecanoyl-[acyl-carrier protein] = dodecanoate + [acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30352", "l": "H(+) + NADH + O2 + pyrrole-2-carboxylate => 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1461995", "l": "pro-defensin alpha 5 is stored in Paneth cell granules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40888", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + octadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197958", "l": "FPGS-2 transforms THF to THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47966", "l": "L-histidyl-[protein] + phosphate => H2O + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44121", "l": "hexadecanoyl-CoA + octadecan-1-ol => CoA + octadecanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186780", "l": "PI3-kinase binds to the active receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13363", "l": "CDP-glycerol + diphosphate => CTP + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019137", "l": "thioglucosidase activity", "d": ["Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36619", "l": "2-hydroxydocosanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22175", "l": "beta-D-fructose 6-phosphate + UDP-alpha-D-glucose <=> H(+) + sucrose 6(F)-phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1362416", "l": "Frataxin binds iron (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10443", "l": "D-glucono-1,5-lactone + H2O <=> D-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640060", "l": "KCNIP3 binds NPAS4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75931", "l": "H2O + taurocyamine = taurine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60290", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47362", "l": "an aliphatic alcohol + decanoate + H(+) => decanoate ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74732", "l": "rhamnetin + S-adenosyl-L-methionine => 7,4'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46791", "l": "a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785438", "l": "NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19708", "l": "CoA + hexadecanal + NAD(+) <=> H(+) + hexadecanoyl-CoA + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54382", "l": "5-hydroxy-alpha-gurjunene + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16205", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] = N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72152", "l": "estrone 3-sulfate(out) + glutarate(in) => estrone 3-sulfate(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867613", "l": "PICALM binds R-SNAREs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9678925", "l": "NR3C1 binds NR3C1 agonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61167", "l": "kaempferol + UDP-beta-L-rhamnose <=> H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25564", "l": "H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18486", "l": "6-acetyl-D-glucose + H2O => acetate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003874", "l": "6-pyruvoyltetrahydropterin synthase activity", "d": ["Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H+ + triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22853", "l": "L-serine + pyruvate => 3-hydroxypyruvate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73254", "l": "cirsimaritin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40205", "l": "14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35295", "l": "adenylyl-molybdopterin + H(+) + tungstate = AMP + H2O + W-molybdopterin cofactor", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69589", "l": "inosine + UMP => IMP + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53454", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983266", "l": "Kinesins bind microtubules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56626", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+) => 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166214", "l": "FA anion flip-flops to the opposite surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8858500", "l": "CLEC10A binds Tn-MUC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705681", "l": "MPP5 binds SARS-CoV-2 E pentamer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295632", "l": "PPA2A dephosphorylates SPRY2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53125", "l": "all-trans-lycopene => delta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018456", "l": "aryl-alcohol dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264435", "l": "Dissociation of the COP1-p53 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35643", "l": "a (2R)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66483", "l": "gypsogenin + UDP-alpha-D-glucose <=> gypsogenin 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420019", "l": "Claudins create paired strands through homophilic and heterophilic cis and trans interactions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17122", "l": "carbamoyl phosphate + L-lysine => H(+) + L-homocitrulline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41481", "l": "an acyl-CoA + episterol => an episterol ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008771", "l": "[citrate (pro-3S)-lyase] ligase activity", "d": ["Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0031821", "l": "G protein-coupled serotonin receptor binding", "d": ["Binding to a metabotropic serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26302", "l": "5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) => (S)-allantoin + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193703", "l": "IKKbeta is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10792", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2", "d": []}, {"i": "EC:4.1.1.21", "l": "\"phosphoribosylaminoimidazole carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672973", "l": "MAP2Ks phosphorylate MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0004526", "l": "ribonuclease P activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42946", "l": "5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(40) in tRNA precursor + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39950", "l": "1,3-diacyl-sn-glycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42698", "l": "NH4(+) + pyruvate + selnoneine thione => H2O + hercynylselenocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913451", "l": "IL3RB is phosphorylated on Ser-585 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22148", "l": "a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] = a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]", "d": []}, {"i": "EC:7.1.1.6", "l": "\"plastoquinol--plastocyanin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002401", "l": "Association of procollagen type XVIII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37007", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69722", "l": "(indol-3-yl)acetate + ATP + H(+) <=> (indol-3-yl)acetyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202947", "l": "Caspase mediated cleavage of APC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15327", "l": "a 1-acyl-sn-glycero-3-phosphate + CoA => an acyl-CoA + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70133", "l": "6-dehydro-28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9612219", "l": "ERBB4s80 binds to SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047392", "l": "CMP-N-acylneuraminate phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + CMP-N-acylneuraminate = N-acylneuraminate + CMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222237", "l": "SMYD2 methylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42500", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) = 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33308", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] => (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28261", "l": "cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate <=> cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39739", "l": "3-hydroxydodecanoate + H(+) + NADPH + O2 = 3,12-dihydroxydodecanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44543", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51551", "l": "(R)-tetrahydropapaverine + S-adenosyl-L-methionine <=> (R)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691167", "l": "CUL1, SKP1, FBXL5 bind (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63299", "l": "an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656211", "l": "MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903231", "l": "mRNA base-pairing translational repressor activity", "d": ["A translation repressor activity that acts by base-pairing with an mRNA. The binding can result in targeting the mRNA for degradation or interfering with mRNA translation, hence resulting in posttranscriptional gene silencing."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62347", "l": "6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate <=> diphosphate + notoamide S", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44672", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640167", "l": "RRAGA,B exchanges GDP for GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211731", "l": "Interaction of PAK-2p34 with RGH10/ PS-GAP results in accumulation of PAK-2p34 in the perinuclear region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52065", "l": "13-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27621", "l": "(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate <=> di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016314", "l": "phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70765", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9650165", "l": "ASIC trimers bind H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66708", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663511", "l": "BIL binds GSTA1, FABP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25242", "l": "(S)-2-ureidoglycine + H2O => (S)-ureidoglycolate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49216", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate", "d": []}, {"i": "EC:3.1.3.103", "l": "\"3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140693", "l": "molecular condensate scaffold activity", "d": ["Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54117", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + pseudolaratriene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247843", "l": "secretion of WNT ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17504", "l": "H2O + polyneuridine aldehyde <=> 16-epivellosimine + CO2 + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23774", "l": "2,3-dihydroxy-p-cumate + H(+) + NADH => (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42943", "l": "cytidine(34) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32634", "l": "erythromycin D + H(+) + NADPH + O2 <=> erythromycin C + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37543", "l": "2-amino-5-chlorophenol + O2 = 2-amino-5-chloromuconate 6-semialdehyde", "d": []}, {"i": "EC:1.13.11.76", "l": "\"2-amino-5-chlorophenol 1,6-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106388", "l": "18S rRNA aminocarboxypropyltransferase activity", "d": ["Catalysis of the reaction: N1-methylpseudouridine in 18S rRNA + S-adenosyl-L-methionine = H+ + N1-methyl-N3-[(3S)-3-amino-3-carboxypropyl]pseudouridine in 18S rRNA + S-methyl-5'-thioadenosine."]}, {"i": "RHEA:63296", "l": "an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41596", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190256", "l": "FGFR1c binds to FGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55151", "l": "a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) <=> a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047072", "l": "2,3-dihydroxybenzoate 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxybenzoate + O2 = 2-carboxy-cis,cis-muconate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55825", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide d => a bacteriochlorophyllide f + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71731", "l": "citrate(out) + tartrate(in) = citrate(in) + tartrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19226", "l": "glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine => 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102332", "l": "fatty-acyl-[acp] elongase/decarboxylase activity", "d": ["Catalysis of the reaction: malonyl-CoA + H+ + a long-chain acyl-[acp] + a reduced electron acceptor = 2 carbon dioxide + coenzyme A + a terminal olefin + a holo-[acyl-carrier protein] + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60334", "l": "H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53708", "l": "(2E)-decenoyl-CoA + NADP(+) = (2E,4Z)-decadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173636", "l": "Formation of classic pathway C5 convertase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044466", "l": "glutaryl-CoA hydrolase activity", "d": ["Catalysis of the reaction: glutaryl-CoA + H2O = CoA + glutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050122", "l": "N-acylhexosamine oxidase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosamine + H2O + O2 = N-acetyl-D-glucosaminate + H2O2 + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21757", "l": "deacetylisoipecoside + H2O => dopamine + secologanin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141310", "l": "FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59993", "l": "H(+) + oxidized [electron-transfer flavoprotein] + phloretate => (E)-4-coumarate + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692134", "l": "Expression of FGF9 in testis differentiation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34799", "l": "2,3-didehydroadipoyl-CoA + acetyl-CoA = 3-oxo-5,6-didehydrosuberyl-CoA + CoA", "d": []}, {"i": "EC:2.3.1.223", "l": "\"3-oxo-5,6-didehydrosuberyl-CoA thiolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21262", "l": "[thioredoxin]-dithiol + L-methionine (R)-S-oxide => [thioredoxin]-disulfide + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71446", "l": "3-O-methyl-L-dopa(out) + L-phenylalanine(in) <=> 3-O-methyl-L-dopa(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693012", "l": "TNFSF15 binds TNFRSF25 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015418", "l": "ABC-type quaternary ammonium compound transporting activity", "d": ["Catalysis of the reaction: ATP + H2O + quaternary ammonium(out) = ADP + H+ + phosphate + quaternary ammonium(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.1", "l": "\"unspecific peroxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65034", "l": "3 a quinol + protoporphyrin IX => 3 a quinone + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110011", "l": "Binding of Grb10 to the insulin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55609", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19081", "l": "1-haloalkane + H2O = a halide anion + a primary alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10963", "l": "(S)-lactate <=> (R)-lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114553", "l": "Activation of conventional Protein Kinase C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39384", "l": "3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14264", "l": "(E)-sinapoyl-CoA + D-glucono-1,5-lactone <=> 6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68553", "l": "NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine => H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141002", "l": "histone H4K16 propionyltransferase activity", "d": ["Catalysis of the reaction: histone H4 L-lysine (position 16) + propionyl-CoA = CoA + H+ + histone H3 N6-propionyl-L-lysyl (position 16)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12406", "l": "H(+) + lactose + UDP => D-glucose + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.130", "l": "\"tetraacyldisaccharide 4'-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0034596", "l": "phosphatidylinositol phosphate 4-phosphatase activity", "d": ["Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9633044", "l": "ESR binds STRN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27369", "l": "acetoin + CoA + NAD(+) = acetaldehyde + acetyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:2.3.1.190", "l": "\"acetoin dehydrogenase system\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047263", "l": "N-acylsphingosine galactosyltransferase activity", "d": ["Catalysis of the reaction: ceramide + UDP-galactose = D-galactosylceramide + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11519", "l": "H2O + succinyl-CoA <=> CoA + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57512", "l": "chlorobenzene + H(+) + NADH + O2 = (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}, {"i": "EC:1.14.12.26", "l": "\"chlorobenzene dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102665", "l": "indole-3-acetyl-glutamate synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-glutamate + ATP <=> H+ + indole-3-acetyl-glutamate + AMP + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68736", "l": "ganoderate TR + O2 + reduced [NADPH--hemoprotein reductase] = ganoderate Jc + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821412", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20717", "l": "H(+) + H2O + S-adenosyl-L-homocysteine => NH4(+) + S-inosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67472", "l": "H2O + succinyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10581", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417898", "l": "P2Y4 receptor can bind to UTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75942", "l": "4-aminobutanoate + L-arginine <=> 4-guanidinobutanoate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685639", "l": "Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018794", "l": "RHOV binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10679", "l": "(2R,3S)-3-isopropylmalate <=> 2-isopropylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9680443", "l": "ROCK1,2 bind ROCKi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47315", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733545", "l": "Bile salts and acids bind ALB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73161", "l": "FMN(in) + NAD(+)(out) => FMN(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983194", "l": "Kinesin-1 is a heterotetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49220", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP = CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate", "d": []}, {"i": "EC:2.7.7.92", "l": "\"3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166387", "l": "The FA anion diffuses away laterally from UCP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.233323709485049", "identifiers": [{"i": "GO:0004713", "l": "protein tyrosine kinase activity", "d": ["Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62051", "l": "an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48473", "l": "ganglioside GT1a + H2O => ganglioside GD1a + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.26", "l": "\"rhodotorulapepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166753", "l": "Conversion of C4 into C4a and C4b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735268", "l": "GATA4 and NKX2-5 bind the HAND1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047062", "l": "trans-acenaphthene-1,2-diol dehydrogenase activity", "d": ["Catalysis of the reaction: (+-)-trans-acenaphthene-1,2-diol + 2 NADP+ = acenaphthene-1,2-dione + 2 H+ + 2 NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373706", "l": "Contactin-1 (CNTN1) binds NOTCH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390649", "l": "CHRM1,3,5 bind acetylcholine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41935", "l": "H2O + hexadecanoyl-[ACP] <=> H(+) + hexadecanoate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173723", "l": "C8 binds C5b:C6:C7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33148", "l": "ATP + daunorubicin(in) + H2O => ADP + daunorubicin(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047614", "l": "aconitate delta-isomerase activity", "d": ["Catalysis of the reaction: trans-aconitate = cis-aconitate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13980", "l": "D-serine <=> NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74654", "l": "CTP + N-acetyl-D-glucosamine <=> CDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50003", "l": "butane + H(+) + NADH + O2 <=> butan-1-ol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59769", "l": "hexadecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32421", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADH => (1S,2R,4R)-neoisodihydrocarveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696271", "l": "RND1 binds effectors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61301", "l": "5-deoxy-D-ribulose 1-phosphate => acetaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17988", "l": "4-(trimethylamino)butanal + H2O + NAD(+) <=> 4-(trimethylamino)butanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23632", "l": "D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27715", "l": "GMP + H2O => guanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805507", "l": "APAF1 binds AVEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983194", "l": "Kinesin-1 is a heterotetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74073", "l": "ADP + an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374896", "l": "Uptake of Noradrenaline (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018325", "l": "ESR1:ESTG binds CXXC5 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008123", "l": "cholesterol 7-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61628", "l": "5-aminopentanal = 1-piperideine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45651", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38803", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004356", "l": "glutamate-ammonia ligase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP + NH3 = L-glutamine + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606883", "l": "CD19 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68985", "l": "a 2'-deoxycytidine in DNA + ATP + H2O + S-adenosyl-L-methionine => a 5-methyl-2'-deoxycytidine in DNA + ADP + 2 H(+) + phosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710294", "l": "GSDMD expression mediated by IRF2, IRF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849102", "l": "SRMS phosphorylates PTK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46511", "l": "NADH + nitrobenzene + O2 <=> catechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32915", "l": "sn-glycero-3-phospho-1D-myo-inositol(out) = sn-glycero-3-phospho-1D-myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71085", "l": "estrone 3-sulfate(in) + 2 Na(+)(in) => estrone 3-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694421", "l": "PP6 dephosphorylates SEC24 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649735", "l": "Intrinsic nucleotide exchange on RAS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53260", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.-", "l": "\"Omega peptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47154", "l": "2-oxoglutarate + 2 H(+) + NADH => 2,5-dioxopentanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44020", "l": "H2O + NAD(+) + octadecanal = 2 H(+) + NADH + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427570", "l": "Group 3 - Selective Cl- transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75856", "l": "Abortive Initiation Before Second Transition (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18198", "l": "N-cyclohexylformamide => cyclohexyl isocyanide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6813740", "l": "GDE1 hydrolyzes GroPIns (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-447130", "l": "Interleukin-23 binds interleukin-23 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68584", "l": "ATP + H2O + L-tryptophan(out) = ADP + H(+) + L-tryptophan(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.373", "l": "\"alpha-(1->2) branching sucrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41117", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701485", "l": "Active ALK binds JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668605", "l": "RAC2:GTP binds NOX2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388814", "l": "Grb2 binds CD28 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17923", "l": "D-xylulose + H(+) + NADH => D-arabinitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69843", "l": "a 5,6-dihydrouridine in RNA + NAD(+) = a uridine in RNA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30336", "l": "CTP + H(+) + H2O => NH4(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174367", "l": "GCL ligates L-Glu to L-Cys (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050039", "l": "lactaldehyde reductase (NADPH) activity", "d": ["Catalysis of the reaction: NADP+ + propane-1,2-diol = (S)-lactaldehyde + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29257", "l": "Ca(2+)(out) + Na(+)(in) => Ca(2+)(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12143", "l": "a 2'-deoxyribonucleoside + ATP <=> a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.25", "l": "\"N-terminal E2 ubiquitin-conjugating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564117", "l": "Collagen type XIV degradation by MMP9,13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034862", "l": "Activated NTRK3 binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54381", "l": "(2E,6E)-farnesyl diphosphate + H2O => 5-hydroxy-alpha-gurjunene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42959", "l": "cytidine(38) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71322", "l": "chloride(out) + L-cysteine(out) + 2 Na(+)(out) <=> chloride(in) + L-cysteine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682769", "l": "LGI2 binds ADAM22,23 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451033", "l": "(S)-Malate <=> Fumarate + H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177926", "l": "Dephosphorylation of PAG by SHP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50730", "l": "4-hydroxyphenylacetonitrile + H2O => (Z)-(4-hydroxyphenyl)acetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009918", "l": "sterol delta7 reductase activity", "d": ["Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23388", "l": "ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.119", "l": "\"hygromycin-B 7''-O-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48844", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46273", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37290", "l": "ATP + H2O + L-alanyl-L-leucine(out) <=> ADP + H(+) + L-alanyl-L-leucine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38293", "l": "(S)-malate + CoA + H(+) => (S)-malyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109858", "l": "MAP2K2 binds MAPK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22326", "l": "leukotriene B4 => H2O + leukotriene A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13866", "l": "GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol => beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626356", "l": "Defective SLC24A5 does not exchange cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70208", "l": "sphinga-4E,14Z-dienine-1-phosphate(in) => sphinga-4E,14Z-dienine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48359", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102266", "l": "tRNA-dihydrouridine20a synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil20a in tRNA + NAD(P) = H+ + a uracil20a in tRNA + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938930", "l": "RUNX1 binds ELF2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25578", "l": "3 H2O2 + protoporphyrin IX => 3 O2 + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13532", "l": "(3S)-citramalate <=> H2O + mesaconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193715", "l": "5beta-cholestan-3alpha,7alpha,24(S)-triol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68914", "l": "AMP + diphosphate + NADP(+) + propanal => ATP + H(+) + NADPH + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16983", "l": "H(+) + maleylacetate + NADH => 3-oxoadipate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28928", "l": "3,4,5-trihydroxybenzoate + O2 => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53587", "l": "NAD(+) + resolvin D2 <=> 7-oxoresolvin D2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54342", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41785", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)/18:0) => CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15473", "l": "flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose = flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.236", "l": "\"flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141409", "l": "Mad1 binds kinetochore (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981539", "l": "C3b binds to cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18614", "l": "4-methoxybenzoate + AH2 + O2 => 4-hydroxybenzoate + A + formaldehyde + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54066", "l": "10-epi-cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39643", "l": "(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH = (18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102081", "l": "homotaurine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: homotaurine + 2-oxoglutarate(2-) <=> 3-sulfopropanal + L-glutamate(1-)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043897", "l": "glucan 1,4-alpha-maltohydrolase activity", "d": ["Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694487", "l": "M protein oligomerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12825", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine = [thioredoxin]-dithiol + H(+) + phosphate + sarcosine", "d": []}, {"i": "EC:1.21.4.3", "l": "\"sarcosine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73966", "l": "(2E,6E)-farnesyl diphosphate <=> aristolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684096", "l": "CDK2 phosphorylates RBBP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44361", "l": "(2S)-2-hydroxy-3,4-dioxopentyl phosphate => 3-hydroxy-2,4-dioxopentyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43849", "l": "[thioredoxin]-dithiol + arsenate + H(+) => [thioredoxin]-disulfide + arsenite + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028598", "l": "Phosphorylation of YAP by LATS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047449", "l": "2-dehydro-3-deoxy-L-arabinonate dehydratase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033977", "l": "2-haloacid dehalogenase (configuration-retaining) activity", "d": ["Catalysis of the reactions: (S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193964", "l": "CYP21A2 21-hydroxylates PROG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5433066", "l": "Unknown NAT transfers COCH3 to AFXBO-C, AFNBO-C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002401", "l": "Association of procollagen type XVIII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379387", "l": "COMT transfers Met to DA to form 3MT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578965", "l": "TNRC6A binds AGO2:miRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102320", "l": "1,8-cineole 2-exo-monooxygenase activity", "d": ["Catalysis of the reaction: 1,8-cineole + NADPH + H+ + O2 <=> 2-exo-hydroxy-1,8-cineole + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30026", "l": "L-alanine + pyridoxal 5'-phosphate <=> pyridoxamine 5'-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917693", "l": "ESCRT Disassembly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8963915", "l": "1,25(OH)2D binds VDR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53970", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP] => apo-[BtrI ACP] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10078", "l": "beta-D-galactose + D-glucose => H2O + lactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173725", "l": "C9 binds C5b:C6:C7:C8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24384", "l": "ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)", "d": []}, {"i": "EC:6.3.5.1", "l": "\"NAD(+) synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849094", "l": "ARHGAP35 binds RASA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2172433", "l": "Collagen type XIX degradation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29841", "l": "2-dehydro-L-idonate + H(+) + NADPH => L-idonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052677", "l": "D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity", "d": ["Catalysis of the reaction: D-arabinitol + NADP+ = D-xylulose + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51878", "l": "desmethylxanthohumol + diphosphate => 2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65428", "l": "deamido-NAD(+)(in) + NAD(+)(out) = deamido-NAD(+)(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419461", "l": "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018607", "l": "1-indanone monooxygenase activity", "d": ["Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3,4-dihydrocoumarin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34800", "l": "2,3-didehydroadipoyl-CoA + acetyl-CoA => 3-oxo-5,6-didehydrosuberyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111962", "l": "PDE4A,C,D hydrolyse cAMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22764", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate", "d": []}, {"i": "EC:3.1.3.36", "l": "\"phosphoinositide 5-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11084", "l": "3-dehydro-L-gulonate + H(+) = CO2 + L-xylulose", "d": []}, {"i": "EC:4.1.1.34", "l": "\"dehydro-L-gulonate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23769", "l": "a fatty acyl-CoA + sphing-4-enine => an N-acylsphing-4-enine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18630", "l": "ATP + NAD(+) => ADP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018656", "l": "phenanthrene 3,4-monooxygenase activity", "d": ["Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-3,4-oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668735", "l": "RAC1:GTP binds NOX3 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6790038", "l": "Expression of HSP90B1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20820", "l": "choline sulfate + H2O = choline + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.6", "l": "\"choline-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373732", "l": "Nephrin trans-homophilic interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57936", "l": "H2O + isopyridoxal + NAD(+) = 5-pyridoxate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.102", "l": "\"isopyridoxal dehydrogenase (5-pyridoxate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38765", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31362", "l": "FMNH2 + nitrilotriacetate + O2 <=> ammoniodiacetate + FMN + glyoxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48896", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a = 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0016728", "l": "oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62782", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709454", "l": "EPOR binds EPOR agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44156", "l": "1D-myo-inositol 5-phosphate + H2O = myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209098", "l": "p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73997", "l": "(S)-(+)-nephthenol + diphosphate => geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53736", "l": "a 2-halobenzoate + H(+) + NADH + O2 = a halide anion + catechol + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14022", "l": "AH2 + ecdysone + O2 => 20-hydroxyecdysone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028260", "l": "δ12-PGJ3 spontaneously dehydrates to  15d-PGJ3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655284", "l": "Activated FGFR4 mutants phosphorylate FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13466", "l": "(S)-2,3-diaminopropanoate + oxalyl-CoA => CoA + N(3)-oxalyl-L-2,3-diaminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0004448", "l": "isocitrate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27372", "l": "acetoin + CoA + NAD(+) <=> acetaldehyde + acetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63614", "l": "prunetin-5-O-beta-D-glucuronide + UDP => prunetin + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11593", "l": "dihydromonacolin L-[lovastatin nonaketide synthase] + H2O => dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29076", "l": "formate(out) + 2 H(+)(in) + ubiquinone-8 => CO2(out) + H(+)(out) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.40", "l": "\"D-mannitol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54474", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate => 1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350651", "l": "Caspase-mediated cleavage of MASK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9696267", "l": "RND3 binds GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69180", "l": "ADP + thiamine diphosphate = AMP + thiamine triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10232", "l": "5,6-dihydrouridine 5'-monophosphate + diphosphate = 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate", "d": []}, {"i": "EC:2.4.2.20", "l": "\"dioxotetrahydropyrimidine phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622357", "l": "PIKE-L interaction with UNC5B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64553", "l": "(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase] => 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734713", "l": "ORC6 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433451", "l": "JAK2 binds to p-KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55989", "l": "H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28004", "l": "D-glyceraldehyde 3-phosphate + dihydroxyacetone => beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805740", "l": "SETD8 methylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008798", "l": "beta-aspartyl-peptidase activity", "d": ["Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163669", "l": "Transcriptional activation of pyruvate kinase gene by ChREBP:MLX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35798", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin A + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65624", "l": "hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine = CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953037", "l": "E2F8 forms homodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50187", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864569", "l": "WWOX binds TFAP2C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390595", "l": "Calcium Binds Troponin-C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29631", "l": "D-maltotetraose + H2O = alpha-D-glucose + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30072", "l": "acetyl-CoA + butanoate => acetate + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2214351", "l": "PLK1 phosphorylates GORASP1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66148", "l": "2-phenylethylamine + acetyl-CoA = CoA + H(+) + N-(2-phenylethyl)acetamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33730", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine <=> a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73842", "l": "ATP + H2O + phenol <=> AMP + 2 H(+) + phenyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15716", "l": "a beta-D-galactoside + acetyl-CoA <=> a 6-acetyl-beta-D-galactoside + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.23", "l": "\"mucorpepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205118", "l": "TRAF6 polyubiquitinates NRIF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689085", "l": "ATXN3 binds polyUb-PARK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.481603666032214", "identifiers": [{"i": "GO:0008641", "l": "ubiquitin-like modifier activating enzyme activity", "d": ["Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68066", "l": "a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30183", "l": "L-galactonate + NAD(+) = H(+) + keto-D-tagaturonate + NADH", "d": []}, {"i": "EC:1.1.1.414", "l": "\"L-galactonate 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37751", "l": "2-methyl-trans-aconitate = 2-methyl-cis-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73511", "l": "2-oxoglutarate + 8-hydroxysalvigenin + O2 = CO2 + formaldehyde + pilosin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16518", "l": "(R)-1-aminopropan-2-ol + NAD(+) => aminoacetone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15236", "l": "Fe(III)-[cytochrome c] + H2O + nitric oxide <=> Fe(II)-[cytochrome c] + 2 H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11572", "l": "FAD + H(+) + H2O + lithocholate = chenodeoxycholate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69825", "l": "(22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016170", "l": "interleukin-15 receptor binding", "d": ["Binding to an interleukin-15 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111879", "l": "PIP2 hydrolysis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73287", "l": "(2S)-naringenin + S-adenosyl-L-methionine = (2S)-naringenin 4'-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102052", "l": "indole-3-acetyl-proline synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-proline + ATP(4-) <=> H+ + indole-3-acetyl-proline + AMP(2-) + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31108", "l": "3-phenylpyruvate + O2 => (2-hydroxyphenyl)acetate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22839", "l": "a fatty acyl-[ACP] + H(+) + malonyl-[ACP] <=> a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56877", "l": "(R)-N-acetyl-1-phenylethylamine + H2O => (R)-1-phenylethylamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201783", "l": "Inactive catalytic PP2B is activated by the binding of calmodulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58178", "l": "all-trans-lycopaoctaene + 2 diphosphate + NADP(+) => 2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64418", "l": "D-xylono-1,4-lactone + H(+) + NADPH => D-xylofuranose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901707", "l": "leptomycin B binding", "d": ["Binding to leptomycin B."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58999", "l": "H2O + indole-3-carbaldehyde + O2 <=> H(+) + H2O2 + indole-3-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60124", "l": "pre-sodorifen diphosphate = diphosphate + sodorifen", "d": []}, {"i": "EC:4.2.3.205", "l": "\"sodorifen synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57419", "l": "H2O + L-asparaginyl-[protein] <=> L-aspartyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40186", "l": "O2 + tetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034868", "l": "2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA = 2,4,4-trimethyl-3-oxopentanoyl-CoA + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34600", "l": "15-methylhexadecasphinganine + NADP(+) => 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997237", "l": "SH2B proteins bind JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0015277", "l": "kainate selective glutamate receptor activity", "d": ["An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858346", "l": "AMHR2 binds AMH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22884", "l": "glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine", "d": []}, {"i": "EC:2.6.1.73", "l": "\"methionine--glyoxylate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693061", "l": "STAMBP binds STAM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29273", "l": "a menaquinone + H2O + trimethylamine => a menaquinol + H(+) + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34146", "l": "cannabinerolate + O2 <=> Delta(9)-tetrahydrocannabinolate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75197", "l": "5-hydroxy-2,4-dioxopentanoate + H(+) + NADH => 2-dehydro-3-deoxy-D-arabinonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10834", "l": "6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+) => an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933523", "l": "Dimerzation of procaspase-8, procaspase-10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0016756", "l": "glutathione gamma-glutamylcysteinyltransferase activity", "d": ["Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67063", "l": "asnovolin I + S-adenosyl-L-methionine <=> asnovolin K + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018452", "l": "5-exo-hydroxycamphor dehydrogenase activity", "d": ["Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507868", "l": "Aquaporins passively transport water into cells (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53236", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] = (24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690493", "l": "RHOB binds effectors on endosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57669", "l": "alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31009", "l": "beta-amyrin => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247839", "l": "Retromer associates with WLS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19432", "l": "[beta-adrenergic receptor] + ATP <=> [beta-adrenergic receptor]-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.84", "l": "\"Ste24 endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004069", "l": "L-aspartate:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909738", "l": "SHP1 and SHP2 bind the common beta chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909732", "l": "Phosphorylation of STAT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58554", "l": "(16R)-deshydroxymethyl-stemmadenine + formate => 15alpha-stemmadenine intermediate II + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26044", "l": "acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-9-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928597", "l": "EPH:EFN dimers tetramerise (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37348", "l": "(R)-lactate + ATP + D-alanine => ADP + D-alanyl-(R)-lactate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61306", "l": "H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP => N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769042", "l": "NPAS4 stimulates IQSEC3 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24635", "l": "2 H2O + 3 NADP(+) + NH4(+) <=> 5 H(+) + 3 NADPH + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39860", "l": "1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol => a triacyl-sn-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.958976004066542", "identifiers": [{"i": "GO:0090599", "l": "alpha-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52740", "l": "glyphosate + H2O + O2 = aminomethylphosphonate + glyoxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74028", "l": "L-alanine(in) + L-threonine(out) => L-alanine(out) + L-threonine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18532", "l": "3-methylbutanol + NAD(+) <=> 3-methylbutanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30986", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] <=> beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65458", "l": "2-methylbutyl acetate + CoA => 2-methylbutan-1-ol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222093", "l": "BRD7 binds TP53 and EP300 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24179", "l": "[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374675", "l": "L1 dimer binds Ankyrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042134", "l": "rRNA primary transcript binding", "d": ["Binding to an unprocessed ribosomal RNA transcript."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32624", "l": "L-threo-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110164", "l": "SMUG1 glycosylase mediated recognition and binding of uracil in DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165033", "l": "Multimerization of Rev (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989764", "l": "Expression of CYP1A1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41818", "l": "ganglioside GD2 (d18:1(4E)) + H(+) + UDP => ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201608", "l": "Caspase-mediated cleavage of alpha adducin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11727", "l": "[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite <=> 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15347", "l": "AMP + diphosphate + H(+) + L-tyrosyl-L-arginine => ATP + L-arginine + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1254291", "l": "ERBB4s80 binds STAT5A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202137", "l": "AKT1 binds eNOS complex via HSP90 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11606", "l": "[(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29608", "l": "H2O + NAD(+) + nitrous oxide => H(+) + NADH + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59342", "l": "1'-hydroxy-demethylspheroidene + AH2 => 1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36143", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADPH = hexadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72769", "l": "7-methylmellein + 3 CO2 + 5 CoA + 4 H2O + 5 NADP(+) => acetyl-CoA + 9 H(+) + 4 malonyl-CoA + 5 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18471", "l": "an N(2)-acyl-L-glutamine + CoA + H(+) => an acyl-CoA + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416516", "l": "GRK2 sequesters activated Gq (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029454", "l": "Autophosphorylation of PAK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9650858", "l": "Meglitinides bind ABCC8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983709", "l": "LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654603", "l": "Activated FGFR2 binds FRS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132278", "l": "Cleavage of C5 by C5 convertases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806412", "l": "TP53 and AP-1 bind the MSH2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877385", "l": "RUNX1 binds intron 1 of IL2RA (CD25) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22203", "l": "S-adenosyl-L-methionine + trans-aconitate <=> (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65297", "l": "(2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67226", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA => (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008804", "l": "carbamate kinase activity", "d": ["Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50191", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53672", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797553", "l": "Protein 4.1 binds CASK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211239", "l": "Association of DFF40 with chromatin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20405", "l": "H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + acetate", "d": []}, {"i": "EC:3.5.1.47", "l": "\"N-acetyldiaminopimelate deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008836", "l": "diaminopimelate decarboxylase activity", "d": ["Catalysis of the reaction: meso-2,6-diaminopimelate + H+ = L-lysine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692867", "l": "HRH3 binds pitosilant (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57654", "l": "CMP + ganglioside GM1alpha + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15690", "l": "H(+) + L-2,4-diaminobutanoate => CO2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209361", "l": "STAT92E binds to phosphorylated HOP and phosphorylated DOME (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220978", "l": "FBXW7 WD mutants do not bind NICD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34547", "l": "ATP + cob(II)yrinate + H2O + L-glutamine = ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52077", "l": "13-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22466", "l": "2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase] => L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295599", "l": "SPRY2 translocates to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350769", "l": "trans-Golgi Network Coat Activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030563", "l": "snRNA 2'-O-ribose methylation guide activity", "d": ["Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110498", "l": "DTOR is positively regulated by DRheb-GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49786", "l": "CoA + H(+) + taurochenodeoxycholate => chenodeoxycholoyl-CoA + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050620", "l": "phycocyanobilin:ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31270", "l": "6-hydroxyhexanoate + NADP(+) <=> 6-oxohexanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68422", "l": "(2R,3S)-iso(homo)3citrate => cis-(homo)3aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381608", "l": "cAMP activates EPAC2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45815", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA <=> a very-long-chain (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689000", "l": "AADAC deacetylates PHEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64979", "l": "8-oxo-dGTP + 2 H2O <=> 8-oxo-dGMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74113", "l": "H2O + NAD(+) + taurine => H(+) + hypotaurine + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53569", "l": "12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66735", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in) <=> ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694433", "l": "MIA2 binds PREB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43015", "l": "L-homocysteine <=> 2-aminobut-2-enoate + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73800", "l": "SAICAR => AICAR + Fumarate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62277", "l": "3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine => 6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610723", "l": "GLI proteins bind SUFU (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707516", "l": "FeHM dissociates from MetHb (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34677", "l": "CMP-N,N-diacetyllegionaminate + diphosphate => CTP + N,N-diacetyllegionaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473596", "l": "Collagen type I degradation by MMP15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70273", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445714", "l": "Aquaporin-3 passively transports water out of cell (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933533", "l": "Dimerization of p-IRF7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30999", "l": "(S)-2,3-epoxysqualene = cucurbitadienol", "d": []}, {"i": "EC:5.4.99.33", "l": "\"cucurbitadienol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21828", "l": "H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.7.7.2", "l": "\"ferredoxin--nitrate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508513", "l": "PTK2B binds JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41422", "l": "CO2 + grixazone B + 4 H2O => 2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390598", "l": "Myosin Binds ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59817", "l": "a long-chain fatty acyl-CoA + a sterol => a sterol ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58237", "l": "L-tyrosyl-[protein] + NAD(+) => H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199299", "l": "AKT phosphorylates FOXO transcription factors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297444", "l": "Binding of cAMP to HCN channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113429", "l": "Elongating transcript encounters a lesion in the template (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24912", "l": "2-aminobut-2-enoate + L-cysteine => L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54237", "l": "1,2-didecanoyl-sn-glycerol + CDP-choline => 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617446", "l": "HOXD1 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65050", "l": "4-acetoxybenzaldehyde + H(+) + NADH => 4-acetoxybenzyl alcohol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59306", "l": "adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+) => 3'-phosphoadenylyl sulfate + firefly L-luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73643", "l": "CTP(out) + IDP(in) = CTP(in) + IDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660822", "l": "ATP binds P2RX4,7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22583", "l": "(S)-4-hydroxy-2-oxopentanoate <=> (2Z)-2-hydroxypenta-2,4-dienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222128", "l": "NOC2L binds TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55318", "l": "4 H(+) + 3 NADH + sulfite => 3 H2O + hydrogen sulfide + 3 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29925", "l": "ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75418", "l": "H2O + N-methylmyosmine <=> pseudooxynicotine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31805", "l": "2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP => H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36849", "l": "AMP + FMN-L-threonyl-[protein] + H(+) => FAD + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.70", "l": "\"aculeacin-A deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51861", "l": "(2E)-geranyl diphosphate + umbelliferone => 8-geranylumbelliferone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28510", "l": "arbutin 6-phosphate + H2O = beta-D-glucose 6-phosphate + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760510", "l": "LARP1 binds SARS-CoV-2 RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52203", "l": "1-aci-nitro-2-(phenyl)ethane + glutathione <=> (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71868", "l": "glycodeoxycholate(out) => glycodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683831", "l": "CCDC59 binds TTF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39627", "l": "(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA = (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952371", "l": "MDM2 binds RUNX3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16967", "l": "beta-myrcene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696605", "l": "USP12, USP26 deubiquitinate AR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64335", "l": "ATP + CoA + nicotinate <=> AMP + diphosphate + nicotinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49935", "l": "(3E,5Z)-octadienoyl-CoA <=> (2E,5Z)-octadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64992", "l": "acetyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20242", "l": "nicotinate + S-adenosyl-L-methionine => N-methylnicotinate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193668", "l": "p75NTR and RHOA-GDI interact (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848077", "l": "PTK6 phosphorylates STAP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74495", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B = yaequinolone C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9006873", "l": "IL21 receptor STAT binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24678", "l": "5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O", "d": []}, {"i": "EC:4.2.1.147", "l": "\"5,6,7,8-tetrahydromethanopterin hydro-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32017", "l": "(-)-delta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174445", "l": "RPA binds to the Flap on the C-strand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20994", "l": "16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine => 16-hydroxytabersonine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030408", "l": "glycine formimidoyltransferase activity", "d": ["Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169468", "l": "MCM2-7 mediated fork unwinding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35234", "l": "rifampicin(in) <=> rifampicin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73718", "l": "UBF-1 Binds rDNA Promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17451", "l": "3-linalylflaviolin + diphosphate => (2E)-geranyl diphosphate + flaviolin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706364", "l": "Internalization of ubiquitinated FLT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9726621", "l": "PGR binds PGR antagonists (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12830", "l": "(2S,3S)-3-methyl-L-aspartate => mesaconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197958", "l": "FPGS-2 transforms THF to THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47809", "l": "epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3076905", "l": "Extracellular BTD hydrolyses BCTN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688786", "l": "ATXN3 binds RAD23 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21356", "l": "L-arabinitol + NAD(+) = H(+) + L-ribulose + NADH", "d": []}, {"i": "EC:1.1.1.13", "l": "\"L-arabinitol 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62349", "l": "H(+) + NADPH + notoamide E + O2 => H2O + NADP(+) + notoamide C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730899", "l": "Oligomerization of BCL10 and MALT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72718", "l": "(R)-dihydrolipoate + ATP + H(+) <=> (R)-N(6)-dihydrolipoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19177", "l": "L-lysine = (3S)-3,6-diaminohexanoate", "d": []}, {"i": "EC:5.4.3.2", "l": "\"lysine 2,3-aminomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781905", "l": "ZRANB1 binds APC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46550", "l": "2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine => a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37040", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 => 5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21158", "l": "(R)-glycerate + phosphate => (2R)-2-phosphoglycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867344", "l": "OMA1 hydrolyses OPA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30741", "l": "myo-inositol + phosphate => 1D-myo-inositol 3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30997", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B => O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17049", "l": "3-demethylubiquinol-9 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11034", "l": "3-chloro-cis,cis-muconate + H(+) => (2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56468", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 = (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O", "d": []}, {"i": "EC:1.14.19.57", "l": "\"1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] brominase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805640", "l": "AKT phosphorylates KAT6A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030778", "l": "columbamine O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + H+ + palmatine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71333", "l": "chloride(in) + L-phenylalanine(in) + 2 Na(+)(in) => chloride(out) + L-phenylalanine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070698", "l": "type I activin receptor binding", "d": ["Binding to a type I activin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75878", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30871", "l": "2-deoxy-D-ribose + ATP = 2-deoxy-D-ribose 5-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.229", "l": "\"deoxyribokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033430", "l": "CGC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CGC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49856", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60838", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate => a 5'-end diphospho-adenosine in mRNA + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75657", "l": "(8R)-hydroperoxy-(9Z)-octadecenoate => (9Z)-octadecenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68960", "l": "DNA polymerase epsilon binds at the origin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37187", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20522", "l": "(R)-3-hydroxybutanoate + NAD(+) => acetoacetate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964619", "l": "PAK1 binds ARHGEF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18272", "l": "ethyl (S)-3-hydroxyhexanoate + NADP(+) <=> ethyl 3-oxohexanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051108", "l": "carnitine-CoA ligase activity", "d": ["Catalysis of the reaction: D-carnitine + CoA + ATP = AMP + diphosphate + D-carnitinyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396083", "l": "Laminins bind galactosyl sulfatide and related sulfated glycolipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796691", "l": "SPATA2 links CYLD to LUBAC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12115", "l": "indole-3-pyruvate + S-adenosyl-L-methionine <=> (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19909", "l": "(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": []}, {"i": "EC:1.1.2.3", "l": "\"L-lactate dehydrogenase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683792", "l": "p-T68-CHEK2 autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71368", "l": "epiandrosterone 3-sulfate(out) + 2 Na(+)(out) => epiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29837", "l": "D-galactonate(out) + H(+)(out) => D-galactonate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102509", "l": "cyanidin 3,5-diglucoside glucosidase activity", "d": ["Catalysis of the reaction: cyanin betaine + H2O <=> cyanidin 3-O-beta-D-glucoside betaine + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45401", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051118", "l": "glucan endo-1,3-alpha-glucosidase activity", "d": ["Catalysis of the endohydrolysis of (1->3)-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62292", "l": "(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) = 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62761", "l": "4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848124", "l": "PTK6 phosphorylates STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67417", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73881", "l": "histamine(in) => histamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52419", "l": "3-dehydro-4-O-phospho-D-erythronate + H(+) <=> CO2 + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433711", "l": "Cis-homodimerization of nectins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65951", "l": "a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2 <=> A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54812", "l": "(+)-7-isojasmonate + ATP + L-isoleucine = AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14657", "l": "aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate", "d": []}, {"i": "EC:5.3.1.6", "l": "\"ribose-5-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60315", "l": "L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77608", "l": "Binding of A1CF to stem-looped RNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662986", "l": "MT2A binds copper (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62625", "l": "[glutaredoxin]-dithiol + a hydroperoxide => [glutaredoxin]-disulfide + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.123", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18542", "l": "10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine => dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40239", "l": "ATP + CoA + dodecanedioate = AMP + diphosphate + dodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192010", "l": "5beta-cholestan-3alpha, 7alpha, 12alpha-triol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65959", "l": "ATP + estrone 3-sulfate(out) + H2O <=> ADP + estrone 3-sulfate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20454", "l": "scopoletin + UDP-alpha-D-glucose => H(+) + scopolin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41219", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592240", "l": "Formation of NRF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011748", "l": "IL9R binds JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57520", "l": "15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23808", "l": "(S)-scoulerine + S-adenosyl-L-methionine = (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.117", "l": "\"(S)-scoulerine 9-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192051", "l": "CYP7A1 7-hydroxylates CHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32713", "l": "a 3-oxoacyl-CoA + H(+) + NADH => a (3R)-3-hydroxyacyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64231", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954056", "l": "E2F6 binds TFDP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69053", "l": "RFC binding displaces Pol Alpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72940", "l": "2 Na(+)(out) + propanoate(out) => 2 Na(+)(in) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731081", "l": "Syndecan-1 binds Integrin alphaVBeta5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10623", "l": "(E)-cinnamaldehyde + CoA + NADP(+) <=> (E)-cinnamoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203611", "l": "N-myristoylation of eNOS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23778", "l": "4-phospho-L-aspartate + ADP => ATP + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797090", "l": "CCNK binds CDK12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57724", "l": "H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) + pyruvate", "d": []}, {"i": "EC:7.2.4.2", "l": "\"oxaloacetate decarboxylase (Na(+) extruding)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.110", "l": "\"sterigmatocystin 8-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61990", "l": "5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008445", "l": "D-aspartate oxidase activity", "d": ["Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72757", "l": "3',3',3'-c-tri-AMP + 3 diphosphate => 3 ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2002466", "l": "Formation of allysine by LOX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.4.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28697", "l": "hydrogencarbonate(out) => hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60459", "l": "ATP + UTP <=> 3',3'-cUAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45639", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34383", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose = beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14929", "l": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18354", "l": "ATP + H2O + K(+)(out) + Na(+)(in) => ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34371", "l": "H2O + indole-3-acetamide = (indol-3-yl)acetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827995", "l": "Expression of NANOS3 in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27458", "l": "3-iodo-L-tyrosine + iodide + NADP(+) => 3,5-diiodo-L-tyrosine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912369", "l": "NOTCH precursor cleaved to form mature NOTCH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871260", "l": "YAP1 binds TEAD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18492", "l": "cyanate + H(+) + hydrogencarbonate <=> carbamate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13700", "l": "ATP + D-ribose <=> ADP + D-ribose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37473", "l": "CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine => 3-methylbutanoyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24079", "l": "a 3beta-hydroxy-Delta(5)-steroid + NAD(+) <=> a 3-oxo-Delta(5)-steroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51940", "l": "(1E,2S)-2-methylbutanal oxime = (1Z,2S)-2-methylbutanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36459", "l": "glycyl-L-proline + H2O = glycine + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663122", "l": "p-BMAL1:p-CLOCK,NPAS2 binds NAMPT gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.1", "l": "\"carboxypeptidase A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53309", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29611", "l": "H2O + NADP(+) + nitrous oxide = H(+) + NADPH + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62544", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabagenin = dihydroouabagenin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24056", "l": "a myo-inositol phosphate + H2O = myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66204", "l": "heptanoyl-CoA + O2 = (2E)-heptenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32850", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052892", "l": "aromatic (S)-hydroxynitrile lyase activity", "d": ["Catalysis of the reaction: an aromatic (S)-hydroxynitrile = an aromatic aldehyde + cyanide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.50", "l": "\"V-cath endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199935", "l": "MSK1 activates CREB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870461", "l": "RABGGTA and RABGGTB bind (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707594", "l": "Hemes bind LY96 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59067", "l": "demethylluteothin + S-adenosyl-L-methionine <=> luteothin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937989", "l": "RUNX1 binds PRC1 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879907", "l": "Tyrosine kinases phosphorylate the receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047190", "l": "2-acylglycerophosphocholine O-acyltransferase activity", "d": ["Catalysis of the reaction: 2-acyl-sn-glycero-3-phosphocholine + acyl-CoA = 1,2-diacyl-sn-glycero-3-phosphocholine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675194", "l": "Activated MAPK phosphorylates RAF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33043", "l": "(1R,4R)-camphor + H(+) + NADPH + O2 = (+)-6-exo-hydroxycamphor + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.161", "l": "\"(+)-camphor 6-exo-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170978", "l": "p-FRS2:CRKL binds C3G (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41523", "l": "menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17371", "l": "2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate => glycyrrhizin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63353", "l": "2 H(+) + O2 + octadecanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] => (9Z)-octadecenoyl-CoA + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35806", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O <=> 7,8-dihydroneopterin 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73503", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine = 3',4,7-trihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25835", "l": "1D-chiro-inositol + NAD(+) <=> H(+) + NADH + scyllo-inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34790", "l": "a 3beta-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-996727", "l": "REST recruits the BHC complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62855", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48441", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71802", "l": "Ca(2+)(in) + H(+)(out) <=> Ca(2+)(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.1", "l": "\"microtubule-severing ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67870", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706393", "l": "RHOBTB3 binds ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38191", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29185", "l": "2 H(+) + menaquinone-8 + 2 superoxide => menaquinol-8 + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11255", "l": "H(+) + hydroxylamine + L-asparagine <=> beta-L-aspartylhydroxamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1370500", "l": "PRLR binds SCF beta-TrCP complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.253913141376358", "identifiers": [{"i": "GO:0019205", "l": "nucleobase-containing compound kinase activity", "d": ["Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852013", "l": "BTNL8 binds resting T cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28453", "l": "N(6)-(D-psicosyl)-L-lysine(in) <=> N(6)-(D-psicosyl)-L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66766", "l": "ADP + folate(out) + H(+) + phosphate => ATP + folate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32674", "l": "ATP + UDP-N-acetyl-alpha-D-glucosamine <=> ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31553", "l": "15-cis-4,4'-diapophytoene + diphosphate => presqualene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41283", "l": "H2O + N-tetracosanoyl-sphing-4-enine = sphing-4-enine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39202", "l": "(3R)-hydroxytetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50553", "l": "prostaglandin C1 => prostaglandin B1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32685", "l": "2,5-dicarboxyfuran + 2 H(+) + 3 H2O2 => 5-hydroxymethylfurfural + 2 H2O + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28041", "l": "[thioredoxin]-disulfide + dCDP + H2O <=> [thioredoxin]-dithiol + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139898", "l": "Caspase-8 activates BID by cleavage (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50210", "l": "cortisone + H(+) + NADH => cortisol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43687", "l": "ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate <=> AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982637", "l": "Opsins binds G alpha-t (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68414", "l": "2 H(+) + L-glutamate + NADPH => H2O + L-glutamate 5-semialdehyde + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56720", "l": "2 Fe(III)-[cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate = 2 Fe(II)-[cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-378952", "l": "Thyrotropin is a heterodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75436", "l": "32-oxoeburicol + O2 + reduced [NADPH--hemoprotein reductase] => 14-demethyleburicol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45635", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16295", "l": "(2S)-2-isopropylmalate => 2-isopropylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30665", "l": "hapalindole H => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8962050", "l": "TYMS gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873918", "l": "Transphosphorylation of JAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050635", "l": "acridone synthase activity", "d": ["Catalysis of the reaction: N-methylanthranilyl-CoA + 3 H+ + 3 malonyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48175", "l": "ganglioside GM2 + H2O <=> N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194678", "l": "CYP51A1 demethylates LNSOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.369838362782886", "identifiers": [{"i": "GO:0008375", "l": "acetylglucosaminyltransferase activity", "d": ["Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68958", "l": "H(+) + S-adenosyl-L-homocysteine + scoparone => S-adenosyl-L-methionine + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975853", "l": "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878117", "l": "RUNX3 binds ZFHX3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2395517", "l": "NADPH transfers electrons to FDXR (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046429", "l": "4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity", "d": ["Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60882", "l": "a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+) => a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57773", "l": "3-nitrotoluene + NADH + O2 => 4-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73400", "l": "D-aspartate(in) + sulfate(out) => D-aspartate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.42", "l": "\"FMN reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37768", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944457", "l": "MAF1 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71218", "l": "2 Na(+)(out) + thiocyanate(out) <=> 2 Na(+)(in) + thiocyanate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696822", "l": "AKR1B15 reduces EST17b to E1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62547", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabagenin <=> dihydroouabagenin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112037", "l": "Inactivation of PLC beta (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730899", "l": "Oligomerization of BCL10 and MALT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791057", "l": "Expression of TSPYL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43961", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA => a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58523", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] <=> akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24427", "l": "2 glutathione + L-dehydroascorbate <=> glutathione disulfide + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50880", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol = 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.45", "l": "\"teichoic acid glycerol-phosphate transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57781", "l": "2-chloro-4-nitrotoluene + NADH + O2 => 3-chloro-4-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56138", "l": "2 a phenolic radical donor + 2 H2O => 2 a phenolic donor + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426032", "l": "DAG is metabolized by DAGL to 2-AG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14554", "l": "(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate => 2-oxoglutarate + cephalosporin C", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018750", "l": "biuret amidohydrolase activity", "d": ["Catalysis of the reaction: biuret + H2O = urea + CO2 + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29325", "l": "fumarate(out) + succinate(in) => fumarate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102714", "l": "gibberellin A12,oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 <=> gibberellin A14 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42905", "l": "guanosine(748) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005252", "l": "open rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64271", "l": "emodin anthrone + O2 <=> emodin + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50595", "l": "13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) <=> 15-oxoprostaglandin F1alpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66005", "l": "coenzyme M + methyl-Co(III)-[glycine betaine-specific corrinoid protein] => Co(I)-[glycine betaine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70452", "l": "2-oxoglutarate + an N(1)-ethyl-2'-deoxyadenosine in single-stranded DNA + O2 => a 2'-deoxyadenosine in single-stranded DNA + acetaldehyde + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67596", "l": "heptadecasphing-4-enine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36222", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110171", "l": "MBD4 glycosylase mediated recognition and binding of an uracil opposite to a guanine at CpG sequences (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3221982", "l": "BANP binds TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611751", "l": "β1,2-agonists bind ADRB1,2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20234", "l": "a 7beta-hydroxysteroid + NADP(+) => a 7-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390598", "l": "Myosin Binds ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52686", "l": "H(+) + NADH + pyridoxal => NAD(+) + pyridoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0004102", "l": "choline O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21667", "l": "4-nitrophenyl phosphate + H2O <=> 4-nitrophenol + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11379", "l": "(19E)-geissoschizine + NADP(+) <=> 4,21-dehydrogeissoschizine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023460", "l": "Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140262", "l": "mRNA cap binding complex binding", "d": ["Binding to a mRNA cap binding complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42136", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine = a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75774", "l": "(9Z,12Z,15Z)-octadecatrienoate + H2O <=> (10S)-hydroxy-(12Z,15Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0032394", "l": "MHC class Ib receptor activity", "d": ["Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098872", "l": "G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "d": ["A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067640", "l": "IL6 binds IL6R-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.6", "l": "\"galactonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15592", "l": "2-oxoglutarate + D-4-hydroxyphenylglycine <=> 4-hydroxyphenylglyoxylate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936851", "l": "AHRR binds ARNT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36724", "l": "2-phenylethylamine + A + H2O => 2-phenylacetaldehyde + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36301", "l": "(E)-caffeoyl-CoA + AMP + diphosphate => (E)-caffeate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709098", "l": "DHFR dimer reduces FOLA to DHF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53395", "l": "2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] <=> (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75230", "l": "H2O + L-xylono-1,4-lactone <=> H(+) + L-xylonate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030570", "l": "pectate lyase activity", "d": ["Catalysis of the reaction: a pectate = a pectate + a pectate oligosaccharide with 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate end. This reaction is the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.64", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75326", "l": "chloride(out) + D-leucine(out) + 2 Na(+)(out) <=> chloride(in) + D-leucine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693012", "l": "TNFSF15 binds TNFRSF25 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43188", "l": "S-adenosyl-L-methionine + uridine(2634) in 25S rRNA = H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24155", "l": "adenosine 5'-phosphosulfate + ATP <=> 3'-phosphoadenylyl sulfate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18284", "l": "NAD(+) + succinate <=> fumarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67173", "l": "O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] => formate + 2 H(+) + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23775", "l": "(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) <=> 2,3-dihydroxy-p-cumate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46969", "l": "A + dihydroisopentenyldehydrorhodopin => AH2 + isopentenyldehydrorhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25569", "l": "ATP + beta-D-ribosylnicotinate => ADP + H(+) + nicotinate beta-D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448744", "l": "IL20RA binds IL20RB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38080", "l": "2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA => 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731012", "l": "SARS-CoV-1 3a tetramerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641229", "l": "TLE oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26295", "l": "1'-hydroxyversicolorone + H2O + NADP(+) => (1'S,5'S)-averufin + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69696", "l": "H(+) + menadione + NADH => menadiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009072", "l": "STAT3 phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31209", "l": "(2E)-hexenoyl-CoA + FADH2 => FAD + H(+) + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004478", "l": "methionine adenosyltransferase activity", "d": ["Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682377", "l": "LC3 de-lipidation by ATG4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72602", "l": "N-acetyl-L-aspartyl-L-glutamate(out) <=> N-acetyl-L-aspartyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50486", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418662", "l": "Src activation following P2Y purinoceptor activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40426", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37798", "l": "2 H(+) + 2 NADPH + O2 <=> 2 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936563", "l": "ISGylation of DDX58 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44159", "l": "1D-myo-inositol 5-phosphate + H2O <=> myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29236", "l": "a menaquinone + H(+) + NADH => a menaquinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13447", "l": "(R)-pantothenate + cysteamine => (R)-pantetheine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444100", "l": "PROT mediates L-proline uptake (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69464", "l": "2 [thioredoxin]-dithiol + arsenic triglutathione + H2O + 2 S-adenosyl-L-methionine = 2 [thioredoxin]-disulfide + dimethylarsinous acid + 3 glutathione + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59678", "l": "D-maltotetraono-1,5-lactone + H2O2 => D-maltotetraose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.-", "l": "\"Enzymes altering polypeptide conformation or assembly\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382055", "l": "Grb7 binds to the active PDGF receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0017116", "l": "single-stranded DNA helicase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5591052", "l": "PROCR binds Protein C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.88", "l": "\"trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73948", "l": "(2E)-geranyl diphosphate => (4E,6E)-allo-ocimene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75154", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> diphosphate + neoverrucosan-5beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56089", "l": "CMP-N-acetyl-beta-neuraminate + globoside MSGG => CMP + globoside DSGG + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31842", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22942", "l": "ADP + H(+) + N(omega)-phospho-L-arginine => ATP + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46528", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63218", "l": "7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA => 7-cyano-7-carbaguanosine(15) in tRNA + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56097", "l": "[protein]-C-terminal Gly-Gly + ATP + H(+) => [protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350168", "l": "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30949", "l": "10-epi-gamma-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018856", "l": "benzoyl acetate-CoA ligase activity", "d": ["Catalysis of the reaction: 3-oxo-3-phenylpropionate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58075", "l": "a 4,5-didehydrojasmonate + H(+) + NADPH <=> a jasmonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66256", "l": "ATP + H(+) + IC-asc-C7 = diphosphate + IC-asc-C7-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42694", "l": "[(1->4)-alpha-D-glucosyl](n+2) + phosphate => [(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12352", "l": "L-gulono-1,4-lactone + O2 = H2O2 + L-xylo-hex-3-ulonolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66096", "l": "3-phenylpyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3965450", "l": "DAAM1 recruits PFN1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2186780", "l": "Degradation of Ub-SMAD7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27302", "l": "7-chloro-L-tryptophan + O2 = 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32174", "l": "H(+) + NADPH + O2 + phenylacetyl-CoA <=> 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177922", "l": "EGFR dimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944236", "l": "Association of procollagen type XIV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044684", "l": "dihydromethanopterin reductase activity", "d": ["Catalysis of the reaction: 7,8-dihydromethanopterin + NADPH = 5,6,7,8-tetrahydromethanopterin + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1461993", "l": "pro-HD5 is cleaved by trypsin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62528", "l": "digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydrodigoxin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102650", "l": "cyclo-acetoacetyl-L-tryptophan synthetase activity", "d": ["Catalysis of the reaction: acetoacetyl-ACP + L-tryptophan + ATP <=> cyclo-acetoacetyl-L-tryptophan + AMP + diphosphoric acid + 2 H+ + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36827", "l": "dioscin + 3 H2O = D-glucose + diosgenin + 2 L-rhamnopyranose", "d": []}, {"i": "EC:3.2.1.189", "l": "\"dioscin glycosidase (diosgenin-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14155", "l": "17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP => 17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52277", "l": "(6S)-5,6,7,8-tetrahydrofolate + vanillate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68702", "l": "16alpha,17beta-estriol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 16alpha,17beta-estriol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-114284", "l": "Release of Cytochrome c from mitochondria (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24775", "l": "7(1)-hydroxychlorophyllide a + NADP(+) <=> chlorophyllide b + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390438", "l": "FAR2 reduces PalmCoA to HXOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018747", "l": "RHOQ GEFs activate RHOQ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10933", "l": "ATP + L-aspartate + L-citrulline => 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878117", "l": "RUNX3 binds ZFHX3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696267", "l": "RND3 binds GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.264511229695032", "identifiers": [{"i": "GO:0035250", "l": "UDP-galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40412", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46144", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73208", "l": "sulfate(out) + sulfite(in) => sulfate(in) + sulfite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35857", "l": "1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70409", "l": "(2E,6E,10E)-geranylgeranial + H2O2 + L-cysteine => [(2E,6E,10E)-geranylgeranyl]-L-cysteine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36331", "l": "ATP + dimethylallyl diphosphate = diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21985", "l": "3'-phosphoadenylyl sulfate + choline => adenosine 3',5'-bisphosphate + choline sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33159", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": []}, {"i": "EC:3.1.4.54", "l": "\"N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72691", "l": "Formation of the 43S pre-initiation complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001095", "l": "TFIIE-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase II transcription factor belonging to the TFIIE complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647660", "l": "GSDME (1-270) binds PIPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2990882", "l": "CDK1 phosphorylates NUP98 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1222376", "l": "NOX2 generates superoxide from oxygen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68411", "l": "(2R,3S)-iso(homo)3citrate + NAD(+) <=> 2-oxosuberate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13171", "l": "fumarate => maleate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9609921", "l": "SGTA binds Tail-anchored protein (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23018", "l": "(2R,3R)-dihydrokaempferol + H(+) + NADPH => (2R,3S,4S)-3,4-leucopelargonidin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20016", "l": "carbamoyl phosphate + L-aspartate <=> H(+) + N-carbamoyl-L-aspartate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047335", "l": "3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase activity", "d": ["Catalysis of the reaction: long-chain-polyphosphate + 3-phospho-D-glyceroyl-phosphate = long-chain-polyphosphate + 3-phosphoglycerate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34378", "l": "4-guanidinobutanamide + H2O <=> 4-guanidinobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865107", "l": "MICAL1 produces NADP+, H2O2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13126", "l": "CoA + glutathione disulfide => CoA-glutathione + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58328", "l": "(Z)-non-6-en-1-ol + NADP(+) = (Z)-non-6-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875523", "l": "MET binds TNS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61881", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047208", "l": "o-dihydroxycoumarin 7-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: 7,8-dihydroxycoumarin + UDP-D-glucose = daphnin + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694308", "l": "3a is externalized together with membrane structures (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10090", "l": "6(F)-alpha-D-galactosylsucrose + H(+) + UDP => sucrose + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032798", "l": "DOCK3 activates RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31318", "l": "(2R)-3-phosphoglycerate + GDP-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22758", "l": "a long-chain fatty aldehyde + H2O2 => a long-chain primary fatty alcohol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62067", "l": "2-deoxy-D-glucose 6-phosphate + NAD(+) <=> 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66162", "l": "CoA + H(+) + N-hexanoyltyramine => hexanoyl-CoA + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17564", "l": "acetylcholine + H2O <=> acetate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33766", "l": "a (2E)-enoyl-CoA + H(+) + NADPH <=> a 2,3-saturated acyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47989", "l": "2-dehydro-3-deoxy-L-galactonate + NAD(+) => 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814734", "l": "CDSN binds the cornified envelope (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13870", "l": "NAD(+) + prephenate => 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22166", "l": "globoside Forssman (d18:1(4E)) + H(+) + UDP => globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190520", "l": "Association of Golgi  transport vesicles with microtubules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29255", "l": "Ca(2+)(in) + Na(+)(out) = Ca(2+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45091", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41058", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62501", "l": "holo-[peptidyl-carrier protein] + L-arginyl-AMP => AMP + H(+) + L-arginyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909724", "l": "Recruitment of IFNAR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19649", "l": "ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)", "d": []}, {"i": "EC:6.1.1.12", "l": "\"aspartate--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70698", "l": "chloride(out) + glycine(out) + 3 Na(+)(out) <=> chloride(in) + glycine(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35196", "l": "L-quinate(in) => L-quinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49573", "l": "Fe-coproporphyrin III + 2 H(+) => coproporphyrin III + Fe(2+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678981", "l": "TLR9 processing at neutral pH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5606996", "l": "Soluble PROCR binds activated protein C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211224", "l": "Association of DFF40 with DFF45 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45028", "l": "(2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.12", "l": "\"(2S)-methylsuccinyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43472", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52711", "l": "GMP + H2O <=> D-ribose 5-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18344", "l": "D-xylono-1,4-lactone + H2O <=> D-xylonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45456", "l": "H2O + N-dodecanoylethanolamine = dodecanoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56698", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate => D-ribulose 5-phosphate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39645", "l": "(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+) => (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354087", "l": "Recruitment of GRB2 to p-PTK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22682", "l": "dUTP + NH4(+) => dCTP + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66232", "l": "IC-asc-C7-CoA + O2 = H2O2 + IC-asc-DeltaC7-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624800", "l": "CDK1 phosphorylates LBR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627775", "l": "Autophosphorylation of PAK1,2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16932", "l": "2 benzoyl-CoA + L-ornithine <=> 2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65474", "l": "CoA + ethyl 2-methylbutanoate => 2-methylbutanoyl-CoA + ethanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.69", "l": "\"biflaviolin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55031", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine <=> an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686338", "l": "SARS-CoV-1 3a binds the lysosomal membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047994", "l": "hydroxymethylglutaryl-CoA hydrolase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2059926", "l": "NPHP4 protein binds LATS proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55624", "l": "an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + H2O = 3-methylcytosine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14197", "l": "ATP + L-aspartate + NH4(+) = ADP + H(+) + L-asparagine + phosphate", "d": []}, {"i": "EC:6.3.1.4", "l": "\"aspartate--ammonia ligase (ADP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64756", "l": "H2O + S-benzyl-L-cysteine = benzylthiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23214", "l": "acetate + beta-alanine => H2O + N-acetyl-beta-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53615", "l": "CTP + D-ribulose 5-phosphate + H(+) <=> CDP-D-ribulose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12797", "l": "(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + scopolamine + succinate", "d": []}, {"i": "EC:1.14.20.13", "l": "\"6beta-hydroxyhyoscyamine epoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66927", "l": "[(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA <=> [(R)-3-hydroxyalkanoate](n+1) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23651", "l": "dTDP-6-deoxy-beta-L-talose + NADP(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0043867", "l": "7-cyano-7-deazaguanine tRNA-ribosyltransferase activity", "d": ["Catalysis of the reaction: tRNA guanine + 7-cyano-7-deazaguanine = tRNA 7-cyano-7-deazaguanine + guanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70532", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50235", "l": "8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51623", "l": "CTP + formate + H(+) <=> CO2 + dCTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64516", "l": "2-hydroxyethane-1-sulfonate + NAD(+) = H(+) + NADH + sulfoacetaldehyde", "d": []}, {"i": "EC:1.1.1.433", "l": "\"sulfoacetaldehyde reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.61", "l": "\"kexin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64713", "l": "1-propanol + NADP(+) => H(+) + NADPH + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.-.-.-", "l": "\"Oxidoreductases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140394", "l": "ABC-type azole transporter activity", "d": ["Enables the transfer of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other according to the reaction: ATP + H2O + azole(in) = ADP + phosphate + azole(out)."]}, {"i": "RHEA:33503", "l": "ATP + H2O + itraconazole(in) = ADP + H(+) + itraconazole(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74552", "l": "H2O + L-seryl-tRNA(Ser) => L-serine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534378", "l": "Hv1 Mediated H+ Permeability (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1011598", "l": "DOCKs bind to RhoGEFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19900", "l": "H(+) + 2 L-arginine + 3 NADPH + 4 O2 <=> 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24549", "l": "an N(6)-acyl-L-lysine + H2O => a carboxylate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64401", "l": "an L-amino acid tripeptide(out) + H(+)(out) => an L-amino acid tripeptide(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63630", "l": "AMP + diphosphate + hexadecanoyl-[ACP] => ATP + hexadecanoate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9696271", "l": "RND1 binds effectors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59859", "l": "Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium <=> methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55207", "l": "5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25426", "l": "5-phospho-alpha-D-ribose 1-diphosphate + guanine => diphosphate + GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36578", "l": "(9Z)-octadecenoyl-CoA + sphinganine <=> CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58217", "l": "A + dihydroserpentine => AH2 + serpentine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28612", "l": "diphosphate + H(+) + XMP => H2O + XTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444171", "l": "Receptor FFAR2 binds carboxylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448958", "l": "Nuclear translocation of p38 MAPK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645428", "l": "ALPK1 binds ADP-heptose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847968", "l": "PTEN binds FRK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74885", "l": "GUCYs converts GTP to cGMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198458", "l": "Efflux of Glc from the endoplasmic reticulum (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2328037", "l": "Fibrillin-1 binds integrins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74800", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39938", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34219", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.85", "l": "\"2-hydroxymuconate-6-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24181", "l": "2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61154", "l": "CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => (E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013158", "l": "CDC42 GDIs block activation of CDC42 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40561", "l": "dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+) => dTDP-beta-L-evernosamine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043799", "l": "glycine oxidase activity", "d": ["Catalysis of the reactions: (1) glycine + H2O + O2 = glyoxylate + NH3 + hydrogen peroxide; (2) D-alanine + H2O + O2 = pyruvate + NH3 + hydrogen peroxide; (3) sarcosine + H2O + O2 = glyoxylate + methylamine + hydrogen peroxide; (4) N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48724", "l": "aurachin B + H(+) + H2O = 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21984", "l": "3'-phosphoadenylyl sulfate + choline = adenosine 3',5'-bisphosphate + choline sulfate + H(+)", "d": []}, {"i": "EC:2.8.2.6", "l": "\"choline sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39105", "l": "ADP + H(+) + phosphate + sitosterol(out) => ATP + H2O + sitosterol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691154", "l": "HFE binds TFRC dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66557", "l": "dopamine + L-glutaminyl-[protein] => 5-dopaminyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12070", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[ACP] => apo-[ACP] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692437", "l": "ANG binds F-actin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10557", "l": "D-glyceraldehyde 3-phosphate + L-arginine => H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1264832", "l": "JAK1 binds IL7R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018613", "l": "9-fluorenone dioxygenase activity", "d": ["Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66318", "l": "alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+) => an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019871", "l": "sodium channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a sodium channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67408", "l": "gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + thymol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51025", "l": "H(+) + NADH + O2 + toluene-4-sulfonate => 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362427", "l": "Hh-Np binds GPC5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168445", "l": "PTP1B binds the GH receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877620", "l": "ECE2 cleaves EDN1(53-90) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634861", "l": "NPAS4 binds ARNT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944250", "l": "Association of procollagen type XXV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173705", "l": "C5b binds C6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75802", "l": "Na(+)(out) + pyruvate(out) <=> Na(+)(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25169", "l": "6-hydroxyhexan-6-olide => 6-oxohexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.52", "l": "\"preflagellin peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19223", "l": "formate + H(+) + methanol => 2 formaldehyde + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63645", "l": "GDP-beta-L-fucose + L-seryl-[protein] => 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102577", "l": "3-oxo-palmitate decarboxylase activity", "d": ["Catalysis of the reaction: 3-oxopalmitic acid + H+ = 2-pentadecanone + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592240", "l": "Formation of NRF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59049", "l": "D-ornithine + H(+) => CO2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45304", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75081", "l": "Formation of AT-AC B Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37806", "l": "a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654167", "l": "Activated FGFR1 binds PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2509827", "l": "ITPA hydrolyses ITP to IMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102656", "l": "1-18:2-2-trans-16:1-phosphatidylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69228", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate = an epithionitrile + sulfate", "d": []}, {"i": "EC:4.8.1.6", "l": "\"N-(sulfonatooxy)alkenimidothioic acid sulfate-lyase (epithionitrile-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786421", "l": "CHIA hydrolyses chitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13678", "l": "D-ribulose 5-phosphate => D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051982", "l": "copper-nicotianamine transmembrane transporter activity", "d": ["Enables the transfer of the copper chelate copper-nicotianamine (Cu-NA) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874849", "l": "CREBRF binds CREB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871265", "l": "YAP1 binds TEAD4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381446", "l": "Thrombin proteolyzes IGF:IGFBP3:ALS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70422", "l": "3,4-dihydroxyphenylacetyl-CoA + H2O <=> 3,4-dihydroxyphenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39443", "l": "(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878056", "l": "RUNX1:CBFB binds EP300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44964", "l": "(2E)-dodecenoyl-CoA + H(+) + NADPH = dodecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70769", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70414", "l": "4-hydroxyphenylacetyl-CoA + H2O <=> 4-hydroxyphenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21980", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}, {"i": "EC:2.8.2.8", "l": "\"[heparan sulfate]-glucosamine N-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694409", "l": "Nucleotide exchange on RAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692408", "l": "NPR2 binds NPPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015039", "l": "NADPH-adrenodoxin reductase activity", "d": ["Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15030", "l": "D-mannitol + NAD(+) => D-mannose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103063", "l": "trans-keto-C61-meroacyl-AMP ligase activity", "d": ["Catalysis of the reaction: ATP(4-) + H2O + a trans-keto-C61-meroacyl-[acp] <=> diphosphoric acid + a trans-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48460", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = 2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56681", "l": "beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177937", "l": "Phosphorylation of EGFR by SRC kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40913", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706298", "l": "Active FLT3 binds to CSK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38573", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) => a 1,2-diacyl-sn-glycero-3-phosphocholine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004780", "l": "sulfate adenylyltransferase (ADP) activity", "d": ["Catalysis of the reaction: ADP + H+ + sulfate = 5'-adenylyl sulfate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050303", "l": "lysine 6-dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67204", "l": "H2O + N-acetyltryptamine = acetate + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53484", "l": "androst-4-ene-3,11,17-trione + H(+) + NADPH = 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875443", "l": "USP8 deubiquitinates LRIG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0052820", "l": "DNA-1,N6-ethenoadenine N-glycosylase activity", "d": ["Catalysis of the reaction: DNA with 1-N6-ethenoadenine + H2O = DNA with abasic site + 1-N6-ethenoadenine. This reaction is the removal of 1,N6-ethenoadenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592371", "l": "Initial activation of proMMP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-167415", "l": "G-protein alpha subunit is inactivated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29817", "l": "ADP + H(+) + L-proline(in) + phosphate => ATP + H2O + L-proline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58854", "l": "(6E)-8-oxogeranial + H(+) + NADH => (6E)-8-oxogeraniol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33394", "l": "C20 sphinganine 1-phosphate + H2O <=> C20 sphinganine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225947", "l": "Binding of SHC1 to p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51058", "l": "AH2 + androsta-1,4-diene-3,17-dione => A + androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622367", "l": "CEBPA mRNA is translated to yield CEBPA protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23648", "l": "dTDP-6-deoxy-beta-L-talose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657641", "l": "ALKBH2 binds alkylated DNA containing 1-meA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218836", "l": "PTK2beta binds alphaVbeta3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29833", "l": "Ni(2+)(out) => Ni(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77589", "l": "Recognition of AAUAAA sequence by CPSF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21018", "l": "L-aspartate + NH4(+) => H2O + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38276", "l": "(3R)-citramalyl-CoA => acetyl-CoA + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0047865", "l": "dimethylglycine dehydrogenase activity", "d": ["Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018762", "l": "aliphatic nitrilase activity", "d": ["Catalysis of the reaction: R-CN + H2O = R-COOH + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43229", "l": "L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050385", "l": "ureidoglycolate lyase activity", "d": ["Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47335", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173709", "l": "C7 binds C5b:C6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45011", "l": "H2O + N-(octadecanoyl)-sphinganine <=> octadecanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69068", "l": "RFC dissociates after sliding clamp formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49615", "l": "(R)-2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.47", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.427", "l": "\"D-arabinose 1-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071160", "l": "cyanophycin synthetase activity (L-aspartate-adding)", "d": ["Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62329", "l": "(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) => (+)-malbrancheamide + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37854", "l": "13-deoxydaunorubicin + H(+) + NADPH + O2 <=> 13-dihydrodaunorubicin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432527", "l": "Nuclear PP2A dephosphorylates phosphorylated PER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114553", "l": "Activation of conventional Protein Kinase C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102781", "l": "isofucosterol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + isofucosterol + O2 + NADPH <=> (22alpha)-hydroxy-isofucosterol + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875558", "l": "RAPGEF1 binds CRK,CRKL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0050750", "l": "low-density lipoprotein particle receptor binding", "d": ["Binding to a low-density lipoprotein receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668545", "l": "NIK autophosphorylates on T559 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44433", "l": "2 a 1-acylglycerol => a 1,2-diacylglycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350901", "l": "Iodide is organified (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333671", "l": "CLCAs self cleave (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73938", "l": "griseophenone B + H(+) + O2 + reduced [NADPH--hemoprotein reductase] <=> desmethyl-dehydrogriseofulvin + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940309", "l": "Expression of PERM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706354", "l": "Ubiquitination of FLT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26094", "l": "(4R)-limonene + H(+) + NADH + O2 => H2O + limonene 1,2-epoxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43320", "l": "1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38937", "l": "cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein] => cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200646", "l": "Cytosolic folate export across the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39213", "l": "(2E)-hexacosenoyl-CoA + H2O => (3R)-hydroxyhexacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190141", "l": "ALAD binds to Pb2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429036", "l": "SLC2A9 transports Fru, Glc, urate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32818", "l": "Hg(2+)(in) <=> Hg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707586", "l": "FeHM oxidises LDL,HDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392749", "l": "Transport of L1 into endosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53196", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19705", "l": "CoA + hexadecanal + NAD(+) = H(+) + hexadecanoyl-CoA + NADH", "d": []}, {"i": "EC:1.2.1.42", "l": "\"hexadecanal dehydrogenase (acylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73217", "l": "sulfate(in) + thiosulfate(out) => sulfate(out) + thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033927", "l": "glucan 1,4-alpha-maltohexaosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltohexaose residues from the non-reducing chain ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1470010", "l": "Dimerization of STATs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-517705", "l": "p-S318,221-HuR binds mRNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47303", "l": "(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21880", "l": "2 H(+) + O2 + oxalate = 2 CO2 + H2O2", "d": []}, {"i": "EC:1.2.3.4", "l": "\"oxalate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034841", "l": "mentha-1,3-dione-CoA ligase activity", "d": ["Catalysis of the reaction: mentha-1,3-dione + CoASH = 3,7-dimethyl-5-oxo-octyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.69", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1253343", "l": "WWOX binds ERBB4s80 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050461", "l": "L-mimosine synthase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridinium-1-yl)-L-alanine + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32648", "l": "erythromycin C + S-adenosyl-L-methionine => erythromycin A + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50493", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611851", "l": "ADRB2 bind ADR,NAd (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378975", "l": "Follitropin is a heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37620", "l": "(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641231", "l": "TLE recruits HDAC1 to WNT promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16409", "l": "1,2-dihydrovomilenine + NADP(+) = H(+) + NADPH + vomilenine", "d": []}, {"i": "EC:1.5.1.32", "l": "\"vomilenine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009030", "l": "thiamine-phosphate kinase activity", "d": ["Catalysis of the reaction: ATP + thiamine phosphate = ADP + H+ + thiamine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43305", "l": "3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer => 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13284", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) <=> 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52082", "l": "12-hydroxyoctadecanoate + H(+) + octadecanoate => 12-octadecanoyloxy-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56165", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine => (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66211", "l": "(8R)-8-hydroxynonanoyl-CoA + O2 <=> (2E,8R)-8-hydroxynonenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21610", "l": "2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine => isoliquiritigenin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29668", "l": "H2O(in) => H2O(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098626", "l": "methylseleninic acid reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + CH3SeO2H => NADP+ + CH3SeOH + H2O."]}, {"i": "REACT:R-HSA-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250607", "l": "botD HC:LC binds SV2A or B or C and GD2 on the target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61459", "l": "7-chlorotetracycline + H(+) + NADPH + O2 <=> (1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54055", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + tau-cadinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40033", "l": "diphosphate + ent-manool => ent-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010491", "l": "UTP:arabinose-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: alpha-L-arabinose 1-phosphate + UTP = UDP-L-arabinose + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051879", "l": "Hsp90 protein binding", "d": ["Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33105", "l": "alpha-muurolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49747", "l": "deoxyviolaceinate + H(+) + O2 <=> CO2 + deoxyviolacein + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866269", "l": "ARRB bind GPCRs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14559", "l": "D-glucose + vomilenine => H2O + raucaffricine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15275", "l": "3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39948", "l": "1,3-diacyl-sn-glycerol + H2O => a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49297", "l": "keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + L-sorbose 1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0034431", "l": "bis(5'-adenosyl)-hexaphosphatase activity", "d": ["Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate."]}, {"i": "RHEA:32047", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = adenosine 5'-pentaphosphate + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49116", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate = deoxyviolaceinate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26498", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose = delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785181", "l": "LMF1,2 bind LIPC dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67966", "l": "4-dimethylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine => 4-methylamino-L-phenylalanine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56010", "l": "4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => 4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26054", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798373", "l": "MDM2 ubiquitinates DYRK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.161", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47602", "l": "CMP + ganglioside GM4 (d18:1(4E)) + H(+) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419003", "l": "Interaction of Nectins with Afadin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56486", "l": "gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69025", "l": "H(+) + N-hydroxy-L-aspartate + NADPH + O2 => H2O + N,N-dihydroxy-L-aspartate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68322", "l": "1D-myo-inositol 2,5-bisphosphate + phosphate => 1D-myo-inositol 2,4,5-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41138", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11704", "l": "2 H(+) + N-(carboxyaminomethyl)urea = CO2 + N-(aminomethyl)urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12164", "l": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+)", "d": []}, {"i": "EC:2.8.2.1", "l": "\"aryl sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953339", "l": "DNPH1 hydrolyses dGMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19307", "l": "2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA => 3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854209", "l": "TBC1D10A binds JFC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0001864", "l": "pentraxin binding", "d": ["Binding to a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50816", "l": "androst-4-ene-3,17-dione + H(+) + NADPH = 5alpha-androstan-3,17-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12799", "l": "CO2 + H(+) + H2O + scopolamine + succinate => (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24896", "l": "isopimpinellin + S-adenosyl-L-homocysteine => 5-hydroxyxanthotoxin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29174", "l": "a ubiquinol + 2 O2 <=> a ubiquinone + 2 H(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983152", "l": "Transfer of ubiquitin from E1 to E2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68227", "l": "2-oxoglutarate + H(+) + O2 + prekainate <=> CO2 + H2O + kainate lactone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20545", "l": "H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.9", "l": "\"kynurenine 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57175", "l": "(S)-2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69140", "l": "RPA binds to the Flap (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9718379", "l": "GNRHR binds chemical antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24214", "l": "4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+) => 5-(2-hydroxyethyl)-4-methylthiazole + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32250", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) <=> (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62669", "l": "deoxyherqueinone + H(+) + NADPH + O2 => H2O + herqueinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40353", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013069", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938121", "l": "SERPINB13 binds CTSK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265823", "l": "Association between RAD9 and TopBP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19201", "l": "2'-deoxyguanosine + ATP = ADP + dGMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617641", "l": "MAFB (KREISLER) and HOXB1:PBX1:PKNOX1 (HOXB1:PBX1:PREP1) activate HOXA3 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982617", "l": "CYGB:O2 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16702", "l": "17alpha-estradiol + NAD(+) => estrone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61445", "l": "a tetracycline + H(+) + NADPH + O2 => an 11a-hydroxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29814", "l": "ATP + H2O + thiamine(out) <=> ADP + H(+) + phosphate + thiamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140314", "l": "calcium ion sequestering activity", "d": ["Binding to a calcium ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42847", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH <=> 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445714", "l": "Aquaporin-3 passively transports water out of cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77608", "l": "Binding of A1CF to stem-looped RNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043885", "l": "carbon-monoxide dehydrogenase (ferredoxin) activity", "d": ["Catalysis of the reaction: CO + H2O + oxidized ferredoxin = CO2 + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052723", "l": "inositol hexakisphosphate 1-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875591", "l": "DOCK7 activates RAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.535054500181104", "identifiers": [{"i": "GO:0016679", "l": "oxidoreductase activity, acting on diphenols and related substances as donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}, {"i": "EC:1.10.-.-", "l": "\"Acting on diphenols and related substances as donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183126", "l": "Factor B binds to surface-associated C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68589", "l": "(6S)-10-formyltetrahydrofolate + GDP-alpha-D-perosamine => (6S)-5,6,7,8-tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11930", "l": "H(+) + H2O + hydrazine => hydroxylamine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050009", "l": "isopropanol dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + propan-2-ol = acetone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69837", "l": "(22S)-22-hydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => campesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70979", "l": "4-aminobutanoate(out) + n H(+)(in) = 4-aminobutanoate(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75748", "l": "10-oxooctadecanoate + H(+) + NADH => 10-hydroxyoctadecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683879", "l": "SFTPA genes produce SFTPA proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36968", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17498", "l": "formononetin + UDP-alpha-D-glucose => ononin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828175", "l": "Formation of the NSL complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685604", "l": "SLAMF6 binds SLAMF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2247511", "l": "STAB2:ligand is endocytosed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684006", "l": "KPNA2 translocates NBN to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694454", "l": "Replication transcription complex binds SARS-CoV-2 genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665686", "l": "FMNL1 binds CDC42:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005143", "l": "interleukin-12 receptor binding", "d": ["Binding to an interleukin-12 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51834", "l": "AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48343", "l": "a medium chain fatty acid + ATP + CoA <=> a medium-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9728150", "l": "SLC5A2 binds gliflozins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14818", "l": "4-maleylacetoacetate => 4-fumarylacetoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42987", "l": "(+)-copalyl diphosphate <=> diphosphate + pimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60981", "l": "12-hydroxydodecanoate + NAD(+) => 12-oxododecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389156", "l": "CSF1 dimer binds CSF1R or IL34 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68878", "l": "AMP + diphosphate + NADP(+) + piperonal => ATP + H(+) + NADPH + piperonylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296301", "l": "CCRL2 binds CCL19 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35611", "l": "menadiol + 2 O2 = 2 H(+) + menadione + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72614", "l": "H(+)(out) + L-alanyl-L-lysine(out) <=> H(+)(in) + L-alanyl-L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49765", "l": "ethylenediaminetriacetate + FMNH2 + O2 => ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35620", "l": "L-idarate => D-glucarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.203", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015129", "l": "lactate transmembrane transporter activity", "d": ["Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018754", "l": "GDIs bind RHOH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42543", "l": "uridine(13) in tRNA <=> pseudouridine(13) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72159", "l": "glutarate(in) + taurocholate(out) = glutarate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850797", "l": "SPINK6 binds KLK13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174070", "l": "Association of Cdh1 with the APC/C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59312", "l": "D-galactose + O2 = D-galactono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64274", "l": "benzaldehyde + L-alanine => benzylamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22575", "l": "A + H2O + N-methyl-L-glutamate <=> AH2 + formaldehyde + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0004558", "l": "alpha-1,4-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165162", "l": "Phosphorylation of TSC2 by PKB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65934", "l": "3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine => 3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61298", "l": "5-deoxy-D-ribulose 1-phosphate => 5-deoxy-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23656", "l": "2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H(+)", "d": []}, {"i": "EC:5.5.1.2", "l": "\"3-carboxy-cis,cis-muconate cycloisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69861", "l": "a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in 12S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009451", "l": "RUNX2 binds SMURF1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57709", "l": "(E)-coniferaldehyde + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-4-trans-coniferyl aldehyde + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33070", "l": "(4R)-hydroxysphinganine 1-phosphate + H2O <=> (4R)-hydroxysphinganine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617829", "l": "Assembly of IFT A complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198714", "l": "ERK5 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635102", "l": "GPR161 is internalized (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694521", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49057", "l": "asperlicin C + H(+) + NADPH + O2 => asperlicin E + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25443", "l": "(2E,6E)-farnesyl diphosphate <=> delta-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28007", "l": "H2O + N(alpha)-methyl-L-tryptophan + O2 => formaldehyde + H2O2 + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35500", "l": "11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51206", "l": "12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH => 6-trans-leukotriene B4 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592371", "l": "Initial activation of proMMP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15155", "l": "4-(beta-D-glucosyloxy)benzoate + H(+) + UDP => 4-hydroxybenzoate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373075", "l": "Metabotropic glutamate receptors bind glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31586", "l": "2-oxo-dATP + H2O <=> 2-oxo-dAMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015092", "l": "high-affinity ferric iron transmembrane transporter activity", "d": ["Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63905", "l": "2 3-phenylpyruvate + H(+) => H2O + phenguignardate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.42903515889401", "identifiers": [{"i": "GO:0038024", "l": "cargo receptor activity", "d": ["Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65619", "l": "A + cholest-4-en-3-one + H2O <=> 25-hydroxycholest-4-en-3-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33901", "l": "FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose => FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373734", "l": "Nephrin interacts with Podocin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429815", "l": "Formation Of Bloc-1 Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74707", "l": "Binding of IRS to insulin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849900", "l": "SALMs1-3 bind each other in cis interactions (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67825", "l": "a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O => a lipid X + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047393", "l": "glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity", "d": ["Catalysis of the reaction: glycerol 1,2-cyclic phosphate + H2O = glycerol 1-phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20727", "l": "a 4-saturated-(3S)-3-hydroxyacyl-CoA <=> a (3E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39057", "l": "22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34616", "l": "2-hydroxyethylphosphonate + O2 => H(+) + hydrogencarbonate + methylphosphonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56365", "l": "13-dihydrocarminomycin + H(+) + NADPH + O2 => carminomycin + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62744", "l": "H2O + mevastatin = (S)-2-methylbutanoate + compactin diol lactone + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098641", "l": "cadherin binding involved in cell-cell adhesion", "d": ["Any cadherin binding that occurs as part of the process of cell-cell adhesion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30802", "l": "(3S)-3-hydroxybutanoyl-CoA + NAD(+) <=> acetoacetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451310", "l": "Activation of Edited Kainate receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68195", "l": "decanoyl-CoA + phytol <=> CoA + decanoate phytyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76075", "l": "a dicarboxylate(in) + L-erythro-7,8-dihydrobiopterin(out) = a dicarboxylate(out) + L-erythro-7,8-dihydrobiopterin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021406", "l": "NOTCH3 coactivator complex binds PBX1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66530", "l": "diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] => ATP + O-(5'-adenylyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41314", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036426", "l": "ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity", "d": ["Catalysis of the reaction: ditrans,octacis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate+ GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70258", "l": "1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25971", "l": "(S)-benzoin + NADP(+) <=> benzil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936475", "l": "Negative regulation of DDX58/IFIH1 signaling by RNF216 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009485", "l": "IL34:CSF1 binds CSF1R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39502", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA <=> (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9677050", "l": "Formation of the GCN5-ATAC complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38445", "l": "a wax ester + CoA => a fatty acyl-CoA + a long chain fatty alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53556", "l": "(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667037", "l": "RHPN2 binds RHOB:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670417", "l": "Dimerization of STATs downstream of KIT mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917700", "l": "MVB Vesicle Formation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047933", "l": "glucose-1,6-bisphosphate synthase activity", "d": ["Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37885", "l": "acetate + oxalyl-CoA => acetyl-CoA + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9007901", "l": "IL1F10 binds IL1RL2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29277", "l": "L-isoleucine(out) + Na(+)(out) => L-isoleucine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981657", "l": "IL34 dimer binds PTPRZ1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371435", "l": "Constitutive phosphorylation by GSK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57533", "l": "a 5'-end ribonucleotide-RNA + ATP + H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0043860", "l": "cyanophycin synthetase activity", "d": ["Catalysis of the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176517", "l": "SULTs transfer (SO4)2- group to PREG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653957", "l": "Rag dimer formation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67447", "l": "an (R)-2-hydroxy-long-chain-fatty acyl-CoA <=> a long-chain fatty aldehyde + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75108", "l": "32-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 32-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632039", "l": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73932", "l": "Resynthesis of excised residue by POLB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51922", "l": "A + a quinol => a quinone + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62572", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine = glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25685", "l": "L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29219", "l": "a menaquinone + sn-glycerol 3-phosphate = a menaquinol + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61671", "l": "ATP + CoA + salicylate <=> 2-hydroxybenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10389", "l": "GTP + oxaloacetate => CO2 + GDP + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814831", "l": "TBC1D20 binds RAB1:GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53490", "l": "11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+) => 11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102450", "l": "kaempferide 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: kaempferide + S-adenosyl-L-methionine <=> 7,4'-dimethylkaempferol + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56767", "l": "12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 <=> 12-epi-fischerindole G + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29354", "l": "Zn(2+)(in) <=> Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18684", "l": "phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine <=> phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74264", "l": "n H(+)(out) + spermine(in) => n H(+)(in) + spermine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43909", "l": "beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O => D-galactose + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46355", "l": "(2E)-decenoyl-CoA + H2O <=> 3-hydroxydecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707659", "l": "Hemes:LY96 activates TLR4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56756", "l": "5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211983", "l": "CYP2J2 oxidises ARA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41976", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) = CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18008", "l": "D-threitol + NADP(+) <=> D-erythrulose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9676255", "l": "Formation of the MLL2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20642", "l": "H2O + L-histidinol + 2 NAD(+) => 3 H(+) + L-histidine + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654163", "l": "Activated FGFR4 binds PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983150", "l": "Proteasomal cleavage of substrate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23223", "l": "4-chlorobenzoate + ATP + CoA <=> 4-chlorobenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68174", "l": "CO2 + H2O + isodomoate A + succinate => 2-oxoglutarate + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29991", "l": "H(+)(in) + L-lyxopyranose(in) = H(+)(out) + L-lyxopyranose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54361", "l": "4-methyl-2-oxopentanoate + H(+) => 3-methylbutanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47254", "l": "6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56621", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O => 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430311", "l": "Rsu-1 interacts with Pinch1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202500", "l": "Activation of IKK complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31332", "l": "ATP + H(+) + molybdopterin => adenylyl-molybdopterin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.3.7", "l": "\"guanidinobutyrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034710", "l": "inhibin complex binding", "d": ["Binding to an inhibin complex, a dimer of one inhibin-alpha subunit and one inhibin-beta subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56783", "l": "(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001851", "l": "complement component C3b binding", "d": ["Binding to a C3b product of the complement cascade."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034905", "l": "5-chloro-4-hydroxy-2-oxopentanate aldolase activity", "d": ["Catalysis of the reaction: 5-chloro-4-hydroxy-2-oxopentanate = pyruvate + chloroacetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10189", "l": "acetoacetyl-CoA + acetyl-CoA + H2O => (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60894", "l": "a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+) => a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33481", "l": "CoA + lanosteryl ester => an acyl-CoA + lanosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679205", "l": "ULK1 phosphorylates Beclin-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640195", "l": "RRAGA,B hydrolyzes GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004163", "l": "diphosphomevalonate decarboxylase activity", "d": ["Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO2 + H+ + isopentenyl diphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39477", "l": "(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O => (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26497", "l": "chloride + FADH2 + L-tryptophan + O2 <=> 7-chloro-L-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57947", "l": "H(+) + H2O2 + harderoheme III <=> CO2 + 2 H2O + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38604", "l": "NADP(+) => 2'-phospho-cyclic ADP-ribose + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60099", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) <=> 3-dehydro-4alpha-methylzymosterol + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22467", "l": "L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.253913141376358", "identifiers": [{"i": "GO:0003924", "l": "GTPase activity", "d": ["Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64409", "l": "2 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) => 2 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54352", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65424", "l": "AMP(in) + NAD(+)(out) = AMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45908", "l": "chloroorienticin B + dTDP-beta-L-vancosamine = chloroeremomycin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25500", "l": "(2E)-geranyl diphosphate = diphosphate + terpinolene", "d": []}, {"i": "EC:4.2.3.113", "l": "\"terpinolene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018678", "l": "4-hydroxybenzoate 1-hydroxylase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = hydroquinone + NADP+ + H2O + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33947", "l": "2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine = 2'-N-acetylparomamine + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.283", "l": "\"2-deoxystreptamine N-acetyl-D-glucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202328", "l": "Translocation of PKC theta to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34431", "l": "(+)-secoisolariciresinol + NADP(+) = (-)-lariciresinol + H(+) + NADPH", "d": []}, {"i": "EC:1.23.1.4", "l": "\"(-)-lariciresinol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40039", "l": "2 ATP + 2 L-glutamate + N-acetyl-L-aspartate = 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate", "d": []}, {"i": "EC:6.3.2.42", "l": "\"N-acetylaspartylglutamylglutamate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45257", "l": "hexadecanoate(out) => hexadecanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937807", "l": "SRC phosphorylates RUNX3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51523", "l": "(S)-reticuline + S-adenosyl-L-methionine <=> (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.15", "l": "\"DNA-deoxyinosine glycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41727", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47653", "l": "D-ribitol 1-phosphate + H2O => phosphate + ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004789", "l": "thiamine-phosphate diphosphorylase activity", "d": ["Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H+ = diphosphate + thiamine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350598", "l": "Arginine<=>Agmatine+CO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381668", "l": "cAMP activates EPAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73883", "l": "guanidine(out) = guanidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37961", "l": "(13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23093", "l": "H(+) + H2O + hydroxyatrazine => ethylamine + N-isopropylammelide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16359", "l": "AH2 + fumarate => A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444171", "l": "Receptor FFAR2 binds carboxylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977605", "l": "Factor H displaces Bb (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35978", "l": "2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 <=> A + CO2 + H2O + succinate + verruculogen", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67461", "l": "(R)-malate + A => AH2 + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051698", "l": "saccharopine oxidase activity", "d": ["Catalysis of the reaction: L-saccharopine + O2 = L-2-aminoadipic 6-semialdehyde + L-glutamate + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54135", "l": "a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate <=> a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.42903515889401", "identifiers": [{"i": "GO:0016803", "l": "ether hydrolase activity", "d": ["Catalysis of the hydrolysis of an ether bond, -O-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9017491", "l": "RHOJ GEFs activate RHOJ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050116", "l": "N,N-dimethylformamidase activity", "d": ["Catalysis of the reaction: N,N-dimethylformamide + H2O = dimethylamine + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11714", "l": "2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48486", "l": "an aliphatic alcohol + H(+) + propanoate => a propanoate ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985943", "l": "p-Y701-STAT1 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19618", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75414", "l": "demethyllactenocin + S-adenosyl-L-methionine <=> H(+) + lactenocin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322422", "l": "Beta-catenin recruits SMARCA4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67716", "l": "NADPH + 2 oxidized [2Fe-2S]-[protein] = H(+) + NADP(+) + 2 reduced [2Fe-2S]-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26521", "l": "3-hydroxypropanoyl-CoA <=> acryloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37841", "l": "1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5618331", "l": "HDAC6 deacetylates microtubules (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373746", "l": "SEMA4D interacts with CD45 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9687625", "l": "ATP binds MLKL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46275", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49221", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP => CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60111", "l": "(R)-3-(4-hydroxyphenyl)lactoyl-CoA <=> (E)-4-coumaroyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68610", "l": "Formation of ORC(2-5) complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46093", "l": "(25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030550", "l": "acetylcholine receptor inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of an acetylcholine receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018593", "l": "4-chlorophenoxyacetate monooxygenase activity", "d": ["Catalysis of the reaction: 4-chlorophenoxyacetate + 1/2 O2 = glyoxylate + 4-chlorophenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64009", "l": "(4R)-hydroxysphinganine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964619", "l": "PAK1 binds ARHGEF6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61050", "l": "H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase] => lochnericine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197690", "l": "Detachment of WASP/WAVE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015143", "l": "urate transmembrane transporter activity", "d": ["Enables the transfer of urate from one side of a membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43992", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 = 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0099122", "l": "RNA polymerase II C-terminal domain binding", "d": ["Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56876", "l": "(R)-N-acetyl-1-phenylethylamine + H2O = (R)-1-phenylethylamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862733", "l": "CCR2, CCR3 bind CCL13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865276", "l": "PDGF-AB clevage by Furin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1008200", "l": "NFE2 binds the beta globin locus control region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737035", "l": "L-Glutamate binds GRM1 (mGluR1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9005980", "l": "IL21 binds IL21R:JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389381", "l": "Gads binds CD28 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696813", "l": "TSEN complex cleaves the intron from pre-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.3", "l": "\"mannuronate-specific alginate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204779", "l": "Interaction of Tie2 with Ang1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.1.2", "l": "\"NAD(P)(+) transhydrogenase (Re/Si-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810076", "l": "DDO oxidizes D-Asp to OA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.78", "l": "\"GDP-D-glucose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9678925", "l": "NR3C1 binds NR3C1 agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26164", "l": "AH2 + echinenone + O2 = 4'-hydroxyechinenone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58914", "l": "ADP + H(+) + iron(III) dicitrate(in) + phosphate => ATP + H2O + iron(III) dicitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102546", "l": "mannosylglycerate hydrolase activity", "d": ["Catalysis of the reaction: H2O + 2-(alpha-D-mannosyl)-D-glycerate <=> alpha-D-mannose + D-glycerate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57833", "l": "5-oxopentanoate + H2O + NADP(+) => glutarate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875374", "l": "MET binds LRIG1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5635854", "l": "GLI2,3 are degraded by the proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45119", "l": "(4R)-ipsdienol + NADP(+) <=> H(+) + ipsdienone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008587", "l": "IL37, IL37(?-218) binds IL18BP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693347", "l": "HTR1A binds 5HT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1461993", "l": "pro-HD5 is cleaved by trypsin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102121", "l": "ceramidase activity", "d": ["Catalysis of the reaction: H2O + a ceramide = a sphingoid base + a fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196773", "l": "COASY phosphorylates DP-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050625", "l": "2-hydroxy-1,4-benzoquinone reductase activity", "d": ["Catalysis of the reaction: 2-hydroxy-1,4-benzoquinone + 2 H+ + NADH = benzene-1,2,4-triol + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46375", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49925", "l": "(R)-carnitine(out) + O-acyl-(R)-carnitine(in) => (R)-carnitine(in) + O-acyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692437", "l": "ANG binds F-actin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944232", "l": "Association of procollagen type XII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58444", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871226", "l": "RET binds GFRA1,GFRA2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429730", "l": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60266", "l": "H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68822", "l": "(6E)-nerolidol + diphosphate => (2Z,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57896", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74331", "l": "O-butanoyl-(R)-carnitine(in) = O-butanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9718360", "l": "GNRHR binds GNRHR peptide agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15659", "l": "3-methylcatechol + CO2 + NADH => 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9692880", "l": "HRH3 binds Hist (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021609", "l": "ESR-associated SRC autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67609", "l": "H2O + N(6)-methyl-ATP => diphosphate + H(+) + N(6)-methyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606288", "l": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74647", "l": "GTP + N-acetyl-D-glucosamine = GDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848124", "l": "PTK6 phosphorylates STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73037", "l": "Co(2+)(in) + H(+)(in) => Co(2+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31081", "l": "3-methyl-(2E)-butenoyl-CoA + H2O => 3-hydroxyisovaleryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382057", "l": "Release of novel PDGFs as latent factors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9615348", "l": "AGT(34-41) binds to AGTR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58708", "l": "rifampicin ortho-naphthoquinone carboxamide = rifampicin para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66083", "l": "2-oxopentanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676599", "l": "sBAFF trimer binds BAFFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60216", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19416", "l": "ATP + L-phenylalanine + tRNA(Phe) <=> AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24243", "l": "A + AMP + 2 H(+) + sulfite <=> adenosine 5'-phosphosulfate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20894", "l": "butanoyl phosphate + CoA => butanoyl-CoA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54660", "l": "an aromatic (S)-hydroxynitrile = an aromatic aldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052874", "l": "FMN reductase (NADH) activity", "d": ["Catalysis of the reaction: FMNH2 + NAD+ = FMN + NADH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33192", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65807", "l": "a 5'-end L-tyrosylphosphate-2'-deoxynucleoside-DNA + H2O <=> a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+) + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18379", "l": "ADP + H(+) + streptomycin 3''-phosphate => ATP + streptomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994148", "l": "LRRC16A binds F-actin capping protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21071", "l": "A + H2O + nitrite <=> AH2 + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225957", "l": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61509", "l": "peonidin + UDP-alpha-D-glucose => peonidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50213", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42972", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a cardiolipin + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708457", "l": "HM13 cleaves HMOX1 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018774", "l": "RHOBTB1 binds GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873917", "l": "Translocation of STAT1 dimer to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66368", "l": "6-methyl-3,7-dioxodecanedioyl-CoA + CoA = 4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159771", "l": "Furin cleaves pro-protein C to protein C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-517674", "l": "p-S158,221-HuR binds mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706293", "l": "Active FLT3 binds to CBL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54210", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O => 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800798", "l": "The PIDDosome binds CASP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24701", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) <=> 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39474", "l": "(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65482", "l": "CoA + hexyl 2-methylbutanoate => 2-methylbutanoyl-CoA + hexan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36424", "l": "2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43206", "l": "2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.240", "l": "\"2-polyprenylphenol 6-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44730", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68320", "l": "1D-myo-inositol 2,4,5-triphosphate + H2O = 1D-myo-inositol 2,5-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21656", "l": "CDP-alpha-D-paratose = CDP-3,6-dideoxy-alpha-D-mannose", "d": []}, {"i": "EC:5.1.3.10", "l": "\"CDP-paratose 2-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64483", "l": "4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate <=> (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75850", "l": "Addition of the third nucleotide on the nascent transcript (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390459", "l": "Exchange of ADP for ATP in CCT/TriC:actin complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203070", "l": "Association of profilin with monomeric actin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44860", "l": "(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8-dimethylnonanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70403", "l": "(9Z)-hexadecenoyl-CoA + 3-oxosphinganine = CoA + H(+) + N-(9Z-hexadecenoyl)-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59321", "l": "D-cellobiono-1,5-lactone + H2O => 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73456", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + salvigenin => 8-hydroxysalvigenin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112514", "l": "JAK activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29156", "l": "2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) => 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57102", "l": "S-methyl-1-thio-D-xylulose 5-phosphate => S-methyl-5-thio-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382056", "l": "Crk binds to the active PDGF receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395517", "l": "NADPH transfers electrons to FDXR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035639", "l": "purine ribonucleoside triphosphate binding", "d": ["Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46395", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102001", "l": "isoleucine N-monooxygenase (oxime forming) activity", "d": ["Catalysis of the reaction: L-isoleucine + 2 O2 + 2 NADPH(4-) + 2 H+ <=> (E)-2-methylbutanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58019", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57819", "l": "dGMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690701", "l": "SHP1 binds p-CD22 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38355", "l": "(R)-3-phenyllactoyl-CoA = (E)-cinnamoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630055", "l": "NTHL1 D239Y does not cleave dihydrouracil (DHU) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451310", "l": "Activation of Edited Kainate receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46887", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140795", "l": "histone H3R2 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H3 L-arginyl (position 2)= histone H3 L-citrullyl (position 2) + NH4+, resulting in histone H3 citrullination at position 2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23131", "l": "4-hydroxybutanoate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57472", "l": "(E)-4-coumarate + UDP-alpha-D-glucose = 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12514", "l": "H2O2 + NH4(+) + oxaloacetate => D-aspartate + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854981", "l": "SHC1 in the RET complex is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72140", "l": "estrone 3-sulfate(in) + H(+)(out) => estrone 3-sulfate(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71366", "l": "17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out) <=> 17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13438", "l": "(E)-cinnamate + UDP-alpha-D-glucose => 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30849", "l": "(2E)-butenoyl-CoA + CO2 + FADH2 => FAD + glutaryl-CoA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45408", "l": "(2E)-dodecenoyl-CoA + H(+) + NADH = dodecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31152", "l": "H2O + L-selenocystathionine => 2-oxobutanoate + L-selenocysteine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35314", "l": "3-hydroxyisoheptadecanoyl-CoA + NADP(+) <=> 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67334", "l": "13-cis-retinoate + 2 H(+) + NADH => 13-cis-retinal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27604", "l": "di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate => (2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635843", "l": "GLI translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940134", "l": "FOLR2 binds FOLA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10838", "l": "demethylsulochrin + NADP(+) => NADPH + O2 + questin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10086", "l": "3-carboxy-cis,cis-muconate + 2 H(+) => 3,4-dihydroxybenzoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42691", "l": "AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide <=> A + ergothioneine + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66642", "l": "diphosphate + koraiol => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.6", "l": "\"acyl-CoA (9+3)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655245", "l": "Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167117", "l": "Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668605", "l": "RAC2:GTP binds NOX2 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60888", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O = (N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42424", "l": "2-methylmaleate + H2O = (2R,3S)-3-methylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25868", "l": "H2O + N(1),N(12)-diacetylspermine + O2 = 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102886", "l": "alpha-chamigrene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> alpha-chamigrene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22887", "l": "glyoxylate + L-methionine <=> 4-methylsulfanyl-2-oxobutanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29384", "l": "dIMP + H2O => 2'-deoxyinosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13197", "l": "H(+) + sulfite + UDP-alpha-D-glucose = H2O + UDP-alpha-D-6-sulfoquinovose", "d": []}, {"i": "EC:3.13.1.1", "l": "\"UDP-sulfoquinovose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047412", "l": "N-(long-chain-acyl)ethanolamine deacylase activity", "d": ["Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanolamine + a fatty acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047352", "l": "adenylylsulfate-ammonia adenylyltransferase activity", "d": ["Catalysis of the reaction: 5'-adenylyl sulfate + NH4 = adenosine 5'-phosphoramidate + 2 H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985591", "l": "SLIT2-bound ROBO1 binds MYO9B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51462", "l": "(9Z)-octadecenoate + L-glutamate => H2O + N-(9Z-octadecenoyl)-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47473", "l": "(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH => (3E)-tetradecenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112271", "l": "The receptor:G-protein complex dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53754", "l": "a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16694", "l": "alpha-pinene oxide => (Z)-2-methyl-5-isopropylhexa-2,5-dienal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-377644", "l": "Release of CSK from SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55999", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004801", "l": "transaldolase activity", "d": ["Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74742", "l": "Phosphorylation of SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20663", "l": "2 D-alanine => D-alanyl-D-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32034", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-curcumene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627072", "l": "RHOQ binds GOPC:CFTR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45748", "l": "(3Z)-hexenoyl-CoA = (2E)-hexenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83788", "l": "Binding of TFIIIC to Type 2 promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37862", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA <=> 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31360", "l": "FMNH2 + nitrilotriacetate + O2 => ammoniodiacetate + FMN + glyoxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74020", "l": "glycine(out) + L-alanine(in) => glycine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54526", "l": "3-hydroxyhexane-2,5-dione + CO2 => acetoacetate + H(+) + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66674", "l": "5,7-dihydroxy-4-methylphthalide + H2O => 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174224", "l": "Dissociation of Cdc20 from APC/C complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64759", "l": "H2O + S-benzyl-L-cysteine <=> benzylthiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66259", "l": "ATP + H(+) + IC-asc-C7 <=> diphosphate + IC-asc-C7-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67638", "l": "dZMP + fumarate => (2S)-2-amino-2'-deoxyadenylo-succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164834", "l": "Enzyme-bound ATP is released (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68722", "l": "26-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623427", "l": "IGFBP1 gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222594", "l": "Mycothiol scavenges nitrosyl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019771", "l": "high-affinity IgG receptor activity", "d": ["Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15191", "l": "CO2 + 2 Fe(II)-[cytochrome c553] + H(+) => 2 Fe(III)-[cytochrome c553] + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71976", "l": "glutathione(out) + 3 Na(+)(out) => glutathione(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20134", "l": "3-(indol-3-yl)lactate + NAD(+) => H(+) + indole-3-pyruvate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73036", "l": "Co(2+)(out) + H(+)(out) => Co(2+)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47130", "l": "AMP + deoxycholoyl-CoA + diphosphate => ATP + CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39964", "l": "2-hexadecanoylglycerol + H2O => glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3595178", "l": "Defective CHSY1 does not transfer GlcA to chondroitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112514", "l": "JAK activation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050271", "l": "S-alkylcysteine lyase activity", "d": ["Catalysis of the reaction: an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH3 + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351901", "l": "Caspase-mediated cleavage of MST3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38152", "l": "carbonyl sulfide + H2O => CO2 + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216051", "l": "Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1 bind laminin-111 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9670673", "l": "FIX is secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033526", "l": "USP9X binds Ub:PEX5S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71788", "l": "2-oxoadipate + O2 => (R)-2-hydroxyglutarate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655142", "l": "RCHY1 binds POLH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937792", "l": "RUNX3 binds SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31129", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol => 3-O-methylgallate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167630", "l": "Formation of Nef CD28 cytoplasmic tail complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73806", "l": "AIR + CO2 => CAIR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47182", "l": "(25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH => (25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193753", "l": "3,7,24THCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432897", "l": "ILK interacts with beta-1 integrin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55479", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25853", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28648", "l": "acetophenone + 2 ATP + H2O + hydrogencarbonate => 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317531", "l": "SREBP1A,1C,2 binds SCAP:INSIG:oxysterol and is retained in the endoplasmic reticulum (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36740", "l": "heptadecasphing-4-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67012", "l": "a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate", "d": []}, {"i": "EC:2.7.7.50", "l": "\"mRNA guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57260", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP = GDP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0070891", "l": "lipoteichoic acid binding", "d": ["Binding to lipoteichoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59148", "l": "ATP + CoA + marinolate C = AMP + diphosphate + marinoloyl-CoA C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788061", "l": "Fibronectin degradation by ADAM8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27965", "l": "myo-inositol + pyrroloquinoline quinone <=> H(+) + pyrroloquinoline quinol + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54835", "l": "a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950398", "l": "CANX dissociates from IL27:EBI3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047081", "l": "3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity", "d": ["Catalysis of the reaction: O2 + NADPH + H+ + 3-hydroxy-2-methylpyridine-5-carboxylate = NADP+ + 2-(acetamidomethylene)succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45960", "l": "24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009025", "l": "tagatose-bisphosphate aldolase activity", "d": ["Catalysis of the reaction: D-tagatose 1,6-diphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614933", "l": "ACEIs bind ACE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9650473", "l": "SERPING1 is secreted (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4615910", "l": "SUMOylation of PCNA with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.11", "l": "\"peptide-methionine (S)-S-oxide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39473", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+) => (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16738", "l": "H(+) + NADH + O2 + toluene => (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73707", "l": "ATP(in) + UDP(out) = ATP(out) + UDP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15134", "l": "H2O + L-glutamate + NAD(+) => 2-oxoglutarate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55381", "l": "a 3alpha-hydroxy bile acid CoA + NAD(+) => a 3-oxo bile acid CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65851", "l": "A + a 3-oxo-Delta(1)-steroid + H2O <=> a steroid 1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30465", "l": "(+)-alpha-santalene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696275", "l": "RND2 binds GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731931", "l": "EDNRA binds selective ERAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101006", "l": "protein histidine phosphatase activity", "d": ["Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610732", "l": "GSK3 phosphorylates p-GLI3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22678", "l": "7(1)-hydroxychlorophyllide a + H2O + NADP(+) => chlorophyllide a + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177479", "l": "Axonal transport of NGF:Trk complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72358", "l": "dehydroepiandrosterone 3-sulfate(out) + glutarate(in) <=> dehydroepiandrosterone 3-sulfate(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71164", "l": "H(+)(in) + L-alanine(out) + Na(+)(out) => H(+)(out) + L-alanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20881", "l": "10-hydroxydecanoate + NAD(+) => 10-oxodecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396399", "l": "Fibrillins bind BMPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42720", "l": "S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.166", "l": "\"23S rRNA (uridine(2552)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70632", "l": "H2O + N(6)-decanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-decanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034870", "l": "pinacolone 5-monooxygenase activity", "d": ["Catalysis of the reaction: 2,2-dimethyl-3-pentanone + 1/2 O2 = 1-hydroxy-4,4-dimethylpentan-3-one."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63788", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61617", "l": "H(+) + L-proline betaine + NADH + O2 => formaldehyde + H2O + N-methyl-L-proline + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-422454", "l": "Polysialylation of NCAM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59792", "l": "H2O + NADP(+) + yersinopine = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39657", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047860", "l": "diiodophenylpyruvate reductase activity", "d": ["Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191656", "l": "Closure of gap junction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876230", "l": "InlB:MET dimer trans-autophophorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12056", "l": "D-erythrose 4-phosphate + H2O + NAD(+) = 4-phospho-D-erythronate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.72", "l": "\"erythrose-4-phosphate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731047", "l": "SARS-CoV-1 6 binds to NMI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.1", "l": "\"steroid Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11995", "l": "L-pipecolate + O2 <=> H(+) + H2O2 + L-1-piperideine-6-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209218", "l": "Phosphorylated DL/DIF dimer activates transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53086", "l": "[(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP => [(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216045", "l": "Collagen type I binds integrin alpha11beta1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705729", "l": "SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080019", "l": "alcohol-forming very long-chain fatty acyl-CoA reductase activity", "d": ["Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. A very long chain fatty acid (VLCFA) is a fatty acid with an aliphatic tail of 22 or more carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65015", "l": "decanoyl-AMP + holo-[ACP] <=> AMP + decanoyl-[ACP] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68789", "l": "(2Z,6Z)-farnesyl diphosphate => (Z)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54905", "l": "(2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH => (9Z)-hexadecenoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14656", "l": "a nucleoside 3',5'-cyclic phosphate + H2O <=> a nucleoside 5'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700193", "l": "ALK mutants phosphorylate SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72365", "l": "chloride(in) + hydrogencarbonate(out) => chloride(out) + hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690669", "l": "CD22 binds itself to form homo-oligomers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209074", "l": "WG, FZ and ARR bind to each other (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27304", "l": "3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => 7-chloro-L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373087", "l": "Receptor CCR6 binds CCL20 ligand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44100", "l": "H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69616", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0047598", "l": "7-dehydrocholesterol reductase activity", "d": ["Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77608", "l": "Binding of A1CF to stem-looped RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952128", "l": "RUNX3 binds TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44182", "l": "(2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73774", "l": "O2 + preechinulin + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + neoechinulin A + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61500", "l": "delphinidin + UDP-alpha-D-glucose = delphinidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452894", "l": "Expression of SOX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73577", "l": "CAD hexamer transforms L-Gln to CAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42835", "l": "(2E)-octenal + H(+) + pyruvate <=> (S)-3-acetyloctanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708275", "l": "PDE4A binds PDE4A inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102287", "l": "4-coumaroylhexanoylmethane synthase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + 3-oxooctanoyl-CoA + H2O <=> 4-coumaroylhexanoylmethane + 2 coenzyme A + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57531", "l": "a 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O <=> a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21482", "l": "5-hydroxy-2-furoyl-CoA + AH2 + H(+) => 2-furoyl-CoA + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12643", "l": "3-phosphooxypyruvate + H(+) + NADH => (2R)-3-phosphoglycerate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66987", "l": "3-methylbutanoyl-CoA + H2O <=> CoA + H(+) + isovalerate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031624", "l": "ARC gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66713", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047677", "l": "arachidonate 8(R)-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (5Z,8R,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24132", "l": "UDP-alpha-D-galactose = UDP-alpha-D-galactofuranose", "d": []}, {"i": "EC:5.4.99.9", "l": "\"UDP-galactopyranose mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28853", "l": "melibiose(out) + Na(+)(out) => melibiose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48377", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose => a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58626", "l": "dodecanamide + glyoxylate => N-dodecanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592436", "l": "Initial activation of proMMP9 by MMPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-844438", "l": "NLRP1 oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71219", "l": "2 Na(+)(out) + nitrate(out) = 2 Na(+)(in) + nitrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41764", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E)) = CMP + ganglioside GT3 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32051", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = adenosine 5'-tetraphosphate + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61318", "l": "germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30372", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O => (-)-geosmin + acetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20008", "l": "an alpha-D-glucuronoside + H2O <=> an alcohol + D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24588", "l": "ATP + D-arabinose = ADP + D-arabinose 5-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.54", "l": "\"D-arabinokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9007447", "l": "E2F6 forms the PRC1L4 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69299", "l": "CDT1 binds geminin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59250", "l": "(E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174808", "l": "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70658", "l": "H(+)(in) + sarcosine(in) <=> H(+)(out) + sarcosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26221", "l": "abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.145", "l": "\"abieta-7,13-dien-18-ol hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29966", "l": "H(+)(in) + inosine(in) <=> H(+)(out) + inosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038047", "l": "morphine receptor activity", "d": ["Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25430", "l": "ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate => ATP + N-acetyl-D-hexosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388814", "l": "Grb2 binds CD28 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21614", "l": "2-dehydro-3-deoxy-D-gluconate + H2O => D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140811", "l": "histone H2AR3 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone 2A L-arginyl (position 3)= histone 2A L-citrullyl (position 3) + NH4+, resulting in histone H2A citrullination at position 3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847537", "l": "RAB43:GTP binds USP8NL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22221", "l": "ent-copalyl diphosphate => diphosphate + ent-kaur-16-ene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247922", "l": "GGCT transforms gGluCys to OPRO (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102794", "l": "cinnamaldehyde:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: cinnamaldehyde + O2 + H2O = H+ + trans-cinnamate + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32127", "l": "2-oxoglutarate + L-proline + O2 = cis-4-hydroxy-L-proline + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.56", "l": "\"L-proline cis-4-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.4.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798031", "l": "TP53 stimulates BTG2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33775", "l": "a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46876", "l": "[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate = [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.33", "l": "\"mannuronan synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67788", "l": "2 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a cardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56017", "l": "H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674093", "l": "PDGFRs bind type I TKI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33230", "l": "(E)-4-coumarate + H(+) <=> 4-hydroxystyrene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70102", "l": "H(+) + o-quinone methide + peniphenone D <=> penilactone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61713", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine => 2 Fe(III)-[cytochrome b5] + H2O + N(delta)-methyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192704", "l": "Synthesis of PB1-F2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27571", "l": "ATP + D-glycero-alpha-D-manno-heptose 7-phosphate => ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875591", "l": "DOCK7 activates RAC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201443", "l": "Type II receptor phosphorylates type I receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31710", "l": "2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30561", "l": "guanosine + H(+) + triphosphate => GTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419003", "l": "Interaction of Nectins with Afadin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28680", "l": "3-demethylubiquinol-8 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34941", "l": "menaquinol-8 + selenate => H2O + menaquinone-8 + selenite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71814", "l": "3,3',5-triiodo-L-thyronine(out) <=> 3,3',5-triiodo-L-thyronine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46173", "l": "ATP + butanoate + CoA => AMP + butanoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13011", "l": "formate + H(+) + L-kynurenine => H2O + N-formyl-L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316349", "l": "RALA:GTP binds MYO1C:CALM1 and activates MYO1C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61777", "l": "rebaudioside D + UDP-alpha-D-glucose => H(+) + rebaudioside M + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49229", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) => diphosphate + geranylgeranyl-bacteriochlorophyllide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73672", "l": "ADP(out) + diphosphate(in) => ADP(in) + diphosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18995", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848250", "l": "ACBD6 binds LCFA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11006", "l": "catechol + CO2 + H2O + NAD(+) => 2 H(+) + NADH + O2 + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187575", "l": "Ubiquitination of phospho-p27/p21 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218821", "l": "PDK1 phosphorylates PKC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49398", "l": "20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52783", "l": "H2O + S-(hercyn-2-yl)-L-cysteine S-oxide <=> 2-sulfenohercynine + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33506", "l": "ATP + H2O + itraconazole(in) <=> ADP + H(+) + itraconazole(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21894", "l": "D-arabinono-1,4-lactone + H(+) + NADPH => D-arabinose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-380586", "l": "loading of Serotonin in synaptic vesicles (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110475", "l": "DAkt1-mediated phosphorylation inactivates DFOXO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350651", "l": "Caspase-mediated cleavage of MASK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69720", "l": "(indol-3-yl)acetate + ATP + H(+) => (indol-3-yl)acetyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9733545", "l": "Bile salts and acids bind ALB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61069", "l": "acetyl-CoA + horhammericine => 19-O-acetylhorhammericine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44071", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28742", "l": "Cd(2+)(in) + H(+)(out) <=> Cd(2+)(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42224", "l": "A + testosterone = AH2 + androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48242", "l": "CMP + ganglioside GT1b + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37314", "l": "ATP + glycyl-L-glutamine(out) + H2O <=> ADP + glycyl-L-glutamine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53541", "l": "(13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15210", "l": "(2R,3R)-tartrate + NAD(+) => 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46302", "l": "2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29850", "l": "(2E)-tetradecenoyl-CoA <=> (3Z)-tetradecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035275", "l": "dibutyl phthalate binding", "d": ["Binding to dibutyl phthalate, C(16)H(22)O(4)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050613", "l": "delta14-sterol reductase activity", "d": ["Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18974", "l": "2-oxoglutarate + deacetoxyvindoline + O2 => 4-O-deacetylvindoline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76061", "l": "H(+) + N-methylheliamine + S-adenosyl-L-homocysteine => heliamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23030", "l": "acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein] => malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015109", "l": "chromate transmembrane transporter activity", "d": ["Enables the transfer of chromate from one side of a membrane to the other. Chromate is the anion of chromic acid, H2CrO4 (aq) or CrO3."]}, {"i": "RHEA:32819", "l": "chromate(in) = chromate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624800", "l": "CDK1 phosphorylates LBR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350598", "l": "Arginine<=>Agmatine+CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53229", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34311", "l": "4-nitrocatechol + NADH + O2 = 2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047189", "l": "2,3-diaminopropionate N-oxalyltransferase activity", "d": ["Catalysis of the reaction: 3-amino-L-alanine + oxalyl-CoA = N(3)-oxalyl-L-2,3-diaminopropanoate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15255", "l": "CO2 + itaconate => cis-aconitate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40779", "l": "2-aminopentanenitrile + H(+) + 2 H2O = L-2-aminopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46162", "l": "a quinol + NAD(+) => a quinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799761", "l": "TP53 binds PPP1R13L (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60371", "l": "urate(out) <=> urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034537", "l": "2-hydroxy-3-methylbenzalpyruvate hydratase-aldolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-3-methylbenzalpyruvate + H2O = pyruvate + 3-methylsalicylaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3321883", "l": "MSL acetylates histone H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29012", "l": "2-oxoglutarate(in) + H(+)(in) => 2-oxoglutarate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-990489", "l": "Kinesin-13 is a dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193650", "l": "p75NTR binds to NADE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62540", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabain = dihydroouabain + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667914", "l": "ALK binds ligand midkine (MDK) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024973", "l": "Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23297", "l": "aceneuramate => N-acetyl-D-mannosamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48151", "l": "ganglioside GT1b (d18:1(4E)/18:0) + H2O <=> ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295613", "l": "SPRY2 binds GRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42956", "l": "cytidine(38) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.204", "l": "\"tRNA (cytosine(38)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24376", "l": "apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin = AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]", "d": []}, {"i": "EC:6.3.4.11", "l": "\"biotin--[methylcrotonoyl-CoA-carboxylase] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45212", "l": "acetyl-CoA + Co(I)-[corrinoid Fe-S protein] + H(+) = CO + CoA + methyl-Co(III)-[corrinoid Fe-S protein]", "d": []}, {"i": "EC:2.3.1.169", "l": "\"CO-methylating acetyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19713", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.15", "l": "\"arachidonate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54172", "l": "H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+) = 2''-O-acyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66618", "l": "Mg(2+)(out) + 2 Na(+)(in) => Mg(2+)(in) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35977", "l": "A + CO2 + H2O + succinate + verruculogen => 2-oxoglutarate + AH2 + fumitremorgin B + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75216", "l": "beta-L-fucose + NADP(+) => H(+) + L-fucono-1,5-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42146", "l": "a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73303", "l": "H(+)(in) + oxaloacetate(out) + phosphate(in) = H(+)(out) + oxaloacetate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864737", "l": "TFAP2A homodimer binds the VEGFA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696947", "l": "USP47 deubiquitinates POLB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676599", "l": "sBAFF trimer binds BAFFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22171", "l": "UDP-alpha-D-glucose <=> UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627775", "l": "Autophosphorylation of PAK1,2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381668", "l": "cAMP activates EPAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36107", "l": "gibberellin A4 + S-adenosyl-L-methionine = O-methyl gibberellin A4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59599", "l": "H2O + kynuramine + O2 <=> 3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5622129", "l": "FABP5 binds atRA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74262", "l": "H2O + L-homoseryl-tRNA(Lys) <=> H(+) + L-homoserine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60832", "l": "a 5'-end triphospho-guanosine in mRNA + H2O = a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211206", "l": "Translocation of DFF to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74439", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54011", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17357", "l": "O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'", "d": []}, {"i": "EC:1.8.3.2", "l": "\"thiol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.61", "l": "\"feruloyl-CoA hydratase/lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22822", "l": "3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416530", "l": "FFAR1:FFAR1 ligands activates Gq (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17858", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37860", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA => 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12302", "l": "3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine => S-adenosyl-L-methionine + uridine(47) in tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863472", "l": "DAB2 binds LRP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688786", "l": "ATXN3 binds RAD23 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008239", "l": "dipeptidyl-peptidase activity", "d": ["Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29218", "l": "fumarate + menaquinol-8 <=> menaquinone-8 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296244", "l": "SUCNR1 binds SUCCA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2301205", "l": "SETD8 monomethylates histone H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018807", "l": "RAC3 GDIs block activation of RAC3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54496", "l": "ent-copalyl diphosphate = diphosphate + ent-atiserene", "d": []}, {"i": "EC:4.2.3.185", "l": "\"ent-atiserene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240766", "l": "E2F1/2/3:DP1/2 binds SUZ12 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165047", "l": "Translocation of nuclear RNA transport complex to cytoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004769", "l": "steroid delta-isomerase activity", "d": ["Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0005520", "l": "insulin-like growth factor binding", "d": ["Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17613", "l": "NAD(+) + scyllo-inositol = H(+) + NADH + scyllo-inosose", "d": []}, {"i": "EC:1.1.1.370", "l": "\"scyllo-inositol 2-dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694583", "l": "ABHD4 hydrolyses NAPE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56424", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29053", "l": "2 H(+)(out) + menaquinol-8 => 2 H(+)(in) + H2 + menaquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46581", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 => 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25936", "l": "8-methylquinoline + A + H2O = 8-methylquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.21", "l": "\"keratan sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32044", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => 2 ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67085", "l": "ATP + H2O + hexacosanoate(in) => ADP + H(+) + hexacosanoate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351849", "l": "Caspase-mediated cleavage of Etk (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166542", "l": "beta-NGF dimer binds to TrkA receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22433", "l": "a (3S)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032478", "l": "EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694527", "l": "Loss of SAR1B GTPase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433374", "l": "Processing of SCF isoform 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39441", "l": "(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34265", "l": "diphosphate + fumigaclavine C => dimethylallyl diphosphate + fumigaclavine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68954", "l": "Mcm2-7 is phosphorylated by DDK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66104", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27327", "l": "3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.44", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429860", "l": "DCP1-DCP2 complex decaps mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030753", "l": "8-hydroxyfuranocoumarin 8-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin. Xanthotoxol is also known as 8-hydroxyfuranocoumarin and xanthotoxin as 8-methoxyfuranocoumarin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14902", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => casbene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201637", "l": "Caspase-mediated cleavage of plectin-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416683", "l": "SEMA3E binds to PLXND1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672177", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031773", "l": "kisspeptin receptor binding", "d": ["Binding to a kisspeptin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.6", "l": "\"AMP deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47466", "l": "(2E,5Z)-tetradecadienoyl-CoA => (3E,5Z)-tetradecadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49010", "l": "aurachin C epoxide + H2O + NADP(+) => aurachin C + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45281", "l": "12-(phosphooxy)octadecanoate + H2O => 12-hydroxyoctadecanoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621370", "l": "SYK autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2509827", "l": "ITPA hydrolyses ITP to IMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112437", "l": "Formation of NELF complex  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62207", "l": "1-propanol + 2 Fe(III)-[cytochrome c] <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67052", "l": "AH2 + asnovolin J + O2 = A + asnovolin A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.19", "l": "\"3-phenylpropanoate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28799", "l": "H2O + L-prolinylglycine = glycine + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71654", "l": "a thymidine in DNA + NAD(+) <=> an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381500", "l": "Cathepsin G proteolyzes IGF:IGFBP3:ALS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797100", "l": "CCNK binds CDK13 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48481", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose => 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23041", "l": "2-oxobutanoate + acetyl-CoA + H2O => (R)-2-ethylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12791", "l": "an aldose + H(+) + NADPH => an alditol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28325", "l": "UDP-alpha-D-glucuronate + wogonin <=> UDP + wogonin 7-O-beta-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373075", "l": "Metabotropic glutamate receptors bind glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43813", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0140414", "l": "phosphopantetheine-dependent carrier activity", "d": ["Binding a substrate via a thioester at the terminal thiol of a covalentely linked phosphopantetheine prosthetic group and mediating protein-protein interactions with cognate enzymes for processing or offloading of the thiol-bound substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371527", "l": "HSF1 trimer translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731924", "l": "EDNRA binds EDNs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432129", "l": "FGR binds and phosphorylates LRP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25882", "l": "2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+) => 2 L-dopa + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617896", "l": "Retinoic acid activates HOXD4 chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39033", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61802", "l": "AMP + diphosphate + L-alanyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794347", "l": "Homer1,2,3 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034560", "l": "bisphenol A hydroxylase A activity", "d": ["Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018684", "l": "2,5-diketocamphane 1,2-monooxygenase", "d": ["Catalysis of the reaction: 1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682011", "l": "LC3 binds ATG7 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38657", "l": "D-glucose + tulipalin B => 6-tuliposide B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58497", "l": "choline + H(+) + NADH + O2 => glycolaldehyde + H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009558", "l": "IL34 dimer binds SDC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873926", "l": "IFNG dimer binds IFNGR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16206", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] => N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45595", "l": "H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66908", "l": "acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine = 9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0008187", "l": "poly-pyrimidine tract binding", "d": ["Binding to a stretch of pyrimidines (cytosine or uracil) in an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57150", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65377", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003789", "l": "actin filament severing activity", "d": ["Binding to an actin subunit and promoting its dissociation from an actin filament by a local change in actin subunit conformation and orientation, and severing of filaments."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139920", "l": "Translocation of tBID to mitochondria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28891", "l": "H(+)(in) + putrescine(in) = H(+)(out) + putrescine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462041", "l": "HNP1-4 are released into phagocytic vacuoles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052607", "l": "7-hydroxy-chlorophyllide a oxygenase activity", "d": ["Catalysis of the reaction: 7-hydroxychlorophyllide a + NADPH + O2 + H+ = chlorophyllide b + NADP+ + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47672", "l": "H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) = 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64603", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209536", "l": "IkB is ubiquitinated and degraded (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38325", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + glycerol => 2 1-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203611", "l": "N-myristoylation of eNOS (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102080", "l": "phenylacetyl-coenzyme A:glycine N-acyltransferase activity", "d": ["Catalysis of the reaction: phenylacetyl-CoA + glycine <=> H+ + phenylacetylglycine + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482770", "l": "Release of platelet secretory granule components (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50660", "l": "3-(3-methylsulfanyl)propylmalate = 2-(2-methylsulfanyl)propylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199456", "l": "PTEN dephosphorylates PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617479", "l": "HOXA2 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28037", "l": "[thioredoxin]-disulfide + dADP + H2O <=> [thioredoxin]-dithiol + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28818", "l": "4-hydroxybenzoate(in) + H(+)(out) <=> 4-hydroxybenzoate(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45481", "l": "gamma-hexachlorocyclohexane => (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201685", "l": "Beta-catenin is released from the destruction complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417829", "l": "P2RY12 binds ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30155", "l": "FADH2 + 2 Fe(3+) = FAD + 2 Fe(2+) + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19045", "l": "acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.21", "l": "\"(R)-citramalate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55620", "l": "a carotenoid psi-end group = a carotenoid beta-end derivative", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033786", "l": "heptose-1-phosphate adenylyltransferase activity", "d": ["Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glycero-D-manno-heptose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42508", "l": "6-acetamido-2-oxohexanoate + H2O + NAD(+) = 5-acetamidopentanoate + CO2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28938", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate <=> oxaloacetate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5622129", "l": "FABP5 binds atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781899", "l": "USP13 binds SIAH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357432", "l": "AXL binds SRC-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005053", "l": "peroxisome matrix targeting signal-2 binding", "d": ["Binding to a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73757", "l": "Binding of RRN3 to RNA Polymerase I (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29278", "l": "L-isoleucine(in) + Na(+)(in) <=> L-isoleucine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140036", "l": "ubiquitin-dependent protein binding", "d": ["Binding to a protein upon ubiquitination of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17607", "l": "ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate => ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754775", "l": "SARS-CoV-2 M protein binds MAP1LC3B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47743", "l": "1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate <=> CO2 + demethylphylloquinone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32224", "l": "(6S)-NADHX + ADP => AMP + H(+) + NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72406", "l": "2-oxoglutarate(out) + urate(in) <=> 2-oxoglutarate(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0001016", "l": "RNA polymerase III transcription regulatory region sequence-specific DNA binding", "d": ["Binding to a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-844447", "l": "NLRP1 senses MDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68226", "l": "CO2 + H2O + kainate lactone + succinate => 2-oxoglutarate + H(+) + O2 + prekainate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050242", "l": "pyruvate, phosphate dikinase activity", "d": ["Catalysis of the reaction: ATP + phosphate + pyruvate = AMP + diphosphate + 2 H+ + phosphoenolpyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71724", "l": "H(+)(out) + L-alanyl-L-leucyl-L-alanine(out) => H(+)(in) + L-alanyl-L-leucyl-L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798743", "l": "Exocytosis of secretory granule membrane proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32349", "l": "3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + tricetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187678", "l": "ADCYAP1(2-742) binds ADCYAP1R1 and NTRK1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53710", "l": "(2E,4Z)-decadienoyl-CoA + H(+) + NADPH => (2E)-decenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74719", "l": "myricetin + S-adenosyl-L-methionine = 7-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.-", "l": "\"Endoribonucleases producing 5'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420977", "l": "Ca permeable AMPA receptor ligand binding (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11917", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) => 15-oxoprostaglandin E2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53966", "l": "gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP] => 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250220", "l": "Homodimerization of ERBB4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38282", "l": "(3R)-citramalate + succinyl-CoA <=> (3R)-citramalyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-593690", "l": "Phosphorylation of PLCgamma by Netrin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69967", "l": "Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211960", "l": "CYP2U1 19-hydroxylates ARA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875816", "l": "STAT3 binds activated MET receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37293", "l": "L-alanine + L-leucine => H2O + L-alanyl-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55925", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] => albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64457", "l": "L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710354", "l": "GSDME (1-270) binds cardiolipin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9704297", "l": "CHRM2 binds CHRM2 antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74431", "l": "1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35877", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67074", "l": "a very long-chain fatty acid + CoA + H(+) => a very long-chain fatty acyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983158", "l": "Trimming of peptides in ER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49938", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58603", "l": "2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35007", "l": "D-fucose(in) = D-fucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0015278", "l": "calcium-release channel activity", "d": ["Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts."]}, {"i": "REACT:R-HSA-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114684", "l": "Phosphorylation of Syntaxin-4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60352", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone + O2 = CO + H(+) + N-octanoylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53222", "l": "6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13579", "l": "a long chain fatty alcohol + a long-chain fatty acid + H(+) => a wax ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653936", "l": "Formation of Ragulator complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605717", "l": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905594", "l": "resveratrol binding", "d": ["Binding to resveratrol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380586", "l": "loading of Serotonin in synaptic vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32353", "l": "3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine => 3 S-adenosyl-L-methionine + tricetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190256", "l": "FGFR1c binds to FGF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70087", "l": "methanol + o-quinone methide = hydroxyclavatol methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12277", "l": "3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50230", "l": "benzene-1,2,4-triol + FAD + H(+) + H2O => FADH2 + O2 + resorcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64934", "l": "dGMP + 2 H(+) + 2 phosphate => dGTP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60742", "l": "(S)-(-)-citronellate + 2 H(+) + NADPH => (S)-(-)-citronellal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8948757", "l": "AKT phosphorylates MKRN1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0005381", "l": "iron ion transmembrane transporter activity", "d": ["Enables the transfer of iron (Fe) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66028", "l": "AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine = (5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.379", "l": "\"[methyl coenzyme M reductase]-L-arginine C-5-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35175", "l": "novobiocin(in) = novobiocin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39858", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol <=> a triacyl-sn-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65193", "l": "2 2-oxoglutarate + 2 O2 + preaustinoid A => berkeleytrione + 2 CO2 + H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64777", "l": "3-sulfanylpentan-1-ol-L-cysteine => 2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035167", "l": "NR1H2,3 binds the EEPD1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54096", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14042", "l": "(R)-vicianin + H2O => mandelonitrile + vicianose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17430", "l": "NAD(+) + trans-4-hydroxycyclohexanecarboxylate => 4-oxocyclohexanecarboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194678", "l": "CYP51A1 demethylates LNSOL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62020", "l": "H2O + sitosteryl 3-beta-D-glucoside = D-glucose + sitosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54458", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71284", "l": "chloride(out) + L-glutamine(out) + 2 Na(+)(out) => chloride(in) + L-glutamine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29379", "l": "dGMP + H2O = 2'-deoxyguanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.16", "l": "\"cathepsin H\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18652", "l": "D-galactonate <=> 2-dehydro-3-deoxy-D-galactonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17269", "l": "macrocin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + tylosin", "d": []}, {"i": "EC:2.1.1.101", "l": "\"macrocin O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45270", "l": "4',4'-dihydroxyechinenone + A + H2O => 4'-hydroxyechinenone + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66859", "l": "(2E)-geranyl diphosphate + 3 isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848818", "l": "PTK6 phosphorylates CBL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18347", "l": "a cis-alkene + CO2 => a cis-3-alkyl-4-alkyloxetan-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42527", "l": "uridine(1911/1915/1917) in 23S rRNA <=> pseudouridine(1911/1915/1917) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58490", "l": "H2O + NAD(+) + succinate semialdehyde + trimethylamine => 4-(trimethylamino)butanoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209815", "l": "Tyrosine is monoiodinated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033828", "l": "glucosylglycerol-phosphate synthase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + ADP-glucose = 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050041", "l": "lactate aldolase activity", "d": ["Catalysis of the reaction: (S)-lactate = acetaldehyde + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73577", "l": "CAD hexamer transforms L-Gln to CAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25140", "l": "(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) => 3-amino-2-oxopropyl phosphate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48428", "l": "1-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29327", "l": "(S)-malate(in) + succinate(out) = (S)-malate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62487", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211904", "l": "CYP4F12 18-hydroxylates ARA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63735", "l": "UDP-alpha-D-glucuronate + zolasartan <=> UDP + zolarsartan O-beta-D-glucuronoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70316", "l": "beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75862", "l": "Fall Back to Closed Pre-initiation Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66605", "l": "a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O => a 2'-deoxyuridine in double-stranded DNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0052619", "l": "coenzyme F420-1:gamma-L-glutamate ligase activity", "d": ["Catalysis of the reaction: GTP + L-glutamate + factor gamma-F420-1 = GDP + H+ + factor gamma-F420-2 + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54486", "l": "1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47952", "l": "[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O = [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)", "d": []}, {"i": "EC:3.5.1.119", "l": "\"Pup amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46272", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17018", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA => (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448678", "l": "CTSG cleaves CASP1(1-404) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14152", "l": "luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43738", "l": "H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine => adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57978", "l": "(20S)-ginsenoside C-K + H(+) + UDP => (20S)-protopanaxadiol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690493", "l": "RHOB binds effectors on endosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21000", "l": "1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene", "d": []}, {"i": "EC:1.97.1.2", "l": "\"pyrogallol hydroxytransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169921", "l": "Glycosylation and Folding of HA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033798", "l": "thyroxine 5-deiodinase activity", "d": ["Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25025", "l": "H(+) + H2O + S-methyl-5'-thioadenosine = NH4(+) + S-methyl-5'-thioinosine", "d": []}, {"i": "EC:3.5.4.31", "l": "\"S-methyl-5'-thioadenosine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018831", "l": "5-chloro-1,2,4-trihydroxybenzene dechlorinase activity", "d": ["Catalysis of the reaction: 5-chloro-1,2,4-trihydroxybenzene = Cl- + H+ + 2-hydroxy-1,4-benzoquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72398", "l": "2 chloride(out) + K(+)(out) + Na(+)(out) <=> 2 chloride(in) + K(+)(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17567", "l": "1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine => myo-inositol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870466", "l": "RGGT:CHM binds RABs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31753", "l": "7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45371", "l": "H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173771", "l": "Formation of RTC (Reverse Transcription Complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814554", "l": "Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44609", "l": "3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43763", "l": "acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682709", "l": "LGI4 binds ADAM22,23,11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40848", "l": "eicosanoyl-CoA + FAD + H(+) => (2E)-eicosenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168376", "l": "STIM1 oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016847", "l": "1-aminocyclopropane-1-carboxylate synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14492", "l": "a nucleoside 2',3'-cyclic phosphate + H2O <=> a nucleoside 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73074", "l": "apigenin + S-adenosyl-L-methionine <=> genkwanin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54023", "l": "L-lysyl-[protein] + propanoyl-CoA <=> CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19184", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74673", "l": "UDP-beta-L-arabinopyranose(out) + UMP(in) => UDP-beta-L-arabinopyranose(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858428", "l": "FCAMR binds IgA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42914", "l": "5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49140", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:4.2.1.164", "l": "\"dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34922", "l": "thiamine(in) <=> thiamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871260", "l": "YAP1 binds TEAD2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14280", "l": "(S)-lactaldehyde + H2O + NAD(+) <=> (S)-lactate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67138", "l": "3-hydroxypropanoyl-CoA + ADP + phosphate => 3-hydroxypropanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33884", "l": "2-deoxy-scyllo-inosamine + NAD(+) => 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39680", "l": "(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72306", "l": "L-glutamate(in) + L-thyroxine(out) <=> L-glutamate(out) + L-thyroxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48444", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol = a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61719", "l": "ATP + D-galactofuranose(out) + H2O <=> ADP + D-galactofuranose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9637589", "l": "MmpL7 transports PDIM from the cytosol to the cell wall (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31228", "l": "di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine => di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19175", "l": "(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) => H(+) + NADH + naphthalene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213239", "l": "Formation of MHC II alpha beta heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23458", "l": "A + crepenynate + 2 H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983424", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50280", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202127", "l": "eNOS synthesizes NO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51228", "l": "17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate = 17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674018", "l": "BRAP binds RAS:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62494", "l": "AMP + diphosphate + L-arginyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21235", "l": "L-histidine <=> NH4(+) + trans-urocanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63573", "l": "H2O + neurotensin-(1-8) => L-arginine + neurotensin-(1-7)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62756", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30693", "l": "formaldehyde + 2 H2O => H2O2 + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9732629", "l": "PPARG binds PPARG agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111919", "l": "PKA phosphorylates CREB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938231", "l": "RUNX1:CBFB binds CREBBP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420661", "l": "Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54043", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (3E,7E)-dolathalia-3,7,11-triene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793275", "l": "CMVPP65 binds NCR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20831", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19499", "l": "beta-alanine + CO2 => H(+) + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031709", "l": "gastrin-releasing peptide receptor binding", "d": ["Binding to a gastrin-releasing peptide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69958", "l": "Ca(2+)(in) + 3 Na(+)(out) <=> Ca(2+)(out) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14509", "l": "2-oxoglutarate + mugineate + O2 = 3-epihydroxymugineate + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49271", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213239", "l": "Formation of MHC II alpha beta heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62007", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050897", "l": "cobalt ion binding", "d": ["Binding to a cobalt ion (Co)."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0046870", "l": "cadmium ion binding", "d": ["Binding to a cadmium ion (Cd)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13690", "l": "diphosphate + glycerol => glycerol 1-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218906", "l": "RIPK3 phosphorylates MLKL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.4", "l": "\"nicotine hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17657", "l": "an acyl-CoA + dihydroxyacetone phosphate = a 1-acylglycerone 3-phosphate + CoA", "d": []}, {"i": "EC:2.3.1.42", "l": "\"glycerone-phosphate O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13478", "l": "H2O + L-tryptophan + NADP(+) => H(+) + indole-3-pyruvate + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45691", "l": "N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) <=> N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619478", "l": "CAMKK2 phosphorylates AMPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22065", "l": "5alpha-ergosta-7,22-diene-3beta,5-diol => ergosterol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211950", "l": "CYP24A1 24-hydroxylates CTL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013974", "l": "Auto-ubiquitination of TRAF3 within activated TLR3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632182", "l": "PRMT1 methylates ESRs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49079", "l": "dibenzothiophene + FMNH2 + O2 <=> dibenzothiophene 5-oxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031772", "l": "type 2 orexin receptor binding", "d": ["Binding to a type 2 orexin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54589", "l": "S-adenosyl-L-methionine + uridine in 25S rRNA => H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49101", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine => 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626816", "l": "PIN1 binds p-S345-NCF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785607", "l": "FANCM binds FAAP24 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57751", "l": "2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH <=> C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879222", "l": "MDP:NLRP1 binds ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70732", "l": "4-aminobutanoate(out) + chloride(out) + 3 Na(+)(out) => 4-aminobutanoate(in) + chloride(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35078", "l": "doxorubicin(in) + H(+)(out) <=> doxorubicin(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033520", "l": "TYSND1 cleaves TYSND1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22226", "l": "1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O => 3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14110", "l": "L-proline + NADP(+) => 1-pyrroline-5-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49710", "l": "H(+) + isonocardicin C + S-methyl-5'-thioadenosine => nocardicin G + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54470", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate => 1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685838", "l": "CX3 complex binds D-loop structures (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799431", "l": "TP53 binds HIPK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917693", "l": "ESCRT Disassembly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45326", "l": "H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine => H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62626", "l": "[glutaredoxin]-disulfide + an alcohol + H2O => [glutaredoxin]-dithiol + a hydroperoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2974731", "l": "Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48651", "l": "lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005464", "l": "UDP-xylose transmembrane transporter activity", "d": ["Enables the transfer of UDP-xylose from one side of a membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate."]}, {"i": "REACT:R-HSA-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73388", "l": "H(+)(in) + malonate(out) + phosphate(in) => H(+)(out) + malonate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60329", "l": "L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64089", "l": "acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA => 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37093", "l": "3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA => (8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25099", "l": "ATP + UDP => ADP + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14293", "l": "D-glucose + NAD(+) = D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32538", "l": "(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O <=> 4-hydroxy-2-oxohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35176", "l": "novobiocin(in) => novobiocin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56409", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159773", "l": "Furin cleaves pro-protein S to protein S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "44.124727253861252", "identifiers": [{"i": "GO:0004888", "l": "transmembrane signaling receptor activity", "d": ["Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction."]}, {"i": "REACT:R-HSA-193672", "l": "Sphingomyelinase is activated by the NGF:p75NTR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56660", "l": "7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62227", "l": "H(+) + NADPH + neopatulin <=> (E)-ascladiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58792", "l": "ATP + Fe(III)-petrobactin(out) + H2O = ADP + Fe(III)-petrobactin(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41509", "l": "L-ornithine + NADPH + O2 => H2O + N(5)-hydroxy-L-ornithine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12984", "l": "H2O + O2 + S-sulfanylglutathione <=> glutathione + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733960", "l": "Bile salts and acids dissociate from ALB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53806", "l": "allodeoxycholate + ursodeoxycholoyl-CoA => allodeoxycholoyl-CoA + ursodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11835", "l": "(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) <=> H(+) + NADH + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31036", "l": "arabidiol => (S)-2,3-epoxysqualene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.777964009505382", "identifiers": [{"i": "GO:0001067", "l": "transcription regulatory region nucleic acid binding", "d": ["Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34973", "l": "Fe(3+)(out) => Fe(3+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37192", "l": "2',3'-cyclophospho-AMP + H2O => adenosine 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034788", "l": "2,3-dihydroxy-2'-carboxybiphenyl 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxy-2'-carboxybiphenyl + O2 = 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55471", "l": "11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22868", "l": "3-chloro-L-alanine + thioglycolate = chloride + H(+) + S-carboxymethyl-L-cysteine", "d": []}, {"i": "EC:4.5.1.5", "l": "\"S-carboxymethylcysteine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1977959", "l": "ERBB4 forms heterodimers with EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53038", "l": "4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45179", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684096", "l": "CDK2 phosphorylates RBBP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389083", "l": "Autophosphorylation of PDGF alpha receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448673", "l": "Formation of caspase-1 p10/p20 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11672", "l": "chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate", "d": []}, {"i": "EC:2.6.1.85", "l": "\"aminodeoxychorismate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25743", "l": "H(+) + N,N-dihydroxy-L-pentahomomethionine = (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59555", "l": "N,N',N'',N'''-tetraacetylchitotetraose + O2 <=> H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64572", "l": "isopentenyl diphosphate + neryl diphosphate = (2Z,6Z)-farnesyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68191", "l": "dodecanoyl-CoA + phytol <=> CoA + dodecanoate phytyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3318415", "l": "ATF2 acetylates histone H2B, H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5140741", "l": "WNT5A binds FZD and ROR receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21256", "l": "3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate", "d": []}, {"i": "EC:2.5.1.19", "l": "\"3-phosphoshikimate 1-carboxyvinyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54917", "l": "9-cis-retinol + NADP(+) => 9-cis-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964498", "l": "DREAM complex binds the CDC6 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140842", "l": "n fibrin monomers -> fibrin multimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140863", "l": "histone H2AK127 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-127 residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9726621", "l": "PGR binds PGR antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39700", "l": "(R)-3-hydroxy-(13Z)-eicosenoyl-CoA => (2E,13Z)-eicosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55418", "l": "biochanin A 7-O-beta-D-glucoside + H(+) + UDP => biochanin A + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49751", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate <=> CO2 + 2 H2O + NADP(+) + proviolacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37349", "l": "ADP + D-alanyl-(R)-lactate + phosphate => (R)-lactate + ATP + D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209536", "l": "IkB is ubiquitinated and degraded (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67728", "l": "DNA(n) + dZTP = diphosphate + DNA(n)-Z", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12402", "l": "NH4(+) + nicotinate beta-D-ribonucleotide => beta-nicotinamide D-ribonucleotide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20806", "l": "H(+) + hydrogencarbonate + NADH + propanoyl-CoA => 2-methyl-3-oxopropanoate + CoA + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694476", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33103", "l": "(2E,6E)-farnesyl diphosphate = alpha-muurolene + diphosphate", "d": []}, {"i": "EC:4.2.3.125", "l": "\"alpha-muurolene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15263", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22937", "l": "H2O + N-acetyl-D-glucosamine 6-phosphate => acetate + D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944236", "l": "Association of procollagen type XIV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23108", "l": "D-arabinono-1,4-lactone + H2O = D-arabinonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24752", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite = 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.7.12", "l": "\"red chlorophyll catabolite reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10572", "l": "vinylacetyl-CoA = (2E)-butenoyl-CoA", "d": []}, {"i": "EC:5.3.3.3", "l": "\"vinylacetyl-CoA Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33074", "l": "D-glucose 6-phosphate <=> 2-deoxy-L-scyllo-inosose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62108", "l": "an acyl-CoA + sn-glycero-3-phosphoethanolamine = a monoacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67162", "l": "6'-chloromelleolide F + FAD + H(+) + 2 H2O => chloride + FADH2 + melleolide F + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678418", "l": "Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5228992", "l": "ROCK1,ROCK2 are activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986258", "l": "SLIT2:ROBO1 binds CXCR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53404", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59970", "l": "CoA + O-octanoyl-L-threonyl-[protein] => L-threonyl-[protein] + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41333", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37134", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51550", "l": "(R)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine => (R)-tetrahydropapaverine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38684", "l": "ATP + H2O + sphing-4-enine(in) => ADP + H(+) + phosphate + sphing-4-enine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42078", "l": "2-hydroxyglutaryl-CoA + acetate => 2-hydroxyglutarate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948066", "l": "K63polyUb-IRAK1 dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62567", "l": "(4S)-limonene + A + H2O <=> (4S)-perillyl alcohol + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57458", "l": "4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP => (E)-sinapate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46521", "l": "an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42308", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18186", "l": "adenosine + O2 => 5'-dehydroadenosine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029468", "l": "Conversion of PA into DAG by PAP-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57408", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) = 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592316", "l": "Initial activation of proMMP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730835", "l": "Autophosphorylation of PKC-theta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58942", "l": "all-trans-lycopaoctaene + diphosphate + NAD(+) => (1R,2R,3R)-prephytoene diphosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.-", "l": "\"With NADH or NADPH as one donor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21887", "l": "H2O + trithionate <=> H(+) + sulfate + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48695", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52371", "l": "3'-phosphoadenylyl sulfate + cholesterol <=> adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112271", "l": "The receptor:G-protein complex dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35388", "l": "precorrin-7 + S-adenosyl-L-methionine => 2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392834", "l": "Activation of EPACs by cAMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68954", "l": "Mcm2-7 is phosphorylated by DDK (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-481007", "l": "Exocytosis of platelet alpha granule contents (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55548", "l": "N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12197", "l": "keto-D-fructose 6-phosphate + phosphate => acetyl phosphate + D-erythrose 4-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65097", "l": "a 2-acylglycerol + hexadecanoyl-CoA => a 1-hexadecanoyl-2-acylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30356", "l": "a quinol + methane + O2 => a quinone + H2O + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39629", "l": "(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42685", "l": "gamma-L-glutamyl-hercynylcysteine S-oxide + H2O => L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68317", "l": "1D-myo-inositol 2,3,4,5-tetrakisphosphate + H2O => 1D-myo-inositol 2,4,5-triphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102694", "l": "kinetin UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + kinetin <=> H+ + 9-(alpha-D-glucosyl)kinetin + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399930", "l": "Activation of PAK by Rac1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350769", "l": "trans-Golgi Network Coat Activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.39", "l": "\"adenain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.48", "l": "\"histone acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450488", "l": "BRF1 Complex recruits RNA degradation activities (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62601", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19932", "l": "[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64692", "l": "isobutanol + NAD(+) = 2-methylpropanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61847", "l": "solasodine + UDP-alpha-D-glucose <=> H(+) + solasodine 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28269", "l": "(2E,6E)-farnesyl diphosphate <=> (S)-beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28047", "l": "phosphate + propanoyl-CoA => CoA + propanoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55888", "l": "[aequorin]--dioxetanone = [excited state blue fluorescent protein] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.121", "l": "\"colneleate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001784", "l": "phosphotyrosine residue binding", "d": ["Binding to a phosphorylated tyrosine residue within a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70431", "l": "2 H(+)(out) + Li(+)(in) = 2 H(+)(in) + Li(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42795", "l": "cholesterol + hexadecanoyl-CoA <=> cholesteryl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40965", "l": "2 2-aminophenoxazin-3-one + 6 H2O => 4 2-aminophenol + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199576", "l": "KIR3DL2 interacting with HLA-A3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65416", "l": "dGMP(in) + NAD(+)(out) = dGMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58631", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV <=> FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48155", "l": "ganglioside GD1b(d18:1(4E)/18:0) + H2O <=> ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21186", "l": "a dolichyl beta-D-mannosyl phosphate + GDP => a dolichyl phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62296", "l": "(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) = (+)-malbrancheamide + 2 FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47843", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine <=> (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25047", "l": "(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46855", "l": "5alpha-cholest-8-en-3-one + H(+) + NADPH <=> 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15906", "l": "3-hydroxycyclohexanone + A => AH2 + cyclohexane-1,3-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35777", "l": "2-oxoglutaramate + UDP-alpha-D-kanosamine => L-glutamine + UDP-3-oxo-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712085", "l": "ALK mutants phosphorylate STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65322", "l": "chrodrimanin A + CO2 + succinate => 2-oxoglutarate + chrodrimanin E + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40126", "l": "an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40885", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2 => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1467466", "l": "ABCA4 mediates atRAL transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0031420", "l": "alkali metal ion binding", "d": ["Binding to an alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638845", "l": "CERK phosphorylates CERA to form C1P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61908", "l": "2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol = 2 AMP + asperphenamate + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928640", "l": "PAKs phosphorylate MLC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696457", "l": "BDH2 dehydrogenates 3HBA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32754", "l": "choline(out) <=> choline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693125", "l": "RHOF binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29849", "l": "(3Z)-tetradecenoyl-CoA => (2E)-tetradecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050241", "l": "pyrroline-2-carboxylate reductase activity", "d": ["Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35891", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75135", "l": "NADP(+) + neopine = H(+) + NADPH + neopinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22944", "l": "3beta-hydroxy-5beta-pregnane-20-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.277", "l": "\"3beta-hydroxy-5beta-steroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857686", "l": "FITM1, FITM2 bind TAGs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57836", "l": "H2O + O2 + thermospermine = 3-aminopropanal + H2O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29786", "l": "ATP + H2O + L-cysteine(in) <=> ADP + H(+) + L-cysteine(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0016929", "l": "deSUMOylase activity", "d": ["An thiol-dependent isopeptidase activity that cleaves SUMO from a target protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27716", "l": "guanosine + phosphate => GMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018785", "l": "RHOBTB2 binds GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684006", "l": "KPNA2 translocates NBN to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41415", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65930", "l": "3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine => 3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55020", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29391", "l": "GTP + H2O = diphosphate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.37", "l": "\"pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109813", "l": "GRB2-1 binds SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863718", "l": "AGFG1 binds VAMP7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58727", "l": "adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71405", "l": "2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2alpha-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9675026", "l": "Formation of the MLL1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450063", "l": "Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15411", "l": "1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44338", "l": "ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate => an L-alpha-amino acid + ATP + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373075", "l": "Metabotropic glutamate receptors bind glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47916", "l": "ATP + N-hexanoyl-(4R)-hydroxysphinganine = ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12189", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) => (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14752", "l": "1-hydroxy-2-naphthoate + O2 <=> (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56630", "l": "chloride + 2 H(+) + maleylacetate => 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770129", "l": "Formation of the Spliceosomal A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59619", "l": "beta-alanyl-L-arginine + H2O <=> beta-alanine + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9676264", "l": "Formation of the SET1B complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005026", "l": "transforming growth factor beta receptor activity, type II", "d": ["Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor."]}, {"i": "REACT:R-HSA-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34672", "l": "3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine => 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64887", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657786", "l": "NR1H2,3 binds the APOD gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1236970", "l": "Proteasomal clevage of exogenous antigen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73569", "l": "ITP(in) + UTP(out) => ITP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19404", "l": "methanol + NAD(+) <=> formaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18224", "l": "1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O <=> a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25816", "l": "H2O + norspermine + O2 = 3-aminopropanal + H2O2 + norspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75447", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46666", "l": "5beta-dihydrocorticosterone + NADP(+) => corticosterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18884", "l": "ATP + histamine + L-glutamate <=> ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69786", "l": "(2-aminophenyl)succinate + succinyl-CoA <=> 2-(2-aminophenyl)succinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56829", "l": "2,3,6-trichlorohydroquinone + chloride + glutathione disulfide => 2,3,5,6-tetrachlorohydroquinone + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10060", "l": "acetyl-CoA + D-tryptophan = CoA + H(+) + N-acetyl-D-tryptophan", "d": []}, {"i": "EC:2.3.1.34", "l": "\"D-tryptophan N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10416", "l": "fumarate + toluene = 2-benzylsuccinate", "d": []}, {"i": "EC:4.1.99.11", "l": "\"benzylsuccinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-418456", "l": "cGMP is degraded by PDEs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607753", "l": "CARD9 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702618", "l": "quizartinib-resistant FLT3 mutants don't bind quizartinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102544", "l": "ornaline synthase activity", "d": ["Catalysis of the reaction: L-ornithinium(1+) + 2-oxoglutarate + NADPH + H+ <=> ornaline + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22757", "l": "a long-chain primary fatty alcohol + O2 => a long-chain fatty aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-438026", "l": "Activation and dimerization of c-JUN in the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964492", "l": "DREAM complex binds the RBL1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9654533", "l": "KRAS4B recycles to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43994", "l": "16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+) => (2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156678", "l": "Activation of Cdc25C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73182", "l": "S-adenosyl-L-methionine + scutellarein <=> H(+) + S-adenosyl-L-homocysteine + scutellarein 4'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296045", "l": "Activation of Potassium transport channels (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50366", "l": "(S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389354", "l": "Activation of Vav1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62015", "l": "cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38862", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose <=> bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64719", "l": "NADP(+) + propanal <=> acrolein + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6794346", "l": "NRXNs bind NLGNs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68432", "l": "lutein + O2 = (3R)-hydroxy-beta-ionone + (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170149", "l": "Translocation of active Cdc25C to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66159", "l": "butanoyl-CoA + tyramine <=> CoA + H(+) + N-butanoyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11998", "l": "biphenyl-2,3-diol + H2O + NAD(+) => biphenyl-2-ol + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17157", "l": "ATP + creatine = ADP + H(+) + N-phosphocreatine", "d": []}, {"i": "EC:2.7.3.2", "l": "\"creatine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38816", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803388", "l": "TP53 stimulates CDKN1A (p21) transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373745", "l": "SDK1 homophillic interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39320", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849094", "l": "ARHGAP35 binds RASA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028273", "l": "PGH3 spontaneously dehydrates to PGJ3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11193", "l": "an (S)-2-haloacid + H2O => a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351849", "l": "Caspase-mediated cleavage of Etk (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51081", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49836", "l": "(5E)-tetradecenoyl-CoA + (R)-carnitine = (5E)-tetradecenoyl-(R)-carnitine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43140", "l": "guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.216", "l": "\"tRNA (guanine(26)-N(2))-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.34", "l": "\"6,7-dihydropteridine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4837364", "l": "Secretion of SOD3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24240", "l": "A + AMP + 2 H(+) + sulfite = adenosine 5'-phosphosulfate + AH2", "d": []}, {"i": "EC:1.8.99.2", "l": "\"adenylyl-sulfate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035888", "l": "isoguanine deaminase activity", "d": ["Catalysis of the reaction: isoguanine + H2O = xanthine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139920", "l": "Translocation of tBID to mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69271", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate <=> an alkenyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16388", "l": "4-hydroxybenzoate + 2 H(+) + NADPH + O2 <=> CO2 + H2O + hydroquinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45204", "l": "Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol = H2O + methyl-Co(III)-[methanol-specific corrinoid protein]", "d": []}, {"i": "EC:2.1.1.90", "l": "\"methanol--corrinoid protein Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70605", "l": "4-ethylphenol + NAD(+) => 4-hydroxystyrene + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730872", "l": "Activation of Calcineurin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65077", "l": "dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53382", "l": "H(+) + NADH + uridine(16) in tRNA => 5,6-dihydrouridine(16) in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41805", "l": "3-oxobutanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxybutanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203977", "l": "SAR1 Activation And Membrane Binding (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14158", "l": "H2O + triphosphate => diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710263", "l": "GZMB cleaves GSDME (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37032", "l": "D-ribonate => 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38989", "l": "(2E)-nonenoyl-CoA + H2O2 => nonanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374662", "l": "Translocation of Ezrin to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944233", "l": "Association of procollagen type XIX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865454", "l": "CBFB binds RUNX3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48281", "l": "ganglioside GM2 + UDP-alpha-D-galactose => ganglioside GM1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050560", "l": "aspartate-tRNA(Asn) ligase activity", "d": ["Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + diphosphate + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177937", "l": "Phosphorylation of EGFR by SRC kinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798749", "l": "Exocytosis of specific granule lumen proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48936", "l": "2-oxoglutarate + L-prolyl-[Skp1 protein] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41816", "l": "ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GD2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46710", "l": "AMP + H(+) + salicyl-[non-ribosomal peptide synthase] => 2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61221", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635868", "l": "ub-GLI is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0008079", "l": "translation termination factor activity", "d": ["Functions in the termination of translation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55054", "l": "CoA + H(+) + pentanoate => H2O + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36989", "l": "alpha-D-ribose 1,5-bisphosphate + cytosine => CMP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58446", "l": "H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33140", "l": "L-alanine(out) + L-aspartate(in) => L-alanine(in) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22258", "l": "a 3-oxoacyl-CoA + H(+) + NADPH => a (3R)-3-hydroxyacyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3814820", "l": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41047", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30528", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate => ADP + ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210694", "l": "Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3772430", "l": "CTNNBIP1 binds beta-catenin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56051", "l": "daidzein + UDP-alpha-D-glucose <=> daidzein 7-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24963", "l": "apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2 <=> [excited state blue fluorescent protein] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034890", "l": "endosulfan diol hydrolyase (cyclizing) activity", "d": ["Catalysis of the reaction: endosulfan diol = endosulfan ether + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164834", "l": "Enzyme-bound ATP is released (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22256", "l": "a (3R)-3-hydroxyacyl-CoA + NADP(+) = a 3-oxoacyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62074", "l": "6-phospho-D-galactono-1,5-lactone + H(+) + NADPH => D-galactose 6-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062072", "l": "H3K9me3 modified histone binding", "d": ["Binding to a histone H3 in which the lysine residue at position 9 has been modified by trimethylation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9639286", "l": "RRAGC,D exchanges GTP for GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73577", "l": "CAD hexamer transforms L-Gln to CAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11581", "l": "a CDP-1,2-diacyl-sn-glycerol + myo-inositol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30367", "l": "adenosylcob(III)alamin 5'-phosphate + H2O = adenosylcob(III)alamin + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592362", "l": "Activation of proMMP7 by MMP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254291", "l": "ERBB4s80 binds STAT5A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42850", "l": "8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+) => 8-demethyltetracenomycin C + dTDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.240751554780076", "identifiers": [{"i": "GO:0003777", "l": "microtubule motor activity", "d": ["A motor activity that generates movement along a microtubule, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56552", "l": "ATP + L-threonyl-[rhodopsin] = ADP + H(+) + O-phospho-L-threonyl-[rhodopsin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49883", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035197", "l": "siRNA binding", "d": ["Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035950", "l": "Defective B4GALT1 does not transfer Gal to a branch of keratan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266350", "l": "CETP-mediated lipid exchange: LDL gains cholesterol ester (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40144", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O => (9Z,12Z)-octadecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31223", "l": "cis-beta-D-glucosyl-2-hydroxycinnamate + H2O = beta-D-glucose + cis-2-coumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0004351", "l": "glutamate decarboxylase activity", "d": ["Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.38", "l": "\"malate dehydrogenase (oxaloacetate-decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32895", "l": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.56", "l": "\"1,8-cineole 2-exo-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735143", "l": "NKX2-5 binds the GATA4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804998", "l": "p14ARF forms a ternary complex with MDM2 and TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70994", "l": "H(+)(in) + L-mannopyranose(in) <=> H(+)(out) + L-mannopyranose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57845", "l": "fraxetin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44648", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55352", "l": "all-trans-retinol = 13-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30705", "l": "CO2 + phenol => H(+) + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20167", "l": "an alcohol + H(+) + N(5)-acyl-L-ornithine => H2O + N(5)-acyl-L-ornithine ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72477", "l": "cis-aconitate(out) + citrate(in) => cis-aconitate(in) + citrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71832", "l": "chloride(out) + creatine(out) + 2 Na(+)(out) => chloride(in) + creatine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097110", "l": "scaffold protein binding", "d": ["Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53001", "l": "17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate => 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392295", "l": "Gbeta:gamma recruits PI3K gamma (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44276", "l": "eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34743", "l": "15-methylhexadecasphinganine 1-phosphate = 13-methyltetradecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63697", "l": "SN-38 + UDP-alpha-D-glucuronate => H(+) + SN-38 O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32032", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + gamma-curcumene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22951", "l": "D-tagatofuranose 1,6-bisphosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71337", "l": "chloride(in) + L-tryptophan(in) + 2 Na(+)(in) => chloride(out) + L-tryptophan(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420724", "l": "CASR binds Ca2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29615", "l": "alpha-maltotriose + beta-maltose = alpha-maltotetraose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641205", "l": "RSPO:LGR binds ZNRF3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.52", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56881", "l": "a 3beta-hydroxy-Delta(5)-steroid + NADP(+) => a 3-oxo-Delta(5)-steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40698", "l": "1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol <=> 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65547", "l": "ganglioside GM1 + H2O <=> an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66796", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41973", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) => CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202717", "l": "Heterodimerization of CEACAMs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9639286", "l": "RRAGC,D exchanges GTP for GDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0048039", "l": "ubiquinone binding", "d": ["Binding to ubiquinone, a quinone derivative with a tail of isoprene units."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69880", "l": "6alpha-hydroxycastasterone + O2 + reduced [NADPH--hemoprotein reductase] => castasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67135", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH <=> (1S,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13893", "l": "H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate = ADP + AMP + 2 H(+)", "d": []}, {"i": "EC:3.6.1.29", "l": "\"bis(5'-adenosyl)-triphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805061", "l": "CK2 binds FACT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55938", "l": "all-trans-4-hydroxyretinal + H(+) + NADH => all-trans-4-hydroxyretinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56356", "l": "3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 = 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68119", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol <=> a triacylglycerol + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25347", "l": "D-tyrosyl-tRNA(Tyr) + H2O = D-tyrosine + tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352268", "l": "Cleavage of Satb1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448673", "l": "Formation of caspase-1 p10/p20 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684275", "l": "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72671", "l": "eIF5B:GTP is hydrolyzed and released (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53062", "l": "estrone 4-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxyestrone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61946", "l": "24-methylene cholesteryl beta-D-glucoside + H(+) + UDP => 24-methylenecholesterol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865107", "l": "MICAL1 produces NADP+, H2O2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43878", "l": "3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate => 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36429", "l": "diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine => 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72663", "l": "De novo formation of eIF2:GTP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70191", "l": "ATP + NAD(+) = 3'-NADP(+) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34143", "l": "cannabinerolate + O2 = Delta(9)-tetrahydrocannabinolate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40333", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5671702", "l": "AP1G2 binds HGS and CHMP2A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32827", "l": "ATP + H2O + methionine(out) = ADP + H(+) + methionine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59585", "l": "ATP + beta-alanine + L-lysine => ADP + beta-alanyl-L-lysine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27581", "l": "(R)-N-tert-butylpiperazine-2-carboxamide + H2O <=> (R)-piperazine-2-carboxylate + tert-butylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75606", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> plasmodiophorol A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65775", "l": "2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68646", "l": "alpha-thujene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390438", "l": "FAR2 reduces PalmCoA to HXOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19322", "l": "N,N-dimethylaniline N-oxide => formaldehyde + N-methylaniline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63710", "l": "a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62022", "l": "D-glucose + sitosterol => H2O + sitosteryl 3-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.2", "l": "\"diacylglycerol cholinephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791109", "l": "GADD45A binds PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5323526", "l": "FRAT proteins bind GSK3beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57112", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354097", "l": "Activation of Talin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-593685", "l": "Netrin-4 binds DCC/UNC5A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10959", "l": "(E)-cinnamate + H(+) + NADPH + O2 <=> H2O + NADP(+) + trans-2-coumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2995388", "l": "PP2A dephosphorylates BANF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73201", "l": "maleate(out) + sulfate(in) => maleate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615682", "l": "Complexed PIWIL1 binds pre-piRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.435", "l": "\"L-fucose dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114558", "l": "Thrombin-activated PARs activate Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24371", "l": "L-ornithine <=> L-proline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18095", "l": "H(+) + NADPH + uracil => 5,6-dihydrouracil + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14199", "l": "ADP + H(+) + L-asparagine + phosphate => ATP + L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35212", "l": "dIDP + H2O => dIMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72645", "l": "1,6-dimethoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine => 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944220", "l": "Association of procollagen type XXIII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936655", "l": "sulfite results from reduction of APS (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35866", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507868", "l": "Aquaporins passively transport water into cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934465", "l": "SHC1 binds PTPN12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56438", "l": "2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11777", "l": "2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] => (9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674093", "l": "PDGFRs bind type I TKI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34267", "l": "acetyl-CoA + fumigaclavine B = CoA + fumigaclavine A", "d": []}, {"i": "EC:2.3.1.205", "l": "\"fumigaclavine B O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13975", "l": "2 H(+)(out) + 2 phosphate => diphosphate + H(+)(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9629679", "l": "PDE3A inhibitors bind PDE3A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299297", "l": "Activation of THIK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25900", "l": "D-arabino-hex-3-ulose 6-phosphate = beta-D-fructose 6-phosphate", "d": []}, {"i": "EC:5.3.1.27", "l": "\"6-phospho-3-hexuloisomerase\"", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64994", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine => acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-421831", "l": "trans-Golgi Network Coat Assembly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65761", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a 17alpha-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54041", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (3E,7E)-dolathalia-3,7,11-triene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63375", "l": "an acyl-CoA + L-cysteinyl-[protein] <=> an S-acyl-L-cysteinyl-[protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26274", "l": "Co-precorrin-3 + S-adenosyl-L-methionine => Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53216", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50750", "l": "naphthalene-1,2,4,8-tetrol => H2O + juglone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40313", "l": "(2E)-hexenoyl-CoA + H2O2 => hexanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626060", "l": "HSPA8:Substrate dissociates from LAMP2a multimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62420", "l": "a (R)-2-hydroxy fatty acid + O2 = a fatty acid + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990254", "l": "keratin filament binding", "d": ["Binding to a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49990", "l": "H2O + methyl acetate + NADP(+) => acetone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675473", "l": "SH2B binds JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44783", "l": "2-demethylmenaquinol-9 + S-adenosyl-L-methionine <=> H(+) + menaquinol-9 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69644", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 => (2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380780", "l": "Activation of Src (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984733", "l": "Kinesin-3 is a dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679266", "l": "Beclin-1 complex translocates to the ER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306876", "l": "NLRP3 activation by small molecules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685606", "l": "CLEC2D binds KLRB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53357", "l": "5,6-dihydrouridine(20b) in tRNA + NADP(+) => H(+) + NADPH + uridine(20b) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38104", "l": "L-galactonate => 2-dehydro-3-deoxy-L-galactonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218847", "l": "PAK2 binds NCK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55625", "l": "an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + H2O => 3-methylcytosine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2423785", "l": "CR:atREs binds apoE and HSPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70510", "l": "LDH tetramer oxidises LACT to PYR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13921", "l": "ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29706", "l": "L-valine(in) <=> L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.3", "l": "\"monoterpenyl-diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683888", "l": "LMCD1 binds GATA6, sequestering it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928614", "l": "EFNB:GRB4 binds GIT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828024", "l": "SOX17 and TFAP2C bind the NANOG gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68075", "l": "Delta(2)-thiazoline-2-carboxylate + 2 H(+) + NADPH <=> L-thiazolidine-2-carboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66163", "l": "hexanoyl-CoA + tyramine <=> CoA + H(+) + N-hexanoyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66309", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose => an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193695", "l": "IRAK interacts with TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19079", "l": "3-deoxyglucosone + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446634", "l": "IRAK4 is activated by autophosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102458", "l": "cyanidin 3-O-glucoside 5-O glucosyltransferase (vanilloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose <=> cyanin betaine + vanillate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9635428", "l": "FadD26, FadD28 transfer LCFA adenylate ester to Pks5 (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668404", "l": "TNFA binds TNFR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374663", "l": "DCC interaction with Ezrin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50272", "l": "(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O = resolvin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10402", "l": "2-oxoglutaramate + L-alanine => L-glutamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17377", "l": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67849", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ATP + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19250", "l": "glyoxylate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65510", "l": "H2O2 + NH4(+) + pre-mycofactocin => 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28917", "l": "4-aminobutanoate(out) + H(+)(out) => 4-aminobutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17779", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+) => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65154", "l": "(2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP => (2S)-naringenin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9818574", "l": "TASP1 cleaves KMT2A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74939", "l": "2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + O2 = a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2173781", "l": "MARCO (SCARA2) binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807872", "l": "Active ARF recruits coatomer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66938", "l": "avenanthramide C + CoA => (E)-caffeoyl-CoA + 5-hydroxyanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1861789", "l": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61236", "l": "H2O + L-methionine + O2 = 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28662", "l": "beta-lactose + H2O <=> beta-D-galactose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.21", "l": "\"Enterobacter ribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73876", "l": "(R)-adrenaline(out) => (R)-adrenaline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173115", "l": "Formation of Pre-Integration Complex (PIC) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22612", "l": "(3S)-citramalyl-CoA = acetyl-CoA + pyruvate", "d": []}, {"i": "EC:4.1.3.25", "l": "\"(S)-citramalyl-CoA lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5333671", "l": "CLCAs self cleave (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55063", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22052", "l": "A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine", "d": []}, {"i": "EC:1.7.99.1", "l": "\"hydroxylamine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56385", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 => (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30629", "l": "(2S)-2-acetolactate + H(+) + NADH => (2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202726", "l": "F11R dimerises (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68239", "l": "L-glutamine(in) + Na(+)(in) <=> L-glutamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64768", "l": "S-3-(hexan-1-ol)-L-cysteine = 2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169398", "l": "ISGylation of host protein filamin B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141423", "l": "Binding of the MCC complex to the APC/C complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098615", "l": "dimethyl selenide methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + dimethyl selenide => S-adenosyl-L-homocysteine + trimethylselenonium."]}, {"i": "REACT:R-HSA-2408554", "l": "Me2Se is methylated to Me3Se+ by INMT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696268", "l": "RND3 binds effectors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52943", "l": "chenodeoxycholate + UDP-alpha-D-glucuronate <=> chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53003", "l": "17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate <=> 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42406", "l": "beta-D-glucose + D-galactose 6-phosphate => H2O + lactose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186765", "l": "PLC-gamma binds to the active receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803890", "l": "SFN dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202722", "l": "CD48 binds CD244 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65790", "l": "3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57296", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75182", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (R)-axinyssene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251555", "l": "Expression of AXIN1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15005", "l": "2-oxoglutarate + gibberellin A1 + O2 = CO2 + gibberellin A8 + succinate", "d": []}, {"i": "EC:1.14.11.13", "l": "\"gibberellin 2beta-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211983", "l": "CYP2J2 oxidises ARA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64911", "l": "CTP + 2 H2O <=> CMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849900", "l": "SALMs1-3 bind each other in cis interactions (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29945", "l": "2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out) => 2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15924", "l": "2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol <=> a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53640", "l": "(2E,6E)-farnesyl diphosphate = (-)-alpha-amorphene + diphosphate", "d": []}, {"i": "EC:4.2.3.162", "l": "\"(-)-alpha-amorphene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990053", "l": "DNA-5-methylcytosine glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 5-methylcytosine + H2O = DNA with abasic site + 5-methylcytosine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the DNA 5-methylcytosine and the deoxyribose sugar to remove the 5-methylcytosine, leaving an abasic site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14726", "l": "2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909718", "l": "Formation of p-STAT1 homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72672", "l": "The 60S subunit joins the translation initiation complex  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866851", "l": "CFTR transits to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52785", "l": "2-sulfenohercynine + AH2 + H(+) => A + ergothioneine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11253", "l": "H(+) + hydroxylamine + L-asparagine => beta-L-aspartylhydroxamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190245", "l": "FGFR1b binds to FGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373747", "l": "Phosphorylation of nephrin by FYN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047665", "l": "aminolevulinate transaminase activity", "d": ["Catalysis of the reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29376", "l": "AMP + H2O => adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14903", "l": "casbene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33290", "l": "A + spermidine <=> 1-pyrroline + AH2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799097", "l": "ATM phosphorylates ZNF420 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948775", "l": "MKRN1 polyubiquitinates PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74983", "l": "(3R)-3-isocyanylbutanoyl-AMP + holo-[ACP] = (3R)-3-isocyanylbutanoyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016972", "l": "thiol oxidase activity", "d": ["Catalysis of the reaction: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + 2 H2O2."]}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004571", "l": "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209823", "l": "Tyrosine is hydroxylated to dopa (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45248", "l": "butanoate(out) = butanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47333", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635845", "l": "GLI proteins bind CDC73 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62252", "l": "2 hydrogencarbonate(out) + Zn(2+)(out) = 2 hydrogencarbonate(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205306", "l": "Interaction of SHP1 and KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210687", "l": "STAT92E transports from the nucleus to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52895", "l": "H2O + NADP(+) + nitrosobenzene <=> H(+) + NADPH + nitrobenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649733", "l": "mature p21 RAS binds GDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41056", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26061", "l": "methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+) => Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39109", "l": "(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74925", "l": "a (2E)-enoyl-[ACP] + glycine + H2O => a (3R)-3-[(carboxymethyl)amino]fatty acid + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18245", "l": "3'-dephospho-CoA + ATP = ADP + CoA + H(+)", "d": []}, {"i": "EC:2.7.1.24", "l": "\"dephospho-CoA kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034348", "l": "type III interferon receptor activity", "d": ["Combining with a type III interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Interferon lambda is the only member of the type III interferon found so far."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44999", "l": "(R)-carnitine + acetoacetyl-CoA <=> CoA + O-3-oxobutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21587", "l": "NAD(+) + propane-1,2-diol 1-phosphate <=> H(+) + hydroxyacetone phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856951", "l": "PP2A demethylation by PPME1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050337", "l": "thiosulfate-thiol sulfurtransferase activity", "d": ["Catalysis of the reaction: thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66998", "l": "2-methylpentanoyl-CoA + AMP + diphosphate => 2-methylpentanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17277", "l": "6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O", "d": []}, {"i": "EC:4.2.1.12", "l": "\"phosphogluconate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11108", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)", "d": []}, {"i": "EC:2.8.2.17", "l": "\"chondroitin 6-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15771", "l": "adenosylcob(III)inamide phosphate + ADP + H(+) => adenosylcob(III)inamide + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799332", "l": "ATR phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693593", "l": "D-loop extension by DNA polymerases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050185", "l": "phosphatidylinositol deacylase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + H2O = 1-acyl-sn-glycero-3-phospho-D-myo-inositol + a carboxylate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21798", "l": "dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH => dTDP-beta-L-rhamnose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673322", "l": "p-T,Y-MAPK8 translocates from the cytosol to the nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68583", "l": "ATP + H2O + L-kynurenine(out) <=> ADP + H(+) + L-kynurenine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.100", "l": "\"mannan 1,4-mannobiosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21027", "l": "CoA + glyoxylate + NADP(+) <=> H(+) + NADPH + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68337", "l": "(R)-4'-phosphopantetheine sulfonate + H2O => (R)-pantetheine sulfonate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42583", "l": "ATP + L-serine + tRNA(Sec) <=> AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48437", "l": "H2O + pentanoate ester => an aliphatic alcohol + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198508", "l": "MDH1 oxidizes MAL to OA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374909", "l": "Metabolism of Noradrenaline (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052811", "l": "1-phosphatidylinositol-3-phosphate 4-kinase activity", "d": ["Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15939", "l": "an aldehyde + H(+) + NADPH => a primary alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34516", "l": "tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine => N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74864", "l": "(R)-salsolinol + S-adenosyl-L-methionine => H(+) + N-methyl-(R)-salsolinol + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29555", "l": "H2O + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45870", "l": "4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA => 9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44424", "l": "a fatty acyl-CoA + heptadecasphing-4-enine = CoA + H(+) + N-acyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41467", "l": "ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.77", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47744", "l": "demethylphylloquinone + H(+) + NADPH = demethylphylloquinol + NADP(+)", "d": []}, {"i": "EC:1.6.5.12", "l": "\"demethylphylloquinone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62003", "l": "3 A + protoporphyrinogen IX <=> 3 AH2 + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42557", "l": "uridine(2819) in 21S rRNA => pseudouridine(2819) in 21S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201634", "l": "Caspase-mediated cleavage of FADK 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36950", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26457", "l": "NADP(+) + propanoyl-CoA <=> acryloyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0004340", "l": "glucokinase activity", "d": ["Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69009", "l": "2 H(+) + L-aspartate + 3 NADPH + 3 O2 => 2-nitrobutanedioate + 4 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51018", "l": "6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate => 7,8-dihydroneopterin 3'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69130", "l": "4-methyl-2-oxopentanoate + glycine => glyoxylate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32412", "l": "(1R,2R,4S)-isodihydrocarveol + NAD(+) => (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42560", "l": "uridine(27/28) in mitochondrial tRNA = pseudouridine(27/28) in mitochondrial tRNA", "d": []}, {"i": "EC:5.4.99.44", "l": "\"mitochondrial tRNA pseudouridine(27/28) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9648268", "l": "HTR1A binds HTR1A antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42011", "l": "5alpha-pregnan-20beta-ol-3-one + NAD(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-381109", "l": "IRE1 binds IRE1 forming dimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663246", "l": "RORA, EP300 bind NPAS2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55062", "l": "a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070855", "l": "myosin VI head/neck binding", "d": ["Binding to the head/neck region of a myosin VI heavy chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445072", "l": "Interaction of PAK1 with Rac1-GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446372", "l": "Association of  PARVA with TESK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29413", "l": "glycolate(out) + H(+)(out) => glycolate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19754", "l": "ATP + diphthine-[translation elongation factor 2] + NH4(+) => AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25732", "l": "H(+) + N,N-dihydroxy-L-tetrahomomethionine => (E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388817", "l": "ICOS binds ICOSL/B7-H2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21531", "l": "[phosphate](n) + H2O <=> [phosphate](n-1) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264622", "l": "Cho is acetylated to AcCho by CHAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44700", "l": "a 2,3-saturated acyl-CoA + FAD + H(+) = a (2E)-enoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851436", "l": "CFHR dimers bind C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23982", "l": "linear maltodextrin => cyclomaltodextrin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58700", "l": "FADH2-C4alpha-hydroperoxide + NADPH + rifampicin = FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783530", "l": "gp130:JAKs bind CNTFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-984606", "l": "Kinesin-5 is a homotetramer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72385", "l": "Na(+)(in) + urate(out) => Na(+)(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850961", "l": "PREX2 binds PTEN and inhibits it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210881", "l": "Dimerization of Tie2/Ang1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47022", "l": "[DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43299", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373087", "l": "Receptor CCR6 binds CCL20 ligand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0003976", "l": "UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682718", "l": "nsp15 forms a hexamer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23288", "l": "acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.2.1.10", "l": "\"acetaldehyde dehydrogenase (acetylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640862", "l": "Tankyrase binds AXIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905573", "l": "ganglioside GM1 binding", "d": ["Binding to ganglioside GM1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66257", "l": "ATP + H(+) + IC-asc-C7 => diphosphate + IC-asc-C7-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37601", "l": "(9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O => (9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69406", "l": "uracil(out) => uracil(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43648", "l": "H(+) + hexadecanoyl-CoA + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58077", "l": "1-(11Z-eicosenoyl)-glycerol + H2O => (11Z)-eicosenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22815", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) <=> 5,10-methenyltetrahydrofolate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031894", "l": "DPAn-3 maresins translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21604", "l": "styrene oxide = 2-phenylacetaldehyde", "d": []}, {"i": "EC:5.3.99.7", "l": "\"styrene-oxide isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19767", "l": "3-hydroxypropanal + H2O => glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36759", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine = alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.306", "l": "\"UDP-GalNAc:alpha-D-GalNAc-diphosphoundecaprenol alpha-1,3-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68603", "l": "ORC5 binds ORC2:ORC3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641205", "l": "RSPO:LGR binds ZNRF3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.254", "l": "\"N-terminal methionine N(alpha)-acetyltransferase NatB\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.13", "l": "\"acetate--CoA ligase (ADP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190263", "l": "FGFR3b binds to FGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62228", "l": "(E)-ascladiol + A = AH2 + patulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14371", "l": "glycolate + phosphate => 2-phosphoglycolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61689", "l": "ATP + holo-[peptidyl-carrier protein] + L-threonine => AMP + diphosphate + L-threonyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56526", "l": "AH2 + heme d1 => A + dihydro-heme d1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9817575", "l": "ERO1B oxidizes P4HB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13953", "l": "a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70771", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10030", "l": "2-oxoglutarate + H2O2 + NH4(+) => D-glutamate + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55110", "l": "(3R)-hydroxynonanoyl-[ACP] + NADP(+) => 3-oxononanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19399", "l": "CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => (R)-4'-phosphopantothenate + CTP + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37379", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58682", "l": "AH2 + FAD + H(+) => A + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61051", "l": "lochnericine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046099", "l": "Desaturation of tetracosapentaenoyl-CoA to tetracosahexaenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23207", "l": "chlorogenate + D-glucarate <=> 2-O-caffeoylglucarate + L-quinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009485", "l": "IL34:CSF1 binds CSF1R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052867", "l": "phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205238", "l": "SHP2 interacts with p-KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56553", "l": "ATP + L-threonyl-[rhodopsin] => ADP + H(+) + O-phospho-L-threonyl-[rhodopsin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27493", "l": "S-adenosyl-L-methionine + tricetin = 3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839031", "l": "Dimerization of cytosolic FGFR1 fusion proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227695", "l": "NLRC5 binds to CARD domain of Mda5 and prevents IPS1 binding. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63751", "l": "UDP-alpha-D-glucuronate + zolasartan <=> UDP + zolarsartan-2-N-beta-D-glucuronide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25214", "l": "H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56472", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990119", "l": "RNA helicase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of an RNA helicase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912724", "l": "CBL binds B-cell linker protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013147", "l": "RAC1 GDIs block activation of RAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062131", "l": "3-butenylglucosinolate 2-hydroxylase activity", "d": ["Catalysis of the reaction: gluconapin + a reduced electron acceptor + O2 = xi-progoitrin + an oxidized electron acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47997", "l": "1,6-dihydro-beta-NAD + H(+) + O2 => H2O2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9671145", "l": "DKC1 binds SHQ1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110219", "l": "Cleavage of thymine by TDG glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76416", "l": "Benzene is hydroxylated to phenol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863727", "l": "STON2 is neddylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873917", "l": "Translocation of STAT1 dimer to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63935", "l": "abscisate(in) + ATP + H2O <=> abscisate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043768", "l": "S-ribosylhomocysteine lyase activity", "d": ["Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39489", "l": "(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11983", "l": "2 gamma-L-glutamyl-L-cysteine + NADP(+) <=> bis-gamma-glutamylcystine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68828", "l": "borneol + NAD(+) = camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62562", "l": "(4R)-perillyl alcohol + AH2 => (4R)-limonene + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10138", "l": "2-hydroxy-3-oxopropanoate + CO2 => 2 glyoxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18094", "l": "5,6-dihydrouracil + NADP(+) => H(+) + NADPH + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-179410", "l": "Association of Nek2A with MCC:APC/C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24681", "l": "5,6,7,8-tetrahydromethanopterin + formaldehyde <=> 5,10-methylenetetrahydromethanopterin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-984689", "l": "Kinesin-7 is a dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016495", "l": "C-X3-C chemokine receptor activity", "d": ["Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50917", "l": "a carboxylate + ATP + H(+) + NADPH => AMP + an aldehyde + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65212", "l": "(2E)-dodecenoyl-CoA + H2O = (2E)-dodecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54112", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + selina-4(15),7(11)-diene", "d": []}, {"i": "EC:4.2.3.181", "l": "\"selina-4(15),7(11)-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65683", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851919", "l": "Activated MET binds GAB1 and GRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008933", "l": "lytic transglycosylase activity", "d": ["Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114683", "l": "Phosphorylation of Platelet Sec-1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671868", "l": "Phosphorylated LEPR Binds STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696323", "l": "CNRs bind CNR agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20432", "l": "apigenin + S-adenosyl-L-methionine <=> acacetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849882", "l": "SALMs 1-4 bind reticulon 3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33617", "l": "AMP + diphosphate + octadecanoyl-CoA => ATP + CoA + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1980125", "l": "ITCH binds DTX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675656", "l": "EDA:EDAR binds EDARADD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65286", "l": "3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Thr-[protein] + CMP + H(+) => 3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75224", "l": "H2O + L-fucono-1,4-lactone => H(+) + L-fuconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396007", "l": "IRF3 is phosphorylated by TBK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0045119", "l": "azole:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36784", "l": "L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2169046", "l": "Degradation of TGF-beta receptor complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40458", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA <=> (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606784", "l": "Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19463", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+) => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23676", "l": "ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": []}, {"i": "EC:6.3.2.13", "l": "\"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022141", "l": "Prolysyl oxidase activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37683", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46547", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434633", "l": "PIP2 binds inhibiting VAV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66465", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O => scalarane-17alpha-19-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47969", "l": "ganglioside GM2 + H2O => ganglioside GM3 + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296301", "l": "CCRL2 binds CCL19 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13923", "l": "gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29100", "l": "a menaquinone + 5 H(+)(in) + NADH => a menaquinol + 4 H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944261", "l": "Association of procollagen type XIII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374173", "l": "AGT(34-41) binds to AGTR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796691", "l": "SPATA2 links CYLD to LUBAC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37392", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954056", "l": "E2F6 binds TFDP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57771", "l": "2-nitrotoluene + NADH + O2 <=> 3-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.145", "l": "\"galactan 1,3-beta-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864577", "l": "TFAP2C translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60063", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46671", "l": "21-hydroxyprogesterone + H(+) + NADPH <=> 5beta-dihydrodeoxycorticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694409", "l": "Nucleotide exchange on RAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37099", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O = a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989772", "l": "Expression of GLIPR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22321", "l": "2 alpha-D-glucose 1-phosphate + H2O => D-maltose + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030783", "l": "[cytochrome c]-methionine S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17200", "l": "2 3-(4-hydroxyphenyl)pyruvate + O2 <=> 2 4-hydroxyphenylacetate + 2 CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42328", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.003741351937961", "identifiers": [{"i": "GO:0016814", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2."]}, {"i": "EC:3.5.4.-", "l": "\"In cyclic amidines\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17715", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine => (R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16335", "l": "diphosphate + holo-[citrate lyase ACP] => 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11002", "l": "a D-alpha-amino acid + CO2 + NH4(+) => an N-carbamoyl-D-amino acid + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.45", "l": "\"melamine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004735", "l": "pyrroline-5-carboxylate reductase activity", "d": ["Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74847", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + ATP = 3-diphospho-1D-myo-inositol 1,2,4,5-tetrakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45779", "l": "(indol-3-yl)acetonitrile + 2 H2O <=> (indol-3-yl)acetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61105", "l": "(2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190265", "l": "FGFR4 binds to FGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.4.-", "l": "\"With a disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851018", "l": "BTN2A1 binds DC-SIGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74249", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696815", "l": "ELAC2 cleaves the 3' end of pre-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174235", "l": "Association of Emi1 with Cdc20 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983158", "l": "Trimming of peptides in ER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430308", "l": "PARVB interacts with Alpha-actinin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177690", "l": "Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196417", "l": "Reduction of desmosterol to cholesterol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2314678", "l": "ASA- acetylates PTGS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18672", "l": "adenosine + H2O <=> adenine + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018575", "l": "chlorocatechol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 3,6-dichlorocatechol + O2 = 2 H+ + 2,5-dichloro-cis,cis-muconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8981926", "l": "RAC1 and CDC42 activate PAK3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27935", "l": "(3S)-3-hydroxy-D-aspartate => glycine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37936", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851436", "l": "CFHR dimers bind C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70117", "l": "6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69218", "l": "(omega-1)-methyl-3-oxo-fatty acyl-CoA + H(+) + NADPH => (omega-1)-methyl-(3R)-hydroxy-fatty acyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45152", "l": "3-hydroxy-3-(methylsulfanyl)propanoyl-CoA = 3-oxopropanoyl-CoA + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45588", "l": "a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.20", "l": "\"long-chain-fatty-acid--[acyl-carrier-protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390835", "l": "DRD1,5 bind DA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004847", "l": "urea carboxylase activity", "d": ["Catalysis of the reaction: ATP + bicarbonate + urea = ADP + 2 H+ + phosphate + urea-1-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46223", "l": "androst-5-en-3beta,17beta-diol + NAD(+) <=> 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41503", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653886", "l": "B4GALT1 binds LALBA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299487", "l": "Precursor proteins enter TIMM23 SORT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103077", "l": "quercetin 3-glucoside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-glucoside + UDP-L-rhamnose <=> quercetin-3-O-glucoside-7-O-rhamnoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902051", "l": "(25S)-Delta(4)-dafachronate binding", "d": ["Binding to (25S)-Delta(4)-dafachronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54492", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine = 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15115", "l": "5alpha-cholestane-3beta,5,6beta-triol => 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.250759876326711", "identifiers": [{"i": "GO:0140678", "l": "molecular function inhibitor activity", "d": ["A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59452", "l": "a long-chain primary fatty alcohol + NADP(+) = a long-chain fatty aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16325", "l": "1-phospho-alpha-D-glucuronate + H(+) + UTP = diphosphate + UDP-alpha-D-glucuronate", "d": []}, {"i": "EC:2.7.7.44", "l": "\"glucuronate-1-phosphate uridylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983147", "l": "Release of E3 from polyubiquitinated substrate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168445", "l": "PTP1B binds the GH receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28379", "l": "ATP + N(6)-(D-fructosyl)-L-lysine => ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54392", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65177", "l": "A + protoaustinoid A => AH2 + protoaustinoid B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52831", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 <=> (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24611", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) <=> 2,5-dioxopentanoate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23921", "l": "(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59273", "l": "L-cysteine => D-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35257", "l": "ADP + H(+) + lipid A-core(out) + phosphate => ATP + H2O + lipid A-core(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798743", "l": "Exocytosis of secretory granule membrane proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214891", "l": "Full-length GD is cleaved by an unknown protease (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53350", "l": "H(+) + NADH + uridine(20a) in tRNA => 5,6-dihydrouridine(20a) in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30946", "l": "FAD + H(+) + octanoyl-CoA <=> (2E)-octenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421222", "l": "inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30556", "l": "GTP + L-glutamate + oxidized coenzyme F420-0 => GDP + H(+) + oxidized coenzyme F420-1 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212432", "l": "Formation of DRIP coactivator complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70312", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629245", "l": "NEIL3 D132V does not cleave 5-guanidinohydantoin (Gh) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39846", "l": "1,3-diacyl-sn-glycerol + an acyl-CoA <=> a triacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466710", "l": "Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213201", "l": "Formation of collagen fibres (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56283", "l": "3'-L-prolyl-AMP + holo-[peptidyl-carrier protein] <=> AMP + L-prolyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10286", "l": "(3R)-beta-leucine => L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102520", "l": "L-threonine O-3-phosphate phosphatase activity", "d": ["Catalysis of the reaction: O-phospho-L-threonine + H2O = L-threonine + hydrogenphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39150", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60016", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + sesquisabinene B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56249", "l": "1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653514", "l": "USP17L2 deubiquitinates RCE1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380311", "l": "Recruitment of Plk1 to centrosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42921", "l": "S-adenosyl-L-methionine + uridine(1498) in 16S rRNA => H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64545", "l": "acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine => 8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30012", "l": "ATP + beta-D-galactose(out) + H2O => ADP + beta-D-galactose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036431", "l": "dCMP kinase activity", "d": ["Catalysis of the reaction: ATP + dCMP = ADP + dCDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12642", "l": "(2R)-3-phosphoglycerate + NAD(+) => 3-phosphooxypyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15291", "l": "[(1->4)-beta-D-xylan](n+1) + H(+) + UDP => [(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466718", "l": "NRPE dissociates to atRAL and PE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-996755", "l": "ZFPM proteins bind GATA proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2214324", "l": "Collagen type VII dimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005275", "l": "amine transmembrane transporter activity", "d": ["Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804402", "l": "TP53 binds POU4F1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51765", "l": "dimethylallyl diphosphate + phlorisovalerophenone => 4-prenylphlorisovalerophenone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72068", "l": "(2S)-2-aminobutanoate + ATP + L-glutamate => ADP + gamma-L-glutamyl-(2S)-2-aminobutanoate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9705584", "l": "HMGCR dimer binds statins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0043855", "l": "cyclic nucleotide-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34764", "l": "(S,S)-tartrate(out) + succinate(in) => (S,S)-tartrate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58756", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48555", "l": "1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> (9S,13S,15Z)-12-oxophyto-10-15-dienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210292", "l": "Interaction of DAP12 and TREM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733960", "l": "Bile salts and acids dissociate from ALB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73090", "l": "AMP(out) + FAD(in) <=> AMP(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8878654", "l": "ACP6 hydrolyses MYS-LPA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69268", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate = an alkenyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3204303", "l": "MRE11 binds cytosolic DNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24766", "l": "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate => UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33813", "l": "6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O => 3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179291", "l": "UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209096", "l": "E2F1, E2F2, or E2F3 and SP1 bind p14ARF promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44124", "l": "hexadecanoyl-CoA + tetradecan-1-ol = CoA + tetradecanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2562526", "l": "PLK1 phosphorylates OPTN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54153", "l": "a uridine in rRNA + S-adenosyl-L-methionine => a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22245", "l": "kaempferol + UDP-alpha-D-xylose => H(+) + kaempferol 3-O-beta-D-xyloside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43437", "l": "coproporphyrinogen III + 3 O2 => coproporphyrin III + 3 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73311", "l": "L-thyroxine sulfate(out) = L-thyroxine sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56674", "l": "(E)-4-coumaroyl-CoA + H(+) + NADPH => dihydro-4-coumaroyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73834", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139909", "l": "Translocation of BMF to mitochondria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50988", "l": "prostaglandin F2alpha(out) = prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912627", "l": "CBL ubiquitinates PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168947", "l": "Ligand binds to TLR10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31244", "l": "H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) => (4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34935", "l": "2 ATP + H(+) = diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193669", "l": "TRAF6 binds to p75NTR:NRIF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57996", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose = (20S)-ginsenoside Rh2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047480", "l": "UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52069", "l": "9-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.093101469280398", "identifiers": [{"i": "GO:0140102", "l": "catalytic activity, acting on a rRNA", "d": ["Catalytic activity that acts to modify a ribosomal RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73138", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine <=> 4',7-dihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10660", "l": "L-seryl-[protein] = D-seryl-[protein]", "d": []}, {"i": "EC:5.1.1.16", "l": "\"protein-serine epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33213", "l": "2-demethylmenaquinol-7 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42657", "l": "diphthine methyl ester-[translation elongation factor 2] + H2O => diphthine-[translation elongation factor 2] + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61984", "l": "H(+) + NADH + ubiquinone-10 = NAD(+) + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028519", "l": "NTRK2-activated PI3K generates PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20420", "l": "coelenterazine + O2 <=> CO2 + coelenteramide + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004917", "l": "interleukin-7 receptor activity", "d": ["Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.12", "l": "\"lachrymatory-factor synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60837", "l": "a 5'-end diphospho-adenosine in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54048", "l": "(2E,6E)-farnesyl diphosphate + H2O = 4-epi-cubebol + diphosphate", "d": []}, {"i": "EC:4.2.3.170", "l": "\"4-epi-cubebol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71489", "l": "L-phenylalanyl-L-leucine + L-tyrosylglycylglycine => H2O + Leu-enkephalin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013110", "l": "RHOC binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69999", "l": "L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983011", "l": "Expression of STAT5 upregulated genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38226", "l": "(9Z)-octadecenoyl-CoA + decan-1-ol <=> 1-O-decyl-(9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617660", "l": "ROS oxidize FOXO4 cysteine residues (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031768", "l": "ghrelin receptor binding", "d": ["Binding to a ghrelin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35443", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose = an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP", "d": []}, {"i": "EC:2.4.2.51", "l": "\"anthocyanidin 3-O-glucoside 2'''-O-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9028730", "l": "Activated NTRK2 binds FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371527", "l": "HSF1 trimer translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033413", "l": "UGU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UGU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443817", "l": "Phosphorylation of L1 by EPHB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209903", "l": "Noradrenaline is converted to adrenaline (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67287", "l": "(2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione <=> (1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990882", "l": "CDK1 phosphorylates NUP98 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35995", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013109", "l": "RHOC GEFs activate RHOC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72598", "l": "H(+)(out) + N-acetyl-L-aspartyl-L-glutamate(out) <=> H(+)(in) + N-acetyl-L-aspartyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51016", "l": "7,8-dihydroneopterin 3'-phosphate = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate", "d": []}, {"i": "EC:4.1.2.59", "l": "\"dihydroneopterin phosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373748", "l": "SEMA4D interacts with CD72 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917696", "l": "Cargo Sequestration (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419351", "l": "PAF receptor binds platelet activating factor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592270", "l": "NID1 degradation by MMP1, 9, 12, ELANE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.-", "l": "\"Hydro-lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800870", "l": "NDUF subunits bind to form the FP subcomplex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33675", "l": "H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) = H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32429", "l": "(S)-carvone + AH2 => (1R,4S)-isodihydrocarvone + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36494", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA <=> (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36851", "l": "(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69540", "l": "GTP + streptomycin = 6-O-guanylylstreptomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25382", "l": "2-hydroxy-3-methylhexadecanoyl-CoA <=> 2-methylpentadecanal + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45888", "l": "12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33080", "l": "6-amino-6-deoxyfutalosine + H2O => adenine + dehypoxanthine futalosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19912", "l": "(S)-lactate + 2 Fe(III)-[cytochrome c] <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27342", "l": "AH2 + NH4(+) + O2 => A + H(+) + H2O + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48639", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418662", "l": "Src activation following P2Y purinoceptor activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54940", "l": "(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404144", "l": "Parenchymal atROL translocates to HSCs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56401", "l": "[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36410", "l": "ATP + hydrogencarbonate + L-threonine <=> diphosphate + H2O + L-threonylcarbamoyladenylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70728", "l": "3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O => 6-sulfo-alpha-D-quinovose + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606807", "l": "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72833", "l": "G[3'-5']pAp[3'] + H(+) => 3',3'-cGAMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50507", "l": "acetyl-CoA + N-terminal L-seryl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15102", "l": "H(+) + meso-2,6-diaminoheptanedioate => CO2 + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865275", "l": "PDGF-BB clevage by Furin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33575", "l": "an inositol-1-phosphophytoceramide + beta-D-mannose = a mannosylinositol-1-phosphophytoceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5221061", "l": "TDG excises 5-carboxylcytosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043125", "l": "ErbB-3 class receptor binding", "d": ["Binding to the protein-tyrosine kinase receptor ErbB-3/HER3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102926", "l": "solanidine glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + solanidine = H+ + gamma-chaconine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170674", "l": "Dissociation of the Gi alpha:G olf complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21595", "l": "(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) <=> H(+) + L-2-aminopentanoate + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210439", "l": "glutamate uptake by astrocytes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035960", "l": "Defective CYP27A1 does not 27-hydroxylate 5β-CHOL3α,7α,24(s)-triol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71504", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(in) => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22529", "l": "a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose => a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12088", "l": "an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.80", "l": "\"ceramide glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64118", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173626", "l": "Activation of C1r (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9815510", "l": "MIB2 binds CYLD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.351", "l": "\"phosphogluconate dehydrogenase [NAD(P)(+)-dependent, decarboxylating]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.20.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878054", "l": "HIPK2 phosphorylates RUNX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5218821", "l": "PDK1 phosphorylates PKC (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9656891", "l": "OPN1SW binds 11cRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68430", "l": "(3R)-3-hydroxy-10'-apo-beta-carotenal + (3R,6R)-hydroxy-alpha-ionone => lutein + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15240", "l": "2 Fe(III)-[cytochrome c2] + NADPH <=> 2 Fe(II)-[cytochrome c2] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445089", "l": "Dephosphorylation of pL1 (Y1176) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804383", "l": "PRMT5 methylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72041", "l": "nicotinate(out) + orotate(in) => nicotinate(in) + orotate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45922", "l": "4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA => 16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38809", "l": "1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787594", "l": "TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033505", "l": "PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38494", "l": "2-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50369", "l": "2-methylbutan-2-ol + H(+) + NADPH + O2 => 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090614", "l": "5'-methylthioadenosine deaminase activity", "d": ["Catalysis of the reaction: 5'methyl thioadenosine + H2O = 5'methyl thioinosine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247569", "l": "PADI4 deiminates Histones (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71371", "l": "epitestosterone 17-sulfate(out) + 2 Na(+)(out) = epitestosterone 17-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853405", "l": "TPX2 binds AURKA at centrosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11213", "l": "indole + O2 => 2-formamidobenzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57420", "l": "NADH + 2 oxidized [cytochrome P450] = H(+) + NAD(+) + 2 reduced [cytochrome P450]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213017", "l": "Auto-ubiquitination of TRAF3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47237", "l": "eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050167", "l": "pantothenoylcysteine decarboxylase activity", "d": ["Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine + H+ = (R)-pantetheine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730858", "l": "Autophosphorylation of BTK/ITK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28093", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022942", "l": "GAD2 gene expression is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854303", "l": "TBC1D11 binds RAB6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61574", "l": "(15S)-hydroperoxy-(11Z,13E)-eicosadienoate => (11Z,14Z)-eicosadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33433", "l": "(3E)-2-oxohex-3-enedioate => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31427", "l": "(2E,6E)-farnesyl diphosphate = (1S,5S,6R)-alpha-bergamotene + diphosphate", "d": []}, {"i": "EC:4.2.3.81", "l": "\"exo-alpha-bergamotene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070678", "l": "preprotein binding", "d": ["Binding to a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18357", "l": "NADP(+) + tropine = H(+) + NADPH + tropinone", "d": []}, {"i": "EC:1.1.1.206", "l": "\"tropinone reductase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61378", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27365", "l": "bromide + S-adenosyl-L-methionine = bromomethane + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395764", "l": "atREs binds to nascent CM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0051723", "l": "protein methylesterase activity", "d": ["Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol."]}, {"i": "REACT:R-HSA-5367022", "l": "DPH7 hydrolyzes a methyl group on Me-diphthine EEF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39195", "l": "3-oxotetracosanoyl-CoA + H(+) + NADPH = (3R)-hydroxytetracosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047732", "l": "CDP-abequose epimerase activity", "d": ["Catalysis of the reaction: CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9733960", "l": "Bile salts and acids dissociate from ALB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29025", "l": "H(+)(out) + L-fucose(out) => H(+)(in) + L-fucose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254251", "l": "ERBB4s80 binds YAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12748", "l": "a 1,4-lactone + H2O <=> a 4-hydroxyacid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034816", "l": "anthracene 9,10-dioxygenase activity", "d": ["Catalysis of the reaction: anthracene + 2 H2O = cis-9,10-dihydroanthracene-9,10-diol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373732", "l": "Nephrin trans-homophilic interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35310", "l": "H(+) + NADH + O2 + salicylate <=> 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10646", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+) => 2-oxo-2H-pyran-4,6-dicarboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40170", "l": "hexadecanoyl-CoA + O2 <=> (2E)-hexadecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6799350", "l": "Exocytosis of specific granule membrane proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875183", "l": "CBL monoubiquitinates activated MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5432825", "l": "HMGB1 binds TLR4:LY96 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18048", "l": "6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O <=> alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77094", "l": "Formation of cap binding complex (CBC) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804229", "l": "JMY, TTC5 and EP300 bind (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029690", "l": "Caspase-6 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9681616", "l": "AP2 binds chlorpromazine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0034987", "l": "immunoglobulin receptor binding", "d": ["Binding to one or more specific sites on an immunoglobulin receptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023455", "l": "Autocatalytic phosphorylation of FGFR1c P252X mutant dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5674385", "l": "p-T,Y MAPKs dimerize (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69802", "l": "D-tryptophanyl-tRNA(Trp) + H2O <=> D-tryptophan + tRNA(Trp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5591086", "l": "SERPINA5 binds activated protein C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18264", "l": "H2O + precorrin-5 + S-adenosyl-L-methionine <=> acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48670", "l": "20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43214", "l": "2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043795", "l": "glyceraldehyde oxidoreductase activity", "d": ["Catalysis of the reaction: A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72349", "l": "3-methoxyphenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + veratrole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59225", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + hydropyrene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050184", "l": "phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: An oleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a linoleoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65755", "l": "2-oxoglutarate + L-glutamate + O2 <=> (3R)-3-hydroxy-L-glutamate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69031", "l": "5beta-dihydrotestosterone + H(+) + NADPH <=> 5beta-androstane-3alpha,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19318", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate => 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000822", "l": "inositol hexakisphosphate binding", "d": ["Binding to inositol hexakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65073", "l": "(2E,6E)-farnesyl diphosphate => dauca-4,7-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061628", "l": "H3K27me3 modified histone binding", "d": ["Binding to a histone H3 in which the lysine residue at position 27 has been modified by trimethylation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13964", "l": "ATP + H2O + Mg(2+) + protoporphyrin IX <=> ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28985", "l": "nitrite(out) => nitrite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047167", "l": "1-alkyl-2-acetylglycerol O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-O-alkyl-2-acetyl-sn-glycerol + acyl-CoA = 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32980", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O => a fatty acid + H(+) + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45923", "l": "16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36002", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928591", "l": "EPH:EFN tetramers oligomerise (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13109", "l": "2-acetamidofluorene + H2O + NAD(+) = H(+) + N-hydroxy-2-acetamidofluorene + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70982", "l": "Fumarate + H2O <=> (S)-Malate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59635", "l": "D-xylobiose + O2 <=> D-xylobiono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.24", "l": "\"(E3-independent) E2 ubiquitin-conjugating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035517", "l": "Defective AVP mutants do not bind AVPR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74885", "l": "GUCYs converts GTP to cGMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68720", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 26-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003848", "l": "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0016901", "l": "oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule."]}, {"i": "EC:1.1.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18020", "l": "H(+) + indole-3-pyruvate <=> CO2 + indole-3-acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.149", "l": "\"20alpha-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8962039", "l": "TK1 gene expression is stimulated by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389381", "l": "Gads binds CD28 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54832", "l": "a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] = a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.48", "l": "\"jasmonoyl-L-amino acid 12-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22879", "l": "(R)-mandelamide + H2O <=> (R)-mandelate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37753", "l": "2-methyl-cis-aconitate => 2-methyl-trans-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24301", "l": "2 cob(I)yrinate a,c diamide + FMN + 3 H(+) => 2 cob(II)yrinate a,c diamide + FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004152", "l": "dihydroorotate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23326", "l": "ADP-alpha-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide => 2'-phospho-[ligated tRNA] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33631", "l": "ATP + CoA + octanoate = AMP + diphosphate + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69107", "l": "2-oxo-3-sulfanylpropanoate + L-kynurenine <=> H2O + kynurenate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18873", "l": "3-chloro-D-alanine + H2O = chloride + H(+) + NH4(+) + pyruvate", "d": []}, {"i": "EC:4.5.1.2", "l": "\"3-chloro-D-alanine dehydrochlorinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086410", "l": "CDK1 phosphorylates BORA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660538", "l": "Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.81", "l": "\"flavone 7-O-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23159", "l": "(E)-(indol-3-yl)acetaldehyde oxime <=> (indol-3-yl)acetonitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57455", "l": "L-glutaminyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390425", "l": "FAR1 reduces PalmCoA to HXOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047590", "l": "5-dehydro-2-deoxygluconokinase activity", "d": ["Catalysis of the reaction: ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043741", "l": "alpha-aminoadipate acetyltransferase activity", "d": ["Catalysis of the reaction: alpha-aminoadipate + acetyl-CoA = N2-acetyl-alpha-aminoadipate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52231", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + biliverdin beta + CO + Fe(2+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51441", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41079", "l": "1-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655440", "l": "CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61084", "l": "(2S)-naringenin + 2-oxoglutarate + O2 = (2R,3R)-dihydrokaempferol + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669023", "l": "TWEAK binds FN14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73423", "l": "L-asparagine(out) = L-asparagine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12483", "l": "5-aminolevulinate + pyruvate <=> 4,5-dioxopentanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216136", "l": "Formation of the CI:SU(FU) complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604368", "l": "Autocatalytic activation of bound proMMP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008015", "l": "RUNX2 binds STAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23007", "l": "a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine <=> a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65990", "l": "calciol => previtamin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.12.1", "l": "\"dual-specificity kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25123", "l": "H(+) + H2O + L-1-piperideine-6-carboxylate => (S)-2-amino-6-oxohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033924", "l": "dextran 1,6-alpha-isomaltotriosidase activity", "d": ["Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in dextrans, to remove successive isomaltotriose units from the non-reducing ends of the chains."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72301", "l": "3,3',5-triiodo-L-thyronine(in) + L-glutamate(out) => 3,3',5-triiodo-L-thyronine(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.112", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56404", "l": "[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51006", "l": "an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H(+) => a primary alcohol + 2 Fe(III)-[cytochrome cL]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16415", "l": "(R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + L-lysyl-[glycine-cleavage complex H protein] => (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + L-lysyl-[lipoyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-500717", "l": "Activation of GRIK3 homomer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400143", "l": "Fatty acid ligands activate PPARA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61042", "l": "(+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050028", "l": "L-lysine-lactamase activity", "d": ["Catalysis of the reaction: L-2-aminohexano-6-lactam + H2O = L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66826", "l": "2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate => 2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38459", "l": "2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA = 2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA", "d": []}, {"i": "EC:2.3.1.278", "l": "\"mycolipenoyl-CoA--2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821366", "l": "AKAP8L binds MLL2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003959", "l": "NADPH dehydrogenase activity", "d": ["Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39898", "l": "7-deoxyloganetate + UDP-alpha-D-glucose <=> 7-deoxyloganate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0140410", "l": "monoatomic cation:bicarbonate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49427", "l": "ATP + validone <=> ADP + H(+) + validone 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964773", "l": "OXGR1 binds 2OG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21078", "l": "CO2 + succinate + uridine => 2'-deoxyuridine + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39664", "l": "a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32158", "l": "7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine <=> adenine + epoxyqueuosine(34) in tRNA + 2 H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938217", "l": "RUNX1 binds the SWI/SNF complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029454", "l": "Autophosphorylation of PAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29649", "l": "alpha-D-glucose 1-phosphate + alpha-maltotetraose => alpha-maltopentaose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35908", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30779", "l": "D-gluconate + FAD + H(+) = 2-dehydro-D-gluconate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73932", "l": "Resynthesis of excised residue by POLB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32480", "l": "2 iodide + L-tyrosine + 2 NADP(+) => 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72884", "l": "2 3-phenylpyruvate + 2 ATP => 2 AMP + 2 diphosphate + H(+) + polyporic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944261", "l": "Association of procollagen type XIII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195251", "l": "Assembly of the destruction complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20249", "l": "L-alanine = D-alanine", "d": []}, {"i": "EC:5.1.1.1", "l": "\"alanine racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53234", "l": "(24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => desmosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8857686", "l": "FITM1, FITM2 bind TAGs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877192", "l": "RUNX1 binds FOXP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30102", "l": "1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45543", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757954", "l": "N4BP1 binds IKBKG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70845", "l": "L-arginine(out) + L-methionine(in) + Na(+)(in) => L-arginine(in) + L-methionine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34116", "l": "carboxynorspermidine + H2O + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20116", "l": "beta-D-glucose 1-phosphate <=> beta-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37039", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 = 5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46240", "l": "a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080068", "l": "5-methylthiopentyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 5-methylthiopentyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 5-methylthiopentyl-glucosinolate + adenosine 3',5'-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57867", "l": "indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391934", "l": "DP2 receptor can bind PGD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49099", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine <=> 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782943", "l": "UV-DDB ubiquitinates XPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64726", "l": "(7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate => (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40955", "l": "(R)-5-phosphomevalonate + ATP = ADP + CO2 + isopentenyl phosphate + phosphate", "d": []}, {"i": "EC:4.1.1.99", "l": "\"phosphomevalonate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25557", "l": "9alpha-copalyl diphosphate => diphosphate + stemod-13(17)-ene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788623", "l": "p-Y-STATs translocate to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202241", "l": "Recruitment of SLP-76 to Gads (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15301", "l": "D-apiitol + NAD(+) = aldehydo-D-apiose + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.114", "l": "\"apiose 1-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109862", "l": "MAP2K2 phosphorylates MAPK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202127", "l": "eNOS synthesizes NO (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061686", "l": "hercynylcysteine sulfoxide synthase activity", "d": ["Catalysis of the reaction: L-cysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (hercynine) + O2 = hercynylcysteine sulfoxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007882", "l": "IL1F10 is cleaved (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62921", "l": "1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol => 1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18544", "l": "10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine <=> dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12954", "l": "ATP + L-seryl-[Goodpasture antigen-binding protein] => ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013438", "l": "RHOD binds effectors at the endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12400", "l": "beta-nicotinamide D-ribonucleotide + H2O = NH4(+) + nicotinate beta-D-ribonucleotide", "d": []}, {"i": "EC:3.5.1.42", "l": "\"nicotinamide-nucleotide amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.48", "l": "\"cerevisin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69005", "l": "Cdc6 protein is phosphorylated by CDK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847880", "l": "CYTH proteins bind ARF1:GTP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451347", "l": "Activation of JNK by DSCAM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350578", "l": "NQO1 interaction with ODC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16569", "l": "2-oxoglutarate + L-lysyl-[collagen] + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.4", "l": "\"procollagen-lysine 5-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549424", "l": "Expression of CCRN4L (NOCTURNIN) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139905", "l": "Translocation of activated BAD protein to mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68603", "l": "ORC5 binds ORC2:ORC3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73700", "l": "ADP(in) + dATP(out) => ADP(out) + dATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44185", "l": "D-sedoheptulose 7-phosphate => 2-epi-5-epi-valiolone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675947", "l": "TNFSF18 binds TNFRSF18 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65958", "l": "ADP + estrone 3-sulfate(in) + H(+) + phosphate => ATP + estrone 3-sulfate(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24962", "l": "[excited state blue fluorescent protein] + CO2 => apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54397", "l": "1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19491", "l": "2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+) => dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14511", "l": "3-epihydroxymugineate + CO2 + H(+) + succinate => 2-oxoglutarate + mugineate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33700", "l": "C20 sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54008", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782286", "l": "METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875591", "l": "DOCK7 activates RAC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64823", "l": "2-phenylacetamide + H2O <=> 2-phenylacetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712083", "l": "ALK mutants bind PI3KCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30286", "l": "(-)-trans-permethrin + H2O <=> (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31781", "l": "13-cis-retinol + a fatty acid + H(+) => an all-trans-retinyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48502", "l": "glycerol + H(+) + octanoate => H2O + octanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191402", "l": "Reduction of presqualene diphosphate to form squalene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19235", "l": "H(+) + hexadecanoate + L-cysteinyl-[protein] => H2O + S-hexadecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75889", "l": "ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) => ADP-1-deoxy-1,O(4)-didehydro-D-ribose + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449829", "l": "IL11 binds IL11RA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19871", "l": "an N-acylglycine + CoA + H(+) => an acyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41689", "l": "1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29464", "l": "K(+)(in) => K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030773", "l": "6-hydroxymellein O-methyltransferase activity", "d": ["Catalysis of the reaction: 6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140827", "l": "zinc chaperone activity", "d": ["Binding to and delivering zinc ions to a target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193695", "l": "IRAK interacts with TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73592", "l": "CTP(out) + dUTP(in) => CTP(in) + dUTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12194", "l": "(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66841", "l": "asperterpenoid A + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => asperterpenoid B + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653936", "l": "Formation of Ragulator complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70641", "l": "2''-O-hexanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-hexanoyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28040", "l": "[thioredoxin]-dithiol + CDP => [thioredoxin]-disulfide + dCDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12789", "l": "an alditol + NADP(+) = an aldose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964561", "l": "The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds MYBL2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30046", "l": "fumarate + L-aspartate <=> iminosuccinate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17536", "l": "2-oxoglutarate + an aromatic L-alpha-amino acid <=> an aromatic oxo-acid + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140761", "l": "sequestered tissue factor -> tissue factor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39490", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA <=> (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201603", "l": "Caspase-mediated cleavage of PKC theta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42067", "l": "ATP + GTP <=> 2',3'-cGAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25381", "l": "2-methylpentadecanal + formyl-CoA => 2-hydroxy-3-methylhexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67953", "l": "an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy-very-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015571", "l": "N-acetylgalactosamine transmembrane transporter activity", "d": ["Enables the transfer of N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784462", "l": "TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802925", "l": "Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022873", "l": "protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + maltose(out) = protein histidine + maltose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22241", "l": "H2O + methylenediurea => N-(carboxyaminomethyl)urea + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730886", "l": "Phosphorylation of SHC by SYK kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30344", "l": "FAD + H(+) + succinate => FADH2 + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196929", "l": "FLAD1 phosphorylates FMN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52531", "l": "2-oxoglutarate + L-asparagine <=> 2-oxosuccinamate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70075", "l": "acetyl-CoA + AH2 + H(+) + 3 malonyl-CoA + 2 S-adenosyl-L-methionine = A + clavatol + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391941", "l": "BLT receptors can bind LTB4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68938", "l": "AMP + diphosphate + NADP(+) + nonanal => ATP + H(+) + NADPH + nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27679", "l": "ATP + dCDP => ADP + dCTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9658253", "l": "RAS:GTP binds PI3K (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11675", "l": "chorismate + L-glutamine <=> 4-amino-4-deoxychorismate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12560", "l": "hydroquinone + UDP-alpha-D-glucose = H(+) + hydroquinone O-beta-D-glucopyranoside + UDP", "d": []}, {"i": "EC:2.4.1.218", "l": "\"hydroquinone glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000121", "l": "glycerol-1-phosphatase activity", "d": ["Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399939", "l": "Autophosphorylation of PAK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9009072", "l": "STAT3 phosphorylation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446221", "l": "Mannose-1-phosphate converted to GDP-Mannose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0090490", "l": "L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)", "d": ["Catalyzes the reaction: L-Tryptophan + Oxygen + NADPH + H+ = N-Hydroxy-L-tryptophan + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624951", "l": "TNPO1 binds KIF17 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41382", "l": "4-methylphenol + H2O + NAD(+) => H(+) + NADH + O2 + toluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50012", "l": "H(+) + NADPH + O2 + tert-butanol = 2-methylpropane-1,2-diol + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.229", "l": "\"tert-butanol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216045", "l": "Collagen type I binds integrin alpha11beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607043", "l": "factor VIIIa associates with cell membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12198", "l": "acetyl phosphate + D-erythrose 4-phosphate + H2O => keto-D-fructose 6-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51838", "l": "(9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905762", "l": "CCR4-NOT complex binding", "d": ["Binding to a CCR4-NOT complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73478", "l": "D-arginine(in) + L-ornithine(out) <=> D-arginine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168136", "l": "NOTCH3 binds DLL4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5660980", "l": "p-S276-RELA binds RELB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71559", "l": "5-N(alpha)-glycyl-dTMP in DNA + A + H2O = 5-aminomethyl-dUMP in DNA + AH2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027631", "l": "5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55216", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + rhizathalene A", "d": []}, {"i": "EC:4.2.3.195", "l": "\"rhizathalene A synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189439", "l": "ALAD condenses 2 dALAs to form PBG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56342", "l": "ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211289", "l": "MAFA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54460", "l": "1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42186", "l": "17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH => 5alpha-androstane-3beta,17beta-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15425", "l": "coproporphyrinogen III + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX", "d": []}, {"i": "EC:1.3.98.3", "l": "\"coproporphyrinogen dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961946", "l": "E2F1 binds the CDT1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60484", "l": "CTP + UTP = cyclic CMP-UMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17290", "l": "beta-D-fructose 2,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23392", "l": "(n-1) H2O + RNA(n) = n a ribonucleoside 5'-phosphate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25932", "l": "4-methylquinoline + A + H2O = 4-methylquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10670", "l": "1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210277", "l": "Interaction of PECAM-1 and SHP-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73813", "l": "L-proline(out) => L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29535", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}, {"i": "EC:2.4.1.260", "l": "\"dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203130", "l": "OLR1 binds to oxidized LDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944457", "l": "MAF1 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32884", "l": "(11R)-dihydroartemisinic aldehyde + NADP(+) => (+)-artemisinic aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432067", "l": "Aquaporin-4 passively transports water out of cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24026", "l": "(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine => (2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209792", "l": "N-acetylation of serotonin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51720", "l": "ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24110", "l": "2-oxoglutarate + methylamine => H2O + N-methyl-2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168400", "l": "iE-DAP elicits a NOD1 response (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27992", "l": "1-deoxy-D-xylulose 5-phosphate + ADP + H(+) => 1-deoxy-D-xylulose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38580", "l": "dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30378", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-thujopsene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2002401", "l": "Association of procollagen type XVIII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40709", "l": "1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801109", "l": "CHM binds RGGT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035798", "l": "2-alkenal reductase (NADP+) activity", "d": ["Catalysis of the reaction: n-alkanal + NADP+ = alk-2-enal + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009362", "l": "Proteasome degrades PolyUb-RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46157", "l": "15,9'-di-cis-phytofluene + a plastoquinone => 9,9',15-tri-cis-zeta-carotene + a plastoquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68506", "l": "(Z)-beta-farnesene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43352", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56509", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640862", "l": "Tankyrase binds AXIN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004593", "l": "pantothenase activity", "d": ["Catalysis of the reaction: (R)-pantothenate + H2O = (R)-pantoate + beta-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23014", "l": "a fatty acid methyl ester + S-adenosyl-L-homocysteine => a fatty acid + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32226", "l": "(6S)-NADHX + ADP <=> AMP + H(+) + NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74035", "l": "D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33626", "l": "ATP + CoA + dodecanoate <=> AMP + diphosphate + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19381", "l": "(S)-oxalosuccinate + H(+) = 2-oxoglutarate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602454", "l": "proMMP9 binds TIMP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197963", "l": "DHFR2 reduces FOLA to DHF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9660192", "l": "VDR agonists bind VDR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43343", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814088", "l": "SYS1 binds AcM-ARFRP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10356", "l": "3alpha-hydroxy-5beta-androstan-17-one + NAD(+) = 5beta-androstane-3,17-dione + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.152", "l": "\"3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666001", "l": "Profilin:G-actin binds MKL1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23010", "l": "D-glucose + D-glucose 6-phosphate => alpha,alpha-trehalose 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51540", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.51", "l": "\"(S)-corytuberine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019535", "l": "ferric-vibriobactin transmembrane transporter activity", "d": ["Enables the transfer of ferric-vibriobactin ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59096", "l": "monoglucosyl-enterobactin + UDP-alpha-D-glucose = diglucosyl-enterobactin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71238", "l": "[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] <=> [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247849", "l": "WLS dissociates from retromer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018477", "l": "benzaldehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047463", "l": "2-aminohexano-6-lactam racemase activity", "d": ["Catalysis of the reaction: L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27856", "l": "3-geranyl-4-hydroxybenzoate + diphosphate => (2E)-geranyl diphosphate + 4-hydroxybenzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9615249", "l": "ARBs bind AGRT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23190", "l": "3-hydroxypropanal + H(+) + NADH => NAD(+) + propane-1,3-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111237", "l": "Formation of ADAR1 homodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047806", "l": "cytochrome-c3 hydrogenase activity", "d": ["Catalysis of the reaction: 2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72961", "l": "(R)-3-hydroxybutanoate(in) + 2 Na(+)(in) => (R)-3-hydroxybutanoate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628444", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8943279", "l": "GGT dimers hydrolyse GSH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68510", "l": "(Z)-beta-farnesene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052915", "l": "23S rRNA (guanine(2445)-N(2))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(2445) in 23S rRNA = N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57882", "l": "3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP => 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36477", "l": "(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36011", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868118", "l": "MAPK12 phosphorylates PTPN3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53114", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH => 3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53137", "l": "(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) => 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33888", "l": "(-)-secoisolariciresinol + 2 NAD(+) => (-)-matairesinol + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59750", "l": "CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein] => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56904", "l": "an acyl-AMP + CoA = AMP + an acyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390438", "l": "FAR2 reduces PalmCoA to HXOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34926", "l": "nitrate(in) <=> nitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783681", "l": "LIF binds LIFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69926", "l": "castasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> brassinolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16782", "l": "a fatty acyl-CoA + H2O => a fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876472", "l": "NPC2 binds CHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48821", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 => 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784189", "l": "JAKs bind LIFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757454", "l": "ST translocates from cytosol to mitochondrial matrix of hepatocytes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50320", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39371", "l": "3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.21", "l": "\"clavaminate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13154", "l": "(R)-glycerate + CO2 + NAD(+) => 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-425861", "l": "Activation of Protein Kinase C novel isoforms (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000348", "l": "RANBP2 SUMOylates SP100 with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21710", "l": "adenosine + L-homocysteine => H2O + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018814", "l": "RHOT1 hydrolyzes GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63170", "l": "S-(2-succino)-L-cysteine => fumarate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060308", "l": "GTP cyclohydrolase I regulator activity", "d": ["Binds to and modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34370", "l": "acrylamide + H2O <=> acrylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29795", "l": "ATP(in) + H2O(in) + Zn(2+)(out) = ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)", "d": []}, {"i": "EC:7.2.2.20", "l": "\"ABC-type Zn(2+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622572", "l": "NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59776", "l": "D-arabinitol + O2 = D-arabinose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15752", "l": "(S)-mandelate + A <=> AH2 + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15420", "l": "L-arogenate + NADP(+) <=> CO2 + L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19612", "l": "adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001646", "l": "cAMP receptor activity", "d": ["Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203979", "l": "Coat Assembly (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61238", "l": "4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+) => H2O + L-methionine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37221", "l": "3-methyl-2-oxobutanoate + AH2 + NH4(+) => A + D-valine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70821", "l": "L-homoarginine(out) + L-ornithine(in) => L-homoarginine(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45312", "l": "NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186798", "l": "GAP binds to PDGF-beta receptors only (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19970", "l": "hydroxylamine + O2 => H(+) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004430", "l": "1-phosphatidylinositol 4-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24846", "l": "2 isomaltose => cyclobis-(1->3)-alpha-D-isomaltosyl + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17117", "l": "ATP + L-glutamate + methylamine = ADP + H(+) + N(5)-methyl-L-glutamine + phosphate", "d": []}, {"i": "EC:6.3.4.12", "l": "\"glutamate--methylamine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712204", "l": "ANO2:Ca2+ translocates Cl- from the cytosol to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47158", "l": "7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH => 7alpha,25-dihydroxycholesterol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43365", "l": "L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose => beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371435", "l": "Constitutive phosphorylation by GSK3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874083", "l": "p-Y397-PTK2 binds SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22096", "l": "phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)", "d": []}, {"i": "EC:2.7.7.8", "l": "\"polyribonucleotide nucleotidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429730", "l": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372910", "l": "pyruvate + NADH + H+ <=> lactate + NAD+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13744", "l": "3-phenylpyruvate + L-tryptophan <=> indole-3-pyruvate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24951", "l": "3-hydroxy-3-methylglutarate + malonyl-CoA <=> (3S)-hydroxy-3-methylglutaryl-CoA + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694265", "l": "nsp13 helicase melts secondary structures in SARS-CoV-2 genomic RNA template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61272", "l": "H2O + L-2-aminopentanoate + O2 = 2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990757", "l": "ubiquitin ligase activator activity", "d": ["Binds to and increases the activity of a ubiquitin ligase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52025", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 => 18S-resolvin E2 + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32492", "l": "alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32830", "l": "ATP + H2O + methionine(out) <=> ADP + H(+) + methionine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12168", "l": "allyl alcohol + NADP(+) = acrolein + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.54", "l": "\"allyl-alcohol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399930", "l": "Activation of PAK by Rac1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047413", "l": "N(alpha)-benzyloxycarbonylleucine hydrolase activity", "d": ["Catalysis of the reaction: N-benzyloxycarbonyl-L-leucine + H2O + H+ = L-leucine + benzyl alcohol + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72697", "l": "Start codon recognition (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.57", "l": "\"caspase-4\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140740", "l": "ADP-riboxanase activity", "d": ["Catalysis of the reaction: L-arginyl-[protein] + NAD+ = ADP-riboxanated L-argininyl-[protein] + H+ + NH4(+) + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22365", "l": "L-quinate + NAD(+) => 3-dehydroquinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19301", "l": "histamine + S-adenosyl-L-methionine = H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.8", "l": "\"histamine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9035227", "l": "TXN2 binds CysS248-MPST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29683", "l": "alpha-maltohexaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltopentaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66636", "l": "(2E,6E)-farnesyl diphosphate + H2O = (-)-alpha-acorenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69299", "l": "CDT1 binds geminin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109862", "l": "MAP2K2 phosphorylates MAPK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15163", "l": "H2O + homogentisate + NAD(+) => 4-hydroxyphenylacetate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850945", "l": "Casein kinase II phosphorylates PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75186", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + lydicene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686587", "l": "ABL1 phosphorylates RAD52 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254290", "l": "CSN2 gene expression is stimulated by ERBB4s80:STAT5A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031882", "l": "type 5 somatostatin receptor binding", "d": ["Binding to a type 5 somatostatin receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000834", "l": "inositol heptakisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23273", "l": "an N(6)-alkylaminopurine + UDP-alpha-D-glucose => an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24203", "l": "4-aminobenzoate + H(+) <=> aniline + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60634", "l": "all-trans-4-oxoretinal + H(+) + NADH => all-trans-4-oxoretinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68518", "l": "beta-acoradiene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050227", "l": "pteridine oxidase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + unknown."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016864", "l": "intramolecular oxidoreductase activity, transposing S-S bonds", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears."]}, {"i": "EC:5.3.4.-", "l": "\"Transposing S-S bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16293", "l": "2-isopropylmaleate + H2O = (2S)-2-isopropylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39325", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+) => (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180540", "l": "Multi-ubiquitination of APOBEC3G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17229", "l": "acetyl-CoA + an aliphatic alcohol = an acetyl ester + CoA", "d": []}, {"i": "EC:2.3.1.84", "l": "\"alcohol O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448632", "l": "IL34 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14917", "l": "3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211219", "l": "Translocation of caspase-3 to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53963", "l": "4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 <=> 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11784", "l": "H2O + L-aspartate + NADP(+) = H(+) + NADPH + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46008", "l": "CoA + NAD(+) + pentanal = H(+) + NADH + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63166", "l": "taurine + tricosanoate => H2O + N-tricosanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760399", "l": "ILF3 and HOXC8 bind CDH11 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64947", "l": "dCTP + 2 H2O <=> dCMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50589", "l": "13,14-dihydro-15-oxo-PGF2alpha + NADP(+) => 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052693", "l": "epoxyqueuosine reductase activity", "d": ["Catalysis of the reaction: epoxyqueuosine in tRNA + reductant = queuosine in tRNA + oxidised reductant."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43688", "l": "N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate = L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051449", "l": "thyrotropin-releasing hormone binding", "d": ["Binding to thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67335", "l": "13-cis-retinal + H2O + NAD(+) <=> 13-cis-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112271", "l": "The receptor:G-protein complex dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0045140", "l": "inositol phosphoceramide synthase activity", "d": ["Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide + diacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61456", "l": "7-chlorotetracycline + H(+) + NADPH + O2 = (1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68615", "l": "Formation of ORC(1-6) complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45890", "l": "4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43903", "l": "dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O <=> beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19715", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37691", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865774", "l": "TTLLs polyglutamylate tubulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16725", "l": "a phosphatidylglycerol phosphate + H2O = a phosphatidylglycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68562", "l": "1-arsono-3-phospho-D-glycerate + H(+) + NADH => arsenate + D-glyceraldehyde 3-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034043", "l": "5-hydroxymethyluracil DNA N-glycosylase activity", "d": ["Catalysis of the removal of 5-hydroxymethyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21790", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51451", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50010", "l": "4-hydroxy-6-methylpretetramide + H2O + NADP(+) => 6-methylpretetramide + 2 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009208", "l": "Activated ERKs phosphorylate RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45620", "l": "H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31453", "l": "a cardiolipin + glycerol => 2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14546", "l": "H2O + nicotinamide => NH4(+) + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47385", "l": "4-acetoxyphenol + H2O => acetate + H(+) + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16469", "l": "(R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41105", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+) => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72149", "l": "3'-deoxy-3',4'-didehydro-UTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine => AH2 + S-adenosyl-L-methionine + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139898", "l": "Caspase-8 activates BID by cleavage (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710106", "l": "ELANE cleaves GSDMD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634429", "l": "CSF3R gene expression is enhanced by SPI1 (PU.1), CEBPA, and DEK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43767", "l": "ATP + chenodeoxycholate + CoA <=> AMP + chenodeoxycholoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32832", "l": "an R-cob(III)alamin(in) => an R-cob(III)alamin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003858", "l": "3-hydroxybutyrate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2318585", "l": "Defective HYAL1 does not hydrolyse Chondroitin chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790029", "l": "Expression of PTGS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508292", "l": "SYK binds IL2RB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22531", "l": "a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose <=> a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67503", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41107", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59874", "l": "3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27435", "l": "glutathione amide disulfide + H(+) + NADH => 2 glutathione amide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44861", "l": "(R)-carnitine + 4,8-dimethylnonanoyl-CoA => CoA + O-4,8-dimethylnonanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31160", "l": "(3S)-hydroxyhexadecanoyl-CoA + NAD(+) => 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59144", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005278", "l": "acetylcholine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708866", "l": "pro-F2R binds vorapaxar (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9676257", "l": "Formation of the SET1A complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57084", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989755", "l": "Expression of CYP4A11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22476", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) = 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865182", "l": "OTUD7A hydrolyses K11diUb (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49267", "l": "5-O-[(E)-caffeoyl]-shikimate + H2O <=> (E)-caffeate + H(+) + shikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928619", "l": "PAK1 binds RAC1:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299338", "l": "Activation of TRESK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6790454", "l": "SUMOylation of XPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50072", "l": "ATP + H2O + tauroursodeoxycholate(in) = ADP + H(+) + phosphate + tauroursodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44251", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10561", "l": "4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O => 2,5-dioxopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40744", "l": "(20S)-ginsenoside Rd + 2 H2O => (20S)-ginsenoside C-K + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190265", "l": "FGFR4 binds to FGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210881", "l": "Dimerization of Tie2/Ang1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11464", "l": "2 glutathione + L,L-homocystine = glutathione disulfide + 2 L-homocysteine", "d": []}, {"i": "EC:1.8.4.1", "l": "\"glutathione--homocystine transhydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69779", "l": "2-oxindole-3-acetate + succinyl-CoA = (2-oxoindol-3-yl)acetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.24", "l": "\"succinate-semialdehyde dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28547", "l": "alpha-D-glucose => alpha-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2471842", "l": "Collagen type XXV ectomain shedding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64333", "l": "ATP + CoA + nicotinate => AMP + diphosphate + nicotinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9674531", "l": "AAMP binds EGFR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9676264", "l": "Formation of the SET1B complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9670673", "l": "FIX is secreted (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1297354", "l": "Acrosin Cleavage (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40936", "l": "a 1-acylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35339", "l": "3-hydroxyicosanoyl-CoA + NADP(+) = 3-oxoeicosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170986", "l": "Ral-GDS binds to Ras-GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373732", "l": "Nephrin trans-homophilic interaction (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40500", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24636", "l": "H2 + NAD(+) = H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47336", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12849", "l": "H2O + O-phospho-L-seryl-[myosin light chain] = L-seryl-[myosin light chain] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65918", "l": "H2O + kynurenate + L-alanine => L-kynurenine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56340", "l": "ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68595", "l": "ORC2 binds ORC3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0004252", "l": "serine-type endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."]}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0015215", "l": "nucleotide transmembrane transporter activity", "d": ["Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017057", "l": "6-phosphogluconolactonase activity", "d": ["Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44856", "l": "(9Z)-octadecenoyl-CoA + (R)-carnitine = CoA + O-(9Z)-octadecenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200406", "l": "CPT1A,B transfers PALM to CAR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15313", "l": "ethanolamine = acetaldehyde + NH4(+)", "d": []}, {"i": "EC:4.3.1.7", "l": "\"ethanolamine ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70946", "l": "L-isoleucine(in) <=> L-isoleucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71531", "l": "guanine(out) = guanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56075", "l": "a 2-acylphloroglucinol + UDP-alpha-D-glucose <=> a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62202", "l": "acetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+) => ethanol + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74730", "l": "Insulin degradation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50762", "l": "a quinol + sulfate => a quinone + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52032", "l": "H2O + L-isoleucine-(+)-7-isojasmonate = (+)-7-isojasmonate + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63662", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+) => (8S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45093", "l": "H2O + N-octanoylsphing-4-enine => octanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23836", "l": "D-methionine + pyruvate = 4-methylsulfanyl-2-oxobutanoate + L-alanine", "d": []}, {"i": "EC:2.6.1.41", "l": "\"D-methionine--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67777", "l": "a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H2O => a 5'-end dephospho-2'-deoxyribonucleoside-DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61342", "l": "CO2 + propanoyl-CoA => (S)-methylmalonyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874080", "l": "SRC phosphorylates PTK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44371", "l": "Cr(6+) + 2 NADPH + O2 <=> Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043883", "l": "malolactic enzyme activity", "d": ["Catalysis of the reaction: malate + H+ = L-lactate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30573", "l": "6 AMP + 6 diphosphate + enterobactin + 4 H(+) => 3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75312", "l": "D-serine(in) + L-alanine(out) + Na(+)(out) => D-serine(out) + L-alanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703008", "l": "tamatinib-resistant FLT3 mutants don't bind tamatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3700997", "l": "TP53 binds the MDM2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72663", "l": "De novo formation of eIF2:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26516", "l": "6-oxohexanoate + H(+) => cyclohexan-1,2-dione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983422", "l": "Disassembly of COPII coated vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8931981", "l": "RUNX1 binds ESR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036041", "l": "Defective IDUA does not hydrolyse the unsulfated alpha-L-iduronosidic link in DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68404", "l": "(2R,3S)-iso(homo)2citrate + NAD(+) = 2-oxoheptanedioate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202721", "l": "JAM2 binds JAM3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863008", "l": "Calpain activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57922", "l": "H(+) + L-asparaginyl-tRNA(Asn) + phosphate => 4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55497", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604732", "l": "Autocatalytic activation of proMMP13 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17019", "l": "(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2106615", "l": "Removal of siRNA passenger strand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55051", "l": "(3E,5Z)-dodecadienoyl-CoA + H2O <=> (3E,5Z)-dodecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61655", "l": "2,3-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] <=> 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35058", "l": "3,6-dichlorocatechol + O2 <=> (2E,4E)-2,5-dichloromuconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54289", "l": "ATP + L-tyrosyl-[protein] => diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26205", "l": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.n7", "l": "\"4-nitrophenol 2-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170120", "l": "Translocation of Cdc25B to the cytoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26100", "l": "(4R)-limonene + H(+) + NADPH + O2 <=> H2O + limonene 1,2-epoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199456", "l": "PTEN dephosphorylates PIP3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850794", "l": "SPINK6 binds KLK5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606564", "l": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112156", "l": "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53761", "l": "allocholate + deoxycholoyl-CoA => allocholoyl-CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20323", "l": "1-pyrroline-2-carboxylate + H(+) + NADH => L-proline + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296127", "l": "Activation of voltage gated Potassium channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801109", "l": "CHM binds RGGT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874718", "l": "TTPA binds alpha-TOH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454916", "l": "The ABCC family mediates organic anion transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52586", "l": "7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH => chenodeoxycholoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37965", "l": "D-galactose + H(+) + NADH => galactitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71614", "l": "(S)-malate(in) + malonate(out) <=> (S)-malate(out) + malonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034799", "l": "dihydride TNP tautomerase activity", "d": ["Catalysis of the reaction: TNP dihydride Meisenheimer complex (aci form) = TNP dihydride Meisenheimer complex (nitro form)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34155", "l": "acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine = CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose", "d": []}, {"i": "EC:2.3.1.202", "l": "\"UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67862", "l": "3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806732", "l": "GNLY binds the bacterial cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12655", "l": "CO2 + NADH + pyruvate => (S)-malate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173739", "l": "Spontaneous hydrolysis of C3 thioester (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018555", "l": "phenanthrene dioxygenase activity", "d": ["Catalysis of the reaction: phenanthrene + NADH + H+ + O2 = NAD+ + cis-3,4-dihydroxy-3,4-dihydrophenanthrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39347", "l": "(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH = (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31119", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA = (2E)-2-methylbut-2-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080046", "l": "quercetin 4'-O-glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group from UDP-glucose to the 4'-hydroxy group of a quercetin molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19683", "l": "AMP + biotinyl-CoA + diphosphate => ATP + biotin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65365", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O => a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848829", "l": "CBL autoubiquitinates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60854", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33319", "l": "a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.23", "l": "\"2-hydroxypropyl-CoM lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0010277", "l": "chlorophyllide a oxygenase [overall] activity", "d": ["Catalysis of the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+; and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25244", "l": "(S)-2-ureidoglycine + H2O <=> (S)-ureidoglycolate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788622", "l": "p-Y-STATs dimerize (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70596", "l": "GOT2 dimer deaminates L-Asp (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20491", "l": "1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684140", "l": "ATM phosphorylates RBBP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63574", "l": "L-arginine + neurotensin-(1-7) => H2O + neurotensin-(1-8)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35612", "l": "menadiol + 2 O2 => 2 H(+) + menadione + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863727", "l": "STON2 is neddylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140955", "l": "histone H3K36 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl36-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl36-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102776", "l": "UDP-D-glucose:pelargonidin-3-O-beta-D-glucoside 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> anthocyanidin 3,5-di-O-beta-D-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863463", "l": "STON2 binds SYT proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44602", "l": "a fatty acyl-AMP + diphosphate => a fatty acid + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47766", "l": "2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(1369) in 16S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.57", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358791", "l": "Phosphorylation of USP8 by P-AKT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062158", "l": "chloride:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(out) + proton(in) = chloride(in) + proton(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65135", "l": "2-oxoglutarate + O2 + preaustinoid A1 <=> CO2 + H2O + preaustinoid A2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874083", "l": "p-Y397-PTK2 binds SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607058", "l": "Activated protein C:PROCR binds F2R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69074", "l": "Formation of Processive Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37422", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61178", "l": "CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside] => (E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30608", "l": "A + all-trans-phytofluene => AH2 + all-trans-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168947", "l": "Ligand binds to TLR10 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432121", "l": "LDL binds to LRP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71180", "l": "L-histidine(out) + L-tryptophan(in) => L-histidine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46701", "l": "(R)-lipoate + GTP + H(+) => (R)-lipoyl-GMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299359", "l": "Activation of TALK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14287", "l": "2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP => sn-glycerol 3-phosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004109", "l": "coproporphyrinogen oxidase activity", "d": ["Catalysis of the reaction: coproporphyrinogen III + 2 H+ + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.15", "l": "\"carboxypeptidase A2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664850", "l": "ATM binds PEX5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.7", "l": "\"heparin lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13942", "l": "ATP + D-glyceraldehyde => ADP + D-glyceraldehyde 3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55461", "l": "11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47778", "l": "2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34650", "l": "S-adenosyl-L-methionine + squalene <=> 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47293", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001406", "l": "glycerophosphodiester transmembrane transporter activity", "d": ["Enables the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34909", "l": "molybdate(out) => molybdate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62699", "l": "O2 + 4 tellimagrandin II <=> 2 cornusiin E + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27658", "l": "2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70861", "l": "L-asparagine(out) + L-glutamine(in) + Na(+)(in) => L-asparagine(in) + L-glutamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72570", "l": "dehydroepiandrosterone 3-sulfate(in) + propanoate(out) <=> dehydroepiandrosterone 3-sulfate(out) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24801", "l": "2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36139", "l": "(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031748", "l": "D1 dopamine receptor binding", "d": ["Binding to a D1 dopamine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38070", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA <=> 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.25", "l": "\"tRNA-uridine aminocarboxypropyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006507", "l": "GRIN2A gene expression is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41334", "l": "(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610722", "l": "CK1 phosphorylates p-GLI3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55984", "l": "(R)-mandelonitrile + UDP-alpha-D-glucose = (R)-prunasin + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.354", "l": "\"(R)-mandelonitrile beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982645", "l": "GRKs bind ADRB2:Catecholamine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33872", "l": "(S)-2-ureidoglycine + H2O => glyoxylate + NH4(+) + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015657", "l": "branched-chain amino acid:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: branched-chain amino acid(out) + cation(out) = branched-chain amino acid(in) + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.69", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110050", "l": "deaminated glutathione amidase activity", "d": ["Catalysis of the reaction: N-(4-oxoglutarate)-L-cysteinylglycine + H2O = 2-oxoglutarate + L-cysteinylglycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41144", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033807", "l": "icosanoyl-CoA synthase activity", "d": ["Catalysis of the reaction: stearoyl-CoA + malonyl-CoA + 2 NAD(P)H + 2 H+ = icosanoyl-CoA + CO2 + 2 NAD(P)+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42520", "l": "uridine(2605) in 23S rRNA = pseudouridine(2605) in 23S rRNA", "d": []}, {"i": "EC:5.4.99.22", "l": "\"23S rRNA pseudouridine(2605) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49314", "l": "2-trans-(+)-abscisic aldehyde + H(+) + NADH => 2-trans,4-trans-xanthoxin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31889", "l": "tirucalladienol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12674", "l": "an aliphatic amide => a nitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696356", "l": "OSCAR binds collagen and SP-D (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19968", "l": "S,S-dimethyl-beta-propiothetin <=> acrylate + dimethyl sulfide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12431", "l": "2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH <=> benzene-1,2,4-triol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692408", "l": "NPR2 binds NPPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48114", "l": "H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61341", "l": "(S)-methylmalonyl-CoA + H(+) => CO2 + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52734", "l": "adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+) => 3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030621", "l": "U4 snRNA binding", "d": ["Binding to a U4 small nuclear RNA (U4 snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66441", "l": "butan-2-one + NADP(+) => but-3-en-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57593", "l": "(S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362522", "l": "ALDHs oxidise atRAL to atRA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19699", "l": "11-cis-retinol + H(+) + hexadecanoate => 11-cis-retinyl hexadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73753", "l": "(R)-adrenaline(out) + 2 H(+)(in) => (R)-adrenaline(in) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371527", "l": "HSF1 trimer translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56631", "l": "5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O <=> chloride + 2 H(+) + maleylacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43036", "l": "L-cysteine = 2-aminoprop-2-enoate + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26161", "l": "(S)-2,3-epoxysqualene => thalianol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70971", "l": "citrate <=> isocitrate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3076905", "l": "Extracellular BTD hydrolyses BCTN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047710", "l": "bis(5'-adenosyl)-triphosphatase activity", "d": ["Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56549", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60119", "l": "2-oxoglutarate + methylphosphonate + O2 <=> CO2 + hydroxymethylphosphonate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050282", "l": "serine 2-dehydrogenase activity", "d": ["Catalysis of the reaction: L-serine + H2O + NAD+ = 3-hydroxypyruvate + NH3 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60130", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate => 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9793485", "l": "PRKN polyubiquitinates RIPK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57618", "l": "dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase] => dihydro-ML-236C-[compactin nonaketide synthase] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51490", "l": "archaetidylethanolamine + CO2 => archaetidylserine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624131", "l": "UNC119B binds myristoylated proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879930", "l": "STAT5 is recruited by JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854462", "l": "VLDLR binds VLDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18030", "l": "2 ATP + hydrogencarbonate + NH4(+) => 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18743", "l": "10-deacetylbaccatin III + CoA => 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29510", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-gurjunene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52333", "l": "2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] => 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-507868", "l": "Aquaporins passively transport water into cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139898", "l": "Caspase-8 activates BID by cleavage (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73170", "l": "CoA(out) + NAD(+)(in) <=> CoA(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38255", "l": "(S)-malate + succinyl-CoA = (S)-malyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11662", "l": "acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2328037", "l": "Fibrillin-1 binds integrins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68946", "l": "H(+) + isoscopoletin + S-adenosyl-L-homocysteine => esculetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14587", "l": "CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507719", "l": "p62:MEKK3 binds to TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.73", "l": "\"jararhagin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41706", "l": "1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26174", "l": "CoA + H(+) + mycothiol => 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810076", "l": "DDO oxidizes D-Asp to OA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851933", "l": "MET phosphorylates GAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748991", "l": "XDH oxidises 6MP to 6TU (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22807", "l": "(6S,9R)-vomifoliol + NAD(+) <=> (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72236", "l": "2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out) => 2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11886", "l": "adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+) => 3'-phosphoadenylyl sulfate + cortisol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63048", "l": "H2O + pravastatin lactone = H(+) + pravastatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10902", "l": "an aromatic oxo-acid + glycine => an aromatic L-alpha-amino acid + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32400", "l": "(1S,2R,4S)-neodihydrocarveol + NAD(+) => (1S,4S)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008921", "l": "lipopolysaccharide-1,6-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20325", "l": "N-hydroxy-4-acetylaminobiphenyl = N-acetoxy-4-aminobiphenyl", "d": []}, {"i": "EC:2.3.1.56", "l": "\"aromatic-hydroxylamine O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.-", "l": "\"Transferases for other substituted phosphate groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433501", "l": "Interaction of other adapter proteins with p-KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13864", "l": "D-xylose + NAD(+) <=> D-xylono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944230", "l": "Association of procollagen type XVIII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57167", "l": "2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 <=> (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9726580", "l": "PGR binds PGR agonists (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68357", "l": "H2O + N-acetyl-L-aspartyl-L-glutamate => L-glutamate + N-acetyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74787", "l": "L-histidyl-L-proline diketopiperazine(in) = L-histidyl-L-proline diketopiperazine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17436", "l": "A + choline <=> AH2 + betaine aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55176", "l": "2-oxoglutarate + butanoyl-CoA + O2 = 2-hydroxybutanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21044", "l": "24-methylidenelophenol + S-adenosyl-L-methionine = (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.143", "l": "\"24-methylenesterol C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112703", "l": "PTPN11 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59455", "l": "a long-chain primary fatty alcohol + NADP(+) <=> a long-chain fatty aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40223", "l": "4,8-dimethylnonanoyl-CoA + H2O = 4,8-dimethylnonanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75026", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate <=> 9-(9Z,12Z-octadecadienoyloxy)-octadecanoate + di-(9Z,12Z)-octadecadienoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60259", "l": "A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] <=> AH2 + formaldehyde + L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70774", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-381727", "l": "RAP1A exchanges GDP for GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37916", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13499", "l": "6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+) => 5-dehydro-2-deoxy-D-gluconate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35004", "l": "L-fucose(in) => L-fucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008327", "l": "methyl-CpG binding", "d": ["Binding to a methylated cytosine/guanine dinucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64477", "l": "4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate => 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46016", "l": "(20R)-20-hydroxypregn-4-en-3-one + NAD(+) = H(+) + NADH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51636", "l": "a quinone + H2O + selenite = a quinol + selenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72608", "l": "(E)-sinapoyl-AMP + CoA => (E)-sinapoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9609921", "l": "SGTA binds Tail-anchored protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69366", "l": "CoA + H(+) + N(alpha)-acetyl-6-diazo-5-oxo-L-norleucine => 6-diazo-5-oxo-L-norleucine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72617", "l": "H(+)(in) + L-alanyl-L-valine(in) => H(+)(out) + L-alanyl-L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74059", "l": "PDE6 hydrolyses cGMP to GMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050044", "l": "galactose-6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008433", "l": "RUNX2 binds CDKN1A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62610", "l": "S-sulfanylglutathione + ubiquinol-10 => glutathione + H(+) + hydrogen sulfide + ubiquinone-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62358", "l": "8-oxo-GMP + H(+) + phosphate => 8-oxo-GDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210872", "l": "Trans-phosphorylation of Tie2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46058", "l": "(11E,13Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59081", "l": "bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose => 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57305", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP => glycolate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376122", "l": "DSCAM/DSCAML1 homodimerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49138", "l": "H2O + L-methionyl-S-oxide-[protein] + NADP(+) => H(+) + L-methionyl-[protein] + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37591", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23486", "l": "AH2 + D-cellobiono-1,5-lactone => A + D-cellobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23884", "l": "nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.1", "l": "\"nicotinamide N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61533", "l": "ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72849", "l": "adenosine 3',5'-bisphosphate(out) + ADP(in) => adenosine 3',5'-bisphosphate(in) + ADP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71399", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin = 2alpha-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35699", "l": "(S)-versiconol + NADP(+) = (2S-3S)-versiconal hemiacetal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34756", "l": "H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine => D-glucose + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0005326", "l": "neurotransmitter transmembrane transporter activity", "d": ["Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019959", "l": "interleukin-8 binding", "d": ["Binding to interleukin-8."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015621", "l": "ferric triacetylfusarinine C transmembrane transporter activity", "d": ["Enables the transfer of ferric triacetylfusarinine C from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42060", "l": "11-cis-retinol + NAD(+) = 11-cis-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67933", "l": "ATP + desmosterol(in) + H2O => ADP + desmosterol(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507873", "l": "Aquaporins passively transport urea out of cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71837", "l": "estrone 3-sulfate(in) => estrone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16677", "l": "fluoroacetaldehyde + H2O + NAD(+) = fluoroacetate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.69", "l": "\"fluoroacetaldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21051", "l": "ATP + isopropylamine + L-glutamate <=> ADP + gamma-L-glutamyl-isopropylamide + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006850", "l": "IL21 receptor JAK phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247915", "l": "GSH translocates from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46064", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22568", "l": "ascopyrone M = ascopyrone P", "d": []}, {"i": "EC:5.3.2.7", "l": "\"ascopyrone tautomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31820", "l": "(2E,6E)-farnesyl diphosphate => 5-epi-alpha-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30760", "l": "5-methylcytosine + H(+) + H2O => NH4(+) + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28965", "l": "H(+)(in) + L-proline(in) => H(+)(out) + L-proline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050555", "l": "2-hydroxypropyl-CoM lyase activity", "d": ["Catalysis of the reactions: (R)-2-hydroxypropyl-CoM = H-S-CoM + (R)-1,2-epoxypropane, and (S)-2-hydroxypropyl-CoM = H-S-CoM + (S)-1,2-epoxypropane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865605", "l": "BRWD1 binds SMARCA4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14436", "l": "a tRNA precursor + ATP + 2 CTP <=> a tRNA with a 3' CCA end + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693598", "l": "ATM phosphorylates NBN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55537", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose => a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351936", "l": "Caspase-mediated cleavage of claspin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63382", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445069", "l": "L1-EGFR trans-heterodimerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20229", "l": "2,3-dihydroxybenzoate + ATP + H(+) = 2,3-dihydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35849", "l": "ADP + H(+) + sphing-4-enine 1-phosphate => ATP + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20652", "l": "23,24-dihydrocucurbitacin B + NADP(+) <=> cucurbitacin B + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.n3", "l": "\"Dictyostelium lysozyme A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102767", "l": "flavanone 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-naringenin + S-adenosyl-L-methionine = 2 H+ + ponciretin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16805", "l": "2-oxoglutarate + deacetoxycephalosporin C + O2 = CO2 + deacetylcephalosporin C + succinate", "d": []}, {"i": "EC:1.14.11.26", "l": "\"deacetoxycephalosporin-C hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659734", "l": "Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981539", "l": "C3b binds to cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25621", "l": "geranylgeranyl diphosphate = tuberculosinyl diphosphate", "d": []}, {"i": "EC:5.5.1.16", "l": "\"halimadienyl-diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694433", "l": "MIA2 binds PREB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140753", "l": "linear 1,3-beta-D-glucan synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + a linear [(1->3)-beta-D-glucosyl](n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42622", "l": "(Z)-2-methylaminoacrylate + CO2 + NH4(+) => (Z)-2-methylureidoacrylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45233", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102643", "l": "scalarane-17alpha-19-diol synthase activity", "d": ["Catalysis of the reaction: scalarane-17alpha-19-diol <=> all-trans-geranylfarnesol + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52127", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112437", "l": "Formation of NELF complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004644", "l": "phosphoribosylglycinamide formyltransferase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183051", "l": "CBL ubiquitinates Sprouty (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851011", "l": "TRIM27 polyubiquitinates PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69439", "l": "7-oxopregnenolone + H(+) + NADPH <=> 7beta-hydroxypregnenolone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70899", "l": "histidine => urocanate + NH4+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32831", "l": "an R-cob(III)alamin(in) = an R-cob(III)alamin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40923", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090554", "l": "phosphatidylcholine floppase activity", "d": ["Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}, {"i": "RHEA:38583", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24423", "l": "H2O + N-terminal N-formyl-L-methionyl-[peptide] <=> formate + N-terminal L-methionyl-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53408", "l": "(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 = (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852552", "l": "MST1R autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0140313", "l": "molecular sequestering activity", "d": ["Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."]}, {"i": "REACT:R-HSA-3245898", "l": "TCN1 binds correnoids in the circulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5615668", "l": "AKR1C3 reduces atRAL to atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66216", "l": "asc-C7-CoA + O2 = asc-DeltaC7-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617881", "l": "HOXB4 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67552", "l": "3'-phosphoadenylyl sulfate + cholate = adenosine 3',5'-bisphosphate + cholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19908", "l": "NAD(+) + spermidine <=> dehydrospermidine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61288", "l": "5-deoxy-D-ribose + ATP = 5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74072", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48472", "l": "ganglioside GT1a + H2O = ganglioside GD1a + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.253913141376358", "identifiers": [{"i": "GO:0016708", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60621", "l": "N-hexanoyl-sphing-4-enine-1-phosphocholine => choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66673", "l": "4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) => 5,7-dihydroxy-4-methylphthalide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48734", "l": "[CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74599", "l": "AMP(out) + UDP-alpha-D-galactose(in) = AMP(in) + UDP-alpha-D-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183051", "l": "CBL ubiquitinates Sprouty (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51356", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamine = (9Z)-octadecenoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40098", "l": "26-oxohexacosanoate + H2O + NAD(+) <=> 2 H(+) + hexacosanedioate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008822", "l": "PPM1D dephosphorylates RUNX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27270", "l": "CoA + hexadecanal + NADP(+) = H(+) + hexadecanoyl-CoA + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008860", "l": "ferredoxin-NAD+ reductase activity", "d": ["Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37174", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17915", "l": "H(+) + NADH + nitrate => H2O + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39169", "l": "3-oxohexadecanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605595", "l": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39649", "l": "5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+) => AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13382", "l": "acetate + an acyl-CoA => a carboxylate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64784", "l": "S-ethyl-L-cysteine = 2-aminoprop-2-enoate + ethanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612501", "l": "SGK phosphorylates CREB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60908", "l": "a cytidine in tRNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73043", "l": "creatine(in) = creatine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51283", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate <=> (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005544", "l": "calcium-dependent phospholipid binding", "d": ["Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68940", "l": "Na(+)(in) + tellurite(in) = Na(+)(out) + tellurite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507868", "l": "Aquaporins passively transport water into cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389839", "l": "39S subunit binds 28S subunit:mRNA:fMet-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694522", "l": "Inner coat assembly and cargo binding (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31850", "l": "(S)-2,3-epoxysqualene <=> shionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68991", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74258", "l": "XDH oxidizes xanthine to form urate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0015578", "l": "mannose transmembrane transporter activity", "d": ["Enables the transfer of mannose from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69315", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate <=> benzyl thiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73918", "l": "acetyl-CoA + 4 H(+) + 6 malonyl-CoA <=> 2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + 6 CO2 + 7 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58741", "l": "H2O + psi-UTP => diphosphate + H(+) + psi-UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9625482", "l": "PTK2 binds activated EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800315", "l": "MST1 binds MST1R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670412", "l": "Phosphorylation of STATs downstream of KIT mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047818", "l": "D-fuconate dehydratase activity", "d": ["Catalysis of the reaction: D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62417", "l": "(E)-4-coumaroyl-CoA + H2O => 4-hydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12959", "l": "acetate + an aliphatic alcohol + H(+) => an acetyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030943", "l": "mitochondrion targeting sequence binding", "d": ["Binding to a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61773", "l": "rebaudioside E + UDP-alpha-D-glucose => H(+) + rebaudioside D + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57121", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050131", "l": "N-methyl-L-amino-acid oxidase activity", "d": ["Catalysis of the reaction: an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15238", "l": "2 Fe(III)-[cytochrome c2] + NADPH => 2 Fe(II)-[cytochrome c2] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2299620", "l": "Collagen XI cross-links with collagen II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687107", "l": "MAPK4,6 translocate to nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211948", "l": "CYP3A4 can N-demethylate loperamide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20051", "l": "1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide => 1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20100", "l": "D-mannonate <=> 2-dehydro-3-deoxy-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102331", "l": "heptadecanoyl-[acp] elongase/decarboxylase activity", "d": ["Catalysis of the reaction: malonyl-CoA + 3 H+ + a heptodecanoyl-[acp] = octadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730840", "l": "Activation of RAC1 by VAV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16411", "l": "H(+) + NADPH + vomilenine => 1,2-dihydrovomilenine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9702849", "l": "CALCR binds gepants (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707690", "l": "BACH1 binds MAFK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42846", "l": "7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide => 6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25840", "l": "5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate", "d": []}, {"i": "EC:5.3.1.30", "l": "\"5-deoxy-glucuronate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28206", "l": "2'-deoxyuridine + ATP = ADP + dUMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199298", "l": "AKT phosphorylates CREB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941312", "l": "TUT4,TUT7 oligouridylate mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173542", "l": "SMURF2 ubiquitinates SMAD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25555", "l": "9alpha-copalyl diphosphate <=> diphosphate + stemar-13-ene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69203", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[tubulin] + L-glutamate <=> ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[tubulin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65363", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O <=> a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25604", "l": "4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O <=> 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507871", "l": "Aquaporins passively transport glycerol out of cells (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56198", "l": "H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38865", "l": "alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate => phosphate + sucrose 6(F)-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30960", "l": "9,9'-di-cis-zeta-carotene + a quinone => 7,9,9'-tri-cis-neurosporene + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68870", "l": "AMP + benzaldehyde + diphosphate + NADP(+) => ATP + benzoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607746", "l": "PKC-delta is activated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805740", "l": "SETD8 methylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45581", "l": "D-galactaro-1,5-lactone => D-galactaro-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174097", "l": "Association of Emi1 with Cdh1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199093", "l": "CXADR binds to AMICA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43637", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) => 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013145", "l": "RAC1 binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018581", "l": "hydroxyquinol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031682", "l": "G-protein gamma-subunit binding", "d": ["Binding to a G-protein gamma subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32500", "l": "(1R,5R)-sabinene + H(+) + NADPH + O2 => (1S,3R,5S)-sabinol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68794", "l": "ADP-D-ribose + H(+) + nicotinamide => alpha-NAD(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62255", "l": "2 hydrogencarbonate(out) + Zn(2+)(out) <=> 2 hydrogencarbonate(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34237", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite => 4-nitro-6-oxohepta-2,4-dienedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045322", "l": "unmethylated CpG binding", "d": ["Binding to uan nmethylated CpG motif. Unmethylated CpG dinucleotides are often associated with gene promoters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371518", "l": "SIRT1 binds to HSF1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71783", "l": "MDH2 reduces OA to MAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22894", "l": "5,10-methenyltetrahydrofolate + NADH => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65116", "l": "2-oxoglutarate + aculene B + O2 = aculene A + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9796617", "l": "MIB2 binds CFLAR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19616", "l": "dimethyl sulfide + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + trimethylsulfonium", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60567", "l": "2-deoxy-D-glucose + ATP <=> 2-deoxy-D-glucose 6-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605591", "l": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57749", "l": "2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH => C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30656", "l": "ATP + dUMP => ADP + dUDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13420", "l": "5,12-dihydroxanthommatin + NAD(+) <=> H(+) + NADH + xanthommatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27284", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+) => 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34168", "l": "2,6-dihydroxypseudooxynicotine + H2O => 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41932", "l": "H2O + hexadecanoyl-[ACP] = H(+) + hexadecanoate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046910", "l": "pectinesterase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of pectinesterase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606288", "l": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944457", "l": "MAF1 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23873", "l": "(R)-propane-1,2-diol + NAD(+) => (R)-lactaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102009", "l": "proline dipeptidase activity", "d": ["Catalysis of the reaction: H2O + a dipeptide with proline at the C-terminal <=> L-proline + a standard alpha amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813749", "l": "ALDH1A1 oxidises GA to DGA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73777", "l": "diphosphate + tardioxopiperazine B => dimethylallyl diphosphate + preechinulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64752", "l": "3-sulfanylpentan-1-ol-L-cysteine + H2O = 3-sulfanyl-1-pentanol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250217", "l": "ARL2:GTP binds ARL2BP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0050735", "l": "N-malonyltransferase activity", "d": ["Catalysis of the transfer of a malonyl group to a nitrogen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1183003", "l": "Expression of Leptin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102796", "l": "protocatechualdehyde:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxybenzaldehyde + O2 + H2O <=> H+ + 3,4-dihydroxybenzoate + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23414", "l": "acetate + putrescine => H2O + N-acetylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13415", "l": "AMP + dTMP + H(+) => ADP + thymidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16033", "l": "2-oxoglutarate + gibberellin A44 + O2 = CO2 + gibberellin A19 + H2O + succinate", "d": []}, {"i": "EC:1.14.11.12", "l": "\"gibberellin-44 dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783332", "l": "APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211583", "l": "Partial autophosphorylation of PAK-2 at  Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30536", "l": "biotinate sulfoxide + H(+) + NADPH => biotin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985201", "l": "ABCE1 binds RNASEL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13092", "l": "6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) <=> 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008511", "l": "sodium:potassium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65103", "l": "a 1-acylglycerol + hexadecanoyl-CoA <=> an hexadecanoyl-acylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390597", "l": "Release Of ADP From Myosin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21023", "l": "5-O-(1-carboxyvinyl)-3-phosphoshikimate <=> chorismate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183122", "l": "Factor D cleaves C3b-bound Factor B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40294", "l": "ATP + CoA + tetradecanedioate <=> AMP + diphosphate + tetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938815", "l": "RNF152 polyubiquitinates RRAGA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26492", "l": "a ketone + H(+) + H2O2 + nitrite => a secondary nitroalkane + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14696", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> a dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727908", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to PSMC6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353472", "l": "Displacement of DNA glycosylase and endonucleolytic cleavage by DNA-lyase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9611839", "l": "β3-agonists bind ADRB3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163798", "l": "Furin cleaves pro-protein Z to protein Z (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72893", "l": "acetylcholine(in) + 2 H(+)(out) => acetylcholine(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757686", "l": "SERPINA6 binds PREDL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17802", "l": "acetyl-CoA + L-phenylalanine => CoA + H(+) + N-acetyl-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10049", "l": "methanethiol + O-acetyl-L-homoserine => acetate + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444523", "l": "CXCR5 binds CXCL13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4167511", "l": "HLCS biotinylates ACACB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69782", "l": "2-oxindole-3-acetate + succinyl-CoA <=> (2-oxoindol-3-yl)acetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75149", "l": "(-)-cyatha-3,12-diene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36980", "l": "(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134962", "l": "DHX36 binds DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74725", "l": "3',4'-O-dimethylquercetin + 2 H(+) + S-adenosyl-L-homocysteine => isorhamnetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951676", "l": "RUNX3 binds TEADs and YAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818574", "l": "TASP1 cleaves KMT2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9651456", "l": "SERPING1 variant does not bind factor XIIa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676229", "l": "WIPIs bind PI3P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197690", "l": "Detachment of WASP/WAVE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71164", "l": "homogentisate + O2 => maleylacetoacetate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848818", "l": "PTK6 phosphorylates CBL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37762", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.-", "l": "\"In phosphorus-containing anhydrides\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70687", "l": "4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) = 4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002196", "l": "Ser-tRNA(Ala) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031818", "l": "P2Y9 nucleotide receptor binding", "d": ["Binding to a P2Y9 nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140475", "l": "spindle pole body anchor activity", "d": ["The binding activity of a protein that brings together the spindle pole body and one or more other molecules, permitting them to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43403", "l": "N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008692", "l": "IL37(?-218) binds SMAD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21298", "l": "D-galactono-1,4-lactone + H(+) + NADH => D-galactose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19026", "l": "H2O + L-aspartate + O2 => H2O2 + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944632", "l": "miR-106 microRNAs bind PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21671", "l": "ATP + H2O + sn-glycerol 3-phosphate(out) <=> ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15412", "l": "1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine <=> 1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68826", "l": "(Z)-beta-ocimene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033402", "l": "UUC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UUC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47489", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69783", "l": "(2-aminophenyl)succinate + succinyl-CoA = 2-(2-aminophenyl)succinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604752", "l": "Initial activation of proMMP13 by MMP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66670", "l": "4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50452", "l": "prostaglandin H3 = prostaglandin E3", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033873", "l": "petromyzonol sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol = 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75693", "l": "2'-deoxyadenosine(out) => 2'-deoxyadenosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72390", "l": "2 hydrogencarbonate(out) + sulfate(in) <=> 2 hydrogencarbonate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.316", "l": "\"mitomycin 6-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56214", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP => O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684096", "l": "CDK2 phosphorylates RBBP8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40286", "l": "(R)-carnitine + hexadecanedioyl-CoA <=> CoA + O-hexadecanedioyl-L-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59117", "l": "[protein]-dithiol + O2 => [protein]-disulfide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381612", "l": "GLP1R binds GLP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55890", "l": "[excited state blue fluorescent protein] + CO2 => [aequorin]--dioxetanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667638", "l": "NBEA translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853801", "l": "PSPN binds RET:GFRA4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69298", "l": "3-hydroxypent-4-ene nitrile + sulfate + sulfur => (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018712", "l": "3-hydroxybutyryl-CoA thiolase activity", "d": ["Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72185", "l": "creatinine(out) + H(+)(in) => creatinine(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0035091", "l": "phosphatidylinositol binding", "d": ["Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371422", "l": "ATP hydrolysis by HSP70 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202453", "l": "Auto-ubiquitination of TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64675", "l": "2-(methylsulfanyl)acetyl-CoA + butan-1-ol <=> butyl 2-(methylsulfanyl)acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14909", "l": "L-gulonate + NADP(+) = aldehydo-D-glucuronate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.19", "l": "\"glucuronate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17971", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine => ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74885", "l": "GUCYs converts GTP to cGMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21918", "l": "an aldehyde + 2 Fe(II)-[cytochrome c550] + 2 H(+) + NH4(+) => an aliphatic amine + 2 Fe(III)-[cytochrome c550] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.93", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202724", "l": "P-selectin binds P-selectin ligand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53149", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019194", "l": "sorbose transmembrane transporter activity", "d": ["Enables the transfer of sorbose from one side of a membrane to the other. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937814", "l": "RUNX3 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12442", "l": "2-oxoglutarate + H(+) + L-lysine + NADH => H2O + L-saccharopine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73596", "l": "CTP(out) + dUMP(in) => CTP(in) + dUMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63920", "l": "octadecanoyl-CoA + sphinga-4E,14Z-dienine = CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749494", "l": "IKBIP binds IKBKB and CHUK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18515", "l": "D-mannose + H2O2 => D-mannitol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63359", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2 <=> (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22741", "l": "ATP + D-hexose => ADP + D-hexose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50772", "l": "H2O + nitroethane + O2 = acetaldehyde + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856157", "l": "LAG3 (CD233) binds MHC II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15022", "l": "(E)-feruloyl-CoA + L-quinate => 4-O-feruloyl-D-quinate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.59", "l": "\"mitochondrial intermediate peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67067", "l": "AH2 + asnovolin K <=> A + asnovolin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5668735", "l": "RAC1:GTP binds NOX3 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39784", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34070", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate <=> diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807585", "l": "BPI binds LPS on the bacterial surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216282", "l": "Ubiquitinated CI is degraded by the proteasome complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56279", "l": "ATP + L-proline <=> 3'-L-prolyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22185", "l": "(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) => acenaphthene-1,2-dione + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34022", "l": "a 1-acylglycerol + H2O <=> a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39251", "l": "(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH = (11Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0016215", "l": "acyl-CoA desaturase activity", "d": ["Catalysis of the reaction: AH2 + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + A + 2 H2O."]}, {"i": "RHEA:25416", "l": "AH2 + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16497", "l": "adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.181", "l": "\"23S rRNA (adenine(1618)-N(6))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853444", "l": "AURKA phosphorylates PHLDA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60121", "l": "(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine => H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75887", "l": "ADP-1-deoxy-1,O(4)-didehydro-D-ribose + L-arginyl-[protein] = ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41759", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 <=> 1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17125", "l": "H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine = 2-oxoglutarate + N-(2-aminobutanoyl)glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848586", "l": "Transport of cytosolic HXOL to the peroxisome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58655", "l": "rifamycin SV ortho-naphthoquinone carboxamide <=> rifamycin SV para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26560", "l": "(2E)-butenoyl-CoA + H2O => (3S)-3-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75936", "l": "ATP + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine => 6-O-phospho-N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804425", "l": "TP53 binds POU4F2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40371", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP = 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.181", "l": "\"polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160874", "l": "HYAL1 hydrolyses (HA)50 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050352", "l": "trimethylamine-oxide aldolase activity", "d": ["Catalysis of the reaction: H+ + trimethylamine N-oxide = dimethylamine + formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11166", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195304", "l": "Association of beta-catenin with the destruction complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202291", "l": "Activation of Lck (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42910", "l": "5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(1939) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102326", "l": "2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate + H2O <=> 2,3-dihydroxybenzoate + 2-oxopent-4-enoate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.5", "l": "\"aldehyde dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36286", "l": "1,7-dimethylxanthine + H(+) + NADPH + O2 <=> 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55994", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.41", "l": "\"3-hydroxy-D-aspartate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019909", "l": "[pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity", "d": ["Binds to and modulates of the activity of [pyruvate dehydrogenase (lipoamide)] phosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18927", "l": "D-glucurono-3,6-lactone + H(+) + NADPH => L-gulono-1,4-lactone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018758", "l": "2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity", "d": ["Catalysis of the reaction: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine + H2O = CH3CH2NH2 + cyanuric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20287", "l": "alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660824", "l": "ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130504", "l": "Cleavage of lip22 to lip10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102899", "l": "dehydroabietadienol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + dehydroabietadienol + NADPH + O2 <=> dehydroabietadiene-diol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76023", "l": "18-hydroxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-oxocortisol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34673", "l": "3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39200", "l": "(3R)-hydroxytetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70888", "l": "L-glutamine(in) + L-serine(out) + Na(+)(out) => L-glutamine(out) + L-serine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019179", "l": "dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity", "d": ["Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51527", "l": "(S)-corytuberine + S-adenosyl-L-methionine <=> magnoflorine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015544", "l": "phenyl propionate uniporter activity", "d": ["Enables the transfer of phenyl propionate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14770", "l": "(S)-nicotine + A + H2O => (S)-6-hydroxynicotine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805479", "l": "TP53RK phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68090", "l": "a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase] => a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357828", "l": "RIPK1 is cleaved by CASP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9010815", "l": "SLITs bind keratan sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9035227", "l": "TXN2 binds CysS248-MPST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25472", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-himachalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376419", "l": "Formation of NR-MED1 Coactivator Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16872", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54618", "l": "2-hydroxyheptadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + heptadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72212", "l": "(+)-isoborneol + NAD(+) => (1S,4S)-camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11807", "l": "an aromatic aldehyde + H2O + NAD(+) <=> an aromatic carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14107", "l": "1-pyrroline-5-carboxylate + 2 H(+) + NADH => L-proline + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622831", "l": "Substrate:LAMP2a binds HSP90 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1218824", "l": "HSP90 is inactivated by binding to benzaquinoid ansamycins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2106615", "l": "Removal of siRNA passenger strand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174255", "l": "Degradation multiubiquitinated Cyclin A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44239", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44578", "l": "2-all-trans-nonaprenylphenol + CO2 => 4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49293", "l": "D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] => 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47660", "l": "acetyl-CoA + L-methionine sulfoximine = CoA + H(+) + N-acetyl-L-methionine sulfoximine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37813", "l": "1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29878", "l": "H2O + sn-glycero-3-phospho-L-serine <=> H(+) + L-serine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.2", "l": "\"acid phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034278", "l": "stemar-13-ene synthase activity", "d": ["Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemar-13-ene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61592", "l": "H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine = 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine", "d": []}, {"i": "EC:1.8.98.7", "l": "\"cysteine-type anaerobic sulfatase-maturating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73780", "l": "dimethylallyl diphosphate + preechinulin => diphosphate + tardioxopiperazine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45814", "l": "a very-long-chain (2E)-enoyl-CoA + H2O => a very-long-chain (3R)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28230", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.150", "l": "\"costunolide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660662", "l": "ASC binds Caspase-8 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16255", "l": "H(+) + NADH + phenanthrene-3,4-diol => (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193722", "l": "TetraHCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50346", "l": "3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+) => 3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28673", "l": "2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate => 2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.1", "l": "\"hexokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28239", "l": "calycosin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010231", "l": "ROBO1 binds FLRT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.14", "l": "\"oleoyl-[acyl-carrier-protein] hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159868", "l": "Furin cleaves pro-factor VII to factor VII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56837", "l": "[PQQ precursor protein] + S-adenosyl-L-methionine => 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51659", "l": "keto-D-tagaturonate <=> keto-D-fructuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357479", "l": "p-AXL binds PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44894", "l": "an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP => an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987223", "l": "IL10RB binds TYK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032140", "l": "single adenine insertion binding", "d": ["Binding to a double-stranded DNA region containing a single adenine insertion or a deletion that results in an unpaired adenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8987214", "l": "p-STAT3 dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450422", "l": "KSRP recruits RNA degradation activities (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806613", "l": "Keratin tetramers bind to form unit length filaments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797554", "l": "ABP1 binds SHANK proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42604", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018674", "l": "(S)-limonene 3-monooxygenase activity", "d": ["Catalysis of the reaction: (4S)-limonene + H+ + NADPH + O2 = (1S,6R)-isopiperitenol + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674140", "l": "PAQR3 binds inactive RAFs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72759", "l": "anthocyanin A6 + malonyl-CoA = anthocyanin A8 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183067", "l": "Localization of CBL:GRB2 to the membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13657", "l": "acetyl-[citrate lyase ACP] + H2O = acetate + H(+) + holo-[citrate lyase ACP]", "d": []}, {"i": "EC:3.1.2.16", "l": "\"citrate-lyase deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052720", "l": "class II DNA-(apurinic or apyrimidinic site) endonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24700", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48785", "l": "D-erythrulose 4-phosphate => D-erythrose 4-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25790", "l": "pyruvate + succinate semialdehyde => 4-hydroxy-2-oxoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63876", "l": "2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2 = (4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.75", "l": "\"3(1)-hydroxy-L-isoleucine 4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15671", "l": "a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+) => a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.36", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.42", "l": "\"flavone 3'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0003988", "l": "acetyl-CoA C-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035100", "l": "ecdysone binding", "d": ["Binding to 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31000", "l": "(S)-2,3-epoxysqualene => cucurbitadienol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27997", "l": "H2O + xanthosine <=> D-ribose + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70200", "l": "dopaminechrome => 5,6-dihydroxyindole", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034452", "l": "dynactin binding", "d": ["Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022065", "l": "DSPGs are secreted (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667809", "l": "KCNMA1:KCNMB1 transports potassium ions from the cytosol to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56159", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39971", "l": "1-aminocyclopropane-1-carboxylate = 2-aminobut-2-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76041", "l": "7-hydroxy-8-methoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.0(4,9).0(16,20)]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-cis-N-methyltetrahydrothalifendine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52777", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29361", "l": "phosphate + uridine => H2O + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61534", "l": "ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20194", "l": "(R)-mevalonate + NADP(+) => H(+) + mevaldate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31161", "l": "3-oxohexadecanoyl-CoA + H(+) + NADH => (3S)-hydroxyhexadecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.147", "l": "\"thioglucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102987", "l": "palmitoleic acid delta 12 desaturase activity", "d": ["Catalysis of the reaction: palmitoleoyl-CoA + O2 + a reduced electron acceptor <=> (9Z,12Z)-hexadecadienoyl-CoA + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664871", "l": "NBR1 translocates from cytosol to perixosomal membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102702", "l": "2-carene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate <=> (+)-2-carene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "62.258924354957735", "identifiers": [{"i": "GO:0015081", "l": "sodium ion transmembrane transporter activity", "d": ["Enables the transfer of sodium ions (Na+) from one side of a membrane to the other."]}, {"i": "RHEA:34963", "l": "Na(+)(in) = Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23677", "l": "ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15633", "l": "3,4-dihydroxyphenylacetate + O2 = 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)", "d": []}, {"i": "EC:1.13.11.15", "l": "\"3,4-dihydroxyphenylacetate 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755304", "l": "MUL1 ubiquitinates UBXN7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56318", "l": "3-acetylamino-4-hydroxybenzoate + CoA => 3-amino-4-hydroxybenzoate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17823", "l": "3-cyano-L-alanine + H(+) + hydrogen sulfide => hydrogen cyanide + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6795290", "l": "TORC2 complex phosphorylates SGK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614605", "l": "Persulfide sulfur is dioxygenated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14406", "l": "D-glucose + NADP(+) => D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26217", "l": "abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.144", "l": "\"abieta-7,13-diene hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45249", "l": "butanoate(out) => butanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71105", "l": "L-methionine(out) + S-methylmercury-L-cysteine(in) => L-methionine(in) + S-methylmercury-L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49910", "l": "(R)-carnitine(in) + O-acetyl-(R)-carnitine(out) => (R)-carnitine(out) + O-acetyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035500", "l": "MH2 domain binding", "d": ["Binding to a MH2 (MAD homology 2) protein domain. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59523", "l": "ATP + butanoyl-CoA + hydrogencarbonate <=> (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51744", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A = a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62379", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H2O <=> (S)-lactate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22184", "l": "(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) = acenaphthene-1,2-dione + 2 H(+) + 2 NADPH", "d": []}, {"i": "EC:1.10.1.1", "l": "\"trans-acenaphthene-1,2-diol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0003691", "l": "double-stranded telomeric DNA binding", "d": ["Binding to double-stranded telomere-associated DNA."]}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0010340", "l": "carboxyl-O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175993", "l": "HNMT transfers CH3 group from AdoMet to Hist (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68453", "l": "all-trans-10'-apo-beta-carotenal + O2 => 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106166", "l": "spindle pole body-nuclear membrane anchor activity", "d": ["The binding activity of a molecule that brings together a mitotic spindle pole body and the nuclear membrane, in order to maintain specific membrane location of the spindle pole body."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24340", "l": "(R,R)-butane-2,3-diol + NAD(+) = (R)-acetoin + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.4", "l": "\"(R,R)-butanediol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.21", "l": "\"glycerol-1-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41420", "l": "2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 = CO2 + grixazone B + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4395231", "l": "E2F1/3:DP1/2 binds NOTCH1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-167427", "l": "Opioid dissociates from MOR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29506", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + patchoulol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72395", "l": "2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) + K(+)(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73927", "l": "griseophenone D + S-adenosyl-L-methionine = griseophenone C + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34089", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester => a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74726", "l": "Dissociation of insulin from insulin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60333", "l": "L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109701", "l": "PDPK1 binds PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781953", "l": "YOD1 binds VCP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675206", "l": "PEA15 binds MAPK monomers and dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44990", "l": "CoA + O-isobutanoyl-(R)-carnitine => (R)-carnitine + 2-methylpropanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24061", "l": "N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.22", "l": "\"Bacillus subtilis ribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655243", "l": "Activated FGFR3 point and translocation mutants phosphorylate PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68707", "l": "3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate) <=> 3alpha-hydroxyetiocholan-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047389", "l": "glycerophosphocholine phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23872", "l": "(R)-propane-1,2-diol + NAD(+) = (R)-lactaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68358", "l": "L-glutamate + N-acetyl-L-aspartate => H2O + N-acetyl-L-aspartyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14008", "l": "H2O + L,L-cystathionine <=> 2-oxobutanoate + L-cysteine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17594", "l": "3-phenylpyruvate + L-glutamine => 2-oxoglutaramate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19295", "l": "ADP + H(+) + monoacyl-sn-glycero-3-phosphate => a monoacylglycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-448963", "l": "Interaction of MyoD:E protein with MEF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15577", "l": "H2O + uridine = D-ribose + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12759", "l": "H(+) + NADPH + zeatin => dihydrozeatin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190682", "l": "Connexin synthesis (generic) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446391", "l": "Formation of the PINCH-ILK-parvin complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0052705", "l": "methylhistidine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha-methyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha-dimethyl-L-histidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983150", "l": "Proteasomal cleavage of substrate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39159", "l": "(3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74916", "l": "a (2E)-enoyl fatty acid + ATP + H(+) => a (2E)-2-fatty-enoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6802973", "l": "PLK3 phosphorylates CDC25C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54551", "l": "D-xylulose 1,5-bisphosphate + H2O <=> D-xylulose 5-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52645", "l": "D-xylono-1,4-lactone 5-phosphate + H2O => 5-phospho-D-xylonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41401", "l": "1-hexanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433488", "l": "Phosphorylation of SHP2 by SFKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67397", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + O2 + reduced [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.89", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14116", "l": "a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O <=> a 3'-end 2'-deoxyribonucleotide-DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27348", "l": "FMNH2 + O2 <=> 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161282", "l": "Elastic fibres bind associated proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16509", "l": "H(+) + oxalate = CO2 + formate", "d": []}, {"i": "EC:4.1.1.2", "l": "\"oxalate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72714", "l": "cathenamine + H(+) <=> 4,21-dehydrogeissoschizine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11654", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592310", "l": "Aggrecan degradation by ADAMTSs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13051", "l": "D-fructuronate => D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18602", "l": "3,4-dihydroxyphthalate + H(+) => 3,4-dihydroxybenzoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193702", "l": "Part of the ICD migrates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163310", "l": "TFAM binds to mitochondrial promoters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52225", "l": "3 AH2 + 3 H(+) + heme b + 3 O2 => 3 A + biliverdin delta + CO + Fe(2+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25611", "l": "beta-D-allopyranose => beta-D-allofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981622", "l": "Myoglobin:oxygen dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29778", "l": "alpha-D-ribose 1-phosphate + ATP <=> ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16783", "l": "a fatty acid + CoA + H(+) => a fatty acyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48107", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24738", "l": "(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042016", "l": "interleukin-20 receptor activity", "d": ["Combining with interleukin-20 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183055", "l": "Binding of CBL to EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39475", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA = (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41444", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate + O2 = glycine + 2 H(+) + phosphate", "d": []}, {"i": "EC:1.13.11.78", "l": "\"2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68475", "l": "(2Z,6Z)-farnesyl diphosphate <=> (E)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25316", "l": "2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate => L-2-acetamido-6-oxoheptanedioate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8934465", "l": "SHC1 binds PTPN12 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14720", "l": "D-erythrose 4-phosphate + H2O + phosphoenolpyruvate <=> 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44500", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42431", "l": "clavaminate <=> (3R,5R)-clavulanate-9-aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113429", "l": "Elongating transcript encounters a lesion in the template (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604752", "l": "Initial activation of proMMP13 by MMP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27487", "l": "(S)-2-ureidoglycine + CO2 + NH4(+) => allantoate + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371590", "l": "HSP70 binds to HSP40:nascent protein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222641", "l": "Carboxymycobactin binds LTF:2xFe3+:2xCO3(2-) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25749", "l": "2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607721", "l": "Activation of NIK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54245", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42736", "l": "guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.172", "l": "\"16S rRNA (guanine(1207)-N(2))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5218805", "l": "PKC autophosphorylates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34481", "l": "15-cis-phytoene + diphosphate => (1R,2R,3R)-prephytoene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50351", "l": "alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] <=> a dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690023", "l": "NUBPL binds 4Fe-4S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373075", "l": "Metabotropic glutamate receptors bind glutamate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388605", "l": "POMC(138-176) binds MC2R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031803", "l": "type 6 metabotropic glutamate receptor binding", "d": ["Binding to a type 6 metabotropic glutamate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236963", "l": "Maturation of phagosome into phagolysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865605", "l": "BRWD1 binds SMARCA4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24288", "l": "5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine", "d": []}, {"i": "EC:2.1.2.4", "l": "\"glycine formimidoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27956", "l": "diphosphate + presilphiperfolan-8beta-ol => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60467", "l": "2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.96.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20596", "l": "H2O + N-acetyl-D-glucosamine <=> acetate + D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45537", "l": "H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350158", "l": "LGMN degrades GC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66776", "l": "ATP + H2O + uroporphyrin III(in) = ADP + H(+) + phosphate + uroporphyrin III(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37956", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9663511", "l": "BIL binds GSTA1, FABP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56760", "l": "24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72451", "l": "a dicarboxylate(in) + dehydroepiandrosterone 3-sulfate(out) = a dicarboxylate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112510", "l": "IL6ST is tyrosine phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30732", "l": "butanoyl-CoA + FAD + H(+) => (2E)-butenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1964496", "l": "STING binds TRIM32 or TRIM56  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56393", "l": "[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54790", "l": "[LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => [LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3341294", "l": "Superoxide reduces cytochrome c (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34115", "l": "carboxynorspermidine + H2O + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13012", "l": "H2O + N-formyl-L-kynurenine <=> formate + H(+) + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68173", "l": "2-oxoglutarate + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + O2 => CO2 + H2O + isodomoate A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57523", "l": "15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63026", "l": "(13Z)-docosenoate + NH4(+) => (13Z)-docosenamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44836", "l": "globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose = globoside NOR2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046526", "l": "D-xylulose reductase activity", "d": ["Catalysis of the reaction: NAD+ + xylitol = D-xylulose + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30199", "l": "2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate = 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32522", "l": "(2E)-geranyl diphosphate + S-adenosyl-L-methionine <=> (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237160", "l": "MTA is cleaved and phosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857555", "l": "EGFR phosphorylates GPNMB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015210", "l": "uracil transmembrane transporter activity", "d": ["Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23319", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 <=> 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701064", "l": "TRPV1 binds TRPV1 agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42522", "l": "pseudouridine(2605) in 23S rRNA => uridine(2605) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621002", "l": "HOXB1 activates HOXB2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55869", "l": "(S)-lactate + O2 => H2O2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043770", "l": "demethylmenaquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-demethylmenaquinone + S-adenosyl-L-methionine = menaquinone + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40463", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34620", "l": "1-deoxypentalenate + 2-oxoglutarate + O2 => 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769383", "l": "CBY1 binds beta-catenin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3781941", "l": "WNTs are secreted in exosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015421", "l": "ABC-type oligopeptide transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110219", "l": "Cleavage of thymine by TDG glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.66", "l": "\"calicivirin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948775", "l": "MKRN1 polyubiquitinates PTEN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53888", "l": "D-glucose 6-phosphate + TDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + TDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9626928", "l": "CREBBP binds FOXO1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374173", "l": "AGT(34-41) binds to AGTR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49424", "l": "ATP + validone = ADP + H(+) + validone 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.21", "l": "\"aldose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44840", "l": "(R)-carnitine + octadecanoyl-CoA = CoA + O-octadecanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63079", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 2-acetylphloroglucinol + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012835", "l": "GDIs block activation of RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102661", "l": "homogentisate solanyltransferase activity", "d": ["Catalysis of the reaction: all-trans-nonaprenyl diphosphate + homogentisate + H+ <=> 2-methyl-6-all-trans-nonaprenyl-1,4-benzoquinone + carbon dioxide + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870465", "l": "RGGT binds the RAB-binding subunit (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209158", "l": "Polymeric PGN bound PGRP-LCx multimerises at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9008043", "l": "MAPK8 phosphorylation (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70940", "l": "L-methionine(in) => L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.72", "l": "\"branched-chain-2-oxoacid decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38789", "l": "(9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015361", "l": "low-affinity sodium:dicarboxylate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}, {"i": "REACT:R-HSA-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39662", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59985", "l": "an N(2)-acyl-L-glutamine + H2O => a carboxylate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070653", "l": "high-density lipoprotein particle receptor binding", "d": ["Binding to a high-density lipoprotein receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690152", "l": "USP5 cleaves polyubiquitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.6", "l": "\"hydroxyacylglutathione hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31917", "l": "ADP + alpha-maltose 1-phosphate + H(+) => ATP + D-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74938", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2 2-oxoglutarate + 2 O2 <=> (3R)-3-isocyanylbutanoate + 3 CO2 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36617", "l": "CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine => 2-hydroxyoctadecanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166223", "l": "The proton is delivered to the matrix side (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38248", "l": "(9Z)-hexadecenoyl-CoA + hexadecan-1-ol => 1-O-hexadecyl (9Z)-hexadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40424", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938913", "l": "RUNX1 binds ELF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-481009", "l": "Exocytosis of platelet dense granule content (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55587", "l": "an adenosine in mRNA + S-adenosyl-L-methionine <=> an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687465", "l": "MRN complex binds RBBP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043808", "l": "lyso-ornithine lipid acyltransferase activity", "d": ["Catalysis of the reaction: lyso-ornithine lipid + acyl-[acyl-carrier protein] = ornithine lipid + [acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73494", "l": "Co(2+)(out) + 2 hydrogencarbonate(out) <=> Co(2+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38997", "l": "a 1-acyl-sn-glycero-3-phosphate + choline + H(+) => a 1-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-165195", "l": "GTP loading by Rheb (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9821931", "l": "BOD1L1 binds SET1A complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791164", "l": "Expression of SSR1 (Trap alpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427337", "l": "MBD2 binds methylcytosine in chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73630", "l": "CTP(out) + GMP(in) <=> CTP(in) + GMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50248", "l": "ATP + D-ribose 5-phosphate + H(+) = ADP-D-ribose + diphosphate", "d": []}, {"i": "EC:2.7.7.96", "l": "\"ADP-D-ribose pyrophosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18742", "l": "10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA => 10-deacetylbaccatin III + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0030332", "l": "cyclin binding", "d": ["Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40862", "l": "(9Z)-hexadecenoyl-CoA + FAD + H(+) <=> (2E,9Z)-hexadecadienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209792", "l": "N-acetylation of serotonin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68788", "l": "(2Z,6Z)-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140868", "l": "4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming)", "d": ["Catalysis of the reaction: 3 H+ + 15-cis-4,4'-diapophytoene + 4 FAD = 4,4'-diapolycopene + 3 FADH2. This reaction consists of three successive dehydrogenations that lead to the introduction of three double bonds into 4,4'-diapophytoene (dehydrosqualene), with 4,4'-diapophytofluene and 4,4'-diapo-zeta-carotene as intermediates, and 4,4'-diaponeurosporene (the major deep-yellow pigment in staphylococci strains) as the end product."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22952", "l": "O2 + octanedioyl-CoA = (2E)-octenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72389", "l": "2 hydrogencarbonate(in) + sulfate(out) => 2 hydrogencarbonate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0043531", "l": "ADP binding", "d": ["Binding to ADP, adenosine 5'-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182990", "l": "Sprouty sequesters CBL away from active EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32888", "l": "all-trans-beta-carotene + O2 => 2 all-trans-retinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72500", "l": "2-oxoglutarate(in) + prostaglandin E2(out) => 2-oxoglutarate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15764", "l": "L-homoserine + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50140", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432897", "l": "ILK interacts with beta-1 integrin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48901", "l": "chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] => 3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74609", "l": "UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-galactosamine(in) => UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-galactosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047498", "l": "calcium-dependent phospholipase A2 activity", "d": ["Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+."]}, {"i": "REACT:R-HSA-111883", "l": "Hydrolysis of phosphatidylcholine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0005184", "l": "neuropeptide hormone activity", "d": ["The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2172666", "l": "RB1 binds condensin II (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56216", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050638", "l": "taxadien-5-alpha-ol O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678981", "l": "TLR9 processing at neutral pH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102528", "l": "7,8,4'-trihydroxyflavone methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 7,8,4'-trihydroxyflavone <=> H+ + S-adenosyl-L-homocysteine + 7,4'-dihydroxy, 8-methoxyflavone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685319", "l": "CX3 complex formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61423", "l": "(S)-8-oxocitronellyl enol <=> cis-cis-nepetalactol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71816", "l": "3,3',5'-triiodo-L-thyronine(out) => 3,3',5'-triiodo-L-thyronine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399931", "l": "Activation of Fyn (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443779", "l": "Linkage of L1 with treadmilling F-actin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9688838", "l": "RIPK3 binds STUB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52764", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O = (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37298", "l": "ATP + H2O + L-alanyl-L-threonine(out) <=> ADP + H(+) + L-alanyl-L-threonine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55853", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668605", "l": "RAC2:GTP binds NOX2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53272", "l": "5-dehydro-L-gluconate = keto-D-tagaturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62861", "l": "acetyl-CoA + 7 H(+) + 7 malonyl-CoA => 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72657", "l": "1-hydroxy-6-methoxyphenazine N(10)-oxide + H2O + NADP(+) => 1-hydroxy-6-methoxyphenazine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.14", "l": "\"actinidain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69495", "l": "O2 + octan-1-ol <=> H2O2 + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52706", "l": "D-ribose 5-phosphate + uracil => H2O + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3785684", "l": "Fibronectin degradation by CTSG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.134", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140761", "l": "sequestered tissue factor -> tissue factor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57886", "l": "H(+) + Na(+)(out) + 2 phosphate => diphosphate + H2O + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37448", "l": "O2 + tetracenomycin F1 => H(+) + H2O + tetracenomycin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168317", "l": "Recruitment of Karyopherin Beta to form a Trimeric Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68960", "l": "DNA polymerase epsilon binds at the origin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22924", "l": "dCMP + H(+) + H2O = dUMP + NH4(+)", "d": []}, {"i": "EC:3.5.4.12", "l": "\"dCMP deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.91", "l": "\"tRNA-dihydrouridine(20) synthase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47600", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate = CMP + ganglioside GM4 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045237", "l": "CXCR1 chemokine receptor binding", "d": ["Binding to a CXCR1 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2574845", "l": "AJUBA binds centrosome-associated AURKA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22728", "l": "H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate", "d": []}, {"i": "EC:2.9.1.1", "l": "\"L-seryl-tRNA(Sec) selenium transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.46", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24977", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694333", "l": "3CLp forms a homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32957", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68253", "l": "L-tryptophan(in) + Na(+)(in) => L-tryptophan(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55654", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59194", "l": "diphosphate + icosanoyl-AMP => ATP + eicosanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004493", "l": "methylmalonyl-CoA epimerase activity", "d": ["Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44428", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol = a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944026", "l": "SNAI1,SNAI2 bind the PTEN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51804", "l": "deoxyhumulone + dimethylallyl diphosphate = diphosphate + H(+) + lupulone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69001", "l": "3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine => 3-amino-2-hydroxy-4-methoxybenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51613", "l": "(R)-2-hydroxyglutarate + oxaloacetate => (R)-malate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034076", "l": "cucurbitadienol synthase activity", "d": ["Catalysis of the reaction: oxidosqualene = cucurbitadienol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623366", "l": "NR1H2,3 binds the MYLIP gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43497", "l": "L-gulonate + NAD(+) => H(+) + keto-D-fructuronate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31539", "l": "(2S)-naringenin + S-adenosyl-L-methionine = (2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.232", "l": "\"naringenin 7-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62725", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) => (+)-isomalbrancheamide C + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43825", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379387", "l": "COMT transfers Met to DA to form 3MT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617595", "l": "SGTA binds mislocalized membrane protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209973", "l": "Tyrosine is diiodinated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008667", "l": "2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity", "d": ["Catalysis of the reaction: (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD+ = 2,3-dihydroxybenzoate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30189", "l": "a quinol + orotate => (S)-dihydroorotate + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213201", "l": "Formation of collagen fibres (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191072", "l": "Synthesis of Cx43 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955844", "l": "RBKS phosphorylates ribose to R5P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-378952", "l": "Thyrotropin is a heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77081", "l": "Formation of the CE:GMP intermediate complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9794523", "l": "SLC22A1 transports Cipro into renal cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66712", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70579", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64859", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + phomopsene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64346", "l": "2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+) => 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173626", "l": "Activation of C1r (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68167", "l": "N-(8'-hydroxygeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + N-(8'-oxogeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10153", "l": "ATP + hydrogencarbonate + NH4(+) => ADP + carbamoyl phosphate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26262", "l": "H2O + isopimara-7,15-dienal + NADP(+) => 2 H(+) + isopimarate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29851", "l": "H2O + UDP-N-acetyl-alpha-D-galactosamine = 2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679029", "l": "C-ter TLR7 dimer binds HCQ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57126", "l": "2-hydroxy-5-oxoproline => 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617583", "l": "CaMKII autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17654", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050360", "l": "tryptophan 2'-dioxygenase activity", "d": ["Catalysis of the reaction: L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877281", "l": "PIAS1 binds p-STAT1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981355", "l": "RASA1 binds RAS:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237160", "l": "MTA is cleaved and phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53516", "l": "1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047876", "l": "endoglycosylceramidase activity", "d": ["Catalysis of the reaction: H2O + oligoglycosylglucosylceramide = ceramide + oligoglycosylglucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77589", "l": "Recognition of AAUAAA sequence by CPSF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191784", "l": "snRNA Cap hypermethylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2990882", "l": "CDK1 phosphorylates NUP98 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046970", "l": "NAD-dependent histone H4K16 deacetylase activity", "d": ["Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229181", "l": "CALM1:Ca2+ binds CNG channel (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30204", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate => 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20390", "l": "(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 => (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13818", "l": "[protein]-disulfide + H2O + phylloquinone => 2,3-epoxyphylloquinone + [protein]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60698", "l": "(R)-lavandulol + diphosphate => (R)-lavandulyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75087", "l": "32-hydroxy-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 32-oxo-24,25-dihydrolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40957", "l": "ADP + CO2 + isopentenyl phosphate + phosphate => (R)-5-phosphomevalonate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001057", "l": "RNA polymerase IV activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase IV specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35167", "l": "minocycline(in) = minocycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53253", "l": "lathosterol + O2 + reduced [NADPH--hemoprotein reductase] => 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12298", "l": "dopamine + secologanin => deacetylipecoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64395", "l": "a dipeptide(out) + H(+)(out) <=> a dipeptide(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25419", "l": "AH2 + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49165", "l": "a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2152276", "l": "Secretion of transmembrane collagens (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55028", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine = an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783670", "l": "CRLF1 binds CLCF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61386", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17302", "l": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] => ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62208", "l": "3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] = 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017065", "l": "single-strand selective uracil DNA N-glycosylase activity", "d": ["Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA."]}, {"i": "REACT:R-HSA-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65109", "l": "aculene C + L-prolyl-[peptidyl-carrier protein] => aculene A + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33656", "l": "(9Z)-octadecenoate(out) => (9Z)-octadecenoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67398", "l": "5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445069", "l": "L1-EGFR trans-heterodimerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018804", "l": "RAC3 GEFs activate RAC3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.142", "l": "\"glycoprotein O-fatty-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033401", "l": "UUU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UUU codon."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018554", "l": "1,2-dihydroxynaphthalene dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxynaphthalene + O2 = 2-hydroxychromene-2-carboxylate. C6 of the substrate molecular may have an NH2 group attached."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28182", "l": "(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate = (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate", "d": []}, {"i": "EC:5.3.3.17", "l": "\"trans-2,3-dihydro-3-hydroxyanthranilate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32575", "l": "(2E)-geranyl diphosphate = (1R,5R)-alpha-pinene + diphosphate", "d": []}, {"i": "EC:4.2.3.121", "l": "\"(+)-alpha-pinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51557", "l": "(S)-glaucine + S-adenosyl-L-methionine => (S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444202", "l": "Receptor FFAR1 binds free fatty acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71721", "l": "H(+)(in) + L-methionyl-L-phenylalanyl-L-methionine(in) => H(+)(out) + L-methionyl-L-phenylalanyl-L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015520", "l": "tetracycline:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229283", "l": "LCNs bind lipids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56905", "l": "an acyl-AMP + CoA => AMP + an acyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67227", "l": "(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17034", "l": "(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) => biphenyl-2,3-diol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39029", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0061604", "l": "molybdopterin-synthase sulfurtransferase activity", "d": ["Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine = AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0023029", "l": "MHC class Ib protein binding", "d": ["Binding to a major histocompatibility complex class Ib molecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11239", "l": "putrescine + spermidine <=> propane-1,3-diamine + sym-homospermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19010", "l": "a 3-acylpyruvate + H2O => a carboxylate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62617", "l": "a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose => a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65152", "l": "(2S)-naringenin + UDP-alpha-D-glucose = (2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9660557", "l": "RAS:GTP binds RAL GDS proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871265", "l": "YAP1 binds TEAD4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451311", "l": "Activation of Ca-permeable Kainate receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447226", "l": "Interleukin-12 binds Interleukin-12 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24957", "l": "H2O + N-acetyl-beta-D-muramate 6-phosphate => (R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9731931", "l": "EDNRA binds selective ERAs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618107", "l": "ATP binding to HSP90 triggers conformation change (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140871", "l": "repressor of RNA polymerase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of an RNA polymerase inhibitor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866858", "l": "CFTR F508del is degraded by the 26S proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810076", "l": "DDO oxidizes D-Asp to OA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874186", "l": "MBTPS1 (S1P) cleaves CREB3L4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56192", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66203", "l": "O2 + pentanoyl-CoA <=> (2E)-pentenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033942", "l": "4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity", "d": ["Catalysis of the hydrolysis of alpha-(1->4)-D-glucosidic linkage in 4-alpha-D-{(1->4)-alpha-D-glucanosyl}n trehalose to yield trehalose and alpha-(1->4)-D-glucan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67449", "l": "(2R)-2-hydroxyoctadecanoyl-CoA => formyl-CoA + heptadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35041", "l": "spermidine(out) => spermidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008758", "l": "UDP-2,3-diacylglucosamine hydrolase activity", "d": ["Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60082", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+) => 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009085", "l": "DEXA:NR3C1 complex binds RUNX2 gene proximal promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46486", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26271", "l": "Co(2+) + precorrin-2 => Co-precorrin-2 + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50599", "l": "acetyl-CoA + N-terminal L-seryl-[histone H4] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18217", "l": "2-oxoglutarate + an alkane-alpha,omega-diamine = an omega-aminoaldehyde + L-glutamate", "d": []}, {"i": "EC:2.6.1.29", "l": "\"diamine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53859", "l": "NADP(+) + ursocholate <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51694", "l": "3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O => prephenate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951676", "l": "RUNX3 binds TEADs and YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202692", "l": "PIP3 binds to RhoA and activates it (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168412", "l": "MDP elicits a NOD2 response (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67239", "l": "mycophenolyl-CoA + propanoyl-CoA <=> (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69938", "l": "guanosine(out) + Na(+)(out) <=> guanosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70603", "l": "4-hydroxystyrene + H(+) + NADH = 4-ethylphenol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43061", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate => beta-D-glucose 1-phosphate + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56243", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700154", "l": "Active ALK binds SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16750", "l": "H2O + phosphonoacetate => acetate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32687", "l": "(2E)-geranyl diphosphate = diphosphate + tricyclene", "d": []}, {"i": "EC:4.2.3.105", "l": "\"tricyclene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654515", "l": "KAL1 binds HS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34204", "l": "2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 => aureusidin 6-O-beta-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32506", "l": "linalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53869", "l": "2 H(+) + NADH + O2 + phenazine-1-carboxylate => 1-hydroxyphenazine + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51828", "l": "ATP(in) + CoA(in) + docosanoate(out) + H(+)(out) = AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67843", "l": "a lipid A disaccharide + ATP <=> a lipid IVA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696947", "l": "USP47 deubiquitinates POLB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58179", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH <=> all-trans-lycopaoctaene + 2 diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204861", "l": "Interaction of Tie2 and Shc1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1912379", "l": "Transport of fringe-modified NOTCH to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.6", "l": "\"leucine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60340", "l": "N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102845", "l": "1-18:3-2-16:0-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62616", "l": "a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose = a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23071", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA <=> 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17446", "l": "H2 + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39026", "l": "an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27443", "l": "D-xylose + H(+) + NADH => NAD(+) + xylitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877620", "l": "ECE2 cleaves EDN1(53-90) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1977959", "l": "ERBB4 forms heterodimers with EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174963", "l": "NAT1 acetylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74986", "l": "Elongation of pre-rRNA transcript (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58629", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV => FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20095", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP => an anthocyanidin + H(+) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106328", "l": "acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42435", "l": "3-hydroxy-cis,cis-muconate <=> maleylacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65250", "l": "6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O => AH2 + 5 H(+) + 5 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035446", "l": "cysteine-glucosaminylinositol ligase activity", "d": ["Catalysis of the reaction: 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + L-cysteine + ATP = 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + 2 H+. 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol is also known as glucosaminyl-inositol or GlcN-Ins, and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as desacetylmycothiol or Cys-GlcN-Ins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34814", "l": "NADP(+) + tetrahydrocurcumin <=> dihydrocurcumin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696947", "l": "USP47 deubiquitinates POLB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16535", "l": "H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP => L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75792", "l": "(S)-lactate(out) + Na(+)(out) => (S)-lactate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9620103", "l": "ALDH2 transforms GTN to NO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655702", "l": "Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213244", "l": "Loading of antigenic peptides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58337", "l": "a 4-hydroxynonen-1-ol + NADP(+) => a 4-hydroxynonenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18071", "l": "D-arginine => L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103078", "l": "quercetin 3-rhamnoside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: H+ + quercetin 3-O-rhamnoside + UDP-L-rhamnose <=> quercetin-3-rhamnoside-7-rhamnoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60042", "l": "(2E)-3-methylhex-2-enoate + L-glutamine => H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69190", "l": "ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[protein] + phosphate => ATP + gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37547", "l": "D-glucose 6-phosphate + NAD(+) = 3-dehydro-D-glucose 6-phosphate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.361", "l": "\"glucose-6-phosphate 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72963", "l": "acetoacetate(out) + 2 Na(+)(out) = acetoacetate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004127", "l": "cytidylate kinase activity", "d": ["Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37188", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate => 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9726509", "l": "NR3C2 binds fludrocortisone (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60162", "l": "ADP + H(+) + phosphate + vincristine(out) => ATP + H2O + vincristine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419003", "l": "Interaction of Nectins with Afadin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11562", "l": "catechol + CO2 + NADH => (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10004", "l": "benzyl isothiocyanate = benzyl thiocyanate", "d": []}, {"i": "EC:5.99.1.1", "l": "\"thiocyanate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944262", "l": "Association of procollagen type X (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70067", "l": "a C29-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a (22S)-22-hydroxy C29-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187382", "l": "Degradation of ubiquitinated SMAD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12852", "l": "H2O + O-phospho-L-seryl-[myosin light chain] <=> L-seryl-[myosin light chain] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43046", "l": "CoA + H(+) + N-octadecanoylhexadecasphinganine => hexadecasphinganine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0070336", "l": "flap-structured DNA binding", "d": ["Binding to a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641206", "l": "RSPOs bind LGRs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12315", "l": "dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 <=> 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11768", "l": "diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate", "d": []}, {"i": "EC:2.4.2.18", "l": "\"anthranilate phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2404144", "l": "Parenchymal atROL translocates to HSCs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38258", "l": "(S)-malate + succinyl-CoA <=> (S)-malyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619467", "l": "PPM1F dephosphorylates CAMK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23491", "l": "1,4-benzoquinone + H(+) + NADPH <=> hydroquinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1028820", "l": "Formation of VAF (virus-activated factor) complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52946", "l": "choloyl-24-O-(beta-D-glucuronate) + UDP => cholate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71483", "l": "H2O + Met-enkephalin = L-phenylalanyl-L-methionine + L-tyrosylglycylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23487", "l": "A + D-cellobiose <=> AH2 + D-cellobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905761", "l": "SCF ubiquitin ligase complex binding", "d": ["Binding to a SCF ubiquitin ligase complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801089", "l": "TP53 stimulates RABGGTA expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72184", "l": "creatinine(in) + H(+)(out) => creatinine(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55248", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64398", "l": "glycyl-sarcosine(in) + H(+)(in) => glycyl-sarcosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849435", "l": "PTPN1 dephosphorylates PTK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39382", "l": "(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH <=> (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654511", "l": "FGFRL1 dimer binds FGFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52900", "l": "3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide = 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate", "d": []}, {"i": "EC:6.3.3.7", "l": "\"Ni-sirohydrochlorin a,c-diamide reductive cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114553", "l": "Activation of conventional Protein Kinase C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450387", "l": "HuR binds the CRM1 nuclear export machinery (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64267", "l": "atrochrysone carboxylate + H(+) <=> atrochrysone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32937", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+) => a cardiolipin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45728", "l": "(E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47484", "l": "deoxycholate + NAD(+) = 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24561", "l": "acetyl-CoA + L-serine => CoA + O-acetyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56768", "l": "2 AH2 + all-trans-zeaxanthin + 2 O2 = 2 A + all-trans-adonixanthin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28702", "l": "Mn(2+)(in) <=> Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70128", "l": "3-dehydro-6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydro-6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211467", "l": "HNF1A-dependent synthesis of HNF4G protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750942", "l": "USP14 deubiquitinates NLRC5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32579", "l": "(2E)-geranyl diphosphate = (1R,5R)-beta-pinene + diphosphate", "d": []}, {"i": "EC:4.2.3.122", "l": "\"(+)-beta-pinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032775", "l": "YAP1 binds TEAD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45214", "l": "CO + CoA + methyl-Co(III)-[corrinoid Fe-S protein] => acetyl-CoA + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59785", "l": "H2O + NADP(+) + pseudopaline => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63456", "l": "(2E,6E,10E)-geranylgeraniol + CTP = (2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202709", "l": "JAM2 dimerises (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389352", "l": "Translocation of Vav1 to CD28 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73732", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate => (2S,3R,11S)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20514", "l": "2-aryl-2-methylmalonate + H(+) => 2-arylpropionate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57839", "l": "H2O + O2 + thermospermine <=> 3-aminopropanal + H2O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12094", "l": "(R)-acetoin => (S)-acetoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44149", "l": "L-lysine => D-beta-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661820", "l": "Bacterial GUSB hydrolyses BDG to BIL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50401", "l": "L-cysteinyl-[PqsC protein] + octanoyl-CoA => CoA + S-octanoyl-L-cysteinyl-[PqsC protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0106359", "l": "2-hydroxyacyl-CoA lyase activity", "d": ["Catalysis of the reaction: a 2-hydroxy fatty acyl-CoA = a fatty aldehyde + formyl-CoA. The reaction acts on 2-hydroxy-3-methyl-branched fatty acyl-CoA and 2-hydroxy-long-chain fatty acyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5662466", "l": "XYLB phosphorylates D-xylulose (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627350", "l": "SMAC (DIABLO) binds XIAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864577", "l": "TFAP2C translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030790", "l": "chlorophenol O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32377", "l": "1-hydroxylimonen-2-one + H(+) + NADH => limonene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084912", "l": "Arresten binds integrin alpha1beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106222", "l": "lncRNA binding", "d": ["Binding to a long noncoding RNA (lncRNA)."]}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004645", "l": "1,4-alpha-oligoglucan phosphorylase activity", "d": ["Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374298", "l": "Opioid receptors bind opioid peptides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37932", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102455", "l": "anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + an anthocyanidin-3-O-beta-D-glucoside = UDP + H+ + an anthocyanidin 3-O-sophoroside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63729", "l": "candesartan + UDP-alpha-D-glucuronate => candesartan-2-N-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74950", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2-oxoglutarate + O2 <=> (3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26342", "l": "L-selenocysteine + S-methyl-L-methionine => H(+) + L-methionine + Se-methyl-L-selenocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59567", "l": "H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone <=> H(+) + N,N',N'',N'''-tetraacetylchitotetraonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52347", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate <=> (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707586", "l": "FeHM oxidises LDL,HDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034281", "l": "ent-isokaurene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-isokaurene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42528", "l": "uridine(955/2504/2580) in 23S rRNA = pseudouridine(955/2504/2580) in 23S rRNA", "d": []}, {"i": "EC:5.4.99.24", "l": "\"23S rRNA pseudouridine(955/2504/2580) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110218", "l": "Cleavage of uracil by TDG glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31973", "l": "10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+) => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18584", "l": "ethanolamine + H2O + O2 <=> glycolaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36952", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2 => (9Z)-heptadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794353", "l": "NRXNs binds MUNC18 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675473", "l": "SH2B binds JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39402", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA <=> (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062150", "l": "amorpha-4,11-diene 12-monooxygenase activity", "d": ["Catalysis of the reaction:(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174446", "l": "Removal of remaining Flap from the C-strand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38218", "l": "D-glucose 6-phosphate + NAD(+) <=> 6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55505", "l": "(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] => (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139899", "l": "Sequestration of BAD protein by 14-3-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252072", "l": "AZGP1 binds PIP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35790", "l": "paromamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin C + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13781", "l": "an L-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+)", "d": []}, {"i": "EC:1.4.3.2", "l": "\"L-amino-acid oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74337", "l": "O-2-methylbutanoyl-(R)-carnitine(out) => O-2-methylbutanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34921", "l": "thiamine(out) => thiamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12800", "l": "(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + scopolamine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27950", "l": "L-phenylalanine(in) = L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69152", "l": "spermine monoaldehyde = acrolein + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55180", "l": "2-oxoglutarate + 3-methylnonanoyl-CoA + O2 = 2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43576", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43697", "l": "H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate => diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64371", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12256", "l": "L-arogenate + NAD(+) = CO2 + L-tyrosine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21749", "l": "(S)-lactaldehyde + NADP(+) => H(+) + methylglyoxal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2752115", "l": "SPP1 (osteopontin) binds CD44 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043399", "l": "tRNA A64-2'-O-ribosylphosphate transferase activity", "d": ["Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944220", "l": "Association of procollagen type XXIII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964759", "l": "Alternative endo-mannosidase I route (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607721", "l": "Activation of NIK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54884", "l": "L-arginyl-[protein] + NADP(+) = H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39235", "l": "(3R)-hydroxytriacontanoyl-CoA = (2E)-triacontenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981622", "l": "Myoglobin:oxygen dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209163", "l": "CI transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139919", "l": "Translocation of BIM to mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351936", "l": "Caspase-mediated cleavage of claspin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673349", "l": "WNT5 binds FZD7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67437", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388808", "l": "CD28 homodimer binds B7-2 monomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9687625", "l": "ATP binds MLKL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18383", "l": "dihydroxyacetone phosphate + pyruvate => dihydroxyacetone + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392530", "l": "p-S400-Cot phosphorylates NIK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.90", "l": "\"tRNA-dihydrouridine(20a/20b) synthase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754129", "l": "CDK6 inhibitors bind CDK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36504", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA => (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210290", "l": "Interaction of PECAM-1 and SHIP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43474", "l": "14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22309", "l": "O2 + xylitol => D-xylose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50985", "l": "prostaglandin E2(out) => prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34015", "l": "ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 = ergosterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75446", "l": "heme b(in) <=> heme b(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036065", "l": "Defective ARSB does not hydrolyse DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51572", "l": "(25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11701", "l": "H(+) + NADPH + O2 + progesterone => H2O + NADP(+) + testosterone acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Mus musculus)", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49262", "l": "D-galactose 6-phosphate(in) + L-histidyl-[protein] => D-galactose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134962", "l": "DHX36 binds DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20118", "l": "ATP + L-rhamnulose => ADP + H(+) + L-rhamnulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139920", "l": "Translocation of tBID to mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60713", "l": "(+)-artemisinic alcohol + NAD(+) => (+)-artemisinic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56964", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate = a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72269", "l": "chloride(in) + formate(out) => chloride(out) + formate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985594", "l": "MYO9B inactivates RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46556", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + lathosterol + O2 = 7-dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42056", "l": "13-cis-retinol + NAD(+) = 13-cis-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112604", "l": "Phosphorylated STATs are released (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.4", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0050736", "l": "O-malonyltransferase activity", "d": ["Catalysis of the transfer of a malonyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983259", "l": "Kinesins move along microtubules consuming ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877281", "l": "PIAS1 binds p-STAT1 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61731", "l": "a 3-dehydro-D-guloside <=> a 3-dehydro-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202489", "l": "Oligomerization of Bcl10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8934446", "l": "Activated PKC phosphorylates SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75784", "l": "ADP(in) => ADP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23239", "l": "[protein]-L-glutamate 5-O-methyl ester + H2O <=> H(+) + L-glutamyl-[protein] + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810392", "l": "TMEM55B translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37550", "l": "D-glucose 6-phosphate + NAD(+) <=> 3-dehydro-D-glucose 6-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26014", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate = 3-dehydroquinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870686", "l": "BCL2L11 (BIM) gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9035227", "l": "TXN2 binds CysS248-MPST (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71216", "l": "2 Na(+)(out) + thiocyanate(out) => 2 Na(+)(in) + thiocyanate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482772", "l": "Release of platelet cytosolic components (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9620103", "l": "ALDH2 transforms GTN to NO (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340226", "l": "CYGB dioxygenates NO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0015927", "l": "trehalase activity", "d": ["Catalysis of the hydrolysis of trehalose or a trehalose derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73125", "l": "H(+) + rhamnacene + S-adenosyl-L-homocysteine => isorhamnetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33129", "l": "beta-D-glucose 6-phosphate + salicyl alcohol => H2O + salicin-6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23607", "l": "kievitone hydrate <=> H2O + kievitone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34053", "l": "6'''-deamino-6'''-hydroxyneomycin C + acetate => 2'''-acetyl-6'''-hydroxyneomycin C + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31289", "l": "acryloyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20911", "l": "3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018703", "l": "2,4-dichlorophenoxyacetate dehalogenase activity", "d": ["Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid + H+ + 2 e- = Cl- + 4-chlorophenoxyacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53188", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45806", "l": "ADP + L-glutamine hydroxamate + phosphate => ATP + hydroxylamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016286", "l": "small conductance calcium-activated potassium channel activity", "d": ["Enables the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047634", "l": "agmatine N4-coumaroyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaroyl-CoA + agmatine = N-(4-guanidiniumylbutyl)-4-hydroxycinnamamide + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983266", "l": "Kinesins bind microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37506", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003837", "l": "beta-ureidopropionase activity", "d": ["Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34574", "l": "C30 botryococcene + diphosphate + NADP(+) <=> H(+) + NADPH + presqualene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18255", "l": "CO2 + NADPH + pyruvate => (S)-malate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16779", "l": "ADP + H(+) + K(+)(in) + phosphate => ATP + H2O + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28915", "l": "4-aminobutanoate(in) + H(+)(in) = 4-aminobutanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40107", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32469", "l": "glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22570", "l": "ascopyrone P => ascopyrone M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15144", "l": "4-methylphenol + H2O + 4 oxidized [azurin] <=> 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68388", "l": "2 5,6-dihydroxyindole-2-carboxylate + O2 = 2 H2O + 2 indole-5,6-quinone-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086059", "l": "voltage-gated calcium channel activity involved SA node cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015167", "l": "arabitol transmembrane transporter activity", "d": ["Enables the transfer of an arabitol from one side of a membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63702", "l": "mycophenolic acid O-acyl-beta-D-glucuronide + UDP => mycophenolate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30070", "l": "betaine aldehyde + H2O + NADP(+) <=> glycine betaine + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60041", "l": "H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate => (2E)-3-methylhex-2-enoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66046", "l": "(2S)-2-aminobutanoate + H2O + kynurenate => 2-oxobutanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450466", "l": "AUF1:mRNA complex is destroyed (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448958", "l": "Nuclear translocation of p38 MAPK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755757", "l": "SARS-CoV-2 N binds TAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672159", "l": "STAT binds to p-11Y PDGFRA extracellular domain dimers  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42714", "l": "5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(54) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25551", "l": "(+)-copalyl diphosphate <=> abieta-8(14),12-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61252", "l": "H2O + L-valine + O2 = 3-methyl-2-oxobutanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54883", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> (3R)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20217", "l": "H(+) + trimethylamine N-oxide = dimethylamine + formaldehyde", "d": []}, {"i": "EC:4.1.2.32", "l": "\"trimethylamine-oxide aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67706", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30379", "l": "(2E,6E)-farnesyl diphosphate = (+)-beta-chamigrene + diphosphate", "d": []}, {"i": "EC:4.2.3.78", "l": "\"beta-chamigrene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17409", "l": "(S)-coclaurine + S-adenosyl-L-methionine = (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.140", "l": "\"(S)-coclaurine-N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202721", "l": "JAM2 binds JAM3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759882", "l": "Expression of FOXF1 in lateral plate mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5213466", "l": "RIPK3 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14887", "l": "ADP-D-ribose + L-arginyl-[protein] => H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018732", "l": "sulfolactone hydrolase activity", "d": ["Catalysis of the reaction: 4-sulfolactone + OH- = HSO3(-) + maleylacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26157", "l": "D-mannose + NADP(+) => D-glucosone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59079", "l": "bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose <=> 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19991", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167408", "l": "The high affinity receptor complex binds to G-protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60570", "l": "N-acetyl-D-tryptophan => N-acetyl-L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047040", "l": "pteridine reductase activity", "d": ["Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + 2 NADP+ = biopterin + 2 H+ + 2 NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71350", "l": "chloride(out) + L-lysine(out) + 2 Na(+)(out) <=> chloride(in) + L-lysine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050693", "l": "LBD domain binding", "d": ["Binding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709885", "l": "BIL scavenges NO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004089", "l": "carbonate dehydratase activity", "d": ["Catalysis of the reaction: H2CO3 = CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071815", "l": "intermediate-density lipoprotein particle binding", "d": ["Binding to a intermediate-density lipoprotein particle, a triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25144", "l": "3-hydroxy-L-kynurenine + H2O => 3-hydroxyanthranilate + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13410", "l": "7-aminomethyl-7-carbaguanine + 2 NADP(+) => 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50384", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline = 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43822", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71164", "l": "homogentisate + O2 => maleylacetoacetate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46291", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961991", "l": "E2F1 binds the TK1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58974", "l": "H(+) + H2O2 + vanillate => H2O + O2 + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68922", "l": "AMP + diphosphate + NADP(+) + pentanal => ATP + H(+) + NADPH + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77589", "l": "Recognition of AAUAAA sequence by CPSF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38633", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805059", "l": "CK2:FACT phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33136", "l": "malonate(in) + Na(+)(in) => malonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801776", "l": "REG3A binds bacterial phospholipids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.204", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50600", "l": "acetyl-CoA + N-terminal L-seryl-[histone H2A] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68303", "l": "L-seryl-[protein] + tetradecanoyl-CoA <=> CoA + O-tetradecanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11283", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58177", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH => all-trans-lycopaoctaene + 2 diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20515", "l": "2-arylpropionate + CO2 => 2-aryl-2-methylmalonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0043211", "l": "ABC-type carbohydrate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of carbohydrates across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49122", "l": "H2O + NADP(+) + violaceinate => H(+) + NADPH + O2 + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44572", "l": "4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+) = 2-all-trans-heptaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49736", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate = CO2 + deoxyviolacein + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58221", "l": "L-lysyl-[protein] + NAD(+) => H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21542", "l": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate => N-(5-phospho-beta-D-ribosyl)anthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69986", "l": "6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6-deoxoteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68360", "l": "L-xylono-1,4-lactone + O2 = dehydro-L-arabinono-1,4-lactone + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630043", "l": "Defective NTHL1 truncation mutants do not bind thymine glycol (Tg) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37186", "l": "(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate <=> 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61741", "l": "steviolmonoside + UDP-alpha-D-glucose => H(+) + steviolbioside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34895", "l": "ATP + H2O + selenite(out) = ADP + H(+) + phosphate + selenite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56313", "l": "3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O => 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174171", "l": "Association of Cyclin A with the APC/C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29898", "l": "ATP + H2O + L-glutamine(out) <=> ADP + H(+) + L-glutamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052808", "l": "reduced coenzyme F420:NADP+ oxidoreductase activity", "d": ["Catalysis of the reaction: NADP+ + 1,5-dihydrocoenzyme F420 = NADPH + H+ + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707690", "l": "BACH1 binds MAFK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592387", "l": "Fibulin binds elastic fibres (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34245", "l": "diphosphate + Mo-molybdopterin guanine dinucleotide => GTP + H(+) + Mo-molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73709", "l": "ATP(out) + UDP(in) => ATP(in) + UDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43236", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989761", "l": "Expression of APOA5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682011", "l": "LC3 binds ATG7 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008902", "l": "hydroxymethylpyrimidine kinase activity", "d": ["Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-phosphomethylpyrimidine + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70960", "l": "D-tyrosine + H2O + O2 => 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010473", "l": "GDP-galactose:myoinositol-1-phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: GDP-L-galactose + myo-inositol 1-phosphate = alpha-L-galactose-1-phosphate + GDP-myoinositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635861", "l": "NUMB:ITCH binds GLI1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33660", "l": "H(+) + N-tetracosanoylsphinganine + NADPH + O2 => H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21005", "l": "(R)-pantolactone + A => 2-dehydropantolactone + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58185", "l": "H(+) + NADPH + 2 phytyl diphosphate => (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22863", "l": "ATP + H(+) + nicotinate beta-D-ribonucleotide <=> deamido-NAD(+) + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65076", "l": "dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23333", "l": "(2R)-3-phosphoglycerate + GTP => (2R)-3-phospho-glyceroyl phosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75255", "l": "mangiferin + O2 = 3'-dehydromangiferin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990080", "l": "2-phenylethylamine receptor activity", "d": ["Combining with the biogenic amine 2-phenylethylamine to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62191", "l": "9alpha-copalyl diphosphate <=> diphosphate + syn-isopimara-7,15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61715", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine <=> 2 Fe(III)-[cytochrome b5] + H2O + N(delta)-methyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63019", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61165", "l": "kaempferol + UDP-beta-L-rhamnose => H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873946", "l": "OTUD3 deubiquitinates PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877902", "l": "Activated AR binds RUNX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69777", "l": "beta-ylangene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25768", "l": "3-carboxy-2-oxobutanoate + H(+) => 2-oxobutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202127", "l": "eNOS synthesizes NO (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37205", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14569", "l": "propane-1,2-diol = H2O + propanal", "d": []}, {"i": "EC:4.2.1.28", "l": "\"propanediol dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791109", "l": "GADD45A binds PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019151", "l": "galactose 1-dehydrogenase activity", "d": ["Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004331", "l": "fructose-2,6-bisphosphate 2-phosphatase activity", "d": ["Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9609921", "l": "SGTA binds Tail-anchored protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72593", "l": "D-glucuronate(in) + H(+)(in) => D-glucuronate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198347", "l": "AKT phosphorylates BAD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106368", "l": "(deoxy)nucleoside phosphate kinase activity, dTTP as phosphate donor", "d": ["Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dTTP = a 2'-deoxyribonucleoside 5'-diphosphate + dTDP."]}, {"i": "RHEA:62132", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dTTP = a 2'-deoxyribonucleoside 5'-diphosphate + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66497", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23184", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate = (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13249", "l": "(R)-2-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.268", "l": "\"2-(R)-hydroxypropyl-CoM dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49298", "l": "L-histidyl-[protein] + L-sorbose 1-phosphate(in) => keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018739", "l": "4-hydroxybenzoyl-CoA thioesterase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35718", "l": "(2S,3S)-versiconal hemiacetal acetate + H2O <=> (2S-3S)-versiconal hemiacetal + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669013", "l": "EDA-3 binds EDA2R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63669", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9660557", "l": "RAS:GTP binds RAL GDS proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097641", "l": "alpha-ketoglutarate-dependent xanthine dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate (alpha-ketoglutarate) + O2 + xanthine = CO2 + succinate + urate."]}, {"i": "RHEA:43120", "l": "2-oxoglutarate + O2 + xanthine = CO2 + succinate + urate", "d": []}, {"i": "EC:1.14.11.48", "l": "\"xanthine dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59389", "l": "a fatty acid ester + H2O => a fatty acid + an aliphatic alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428749", "l": "Activated TP receptor binds G-proten Gq (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30224", "l": "2 Fe(III)-[cytochrome c] + hydrogen sulfide => 2 Fe(II)-[cytochrome c] + H(+) + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47265", "l": "2,6,10,14-tetramethylpentadecanoate + ATP + CoA => AMP + diphosphate + pristanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15513", "l": "ATP + keto-D-tagatose = ADP + H(+) + keto-D-tagatose 6-phosphate", "d": []}, {"i": "EC:2.7.1.101", "l": "\"tagatose kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46845", "l": "4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45395", "l": "H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665748", "l": "FMNL2 binds RHOC:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31542", "l": "(2S)-naringenin + S-adenosyl-L-methionine <=> (2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14202", "l": "D-lyxose => D-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.59", "l": "\"tryptase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632652", "l": "Hh-Npp binds CDON and PTCH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672978", "l": "RAF phosphorylates MAP2K dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810843", "l": "Envoplakin binds periplakin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102171", "l": "DMNT synthase activity", "d": ["Catalysis of the reaction: H+ + (3S,6E)-nerolidol + NADPH + O2 <=> (E)-4,8-dimethyl-1,3,7-nonatriene + buten-2-one + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799761", "l": "TP53 binds PPP1R13L (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67690", "l": "2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate => 2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799332", "l": "ATR phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21207", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol <=> a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353323", "l": "Ligation of newly synthesized repair patch to incised DNA in GG-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12577", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose => (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58171", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-5-epi-eremophilene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0017136", "l": "NAD-dependent histone deacetylase activity", "d": ["Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050477", "l": "acyl-lysine deacylase activity", "d": ["Catalysis of the reaction: H2O + N6-acyl-L-lysine = L-lysine + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203700", "l": "eNOS translocation from Golgi to Caveolae (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856525", "l": "ANGPTL8 binds ANGPTL3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61176", "l": "(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49950", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2 => (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917700", "l": "MVB Vesicle Formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69907", "l": "2 Na(+)(out) + uridine(out) = 2 Na(+)(in) + uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8957241", "l": "TP73 tetramer translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15804", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173739", "l": "Spontaneous hydrolysis of C3 thioester (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60440", "l": "H2O + methyl acetate = acetate + H(+) + methanol", "d": []}, {"i": "EC:3.1.1.114", "l": "\"methyl acetate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14630", "l": "ATP + N-acetyl-L-glutamate => ADP + N-acetyl-L-glutamyl 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14736", "l": "Ag(+)(in) + ATP + H2O <=> ADP + Ag(+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43040", "l": "hexadecanoyl-CoA + hexadecasphinganine = CoA + H(+) + N-hexadecanoylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17646", "l": "H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] => N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983707", "l": "SYK autophosphorylates at the activated BCR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75882", "l": "Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) + L-proline betaine <=> methyl-Co(III)-[quaternary-amine-specific corrinoid protein] + N-methyl-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40697", "l": "1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17169", "l": "acetyl-CoA + alpha-D-galactosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": []}, {"i": "EC:2.3.1.276", "l": "\"galactosamine-1-phosphate N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390886", "l": "HRH4 binds Hist (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709842", "l": "MAVS binds TOMM70 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53019", "l": "chlorohydroquinone + 2 glutathione <=> chloride + glutathione disulfide + H(+) + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64953", "l": "dCDP + H2O => dCMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43022", "l": "2-aminoprop-2-enoate + L-homocysteine => L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15618", "l": "Fe(3+) + Fe(II)-[cytochrome c] => Fe(2+) + Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60719", "l": "(1R,3R)-chrysanthemal + H2O + NADP(+) <=> (1R,3R)-chrysanthemate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37176", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050533", "l": "5-phytase activity", "d": ["Catalysis of the reaction: H2O + myo-inositol hexakisphosphate = phosphate + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83788", "l": "Binding of TFIIIC to Type 2 promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39078", "l": "(2E)-dodecenedioyl-CoA + H2O <=> (3S)-hydroxydodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29260", "l": "(2R,3R)-tartrate(out) + succinate(in) => (2R,3R)-tartrate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44859", "l": "(9Z)-octadecenoyl-CoA + (R)-carnitine <=> CoA + O-(9Z)-octadecenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33239", "l": "L-threonine + NAD(+) = aminoacetone + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12388", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] = 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72165", "l": "chloride(in) + 2 Na(+)(in) + O-butanoyl-(R)-carnitine(in) => chloride(out) + 2 Na(+)(out) + O-butanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71164", "l": "homogentisate + O2 => maleylacetoacetate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66323", "l": "2',3'-cGAMP(out) <=> 2',3'-cGAMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57872", "l": "(E)-2,4-dihydroxycinnamoyl-CoA = CoA + umbelliferone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23258", "l": "adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate => adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22594", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate => (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54086", "l": "archaeosine(15) in tRNA + L-glutamate => 7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445700", "l": "Myosin Binds ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3797196", "l": "AP-1 transcription factor binds IGFBP7 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950504", "l": "IL27 binds CRLF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031864", "l": "EP1 subtype prostaglandin E2 receptor binding", "d": ["Binding to an EP1 subtype prostaglandin E2 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.111", "l": "\"3-(imidazol-5-yl)lactate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008695", "l": "3-phenylpropionate dioxygenase activity", "d": ["Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65449", "l": "butanoyl-CoA + ethanol => CoA + ethyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008681", "l": "2-octaprenyl-6-methoxyphenol hydroxylase activity", "d": ["Catalysis of the reaction: 2-octaprenyl-6-methoxyphenol + O2 + 4 H+ = 2-octaprenyl-6-methoxy-1,4-benzoquinol + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604368", "l": "Autocatalytic activation of bound proMMP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69210", "l": "(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ADP + H(+) + phosphate => (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018529", "l": "nitrilotriacetate monooxygenase activity", "d": ["Catalysis of the reaction: nitrilotriacetate + NADH + H+ + O2 = NAD+ + H2O + glyoxylate + iminodiacetate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015514", "l": "nitrite efflux transmembrane transporter activity", "d": ["Enables the transfer of nitrite from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "ic": "70.744066580938323", "identifiers": [{"i": "GO:0005319", "l": "lipid transporter activity", "d": ["Enables the directed movement of lipids into, out of or within a cell, or between cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59052", "l": "D-lysine + H(+) = cadaverine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34745", "l": "13-methyltetradecanal + phosphoethanolamine => 15-methylhexadecasphinganine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21947", "l": "ATP + D-cellobiose <=> 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72848", "l": "adenosine 3',5'-bisphosphate(in) + ADP(out) => adenosine 3',5'-bisphosphate(out) + ADP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34169", "l": "2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+) => 2,6-dihydroxypseudooxynicotine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012542", "l": "IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4411402", "l": "Activation of NLK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55885", "l": "[aequorin] + 3 Ca(2+) => [aequorin]--dioxetanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23142", "l": "D-ribose 5-phosphate + H(+) + nicotinamide => beta-nicotinamide D-ribonucleotide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75741", "l": "10-oxooctadecanoate + NAD(+) => 10-oxo-(11E)-octadecenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417842", "l": "P2Y10 receptor can bind to LPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63924", "l": "ATP + N(4)-acetylcytidine = ADP + H(+) + N(4)-acetylcytidine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33294", "l": "L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.28", "l": "\"aromatic-L-amino-acid decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0016174", "l": "NAD(P)H oxidase H2O2-forming activity", "d": ["Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31221", "l": "5-hydroxy-L-kynurenine + H(+) => 5-hydroxykynurenamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13969", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + GTP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + diphosphate + GMP", "d": []}, {"i": "EC:6.5.1.5", "l": "\"RNA 3'-terminal-phosphate cyclase (GTP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55134", "l": "AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate => ATP + D-alanine + holo-[D-alanyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964274", "l": "G alpha (12) binds BTK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54214", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphocholine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19880", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825275", "l": "Expression of DLL1 in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730892", "l": "Recruitment of VAV to p-SLP-76 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19584", "l": "N(6)-dimethylallyladenine + S-adenosyl-L-methionine <=> discadenine + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33352", "l": "hexacosanoyl-CoA + sphinganine => CoA + H(+) + N-hexacosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13616", "l": "beta-D-fructose 6-phosphate + diphosphate <=> beta-D-fructose 1,6-bisphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57605", "l": "a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698333", "l": "Spike trimer moves into the ERGIC membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45183", "l": "2 (E)-4-coumaroyl-CoA + spermidine <=> 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853762", "l": "RET dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57812", "l": "1-chloro-2-nitrobenzene + NADH + O2 = 3-chlorocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983700", "l": "SYK binds the activated BCR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75885", "l": "ADP-1-deoxy-1,O(4)-didehydro-D-ribose + nicotinamide => NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16526", "l": "2-dehydro-3-deoxy-D-galactonate + ATP => 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73800", "l": "SAICAR => AICAR + Fumarate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786789", "l": "FLT3LG dimer binds FLT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.16", "l": "\"dihydrophenazinedicarboxylate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29109", "l": "NAD(+) + ubiquinol-8 => H(+) + NADH + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202966", "l": "Caspase mediated cleavage of HIP-55 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186786", "l": "Autophosphorylation of PDGF beta receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45339", "l": "(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine <=> [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72083", "l": "ADP-alpha-D-ribose 1'',2''-cyclic phosphate + H2O = ADP-alpha-D-ribose 1''-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17743", "l": "3-dehydroshikimate + H(+) + NADH => NAD(+) + shikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54178", "l": "a long-chain fatty acyl-[ACP] + H(+) + NADPH => a long-chain fatty aldehyde + holo-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.30", "l": "\"isobutylamine N-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0048256", "l": "flap endonuclease activity", "d": ["Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696358", "l": "TREM,CD300 binds lipids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31961", "l": "9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71379", "l": "D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out) = D-aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29205", "l": "dimethyl sulfide + H2O + menaquinone-8 => dimethyl sulfoxide + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430190", "l": "p-SLP-76 binds NCK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418925", "l": "ADORA2A,B bind Ade-Rib (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51715", "l": "keto-D-tagatose 6-phosphate <=> keto-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800793", "l": "PIDD1 translocates to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34860", "l": "3-oxocyclopentanecarbonitrile + 2 H2O => 3-oxocyclopentanecarboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977629", "l": "Displacement of C2a/Bb by CR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36455", "l": "ATP + H2O + L-alanylglycine(out) = ADP + H(+) + L-alanylglycine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74458", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40966", "l": "4 2-aminophenol + 3 O2 <=> 2 2-aminophenoxazin-3-one + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19582", "l": "N(6)-dimethylallyladenine + S-adenosyl-L-methionine => discadenine + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49492", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate = 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66915", "l": "avenanthramide C + S-adenosyl-L-methionine <=> avenanthramide B + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110130", "l": "ribitol-5-phosphatase activity", "d": ["Catalysis of the reaction: ribitol-5-phosphate + H20 = ribitol + phosphate."]}, {"i": "RHEA:47648", "l": "D-ribitol 5-phosphate + H2O = phosphate + ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11740", "l": "2 glutathione + NADP(+) = glutathione disulfide + H(+) + NADPH", "d": []}, {"i": "EC:1.8.1.7", "l": "\"glutathione-disulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53159", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24274", "l": "H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+) => H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14728", "l": "2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156682", "l": "PLK1 phosphorylates NUDC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53958", "l": "4-aminobutanoyl-[BtrI ACP] + CO2 => gamma-L-glutamyl-[BtrI ACP] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36238", "l": "1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26241", "l": "geranylgeranyl diphosphate = diphosphate + elisabethatriene", "d": []}, {"i": "EC:4.2.3.41", "l": "\"elisabethatriene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23130", "l": "4-hydroxybutanoyl-CoA + AMP + diphosphate => 4-hydroxybutanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28083", "l": "(2S)-ethylmalonyl-CoA + NADP(+) => (2E)-butenoyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55148", "l": "a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) = a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46172", "l": "ATP + butanoate + CoA = AMP + butanoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933525", "l": "Phosphorylation and release of IRF7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001596", "l": "angiotensin type I receptor activity", "d": ["An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981926", "l": "RAC1 and CDC42 activate PAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53237", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] => (24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247847", "l": "WLS is endocytosed to the early endosome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-901047", "l": "Binding of ERp57 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56841", "l": "5-amino-2-hydroxybenzoate + O2 => (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31148", "l": "3,4-dihydroxyphenylethyleneglycol + NAD(+) => 3,4-dihydroxymandelaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54354", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72526", "l": "1,6-dihydroxyphenazine + S-adenosyl-L-methionine <=> 1-hydroxy-6-methoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15175", "l": "2 H2O + NADP(+) => H(+) + H2O2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64491", "l": "acetyl-CoA + 5 H(+) + holo-[ACP] + 5 malonyl-CoA <=> 3,5,7,9,11-pentaoxododecanoyl-[ACP] + 5 CO2 + 6 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49477", "l": "2 H2O + L-1-piperideine-6-carboxylate + NAD(+) => H(+) + L-2-aminoadipate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19893", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP", "d": []}, {"i": "EC:2.7.4.7", "l": "\"phosphooxymethylpyrimidine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694525", "l": "M protein gets N-glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18671", "l": "adenine + D-ribose => adenosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004736", "l": "pyruvate carboxylase activity", "d": ["Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H+ + oxaloacetate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75528", "l": "(R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMNH2 + O2 => benzaldehyde + FMN + H(+) + H2O + N-acetyl-S-hydroxy-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19464", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP <=> 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9727188", "l": "ATP4A:ATP4B binds PPIs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3134914", "l": "Beta-catenin migrates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33100", "l": "acetyl-CoA + spermine => CoA + H(+) + N(1)-acetylspermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41271", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682010", "l": "ATG10:ATG12 binds ATG5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69152", "l": "Removal of remaining Flap (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20670", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15028", "l": "S-adenosyl-L-methionine + xanthosine <=> 7-methylxanthosine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017041", "l": "galactosylgalactosylglucosylceramidase activity", "d": ["Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035373", "l": "chondroitin sulfate proteoglycan binding", "d": ["Binding to a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58556", "l": "15alpha-stemmadenine intermediate II + H2O = (16S)-deshydroxymethyl-stemmadenine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.96", "l": "\"carboxynorspermidine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197564", "l": "NOTCH2 stimulates transcription of HES5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16447", "l": "daidzein + H(+) + H2O => (2R,3S)-2,4',7-trihydroxyisoflavanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171106", "l": "LDLR:LDL complex => LDLR + LDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23402", "l": "5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+) => 7,8-dihydroxykynurenate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784734", "l": "PCSK9 binds LDLR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14857", "l": "(indol-3-yl)acetate + ATP + L-lysine = ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate", "d": []}, {"i": "EC:6.3.2.20", "l": "\"indoleacetate--lysine synthetase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75963", "l": "15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173680", "l": "Activation of C5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45553", "l": "H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12630", "l": "2-oxoglutarate + L-hyoscyamine + O2 => (6S)-6-hydroxyhyoscyamine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5604929", "l": "Activated protein C binds Protein S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396113", "l": "Dystroglycan binds AGRN and HSPG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013978", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.n1", "l": "\"cytokinin riboside 5'-monophosphate phosphoribohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050316", "l": "T2-induced deoxynucleotide kinase activity", "d": ["Catalysis of the reactions: ATP + dGMP = ADP + dGDP, and ATP + dTMP = ADP + dTDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389352", "l": "Translocation of Vav1 to CD28 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76022", "l": "cortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 18-hydroxycortisol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71183", "l": "L-kynurenine(out) + L-tryptophan(in) = L-kynurenine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640195", "l": "RRAGA,B hydrolyzes GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847537", "l": "RAB43:GTP binds USP8NL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110319", "l": "Elongation by POLH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9725855", "l": "NR3C2 binds NR3C2 antagonists (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429157", "l": "ABCC4 accumulation of dense granule contents (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211951", "l": "CYP1B1 4-hydroxylates EST17b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9659820", "l": "RB1 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9620456", "l": "sGC stimulators bind sGC:NO (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46970", "l": "AH2 + isopentenyldehydrorhodopin => A + dihydroisopentenyldehydrorhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70211", "l": "2-oxoglutarate + GDP-D-glycero-alpha-D-manno-heptose = (S)-2-hydroxyglutarate + GDP-D-glycero-4-keto-alpha-D-lyxo-heptose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13346", "l": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] => diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56083", "l": "[Rab1 protein]-L-serine + CDP-choline <=> [Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10100", "l": "a sterol ester + H2O = a fatty acid + a sterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74550", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + talarodiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40805", "l": "3,6-anhydro-L-galactonate + 2 H(+) + NADPH => 3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42739", "l": "guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730892", "l": "Recruitment of VAV to p-SLP-76 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36649", "l": "CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine => 2-hydroxyhexadecanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18243", "l": "(2R,5S)-2,5-diaminohexanoate => D-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32891", "l": "(1S,5S)-alpha-pinene + H(+) + NADH + O2 = alpha-pinene oxide + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.155", "l": "\"alpha-pinene monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63082", "l": "A + AMP + diphosphate + ilicicolin B => AH2 + ATP + ilicicolinate B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55385", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate => 6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65471", "l": "1-propanol + acetyl-CoA <=> CoA + propyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25622", "l": "geranylgeranyl diphosphate => tuberculosinyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.30", "l": "\"flavin reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34960", "l": "(R)-carnitine(in) => (R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66071", "l": "4-methyl-2-oxopentanoate + L-kynurenine <=> H2O + kynurenate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809521", "l": "BPIF binds bacteria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38394", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213200", "l": "Release of endostatin-like peptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103107", "l": "castasterone 23-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: castasterone + UDP-alpha-D-glucose <=> castasterone-23-O-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73736", "l": "O2 + trans-resveratrol => 3,5-dihydroxybenzaldehyde + 4-hydroxybenzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0004683", "l": "calmodulin-dependent protein kinase activity", "d": ["Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392748", "l": "L1 binds to AP-2 Clathrin complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.5.-", "l": "\"Triphosphoric monoester hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0106017", "l": "phosphatidylinositol-3,4-bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44162", "l": "myo-inositol + phosphate => 1D-myo-inositol 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938108", "l": "SERPINB13 binds cathepsin L (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47111", "l": "cholate + taurine <=> H2O + taurocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50483", "l": "acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050631", "l": "corydaline synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 2 NADPH + palmatine = S-adenosyl-L-homocysteine + corydaline + 2 NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16024", "l": "oxaloacetate <=> enol-oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18521", "l": "licodione + S-adenosyl-L-methionine = 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.65", "l": "\"licodione 2'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70540", "l": "GDP-beta-L-fucose + L-threonyl-[EGF-like domain protein] => 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63093", "l": "H(+) + ilicicolin A + NADPH + O2 => H2O + ilicicolin A epoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33693", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate => 2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21694", "l": "CMP + 2 H(+) + sn-glycerol 3-phosphate => CDP-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59422", "l": "formaldehyde + H2O2 + NH4(+) => H2O + methylamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944262", "l": "Association of procollagen type X (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189488", "l": "UROS transforms HMB to URO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23004", "l": "a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36918", "l": "(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848930", "l": "PTK6 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417842", "l": "P2Y10 receptor can bind to LPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71886", "l": "GMP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-GMP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-179410", "l": "Association of Nek2A with MCC:APC/C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51455", "l": "O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate <=> beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32586", "l": "dihydrocarvone + H(+) + NADPH + O2 <=> 6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032560", "l": "guanyl deoxyribonucleotide binding", "d": ["Binding to a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.29", "l": "\"glycerate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170159", "l": "Translocation of Cdc25 to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21558", "l": "[calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine => [calmodulin]-L-lysine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247837", "l": "WNT ligands traffic to the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102663", "l": "gibberellin A34,2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A34 + 2-oxoglutarate + O2 <=> H+ + gibberellin A34-catabolite + succinate + carbon dioxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45000", "l": "(R)-carnitine + 3-hydroxybutanoyl-CoA = CoA + O-3-hydroxybutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30605", "l": "AH2 + all-trans-phytofluene => 15-cis-phytoene + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13839", "l": "4,5-dihydroxyphthalate + H(+) + NADH => cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75040", "l": "acetyl-CoA(in) => acetyl-CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66221", "l": "asc-omegaC7-CoA + O2 => asc-omegaDeltaC7-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72218", "l": "2 hydrogencarbonate(out) + Na(+)(out) <=> 2 hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0043138", "l": "3'-5' DNA helicase activity", "d": ["Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39568", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22021", "l": "ATP + H2O + molybdate(out) => ADP + H(+) + molybdate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56498", "l": "gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => gypsogenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9794444", "l": "ALB binds Cipro (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13270", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O => an N-acylsphing-4-enine + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008412", "l": "CDK4 phosphorylates RUNX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41034", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227709", "l": "Activated MDA5 binds IPS-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.8", "l": "\"guanylate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72095", "l": "Internal Methylation of mRNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225949", "l": "Binding of CBL to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977237", "l": "IRAK2 binds to IRAK4 associated with activated TLR : MyD88 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-622310", "l": "Activated NOD1 oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-555065", "l": "Formation of clathrin coated vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25988", "l": "(5R)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607737", "l": "BCL10 oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0045145", "l": "single-stranded DNA 5'-3' DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689649", "l": "BAP1 binds BRCA1:BARD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814153", "l": "ADO oxidises 2AET to HTAU (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63293", "l": "N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18785", "l": "A + gibberellin A12 aldehyde + H2O = AH2 + gibberellin A12 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32834", "l": "an R-cob(III)alamin(in) <=> an R-cob(III)alamin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.52", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68954", "l": "Mcm2-7 is phosphorylated by DDK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71887", "l": "GTP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23868", "l": "(1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone", "d": []}, {"i": "EC:4.1.3.35", "l": "\"(1-hydroxycyclohexan-1-yl)acetyl-CoA lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632738", "l": "DDIT4 binds 14-3-3 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50262", "l": "(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate => 11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53642", "l": "(-)-alpha-amorphene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570528", "l": "SUMOylation of XPC with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376419", "l": "Formation of NR-MED1 Coactivator Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61581", "l": "(3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+) => (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20079", "l": "2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(18) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008730", "l": "L(+)-tartrate dehydratase activity", "d": ["Catalysis of the reaction: L-tartrate = H2O + oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39295", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709098", "l": "DHFR dimer reduces FOLA to DHF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981926", "l": "RAC1 and CDC42 activate PAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139917", "l": "tBID activates BAX protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25057", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 <=> (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12185", "l": "(S,S)-butane-2,3-diol + NAD(+) => (S)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202722", "l": "CD48 binds CD244 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1015702", "l": "Expression of IFN-induced genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23630", "l": "a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12622", "l": "H(+) + L-aspartate => CO2 + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65192", "l": "2 2-oxoglutarate + 2 O2 + preaustinoid A = berkeleytrione + 2 CO2 + H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70372", "l": "3-oxosphinganine + decanoyl-CoA => CoA + H(+) + N-decanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5671772", "l": "p-T38-PPP1R14A binds MLCP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22212", "l": "(2R,3R)-tartrate = (2R,3S)-tartrate", "d": []}, {"i": "EC:5.1.2.5", "l": "\"tartrate epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39838", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332235", "l": "CBL binds TGFBR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209925", "l": "DIT and MIT combine to form triiodothyronine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034885", "l": "gamma-N-formylaminovinylacetate hydrolase activity", "d": ["Catalysis of the reaction: gamma-N-formylaminovinylacetate + H2O = gamma-aminovinylacetate + HCOOH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40338", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218847", "l": "PAK2 binds NCK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336454", "l": "MMGT1 transports Mg2+ from cytosol to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102208", "l": "2-polyprenyl-6-hydroxyphenol methylase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a 3-(all-trans-polyrenyl)benzene-1,2-diol <=> S-adenosyl-L-homocysteine + H+ + a 2-methoxy-6-(all-trans-polyprenyl)phenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30733", "l": "(2E)-butenoyl-CoA + FADH2 => butanoyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75324", "l": "chloride(out) + D-leucine(out) + 2 Na(+)(out) => chloride(in) + D-leucine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31800", "l": "4-amino-5-aminomethyl-2-methylpyrimidine + H2O => 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72103", "l": "Formation of pre-mRNPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396370", "l": "VTN binds collagens II, III and V (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218821", "l": "PDK1 phosphorylates PKC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53538", "l": "(13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5444523", "l": "Formation of MSH1:PMS2 Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176445", "l": "SMURF2 binds SMAD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706315", "l": "Active FLT3 binds to SH2B3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204600", "l": "Basigin homodimerises (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043779", "l": "cobalt-precorrin-5A acetaldehyde-lyase activity", "d": ["Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803892", "l": "SFN dimer binds BAX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669906", "l": "Ligand-independent dimerization of KIT juxtamembrane domain mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202966", "l": "Caspase mediated cleavage of HIP-55 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42511", "l": "6-acetamido-2-oxohexanoate + H2O + NAD(+) <=> 5-acetamidopentanoate + CO2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029454", "l": "Autophosphorylation of PAK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72970", "l": "4-methyl-2-oxopentanoate(out) + 2 Na(+)(out) <=> 4-methyl-2-oxopentanoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371554", "l": "HSF1 acetylation at Lys80 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22709", "l": "H2O + S-acylglutathione => a carboxylate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102594", "l": "cyanidin 7-O-glucoside acyltransferase(acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3,7-di-O-beta-D-glucoside betaine + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> cyanidin 3-O-glucoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32122", "l": "GDP-valienol + validamine 7-phosphate <=> GDP + H(+) + validoxylamine A 7'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18419", "l": "CMP + ganglioside GM3 (d18:1(4E)) + H(+) => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41990", "l": "5alpha-pregnane-3,20-dione + H(+) + NADH => 3beta-hydroxy-5alpha-pregnane-20-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875443", "l": "USP8 deubiquitinates LRIG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396029", "l": "Latent TGF-beta-3 binds integrins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156678", "l": "Activation of Cdc25C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3899291", "l": "SUMOylation of EP300 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57557", "l": "(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56018", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) => H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73601", "l": "CDP(out) + CTP(in) => CDP(in) + CTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800315", "l": "MST1 binds MST1R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30903", "l": "demethylspheroidene + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + spheroidene", "d": []}, {"i": "EC:2.1.1.210", "l": "\"demethylspheroidene O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70092", "l": "ethanol + o-quinone methide => hydroxyclavatol ethyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008326", "l": "RUNX2 binds HDAC4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296233", "l": "T2Rs bind bitter-tasting compounds (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25368", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) => H(+) + momilactone A + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28342", "l": "dITP + H2O = dIMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50469", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH => 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60458", "l": "3',3'-cUAMP + 2 diphosphate => ATP + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.990900157612501", "identifiers": [{"i": "GO:0016209", "l": "antioxidant activity", "d": ["Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9706837", "l": "AR binds AR antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31568", "l": "bisphenol A + H(+) + NADH + O2 => 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213195", "l": "Formation of anchoring fibrils (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50206", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193700", "l": "p75NTR ICD signals to NF-kB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981657", "l": "IL34 dimer binds PTPRZ1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42195", "l": "(9Z)-pentadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-pentadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31845", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA => 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046964", "l": "3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity", "d": ["Enables the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29048", "l": "a menaquinone + 2 H(+)(in) + H2 => a menaquinol + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202466", "l": "Interaction of Bcl10 to CARMA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70069", "l": "a (22S)-22-hydroxy C29-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C29-steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682598", "l": "ATM phosphorylates HERC2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74730", "l": "Insulin degradation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27729", "l": "5-dehydro-4-deoxy-D-glucarate <=> 2-hydroxy-3-oxopropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168848", "l": "tBID binds to inactive BAK protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047946", "l": "glutamine N-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169680", "l": "IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018579", "l": "protocatechuate 4,5-dioxygenase activity", "d": ["Catalysis of the reaction: protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76017", "l": "(3R)-hydroxybutanoate dimer + (R)-3-hydroxybutanoate + H(+) => (3R)-hydroxybutanoate trimer + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70143", "l": "6alpha-hydroxy-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = 28-nortyphasterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32985", "l": "2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168046", "l": "Collagen type XII degradation by MMP12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57719", "l": "hydrogencarbonate + NH4(+) <=> carbamate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375138", "l": "CDO binds BOC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474266", "l": "Formation of collagen fibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56235", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O <=> [(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140033", "l": "acetylation-dependent protein binding", "d": ["Binding to a protein upon acetylation of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928656", "l": "gamma-secretase cleaves EPHB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607747", "l": "TRAF6 binds MALT1 oligomers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0038057", "l": "TNFSF11 binding", "d": ["Binding to tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450466", "l": "AUF1:mRNA complex is destroyed (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34929", "l": "glutathione + glutathioselenol + NADP(+) => H(+) + NADPH + selenodiglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61980", "l": "H(+) + NADPH + ubiquinone-10 = NADP(+) + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15589", "l": "2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate", "d": []}, {"i": "EC:2.6.1.72", "l": "\"D-4-hydroxyphenylglycine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74718", "l": "Internalisation of the insulin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20308", "l": "4-hydroxybenzaldehyde + H2O + NAD(+) <=> 4-hydroxybenzoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28779", "l": "4-hydroxy-L-threonine = glycine + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25079", "l": "(2S)-2-isopropyl-3-oxosuccinate + H(+) => 4-methyl-2-oxopentanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72663", "l": "De novo formation of eIF2:GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697064", "l": "lprG binds to LAM,LM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12745", "l": "a 1,4-lactone + H2O = a 4-hydroxyacid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27736", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate => 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395764", "l": "atREs binds to nascent CM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13724", "l": "H2O + testololactone <=> H(+) + testolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29254", "l": "2 H(+)(out) + Na(+)(in) <=> 2 H(+)(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2314678", "l": "ASA- acetylates PTGS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46366", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O => an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54511", "l": "all-trans-heptaprenyl diphosphate <=> beta-heptaprene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047857", "l": "dihydrouracil oxidase activity", "d": ["Catalysis of the reaction: 5,6-dihydrouracil + O2 = H2O2 + uracil."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30083", "l": "4 Cu(+) + 4 H(+) + O2 = 4 Cu(2+) + 2 H2O", "d": []}, {"i": "EC:1.16.3.4", "l": "\"cuproxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75117", "l": "all-trans-13,14-dihydroretinal + H(+) + NADH => all-trans-13,14-dihydroretinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-178208", "l": "SMAD7 binds to SMURF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003972", "l": "RNA ligase (ATP) activity", "d": ["Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52628", "l": "an N-fatty-acyl-L-alpha-amino acid + H2O = a fatty acid + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40064", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O => 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59738", "l": "CoA + S-tetradecanoyl-L-cysteinyl-[protein] => L-cysteinyl-[protein] + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71298", "l": "chloride(out) + 2 Na(+)(out) + O-propanoyl-(R)-carnitine(out) <=> chloride(in) + 2 Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0072570", "l": "ADP-D-ribose binding", "d": ["Binding to ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64936", "l": "dGTP + H2O = dGDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69552", "l": "dihydroxyacetone phosphate + L-glutamate = (S)-serinol phosphate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63163", "l": "H2O + N-(15Z-tetracosenoyl)-taurine <=> (15Z)-tetracosenoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13305", "l": "(E)-sinapate + UDP-alpha-D-glucose = 1-O-(trans-sinapoyl)-beta-D-glucose + UDP", "d": []}, {"i": "EC:2.4.1.120", "l": "\"sinapate 1-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009017", "l": "succinylglutamate desuccinylase activity", "d": ["Catalysis of the reaction: N-succinyl-L-glutamate + H2O = L-glutamate + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454916", "l": "The ABCC family mediates organic anion transport (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75683", "l": "(12R,13S)-epoxy-(9Z)-octadecenoate + O2 = (12R,13S)-epoxy-(10R)-hydroperoxy-(8E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13384", "l": "acetate + an acyl-CoA <=> a carboxylate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50480", "l": "acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41085", "l": "(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58809", "l": "2',3'-cGAMP + 2 H2O => AMP + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670673", "l": "FIX is secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69844", "l": "a 5,6-dihydrouridine in RNA + NAD(+) => a uridine in RNA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607746", "l": "PKC-delta is activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18815", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate => (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29228", "l": "H(+)(in) + indole(in) => H(+)(out) + indole(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977371", "l": "Factor I inactivates Factor H-boundC3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928654", "l": "Clathrin internalises EPH:EFN complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71459", "l": "H2O + substance P = L-Leu-L-Met-NH2 + substance P(1-9)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56102", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate => [small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112342", "l": "Inactivation of MAP2K1 by CDK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16516", "l": "(S)-lactate + O2 <=> acetate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5622129", "l": "FABP5 binds atRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139893", "l": "Granzyme-B activates BID by cleavage (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43926", "l": "H(+) + NADH + pregn-5-ene-3,20-dione => NAD(+) + pregnenolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75760", "l": "(9Z,11E)-octadecadienoate + H2O => 10-hydroxy-(11E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14692", "l": "4-chlorophenylacetate + NADH + O2 <=> 3,4-dihydroxyphenylacetate + chloride + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24035", "l": "sucrose <=> 6-O-alpha-D-glucopyranosyl-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48200", "l": "H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA = reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15744", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) <=> 2,5-dichlorohydroquinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798748", "l": "Exocytosis of secretory granule lumen proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0032554", "l": "purine deoxyribonucleotide binding", "d": ["Binding to a purine deoxyribonucleotide, any compound consisting of a purine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043824", "l": "succinylglutamate-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: N-succinyl-L-glutamate 5-semialdehyde + H2O + NAD+ = N-succinyl-L-glutamate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990430", "l": "extracellular matrix protein binding", "d": ["Binding to a protein that is part of an extracellular matrix."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55639", "l": "ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O <=> AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.36", "l": "\"aldose-1-phosphate adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55875", "l": "anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) <=> 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66469", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O => (17E)-cheilanthenediol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45803", "l": "15-demethylaclacinomycin T + AH2 + O2 <=> 10-decarboxymethylaclacinomycin T + A + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28103", "l": "GDP-alpha-D-mannose + H2O => D-mannose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65417", "l": "dGMP(in) + NAD(+)(out) => dGMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196857", "l": "PANK2 phosphorylates PanK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36839", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388900", "l": "Neurotensin receptors can bind neurotensins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984671", "l": "Chromokinesins form dimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031924", "l": "vitamin B6 transmembrane transporter activity", "d": ["Enables the transfer of any of the vitamin B6 compounds, pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56332", "l": "5'-triphosphoadenylyl-(2'->5')-adenosine + H2O = AMP + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19323", "l": "formaldehyde + N-methylaniline => N,N-dimethylaniline N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9733969", "l": "Bile salts dissociate from FABP6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63572", "l": "H2O + neurotensin-(1-8) = L-arginine + neurotensin-(1-7)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6795473", "l": "PDPK1 phosphorylates SGK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749977", "l": "UGT1A6 glucuronates ST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983158", "l": "Trimming of peptides in ER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427570", "l": "Group 3 - Selective Cl- transport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74734", "l": "Re-integration of insulin receptor into plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-500708", "l": "GRIK3 homomer binds glutamate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67311", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one <=> (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68643", "l": "(2E)-geranyl diphosphate <=> diphosphate + limonene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40156", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28063", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17922", "l": "D-arabinitol + NAD(+) => D-xylulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55142", "l": "AMP + D-alanyl-[D-alanyl-carrier protein] + H(+) => D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603784", "l": "PEX19:class I PMP binds PEX3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58473", "l": "2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 => CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68875", "l": "(E)-cinnamate + ATP + H(+) + NADPH <=> (E)-cinnamaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25401", "l": "(7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate => (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534096", "l": "METAP1/2 demethylates GNAT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24399", "l": "scytalone <=> 1,3,8-trihydroxynaphthalene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29804", "l": "ATP + H2O + L-valine(out) => ADP + H(+) + L-valine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944220", "l": "Association of procollagen type XXIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34423", "l": "(-)-secoisolariciresinol + NADP(+) = (+)-lariciresinol + H(+) + NADPH", "d": []}, {"i": "EC:1.23.1.2", "l": "\"(+)-lariciresinol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64270", "l": "emodin + H(+) + H2O => emodin anthrone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47426", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA => (2E,9Z)-octadecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847912", "l": "PNPLA7 hydrolyzes LysoPtdCho (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031759", "l": "Edg-6 sphingosine 1-phosphate receptor binding", "d": ["Binding to an Edg-6 sphingosine 1-phosphate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8931981", "l": "RUNX1 binds ESR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19440", "l": "nicotinate + UDP-alpha-D-glucose <=> N-(beta-D-glucosyl)nicotinate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35622", "l": "L-idarate <=> D-glucarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51724", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = adenosine 5'-tetraphosphate + ADP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52501", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022073", "l": "Procollagen triple helix formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49780", "l": "docosanoyl-CoA + glycine = CoA + H(+) + N-docosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936747", "l": "cleavage of L-cysteine from carrier protein (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60031", "l": "(2E)-geranyl diphosphate + H2O <=> 4-terpineol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793096", "l": "MRM3 (RNMTL1) methylates guanosine-1370 of 16S rRNA yielding 2'-O-methylguanosine-1370 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015345", "l": "ferric enterobactin:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74718", "l": "Internalisation of the insulin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199154", "l": "CD200 binds to CD200R (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75876", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55828", "l": "cortisol + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39121", "l": "(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2 => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25322", "l": "N-methylethanolamine phosphate + S-adenosyl-L-methionine => H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40446", "l": "6-deoxy-6-sulfo-D-fructose + ATP <=> 6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64132", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44168", "l": "dodecanoate + 2 H(+) + NADH = dodecanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49991", "l": "acetone + H(+) + NADPH + O2 <=> H2O + methyl acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709396", "l": "CO translocates from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49270", "l": "23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin] => 25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163798", "l": "Furin cleaves pro-protein Z to protein Z (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10746", "l": "3,4-dihydroxybenzoate + CO2 + NADH => (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57043", "l": "aldehydo-D-apiose <=> D-apiofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58533", "l": "15alpha-stemmadenine intermediate I + H2O => akuammicine + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24047", "l": "3,4-dihydroxybenzoate + O2 <=> 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19500", "l": "H(+) + L-aspartate <=> beta-alanine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018594", "l": "MECP2 binds LBR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67734", "l": "a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA => uridylyl-uridylyl-ribonucleotide-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35063", "l": "H2O + pyrazinamide = NH4(+) + pyrazine-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22921", "l": "L-glutamine + scyllo-inosose => 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17943", "l": "2-methyl-cis-aconitate + H2O => (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28227", "l": "(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878654", "l": "ACP6 hydrolyses MYS-LPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446322", "l": "PARVA associates with Paxillin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901515", "l": "poly-beta-1,6-N-acetyl-D-glucosamine transmembrane transporter activity", "d": ["Enables the transfer of poly-beta-1,6-N-acetyl-D-glucosamine from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250264", "l": "TXNIP binds reduced thioredoxin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15878", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate => D-glutamate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617652", "l": "HOXD3 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67524", "l": "4,8-dimethylnonanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43256", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15807", "l": "(4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate => (7R,8S)-7,8-diammoniononanoate + ATP + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59176", "l": "ADP + L-serine = AMP + H(+) + O-phospho-L-serine", "d": []}, {"i": "EC:2.7.1.226", "l": "\"L-serine kinase (ADP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13940", "l": "4-sulfobenzoate + NADH + O2 <=> 3,4-dihydroxybenzoate + NAD(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44776", "l": "2-demethylmenaquinol-6 + S-adenosyl-L-methionine = H(+) + menaquinol-6 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937369", "l": "ATAD2 binds ESR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58338", "l": "a 4-hydroxynonenal + H(+) + NADPH => a 4-hydroxynonen-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12159", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) <=> 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031687", "l": "A2A adenosine receptor binding", "d": ["Binding to an A2A adenosine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676229", "l": "WIPIs bind PI3P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404135", "l": "RBP4 binds atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48362", "l": "a 2-hydroxy fatty acid + H2O => a 1,2-saturated fatty acid + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450187", "l": "TAK1 is activated within the TAK1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727188", "l": "ATP4A:ATP4B binds PPIs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1461971", "l": "Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210294", "l": "Interaction of PECAM-1 and SHP-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046028", "l": "electron transporter, transferring electrons from cytochrome b6/f complex of photosystem II activity", "d": ["Enables the directed movement of electrons from the cytochrome b6/f complex of photosystem II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75147", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (-)-cyatha-3,12-diene + diphosphate", "d": []}, {"i": "EC:4.2.3.206", "l": "\"(-)-cyatha-3,12-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202692", "l": "PIP3 binds to RhoA and activates it (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46215", "l": "H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine <=> 4-amino-5-aminomethyl-2-methylpyrimidine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69788", "l": "(2-aminophenyl)succinate + succinyl-CoA => 3-(2-aminophenyl)succinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482772", "l": "Release of platelet cytosolic components (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12635", "l": "(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) => benzoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47133", "l": "11-cis-retinal + H2O + NAD(+) => 11-cis-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59316", "l": "D-cellobiose + O2 = D-cellobiono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004436", "l": "phosphatidylinositol diacylglycerol-lyase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "ic": "45.62324350230741", "identifiers": [{"i": "GO:0015075", "l": "monoatomic ion transmembrane transporter activity", "d": ["Enables the transfer of an ion from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39797", "l": "7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate => 7beta-hydroxycholesterol(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20683", "l": "H(+) + O-beta-D-glucosyl-cis-zeatin + UDP => cis-zeatin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34515", "l": "tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine = N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP", "d": []}, {"i": "EC:2.7.8.36", "l": "\"undecaprenyl phosphate N,N'-diacetylbacillosamine 1-phosphate transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44505", "l": "4-hydroxybenzoate + an all-trans-polyprenyl diphosphate => a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428909", "l": "Activated TP receptor binds G-protein  G13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870469", "l": "RGGT geranylgeranylates RAB proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39427", "l": "(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH = (23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693111", "l": "RHOF auto-activates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-209792", "l": "N-acetylation of serotonin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047716", "l": "imidazole N-acetyltransferase activity", "d": ["Catalysis of the reaction: 1H-imidazole + acetyl-CoA = N-acetylimidazole + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25910", "l": "an aldose + H2O2 => an alditol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446077", "l": "BP230 interacts with keretin K5/K14 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.37", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102499", "l": "SHG alpha-glucan phosphorylase activity", "d": ["Catalysis of the reaction: hydrogenphosphate + a plant soluble heteroglycan = alpha-D-glucose 1-phosphate + a plant soluble heteroglycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611721", "l": "β1-agonists bind ADRB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879907", "l": "Tyrosine kinases phosphorylate the receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47553", "l": "glycodeoxycholate + H2O => deoxycholate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65950", "l": "A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O => a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0140829", "l": "bicarbonate:monoatomic anion antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(in) + HCO3-(out) = solute(out) + HCO3-(in)."]}, {"i": "TCDB:2.A.31.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27946", "l": "dopamine + H2O + O2 = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34449", "l": "dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH => dTDP-6-deoxy-beta-L-talose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874078", "l": "PTK2 autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729260", "l": "GSK3 phosphorylates nucleoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5660660", "l": "p300 acetylates RELA subunit (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757256", "l": "MCM3 binds MCM5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23231", "l": "L-lysine + NADPH + O2 <=> H2O + N(6)-hydroxy-L-lysine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168301", "l": "Elongation, Polyadenylation and Termination (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23434", "l": "(4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140769", "l": "factor VII -> factor VIIa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0016682", "l": "oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen."]}, {"i": "EC:1.10.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13701", "l": "acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine", "d": []}, {"i": "EC:2.3.1.31", "l": "\"homoserine O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50523", "l": "acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847537", "l": "RAB43:GTP binds USP8NL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354124", "l": "Phosphorylation of pPTK2 by SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0016892", "l": "RNA endonuclease activity, producing 3'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679045", "l": "C-ter TLR9 dimer binds HCQ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23698", "l": "D-glucuronate + H(+) + H2O => myo-inositol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964274", "l": "G alpha (12) binds BTK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.84", "l": "\"limulus clotting factor C\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168885", "l": "Haptoglobin binds Hemoglobin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14224", "l": "H2O + monomethyl sulfate <=> H(+) + methanol + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46412", "l": "a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69974", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S)-22-hydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694522", "l": "Inner coat assembly and cargo binding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44298", "l": "4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61867", "l": "AH2 + dehydroprobetaenone I <=> A + probetaenone I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54929", "l": "3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17081", "l": "(E)-isoeugenol + S-adenosyl-L-methionine = (E)-isomethyleugenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71353", "l": "androsterone 3alpha-sulfate(in) + 2 Na(+)(in) => androsterone 3alpha-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46926", "l": "4-methylpent-2-enoyl-CoA + H2O => (R)-2-hydroxy-4-methylpentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0061594", "l": "6-deoxy-6-sulfofructose kinase activity", "d": ["Catalysis of the reaction 6-deoxy-6-sulfofructose + ATP = 6-deoxy-6-sulfofructose-1-phosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71165", "l": "H(+)(out) + L-alanine(in) + Na(+)(in) => H(+)(in) + L-alanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49038", "l": "(-)-bursehernin + H(+) + S-adenosyl-L-homocysteine => (-)-pluviatolide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13564", "l": "H2O + meso-2,6-diaminoheptanedioate + NADP(+) <=> (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61958", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31877", "l": "marneral => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69454", "l": "3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+) => 3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46014", "l": "a quinol + oxaloacetate => (S)-malate + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.28", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25537", "l": "ent-copalyl diphosphate => diphosphate + ent-sandaracopimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72100", "l": "Na(+)(out) + O-acetyl-(R)-carnitine(out) => Na(+)(in) + O-acetyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11639", "l": "NADP(+) + prostaglandin E1 <=> 15-oxoprostaglandin E1 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23453", "l": "2'-deoxyadenosine + ATP => ADP + dAMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730840", "l": "Activation of RAC1 by VAV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733292", "l": "AMY1-3 bind pramlintide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30643", "l": "phosphate + S-methyl-5'-thioinosine = hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}, {"i": "EC:2.4.2.44", "l": "\"S-methyl-5'-thioinosine phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41049", "l": "1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11976", "l": "anhydrotetracycline + H(+) + NADPH + O2 = 5a,11a-dehydrotetracycline + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.38", "l": "\"anhydrotetracycline 6-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173705", "l": "C5b binds C6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72456", "l": "fumarate(out) + 3 H(+)(out) => fumarate(in) + 3 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56451", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797961", "l": "CHDH oxidises Cho to BETALD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16538", "l": "(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O => (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16362", "l": "2-acetolactate => 3-hydroxy-3-methyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47322", "l": "3-oxo-3-phenylpropanoate + L-glutamate => (S)-3-amino-3-phenylpropanoate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.-.-", "l": "\"Other oxidoreductases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.35", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58409", "l": "NADP(+) + undecan-1-ol => H(+) + NADPH + undecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63965", "l": "sphinga-4E,14Z-dienine-1-phosphate => (2E,12Z)-hexadecadienal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34632", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0070990", "l": "snRNP binding", "d": ["Binding to a small nuclear ribonucleoprotein particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952069", "l": "HDAC4 deacetylates RUNX3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647994", "l": "RAS proteins are depalmitoylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199203", "l": "PANK1/3/4 phosphorylate PanK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12641", "l": "(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.95", "l": "\"phosphoglycerate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76466", "l": "CYP4A11 12-hydroxylates DDCX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57475", "l": "(E)-4-coumarate + UDP-alpha-D-glucose <=> 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048027", "l": "mRNA 5'-UTR binding", "d": ["Binding to an mRNA molecule at its 5' untranslated region."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21011", "l": "diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) <=> diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20969", "l": "L-arabinonate => 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51348", "l": "acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine = 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0050321", "l": "tau-protein kinase activity", "d": ["Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22595", "l": "(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate <=> (9S,13S,15Z)-12-oxophyto-10-15-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2750177", "l": "Syndecan-2 binds TRAPPC4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38329", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56406", "l": "(3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+) => [(3R)-hydroxybutanoate](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40831", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33271", "l": "a triacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855648", "l": "SALM3 binds LAR-RPTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635839", "l": "ULK3:SUFU dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14381", "l": "4-guanidinobutanal + H2O + NAD(+) = 4-guanidinobutanoate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.54", "l": "\"gamma-guanidinobutyraldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.68", "l": "\"isoamylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54928", "l": "3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64596", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.370", "l": "\"inositol phosphorylceramide mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65788", "l": "diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49152", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine = dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46216", "l": "H(+) + NADPH + progesterone = 3beta-hydroxypregn-4-ene-20-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140806", "l": "SERPINC1 binds SERPINC1 activators (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050351", "l": "trimetaphosphatase activity", "d": ["Catalysis of the reaction: H2O + trimetaphosphate = 2 H+ + triphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002056", "l": "cytosine binding", "d": ["Binding to cytosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69416", "l": "H(+) + H2O2 + thiocyanate = H2O + hypothiocyanous acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2152276", "l": "Secretion of transmembrane collagens (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51065", "l": "3'-phosphoadenylyl sulfate + lithocholate => adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428750", "l": "Gq activation by TP receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1011598", "l": "DOCKs bind to RhoGEFs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73781", "l": "diphosphate + tardioxopiperazine A => dimethylallyl diphosphate + preechinulin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140679", "l": "ABC-type sodium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na(in) -> ADP + phosphate + Na(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.35", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42753", "l": "pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48447", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol <=> a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.15", "l": "\"anhydrosialidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047916", "l": "GDP-6-deoxy-D-talose 4-dehydrogenase activity", "d": ["Catalysis of the reaction: GDP-6-deoxy-D-talose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-talose + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332356", "l": "CAMK2 binds MAP3K7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52075", "l": "12-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75125", "l": "acetate + 2 H(+) + phosphate => (1R)-(1-hydroxyethyl)phosphonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52015", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA <=> 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008127", "l": "quercetin 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: H+ + O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62757", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23218", "l": "3-hydroxybenzoyl-CoA + H2O + NADP(+) => benzoyl-CoA + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35525", "l": "N-ethylsuccinimide + NADP(+) => H(+) + N-ethylmaleimide + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44606", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6794347", "l": "Homer1,2,3 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014449", "l": "RHOG binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59094", "l": "[(1->3)-alpha-D-glucosyl](n+1) + D-fructose => [(1->3)-alpha-D-glucosyl](n) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53961", "l": "4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 => 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36465", "l": "glycine + L-glutamate => glycyl-L-glutamate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58383", "l": "NADP(+) + nonan-1-ol <=> H(+) + NADPH + nonanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35299", "l": "3-hydroxyoctadecanoyl-CoA + NADP(+) = 3-oxooctadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52880", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873918", "l": "Transphosphorylation of JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000074", "l": "TCN2 binds RCbl in the circulation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59570", "l": "ADP + H(+) + L-homocarnosine + phosphate => 4-aminobutanoate + ATP + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34057", "l": "6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH => festuclavine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9017491", "l": "RHOJ GEFs activate RHOJ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12695", "l": "3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+) => 3,4-dihydroxypyridine + O-acetyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682709", "l": "LGI4 binds ADAM22,23,11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46647", "l": "cortisol + H(+) + NADPH <=> 5beta-dihydrocortisol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350901", "l": "Iodide is organified (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46909", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11613", "l": "H2O + L-glutamate + NADP(+) => 2-oxoglutarate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58985", "l": "acrolein + H2O + O2 => acrylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69338", "l": "(Z)-alkanethial oxide => (E)-alk-1-en-1-SO-peroxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025007", "l": "Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32233", "l": "ADP + H(+) + NADPH + phosphate => (6S)-NADPHX + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68807", "l": "H2O + kojibiose <=> alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592278", "l": "Autocatalytic activation of proMMP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667619", "l": "AVPR1A,B,2 bind atosiban (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22712", "l": "adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate", "d": []}, {"i": "EC:2.7.7.62", "l": "\"adenosylcobinamide-phosphate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29187", "l": "succinate + ubiquinone-8 = fumarate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27696", "l": "(S)-3-methyl-2-oxopentanoate + H2O => (2R,3R)-2,3-dihydroxy-3-methylpentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74733", "l": "Insulin receptor de-phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418451", "l": "cGMP stimulates Protein Kinase G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750226", "l": "NLRC5 binds IKBKB and CHUK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13775", "l": "(S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48968", "l": "[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 = [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9716913", "l": "ESR1 binds ESR1 antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757688", "l": "SERPINA6 binds PREDN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388828", "l": "PD-1 binds B7DC and B7H1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32979", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = a fatty acid + H(+) + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51033", "l": "7-chloroindole-3-pyruvate imine dimer => dichlorochromopyrrolate + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018766", "l": "dihydrophloroglucinol hydrolase activity", "d": ["Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362437", "l": "C-terminal Hh fragments are bound by lectins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047535", "l": "2-alkyn-1-ol dehydrogenase activity", "d": ["Catalysis of the reaction: 2-butyne-1,4-diol + NAD+ = 4-hydroxy-2-butynal + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102686", "l": "UDP-glucose:trans-zeatin 9-N-glucosyltransferase", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose(2-) + trans-zeatin <=> H+ + 9-(alpha-D-glucosyl)-trans-zeatin + UDP(3-)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070412", "l": "R-SMAD binding", "d": ["Binding to a receptor-regulated SMAD signaling protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33719", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203611", "l": "N-myristoylation of eNOS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964274", "l": "G alpha (12) binds BTK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53991", "l": "H2O + O-phospho-L-threonyl-[myosin light chain] <=> L-threonyl-[myosin light chain] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45332", "l": "7,8-dihydroneopterin + O2 = 7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+)", "d": []}, {"i": "EC:1.13.11.81", "l": "\"7,8-dihydroneopterin oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050437", "l": "(-)-endo-fenchol synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + H2O = (-)-endo-fenchol + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667456", "l": "AVPR1A,B bind desmopressin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21157", "l": "(2R)-2-phosphoglycerate + H2O => (R)-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928639", "l": "p-EFNB binds GRB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70937", "l": "L-lysine(out) => L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40695", "l": "1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol = 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22825", "l": "2'-deoxyuridine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9724685", "l": "IgE binds omalizumab (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39421", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418872", "l": "Phosphorylation of FADK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32467", "l": "2 S-adenosyl-L-methionine + sarcosine = glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.157", "l": "\"sarcosine/dimethylglycine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879724", "l": "Expression of PPARA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645428", "l": "ALPK1 binds ADP-heptose (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72101", "l": "Na(+)(in) + O-acetyl-(R)-carnitine(in) => Na(+)(out) + O-acetyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15430", "l": "heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69152", "l": "Removal of remaining Flap (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211968", "l": "CYP2W1 oxidises INDOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67268", "l": "(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate = sch 210972", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61992", "l": "N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39362", "l": "(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37633", "l": "1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26184", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59464", "l": "NADP(+) + octadecan-1-ol = H(+) + NADPH + octadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005137", "l": "interleukin-5 receptor binding", "d": ["Binding to an interleukin-5 receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034936", "l": "4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 4,6-dichloro-3-methylcatechol + O2 = 3,5-dichloro-3-methyl-cis,cis-muconate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731141", "l": "Syndecan-1 binds fibronectin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839634", "l": "CTNNB1 S33 mutants aren't phosphorylated by GSK3beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218806", "l": "FYN autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047620", "l": "acylglycerol kinase activity", "d": ["Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18778", "l": "an alkylmercury + H(+) => an alkane + Hg(2+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15280", "l": "acetyl-CoA + L-lysyl-[alpha-tubulin] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865320", "l": "CBFB binds RUNX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0042947", "l": "glucoside transmembrane transporter activity", "d": ["Enables the transfer of glucosides from one side of a membrane to the other. Glucosides are glycosides in which the sugar group is a glucose residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35307", "l": "H(+) + NADH + O2 + salicylate = 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.172", "l": "\"salicylate 5-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35275", "l": "3-hydroxyoctadecanoyl-CoA + NAD(+) = 3-oxooctadecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186765", "l": "PLC-gamma binds to the active receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16331", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18021", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379861", "l": "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.119", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.35", "l": "\"dimethylsulfone monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63136", "l": "adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione = cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-adenosylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14658", "l": "aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57543", "l": "a 5'-end NTP-ribonucleotide-RNA + H2O <=> a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694522", "l": "Inner coat assembly and cargo binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56158", "l": "(12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70481", "l": "TPI1 isomerizes GA3P to DHAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592362", "l": "Activation of proMMP7 by MMP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50894", "l": "a menaquinol + thiosulfate => a menaquinone + 2 H(+) + hydrogen sulfide + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964773", "l": "OXGR1 binds 2OG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38960", "l": "a 2,3-saturated acyl-CoA + O2 => a (2E)-enoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63004", "l": "(11Z,14Z)-eicosadienamide + H2O = (11Z,14Z)-eicosadienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21205", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol => a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26400", "l": "all-trans-zeaxanthin + 2 O2 <=> 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351849", "l": "Caspase-mediated cleavage of Etk (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39368", "l": "(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH => (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005007", "l": "fibroblast growth factor receptor activity", "d": ["Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47074", "l": "eicosanoate + glycerol + H(+) => 1-eicosanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061797", "l": "pH-gated chloride channel activity", "d": ["A gated channel activity that enables the transmembrane transfer of a chloride ion by a channel that opens in response to a change in pH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015330", "l": "high-affinity glutamine transmembrane transporter activity", "d": ["Enables the transfer of glutamine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29482", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-epicubenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68862", "l": "7beta-25-dihydroxycholesterol + NADP(+) => 7-oxo-25-hydroxycholesterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847880", "l": "CYTH proteins bind ARF1:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.176", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190519", "l": "Internalization of gap junction plaques (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.98", "l": "\"hepacivirin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14869", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74733", "l": "Insulin receptor de-phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18297", "l": "a phtalamide + H2O = a primary amine + phthalate", "d": []}, {"i": "EC:3.5.1.79", "l": "\"phthalyl amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043738", "l": "reduced coenzyme F420 dehydrogenase activity", "d": ["Catalysis of the reaction: methanophenazine + reduced coenzyme F420 = dihydromethanophenazine + coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73882", "l": "histamine(out) <=> histamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50459", "l": "prostaglandin H3 <=> prostaglandin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14439", "l": "6-amino-2-oxohexanoate + H2O2 + NH4(+) => H2O + L-lysine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909738", "l": "SHP1 and SHP2 bind the common beta chain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58062", "l": "acetaldehyde + H(+) + sulfite => 2-sulfinoacetaldehyde + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433501", "l": "Interaction of other adapter proteins with p-KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54116", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + pseudolaratriene", "d": []}, {"i": "EC:4.2.3.180", "l": "\"pseudolaratriene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20554", "l": "(R)-methylmalonyl-CoA => (S)-methylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23024", "l": "[(1->4)-beta-D-glucosyl](n) + phosphate = [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}, {"i": "EC:2.4.1.49", "l": "\"cellodextrin phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043880", "l": "crotonyl-CoA reductase activity", "d": ["Catalysis of the reduction of crotonyl-CoA to butyryl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69314", "l": "benzyl thiocyanate + sulfate => (Z)-phenyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71331", "l": "chloride(out) + L-phenylalanine(out) + 2 Na(+)(out) = chloride(in) + L-phenylalanine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30548", "l": "(3S)-hydroxyhexanoyl-CoA => (2E)-hexenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955844", "l": "RBKS phosphorylates ribose to R5P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31055", "l": "estrone 3-sulfate + H2O = estrone + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22818", "l": "alpha-D-xylulofuranose => alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507869", "l": "Aquaporins passively transport glycerol into cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61385", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373738", "l": "Neurofascin interacts with syntenin-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57153", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 => (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44360", "l": "(2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate", "d": []}, {"i": "EC:5.3.1.32", "l": "\"(4S)-4-hydroxy-5-phosphooxypentane-2,3-dione isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592436", "l": "Initial activation of proMMP9 by MMPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58719", "l": "FADH2-C4alpha-hydroperoxide + NADH + rifampicin <=> FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55770", "l": "all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP => all-trans-retinoate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65825", "l": "dec-9-enoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => dec-9-ynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56195", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211219", "l": "Translocation of caspase-3 to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.824318789188837", "identifiers": [{"i": "GO:0015171", "l": "amino acid transmembrane transporter activity", "d": ["Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163310", "l": "TFAM binds to mitochondrial promoters (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59302", "l": "adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+) => 3'-phosphoadenylyl sulfate + firefly D-luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693347", "l": "HTR1A binds 5HT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72317", "l": "glutathione(out) + leukotriene C4(in) => glutathione(in) + leukotriene C4(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62641", "l": "[mycoredoxin]-L-dithiol + a hydroperoxide => [mycoredoxin]-L-disulfide + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53810", "l": "(24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholestanol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17548", "l": "[protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] <=> [protein]-disulfide + ADP + phosphate + S-hydroxy-L-cysteinyl-[peroxiredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052628", "l": "4-hydroxybenzoate amino acid synthetase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + ATP + amino acid = 4-hydroxybenzoyl amino acid conjugate + AMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32438", "l": "dihydrocarvone + H(+) + NADPH + O2 <=> 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690461", "l": "FKBP1A binds tacrolimus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072371", "l": "histone H2AS121 kinase activity", "d": ["Catalysis of the reaction: histone H2A-serine (position 121) + ATP = histone H2A-phosphoserine (position 121) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 121 of histone H2A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52281", "l": "(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37607", "l": "(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16880", "l": "3-sulfino-L-alanine + H(+) <=> CO2 + hypotaurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19940", "l": "glycine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800035", "l": "IGFBP3 binds TMEM219 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088205", "l": "Plasma membrane glycoconjugates translocate to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60780", "l": "2-oxoglutarate + gibberellin A15 + O2 = CO2 + gibberellin A24 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0005231", "l": "excitatory extracellular ligand-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004486", "l": "methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029155", "l": "JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45605", "l": "D-glucaro-1,4-lactone => 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211224", "l": "Association of DFF40 with DFF45 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30804", "l": "4-aminobutanal + H2O + NADP(+) => 4-aminobutanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60404", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209921", "l": "Monoiodinated tyrosine can be deiodinated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25571", "l": "ATP + beta-D-ribosylnicotinate <=> ADP + H(+) + nicotinate beta-D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57323", "l": "acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] <=> CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102432", "l": "quercetin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine <=> rhamnetin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50463", "l": "a medium chain fatty acid + ATP + holo-[ACP] <=> a medium-chain fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15233", "l": "Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite", "d": []}, {"i": "EC:1.7.2.1", "l": "\"nitrite reductase (NO-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73718", "l": "UBF-1 Binds rDNA Promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9663511", "l": "BIL binds GSTA1, FABP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63799", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31324", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48379", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose <=> a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65843", "l": "ATP(out) + Mg(2+)(out) + phosphate(in) <=> ATP(in) + Mg(2+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621048", "l": "TPH1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68974", "l": "AH2 + dihydroxyacetone phosphate => A + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70427", "l": "H2O + phenylacetyl-CoA = 2-phenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37071", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10082", "l": "1,3,5-trihydroxybenzene + NADPH => dihydrophloroglucinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68936", "l": "ATP + H(+) + NADPH + nonanoate = AMP + diphosphate + NADP(+) + nonanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57448", "l": "ATP + D-tyrosine + tRNA(Tyr) = AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192061", "l": "CYP46A1 24-hydroxylates CHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793472", "l": "RIPK3 binds p-S9-PRKN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0008242", "l": "omega peptidase activity", "d": ["Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690873", "l": "ACO1 binds 4Fe-4S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975880", "l": "MyD88 oligomerization within the complex of activated TLR:MyD88 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018754", "l": "ammelide aminohydrolase activity", "d": ["Catalysis of the reaction: ammelide + H2O = cyanuric acid + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0051717", "l": "inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71455", "l": "goralatide + H2O = L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43014", "l": "2-aminobut-2-enoate + H(+) + hydrogen sulfide => L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008577", "l": "IL37:IL18R1 binds SIGIRR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937864", "l": "RUNX2 binds tyrosine phosphorylated YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55878", "l": "apo-[aequorin]--coelenterazine => apo-[aequorin] + coelenterazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9006850", "l": "IL21 receptor JAK phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69886", "l": "L-ascorbate(out) + 2 Na(+)(out) <=> L-ascorbate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190682", "l": "Connexin synthesis (generic) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49497", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+) => 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61906", "l": "H2O + NADP(+) + stemphyloxin II => betaenone A + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218906", "l": "RIPK3 phosphorylates MLKL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31730", "l": "FADH2 + O2 + styrene <=> (2S)-2-phenyloxirane + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769141", "l": "NPAS4 translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419426", "l": "Cannabinoid receptors can bind cannabinoids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191636", "l": "Phosphorylation of Cx43 by c-src (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18401", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.37", "l": "\"4-hydroxyphenylacetaldehyde oxime monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190065", "l": "Activated TrkA receptor internalizes to endosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928607", "l": "p-EPHs bind VAV2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66812", "l": "5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH = 8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46962", "l": "(2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36772", "l": "beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72704", "l": "UDP-alpha-D-galactose(in) + UMP(out) => UDP-alpha-D-galactose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247841", "l": "PLCG1 binds to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35427", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside = (E)-sinapate + cyanidin 3,5-di-O-beta-D-glucoside", "d": []}, {"i": "EC:2.4.1.299", "l": "\"cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18143", "l": "2-hydroxycyclohexan-1-one + H(+) + NADH => NAD(+) + trans-cyclohexane-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58507", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate <=> (3Z)-2-oxo-4-carboxy-3-hexenedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981610", "l": "Neuroglobin binds oxygen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804379", "l": "PRMT5 binds TTC5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25626", "l": "H2O + histamine + O2 => H2O2 + imidazole-4-acetaldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549322", "l": "OCT1 transports organic cations out of hepatic cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.12", "l": "\"nepenthesin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29492", "l": "(2E,6E)-farnesyl diphosphate => cis-muurola-4(14),5-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16384", "l": "L-arabinitol + NAD(+) <=> H(+) + L-xylulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140837", "l": "RNA polymerase II CTD heptapeptide repeat S7 kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 7)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5195402", "l": "CDK1 phosphorylates LPIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37627", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102583", "l": "cyanidin 3-O-glucoside-(2''-O-xyloside) 6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-sambubioside + 4-coumaryl-CoA <=> cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-915148", "l": "Correctly folded glycoproteins translocate to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53601", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72698", "l": "UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) <=> UDP-N-acetyl-alpha-D-glucosamine(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047217", "l": "sucrose-1,6-alpha-glucan 3(6)-alpha-glucosyltransferase activity", "d": ["Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = 1,6-alpha-D-glucosyl(n+1) + fructose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948775", "l": "MKRN1 polyubiquitinates PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67236", "l": "mycophenolyl-CoA + propanoyl-CoA = (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24094", "l": "2 (2S)-bisdechlorogeodin + 2 H2O => 2 H(+) + O2 + 2 sulochrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70272", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53895", "l": "an S-prenyl-L-cysteine + H2O + O2 <=> a prenal + H2O2 + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69354", "l": "H2O + thiosulfinate => 2 (E)-prop-1-en-1-SO-peroxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534378", "l": "Hv1 Mediated H+ Permeability (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48927", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E)) <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23489", "l": "1,4-benzoquinone + H(+) + NADPH => hydroquinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800793", "l": "PIDD1 translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0042294", "l": "URM1 transferase activity", "d": ["Catalysis of the transfer of URM1 from one protein to another via the reaction X-URM1 + Y = Y-URM1 + X, where both X-URM1 and Y-URM1 are covalent linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619783", "l": "CAMK1 phosphorylates ARHGEF7-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21266", "l": "AH2 + glyoxylate => A + glycolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44580", "l": "4-hydroxy-3-all-trans-decaprenylbenzoate + H(+) = 2-all-trans-decaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036077", "l": "Defective HYAL1 does not hydrolyse (HA)50 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.22", "l": "\"stromelysin 2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53273", "l": "5-dehydro-L-gluconate => keto-D-tagaturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50517", "l": "acetyl-CoA + N-terminal L-threonyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23092", "l": "H(+) + H2O + hydroxyatrazine = ethylamine + N-isopropylammelide", "d": []}, {"i": "EC:3.5.4.43", "l": "\"hydroxydechloroatrazine ethylaminohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63738", "l": "2-phenylethanol + NADP(+) => 2-phenylacetaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354077", "l": "Integrin alphaIIb beta3 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.57", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093342", "l": "SDC2 multimerises (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36844", "l": "(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62222", "l": "neopatulin => phyllostine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691131", "l": "CANDI binds CUL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23452", "l": "2'-deoxyadenosine + ATP = ADP + dAMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15947", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] => aldehydo-D-glucose 6-phosphate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2470483", "l": "Activin AB,B binds Activin Receptor ACVR2A,B:ACVR1C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043183", "l": "vascular endothelial growth factor receptor 1 binding", "d": ["Binding to a vascular endothelial growth factor receptor 1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55204", "l": "5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)", "d": []}, {"i": "EC:4.3.1.32", "l": "\"7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31012", "l": "(S)-2,3-epoxysqualene => camelliol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59596", "l": "H2O + kynuramine + O2 = 3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46892", "l": "2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate = 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate", "d": []}, {"i": "EC:2.6.1.109", "l": "\"8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20896", "l": "ATP + hydrogencarbonate + urea = ADP + H(+) + phosphate + urea-1-carboxylate", "d": []}, {"i": "EC:6.3.4.6", "l": "\"urea carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0032550", "l": "purine ribonucleoside binding", "d": ["Binding to a purine ribonucleoside, a compound consisting of a purine base linked to ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58282", "l": "cyclic tetraadenylate + 4 diphosphate => 4 ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32573", "l": "2-methylisoborneol + diphosphate => (E)-2-methylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668714", "l": "RAC1:GTP binds NOX1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222722", "l": "Mycobactin is exported (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67400", "l": "(2E,6E)-farnesyl diphosphate = allo-aromadendrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202375", "l": "Recruitment of ITK to SLP-76 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082356", "l": "HSF1-mediated gene expression (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18817", "l": "acetyl-CoA + malonate = acetate + malonyl-CoA", "d": []}, {"i": "EC:2.8.3.3", "l": "\"malonate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19196", "l": "A + all-trans-13,14-dihydroretinol <=> AH2 + all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14845", "l": "L-aspartate 4-semialdehyde + pyruvate = (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661446", "l": "BMG, BDG translocates from ER lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18150", "l": "H2O + N-acetyl-D-galactosamine 6-phosphate => acetate + D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11610", "l": "[(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74842", "l": "UDP(in) + UDP-alpha-D-glucuronate(out) <=> UDP(out) + UDP-alpha-D-glucuronate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73674", "l": "ADP(out) + diphosphate(in) <=> ADP(in) + diphosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43907", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol <=> all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33540", "l": "ergosteryl ester + H2O => a carboxylate + ergosterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72371", "l": "dehydroepiandrosterone 3-sulfate(out) + succinate(in) = dehydroepiandrosterone 3-sulfate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192677", "l": "Newly synthesized vRNP for export (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200646", "l": "Cytosolic folate export across the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12043", "l": "(S)-3-(imidazol-5-yl)lactate + NADP(+) <=> 3-(imidazol-5-yl)pyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005274", "l": "allantoin:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804194", "l": "PRDM1 binds the TP53 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25972", "l": "H2O + N(8)-acetylspermidine + O2 = 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71471", "l": "H2O + substance P = L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63776", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12962", "l": "acetoacetate + butanoyl-CoA => acetoacetyl-CoA + butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50825", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 => 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41018", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol <=> 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847534", "l": "RAB43 hydrolyses GTP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44221", "l": "15-hydroxypentadecanoate + ATP + CoA => 15-hydroxypentadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48432", "l": "ATP + N(6)-D-ribulosyl-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41247", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47723", "l": "H(+) + H2O + isoguanine <=> NH4(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2168886", "l": "Hemopexin binds Hemes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44652", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51222", "l": "2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080118", "l": "brassinosteroid sulfotransferase activity", "d": ["Catalysis of the reaction: a brassinosteroid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated brassinosteroid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a brassinosteroid acceptor, producing the sulfated brassinosteroid derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21968", "l": "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate", "d": []}, {"i": "EC:4.2.3.4", "l": "\"3-dehydroquinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855232", "l": "RELN:VLDLR binds DAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5195402", "l": "CDK1 phosphorylates LPIN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32799", "l": "urea(in) = urea(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62010", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63810", "l": "AMP + diphosphate + H(+) + N(8)-citryl-spermidine => ATP + citrate + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34521", "l": "[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP => N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353430", "l": "Binding of Pol eta to a DNA template containing a lesion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24487", "l": "NAD(+) + sulcatol <=> H(+) + NADH + sulcatone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52264", "l": "3-(aminomethyl)indole + 2 S-adenosyl-L-methionine = gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.340", "l": "\"3-aminomethylindole N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047615", "l": "actinomycin lactonase activity", "d": ["Catalysis of the reaction: actinomycin + H2O = actinomycinic monolactone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.6", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0000829", "l": "inositol heptakisphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624611", "l": "FOXO1,FOXO3,(FOXO4) bind FBXO32 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51022", "l": "an aldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+) => a primary alcohol + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33878", "l": "cholesteryl (9Z-octadecenoate) + H2O <=> (9Z)-octadecenoate + cholesterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62983", "l": "(9Z)-hexadecenamide + H2O <=> (9Z)-hexadecenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432067", "l": "Aquaporin-4 passively transports water out of cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30944", "l": "FAD + H(+) + octanoyl-CoA => (2E)-octenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68848", "l": "(2Z,6E)-farnesyl diphosphate = diphosphate + gamma-cadinene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18708", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102308", "l": "erythromycin D 3''-o-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + erythromycin D <=> S-adenosyl-L-homocysteine + erythromycin B + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12953", "l": "ATP + L-seryl-[Goodpasture antigen-binding protein] = ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73301", "l": "(S)-malate(in) + H(+)(out) + phosphate(out) => (S)-malate(out) + H(+)(in) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57659", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b <=> CMP + ganglioside GT1balpha + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944263", "l": "Association of procollagen type II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.945916858897462", "identifiers": [{"i": "GO:0008443", "l": "phosphofructokinase activity", "d": ["Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33583", "l": "L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate = 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate", "d": []}, {"i": "EC:2.6.1.98", "l": "\"UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.1.22", "l": "\"4-hydroxyproline betaine 2-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419490", "l": "Binding of ATP to P2X receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944254", "l": "Association of procollagen type XXVI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74192", "l": "carbofuran + H(+) + H2O => 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-ol + CO2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001850", "l": "complement component C3a binding", "d": ["Binding to a C3a product of the complement cascade."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2248891", "l": "Active ARSA translocates to the lysosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12338", "l": "fumarate + glycolate => carboxymethoxysuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64088", "l": "acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA = 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-156930", "l": "GTP-binding activates eEF2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62970", "l": "H(+) + NADPH + pyruvate => (R)-lactate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16671", "l": "H(+) + NADH + urate => H2O + NAD(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9754130", "l": "CDK4 inhibitors bind CDK4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24440", "l": "ATP + H2O + phosphate(out) = ADP + H(+) + 2 phosphate(in)", "d": []}, {"i": "EC:7.3.2.1", "l": "\"ABC-type phosphate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045303", "l": "diaminobutyrate-2-oxoglutarate transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-2,4-diaminobutyrate = L-aspartate 4-semialdehyde + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047682", "l": "aryl-alcohol oxidase activity", "d": ["Catalysis of the reaction: an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047669", "l": "amylosucrase activity", "d": ["Catalysis of the reaction: sucrose + 1,4-alpha-D-glucosyl(n) = D-fructose + 1,4-alpha-D-glucosyl(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64566", "l": "ilicicolin H => 8-epi-ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69881", "l": "castasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6alpha-hydroxycastasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.159", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17471", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein] => a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50461", "l": "a medium chain fatty acid + ATP + holo-[ACP] => a medium-chain fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66100", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine = H2O + kynurenate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.112", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031761", "l": "fMet-Leu-Phe receptor binding", "d": ["Binding to a fMet-Leu-Phe receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102051", "l": "indole-3-acetyl-tryptophan synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-tryptophan + ATP(4-) <=> H+ + indole-3-acetyl-tryptophan + AMP(2-) + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34086", "l": "a (3R)-3-hydroxyacyl-CoA <=> a (3S)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40271", "l": "O2 + tetradecanedioyl-CoA = (2E)-tetradecenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69142", "l": "Recruitment of Dna2 endonuclease (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615829", "l": "IRAK1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432164", "l": "Ca2+ influx into the post-synaptic cell (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49296", "l": "keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + L-sorbose 1-phosphate(in)", "d": []}, {"i": "EC:2.7.1.206", "l": "\"protein-N(pi)-phosphohistidine--L-sorbose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008823", "l": "cupric reductase activity", "d": ["Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047044", "l": "androstan-3-alpha,17-beta-diol dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22182", "l": "(S)-norcodamine + H(+) + S-adenosyl-L-homocysteine => (S)-norreticuline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018627", "l": "2-aminobenzenesulfonate 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H+ + NADH + O2 = 2,3-dihydroxybenzenesulfonate + NAD+ + NH4. 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879925", "l": "SHC1 bound to the common beta chain becomes tyrosine phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.19", "l": "\"cyclomaltodextrin glucanotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38444", "l": "a fatty acyl-CoA + a long chain fatty alcohol => a wax ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27612", "l": "CO2 + H2 => formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785213", "l": "LIPC dimer binds heparin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15467", "l": "ADP + H(+) + sphinganine 1-phosphate => ATP + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19750", "l": "[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9035227", "l": "TXN2 binds CysS248-MPST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672011", "l": "p-AMPK:AMP binds the ULK complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6813749", "l": "ALDH1A1 oxidises GA to DGA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047191", "l": "1-alkylglycerophosphocholine O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42255", "l": "H(+) + malonyl-[ACP] + pentanoyl-CoA <=> 3-oxoheptanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018747", "l": "RHOQ GEFs activate RHOQ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2186771", "l": "RNF111 binds SMAD7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.10.-", "l": "\"Protein-tyrosine kinases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50707", "l": "1-propanol + NAD(+) <=> H(+) + NADH + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928619", "l": "PAK1 binds RAC1:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74707", "l": "Binding of IRS to insulin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.98.5", "l": "\"tetraether lipid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186765", "l": "PLC-gamma binds to the active receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62016", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.2.63", "l": "\"EGF-domain serine xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682111", "l": "Defective ABCA1 does not transport CHOL from transport vesicle membrane to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015193", "l": "L-proline transmembrane transporter activity", "d": ["Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid."]}, {"i": "REACT:R-HSA-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12955", "l": "ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein] => ATP + L-seryl-[Goodpasture antigen-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805399", "l": "TAF1 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59486", "l": "arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+) => arsenite + 2 Fe(III)-[cytochrome c] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69578", "l": "(R)-N6-(S8-glutaryldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2 => (R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoadipate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59462", "l": "H(+) + hexadecanal + NADPH => hexadecan-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62027", "l": "campesteryl 3-beta-D-glucoside + H2O <=> campesterol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69990", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + NADP(+) <=> (22S)-22-hydroxycampest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106240", "l": "labd-13Z-ene-9,15,16-triol synthase activity", "d": ["Catalysis of the reaction:O2 + peregrinol + reduced [NADPH--hemoprotein reductase] = H+ + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]."]}, {"i": "RHEA:62192", "l": "O2 + peregrinol + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72026", "l": "nicotinate(in) + urate(out) <=> nicotinate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60098", "l": "3-dehydro-4alpha-methylzymosterol + CO2 + NADPH => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664991", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047022", "l": "7-beta-hydroxysteroid dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + a 7-beta-hydroxysteroid = NADPH + H+ + a 7-oxosteroid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2534365", "l": "Slo3 Potassium Transport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34837", "l": "a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13372", "l": "dimethylallyl diphosphate <=> diphosphate + isoprene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690449", "l": "S1PR1 bind S1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65768", "l": "a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.38", "l": "\"N,N-dimethyl phenylurea N-demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34651", "l": "3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine = 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174446", "l": "Removal of remaining Flap from the C-strand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018756", "l": "RHOH binds GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40567", "l": "AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 = A + dTDP-beta-L-evernitrose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67820", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59565", "l": "H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone => H(+) + N,N',N'',N'''-tetraacetylchitotetraonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176942", "l": "Multiple proteins are localized at replication fork (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56439", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55441", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39271", "l": "(3R)-hydroxy-(15Z)-tetracosenoyl-CoA = (2E,15Z)-tetracosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70899", "l": "histidine => urocanate + NH4+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684052", "l": "PIAS4 SUMOylates MDC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35392", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA => (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67657", "l": "2 Fe(III)-[cytochrome c] + NADPH => 2 Fe(II)-[cytochrome c] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27884", "l": "3'-CMP + H(+) => 2',3'-cyclophospho-CMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63320", "l": "a glycerophospholipid(in) + ATP + H2O = a glycerophospholipid(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106076", "l": "peptide-lysine-N-succinyltransferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + lysine in peptide = CoA + N-succinyl-lysine-peptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72672", "l": "The 60S subunit joins the translation initiation complex  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51911", "l": "dATP + H2O <=> dADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56043", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16500", "l": "adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63089", "l": "a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.3", "l": "\"phosphoserine phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211164", "l": "AKT phosphorylates FOXO1A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814088", "l": "SYS1 binds AcM-ARFRP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211874", "l": "CYP2S1 4-hydroxylates atRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72291", "l": "2,3-dimethylsuccinate(out) + 3 Na(+)(out) = 2,3-dimethylsuccinate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53079", "l": "cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031771", "l": "type 1 orexin receptor binding", "d": ["Binding to a type 1 orexin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39035", "l": "an omega-hydroxy fatty acid + NAD(+) = an omega-oxo fatty acid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38044", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085992", "l": "SUMOylation of DAXX with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38584", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35600", "l": "NADP(+) + propane-1,3-diol => 3-hydroxypropanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592436", "l": "Initial activation of proMMP9 by MMPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797810", "l": "PTPRD binds IL1RAPL1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52238", "l": "3 A + Fe(2+) + 3 H2O + mycobilin b => 3 AH2 + 2 H(+) + heme b + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21629", "l": "17alpha-hydroxyprogesterone + NADPH + O2 => acetate + androst-4-ene-3,17-dione + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164834", "l": "Enzyme-bound ATP is released (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19011", "l": "a carboxylate + H(+) + pyruvate => a 3-acylpyruvate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.7", "l": "\"interstitial collagenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28089", "l": "2 H2O2 + Reactive Blue 5 <=> 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247849", "l": "WLS dissociates from retromer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67998", "l": "A + chloride + chloroethene + H(+) => (Z)-1,2-dichloroethene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20328", "l": "N-hydroxy-4-acetylaminobiphenyl <=> N-acetoxy-4-aminobiphenyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35083", "l": "diacetylchitobiose-6'-phosphate + H2O = acetate + N'-monoacetylchitobiose-6'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34189", "l": "(2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate => (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696267", "l": "RND3 binds GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168767", "l": "JAK2 phosphorylates STAT1/STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114552", "l": "Thrombin-activated PARs activate G12/13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15844", "l": "D-glucose 6-phosphate + NADP(+) <=> 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624120", "l": "CEBPA binds CDK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.42903515889401", "identifiers": [{"i": "GO:0004618", "l": "phosphoglycerate kinase activity", "d": ["Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036201", "l": "ent-isokaurene C2-hydroxylase activity", "d": ["Catalysis of the reaction: ent-isokaurene + O2 + NADPH + H+ = ent-2alpha-hydroxyisokaurene + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22385", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O => 1D-myo-inositol hexakisphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16082", "l": "(2R)-S-methyl-3-phospho-1-thioglycerate + H2O => (2R)-S-methyl-1-thioglycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66181", "l": "ATP + bilirubin-glucuronoside(in) + H2O => ADP + bilirubin-glucuronoside(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56966", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate => a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15282", "l": "lathosterol => 5alpha-cholest-8-en-3beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47774", "l": "a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => a guanosine in 21S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61389", "l": "ATP + biotin(in) + H2O => ADP + biotin(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47905", "l": "ATP + N-(acetyl)-sphing-4-enine => ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75735", "l": "10-oxo-(12Z)-octadecenoate = 10-oxo-(11E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111930", "l": "Adenylate cyclase produces cAMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693593", "l": "D-loop extension by DNA polymerases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507871", "l": "Aquaporins passively transport glycerol out of cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44382", "l": "a ubiquinol + H(+) + S-adenosyl-L-homocysteine => a 3-demethylubiquinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928610", "l": "PTK2 autophosphorylates at Y397 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050004", "l": "isoflavone 7-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + isoflavone = UDP + isoflavone 7-O-beta-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58083", "l": "1-docosanoylglycerol + H2O <=> docosanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34633", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45791", "l": "(9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol <=> 1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40434", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60903", "l": "a cytidine in RNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031981", "l": "NTRK2-phosphorylated FRS2 binds PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-445714", "l": "Aquaporin-3 passively transports water out of cell (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61637", "l": "ATP + CoA + isophthalate => AMP + diphosphate + isophthalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66901", "l": "acetyl-CoA + L-tryptophan + malonyl-CoA => CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43175", "l": "guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69108", "l": "2-oxo-3-sulfanylpropanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029456", "l": "RAC1 and CDC42 activate PAK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34128", "l": "(2E)-geranyl diphosphate + olivetolate => cannabigerolate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16854", "l": "N(6)-(1,2-dicarboxyethyl)-AMP => AMP + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72084", "l": "ADP-alpha-D-ribose 1'',2''-cyclic phosphate + H2O => ADP-alpha-D-ribose 1''-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986937", "l": "MECP2 is phosphorylated at T308 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16339", "l": "a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983158", "l": "Trimming of peptides in ER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682709", "l": "LGI4 binds ADAM22,23,11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40299", "l": "6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.35", "l": "\"6-deoxyerythronolide B hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67895", "l": "3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine <=> 3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21589", "l": "N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate => H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10264", "l": "alpha-D-glucose = beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74030", "l": "L-alanine(in) + L-threonine(out) <=> L-alanine(out) + L-threonine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197698", "l": "Src phosphorylate WASP,N-WASP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57034", "l": "CO2 + formate + methylamine + succinate semialdehyde => (E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53986", "l": "(11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12286", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + succinate => 3-hydroxy-3-methylglutarate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45016", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine = L-selenomethionine + tetrahydropteroyltri-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008925", "l": "maltose O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42729", "l": "S-adenosyl-L-methionine + uridine(2791) in 21S rRNA => 2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70121", "l": "28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806732", "l": "GNLY binds the bacterial cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019809", "l": "spermidine binding", "d": ["Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14915", "l": "adenosine + dTMP => AMP + thymidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76001", "l": "glutarate(out) + kynurenate(in) => glutarate(in) + kynurenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51021", "l": "a primary alcohol + 2 Fe(III)-[cytochrome c] => an aldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0033844", "l": "galactose-6-sulfurylase activity", "d": ["Catalysis of the elimination of sulfate from the D-galactose 6-sulfate residues of porphyran, producing 3,6-anhydrogalactose residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5672011", "l": "p-AMPK:AMP binds the ULK complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191299", "l": "Squalene is oxidized to its epoxide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376122", "l": "DSCAM/DSCAML1 homodimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42461", "l": "dibenzofuran + H(+) + NADH + O2 => biphenyl-2,2',3-triol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70757", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035497", "l": "cAMP response element binding", "d": ["Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30354", "l": "H(+) + NADH + O2 + pyrrole-2-carboxylate <=> 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9728150", "l": "SLC5A2 binds gliflozins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74931", "l": "2 2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + 2 O2 = a (3R)-3-isocyanyl-fatty acid + 3 CO2 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33839", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) = 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate", "d": []}, {"i": "EC:2.5.1.125", "l": "\"7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000137", "l": "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10757", "l": "ATP + phosphate + pyruvate => AMP + diphosphate + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62032", "l": "a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O = a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2197690", "l": "Detachment of WASP/WAVE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678327", "l": "MIOX oxidises Ins to GlcA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15154", "l": "4-hydroxybenzoate + UDP-alpha-D-glucose => 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20227", "l": "(E)-ferulate + H(+) + S-adenosyl-L-homocysteine => (E)-caffeate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603419", "l": "Activated NTRK3 binds SRC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74715", "l": "Autophosphorylation of insulin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052918", "l": "dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21939", "l": "carbamoyl phosphate + putrescine <=> H(+) + N-carbamoylputrescine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25222", "l": "H(+) + L-cysteate => CO2 + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43416", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013109", "l": "RHOC GEFs activate RHOC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60720", "l": "(E)-hept-2-enal + H2O + NADP(+) = (E)-hept-2-enoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67036", "l": "(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + 2-oxoglutarate + O2 = (3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16309", "l": "H2O + taurochenodeoxycholate = chenodeoxycholate + taurine", "d": []}, {"i": "EC:3.5.1.74", "l": "\"chenodeoxycholoyltaurine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27825", "l": "hydrogen sulfide + O-acetyl-L-homoserine <=> acetate + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42158", "l": "5alpha-androstane-3alpha,17beta-diol + NADP(+) => androsterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57879", "l": "uridine(54) in tRNA <=> pseudouridine(54) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694563", "l": "ABHD10 hydrolyses MPAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18527", "l": "3-methylbutanal + H(+) + NADPH => 3-methylbutanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24286", "l": "4-phospho-L-aspartate + H(+) + NADPH => L-aspartate 4-semialdehyde + NADP(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44567", "l": "4-hydroxybenzoate + all-trans-decaprenyl diphosphate <=> 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109860", "l": "MAP2K1 phosphorylates MAPK3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62548", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69740", "l": "phenylsuccinate + succinyl-CoA => 3-phenylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799330", "l": "The SRP receptor binds the SRP:nascent peptide:ribosome complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14294", "l": "D-glucose + NAD(+) => D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16723", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n) => 5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41251", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12120", "l": "alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate", "d": []}, {"i": "EC:2.7.7.27", "l": "\"glucose-1-phosphate adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.60", "l": "\"scutelarin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55522", "l": "3 diphosphate + nerylneryl diphosphate => dimethylallyl diphosphate + 3 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39025", "l": "an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726580", "l": "PGR binds PGR agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624953", "l": "ARL13B binds INPP5E (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781899", "l": "USP13 binds SIAH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50099", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39583", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18441", "l": "D-dopachrome + H(+) = 5,6-dihydroxyindole + CO2", "d": []}, {"i": "EC:4.1.1.84", "l": "\"D-dopachrome decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68029", "l": "6,8-dihydroxypurine + H2O + O2 => H2O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60048", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951910", "l": "RUNX3 binds the RUNX1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73800", "l": "SAICAR => AICAR + Fumarate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44284", "l": "2 H(+) + 2 malonyl-CoA + octanoyl-CoA = 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917730", "l": "Cargo Recognition And Sorting (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187828", "l": "Translocation of p21 to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45935", "l": "2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043713", "l": "(R)-2-hydroxyisocaproate dehydrogenase activity", "d": ["Catalysis of the reaction: 2-oxoisocaproate + NADH + H+ = (R)-2-hydroxyisocaproate + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65985", "l": "hnu + previtamin D3 => lumisterol 3", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050014", "l": "ketotetrose-phosphate aldolase activity", "d": ["Catalysis of the reaction: L-erythrulose 1-phosphate = formaldehyde + glycerone phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856525", "l": "ANGPTL8 binds ANGPTL3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0010334", "l": "sesquiterpene synthase activity", "d": ["Catalysis of the reaction: trans,trans-farnesyl diphosphate = a sesquiterpene + diphosphate. Sesquiterpenes are terpenes containing three isoprene units, i.e. 15 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14815", "l": "D-2-aminohexano-6-lactam => L-2-aminohexano-6-lactam", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21183", "l": "1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol <=> D-glucose + indole-3-acetyl-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37135", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-996755", "l": "ZFPM proteins bind GATA proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18936", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA <=> (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15278", "l": "acetyl-CoA + L-lysyl-[alpha-tubulin] => CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396395", "l": "HSPG2 (perlecan) binds alpha-dystroglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23383", "l": "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48315", "l": "benzoyl-CoA + H(+) + NADPH + O2 <=> 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202245", "l": "Phosphorylation of TBSMs in LAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617828", "l": "TRIP11:IFT20 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48597", "l": "1,2-didecanoylglycerol + H2O => decanoate + decanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18514", "l": "D-mannitol + O2 => D-mannose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254251", "l": "ERBB4s80 binds YAP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20483", "l": "adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate => 3'-phosphoadenylyl sulfate + coelenterazine h", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38576", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70573", "l": "argininosuccinate <=> fumarate + arginine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51345", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69965", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + teasterone => 6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74289", "l": "an acyl-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + holo-[ACP] => a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55044", "l": "(3E,5Z)-tetradecadienoyl-CoA + H2O = (3E,5Z)-tetradecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75557", "l": "erinacol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-cyatha-3,12-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5681980", "l": "ATG12 binds ATG7 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800797", "l": "The PIDDosome activates CASP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33244", "l": "L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32236", "l": "(6S)-NADPHX + ADP => AMP + H(+) + NADPH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202692", "l": "PIP3 binds to RhoA and activates it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033702", "l": "(+)-trans-carveol dehydrogenase activity", "d": ["Catalysis of the reaction: (1R,5S)-carveol + NAD+ = (S)-carvone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23962", "l": "CO2 + 3 H2O + pentadecanal => H(+) + 2 H2O2 + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031928", "l": "pyridoxine transmembrane transporter activity", "d": ["Enables the transfer of pyridoxine from one side of a membrane to the other. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357445", "l": "PAK1-3 dimer disassociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65791", "l": "diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72980", "l": "didemethylasterriquinone D + dimethylallyl diphosphate => asterriquinone C1 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28654", "l": "inosine + O2 <=> 9-riburonosylhypoxanthine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418200", "l": "SRC-1 bound to ARRB2 is not activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218804", "l": "p38 MAPK activation by VEGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60760", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone = CoA + jasmolin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685607", "l": "Sialic acid binds SIGLEC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62854", "l": "GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190520", "l": "Association of Golgi  transport vesicles with microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64891", "l": "ATP + holo-[ACP] + tetradecanoate <=> AMP + diphosphate + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42438", "l": "L-ascorbate 6-phosphate(in) + L-histidyl-[protein] => L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43063", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate <=> beta-D-glucose 1-phosphate + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672978", "l": "RAF phosphorylates MAP2K dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70852", "l": "H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out) => H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64184", "l": "H2O + N-(9Z-octadecenoyl)-L-tyrosine = (9Z)-octadecenoate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2301205", "l": "SETD8 monomethylates histone H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433456", "l": "Recruitment of STATs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35486", "l": "5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52164", "l": "O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] = (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.77", "l": "\"phenylacetonitrile alpha-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954082", "l": "E2F6 binds the PRC1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8960973", "l": "RLBP1:11cRAL dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404200", "l": "IGF1,2 binds IGF1R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42858", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate => 1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62018", "l": "3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP => L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19505", "l": "indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.2.34", "l": "\"indolylacetylinositol arabinosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71490", "l": "H2O + Leu-enkephalin <=> L-phenylalanyl-L-leucine + L-tyrosylglycylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358790", "l": "RNF41 ubiquitinates ERBB3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11378", "l": "4,21-dehydrogeissoschizine + NADPH => (19E)-geissoschizine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373747", "l": "Phosphorylation of nephrin by FYN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35539", "l": "cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 = albonoursin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703895", "l": "CASR binds CASR agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.-", "l": "\"Aldehyde-lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68847", "l": "(2Z,6E)-farnesyl diphosphate <=> (Z)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10250", "l": "diphosphate + dUMP + H(+) => dUTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666008", "l": "SCAI binds SRF:MKL1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182988", "l": "Sprouty lures CBL away from EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110311", "l": "POLZ extends translesion synthesis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16490", "l": "(R)-prunasin + H2O => D-glucose + mandelonitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670149", "l": "TERRA transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32510", "l": "4-isopropenyl-7-methyloxepan-2-one + H2O <=> 6-hydroxy-3-isopropenylheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008662", "l": "1-phosphofructokinase activity", "d": ["Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985343", "l": "RUNX2 binds SOX9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56254", "l": "H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395320", "l": "Latent TGF-beta-1 binds integrins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.374", "l": "\"2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430096", "l": "GP1b-IX-V binds filamin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18700", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) <=> (4-hydroxyphenyl)acetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16115", "l": "2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH => 2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39062", "l": "26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009558", "l": "IL34 dimer binds SDC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805638", "l": "KAT6A acetylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48421", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) => CMP + ganglioside GM1 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983700", "l": "SYK binds the activated BCR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0032036", "l": "myosin heavy chain binding", "d": ["Binding to a heavy chain of a myosin complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46288", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34606", "l": "15-methylhexadecasphinganine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-15-methylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205321", "l": "Interaction of KIT and sSCF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65535", "l": "2-methylbutan-1-ol + hexanoyl-CoA <=> 2-methylbutyl hexanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55138", "l": "D-alanyl-5'-AMP + diphosphate => ATP + D-alanine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40176", "l": "O2 + octanoyl-CoA => (2E)-octenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59814", "l": "CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein] => hexadecanoyl-CoA + N-terminal glycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956676", "l": "YAP1 binds TP73 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0004357", "l": "glutamate-cysteine ligase activity", "d": ["Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139905", "l": "Translocation of activated BAD protein to mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209944", "l": "25(OH)D binds GC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985591", "l": "SLIT2-bound ROBO1 binds MYO9B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49422", "l": "ADP + H(+) + valienone 7-phosphate => ATP + valienone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49845", "l": "(-)-dehydrodiconiferyl acid + a quinone => (-)-dehydrodiconiferyl acid ketone + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805811", "l": "Release of SEPT4 from mitochondria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73407", "l": "(S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12765", "l": "CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate = acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019117", "l": "dihydroxyfluorene dioxygenase activity", "d": ["Catalysis of the reaction: a dihydroxyfluorene + O2 = the corresponding 2-hydroxy-4-(oxo-1,3-dihydro-2H-inden-ylidene) but-2-enoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29020", "l": "D-galactose(in) + H(+)(in) => D-galactose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35659", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose = GDP + H(+) + mannosylinositol phosphorylphytoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62676", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide = 6-thio-IMP + 7,8-dihydrofolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008117", "l": "sphinganine-1-phosphate aldolase activity", "d": ["Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27771", "l": "3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12706", "l": "[protein]-L-isoaspartate + S-adenosyl-L-methionine => [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27964", "l": "H(+) + pyrroloquinoline quinol + scyllo-inosose => myo-inositol + pyrroloquinoline quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-532603", "l": "Nephrin mediated activation of N-WASP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33983", "l": "(+)-copalyl diphosphate = diphosphate + miltiradiene", "d": []}, {"i": "EC:4.2.3.131", "l": "\"miltiradiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73614", "l": "CTP(out) + dCDP(in) <=> CTP(in) + dCDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59781", "l": "L-histidine + S-adenosyl-L-methionine => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17745", "l": "N-acetyl-D-glucosamine + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.90", "l": "\"N-acetyllactosamine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27288", "l": "diacetyl + H(+) + NADH => (S)-acetoin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132061", "l": "Complement factor B binds to surface-bound C3b fragment (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12071", "l": "apo-[ACP] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0004033", "l": "aldo-keto reductase (NADP) activity", "d": ["Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41263", "l": "NAD(+) + prostaglandin A1 = 15-oxo-prostaglandin A1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939833", "l": "RUNX2:CBFB binds the ITGBL1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950778", "l": "p-Y693-STAT4 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37346", "l": "adenosine 2'-phosphate + H2O <=> adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57434", "l": "1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => 3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24164", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]", "d": []}, {"i": "EC:1.8.4.12", "l": "\"peptide-methionine (R)-S-oxide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20660", "l": "4-chlorophenylacetonitrile + 2 H2O <=> 4-chlorophenylacetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450348", "l": "Activated human JNKs migrate to nucleoplasm (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53333", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 => 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871373", "l": "BMX phosphorylates RUFY1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57568", "l": "7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694662", "l": "Protein 3a forms a homotetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683774", "l": "p-T68-CHEK2 dimerizes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53214", "l": "17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73310", "l": "H(+)(in) + L-aspartate(out) + phosphate(in) <=> H(+)(out) + L-aspartate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62845", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose => beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36138", "l": "(2E)-hexadecenal + H2O + NAD(+) <=> (E)-hexadec-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983156", "l": "Polyubiquitination of substrate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36693", "l": "CoA + H(+) + N-octadecanoylsphing-4-enine => octadecanoyl-CoA + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043911", "l": "D-lysine transaminase activity", "d": ["Catalysis of the reaction: D-lysine + 2-oxoglutarate = L-glutamate + 6-amino-2-oxohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64078", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+) => 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47681", "l": "D-galactosamine 6-phosphate + H2O => D-tagatopyranose 1-phosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804741", "l": "MDM2 forms homo- or heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47144", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936616", "l": "RUNX1 and GATA1 bind the promoter of the GP1BA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35419", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP", "d": []}, {"i": "EC:2.4.1.297", "l": "\"anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009885", "l": "transmembrane histidine kinase cytokinin receptor activity", "d": ["Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.43", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59318", "l": "D-cellobiono-1,5-lactone + H2O2 => D-cellobiose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070677", "l": "rRNA (cytosine-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylcytosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60253", "l": "(S)-methylmalonyl-CoA + NADP(+) => acryloyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72613", "l": "H(+)(in) + L-alanyl-L-lysine(in) => H(+)(out) + L-alanyl-L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754964", "l": "ADA deamidates RBV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001517", "l": "N-acetylglucosamine 6-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682826", "l": "LGI1 binds ADAM11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75713", "l": "a rhodoquinol + fumarate => a rhodoquinone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.14", "l": "\"rhodopsin kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16138", "l": "2'-deoxymugineate + NADP(+) => 3''-deamino-3''-oxonicotianamine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.101", "l": "\"mannan endo-1,6-alpha-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389762", "l": "Phosphorylation of PD-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32922", "l": "H2O + methyl (indol-3-yl)acetate <=> (indol-3-yl)acetate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670426", "l": "Disassociation and translocation of STATs to the nucleus downstream of KIT mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990081", "l": "trimethylamine receptor activity", "d": ["Combining with the biogenic amine trimethylamine to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65027", "l": "7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+) <=> dehydrocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193669", "l": "TRAF6 binds to p75NTR:NRIF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851018", "l": "BTN2A1 binds DC-SIGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004952", "l": "dopamine neurotransmitter receptor activity", "d": ["Combining with the neurotransmitter dopamine to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33521", "l": "(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67695", "l": "ATP + H2O + hexadecanedioate(in) <=> ADP + H(+) + hexadecanedioate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607733", "l": "BCL10 binds CARD9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9737780", "l": "MTTP binds lomitapide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34711", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine = 15-methylhexadecasphing-4-enine + a fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102593", "l": "UDP-glucose: N-methylanthranilate glucosyltransferase activity", "d": ["Catalysis of the reaction: N-methylanthranilate + UDP-alpha-D-glucose = N-methylanthraniloyl-beta-D-glucopyranose + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55121", "l": "4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54000", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166538", "l": "The bound receptor dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63795", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50289", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10140", "l": "NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin D2", "d": []}, {"i": "EC:1.1.1.188", "l": "\"prostaglandin-F synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42683", "l": "2 hercynine + 2 L-selenocysteine + O2 <=> 2 H2O + 2 hercynylselenocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19476", "l": "4-hydroxybenzoate + H(+) + NADH + O2 <=> 3,4-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50282", "l": "(5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036020", "l": "Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)8 (PP-Dol)1 by ALG9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2509831", "l": "ITPA hydrolyses XTP to XMP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19760", "l": "(3R)-3-hydroxy-L-aspartate <=> NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809309", "l": "MTMR6 binds MTMR9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73347", "l": "beta-alanyl-[peptidyl-carrier protein] + tryptamine = beta-alanyl-tryptamine + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186773", "l": "PDGF dimer binds two receptors simultaneously (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983421", "l": "Journey of cargo through Golgi complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73805", "l": "diphosphate + isoechinulin B => dimethylallyl diphosphate + neoechinulin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944216", "l": "Association of procollagen type XV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0070679", "l": "inositol 1,4,5 trisphosphate binding", "d": ["Binding to inositol 1,4,5 trisphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0010844", "l": "recombination hotspot binding", "d": ["Binding to a genomic region which promotes recombination."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66948", "l": "acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate = alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CoA", "d": []}, {"i": "EC:2.3.1.303", "l": "\"alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und 2(IV)-O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41837", "l": "H(+) + hexanoyl-[ACP] + malonyl-[ACP] => 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52247", "l": "4 H(+) + 4 Mn(2+) + O2 <=> 2 H2O + 4 Mn(3+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21882", "l": "2 CO2 + H2O2 => 2 H(+) + O2 + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16857", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.113", "l": "\"site-specific DNA-methyltransferase (cytosine-N(4)-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46149", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71708", "l": "H(+)(out) + L-phenylalanyl-L-phenylalanine(out) => H(+)(in) + L-phenylalanyl-L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60228", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34886", "l": "ATP + H2O + selenate(out) <=> ADP + H(+) + phosphate + selenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110311", "l": "POLZ extends translesion synthesis (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57193", "l": "H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] => glycolate + H(+) + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.89", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39932", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68610", "l": "Formation of ORC(2-5) complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35704", "l": "1'-hydroxyversicolorone + H(+) + NADPH + O2 => (2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47031", "l": "[DsrC protein]-S-sulfo-L-cysteine/L-cysteine <=> [DsrC protein]-disulfide + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39287", "l": "Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + trimethylamine = dimethylamine + methyl-Co(III)-[trimethylamine-specific corrinoid protein]", "d": []}, {"i": "EC:2.1.1.250", "l": "\"[trimethylamine--corrinoid protein] Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39207", "l": "3-oxohexacosanoyl-CoA + H(+) + NADPH = (3R)-hydroxyhexacosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.45", "l": "\"FAD reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45378", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102459", "l": "8-oxo-dADP diphosphate phosphatase activity", "d": ["Catalysis of the reaction: 8-oxo-dADP + H2O = 8-oxo-dAMP + hydrogenphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63551", "l": "angiotensin-(1-9) + H2O <=> angiotensin-(1-7) + L-phenylalanyl-L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.26", "l": "\"2,4-diaminopentanoate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850831", "l": "KLK5 cleaves and activates KLK8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000327", "l": "PLK1 phosphorylates BORA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29103", "l": "5 H(+)(in) + menaquinone-8 + NADH = 4 H(+)(out) + menaquinol-8 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73546", "l": "dCDP(out) + UTP(in) <=> dCDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55599", "l": "globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine <=> globoside NORint + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75156", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => diphosphate + verrucosan-2beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35597", "l": "2 H(+) + maleylacetate => benzene-1,2,4-triol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72559", "l": "estrone 3-sulfate(out) + pentanoate(in) = estrone 3-sulfate(in) + pentanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19333", "l": "H(+) + oxalyl-CoA = CO2 + formyl-CoA", "d": []}, {"i": "EC:4.1.1.8", "l": "\"oxalyl-CoA decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607747", "l": "TRAF6 binds MALT1 oligomers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43093", "l": "S-adenosyl-L-methionine + uridine(2479) in 23S rRNA => 2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13521", "l": "(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": []}, {"i": "EC:1.1.2.4", "l": "\"D-lactate dehydrogenase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42043", "l": "ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose <=> gangliosideFuc-GM1 (d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-481010", "l": "Surface deployment of platelet dense granule membrane components (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-996727", "l": "REST recruits the BHC complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56266", "l": "CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26099", "l": "H2O + limonene 1,2-epoxide + NADP(+) => (4R)-limonene + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204850", "l": "Interaction of Tie2 and Dok-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54838", "l": "H2O + NADP(+) + pentyl acetate => H(+) + heptan-2-one + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13039", "l": "ITP + NH4(+) => ATP + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10106", "l": "CO2 + gibberellin A1 + succinate => 2-oxoglutarate + gibberellin A20 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939204", "l": "ESTG binds ESR1:chaperone complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34226", "l": "6-hydroxypseudooxynicotine + A + H2O <=> 2,6-dihydroxypseudooxynicotine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50423", "l": "L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] <=> H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75772", "l": "(9Z,12Z,15Z)-octadecatrienoate + H2O => (10S)-hydroxy-(12Z,15Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16621", "l": "dihydrosanguinarine + H(+) + O2 = H2O2 + sanguinarine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12823", "l": "acetaldehyde + D-glyceraldehyde 3-phosphate => 2-deoxy-D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24048", "l": "phosphate + sucrose = alpha-D-glucose 1-phosphate + D-fructose", "d": []}, {"i": "EC:2.4.1.7", "l": "\"sucrose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14140", "l": "3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine <=> 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19758", "l": "(3R)-3-hydroxy-L-aspartate => NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2562541", "l": "TLR4-induced ripoptosome assembly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.46", "l": "\"adamalysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852019", "l": "MET bound PI3K generates PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182198", "l": "Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866941", "l": "MID1IP1 binds THRSP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "60.282684029872676", "identifiers": [{"i": "GO:0016874", "l": "ligase activity", "d": ["Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient."]}, {"i": "EC:6.-.-.-", "l": "\"Ligases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390329", "l": "Dephosphorylation of AKT by PP2A (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052741", "l": "(R)-limonene 6-monooxygenase activity", "d": ["Catalysis of the reaction: (4R)-limonene + H+ + NADPH + O2 = (1R,5S)-carveol + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20213", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein] = L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein]", "d": []}, {"i": "EC:2.3.1.204", "l": "\"octanoyl-[GcvH]:protein N-octanoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674529", "l": "AAMP binds to TBXA2R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25185", "l": "1,2-dichloroethane + H2O = 2-chloroethanol + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070182", "l": "DNA polymerase binding", "d": ["Binding to a DNA polymerase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693347", "l": "HTR1A binds 5HT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.5", "l": "\"cucurbitacin Delta(23)-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47272", "l": "monoanhydrobacterioruberin = bisanhydrobacterioruberin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018724", "l": "4-phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: 4-phenanthrol + X-SO3(-) = HX + 4-phenanthrylsulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.302", "l": "\"hydroxycinnamoyl-CoA:5-hydroxyanthranilate N-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45882", "l": "4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA => 3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753634", "l": "GGT dimers hydrolyse APAP-SG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9679044", "l": "FKBP1A binds sirolimus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54991", "l": "4 e(-) + 4 H(+)(in) + O2(in) <=> 2 H2O(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668735", "l": "RAC1:GTP binds NOX3 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904599", "l": "advanced glycation end-product binding", "d": ["Binding to advanced glycation end-product."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218832", "l": "CDC42:GTP binds PAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45614", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine => H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36447", "l": "ATP + glycyl-L-proline(out) + H2O = ADP + glycyl-L-proline(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1268022", "l": "TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109862", "l": "MAP2K2 phosphorylates MAPK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1006169", "l": "Factor H binds host cell surface markers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909552", "l": "Phosphorylation of STAT1 at Ser727 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788622", "l": "p-Y-STATs dimerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000327", "l": "PLK1 phosphorylates BORA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50983", "l": "prostaglandin E1(out) <=> prostaglandin E1(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814695", "l": "PERP binds desmosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1878002", "l": "XYLTs transfer Xyl to core protein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67157", "l": "1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008107", "l": "galactoside 2-alpha-L-fucosyltransferase activity", "d": ["Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44759", "l": "2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39487", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA = (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34043", "l": "5-phospho-alpha-D-ribose 1-diphosphate + neamine = 5''-phosphoribostamycin + diphosphate", "d": []}, {"i": "EC:2.4.2.49", "l": "\"neamine phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39823", "l": "eicosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2-hydroxyeicosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2395517", "l": "NADPH transfers electrons to FDXR (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59477", "l": "2 AH2 + 2 ATP + benzoate + L-phenylalanine => 2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70495", "l": "D-glucose(out) + 2 Na(+)(out) = D-glucose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814674", "l": "Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33211", "l": "1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+) = 2-demethylmenaquinol-7 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004771", "l": "sterol esterase activity", "d": ["Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32175", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72209", "l": "chloride(in) + 2 hydrogencarbonate(out) => chloride(out) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2059926", "l": "NPHP4 protein binds LATS proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806957", "l": "MET receptor dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964284", "l": "BTK in active Gq-BTK complex is activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63802", "l": "GDP-beta-L-gulose => GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944242", "l": "Association of procollagen type XXVII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37892", "l": "aclacinomycin T + H2O => 15-demethylaclacinomycin T + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004796", "l": "thromboxane-A synthase activity", "d": ["Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9029690", "l": "Caspase-6 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67262", "l": "(E)-hept-2-enoate + 2 H(+) + NADH => (E)-hept-2-enal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36068", "l": "Co-precorrin-6B + S-adenosyl-L-methionine => Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27738", "l": "2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17710", "l": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate => 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41958", "l": "cytidine 2'-phosphate + H(+) => 2',3'-cyclophospho-CMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49627", "l": "ATP + erythritol <=> ADP + D-erythritol 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60860", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17749", "l": "A + H2O + quinoline = AH2 + quinolin-2(1H)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69152", "l": "Removal of remaining Flap (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388814", "l": "Grb2 binds CD28 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014294", "l": "RAC2 binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444527", "l": "FPR is a receptor for formyl peptides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610723", "l": "GLI proteins bind SUFU (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31791", "l": "H2O + tuberculosinyl diphosphate = (13S)-edaxadiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46003", "l": "adenosine + H(+) + tuberculosinyl diphosphate <=> 1-tuberculosinyladenosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198599", "l": "AKT phosphorylates MDM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58089", "l": "1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O => (7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59680", "l": "D-maltopentaose + O2 = D-maltopentaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16708", "l": "17alpha-estradiol + NADP(+) <=> estrone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60520", "l": "2 H2O + L-cystine-bis-glycine = 2 glycine + L-cystine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26331", "l": "(7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate => (8S)-8-amino-7-oxononanoate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018642", "l": "chlorophenol 4-monooxygenase activity", "d": ["Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62414", "l": "acetyl-CoA + vanillin => (E)-feruloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.74", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796691", "l": "SPATA2 links CYLD to LUBAC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72831", "l": "3',3'-cGAMP + H2O = G[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67111", "l": "L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047863", "l": "dimethylallylcistransferase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52678", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine => [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53722", "l": "ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate => ATP + N-acetyl-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11880", "l": "(S)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2", "d": []}, {"i": "EC:1.5.3.5", "l": "\"(S)-6-hydroxynicotine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22816", "l": "alpha-D-xylose = alpha-D-xylulofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50073", "l": "ATP + H2O + tauroursodeoxycholate(in) => ADP + H(+) + phosphate + tauroursodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61855", "l": "campesterol + UDP-alpha-D-glucose <=> campesteryl 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55116", "l": "5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3134962", "l": "DHX36 binds DNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106238", "l": "peregrinol diphosphate synthase activity", "d": ["Catalysis of the reaction:peregrinol diphosphate = all-trans-geranylgeranyl diphosphate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199062", "l": "KLRC1:KLRD1 heterodimer interacts with HLA-E (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621370", "l": "SYK autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19060", "l": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione <=> a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9656244", "l": "DRD2 binds DA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66914", "l": "avenanthramide B + H(+) + S-adenosyl-L-homocysteine => avenanthramide C + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59513", "l": "acetylsalicylate + L-seryl-[protein] => O-acetyl-L-seryl-[protein] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961671", "l": "E2F1 binds the ORC1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873850", "l": "STARD5 binds DCA, LCA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28574", "l": "H(+)(in) + sulfate(in) = H(+)(out) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870469", "l": "RGGT geranylgeranylates RAB proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60220", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63460", "l": "(2E,6E,10E)-geranylgeraniol + GTP = (2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51916", "l": "(2S)-2-amino-3-butenoate + H2O = 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632804", "l": "SLC2A1 tetramer does not transport Glc from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937419", "l": "CBR3 reduces DOX to DOXOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42488", "l": "(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III = 3'-N-debenzoyl-2'-deoxytaxol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680836", "l": "NS5B binds ribavirin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66972", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose = alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.381", "l": "\"dTDP-Rha:alpha-D-Man-(1->3)-alpha-D-Gal diphosphoundecaprenol alpha-1,2-rahmnosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839078", "l": "Cytosolic FGFR1 fusion proteins bind PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388503", "l": "Oxytocin receptor bind oxytocin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75190", "l": "2,5-dihydroxybenzoyl-CoA + H2O <=> 2,5-dihydroxybenzoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11833", "l": "(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) => H(+) + NADH + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0008796", "l": "bis(5'-nucleosyl)-tetraphosphatase activity", "d": ["Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20344", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose <=> 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428625", "l": "Vesicular inhibitory amino acid transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2317314", "l": "AKT binds PDPK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68001", "l": "1,1-dichloroethene + AH2 => A + chloride + chloroethene + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848818", "l": "PTK6 phosphorylates CBL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39825", "l": "2-hydroxyeicosanoate + 2 Fe(III)-[cytochrome b5] + H2O => eicosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27577", "l": "(3R)-piperidine-3-carboxamide + H2O <=> (3R)-piperidine-3-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56220", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21215", "l": "H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] <=> 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21946", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+) => ATP + D-cellobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36720", "l": "hexacosenoyl-CoA + sphinganine => CoA + H(+) + N-hexacosenoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102379", "l": "steviolbioside glucosyltransferase activity (stevioside forming)", "d": ["Catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = stevioside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373748", "l": "SEMA4D interacts with CD72 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390425", "l": "FAR1 reduces PalmCoA to HXOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-976801", "l": "Complement factor I complex formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65303", "l": "2-oxoglutarate + chrodrimanin C + O2 <=> CO2 + H2O + succinate + verruculide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68112", "l": "H2O + propanamide = NH4(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432143", "l": "PECAM-1 binds PP2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42001", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448963", "l": "Interaction of MyoD:E protein with MEF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29477", "l": "(+)-cubenene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45655", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74274", "l": "an alpha-Kdo-(2->6)-lipid IVA + ATP <=> a 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53651", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-corvol ether A + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36795", "l": "a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071734", "l": "biotin-[pyruvate-carboxylase] ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + apo-(pyruvate-carboxylase) = AMP + diphosphate + biotin-(pyruvate-carboxylase)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44092", "l": "ATP + CoA + nonadecanoate = AMP + diphosphate + nonadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203553", "l": "eNOS binds NOSIP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004869", "l": "cysteine-type endopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228840", "l": "Defective IKBKB (IKK2) does not form a complex with IKBKA and IKBKG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433986", "l": "activated IKKs phosphorylates IkB alpha causing the NFkB complex to dissociate from the  phospho-IkB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73253", "l": "H(+) + S-adenosyl-L-homocysteine + salvigenin => cirsimaritin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052672", "l": "CTP:geranylgeraniol kinase activity", "d": ["Catalysis of the reaction: geranylgeraniol + CTP = all-trans-geranyl-geranyl monophosphate + CDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38287", "l": "(3S)-citramalate + succinyl-CoA = (3S)-citramalyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390929", "l": "HTR1 and 5A receptors can bind serotonin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56086", "l": "[Rab1 protein]-L-serine + H(+) + phosphocholine => [Rab1 protein]-O-phosphocholine-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050256", "l": "ribitol-5-phosphate 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64735", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40282", "l": "(R)-carnitine + dodecanoyl-CoA <=> CoA + O-dodecanoyl-R-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70857", "l": "L-glutamine(in) + L-serine(out) + Na(+)(in) => L-glutamine(out) + L-serine(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9676254", "l": "Formation of the MLL3 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33893", "l": "chanoclavine-I aldehyde + H(+) + NADH => chanoclavine-I + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928646", "l": "EPHAs bind EFNAs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977224", "l": "Serum amyloid P binds DNA and chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679239", "l": "ULK complex translocates to the ER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23804", "l": "N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate", "d": []}, {"i": "EC:5.4.2.3", "l": "\"phosphoacetylglucosamine mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16989", "l": "1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate", "d": []}, {"i": "EC:3.1.3.8", "l": "\"3-phytase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.3", "l": "\"uridine nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805276", "l": "CDK5 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16336", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] <=> diphosphate + holo-[citrate lyase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65947", "l": "AH2 + CTP + S-adenosyl-L-methionine <=> 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032141", "l": "single cytosine insertion binding", "d": ["Binding to a double-stranded DNA region containing a single cytosine insertion or a deletion that results in an unpaired cytosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871265", "l": "YAP1 binds TEAD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018447", "l": "chloral hydrate dehydrogenase activity", "d": ["Catalysis of the reactions: chloral hydrate = 3 H+ + 2 e- + trichloroacetate, and chloral hydrate + H2 = H2O + trichloroethanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35609", "l": "diacetyl + H(+) + NADPH => acetoin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.359", "l": "\"aldose 1-dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46703", "l": "(R)-lipoate + GTP + H(+) <=> (R)-lipoyl-GMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55552", "l": "N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450533", "l": "PKCdelta phosphorylates HuR (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68834", "l": "(6Z)-nerolidol + diphosphate => (2Z,6Z)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31041", "l": "(2E)-dodecenoyl-CoA + FADH2 => dodecanoyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624953", "l": "ARL13B binds INPP5E (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28033", "l": "[thioredoxin]-disulfide + dGDP + H2O <=> [thioredoxin]-dithiol + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21625", "l": "FMNH2 + NADP(+) => FMN + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23102", "l": "ADP + dADP => ATP + dAMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37979", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine = 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14378", "l": "(3R)-3-hydroxy-L-aspartate => glycine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37302", "l": "H2O + L-alanyl-L-threonine <=> L-alanine + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030734", "l": "polysaccharide O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68603", "l": "ORC5 binds ORC2:ORC3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190261", "l": "FGFR3c binds to FGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13024", "l": "H(+) + NADH + O2 + vanillate <=> 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44312", "l": "1-tetradecanoylglycerol + H2O = glycerol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12839", "l": "ADP + H(+) + phosphocholine => ATP + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60003", "l": "hydroxymethylphosphonate + O2 <=> formate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693347", "l": "HTR1A binds 5HT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72737", "l": "UDP-N-acetyl-alpha-D-galactosamine(out) + UMP(in) => UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30075", "l": "CMP + H2O = cytosine + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22051", "l": "7,8-dihydroneopterin 3'-triphosphate <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30724", "l": "A + 2 ADP + H(+) + NH4(+) + 2 phosphate => AH2 + 2 ATP + H2O + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30369", "l": "adenosylcob(III)alamin + phosphate => adenosylcob(III)alamin 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42853", "l": "3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine => (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37287", "l": "ATP + H2O + L-alanyl-L-leucine(out) = ADP + H(+) + L-alanyl-L-leucine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41693", "l": "1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9660192", "l": "VDR agonists bind VDR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62722", "l": "betaenone B + 3 H2O + 3 NADP(+) => 3 H(+) + 3 NADPH + 3 O2 + probetaenone I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3209165", "l": "ID1 sequesters ETS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870465", "l": "RGGT binds the RAB-binding subunit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015131", "l": "oxaloacetate transmembrane transporter activity", "d": ["Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879221", "l": "PSTPIP1 binds Pyrin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55390", "l": "(3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2 => (3R)-3-hydroxy-2,3-dihydrotabersonine + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264834", "l": "Endocytosis and degradation of apoA-I (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.10", "l": "\"pectin lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38842", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004350", "l": "glutamate-5-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-744887", "l": "Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48542", "l": "dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) => 1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849435", "l": "PTPN1 dephosphorylates PTK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804955", "l": "ATM phosphorylates MDM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52807", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-eremophilene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38231", "l": "(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48649", "l": "lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44197", "l": "3-methylundecanoate + ATP + CoA => 3-methylundecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111879", "l": "PIP2 hydrolysis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669158", "l": "NF2 binds PAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.2.3", "l": "\"thiazoline synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65564", "l": "(9Z)-octadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786421", "l": "CHIA hydrolyses chitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.14", "l": "\"lignin peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74453", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45439", "l": "H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.-", "l": "\"Acting on acid anhydrides; catalyzing transmembrane movement of substances\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791349", "l": "TP53 binds the APAF1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32094", "l": "3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine <=> dTDP + erythromycin D + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787567", "l": "TRIT1 transfers dimethylallyl group to adenosine-37 of tRNA(Ser) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0042903", "l": "tubulin deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate."]}, {"i": "REACT:R-HSA-5618331", "l": "HDAC6 deacetylates microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25077", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58374", "l": "(2E)-octenal + H(+) + NADPH => (E)-oct-2-en-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74214", "l": "H2O + L-threonyl-tRNA(Lys) <=> L-threonine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001068", "l": "transcription regulatory region RNA binding", "d": ["Binding to a RNA region within the transcript that regulates the transcription of a gene, cistron, or operon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52997", "l": "[eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH => [eIF5A protein]-deoxyhypusine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69342", "l": "(Z)-propanethial S-oxide => (E)-prop-1-en-1-SO-peroxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51743", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A <=> a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797553", "l": "Protein 4.1 binds CASK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018470", "l": "4-hydroxybutaraldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 4-hydroxybutyraldehyde + H2O = 2 H+ + 2 e- + 4-hydroxybutanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190258", "l": "FGFR2c binds to FGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73819", "l": "choline(in) + 2 H(+)(out) = choline(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30474", "l": "(2Z,6Z)-farnesyl diphosphate <=> (1S,5S,6S)-alpha-bergamotene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40757", "l": "1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate => (9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659611", "l": "ANO1 inhibitors bind ANO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22836", "l": "a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.41", "l": "\"beta-ketoacyl-[acyl-carrier-protein] synthase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791056", "l": "Expression of CCL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008893", "l": "guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity", "d": ["Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031786", "l": "type 1B melatonin receptor binding", "d": ["Binding to a type 1B melatonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44739", "l": "acetyl-CoA + dihydroxyacetone phosphate <=> 3-hydroxy-2,4-dioxopentyl phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61578", "l": "(3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH => (4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43100", "l": "S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.211", "l": "\"tRNA(Ser) (uridine(44)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48217", "l": "H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62978", "l": "(9Z,12Z,15Z)-octadecatrienoate + NH4(+) => (9Z,12Z,15Z)-octadecatrienamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35961", "l": "demethoxyfumitremorgin C + 2 H2O + NADP(+) => H(+) + NADPH + O2 + tryprostatin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43606", "l": "2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018588", "l": "tri-n-butyltin dioxygenase activity", "d": ["Catalysis of the reaction: tri-n-butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyldibutyltin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62911", "l": "nor-toralactone + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + toralactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71003", "l": "L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57874", "l": "CoA + umbelliferone => (E)-2,4-dihydroxycinnamoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432054", "l": "Aquaporin-1 passively transports water out of cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163310", "l": "TFAM binds to mitochondrial promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28356", "l": "(2E)-decenoyl-CoA + FADH2 => decanoyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42742", "l": "H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55395", "l": "an adenosine in mRNA + S-adenosyl-L-methionine <=> an N(1)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72959", "l": "(R)-3-hydroxybutanoate(out) + 2 Na(+)(out) = (R)-3-hydroxybutanoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443778", "l": "Interaction of L1 with Laminin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38664", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33565", "l": "(4R)-hydroxysphinganine 1-phosphate + ADP + H(+) => (4R)-hydroxysphinganine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950354", "l": "STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75868", "l": "5,6,7,8-tetrahydromethanopterin + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => 5-methyl-5,6,7,8-tetrahydromethanopterin + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40963", "l": "4 2-aminophenol + 3 O2 = 2 2-aminophenoxazin-3-one + 6 H2O", "d": []}, {"i": "EC:1.10.3.4", "l": "\"o-aminophenol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799466", "l": "TP53I3 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67563", "l": "3'-phosphoadenylyl sulfate + taurocholate <=> adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483186", "l": "PC is converted to PS by PTDSS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047462", "l": "phenylalanine racemase (ATP-hydrolyzing) activity", "d": ["Catalysis of the reaction: L-phenylalanine + ATP + H2O = D-phenylalanine + AMP + diphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48582", "l": "[pyruvate, water dikinase] + diphosphate => [pyruvate, water dikinase]-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606789", "l": "ARSB hydrolyses DS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27789", "l": "2-oxoglutarate + CoA + NAD(+) <=> CO2 + NADH + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473584", "l": "Collagen type III degradation by MMP15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43111", "l": "2 Fe(III)-[cytochrome c] + H2O + N2 <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12537", "l": "H(+) + L-arogenate => CO2 + H2O + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74972", "l": "L-leucine(out) + L-lysine(in) + Na(+)(out) => L-leucine(in) + L-lysine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20950", "l": "CO2 + sulfoacetaldehyde => 3-sulfopyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51713", "l": "keto-D-tagatose 6-phosphate => keto-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60330", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5213464", "l": "RIPK1 is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043896", "l": "glucan 1,6-alpha-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D-glucans and derived oligosaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67819", "l": "a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O <=> a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66726", "l": "H2O + N-[(S)-lactoyl]-L-phenylalanine => (S)-lactate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033221", "l": "ATPase-coupled urea transmembrane transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + urea(out) = ADP + phosphate + urea(in)."]}, {"i": "RHEA:32803", "l": "ATP + H2O + urea(out) = ADP + H(+) + phosphate + urea(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44287", "l": "2 H(+) + 2 malonyl-CoA + octanoyl-CoA <=> 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.72", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658496", "l": "SIAH1:UBE2L6:Ubiquitin binds SNCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19793", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.5.8.3", "l": "\"sarcosine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983144", "l": "Transport of Antigen peptide in to ER (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53777", "l": "3-sulfanylpropanoate + O2 => 3-sulfinopropanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791088", "l": "Expression of GFPT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41678", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64517", "l": "2-hydroxyethane-1-sulfonate + NAD(+) => H(+) + NADH + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33042", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin <=> 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202394", "l": "Translocation of CARMA1 to Plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68082", "l": "a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+) => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68814", "l": "beta-bisabolene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46045", "l": "(3Z)-octenoyl-CoA => (2E)-octenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54773", "l": "ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-500708", "l": "GRIK3 homomer binds glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62435", "l": "a uridine in tRNA + S-adenosyl-L-methionine <=> a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11638", "l": "15-oxoprostaglandin E1 + H(+) + NADPH => NADP(+) + prostaglandin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693536", "l": "ATM phosphorylates MDC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48038", "l": "globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine => globoside Gb4Cer (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14982", "l": "NADP(+) + testosterone => androst-4-ene-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57248", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP = dGTP + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40549", "l": "2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin] => 10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050474", "l": "(S)-norcoclaurine synthase activity", "d": ["Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25800", "l": "H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173705", "l": "C5b binds C6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63276", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49891", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 <=> (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43356", "l": "cholesteryl (9Z,12Z)-octadecadienoate(in) = cholesteryl (9Z,12Z)-octadecadienoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28808", "l": "glutathione + H2O => L-cysteinylglycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60648", "l": "an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654425", "l": "Activated FGFR4 binds SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660557", "l": "RAS:GTP binds RAL GDS proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28754", "l": "sn-glycerol 3-phosphate + ubiquinone-8 <=> dihydroxyacetone phosphate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24068", "l": "cyclohexanone + H(+) + NADPH + O2 = H2O + hexano-6-lactone + NADP(+)", "d": []}, {"i": "EC:1.14.13.22", "l": "\"cyclohexanone monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52530", "l": "2-oxosuccinamate + L-glutamate => 2-oxoglutarate + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57476", "l": "dodecanoate + H2O2 = 2-hydroxydodecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50311", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18023", "l": "CMP + ganglioside GD1a (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.67", "l": "\"cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781922", "l": "USP13 binds UFD1L:SKP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54037", "l": "[mycoredoxin]-L-cysteine + arseno-mycothiol + H(+) => [mycoredoxin]-S-mycothiol-L-cysteine + arsenite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012205", "l": "Estrogen-responsive CHD1 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53727", "l": "ATP + N-acetyl-D-glucosamine <=> ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008752", "l": "FMN reductase (NAD(P)H) activity", "d": ["Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+. This reaction can utilize NADH and NADPH with similar reaction rates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-606287", "l": "RSF complex binds the centromere (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389919", "l": "Grb2 binds pBTLA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61594", "l": "3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine => H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48532", "l": "ganglioside GQ1c (d18:1(4E)) + H2O = ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18573", "l": "dihydrochelirubine + H(+) + O2 = chelirubine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45360", "l": "H2O + N-(11Z-eicosenoyl)-sphinganine = (11Z)-eicosenoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855375", "l": "PTPN22 dissociates from CSK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174551", "l": "Formation of alternative pathway C5 convertase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12098", "l": "benzylamine + formate => H2O + N-benzylformamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983150", "l": "Proteasomal cleavage of substrate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22580", "l": "(S)-4-hydroxy-2-oxopentanoate = (2Z)-2-hydroxypenta-2,4-dienoate + H2O", "d": []}, {"i": "EC:4.2.1.80", "l": "\"2-oxopent-4-enoate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57122", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21454", "l": "a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical => a [peptide]-C-terminal glycine + 2 L-ascorbate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46161", "l": "a quinone + H(+) + NADH => a quinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61135", "l": "(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + kaempferol + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49901", "l": "5,10-dihydrophenazine-1,6-dicarboxylate + O2 => H2O2 + phenazine-1,6-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625863", "l": "RETN gene expression is stimulated by FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052845", "l": "inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28658", "l": "glutathione S,S-dioxide + H2O <=> glutathione + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66331", "l": "taurine(out) <=> taurine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10706", "l": "AMP + diphosphate + L-valyl-tRNA(Val) => ATP + L-valine + tRNA(Val)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48126", "l": "ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate => ganglioside GD3 (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43308", "l": "1-hexadecanoyl-sn-glycerol + ATP = 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74602", "l": "AMP(out) + UDP-alpha-D-galactose(in) <=> AMP(in) + UDP-alpha-D-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "64.170973648324292", "identifiers": [{"i": "GO:0140993", "l": "histone modifying activity", "d": ["A catalytic activity that acts on a histone protein. Reversible histone modifications contribute to regulation of gene expression."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004977", "l": "melanocortin receptor activity", "d": ["Combining with melanocortin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47267", "l": "2,6,10,14-tetramethylpentadecanoate + ATP + CoA <=> AMP + diphosphate + pristanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19433", "l": "ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.12", "l": "\"gluconokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50905", "l": "L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61808", "l": "holo-[peptidyl-carrier protein] + L-alanyl-5'-AMP = AMP + H(+) + L-alanyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57666", "l": "alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-valencene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987214", "l": "p-STAT3 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662891", "l": "pheomelanin formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17454", "l": "5-phospho-beta-D-ribosylamine + ATP + glycine => ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32070", "l": "8-oxoguanine + H(+) + H2O <=> NH4(+) + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.98.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374337", "l": "Apelin receptor binds to apelin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913451", "l": "IL3RB is phosphorylated on Ser-585 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34420", "l": "(+)-lariciresinol + NADP(+) => (+)-pinoresinol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19988", "l": "NAD(+) + S-(hydroxymethyl)glutathione <=> H(+) + NADH + S-formylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69983", "l": "6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6-deoxoteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39573", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24730", "l": "anthranilate + H(+) = aniline + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197963", "l": "DHFR2 reduces FOLA to DHF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58135", "l": "A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] <=> AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21063", "l": "3,4-dichloroaniline + malonyl-CoA <=> CoA + N-(3,4-dichlorophenyl)malonamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72439", "l": "(E)-ferulate + ATP + H(+) = (E)-feruloyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69043", "l": "(2S)-2-nitrosobutanedioate + H(+) + NADPH + O2 <=> 2-nitrobutanedioate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75165", "l": "H(+) + NADP(+) + UDP => NAD(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0003906", "l": "DNA-(apurinic or apyrimidinic site) endonuclease activity", "d": ["Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58720", "l": "(S)-nicotine + NADPH + O2 = H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11329", "l": "dimethylallyl diphosphate + isopentenyl diphosphate => diphosphate + neryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42831", "l": "2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9770847", "l": "Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29500", "l": "(2E,6E)-farnesyl diphosphate => (+)-alpha-barbatene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48124", "l": "ganglioside GD3 (d18:1(4E)) + H2O = ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45052", "l": "(2E)-butenoyl-CoA + (R)-carnitine = CoA + O-(2E)-butenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34038", "l": "O2 + paromamine <=> 6'-oxoparomamine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33359", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0080161", "l": "auxin transmembrane transporter activity", "d": ["Enables the transfer of auxins from one side of a membrane to the other. Auxins are plant hormones that regulate aspects of plant growth."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54647", "l": "trans-4-hydroxy-L-proline <=> (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11822", "l": "H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide => diphthamide-[translation elongation factor 2] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59687", "l": "D-maltohexaose + O2 <=> D-maltohexaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418662", "l": "Src activation following P2Y purinoceptor activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41770", "l": "CMP + ganglioside GT1a (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034950", "l": "phenylboronic acid monooxygenase activity", "d": ["Catalysis of the reaction: phenylboronic acid + O2 + 2 H+ + 2 e- = phenol + B(OH)3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57240", "l": "glyoxal + GMP = N(2)-(1-hydroxy-2-oxoethyl)-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71517", "l": "hypoxanthine(in) => hypoxanthine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33011", "l": "(+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018838", "l": "mandelate racemase activity", "d": ["Catalysis of the reaction: (S)-mandelate = (R)-mandelate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228406", "l": "tetX HC transports tetX LC from target cell endosome membrane into cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5606996", "l": "Soluble PROCR binds activated protein C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201787", "l": "PPP3 complex dephosphorylates DARPP-32 on Thr34 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44151", "l": "L-lysine <=> D-beta-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029268", "l": "Phosphorylation and activation of PLCG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75431", "l": "32-hydroxyeburicol + O2 + reduced [NADPH--hemoprotein reductase] = 32-oxoeburicol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425861", "l": "Activation of Protein Kinase C novel isoforms (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15783", "l": "3-amino-3-(4-hydroxyphenyl)propanoate => L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41374", "l": "1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029690", "l": "Caspase-6 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16211", "l": "cob(II)yrinate => Co-precorrin-8X", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20413", "l": "glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine = glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.112", "l": "\"glucuronoxylan 4-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74222", "l": "H2O + L-seryl-tRNA(Thr) <=> L-serine + tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49633", "l": "(2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate => (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005158", "l": "insulin receptor binding", "d": ["Binding to an insulin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33407", "l": "ATP + glycine + H(+) = diphosphate + glycyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21691", "l": "a polyvinyl alcohol + n O2 <=> an oxidized polyvinyl alcohol + n H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56942", "l": "2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate => S-methyl-5-thio-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72982", "l": "didemethylasterriquinone D + dimethylallyl diphosphate <=> asterriquinone C1 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031854", "l": "orexigenic neuropeptide QRFP receptor binding", "d": ["Binding to an orexigenic neuropeptide QRFP receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46573", "l": "2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "45.965771232984629", "identifiers": [{"i": "GO:0022803", "l": "passive transmembrane transporter activity", "d": ["Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41171", "l": "1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O = 2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64838", "l": "CoA + phenethyl acetate => 2-phenylethanol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452102", "l": "p-STAT5 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36321", "l": "CoA + 2 NADP(+) + octadecan-1-ol => 2 H(+) + 2 NADPH + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010488", "l": "UDP-galactose:N-glycan beta-1,3-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-glycan = galactose-beta-1,3-N-glycan + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9644900", "l": "BDNF gene expression is stimulated by NPAS4:ARNT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29840", "l": "L-idonate + NADP(+) => 2-dehydro-L-idonate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.4", "l": "\"tripeptide aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58560", "l": "15alpha-stemmadenine intermediate II + NADP(+) = 15alpha-stemmadenine intermediate I + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47087", "l": "4-methylsulfanyl-2-oxobutanoate + L-tyrosine <=> 3-(4-hydroxyphenyl)pyruvate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36225", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41494", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.003741351937961", "identifiers": [{"i": "GO:0015145", "l": "monosaccharide transmembrane transporter activity", "d": ["Enables the transfer of a monosaccharide from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694428", "l": "LMAN family proteins bind glycosylated cargo (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865605", "l": "BRWD1 binds SMARCA4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12210", "l": "4-methylumbelliferone + acetate + H(+) => 4-methylumbelliferyl acetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13625", "l": "A + H2O + N(6)-dimethylallyladenine = 3-methyl-2-butenal + adenine + AH2", "d": []}, {"i": "EC:1.5.99.12", "l": "\"cytokinin dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31597", "l": "(Z)-2-methylaminoacrylate + carbamate + H(+) => (Z)-2-methylureidoacrylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63152", "l": "an N-fatty acyl-taurine + H2O = a fatty acid + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749609", "l": "BCHE hydrolyzes ASA- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047439", "l": "3-deoxy-D-manno-octulosonate aldolase activity", "d": ["Catalysis of the reaction: 3-deoxy-D-manno-octulosonate = D-arabinose + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928639", "l": "p-EFNB binds GRB4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29870", "l": "AMP + ITP <=> ADP + IDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36903", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.290", "l": "\"tRNA(Phe) [7-(3-amino-3-carboxypropyl)wyosine(37)-O]-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20160", "l": "a polyvinyl alcohol + 2n Fe(III)-[cytochrome c] <=> an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863727", "l": "STON2 is neddylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68914", "l": "DNA polymerase alpha:primase binds at the origin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043993", "l": "histone H3K18 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706328", "l": "Active FLT3 binds to SOCS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204773", "l": "Interaction of Tie2 and Grb7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67188", "l": "ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out) = ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38122", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58196", "l": "H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone]", "d": []}, {"i": "EC:3.5.1.98", "l": "\"histone deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9619355", "l": "CaMKK autophosphorylates in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10015", "l": "(R)-6-hydroxynicotine + H2O + O2 <=> 6-hydroxypseudooxynicotine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8957241", "l": "TP73 tetramer translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0070456", "l": "galactose-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: galactose-1-phosphate + H2O = galactose + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618328", "l": "ATAT acetylates microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41511", "l": "L-ornithine + NADPH + O2 <=> H2O + N(5)-hydroxy-L-ornithine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909721", "l": "Translocation of ISGF3 complex to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875451", "l": "MET phosphorylates CBL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59532", "l": "(S)-reticuline + S-adenosyl-L-methionine = (S)-codamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18452", "l": "A + arsenite + H2O <=> AH2 + arsenate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24412", "l": "4-(hydroxymethyl)benzenesulfonate + NAD(+) = 4-formylbenzenesulfonate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.257", "l": "\"4-(hydroxymethyl)benzenesulfonate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187332", "l": "Cytosolic CMs translocate to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951644", "l": "Release of mature NEDD8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65408", "l": "NAD(+)(in) = NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18140", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68615", "l": "Formation of ORC(1-6) complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31714", "l": "beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48258", "l": "(2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein] => (2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047574", "l": "4-acetamidobutyryl-CoA deacetylase activity", "d": ["Catalysis of the reaction: 4-acetamidobutanoyl-CoA + H2O = 4-aminobutanoyl-CoA + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71005", "l": "L-histidine(out) + L-phenylalanine(in) => L-histidine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45858", "l": "4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA => 3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51047", "l": "indole-3-pyruvate imine dimer <=> CO2 + NH4(+) + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69053", "l": "H(+) + N(omega)-methyl-L-arginine + 2 NADH + 3 O2 => 3 H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69748", "l": "(indol-3-yl)acetate + succinyl-CoA => (indol-3-yl)acetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12533", "l": "coenzyme B + methyl-coenzyme M => coenzyme M-coenzyme B heterodisulfide + methane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928641", "l": "PAK binds RAC and bPIX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59089", "l": "D-histidine + S-adenosyl-L-methionine => (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683488", "l": "ACE2 is glycosylated to glycosylated-ACE2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53461", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52098", "l": "9-hydroxy-octadecanoate + H(+) + octadecanoate => 9-octadecanoyloxy-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36469", "l": "glycine + L-alanine => H2O + L-alanylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953037", "l": "E2F8 forms homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13431", "l": "4-CDP-2-C-methyl-D-erythritol + diphosphate => 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679205", "l": "ULK1 phosphorylates Beclin-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48715", "l": "2 Fe(2+) + 2 H(+) + H2O2 <=> 2 Fe(3+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1006169", "l": "Factor H binds host cell surface markers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39819", "l": "docosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2-hydroxydocosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49582", "l": "cyclic pyranopterin phosphate + diphosphate => (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865994", "l": "GAB1 binds PTPN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1467466", "l": "ABCA4 mediates atRAL transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42725", "l": "guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130151", "l": "Dimerization of DAP12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.348", "l": "\"(3R)-2'-hydroxyisoflavanone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60751", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone <=> CoA + pyrethrin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68917", "l": "ATP + butanoate + H(+) + NADPH => AMP + butanal + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38727", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047913", "l": "gallate 1-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: gallate + UDP-D-glucose = 1-O-galloyl-beta-D-glucose + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624800", "l": "CDK1 phosphorylates LBR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27585", "l": "(S)-2-hydroxymethylglutarate <=> 2-methyleneglutarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052806", "l": "sulfite reductase (coenzyme F420) activity", "d": ["Catalysis of the reaction: sulfite + 3 1,5-dihydrocoenzyme F420 = hydrogen sulfide + 3 H2O + 3 coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37827", "l": "(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65291", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9681294", "l": "IL6R binds IL6R inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64127", "l": "H2O + N-hexadecanoyl-L-phenylalanine <=> hexadecanoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23449", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP => CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62491", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453183", "l": "p-Y348-SYK dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-419644", "l": "Transphosphorylation of pLIMK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38808", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39974", "l": "1-aminocyclopropane-1-carboxylate <=> 2-aminobut-2-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140440", "l": "protein-cysteine S-oleoyltransferase activity", "d": ["Catalysis of the transfer of an oleoyl (systematic name, (9Z)-octadecenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: (9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]."]}, {"i": "RHEA:59744", "l": "(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20781", "l": "ATP + GMP => ADP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18298", "l": "a phtalamide + H2O => a primary amine + phthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22540", "l": "5'-dehydroadenosine + H2O + O2 = 9-riburonosyladenine + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3782637", "l": "HDAC8 deacetylates histones (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58858", "l": "(6E)-8-oxogeraniol + H(+) + NADH => (6E)-8-hydroxygeraniol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31717", "l": "11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61230", "l": "3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+) => H2O + L-histidine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20852", "l": "ATP + H(+)(in) + H2O = ADP + 2 H(+)(out) + phosphate", "d": []}, {"i": "EC:7.1.2.1", "l": "\"P-type H(+)-exporting transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69306", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+) => (Z)-glucotropeolin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70722", "l": "L-alanine(in) <=> L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798257", "l": "PTPRS binds NTRK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30298", "l": "GTP + pyruvate <=> GDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451283", "l": "kainate receptor binds glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12045", "l": "a triacylglycerol + H2O => a diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0005287", "l": "high-affinity basic amino acid transmembrane transporter activity", "d": ["Enables the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64188", "l": "an N-(fatty acyl)-L-tyrosine + H2O = a fatty acid + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "59.868753869559903", "identifiers": [{"i": "GO:0140657", "l": "ATP-dependent activity", "d": ["A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191830", "l": "snRNP nuclear import and release (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218805", "l": "PKC autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051034", "l": "tRNA transmembrane transporter activity", "d": ["Enables the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173769", "l": "RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16787", "l": "an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50576", "l": "acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102413", "l": "6-O-methyl-deacetylisoipecoside beta-glucosidase activity", "d": ["Catalysis of the reaction: 6-O-methyl-N-deacetylisoipecoside + H2O <=> 6-O-methyl-N-deacetylisoipecoside aglycon + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022315", "l": "MECP2 binds DGCR8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139952", "l": "Caspase-8 processing in the DISC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810392", "l": "TMEM55B translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67006", "l": "a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate => a 5'-end triphospho-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36663", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA = (2S,5S)-5-carboxymethylproline + CO2 + CoA", "d": []}, {"i": "EC:2.3.1.226", "l": "\"carboxymethylproline synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71224", "l": "chloride(out) + 2 Na(+)(out) + taurine(out) => chloride(in) + 2 Na(+)(in) + taurine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43005", "l": "H(+) + O-carbamoyl-L-serine => 2-aminoprop-2-enoate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912790", "l": "CBL binds CRK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64592", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10301", "l": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate => (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68626", "l": "(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit] => phycoerythrobilin-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061776", "l": "topological DNA co-entrapment activity", "d": ["A DNA binding activity in which a protein complex interacts with more than one DNA duplex to encircle the DNA molecules with a loose fitting ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169406", "l": "ISGylation of host proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69181", "l": "ADP + thiamine diphosphate => AMP + thiamine triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804383", "l": "PRMT5 methylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614544", "l": "Sulfite is oxidized to sulfate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16226", "l": "1,8-diazacyclotetradecane-2,9-dione + H2O => N-(6-aminohexanoyl)-6-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15487", "l": "cis-homoaconitate + H2O => (2R,3S)-homoisocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034920", "l": "pyrene dioxygenase activity", "d": ["Catalysis of the reaction: pyrene + 2 H+ + 2 e- + O2 = cis-4,5-dihydroxy-4,5-dihydropyrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429497", "l": "SLP-76 stimulates PLC gamma 2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658574", "l": "PARK2 binds SNCAIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682863", "l": "RNF168 binds DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114684", "l": "Phosphorylation of Syntaxin-4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50208", "l": "cortisol + NAD(+) = cortisone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22219", "l": "(E)-caffeate + O2 <=> 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56260", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose = 4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-190141", "l": "ALAD binds to Pb2+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12060", "l": "acetyl-CoA + 5 H(+) + 6 malonyl-CoA = 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51579", "l": "phloretin + UDP-alpha-D-glucose <=> H(+) + phlorizin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2423785", "l": "CR:atREs binds apoE and HSPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050553", "l": "taxadiene synthase activity", "d": ["Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11879", "l": "NAD(+) + prostaglandin E2 <=> 15-oxoprostaglandin E2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75660", "l": "(11Z,14Z)-eicosadienoate + O2 => 12-hydroperoxy-(10E,14Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022365", "l": "GRIA2 gene expression is inhibited by MECP2:SIN3A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70350", "l": "bromide + L-tyrosine + NADP(+) <=> 3-bromo-L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44800", "l": "1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+) = 2-demethylmenaquinol-6 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71488", "l": "H2O + Leu-enkephalin => L-phenylalanyl-L-leucine + L-tyrosylglycylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709317", "l": "CO binds to free ferrohemoglobin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047826", "l": "D-lysine 5,6-aminomutase activity", "d": ["Catalysis of the reaction: D-lysine = 2,5-diaminohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35560", "l": "H(+) + menaquinone-7 + NADH => menaquinol-7 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31371", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine = (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.212", "l": "\"2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611851", "l": "ADRB2 bind ADR,NAd (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199299", "l": "AKT phosphorylates FOXO transcription factors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169394", "l": "ISGylation of IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444476", "l": "FPRL2 receptor binds a wide range of ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73775", "l": "dimethylallyl diphosphate + preechinulin = diphosphate + tardioxopiperazine B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60468", "l": "3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726875", "l": "HCNs:cAMP bind SNIs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66438", "l": "H(+) + NADPH + pent-1-en-3-one => NADP(+) + pentan-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53250", "l": "7-oxocholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45826", "l": "CO2 + ethanolamine => H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865547", "l": "RUNX1:CBFB binds FOXP3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806613", "l": "Keratin tetramers bind to form unit length filaments (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32752", "l": "choline(out) => choline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56839", "l": "[PQQ precursor protein] + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204364", "l": "ROBO1 binds SLIT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21714", "l": "benzaldehyde + glycine => L-threo-3-phenylserine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0060229", "l": "lipase activator activity", "d": ["Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5660660", "l": "p300 acetylates RELA subunit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372425", "l": "fructose 2,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800797", "l": "The PIDDosome activates CASP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51627", "l": "formate + GTP + H(+) <=> CO2 + dGTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987223", "l": "IL10RB binds TYK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358790", "l": "RNF41 ubiquitinates ERBB3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40517", "l": "(2S)-3-sulfolactaldehyde + dihydroxyacetone phosphate => 6-deoxy-6-sulfo-D-fructose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43354", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol(out) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57463", "l": "(E)-sinapyl alcohol + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64520", "l": "acetyl-CoA + AH2 + 3 H(+) + 3 malonyl-CoA = A + 3 CO2 + 4 CoA + H2O + orsellinaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.78", "l": "\"GPR endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14262", "l": "(E)-sinapoyl-CoA + D-glucono-1,5-lactone => 6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985153", "l": "OASL binds DDX58 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050590", "l": "desacetoxyvindoline 4-hydroxylase activity", "d": ["Catalysis of the reaction: desacetoxyvindoline + 2-oxoglutarate + O2 = desacetylvindoline + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62557", "l": "3,4-dihydroxyphenylacetate + H(+) => 4-methylcatechol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5631941", "l": "SESN1,2,3 bind AMPK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40777", "l": "D-alpha-phenylglycine + NH4(+) => 2-amino-2-phenylacetonitrile + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58785", "l": "2-oxoglutarate + a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 => a 5'-end triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18306", "l": "acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-4-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168888", "l": "Alpha1-Microglobulin binds heme (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73785", "l": "diphosphate + echinulin => dimethylallyl diphosphate + tardioxopiperazine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40838", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O <=> 2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029460", "l": "PAK1 phosphorylates LIMK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67737", "l": "N-acetyl-alpha-neuraminate => aceneuramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627089", "l": "CASP9 is phosphorylated at T412 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47025", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O => [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57340", "l": "3-hydroxy-L-kynurenine + S-adenosyl-L-methionine = 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877918", "l": "RUNX2:MAF complex binds the BGLAP gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11477", "l": "glycerol 1-phosphate + H2O => glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035643", "l": "L-DOPA receptor activity", "d": ["Combining with L-DOPA to initiate a change in cell activity. L-DOPA is the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid, and is the precursor to dopamine, norepinephrine (noradrenaline) and epinephrine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34361", "l": "a 2-acylglycerol + a carboxylate + H(+) => a 1,2-diacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38396", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O => (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43286", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061929", "l": "gamma-glutamylaminecyclotransferase activity", "d": ["Catalysis of the reaction: epsilon-(L-gamma-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58546", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-tetradecanoylglycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36700", "l": "3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP => 8-desmethylnovobiocic acid + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0009881", "l": "photoreceptor activity", "d": ["The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63215", "l": "5-amino-6-(D-ribitylamino)uracil + methylglyoxal <=> 5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636304", "l": "Mce3E binds MAPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875531", "l": "MET binds TNS4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75598", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> 11-hydroxy-12,13-epoxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53734", "l": "2-hydroxy-7,8-dihydropteroate + diphosphate => (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49576", "l": "AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": []}, {"i": "EC:4.1.99.22", "l": "\"GTP 3',8-cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1369028", "l": "ABCAs mediate lipid efflux (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56039", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55320", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016362", "l": "activin receptor activity, type II", "d": ["Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor."]}, {"i": "REACT:R-HSA-201443", "l": "Type II receptor phosphorylates type I receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72036", "l": "ATP(out) + 2 H(+)(out) + phosphate(in) => ATP(in) + 2 H(+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63772", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033192", "l": "calmodulin-dependent protein phosphatase activity", "d": ["Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810843", "l": "Envoplakin binds periplakin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22426", "l": "an alkyl thiol + NH4(+) + pyruvate => an S-alkyl-L-cysteine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69294", "l": "goitrin + sulfate => (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824222", "l": "HES7 binds the HES7 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75860", "l": "all-trans-4-hydroxy-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-4-oxo-13,14-dihydroretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604308", "l": "NICD4 traffics to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635868", "l": "ub-GLI is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66267", "l": "ATP + H(+) + nonanoate <=> diphosphate + nonanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.510429476229447", "identifiers": [{"i": "GO:0005372", "l": "water transmembrane transporter activity", "d": ["Enables the transfer of water (H2O) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32347", "l": "2 S-adenosyl-L-methionine + tricetin = 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.175", "l": "\"tricin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16890", "l": "2-oxoglutarate + 6-acetamido-3-aminohexanoate => 6-acetamido-3-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59177", "l": "ADP + L-serine => AMP + H(+) + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24235", "l": "2-dehydro-3-deoxy-D-gluconate + NAD(+) <=> 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016087", "l": "ecdysiostatic hormone activity", "d": ["The action characteristic of ecdysiostatic hormone, a peptide hormone that inhibits ecdysone secretion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69905", "l": "cytidine(in) + 2 Na(+)(in) => cytidine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169895", "l": "Crk's SH3 domain engages C3G (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55410", "l": "[phosphate](n+1) + CDP => [phosphate](n) + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32625", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => L-threo-tetrahydrobiopterin + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033164", "l": "glycolipid 1,6-alpha-mannosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67197", "l": "H2O + N-acetylserotonin => acetate + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54334", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24435", "l": "H2O + oxaloacetate <=> acetate + H(+) + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2077420", "l": "FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59186", "l": "2-acetylphloroglucinol + acetate => 2,4-diacetylphloroglucinol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016152", "l": "mercury (II) reductase activity", "d": ["Catalysis of the reaction: H+ + Hg + NADP+ = Hg2+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15157", "l": "4-hydroxyphenylacetate + H(+) + NADPH + O2 = H2O + homogentisate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340226", "l": "CYGB dioxygenates NO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45076", "l": "(9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] = (9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202222", "l": "Phosphorylation of PKC theta (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66550", "l": "4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate => 3'-phosphoadenylyl sulfate + 4-nitrophenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.25", "l": "\"(d)CMP kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018723", "l": "3-phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: 3-phenanthrol + X-SO3(-) = HX + 3-phenanthrylsulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132284", "l": "Formation of C5b:C6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50786", "l": "(2E)-dodecenal + H(+) + NADPH => dodecanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69952", "l": "3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydroteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875568", "l": "RAPGEF1 activates RAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781922", "l": "USP13 binds UFD1L:SKP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58945", "l": "6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH => 7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67691", "l": "2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O <=> 2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042013", "l": "interleukin-19 binding", "d": ["Binding to interleukin-19."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.63", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202248", "l": "Phosphorylation of PLC-gamma1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34735", "l": "a fatty acyl-CoA + sphinganine = an N-acylsphinganine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53927", "l": "a secondary amine + S-adenosyl-L-methionine <=> a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65371", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O <=> a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047638", "l": "albendazole monooxygenase activity", "d": ["Catalysis of the reaction: albendazole + H+ + NADPH + O2 = albendazole S-oxide + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865275", "l": "PDGF-BB clevage by Furin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51313", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73554", "l": "GDP(out) + UTP(in) <=> GDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209925", "l": "DIT and MIT combine to form triiodothyronine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19216", "l": "acetyl-CoA + an S-substituted L-cysteine <=> an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2077424", "l": "Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33348", "l": "2-iminoacetate + H2O => glyoxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416516", "l": "GRK2 sequesters activated Gq (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50076", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419841", "l": "Light stimulates opsin receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609310", "l": "β-blockers bind ADRB1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44210", "l": "12-methyltridecanoyl-CoA + AMP + diphosphate => 12-methyltridecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20721", "l": "H2O + isopenicillin N + phenylacetyl-CoA => CoA + H(+) + L-2-aminoadipate + penicillin G", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11568", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP = 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate", "d": []}, {"i": "EC:2.1.1.54", "l": "\"deoxycytidylate C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247497", "l": "ERBB3 binds neuregulins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56570", "l": "globoside IV3GalNAc-Gb4Cer + H(+) + UDP => globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102453", "l": "anthocyanidin 3-O-glucoside 6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + H+ + an anthocyanidin-3-O-beta-D-glucoside = coenzyme A + H+ + an anthocyanidin-3-O-[6-O-(hydroxycinnamoyl)-beta-D-glucoside]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43997", "l": "2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2 => a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429449", "l": "Syk activation leads to SLP-76 activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13511", "l": "diphosphate + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24987", "l": "(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5226999", "l": "ADD1:ADD3 binds DMTN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64436", "l": "glycylglycyl-L-isoleucine(out) + H(+)(out) = glycylglycyl-L-isoleucine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13152", "l": "A + H(+) + NADPH <=> AH2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36521", "l": "3-oxooctacosanyol-CoA + CO2 + CoA => H(+) + hexacosanoyl-CoA + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72053", "l": "butanoate(in) + estrone 3-sulfate(out) => butanoate(out) + estrone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112430", "l": "Formation of P-TEFb complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682388", "l": "Autophagosome maturation (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46084", "l": "H2O + sn-glycerol 1-phosphate = glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36828", "l": "dioscin + 3 H2O => D-glucose + diosgenin + 2 L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610752", "l": "GLI3R translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.16", "l": "\"steroid 21-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017096", "l": "acetylserotonin O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68613", "l": "H(+) + NADPH + prostaglandin E1 => NADP(+) + prostaglandin F1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616368", "l": "MyrG-CDK5R1,2 bind CDK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11191", "l": "3-cyano-L-alanine + 2 H2O <=> L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58046", "l": "2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA => a long-chain fatty acyl-CoA + alpha,alpha-trehalose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865994", "l": "GAB1 binds PTPN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71849", "l": "LDH tetramer reduces PYR to LACT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37635", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32628", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653957", "l": "Rag dimer formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28173", "l": "(2R)-2-hydroxy-2-methylbutanenitrile <=> butan-2-one + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20812", "l": "(3S)-citryl-CoA = acetyl-CoA + oxaloacetate", "d": []}, {"i": "EC:4.1.3.34", "l": "\"citryl-CoA lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19888", "l": "(S)-reticuline + O2 <=> (S)-scoulerine + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174171", "l": "Association of Cyclin A with the APC/C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371554", "l": "HSF1 acetylation at Lys80 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186778", "l": "SHP2 binds to the active receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57398", "l": "3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine => (S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54763", "l": "ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide <=> 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18989", "l": "H(+) + L-valine = 2-methylpropan-1-amine + CO2", "d": []}, {"i": "EC:4.1.1.14", "l": "\"valine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022911", "l": "CSPG is secreted (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47217", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33664", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44625", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.112", "l": "\"site-1 protease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52631", "l": "an N-fatty-acyl-L-alpha-amino acid + H2O <=> a fatty acid + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9737780", "l": "MTTP binds lomitapide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32547", "l": "(2E)-geranyl diphosphate = (1R,5R)-sabinene + diphosphate", "d": []}, {"i": "EC:4.2.3.110", "l": "\"(+)-sabinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32291", "l": "phosphoethanolamine + 3 S-adenosyl-L-methionine = 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.9", "l": "\"trypanothione synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52573", "l": "butanoyl-CoA + NAD(+) => (2E)-butenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218814", "l": "PAK2 autophorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45477", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.240751554780076", "identifiers": [{"i": "GO:0120013", "l": "lipid transfer activity", "d": ["Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60215", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70071", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sitosterol = (22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047384", "l": "[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity", "d": ["Catalysis of the reaction: H2O + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate = phosphate + [hydroxymethylglutaryl-CoA reductase (NADPH)]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717841", "l": "holo-FDPS dimer binds NBPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68611", "l": "H(+) + isatin + NADPH <=> 3-hydroxyindolin-2-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57964", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.168", "l": "\"germacreene A acid 8beta-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31214", "l": "ATP + H2O + L-selenomethionine <=> diphosphate + L-adenosylselenomethionine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55969", "l": "(+)-kolavelool + S-adenosyl-L-methionine => (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47517", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isochenodeoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65567", "l": "(9Z)-octadecenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67317", "l": "(2S,4R)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine => (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69985", "l": "3-dehydro-6-deoxoteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28493", "l": "H(+)(in) + K(+)(in) <=> H(+)(out) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014456", "l": "GDIs block activation of RHOG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602484", "l": "Activation of proMMP11 by FURIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52687", "l": "NAD(+) + pyridoxine <=> H(+) + NADH + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77081", "l": "Formation of the CE:GMP intermediate complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62036", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432946", "l": "PARVB/Affixin interacts with alpha PIX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380294", "l": "Loss of C-Nap-1 from centrosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008859", "l": "exoribonuclease II activity", "d": ["Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619667", "l": "PRX gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.75", "l": "\"3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36877", "l": "3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA => (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606288", "l": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419351", "l": "PAF receptor binds platelet activating factor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68165", "l": "N-(8'-hydroxygeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + N-(8'-oxogeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714481", "l": "RAC2 binds effectors at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140728", "l": "GC-box binding", "d": ["Binding to a GC-box, a DNA motif with the consensus sequence GGGCGG that is located upstream of the start point of eukaryotic transcription units. The GC-box may occur in multiple copies or in either orientation relative to the transcription start site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785594", "l": "FANCD2 binds FANCI (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451033", "l": "(S)-Malate <=> Fumarate + H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73664", "l": "(E,E)-piperoyl-CoA + pyrrolidine => CoA + H(+) + piperyline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21794", "l": "acetone + H(+) + NADPH => NADP(+) + propan-2-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24078", "l": "a 3-oxo-Delta(5)-steroid + H(+) + NADH => a 3beta-hydroxy-Delta(5)-steroid + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43265", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA => 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48470", "l": "ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GM1b (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.182", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69710", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphinganine + H2O <=> beta-D-galactose + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6795473", "l": "PDPK1 phosphorylates SGK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59173", "l": "hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] => AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64097", "l": "3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] => 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389354", "l": "Activation of Vav1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.240751554780076", "identifiers": [{"i": "GO:0008131", "l": "primary amine oxidase activity", "d": ["Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28563", "l": "D-alanine + pyridoxal 5'-phosphate => pyridoxamine 5'-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0051002", "l": "ligase activity, forming nitrogen-metal bonds", "d": ["Catalysis of the joining of a metal ion to a molecule via a nitrogen-metal bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}, {"i": "EC:6.6.-.-", "l": "\"Forming nitrogen-metal bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051777", "l": "ent-kaurenoate oxidase activity", "d": ["Catalysis of the reaction: ent-kaurenoate + NADPH + O2 = ent-7-alpha-hydroxykaurenoate + NADP+ + H2O. This is the first of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0061785", "l": "peptidoglycan endopeptidase activity", "d": ["An endopeptidase activity that uses peptidoglycan as a substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67212", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + O2 = (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20625", "l": "2 Fe(III)-[cytochrome c3] + H2 = 2 Fe(II)-[cytochrome c3] + 2 H(+)", "d": []}, {"i": "EC:1.12.2.1", "l": "\"cytochrome-c3 hydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53553", "l": "(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40807", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018746", "l": "RHOQ binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29497", "l": "beta-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11658", "l": "AMP + diphosphate + L-prolyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19998", "l": "H2O + phosphoenolpyruvate => phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0070279", "l": "vitamin B6 binding", "d": ["Binding to a vitamin B6 compound: pyridoxal, pyridoxamine, pyridoxine, or the active form, pyridoxal phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74136", "l": "petunidin + UDP-alpha-D-galactose => petunidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001965", "l": "G-protein alpha-subunit binding", "d": ["Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33510", "l": "sphing-4-enine 1-phosphate <=> (2E)-hexadecenal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0003993", "l": "acid phosphatase activity", "d": ["Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16420", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) <=> H(+) + L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205289", "l": "Autophosphorylation of KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047793", "l": "cycloeucalenol cycloisomerase activity", "d": ["Catalysis of the reaction: cycloeucalenol = obtusifoliol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73932", "l": "Resynthesis of excised residue by POLB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55632", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373075", "l": "Metabotropic glutamate receptors bind glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187828", "l": "Translocation of p21 to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28671", "l": "2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57608", "l": "(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-chlorocatechol + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.119", "l": "\"chlorobenzene dihydrodiol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72691", "l": "Formation of the 43S pre-initiation complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849882", "l": "SALMs 1-4 bind reticulon 3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28050", "l": "H2O + NADP(+) = NAD(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16893", "l": "pyridine + S-adenosyl-L-methionine = N-methylpyridinium + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.87", "l": "\"pyridine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030768", "l": "16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + deacetoxyvindoline + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41536", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine = 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.303", "l": "\"2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0035757", "l": "chemokine (C-C motif) ligand 19 binding", "d": ["Binding to chemokine (C-C motif) ligand 19."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868666", "l": "CDK5:p25 phosphorylates JUN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29343", "l": "L-aspartate(in) + succinate(out) = L-aspartate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114671", "l": "vWF binds to collagen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67093", "l": "ATP + docosanoate(in) + H2O => ADP + docosanoate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59002", "l": "H(+) + H2O2 + propanoate => H2O + O2 + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73849", "l": "17alpha-sitoindoside IX + H(+) + UDP => 17alpha-hydroxywithaferin A + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416929", "l": "PTGFR binds PGF2a (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37512", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9688459", "l": "RIPK3 binds HSP90:CDC37 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71257", "l": "3 Na(+)(in) + phosphate(in) => 3 Na(+)(out) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35722", "l": "(3S)-versiconol acetate + H2O <=> (S)-versiconol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57943", "l": "Fe-coproporphyrin III + H(+) + H2O2 <=> CO2 + 2 H2O + harderoheme III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38215", "l": "D-glucose 6-phosphate + NAD(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23744", "l": "2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate", "d": []}, {"i": "EC:2.6.1.9", "l": "\"histidinol-phosphate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19794", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56896", "l": "a carboxylate + ATP + H(+) = an acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350467", "l": "GUG binds to FT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.27", "l": "\"cyclopenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57567", "l": "(+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814387", "l": "CASP14 cleaves filaggrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15997", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADH + O2 = 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483087", "l": "PI is exchanged with PC by PITPNB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44702", "l": "a (2E)-enoyl-CoA + FADH2 => a 2,3-saturated acyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59562", "l": "H(+) + N,N',N''-triacetylchitotrionate => H2O + N,N',N''-triacetylchitotriono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67602", "l": "diphosphate + H(+) + O(6)-methyl-dGMP => H2O + O(6)-methyl-dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371554", "l": "HSF1 acetylation at Lys80 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.58", "l": "\"glucan 1,3-beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56943", "l": "S-methyl-5-thio-D-ribulose 1-phosphate <=> 2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804955", "l": "ATM phosphorylates MDM2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731274", "l": "nsp16 localizes to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69543", "l": "GTP + streptomycin <=> 6-O-guanylylstreptomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30124", "l": "H2O + tetradecanoyl-[ACP] => H(+) + holo-[ACP] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174438", "l": "Formation of the Flap Intermediate on the C-strand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14258", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65715", "l": "alpha-D-glucose 1-phosphate + GDP-beta-L-galactose <=> beta-L-galactose 1-phosphate + GDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11381", "l": "2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2 => [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72540", "l": "3,4-dihydroxybenzaldehyde + H2O + NADP(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15680", "l": "5-aminopentanamide + H2O <=> 5-aminopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038121", "l": "C-C motif chemokine 21 receptor activity", "d": ["Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40062", "l": "decanoyl-CoA + H2O <=> CoA + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67549", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O => [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701064", "l": "TRPV1 binds TRPV1 agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27514", "l": "H2O + sphinganine 1-phosphate = phosphate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76052", "l": "(S)-scoulerine + S-adenosyl-L-methionine => (S)-cis-N-methylscoulerine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12801", "l": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42644", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] = diphosphate + holo-[malonate decarboxylase ACP]", "d": []}, {"i": "EC:2.7.7.66", "l": "\"malonate decarboxylase holo-[acyl-carrier protein] synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388814", "l": "Grb2 binds CD28 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853890", "l": "VENTX binds the IL6 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16279", "l": "(indol-3-yl)acetate + H(+) + H2O2 => H2O + indole-3-acetaldehyde + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41699", "l": "1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69127", "l": "Formation of the Flap Intermediate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039556", "l": "MDA-5 binding", "d": ["Binding to MDA-5, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5622129", "l": "FABP5 binds atRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17810", "l": "Mg-protoporphyrin IX + S-adenosyl-L-methionine => Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689544", "l": "UCHL5 binds INO80 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55357", "l": "11-cis-retinol => 13-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13058", "l": "an N-acylneuraminate 9-phosphate + H2O => an N-acylneuraminate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60675", "l": "NAD(+) + nerol <=> H(+) + NADH + neral", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45313", "l": "NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.15", "l": "\"D-iditol 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30687", "l": "(4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60407", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102200", "l": "N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity", "d": ["Catalysis of the reaction: H2O + an N-acylphosphatidylethanolamine = H+ + an N-acylethanolamine + a 1,2-diacyl-sn-glycerol 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429529", "l": "Thrombin binding to GP1b:IX:V (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43599", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 <=> 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001108", "l": "bacterial-type RNA polymerase holo enzyme binding", "d": ["Binding to a component of the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12174", "l": "beta-D-fructose 6-phosphate + NH4(+) => alpha-D-glucosamine 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48326", "l": "ganglioside Fuc-GD1b + GDP + H(+) => ganglioside GD1b + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52624", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate = [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.60", "l": "\"glutamate--[amino group carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.71", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15993", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 = 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613497", "l": "Unwinding DNA for the nascent transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693608", "l": "Initial resection of double-strand break ends (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36106", "l": "anthranilate + S-adenosyl-L-methionine <=> O-methyl anthranilate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31493", "l": "H(+) + soyasaponin I + UDP => soyasaponin III + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19777", "l": "A + L-pipecolate = AH2 + H(+) + L-1-piperideine-6-carboxylate", "d": []}, {"i": "EC:1.5.99.3", "l": "\"L-pipecolate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395340", "l": "Formation of hydroxyallysine by LOX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010437", "l": "9,10 (9', 10')-carotenoid-cleaving dioxygenase activity", "d": ["Catalysis of the oxidative cleavage of carotenoids at the (9, 10) and/or (9', 10') double bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62247", "l": "a cytidine(6-4)thymidine in DNA <=> a cytidine-thymine dinucleotide in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210298", "l": "Interaction of DAP12 and KIR3DS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55113", "l": "4-methyl-3-oxopentanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50639", "l": "a 3-(omega-methylsulfanyl)alkylmalate <=> a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65359", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72298", "l": "malate(out) + 3 Na(+)(out) <=> malate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18326", "l": "(2E,6E)-farnesyl diphosphate => (+)-amorpha-4,11-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9716160", "l": "SARS-CoV-2 M protein binds MAVS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44375", "l": "Cr(6+) + 2 NADH + O2 <=> Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68005", "l": "AH2 + chloroethene => A + chloride + ethene + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950782", "l": "p-STAT1 binds p-STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23647", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373734", "l": "Nephrin interacts with Podocin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46289", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55266", "l": "di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30587", "l": "2-demethylmenaquinol-8 + dimethyl sulfoxide = 2-demethylmenaquinone-8 + dimethyl sulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70236", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol => an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561072", "l": "OCT3 mediates renal uptake of organic cations (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141341", "l": "SMOX-3 oxidises SPN to SPM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005302", "l": "L-tyrosine transmembrane transporter activity", "d": ["Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59605", "l": "H2O + O2 + spermidine => H2O2 + N-(4-aminobutyl)-3-aminopropanal + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29150", "l": "2 H(+)(in) + nitrate + ubiquinol-8 <=> 2 H(+)(out) + H2O + nitrite + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33462", "l": "H(+) + NADPH + zymosterone <=> NADP(+) + zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26078", "l": "methanesulfonate + NADH + O2 => formaldehyde + H2O + NAD(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202233", "l": "Inactivation of Lck by Csk (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31629", "l": "10-deoxymethymycin + dTDP + H(+) => 10-deoxymethynolide + dTDP-alpha-D-desosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29065", "l": "a menaquinol + CO2 => a menaquinone + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40422", "l": "H2O + phytanoyl-CoA <=> 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023461", "l": "MECP2 T158A:SIN3A complex does not bind BDNF gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2574845", "l": "AJUBA binds centrosome-associated AURKA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25072", "l": "3-hydroxybenzoyl-CoA + AMP + diphosphate => 3-hydroxybenzoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25784", "l": "2-dehydro-3-deoxy-L-rhamnonate = (S)-lactaldehyde + pyruvate", "d": []}, {"i": "EC:4.1.2.53", "l": "\"2-keto-3-deoxy-L-rhamnonate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204485", "l": "Basigin binds CyPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086039", "l": "P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential", "d": ["A calcium-transporting P-type ATPase activity involved in regulation of the plasma membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28582", "l": "ATP + dUDP = ADP + dUTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70791", "l": "H(+)(in) + L-ornithine(out) = H(+)(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875661", "l": "GGA3 associates with activated MET receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102925", "l": "solanine UDP-galactose galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-galactose + solanidine = H+ + gamma-solanine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66311", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose <=> an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29621", "l": "alpha-maltopentaose + beta-D-glucose => alpha-maltotetraose + beta-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28154", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211219", "l": "Translocation of caspase-3 to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12064", "l": "5-oxopentanoate + H2O + NAD(+) = glutarate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180017", "l": "K11-linked deubiquitinase activity", "d": ["Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys11 residue of ubiquitin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211193", "l": "Homodimerization  of DFF40 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76386", "l": "CYP1A2 S-demethylates 6MMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49880", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9032798", "l": "DOCK3 activates RAC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624949", "l": "Assembly of the anterograde IFT train (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173626", "l": "Activation of C1r (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19407", "l": "(3S)-citryl-CoA + acetate => acetyl-CoA + citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43171", "l": "adenosine(34) in tRNA + H(+) + H2O <=> inosine(34) in tRNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11257", "l": "H2O + limonin + UDP-alpha-D-glucose => glucosyl-limonin + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45738", "l": "(2E)-hexenoyl-CoA => (3E)-hexenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.193", "l": "\"ginsenosidase type I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050219", "l": "prostaglandin-A1 delta-isomerase activity", "d": ["Catalysis of the reaction: prostaglandin A1 = prostaglandin C1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202960", "l": "Caspase mediated cleavage of C-IAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199131", "l": "PVR binds CD226 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40742", "l": "(20S)-ginsenoside Rb2 + 2 H2O <=> (20S)-ginsenoside C-Y + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112727", "l": "Serine phosphorylation of STATs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65742", "l": "CO2 + H(+) + nonanal + succinate + sulfate => 2-oxoglutarate + nonyl sufate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433488", "l": "Phosphorylation of SHP2 by SFKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0070529", "l": "L-tryptophan aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from L-tryptophan to an acceptor, usually a 2-oxo acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-912727", "l": "CBL binds VAV (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38395", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34055", "l": "festuclavine + NAD(+) = 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH", "d": []}, {"i": "EC:1.5.1.44", "l": "\"festuclavine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26507", "l": "(9Z)-octadecenamide + H2O => (9Z)-octadecenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013109", "l": "RHOC GEFs activate RHOC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-741411", "l": "CYLD deubiquitinates NEMO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14771", "l": "(S)-6-hydroxynicotine + AH2 => (S)-nicotine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56400", "l": "[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9671145", "l": "DKC1 binds SHQ1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75336", "l": "bromide(in) + chloride(out) => bromide(out) + chloride(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0098847", "l": "sequence-specific single stranded DNA binding", "d": ["Binding to single-stranded DNA of a specific nucleotide composition."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24360", "l": "2 H(+) + siroheme = Fe(2+) + sirohydrochlorin", "d": []}, {"i": "EC:4.99.1.4", "l": "\"sirohydrochlorin ferrochelatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44576", "l": "4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) = 2-all-trans-nonaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936665", "l": "OPS is added to the carrier sulfide (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879459", "l": "F-actin capping protein is a heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019002", "l": "GMP binding", "d": ["Binding to GMP, guanosine monophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2537499", "l": "Gelatin degradation by MMP19 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140347", "l": "N-retinylidene-phosphatidylethanolamine flippase activity", "d": ["Catalysis of the movement of N-retinylidene-N-retinylphosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49414", "l": "alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+) => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944214", "l": "Association of procollagen type I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674095", "l": "PDGFRs bind type II TKI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67290", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + AMP + 8 CO2 + 8 CoA + diphosphate + 7 H2O + 9 NADP(+) + 4 S-adenosyl-L-homocysteine => ATP + 12 H(+) + L-leucine + 8 malonyl-CoA + 9 NADPH + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48012", "l": "4-methyl-5-nitrocatechol + NADPH + O2 = 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39814", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43593", "l": "all-trans-zeaxanthin + O2 => (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73729", "l": "Formation of SL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36201", "l": "1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15557", "l": "ATP + H2O + Ni(2+)(out) = ADP + H(+) + Ni(2+)(in) + phosphate", "d": []}, {"i": "EC:7.2.2.11", "l": "\"ABC-type Ni(2+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64133", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021068", "l": "PalmS-ESRs bind CAVs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74069", "l": "ADP + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213208", "l": "Type X collagen associates with collagen type II fibrils (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60857", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.218", "l": "\"5-methylphenazine-1-carboxylate 1-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74188", "l": "S-adenosyl-L-methionine + taxifolin => H(+) + S-adenosyl-L-homocysteine + taxifolin 3'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50167", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050243", "l": "pyruvate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: CoA + NADP+ + pyruvate = acetyl-CoA + CO2 + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24102", "l": "diisopropyl phosphate + fluoride + 2 H(+) => diisopropyl fluorophosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853793", "l": "p-5Y-RET complexes bind GRB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-167429", "l": "The receptor:G-protein complex  binds GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20484", "l": "3'-phosphoadenylyl sulfate + coelenterazine h <=> adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22141", "l": "a nucleoside 5'-phosphate + H2O => a nucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23579", "l": "(R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] <=> berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32159", "l": "AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA", "d": []}, {"i": "EC:1.17.99.6", "l": "\"epoxyqueuosine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730862", "l": "Autophosphorylation of LYN kinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24464", "l": "2-dehydro-3-deoxy-6-phospho-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64893", "l": "holo-[ACP] + tetradecanoyl-AMP => AMP + H(+) + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24115", "l": "2 glutathione + O2 <=> glutathione disulfide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112434", "l": "Formation of DSIF complex  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592240", "l": "Formation of NRF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50941", "l": "L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) => cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31454", "l": "2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> a cardiolipin + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44056", "l": "2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA = 2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51085", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008489", "l": "UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-galactose + a glucosylceramide = a lactosylceramide + uridine-5'-diphosphate. The glucosylceramide has sphinganine as the long chain base."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40081", "l": "22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => docosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55723", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424485", "l": "Release of p-PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56507", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61634", "l": "5-aminopentanoate + 2 H(+) + NADH => 5-aminopentanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050622", "l": "glycine dehydrogenase (cyanide-forming) activity", "d": ["Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30831", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74298", "l": "n H(+)(out) + serotonin(in) <=> n H(+)(in) + serotonin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9015111", "l": "Factor Xa inhibitors binds Xa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34001", "l": "5alpha-cholesta-7,24-dien-3beta-ol => zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692228", "l": "DMRT1 binds the SOX9 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71649", "l": "a medium-chain (2E)-enoyl-CoA + H2O => a medium-chain (3S)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47042", "l": "5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein] => 5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65129", "l": "1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75009", "l": "H(+)(in) + VO(2+)(in) => H(+)(out) + VO(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5226999", "l": "ADD1:ADD3 binds DMTN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16848", "l": "acetyl-CoA + H2O + oxaloacetate <=> citrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54032", "l": "(6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose = (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70596", "l": "GOT2 dimer deaminates L-Asp (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57589", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043424", "l": "protein histidine kinase binding", "d": ["Binding to a protein histidine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2429643", "l": "NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11289", "l": "dihydromacarpine + H(+) + O2 => H2O2 + macarpine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692755", "l": "CDK1 phosphorylates MAPK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59373", "l": "1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51354", "l": "(9Z)-octadecenoate + L-serine => H2O + N-(9Z-octadecenoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913451", "l": "IL3RB is phosphorylated on Ser-585 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49620", "l": "D-erythritol 1-phosphate + NADP(+) = D-erythrulose 1-phosphate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.402", "l": "\"D-erythritol 1-phosphate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.113", "l": "\"pestivirus NS3 polyprotein peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19128", "l": "glyoxylate + L-serine <=> 3-hydroxypyruvate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802930", "l": "Dimerization of BRAF V600E splice variants contributes to BRAF inhibitor resistance (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042497", "l": "triacyl lipopeptide binding", "d": ["Binding to a lipopeptide containing a nonprotein moiety consisting of three acyl groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71088", "l": "17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) => 17beta-estradiol 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050048", "l": "L-leucine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862280", "l": "FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797554", "l": "ABP1 binds SHANK proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6805061", "l": "CK2 binds FACT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50586", "l": "15-oxoprostaglandin E1 + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047102", "l": "aminomuconate-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237119", "l": "Acireductone is oxidized to MOB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033442", "l": "AAC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AAC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45993", "l": "(3R)-3-hydroxydecanoyl-CoA => (2E)-decenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36600", "l": "hydrogen sulfide + NAD(+) => NADH + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61843", "l": "brassicasterol + UDP-alpha-D-glucose <=> brassicasterol 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928631", "l": "GIT1 binds bPIX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49634", "l": "(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+) => (2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26462", "l": "6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine = 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34835", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine = a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56019", "l": "H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66803", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141367", "l": "Myristoylation of tBID by NMT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47711", "l": "ADP + alpha-D-glucose 1-phosphate + H(+) <=> ADP-alpha-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862300", "l": "LYZ binds bacterial peptidoglycan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203979", "l": "Coat Assembly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60718", "l": "(1R,3R)-chrysanthemate + 2 H(+) + NADPH => (1R,3R)-chrysanthemal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57514", "l": "(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) => chlorobenzene + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33615", "l": "ATP + CoA + octadecanoate = AMP + diphosphate + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47096", "l": "(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate", "d": []}, {"i": "EC:2.5.1.86", "l": "\"trans,polycis-decaprenyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.54", "l": "\"gamma-renin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72482", "l": "citrate(out) + trans-aconitate(in) <=> citrate(in) + trans-aconitate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70315", "l": "beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45447", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164617", "l": "Elongation of Extended Telomeric Chromosome End (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2752115", "l": "SPP1 (osteopontin) binds CD44 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68378", "l": "2-oxosuccinamate + glycine => glyoxylate + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013109", "l": "RHOC GEFs activate RHOC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25465", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + longifolene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53638", "l": "1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71422", "l": "3,3',5-triiodo-L-thyronine(out) + L-tyrosine(in) <=> 3,3',5-triiodo-L-thyronine(in) + L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50260", "l": "11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26079", "l": "formaldehyde + H2O + NAD(+) + sulfite => methanesulfonate + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877620", "l": "ECE2 cleaves EDN1(53-90) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202692", "l": "PIP3 binds to RhoA and activates it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190263", "l": "FGFR3b binds to FGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67489", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65732", "l": "2-oxoglutarate + heptyl sulfate + O2 = CO2 + H(+) + heptanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48208", "l": "H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65852", "l": "a 3-oxo-Delta(1)-steroid + H2O = a 1-hydroxy-3-oxo steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050350", "l": "trihydroxystilbene synthase activity", "d": ["Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11716", "l": "a monoamide of a dicarboxylate + H2O = a dicarboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50491", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77068", "l": "Activation of GT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49907", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 <=> (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14870", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O => acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14563", "l": "CoA + H(+) + piperine => (E,E)-piperoyl-CoA + piperidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804402", "l": "TP53 binds POU4F1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.27", "l": "\"thermolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803801", "l": "TP53 in complex with ZNF385A binds the CDKN1A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41595", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH <=> 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67193", "l": "ATP + H2O + N-11-cis-retinylidenephosphatidylethanolamine(out) => ADP + H(+) + N-11-cis-retinylidenephosphatidylethanolamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46053", "l": "a 3'-end uridylyl-uridine-RNA => a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31999", "l": "(2E,6E)-farnesyl diphosphate = bicyclogermacrene + diphosphate", "d": []}, {"i": "EC:4.2.3.100", "l": "\"bicyclogermacrene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226014", "l": "Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12795", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP => 1D-myo-inositol hexakisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382056", "l": "Crk binds to the active PDGF receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.261", "l": "\"sn-glycerol-1-phosphate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392064", "l": "G alpha (z) inhibits adenylate cyclase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617326", "l": "CALM1:4xCa2+ binds GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors and displaces ACTN2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54921", "l": "13-cis-retinol + NADP(+) => 13-cis-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "43.580929300081294", "identifiers": [{"i": "GO:0060089", "l": "molecular transducer activity", "d": ["A compound molecular function in which an effector function is controlled by one or more regulatory components."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13028", "l": "3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] <=> 3-methyl-(2E)-glutaconyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12121", "l": "alpha-D-glucose 1-phosphate + ATP + H(+) => ADP-alpha-D-glucose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103096", "l": "CYP79F1 dihomomethionine monooxygenase activity", "d": ["Catalysis of the reaction: dihomomethionine + 2 O2 + 2 NADPH + 2 H+ <=> 5-methylthiopentanaldoxime + 3 H2O + carbon dioxide + 2 NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44381", "l": "a 3-demethylubiquinol + S-adenosyl-L-methionine => a ubiquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46318", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+) => GDP-N,N'-diacetylbacillosamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41428", "l": "L-tyrosine + S-adenosyl-L-methionine = 3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.304", "l": "\"L-tyrosine C(3)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49053", "l": "asperlicin C + H(+) + NADH + O2 => asperlicin E + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296043", "l": "Activation of HCN channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54534", "l": "2-oxoglutarate + L-cysteinylglycine => H2O + N-(4-oxoglutaryl)-L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876868", "l": "ECE1 cleaves EDN1(53-90) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25914", "l": "5-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-5-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61262", "l": "2-oxoglutaramate + H2O2 + NH4(+) => H2O + L-glutamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48448", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102013", "l": "ATPase-coupled L-glutamate tranmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-glutamate(out) -> ADP + phosphate + L-glutamate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67051", "l": "AH2 + chermesin D + O2 <=> A + asnovolin I + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060182", "l": "apelin receptor activity", "d": ["Combining with the peptide apelin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50305", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70397", "l": "CoA + H(+) + N-docosanoyl-3-ketodihydrosphingosine => 3-oxosphinganine + docosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23622", "l": "AMP + deoxyamidinoproclavaminate + diphosphate + H(+) => ATP + N(2)-(2-carboxyethyl)-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373705", "l": "Caspase cleavage of DCC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050574", "l": "2-(R)-hydroxypropyl-CoM dehydrogenase activity", "d": ["Catalysis of the reaction: 2-(R)-hydroxypropyl-coenzyme M + NAD+ = 2-oxopropyl-coenzyme M + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52866", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61319", "l": "germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24109", "l": "H2O + N-methyl-2-oxoglutaramate => 2-oxoglutarate + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265456", "l": "NPC1L1 binds ezetimibe (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24685", "l": "5,10-methylenetetrahydromethanopterin + NADP(+) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112333", "l": "SRC autophosphorylation is positively regulated by InlA-bound CDH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322434", "l": "XIAP dissociates from ub-TLE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22123", "l": "CoA + GTP + succinate <=> GDP + phosphate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018756", "l": "RHOH binds GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37725", "l": "1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236938", "l": "Partial proteolysis of antigen in phagolysosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50557", "l": "prostaglandin D2 => H2O + prostaglandin J2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000704", "l": "pyrimidine dimer DNA N-glycosylase activity", "d": ["Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061750", "l": "acid sphingomyelin phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+ in an acidic environment."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40642", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021357", "l": "PRKCI phosphorylates ELF3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35677", "l": "3-oxohexadecasphinganine + CO2 + CoA => H(+) + L-serine + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51936", "l": "2-(glutathione-S-yl)-hydroquinone + glutathione = glutathione disulfide + hydroquinone", "d": []}, {"i": "EC:1.8.5.7", "l": "\"glutathionyl-hydroquinone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21577", "l": "carnitine + H(+) => 2-methylcholine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69768", "l": "(E)-non-2-enal + H2O + NAD(+) => (E)-non-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55170", "l": "[TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate => [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37735", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33887", "l": "(-)-secoisolariciresinol + 2 NAD(+) = (-)-matairesinol + 2 H(+) + 2 NADH", "d": []}, {"i": "EC:1.1.1.331", "l": "\"secoisolariciresinol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22470", "l": "2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate => GTP + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38785", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53882", "l": "ADP + alpha,alpha-trehalose 6-phosphate + H(+) => ADP-alpha-D-glucose + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20039", "l": "aldehydo-D-glucose 6-phosphate + H(+) + NADPH => D-sorbitol 6-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30279", "l": "2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] = 3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.12.1.4", "l": "\"hydrogenase (NAD(+), ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35467", "l": "(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)", "d": []}, {"i": "EC:2.1.1.269", "l": "\"dimethylsulfoniopropionate demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043744", "l": "N2-acetyl-L-aminoadipate kinase activity", "d": ["Catalysis of the reaction: ATP + N-acetyl-L-2-aminoadipate = ADP + N-acetyl-L-2-aminoadipate 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015121", "l": "phosphoenolpyruvate:phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphoenolpyruvate(out) + phosphate(in) = phosphoenolpyruvate(in) + phosphate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179413", "l": "Activated PKC-alpha  activate MMP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033485", "l": "Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35940", "l": "brevianamide F + dimethylallyl diphosphate => diphosphate + tryprostatin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47141", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70621", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51495", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57223", "l": "GTP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19335", "l": "CO2 + formyl-CoA => H(+) + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23768", "l": "a fatty acyl-CoA + sphing-4-enine = an N-acylsphing-4-enine + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.24", "l": "\"sphingosine N-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30742", "l": "1D-myo-inositol 3-phosphate + H2O <=> myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43108", "l": "2 Fe(III)-[cytochrome c] + H2O + N2 = 2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide", "d": []}, {"i": "EC:1.7.2.4", "l": "\"nitrous-oxide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72758", "l": "3 ATP <=> 3',3',3'-c-tri-AMP + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018694", "l": "p-cymene methyl hydroxylase activity", "d": ["Catalysis of the reaction: p-cymene + NADH + O2 = NAD+ + OH- + p-cumic alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26477", "l": "beta-D-galactosyl-(1->4)-L-rhamnose + phosphate <=> alpha-D-galactose 1-phosphate + L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23723", "l": "ATP + hydrogencarbonate + propanoyl-CoA <=> (S)-methylmalonyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64194", "l": "(9Z)-octadecenoate + L-lysine => H2O + N-(9Z-octadecenoyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005457", "l": "GDP-fucose transmembrane transporter activity", "d": ["Enables the transfer of a GDP-fucose from one side of a membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031747", "l": "type 2 cysteinyl leukotriene receptor binding", "d": ["Binding to a type 2 cysteinyl leukotriene receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062054", "l": "fluoride channel activity", "d": ["Enables the facilitated diffusion of fluoride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28725", "l": "(S)-allantoin(out) + H(+)(out) => (S)-allantoin(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41629", "l": "geranylgeranyl diphosphate + H2O => cyclooctat-9-en-7-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54424", "l": "L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65707", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-3,6-dideoxy-alpha-D-mannose <=> alpha-D-Tyv-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48760", "l": "L-threitol + NAD(+) = H(+) + L-erythrulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014454", "l": "RHOG translocates to the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37665", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428917", "l": "G13 activation by TP receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605063", "l": "Expression of FASN regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849463", "l": "PTK6 phosphorylates SFPQ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13728", "l": "acetyl-CoA + alpha-D-glucosamine 1-phosphate <=> CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48321", "l": "ganglioside GA1 + GDP-beta-L-fucose => ganglioside Fuc-GA1 + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9737780", "l": "MTTP binds lomitapide (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72587", "l": "(E)-sinapate + ATP + CoA = (E)-sinapoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876789", "l": "CARNMT1 methylates CARN to Anserine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74346", "l": "O-hexanoyl-(R)-carnitine(in) <=> O-hexanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68343", "l": "(R)-4'-phospho-S-sulfopantetheine + H2O <=> (R)-S-sulfopantetheine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655170", "l": "RCHY1 monoubiquitinates POLH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57339", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose <=> 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46470", "l": "ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate => an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693929", "l": "RIPK1 variant is not cleaved by CASP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008743", "l": "L-threonine 3-dehydrogenase activity", "d": ["Catalysis of the reaction: L-threonine + NAD+ = L-2-amino-3-oxobutanoate + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670431", "l": "Phosphorylated KIT mutants bind PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209255", "l": "UPD ligand binds to the HOP:DOME:DOME:HOP complex and activates HOP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9640195", "l": "RRAGA,B hydrolyzes GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696457", "l": "BDH2 dehydrogenates 3HBA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807008", "l": "PTPRJ dephosphorylates MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20705", "l": "a D-alpha-amino acid + acetyl-CoA => an N-acetyl-D-amino acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50768", "l": "4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine = anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12340", "l": "L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218805", "l": "PKC autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29334", "l": "fumarate(in) + 2 H(+)(in) <=> fumarate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692539", "l": "HRH1 binds HRH1 inverse agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809663", "l": "Formation of hair keratin fibres (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54774", "l": "1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate => ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73911", "l": "ATP + psilocin = ADP + H(+) + psilocybin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33986", "l": "(+)-copalyl diphosphate <=> diphosphate + miltiradiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985201", "l": "ABCE1 binds RNASEL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29175", "l": "2 O2 + ubiquinol-8 = 2 H(+) + 2 superoxide + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56241", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013021", "l": "GDIs block activation of RHOB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55100", "l": "3-oxopentanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxypentanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047447", "l": "erythro-3-hydroxyaspartate ammonia-lyase activity", "d": ["Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29117", "l": "menaquinol-8 + NADP(+) => H(+) + menaquinone-8 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60132", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 = a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051990", "l": "(R)-2-hydroxyglutarate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66412", "l": "ATP + glutathione(in) + H2O + taurochenodeoxycholate(in) = ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75273", "l": "5-methoxytryptamine + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10275", "l": "a 1,2-diacyl-sn-glycerol + ATP <=> a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42392", "l": "D-galactose + NAD(+) = D-galactono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56725", "l": "AH2 + all-trans-beta-carotene + O2 => 4-hydroxy-all-trans-beta-carotene + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.58", "l": "\"N-acetylgalactosaminoglycan deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-350598", "l": "Arginine<=>Agmatine+CO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042933", "l": "chrysobactin transmembrane transporter activity", "d": ["Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209921", "l": "Monoiodinated tyrosine can be deiodinated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13049", "l": "D-glucuronate = D-fructuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63991", "l": "2-thiocytidine + ATP <=> 2-thiocytidine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24787", "l": "3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+) => 3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43905", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol => all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851018", "l": "BTN2A1 binds DC-SIGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021946", "l": "MECP2 binds GPRIN1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63206", "l": "H(+) + holo-[ACP] + octadecanoate => H2O + octadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937118", "l": "RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17174", "l": "glutathionylspermidine + H2O => glutathione + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635868", "l": "ub-GLI is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32916", "l": "sn-glycero-3-phospho-1D-myo-inositol(out) => sn-glycero-3-phospho-1D-myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15322", "l": "(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57668", "l": "alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51850", "l": "8-methylmenaquinol-6 + fumarate => 8-methylmenaquinone-6 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5221061", "l": "TDG excises 5-carboxylcytosine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218824", "l": "p-6Y-VEGFR2 binds FYN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033560", "l": "folate reductase activity", "d": ["Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9770141", "l": "Formation of the Spliceosomal C* complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71036", "l": "L-phenylalanine(out) + L-serine(in) => L-phenylalanine(in) + L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50951", "l": "a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O <=> a 2'-deoxyuridine in single-stranded DNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814374", "l": "Kazrin binds periplakin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462005", "l": "pro-defensin alpha 5 is secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "52.482924414077146", "identifiers": [{"i": "GO:0140096", "l": "catalytic activity, acting on a protein", "d": ["Catalytic activity that acts to modify a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26300", "l": "1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH <=> 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852362", "l": "GTSE1 binds CDKN1A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390059", "l": "HPO dimer binds to RASSF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68615", "l": "Formation of ORC(1-6) complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158313", "l": "factor XII -> factor XIIa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68291", "l": "heptanoyl-CoA + L-seryl-[protein] <=> CoA + O-heptanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55389", "l": "(3R)-3-hydroxy-2,3-dihydrotabersonine + A => (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32089", "l": "[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate => [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426209", "l": "DAG activation of TRPC channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72475", "l": "cis-aconitate(in) + citrate(out) = cis-aconitate(out) + citrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40902", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23679", "l": "ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382096", "l": "Formation of NR-NCOR Corepressor Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18256", "l": "(S)-malate + NADP(+) <=> CO2 + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052833", "l": "inositol monophosphate 4-phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29595", "l": "CoA + NADP(+) + sulfoacetaldehyde = H(+) + NADPH + sulfoacetyl-CoA", "d": []}, {"i": "EC:1.2.1.81", "l": "\"sulfoacetaldehyde dehydrogenase (acylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57532", "l": "a 5'-end ribonucleotide-RNA + ATP + H(+) = a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022141", "l": "Prolysyl oxidase activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38777", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15156", "l": "4-hydroxybenzoate + UDP-alpha-D-glucose <=> 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004063", "l": "aryldialkylphosphatase activity", "d": ["Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20425", "l": "2-oxoglutarate + ATP + hydrogencarbonate = (S)-oxalosuccinate + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.4.1.7", "l": "\"2-oxoglutarate carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33088", "l": "cyclic dehypoxanthinylfutalosinate => 1,4-dihydroxy-6-naphthoate + chemical entity", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975118", "l": "TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67062", "l": "asnovolin K + S-adenosyl-L-homocysteine => asnovolin I + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55069", "l": "a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] => a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14078", "l": "3-oxopropanoate + L-alanine => beta-alanine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16326", "l": "1-phospho-alpha-D-glucuronate + H(+) + UTP => diphosphate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033951", "l": "oligosaccharide reducing-end xylanase activity", "d": ["Catalysis of the hydrolysis of 1,4-beta-D-xylose residues from the reducing end of oligosaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29157", "l": "2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in) => 2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807106", "l": "PTEN undergoes monoubiquitination (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45083", "l": "3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine <=> ADP + dapdiamide E + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70104", "l": "H(+) + o-quinone methide + penilactone D => penilactone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791302", "l": "TP53 binds the AIFM2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48395", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49546", "l": "2-dehydro-3-deoxy-D-gluconate + NH4(+) => (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800798", "l": "The PIDDosome binds CASP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203977", "l": "SAR1 Activation And Membrane Binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102053", "l": "(-)-jasmonoyl-isoleucine synthetase activity", "d": ["Catalysis of the reaction: (-)-jasmonate + L-isoleucine + ATP(4-) <=> H+ + (-)-jasmonoyl-L-isoleucine + AMP(2-) + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015194", "l": "L-serine transmembrane transporter activity", "d": ["Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid."]}, {"i": "REACT:R-HSA-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54072", "l": "(2E)-geranyl diphosphate = beta-thujene + diphosphate", "d": []}, {"i": "EC:4.2.3.177", "l": "\"beta-thujene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42964", "l": "uridine(54/55) in tRNA = pseudouridine(54/55) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050633", "l": "acetyl-CoA C-myristoyltransferase activity", "d": ["Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047082", "l": "3,9-dihydroxypterocarpan 6a-monooxygenase activity", "d": ["Catalysis of the reaction: (6aR,11aR)-3,9-dihydroxypterocarpan + H+ + NADPH + O2 = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H2O + NADP+. (6aS,11aS)-3,6a,9-trihydroxypterocarpan is also known as (-)-glycinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954056", "l": "E2F6 binds TFDP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22225", "l": "3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA => 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27922", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605259", "l": "Active FLT3 binds FYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29669", "l": "H2O(out) => H2O(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61787", "l": "L-allulose <=> keto-L-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60934", "l": "17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56233", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O => [(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434989", "l": "SEMA7A binds to PLXNC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45141", "l": "2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O => CO2 + L-glutamyl-[protein] + O2 + phylloquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38798", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51086", "l": "16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12610", "l": "mercaptopurine + S-adenosyl-L-methionine => 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0009931", "l": "calcium-dependent protein serine/threonine kinase activity", "d": ["Calcium-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34608", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine => a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50556", "l": "prostaglandin D2 = H2O + prostaglandin J2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68719", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + germacrene D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42481", "l": "2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27875", "l": "isochorismate => pyruvate + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24844", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + 2 H2O = 2 isomaltose", "d": []}, {"i": "EC:3.2.1.204", "l": "\"1,3-alpha-isomaltosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65540", "l": "ganglioside GM3 + H2O = an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0004953", "l": "icosanoid receptor activity", "d": ["Combining with an icosanoid to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050548", "l": "trans-feruloyl-CoA hydratase activity", "d": ["Catalysis of the reaction: trans-feruloyl-CoA + H2O = 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67233", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA + NAD(+) => (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23017", "l": "(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) => (2R,3R)-dihydrokaempferol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667619", "l": "AVPR1A,B,2 bind atosiban (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72108", "l": "Na(+)(out) + O-acyl-(R)-carnitine(out) => Na(+)(in) + O-acyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805740", "l": "SETD8 methylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615536", "l": "MECP2 and SOX2 bind MIR137 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73524", "l": "TTP(out) + UTP(in) => TTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54107", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54815", "l": "(+)-7-isojasmonate + ATP + L-isoleucine <=> AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33595", "l": "(4R)-hydroxysphinganine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674531", "l": "AAMP binds EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68361", "l": "L-xylono-1,4-lactone + O2 => dehydro-L-arabinono-1,4-lactone + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983427", "l": "Expression of peptide bound class I MHC on cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57731", "l": "H(+) + trans-aconitate <=> CO2 + itaconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362522", "l": "ALDHs oxidise atRAL to atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23841", "l": "3-(2,3-dihydroxyphenyl)propanoate + O2 => (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47299", "l": "dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71207", "l": "iodide(out) + 2 Na(+)(out) = iodide(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49556", "l": "H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] = H(+) + L-cysteinyl-[protein] + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43600", "l": "3-oxoeicosanoyl-[ACP] + H(+) + NADPH = 3R-hydroxyeicosanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22017", "l": "[glutaredoxin]-dithiol + arsenate + glutathione + H(+) => arsenite + glutathionyl-S-S-[glutaredoxin] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159771", "l": "Furin cleaves pro-protein C to protein C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33490", "l": "(4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA <=> CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004483", "l": "mRNA (nucleoside-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24602", "l": "H2O2 + sulfate => H2O + O2 + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173705", "l": "C5b binds C6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042329", "l": "structural constituent of collagen and cuticulin-based cuticle", "d": ["The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle. An example of this process is found in Caenorhabditis elegans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14934", "l": "H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.958453806446542", "identifiers": [{"i": "GO:0016879", "l": "ligase activity, forming carbon-nitrogen bonds", "d": ["Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}, {"i": "EC:6.3.-.-", "l": "\"Forming carbon-nitrogen bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110219", "l": "Cleavage of thymine by TDG glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31962", "l": "9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35569", "l": "(9Z,12Z)-octadecadienoate + ethanolamine => H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5631885", "l": "PRDX1 overoxidizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857328", "l": "RPS6KA1/2/3 phosphorylates CEBPB on S321 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802999", "l": "DCD is processed into DCD(63-110) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14349", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.37", "l": "\"fucosylgalactoside 3-alpha-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53936", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 = 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675198", "l": "Activated MAPKs phosphorylate BRAF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668415", "l": "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36641", "l": "3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine => 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32018", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-delta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15018", "l": "a phosphate monoester + H2O => an alcohol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.134", "l": "\"galactolipid O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72262", "l": "L-dopa + S-adenosyl-L-methionine <=> 3-O-methyl-L-dopa + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036467", "l": "5-hydroxy-L-tryptophan decarboxylase activity", "d": ["Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin."]}, {"i": "RHEA:18533", "l": "5-hydroxy-L-tryptophan + H(+) = CO2 + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0046961", "l": "proton-transporting ATPase activity, rotational mechanism", "d": ["Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446322", "l": "PARVA associates with Paxillin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404135", "l": "RBP4 binds atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.21", "l": "\"membrane-oligosaccharide glycerophosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68097", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O => a 3'-end ribonucleotide-RNA + a 5'-end (5'-phospho)-ribonucleoside-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11284", "l": "hydroxymalonate + NAD(+) = H(+) + NADH + oxomalonate", "d": []}, {"i": "EC:1.1.1.167", "l": "\"hydroxymalonate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.205", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5444511", "l": "Formation of MSH2:MSH3 Complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62014", "l": "5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419334", "l": "Melatonin receptors can bind melatonin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798372", "l": "ATM phosphorylates DYRK2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40185", "l": "(2E)-tetradecenoyl-CoA + H2O2 => O2 + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46759", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730886", "l": "Phosphorylation of SHC by SYK kinase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69479", "l": "acetyl-CoA + L-lysine <=> CoA + H(+) + N(6)-acetyl-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27691", "l": "ATP + dGDP => ADP + dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327733", "l": "FN1 binds Collagen types I-V, VII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700120", "l": "PTN and MDK bind to PTPRZ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685604", "l": "SLAMF6 binds SLAMF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013143", "l": "RAC1 GEFs activate RAC1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130619", "l": "TGN-lysosomal vesicle coat assembly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53241", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70800", "l": "L-lysine(in) + L-ornithine(out) => L-lysine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73596", "l": "dCMP + H2O => dUMP + NH4+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354073", "l": "Autophosphorylation of PTK2 at Y397 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58787", "l": "2-oxoglutarate + a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 <=> a 5'-end triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710323", "l": "TP53 or TP63 binds the GSDME gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69005", "l": "Cdc6 protein is phosphorylated by CDK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75950", "l": "L-arginine + taurine <=> L-ornithine + taurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56065", "l": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose => 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0140807", "l": "NAD+-protein-glutamate ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-glutamyl-[protein] + NAD+ = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74730", "l": "Insulin degradation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44082", "l": "AMP + diphosphate + undecanoyl-CoA => ATP + CoA + undecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60292", "l": "L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.356", "l": "\"[histone H3]-lysine(27) N-trimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41379", "l": "1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57595", "l": "(S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0005516", "l": "calmodulin binding", "d": ["Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9681375", "l": "KIT binds ripretinib (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62102", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421517", "l": "Transport of delta-aminolevulinate from the mitochondrial matrix to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73726", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate <=> (2R,3S,11S)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928604", "l": "SFKs phosphorylate VAV2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31267", "l": "6-hydroxyhexanoate + NADP(+) = 6-oxohexanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65529", "l": "hexan-1-ol + octanoyl-CoA => CoA + hexyl octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655848", "l": "Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868071", "l": "Clathrin recruits PIK3C2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66169", "l": "[protein]-with a C-terminal TM segment(out) + ATP + H2O => [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879942", "l": "The receptor is activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220957", "l": "NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3857336", "l": "CEBPB homodimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60070", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+) => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75549", "l": "(2S)-2,6-bis[(3R)-3-isocyanobutanamido]hexan-1-ol + AMP + diphosphate + 2 holo-[ACP] + 2 NADP(+) => 2 (3R)-3-isocyanylbutanoyl-[ACP] + ATP + L-lysine + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60419", "l": "diglucosyl-enterobactin + H2O <=> H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63678", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH => CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25705", "l": "N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76042", "l": "(S)-cis-N-methyltetrahydrothalifendine + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-hydroxy-8-methoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.0(4,9).0(16,20)]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31742", "l": "a 4'-hydroxyisoflavone + S-adenosyl-L-methionine <=> a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60628", "l": "AH2 + gluconapin + O2 = A + H2O + progoitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71464", "l": "H2O + substance P => Gly-L-Leu-L-Met-NH2 + substance P(1-8)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33869", "l": "glycine + N-carbamoyl-2-oxoglycine => (S)-2-ureidoglycine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008929", "l": "methylglyoxal synthase activity", "d": ["Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70992", "l": "H(+)(in) + L-mannopyranose(in) => H(+)(out) + L-mannopyranose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034236", "l": "protein kinase A catalytic subunit binding", "d": ["Binding to one or both of the catalytic subunits of protein kinase A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.55", "l": "\"lytic starch monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753634", "l": "GGT dimers hydrolyse APAP-SG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11503", "l": "3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O <=> 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296309", "l": "HCAR3 binds HCAR3 ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199839", "l": "AKT can phosphorylate RSK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17601", "l": "ATP + D-ribulose = ADP + D-ribulose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043997", "l": "histone H4K12 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211219", "l": "Translocation of caspase-3 to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69583", "l": "dGMP + inosine <=> 2'-deoxyguanosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17149", "l": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.1", "l": "\"unspecific monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67109", "l": "L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11301", "l": "1D-5-O-methyl-myo-inositol + NAD(+) => 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.843050782660015", "identifiers": [{"i": "GO:0050308", "l": "sugar-phosphatase activity", "d": ["Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.227", "l": "\"undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27423", "l": "(3E,6E)-alpha-farnesene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30722", "l": "acetyl-CoA + propanoyl-CoA <=> 2-methyl-3-oxobutanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653936", "l": "Formation of Ragulator complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174121", "l": "Association of Securin with Cdc20:APC/C complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730841", "l": "Phosphorylation and activation of VAV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534365", "l": "Slo3 Potassium Transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73634", "l": "CTP(out) + dGTP(in) <=> CTP(in) + dGTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33610", "l": "(9Z)-octadecenoate + ATP + CoA <=> (9Z)-octadecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.32", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18540", "l": "H2O + NAD(+) + salicylaldehyde <=> 2 H(+) + NADH + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33375", "l": "a 1-acylglycerone 3-phosphate + H(+) + NADPH = a 1-acyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709406", "l": "CO binds to Cytochrome c oxidase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48373", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46368", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10635", "l": "D-mannonate + NAD(+) <=> D-mannuronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949145", "l": "VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24994", "l": "2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase] => L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679239", "l": "ULK complex translocates to the ER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44158", "l": "myo-inositol + phosphate => 1D-myo-inositol 5-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046817", "l": "chemokine receptor antagonist activity", "d": ["Interacts with chemokine receptors to reduce the action of a chemokine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48005", "l": "1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 => 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56392", "l": "[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28944", "l": "glycine betaine(in) => glycine betaine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20475", "l": "(R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+) => (R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72724", "l": "UDP-alpha-D-xylose(in) + UMP(out) => UDP-alpha-D-xylose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24209", "l": "1,5-anhydro-D-mannitol + NADP(+) => 1,5-anhydro-D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39199", "l": "(3R)-hydroxytetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36706", "l": "(2S,5S)-5-carboxymethylproline + ATP <=> (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57031", "l": "FADH2 + N-methylnicotinate + O2 <=> (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205118", "l": "TRAF6 polyubiquitinates NRIF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16618", "l": "beta-D-glucosyl-(1->3)-D-glucose + phosphate => alpha-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211951", "l": "CYP1B1 4-hydroxylates EST17b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159771", "l": "Furin cleaves pro-protein C to protein C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55539", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose <=> a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.6", "l": "\"coagulation factor Xa\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15953", "l": "agmatine + ATP = ADP + 2 H(+) + N(4)-phosphoagmatine", "d": []}, {"i": "EC:2.7.3.10", "l": "\"agmatine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58432", "l": "(E)-4-oxonon-2-en-1-ol + NADP(+) = (E)-4-oxonon-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20845", "l": "ATP + hydrogencarbonate + pyruvate => ADP + H(+) + oxaloacetate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428531", "l": "Recruitment of PAK to NCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52312", "l": "NAD(+) + thromboxane B2 = 11-dehydro-thromboxane B2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44771", "l": "3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) <=> 2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58923", "l": "(3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol <=> (+)-medicarpin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45716", "l": "H2O + N,N,N-trimethylglycyl-CoA = CoA + glycine betaine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10281", "l": "1,7-dimethylxanthine + S-adenosyl-L-methionine => caffeine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64965", "l": "dUTP + 2 H2O => dUMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56426", "l": "(9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine => H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45054", "l": "CoA + O-(2E)-butenoyl-(R)-carnitine => (2E)-butenoyl-CoA + (R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49997", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62654", "l": "6 CO2 + 7 CoA + H2O + naphtopyrone YWA1 => acetyl-CoA + 6 H(+) + 6 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49555", "l": "H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] <=> H(+) + L-lysyl-[protein] + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75553", "l": "AMP + an isonitrile lipopeptide + diphosphate + 2 holo-[ACP] + 2 NADP(+) => 2 a (3R)-3-isocyanyl-fatty acyl-[ACP] + ATP + L-lysine + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389756", "l": "AKT interacts and phosphorylates Cot (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-354097", "l": "Activation of Talin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21662", "l": "benzoate + 2 H(+) + NADPH => benzaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34758", "l": "H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine <=> D-glucose + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74656", "l": "ITP + N-acetyl-D-glucosamine => H(+) + IDP + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11661", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O => acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605717", "l": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Bos taurus)", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102870", "l": "7-hydroxyflavone-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 7-hydroxyflavone <=> 7-O-beta-D-glucosyl-7-hydroxyflavone + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702607", "l": "pexidartinib-resistant FLT3 mutants don't bind pexidartinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59663", "l": "D-cellotetraose + O2 <=> D-cellotetraono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9761027", "l": "ZEB2 binds SP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41131", "l": "1-decanoyl-sn-glycero-3-phosphocholine + H2O = 1-decanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69845", "l": "a uridine in RNA + H(+) + NADH => a 5,6-dihydrouridine in RNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14735", "l": "ADP + Ag(+)(out) + H(+) + phosphate => Ag(+)(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.3", "l": "\"ribonuclease III\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9619376", "l": "CAMK1 binds calmodulin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16160", "l": "2 Fe(III)-[leghemoglobin] + NADPH <=> 2 Fe(II)-[leghemoglobin] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21870", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+) => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111962", "l": "PDE4A,C,D hydrolyse cAMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59980", "l": "8-oxo-dGTP + H2O = 8-oxo-dGDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31277", "l": "(S)-methylmalonate semialdehyde + H(+) + NADH => (S)-3-hydroxy-2-methylpropanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534365", "l": "Slo3 Potassium Transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110485", "l": "DTSC1 AND DTSC2 form a complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678327", "l": "MIOX oxidises Ins to GlcA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18114", "l": "a ribonucleoside 5'-diphosphate + ATP => a ribonucleoside 5'-triphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13388", "l": "3-oxododecanoate + H(+) <=> 2-undecanone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16343", "l": "(R)-5-diphosphomevalonate + ADP => (R)-5-phosphomevalonate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758529", "l": "SARS-CoV-2 N binds MASP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161732", "l": "TXB2 is converted to 11dh-TXB2 by TXDH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48193", "l": "(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373087", "l": "Receptor CCR6 binds CCL20 ligand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198314", "l": "DAG stimulates protein kinase C-delta (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76027", "l": "(S)-reticuline + 2-oxoglutarate + O2 = (S)-6-O-demethylreticuline + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914022", "l": "SHP2 can recruit GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26104", "l": "(2R)-homocitrate <=> cis-homoaconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729841", "l": "SARS-CoV-2 nsp8 binds to 7SL RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645598", "l": "RRAGC,D hydrolyzes GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2467811", "l": "Separation of sister chromatids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35750", "l": "(2E,6E)-farnesyl diphosphate <=> 7-epizingiberene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043878", "l": "glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.53", "l": "\"beta-N-acetylgalactosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39390", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA <=> (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28715", "l": "(R)-malate(in) + 2 H(+)(in) = (R)-malate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391935", "l": "DP1 receptor can bind PGD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35005", "l": "L-fucose(out) => L-fucose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090353", "l": "polygalacturonase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of polygalacturonase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16400", "l": "2 D-glucopyranose 1-phosphate <=> D-glucose + D-glucose 1,6-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66937", "l": "(E)-caffeoyl-CoA + 5-hydroxyanthranilate => avenanthramide C + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18016", "l": "H2O + N(5)-ethyl-L-glutamine <=> ethylamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0009039", "l": "urease activity", "d": ["Catalysis of the reaction: urea + H2O = CO2 + 2 NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69105", "l": "2-oxo-3-sulfanylpropanoate + L-kynurenine => H2O + kynurenate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0005356", "l": "glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697855", "l": "Superoxide and nitric oxide react to form peroxynitrite in mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1369052", "l": "ABCAs mediate lipid influx (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174171", "l": "Association of Cyclin A with the APC/C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687465", "l": "MRN complex binds RBBP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173636", "l": "Formation of classic pathway C5 convertase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47877", "l": "ganglioside GD1b + H2O => ganglioside GM1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140936", "l": "histone H2B deubiquitinase activity", "d": ["A histone deubiquitinase that cleaves ubiquitin from a histone H2B protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112392", "l": "Resumption of elongation after recovery from pausing (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400272", "l": "FBXL3 binds phosphorylated CRY proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60009", "l": "a tRNA precursor + 2 CTP => a tRNA with a 3' CC end + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622377", "l": "CEBPB mRNA is translated to yield CEBPB protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49342", "l": "2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3315455", "l": "Defective CBLIF does not bind Cbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52813", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11449", "l": "NAD(+) + pregnan-21-ol => H(+) + NADH + pregnan-21-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50982", "l": "prostaglandin E1(in) => prostaglandin E1(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28585", "l": "ATP + dUDP <=> ADP + dUTP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047996", "l": "hydroxyphytanate oxidase activity", "d": ["Catalysis of the reaction: (2S)-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22369", "l": "L-ribulose 5-phosphate => D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22908", "l": "3',5'-cyclic AMP + H(+) + H2O = 3',5'-cyclic IMP + NH4(+)", "d": []}, {"i": "EC:3.5.4.46", "l": "\"cAMP deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804266", "l": "CHEK2 phosphorylates TTC5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44459", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9689680", "l": "IFNG dimer binds IFNG inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16949", "l": "myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose", "d": []}, {"i": "EC:1.1.1.18", "l": "\"inositol 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210274", "l": "SIRP beta binds TYROBP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47983", "l": "dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9705926", "l": "AR binds AR agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15265", "l": "1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate", "d": []}, {"i": "EC:2.6.99.2", "l": "\"pyridoxine 5'-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134800", "l": "STING dimerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42517", "l": "H2O + L-gulono-1,4-lactone => H(+) + L-gulonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351894", "l": "Caspase mediated cleavage of BAP31 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604471", "l": "FLT4 gene expression is stimulated by NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114284", "l": "Release of Cytochrome c from mitochondria (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45066", "l": "ethanolamine + hexadecanoate => H2O + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65367", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O <=> a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265456", "l": "NPC1L1 binds ezetimibe (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68925", "l": "ATP + H(+) + hexanoate + NADPH => AMP + diphosphate + hexanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9007882", "l": "IL1F10 is cleaved (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.76", "l": "\"myeloblastin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72283", "l": "a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72671", "l": "6-hydroxyphenazine-1-carboxylate + 2 H(+) + NADH + O2 = 1,6-dihydroxyphenazine + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15375", "l": "H(+) + palmatine + S-adenosyl-L-homocysteine => columbamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373741", "l": "SDK2 homophillic interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10904", "l": "[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A = AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide", "d": []}, {"i": "EC:1.3.99.36", "l": "\"cypemycin cysteine dehydrogenase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51698", "l": "H(+) + S-adenosyl-L-homocysteine + xanthohumol => desmethylxanthohumol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52601", "l": "L-methionine + propanoyl-CoA => CoA + H(+) + N-propanoyl-L-methioninate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15780", "l": "1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O <=> 1-guanidino-1-deoxy-scyllo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59142", "l": "AMP + diphosphate + H(+) + staphyloferrin A => ATP + citrate + N(5)-[(S)-citryl]-D-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202168", "l": "Phosphorylation of ZAP-70 by Lck (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018826", "l": "RHOT2 hydrolyzes GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22288", "l": "an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose", "d": []}, {"i": "EC:3.2.1.123", "l": "\"endoglycosylceramidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029273", "l": "PI3K binds to p-6Y-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611851", "l": "ADRB2 bind ADR,NAd (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63913", "l": "6-azauridine + ATP => 6-azauridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46905", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75264", "l": "isovitexin + O2 => 3'-dehydroisovitexin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036221", "l": "UTP diphosphatase activity", "d": ["Catalysis of the reaction: UTP + H2O = UMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71879", "l": "2'-deoxyguanosine + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-2'-deoxyguanosine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62453", "l": "ATP + holo-[peptidyl-carrier protein] + L-glutamate => AMP + diphosphate + L-glutamyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052916", "l": "23S rRNA (guanine(1835)-N(2))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37637", "l": "1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336184", "l": "GPR37L binds prosaposin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632672", "l": "ADRBK1 phosphorylates SMO dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28866", "l": "H(+)(out) + lactose(in) <=> H(+)(in) + lactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74649", "l": "GDP + H(+) + N-acetyl-D-glucosamine 6-phosphate => GTP + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416690", "l": "SEMA4A binds to PLXND1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008160", "l": "protein tyrosine phosphatase activator activity", "d": ["Binds to and increases the activity of a phosphotyrosine phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189488", "l": "UROS transforms HMB to URO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445072", "l": "Interaction of PAK1 with Rac1-GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10278", "l": "1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66768", "l": "ATP + coproporphyrin I(in) + H2O = ADP + coproporphyrin I(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483186", "l": "PC is converted to PS by PTDSS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51414", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46334", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875661", "l": "GGA3 associates with activated MET receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18338", "l": "D-ribose 5-phosphate + uracil => H2O + psi-UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40018", "l": "(+)-copalyl diphosphate + H2O <=> 13-epi-manool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12739", "l": "[PrdC protein]-L-selenocysteine/L-cysteine + D-proline => 5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200406", "l": "CPT1A,B transfers PALM to CAR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9667965", "l": "ANKLE2 binds PP2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50677", "l": "H(+) + H2O + N-terminal L-asparaginyl-[protein] => N-terminal L-aspartyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48808", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64144", "l": "H2O + N-(9Z-octadecenoyl)-L-methionine = (9Z)-octadecenoate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5674385", "l": "p-T,Y MAPKs dimerize (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57517", "l": "dolabradiene + O2 + reduced [NADPH--hemoprotein reductase] => 15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24637", "l": "H2 + NAD(+) => H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42209", "l": "a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2 => a (Z)-omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761836", "l": "p14ARF binds NFE2L2:CREBBP, EP300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750226", "l": "NLRC5 binds IKBKB and CHUK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627106", "l": "SMAC (DIABLO) forms dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72275", "l": "oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60028", "l": "(2E)-geranyl diphosphate + H2O = 4-terpineol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873918", "l": "Transphosphorylation of JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35712", "l": "acetate + succinyl-CoA => acetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10793", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730842", "l": "PI3K associates with phosphorylated GAB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015225", "l": "biotin transmembrane transporter activity", "d": ["Enables the transfer of biotin from one side of a membrane to the other. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions."]}, {"i": "RHEA:28458", "l": "biotin(in) = biotin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672173", "l": "Autophosphorylation of PDGFRA extracellular domain dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694527", "l": "Loss of SAR1B GTPase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14700", "l": "(2E,6E)-farnesol + NADP(+) <=> (2E,6E)-farnesal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043785", "l": "cinnamoyl-CoA:phenyllactate CoA-transferase activity", "d": ["Catalysis of the reaction: (R)-3-phenyllactate + [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonatooxy)oxolan-2-yl]methyl {[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-{[(2E)-3-phenylprop-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)propyl phosphonato]oxy}phosphonate = (R)-3-phenyllactoyl-CoA + trans-cinnamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46255", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004637", "l": "phosphoribosylamine-glycine ligase activity", "d": ["Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031299", "l": "taurine-pyruvate aminotransferase activity", "d": ["Catalysis of the reaction: pyruvate + taurine = L-alanine + sulfoacetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814153", "l": "ADO oxidises 2AET to HTAU (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50776", "l": "hexanal + NADP(+) = (E)-hex-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879674", "l": "CD97 binds CD55 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53850", "l": "7-oxo-taurodeoxycholate + H(+) + NADH => NAD(+) + taurocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52476", "l": "estrone + UDP-alpha-D-glucuronate = estrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388900", "l": "Neurotensin receptors can bind neurotensins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55232", "l": "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 Fe(III)-[cytochrome b561] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432556", "l": "Cytosolic PP2A dephosphorylates phosphorylated PER complexed with DCO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17025", "l": "NADP(+) + xylitol = H(+) + L-xylulose + NADPH", "d": []}, {"i": "EC:1.1.1.10", "l": "\"L-xylulose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23125", "l": "2 (2R)-3-phosphoglycerate + 2 H(+) => CO2 + D-ribulose 1,5-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9676268", "l": "Formation of the MLL4 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47548", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oate = 3-oxochola-4,6-dien-24-oate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.-", "l": "\"Aspartic endopeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28526", "l": "(R)-carnitine + crotonobetainyl-CoA = (R)-carnitinyl-CoA + crotonobetaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58034", "l": "8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75271", "l": "S-adenosyl-L-methionine + serotonin = 5-methoxytryptamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635102", "l": "GPR161 is internalized (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15631", "l": "an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin] => a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61387", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O <=> 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68080", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29887", "l": "ATP + H2O + L-lysine(out) = ADP + H(+) + L-lysine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68836", "l": "(2Z,6E)-farnesyl diphosphate = (6R,7S)-himachala-9,11-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132122", "l": "Activation of C1r within the C1complement complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52408", "l": "4-phospho-D-erythronate + NAD(+) = CO2 + dihydroxyacetone phosphate + NADH", "d": []}, {"i": "EC:1.1.1.409", "l": "\"4-phospho-D-erythronate 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70661", "l": "H(+)(out) + N,N-dimethylglycine(out) => H(+)(in) + N,N-dimethylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0030552", "l": "cAMP binding", "d": ["Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702997", "l": "linafinib-resistant FLT3 mutants don't bind linifanib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863973", "l": "Fusion of ERC and phagosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852552", "l": "MST1R autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50989", "l": "prostaglandin F2alpha(out) => prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0016493", "l": "C-C chemokine receptor activity", "d": ["Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10482", "l": "4-hydroxy-2-oxoglutarate + L-glutamate => 2-oxoglutarate + 4-hydroxy-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69472", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose = a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + H(+) + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.305", "l": "\"acyl-[acyl-carrier protein]--UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose N-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49136", "l": "H(+) + L-methionyl-[protein] + NADPH + O2 = H2O + L-methionyl-S-oxide-[protein] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51352", "l": "H2O + N-(9Z-octadecenoyl)-L-serine = (9Z)-octadecenoate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.113", "l": "\"mannosyl-oligosaccharide 1,2-alpha-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731149", "l": "Syndecan-4 binds ACTN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004616", "l": "phosphogluconate dehydrogenase (decarboxylating) activity", "d": ["Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928639", "l": "p-EFNB binds GRB4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5140741", "l": "WNT5A binds FZD and ROR receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72103", "l": "Formation of pre-mRNPs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41930", "l": "NADP(+) + octadecanoyl-[ACP] => (2E)-octadecenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050102", "l": "cellodextrin phosphorylase activity", "d": ["Catalysis of the reaction: 1,4-beta-D-glucosyl(n) + phosphate = 1,4-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33778", "l": "a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine <=> 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42280", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17431", "l": "4-oxocyclohexanecarboxylate + H(+) + NADH => NAD(+) + trans-4-hydroxycyclohexanecarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378952", "l": "Thyrotropin is a heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24101", "l": "diisopropyl fluorophosphate + H2O => diisopropyl phosphate + fluoride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140680", "l": "histone H3K36me/H3K36me2 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55338", "l": "a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14608", "l": "D-glucose 6-phosphate + GDP-alpha-D-glucose <=> alpha,alpha-trehalose 6-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016161", "l": "beta-amylase activity", "d": ["Catalysis of the reaction: (1,4-alpha-D-glucosyl)(n+1) + H2O = (1,4-alpha-D-glucosyl)(n-1) + alpha-maltose. This reaction is the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37451", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33554", "l": "an N-acylsphinganine + H2O <=> a fatty acid + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102526", "l": "8-demethylnovobiocic acid C8-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 8-desmethylnovobiocic acid <=> S-adenosyl-L-homocysteine + novobiocic acid + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134946", "l": "DDX41 ubiquitination by TRIM21 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64921", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H2O => a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56987", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45415", "l": "H2O + prostaglandin D2-1-glycerol ester <=> glycerol + H(+) + prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120053", "l": "ribitol beta-1,4-xylosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-xylose + D-ribitol 5-phosphate-R = UDP + beta1,4-xylosyl-D-ribitol 5-phosphate-R."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052598", "l": "histamine oxidase activity", "d": ["Catalysis of the reaction: histamine + H2O + O2 = imidazole-4-acetaldehyde + NH3 + hydrogen peroxide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34828", "l": "H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2 => H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28822", "l": "5-dehydro-D-gluconate(in) + H(+)(in) <=> 5-dehydro-D-gluconate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433415", "l": "Activation of RAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-178208", "l": "SMAD7 binds to SMURF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190519", "l": "Internalization of gap junction plaques (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30583", "l": "2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide = 2-demethylmenaquinone-8 + H2O + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23126", "l": "CO2 + D-ribulose 1,5-bisphosphate + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46080", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADH = NAD(+) + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20462", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine => an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66941", "l": "acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine => 12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018781", "l": "S-triazine hydrolase activity", "d": ["Catalysis of the reaction: 1-halo or 1-pseudohalo-S-triazine = 1-hydroxy-S-triazine."]}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0034353", "l": "mRNA 5'-diphosphatase activity", "d": ["Catalysis of the removal of a 5' terminal diphosphate from the 5'-triphosphate end of an mRNA, leaving a 5'-monophosphate end."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141341", "l": "SMOX-3 oxidises SPN to SPM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31544", "l": "all-trans-zeaxanthin + 2 UDP-alpha-D-glucose => 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.23.1.-", "l": "\"With NADH or NADPH as donor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9641111", "l": "Parkin transfers Ub to misfolded proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60940", "l": "(9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = (9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008843", "l": "endochitinase activity", "d": ["Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990448", "l": "exon-exon junction complex binding", "d": ["Binding to an exon-exon junction complex, a protein complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73541", "l": "dCTP(in) + UTP(out) => dCTP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57436", "l": "guaethol + O2 + reduced [NADH--hemoprotein reductase] = acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102602", "l": "cytochrome P450 dependent 16beta-hydroxy-beta-amyrin epoxidase activity", "d": ["Catalysis of the reaction: 16beta-hydroxy-beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P)."]}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0050780", "l": "dopamine receptor binding", "d": ["Binding to a dopamine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693783", "l": "NAALADases hydrolyse NAAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0032450", "l": "maltose alpha-glucosidase activity", "d": ["Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32632", "l": "erythromycin D + H(+) + NADPH + O2 => erythromycin C + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.5.2", "l": "\"caffeine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52265", "l": "3-(aminomethyl)indole + 2 S-adenosyl-L-methionine => gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20028", "l": "gibberellin A3 + UDP-alpha-D-glucose <=> gibberellin A3 O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047899", "l": "formate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: formate + NADP+ = CO2 + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684008", "l": "NBN binds KPNA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089702", "l": "undecaprenyl-phosphate glucose phosphotransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + ditrans,octacis-undecaprenyl phosphate = UMP + alpha-D-glucopyranosyl-diphospho-ditrans,octacis-undecaprenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66242", "l": "AMP + diphosphate + IC-asc-C9-CoA => ATP + CoA + IC-asc-C9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24845", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + 2 H2O => 2 isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851988", "l": "BTN2A2 binds T cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42407", "l": "H2O + lactose 6-phosphate <=> beta-D-glucose + D-galactose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389463", "l": "Proteinase-activated receptors can bind thrombin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16493", "l": "glycerol 1,2-cyclic phosphate + H2O = glycerol 1-phosphate + H(+)", "d": []}, {"i": "EC:3.1.4.42", "l": "\"glycerol-1,2-cyclic-phosphate 2-phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37971", "l": "H(+) + NADPH + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 H2O + NADP(+)", "d": []}, {"i": "EC:1.14.19.n4", "l": "\"stearoyl-CoA 9-desaturase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.1", "l": "\"ethanolaminephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33792", "l": "H2O + sucrose 6(F)-phosphate => beta-D-fructose + beta-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64411", "l": "2 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) <=> 2 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23501", "l": "H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) => 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13630", "l": "(1S,5R)-carveol + NADP(+) => (R)-carvone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17349", "l": "(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole = 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate", "d": []}, {"i": "EC:2.5.1.146", "l": "\"3-geranyl-3-[(Z)-2-isocyanoethenyl]indole synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60120", "l": "(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine = H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.363", "l": "\"pre-sodorifen synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53057", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73296", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine => 7,8-dihydroxy-4'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30568", "l": "5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate => 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70420", "l": "3,4-dihydroxyphenylacetyl-CoA + H2O => 3,4-dihydroxyphenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112436", "l": "Formation of Elongin complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64376", "l": "8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid = a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69090", "l": "butanoate + 2 H(+) + NADH => butanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46404", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.25", "l": "\"acyl-lipid omega-3 desaturase (cytochrome b5)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33762", "l": "a 3-oxo-fatty acyl-CoA + H(+) + NADPH <=> a 3-hydroxy-fatty acyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71315", "l": "chloride(out) + L-serine(out) + 2 Na(+)(out) = chloride(in) + L-serine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11888", "l": "an aldehyde + H2O + NADP(+) = a carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798372", "l": "ATM phosphorylates DYRK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35932", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070856", "l": "myosin VI light chain binding", "d": ["Binding to a light chain of a myosin VI complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18524", "l": "licodione + S-adenosyl-L-methionine <=> 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69156", "l": "spermine dialdehyde = acrolein + N-(4-aminobutyl)-3-aminopropanal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031819", "l": "P2Y10 nucleotide receptor binding", "d": ["Binding to a P2Y10 nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3159259", "l": "MMAA:MUT binds AdoCbl (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3204303", "l": "MRE11 binds cytosolic DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0019152", "l": "acetoin dehydrogenase activity", "d": ["Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58173", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => beta-pinacene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033476", "l": "Dimerization of FGFR3 point mutants with enhanced kinase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72603", "l": "(E)-sinapate + ATP + H(+) = (E)-sinapoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44188", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14383", "l": "4-guanidinobutanoate + 2 H(+) + NADH => 4-guanidinobutanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191784", "l": "snRNA Cap hypermethylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174157", "l": "Degradation of multiubiquitinated Cyclin B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35953", "l": "diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate => (7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140953", "l": "histone H3K27 monomethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl27-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl27-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75191", "l": "2-dehydro-3-deoxy-L-fuconate + NAD(+) = 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56467", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O <=> 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13481", "l": "ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)", "d": []}, {"i": "EC:6.1.1.10", "l": "\"methionine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30750", "l": "FAD + H(+) + hexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29495", "l": "(2E,6E)-farnesyl diphosphate + H2O = beta-eudesmol + diphosphate", "d": []}, {"i": "EC:4.2.3.68", "l": "\"beta-eudesmol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874082", "l": "MET phosphorylates PTK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047317", "l": "N6-acetyl-beta-lysine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + 3-amino-6-acetamidohexanoate = L-glutamate + 3-oxo-6-acetamidohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75239", "l": "acetyl-CoA + N-terminal L-methionyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10108", "l": "(7S)-salutaridinol + NADP(+) = H(+) + NADPH + salutaridine", "d": []}, {"i": "EC:1.1.1.248", "l": "\"salutaridine reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11931", "l": "hydroxylamine + NH4(+) <=> H(+) + H2O + hydrazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36101", "l": "methyl benzoate + S-adenosyl-L-homocysteine => benzoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10702", "l": "limonene-1,2-diol => H2O + limonene 1,2-epoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34652", "l": "3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine => 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30767", "l": "D-glucurono-3,6-lactone + H2O = D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62556", "l": "3,4-dihydroxyphenylacetate + H(+) = 4-methylcatechol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019781", "l": "NEDD8 activating enzyme activity", "d": ["Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade."]}, {"i": "EC:6.2.1.64", "l": "\"E1 NEDD8-activating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48218", "l": "(2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854209", "l": "TBC1D10A binds JFC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16046", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68709", "l": "(2E)-geranyl diphosphate + H2O => diphosphate + linalool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209891", "l": "Dopamine is oxidised to noradrenaline (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850786", "l": "SPINK6 binds KLK12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59320", "l": "D-cellobiono-1,5-lactone + H2O = 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237119", "l": "Acireductone is oxidized to MOB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051747", "l": "cytosine C-5 DNA demethylase activity", "d": ["Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34613", "l": "H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP => N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49862", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59862", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376134", "l": "NrCAM binds synapse-associated proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74740", "l": "Binding of SHC1 to insulin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47266", "l": "AMP + diphosphate + pristanoyl-CoA => 2,6,10,14-tetramethylpentadecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090483", "l": "phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity", "d": ["Catalysis of the reaction: phosphatidylglycerol + phosphatidylethanolamine = cardiolipin + ethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56527", "l": "A + dihydro-heme d1 <=> AH2 + heme d1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65140", "l": "AH2 + O2 + protoaustinoid A = A + berkeleyone A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54282", "l": "(3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52911", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + O2 <=> 3-dimethylallyl-4-hydroxymandelate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48043", "l": "globoside Gb4Cer + H2O <=> globoside Gb3Cer + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976742", "l": "NOTCH2 coactivator complex binds FCER2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18797", "l": "a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788622", "l": "p-Y-STATs dimerize (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40851", "l": "FAD + H(+) + pentadecanoyl-CoA = (2E)-pentadecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10171", "l": "15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] <=> biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46397", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an (11E)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.26", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990890", "l": "netrin receptor binding", "d": ["Binding to a netrin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38059", "l": "2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247843", "l": "secretion of WNT ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12672", "l": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] <=> L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11398", "l": "5-methyldeoxycytidine diphosphate + ADP => 5-methyldeoxycytidine 5'-phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102431", "l": "acyl-lipid omega-(9-4) desaturase activity", "d": ["Catalysis of the reaction: a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid) and add a fourth double bond (a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56045", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177501", "l": "Endocytosis (internalization) of clathrin-coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33848", "l": "H2O + N-tetracosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28143", "l": "H2O + streptothricin D => streptothricin D acid", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018494", "l": "carvone reductase activity", "d": ["Catalysis of the reaction: carvone + 2 H+ + 2 e- = dihydrocarvone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54036", "l": "[mycoredoxin]-L-cysteine + arseno-mycothiol + H(+) = [mycoredoxin]-S-mycothiol-L-cysteine + arsenite", "d": []}, {"i": "EC:1.20.4.3", "l": "\"mycoredoxin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56860", "l": "a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate = a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.277", "l": "\"2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75796", "l": "Na(+)(out) + nicotinate(out) => Na(+)(in) + nicotinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951727", "l": "cAMP binds PKA tetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36133", "l": "methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine => (indol-3-yl)acetate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35338", "l": "H(+) + isopentadecanoyl-CoA + malonyl-CoA <=> 3-oxoisoheptadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49550", "l": "H(+) + L-arginyl-[protein] + lactate => H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40216", "l": "FADH2 + O2 => FAD + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47296", "l": "dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54038", "l": "[mycoredoxin]-S-mycothiol-L-cysteine + arsenite => [mycoredoxin]-L-cysteine + arseno-mycothiol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74734", "l": "Re-integration of insulin receptor into plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027670", "l": "ESTG binding induces ESR depalmitoylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174446", "l": "Removal of remaining Flap from the C-strand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047777", "l": "(S)-citramalyl-CoA lyase activity", "d": ["Catalysis of the reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.98.-", "l": "\"With other, known acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9016526", "l": "RUNX2-P2 binds RUNX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.413456430472493", "identifiers": [{"i": "GO:0016774", "l": "phosphotransferase activity, carboxyl group as acceptor", "d": ["Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59330", "l": "D-xylonate + H(+) => D-xylono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38544", "l": "H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] => (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35226", "l": "2-oxo-dADP + H2O <=> 2-oxo-dAMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30981", "l": "AH2 + all-trans-3,4-didehydrolycopene => A + all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65023", "l": "L-ornithine + succinyl-CoA <=> CoA + H(+) + N(2)-succinyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028820", "l": "Formation of VAF (virus-activated factor) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41174", "l": "1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O <=> 2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68907", "l": "3-phenylpropanoate + ATP + H(+) + NADPH <=> 3-phenylpropanal + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11766", "l": "methylamine + urea => H2O + methylguanidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799350", "l": "Exocytosis of specific granule membrane proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508513", "l": "PTK2B binds JAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52541", "l": "cytidine + phosphate => alpha-D-ribose 1-phosphate + cytosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23171", "l": "coformycin + NADP(+) <=> 8-oxocoformycin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000120", "l": "CBLIF binds RCbl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607756", "l": "TRAF6 oligomer autoubiquitinates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63629", "l": "ATP + hexadecanoate + holo-[ACP] => AMP + diphosphate + hexadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35864", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-532549", "l": "MPI isomerises Fru6P to Man6P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199112", "l": "CRTAM binds to NECL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73204", "l": "D-glucose(out) + H(+)(in) => D-glucose(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52812", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2995334", "l": "COX15 transforms heme O to heme A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66447", "l": "hexan-3-one + NADP(+) <=> (E)-4-hexen-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52420", "l": "O-phospho-L-serine + thiosulfate = phosphate + S-sulfo-L-cysteine", "d": []}, {"i": "EC:2.8.5.1", "l": "\"S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.96", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000249", "l": "C-22 sterol desaturase activity", "d": ["Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25313", "l": "glyoxylate + H2O2 => glycolate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42033", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694445", "l": "nsp16 binds nsp10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50473", "l": "anthraniloyl-CoA + H(+) + malonyl-CoA => (2-aminobenzoyl)acetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69269", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate => an alkenyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044585", "l": "cellobiose binding", "d": ["Binding to cellobiose, a disaccharide that represents the basic repeating unit of cellulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42247", "l": "H(+) + malonyl-[ACP] + propanoyl-CoA <=> 3-oxopentanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102265", "l": "tRNA-dihydrouridine47 synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil47 in tRNA + NAD(P) = H+ + a uracil47 in tRNA + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69812", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56292", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.75", "l": "\"fenbendazole monooxygenase (4'-hydroxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675790", "l": "MTORC1 dissociates from ULK complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.65", "l": "\"levanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706354", "l": "Ubiquitination of FLT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74623", "l": "AMP(in) + UMP(out) = AMP(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58353", "l": "2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2 => CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10251", "l": "dUTP + H2O <=> diphosphate + dUMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055053", "l": "mannose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: mannose + H+ = mannose + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39891", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine = dTDP + H(+) + vancomycin", "d": []}, {"i": "EC:2.4.1.322", "l": "\"devancosaminyl-vancomycin vancosaminetransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018544", "l": "4-carboxy-4'-sulfoazobenzene reductase activity", "d": ["Catalysis of the reaction: 4-carboxy-4'-sulfoazobenzene + 4 H+ + 4 e- = 4-aminobenzoate + 4-aminobenzenesulfonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106286", "l": "(E)-caffeate-CoA ligase activity", "d": ["Catalysis of the reaction: (E)-caffeate + ATP + CoA = (E)-caffeoyl-CoA + AMP + diphosphate."]}, {"i": "RHEA:36299", "l": "(E)-caffeate + ATP + CoA = (E)-caffeoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847968", "l": "PTEN binds FRK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18528", "l": "3-methylbutanol + NADP(+) <=> 3-methylbutanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210426", "l": "Glutamate synaptic vesicle docking and priming (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429497", "l": "SLP-76 stimulates PLC gamma 2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22428", "l": "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = 2 H2O + isopenicillin N", "d": []}, {"i": "EC:1.21.3.1", "l": "\"isopenicillin-N synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22302", "l": "a flavonol 3-O-beta-D-glucoside + H(+) + UDP => a flavonol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851866", "l": "MET binds RANBP10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875591", "l": "DOCK7 activates RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52440", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose = a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675194", "l": "Activated MAPK phosphorylates RAF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35014", "l": "D-fucose(in) + H(+)(in) <=> D-fucose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62884", "l": "O2 + 4 semiviriditoxin = 2 (M)-viriditoxin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52139", "l": "a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O <=> a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13954", "l": "a D-aminoacyl-tRNA + H2O => a D-alpha-amino acid + a tRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669878", "l": "Sunitinib-resistant KIT mutants do not bind sunitinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.161881760686384", "identifiers": [{"i": "GO:0004520", "l": "DNA endonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51170", "l": "(R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine => (R)-adrenaline + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450325", "l": "c-FOS activation by phospho ERK1/2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12219", "l": "9H-fluoren-9-ol + NAD(+) <=> 9H-fluoren-9-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48606", "l": "2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+) => 2,3-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35162", "l": "(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O <=> (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19072", "l": "(R)-S-lactoylglutathione <=> glutathione + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952419", "l": "SMURFs ubiquitinate RUNX3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38496", "l": "a triacylglycerol + H2O => a 1,3-diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801762", "l": "REG3A oligomerize to form a pore complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870466", "l": "RGGT:CHM binds RABs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43557", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61315", "l": "germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2995330", "l": "COX10 transforms heme to heme O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25773", "l": "2-oxoglutarate + L-asparagine + O2 => (2S,3S)-3-hydroxyasparagine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015413", "l": "ABC-type nickel transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44631", "l": "L-dihydroanticapsin + NAD(+) <=> H(+) + L-anticapsin + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963915", "l": "1,25(OH)2D binds VDR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18910", "l": "2,4,6-trichlorophenol + S-adenosyl-L-methionine => 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374664", "l": "Phosphorylation and activation of Ezrin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877414", "l": "FOXP3 in complex with RUNX1 binds the CTLA4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805059", "l": "CK2:FACT phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396029", "l": "Latent TGF-beta-3 binds integrins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31526", "l": "2-oxoglutarate + 2 H(+) + O2 <=> 3 CO2 + ethene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050068", "l": "lysine carbamoyltransferase activity", "d": ["Catalysis of the reaction: L-lysine + carbamoyl phosphate = L-homocitrulline + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097258", "l": "20-hydroxy-leukotriene B4 omega oxidase activity", "d": ["Catalysis of the reaction: 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-oxo-leukotriene B4 + H+ + 2 H2O + oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3878123", "l": "Initiation of SAHF formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202947", "l": "Caspase mediated cleavage of APC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202328", "l": "Translocation of PKC theta to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29859", "l": "5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28463", "l": "pyridoxal(in) => pyridoxal(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-688137", "l": "RIP2 is K63 polyubiquitinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50847", "l": "(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013021", "l": "GDIs block activation of RHOB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33437", "l": "episterol => fecosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042389", "l": "omega-3 fatty acid desaturase activity", "d": ["Catalysis of the introduction of an omega-3 double bond into the fatty acid hydrocarbon chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378975", "l": "Follitropin is a heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21338", "l": "4-pyridoxolactone + H(+) + NADH => NAD(+) + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44960", "l": "(2E)-decenoyl-CoA + H(+) + NADPH = decanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848930", "l": "PTK6 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10018", "l": "(E)-sinapate + choline + H(+) => H2O + O-sinapoylcholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29844", "l": "ATP + CoA + propanoate => ADP + phosphate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53078", "l": "5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32042", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate <=> AMP + ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15109", "l": "2-dehydro-3-deoxy-D-gluconate + NADP(+) = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.126", "l": "\"2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15730", "l": "D-mannonate + NAD(+) => H(+) + keto-D-fructuronate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000122", "l": "CD320 binds extracellular TCN2:RCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69849", "l": "a uridine in RNA + H(+) + NADPH => a 5,6-dihydrouridine in RNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709883", "l": "BIL:ALB scavenges O2.- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36100", "l": "benzoate + S-adenosyl-L-methionine => methyl benzoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28202", "l": "2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate = 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.7.7", "l": "\"ferredoxin:protochlorophyllide reductase (ATP-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28456", "l": "N(6)-(D-fructosyl)-L-lysine(out) => N(6)-(D-fructosyl)-L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061607", "l": "peptide alpha-N-propionyltransferase activity", "d": ["Catalysis of the reaction: propionyl-CoA + peptide = CoA + N-alpha-propionylpeptide. This reaction is the propionylation of the N-terminal amino acid residue of a peptide or protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74957", "l": "a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + diphosphate => a (3R)-3-isocyanyl-fatty acid + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72981", "l": "asterriquinone C1 + diphosphate => didemethylasterriquinone D + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034024", "l": "glutamate-putrescine ligase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP + putrescine = gamma-L-glutamylputrescine + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41779", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0) <=> CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14461", "l": "(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.193", "l": "\"sarsapogenin 3beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19209", "l": "codeine + NADP(+) = codeinone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080075", "l": "spermidine:feruloyl CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of a feruloyl group to a nitrogen atom on the spermidine molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48199", "l": "H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625416", "l": "Anterograde IFT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51181", "l": "cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57438", "l": "acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => guaethol + O2 + reduced [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9681616", "l": "AP2 binds chlorpromazine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13666", "l": "GTP => 3',5'-cyclic GMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33861", "l": "H2O + versicolorin B => (2S-3S)-versiconal hemiacetal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74258", "l": "XDH oxidizes xanthine to form urate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60557", "l": "uridine(35) in tRNA(Tyr) => pseudouridine(35) in tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507875", "l": "Aquaporins passively transport urea into cells (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53652", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451311", "l": "Activation of Ca-permeable Kainate receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-982810", "l": "JAK2 phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51507", "l": "a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose <=> a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113402", "l": "Formation of DSIF:NELF:early elongation complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400143", "l": "Fatty acid ligands activate PPARA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809254", "l": "MTMR8 binds MTMR9 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22300", "l": "a flavonol + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.91", "l": "\"flavonol 3-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209381", "l": "AP-1 transcription factor, JRA:KAY, is phosphorylated by phosphorylated BSK kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-901047", "l": "Binding of ERp57 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69127", "l": "Formation of the Flap Intermediate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70361", "l": "CoA + H(+) + N-acyl-3-oxosphinganine => 3-oxosphinganine + a fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25306", "l": "7,8-dihydroneopterin + phosphate = 7,8-dihydroneopterin 3'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031700", "l": "adrenomedullin receptor binding", "d": ["Binding to an adrenomedullin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70703", "l": "D-cycloserine(in) + H(+)(in) = D-cycloserine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16179", "l": "2 H(+) + NADH + retinoate => H2O + NAD(+) + retinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351913", "l": "Caspase-mediated cleavage of TJP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67024", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.296", "l": "\"methyltransferase cap2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68842", "l": "(6R,7S)-2,2,6-trimethyl-10-methylenebicyclo[5.4.0]undec-1(11)-ene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13925", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38031", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) = (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54290", "l": "diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein] => ATP + L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433418", "l": "Phosphorylation of JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031730", "l": "CCR5 chemokine receptor binding", "d": ["Binding to a CCR5 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21110", "l": "2-methylbutanal + CO2 => (S)-3-methyl-2-oxopentanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9613497", "l": "Unwinding DNA for the nascent transcript (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35391", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683792", "l": "p-T68-CHEK2 autophosphorylates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50109", "l": "hexadecanoyl-CoA + taurine => CoA + H(+) + N-hexadecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047511", "l": "(S)-methylmalonyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: (S)-methylmalonyl-CoA + H2O = CoA + H+ + methylmalonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5251942", "l": "Hikeshi binds HSP70s:ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25253", "l": "ATP + N-acetyl-D-mannosamine = ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693243", "l": "RHOD translocates to the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416683", "l": "SEMA3E binds to PLXND1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75240", "l": "TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8   (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13186", "l": "H2O + 4 porphobilinogen => hydroxymethylbilane + 4 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008412", "l": "CDK4 phosphorylates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654404", "l": "Activated FGFR2 binds SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69532", "l": "(2S)-2-amino-4-deoxychorismate = 4-amino-4-deoxychorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19114", "l": "(8Z,11Z,14Z)-heptadecatrienal + A + H2O => (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29360", "l": "H2O + UMP => phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174493", "l": "Glycosylation of ENV polyprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23066", "l": "an aldehyde + FMN + 2 H(+) + H2O + sulfite => an alkanesulfonate + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15864", "l": "3-ADP-2-phosphoglycerate + H2O <=> 3-ADP-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56080", "l": "[Rab1 protein]-L-serine + CDP-choline = [Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635854", "l": "GLI2,3 are degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388605", "l": "POMC(138-176) binds MC2R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65594", "l": "4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56435", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72442", "l": "(E)-ferulate + ATP + H(+) <=> (E)-feruloyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34537", "l": "1-deoxy-3-dehydrosphinganine + CO2 + CoA => H(+) + hexadecanoyl-CoA + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419644", "l": "Transphosphorylation of pLIMK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392834", "l": "Activation of EPACs by cAMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52871", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate <=> 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59059", "l": "2 methanethiol + NAD(+) <=> dimethyl disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69397", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810376", "l": "ING2 binds PI5P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051738", "l": "xanthophyll binding", "d": ["Binding to xanthophylls, any of several neutral yellow to orange carotenoid pigments containing oxygen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047724", "l": "inosine nucleosidase activity", "d": ["Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29944", "l": "2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) => 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34674", "l": "3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10877", "l": "4-hydroxybenzoate + H(+) => CO2 + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983153", "l": "E1 mediated ubiquitin activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617596", "l": "BAG6:GET4:UBL4A binds mislocalized membrane protein:SGTA and ASNA1:ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875523", "l": "MET binds TNS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20809", "l": "acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-7-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033886", "l": "cellulose-polysulfatase activity", "d": ["Catalysis of the hydrolysis of the 2- and 3-sulfate groups of the polysulfates of cellulose and charonin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-481010", "l": "Surface deployment of platelet dense granule membrane components (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35046", "l": "N-(4-aminobenzoyl)-L-glutamate(in) <=> N-(4-aminobenzoyl)-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426152", "l": "SREBP1A,2 binds the IDI1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193964", "l": "CYP21A2 21-hydroxylates PROG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14881", "l": "3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+) = asparagusate + H(+) + NADH", "d": []}, {"i": "EC:1.8.1.11", "l": "\"asparagusate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41311", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30256", "l": "2 a ubiquinol + O2 => 2 a ubiquinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40052", "l": "chorismate => 3-[(1-carboxyvinyl)-oxy]benzoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39945", "l": "a 1,2-diacylglycerol + CoA => a 1-acylglycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69040", "l": "(2S)-2-nitrosobutanedioate + H(+) + NADPH + O2 = 2-nitrobutanedioate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190065", "l": "Activated TrkA receptor internalizes to endosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69536", "l": "alpha-D-tagatopyranose 1-phosphate + ATP = ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.234", "l": "\"D-tagatose-1-phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49962", "l": "5,10-dihydrophenazine + CO2 + H2O2 => (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416358", "l": "G alpha (q) inhibits PI3K alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877338", "l": "RUNX1 and NFATC2 bind the IL2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944266", "l": "Association of procollagen type XI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420975", "l": "Ca impermeable AMPA receptor ligand binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13636", "l": "ATP + L-glutamate + putrescine <=> ADP + gamma-L-glutamylputrescine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.63", "l": "\"3-hydroxyphenylacetate 6-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19207", "l": "diphosphate + dUMP + NH4(+) => dCTP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51618", "l": "CO2 + dATP + H2O => ATP + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729318", "l": "CSNK1A1 phosphorylates nucleoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61558", "l": "gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802941", "l": "RAF is paradoxically phosphorylated downstream of kinase-inactive RAF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730501", "l": "SARS-CoV-2 3CLpro dimer binds to STING (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51776", "l": "4-prenylphlorisobutanophenone + dimethylallyl diphosphate = deoxycohumulone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31470", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose <=> bis(beta-D-glucosyl) crocetin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58412", "l": "3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin] = H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}, {"i": "EC:2.8.1.16", "l": "\"L-aspartate semialdehyde sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.327400668044291", "identifiers": [{"i": "GO:0008276", "l": "protein methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group (CH3-) to a protein."]}, {"i": "REACT:R-HSA-9632182", "l": "PRMT1 methylates ESRs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693478", "l": "HTR1A binds HTR1A agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35657", "l": "3',3'-c-di-AMP + 2 diphosphate => 2 ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047168", "l": "isocitrate O-dihydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: caffeoyl-CoA + isocitrate = 2-caffeoylisocitrate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197958", "l": "FPGS-2 transforms THF to THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18221", "l": "1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O = a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate", "d": []}, {"i": "EC:3.1.3.59", "l": "\"alkylacetylglycerophosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786190", "l": "CMBL hydrolyses OM to OLMS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53341", "l": "5,6-dihydrouridine(20) in tRNA + NAD(+) => H(+) + NADH + uridine(20) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34080", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9718360", "l": "GNRHR binds GNRHR peptide agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22040", "l": "H2O + N-formyl-L-aspartate = formate + L-aspartate", "d": []}, {"i": "EC:3.5.1.8", "l": "\"formylaspartate deformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31279", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = (2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112266", "l": "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388832", "l": "PI3K binds CD28 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48225", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O => a neolactoside nLc4Cer(d18:1(4E)) + L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20408", "l": "H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate <=> (2S,6S)-2,6-diaminoheptanedioate + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74866", "l": "(R)-salsolinol + S-adenosyl-L-methionine <=> H(+) + N-methyl-(R)-salsolinol + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213246", "l": "Disassociation of CLIP from MHC II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70288", "l": "1D-myo-inositol 3,4,6-trisphosphate + ATP => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61332", "l": "ATP + H2O + indoxyl sulfate(in) = ADP + H(+) + indoxyl sulfate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32367", "l": "4 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone = 4 Fe(II)-[cytochrome c] + 5 H(+) + L-dehydroascorbate", "d": []}, {"i": "EC:1.3.2.3", "l": "\"L-galactonolactone dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14503", "l": "2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+) => H2O + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67040", "l": "(3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + H(+) = asnovolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950778", "l": "p-Y693-STAT4 dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69412", "l": "2 glutathione + tert-butyl hydroperoxide = glutathione disulfide + H2O + tert-butanol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0005501", "l": "retinoid binding", "d": ["Binding to a retinoid, a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482770", "l": "Release of platelet secretory granule components (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34664", "l": "20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine => 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033740", "l": "hydroxylamine oxidoreductase activity", "d": ["Catalysis of the reactions: hydroxylamine + NH3 = hydrazine + H2O, and hydrazine + acceptor = N2 + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9704297", "l": "CHRM2 binds CHRM2 antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23497", "l": "5-hydroxypentanoate + acetyl-CoA => 5-hydroxy-pentanoyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.52", "l": "\"calpain-1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45464", "l": "eicosanoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z)-eicosenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.10", "l": "\"icosanoyl-CoA 5-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034932", "l": "1-methoxypyrene 6,7-monooxygenase activity", "d": ["Catalysis of the reaction: 1-methoxypyrene + O2 + 2 H+ + 2 e- = 1-methoxypyrene-6,7-oxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46830", "l": "4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162657", "l": "Inactivation of Myt1 kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31715", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691621", "l": "C5 binds C5 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32569", "l": "(1R,4S)-camphene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42949", "l": "cytidine(48) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.054311793581761", "identifiers": [{"i": "GO:0015157", "l": "oligosaccharide transmembrane transporter activity", "d": ["Enables the transfer of oligosaccharide from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51381", "l": "(9Z)-octadecenoyl-CoA + dopamine => CoA + H(+) + N-(9Z-octadecanoyl)-dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68203", "l": "1,2-dihexanoylglycerol + hexadecanoyl-CoA <=> 1,2-dihexanoyl-3-hexadecanoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981355", "l": "RASA1 binds RAS:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66983", "l": "2-methylbutanoyl-CoA + H2O <=> 2-methylbutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48796", "l": "O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858480", "l": "WNT-dependent phosphorylation of DVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49495", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate <=> 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46523", "l": "an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32116", "l": "2-oxoglutarate + DIBOA beta-D-glucoside + O2 => CO2 + succinate + TRIBOA beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40529", "l": "2 a ubiquinone + 4 H(+)(out) + 2 H2O(in) => 2 a ubiquinol + 4 H(+)(in) + O2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9656947", "l": "OGG1beta translocates to mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434650", "l": "MATEs mediate extrusion of xenobiotics (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604712", "l": "Initial activation of proMMP7 by trypsin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.99.-", "l": "\"Other protein kinases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40133", "l": "(9Z)-hexadecenoate + CoA + H(+) => (9Z)-hexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.142", "l": "\"limit dextrinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375384", "l": "Bombesin-like receptors bind bombesin homologues (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799350", "l": "Exocytosis of specific granule membrane proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018774", "l": "2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity", "d": ["Catalysis of the reaction: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20829", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17947", "l": "(1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.123", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63067", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + tetraacetate lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21273", "l": "ATP + glutathione + spermidine => ADP + glutathionylspermidine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15597", "l": "a Fe(III)-siderophore(out) + ATP + H2O = a Fe(III)-siderophore(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799416", "l": "TP53 stimulates expression of TP53INP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62835", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047855", "l": "dihydrobunolol dehydrogenase activity", "d": ["Catalysis of the reaction: dihydrobunolol + NADP+ = bunolol + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805061", "l": "CK2 binds FACT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017797", "l": "NOTCH3 binds YBX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74865", "l": "H(+) + N-methyl-(R)-salsolinol + S-adenosyl-L-homocysteine => (R)-salsolinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15476", "l": "flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose <=> flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794348", "l": "NRXNs bind  SYTs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28238", "l": "calycosin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250947", "l": "B-WICH complex binds rDNA promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31169", "l": "3-oxotetradecanoyl-CoA + H(+) + NADH => (3S)-hydroxytetradecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67225", "l": "(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57038", "l": "(1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl](n) + D-fructose => [(1->6)-alpha-D-glucosyl](n) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33594", "l": "sphinganine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182986", "l": "CBL-mediated ubiquitination of CIN85 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11915", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) <=> 15-oxoprostaglandin E2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27953", "l": "L-phenylalanine(in) <=> L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25284", "l": "(S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67967", "l": "4-methylamino-L-phenylalanine + S-adenosyl-L-methionine <=> 4-dimethylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23264", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15036", "l": "O2 + pyridoxine <=> H2O2 + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332236", "l": "CBL neddylates TGFBR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70000", "l": "L-threonine(in) + Na(+)(in) => L-threonine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10853", "l": "dimethylallyl diphosphate + leachianone G => diphosphate + sophoraflavanone G", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018693", "l": "ethylbenzene hydroxylase activity", "d": ["Catalysis of the reaction: A + ethylbenzene + H2O = (S)-1-phenylethanol + AH(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015516", "l": "tartrate:succinate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22472", "l": "(R)-pantetheine + ATP = (R)-4'-phosphopantetheine + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.34", "l": "\"pantetheine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444171", "l": "Receptor FFAR2 binds carboxylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61701", "l": "glycyl-5'-AMP + holo-[peptidyl-carrier protein] => AMP + glycyl-[peptidyl-carrier protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710354", "l": "GSDME (1-270) binds cardiolipin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57630", "l": "H2O + ML-236C carboxylate => 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13315", "l": "formaldehyde + glycine + H2O2 => H2O + O2 + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0062179", "l": "vitamin D 23-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-23 of any form of vitamin D."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30853", "l": "D-glyceraldehyde + dihydroxyacetone phosphate => beta-D-fructose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25979", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011347", "l": "ROBO3.1 mRNA translation is positively regulated by MSI1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769383", "l": "CBY1 binds beta-catenin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980128", "l": "NOTCH1 associates with negative regulators NUMB and ITCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016936", "l": "galactoside binding", "d": ["Binding to a glycoside in which the sugar group is galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75817", "l": "ADP + H(+) + K(+)(out) + phosphate => ATP + H2O + K(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800490", "l": "ATM phosphorylates PIDD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55018", "l": "7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+) => H(+) + menthone + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31828", "l": "(2E,6E)-farnesyl diphosphate => (+)-gamma-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59648", "l": "D-xylotriono-1,5-lactone + H2O = D-xylotrionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789092", "l": "NOX2 generates superoxide anion from oxygen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37420", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803892", "l": "SFN dimer binds BAX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33149", "l": "ADP + daunorubicin(out) + H(+) + phosphate => ATP + daunorubicin(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66310", "l": "an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+) => an inositol-1-phosphoceramide + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033773", "l": "isoflavone 2'-hydroxylase activity", "d": ["Catalysis of the reaction: an isoflavone + O2 + reduced [NADPH-hemoprotein reductase] = a 2'-hydroxyisoflavone + H+ + H2O + oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694467", "l": "Spike protein forms a homotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209840", "l": "Two DITs combine to form thyroxine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59284", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = D-glucose + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26028", "l": "H2O + N(1)-acetylspermidine + O2 => 3-aminopropanal + H2O2 + N-acetylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42855", "l": "3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine <=> (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4686998", "l": "Defective MPDU1 does not promote transfer of Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 by ALG12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29590", "l": "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) <=> 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63256", "l": "1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38971", "l": "O2 + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22674", "l": "diphosphate + presqualene diphosphate => 2 (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983194", "l": "Kinesin-1 is a heterotetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55771", "l": "all-trans-retinoate + UDP-alpha-D-glucuronate <=> all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35013", "l": "D-fucose(out) + H(+)(out) => D-fucose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45013", "l": "H2O + N-octadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683772", "l": "Trimmed spike protein binds to calnexin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008835", "l": "diaminohydroxyphosphoribosylaminopyrimidine deaminase activity", "d": ["Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O + H+ = 5-amino-6-(5-phosphoribosylamino)uracil + NH4."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070976", "l": "TIR domain binding", "d": ["Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30131", "l": "H2O + octanoyl-[ACP] = H(+) + holo-[ACP] + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10466", "l": "n acetate + chitosan => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449117", "l": "TXLNA (IL14) binds syntaxin1A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25683", "l": "L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24083", "l": "ATP + L-tryptophan + tRNA(Trp) <=> AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50549", "l": "prostaglandin E1 => H2O + prostaglandin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389348", "l": "Activation of Rac1 by pVav1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35362", "l": "3-hydroxyisoheptadecanoyl-CoA <=> (2E)-15-methylhexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52845", "l": "3,4-dihydroxybenzoate + UDP-alpha-D-glucose => 1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112379", "l": "Recruitment of elongation factors to form elongation complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034862", "l": "2,6-dihydroxybenzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: 2,6-dihydroxybenzothiazole + 1/2 O2 = 2,6,7-trihydroxybenzothiazole."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54373", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-(2S,3R,9R)-pristinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015474", "l": "autotransporter activity", "d": ["Transports a passenger protein from the periplasm to the external milieu; the passenger protein and the porin are the N- and C-terminal regions of the same protein, respectively."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53561", "l": "9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205238", "l": "SHP2 interacts with p-KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57680", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.76", "l": "\"flavone synthase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647746", "l": "EML4 trimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963913", "l": "1,25(OH)2D translocates from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46286", "l": "(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69884", "l": "L-ascorbate(out) + 2 Na(+)(out) => L-ascorbate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71317", "l": "chloride(in) + L-serine(in) + 2 Na(+)(in) => chloride(out) + L-serine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870466", "l": "RGGT:CHM binds RABs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851011", "l": "TRIM27 polyubiquitinates PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814555", "l": "Integrator complex processes the 3' end of snRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090581", "l": "protein-phosphocysteine-mannosylglycerate-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannosylglycerate(out) = protein cysteine + mannosylglycerate phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54187", "l": "an N-acyl-aromatic L-alpha-amino acid + H2O <=> a carboxylate + an aromatic L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43454", "l": "4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexanoyl-CoA + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73561", "l": "dGTP(in) + UTP(out) => dGTP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015471", "l": "nucleoside-specific channel forming porin activity", "d": ["Enables the energy independent passage of nucleoside, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023027", "l": "MHC class I protein binding, via antigen binding groove", "d": ["Binding to a major histocompatibility complex class I molecules via the antigen binding groove."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450494", "l": "HuR binds mRNAs in the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73457", "l": "8-hydroxysalvigenin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + salvigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189439", "l": "ALAD condenses 2 dALAs to form PBG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44713", "l": "a 1,2-diacylglycerol + H2O => a 1-acylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088220", "l": "Endorepellin binds alpha2beta1 integrin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40249", "l": "10-carboxy-13-deoxycarminomycin + H(+) + methanol => H2O + rhodomycin D", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034829", "l": "2-hydroxydec-2,4-diene-1,10-dioate hydratase activity", "d": ["Catalysis of the reaction: 2-hydroxydec-2,4-diene-1,10-dioate + H2O = (2Z)-2,4-dihydroxydec-2-enedioate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42909", "l": "S-adenosyl-L-methionine + uridine(1939) in 23S rRNA => 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798299", "l": "TP53 stimulates E2F7 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-451033", "l": "(S)-Malate <=> Fumarate + H2O (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35656", "l": "2 ATP => 3',3'-c-di-AMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48240", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b = CMP + ganglioside GT1b + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893597", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [mitochondrial] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31888", "l": "(S)-2,3-epoxysqualene => tirucalladienol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39698", "l": "3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH <=> (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624131", "l": "UNC119B binds myristoylated proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.24", "l": "\"alpha-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1297275", "l": "CD9:Izumo Binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981713", "l": "C4b binds to cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034796", "l": "Activated NTRK3 binds PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37311", "l": "ATP + glycyl-L-glutamine(out) + H2O = ADP + glycyl-L-glutamine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51556", "l": "(S)-glaucine + S-adenosyl-L-methionine = (S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102124", "l": "gibberellin A12 16alpha,17 epoxidase activity", "d": ["Catalysis of the reaction: gibberellin A12 + O2 + H+ + NAD(P)H <=> 16alpha, 17-epoxy gibberellin A12 + H2O + NAD(P)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12331", "l": "[(1->3)-alpha-D-glucosyl](n) + phosphate <=> [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30415", "l": "H(+) + 2 NADPH + O2 + octadecanal = formate + H2O + heptadecane + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44413", "l": "3-demethylubiquinol-10 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174124", "l": "Dephosphorylation of phospho-Cdh1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58365", "l": "a medium-chain primary fatty alcohol + NADP(+) => a medium-chain fatty aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0042302", "l": "structural constituent of cuticle", "d": ["The action of a molecule that contributes to the structural integrity of a cuticle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57829", "l": "dIMP + H2O => 2-deoxy-D-ribose 5-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047666", "l": "ammonia kinase activity", "d": ["Catalysis of the reaction: ATP + NH4 = ADP + 3 H+ + phosphoramidate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45496", "l": "phycocyanobilin-L-cysteinyl(84)-[allophycocyanin alpha-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61898", "l": "betaenone A => betaenone C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709317", "l": "CO binds to free ferrohemoglobin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928620", "l": "PAK1 autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35686", "l": "hexadecasphinganine + NADP(+) <=> 3-oxohexadecasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218821", "l": "PDK1 phosphorylates PKC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209244", "l": "REL binds to DREDD in the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21311", "l": "(S)-2,3-epoxysqualene <=> cycloartenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176416", "l": "NEDD4L ubiquitin ligase binds SMAD7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106344", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP", "d": ["Catalysis of the reaction: 2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] = (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H+ + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]."]}, {"i": "RHEA:65756", "l": "2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] = (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694522", "l": "Inner coat assembly and cargo binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61648", "l": "ATP + holo-[non-ribosomal peptide synthase] + salicylate = AMP + diphosphate + salicyl-[non-ribosomal peptide synthase]", "d": []}, {"i": "EC:6.2.1.61", "l": "\"salicylate--[aryl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46488", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045148", "l": "tripeptide aminopeptidase activity", "d": ["Catalysis of the hydrolysis of a single N-terminal amino acid residue from a tripeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396337", "l": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71454", "l": "bradykinin + H2O <=> bradykinin(1-7) + L-Phe-L-Arg", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12969", "l": "a sn-glycero-3-phosphodiester + H2O = an alcohol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38251", "l": "hexadecan-1-ol + octadecanoyl-CoA = CoA + hexadecanyl octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047320", "l": "D-4-hydroxyphenylglycine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55059", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61994", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.95", "l": "\"dextran 1,6-alpha-isomaltotriosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68927", "l": "ATP + H(+) + hexanoate + NADPH <=> AMP + diphosphate + hexanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73800", "l": "SAICAR => AICAR + Fumarate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25576", "l": "3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX", "d": []}, {"i": "EC:1.3.3.4", "l": "\"protoporphyrinogen oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36296", "l": "alpha-maltose 6'-phosphate + H2O => D-maltose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13124", "l": "ATP + shikimate <=> 3-phosphoshikimate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58475", "l": "2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69127", "l": "Formation of the Flap Intermediate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54151", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene <=> 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75566", "l": "cyathadiol + O2 + reduced [NADPH--hemoprotein reductase] <=> cyathatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24903", "l": "3',3'-c-di-GMP + H2O => 5'-phosphoguanylyl(3'->5')guanosine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48257", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805035", "l": "TP53 binds STK11 and NUAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51983", "l": "an L-N,N-dihydroxypolyhomomethionine + H(+) <=> an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54275", "l": "2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16812", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate <=> pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20882", "l": "10-oxodecanoate + H(+) + NADH => 10-hydroxydecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57159", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 <=> 4-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50061", "l": "ATP + glycochenodeoxycholate(in) + H2O => ADP + glycochenodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.80", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.185", "l": "\"L-glycol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75708", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate => 10,11-epoxy-12-hydroxy-(14Z,17Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.12", "l": "\"lipid IVA 3-deoxy-D-manno-octulosonic acid transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25223", "l": "CO2 + taurine => H(+) + L-cysteate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59641", "l": "D-xylotetraose + O2 => D-xylotetraono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62149", "l": "dGTP + dTMP => dGDP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691131", "l": "CANDI binds CUL1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189406", "l": "4 PBGs bind to form HMB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55964", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13749", "l": "a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP", "d": []}, {"i": "EC:2.7.4.10", "l": "\"nucleoside-triphosphate--adenylate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35568", "l": "H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine => (9Z,12Z)-octadecadienoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70692", "l": "ornithine => putrescine + CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166817", "l": "Cleavage of C3 by C3 convertases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57827", "l": "dAMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62885", "l": "O2 + 4 semiviriditoxin => 2 (M)-viriditoxin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52498", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847977", "l": "FRK phosphorylates PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111264", "l": "Addition of nucleotides between position +11 and +30 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45402", "l": "(9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944230", "l": "Association of procollagen type XVIII (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173626", "l": "Activation of C1r (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0150025", "l": "oxidised low-density lipoprotein particle receptor activity", "d": ["Combining with an oxidised low-density lipoprotein particle and delivering the oxidised low-density lipoprotein particle into the cell via endocytosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25806", "l": "3-aminopropanal + H2O2 + spermidine => H2O + O2 + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380227", "l": "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3204303", "l": "MRE11 binds cytosolic DNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106157", "l": "peptidyl-arginine 3-dioxygenase activity", "d": ["Catalyzes the reaction: 2-oxoglutarate + [protein]-L-arginine + O2 = [protein]-(3R)-3-hydroxy-L-arginine + CO2 + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52020", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 = A + H2O + resolvin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11908", "l": "H2O + nonane-4,6-dione = butanoate + H(+) + pentan-2-one", "d": []}, {"i": "EC:3.7.1.7", "l": "\"beta-diketone hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62963", "l": "7-dehydrocholesterol(in) <=> 7-dehydrocholesterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033509", "l": "USP9X binds Ub:PEX5L (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2160874", "l": "HYAL1 hydrolyses (HA)50 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35959", "l": "H(+) + NADPH + O2 + tryprostatin B = demethoxyfumitremorgin C + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57154", "l": "(3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45116", "l": "(4R)-ipsdienol + NADP(+) = H(+) + ipsdienone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53509", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione => (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29276", "l": "L-isoleucine(in) + Na(+)(in) => L-isoleucine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57832", "l": "5-oxopentanoate + H2O + NADP(+) = glutarate + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.20", "l": "\"glutarate-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54530", "l": "D-ribose 5-phosphate => aldehydo-D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019834", "l": "phospholipase A2 inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of phospholipase A2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-555065", "l": "Formation of clathrin coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000995", "l": "RNA polymerase III general transcription initiation factor activity", "d": ["A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030987", "l": "high molecular weight kininogen receptor binding", "d": ["Binding to a high molecular weight kininogen receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214410", "l": "Monomeric PGN binds to PGRP-LE in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264622", "l": "Cho is acetylated to AcCho by CHAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29305", "l": "2 H(+)(out) + succinate(out) => 2 H(+)(in) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70996", "l": "L-cystine(out) + L-glutamate(in) => L-cystine(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66399", "l": "ATP + cholate(in) + glutathione(in) + H2O <=> ADP + cholate(out) + glutathione(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51388", "l": "acetyl-CoA + dopamine = CoA + H(+) + N-acetyl-dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33803", "l": "H2O + L-histidinal + NAD(+) = 2 H(+) + L-histidine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299318", "l": "Activation of TASK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70037", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + typhasterol => 6-deoxotyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38160", "l": "(2S,3S)-hydroxyarginine => (2S,3R)-capreomycidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65490", "l": "2',3',3'-c-tri-AMP + 3 diphosphate => 3 ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44388", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73273", "l": "H(+) + rhamnacene + S-adenosyl-L-homocysteine => rhamnetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57197", "l": "H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] => glycolate + H(+) + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54517", "l": "8-hydroxycopalyl diphosphate => (13R)-manoyl oxide + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41634", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56623", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O <=> 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.349", "l": "\"toxoflavin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701507", "l": "PTPN6 dephosphorylates JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54248", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177937", "l": "Phosphorylation of EGFR by SRC kinase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41399", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine <=> 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27813", "l": "dimethylallyl diphosphate + 2 isopentenyl diphosphate <=> (2Z,6Z)-farnesyl diphosphate + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39660", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46126", "l": "(24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661198", "l": "Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35026", "l": "hydroquinone O-beta-D-glucopyranoside(out) <=> hydroquinone O-beta-D-glucopyranoside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296233", "l": "T2Rs bind bitter-tasting compounds (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58861", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604360", "l": "Initial activation of proMMP2 by MMP14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19249", "l": "glyoxylate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800490", "l": "ATM phosphorylates PIDD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69159", "l": "spermine dialdehyde <=> acrolein + N-(4-aminobutyl)-3-aminopropanal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048495", "l": "Roundabout binding", "d": ["Binding to Roundabout (ROBO) receptor, a transmembrane receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985138", "l": "OAS2 binds viral dsRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71824", "l": "3,3'-diiodo-L-thyronine(out) => 3,3'-diiodo-L-thyronine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28113", "l": "chloride + S-adenosyl-L-methionine <=> 5'-chloro-5'-deoxyadenosine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167408", "l": "The high affinity receptor complex binds to G-protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34586", "l": "2-oxoglutarate + O2 + pentalenolactone D <=> CO2 + H2O + pentalenolactone E + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73514", "l": "2-oxoglutarate + 8-hydroxysalvigenin + O2 <=> CO2 + formaldehyde + pilosin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080081", "l": "4-methylumbelliferyl-beta-D-glucopyranoside beta-glucosidase activity", "d": ["Catalysis of the hydrolysis of glucosidic link in 4-methylumbelliferyl-beta-D-glucopyranoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612493", "l": "EGR-dependent NAB2 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852337", "l": "GTSE1 binds TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55251", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64452", "l": "L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.371", "l": "\"[histone H3]-lysine(27) N-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51307", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate <=> (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051264", "l": "mono-olein transacylation activity", "d": ["Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789218", "l": "Hypochlorous acid (HOCl) reacts with unsaturated lipid to form lipid chlorohydrins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66291", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13643", "l": "H2O + methanol + NADP(+) => H(+) + methane + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.916538309327947", "identifiers": [{"i": "GO:0004812", "l": "aminoacyl-tRNA ligase activity", "d": ["Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP."]}, {"i": "EC:6.1.1.-", "l": "\"Ligases forming aminoacyl-tRNA and related compounds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.2", "l": "\"ABC-type oligosaccharide transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051909", "l": "acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate", "d": ["Catalysis of the reaction: 3-hydroxypropenoate = propynoate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59682", "l": "D-maltopentaono-1,5-lactone + H2O2 => D-maltopentaose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36522", "l": "H(+) + hexacosanoyl-CoA + malonyl-CoA <=> 3-oxooctacosanyol-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48317", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b => a ganglioside GD1alpha + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791058", "l": "Expression of Cullin-7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362549", "l": "Hh-Np traffics to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030786", "l": "(RS)-norcoclaurine 6-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0017154", "l": "semaphorin receptor activity", "d": ["Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47391", "l": "a tetradecanoate ester + H2O <=> an aliphatic alcohol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4332235", "l": "CBL binds TGFBR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507868", "l": "Aquaporins passively transport water into cells (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-990489", "l": "Kinesin-13 is a dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140696", "l": "factor V -> factor Va + factor V activation peptide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65467", "l": "2-methylbutan-1-ol + butanoyl-CoA <=> 2-methylbutyl butanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794345", "l": "NLGNs binds PSD-95 subfamily members (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61622", "l": "[(1->2)-beta-D-mannosyl](n+1) + GDP + H(+) => [(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13306", "l": "(E)-sinapate + UDP-alpha-D-glucose => 1-O-(trans-sinapoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.49", "l": "\"glucose-6-phosphate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41907", "l": "3-oxohexadecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322429", "l": "XIAP monoubiquinates TLE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70597", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA => a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55030", "l": "an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106008", "l": "2-oxoglutaramate amidase activity", "d": ["Catalysis of the reaction: 2-oxoglutaramate + H2O = 2-oxoglutarate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17001", "l": "amidinoproclavaminate + H2O = proclavaminate + urea", "d": []}, {"i": "EC:3.5.3.22", "l": "\"proclavaminate amidinohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0032356", "l": "oxidized DNA binding", "d": ["Binding to a DNA region containing an oxidized residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417114", "l": "Assembly of telomerase RNP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044583", "l": "cellotriose binding", "d": ["Binding to cellotriose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977392", "l": "Expression of CEBPD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20280", "l": "acetyl-CoA + an N-hydroxyarylamine <=> an N-acetoxyarylamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37586", "l": "D-lysine + H2O + O2 <=> 6-amino-2-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16348", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41895", "l": "(3R)-hydroxytetradecanoyl-[ACP] <=> (2E)-tetradecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.162", "l": "\"aldose beta-D-fructosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420980", "l": "Activation of Ca permeable AMPA receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52643", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA <=> (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806629", "l": "Formation of tonofilament bundles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52569", "l": "epitestosterone + UDP-alpha-D-glucuronate => epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66856", "l": "(2E)-geranyl diphosphate + 3 isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70467", "l": "2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in double-stranded DNA + H2O + O2 = a 2'-deoxycytidine in double-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016499", "l": "orexin receptor activity", "d": ["Combining with orexin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163090", "l": "Elongation Of The Telomeric Chromosome End (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19948", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507875", "l": "Aquaporins passively transport urea into cells (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68906", "l": "3-phenylpropanal + AMP + diphosphate + NADP(+) => 3-phenylpropanoate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354087", "l": "Recruitment of GRB2 to p-PTK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936590", "l": "sulfur transfer to carrier protein (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062189", "l": "anandamide 14,15 epoxidase activity", "d": ["Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]."]}, {"i": "RHEA:53148", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389348", "l": "Activation of Rac1 by pVav1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627072", "l": "RHOQ binds GOPC:CFTR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48600", "l": "[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.13", "l": "\"(6-4)DNA photolyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13599", "l": "agmatine + urea => 1,4-diguanidinobutane + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60762", "l": "CoA + jasmolin II => (1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199404", "l": "CD40L binds CD40 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53904", "l": "ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L-threonyl-[tau protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58251", "l": "5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O <=> ADP-D-ribose + H(+) + L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204169", "l": "PDP dephosphorylates p-lipo-PDH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19034", "l": "an N-acyl-D-glucosamine => an N-acyl-D-mannosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187608", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59119", "l": "[protein]-dithiol + O2 <=> [protein]-disulfide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706315", "l": "Active FLT3 binds to SH2B3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30411", "l": "benzoyl-CoA + benzyl alcohol = benzyl benzoate + CoA", "d": []}, {"i": "EC:2.3.1.196", "l": "\"benzyl alcohol O-benzoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24810", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate => 3-methyl-2-oxobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72851", "l": "ADP(out) + AMP(in) = ADP(in) + AMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37444", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47970", "l": "ganglioside GM3 + N-acetyl-beta-D-galactosamine => ganglioside GM2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11615", "l": "H2O + L-glutamate + NADP(+) <=> 2-oxoglutarate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032054", "l": "LXA4/B4 translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68867", "l": "H2O + isomaltose <=> alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26509", "l": "(9Z)-octadecenamide + H2O <=> (9Z)-octadecenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53115", "l": "3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) <=> 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102799", "l": "glucosinolate glucohydrolase activity", "d": ["Catalysis of the reaction: H2O + a glucosinolate = alpha-D-glucose + a thiohydroximate-O-sulfate. Glucosinolates are a subclass of thioglucosides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10934", "l": "2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+) => ATP + L-aspartate + L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24565", "l": "a 3-oxo acid + succinyl-CoA => a 3-oxoacyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58299", "l": "25-substituted-cholesterol + beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine <=> 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40867", "l": "(9E)-octadecenoyl-CoA + FAD + H(+) = (2E,9E)-octadecadienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0045703", "l": "ketoreductase activity", "d": ["Catalysis of the reduction of a ketone group to form the corresponding alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37062", "l": "adenosine(37) in tRNA + L-threonylcarbamoyladenylate <=> AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9732629", "l": "PPARG binds PPARG agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418850", "l": "Activation of Cdc42 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29210", "l": "a menaquinol(in) + dimethyl sulfoxide(out) <=> a menaquinone(in) + dimethyl sulfide(out) + H2O(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52655", "l": "lanosterol + S-adenosyl-L-methionine <=> eburicol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66620", "l": "5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.57", "l": "\"aromatic-amino-acid transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42082", "l": "all-trans-retinoate + 2 H(+) + NADH => all-trans-retinal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42787", "l": "adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26449", "l": "3-oxopropanoate + CoA + NADP(+) <=> H(+) + malonyl-CoA + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.77", "l": "\"anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380586", "l": "loading of Serotonin in synaptic vesicles (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16178", "l": "H2O + NAD(+) + retinal => 2 H(+) + NADH + retinoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247849", "l": "WLS dissociates from retromer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55603", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose <=> a mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134946", "l": "DDX41 ubiquitination by TRIM21 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55045", "l": "(3E,5Z)-tetradecadienoyl-CoA + H2O => (3E,5Z)-tetradecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44079", "l": "ATP + CoA + pentadecanoate <=> AMP + diphosphate + pentadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61129", "l": "O2 + quercetin + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420121", "l": "SFKs phosphorylate PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70565", "l": "2''-O-hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67544", "l": "(9Z)-tetradecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66597", "l": "O2 + 2 tyramine => 2 dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852716", "l": "Thrombin, ELANE cleave C5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21665", "l": "4-nitrophenyl phosphate + H2O => 4-nitrophenol + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14585", "l": "gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662466", "l": "XYLB phosphorylates D-xylulose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24358", "l": "a 2-acyl-sn-glycero-3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676160", "l": "AAMP binds NOD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654404", "l": "Activated FGFR2 binds SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42827", "l": "2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 <=> H2O + 2 NAD(+) + tetracenomycin C", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052578", "l": "alpha-farnesene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,E)-alpha-farnesene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74095", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66758", "l": "ADP + domoate(out) + H(+) + phosphate => ATP + domoate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28140", "l": "streptothricin F acid => H2O + streptothricin F", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46164", "l": "a quinone + H(+) + NADPH = a quinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667563", "l": "AVPR2 bind desmopressin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18929", "l": "AH2 + O2 + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O", "d": []}, {"i": "EC:1.14.99.35", "l": "\"thiophene-2-carbonyl-CoA monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31275", "l": "(S)-3-hydroxy-2-methylpropanoate + NAD(+) = (S)-methylmalonate semialdehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680389", "l": "CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15096", "l": "2-oxoglutarate + L-tyrosine <=> 3-(4-hydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37331", "l": "H2O + L-methionyl-L-alanine = L-alanine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18358", "l": "NADP(+) + tropine => H(+) + NADPH + tropinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35513", "l": "glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8865107", "l": "MICAL1 produces NADP+, H2O2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19693", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) = 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.100", "l": "\"5-formyl-3-hydroxy-2-methylpyridine 4-carboxylate 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56604", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170964", "l": "FRS2 binds to active TrkA receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71097", "l": "2 Na(+)(in) + pregnenolone sulfate(in) => 2 Na(+)(out) + pregnenolone sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61644", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine = 2 Fe(III)-[cytochrome b5] + H2O + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26098", "l": "(4R)-limonene + H(+) + NADPH + O2 => H2O + limonene 1,2-epoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381091", "l": "IRE1 dimer autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034904", "l": "5-chloro-2-oxopent-4-enoate hydratase activity", "d": ["Catalysis of the reaction: 5-chloro-2-oxopent-4-enoate + H2O = 5-chloro-4-hydroxy-2-oxopentanate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40634", "l": "H2O + trioctadecanoylglycerol <=> 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42760", "l": "D-glyceraldehyde 3-phosphate + H2O + NAD(+) = (2R)-3-phosphoglycerate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46459", "l": "5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH <=> 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34246", "l": "GTP + H(+) + Mo-molybdopterin <=> diphosphate + Mo-molybdopterin guanine dinucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13922", "l": "ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.3.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051721", "l": "protein phosphatase 2A binding", "d": ["Binding to protein phosphatase 2A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626914", "l": "α2-agonists bind ADRA2A,B,C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003977", "l": "UDP-N-acetylglucosamine diphosphorylase activity", "d": ["Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23521", "l": "acetyl-CoA + propanoate => acetate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12074", "l": "a (2S)-2-hydroxycarboxylate + a halide anion + H(+) => an (S)-2-haloacid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0051011", "l": "microtubule minus-end binding", "d": ["Binding to the minus end of a microtubule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034800", "l": "trinitrophenol dihydride denitratase activity", "d": ["Catalysis of the reaction: trinitrophenol dihydride Meisenheimer complex (aci form) = 2,4-dinitrophenol hydride Meisenheimer complex + NO2. Trinitrophenol is also known as TNP and dinitrophenol is also known as DNP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202127", "l": "eNOS synthesizes NO (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.11", "l": "\"ribonuclease Z\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9762333", "l": "ANGPTL4 binds to CDH11v (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046569", "l": "glyoxal oxidase activity", "d": ["Catalysis of the reaction: glyoxal + O2 + H2O = glyoxalate + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617457", "l": "HOXB1 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416562", "l": "p190RhoGAP binds Plexin-B1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26112", "l": "UDP-N-acetyl-alpha-D-glucosamine => H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687088", "l": "PKA phosphorylates MAPKAPK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31350", "l": "(+)-abscisic acid D-glucopyranosyl ester + H2O <=> 2-cis-(+)-abscisate + beta-D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19502", "l": "4-guanidinobutanoate + H2O => 4-aminobutanoate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28335", "l": "dATP + H2O => dAMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77081", "l": "Formation of the CE:GMP intermediate complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58862", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430347", "l": "MigFilin associates with Filamin and F-actin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004080", "l": "biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming))."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018624", "l": "toluene dioxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46055", "l": "a 3'-end uridylyl-uridine-RNA <=> a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685838", "l": "CX3 complex binds D-loop structures (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803989", "l": "Nitric oxide and O2 react to NO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43020", "l": "L,L-cystathionine = 2-aminoprop-2-enoate + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29085", "l": "oxaloacetate + ubiquinol-8 => (S)-malate + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68686", "l": "adenosine 3',5'-bisphosphate + H(+) + testosterone 17-O-(3-sulfo-beta-D-glucuronate) => 3'-phosphoadenylyl sulfate + testosterone 17-O-(beta-D-glucuronate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39885", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH => dTDP-6-deoxy-alpha-D-allose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61501", "l": "delphinidin + UDP-alpha-D-glucose => delphinidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617483", "l": "HOXA2 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-984671", "l": "Chromokinesins form dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46760", "l": "2,4-dinitrotoluene + NADH + O2 = 4-methyl-5-nitrocatechol + NAD(+) + nitrite", "d": []}, {"i": "EC:1.14.12.24", "l": "\"2,4-dinitrotoluene dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62864", "l": "7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine = 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050305", "l": "strombine dehydrogenase activity", "d": ["Catalysis of the reaction: N-(carboxymethyl)-D-alanine + H2O + NAD+ = glycine + H+ + NADH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444691", "l": "Prokineticin receptors bind prokineticin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17208", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11660", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol", "d": []}, {"i": "EC:3.5.1.89", "l": "\"N-acetylglucosaminylphosphatidylinositol deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001164", "l": "RNA polymerase I core promoter sequence-specific DNA binding", "d": ["Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36866", "l": "(9Z)-octadecenoyl-CoA + AH2 + O2 <=> (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871373", "l": "BMX phosphorylates RUFY1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080116", "l": "glucuronoxylan glucuronosyltransferase activity", "d": ["Catalysis of the transfer of glucuronate to the xylan backbone of glucuronoxylan molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12814", "l": "L-glutamate => D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31634", "l": "2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate <=> phosphate + pseudaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004671", "l": "protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781922", "l": "USP13 binds UFD1L:SKP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032770", "l": "Translocation of YAP1 to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874195", "l": "MBTPS2 (S2P) cleaves CREB3L4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018826", "l": "RHOT2 hydrolyzes GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17699", "l": "5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine => pyridine + thiamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18882", "l": "ATP + histamine + L-glutamate => ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10760", "l": "citrate = acetate + oxaloacetate", "d": []}, {"i": "EC:4.1.3.6", "l": "\"citrate (pro-3S)-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165195", "l": "GTP loading by Rheb (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12506", "l": "3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH => (3R)-1,4-thiomorpholine-3-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685906", "l": "Polyadenylation of SARS-CoV-1 subgenomic mRNAs (plus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429415", "l": "SYK binds to integrin alphaIIb beta3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5444511", "l": "Formation of MSH2:MSH3 Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53330", "l": "2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP => H2O + UDP-2,3-diacyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442739", "l": "PDPK1 phosphorylates RSKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13956", "l": "a D-aminoacyl-tRNA + H2O <=> a D-alpha-amino acid + a tRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193706", "l": "Production of ceramide which can activate JNK and other targets (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75081", "l": "Formation of AT-AC B Complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66506", "l": "1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60319", "l": "N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008820", "l": "cobinamide phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: adenosylcobinamide phosphate + GTP + 2 H+ = adenosylcobinamide-GDP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102375", "l": "11-oxo-beta-amyrin 30-oxidase activity", "d": ["Catalysis of the reaction: 11-oxo-beta-amyrin + 3 NADPH + 3 O2 + 2 H+ <=> glycyrrhetinic acid + 3 NADP + 4 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948651", "l": "miR-106a,(miR106b) microRNA binds CNOT6L mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63458", "l": "(2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+) => (2E,6E,10E)-geranylgeraniol + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67764", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027044", "l": "CYP4 ω-oxidises 14(R)-HDHA to MaR-L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33458", "l": "4alpha-carboxyzymosterol + NADP(+) <=> CO2 + NADPH + zymosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33957", "l": "DIBOA beta-D-glucoside + H(+) + UDP => DIBOA + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65657", "l": "A + cholest-1,4-dien-3-one + H2O => 25-hydroxycholest-1,4-dien-3-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41811", "l": "(3R)-hydroxybutanoyl-[ACP] <=> (2E)-butenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5099899", "l": "WNT5A binds FZD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.58", "l": "\"longifolene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229348", "l": "Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71303", "l": "RPE dimers isomerise RU5P to XY5P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692809", "l": "CDC42 binds effectors at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982775", "l": "Growth hormone receptor dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68964", "l": "2-hydroxyoctadecanoate + O2 = 2-oxooctadecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761844", "l": "NFE2L2-dependent IDH1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132065", "l": "C1r activates C1s component within C1 complement complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396399", "l": "Fibrillins bind BMPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31151", "l": "H2O + L-selenocystathionine = 2-oxobutanoate + L-selenocysteine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174121", "l": "Association of Securin with Cdc20:APC/C complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018568", "l": "3,4-dihydroxyphenanthrene dioxygenase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxyphenanthrene + O2 = H+ + 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444691", "l": "Prokineticin receptors bind prokineticin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449087", "l": "CD4 binds Interleukin-16 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5195402", "l": "CDK1 phosphorylates LPIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71839", "l": "dehydroepiandrosterone 3-sulfate(out) = dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432897", "l": "ILK interacts with beta-1 integrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23920", "l": "(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55061", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] => a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66001", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951500", "l": "Dissociation of CANX from nonameric complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635854", "l": "GLI2,3 are degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17840", "l": "2-carboxy-D-arabinitol 1-phosphate + H2O <=> 2-carboxy-D-arabinitol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54053", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + tau-cadinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47979", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62549", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141159", "l": "TNF-mediated dimerization of procaspase-8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22075", "l": "ATP + L-ribulose <=> ADP + H(+) + L-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004419", "l": "hydroxymethylglutaryl-CoA lyase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805285", "l": "PLK3 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39883", "l": "dTDP-6-deoxy-alpha-D-allose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60300", "l": "N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20183", "l": "6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP => alpha-D-mannose derivative + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43173", "l": "guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34402", "l": "9-cis-beta-carotene + O2 <=> 9-cis-10'-apo-beta-carotenal + beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68283", "l": "L-seryl-[protein] + pentanoyl-CoA <=> CoA + O-pentanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389352", "l": "Translocation of Vav1 to CD28 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74616", "l": "UDP-alpha-D-galactose(in) + UDP-alpha-D-glucose(out) => UDP-alpha-D-galactose(out) + UDP-alpha-D-glucose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61214", "l": "H(+) + myricetin 3-O-beta-D-glucoside + UDP => myricetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24015", "l": "gamma-tocopherol + S-adenosyl-L-methionine <=> (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34229", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite => 5-nitrosalicylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29128", "l": "a menaquinol + nitrate => a menaquinone + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26408", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) <=> H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874080", "l": "SRC phosphorylates PTK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050127", "l": "N-carbamoylsarcosine amidase activity", "d": ["Catalysis of the reaction: N-carbamoylsarcosine + H2O + 2 H+ = CO2 + NH4 + sarcosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72363", "l": "chloride(out) + hydrogencarbonate(in) = chloride(in) + hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29282", "l": "H(+) + menaquinol-8 + trimethylamine N-oxide <=> H2O + menaquinone-8 + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72671", "l": "eIF5B:GTP is hydrolyzed and released (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63760", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19727", "l": "CO2 + UDP-beta-L-arabinopyranose => H(+) + UDP-alpha-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10470", "l": "acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O => D-xylulose 5-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5444516", "l": "Formation of MSH2:MSH6 Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801637", "l": "TP53 stimulates PLK2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62237", "l": "a cytidine(6-4)cytidine in DNA => a cytidine dimer in DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60146", "l": "ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate => ATP + L-glutamate + L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.24", "l": "\"mitogen-activated protein kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679029", "l": "C-ter TLR7 dimer binds HCQ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41597", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH => (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22368", "l": "L-ribulose 5-phosphate = D-xylulose 5-phosphate", "d": []}, {"i": "EC:5.1.3.4", "l": "\"L-ribulose-5-phosphate 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173636", "l": "Formation of classic pathway C5 convertase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66202", "l": "(2E)-pentenoyl-CoA + H2O2 => O2 + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56378", "l": "3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+) => 3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57479", "l": "dodecanoate + H2O2 <=> 2-hydroxydodecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22039", "l": "[phosphate](n) + D-glucose <=> [phosphate](n-1) + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981931", "l": "RAC1 and CDC42 activate PAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690461", "l": "FKBP1A binds tacrolimus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11885", "l": "3'-phosphoadenylyl sulfate + cortisol => adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727857", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to PKL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21566", "l": "a 3-oxoacyl-CoA + CoA => acetyl-CoA + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102690", "l": "isopentenyladenine UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + N(6)-dimethylallyladenine = H+ + 9-(alpha-D-glucosyl)-N(6)-isopentenyladenine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684241", "l": "Recruitment of Spike trimer to assembling virion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53626", "l": "diphosphate + tsukubadiene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54224", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphocholine = 2-(prostaglandin E2)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65923", "l": "L-kynurenine + pyruvate <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72663", "l": "De novo formation of eIF2:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33392", "l": "C20 sphinganine 1-phosphate + H2O => C20 sphinganine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12155", "l": "(3R,4S,5S,6R)-pentachlorocyclohexene <=> (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876789", "l": "CARNMT1 methylates CARN to Anserine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77077", "l": "Capping complex formation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2545203", "l": "Deacetylation of cleaved cohesin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615554", "l": "MIR137 gene expression is inhibited by MECP2 and SOX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788623", "l": "p-Y-STATs translocate to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26305", "l": "2-aminophenol + O2 = 2-aminomuconate 6-semialdehyde", "d": []}, {"i": "EC:1.13.11.74", "l": "\"2-aminophenol 1,6-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42648", "l": "(2,5-ethylene furandicarboxylate)(n) + 2 H2O = (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70202", "l": "dopaminechrome <=> 5,6-dihydroxyindole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22745", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202726", "l": "F11R dimerises (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62733", "l": "(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) => (+)-isomalbrancheamide D + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29178", "l": "2 O2 + ubiquinol-8 <=> 2 H(+) + 2 superoxide + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32181", "l": "dipicolinate + H(+) + NADH => (S)-2,3-dihydrodipicolinate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019875", "l": "6-aminohexanoate-dimer hydrolase activity", "d": ["Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029453", "l": "Phosphorylation of VAV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41473", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56750", "l": "an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75059", "l": "chloride(out) + 2 hydrogencarbonate(in) + K(+)(in) = chloride(in) + 2 hydrogencarbonate(out) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39412", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA => (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685953", "l": "SIRT6 deacetylates RBBP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10671", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) <=> 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.-", "l": "\"Peptidyl peptide hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11597", "l": "H(+) + orotidine 5'-phosphate => CO2 + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35253", "l": "ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(out) + H(+) + phosphate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64484", "l": "acetyl-CoA + 6 H(+) + holo-[ACP] + 6 malonyl-CoA = 3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390912", "l": "HRH1 binds hist (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204813", "l": "Interaction of Tie2 and Grb14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874979", "l": "ACBD3 binds GOLGB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57721", "l": "ATP + 4 H(+)(in) + H2O => ADP + 5 H(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15837", "l": "L-glutamate + methylamine = N-methyl-L-glutamate + NH4(+)", "d": []}, {"i": "EC:2.1.1.21", "l": "\"methylamine--glutamate N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382055", "l": "Grb7 binds to the active PDGF receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60886", "l": "(N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46794", "l": "an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56852", "l": "reumycin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + toxoflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9005980", "l": "IL21 binds IL21R:JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54386", "l": "a 3-oxo-Delta(4)-steroid + H(+) + NADPH => a 3-oxo-5alpha-steroid + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75973", "l": "H(+) + NADPH + neomorphinone => NADP(+) + neomorphine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693598", "l": "ATM phosphorylates NBN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419426", "l": "Cannabinoid receptors can bind cannabinoids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047493", "l": "ceramide cholinephosphotransferase activity", "d": ["Catalysis of the reaction: CDP-choline + ceramide = CMP + H+ + sphingomyelin."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050605", "l": "superoxide reductase activity", "d": ["Catalysis of the reaction: superoxide + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611277", "l": "P2RY12 binds P2RY12 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008294", "l": "calcium- and calmodulin-responsive adenylate cyclase activity", "d": ["Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008419", "l": "RNA lariat debranching enzyme activity", "d": ["Catalysis of the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111879", "l": "PIP2 hydrolysis (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28471", "l": "pyridoxine(in) => pyridoxine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254291", "l": "ERBB4s80 binds STAT5A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25369", "l": "H(+) + momilactone A + NADPH => 3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694583", "l": "ABHD4 hydrolyses NAPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50915", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol <=> 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160906", "l": "20kDa HA fragments are translocated to lysosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809975", "l": "PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029476", "l": "Role of myosins in phagosome formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034417", "l": "bisphosphoglycerate 3-phosphatase activity", "d": ["Catalysis of the reaction: (2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32554", "l": "(2E)-geranyl diphosphate + H2O <=> (S)-alpha-terpineol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11720", "l": "ATP + 2 H2O + N-methylhydantoin = ADP + 2 H(+) + N-carbamoylsarcosine + phosphate", "d": []}, {"i": "EC:3.5.2.14", "l": "\"N-methylhydantoinase (ATP-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17816", "l": "D-altronate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004410", "l": "homocitrate synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H2O = CoA + H+ + homocitrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31623", "l": "L-olivosyl-oleandolide + S-adenosyl-L-methionine = H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.239", "l": "\"L-olivosyl-oleandolide 3-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36584", "l": "dTDP-alpha-D-fucose + NADP(+) => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110238", "l": "MPG glycosylase mediated recognition and binding of 3-methyladenine  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015349", "l": "thyroid hormone transmembrane transporter activity", "d": ["Enables the transfer of thyroid hormones from one side of a membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33472", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443779", "l": "Linkage of L1 with treadmilling F-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69142", "l": "Recruitment of Dna2 endonuclease (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031741", "l": "type B gastrin/cholecystokinin receptor binding", "d": ["Binding to a type B gastrin/cholecystokinin receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "62.983606478119093", "identifiers": [{"i": "GO:0022853", "l": "active monoatomic ion transmembrane transporter activity", "d": ["Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007464", "l": "The PRC1L4 complex binds the UXT gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73050", "l": "guanidinoacetate(in) <=> guanidinoacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.4", "l": "\"signal-recognition-particle GTPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15408", "l": "(3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) <=> [(3R)-hydroxybutanoate](n+1) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140683", "l": "histone H3K9me/H3K9me2 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a di or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53517", "l": "1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76031", "l": "2 H2O2 => O2 + 2 H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.15", "l": "\"(methyl)glyoxal oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944266", "l": "Association of procollagen type XI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10236", "l": "trans-2-coumarate + UDP-alpha-D-glucose = H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP", "d": []}, {"i": "EC:2.4.1.114", "l": "\"2-coumarate O-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42225", "l": "A + testosterone => AH2 + androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44378", "l": "a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out) => a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62681", "l": "naphtopyrone YWA1 => H(+) + H2O + norrubrofusarin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47415", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24902", "l": "3',3'-c-di-GMP + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H(+)", "d": []}, {"i": "EC:3.1.4.52", "l": "\"cyclic-guanylate-specific phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254251", "l": "ERBB4s80 binds YAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54603", "l": "2-oxoglutarate + O2 + octanoyl-CoA <=> 2-hydroxyoctanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164840", "l": "ADP and Pi bind to ATPase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.093101469280398", "identifiers": [{"i": "GO:0004532", "l": "RNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule."]}, {"i": "REACT:R-HSA-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24884", "l": "H(+) + L-glutamate + NADPH => (S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40150", "l": "eicosanoyl-CoA + H2O <=> CoA + eicosanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39361", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+) => (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43195", "l": "cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34662", "l": "C30 botryococcene + S-adenosyl-L-methionine <=> 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871266", "l": "YAP1 binds TEAD3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45770", "l": "L-alaninol + L-glutamate => gamma-L-glutamyl-L-alaninol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37975", "l": "H(+) + homogentisate + phytyl diphosphate = 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate", "d": []}, {"i": "EC:2.5.1.115", "l": "\"homogentisate phytyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110311", "l": "POLZ extends translesion synthesis (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470073", "l": "Peroxynitrite enters the bacterium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18979", "l": "a quinol + dihydroxyacetone phosphate => a quinone + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381091", "l": "IRE1 dimer autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42393", "l": "D-galactose + NAD(+) => D-galactono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63054", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54110", "l": "diphosphate + guaia-4,6-diene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983424", "l": "Budding of COPII coated vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49246", "l": "18-oxo-resolvin E1 + H(+) + NADH => NAD(+) + resolvin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54882", "l": "(3R)-3-isopropenyl-6-oxoheptanoate + H(+) => (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0005365", "l": "myo-inositol transmembrane transporter activity", "d": ["Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38901", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31974", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 <=> 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21391", "l": "H2O + L-2-aminohexano-6-lactam <=> L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36453", "l": "ADP + glycyl-L-glutamate(in) + H(+) + phosphate => ATP + glycyl-L-glutamate(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74833", "l": "UDP-alpha-D-glucuronate(in) + UDP-alpha-D-xylose(out) => UDP-alpha-D-glucuronate(out) + UDP-alpha-D-xylose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354077", "l": "Integrin alphaIIb beta3 activation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215295", "l": "USP7 deubiquitinates MDM2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74930", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + H(+) + holo-[ACP] <=> (2E)-butenoyl-[ACP] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033295", "l": "hydroxyectoine binding", "d": ["Binding to hydroxyectoine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49542", "l": "(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate => (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58550", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689000", "l": "AADAC deacetylates PHEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418925", "l": "ADORA2A,B bind Ade-Rib (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332359", "l": "Active calmodulin binds CAMK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52682", "l": "CoA + H(+) + N-acetyl-L-alpha-phenylglycine => acetyl-CoA + L-alpha-phenylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507869", "l": "Aquaporins passively transport glycerol into cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29969", "l": "2'-deoxyuridine(out) + H(+)(out) => 2'-deoxyuridine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010681", "l": "PKC phosphorylates ROBO3.1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641205", "l": "RSPO:LGR binds ZNRF3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66647", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + trichobrasilenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19258", "l": "a secondary alcohol + NADP(+) => a ketone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60058", "l": "a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+) => a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16808", "l": "2-oxoglutarate + deacetoxycephalosporin C + O2 <=> CO2 + deacetylcephalosporin C + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007539", "l": "CHEK1 phosphorylates E2F6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16700", "l": "A + H2O + quinaldate <=> AH2 + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352927", "l": "dihydroxyacetone phosphate <=> glyceraldehyde 3-phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13985", "l": "ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine", "d": []}, {"i": "EC:2.7.1.39", "l": "\"homoserine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332359", "l": "Active calmodulin binds CAMK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9648268", "l": "HTR1A binds HTR1A antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54729", "l": "acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] => malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59690", "l": "D-maltoheptaono-1,5-lactone + H2O2 => D-maltoheptaose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187575", "l": "Ubiquitination of phospho-p27/p21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46378", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65976", "l": "7-dehydrocholesterol + hnu = previtamin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60735", "l": "H2O + NADP(+) + perillyl aldehyde <=> 2 H(+) + NADPH + perillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23254", "l": "[thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate => [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839112", "l": "Phosphorylation of STAT5 by cytosolic FGFR1 fusions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008440", "l": "inositol-1,4,5-trisphosphate 3-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49532", "l": "4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O = ethylene glycol + H(+) + terephthalate", "d": []}, {"i": "EC:3.1.1.102", "l": "\"mono(ethylene terephthalate) hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247837", "l": "WNT ligands traffic to the Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.8", "l": "\"ribonuclease V\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12289", "l": "an alpha-L-fucoside + H2O => an alcohol + L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.54", "l": "\"UDP-2,3-diacylglucosamine diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203130", "l": "OLR1 binds to oxidized LDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114560", "l": "Adhesion of integrin alphaIIbbeta3 to fibrin network (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33241", "l": "aminoacetone + CO2 + NADH => L-threonine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62006", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70787", "l": "H(+)(in) + L-citrulline(in) + L-ornithine(out) = H(+)(out) + L-citrulline(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49419", "l": "ADP + alpha-D-ribose 1-phosphate <=> alpha-D-ribose 1,5-bisphosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0004467", "l": "long-chain fatty acid-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68078", "l": "a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP => a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47536", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isochenodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73956", "l": "3,4-dihydroxystyrene + H(+) + NADH => 4-ethylcatechol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5633460", "l": "MDM2 binds TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51186", "l": "H(+) + octadecanoate + sn-glycero-3-phospho-L-serine => 1-octadecanoyl-sn-glycero-3-phosphoserine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25046", "l": "(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663174", "l": "p-BMAL1:p-CLOCK,NPAS2 binds PER1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0030337", "l": "DNA polymerase processivity factor activity", "d": ["An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170978", "l": "p-FRS2:CRKL binds C3G (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61289", "l": "5-deoxy-D-ribose + ATP => 5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56990", "l": "6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51426", "l": "ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate => a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40755", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate = 1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854052", "l": "Formation of the SCF-FBXL7 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73401", "l": "D-aspartate(out) + sulfate(in) => D-aspartate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74153", "l": "CoA + H(+) + N(6)-acetyl-L-lysyl-[beta-tubulin] => acetyl-CoA + L-lysyl-[beta-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47436", "l": "(2E,7Z)-hexadecadienoyl-CoA + H2O = (3S)-hydroxy-(7Z-hexadecenoyl)-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050268", "l": "coniferyl-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44506", "l": "a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate => 4-hydroxybenzoate + an all-trans-polyprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72969", "l": "4-methyl-2-oxopentanoate(in) + 2 Na(+)(in) => 4-methyl-2-oxopentanoate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426162", "l": "SREBP1A,2 binds the HMGCR promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59598", "l": "3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4(+) => H2O + kynuramine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106339", "l": "tRNA (cytidine 32-2'-O)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + cytosine32 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylcytidine32 in tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798257", "l": "PTPRS binds NTRK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193695", "l": "IRAK interacts with TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426489", "l": "RISC binds inexactly matching target RNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380224", "l": "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018585", "l": "fluorene oxygenase activity", "d": ["Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50622", "l": "alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22685", "l": "4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 => (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27444", "l": "NAD(+) + xylitol <=> D-xylose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003838", "l": "sterol 24-C-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432295", "l": "GPVI binds Fyn and Lyn (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11630", "l": "an aldehyde + CO2 => a 2-oxocarboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48341", "l": "a medium chain fatty acid + ATP + CoA => a medium-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047761", "l": "butyrate kinase activity", "d": ["Catalysis of the reaction: ATP + butanoate = ADP + butanoyl phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806957", "l": "MET receptor dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875451", "l": "MET phosphorylates CBL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55453", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32501", "l": "(1S,3R,5S)-sabinol + H2O + NADP(+) => (1R,5R)-sabinene + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41116", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951966", "l": "EP300 acetylates RUNX3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659926", "l": "Defective SI does not hydrolyze Suc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5336443", "l": "LIN7, CASK and APBA1 bind (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43306", "l": "1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029270", "l": "Recruitment of PLCgamma to membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76034", "l": "2-oxoglutarate + O2 + thebaine <=> 3-O-demethylthebaine + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49637", "l": "H2O + methylglyoxal + O2 => H(+) + H2O2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16383", "l": "H(+) + L-xylulose + NADH => L-arabinitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788622", "l": "p-Y-STATs dimerize (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56814", "l": "4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate => 2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70796", "l": "H(+)(in) + L-lysine(out) => H(+)(out) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54737", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204364", "l": "ROBO1 binds SLIT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853429", "l": "PHLDA1 binds AURKA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701562", "l": "CD274 gene expression downstream of ALK signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879319", "l": "glucosaminyl-inositol and cysteine are ligated to desacetylmycothiol (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31599", "l": "FMNH2 + NADH + O2 + thymine = (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796626", "l": "MIB2 ubiquitinates CFLAR  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11709", "l": "H2O + IMP + NAD(+) => H(+) + NADH + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68644", "l": "(2E)-geranyl diphosphate = alpha-thujene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909721", "l": "Translocation of ISGF3 complex to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9723906", "l": "Defective TP53 does not tetramerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55593", "l": "2 (3R)-hydroxydecanoyl-[ACP] + H2O => (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25336", "l": "H(+) + L-cysteine + tRNA(Cys) => H2O + L-cysteinyl-tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74195", "l": "aspulvinone E + O2 = (5Z)-3-(3,4-dihydroxyphenyl)-5-[(3,4-dihydroxyphenyl)methylidene]-5-oxo-2,5-dihydrofuran-3-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162657", "l": "Inactivation of Myt1 kinase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19641", "l": "(E)-4-coumarate + ATP + CoA = (E)-4-coumaroyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.12", "l": "\"4-coumarate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202489", "l": "Oligomerization of Bcl10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939088", "l": "CR1 gene expression is stimulated by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204871", "l": "Interaction of Tie2 and Grb2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46394", "l": "4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758486", "l": "Unknown kinase phosphorylates 9b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53180", "l": "D-erythrose = D-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9006850", "l": "IL21 receptor JAK phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56886", "l": "2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => adenosine(32) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65357", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30648", "l": "1D-myo-inositol 3-phosphate + CTP + H(+) => CDP-1L-myo-inositol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59441", "l": "(-)-dehydrodiconiferyl alcohol + H(+) + NADPH => (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032775", "l": "YAP1 binds TEAD1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41606", "l": "1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.98", "l": "\"glucan 1,4-alpha-maltohexaosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32793", "l": "L-ectoine(out) => L-ectoine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67401", "l": "(2E,6E)-farnesyl diphosphate => allo-aromadendrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011748", "l": "IL9R binds JAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39556", "l": "3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72260", "l": "L-dopa + S-adenosyl-L-methionine => 3-O-methyl-L-dopa + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74600", "l": "AMP(out) + UDP-alpha-D-galactose(in) => AMP(in) + UDP-alpha-D-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34264", "l": "dimethylallyl diphosphate + fumigaclavine A => diphosphate + fumigaclavine C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804099", "l": "HMGB1 binds LTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42295", "l": "a fatty acyl-[ACP] + phosphate <=> an acyl phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102723", "l": "UDP-glucose:curcumin glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + curcumin = curcumin monoglucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140605", "l": "proton motive force-driven motor activity", "d": ["A motor activity driven by an electrochemical proton gradient (proton-motive force). PMF-driven motors are used by bacterial flagella."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850961", "l": "PREX2 binds PTEN and inhibits it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52395", "l": "ATP + D-erythronate <=> 4-phospho-D-erythronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14628", "l": "[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) <=> [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858252", "l": "HDLBP binds HDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029988", "l": "Dimerization of overexpressed FGFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74540", "l": "creatinine(in) => creatinine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761900", "l": "HBV X protein binds SQSTM1 oligomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710354", "l": "GSDME (1-270) binds cardiolipin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45413", "l": "H2O + prostaglandin D2-1-glycerol ester => glycerol + H(+) + prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72817", "l": "L-lysine(in) + N(omega),N(omega)-dimethyl-L-arginine(out) => L-lysine(out) + N(omega),N(omega)-dimethyl-L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191303", "l": "FDPS dimer transfers IPPP to GPP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082391", "l": "Trimerization of HSF1 in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11705", "l": "2 H(+) + N-(carboxyaminomethyl)urea => CO2 + N-(aminomethyl)urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13670", "l": "5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) => 3-hydroxy-2-methylpyridine-5-carboxylate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41647", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA <=> 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655323", "l": "Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31333", "l": "adenylyl-molybdopterin + diphosphate => ATP + H(+) + molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34585", "l": "CO2 + H2O + pentalenolactone E + succinate => 2-oxoglutarate + O2 + pentalenolactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050299", "l": "streptomycin 3''-kinase activity", "d": ["Catalysis of the reaction: ATP + streptomycin = ADP + 2 H+ + streptomycin 3''-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59940", "l": "2-methyloctadecanoyl-CoA + H2O = 2-methyloctadecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34280", "l": "di-trans,poly-cis-dolichol + NADP(+) => di-trans,cis-polyprenol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51111", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74165", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+) + octadecanoate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32934", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol <=> a cardiolipin + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004304", "l": "estrone sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622415", "l": "RIP2 binds NEMO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37563", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73718", "l": "UBF-1 Binds rDNA Promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645481", "l": "TIFA oligomerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432010", "l": "Aquaporin-1 passively transports water into cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731057", "l": "SARS-CoV-1 3a binds to caspase-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016263", "l": "glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity", "d": ["Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51274", "l": "CoA + H(+) + N-(9Z-octadecenoyl)glycine => (9Z)-octadecenoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73736", "l": "Acetylation of SL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76092", "l": "(11R)-19-hydroxycarlactone + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-19-oxocarlactone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37599", "l": "(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 = (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O", "d": []}, {"i": "EC:1.14.19.13", "l": "\"acyl-CoA 15-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106421", "l": "L-glutamate:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-glutamate(out) + H+(in) = L-glutamate(in) + H+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32419", "l": "(1S,2R,4R)-neoisodihydrocarveol + NAD(+) = (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61937", "l": "ATP + cycloheximide(in) + H2O => ADP + cycloheximide(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004074", "l": "biliverdin reductase (NAD(P)+) activity", "d": ["Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762333", "l": "ANGPTL4 binds to CDH11v (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636457", "l": "SapM dephosphorylates PI3P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164832", "l": "ATPase synthesizes ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48527", "l": "ganglioside GP1c + H2O <=> ganglioside GQ1c + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29578", "l": "L-serine(in) + Na(+)(in) <=> L-serine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40473", "l": "2-methyl-(2E)-pentadecenoyl-CoA + H2O2 => (2S)-methylpentadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672973", "l": "MAP2Ks phosphorylate MAPKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66201", "l": "O2 + pentanoyl-CoA => (2E)-pentenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64229", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050267", "l": "rubber cis-polyprenylcistransferase activity", "d": ["Catalysis of the reaction: poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865482", "l": "KMT2A (MLL) binds RUNX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170796", "l": "NPC transports GCK1:GKRP from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50792", "l": "18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = aldosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174202", "l": "Degradation of multiubiquitinated Securin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38331", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592362", "l": "Activation of proMMP7 by MMP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688838", "l": "RIPK3 binds STUB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031881", "l": "DPAn-3 resolvins translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005332", "l": "gamma-aminobutyric acid:sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52661", "l": "an L-alpha-amino acid + ATP + holo-[ACP] => AMP + an L-alpha-aminoacyl-[ACP] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34045", "l": "5''-phosphoribostamycin + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + neamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9006870", "l": "IL21 receptor STAT phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874209", "l": "CREB3L4 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654603", "l": "Activated FGFR2 binds FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50961", "l": "cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67073", "l": "a very long-chain fatty acyl-CoA + H2O => a very long-chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19748", "l": "3,3',5-triiodo-L-thyronine + A + H(+) + iodide <=> AH2 + L-thyroxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625479", "l": "SRF and ELK1 bind the FOS gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71142", "l": "acetyl-CoA + 3 AH2 + 18 H(+) + 10 malonyl-CoA + 8 NADPH <=> 3 A + 10 CO2 + 11 CoA + cordypyrone A + 8 H2O + 8 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29839", "l": "L-idonate + NADP(+) = 2-dehydro-L-idonate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15415", "l": "H2O + oxaloacetate => (2R,3R)-tartrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72290", "l": "2,2-dimethylsuccinate(out) + 3 Na(+)(out) <=> 2,2-dimethylsuccinate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445448", "l": "HHIP binds Hedgehog (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434836", "l": "Syk/Lck phosphorylate LAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190265", "l": "FGFR4 binds to FGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73479", "l": "D-histidine(in) + H(+)(in) + L-ornithine(out) = D-histidine(out) + H(+)(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72621", "l": "Ribosomal scanning  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40895", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399952", "l": "Phosphorylation of LIMK-1 by PAK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176452", "l": "Degradation of ubiquitinated SMAD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25858", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56624", "l": "2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O = 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050238", "l": "pyridoxine 5-dehydrogenase activity", "d": ["Catalysis of the reaction: pyridoxine + acceptor = isopyridoxal + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019176", "l": "dihydroneopterin monophosphate phosphatase activity", "d": ["Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183052", "l": "CBL binds to GRB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26344", "l": "L-selenocysteine + S-methyl-L-methionine <=> H(+) + L-methionine + Se-methyl-L-selenocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.7", "l": "\"N-formylmethionyl-peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14866", "l": "S-adenosyl-L-methionine + tyramine => H(+) + N-methyltyramine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69005", "l": "Cdc6 protein is phosphorylated by CDK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49980", "l": "H2O + hexanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669012", "l": "EDA binds EDAR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10887", "l": "(24R,24(1)R)-fucosterol epoxide <=> acetaldehyde + desmosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10069", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose => 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11218", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + ADP => a 2'-deoxyribonucleoside 5'-phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047047", "l": "oxaloglycolate reductase (decarboxylating) activity", "d": ["Catalysis of the reaction: glycerate + CO2 + NAD(P)+ = NAD(P)H + H+ + 2-hydroxy-3-oxosuccinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13446", "l": "(R)-pantetheine + H2O => (R)-pantothenate + cysteamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23818", "l": "4-aminobutanal + L-glutamate => 2-oxoglutarate + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36925", "l": "3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA => (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73143", "l": "CoA(out) + FAD(in) = CoA(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.12", "l": "\"N-acetylgalactosamine-4-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12602", "l": "2-oxoglutarate + L-2-aminoadipate => 2-oxoadipate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23659", "l": "2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate <=> 3-carboxy-cis,cis-muconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5678327", "l": "MIOX oxidises Ins to GlcA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.2", "l": "\"pyrimidine-nucleoside phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11049", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-organyl-2-lyso-sn-glycero-3-phospholipid => 1-O-alkyl-sn-glycero-3-phosphocholine + a 1-organyl-2-acetyl-sn-glycero-3-phospholipid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24001", "l": "a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] => a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27623", "l": "geranylgeranyl diphosphate + 7 isopentenyl diphosphate => 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050733", "l": "RS domain binding", "d": ["Binding to an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617668", "l": "HOXB3 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674140", "l": "PAQR3 binds inactive RAFs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22651", "l": "holo-[cytochrome c] <=> apo-[cytochrome c] + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015485", "l": "cholesterol binding", "d": ["Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944454", "l": "mTORC1 phosphorylates MAF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433488", "l": "Phosphorylation of SHP2 by SFKs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10528", "l": "dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.100", "l": "\"dihydrosanguinarine 10-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166538", "l": "The bound receptor dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18872", "l": "ATP + L-xylulose <=> ADP + H(+) + L-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51638", "l": "a quinol + selenate => a quinone + H2O + selenite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38834", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.576969997299727", "identifiers": [{"i": "GO:0035251", "l": "UDP-glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23068", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA = 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)", "d": []}, {"i": "EC:2.3.1.94", "l": "\"6-deoxyerythronolide-B synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70511", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867613", "l": "PICALM binds R-SNAREs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15251", "l": "1-O-galloyl-beta-D-glucose + UDP => 3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080131", "l": "hydroxyjasmonate sulfotransferase activity", "d": ["Catalysis of the reaction: a hydroxyjasmonate + 3'-phosphoadenosine-5'-phosphosulfate = a hydroxyjasmonate sulfate + adenosine-3',5'-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682026", "l": "MRN bound to shortened telomeres activates ATM (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71452", "l": "bradykinin + H2O => bradykinin(1-7) + L-Phe-L-Arg", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56929", "l": "abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130349", "l": "Generation of CLIP from lip10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36125", "l": "gibberellin A20 methyl ester + S-adenosyl-L-homocysteine => gibberellin A20 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45009", "l": "H2O + N-(octadecanoyl)-sphinganine => octadecanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25605", "l": "2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O = 2-(3-methylsulfanyl)propylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45739", "l": "(3E)-hexenoyl-CoA <=> (2E)-hexenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033905", "l": "xylan endo-1,3-beta-xylosidase activity", "d": ["Catalysis of the random hydrolysis of (1->3)-beta-D-glycosidic linkages in (1->3)-beta-D-xylans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52598", "l": "3-oxocholan-24-oyl-CoA + H(+) + NADH => lithocholoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46019", "l": "(20R)-20-hydroxypregn-4-en-3-one + NAD(+) <=> H(+) + NADH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035496", "l": "lipopolysaccharide-1,5-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,5 alpha-D-galactosyl-lipopolysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1013020", "l": "Activation of GIRK/Kir3 Channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029468", "l": "Conversion of PA into DAG by PAP-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33091", "l": "1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) = 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373705", "l": "Caspase cleavage of DCC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11354", "l": "acetyl phosphate + ADP => acetate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49553", "l": "H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] => H(+) + L-lysyl-[protein] + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68555", "l": "NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine <=> H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37441", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46793", "l": "an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43543", "l": "ATP + L-seryl-[isocitrate dehydrogenase] <=> ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33198", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012087", "l": "Autocatalytic phosphorylation of FGFR4 Y367C mutant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2514865", "l": "cGMP dissociates from CNG channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29008", "l": "H(+)(in) + Mn(2+)(in) => H(+)(out) + Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917839", "l": "apo-Transferrin dissociates from the receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389523", "l": "BTLA interacts with HVEM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357828", "l": "RIPK1 is cleaved by CASP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38587", "l": "UDP-alpha-D-glucose + vancomycin aglycone = devancoaminyl-vancomycin + UDP", "d": []}, {"i": "EC:2.4.1.310", "l": "\"vancomycin aglycone glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198714", "l": "ERK5 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57459", "l": "(E)-sinapate + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11162", "l": "L-aspartate 4-semialdehyde + L-glutamate => 2-oxoglutarate + L-2,4-diaminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34133", "l": "cannabinerolate + diphosphate => neryl diphosphate + olivetolate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018677", "l": "pentachlorophenol monooxygenase activity", "d": ["Catalysis of the reaction: pentachlorophenol + NADPH + H+ + O2 = tetrachlorohydroquinone + NADP+ + chloride."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50445", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 => prostaglandin G3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54190", "l": "acetate + L-phenylalanine => H2O + N-acetyl-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66661", "l": "ATP + beta-D-glucosylceramide(in) + H2O => ADP + beta-D-glucosylceramide(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55616", "l": "a carotenoid psi-end group = a carotenoid epsilon-end group", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981353", "l": "RASA1 stimulates RAS GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45633", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22534", "l": "(3S)-hydroxyoctanedioyl-CoA => (2E)-octenedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42385", "l": "4,4'-diaponeurosporenal + H2O + NAD(+) => 4,4'-diaponeurosporenoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3000433", "l": "SUMOylation of PML with SUMO3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814831", "l": "TBC1D20 binds RAB1:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14778", "l": "AMP + H(+) + H2O => IMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849463", "l": "PTK6 phosphorylates SFPQ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33634", "l": "ATP + CoA + octanoate <=> AMP + diphosphate + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944230", "l": "Association of procollagen type XVIII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42097", "l": "ATP + carbamoyl phosphate + H2O + tobramycin => AMP + diphosphate + H(+) + nebramycin 5' + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617825", "l": "TRAF3IB1 recruits IFT20 to the IFT B complex from the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27919", "l": "H2O + NADP(+) + propanal => 2 H(+) + NADPH + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72383", "l": "Na(+)(out) + urate(in) = Na(+)(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63676", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52884", "l": "H2O + N-phenylhydroxylamine + 2 NADP(+) = 2 H(+) + 2 NADPH + nitrobenzene", "d": []}, {"i": "EC:1.7.1.16", "l": "\"nitrobenzene nitroreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13662", "l": "H2O + N-formimidoyl-L-aspartate => N-formyl-L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001049", "l": "RNA polymerase V core binding", "d": ["Binding to RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9017817", "l": "Gamma-secretase cleaves YBX1:NOTCH3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171106", "l": "LDLR:LDL complex => LDLR + LDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2984226", "l": "PLK1 phosphorylates NEK9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71574", "l": "5-O-(L-seryl)-dTMP in DNA + H(+) <=> 5-aminoethoxy-methyl-dUMP in DNA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671702", "l": "AP1G2 binds HGS and CHMP2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9619376", "l": "CAMK1 binds calmodulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611158", "l": "Fusion of HCMV Envelope with Plasma Membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088207", "l": "Golgi lumen glycoconjugates translocate to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48346", "l": "a D-galactosylceramide + H(+) + UDP => an N-acyl-sphingoid base + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30647", "l": "1D-myo-inositol 3-phosphate + CTP + H(+) = CDP-1L-myo-inositol + diphosphate", "d": []}, {"i": "EC:2.7.7.74", "l": "\"1L-myo-inositol 1-phosphate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852331", "l": "GTSE1 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74372", "l": "a carboxylate(out) + nicotinate(in) => a carboxylate(in) + nicotinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31769", "l": "L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => 2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54046", "l": "7-epi-alpha-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46723", "l": "(3R)-hydroxyhexanoyl-CoA <=> (2E)-hexenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052807", "l": "aflatoxin reductase (coenzyme F420) activity", "d": ["Catalysis of the reaction: aflatoxin + 1,5-dihydrocoenzyme F420 = aflatoxin with reduced furanocoumarin moiety + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174124", "l": "Dephosphorylation of phospho-Cdh1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-481044", "l": "Surface deployment of platelet alpha granule membrane components (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8870466", "l": "RGGT:CHM binds RABs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67443", "l": "H2O + N(alpha)-acetyl-L-methionine <=> acetate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39854", "l": "2 a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29540", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16441", "l": "H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)", "d": []}, {"i": "EC:3.5.1.44", "l": "\"protein-glutamine glutaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45707", "l": "(E)-sinapyl alcohol + NADP(+) <=> (E)-sinapaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174070", "l": "Association of Cdh1 with the APC/C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111956", "l": "Calmodulin activates Cam-PDE 1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48426", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53227", "l": "16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106369", "l": "(deoxy)nucleoside phosphate kinase activity, GTP as phosphate donor", "d": ["Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + GTP = a 2'-deoxyribonucleoside 5'-diphosphate + GDP."]}, {"i": "RHEA:62124", "l": "a 2'-deoxyribonucleoside 5'-phosphate + GTP = a 2'-deoxyribonucleoside 5'-diphosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52707", "l": "H2O + UMP <=> D-ribose 5-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63884", "l": "H2O2 + L-tyrosine = H2O + L-dopa", "d": []}, {"i": "EC:1.11.2.6", "l": "\"L-tyrosine peroxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49085", "l": "(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] => (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52817", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37406", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080011", "l": "baruol synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = baruol. Baruol is also known as D:B-Friedo-Baccharan-5,21-dien-3-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48272", "l": "2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000048", "l": "peptidyltransferase activity", "d": ["Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). This reaction is catalyzed by a ribozyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53266", "l": "2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41405", "l": "(R)-2-methylpyrrolidine + NADP(+) => 2-methyl-1-pyrroline + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134800", "l": "STING dimerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74043", "l": "L-alanine(in) + L-methionine(out) = L-alanine(out) + L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16026", "l": "an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA => an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12268", "l": "2-oxoglutarate + putrescine = 1-pyrroline + H2O + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641147", "l": "DACT1 binds DVL2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57310", "l": "diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine => CTP + H(+) + N(5)-phospho-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-83677", "l": "C4 deamination of cytidine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38718", "l": "ATP + choline(out) + H2O <=> ADP + choline(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949687", "l": "LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47874", "l": "ganglioside GA1 + N-acetylneuraminate => ganglioside GM1 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29444", "l": "H(+)(in) + L-alanine(in) => H(+)(out) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205231", "l": "Dimerization of KIT upon SCF binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5662466", "l": "XYLB phosphorylates D-xylulose (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43261", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60198", "l": "CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391941", "l": "BLT receptors can bind LTB4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162188", "l": "MDMQ10H2 is methylated to DMQ10H2 by COQ5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399930", "l": "Activation of PAK by Rac1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448963", "l": "Interaction of MyoD:E protein with MEF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50069", "l": "ATP + glycoursodeoxycholate(in) + H2O => ADP + glycoursodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140796", "l": "histone H3R8 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H3 L-arginyl (position 8)= histone H3 L-citrullyl (position 8) + NH4+, resulting in histone H3 citrullination at position 8."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617431", "l": "Retinoic acid activates HOXA1 chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50561", "l": "acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814674", "l": "Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14435", "l": "a tRNA with a 3' CCA end + 3 diphosphate => a tRNA precursor + ATP + 2 CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29122", "l": "a ubiquinol + nitrate <=> a ubiquinone + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13464", "l": "3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2 <=> 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877158", "l": "P2X7 forms oligomeric non-selective cation channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19367", "l": "ADP + D-ribulose 1,5-bisphosphate + H(+) => ATP + D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43238", "l": "1,2-dihexadecanoyl-sn-glycerol + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14744", "l": "4-methylene-L-glutamine + H2O <=> 4-methylene-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728804", "l": "SARS-CoV-1 nsp1 binds to PPIase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36541", "l": "CoA + H(+) + N-hexadecanoylsphinganine => hexadecanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.2.13", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070405", "l": "ammonium ion binding", "d": ["Binding to ammonium ions (NH4+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868071", "l": "Clathrin recruits PIK3C2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071906", "l": "CRD domain binding", "d": ["Binding to a CRD (context dependent regulatory) domain, a domain of about 130 residues that is the most divergent region among the LEF/TCF proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59668", "l": "D-cellohexaose + O2 = D-cellohexaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42467", "l": "biphenyl-2,2',3-triol + O2 <=> 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28422", "l": "(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39151", "l": "3-oxooctadecanoyl-CoA + H(+) + NADPH = (3R)-hydroxyoctadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23465", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46713", "l": "pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46672", "l": "aldosterone + H(+) + NADPH = 5beta-dihydroaldosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70030", "l": "N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028583", "l": "Phosphorylation of YAP by LATS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54131", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45844", "l": "(3R)-hydroxyoctanoyl-CoA + NADP(+) = 3-oxooctanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63615", "l": "prunetin + UDP-alpha-D-glucuronate <=> prunetin-5-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62755", "l": "H2O + pravastatin lactone <=> (S)-2-methylbutanoate + H(+) + pravastatin diol lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62486", "l": "2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66616", "l": "Mg(2+)(in) + 2 Na(+)(out) = Mg(2+)(out) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17509", "l": "H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22223", "l": "ent-copalyl diphosphate <=> diphosphate + ent-kaur-16-ene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618479", "l": "ABCA1 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12976", "l": "AMP + ATP <=> 2 ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40048", "l": "1,2,3-trioctanoylglycerol + H2O => 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27575", "l": "(3R)-piperidine-3-carboxamide + H2O => (3R)-piperidine-3-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42411", "l": "(2R)-2-phosphoglycerate + ATP <=> (2R)-2,3-bisphosphoglycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51452", "l": "O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate = beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58632", "l": "N-tetradecanoyl-(2S)-hydroxyglycine = glyoxylate + tetradecamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12810", "l": "4 catechol + 3 O2 => 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084912", "l": "Arresten binds integrin alpha1beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41666", "l": "chelirubine + NADH => dihydrochelirubine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13773", "l": "(S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase] = (S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.64", "l": "\"(S)-stylopine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675206", "l": "PEA15 binds MAPK monomers and dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36485", "l": "(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605723", "l": "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29881", "l": "ADP + H(+) + L-arginine(in) + phosphate => ATP + H2O + L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621370", "l": "SYK autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70118", "l": "6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62798", "l": "aurasperone A + 2 H2O + NADP(+) => H(+) + NADPH + O2 + 2 rubrofusarin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975594", "l": "PLB1 hydrolyses RPALM to atROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58453", "l": "N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66240", "l": "ATP + CoA + IC-asc-C9 = AMP + diphosphate + IC-asc-C9-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15123", "l": "cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite => dithioerythritol + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176445", "l": "SMURF2 binds SMAD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9724745", "l": "PLG(20-810) binds aprotinin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070675", "l": "hypoxanthine oxidase activity", "d": ["Catalysis of the reaction: hypoxanthine + H2O + O2 = xanthine + H2O2."]}, {"i": "REACT:R-HSA-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61071", "l": "acetyl-CoA + horhammericine <=> 19-O-acetylhorhammericine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37380", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453200", "l": "SYK autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43105", "l": "AH2 + an N-acyleicosasphinganine + O2 => A + an N-acyleicosasphing-4-enine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749253", "l": "Formation of MCM2-7 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10598", "l": "ADP + H(+) + O-phospho-L-tyrosyl-[protein] => ATP + L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047134", "l": "protein-disulfide reductase (NAD(P)) activity", "d": ["Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247960", "l": "Activation of p38 MAPK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62724", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) = (+)-isomalbrancheamide C + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9639286", "l": "RRAGC,D exchanges GTP for GDP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35784", "l": "neamine + UDP-alpha-D-kanosamine => H(+) + kanamycin B + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749647", "l": "CES2 hydrolyzes ASA- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49167", "l": "a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0035198", "l": "miRNA binding", "d": ["Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707523", "l": "Hemes bind to BACH1:MAFK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008705", "l": "methionine synthase activity", "d": ["Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15622", "l": "an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065233", "l": "CS is cleaved from its proteoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008760", "l": "UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity", "d": ["Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51475", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31416", "l": "(2Z,6E)-farnesyl diphosphate => (+)-2-epi-prezizaene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38527", "l": "1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45224", "l": "(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA = (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31893", "l": "1-phenyl-1,2-propanedione + H(+) + NADPH => 2-hydroxy-1-phenyl-1-propanone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082356", "l": "HSF1-mediated gene expression (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106276", "l": "biliberdin reductase NAD+ activity", "d": ["Catalysis of the reaction: bilirubin + NAD+ = biliverdin + NADH+ H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72744", "l": "leukotriene C4(out) => leukotriene C4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159771", "l": "Furin cleaves pro-protein C to protein C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25515", "l": "(2S)-2-amino-4-deoxychorismate + L-glutamate <=> chorismate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210300", "l": "Interaction of DAP12 and TREM2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61945", "l": "24-methylenecholesterol + UDP-alpha-D-glucose => 24-methylene cholesteryl beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.652932776586212", "identifiers": [{"i": "GO:0016647", "l": "oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen."]}, {"i": "EC:1.5.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44491", "l": "3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35277", "l": "3-oxooctadecanoyl-CoA + H(+) + NADH => 3-hydroxyoctadecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033478", "l": "USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694409", "l": "Nucleotide exchange on RAB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69947", "l": "3-dehydro-6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534160", "l": "HSPG2 (perlecan) degradation by MMP13, CTSS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47221", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669158", "l": "NF2 binds PAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170159", "l": "Translocation of Cdc25 to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928614", "l": "EFNB:GRB4 binds GIT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66170", "l": "[protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate => [protein]-with a C-terminal TM segment(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10287", "l": "L-leucine <=> (3R)-beta-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46731", "l": "(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 <=> (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35556", "l": "cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40309", "l": "(2E)-decenedioyl-CoA + AH2 => A + decanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17747", "l": "beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP => N-acetyl-D-glucosamine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33002", "l": "(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26170", "l": "fumarate + H(+) + pyruvate => 3-fumarylpyruvate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805943", "l": "S100A1 binds TLR4:LY96 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218812", "l": "FYN phosphorylates PAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433451", "l": "JAK2 binds to p-KIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862700", "l": "CMKLR1 binds Resolvin E1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67104", "l": "2-oxoglutarate + fumigatonoid C + O2 = CO2 + H2O + novofumigatonin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29223", "l": "menaquinone-8 + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22434", "l": "a 3-oxoacyl-CoA + H(+) + NADH => a (3S)-3-hydroxyacyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045340", "l": "mercury ion binding", "d": ["Binding to a mercury ion (Hg)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614461", "l": "Tetramerization of procollagen VI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66020", "l": "H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen] = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69669", "l": "beta-D-glucose + luteolin => H2O + luteolin 4'-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55458", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol => ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36508", "l": "docosanoyl-CoA + H(+) + malonyl-CoA => 3-oxotetracosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46976", "l": "(S)-6-hydroxynicotine + O2 = 6-hydroxy-N-methylmyosmine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58113", "l": "1''-O-acetyl-ADP-alpha-D-ribose + H2O => acetate + ADP-D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902516", "l": "sn-glycerol 3-phosphate binding", "d": ["Binding to sn-glycerol 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30551", "l": "acetyl-CoA + beta-D-glucose = 6-O-acetyl-beta-D-glucose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10523", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose <=> 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20053", "l": "NAD(+) + ribitol = D-ribulose + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.56", "l": "\"ribitol 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187506", "l": "Translocation of p27 to the nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6813626", "l": "LEAP2 binds bacteria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68057", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O => a 3'-end 3'-phospho-ribonucleotide-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73924", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + S-adenosyl-L-methionine => griseophenone D + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16494", "l": "glycerol 1,2-cyclic phosphate + H2O => glycerol 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9706393", "l": "RHOBTB3 binds ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24167", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] <=> [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30023", "l": "L-alanine + pyridoxal 5'-phosphate = pyridoxamine 5'-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388830", "l": "PI3K binds ICOS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.12", "l": "\"acyl-lipid omega-(9-4) desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:1904315", "l": "transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "d": ["Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32380", "l": "(1R,2R,4S)-limonene-1,2-diol + NAD(+) => (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16199", "l": "acetoacetyl-CoA + H(+) + NADPH => (3S)-3-hydroxybutanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874083", "l": "p-Y397-PTK2 binds SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004471", "l": "malate dehydrogenase (decarboxylating) (NAD+) activity", "d": ["Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29153", "l": "3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out) => 3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56273", "l": "4 Fe(III)-[cytochrome cL] + H2O + methanol => 4 Fe(II)-[cytochrome cL] + formate + 5 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047245", "l": "N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-D-glucose = beta-D-glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53059", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53619", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-isoafricanol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980112", "l": "Cleavage of DNER:NOTCH1 complex releases NICD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15086", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13489", "l": "(S)-canadine + H(+) + 2 O2 = berberine + 2 H2O2", "d": []}, {"i": "EC:1.3.3.8", "l": "\"tetrahydroberberine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72632", "l": "Ca(2+)(in) + 3 Li(+)(out) => Ca(2+)(out) + 3 Li(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52864", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32580", "l": "(2E)-geranyl diphosphate => (1R,5R)-beta-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30445", "l": "2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly) => 2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378975", "l": "Follitropin is a heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47950", "l": "phosphate + thiamine => H2O + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9761027", "l": "ZEB2 binds SP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132271", "l": "Factor H displaces Bb in Cb:Bb complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106141", "l": "flavin prenyltransferase activity", "d": ["Catalysis of the reaction: dimethylallylphosphate + FMNH2 = prenylated FMNH2 + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45719", "l": "H2O + N,N,N-trimethylglycyl-CoA <=> CoA + glycine betaine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20471", "l": "D-ribose 5-phosphate + hypoxanthine => H2O + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59212", "l": "holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP = AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58468", "l": "2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2 = 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427366", "l": "Transcription of intergenic spacer of the rRNA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58749", "l": "desmethylnectriapyrone + S-adenosyl-L-methionine => H(+) + nectriapyrone + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696358", "l": "TREM,CD300 binds lipids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954056", "l": "E2F6 binds TFDP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0001875", "l": "lipopolysaccharide immune receptor activity", "d": ["Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate an innate immune response. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64525", "l": "(2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA => 2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34892", "l": "selenite(in) => selenite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19602", "l": "H(+) + NADH + O2 + orcinol => 2,3,5-trihydroxytoluene + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71822", "l": "L-thyroxine(out) <=> L-thyroxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72512", "l": "(R)-carnitine(out) + 2-oxoglutarate(in) => (R)-carnitine(in) + 2-oxoglutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693250", "l": "RHOD binds effectors at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19051", "l": "(5R)-5-phosphooxy-L-lysine + GDP + H(+) => (5R)-5-hydroxy-L-lysine + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19962", "l": "a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate => a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103009", "l": "3-chlorotoluene monooxygenase activity", "d": ["Catalysis of the reaction: H+ + 3-chlorotoluene + NADH + O2 <=> 3-chlorobenzyl alcohol + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250217", "l": "ARL2:GTP binds ARL2BP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61263", "l": "H2O + L-glutamine + O2 <=> 2-oxoglutaramate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372542", "l": "Loading of dopamine into synaptic veiscles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52727", "l": "3'-phosphoadenylyl sulfate + an aliphatic (Z)-desulfo-glucosinolate <=> a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63442", "l": "3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate => (2R)-3-phosphoglycerate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36378", "l": "ATP + carbamoyl phosphate + H2O <=> carbamoyl adenylate + diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73641", "l": "CTP(in) + ITP(out) => CTP(out) + ITP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11905", "l": "2-amino-4-hydroxypteridine + H(+) + H2O => 2,4-dihydroxypteridine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683546", "l": "FURIN binds furin inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080073", "l": "spermidine:coumaroyl CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of a coumaroyl group to a nitrogen atom on the spermidine molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.18.1", "l": "\"tyrosinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60921", "l": "2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2 => a cytidine in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877153", "l": "STARD7 binds PC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433711", "l": "Cis-homodimerization of nectins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761828", "l": "NFE2L2 binds the PGD gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39961", "l": "glycerol + H(+) + hexadecanoate => 1-hexadecanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446322", "l": "PARVA associates with Paxillin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112437", "l": "Formation of NELF complex  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44815", "l": "1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-11 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61070", "l": "19-O-acetylhorhammericine + CoA => acetyl-CoA + horhammericine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202702", "l": "CD177 binds PECAM-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5681980", "l": "ATG12 binds ATG7 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30202", "l": "2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate <=> 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32581", "l": "(1R,5R)-beta-pinene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22729", "l": "H(+) + L-seryl-tRNA(Sec) + selenophosphate => L-selenocysteinyl-tRNA(Sec) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140523", "l": "GTPase-dependent fusogenic activity", "d": ["A GTPase activity that mediates the joining two lipid bilayers to form a single membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22271", "l": "ATP + streptomycin <=> ADP + H(+) + streptomycin 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71584", "l": "L-histidine(in) + Na(+)(in) => L-histidine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68735", "l": "ganoderate DM + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hainanate A + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976817", "l": "Formation of serum amyloid P decamer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56144", "l": "a quinol + nitrate = a quinone + H2O + nitrite", "d": []}, {"i": "EC:1.7.5.1", "l": "\"nitrate reductase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71074", "l": "L-arginine(in) + L-cysteine(out) <=> L-arginine(out) + L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044508", "l": "glucagon-like peptide 1 receptor activity", "d": ["Combining with glucagon-like peptide 1 and transmitting the signal across the membrane by activating an associated G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57599", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75455", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60989", "l": "(E)-hex-2-en-1-ol + NAD(+) => (E)-hex-2-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57570", "l": "7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61229", "l": "H2O + L-histidine + O2 => 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75081", "l": "Formation of AT-AC B Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22307", "l": "a ubiquinone + keto-D-fructose <=> 5-dehydro-D-fructose + a ubiquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65113", "l": "2-oxoglutarate + aculene D + O2 => aculene C + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13653", "l": "[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose = [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose", "d": []}, {"i": "EC:2.4.1.10", "l": "\"levansucrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55767", "l": "1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O <=> 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12894", "l": "prostaglandin H2 => prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61654", "l": "2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate => 2,3-dihydroxybenzoate + ATP + holo-[aryl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705961", "l": "nsp15 cleaves viral poly(U)-RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37805", "l": "1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32860", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31862", "l": "(S)-2,3-epoxysqualene <=> glutinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72814", "l": "L-arginine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) <=> L-arginine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.14.1", "l": "\"yeast ribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26290", "l": "2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine => 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218836", "l": "PTK2beta binds alphaVbeta3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44817", "l": "1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-12 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928625", "l": "PAKs autophosphorylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811479", "l": "ING2 recruits EP300 to TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10775", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O <=> D-glucose + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43226", "l": "(24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36599", "l": "hydrogen sulfide + NAD(+) = NADH + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109862", "l": "MAP2K2 phosphorylates MAPK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47449", "l": "(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40666", "l": "L-serine <=> 2-aminoprop-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64370", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2 => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418904", "l": "A1 and A3 receptors bind adenosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41462", "l": "a 1,2-diacylglycerol + a sphingomyelin => 1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70514", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75452", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55480", "l": "ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.69", "l": "\"ent-cassadiene hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68484", "l": "(2R)-2-hydroperoxydodecanoate + H(+) = CO2 + H2O + undecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63730", "l": "candesartan-2-N-beta-D-glucuronide + UDP => candesartan + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73226", "l": "(3S)-citramalate(in) + sulfate(out) <=> (3S)-citramalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65037", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140777", "l": "protein-containing complex stabilizing activity", "d": ["A molecular function that involves direct binding to one of the subunits of a protein-containing complex, thus preventing an interaction with a factor that would promote dissociation of the complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53158", "l": "H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26473", "l": "(E)-feruloyl-CoA + 16-hydroxyhexadecanoate <=> 16-feruloyloxyhexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75374", "l": "guanosine(in) <=> guanosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694409", "l": "Nucleotide exchange on RAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66582", "l": "adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+) => 3'-phosphoadenylyl sulfate + bisphenol A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65679", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine <=> a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710959", "l": "p-STAT1 dimer binds KPNA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45265", "l": "(9Z,12Z)-octadecadienoate(out) => (9Z,12Z)-octadecadienoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20579", "l": "aminohydroquinone => 3-hydroxyaminophenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212356", "l": "Formation of CSL-NICD coactivator complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39345", "l": "(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O => (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50571", "l": "acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72722", "l": "eIF2 activation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9671145", "l": "DKC1 binds SHQ1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917730", "l": "Cargo Recognition And Sorting (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14156", "l": "17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine <=> 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72168", "l": "2 Na(+)(out) + taurohyodeoxycholate(out) => 2 Na(+)(in) + taurohyodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633460", "l": "MDM2 binds TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64252", "l": "glycine + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.54", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799246", "l": "CHEK1 phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63193", "l": "[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 => glycine betaine + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48490", "l": "all-trans-retinal--[retinol-binding protein] + H(+) + NADH => all-trans-retinol--[retinol-binding protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102469", "l": "naringenin 2-hydroxylase activity", "d": ["Catalysis of the reaction: (S)-naringenin + NADPH + O2 <=> 2-hydroxynaringenin + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51943", "l": "(1E,2S)-2-methylbutanal oxime <=> (1Z,2S)-2-methylbutanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018826", "l": "RHOT2 hydrolyzes GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28550", "l": "acetyl-CoA + anthranilate = CoA + N-acetylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58228", "l": "L-asparaginyl-[protein] + NAD(+) = H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10728", "l": "GDP-6-deoxy-alpha-D-talose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58418", "l": "(E)-4-hydroxynon-2-enal + H(+) + NADPH => (E)-4-hydroxynon-2-en-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14789", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.198", "l": "\"phosphatidylinositol N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9702818", "l": "CALCR binds erenumab (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814831", "l": "TBC1D20 binds RAB1:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008761", "l": "UDP-N-acetylglucosamine 2-epimerase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351871", "l": "Caspase-mediated cleavage of Z0-2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018786", "l": "haloalkane dehalogenase activity", "d": ["Catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40174", "l": "dodecanoyl-CoA + O2 <=> (2E)-dodecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49251", "l": "galactitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> galactitol 1-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031798", "l": "type 1 metabotropic glutamate receptor binding", "d": ["Binding to a type 1 metabotropic glutamate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73650", "l": "CTP(out) + IMP(in) <=> CTP(in) + IMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46236", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38235", "l": "(9Z)-octadecenoyl-CoA + octadecan-1-ol = 1-O-octadecyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61447", "l": "a tetracycline + H(+) + NADPH + O2 <=> an 11a-hydroxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30209", "l": "formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin] => H2O + methylamine + 2 oxidized [amicyanin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388605", "l": "POMC(138-176) binds MC2R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43209", "l": "5-(carboxymethyl)uridine(34) in tRNA + S-adenosyl-L-methionine => 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71163", "l": "H(+)(in) + L-alanine(out) + Na(+)(out) = H(+)(out) + L-alanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983707", "l": "SYK autophosphorylates at the activated BCR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102411", "l": "quercetin-3,4'-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) <=> quercetin 3,4'-O-diglucoside + UDP(3-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43222", "l": "H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49004", "l": "aurachin C + H(+) + NADPH + O2 = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672980", "l": "Dissociation of RAS:RAF complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852013", "l": "BTNL8 binds resting T cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691154", "l": "HFE binds TFRC dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3791319", "l": "NID1 degradation by MMP19 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55277", "l": "9-cis-retinol + tetradecanoyl-CoA => 9-cis-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58633", "l": "N-tetradecanoyl-(2S)-hydroxyglycine => glyoxylate + tetradecamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177920", "l": "Binding of GRB2 to GAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371591", "l": "Trimerization of cytosolic HSF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43050", "l": "keto-D-sorbose => keto-D-tagatose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684169", "l": "G6B binds PTPN6,PTPN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15499", "l": "1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine => 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034246", "l": "mitochondrial transcription factor activity", "d": ["Interacting with the mitochondrial promoter DNA to modulate transcription by the mitochondrial RNA polymerase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61432", "l": "(R)-8-oxocitronellyl enol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.123", "l": "\"7-epi-iridoid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36096", "l": "S-adenosyl-L-methionine + salicylate => methyl salicylate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19583", "l": "discadenine + H(+) + S-methyl-5'-thioadenosine => N(6)-dimethylallyladenine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65811", "l": "decanoyl-[ACP] + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> dec-9-ynoyl-[ACP] + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57856", "l": "(E)-feruloyl-CoA + 2-oxoglutarate + O2 = (E)-6-hydroxyferuloyl-CoA + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.61", "l": "\"feruloyl-CoA 6-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018874", "l": "CYP monooxygenates EPA to 18(S)-HpEPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626816", "l": "PIN1 binds p-S345-NCF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55741", "l": "H2O + oleuropein => D-glucose + oleuropein aglycone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44202", "l": "12-methyloctadecanoyl-CoA + AMP + diphosphate => 12-methyloctadecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76416", "l": "Benzene is hydroxylated to phenol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013021", "l": "GDIs block activation of RHOB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23173", "l": "ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] => ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603419", "l": "Activated NTRK3 binds SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70250", "l": "N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose <=> beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0005518", "l": "collagen binding", "d": ["Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10190", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+) => acetoacetyl-CoA + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50070", "l": "ADP + glycoursodeoxycholate(out) + H(+) + phosphate => ATP + glycoursodeoxycholate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865320", "l": "CBFB binds RUNX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932284", "l": "PKC phosphorylates NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169719", "l": "Secreted CD14 binds LPS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993802", "l": "HLCS biotinylates PC:Mn2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74342", "l": "O-3-methylbutanoyl-(R)-carnitine(in) <=> O-3-methylbutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53976", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32898", "l": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002460", "l": "P4HB binds Collagen chains (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38528", "l": "1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.350", "l": "\"ureidoglycolate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62026", "l": "campesterol + D-glucose => campesteryl 3-beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64116", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46977", "l": "(S)-6-hydroxynicotine + O2 => 6-hydroxy-N-methylmyosmine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70519", "l": "(R)-octopamine + S-adenosyl-L-methionine = (R)-synephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635839", "l": "ULK3:SUFU dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59024", "l": "H2O + trihexadecanoylglycerol = dihexadecanoylglycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41240", "l": "N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2 => N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69301", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate => benzyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45522", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit] => phycoviolobilin-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48633", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050280", "l": "sequoyitol dehydrogenase activity", "d": ["Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + NAD+ = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62083", "l": "D-glucose 6-sulfate + NADP(+) <=> 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008020", "l": "G protein-coupled photoreceptor activity", "d": ["Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34536", "l": "H(+) + hexadecanoyl-CoA + L-alanine => 1-deoxy-3-dehydrosphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162657", "l": "Inactivation of Myt1 kinase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74726", "l": "Dissociation of insulin from insulin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676254", "l": "Formation of the MLL3 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65279", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39937", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209925", "l": "DIT and MIT combine to form triiodothyronine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944225", "l": "Association of procollagen type XVII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70265", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630795", "l": "p16INK4A mutants do not bind CDK4,CDK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351229", "l": "N-acetylated spermine (cytosol)=>N-acetylated spermine (peroxisomal) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39620", "l": "(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH => (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24928", "l": "H2O + L-cystine => NH4(+) + pyruvate + S-sulfanyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43603", "l": "3-oxoeicosanoyl-[ACP] + H(+) + NADPH <=> 3R-hydroxyeicosanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351208", "l": "Spermidine  => N-acetylated spermidine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35982", "l": "dimethylallyl diphosphate + verruculogen <=> diphosphate + fumitremorgin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717396", "l": "SCN2A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68160", "l": "N-geranyl-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(8'-hydroxygeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30153", "l": "FAD + 2 H(+) + NADPH => FADH2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351341", "l": "Exocytosis of Proactivator polypeptide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36145", "l": "hexadecanoyl-CoA + NADP(+) => (2E)-hexadecenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.121", "l": "\"Lys-Lys/Arg-Xaa endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28911", "l": "H(+)(out) + L-lysine(out) = H(+)(in) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36985", "l": "3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA => (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854466", "l": "VLDLR binds RELN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59722", "l": "D-maltohexaonate + H(+) => D-maltohexaono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30696", "l": "3-aminopropanal + H2O + NAD(+) => beta-alanine + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20862", "l": "(6R)-isopiperitenone + H(+) + NADH => (1S,6R)-isopiperitenol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112727", "l": "Serine phosphorylation of STATs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0045543", "l": "gibberellin 2-beta-dioxygenase activity", "d": ["Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 2-beta-hydroxygibberellin + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679205", "l": "ULK1 phosphorylates Beclin-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614614", "l": "Cysteine is degraded to serine and H2S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013109", "l": "RHOC GEFs activate RHOC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57267", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP <=> GDP + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48887", "l": "NADP(+) + protochlorophyllide a <=> 3,8-divinyl protochlorophyllide a + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350186", "l": "CUBN binds GC:25(OH)D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448744", "l": "IL20RA binds IL20RB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44329", "l": "1-octanoylglycerol + H2O => glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654603", "l": "Activated FGFR2 binds FRS3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11786", "l": "H(+) + NADPH + NH4(+) + oxaloacetate => H2O + L-aspartate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869683", "l": "oxPL binds LBP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668404", "l": "TNFA binds TNFR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70995", "l": "L-cystine(out) + L-glutamate(in) = L-cystine(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656269", "l": "Defective CHST6 does not transfer SO4(2-) to GlcNAc residues on keratan-PG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59931", "l": "erythritol + NADP(+) <=> D-erythrose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66612", "l": "N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA = methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9640195", "l": "RRAGA,B hydrolyzes GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19843", "l": "CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33992", "l": "(2E,6E)-farnesyl diphosphate => alpha-copaene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58117", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose => 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10412", "l": "ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37803", "l": "a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667914", "l": "ALK binds ligand midkine (MDK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74436", "l": "a 1-acyl-sn-glycero-3-phosphocholine(out) + H(+)(out) => a 1-acyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33598", "l": "(4R)-hydroxysphinganine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42690", "l": "A + ergothioneine + NH4(+) + pyruvate => AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110491", "l": "DRheb is inhibited by the TSC1/2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75596", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 11-hydroxy-12,13-epoxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24518", "l": "CoA + H(+) + N(2')-acetylgentamicin C1a => acetyl-CoA + gentamicin C1a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.18", "l": "\"pancreatic ribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25240", "l": "ATP + CDP <=> ADP + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-398185", "l": "LARG binds plexin B1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022935", "l": "MECP2 binds GAD1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83677", "l": "C4 deamination of cytidine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17621", "l": "acetyl-CoA + citramalate = (3S)-citramalyl-CoA + acetate", "d": []}, {"i": "EC:2.8.3.11", "l": "\"citramalate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72357", "l": "dehydroepiandrosterone 3-sulfate(in) + glutarate(out) => dehydroepiandrosterone 3-sulfate(out) + glutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16952", "l": "myo-inositol + NAD(+) <=> H(+) + NADH + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034891", "l": "endosulfan diol dehydrogenase activity", "d": ["Catalysis of the reaction: endosulfan diol = endosulfan hydroxyether + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18417", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + ganglioside GM3 (d18:1(4E)) + H(+)", "d": []}, {"i": "EC:2.4.3.9", "l": "\"lactosylceramide alpha-2,3-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32623", "l": "L-threo-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11802", "l": "AMP + beta-nicotinamide D-ribonucleotide + 2 H(+) => H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70578", "l": "3',5'-cyclic UMP + H2O <=> H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34448", "l": "dTDP-6-deoxy-beta-L-talose + NAD(+) => dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20104", "l": "a long-chain fatty acid + ATP + L-cysteinyl-[protein] <=> AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0051540", "l": "metal cluster binding", "d": ["Binding to a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41362", "l": "H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13592", "l": "3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate <=> 3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45571", "l": "[heparosan](n) <=> [acharan](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16118", "l": "acetoacetate + ATP + CoA => acetoacetyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634442", "l": "KLF5 gene expression is enhanced by CEBPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423632", "l": "AFXBO binds DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74247", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805061", "l": "CK2 binds FACT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624954", "l": "INPP5E translocates to the primary cilium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56398", "l": "(3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+) => [(3R)-hydroxybutanoate](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982765", "l": "Growth hormone forms dimers and oligomers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901974", "l": "glycerate transmembrane transporter activity", "d": ["Enables the transfer of glycerate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36779", "l": "2-oxoglutarate + GDP-alpha-D-perosamine = GDP-4-dehydro-alpha-D-rhamnose + L-glutamate", "d": []}, {"i": "EC:2.6.1.102", "l": "\"GDP-perosamine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43969", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534378", "l": "Hv1 Mediated H+ Permeability (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45473", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707523", "l": "Hemes bind to BACH1:MAFK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.3", "l": "\"acyl-CoA 6-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32187", "l": "cholest-5-en-3-one = cholest-4-en-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693198", "l": "RHOD binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807872", "l": "Active ARF recruits coatomer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15814", "l": "1H-imidazole + acetyl-CoA => CoA + N-acetylimidazole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34480", "l": "(1R,2R,3R)-prephytoene diphosphate => 15-cis-phytoene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15838", "l": "L-glutamate + methylamine => N-methyl-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19526", "l": "(2E,6E)-farnesyl diphosphate => (1S,8aR)-delta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218804", "l": "p38 MAPK activation by VEGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18049", "l": "2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde", "d": []}, {"i": "EC:2.6.1.11", "l": "\"acetylornithine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904855", "l": "proteasome regulatory particle binding", "d": ["Binding to a proteasome regulatory particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0042285", "l": "xylosyltransferase activity", "d": ["Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40496", "l": "N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2 => N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10919", "l": "(1R,2R,3R)-prephytoene diphosphate <=> all-trans-phytoene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67454", "l": "4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+) => a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49201", "l": "D-mannose 6-phosphate + H2O + phosphoenolpyruvate => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45786", "l": "3-phenylpropanoate + NH4(+) => 2 H2O + phenylpropanonitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56459", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 12-epi-fischerindole U", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35688", "l": "NADP(+) + tetradecasphinganine => 3-oxotetradecasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686088", "l": "CASP3 cleaves GSDMD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12184", "l": "(S,S)-butane-2,3-diol + NAD(+) = (S)-acetoin + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.76", "l": "\"(S,S)-butanediol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.5", "l": "\"pyridoxal 5'-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112395", "l": "Abortive termination of elongation after arrest (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16003", "l": "IMP + methylamine => H(+) + H2O + N(6)-methyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14896", "l": "D-ornithine <=> (2R,4S)-2,4-diaminopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22592", "l": "(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (9S,13S,15Z)-12-oxophyto-10-15-dienoate", "d": []}, {"i": "EC:5.3.99.6", "l": "\"allene-oxide cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75295", "l": "chloride(in) + sulfate(out) = chloride(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633241", "l": "Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674018", "l": "BRAP binds RAS:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14781", "l": "ATP + CoA + heptanedioate = 6-carboxyhexanoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.14", "l": "\"6-carboxyhexanoate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56453", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole => 12-epi-hapalindole U", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45820", "l": "mesaconate + succinyl-CoA = 2-methylfumaryl-CoA + succinate", "d": []}, {"i": "EC:2.8.3.26", "l": "\"succinyl-CoA:mesaconate CoA transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65407", "l": "butan-1-ol + hexanoyl-CoA <=> butyl hexanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015120", "l": "phosphoglycerate transmembrane transporter activity", "d": ["Enables the transfer of phosphoglycerates from one side of a membrane to the other. Phosphoglycerates are important intermediates in glycolysis and 3-phosphoglycerate is a precursor in serine biosynthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33806", "l": "H2O + L-histidinal + NAD(+) <=> 2 H(+) + L-histidine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71067", "l": "L-arginine(in) + L-phenylalanine(out) = L-arginine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42298", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP] => a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59070", "l": "deoxyspectinabilin + S-adenosyl-L-homocysteine => demethyldeoxyspectinabilin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50321", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10360", "l": "3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl)propanoate + H(+)", "d": []}, {"i": "EC:3.1.1.35", "l": "\"dihydrocoumarin hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53923", "l": "ATP + L-threonyl-[Fas-activated protein] <=> ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730841", "l": "Phosphorylation and activation of VAV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12186", "l": "(S)-acetoin + H(+) + NADH => (S,S)-butane-2,3-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27834", "l": "a menaquinone + succinate = a menaquinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71783", "l": "MDH2 reduces OA to MAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110239", "l": "MPG glycosylase mediated recognition and binding of ethenoadenine  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58082", "l": "docosanoate + glycerol + H(+) => 1-docosanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22947", "l": "3beta-hydroxy-5beta-pregnane-20-one + NADP(+) <=> 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29829", "l": "Mg(2+)(out) => Mg(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788999", "l": "HV1-mediated H+ transfer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.56", "l": "\"lipopolysaccharide N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33411", "l": "(S)-malyl N-acetyl-alpha-D-glucosaminide + H2O = (S)-malyl alpha-D-glucosaminide + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700701", "l": "T-type VDCC bind T-type VDCC blockers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40997", "l": "4-hydroxybenzaldehyde + acetyl-CoA => 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63032", "l": "a fatty acylamide + H2O = a fatty acid + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9681375", "l": "KIT binds ripretinib (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60320", "l": "N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61538", "l": "ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29592", "l": "2-hydroxyethane-1-sulfonate + NADP(+) => H(+) + NADPH + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22319", "l": "13-hydroxydocosanoate + UDP-alpha-D-glucose <=> 13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30716", "l": "(2E)-geraniol => (S)-linalool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202692", "l": "PIP3 binds to RhoA and activates it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44065", "l": "hexadecanoyl-CoA + octan-1-ol => CoA + octyl hexadecanoyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004610", "l": "phosphoacetylglucosamine mutase activity", "d": ["Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18162", "l": "acetyl-CoA + tetradecanoyl-CoA => 3-oxohexadecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004912", "l": "interleukin-3 receptor activity", "d": ["Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "59.13886066818997", "identifiers": [{"i": "GO:0016818", "l": "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides", "d": ["Catalysis of the hydrolysis of any acid anhydride which contains phosphorus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604712", "l": "Initial activation of proMMP7 by trypsin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626681", "l": "Recruitment of transition zone proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008736", "l": "L-fucose isomerase activity", "d": ["Catalysis of the reaction: L-fucose = L-fuculose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607736", "l": "MALT1 oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35089", "l": "D-glucosamine + N-acetyl-D-glucosamine 6-phosphate => H2O + N'-monoacetylchitobiose-6'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10741", "l": "a secondary alcohol + NAD(+) => a ketone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63647", "l": "GDP-beta-L-fucose + L-seryl-[protein] <=> 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0005534", "l": "galactose binding", "d": ["Binding to aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48452", "l": "ganglioside GA2 (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611852", "l": "ADRB3 bind ADR,NAd (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434700", "l": "STIM1 activation of CRAC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61789", "l": "ATP + holo-[peptidyl-carrier protein] + L-tryptophan => AMP + diphosphate + L-tryptophyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49961", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 => 5,10-dihydrophenazine + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13237", "l": "D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate", "d": []}, {"i": "EC:2.6.1.16", "l": "\"glutamine--fructose-6-phosphate transaminase (isomerizing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19977", "l": "3'-phosphoadenylyl sulfate + L-tyrosine methyl ester = adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate", "d": []}, {"i": "EC:2.8.2.9", "l": "\"tyrosine-ester sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607043", "l": "factor VIIIa associates with cell membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33471", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202717", "l": "Heterodimerization of CEACAMs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029471", "l": "Hydrolysis of PC to PA by PLD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607746", "l": "PKC-delta is activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0045142", "l": "triplex DNA binding", "d": ["Binding to a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34902", "l": "malonyl-CoA + S-adenosyl-L-methionine <=> malonyl-CoA methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60127", "l": "pre-sodorifen diphosphate <=> diphosphate + sodorifen", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27562", "l": "(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211193", "l": "Homodimerization  of DFF40 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134953", "l": "DHX36 or DHX9 binds MyD88 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66108", "l": "2-oxobutanoate + L-cysteine = (2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033870", "l": "thiol sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + an S-alkyl thiosulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621371", "l": "CLEC4C binds HIV and HCV glycoproteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51753", "l": "a 2-acylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4-prenylphloroglucinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65833", "l": "AH2 + ATP + 2 Co(II)-[dimethylamine-specific corrinoid protein] + H2O => A + ADP + 2 Co(I)-[dimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28505", "l": "NAD(+) + S-(hydroxymethyl)mycothiol <=> H(+) + NADH + S-formylmycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190141", "l": "ALAD binds to Pb2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938815", "l": "RNF152 polyubiquitinates RRAGA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68202", "l": "1,2-dihexanoyl-3-hexadecanoylglycerol + CoA => 1,2-dihexanoylglycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42041", "l": "ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose => gangliosideFuc-GM1 (d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39841", "l": "a triacyl-sn-glycerol + CoA => a 2,3-diacyl-sn-glycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191656", "l": "Closure of gap junction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25870", "l": "3-acetamidopropanal + H2O2 + N(1)-acetylspermidine => H2O + N(1),N(12)-diacetylspermine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69288", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate = sulfate + sulforaphane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021948", "l": "GPRIN1 gene expression is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007646", "l": "CBX5 gene expression is inhibited by E2F6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40891", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12305", "l": "(S)-2-amino-6-oxohexanoate + H2O + NADP(+) => 2 H(+) + L-2-aminoadipate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16032", "l": "3-guanidinopropanoate + H2O <=> beta-alanine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450422", "l": "KSRP recruits RNA degradation activities (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28386", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59069", "l": "demethyldeoxyspectinabilin + S-adenosyl-L-methionine => deoxyspectinabilin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67234", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + H(+) + NADH => (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42035", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983158", "l": "Trimming of peptides in ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43650", "l": "3-oxooctadecanoyl-[ACP] + CO2 + CoA => H(+) + hexadecanoyl-CoA + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53307", "l": "AH2 + 2 ATP + 2 cob(II)alamin <=> A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621367", "l": "CLEC4A binds HIV and HCV glycoproteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173636", "l": "Formation of classic pathway C5 convertase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432946", "l": "PARVB/Affixin interacts with alpha PIX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37551", "l": "3-dehydro-D-glucose 6-phosphate + L-glutamate = 2-oxoglutarate + D-kanosamine 6-phosphate", "d": []}, {"i": "EC:2.6.1.104", "l": "\"3-dehydro-glucose-6-phosphate--glutamate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352945", "l": "fructose 6-phosphate + ATP => fructose 1,6-bisphosphate + ADP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31807", "l": "(2E,6E)-farnesyl diphosphate = alpha-guaiene + diphosphate", "d": []}, {"i": "EC:4.2.3.87", "l": "\"alpha-guaiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18045", "l": "6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O = alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)", "d": []}, {"i": "EC:3.1.4.51", "l": "\"glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210646", "l": "Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16929", "l": "2 benzoyl-CoA + L-ornithine = 2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine", "d": []}, {"i": "EC:2.3.1.127", "l": "\"ornithine N-benzoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13506", "l": "choline + O2 => betaine aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33146", "l": "galactitol(in) <=> galactitol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2327733", "l": "FN1 binds Collagen types I-V, VII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43091", "l": "5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine <=> 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682695", "l": "nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432010", "l": "Aquaporin-1 passively transports water into cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749505", "l": "LRRC14 binds IKBKB and CHUK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.12.1.-", "l": "\"Acting on sulfur-sulfur bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23039", "l": "2 inosine + O2 <=> 2 5'-dehydroinosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40834", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73610", "l": "CTP(out) + dCTP(in) <=> CTP(in) + dCTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.15", "l": "\"cathepsin L\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9646468", "l": "mTORC1 binds RHEB:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68073", "l": "Delta(2)-thiazoline-2-carboxylate + 2 H(+) + NADPH => L-thiazolidine-2-carboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11115", "l": "H2O + isochorismate <=> (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15789", "l": "L-xylose + NADP(+) = H(+) + L-xylono-1,4-lactone + NADPH", "d": []}, {"i": "EC:1.1.1.113", "l": "\"L-xylose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871266", "l": "YAP1 binds TEAD3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36775", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.309", "l": "\"UDP-Gal:alpha-L-Fuc-1,2-beta-Gal-1,3-alpha-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41878", "l": "(2E)-dodecenoyl-[ACP] + H2O => (3R)-hydroxydodecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30065", "l": "H(+) + menaquinol-8 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-8 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453200", "l": "SYK autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74243", "l": "H2O + L-alanyl-tRNA(Pro) = H(+) + L-alanine + tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28521", "l": "D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O <=> D-glycero-beta-D-manno-heptose 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30383", "l": "(2E,6E)-farnesyl diphosphate = (-)-7-epi-alpha-selinene + diphosphate", "d": []}, {"i": "EC:4.2.3.86", "l": "\"7-epi-alpha-selinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40445", "l": "6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+) => 6-deoxy-6-sulfo-D-fructose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46330", "l": "3-phenylpyruvate + NH4(+) => L-threo-3-phenylserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156678", "l": "Activation of Cdc25C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11629", "l": "a 2-oxocarboxylate + H(+) => an aldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70298", "l": "2-oxoglutarate + 3-sulfino-L-alanine <=> 3-sulfinopyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64905", "l": "GTP + 2 H2O => GMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62165", "l": "beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O => D-glucosamine + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247843", "l": "secretion of WNT ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73096", "l": "AMP(out) + CoA(in) => AMP(in) + CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35424", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0097001", "l": "ceramide binding", "d": ["Binding to a ceramide, a class of lipids composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69749", "l": "(indol-3-yl)acetyl-CoA + succinate => (indol-3-yl)acetate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31902", "l": "indole + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14315", "l": "1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine => 2-iodophenol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74928", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + H(+) + holo-[ACP] => (2E)-butenoyl-[ACP] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74263", "l": "n H(+)(out) + spermine(in) = n H(+)(in) + spermine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28732", "l": "H(+)(out) + L-leucine(in) => H(+)(in) + L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23816", "l": "2-oxoglutarate + putrescine = 4-aminobutanal + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112155", "l": "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59208", "l": "ATP + H(+) + octadecanoate = diphosphate + octadecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53311", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41684", "l": "1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O = 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507870", "l": "Aquaporins passively transport water out of cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381109", "l": "IRE1 binds IRE1 forming dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046175", "l": "Further sulfation on galactose residues produces KSPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25676", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050124", "l": "N-acylneuraminate-9-phosphatase activity", "d": ["Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36126", "l": "gibberellin A20 + S-adenosyl-L-methionine <=> gibberellin A20 methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8960973", "l": "RLBP1:11cRAL dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73199", "l": "maleate(in) + sulfate(out) = maleate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12153", "l": "(3R,4S,5S,6R)-pentachlorocyclohexene => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52544", "l": "D-erythronate + NAD(+) = 2-dehydro-D-erythronate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.410", "l": "\"D-erythronate 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32491", "l": "alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.113", "l": "\"alpha-humulene 10-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42369", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61651", "l": "ATP + holo-[non-ribosomal peptide synthase] + salicylate <=> AMP + diphosphate + salicyl-[non-ribosomal peptide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2468040", "l": "Cohesin binds PDS5 and WAPAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45914", "l": "a 4,5-saturated-(3E)-enoyl-CoA + NADP(+) => a (2E,4E)-dienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607747", "l": "TRAF6 binds MALT1 oligomers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11278", "l": "4 benzosemiquinone + 2 H2O => 4 hydroquinone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093342", "l": "SDC2 multimerises (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848316", "l": "IL36 binds IL1RL2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21661", "l": "benzaldehyde + H2O + NADP(+) => benzoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.-.-", "l": "\"Transferring alkyl or aryl groups, other than methyl groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44540", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852337", "l": "GTSE1 binds TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35198", "l": "L-quinate(in) <=> L-quinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372819", "l": "PCK2 phosphorylates OA to yield PEP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090587", "l": "protein-phosphocysteine-glucosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucosamine (out) = protein cysteine + glucosamine-6-phosphate (in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51675", "l": "glyoxal + H2O <=> glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21716", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O", "d": []}, {"i": "EC:1.14.16.6", "l": "\"mandelate 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74261", "l": "H(+) + L-homoserine + tRNA(Lys) => H2O + L-homoseryl-tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451283", "l": "kainate receptor binds glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61971", "l": "a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13349", "l": "jasmonate + S-adenosyl-L-methionine = methyl (-)-jasmonate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.141", "l": "\"jasmonate O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042959", "l": "alkanesulfonate transmembrane transporter activity", "d": ["Enables the directed movement of alkanesulfonate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010898", "l": "ROBO2 binds SLIT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640862", "l": "Tankyrase binds AXIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015322", "l": "secondary active oligopeptide transmembrane transporter activity", "d": ["Enables the transfer of an oligopeptide or oligopeptides from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140315", "l": "iron ion sequestering activity", "d": ["Binding to an iron ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60961", "l": "18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose => (9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071443", "l": "tDNA binding", "d": ["Binding to DNA sequences encoding transfer RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15545", "l": "(3S)-citramalate = acetate + pyruvate", "d": []}, {"i": "EC:4.1.3.22", "l": "\"citramalate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63550", "l": "angiotensin-(1-7) + L-phenylalanyl-L-histidine => angiotensin-(1-9) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163625", "l": "Glucagon binds to Glucagon receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852200", "l": "Inactivation of LCK by PTPN22 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018711", "l": "benzoyl acetate-CoA thiolase activity", "d": ["Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24052", "l": "a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.5.5.1", "l": "\"electron-transferring-flavoprotein dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19967", "l": "acrylate + dimethyl sulfide + H(+) => S,S-dimethyl-beta-propiothetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106364", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity", "d": ["4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]."]}, {"i": "RHEA:20361", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59745", "l": "(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] => CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54276", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 = (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797293", "l": "Expression of IL18, ALOX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084912", "l": "Arresten binds integrin alpha1beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36719", "l": "hexacosenoyl-CoA + sphinganine = CoA + H(+) + N-hexacosenoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46437", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114354", "l": "SMAC binds XIAP:Caspase-7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73527", "l": "TDP(out) + UTP(in) = TDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.594043123901756", "identifiers": [{"i": "GO:0030594", "l": "neurotransmitter receptor activity", "d": ["Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22547", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O <=> a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013435", "l": "RHOD auto-activates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204798", "l": "Interaction of Tie2 and p85 of PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73051", "l": "hydrogencarbonate(in) + taurocholate(out) = hydrogencarbonate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58054", "l": "(2-acetamidoethyl)phosphonate + CoA + H(+) => (2-aminoethyl)phosphonate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938887", "l": "PML binds RUNX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41048", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68490", "l": "CO2 + H2O + tridecanal => (2R)-2-hydroperoxytetradecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33547", "l": "H2O + lanosteryl hexadecanoate = H(+) + hexadecanoate + lanosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852324", "l": "GTSE1 binds PLK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72858", "l": "ADP(out) + dADP(in) <=> ADP(in) + dADP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1006143", "l": "CD46 binds C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27356", "l": "4'-demethylrebeccamycin + S-adenosyl-L-methionine <=> H(+) + rebeccamycin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11167", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29723", "l": "glyoxylate(in) = glyoxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36328", "l": "ADP + dimethylallyl diphosphate => diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37681", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029151", "l": "JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043723", "l": "2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity", "d": ["Catalysis of the reaction: 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonia."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635839", "l": "ULK3:SUFU dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5444511", "l": "Formation of MSH2:MSH3 Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209331", "l": "Formation of the 'scaffold complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417908", "l": "P2RY1 binds ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111238", "l": "Formation of ADAR2  homodimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061759", "l": "alpha-ketoglutarate reductase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + reduced acceptor = (S)-2-hydroxyglutarate + acceptor."]}, {"i": "RHEA:21254", "l": "2-oxoglutarate + AH2 => (S)-2-hydroxyglutarate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51560", "l": "(S)-bulbocapnine + S-adenosyl-L-methionine = (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2574845", "l": "AJUBA binds centrosome-associated AURKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433456", "l": "Recruitment of STATs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865454", "l": "CBFB binds RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211874", "l": "CYP2S1 4-hydroxylates atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19931", "l": "[(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP => [(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49051", "l": "25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39560", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA => (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858346", "l": "AMHR2 binds AMH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009024", "l": "tagatose-6-phosphate kinase activity", "d": ["Catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444661", "l": "HCAR2 binds HCAR2 ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103010", "l": "gibberellin A53,2-oxoglutarate:oxygen oxidoreductase activity (GA97-forming)", "d": ["Catalysis of the reaction: gibberellin A53 + 2-oxoglutarate + O2 = gibberellin A97 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072550", "l": "triferuloylspermidine meta-hydroxylase activity", "d": ["Catalysis of the reaction: triferuloyl spermidine + NADPH + O2 = diferuloyl mono-(hydroxyferuloyl) spermidine + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73297", "l": "7,8-dihydroxy-4'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 4',7,8-trihydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936745", "l": "deacetylation of O-acetylserine and sulfhydrylation using CysK2 (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534096", "l": "METAP1/2 demethylates GNAT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63322", "l": "a glycerophospholipid(out) + ADP + H(+) + phosphate => a glycerophospholipid(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42256", "l": "H(+) + hexanoyl-CoA + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935731", "l": "ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15968", "l": "1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23934", "l": "an N-acyl-D-mannosamine 6-phosphate => an N-acyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41682", "l": "a 2-all-trans-polyprenylphenol + CO2 => a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804100", "l": "HMGB1 binds LPS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679044", "l": "FKBP1A binds sirolimus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033704", "l": "3beta-hydroxy-5alpha-steroid dehydrogenase activity", "d": ["Catalysis of the reaction: 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ = 5alpha-pregnane-3,20-dione + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709883", "l": "BIL:ALB scavenges O2.- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.32", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018734", "l": "butyrolactone hydrolase activity", "d": ["Catalysis of the reaction: butyrolactone + H2O = 4-hydroxybutanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793901", "l": "Expression of DLL3 in paraxial mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2219524", "l": "PDPK1 binds PIP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209960", "l": "Diiodinated tyrosine can be deiodinated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013147", "l": "RAC1 GDIs block activation of RAC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167427", "l": "Opioid dissociates from MOR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-481007", "l": "Exocytosis of platelet alpha granule contents (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646383", "l": "Dynein motors transport misfolded proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190256", "l": "FGFR1c binds to FGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008587", "l": "IL37, IL37(?-218) binds IL18BP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6802973", "l": "PLK3 phosphorylates CDC25C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607751", "l": "TRAF6 oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20680", "l": "alizarin + UDP-alpha-D-glucose <=> 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75956", "l": "2-oxoglutarate + O2 + thebaine => CO2 + formaldehyde + oripavine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31025", "l": "dammara-20,24-diene => squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844612", "l": "PYCARD recruits procaspase-1 via CARD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938108", "l": "SERPINB13 binds cathepsin L (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047101", "l": "2-oxoisovalerate dehydrogenase (acylating) activity", "d": ["Catalysis of the reaction: NAD+ + CoA + 2-keto-isovalerate = NADH + CO2 + isobutyryl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10563", "l": "4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O <=> 2,5-dioxopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665524", "l": "ATP translocates from cytosol to extracellular space (stimuated by C3AR1:C3a) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67261", "l": "(E)-hept-2-enal + H2O + NAD(+) => (E)-hept-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62214", "l": "gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70346", "l": "chloride + L-tyrosine + NADP(+) <=> 3-chloro-L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399711", "l": "Activation of Ca impermeable AMPA receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31385", "l": "lupeol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106100", "l": "beta-pinacene synthase activity", "d": ["Catalysis of the cyclization of geranylgeranyl pyrophosphate (GGPP) to yield the monocyclic diterpene beta-pinacene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68972", "l": "A + sn-glycerol 3-phosphate = AH2 + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.174", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65462", "l": "CoA + hexyl acetate => acetyl-CoA + hexan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694427", "l": "MIA3 binds procollagen VII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10950", "l": "ADP + D-glucosamine 6-phosphate + H(+) => ATP + D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186785", "l": "PDGF-AA clevage by Furin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39743", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850797", "l": "SPINK6 binds KLK13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48867", "l": "2-methylpropan-1-amine + FADH2 + O2 <=> FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873917", "l": "Translocation of STAT1 dimer to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389961", "l": "ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445700", "l": "Myosin Binds ATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28480", "l": "galactarate(out) + H(+)(out) => galactarate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198298", "l": "AKT translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24151", "l": "D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791235", "l": "GADD45A binds AURKA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351341", "l": "Exocytosis of Proactivator polypeptide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209944", "l": "25(OH)D binds GC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66107", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209107", "l": "Further phosphorylation of APC by DCO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48620", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047969", "l": "glyoxylate oxidase activity", "d": ["Catalysis of the reaction: glyoxylate + H2O + O2 = H2O2 + H+ + oxalate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.23", "l": "\"matrilysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52030", "l": "a jasmonate + an L-alpha-amino acid => a jasmonyl-L-amino acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16364", "l": "2-acetolactate <=> 3-hydroxy-3-methyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12208", "l": "4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)", "d": []}, {"i": "EC:3.1.1.56", "l": "\"methylumbelliferyl-acetate deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018479", "l": "benzaldehyde dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165680", "l": "Formation of active mTORC1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68179", "l": "2-oxoglutarate + N-geranyl-L-glutamate + O2 <=> CO2 + dainate A + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050156", "l": "ornithine N-benzoyltransferase activity", "d": ["Catalysis of the reaction: L-ornithine + 2 benzoyl-CoA = N(2),N(5)-dibenzoyl-L-ornithine + 2 CoA + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.116", "l": "\"SpoIVB peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30319", "l": "H(+) + NADH + O2 + theobromine = 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30176", "l": "15-cis-phytoene + 2 plastoquinone-9 => 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72375", "l": "hydrogencarbonate(out) + iodide(in) = hydrogencarbonate(in) + iodide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451310", "l": "Activation of Edited Kainate receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51281", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69165", "l": "H2O + N-(4-aminobutyl)-3-aminopropanal + NAD(+) => 2 H(+) + N-(2-carboxyethyl)putrescine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11490", "l": "an all-trans-retinyl ester + CoA => all-trans-retinol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046428", "l": "1,4-dihydroxy-2-naphthoate octaprenyltransferase activity", "d": ["Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + polyprenylpyrophosphate = dimethylmenaquinone + diphosphate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437192", "l": "PDPK1 binds PRKCZ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.461014234140904", "identifiers": [{"i": "GO:0003774", "l": "cytoskeletal motor activity", "d": ["Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force)."]}, {"i": "REACT:R-HSA-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700701", "l": "T-type VDCC bind T-type VDCC blockers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29186", "l": "menaquinol-8 + 2 O2 <=> 2 H(+) + menaquinone-8 + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16225", "l": "1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate", "d": []}, {"i": "EC:3.5.2.12", "l": "\"6-aminohexanoate-cyclic-dimer hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102197", "l": "vinylacetate caboxylester hydrolase activity", "d": ["Catalysis of the reaction: but-3-enoate + H2O <=> allyl alcohol + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800793", "l": "PIDD1 translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797090", "l": "CCNK binds CDK12 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18925", "l": "L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.20", "l": "\"glucuronolactone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373705", "l": "Caspase cleavage of DCC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64578", "l": "2 Fe(II)-[cytochrome b5] + H(+) + NADP(+) => 2 Fe(III)-[cytochrome b5] + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65093", "l": "asperaculane G + O2 + reduced [NADPH--hemoprotein reductase] => aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60470", "l": "3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => 3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16905", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704655", "l": "SARS-CoV-1 E binds BCL2L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428918", "l": "Dissociation of the TP:G13 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10911", "l": "3'-phosphoadenylyl sulfate + glycolithocholate <=> adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420243", "l": "GHRH receptor binds GHRH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418866", "l": "PITPalpha binds DCC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.510429476229447", "identifiers": [{"i": "GO:0000981", "l": "DNA-binding transcription factor activity, RNA polymerase II-specific", "d": ["A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58167", "l": "(2E,6E)-farnesyl diphosphate + 2 H2O <=> 7-epi-ent-eudesmane-5,11-diol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800380", "l": "PTPRD binds IL1RAP-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71852", "l": "glycocholate(out) => glycocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75781", "l": "(10S)-hydroxy-(6Z,12Z,15Z)-octadecatrienoate => (6Z,9Z,12Z,15Z)-octadecatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654163", "l": "Activated FGFR4 binds PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53201", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73186", "l": "ADP(in) + FAD(out) <=> ADP(out) + FAD(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71530", "l": "thymine(out) <=> thymine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046547", "l": "trans-aconitate 3-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000773", "l": "phosphatidyl-N-methylethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31485", "l": "H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP => soyasapogenol E + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18878", "l": "myo-inositol + S-adenosyl-L-methionine => 1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35960", "l": "H(+) + NADPH + O2 + tryprostatin B => demethoxyfumitremorgin C + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692749", "l": "CDC14A,B bind MAPK6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381091", "l": "IRE1 dimer autophosphorylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73591", "l": "CTP(out) + dUTP(in) = CTP(in) + dUTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12037", "l": "(S)-3-(imidazol-5-yl)lactate + NAD(+) => 3-(imidazol-5-yl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25204", "l": "D-ribulose 5-phosphate + formaldehyde <=> D-arabino-hex-3-ulose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937814", "l": "RUNX3 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102300", "l": "linoleate 9R-lipoxygenase activity", "d": ["Catalysis of the reaction: linoleate + O2 = 9(R)-HPODE."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38456", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41356", "l": "bacteriochlorophyll a + 3 NADP(+) = geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH", "d": []}, {"i": "EC:1.3.1.111", "l": "\"geranylgeranyl-bacteriochlorophyllide a reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30945", "l": "(2E)-octenoyl-CoA + FADH2 => FAD + H(+) + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102867", "l": "molybdenum cofactor sulfurtransferase activity", "d": ["Catalysis of the reaction: 2 H+ + MoO2-molybdopterin cofactor(2-) + L-cysteine <=> thio-molybdenum cofactor + L-alanine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31372", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine => (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102150", "l": "3-oxo-myristoyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: 3-oxotetradecanoyl-CoA + H2O <=> 3-oxo-myristate + coenzyme A + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804955", "l": "ATM phosphorylates MDM2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667563", "l": "AVPR2 bind desmopressin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27407", "l": "a ubiquinol + acetate + CO2 => a ubiquinone + H2O + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69036", "l": "5beta-androstane-3,17-dione + H(+) + NADPH = 3beta-hydroxy-5beta-androstane-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.14", "l": "\"N-acyl-aliphatic-L-amino acid amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111879", "l": "PIP2 hydrolysis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382058", "l": "Nck binds to the active PDGF receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380157", "l": "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004298", "l": "threonine-type endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile."]}, {"i": "EC:3.4.25.-", "l": "\"Threonine endopeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39956", "l": "(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13048", "l": "ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.94", "l": "\"glycerol-3-phosphate dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0051400", "l": "BH domain binding", "d": ["Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14277", "l": "(S)-lactaldehyde + H2O + NAD(+) = (S)-lactate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.22", "l": "\"lactaldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35691", "l": "(2S)-versicolorone + NADP(+) = 1'-hydroxyversicolorone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450187", "l": "TAK1 is activated within the TAK1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12590", "l": "ganglioside GM2 (d18:1(4E)) + H(+) + UDP => ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983285", "l": "RAD51B binds RAD51C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44045", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53680", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426489", "l": "RISC binds inexactly matching target RNAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53498", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate => 1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71848", "l": "glycoursodeoxycholate(out) => glycoursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.4.1.-", "l": "\"Forming carbon-carbon bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62308", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) = (+)-malbrancheamide B + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65719", "l": "2-oxoglutarate + a primary linear alkyl sulfate ester + O2 <=> an aldehyde + CO2 + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24562", "l": "CoA + O-acetyl-L-serine => acetyl-CoA + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5138459", "l": "WNT5A:FZD4 is endocytosed (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19747", "l": "AH2 + L-thyroxine => 3,3',5-triiodo-L-thyronine + A + H(+) + iodide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847534", "l": "RAB43 hydrolyses GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49828", "l": "(5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52044", "l": "mogrol + UDP-alpha-D-glucose = H(+) + mogroside IE + UDP", "d": []}, {"i": "EC:2.4.1.350", "l": "\"mogroside IE synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29821", "l": "ADP + H(+) + L-isoleucine(in) + phosphate => ATP + H2O + L-isoleucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44823", "l": "1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-13 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14804", "l": "(2R)-3-phosphoglycerate + ATP <=> (2R)-3-phospho-glyceroyl phosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390597", "l": "Release Of ADP From Myosin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52308", "l": "2-hydroxyglutarate + NADP(+) = 2-oxoglutarate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77589", "l": "Recognition of AAUAAA sequence by CPSF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60982", "l": "12-oxododecanoate + H(+) + NADH => 12-hydroxydodecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.79", "l": "\"arogenate dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9644926", "l": "Transcription of DDIT3 (CHOP, GADD153) in response to amino acid deficiency (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354060", "l": "Translocation of RIAM to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004621", "l": "glycosylphosphatidylinositol phospholipase D activity", "d": ["Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266303", "l": "Spherical HDL binds C and E apolipoproteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617879", "l": "HOXA4 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187617", "l": "argininosuccinate <=> fumarate + arginine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18627", "l": "D-galactono-1,5-lactone + H(+) + NADPH => D-galactose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022073", "l": "Procollagen triple helix formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702849", "l": "CALCR binds gepants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112755", "l": "SOCS3 binds IL6ST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802165", "l": "TP53 binds the PLK3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391942", "l": "IP receptor can bind prostacyclin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65403", "l": "butan-1-ol + butanoyl-CoA <=> butyl butanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507875", "l": "Aquaporins passively transport urea into cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48478", "l": "ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate => ganglioside GT1a (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11457", "l": "N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371518", "l": "SIRT1 binds to HSF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66733", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in) => ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33259", "l": "4-aminoimidazole + H(+) + 2 H2O = N-formimidoylglycine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912627", "l": "CBL ubiquitinates PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13457", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H(+) = (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2", "d": []}, {"i": "EC:1.2.4.4", "l": "\"3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103072", "l": "straight chain (R)-2-hydroxy fatty acyl-CoA lyase activity", "d": ["Catalysis of the reaction: a (R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acyl CoA = formyl-CoA + an odd numbered straight chain 2,3,4-saturated fatty aldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5227009", "l": "ABCF1 binds EIF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55663", "l": "2 AH2 + all-trans-beta-carotene + 2 O2 <=> 2 A + echinenone + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013157", "l": "CDC42 binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62451", "l": "holo-[peptidyl-carrier protein] + L-glutamyl-5'-AMP <=> AMP + H(+) + L-glutamyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24201", "l": "4-aminobenzoate + H(+) => aniline + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20981", "l": "2 bilirubin IXalpha + O2 => 2 biliverdin IXalpha + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848930", "l": "PTK6 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23837", "l": "D-methionine + pyruvate => 4-methylsulfanyl-2-oxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38597", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31612", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene => H2O + rhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63274", "l": "1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45915", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH <=> a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64123", "l": "an N-(fatty acyl)-L-serine + H2O <=> a fatty acid + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73453", "l": "adenosine 3',5'-bisphosphate(out) + AMP(in) => adenosine 3',5'-bisphosphate(in) + AMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69960", "l": "6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177942", "l": "EGFR binds EGF ligand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807144", "l": "HTN1,HTN3 or HTN5 binds the bacterial anionic surface  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37012", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985343", "l": "RUNX2 binds SOX9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0004993", "l": "G protein-coupled serotonin receptor activity", "d": ["Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30806", "l": "4-aminobutanal + H2O + NADP(+) <=> 4-aminobutanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004858", "l": "dUTP pyrophosphatase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of dUTP pyrophosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2423785", "l": "CR:atREs binds apoE and HSPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63354", "l": "(9Z)-octadecenoyl-CoA + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + octadecanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50095", "l": "a fatty acyl-CoA + taurine <=> an N-fatty acyl-taurine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72423", "l": "(E)-4-coumaroyl-AMP + CoA = (E)-4-coumaroyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56194", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71063", "l": "L-arginine(in) + L-histidine(out) = L-arginine(out) + L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695834", "l": "Constitutive phosphorylation of FLT3 mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64518", "l": "H(+) + NADH + sulfoacetaldehyde => 2-hydroxyethane-1-sulfonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109639", "l": "Formation of the closed pre-initiation complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28447", "l": "1-deoxy-D-xylulose(in) => 1-deoxy-D-xylulose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58871", "l": "24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217152", "l": "Formation of a multi-protein complex, cohesin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27811", "l": "dimethylallyl diphosphate + 2 isopentenyl diphosphate => (2Z,6Z)-farnesyl diphosphate + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944457", "l": "MAF1 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29790", "l": "ATP + glutathione(in) + H2O <=> ADP + glutathione(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10346", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54384", "l": "a 3-oxo-5alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11391", "l": "an 11beta-hydroxysteroid + NADP(+) <=> an 11-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683735", "l": "CHEK2 is recruited to DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54356", "l": "3-methyl-2-oxobutanoate + H(+) = 2-methylpropanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10606", "l": "a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45404", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate = 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31365", "l": "2 H(+) + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n) => NADP(+) + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167415", "l": "G-protein alpha subunit is inactivated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70481", "l": "TPI1 isomerizes GA3P to DHAP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52581", "l": "ATP + H2O + Pb(2+)(in) => ADP + H(+) + Pb(2+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784765", "l": "p-Y705-STAT3 dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16126", "l": "ATP + D-fructose => ADP + D-fructose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954056", "l": "E2F6 binds TFDP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4332356", "l": "CAMK2 binds MAP3K7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689649", "l": "BAP1 binds BRCA1:BARD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465926", "l": "An atROL isomerase isomerises atROL to 11cROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10663", "l": "L-seryl-[protein] <=> D-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46848", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) = 5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71552", "l": "5-N(alpha)-glycyl-dTMP in DNA + AH2 + S-adenosyl-L-methionine => 5'-deoxyadenosine + 5-C(alpha)-glycyl-dTMP in DNA + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22228", "l": "H(+) + NADH + presqualene diphosphate = diphosphate + NAD(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57469", "l": "(E)-ferulate + UDP-alpha-D-glucose => 1-O-[(E)-feruloyl]-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73349", "l": "beta-alanyl-tryptamine + H(+) + holo-[peptidyl-carrier protein] => beta-alanyl-[peptidyl-carrier protein] + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983427", "l": "Expression of peptide bound class I MHC on cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948757", "l": "AKT phosphorylates MKRN1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45861", "l": "12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140752", "l": "branched 1,3-beta-D-glucan synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + a branched [(1->3)-beta-D-glucosyl](n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55585", "l": "an adenosine in mRNA + S-adenosyl-L-methionine => an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141409", "l": "Mad1 binds kinetochore (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19309", "l": "2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate", "d": []}, {"i": "EC:3.1.3.70", "l": "\"mannosyl-3-phosphoglycerate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9676264", "l": "Formation of the SET1B complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050551", "l": "myrcene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = diphosphate + myrcene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49622", "l": "D-erythrulose 1-phosphate + H(+) + NADPH => D-erythritol 1-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52572", "l": "butanoyl-CoA + NAD(+) = (2E)-butenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912357", "l": "ITCH ubiquitinates DTX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.99.1", "l": "\"triphosphate--protein phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31780", "l": "an all-trans-retinyl ester + H2O => 13-cis-retinol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39696", "l": "3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH => (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69326", "l": "4-methylsulfanylbutyl isothionate + H(+) + sulfate => (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182286", "l": "Transport of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.363", "l": "\"ginsenoside 20-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617676", "l": "HOXA3 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2509838", "l": "ITPA hydrolyses dITP to dIMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170149", "l": "Translocation of active Cdc25C to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73284", "l": "H(+)(out) + L-isoleucine(in) => H(+)(in) + L-isoleucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47634", "l": "5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098624", "l": "3'-phosphoadenylylselenate reductase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylylselenate + NADPH => adenosine 3',5'-bisphosphate + selenite + NADP+ + H+."]}, {"i": "REACT:R-HSA-2408548", "l": "PAPSe is reduced to SeO3(2-) by PAPSe reductase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64527", "l": "(2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA <=> 2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23305", "l": "atropine + H2O => H(+) + tropate + tropine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047733", "l": "CDP-glucose 4,6-dehydratase activity", "d": ["Catalysis of the reaction: CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30508", "l": "2-demethylmenaquinone-8 + H(+) + NADH => 2-demethylmenaquinol-8 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627106", "l": "SMAC (DIABLO) forms dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25974", "l": "4-acetamidobutanal + H2O2 + propane-1,3-diamine => H2O + N(8)-acetylspermidine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797810", "l": "PTPRD binds IL1RAPL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11901", "l": "(2R,3S)-homoisocitrate + NAD(+) => 2-oxoadipate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33340", "l": "(4R)-hydroxysphinganine + hexacosanoyl-CoA => CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696358", "l": "TREM,CD300 binds lipids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004117", "l": "calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity", "d": ["Catalysis of the reactions: 3',5'-cyclic AMP + H2O = AMP + H+ and 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin."]}, {"i": "REACT:R-HSA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5432825", "l": "HMGB1 binds TLR4:LY96 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68850", "l": "diphosphate + gamma-cadinene => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23344", "l": "a purine D-ribonucleoside + H2O = a purine nucleobase + D-ribose", "d": []}, {"i": "EC:3.2.2.1", "l": "\"purine nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102410", "l": "quercetin-4',3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: quercetin 4'-O-glucoside + UDP-alpha-D-glucose(2-) <=> quercetin 3,4'-O-diglucoside + UDP(3-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57030", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+) => FADH2 + N-methylnicotinate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733973", "l": "Bile salts bind FABP6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111883", "l": "Hydrolysis of phosphatidylcholine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989757", "l": "Expression of FADS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62321", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) => (+)-isomalbrancheamide B + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49843", "l": "(-)-dehydrodiconiferyl acid + 2 a quinone + H2O <=> (-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50781", "l": "NADP(+) + octanal => (2E)-octenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35182", "l": "6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA <=> 7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73874", "l": "(R)-noradrenaline(out) <=> (R)-noradrenaline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30738", "l": "1D-myo-inositol 4-phosphate + H2O <=> myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018763", "l": "hydroxydechloroatrazine ethylaminohydrolase activity", "d": ["Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41181", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+) => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72562", "l": "estrone 3-sulfate(out) + pentanoate(in) <=> estrone 3-sulfate(in) + pentanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1861789", "l": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730840", "l": "Activation of RAC1 by VAV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709831", "l": "HSP90 binds TBK1 and IRF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47147", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61803", "l": "ATP + holo-[peptidyl-carrier protein] + L-alanine <=> AMP + diphosphate + L-alanyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042283", "l": "dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity", "d": ["Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665697", "l": "ERBB2 TMD/JMD mutants hetrodimerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2219524", "l": "PDPK1 binds PIP2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66031", "l": "AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine <=> (5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866304", "l": "pre-VLDL binds lipids to form VLDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29328", "l": "(S)-malate(in) + succinate(out) => (S)-malate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72846", "l": "3'-dephospho-CoA(in) + ADP(out) <=> 3'-dephospho-CoA(out) + ADP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023941", "l": "MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3828025", "l": "DCN (decorin) degradation by MMP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.44", "l": "\"phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19996", "l": "[thioredoxin]-disulfide + H2O + L-methionine <=> [thioredoxin]-dithiol + L-methionine (S)-S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008532", "l": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389026", "l": "Galanin receptors can bind galanin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24627", "l": "ATP + L-threonine + tRNA(Thr) <=> AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205231", "l": "Dimerization of KIT upon SCF binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13241", "l": "ATP + L-fucose = ADP + beta-L-fucose 1-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.52", "l": "\"fucokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.78", "l": "\"arogenate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60231", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22145", "l": "cis-aconitate + H2O => D-threo-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008452", "l": "RNA ligase activity", "d": ["Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the 5'-phosphate group at the end of another."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69577", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoadipate + H(+) => (R)-N6-(S8-glutaryldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21177", "l": "L-idonate + NADP(+) => 5-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016871", "l": "cycloartenol synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013435", "l": "RHOD auto-activates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66911", "l": "acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine <=> 9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210913", "l": "NEUROG3-dependent synthesis of INSM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237129", "l": "Acireductone is created (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917987", "l": "TFRC dimer binds 2xholoTF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49797", "l": "an N-(fatty acyl)-glycine + H2O => a fatty acid + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784861", "l": "HSPG binds LPL dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53073", "l": "2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate => 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016216", "l": "isopenicillin-N synthase activity", "d": ["Catalysis of the reaction: N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = 2 H2O + isopenicillin N."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683624", "l": "mRNA2 is translated to Spike (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950608", "l": "Expression U2 small nuclear ribonucleoprotein A' (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800793", "l": "PIDD1 translocates to the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70098", "l": "(R)-5-methyl-tetronate + o-quinone methide <=> peniphenone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954082", "l": "E2F6 binds the PRC1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140311", "l": "protein sequestering activity", "d": ["Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18509", "l": "H(+) + H2O2 + NADH = 2 H2O + NAD(+)", "d": []}, {"i": "EC:1.11.1.1", "l": "\"NADH peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168809", "l": "SOCS binding to GHR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44037", "l": "12,13-epoxy-(9Z)-octadecenoate + H2O => 12,13-dihydroxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61755", "l": "steviolbioside + UDP-alpha-D-glucose <=> H(+) + rebaudioside B + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32107", "l": "3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine = H(+) + pterostilbene + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71680", "l": "H(+)(out) + L-lysyl-glycine(out) => H(+)(in) + L-lysyl-glycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483087", "l": "PI is exchanged with PC by PITPNB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65848", "l": "A + a 3-oxo-Delta(1)-steroid + H2O = a steroid 1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47338", "l": "16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444572", "l": "Zinc is an agonist of GPR39 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30631", "l": "alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate = beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.264", "l": "\"D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202174", "l": "Activation of ZAP-70 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010293", "l": "abscisic aldehyde oxidase activity", "d": ["Catalysis of the reaction: (+)-abscisic aldehyde + H2O + O2 = abscisate + H2O2 + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69350", "l": "(E)-prop-1-en-1-SO-peroxol + 2-aminoprop-2-enoate => S-1-propenyl-L-cysteine sulfoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1013020", "l": "Activation of GIRK/Kir3 Channels (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-976801", "l": "Complement factor I complex formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53209", "l": "daidzein + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3204303", "l": "MRE11 binds cytosolic DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981622", "l": "Myoglobin:oxygen dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59076", "l": "bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+)", "d": []}, {"i": "EC:2.4.1.361", "l": "\"GDP-mannose:di-myo-inositol-1,3'-phosphate beta-1,2-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592297", "l": "Full activation of MMP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029273", "l": "PI3K binds to p-6Y-SYK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43263", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76052", "l": "Binding of TFIIIA To type 1 Promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202472", "l": "Translocation of TRAF6 to CBM complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63060", "l": "5-methylorsellinate + ATP + H(+) + NADPH = 2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53205", "l": "17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] => 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15615", "l": "2 H(+) + NADH + sirohydrochlorin => NAD(+) + precorrin-2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052734", "l": "shikimate 3-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: shikimate + NAD+ = 3-dehydroshikimate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23972", "l": "(2E)-glutaconyl-CoA + H(+) + Na(+)(in) = (2E)-butenoyl-CoA + CO2 + Na(+)(out)", "d": []}, {"i": "EC:7.2.4.5", "l": "\"glutaconyl-CoA decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44976", "l": "(R)-carnitine + propanoyl-CoA = CoA + O-propanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17678", "l": "2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O => 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49311", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O <=> a neolactoside nLc4Cer(d18:0) + L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23753", "l": "all-trans-undecaprenol + ATP => ADP + all-trans-undecaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139898", "l": "Caspase-8 activates BID by cleavage (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42451", "l": "(R)-2-hydroxyglutaryl-CoA <=> (2E)-glutaconyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849428", "l": "PTPN1 binds PTK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69351", "l": "S-1-propenyl-L-cysteine sulfoxide <=> (E)-prop-1-en-1-SO-peroxol + 2-aminoprop-2-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10076", "l": "H2O + lactose = beta-D-galactose + D-glucose", "d": []}, {"i": "EC:3.2.1.108", "l": "\"lactase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66294", "l": "an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+) => an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182279", "l": "Formation of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19937", "l": "glycine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + sarcosine", "d": []}, {"i": "EC:2.1.1.20", "l": "\"glycine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38525", "l": "(9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+) => 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944242", "l": "Association of procollagen type XXVII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57804", "l": "1-chloro-3-nitrobenzene + NADH + O2 = 4-chlorocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27573", "l": "ATP + D-glycero-alpha-D-manno-heptose 7-phosphate <=> ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.9", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905131", "l": "carcinine transmembrane transporter activity", "d": ["Enables the transfer of carcinine from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39526", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA <=> (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37046", "l": "ATP + H2O + L-alanyl-L-glutamate(out) <=> ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68832", "l": "(2Z,6Z)-farnesyl diphosphate + H2O = (6Z)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696958", "l": "USP44 deubiquitinates CDC20 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68764", "l": "(R)-3-phenyllactate + 3 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022D + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67421", "l": "a glycerophospholipid + H2O => a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623415", "l": "FOXO1,FOXO3,FOXO4 bind IGFBP1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005540", "l": "hyaluronic acid binding", "d": ["Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004598", "l": "peptidylamidoglycolate lyase activity", "d": ["Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050036", "l": "L-threonate 3-dehydrogenase activity", "d": ["Catalysis of the reaction: L-threonate + NAD+ = 3-dehydro-L-threonate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59468", "l": "an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57189", "l": "H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] => glycolate + H(+) + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69716", "l": "(indol-3-yl)acetate + ATP + CoA => (indol-3-yl)acetyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013159", "l": "CDC42 GEFs activate CDC42 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68026", "l": "phosphate + presqualene alcohol => H2O + presqualene monophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48163", "l": "3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] <=> epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031827", "l": "type 2B serotonin receptor binding", "d": ["Binding to a type 2B serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12599", "l": "CoA + H(+) + N-acetylphosphinothricin => acetyl-CoA + phosphinothricin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49569", "l": "2-glutathionyl-2-methylbut-3-en-1-ol => (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32280", "l": "allantoate + 2 H(+) + 2 H2O => (S)-ureidoglycolate + CO2 + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031963", "l": "nuclear cortisol receptor activity", "d": ["Combining with cortisol and transmitting the signal within the cell to trigger a change in cell activity or function."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31610", "l": "rhodopin <=> all-trans-lycopene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443418", "l": "GP1b signaling involves c-Src (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27609", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694409", "l": "Nucleotide exchange on RAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2512800", "l": "SCARB1:ligand is endocytosed (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41525", "l": "5 H(+) + 5 malonyl-CoA => 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17407", "l": "H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine => N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48759", "l": "erythritol + NAD(+) <=> D-erythrulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57626", "l": "3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640368", "l": "Addition of Tegument to HCMV Nucleocapsid C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954117", "l": "E2F6:TFDP1 binds EPC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75875", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72870", "l": "3',3',3'-cAAG + H2O <=> A[3'-5']pG[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358791", "l": "Phosphorylation of USP8 by P-AKT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71072", "l": "L-arginine(in) + L-cysteine(out) => L-arginine(out) + L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3204311", "l": "AOX1 oxidises PXL to PDXate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106389", "l": "ecdysteroid 22-kinase activity", "d": ["Catalysis of the reaction: an ecdysteroid + ATP = an ecdysteroid 22-phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199910", "l": "MSK1 activates ATF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199579", "l": "KIR2DL4 interacting with HLA-G (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74021", "l": "glycine(in) + L-alanine(out) => glycine(out) + L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102711", "l": "gibberellin A25,oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A25 + 2-oxoglutarate + O2 <=> gibberellin A13 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42920", "l": "S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.193", "l": "\"16S rRNA (uracil(1498)-N(3))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66261", "l": "CoA + IC-asc-C7-AMP => AMP + H(+) + IC-asc-C7-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097063", "l": "cadmium ion sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47162", "l": "3-dehydro-4-methylzymosterol + CO2 + NADH => 4beta-methylzymosterol-4alpha-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34566", "l": "CDP-alpha-D-abequose + NADP(+) <=> CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43039", "l": "L-cysteine <=> 2-aminoprop-2-enoate + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72683", "l": "cholate(out) = cholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66831", "l": "2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109702", "l": "PDPK1 phosphorylates AKT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67031", "l": "(glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O <=> (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265177", "l": "Exocyst complex formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62661", "l": "2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol => (2'R)-atrovenetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59949", "l": "H2O + prostaglandin F2alpha-CoA => CoA + H(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797803", "l": "PTPRD binds SLITRK1-6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621573", "l": "CD209 activate GTPase RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74702", "l": "(5R)-hydroxy-beta-trans-bergamotene + O2 <=> (3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611751", "l": "β1,2-agonists bind ADRB1,2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53918", "l": "CoA + H(+) + N(6)-acyl-L-lysyl-[protein] => an acyl-CoA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852331", "l": "GTSE1 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72585", "l": "3,22-dioxochol-4-en-24-oyl-CoA + H(+) + NADH => (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37418", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68611", "l": "Formation of ORC(1-5) complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26076", "l": "H2O + UDP-alpha-D-glucuronate <=> D-glucuronate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938507", "l": "miR-106a binds RUNX1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9696275", "l": "RND2 binds GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41861", "l": "(3R)-hydroxydecanoyl-[ACP] => (2E)-decenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22396", "l": "1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 = glycolaldehyde + guaiacol + H2O + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956639", "l": "RUNX1 binds YAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166544", "l": "TrkA receptor autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632393", "l": "TP63/TP53 bind the DDIT4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863463", "l": "STON2 binds SYT proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23083", "l": "L-rhamnonate <=> 2-dehydro-3-deoxy-L-rhamnonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647632", "l": "CASP3 cleaves GSDME (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696146", "l": "AOC2 deaminates TYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65582", "l": "H(+) + phosphate + TDP => H2O + TTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683925", "l": "ULK1 is dephosphorylated (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54932", "l": "(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] = (2E,9Z)-hexadecadienoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10480", "l": "2-oxoglutarate + 4-hydroxy-L-glutamate = 4-hydroxy-2-oxoglutarate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20594", "l": "H2O + N-acetyl-D-glucosamine => acetate + D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373732", "l": "Nephrin trans-homophilic interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42032", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate", "d": []}, {"i": "EC:1.14.11.27", "l": "\"[histone H3]-dimethyl-L-lysine(36) demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3777129", "l": "HDAC3 containing complexes deacetylate histone (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102684", "l": "L-phenylalanine N-monooxygenase activity", "d": ["Catalysis of the reaction: L-phenylalanine + 2 NADPH + 2 O2 + 2 H+ <=> (E)-phenylacetaldehyde oxime + 2 NADP + 3 H2O + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38458", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37242", "l": "2',3'-cyclophospho-UMP + H2O <=> H(+) + uridine 2'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13236", "l": "guanosine + phosphate <=> alpha-D-ribose 1-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109702", "l": "PDPK1 phosphorylates AKT2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19556", "l": "H2O + L-tryptophan <=> indole + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-873917", "l": "Translocation of STAT1 dimer to nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49870", "l": "(+)-dehydrodiconiferyl acid ketone + a quinol => (+)-dehydrodiconiferyl acid + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13903", "l": "N-(hydroxymethyl)urea + NH4(+) => H2O + N-(aminomethyl)urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37384", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28895", "l": "cadaverine(in) + L-lysine(out) = cadaverine(out) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877153", "l": "STARD7 binds PC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045353", "l": "interleukin-1 type II receptor antagonist activity", "d": ["Blocks the binding of interleukin-1 to interleukin-1 type II receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69503", "l": "L-arginyl-[protein] + NAD(+) <=> ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032190", "l": "acrosin binding", "d": ["Binding to acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61270", "l": "2-oxohexanoate + H2O2 + NH4(+) => H2O + L-2-aminohexanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990833", "l": "clathrin-uncoating ATPase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the removal of clathrin from vesicle membranes, coupled to the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086083", "l": "SUMOylation of ING2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46346", "l": "3-oxo-2-methylhexadecanoyl-CoA + CoA => propanoyl-CoA + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27597", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 5 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004026", "l": "alcohol O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031837", "l": "substance K receptor binding", "d": ["Binding to a substance K receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49021", "l": "2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395340", "l": "Formation of hydroxyallysine by LOX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58526", "l": "(16S)-deshydroxymethyl-stemmadenine + formate + NADP(+) => 15alpha-stemmadenine intermediate I + H2O + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22224", "l": "3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O", "d": []}, {"i": "EC:2.3.1.159", "l": "\"acridone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617829", "l": "Assembly of IFT A complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47539", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isochenodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26273", "l": "Co-precorrin-3 + S-adenosyl-L-methionine = Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36596", "l": "hydrogen sulfide + NADP(+) => NADPH + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29287", "l": "2 H(+)(in) + L-aspartate(in) = 2 H(+)(out) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033718", "l": "pyranose dehydrogenase (acceptor) activity", "d": ["Catalysis of the reactions: pyranose + acceptor = 2-dehydropyranose (or 3-dehydropyranose or 2,3-didehydropyranose) + reduced acceptor, and a pyranoside + acceptor = a 3-dehydropyranoside (or 3,4-didehydropyranoside) + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807106", "l": "PTEN undergoes monoubiquitination (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32176", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose => alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35185", "l": "4-carboxy-2-thioxobutanoyl-CoA => 5-hydroxythiophene-2-carbonyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102317", "l": "4-methylaminobutyrate oxidase (demethylating) activity", "d": ["Catalysis of the reaction: 4-(methylamino)butyric acid + O2 + H2O <=> gamma-aminobutyric acid + formaldehyde + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49913", "l": "(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2530445", "l": "CD59 inhibits MAC formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664867", "l": "NBR1 binds MAP1LC3B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27605", "l": "(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate <=> di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62877", "l": "AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate => A + semiviriditoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30942", "l": "ATP + dIDP <=> ADP + dITP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755765", "l": "C-ter TLR7 dimer binds SARS-CoV-2 GU-rich ssRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689111", "l": "PARK2 autoubiquitinates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0047291", "l": "lactosylceramide alpha-2,3-sialyltransferase activity", "d": ["Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19851", "l": "ADP-D-ribose 2'-phosphate + H(+) + nicotinamide => H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202111", "l": "AKT1 phosphorylates eNOS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.24", "l": "\"quinate/shikimate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129357", "l": "Fibrillin C-terminal processing (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33477", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75268", "l": "D-arabinose + NADP(+) => D-arabinono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66247", "l": "ATP + H(+) + IC-asc-C9 <=> diphosphate + IC-asc-C9-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645134", "l": "p-STAT5 dissociates from activator:STAT5 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41273", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72095", "l": "Internal Methylation of mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48632", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.2.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62763", "l": "4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404139", "l": "HSC cytosolic atROL translocates to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444202", "l": "Receptor FFAR1 binds free fatty acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204863", "l": "Interaction of Tie2 with Ang2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43464", "l": "H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388833", "l": "Phosphorylation of CTLA-4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36687", "l": "hexadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392748", "l": "L1 binds to AP-2 Clathrin complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49009", "l": "aurachin C + H(+) + NADPH + O2 => aurachin C epoxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51424", "l": "a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103015", "l": "4-amino-4-deoxy-L-arabinose transferase activity", "d": ["Catalysis of the reaction: (Kdo)2-lipid A + 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,poly-cis-undecaprenyl phosphate = (beta-L-Ara4N)2-(KDO)2-lipid A + 2 ditrans,polycis-undecaprenyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3858482", "l": "DVL is recruited to the receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26440", "l": "3-oxopropanoate + H(+) + NADPH => 3-hydroxypropanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24192", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) = (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73132", "l": "8-hydroxy-7-methoxyflavone + S-adenosyl-L-methionine => 7,8-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391933", "l": "EP3 receptor can bind PGE2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34213", "l": "ecgonone methyl ester + H(+) + NADPH => ecgonine methyl ester + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950342", "l": "EBI3:CANX binds IL27 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68138", "l": "(R)-1-phenylethanol + NADP(+) => acetophenone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18727", "l": "acetyl-CoA + vanillin => 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17296", "l": "2 H(+) + NADH + O2 + precorrin-3A <=> H2O + NAD(+) + precorrin-3B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-997237", "l": "SH2B proteins bind JAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52233", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + Fe(2+) + 3 H2O + mycobilin a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75912", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine => a fatty acid + H(+) + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050286", "l": "sorbitol-6-phosphatase activity", "d": ["Catalysis of the reaction: D-glucitol 6-phosphate + H2O = D-glucitol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445704", "l": "Calcium Binds Caldesmon (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62024", "l": "campesteryl 3-beta-D-glucoside + H2O = campesterol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44116", "l": "eicosan-1-ol + hexadecanoyl-CoA = CoA + eicosanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534240", "l": "HSPG2 (perlecan) degradation by MMP14, MMP15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602466", "l": "Activation of MT-MMPs by FURIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12666", "l": "a 2-deoxystreptamine antibiotic + acetyl-CoA => an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25848", "l": "(1S,5S)-carveol + NAD(+) = (S)-carvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030233", "l": "deoxynucleotide transmembrane transporter activity", "d": ["Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168136", "l": "NOTCH3 binds DLL4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168459", "l": "Lyn activates ERK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794444", "l": "ALB binds Cipro (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45572", "l": "[(1->4)-beta-D-mannuronosyl](n) = [alginate](n)", "d": []}, {"i": "EC:5.1.3.37", "l": "\"mannuronan 5-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66514", "l": "1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12086", "l": "D-fructose + H(+) + NADH => D-mannitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45681", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) => N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50221", "l": "(S)-demethyl-4-deoxygadusol => (R)-demethyl-4-deoxygadusol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52273", "l": "(1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine => gramine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50513", "l": "acetyl-CoA + N-terminal L-cysteinyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12551", "l": "2-cis,4-trans-xanthoxin + NAD(+) <=> 2-cis-(+)-abscisic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33302", "l": "[eIF5A protein]-L-lysine + spermidine <=> [eIF5A protein]-deoxyhypusine + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75794", "l": "(S)-lactate(out) + Na(+)(out) <=> (S)-lactate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168445", "l": "PTP1B binds the GH receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.73", "l": "\"lipopolysaccharide glucosyltransferase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57912", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) = H(+) + L-glutaminyl-tRNA(Gln) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354273", "l": "AP-1 transcription factor forms a complex with STAT92E and DSP1 which displaces REL-68 from its target gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877153", "l": "STARD7 binds PC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202212", "l": "Recruitment of PLC-gamma1 to LAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20960", "l": "1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate", "d": []}, {"i": "EC:3.1.3.26", "l": "\"4-phytase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034554", "l": "3,3',5-tribromobisphenol A reductive dehalogenase activity", "d": ["Catalysis of the reaction: 3,3',5-tribromobisphenol A + 2 H+ + 2 e- = 3,3'-dibromobisphenol A + HBr."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10874", "l": "a carboxylate + L-aspartate => H2O + N-acyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65652", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine = a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:1901239", "l": "malonate(1-) transmembrane transporter activity", "d": ["Enables the transfer of malonate(1-) from one side of a membrane to the other."]}, {"i": "RHEA:33115", "l": "malonate(in) = malonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050244", "l": "pyruvate oxidase (CoA-acetylating) activity", "d": ["Catalysis of the reaction: CoA + H+ + O2 + pyruvate = acetyl-CoA + CO2 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112727", "l": "Serine phosphorylation of STATs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24484", "l": "NAD(+) + sulcatol = H(+) + NADH + sulcatone", "d": []}, {"i": "EC:1.1.1.260", "l": "\"sulcatone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39110", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12541", "l": "ATP + L-alanine + tRNA(Ala) => AMP + diphosphate + L-alanyl-tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11088", "l": "H2O + trimetaphosphate = 2 H(+) + triphosphate", "d": []}, {"i": "EC:3.6.1.2", "l": "\"trimetaphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2870221", "l": "E-selectin binds E-selectin ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-984671", "l": "Chromokinesins form dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27332", "l": "H(+) + NADH + O2 + urate <=> 5-hydroxyisourate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19559", "l": "9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O => AH2 + O2 + pregna-4,9(11)-diene-3,20-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.266", "l": "\"glucosyl-3-phosphoglycerate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69175", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] <=> (2E)-2-butenoate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33697", "l": "3-oxoeicosasphinganine + H(+) + NADPH => C20 sphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471314", "l": "HNP1-3 bind CD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37231", "l": "H2O + L-alaninamide = L-alanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46310", "l": "17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694427", "l": "MIA3 binds procollagen VII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411383", "l": "NLK phosphorylates TCF/LEF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67385", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha,25-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16546", "l": "formyl-CoA + oxalate => formate + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15967", "l": "1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983426", "l": "Capturing cargo and formation of prebudding complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001618", "l": "virus receptor activity", "d": ["Combining with a virus component and mediating entry of the virus into the cell."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047566", "l": "3-ketovalidoxylamine C-N-lyase activity", "d": ["Catalysis of the reaction: 4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389523", "l": "BTLA interacts with HVEM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64657", "l": "(E)-sinapaldehyde + CoA + NADP(+) => (E)-sinapoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51090", "l": "13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14651", "l": "demethylmacrocin + dTDP + H(+) => demethyllactenocin + dTDP-beta-L-mycarose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52201", "l": "1-aci-nitro-2-(phenyl)ethane + glutathione => (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54292", "l": "ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0003954", "l": "NADH dehydrogenase activity", "d": ["Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66174", "l": "H(+)(in) + L-cystine(in) => H(+)(out) + L-cystine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018844", "l": "2-hydroxytetrahydrofuran isomerase activity", "d": ["Catalysis of the reaction: 2-hydroxytetrahydrofuran = 4-hydroxybutyraldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188985", "l": "trehalose + H2O => 2 D-glucose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810030", "l": "MTMR2 binds MTMR10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730847", "l": "Hydrolysis of PIP2 by PLCG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50952", "l": "7-chloro-L-tryptophan + AH2 + O2 = A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888577", "l": "Synthesis of GABA by GAD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40385", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24500", "l": "adenosine 5'-tetraphosphate + H2O = ATP + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.14", "l": "\"adenosine-tetraphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61632", "l": "5-aminopentanal + H2O + NAD(+) = 5-aminopentanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18310", "l": "an N-acyl-D-amino acid + H2O => a carboxylate + a D-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016603", "l": "glutaminyl-peptide cyclotransferase activity", "d": ["Catalysis of the reaction: N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42166", "l": "(5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69900", "l": "2 Na(+)(out) + thymidine(out) => 2 Na(+)(in) + thymidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5323526", "l": "FRAT proteins bind GSK3beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2059926", "l": "NPHP4 protein binds LATS proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3782535", "l": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129357", "l": "Fibrillin C-terminal processing (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66889", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38423", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33897", "l": "H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose => NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433608", "l": "ceramide + H2O => stearate + sphingosine [endoplasmic reticulum] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46127", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983266", "l": "Kinesins bind microtubules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694442", "l": "CNIH2,3 bind GRIA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35399", "l": "1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine = beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)", "d": []}, {"i": "EC:2.3.1.213", "l": "\"cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) 6'''-O-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265177", "l": "Exocyst complex formation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67932", "l": "ATP + desmosterol(in) + H2O = ADP + desmosterol(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799350", "l": "Exocytosis of specific granule membrane proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40568", "l": "AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 => A + dTDP-beta-L-evernitrose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14919", "l": "4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008389", "l": "coumarin 7-hydroxylase activity", "d": ["Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665409", "l": "GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614591", "l": "Excess cysteine yields lanthionine and H2S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45528", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11628", "l": "a 2-oxocarboxylate + H(+) = an aldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50609", "l": "leukotriene B4 + NADP(+) => 12-oxo-leukotriene B4 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42068", "l": "(3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH = clavulanate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69621", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.261", "l": "\"(4-hydroxyphenyl)alkanoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48195", "l": "(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10054", "l": "4-methyl-2-oxopentanoate + H(+) + NADH => (R)-2-hydroxy-4-methylpentanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67521", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047214", "l": "cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin-3-O-D-rhamnosyl-(1,6)-D-glucoside + UDP-D-glucose = cyanidin-3-O-[D-rhamnosyl-(1,6)-D-glucoside]-5-O-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70217", "l": "20beta-dihydrocortisol + NADP(+) => cortisol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51569", "l": "(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10207", "l": "dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] <=> formaldehyde + methylamine + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-169895", "l": "Crk's SH3 domain engages C3G (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211206", "l": "Translocation of DFF to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444476", "l": "FPRL2 receptor binds a wide range of ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51587", "l": "4-(trimethylamino)butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25888", "l": "dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate", "d": []}, {"i": "EC:2.5.1.72", "l": "\"quinolinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27718", "l": "H2O + IMP = inosine + phosphate", "d": []}, {"i": "EC:3.1.3.99", "l": "\"IMP-specific 5'-nucleotidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696547", "l": "STAMBPL1 is a deubiquitinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086083", "l": "SUMOylation of ING2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41831", "l": "(3R)-hydroxyhexanoyl-[ACP] <=> (2E)-hexenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40604", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O => (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9658253", "l": "RAS:GTP binds PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49129", "l": "AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11746", "l": "H(+) + phosphate + thiamine diphosphate => H2O + thiamine triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5617828", "l": "TRIP11:IFT20 dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166214", "l": "FA anion flip-flops to the opposite surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31583", "l": "2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+)", "d": []}, {"i": "EC:3.6.1.56", "l": "\"2-hydroxy-dATP diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38212", "l": "hexadecane-1,2-diol + 2 hexadecanoyl-CoA => 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734590", "l": "NKX2-5 binds the GATA6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12833", "l": "an N-acyl-D-glutamate + H2O = a carboxylate + D-glutamate", "d": []}, {"i": "EC:3.5.1.82", "l": "\"N-acyl-D-glutamate deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199299", "l": "AKT phosphorylates FOXO transcription factors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810843", "l": "Envoplakin binds periplakin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873927", "l": "Release of STAT1 dimer from active receptor unit (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685319", "l": "CX3 complex formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140661", "l": "cytoskeletal motor inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a motor protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198983", "l": "NKG2D homodimer interacting with ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17871", "l": "6,7-dihydropteridine + H(+) + NADH => 5,6,7,8-tetrahydropteridine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798474", "l": "S100A8:S100A9 binds Zn2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52471", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15700", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047097", "l": "phylloquinone monooxygenase (2,3-epoxidizing) activity", "d": ["Catalysis of the reaction: AH(2) + O2 + phylloquinone = 2,3-epoxyphylloquinone + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839638", "l": "CTNNB1 T41 mutants aren't phosphorylated by GSK3beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.916538309327947", "identifiers": [{"i": "GO:0015645", "l": "fatty acid ligase activity", "d": ["Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.1.6", "l": "\"acetolactate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.102", "l": "\"phenacrylate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202325", "l": "Recruitment of Gads to LAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25360", "l": "(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] => biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50547", "l": "prostaglandin C2 <=> prostaglandin B2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428917", "l": "G13 activation by TP receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53122", "l": "5alpha-dihydrotestosterone sulfate + H(+) + NADPH => (3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72535", "l": "H2O + NADP(+) + vanillin = 2 H(+) + NADPH + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62271", "l": "(R)-2-hydroxy-3-methylbutyrate + NADP(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.652932776586212", "identifiers": [{"i": "GO:0033764", "l": "steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative."]}, {"i": "REACT:R-HSA-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75237", "l": "L-fucono-1,4-lactone => L-fucono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72722", "l": "eIF2 activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68063", "l": "a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2512800", "l": "SCARB1:ligand is endocytosed (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21465", "l": "2 H(+) + H2O + thiocyanate => carbonyl sulfide + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57614", "l": "9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+) => 20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62901", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50078", "l": "19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53165", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63815", "l": "ATP + N(8)-citryl-spermidine + spermidine <=> AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13140", "l": "cycloartenol + S-adenosyl-L-methionine <=> cyclolaudenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39824", "l": "eicosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 2-hydroxyeicosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42382", "l": "2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+) => 2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805109", "l": "CDK2 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74305", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(+) + NADH => 12alpha-hydroxy-3-oxochola-4-en-24-oate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654404", "l": "Activated FGFR2 binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45147", "l": "3-(methylsulfanyl)acryloyl-CoA + 2 H2O <=> acetaldehyde + CO2 + CoA + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68603", "l": "ORC5 binds ORC2:ORC3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42926", "l": "2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58319", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.9.1", "l": "\"iron:rusticyanin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70818", "l": "H(+)(in) + L-histidine(in) + L-ornithine(out) <=> H(+)(out) + L-histidine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57221", "l": "GTP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858489", "l": "ppDVL binds DAAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34930", "l": "H(+) + NADPH + selenodiglutathione <=> glutathione + glutathioselenol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30612", "l": "A + all-trans-zeta-carotene => AH2 + all-trans-neurosporene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33178", "l": "4-hydroxyphenylacetate(in) <=> 4-hydroxyphenylacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685156", "l": "ATR phosphorylates RPA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019143", "l": "3-deoxy-manno-octulosonate-8-phosphatase activity", "d": ["Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H2O = 3-deoxy-D-manno-octulosonate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13597", "l": "1,4-diguanidinobutane + H2O = agmatine + urea", "d": []}, {"i": "EC:3.5.3.20", "l": "\"diguanidinobutanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37043", "l": "ATP + H2O + L-alanyl-L-glutamate(out) = ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928614", "l": "EFNB:GRB4 binds GIT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55942", "l": "all-trans-3,4-didehydroretinal + H(+) + NADH => all-trans-3,4-didehydroretinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10473", "l": "(2R,3S)-2,3-dimethylmalate => propanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875443", "l": "USP8 deubiquitinates LRIG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10205", "l": "dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] => formaldehyde + methylamine + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43977", "l": "H(+) + hexadecanoate + NADPH + O2 => 14-hydroxyhexadecanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64856", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + phomopsene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27684", "l": "ADP + dTTP => ATP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46956", "l": "hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.1.108", "l": "\"caffeoyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848596", "l": "PTK6 binds PXN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090422", "l": "thiamine pyrophosphate transmembrane transporter activity", "d": ["Enables the transfer of thiamine pyrophosphate a substance from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.968459345787338", "identifiers": [{"i": "GO:0004402", "l": "histone acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050460", "l": "hydroxylamine reductase (NADH) activity", "d": ["Catalysis of the reaction: NH3 + NAD+ + H2O = hydroxylamine + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45348", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62070", "l": "2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH => 2-deoxy-D-glucose 6-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23345", "l": "a purine D-ribonucleoside + H2O => a purine nucleobase + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623096", "l": "Delayed Early (DE) Gene Expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.162", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10305", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785213", "l": "LIPC dimer binds heparin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40358", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59369", "l": "1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222128", "l": "NOC2L binds TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22031", "l": "acetyl-CoA + taxa-4(20),11-dien-5alpha-ol <=> CoA + taxa-4(20),11-dien-5alpha-yl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876731", "l": "CHEST translocates from ER membrane to lipid particle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19831", "l": "an aldehyde + H2O2 => a primary alcohol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0031545", "l": "peptidyl-proline 4-dioxygenase activity", "d": ["Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2984226", "l": "PLK1 phosphorylates NEK9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12743", "l": "IDP + NH4(+) => ADP + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1564169", "l": "Collagen type VIII degradation by MMP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847968", "l": "PTEN binds FRK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362386", "l": "Glycosylation of Hh (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13674", "l": "[protein-PII]-L-tyrosine + UTP => [protein-PII]-uridylyl-L-tyrosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28907", "l": "3-(3-hydroxyphenyl)propanoate(in) + H(+)(in) = 3-(3-hydroxyphenyl)propanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11440", "l": "2,3,5,6-tetrachlorophenol + NADPH + O2 = 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174731", "l": "Degradation of newly synthesized ApoB-48 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981621", "l": "Neuroglobin:oxygen dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400219", "l": "Beta-TrCP1 binds phosphorylated PER proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49512", "l": "2-(phosphinatomethylidene)butanedioate + H2O = phosphinomethylisomalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36168", "l": "a 2'-deoxyribonucleoside 5'-phosphate + H2O => a 2'-deoxyribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59210", "l": "diphosphate + octadecanoyl-AMP => ATP + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54700", "l": "4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] = 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388828", "l": "PD-1 binds B7DC and B7H1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70443", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + O2 = a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42121", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) => 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.23", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045519", "l": "interleukin-23 receptor binding", "d": ["Binding to an interleukin-23 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786500", "l": "ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388829", "l": "SHP2 phosphatase binds CTLA-4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483186", "l": "PC is converted to PS by PTDSS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21780", "l": "A + cyclohexanone = AH2 + cyclohex-2-enone", "d": []}, {"i": "EC:1.3.99.14", "l": "\"cyclohexanone dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948136", "l": "ULK1 Translocates to the mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40224", "l": "4,8-dimethylnonanoyl-CoA + H2O => 4,8-dimethylnonanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448673", "l": "Formation of caspase-1 p10/p20 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086223", "l": "Collagen type IX binds integrin alpha11beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050095", "l": "methionine decarboxylase activity", "d": ["Catalysis of the reaction: L-methionine + H+ = 3-methylthiopropanamine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14805", "l": "ATP + D-allose = ADP + D-allose 6-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.55", "l": "\"allose kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202724", "l": "P-selectin binds P-selectin ligand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9658253", "l": "RAS:GTP binds PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62592", "l": "(S)-8-oxocitronellyl enol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69062", "l": "H2O + N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + NAD(+) => N(delta)-hydroxy-N(omega)-methyl-L-arginine + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63452", "l": "3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + H(+) + oxidized 3PG-factor420-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654159", "l": "Activated FGFR2 binds PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70573", "l": "argininosuccinate <=> fumarate + arginine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.1", "l": "\"rubredoxin--NAD(+) reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23650", "l": "dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH => dTDP-6-deoxy-beta-L-talose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66208", "l": "(8R)-8-hydroxynonanoyl-CoA + O2 = (2E,8R)-8-hydroxynonenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15398", "l": "dichloromethane + H2O => 2 chloride + formaldehyde + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17160", "l": "ATP + creatine <=> ADP + H(+) + N-phosphocreatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.5", "l": "\"prolyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72103", "l": "Formation of pre-mRNPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72633", "l": "Ca(2+)(out) + 3 Li(+)(in) => Ca(2+)(in) + 3 Li(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218811", "l": "DOCK180:ELMO binds CRK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611852", "l": "ADRB3 bind ADR,NAd (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65979", "l": "7-dehydrocholesterol + hnu <=> previtamin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071889", "l": "14-3-3 protein binding", "d": ["Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48449", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19111", "l": "1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+) => 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667563", "l": "AVPR2 bind desmopressin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430308", "l": "PARVB interacts with Alpha-actinin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210430", "l": "Release of L-Glutamate at the synapse (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050577", "l": "GDP-L-fucose synthase activity", "d": ["Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174731", "l": "Degradation of newly synthesized ApoB-48 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58174", "l": "beta-pinacene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31860", "l": "(S)-2,3-epoxysqualene => glutinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448673", "l": "Formation of caspase-1 p10/p20 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804383", "l": "PRMT5 methylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61418", "l": "cis-trans-nepetalactol => (S)-8-oxocitronellyl enol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15474", "l": "flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose => flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15429", "l": "heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.342", "l": "\"anaerobilin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52377", "l": "(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668831", "l": "CST complex formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58115", "l": "1''-O-acetyl-ADP-alpha-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013284", "l": "NOTCH3-ligand complex is cleaved to produce NEXT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.367", "l": "\"ginsenoside 6-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74724", "l": "isorhamnetin + S-adenosyl-L-methionine => 3',4'-O-dimethylquercetin + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62878", "l": "A + semiviriditoxin => AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102894", "l": "UDPG:cyclo-DOPA 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + leucodopachrome <=> H+ + cyclo-dopa 5-O-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13571", "l": "beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP => ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-168136", "l": "Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69994", "l": "3-dehydro-6-deoxoteasterone + NADP(+) <=> (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29972", "l": "2'-deoxyinosine(in) + H(+)(in) => 2'-deoxyinosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936703", "l": "sulfite is reduced to sulfide (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429767", "l": "Passive I- efflux mediated by SMCT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20266", "l": "2-oxoglutarate + L-proline + O2 => cis-3-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047492", "l": "xanthan lyase activity", "d": ["Catalysis of the reaction: xanthan = oligosaccharide with 4-deoxy-alpha-L-threo-hex-4-enuronosyl end + pyruvylate mannose. This reaction is the eliminative cleavage of the terminal beta-D-mannosyl-beta-D-1,4-glucuronosyl linkage of the side-chain of the polysaccharide xanthan, leaving a 4-deoxy-alpha-L-threo-hex-4-enuronosyl group at the terminus of the side-chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8960973", "l": "RLBP1:11cRAL dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32193", "l": "2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23380", "l": "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP", "d": []}, {"i": "EC:2.4.1.141", "l": "\"N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23827", "l": "(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) <=> 2,3-dihydroxybenzoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58512", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66198", "l": "CoA + H(+) + N-acetyltryptamine => acetyl-CoA + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75023", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate = 9-(9Z,12Z-octadecadienoyloxy)-octadecanoate + di-(9Z,12Z)-octadecadienoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75850", "l": "Addition of the third nucleotide on the nascent transcript (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592240", "l": "Formation of NRF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25187", "l": "2-chloroethanol + chloride + H(+) => 1,2-dichloroethane + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54021", "l": "L-lysyl-[protein] + propanoyl-CoA => CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16056", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine <=> H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446694", "l": "IRAK4 phosphorylates IRAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9754964", "l": "ADA deamidates RBV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62088", "l": "D-glucosamine 6-phosphate + NADP(+) = 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17362", "l": "3-oxo-3-ureidopropanoate + H2O => H(+) + malonate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381612", "l": "GLP1R binds GLP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617815", "l": "BBSome binds RAB3IP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60801", "l": "2-oxoglutarate + gibberellin A53 + O2 => CO2 + gibberellin A44 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5213466", "l": "RIPK3 is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27406", "l": "a ubiquinone + H2O + pyruvate => a ubiquinol + acetate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102561", "l": "D-ribose 2,5-bisphosphate 2-phosphohydrolase activity", "d": ["Catalysis of the reaction: H2O + D-ribofuranose 2,5-bisphosphate <=> hydrogenphosphate + D-ribofuranose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034535", "l": "1,2-dihydroxy-8-methylnaphthalene dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-8-methylnaphthalene + O2 = 2-hydroxy-8-methylchromene-2-carboxylate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604722", "l": "Activation of proMMP9 by proteases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28637", "l": "(+)-5-epi-aristolochene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65385", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O => (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0047935", "l": "glucose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,5-lactone + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10562", "l": "2,5-dioxopentanoate + NH4(+) => 4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32545", "l": "1,8-cineole + diphosphate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60653", "l": "an N-(acyl)-sphingosylphosphocholine => an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56432", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5681980", "l": "ATG12 binds ATG7 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48149", "l": "ganglioside GT1b (d18:1(4E)/18:0) + H2O => ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5251942", "l": "Hikeshi binds HSP70s:ATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63713", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793451", "l": "MLKL binds ITCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36334", "l": "ATP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265940", "l": "Rad51 assembly at the DNA-damage sites on the chromatin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37201", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705320", "l": "TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691167", "l": "CUL1, SKP1, FBXL5 bind (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42791", "l": "cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052594", "l": "aminoacetone:oxygen oxidoreductase(deaminating) activity", "d": ["Catalysis of the reaction: aminoacetone + H2O + O2 = methylglyoxal + NH3 + hydrogen peroxide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28931", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate = 4-carboxy-2-hydroxy-cis,cis-muconate", "d": []}, {"i": "EC:5.3.2.8", "l": "\"4-oxalomesaconate tautomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60187", "l": "ATP + D-glucose(out) + H2O <=> ADP + D-glucose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004974", "l": "leukotriene receptor activity", "d": ["Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990655", "l": "4 iron, 3 sulfur cluster binding", "d": ["Binding to a 4 iron, 3 sulfur (4Fe-3S) cluster, an uncommon iron-sulfur cluster with unique properties found in oxygen-tolerant Ni-Fe hydrogenases of various bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-167419", "l": "The receptor:G-protein complex releases GDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008345", "l": "RUNX2-P1 binds RUNX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005546", "l": "phosphatidylinositol-4,5-bisphosphate binding", "d": ["Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445079", "l": "Phosphorylation of L1 by ERK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23690", "l": "hypoxanthine + NH4(+) => adenine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36716", "l": "sphinganine + tetracosenoyl-CoA => an N-tetracosenoylsphinganine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029473", "l": "Branching and elongation of mother and daughter filaments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44262", "l": "4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40973", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72771", "l": "7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047624", "l": "adenosine-tetraphosphatase activity", "d": ["Catalysis of the reaction: adenosine 5'-tetraphosphate + H2O = ATP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047696", "l": "beta-adrenergic receptor kinase activity", "d": ["Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110158", "l": "TDG glycosylase mediated recognition and binding of a thymine opposite to a guanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28426", "l": "D-allulose 6-phosphate = keto-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70899", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = (2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65854", "l": "a 1-hydroxy-3-oxo steroid => a 3-oxo-Delta(1)-steroid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11286", "l": "H(+) + NADH + oxomalonate => hydroxymalonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432607", "l": "VRI replaces PDP1 as binder to Clk and cry genes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55172", "l": "2-oxoglutarate + hexanoyl-CoA + O2 = 2-hydroxyhexanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39779", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354097", "l": "Activation of Talin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55727", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62642", "l": "[mycoredoxin]-L-disulfide + an alcohol + H2O => [mycoredoxin]-L-dithiol + a hydroperoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17994", "l": "ATP + beta-alanine + gamma-L-glutamyl-L-cysteine => ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0015248", "l": "sterol transporter activity", "d": ["Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37514", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14356", "l": "3-dehydro-L-gulonate 6-phosphate + H(+) <=> CO2 + L-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15152", "l": "O2 + pyridoxine 5'-phosphate <=> H2O2 + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614591", "l": "Excess cysteine yields lanthionine and H2S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57349", "l": "3-hydroxy-4-methyl-L-kynurenine + H2O => 3-hydroxy-4-methylanthranilate + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2106615", "l": "Removal of siRNA passenger strand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607733", "l": "BCL10 binds CARD9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186780", "l": "Degradation of Ub-SMAD7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874080", "l": "SRC phosphorylates PTK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018768", "l": "RHOU auto-activates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170120", "l": "Translocation of Cdc25B to the cytoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29931", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP = ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45171", "l": "2 (E)-sinapoyl-CoA + spermidine <=> 2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015212", "l": "cytidine transmembrane transporter activity", "d": ["Enables the transfer of cytidine, cytosine riboside, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41533", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27943", "l": "(3R)-3-hydroxy-D-aspartate => NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990269", "l": "RNA polymerase II C-terminal domain phosphoserine binding", "d": ["Binding to phosphorylated serine residues in the C-terminal domain of RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372697", "l": "Crk binding to p130cas (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13727", "l": "CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate => acetyl-CoA + alpha-D-glucosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49324", "l": "(5R,6S)-5,6-epoxi-capsanthin = all-trans-capsorubin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0051575", "l": "5'-deoxyribose-5-phosphate lyase activity", "d": ["Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341072", "l": "SUMOylation of RARA with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940554", "l": "MMP2 cleaves OPTC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381727", "l": "RAP1A exchanges GDP for GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40149", "l": "CoA + eicosanoate + H(+) => eicosanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40570", "l": "AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 <=> A + dTDP-beta-L-evernitrose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102878", "l": "(+)-alpha-barbatene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-alpha-barbatene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856945", "l": "PP2A methylation by LCMT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404134", "l": "RBP4:atROL binds TTR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.62", "l": "\"magnolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.158", "l": "\"carotene epsilon-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3785684", "l": "Fibronectin degradation by CTSG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56590", "l": "an aldehyde + hydrogen cyanide => a monosubstituted aliphatic (S)-hydroxynitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66923", "l": "6-deoxy-6-sulfo-D-fructose + D-erythrose 4-phosphate <=> (2S)-3-sulfolactaldehyde + D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0050543", "l": "icosatetraenoic acid binding", "d": ["Binding to icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67807", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(20)-[histone H4] + O2 <=> CO2 + formaldehyde + L-lysyl(20)-[histone H4] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12428", "l": "2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH = benzene-1,2,4-triol + NAD(+)", "d": []}, {"i": "EC:1.6.5.7", "l": "\"2-hydroxy-1,4-benzoquinone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956676", "l": "YAP1 binds TP73 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781899", "l": "USP13 binds SIAH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38158", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (6E,10E)-geranyllinalool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024161", "l": "FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19978", "l": "3'-phosphoadenylyl sulfate + L-tyrosine methyl ester => adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43504", "l": "5-hydroxymethylfurfural + O2 = 2,5-diformylfuran + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018537", "l": "coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity", "d": ["Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme F420 + H+ = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5627775", "l": "Autophosphorylation of PAK1,2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047976", "l": "hamamelose kinase activity", "d": ["Catalysis of the reaction: D-hamamelose + ATP = D-hamamelose 2'-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54106", "l": "H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65873", "l": "1,17beta-dihydroxyandrostan-3-one + A => 17beta-hydroxyandrostan-1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112727", "l": "Serine phosphorylation of STATs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015647", "l": "peptidoglycan transmembrane transporter activity", "d": ["Enables the transfer of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483186", "l": "PC is converted to PS by PTDSS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2514831", "l": "Fibrillin-1 degradation by MMP14 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31154", "l": "H2O + L-selenocystathionine <=> 2-oxobutanoate + L-selenocysteine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237129", "l": "Acireductone is created (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434053", "l": "TRAF6 binds to p-IRAK2 complexed with activated TLR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60382", "l": "L-dehydroascorbate(in) => L-dehydroascorbate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399939", "l": "Autophosphorylation of PAK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59805", "l": "L-phenylalanine => D-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686430", "l": "MUS81 binds EME1, EME2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70047", "l": "2-oxoadipate + L-kynurenine = H2O + kynurenate + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192123", "l": "CYP27A1 27-hydroxylates CHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672817", "l": "Active MTORC1 binds the ULK1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69442", "l": "3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH => 3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29505", "l": "diphosphate + patchoulol => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27610", "l": "formate + H(+) = CO2 + H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34552", "l": "ATP + cob(II)yrinate c monoamide + H2O + L-glutamine => ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022141", "l": "Prolysyl oxidase activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30084", "l": "4 Cu(+) + 4 H(+) + O2 => 4 Cu(2+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032427", "l": "GBD domain binding", "d": ["Binding to a GTPase protein binding domain (GDB) domain. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033424", "l": "CCG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CCG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50563", "l": "acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26350", "l": "beta-L-galactose 1-phosphate + H2O => L-galactose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030487", "l": "inositol-4,5-bisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11204", "l": "apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin = AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]", "d": []}, {"i": "EC:6.3.4.10", "l": "\"biotin--[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38726", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69290", "l": "sulfate + sulforaphane => (Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0086080", "l": "protein binding involved in heterotypic cell-cell adhesion", "d": ["Binding to a protein or protein complex contributing to the adhesion of two different types of cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74076", "l": "H(+) + NADH + phylloquinone => NAD(+) + phylloquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75837", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + glutathione disulfide + H2O => (5S)-hydroperoxy-(6E,8Z)-octadecadienoate + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000514", "l": "3-sulfino-L-alanine: proton, glutamate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-sulfino-L-alanine (cysteinesulfinate) (out) + H+(in) + L-glutamate(in) = 3-sulfino-L-alanine(in) + H+(out) + L-glutamate(out)."]}, {"i": "RHEA:70967", "l": "3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in) = 3-sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17020", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA <=> (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426569", "l": "Interaction of DAP12 and IREM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021478", "l": "WWC1 (Kibra) gene expression is stimulated by NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12467", "l": "myo-inositol + UDP-alpha-D-galactose <=> alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44325", "l": "1-butyrylglycerol + H2O => butanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983150", "l": "Proteasomal cleavage of substrate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3240957", "l": "Formation of PRC2-EZH2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419166", "l": "GEFs activate RhoA,B,C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.n2", "l": "\"argonaute-2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68846", "l": "(Z)-alpha-bisabolene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16149", "l": "beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide", "d": []}, {"i": "EC:2.4.2.12", "l": "\"nicotinamide phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13659", "l": "acetate + H(+) + holo-[citrate lyase ACP] => acetyl-[citrate lyase ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5655483", "l": "USP1 autocleavage (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696947", "l": "USP47 deubiquitinates POLB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592278", "l": "Autocatalytic activation of proMMP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62772", "l": "N-acetyl-D-phenylalanine = N-acetyl-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40293", "l": "AMP + diphosphate + tetradecanedioyl-CoA => ATP + CoA + tetradecanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34796", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O => alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24979", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759141", "l": "AcK-NFE2L2 and MAFK bind NQO1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-532603", "l": "Nephrin mediated activation of N-WASP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809663", "l": "Formation of hair keratin fibres (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45853", "l": "Co(II)-factor III + H(+) + S-adenosyl-L-methionine => Co(II)-factor IV + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21172", "l": "L-idonate + NAD(+) = 5-dehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9772351", "l": "Disassembly of the Intron Lariat Spliceosome (new) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12929", "l": "2-oxoglutarate + acetyl-CoA + H2O = (2R)-homocitrate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.14", "l": "\"homocitrate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994169", "l": "F-actin capping protein binds to the barbed end of elongating F-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18828", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose <=> [(1->6)-alpha-D-glucosyl](n+1) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72686", "l": "cholate(out) <=> cholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042012", "l": "interleukin-16 receptor activity", "d": ["Combining with interleukin-16 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64423", "l": "H(+)(out) + L-alanyl-L-proline(out) <=> H(+)(in) + L-alanyl-L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52439", "l": "a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA <=> 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54309", "l": "pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28416", "l": "4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+) => gamma-L-glutamylputrescine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210285", "l": "Trans-homophilic interaction of PECAM-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.119", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54839", "l": "H(+) + heptan-2-one + NADPH + O2 <=> H2O + NADP(+) + pentyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008476", "l": "RUNX2 binds GSK3B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42552", "l": "uridine(31) in tRNA = pseudouridine(31) in tRNA", "d": []}, {"i": "EC:5.4.99.42", "l": "\"tRNA pseudouridine(31) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696268", "l": "RND3 binds effectors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56280", "l": "3'-L-prolyl-AMP + holo-[peptidyl-carrier protein] = AMP + L-prolyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141310", "l": "FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30506", "l": "H2O + N-acetyl-L-glutamate 5-semialdehyde <=> acetate + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58163", "l": "ent-copalyl diphosphate <=> diphosphate + dolabradiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9639286", "l": "RRAGC,D exchanges GTP for GDP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24559", "l": "5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) <=> 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15740", "l": "cyclopentanone + H(+) + NADPH + O2 <=> 5-valerolactone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047896", "l": "formaldehyde transketolase activity", "d": ["Catalysis of the reaction: D-xylulose 5-phosphate + formaldehyde = glyceraldehyde 3-phosphate + glycerone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29760", "l": "octanoate(in) => octanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44885", "l": "a cardiolipin + H2O => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432164", "l": "Ca2+ influx into the post-synaptic cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086223", "l": "Collagen type IX binds integrin alpha11beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38063", "l": "2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA = 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32428", "l": "(1R,4S)-isodihydrocarvone + A => (S)-carvone + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699574", "l": "FOXO3-dependent BCL2L11 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1980125", "l": "ITCH binds DTX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199456", "l": "PTEN dephosphorylates PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21468", "l": "dTDP-alpha-D-mycaminose + tylactone = 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.316", "l": "\"tylactone mycaminosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75569", "l": "11-O-acetylcyathatriol + CoA => acetyl-CoA + cyathatriol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48389", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2214324", "l": "Collagen type VII dimerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42814", "l": "cholesteryl octadecanoate + CoA => cholesterol + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21999", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA <=> a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983194", "l": "Kinesin-1 is a heterotetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28021", "l": "enterobactin + 3 H2O <=> 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22118", "l": "H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP => luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70462", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2 <=> a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174438", "l": "Formation of the Flap Intermediate on the C-strand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15071", "l": "chlorophyllide a + H2O => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40756", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate => 1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54532", "l": "H2O + N-(4-oxoglutaryl)-L-cysteinylglycine = 2-oxoglutarate + L-cysteinylglycine", "d": []}, {"i": "EC:3.5.1.128", "l": "\"deaminated glutathione amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53240", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] = cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52861", "l": "a short-chain fatty acid + ATP + CoA => a short-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68103", "l": "NAD(+) + xylitol <=> H(+) + L-xylulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62448", "l": "holo-[peptidyl-carrier protein] + L-glutamyl-5'-AMP = AMP + H(+) + L-glutamyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58689", "l": "NADH + O2 + rifamycin SV => H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2995388", "l": "PP2A dephosphorylates BANF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71876", "l": "2 Na(+)(out) + taurocholate(out) => 2 Na(+)(in) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69546", "l": "6-O-adenylylstreptidine + diphosphate => ATP + streptidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781832", "l": "Defective MPI does not  isomerize Fru6P to Man6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849085", "l": "ARHGAP35 binds RHOA:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9706837", "l": "AR binds AR antagonists (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625904", "l": "Hypochlorous acid (HOCL) reacts with Lys residue to form Lys-monochloramine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12612", "l": "mercaptopurine + S-adenosyl-L-methionine <=> 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28144", "l": "streptothricin D acid => H2O + streptothricin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534040", "l": "Unknown NAT N-acylates Gly in GNAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851908", "l": "Activated MET binds GAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030156", "l": "benzodiazepine receptor binding", "d": ["Binding to a peripheral benzodiazepine receptor (PBR)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033429", "l": "CGU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CGU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63588", "l": "prunetin + UDP-alpha-D-glucuronate = prunetin-4'-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047423", "l": "N-methylhydantoinase (ATP-hydrolyzing) activity", "d": ["Catalysis of the reaction: N-methylhydantoin + ATP + 2 H2O = N-carbamoylsarcosine + ADP + 3 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676596", "l": "TRAF3 binds BAFFR:BAFF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-377640", "l": "Autophosphorylation of SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55743", "l": "H2O + oleuropein <=> D-glucose + oleuropein aglycone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48204", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA = (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0031409", "l": "pigment binding", "d": ["Binding to a pigment, a general or particular coloring matter in living organisms, e.g. melanin."]}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0019957", "l": "C-C chemokine binding", "d": ["Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10857", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose => a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64384", "l": "H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine = alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69622", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60168", "l": "a fatty acid + ATP = a fatty acyl monophosphate + ADP", "d": []}, {"i": "EC:2.7.2.18", "l": "\"fatty acid kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379387", "l": "COMT transfers Met to DA to form 3MT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-434989", "l": "SEMA7A binds to PLXNC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140536", "l": "nuclear receptor corepressor activity", "d": ["A transcription corepressor activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Nuclear receptor corepressors often act by altering chromatin structure and modifications. For example, one class of transcription nuclear receptor corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664588", "l": "ERBB2 KD mutants trans-autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004656", "l": "procollagen-proline 4-dioxygenase activity", "d": ["Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18896", "l": "a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5678327", "l": "MIOX oxidises Ins to GlcA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66238", "l": "H2O2 + IC-asc-DeltaC9-CoA => IC-asc-C9-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24308", "l": "25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.282", "l": "\"quinate/shikimate dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18694", "l": "a penicillin + H2O => 6-aminopenicillanate + a carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53622", "l": "(-)-spiroviolene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59211", "l": "ATP + H(+) + octadecanoate <=> diphosphate + octadecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28293", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (5S,9S,10S)-drim-7-en-11-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14180", "l": "(R)-amygdalin + H2O <=> (R)-prunasin + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.29", "l": "\"picornain 2A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23839", "l": "D-methionine + pyruvate <=> 4-methylsulfanyl-2-oxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22997", "l": "H2O2 + L-ascorbate => 2 H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2130706", "l": "MHC class II antigen processing (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41810", "l": "(2E)-butenoyl-[ACP] + H2O => (3R)-hydroxybutanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52288", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73901", "l": "ADP + gamma-L-glutamylcadaverine + H(+) + phosphate => ATP + cadaverine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69152", "l": "Removal of remaining Flap (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10238", "l": "H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP => trans-2-coumarate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75605", "l": "plasmodiophorol A => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.177", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17938", "l": "dihydroxyacetone phosphate => methylglyoxal + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12072", "l": "an (S)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2545203", "l": "Deacetylation of cleaved cohesin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110322", "l": "Formation of Pol zeta complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928591", "l": "EPH:EFN tetramers oligomerise (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60356", "l": "H2O + N-octanoylanthranilate = anthranilate + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46903", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) <=> a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0046812", "l": "host cell surface binding", "d": ["Binding to the surface of a host cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19345", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate = (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951644", "l": "Release of mature NEDD8 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848873", "l": "PTK6 phosphorylates ARAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.262", "l": "\"soyasapogenol glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-481044", "l": "Surface deployment of platelet alpha granule membrane components (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610720", "l": "PKA phosphorylates GLI3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52590", "l": "7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH => choloyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52434", "l": "2 NH4(+) + pyruvate => (R)-2,3-diaminopropanoate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43345", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26122", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418925", "l": "ADORA2A,B bind Ade-Rib (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14297", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose", "d": []}, {"i": "EC:3.2.1.46", "l": "\"galactosylceramidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31301", "l": "2 H(+) + NADH + perillate => H2O + NAD(+) + perillyl aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611277", "l": "P2RY12 binds P2RY12 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3318415", "l": "ATF2 acetylates histone H2B, H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23735", "l": "(R)-5-diphosphomevalonate + ATP <=> ADP + CO2 + isopentenyl diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190682", "l": "Connexin synthesis (generic) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6794347", "l": "Homer1,2,3 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944261", "l": "Association of procollagen type XIII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804741", "l": "MDM2 forms homo- or heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74734", "l": "Re-integration of insulin receptor into plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12556", "l": "6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)", "d": []}, {"i": "EC:3.1.1.31", "l": "\"6-phosphogluconolactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801776", "l": "REG3A binds bacterial phospholipids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5668714", "l": "RAC1:GTP binds NOX1 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5250930", "l": "B-WICH recruits histone acetyltransferases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13442", "l": "H2O + L-cysteate => H(+) + NH4(+) + pyruvate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186780", "l": "PI3-kinase binds to the active receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29473", "l": "D-ribose + phosphate => D-ribose 5-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-990489", "l": "Kinesin-13 is a dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49126", "l": "H2O + NADP(+) + protoviolaceinate => H(+) + NADPH + O2 + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167076", "l": "2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11157", "l": "H2O + L-valine + NADP(+) => 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351936", "l": "Caspase-mediated cleavage of claspin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052683", "l": "(Z)-gamma-bisabolene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015546", "l": "sulfathiazole transmembrane transporter activity", "d": ["Enables the transfer of sulfathiazole from one side of a membrane to the other. Sulfathiazole is an antibacterial agent of the sulfonamide group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71659", "l": "a D-glucoside + 2 Fe(III)-[cytochrome c] = a 3-dehydro-D-glucoside + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}, {"i": "EC:1.1.2.11", "l": "\"glucoside 3-dehydrogenase (cytochrome c)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050015", "l": "kievitone hydratase activity", "d": ["Catalysis of the reaction: kievitone hydrate = H2O + H+ + kievitone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24558", "l": "5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH => 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71242", "l": "2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH <=> 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19728", "l": "H(+) + UDP-alpha-D-galacturonate <=> CO2 + UDP-beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247960", "l": "Activation of p38 MAPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66598", "l": "2 dopamine => O2 + 2 tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58212", "l": "ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] = dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11476", "l": "glycerol 1-phosphate + H2O = glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16452", "l": "acetyl-CoA + kanamycin B <=> CoA + H(+) + N(6')-acetylkanamycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26139", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23482", "l": "dimethylmaleate => 2-methylene-3-methylsuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140870", "l": "RNA polymerase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of RNA polymerase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607751", "l": "TRAF6 oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728697", "l": "GNAT3 exchanges GDP for GTP in TAS1R2:TAS1R3:sweet compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49104", "l": "Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine = 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29120", "l": "a ubiquinol + nitrate => a ubiquinone + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69051", "l": "H2O + hexano-6-lactone <=> 6-hydroxyhexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167429", "l": "The receptor:G-protein complex  binds GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807008", "l": "PTPRJ dephosphorylates MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050409", "l": "indolylacetylinositol arabinosyltransferase activity", "d": ["Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-L-arabinose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13255", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4-trisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.23", "l": "\"DNA-formamidopyrimidine glycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602473", "l": "Autocatalytic activation of MMP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65552", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = an N-acyl-sphingoid base + lactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396029", "l": "Latent TGF-beta-3 binds integrins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5099899", "l": "WNT5A binds FZD4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865482", "l": "KMT2A (MLL) binds RUNX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210290", "l": "Interaction of PECAM-1 and SHIP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25747", "l": "L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76031", "l": "2 H2O2 => O2 + 2 H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052907", "l": "23S rRNA (adenine(1618)-N(6))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052881", "l": "4-hydroxyphenylacetate 3-monooxygenase activity", "d": ["Catalysis of the reaction: (4-hydroxyphenyl)acetate + FADH(2) + O2 = 3,4-dihydroxyphenylacetate + FAD + H+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50126", "l": "8-oxoresolvin D1 + H(+) + NADH => NAD(+) + resolvin D1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0034189", "l": "very-low-density lipoprotein particle binding", "d": ["Binding to a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28997", "l": "H(+)(in) + L-threonine(out) => H(+)(out) + L-threonine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16659", "l": "D-ribose + hypoxanthine => H2O + inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75948", "l": "L-arginine + taurine => L-ornithine + taurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19710", "l": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622415", "l": "RIP2 binds NEMO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46777", "l": "a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389083", "l": "Autophosphorylation of PDGF alpha receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37900", "l": "2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 => 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29459", "l": "beta-alanine(in) + H(+)(in) = beta-alanine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050336", "l": "thioethanolamine S-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + cysteamine = S-acetylcysteamine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607058", "l": "Activated protein C:PROCR binds F2R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602466", "l": "Activation of MT-MMPs by FURIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11019", "l": "allantoate + H2O <=> (S)-ureidoglycolate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664879", "l": "ATM:PEX5 binds ATM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35938", "l": "2 ATP + L-proline + L-tryptophan <=> 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848178", "l": "STAT3 stimulates SOCS3 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57851", "l": "2-oxoglutarate + O2 + scopoletin <=> CO2 + fraxetin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69171", "l": "H2O + NAD(+) + spermine monoaldehyde <=> 2 H(+) + N-(2-carboxyethyl)spermidine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874979", "l": "ACBD3 binds GOLGB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58534", "l": "akuammicine + formate + H(+) => 15alpha-stemmadenine intermediate I + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28185", "l": "(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate <=> (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65708", "l": "alpha-D-mannose 1-phosphate + GDP-beta-L-galactose = beta-L-galactose 1-phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34500", "l": "1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] => H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21729", "l": "GDP-alpha-D-mannose + H2O + 2 NAD(+) => GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944214", "l": "Association of procollagen type I (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34979", "l": "H(+)(in) = H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53776", "l": "3-sulfanylpropanoate + O2 = 3-sulfinopropanoate + H(+)", "d": []}, {"i": "EC:1.13.11.91", "l": "\"3-mercaptopropionate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36417", "l": "diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41082", "l": "1-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993769", "l": "Transfer of SUMO3 from E1 to UBE2I (UBC9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18399", "l": "AMP + diphosphate + L-glutamyl-tRNA(Glx) => ATP + L-glutamate + tRNA(Glx)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759892", "l": "Expression of BMP4 in lateral plate mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675947", "l": "TNFSF18 binds TNFRSF18 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.481603666032214", "identifiers": [{"i": "GO:0004634", "l": "phosphopyruvate hydratase activity", "d": ["Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332236", "l": "CBL neddylates TGFBR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4331327", "l": "E2F1 binds PMAIP1 (NOXA) promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50680", "l": "H2O + N-terminal L-glutaminyl-[protein] = N-terminal L-glutamyl-[protein] + NH4(+)", "d": []}, {"i": "EC:3.5.1.122", "l": "\"protein N-terminal glutamine amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69916", "l": "guanosine(out) + 2 Na(+)(out) => guanosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-874087", "l": "SGT1 binds HSP90 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59767", "l": "L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] + octadecanoyl-CoA <=> CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034558", "l": "technetium (VII) reductase activity", "d": ["Catalysis of the reaction: pertechnetate ion + 3/2 H2 = technetium (IV) oxide + H2O + OH-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909552", "l": "Phosphorylation of STAT1 at Ser727 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62390", "l": "[(1->2)-beta-D-glucosyl](n-2) + sophorose => [(1->2)-beta-D-glucosyl](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17273", "l": "(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) = 4-hydroxyphenylacetate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.53", "l": "\"4-hydroxyphenylacetaldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047348", "l": "glycerol-3-phosphate cytidylyltransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + CTP = CDP-glycerol + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50840", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015083", "l": "aluminum ion transmembrane transporter activity", "d": ["Enables the transfer of aluminum (Al) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52886", "l": "2 H(+) + 2 NADPH + nitrobenzene => H2O + N-phenylhydroxylamine + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20940", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0015174", "l": "basic amino acid transmembrane transporter activity", "d": ["Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52260", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide c = a bacteriochlorophyllide e + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68864", "l": "H2O + isomaltose = alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32740", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632677", "l": "PTCH is internalized (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53340", "l": "5,6-dihydrouridine(20) in tRNA + NAD(+) = H(+) + NADH + uridine(20) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64170", "l": "(2S)-2-aminobutanoate + formaldehyde => 2-ethyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047110", "l": "phenylglyoxylate dehydrogenase (acylating) activity", "d": ["Catalysis of the reaction: CoA + NAD+ + phenylglyoxylate = benzoyl-CoA + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56361", "l": "13-deoxycarminomycin + H(+) + NADPH + O2 => 13-dihydrocarminomycin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74006", "l": "A + peniprequinolone <=> AH2 + yaequinolone E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112434", "l": "Formation of DSIF complex  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71066", "l": "L-arginine(in) + L-histidine(out) <=> L-arginine(out) + L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009029", "l": "tetraacyldisaccharide 4'-kinase activity", "d": ["Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + ATP = ADP + 2 H+ + lipid IV(a)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28606", "l": "L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.38", "l": "\"valine N-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15801", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609689", "l": "HCMV Binds to the Host Cell via heparan sulfate proteoglycans (HSPG) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177930", "l": "GAB1 phosphorylation by EGFR kinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72725", "l": "UDP-alpha-D-xylose(out) + UMP(in) => UDP-alpha-D-xylose(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30258", "l": "2 a ubiquinol + O2 <=> 2 a ubiquinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36398", "l": "7-dehydrocholesterol + NADP(+) <=> 7-dehydrodesmosterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641134", "l": "SMURF2 binds AXIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52429", "l": "12-oxo-leukotriene B4 + H(+) + NADH => 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33958", "l": "DIBOA + UDP-alpha-D-glucose <=> DIBOA beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1470009", "l": "Phosphorylation of STATs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420980", "l": "Activation of Ca permeable AMPA receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55235", "l": "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 Fe(III)-[cytochrome b561] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-398185", "l": "LARG binds plexin B1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034041", "l": "ABC-type sterol transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sterol(in) = ADP + phosphate + sterol(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60946", "l": "H(+) + isorhamnetin + S-adenosyl-L-homocysteine => quercetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051750", "l": "delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity", "d": ["Catalysis of the reaction: a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50388", "l": "5a,11a-dehydrotetracycline + H(+) + NADPH + O2 = 5a,11a-dehydrooxytetracycline + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.234", "l": "\"12-dehydrotetracycline 5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42757", "l": "cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40352", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32966", "l": "2-oxoglutaramate + H2O <=> 2-oxoglutarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61901", "l": "AH2 + betaenone C => A + betaenone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53083", "l": "4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.5", "l": "\"thrombin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664983", "l": "Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877178", "l": "ATP binds to P2X7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64394", "l": "a dipeptide(in) + H(+)(in) => a dipeptide(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706336", "l": "Active FLT3 binds to SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199046", "l": "Ligands bind L-selectin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050438", "l": "2-ethylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxobutanate + acetyl-CoA + H2O = (R)-2-ethylmalate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15722", "l": "glycine + H2O + NAD(+) => glyoxylate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20898", "l": "ADP + H(+) + phosphate + urea-1-carboxylate => ATP + hydrogencarbonate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36961", "l": "D-ribose + NAD(+) => D-ribono-1,4-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680388", "l": "CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17406", "l": "N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine => H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55898", "l": "5-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097162", "l": "MADS box domain binding", "d": ["Binding to a MADS box domain, a protein domain that encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. MADS-domain proteins are generally transcription factors. The length of the MADS-box is in the range of 168 to 180 base pairs."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201629", "l": "Caspase-mediated cleavage of Tau (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13758", "l": "(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose => (Z)-desulfoglucotropeolin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15394", "l": "(2S,6S)-2,6-diaminoheptanedioate => meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008685", "l": "2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity", "d": ["Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39350", "l": "(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH <=> (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11323", "l": "UDP-beta-L-arabinopyranose <=> UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693356", "l": "CEMIP hydrolyses HA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58745", "l": "H2O + N(7)-methyl-GTP => diphosphate + H(+) + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18083", "l": "diphosphate + pentalenene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848335", "l": "IL37 binds  IL18R1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592240", "l": "Formation of NRF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62274", "l": "8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine => 4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62776", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034786", "l": "9-fluorenone-3,4-dioxygenase activity", "d": ["Catalysis of the reaction: 9-fluorenone + O2 + 2 H+ + 2 e- = 1-hydro-1,1a-dihydroxy-9-fluorenone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51072", "l": "a phenol + an aryl sulfate = a phenol + an aryl sulfate", "d": []}, {"i": "EC:2.8.2.22", "l": "\"aryl-sulfate sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34557", "l": "a 2-oxocarboxylate + H(+) + NADH => a (2S)-2-hydroxycarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784765", "l": "p-Y705-STAT3 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449077", "l": "Interleukin-16 is secreted (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21197", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine => L-methionine + tetrahydropteroyltri-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53919", "l": "an acyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-acyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-937034", "l": "IRAK1 phosphorylates Pellino (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18223", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate => 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39621", "l": "(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+) => (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8867344", "l": "OMA1 hydrolyses OPA1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198314", "l": "DAG stimulates protein kinase C-delta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0016842", "l": "amidine-lyase activity", "d": ["Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate."]}, {"i": "EC:4.3.2.-", "l": "\"Lyases acting on amides, amidines, etc\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67852", "l": "FMNH2 + O2 = FMN-N(5)-peroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15492", "l": "adenosine + H2O + 2 O2 <=> 9-riburonosyladenine + H(+) + 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69418", "l": "H2O + hypothiocyanous acid => H(+) + H2O2 + thiocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.3.7", "l": "\"tetrahydrocannabinolic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17312", "l": "a phenyl acetate + H2O <=> a phenol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416698", "l": "SEMA5A binds to PLXNB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29419", "l": "H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801666", "l": "PLK2 phosphorylates CENPJ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012209", "l": "Estrogen-responsive KPNA2 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928591", "l": "EPH:EFN tetramers oligomerise (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20078", "l": "guanosine(18) in tRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990400", "l": "mitochondrial ribosomal large subunit rRNA binding", "d": ["Binding to a mitochondrial large ribosomal subunit RNA (LSU rRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70412", "l": "4-hydroxyphenylacetyl-CoA + H2O => 4-hydroxyphenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15698", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20415", "l": "glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine => glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25684", "l": "2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase] => L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671702", "l": "AP1G2 binds HGS and CHMP2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015265", "l": "urea channel activity", "d": ["Enables the facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37489", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46263", "l": "an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38616", "l": "cyclic ADP-beta-D-ribose + H2O => ADP-D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30671", "l": "H2O + N,N'-diacetylchitobiose = 2 N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29575", "l": "L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43379", "l": "5'-deoxyinosine + phosphate <=> 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001601", "l": "peptide YY receptor activity", "d": ["Combining with gut peptide YY to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784861", "l": "HSPG binds LPL dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446634", "l": "IRAK4 is activated by autophosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41098", "l": "H2O + sphing-4-enine-phosphocholine <=> H(+) + phosphocholine + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451033", "l": "(S)-Malate <=> Fumarate + H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983138", "l": "Transport of MHC heterotrimer to ER exit site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68679", "l": "3'-phosphoadenylyl sulfate + estrone 3-O-(beta-D-glucuronate) <=> adenosine 3',5'-bisphosphate + estrone 3-O-(3-sulfo-beta-D-glucuronate) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12828", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine <=> [thioredoxin]-dithiol + H(+) + phosphate + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390846", "l": "D2D3,4 bind to DA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396371", "l": "NOTCH1 Coactivator Complex binds MYC promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419389", "l": "LPA-binding receptors bind LPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047387", "l": "serine-ethanolaminephosphate phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + serine phosphoethanolamine = H+ + phosphoethanolamine + serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980039", "l": "NOTCH1 binds DLL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855232", "l": "RELN:VLDLR binds DAB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70666", "l": "4-hydroxy-L-proline(in) + H(+)(in) <=> 4-hydroxy-L-proline(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14106", "l": "L-proline + NAD(+) => 1-pyrroline-5-carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77077", "l": "Capping complex formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5228992", "l": "ROCK1,ROCK2 are activated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351876", "l": "Caspase-mediated cleavage of occludin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72647", "l": "Cap-bound mRNA is activated by helicases  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18529", "l": "3-methylbutanol + NAD(+) = 3-methylbutanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55545", "l": "L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29768", "l": "ATP + D-methionine(out) + H2O => ADP + D-methionine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52674", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate => 2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72883", "l": "2 3-phenylpyruvate + 2 ATP = 2 AMP + 2 diphosphate + H(+) + polyporic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852552", "l": "MST1R autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64154", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51890", "l": "2,3,5,6-tetrachloro-1,4-benzoquinone + NADH => 2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106408", "l": "diadenylate cyclase activity", "d": ["Catalysis of the reaction: 2 ATP = 3',3'-c-di-AMP + 2 diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661230", "l": "MT1A binds arsenic (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20500", "l": "a 2-arylethylamine + acetyl-CoA <=> an N-acetyl-2-arylethylamine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617828", "l": "TRIP11:IFT20 dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694689", "l": "Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35413", "l": "an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside] + CoA + H(+) => (E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69613", "l": "beta-D-glucose + D-glucose => H2O + kojibiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54477", "l": "1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190265", "l": "FGFR4 binds to FGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5213466", "l": "RIPK3 is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853496", "l": "SCF:FBXL7 binds AURKA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113429", "l": "Elongating transcript encounters a lesion in the template (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12901", "l": "D-arginine + H2O = D-ornithine + urea", "d": []}, {"i": "EC:3.5.3.10", "l": "\"D-arginase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71376", "l": "2 Na(+)(out) + testosterone 17-sulfate(out) => 2 Na(+)(in) + testosterone 17-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52503", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977371", "l": "Factor I inactivates Factor H-boundC3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187382", "l": "Degradation of ubiquitinated SMAD3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23909", "l": "H(+) + 2 methylcob(III)alamin-[methionine synthase] + NADP(+) + 2 S-adenosyl-L-homocysteine => 2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55822", "l": "5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine => a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847534", "l": "RAB43 hydrolyses GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65780", "l": "2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980125", "l": "ITCH binds DTX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14999", "l": "deoxylimononate D-ring-lactone + H(+) => deoxylimonoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483089", "l": "PE is converted to PS by PTDSS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28712", "l": "H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) => H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46497", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in) => N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64594", "l": "a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37626", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70158", "l": "6alpha-hydroxy-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 28-norcastasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31085", "l": "L-alanine + N-acetyl-D-muramate => H2O + N-acetyl-D-muramoyl-L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19028", "l": "H2O + L-aspartate + O2 <=> H2O2 + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.3", "l": "\"uridine phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56710", "l": "16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070287", "l": "ferritin receptor activity", "d": ["Combining with ferritin, and delivering ferritin into the cell via endocytosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17549", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.16", "l": "\"methylene-fatty-acyl-phospholipid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27782", "l": "4-hydroxybenzoate + all-trans-octaprenyl diphosphate = 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11496", "l": "O-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate + H(+)", "d": []}, {"i": "EC:2.5.1.53", "l": "\"uracilylalanine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.210", "l": "\"4-methyl-5-nitrocatechol 5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31391", "l": "15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) = all-trans-4,4'-diapolycopene + 4 FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0016653", "l": "oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein."]}, {"i": "EC:1.6.2.-", "l": "\"With a heme protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14114", "l": "a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O => a 3'-end 2'-deoxyribonucleotide-DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-383190", "l": "HCO3- transport through ion channel (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46095", "l": "(25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18639", "l": "H(+) + NADPH => H2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38418", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411367", "l": "TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68071", "l": "a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909724", "l": "Recruitment of IFNAR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43150", "l": "H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine => adenosine(9) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13435", "l": "2'-deoxyuridine + NH4(+) => 2'-deoxycytidine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28175", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => colneleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42939", "l": "S-adenosyl-L-methionine + uridine(32) in tRNA <=> 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879762", "l": "Expression of DBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990970", "l": "trans-activation response element binding", "d": ["Binding to a trans-activation response (TAR) element, a hairpin RNA structure located at the 5' end of all HIV-1 transcripts, and which is required for trans-activation of a viral promoter."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18643", "l": "a menaquinol => a menaquinone + H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45880", "l": "3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641206", "l": "RSPOs bind LGRs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35725", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + CoA => hexadecanoyl-CoA + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65785", "l": "2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018611", "l": "toluate dioxygenase activity", "d": ["Catalysis of the reaction: methylbenzoate + NADH + O2 + H+ = NAD+ + 1,2-dihydroxymethylcyclohexa-3,5-dienecarboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.69", "l": "\"SARS coronavirus main proteinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029473", "l": "Branching and elongation of mother and daughter filaments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937419", "l": "CBR3 reduces DOX to DOXOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27778", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) = 2-all-trans-octaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60636", "l": "N-(dodecanoyl)-sphing-4-enine-1-phosphocholine = choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22442", "l": "H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP => UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18350", "l": "ATP + L-aspartate + tRNA(Asx) => AMP + diphosphate + L-aspartyl-tRNA(Asx)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1454928", "l": "ABCG4 may mediate cholesterol efflux (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038149", "l": "C-C motif chemokine 2 receptor activity", "d": ["Combining with the C-C motif chemokine 2 (CCL2) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19972", "l": "hydroxylamine + O2 <=> H(+) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696323", "l": "CNRs bind CNR agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042931", "l": "enterobactin transmembrane transporter activity", "d": ["Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28935", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = oxaloacetate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74726", "l": "Dissociation of insulin from insulin receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45145", "l": "3-(methylsulfanyl)acryloyl-CoA + 2 H2O => acetaldehyde + CO2 + CoA + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58070", "l": "acetaldehyde + vanillin => (E)-isoeugenol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73269", "l": "H(+)(in) + L-methionine(out) => H(+)(out) + L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61030", "l": "S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein] => itaconate + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6783880", "l": "PIPOX oxidises PPCA to P6C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32865", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59333", "l": "1'-hydroxy-gamma-carotene + A => 1'-hydroxytorulene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9674093", "l": "PDGFRs bind type I TKI (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70284", "l": "H2O + N-acetylputrescine + O2 => 4-acetamidobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374173", "l": "AGT(34-41) binds to AGTR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64929", "l": "dADP + H2O => dAMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47508", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADH = isolithocholate + NAD(+)", "d": []}, {"i": "EC:1.1.1.391", "l": "\"3beta-hydroxycholanate 3-dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209792", "l": "N-acetylation of serotonin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72860", "l": "3',3',3'-c-tri-AMP + H2O => A[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54412", "l": "a 3-oxo-5beta-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70881", "l": "L-glutamine(out) + L-threonine(in) + Na(+)(in) => L-glutamine(in) + L-threonine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60225", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18106", "l": "ATP + Ca(2+)(in) + H2O => ADP + Ca(2+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392752", "l": "Phosphorylation of L1 by CK-II (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844620", "l": "dsDNA:AIM2 clusters bind ASC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25477", "l": "(2E,6E)-farnesyl diphosphate => alpha-himachalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71753", "l": "2-oxoglutarate(in) + glutarate(out) => 2-oxoglutarate(out) + glutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47659", "l": "acetyl-CoA + L-methionine sulfone <=> CoA + H(+) + N-acetyl-L-methionine sulfone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53308", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14006", "l": "H2O + L,L-cystathionine => 2-oxobutanoate + L-cysteine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25396", "l": "(9Z,12Z)-octadecadienoate + O2 => (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30992", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14400", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) <=> (4Z)-2-oxohept-4-enedioate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45598", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54330", "l": "hexadecan-1-ol + holo-[ACP] + 2 NADP(+) => 2 H(+) + hexadecanoyl-[ACP] + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4088134", "l": "PLK1 phosphorylates FOXM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443439", "l": "c-Src binds Raf1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10141", "l": "NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74778", "l": "kaempferide + S-adenosyl-L-methionine <=> 7,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22063", "l": "(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050195", "l": "phosphoribokinase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + ATP = D-ribose 1,5-diphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12217", "l": "9H-fluoren-9-ol + NAD(+) => 9H-fluoren-9-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173725", "l": "C9 binds C5b:C6:C7:C8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63856", "l": "O2 + tetradecanoate = (2R)-2-hydroperoxytetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102285", "l": "1-deoxy-11-oxopentalenate oxygenase activity", "d": ["Catalysis of the reaction: 1-deoxy-11-oxopentalenate + O2 + NADPH + H+ = pentalenolactone D + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2995334", "l": "COX15 transforms heme O to heme A (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61031", "l": "itaconate + L-cysteinyl-[protein] <=> S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68451", "l": "13-cis-lycopene + O2 <=> (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 13-cis-10'-apo-lycopenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24660", "l": "H(+) + L-arginine + NADPH + O2 = H2O + N(omega)-hydroxy-L-arginine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850831", "l": "KLK5 cleaves and activates KLK8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35268", "l": "ethanol(in) => ethanol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41028", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70249", "l": "beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + H(+) + UDP => N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12625", "l": "(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose = D-glucose + sinapoyl (S)-malate", "d": []}, {"i": "EC:2.3.1.92", "l": "\"sinapoylglucose--malate O-sinapoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27616", "l": "di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate => (2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635854", "l": "GLI2,3 are degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009042", "l": "valine-pyruvate transaminase activity", "d": ["Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350058", "l": "Formation of CSL NCOR corepressor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45429", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine => H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11854", "l": "adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate => phosphate + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37399", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20290", "l": "acetyl-CoA + H2O => acetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614544", "l": "Sulfite is oxidized to sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55951", "l": "A + D-alanine + H2O <=> AH2 + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16827", "l": "ADP + H(+) + UMP => ATP + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102495", "l": "GA5 3beta-hydroxylase activity", "d": ["Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate <=> gibberellin A3 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28241", "l": "calycosin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38434", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O <=> (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1222376", "l": "NOX2 generates superoxide from oxygen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36563", "l": "GDP-beta-L-colitose + NADP(+) = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45590", "l": "a long-chain fatty acyl-[ACP] + AMP + diphosphate => a long-chain fatty acid + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19562", "l": "androst-4-ene-3,17-dione + H(+) + NADPH + O2 => H2O + NADP(+) + testololactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981621", "l": "Neuroglobin:oxygen dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700156", "l": "Active ALK dimer binds IRS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0045510", "l": "interleukin-24 binding", "d": ["Binding to interleukin-24."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-168947", "l": "Ligand binds to TLR10 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372529", "l": "Release of acetylcholine at the synapse (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080132", "l": "fatty acid alpha-hydroxylase activity", "d": ["Catalysis of the conversion of a fatty acid to an alpha-hydroxylated fatty acid. A hydroxyl group is added to the second carbon, counted from the carboxyl end, of a fatty acid chain."]}, {"i": "REACT:R-HSA-5693761", "l": "FA2H hydroxylates CERA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043899", "l": "phosphoserine:homoserine phosphotransferase activity", "d": ["Catalysis of the transfer of a phosphoryl group from phosphoserine to homoserine to form phosphohomoserine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097434", "l": "succinate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + H+(out) = succinate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.96", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15586", "l": "15-cis-phytoene + 4 A => 4 AH2 + all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381109", "l": "IRE1 binds IRE1 forming dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15879", "l": "D-glutamate + pyridoxal 5'-phosphate => 2-oxoglutarate + pyridoxamine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654163", "l": "Activated FGFR4 binds PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949580", "l": "F1Fo ATP synthase dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44825", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol => a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625375", "l": "FOXO3,FOXO4 bind STK11 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641205", "l": "RSPO:LGR binds ZNRF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64819", "l": "5-aminolevulinate(in) <=> 5-aminolevulinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759158", "l": "SQSTM1 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15226", "l": "alpha-D-glucose 1-phosphate + dTTP + H(+) => diphosphate + dTDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66816", "l": "2 Na(+)(in) + tetrahydroxoborate(in) = 2 Na(+)(out) + tetrahydroxoborate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42945", "l": "cytidine(40) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66063", "l": "2-oxohexanoate + L-kynurenine <=> H2O + kynurenate + L-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351478", "l": "Association of gamma-H2AX with MCPH1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37852", "l": "13-deoxydaunorubicin + H(+) + NADPH + O2 => 13-dihydrodaunorubicin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804762", "l": "TP53 forms homotetramers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944233", "l": "Association of procollagen type XIX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380200", "l": "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69173", "l": "Joining of adjacent Okazaki fragments (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69116", "l": "Formation of Okazaki fragments (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848758", "l": "PTK6 phosphorylates AKT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23070", "l": "6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+) => 6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42974", "l": "a cardiolipin + ethanolamine => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18788", "l": "A + gibberellin A12 aldehyde + H2O <=> AH2 + gibberellin A12 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33886", "l": "2-deoxy-scyllo-inosamine + NAD(+) <=> 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38071", "l": "2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37876", "l": "aklanonate + S-adenosyl-L-methionine => methyl aklanonate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450975", "l": "isocitrate <=> citrate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71289", "l": "chloride(in) + L-arginine(in) + 2 Na(+)(in) => chloride(out) + L-arginine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58948", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050100", "l": "methylitaconate delta-isomerase activity", "d": ["Catalysis of the reaction: 2-methylene-3-methylsuccinate = dimethylmaleate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65205", "l": "(3R)-3-hydroxybutanoyl-CoA + H2O => (R)-3-hydroxybutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37204", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45842", "l": "3-oxodecanoyl-CoA + H(+) + NADPH => (3R)-3-hydroxydecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35334", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17581", "l": "an N-carbamoyl-L-alpha-amino acid + 2 H(+) + H2O = an L-alpha-amino acid + CO2 + NH4(+)", "d": []}, {"i": "EC:3.5.1.87", "l": "\"N-carbamoyl-L-amino-acid hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51641", "l": "(9Z,12Z)-octadecadienoate + O2 => (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351901", "l": "Caspase-mediated cleavage of MST3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180597", "l": "Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008789", "l": "altronate dehydratase activity", "d": ["Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20115", "l": "beta-D-glucose 6-phosphate => beta-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706344", "l": "FLT3 phosphorylates GRB10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755777", "l": "SARS-CoV-2 M, N bind to PDPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46941", "l": "AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] => ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50142", "l": "(14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11543", "l": "an N-acyl-D-mannosamine + NAD(+) <=> an N-acyl-D-mannosaminolactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56012", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16596", "l": "3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine <=> 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43221", "l": "guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849102", "l": "SRMS phosphorylates PTK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749215", "l": "MCM8 binds CDC6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60957", "l": "17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose => (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63619", "l": "prunetin + UDP-alpha-D-glucuronate <=> H(+) + prunetin-C(8)-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66183", "l": "ATP + bilirubin-glucuronoside(in) + H2O <=> ADP + bilirubin-glucuronoside(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31956", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-398184", "l": "LARG activation by G alpha 12/13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57301", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O => a 2'-deoxyguanosine in DNA + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49175", "l": "8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine <=> 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635859", "l": "GLI:SUFU dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936563", "l": "ISGylation of DDX58 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187382", "l": "Degradation of ubiquitinated SMAD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164505", "l": "Synthesis of full-length duplex viral DNA with a discontinuous plus strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033457", "l": "GAU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GAU codon."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051989", "l": "coproporphyrinogen dehydrogenase activity", "d": ["Catalysis of the reaction: coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10945", "l": "H2O + psi-UMP => phosphate + pseudouridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12991", "l": "a dolichyl phosphate + D-mannose + H(+) => a dolichyl beta-D-mannosyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140685", "l": "FAD-dependent histone H3K9me/H3K9me2 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37533", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938853", "l": "CDK6 binds RUNX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418172", "l": "F2R binds ARRB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67533", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034986", "l": "iron chaperone activity", "d": ["Directly binding to and delivering iron ions to a target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49514", "l": "phosphinomethylisomalate => 2-(phosphinatomethylidene)butanedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12485", "l": "a ribonucleoside 5'-phosphate + H2O => a ribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.100", "l": "\"(R)-amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209536", "l": "IkB is ubiquitinated and degraded (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52824", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 = (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62223", "l": "phyllostine <=> neopatulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38853", "l": "H2O + tetracenomycin F1 => H(+) + tetracenomycin F2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58804", "l": "5'-pApG-3' + H2O = 5'-ApG-3' + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56207", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] <=> 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008684", "l": "2-oxopent-4-enoate hydratase activity", "d": ["Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40087", "l": "22-hydroxydocosanoate + NAD(+) = 22-oxodocosanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33845", "l": "sphinganine + tetracosanoate => H2O + N-tetracosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420131", "l": "The PACAP receptor binds PACAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65605", "l": "(4R)-hydroxysphinganine + eicosanoyl-CoA => CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0031890", "l": "vasoactive intestinal polypeptide receptor binding", "d": ["Binding to a vasoactive intestinal polypeptide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28190", "l": "2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50478", "l": "CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] => anthraniloyl-CoA + L-cysteinyl-[PqsD protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41822", "l": "3-oxohexanoyl-[ACP] + CO2 + holo-[ACP] => butanoyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44642", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + ADP => a 2'-deoxyribonucleoside 5'-diphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74817", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38968", "l": "an N-acylsphing-4-enine(in) + ATP + H2O => ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59621", "l": "H2O + N(2)-(4-aminobutanoyl)-L-lysine => 4-aminobutanoate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33408", "l": "ATP + glycine + H(+) => diphosphate + glycyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10369", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39206", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADPH <=> NADP(+) + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29173", "l": "a ubiquinone + 2 H(+) + 2 superoxide => a ubiquinol + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10803", "l": "diphosphate + XMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0160009", "l": "histone decrotonylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] = (2E)-2-butenoate + L-lysyl-[histone]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10127", "l": "H(+) + NADPH + O2 + phenylacetone <=> benzyl acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0000906", "l": "6,7-dimethyl-8-ribityllumazine synthase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29487", "l": "(2E,6E)-farnesyl diphosphate = cis-muurola-3,5-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74752", "l": "dodecapentaneoyl-[polyketide synthase] + fumagillol => holo-[polyketide synthase] + prefumagillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42571", "l": "2,3-dihydroxy-p-cumate + O2 <=> 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432054", "l": "Aquaporin-1 passively transports water out of cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23947", "l": "(E)-coniferol + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-coniferol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11096", "l": "NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-381091", "l": "IRE1 dimer autophosphorylates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70984", "l": "glycine(out) + n H(+)(in) => glycine(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47759", "l": "guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170846", "l": "TGFBR2 recruits TGFBR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68231", "l": "glycine(in) + Na(+)(in) <=> glycine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607734", "l": "PKC-delta translocates to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0072542", "l": "protein phosphatase activator activity", "d": ["Binds to and increases the activity of a protein phosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44832", "l": "(R)-carnitine + tetradecanoyl-CoA = CoA + O-tetradecanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13409", "l": "7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH", "d": []}, {"i": "EC:1.7.1.13", "l": "\"preQ1 synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28733", "l": "H(+)(in) + L-leucine(out) => H(+)(out) + L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16281", "l": "ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.88", "l": "\"dihydrostreptomycin-6-phosphate 3'alpha-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031249", "l": "denatured protein binding", "d": ["Binding to a denatured protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634884", "l": "NPAS4 binds CDK5 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19939", "l": "H(+) + S-adenosyl-L-homocysteine + sarcosine => glycine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64829", "l": "3-hydroxybenzyl alcohol + acetyl-CoA => 3-hydroxy-benzyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004655", "l": "porphobilinogen synthase activity", "d": ["Catalysis of the reaction: 2 5-aminolevulinate = 2 H2O + H+ + porphobilinogen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462003", "l": "HNP1-4 are stored in primary neutrophil granules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432411", "l": "SLMB binds phosphorylated cytosolic PER, facilitating its ubiquitination (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73018", "l": "D-leucine(in) <=> D-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72697", "l": "Start codon recognition (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10570", "l": "H(+) + luteolin 7-O-beta-D-glucuronide + UDP => luteolin + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59858", "l": "methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] + trimethylamine => Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75880", "l": "Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) + L-proline betaine => methyl-Co(III)-[quaternary-amine-specific corrinoid protein] + N-methyl-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605723", "l": "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374919", "l": "Noradrenaline clearance from the synaptic cleft (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340214", "l": "CYGB binds O2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45176", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32126", "l": "citrate(in) + H(+)(in) <=> citrate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990482", "l": "sphingolipid alpha-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucuronate + inositol phosphorylceramide (IPC) = UDP + GlcA-IPC."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17638", "l": "squalene => hop-22(29)-ene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58830", "l": "9R,10R-dihydroxyoctadecanoate => (9S,10R)-epoxy-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31883", "l": "(S)-2,3-epoxysqualene = delta-amyrin", "d": []}, {"i": "EC:5.4.99.55", "l": "\"delta-amyrin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033969", "l": "gamma-glutamyl-gamma-aminobutyrate hydrolase activity", "d": ["Catalysis of the reaction: 4-(L-gamma-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35496", "l": "H2O + N-(4-aminobenzoyl)-L-glutamate => 4-aminobenzoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41313", "l": "1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74893", "l": "CO2(in) => CO2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40009", "l": "(+)-copalol + diphosphate => (+)-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49080", "l": "dibenzothiophene 5-oxide + FMNH2 + O2 = dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034013", "l": "aliphatic aldoxime dehydratase activity", "d": ["Catalysis of the reaction: an aliphatic aldoxime = an aliphatic nitrile + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15662", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside => an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50737", "l": "a quinone + 2 H(+) + hydrogen sulfide + sulfite => a quinol + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30370", "l": "adenosylcob(III)alamin 5'-phosphate + H2O <=> adenosylcob(III)alamin + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050290", "l": "sphingomyelin phosphodiesterase D activity", "d": ["Catalysis of the reaction: H2O + sphingomyelin = ceramide 1-phosphate + choline + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31864", "l": "(S)-2,3-epoxysqualene => friedelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205136", "l": "GTP-bound RAC contributes to JNK activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381608", "l": "cAMP activates EPAC2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592314", "l": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693347", "l": "CRYM reduces P2C to PPCA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66241", "l": "ATP + CoA + IC-asc-C9 => AMP + diphosphate + IC-asc-C9-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035851", "l": "Krueppel-associated box domain binding", "d": ["Binding to a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37026", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5334794", "l": "FABPs bind LCFAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102224", "l": "GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose hydrolase/2-epimerase activity", "d": ["Catalysis of the reaction: GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19332", "l": "nuatigenin + UDP-alpha-D-glucose <=> H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021050", "l": "HSBP1 oligomer binds ESRs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69614", "l": "H2O + kojibiose <=> beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085992", "l": "SUMOylation of DAXX with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53539", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O <=> (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58014", "l": "2 5'-hydroxy-diadenylate 2',3'-cylic phosphate => cyclic tetraadenylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74743", "l": "kaempferol + S-adenosyl-L-methionine = 3-O-methylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0034601", "l": "oxoglutarate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + CoA + NAD(P)+ = succinyl-CoA + CO2 + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56048", "l": "daidzein + UDP-alpha-D-glucose = daidzein 7-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30259", "l": "2 a menaquinol + O2 = 2 a menaquinone + 2 H2O", "d": []}, {"i": "EC:7.1.1.5", "l": "\"menaquinol oxidase (H(+)-transporting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34042", "l": "2-oxoglutarate + neamine <=> 6'-oxoparomamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983194", "l": "Kinesin-1 is a heterotetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102045", "l": "3-chlorobenzoate-3,4-oxygenase activity", "d": ["Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32446", "l": "all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856951", "l": "PP2A demethylation by PPME1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904767", "l": "octanoic acid binding", "d": ["Binding to octanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805811", "l": "Release of SEPT4 from mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4837364", "l": "Secretion of SOD3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41153", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+) => 1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50976", "l": "prostaglandin D2(out) = prostaglandin D2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55181", "l": "2-oxoglutarate + 3-methylnonanoyl-CoA + O2 => 2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14491", "l": "a nucleoside 2'-phosphate + H(+) => a nucleoside 2',3'-cyclic phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44635", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + O2 <=> 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46360", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}, {"i": "EC:1.14.18.4", "l": "\"phosphatidylcholine 12-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218828", "l": "PTK2/SRC-1 phosphorylates BCAR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9645598", "l": "RRAGC,D hydrolyzes GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52146", "l": "(R)-2-(phosphonomethyl)malate + CoA + H(+) => 3-phosphonopyruvate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683774", "l": "p-T68-CHEK2 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002466", "l": "Formation of allysine by LOX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19170", "l": "L-serine => NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73408", "l": "(S,S)-tartrate(in) + sulfate(out) => (S,S)-tartrate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050092", "l": "meso-tartrate dehydrogenase activity", "d": ["Catalysis of the reaction: (2R,3S)-tartrate + NAD+ = dihydroxyfumarate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72180", "l": "Cleavage of mRNA at the 3'-end (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-706479", "l": "TAK1 is activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953013", "l": "E2F7 binds E2F8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785213", "l": "LIPC dimer binds heparin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626220", "l": "C2CD3 binds the mother centriole (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74317", "l": "O-isobutanoyl-(R)-carnitine(out) => O-isobutanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23088", "l": "ATP + O-alkylglycerone = 1-O-alkylglycerone 3-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.84", "l": "\"alkylglycerone kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75103", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 32-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003948", "l": "N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity", "d": ["Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55205", "l": "5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine => 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938034", "l": "NR4A3 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983147", "l": "Release of E3 from polyubiquitinated substrate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46135", "l": "cholesterol + H(+) + NADPH + O2 <=> 25-hydroxycholesterol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0099604", "l": "ligand-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909552", "l": "Phosphorylation of STAT1 at Ser727 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985943", "l": "p-Y701-STAT1 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017108", "l": "5'-flap endonuclease activity", "d": ["Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798748", "l": "Exocytosis of secretory granule lumen proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062068", "l": "chloroplast photosystem II binding", "d": ["Binding to a chloroplast photosystem II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24498", "l": "CoA + vindoline => 4-O-deacetylvindoline + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28664", "l": "H2O + melibiose => D-galactose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684261", "l": "MAP3K8 is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865276", "l": "PDGF-AB clevage by Furin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29580", "l": "Fe(2+)(in) + H(+)(in) => Fe(2+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050061", "l": "long-chain-aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+. A long-chain aldehyde is one with more than 12 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56115", "l": "2-all-trans-nonaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54659", "l": "linalool <=> (2E)-geraniol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4411402", "l": "Activation of NLK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0008525", "l": "phosphatidylcholine transporter activity", "d": ["Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72703", "l": "UDP-alpha-D-galactose(in) + UMP(out) = UDP-alpha-D-galactose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606564", "l": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46133", "l": "cholesterol + H(+) + NADPH + O2 => 25-hydroxycholesterol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662613", "l": "MT3 exchanges zinc for copper (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.194933448780617", "identifiers": [{"i": "GO:0016410", "l": "N-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule."]}, {"i": "REACT:R-HSA-177160", "l": "phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391377", "l": "Luteinizing hormone receptor can bind LH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62818", "l": "2 dinapinone E + 2 H2O => 4 monapinone E + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51844", "l": "(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000010", "l": "trans-hexaprenyltranstransferase activity", "d": ["Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27418", "l": "2 Fe(III)-[cytochrome] + H2O + nicotinate => 6-hydroxynicotinate + 2 Fe(II)-[cytochrome] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102715", "l": "gibberellin A17,oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A17 + 2-oxoglutarate + O2 <=> gibberellin A28 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696465", "l": "USP45 deubiquitinates ERCC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371567", "l": "DBC1 is phosphorylated by ATM/ART (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159796", "l": "Furin cleaves pro-factor IX to factor IX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41008", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin => 6-linalyl-2-O,3-dimethylflaviolin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683355", "l": "Defective ABCB6 does not transport porphyrin from cytosol into mitochondria matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72903", "l": "butyrolactone II + dimethylallyl diphosphate = butyrolactone I + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682010", "l": "ATG10:ATG12 binds ATG5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66888", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018638", "l": "toluene 4-monooxygenase activity", "d": ["Catalysis of the reaction: toluene + 1/2 O2 = 4-hydroxytoluene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172405", "l": "Collagen type XXIII ectodomain shedding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661432", "l": "BIL binds ALB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38810", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197690", "l": "Detachment of WASP/WAVE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63625", "l": "hexadecanoyl-AMP + holo-[ACP] => AMP + H(+) + hexadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41652", "l": "aclacinomycin S + dTDP-2-deoxy-beta-L-fucose = 2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30483", "l": "N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804276", "l": "ATM phosphorylates TTC5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15249", "l": "3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose = 1-O-galloyl-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55256", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23718", "l": "(2E)-dodecenoyl-CoA => (3Z)-dodecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52929", "l": "3',3'-c-di-GMP + 2 H2O => 2 GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34445", "l": "CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+) => acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39977", "l": "2-oxobutanoate + NH4(+) => 2-iminobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204824", "l": "Interaction of Tie2 and Ang4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68550", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + xanthotoxol => O2 + psoralen + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12351", "l": "(S)-muconolactone <=> (4,5-dihydro-5-oxofuran-2-yl)-acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50732", "l": "4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] = (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035486", "l": "cytosine/cytosine mispair binding", "d": ["Binding to a double-stranded DNA region containing a C/C mispair."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050549", "l": "cyclohexyl-isocyanide hydratase activity", "d": ["Catalysis of the reaction: N-cyclohexylformamide + H+ = cyclohexyl isocyanide + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004477", "l": "methenyltetrahydrofolate cyclohydrolase activity", "d": ["Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001621", "l": "G protein-coupled ADP receptor activity", "d": ["Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64440", "l": "glycylglycyl-L-proline(out) + H(+)(out) = glycylglycyl-L-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029453", "l": "Phosphorylation of VAV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047741", "l": "cetraxate benzylesterase activity", "d": ["Catalysis of the reaction: benzyl cetraxate + H2O = benzyl alcohol + cetraxate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166869", "l": "TRAF6 binds MEKK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174121", "l": "Association of Securin with Cdc20:APC/C complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664867", "l": "NBR1 binds MAP1LC3B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53157", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031962", "l": "nuclear mineralocorticoid receptor binding", "d": ["Binding to a nuclear mineralocorticoid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16252", "l": "alpha-D-glucose 6-phosphate <=> beta-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098697", "l": "ryanodine-sensitive calcium-release channel activity involved in regulation of postsynaptic cytosolic calcium levels", "d": ["Any ryanodine-sensitive calcium-release channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64939", "l": "dGTP + H2O <=> dGDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090079", "l": "GLB1 hydrolyses linker chain(2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664270", "l": "Recruitment of PLCgamma to membrane due to FCGR3A effect (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52240", "l": "2 H2O + 2 Mn(2+) + O2 = 4 H(+) + 2 MnO2", "d": []}, {"i": "EC:1.16.3.3", "l": "\"manganese oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74653", "l": "CDP + H(+) + N-acetyl-D-glucosamine 6-phosphate => CTP + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44824", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64854", "l": "CoA + octyl benzoate => benzoyl-CoA + octan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018528", "l": "iminodiacetate dehydrogenase activity", "d": ["Catalysis of the reaction: iminodiacetate + OH- = H+ + 2 e- + glyoxylate + glycine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003921", "l": "GMP synthase activity", "d": ["Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3797202", "l": "AP-1 stimulates transcription of IGFBP7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9793485", "l": "PRKN polyubiquitinates RIPK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34767", "l": "5,10-methenyltetrahydrofolate + H2O = (6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70590", "l": "H2O + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) <=> acetate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798474", "l": "S100A8:S100A9 binds Zn2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54926", "l": "3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP] => (7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31670", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23633", "l": "D-threo-isocitrate + NAD(+) => 2-oxoglutarate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18024", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) <=> CMP + ganglioside GD1a (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30820", "l": "allantoin + H2O => allantoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13834", "l": "L-arginine + pyruvate => 5-guanidino-2-oxopentanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46949", "l": "GTP + S-adenosyl-L-methionine => N(7)-methyl-GTP + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51204", "l": "6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182990", "l": "Sprouty sequesters CBL away from active EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046962", "l": "sodium-transporting ATPase activity, rotational mechanism", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out), by a rotational mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34865", "l": "3-hydroxyadipyl-CoA => (Z)-2,3-didehydroadipyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8942302", "l": "MMP13 cleaves OPTC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050607", "l": "mycothiol-dependent formaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60311", "l": "L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12570", "l": "4-nitrocatechol + H2O + NAD(+) => 4-nitrophenol + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31338", "l": "CTP + H(+) + Mo-molybdopterin <=> diphosphate + Mo-molybdopterin cytosine dinucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56895", "l": "H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose <=> NADP(+) + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60005", "l": "(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O => (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167087", "l": "Limited elongation of the HIV-1 transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391935", "l": "DP1 receptor can bind PGD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873927", "l": "Release of STAT1 dimer from active receptor unit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22458", "l": "sarcosine + urea => creatine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228811", "l": "NFKBIA variant is not phosphorylated within IkBA:NF-kappaB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187506", "l": "Translocation of p27 to the nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001161", "l": "intronic transcription regulatory region sequence-specific DNA binding", "d": ["Binding to an intronic DNA sequence that regulates the transcription of the transcript it is contained within."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202212", "l": "Recruitment of PLC-gamma1 to LAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41530", "l": "NAD(+) + octanoyl-[ACP] => (2E)-octenoyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38855", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55638", "l": "AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate => ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603784", "l": "PEX19:class I PMP binds PEX3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805122", "l": "AURKB binds TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851436", "l": "CFHR dimers bind C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791144", "l": "Expression of EXTL3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205649", "l": "p62 links damaged mitochondria to LC3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28098", "l": "ATP + GDP = AMP + guanosine 3',5'-bis(diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937814", "l": "RUNX3 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61250", "l": "3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+) => H2O + L-tyrosine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69116", "l": "Formation of Okazaki fragments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004817", "l": "cysteine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25630", "l": "myricetin + S-adenosyl-L-methionine => H(+) + laricitrin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26386", "l": "all-trans-8'-apo-beta-carotenal + O2 => (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.190", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9692738", "l": "HRH2 binds HRH2 antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036139", "l": "peptidyl-histidine dioxygenase activity", "d": ["Catalysis of the reaction: peptidyl L-histidine + 2-oxoglutarate + O2 = peptidyl hydroxy-L-histidine + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865774", "l": "TTLLs polyglutamylate tubulin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62873", "l": "(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2 => H2O + NADP(+) + semiviriditoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371435", "l": "Constitutive phosphorylation by GSK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373745", "l": "SDK1 homophillic interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250972", "l": "botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46214", "l": "4-amino-5-aminomethyl-2-methylpyrimidine + formate => H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14668", "l": "guanine + H(+) + H2O <=> NH4(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52263", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide c <=> a bacteriochlorophyllide e + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379887", "l": "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71811", "l": "3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L-thyronine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202245", "l": "Phosphorylation of TBSMs in LAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762333", "l": "ANGPTL4 binds to CDH11v (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15833", "l": "(S)-4-hydroxymandelate + H(+) + O2 = 4-hydroxybenzaldehyde + CO2 + H2O2", "d": []}, {"i": "EC:1.1.3.19", "l": "\"4-hydroxymandelate oxidase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46387", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24123", "l": "H(+) + leukotriene E4 + NADPH + O2 <=> 20-hydroxy-leukotriene E4 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51814", "l": "AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674022", "l": "BRAP autoubiquitinates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13769", "l": "glycerol + NAD(+) = dihydroxyacetone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.6", "l": "\"glycerol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0004124", "l": "cysteine synthase activity", "d": ["Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71707", "l": "H(+)(out) + L-phenylalanyl-L-phenylalanine(out) = H(+)(in) + L-phenylalanyl-L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10280", "l": "1,7-dimethylxanthine + S-adenosyl-L-methionine = caffeine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55263", "l": "2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672948", "l": "MARK3 phosphorylates KSR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10522", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42842", "l": "2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+) => acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51112", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25372", "l": "(2S)-2-amino-4-deoxychorismate + FMN => 3-(1-carboxyvinyloxy)anthranilate + FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806423", "l": "TP53 stimulates DDB2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635102", "l": "GPR161 is internalized (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856951", "l": "PP2A demethylation by PPME1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388832", "l": "PI3K binds CD28 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54406", "l": "2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61244", "l": "H2O + L-tryptophan + O2 = H2O2 + indole-3-pyruvate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36317", "l": "CoA + hexadecan-1-ol + 2 NADP(+) => 2 H(+) + hexadecanoyl-CoA + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53950", "l": "ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate => ATP + holo-[BtrI ACP] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74183", "l": "S-adenosyl-L-methionine + taxifolin = H(+) + S-adenosyl-L-homocysteine + taxifolin 4'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40101", "l": "1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67624", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59544", "l": "N,N'-diacetylchitobiose + O2 = H2O2 + N,N'-diacetylchitobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42118", "l": "17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH => 5alpha-androstane-3alpha,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0030275", "l": "LRR domain binding", "d": ["Binding to a LRR domain (leucine rich repeats) of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11923", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin <=> (6R)-L-erythro-6,7-dihydrobiopterin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69384", "l": "(R)-carnitine + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) = (3R)-4-(dimethylamino)-3-hydroxybutanoate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein]", "d": []}, {"i": "EC:2.1.1.383", "l": "\"L-carnitine--corrinoid protein Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41487", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41120", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10011", "l": "[protein]-dithiol + a hydroperoxide <=> [protein]-disulfide + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51656", "l": "keto-D-tagaturonate = keto-D-fructuronate", "d": []}, {"i": "EC:5.1.2.7", "l": "\"tagaturonate epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.3.-", "l": "\"Sialyltransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050289", "l": "spermidine dehydrogenase activity", "d": ["Catalysis of the reaction: spermidine + acceptor + H2O = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296326", "l": "HCAR1 binds LACT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168882", "l": "Association of NP into rafts (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34268", "l": "acetyl-CoA + fumigaclavine B => CoA + fumigaclavine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56533", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102563", "l": "aurachin C monooxygenase activity", "d": ["Catalysis of the reaction: aurachin C + O2 + H+ + NAD(P)H <=> aurachin C epoxide + H2O + NAD(P)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27305", "l": "7-chloro-L-tryptophan + O2 <=> 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611030", "l": "GluN1 (GRIN1) binds to ACTN2 at postsynaptic density (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47708", "l": "ADP + alpha-D-glucose 1-phosphate + H(+) = ADP-alpha-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020513", "l": "GRIN2B gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047846", "l": "deoxynucleotide 3'-phosphatase activity", "d": ["Catalysis of the reaction: a deoxynucleoside 3'-phosphate + H2O = a deoxynucleoside + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619376", "l": "CAMK1 binds calmodulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15775", "l": "ADP + dihydroxyacetone phosphate + H(+) => ATP + dihydroxyacetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48313", "l": "benzoyl-CoA + H(+) + NADPH + O2 => 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193997", "l": "CYP11B1 oxidises 11DCORT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21238", "l": "2,3-dihydroxybenzoate + NADP(+) + NH4(+) => anthranilate + 2 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72066", "l": "glycoursodeoxycholate(out) + 2 Na(+)(out) <=> glycoursodeoxycholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47241", "l": "H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614591", "l": "Excess cysteine yields lanthionine and H2S (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13917", "l": "(-)-menthol + NADP(+) = (1R,4S)-menthone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.207", "l": "\"(-)-menthol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809680", "l": "MTMR12 binds MTM1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38351", "l": "(R)-3-phenyllactate + NAD(+) = 3-phenylpyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13069", "l": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine", "d": []}, {"i": "EC:2.7.1.82", "l": "\"ethanolamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036397", "l": "formate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: formate + a quinone = CO2 + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66537", "l": "A + cholest-4,6-dien-3-one + H2O => 25-hydroxycholest-4,6-dien-3-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388811", "l": "CD28 homodimer binds B7-1 homodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53599", "l": "1-octadecanoyl-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024361", "l": "Expression of ABCG1 regulated by NR1H2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874083", "l": "p-Y397-PTK2 binds SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156678", "l": "Activation of Cdc25C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102502", "l": "ADP-glucose-starch glucosyltransferase activity", "d": ["Catalysis of the reaction: ADP alpha-D-glucoside + n a 1,4-alpha-D-glucan = ADP + n alpha-amylose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11591", "l": "A + H2O + isoquinoline <=> AH2 + isoquinolin-1(2H)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43139", "l": "guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75330", "l": "chloride(out) + D-tryptophan(out) + 2 Na(+)(out) <=> chloride(in) + D-tryptophan(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.5", "l": "\"hexose oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66935", "l": "(E)-4-coumaroyl-CoA + 5-hydroxyanthranilate <=> avenanthramide A + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63292", "l": "N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730862", "l": "Autophosphorylation of LYN kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28135", "l": "(2S)-hesperidin + H2O => (2S)-hesperetin + rutinose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0015296", "l": "monoatomic anion:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69087", "l": "acrolein + H2O + NAD(+) <=> acrylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391942", "l": "IP receptor can bind prostacyclin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69894", "l": "Na(+)(out) + thymidine(out) <=> Na(+)(in) + thymidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13555", "l": "ADP + alpha-D-galactose 1-phosphate + H(+) => alpha-D-galactose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13107", "l": "glycerol + phosphate => glycerol 2-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19049", "l": "(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine + GDP + H(+)", "d": []}, {"i": "EC:2.7.1.81", "l": "\"hydroxylysine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6805205", "l": "GPR35 binds kynurenic acid (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665708", "l": "ERBB2 TMD/JMD mutants do not bind pertuzumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30777", "l": "H2O2 + NH4(+) + pyridoxal => H2O + O2 + pyridoxamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10097", "l": "a fatty acyl-[ACP] + S-adenosyl-L-methionine => an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418925", "l": "ADORA2A,B bind Ade-Rib (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196964", "l": "RFK:Mg2+ phosphorylates RIB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52125", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67621", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine => a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388811", "l": "CD28 homodimer binds B7-1 homodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50510", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein] => acetyl-CoA + N-terminal L-valyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19241", "l": "ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] = ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15335", "l": "H(+) + N-carbamoyl-2-oxoglycine + NADPH => (S)-ureidoglycolate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30334", "l": "all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004314", "l": "[acyl-carrier-protein] S-malonyltransferase activity", "d": ["Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30471", "l": "(2Z,6Z)-farnesyl diphosphate = (1S,5S,6S)-alpha-bergamotene + diphosphate", "d": []}, {"i": "EC:4.2.3.54", "l": "\"(-)-endo-alpha-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964619", "l": "PAK1 binds ARHGEF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382058", "l": "Nck binds to the active PDGF receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57511", "l": "H2O + NADP(+) + staphylopine <=> (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9016751", "l": "FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41586", "l": "4-O-dimethylallyl-L-tyrosine + diphosphate => dimethylallyl diphosphate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16601", "l": "L-aspartate = fumarate + NH4(+)", "d": []}, {"i": "EC:4.3.1.1", "l": "\"aspartate ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61145", "l": "myricetin + UDP-beta-L-rhamnose => H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24955", "l": "1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O <=> ADP + H(+) + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690873", "l": "ACO1 binds 4Fe-4S (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37478", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16990", "l": "1D-myo-inositol hexakisphosphate + H2O => 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50484", "l": "acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203973", "l": "Vesicle budding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37966", "l": "galactitol + NAD(+) <=> D-galactose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3772430", "l": "CTNNBIP1 binds beta-catenin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001515", "l": "opioid peptide activity", "d": ["Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53478", "l": "(6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690461", "l": "FKBP1A binds tacrolimus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805811", "l": "Release of SEPT4 from mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14469", "l": "2-aminomuconate 6-semialdehyde + H2O + NAD(+) = (2Z,4E)-2-aminomuconate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.32", "l": "\"aminomuconate-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34925", "l": "nitrate(out) => nitrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371435", "l": "Constitutive phosphorylation by GSK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62333", "l": "ADP + ATP => adenosine 3'-diphosphate,5'-diphosphate + AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018643", "l": "carbon disulfide oxygenase activity", "d": ["Catalysis of the reaction: carbon disulfide + NADH + H+ + O2 = [S] + H2O + NAD+ + carbonyl sulfide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036169", "l": "3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity", "d": ["Catalysis of the reaction: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid -> 2-methoxy-6-decaprenylphenol + CO2."]}, {"i": "REACT:R-HSA-2162195", "l": "MHDB is decarboxylated to DMPhOH by MHDB decarboxylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55559", "l": "a hydroperoxyeicosatetraenoate <=> an oxoeicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41249", "l": "9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10017", "l": "H2O + O-sinapoylcholine => (E)-sinapate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605051", "l": "Expression of PCK1 regulated by NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70156", "l": "6alpha-hydroxy-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] => 28-norcastasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56687", "l": "dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40573", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67613", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964274", "l": "G alpha (12) binds BTK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48340", "l": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.2", "l": "\"medium-chain acyl-CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51606", "l": "4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174235", "l": "Association of Emi1 with Cdc20 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40474", "l": "(2S)-methylpentadecanoyl-CoA + O2 <=> 2-methyl-(2E)-pentadecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69116", "l": "Formation of Okazaki fragments (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45715", "l": "3-dehydrocarnityl-CoA + CoA <=> acetyl-CoA + N,N,N-trimethylglycyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45380", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.7.2", "l": "\"7-hydroxymethyl chlorophyll a reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250930", "l": "B-WICH recruits histone acetyltransferases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0098531", "l": "ligand-activated transcription factor activity", "d": ["A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427514", "l": "eNoSC deacetylates histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22623", "l": "H(+) + L-tryptophan + O2 <=> 3-indoleglycolaldehyde + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64554", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112265", "l": "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67991", "l": "N-acetyl-L-glutamine <=> N-acetyl-D-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102448", "l": "rhamnetin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> ombuin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404142", "l": "atROL binds RBP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52995", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine <=> [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977363", "l": "Factor H binds to C3bBb (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66563", "l": "(R)-noradrenaline + L-glutaminyl-[protein] <=> 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400434", "l": "FFAR1 binds fatty acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0016670", "l": "oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen."]}, {"i": "EC:1.8.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18770", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate => 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19024", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine <=> an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47544", "l": "trans-4-hydroxy-L-proline betaine = cis-4-hydroxy-D-proline betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948641", "l": "miR-106 microRNAs bind VAPA mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36495", "l": "alpha-D-glucose + ATP = ADP + alpha-D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50391", "l": "5a,11a-dehydrotetracycline + H(+) + NADPH + O2 <=> 5a,11a-dehydrooxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874979", "l": "ACBD3 binds GOLGB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852552", "l": "MST1R autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102934", "l": "costunolide synthase activity", "d": ["Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-oate + O2 + NADPH + 2 H+ = costunolide + 2 H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31688", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371591", "l": "Trimerization of cytosolic HSF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183067", "l": "Localization of CBL:GRB2 to the membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033821", "l": "DNA beta-glucosyltransferase activity", "d": ["Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050043", "l": "lactate racemase activity", "d": ["Catalysis of the reaction: (S)-lactate = (R)-lactate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64537", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18406", "l": "H2O + L-alanine + NAD(+) => H(+) + NADH + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.20", "l": "\"aminopeptidase Ey\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381309", "l": "PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624956", "l": "PDE6D binds INPP5E (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54057", "l": "(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-hedycaryol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629483", "l": "NEIL3 cleaves spiroiminodihydantoin from damaged telomeric DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15384", "l": "O2 + quercetin <=> 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20622", "l": "ATP + H2O + Zn(2+)(in) => ADP + H(+) + phosphate + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43735", "l": "a triacyl-sn-glycerol + H2O <=> 1,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70786", "l": "H(+)(out) + L-aspartate(in) + L-glutamate(out) <=> H(+)(in) + L-aspartate(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41418", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+) => 1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49774", "l": "CoA + H(+) + N-hexacosanoylglycine => glycine + hexacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64750", "l": "2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate => H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37912", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210805", "l": "Removal of miRNA passenger strand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26002", "l": "D-arabinitol 1-phosphate + NAD(+) = D-xylulose 5-phosphate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.301", "l": "\"D-arabitol-phosphate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59880", "l": "4-hydroxyphenylacetate + FMNH2 + O2 = 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57250", "l": "dGTP + glycolate + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33662", "l": "H(+) + N-tetracosanoylsphinganine + NADPH + O2 <=> H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38451", "l": "hydrogen sulfide + NADP(+) + n sulfur = NADPH + (n+1) sulfur", "d": []}, {"i": "EC:1.8.1.19", "l": "\"sulfide dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37800", "l": "2 H(+) + 2 NADH + O2 => 2 H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15675", "l": "acetoacetate + CoA + H(+) => acetoacetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69570", "l": "4-amino-4-deoxychorismate + L-glutamate + NH4(+) => (2S)-2-amino-4-deoxychorismate + H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692376", "l": "BCL2 binds BCL2 antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.39", "l": "\"plasmepsin II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876789", "l": "CARNMT1 methylates CARN to Anserine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34193", "l": "(2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+) => (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3304394", "l": "Activated TGFBR1 cannot phosphorylate SMAD2 and SMAD3 Phosphorylation Motif Mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201630", "l": "Caspase-mediated cleavage of Acinus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687585", "l": "Defective SLC34A2 does not cotransport HPO4(2-), 3Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675431", "l": "PP2A dephosphorylates RAF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22936", "l": "H2O + N-acetyl-D-glucosamine 6-phosphate = acetate + D-glucosamine 6-phosphate", "d": []}, {"i": "EC:3.5.1.25", "l": "\"N-acetylglucosamine-6-phosphate deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:1990043", "l": "5' deoxyribonuclease (pyrimidine dimer) activity", "d": ["Catalysis of the endonucleolytic cleavage immediately 5' to pyrimidine dimers to products with 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54662", "l": "an aromatic aldehyde + hydrogen cyanide => an aromatic (S)-hydroxynitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20286", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate => alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72643", "l": "1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine = 1,6-dimethoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48020", "l": "globoside Gb3Cer + H2O = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73109", "l": "apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine => acacetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20818", "l": "3-oxoglycyrrhetinate + H(+) + NADPH => 3alpha-hydroxyglycyrrhetinate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112436", "l": "Formation of Elongin complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451366", "l": "Activation of p38MAPK by DSCAM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45526", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin alpha-subunit] => phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9017491", "l": "RHOJ GEFs activate RHOJ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804276", "l": "ATM phosphorylates TTC5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68960", "l": "DNA polymerase epsilon binds at the origin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73338", "l": "ATP + beta-alanine + tryptamine <=> AMP + beta-alanyl-tryptamine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9793451", "l": "MLKL binds ITCH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139918", "l": "Phosphorylation of BIM by JNK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683774", "l": "p-T68-CHEK2 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784402", "l": "Spontaneous hydrolysis of 1-pyrroline-3-hydroxy-5-carboxylate to 4-OH-L-glutamate semialdehyde (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59171", "l": "ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate <=> AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26228", "l": "abieta-7,13-dien-18-al + H2O + NAD(+) <=> abieta-7,13-dien-18-oate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61079", "l": "(-)-minovincinine + acetyl-CoA <=> (-)-echitovenine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75840", "l": "H(+)(in) + K(+)(in) + Na(+)(out) + serotonin(out) => H(+)(out) + K(+)(out) + Na(+)(in) + serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67182", "l": "ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate => ATP + glycine + L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17592", "l": "2,2'-iminodipropanoate + H2O + NAD(+) <=> H(+) + L-alanine + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69140", "l": "RPA binds to the Flap (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10170", "l": "biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => 15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3244643", "l": "STING binds cyclic GMP-AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23115", "l": "6-methylsalicylate + H(+) <=> 3-methylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37352", "l": "cytidine 2'-phosphate + H2O => cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63639", "l": "a medium-chain fatty acyl-AMP + holo-[ACP] <=> a medium-chain fatty acyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69173", "l": "Joining of adjacent Okazaki fragments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669250", "l": "PAK1 phosphorylates FLNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8980691", "l": "RHOA GEFs activate RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003756", "l": "protein disulfide isomerase activity", "d": ["Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417896", "l": "P2Y6 receptor can bind to UDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74322", "l": "O-acetyl-(R)-carnitine(in) <=> O-acetyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12579", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose <=> (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39817", "l": "(R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36228", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52059", "l": "12-hexadecanoyloxy-octadecanoate + H2O <=> 12-hydroxyoctadecanoate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008984", "l": "protein-glutamate methylesterase activity", "d": ["Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59372", "l": "1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004586", "l": "ornithine decarboxylase activity", "d": ["Catalysis of the reaction: L-ornithine + H+ = CO2 + putrescine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58579", "l": "dihydroprecondylocarpine acetate + NADP(+) <=> H(+) + NADPH + precondylocarpine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944266", "l": "Association of procollagen type XI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19328", "l": "H(+) + NADH + O2 + quinolin-4-ol <=> H2O + NAD(+) + quinoline-3,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047194", "l": "indoleacetylglucose-inositol O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = 1L-1-O-(indol-3-yl)acetyl-myo-inositol + D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74017", "l": "CO2 + H2O + phenyl phosphate => 4-hydroxybenzoate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904678", "l": "alpha-aminoacyl-tRNA binding", "d": ["Binding to an alpha-aminoacyl-tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134954", "l": "DHX9 binds DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42786", "l": "2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine => adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44027", "l": "(3R)-3-hydroxydodecanoyl-CoA <=> (2E)-dodecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.184", "l": "\"UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65373", "l": "CMP-N-acetyl-beta-neuraminate + globoside GalGb4Cer => CMP + globoside MSGG + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72050", "l": "A + D-alanine + D-allothreonine + D-leucine + 2 L-leucine + L-proline <=> AH2 + fusahexin + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9688456", "l": "MLKL binds FLOT1, FLOT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029473", "l": "Branching and elongation of mother and daughter filaments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57587", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48906", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018746", "l": "RHOQ binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018492", "l": "carbon-monoxide dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70068", "l": "a C29-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a (22S)-22-hydroxy C29-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749351", "l": "CDT1-mediated formation of MCM2-7 double hexamer at the replication origin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63069", "l": "acetyl-CoA + 2 H(+) + 2 malonyl-CoA => 2 CO2 + 3 CoA + triacetate lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72822", "l": "L-ornithine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) <=> L-ornithine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977629", "l": "Displacement of C2a/Bb by CR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46779", "l": "a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36363", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH = (9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52536", "l": "adenosine + dGTP = AMP + dGDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080083", "l": "beta-gentiobiose beta-glucosidase activity", "d": ["Catalysis of the hydrolysis of glucosidic link in beta-gentiobiose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45494", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032781", "l": "WWTR1 (TAZ) binds TEAD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66798", "l": "11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14041", "l": "(R)-vicianin + H2O = mandelonitrile + vicianose", "d": []}, {"i": "EC:3.2.1.119", "l": "\"vicianin beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389350", "l": "Activation of Cdc42 by pVav1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16060", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55852", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2089971", "l": "Secretion of collagens (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909721", "l": "Translocation of ISGF3 complex to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16766", "l": "D-mannitol + NADP(+) => D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018586", "l": "mono-butyltin dioxygenase activity", "d": ["Catalysis of the reaction: butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyltin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190260", "l": "FGFR2b binds to FGF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73041", "l": "H(+)(in) + Ni(2+)(in) => H(+)(out) + Ni(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209199", "l": "CKA is phosphorylated by phosphorylated BSK kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32678", "l": "alpha,alpha-trehalose + H2O <=> alpha-D-glucose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0003823", "l": "antigen binding", "d": ["Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9774168", "l": "CDH19 gene expression is stimulated by ZC3H12A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28360", "l": "(2E)-tetradecenoyl-CoA + FADH2 => FAD + H(+) + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669240", "l": "FLNA binds PAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44600", "l": "a fatty acid + ATP + H(+) = a fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380294", "l": "Loss of C-Nap-1 from centrosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75806", "l": "butanoate(out) + Na(+)(out) <=> butanoate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66419", "l": "ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O <=> ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28039", "l": "[thioredoxin]-disulfide + dCDP + H2O => [thioredoxin]-dithiol + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.-.-", "l": "\"Acyltransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905057", "l": "voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels", "d": ["Any voltage-gated calcium channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60413", "l": "H2O + monoglucosyl-enterobactin => [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905575", "l": "ganglioside GM3 binding", "d": ["Binding to ganglioside GM3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66527", "l": "L-ascorbate(in) + monodehydro-L-ascorbate radical(out) <=> L-ascorbate(out) + monodehydro-L-ascorbate radical(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.58", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983144", "l": "Transport of Antigen peptide in to ER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009378", "l": "four-way junction helicase activity", "d": ["Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050059", "l": "lombricine kinase activity", "d": ["Catalysis of the reaction: ATP + lombricine = ADP + N-phospholombricine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62243", "l": "a thymidine(6-4)cytidine in DNA <=> a thymine-cytidine dinucleotide in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450551", "l": "AUF1 binds translation and heat shock proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31512", "l": "chenodeoxycholoyl-CoA + H2O => chenodeoxycholate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163595", "l": "2-acylglycerol + H2O -> glycerol + fatty acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44270", "l": "4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA => 3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19528", "l": "(2E,6E)-farnesyl diphosphate <=> (1S,8aR)-delta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9646468", "l": "mTORC1 binds RHEB:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0016657", "l": "oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a nitrogenous group."]}, {"i": "EC:1.6.6.-", "l": "\"With a nitrogenous group as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.134", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68566", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + scopoletin => 6-methoxycoumarin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018768", "l": "RHOU auto-activates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199425", "l": "PHLPP dephosphorylates S473 in AKT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033790", "l": "hydroxymethylfurfural reductase activity", "d": ["Catalysis of the reaction: 5-hydroxymethylfurfural + NAD(P)H + H+ = 2,5-bis-hydroxymethylfuran + NAD(P)+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009703", "l": "nitrate reductase (NADH) activity", "d": ["Catalysis of the reaction: nitrite + NAD+ + H2O = nitrate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10222", "l": "AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr) => ATP + L-tyrosine + tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983307", "l": "IL15 binds IL15RA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69477", "l": "acetyl-CoA + L-lysine => CoA + H(+) + N(6)-acetyl-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54260", "l": "2-oxoglutarate + L-asparaginyl-[protein] + O2 = (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36945", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70692", "l": "ornithine => putrescine + CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1834951", "l": "IFI16 binds cytosolic dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193650", "l": "p75NTR binds to NADE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001067", "l": "pullulan binding", "d": ["Binding to pullulan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937419", "l": "CBR3 reduces DOX to DOXOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62815", "l": "4 monapinone A + O2 <=> 2 dinapinone A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39275", "l": "(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH = (15Z)-tetracosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193653", "l": "NGF homodimer binds to p75NTR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983700", "l": "SYK binds the activated BCR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110219", "l": "Cleavage of thymine by TDG glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446322", "l": "PARVA associates with Paxillin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50085", "l": "ATP + H2O + taurolithocholate 3-sulfate(in) => ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186778", "l": "SHP2 binds to the active receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928645", "l": "EPHB:NMDAR binds TIAM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938773", "l": "RNF144A polyubiquitinates PRKDC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73346", "l": "beta-alanyl-5'-AMP + holo-[peptidyl-carrier protein] <=> AMP + beta-alanyl-[peptidyl-carrier protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25805", "l": "H2O + O2 + spermine => 3-aminopropanal + H2O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2186771", "l": "RNF111 binds SMAD7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43898", "l": "3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23705", "l": "GTP + 4 H2O => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46524", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58758", "l": "1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67863", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] <=> 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47655", "l": "D-ribitol 1-phosphate + H2O <=> phosphate + ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.088914107493508", "identifiers": [{"i": "GO:0016811", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140774", "l": "NAD-dependent protein depalmitoylase activity", "d": ["Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD+ + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:70563", "l": "H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72135", "l": "putrescine(out) = putrescine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782943", "l": "UV-DDB ubiquitinates XPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35902", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12594", "l": "a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76456", "l": "O-atom dealkylation of dextromethorphan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66860", "l": "dimethylallyl diphosphate + 4 isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49309", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O => a neolactoside nLc4Cer(d18:0) + L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35273", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43198", "l": "2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine => adenosine(4) in tRNA(His) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21856", "l": "cyclohexa-1,5-diene-1-carbonyl-CoA + H2O = 6-hydroxycyclohex-1-ene-1-carbonyl-CoA", "d": []}, {"i": "EC:4.2.1.100", "l": "\"cyclohexa-1,5-dienecarbonyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.358", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13033", "l": "aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-phosphate", "d": []}, {"i": "EC:5.3.1.26", "l": "\"galactose-6-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46128", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29836", "l": "D-galactonate(in) + H(+)(in) => D-galactonate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42248", "l": "butanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39730", "l": "a sphingomyelin(in) <=> a sphingomyelin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17215", "l": "UDP-N-acetyl-alpha-D-mannosamine => UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47390", "l": "an aliphatic alcohol + H(+) + tetradecanoate => a tetradecanoate ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41704", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28134", "l": "(2S)-hesperidin + H2O = (2S)-hesperetin + rutinose", "d": []}, {"i": "EC:3.2.1.168", "l": "\"hesperidin 6-O-alpha-L-rhamnosyl-beta-D-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44439", "l": "a 1,2-diacylglycerol + a 1-acylglycerol <=> a triacylglycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40214", "l": "(3S)-hydroxytetradecanedioyl-CoA + NAD(+) <=> 3-oxotetradecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70560", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O => L-threonyl-[protein] + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16369", "l": "(R)-lactate + NAD(+) = H(+) + NADH + pyruvate", "d": []}, {"i": "EC:1.1.1.28", "l": "\"D-lactate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50520", "l": "acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050608", "l": "vanillin dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + vanillin = 2 H+ + NADH + vanillate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052832", "l": "inositol monophosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5221061", "l": "TDG excises 5-carboxylcytosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632677", "l": "PTCH is internalized (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68909", "l": "ATP + H(+) + NADPH + picolinate => AMP + diphosphate + NADP(+) + picolinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11824", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate", "d": []}, {"i": "EC:2.1.2.11", "l": "\"3-methyl-2-oxobutanoate hydroxymethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59046", "l": "(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP => dammarenediol-II + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46018", "l": "H(+) + NADH + progesterone => (20R)-20-hydroxypregn-4-en-3-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61309", "l": "(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690873", "l": "ACO1 binds 4Fe-4S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023538", "l": "MECP2 binds PTPN1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5444523", "l": "Formation of MSH1:PMS2 Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140859", "l": "pterocarpan synthase activity", "d": ["Catalysis of the reaction: H2O + medicarpin = 4'-methoxyisoflavan-2',4,7-triol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54857", "l": "H(+) + NADPH + O2 + octan-3-one => ethyl hexanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46202", "l": "5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13494", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64012", "l": "acetyl-CoA + AH2 + 3 malonyl-CoA + 3 S-adenosyl-L-methionine = A + 3 CO2 + 4 CoA + fumigermin + H2O + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21265", "l": "A + glycolate => AH2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865276", "l": "PDGF-AB clevage by Furin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29004", "l": "H(+)(out) + L-homoserine(in) => H(+)(in) + L-homoserine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418846", "l": "Caspase cleavage of UNC5A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40571", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66690", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O => 4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.57", "l": "\"diamine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72713", "l": "4,21-dehydrogeissoschizine => cathenamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54047", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 7-epi-alpha-eudesmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645598", "l": "RRAGC,D hydrolyzes GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102237", "l": "ATP:farnesol kinase activity", "d": ["Catalysis of the reaction: 2-trans,-6-trans-farnesol + ATP = 2-trans,-6-trans-farnesyl monophosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211948", "l": "CYP3A4 can N-demethylate loperamide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848726", "l": "PTK6 phosphorylates BCAR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937177", "l": "AHR:TCDD binds ARNT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853429", "l": "PHLDA1 binds AURKA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018473", "l": "cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity", "d": ["Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + cis-2-methyl-5-isopropylhexa-2,5-dienoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650447", "l": "SERPING1 variant is not secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67827", "l": "a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O <=> a lipid X + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12179", "l": "phenylethanolamine + S-adenosyl-L-methionine <=> H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53276", "l": "17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] = 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047769", "l": "arogenate dehydratase activity", "d": ["Catalysis of the reaction: L-arogenate = L-phenylalanine + H2O + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209944", "l": "25(OH)D binds GC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41197", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+) => 1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26188", "l": "1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.250", "l": "\"D-inositol-3-phosphate glycosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74584", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-glutamyl-[protein] => N-acetyl-L-cysteine + N-terminal L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14589", "l": "luteolin + S-adenosyl-L-methionine = chrysoeriol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50921", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 => chromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627104", "l": "XIAP binds CASP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019841", "l": "retinol binding", "d": ["Binding to retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951966", "l": "EP300 acetylates RUNX3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11775", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68865", "l": "H2O + isomaltose => alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19911", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate => (S)-lactate + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59239", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + isoelisabethatriene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20725", "l": "a 4-saturated-(3S)-3-hydroxyacyl-CoA => a (3E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46796", "l": "an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174255", "l": "Degradation multiubiquitinated Cyclin A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74408", "l": "2 (S)-lactate(in) + thromboxane B2(out) => 2 (S)-lactate(out) + thromboxane B2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38170", "l": "hexadecan-1-ol + hexadecanoyl-CoA <=> CoA + hexadecanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4411373", "l": "NLK translocates to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24976", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008265", "l": "Mo-molybdopterin cofactor sulfurase activity", "d": ["Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166538", "l": "The bound receptor dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618331", "l": "HDAC6 deacetylates microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13788", "l": "(3S)-citramalyl-CoA <=> H2O + itaconyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63529", "l": "[thioredoxin]-dithiol + H2O2 => [thioredoxin]-disulfide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33284", "l": "2-hydroxycyclohexan-1-one + NADPH + O2 => 6-oxohexanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33470", "l": "5-dehydroepisterol + H(+) + NADPH + O2 <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193656", "l": "p75NTR interacts with RIP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853745", "l": "RET binds GFRA1,GFRA3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29774", "l": "arsenate(in) + ATP + H2O <=> ADP + arsenate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786101", "l": "IL4 binds IL4R:JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66795", "l": "N-methyl-D-dopa + O2 <=> (3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450550", "l": "PKCalpha phosphorylates HuR (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40233", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48057", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O => beta-D-glucosylceramide + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32523", "l": "nigerose + phosphate = beta-D-glucose 1-phosphate + D-glucose", "d": []}, {"i": "EC:2.4.1.279", "l": "\"nigerose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55958", "l": "(12R)-hydroxy-(9Z)-octadecenoate + A + H2O => (9Z)-octadecenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019970", "l": "interleukin-11 binding", "d": ["Binding to interleukin-11."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952081", "l": "RUNX proteins bind the p14-ARF promoter at the CDKN2A locus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332359", "l": "Active calmodulin binds CAMK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3878123", "l": "Initiation of SAHF formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444572", "l": "Zinc is an agonist of GPR39 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64879", "l": "H2O + UDP <=> H(+) + phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13979", "l": "NH4(+) + pyruvate => D-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.2.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58647", "l": "N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine <=> (9Z,12Z,15Z)-octadecatrienamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10252", "l": "H(+) + hydrogen sulfide + O-phospho-L-serine = L-cysteine + phosphate", "d": []}, {"i": "EC:2.5.1.65", "l": "\"O-phosphoserine sulfhydrylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6795290", "l": "TORC2 complex phosphorylates SGK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36058", "l": "a 2-amino-4-hydroxypteridine + H(+) + H2O <=> a 2,4-dihydroxypteridine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17875", "l": "ADP + an R-cob(III)alamin(in) + H(+) + phosphate => an R-cob(III)alamin(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004832", "l": "valine-tRNA ligase activity", "d": ["Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22599", "l": "cephalosporin C + H2O <=> acetate + deacetylcephalosporin C + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13113", "l": "2-acetamidofluorene + H2O + NADP(+) = H(+) + N-hydroxy-2-acetamidofluorene + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33155", "l": "a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate", "d": []}, {"i": "EC:3.1.3.106", "l": "\"2-lysophosphatidate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725342", "l": "NPM-ALK-dependent JUNB gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928656", "l": "gamma-secretase cleaves EPHB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990640", "l": "inositol-2,4,5-triphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 2,4,5-trisphosphate + H2O = 1D-myo-inositol 2,4-bisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672973", "l": "MAP2Ks phosphorylate MAPKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63462", "l": "(2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+) => (2E,6E,10E)-geranylgeraniol + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009282", "l": "CDK1 phosphorylates RUNX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18055", "l": "4-nitrophenol + diethylphosphate + 2 H(+) => H2O + paraoxon", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785607", "l": "FANCM binds FAAP24 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879909", "l": "Activation of STAT5a/b by JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0097506", "l": "deaminated base DNA N-glycosylase activity", "d": ["DNA N-glycosylase activity acting on deaminated bases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60813", "l": "2-oxoglutarate + gibberellin A12 aldehyde + O2 => CO2 + gibberellin A12 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26334", "l": "2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O => 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11816", "l": "alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate", "d": []}, {"i": "EC:5.3.1.9", "l": "\"glucose-6-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38793", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43457", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA => (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18886", "l": "GDP-beta-L-fucose + NADP(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75064", "l": "chloride(out) + 2 hydrogencarbonate(in) + Li(+)(in) => chloride(in) + 2 hydrogencarbonate(out) + Li(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47166", "l": "CO2 + NADH + zymosterone => 4alpha-carboxyzymosterol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033761", "l": "mugineic-acid 3-dioxygenase activity", "d": ["Catalysis of the reactions: mugineic acid + 2-oxoglutarate + O2 = 3-epihydroxymugineic acid + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350058", "l": "Formation of CSL NCOR corepressor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093329", "l": "EFNBs bind SDCBP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68727", "l": "26-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694592", "l": "3CLp dimer binds 3CLp inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75042", "l": "acetyl-CoA(in) <=> acetyl-CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61076", "l": "(-)-minovincinine + acetyl-CoA = (-)-echitovenine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909721", "l": "Translocation of ISGF3 complex to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164834", "l": "Enzyme-bound ATP is released (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31435", "l": "(2E,6E)-farnesyl diphosphate = (+)-alpha-santalene + diphosphate", "d": []}, {"i": "EC:4.2.3.82", "l": "\"alpha-santalene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757686", "l": "SERPINA6 binds PREDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390929", "l": "HTR1 and 5A receptors can bind serotonin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218820", "l": "Src kinases phosphorylate VAV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18906", "l": "H2O + phosphonoacetaldehyde => acetaldehyde + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879942", "l": "The receptor is activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66467", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O <=> scalarane-17alpha-19-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963589", "l": "ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22512", "l": "3 H(+) + precorrin-8X = hydrogenobyrinate", "d": []}, {"i": "EC:5.4.99.61", "l": "\"precorrin-8X methylmutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005484", "l": "SNAP receptor activity", "d": ["Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64843", "l": "2-phenylethanol + benzoyl-CoA <=> CoA + phenethyl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58516", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806974", "l": "MET dimers autophosphorylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70015", "l": "O2 + reduced [NADPH--hemoprotein reductase] + teasterone = 7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665413", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59192", "l": "ATP + eicosanoate + H(+) = diphosphate + icosanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46277", "l": "(S)-malate + H(+) => (S)-lactate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018800", "l": "5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity", "d": ["Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27993", "l": "1-deoxy-D-xylulose + ATP <=> 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981728", "l": "Factor H binds to membrane-associated C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61357", "l": "ATP + H2O + methotrexate(in) => ADP + H(+) + methotrexate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004021", "l": "L-alanine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77068", "l": "Activation of GT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31666", "l": "2-oxoglutarate + UDP-N-acetylbacillosamine <=> L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36909", "l": "(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA => (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654159", "l": "Activated FGFR2 binds PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62531", "l": "digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) <=> dihydrodigoxin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683679", "l": "Ubiquination of protein E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59876", "l": "(indol-3-yl)butanoate + ATP + L-cysteine = (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788346", "l": "Expression of IL13-upregulated plasma membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426530", "l": "Laminins:Nidogens binds HSPG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36330", "l": "ADP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50717", "l": "dimethyl sulfone + FMNH2 + O2 => FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72812", "l": "L-arginine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) => L-arginine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30257", "l": "2 a ubiquinone + 2 H2O => 2 a ubiquinol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49738", "l": "CO2 + deoxyviolacein + 2 H2O + NAD(+) => 2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017954", "l": "MECP2:SIN3A complex binds OPRM1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210769", "l": "HNF6- and FGF10-dependent synthesis of PDX1 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5604954", "l": "Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BIL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756603", "l": "SARS-CoV-1 S binds SFTPD 12mer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54264", "l": "2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36310", "l": "(E)-caffeoyl-CoA + H2O <=> 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19350", "l": "(R)-4-dehydropantoate + H2O + NAD(+) => (R)-3,3-dimethylmalate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23373", "l": "ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70692", "l": "ornithine => putrescine + CO2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9687625", "l": "ATP binds MLKL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67506", "l": "1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-nonadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65655", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine <=> a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67840", "l": "a lipid A disaccharide + ATP = a lipid IVA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40951", "l": "(2S)-2-acetamido-4-aminobutanoate + H2O = acetate + L-2,4-diaminobutanoate", "d": []}, {"i": "EC:3.5.1.125", "l": "\"N(2)-acetyl-L-2,4-diaminobutanoate deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.170", "l": "\"2-(omega-methylthio)alkylmalate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450494", "l": "HuR binds mRNAs in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55688", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O = 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37151", "l": "(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate = 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768832", "l": "SRF binds NPAS4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102191", "l": "4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol dehydrogenase/C4-decarboxylase activity", "d": ["Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) <=> 5alpha-cholesta-7,24-dien-3-one + NADH(2-) + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0035605", "l": "peptidyl-cysteine S-nitrosylase activity", "d": ["Catalysis of the transfer of a nitric oxide (NO) group to a sulphur atom within a cysteine residue of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038117", "l": "C-C motif chemokine 19 receptor activity", "d": ["Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42457", "l": "4alpha-methylzymosterol => zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35201", "l": "(S,S)-tartrate(in) => (S,S)-tartrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855232", "l": "RELN:VLDLR binds DAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611368", "l": "CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17145", "l": "2'-hydroxy-2,3-dihydrodaidzein + NADP(+) = 2'-hydroxydaidzein + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.51", "l": "\"2'-hydroxydaidzein reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052851", "l": "ferric-chelate reductase (NADPH) activity", "d": ["Catalysis of the reaction: 2 Fe3+-siderophore + NADP+ + H+ -> 2 Fe2+-siderophore + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004766", "l": "spermidine synthase activity", "d": ["Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19208", "l": "dCTP + 2 H2O <=> diphosphate + dUMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46690", "l": "3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2 => (25S)-3-oxocholest-4-en-26-oyl-CoA + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57842", "l": "1D-myo-inositol 1-phosphate + phosphate => 1D-myo-inositol 1,3-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73378", "l": "biotin(out) + 2 Na(+)(out) <=> biotin(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72103", "l": "Formation of pre-mRNPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686930", "l": "RIPK3 is cleaved by CASP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15560", "l": "ATP + H2O + Ni(2+)(out) <=> ADP + H(+) + Ni(2+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17368", "l": "ATP + H2O + Mn(2+)(out) <=> ADP + H(+) + Mn(2+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21914", "l": "acetyl-CoA + CO2 + H2O2 => CoA + H(+) + O2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981926", "l": "RAC1 and CDC42 activate PAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247849", "l": "WLS dissociates from retromer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051669", "l": "fructan beta-fructosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing 2,1- and 2,6-linked beta-D-fructofuranose residues in fructans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24300", "l": "2 cob(I)yrinate a,c diamide + FMN + 3 H(+) = 2 cob(II)yrinate a,c diamide + FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008974", "l": "phosphoribulokinase activity", "d": ["Catalysis of the reaction: D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.67", "l": "\"cis-muuroladiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17660", "l": "an acyl-CoA + dihydroxyacetone phosphate <=> a 1-acylglycerone 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53683", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 <=> 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59224", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + hydropyrene", "d": []}, {"i": "EC:4.2.3.201", "l": "\"hydropyrene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60633", "l": "all-trans-4-oxoretinol + NAD(+) => all-trans-4-oxoretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33081", "l": "adenine + dehypoxanthine futalosine => 6-amino-6-deoxyfutalosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70215", "l": "cortisol + H(+) + NADPH = 20beta-dihydrocortisol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29954", "l": "H(+)(in) + uridine(in) <=> H(+)(out) + uridine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647980", "l": "mature RAS proteins translocate to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64754", "l": "3-sulfanyl-1-pentanol + NH4(+) + pyruvate => 3-sulfanylpentan-1-ol-L-cysteine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070611", "l": "histone H3R2 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to the arginine residue at position 2 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52380", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847537", "l": "RAB43:GTP binds USP8NL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.81", "l": "\"streptogrisin B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58233", "l": "L-seryl-[protein] + NAD(+) => H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45099", "l": "(9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68615", "l": "Formation of ORC(1-6) complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15746", "l": "[(2->1)-beta-D-fructosyl](n) + sucrose => [(2->1)-beta-D-fructosyl](n+1) + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60429", "l": "(indol-3-yl)acetyl-L-aspartate + H2O => (indol-3-yl)acetate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73242", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether <=> H(+) + ladanein + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690494", "l": "RHOB translocates to the endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19234", "l": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] => H(+) + hexadecanoate + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27987", "l": "hydroxyacetone + NADP(+) => H(+) + methylglyoxal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70130", "l": "3-dehydro-6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41406", "l": "2-methyl-1-pyrroline + H(+) + NADPH => (R)-2-methylpyrrolidine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38242", "l": "(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA <=> 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41041", "l": "1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38481", "l": "H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine => N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.6", "l": "\"DNA-directed RNA polymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018826", "l": "methionine gamma-lyase activity", "d": ["Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72854", "l": "ADP(out) + AMP(in) <=> ADP(in) + AMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858482", "l": "DVL is recruited to the receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75467", "l": "ethanolamine(out) + n H(+)(in) = ethanolamine(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57451", "l": "ATP + D-tyrosine + tRNA(Tyr) <=> AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59326", "l": "D-xylono-1,5-lactone + H2O2 => D-xylose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42684", "l": "gamma-L-glutamyl-hercynylcysteine S-oxide + H2O = L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": []}, {"i": "EC:3.5.1.118", "l": "\"gamma-glutamyl hercynylcysteine S-oxide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909729", "l": "Activation of JAK kinases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870465", "l": "RGGT binds the RAB-binding subunit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691621", "l": "C5 binds C5 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40343", "l": "3-oxohexadecanedioyl-CoA + CoA = acetyl-CoA + tetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38356", "l": "(R)-3-phenyllactoyl-CoA => (E)-cinnamoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22367", "l": "L-quinate + NAD(+) <=> 3-dehydroquinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43999", "l": "2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2 <=> a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198314", "l": "DAG stimulates protein kinase C-delta (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25488", "l": "(2E)-geranyl diphosphate = (1S,5S)-alpha-pinene + diphosphate", "d": []}, {"i": "EC:4.2.3.119", "l": "\"(-)-alpha-pinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983152", "l": "Transfer of ubiquitin from E1 to E2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362386", "l": "Glycosylation of Hh (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5618107", "l": "ATP binding to HSP90 triggers conformation change (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49370", "l": "19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate => 19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209536", "l": "IkB is ubiquitinated and degraded (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50583", "l": "acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58502", "l": "glyoxylate + H2O + NAD(+) + trimethylamine => glycine betaine + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2429719", "l": "MCPH1 sequesters condensin II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029460", "l": "PAK1 phosphorylates LIMK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805811", "l": "Release of SEPT4 from mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38868", "l": "uridine(516) in 16S rRNA => pseudouridine(516) in 16S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40317", "l": "(2E)-glutaconyl-CoA + H2O2 => glutaryl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52315", "l": "NAD(+) + thromboxane B2 <=> 11-dehydro-thromboxane B2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21476", "l": "[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.34", "l": "\"1,3-beta-glucan synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36650", "l": "2-hydroxyhexadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102130", "l": "malonyl-CoA methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a malonyl-[acp] = S-adenosyl-L-homocysteine + a malonyl-[acp] methyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53645", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-corvol ether B + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022393", "l": "ANPEP hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69152", "l": "Removal of remaining Flap (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-992696", "l": "p53, SIN3A and MYB form a complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58445", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57018", "l": "3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35145", "l": "2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA => benzoyl-CoA + 2 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951500", "l": "Dissociation of CANX from nonameric complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37812", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29963", "l": "H(+)(in) + inosine(in) = H(+)(out) + inosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18698", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) => (4-hydroxyphenyl)acetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950741", "l": "IL12B:IL23A translocates from ER lumen to extracellular space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22402", "l": "17beta-hydroxyandrostanone + H(+) + NADH => androstan-3alpha,17beta-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40258", "l": "(2E)-hexadecenedioyl-CoA + H2O <=> (3R)-hydroxyhexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423694", "l": "AFBDHD hydrolyses non-enzymatically to AFBDHO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8980691", "l": "RHOA GEFs activate RHOA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730752", "l": "NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797803", "l": "PTPRD binds SLITRK1-6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76003", "l": "glutarate(in) + xanthurenate(out) = glutarate(out) + xanthurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73177", "l": "ADP(out) + FMN(in) => ADP(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65738", "l": "CO2 + H(+) + octanal + succinate + sulfate => 2-oxoglutarate + O2 + octyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731009", "l": "SARS-CoV-1 nsp3 binds to IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63156", "l": "H2O + N-docosanoyl-taurine = docosanoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42423", "l": "2-oxoglutarate + L-lysine + O2 <=> (4R)-4-hydroxy-L-lysine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686318", "l": "GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2529020", "l": "CK2 phosphorylates condensin I subunits (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73383", "l": "thiamine diphosphate(in) + thiamine phosphate(out) = thiamine diphosphate(out) + thiamine phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25305", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O <=> 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68017", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H2O => (2E,6E,10E)-geranylgeraniol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45746", "l": "7,8-dihydropteroate + H(+) + NADH => (6S)-5,6,7,8-tetrahydropteroate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0005009", "l": "insulin receptor activity", "d": ["Combining with insulin receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}, {"i": "REACT:R-HSA-74715", "l": "Autophosphorylation of insulin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140585", "l": "promoter-enhancer loop anchoring activity", "d": ["Bridging together two cis-regulatory elements, colloquially referred to as promoters and/or enhancers, holding two loop anchors together to maintain a chromatin loop."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42967", "l": "uridine(54/55) in tRNA <=> pseudouridine(54/55) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.1.2", "l": "\"hydrogen dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983147", "l": "Release of E3 from polyubiquitinated substrate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13825", "l": "GDP-alpha-D-rhamnose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938853", "l": "CDK6 binds RUNX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55039", "l": "an N,N-dimethylornithine lipid + S-adenosyl-L-methionine <=> an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24439", "l": "H2 + methanophenazine <=> dihydromethanophenazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58532", "l": "15alpha-stemmadenine intermediate I + H2O = akuammicine + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24570", "l": "an alcohol + D-galactose 6-phosphate => a 6-phospho-beta-D-galactoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73836", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate => 2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709842", "l": "MAVS binds TOMM70 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047341", "l": "fucose-1-phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: beta-L-fucose 1-phosphate + GTP + H+ = diphosphate + GDP-beta-L-fucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12568", "l": "4-nitrophenol + H(+) + NADH + O2 = 4-nitrocatechol + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.29", "l": "\"4-nitrophenol 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24776", "l": "H2O + pheophorbide a = C-13(2)-carboxypyropheophorbide a + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140344", "l": "triglyceride transfer activity", "d": ["Directly binding to a triglyceride and delivering it either to an acceptor molecule or to a specific location."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62033", "l": "a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O => a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176116", "l": "Recruitment and activation of Chk1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106177", "l": "cyclic-GMP-AMP hydrolase activity", "d": ["Catalysis of the reaction: cyclic GMP-AMP + 2 H2O = AMP + GMP."]}, {"i": "RHEA:58808", "l": "2',3'-cGAMP + 2 H2O = AMP + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867041", "l": "EGFR phosphorylates EPS15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49676", "l": "H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 = H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65281", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate => 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Ser-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50054", "l": "ADP + H(+) + phosphate + taurocholate(out) => ATP + H2O + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43191", "l": "S-adenosyl-L-methionine + uridine(2634) in 25S rRNA <=> H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69582", "l": "2'-deoxyguanosine + IMP => dGMP + inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250220", "l": "Homodimerization of ERBB4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050571", "l": "1,5-anhydro-D-fructose reductase activity", "d": ["Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP+ = 1,5-anhydro-D-fructose + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196964", "l": "RFK:Mg2+ phosphorylates RIB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6805640", "l": "AKT phosphorylates KAT6A (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29372", "l": "dAMP + H2O => 2'-deoxyadenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665748", "l": "FMNL2 binds RHOC:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2172666", "l": "RB1 binds condensin II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27411", "l": "3 a menaquinol + protoporphyrin IX => 3 a menaquinone + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64666", "l": "a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734730", "l": "ORC1 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730892", "l": "Recruitment of VAV to p-SLP-76 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23924", "l": "pppGp(2'-5')A = 2',3'-cGAMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.48", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036173", "l": "thiosulfate binding", "d": ["Binding to a thiosulfate, a sulfur oxide that has formula O3S2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66933", "l": "(E)-4-coumaroyl-CoA + 5-hydroxyanthranilate => avenanthramide A + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48318", "l": "a ganglioside GD1alpha + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17150", "l": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] => an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483174", "l": "PE is methylated to PC by PEMT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437230", "l": "L1-FGFR cis-heterodimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39916", "l": "1-O-alkyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11016", "l": "allantoate + H2O = (S)-ureidoglycolate + urea", "d": []}, {"i": "EC:3.5.3.4", "l": "\"allantoicase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17788", "l": "H(+) + L-glutamate <=> 4-aminobutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61337", "l": "ATP + H2O + protoporphyrin IX(in) => ADP + H(+) + phosphate + protoporphyrin IX(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692150", "l": "SOX9 binds the DHH gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41858", "l": "(3R)-hydroxydecanoyl-[ACP] + NADP(+) => 3-oxodecanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19055", "l": "H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63923", "l": "octadecanoyl-CoA + sphinga-4E,14Z-dienine <=> CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879674", "l": "CD97 binds CD55 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41705", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O => 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49112", "l": "phenazine-1-carboxylate + S-adenosyl-L-methionine = 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.327", "l": "\"phenazine-1-carboxylate N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23687", "l": "(S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11641", "l": "a (2R,3R)-flavan-3-ol + 2 NAD(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080025", "l": "phosphatidylinositol-3,5-bisphosphate binding", "d": ["Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189439", "l": "ALAD condenses 2 dALAs to form PBG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55005", "l": "1-hydroxylimonen-2-one + NADPH + O2 => 3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001588", "l": "dopamine neurotransmitter receptor activity, coupled via Gs", "d": ["Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33710", "l": "ATP + L-threonine <=> ADP + H(+) + O-phospho-L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33962", "l": "2-oxoglutarate + neomycin C <=> 6'''-deamino-6'''-oxoneomycin C + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46205", "l": "androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] => androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.148", "l": "\"acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63847", "l": "[thioredoxin]-dithiol + cumene hydroperoxide <=> 2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68200", "l": "1,2-dihexanoylglycerol + hexadecanoyl-CoA = 1,2-dihexanoyl-3-hexadecanoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19443", "l": "3-hydroxy-cis,cis-muconate + 2 H(+) => benzene-1,2,4-triol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64782", "l": "2-aminoprop-2-enoate + benzylthiol => S-benzyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180602", "l": "Association of Vif with APOBEC3G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932084", "l": "RUNX1 and ESR1 bind the AXIN1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35340", "l": "3-hydroxyicosanoyl-CoA + NADP(+) => 3-oxoeicosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27331", "l": "5-hydroxyisourate + H2O + NAD(+) => H(+) + NADH + O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23134", "l": "7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite => 3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59912", "l": "(E)-4-hydroxynon-2-enal + H2O + NADP(+) = (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75730", "l": "(10E,12Z)-octadecadienoate + H2O <=> (10S)-hydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203716", "l": "eNOS:Caveolin-1 complex binds to Nostrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062057", "l": "L-aspartate:fumarate antiporter activity", "d": ["Enables the transport of L-aspartate and fumarate across a membrane according to the reaction L-aspartate (out) + fumarate (in) = L-aspartate (in) + fumarate (out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13622", "l": "4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose => 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759157", "l": "NFE2L2-dependent SQSTM1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755359", "l": "SARS-CoV-2 8:class I MHC binds BECN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38876", "l": "uridine(2604) in 23S rRNA => pseudouridine(2604) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984671", "l": "Chromokinesins form dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65861", "l": "A + Delta(1)-dihydrotestosterone + H2O => 17beta-hydroxyandrostan-1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018572", "l": "EGFR phosphorylates NOTCH3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111264", "l": "Addition of nucleotides between position +11 and +30 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64712", "l": "1-propanol + NADP(+) = H(+) + NADPH + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67047", "l": "A + asnovolin H <=> AH2 + chermesin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62585", "l": "ATP + H2O + L-tyrosine(out) => ADP + H(+) + L-tyrosine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23387", "l": "D-cellobiose <=> beta-D-glucosyl-(1->4)-D-mannopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74201", "l": "(2Z)-2-[(3,4-dioxocyclohexa-1,5-dien-1-yl)methylidene]-4-(4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-olate + H2O => aspulvinone E + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17333", "l": "O-acetyl-L-serine + zeatin = acetate + H(+) + L-lupinate", "d": []}, {"i": "EC:2.5.1.50", "l": "\"zeatin 9-aminocarboxyethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58764", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696997", "l": "USP24 deubiquitinates DDB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14313", "l": "2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.26", "l": "\"iodophenol O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434836", "l": "Syk/Lck phosphorylate LAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034280", "l": "ent-sandaracopimaradiene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45787", "l": "2 H2O + phenylpropanonitrile <=> 3-phenylpropanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65702", "l": "cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28614", "l": "(1Z,2S)-2-methylbutanal oxime = (2S)-2-methylbutanenitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805479", "l": "TP53RK phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76045", "l": "2 H(+) + H2O + muramine + oxidized [NADPH--hemoprotein reductase] => (S)-cis-N-methyltetrahydropalmatine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46475", "l": "4alpha-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.7.-.-", "l": "\"Forming nitrogen-nitrogen bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30167", "l": "D-erythrose 4-phosphate + dihydroxyacetone phosphate = D-sedoheptulose 1,7-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10073", "l": "N,N-dimethylglycine + S-adenosyl-L-methionine => glycine betaine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665989", "l": "DIAPH1 binds RHOA:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19838", "l": "D-sorbitol 6-phosphate + NAD(+) => beta-D-fructose 6-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65912", "l": "3-hydroxy-L-kynurenine + pyruvate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68559", "l": "NAD(+) + UDP-N-acetyl-alpha-D-quinovosamine <=> H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42577", "l": "2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O => 2-methylpropanoate + 2-oxopent-4-enoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21492", "l": "2,3-dihydroxybenzoate + H(+) = catechol + CO2", "d": []}, {"i": "EC:4.1.1.46", "l": "\"o-pyrocatechuate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35126", "l": "H(+)(out) + L-alanyl-D-glutamate(out) <=> H(+)(in) + L-alanyl-D-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727303", "l": "mRNA9 is translated to protein 9b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690152", "l": "USP5 cleaves polyubiquitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45953", "l": "L-asparaginyl-[protein] + UDP-alpha-D-glucose => H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14634", "l": "ATP + H2O + Na(+)(in) => ADP + H(+) + Na(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34422", "l": "(+)-lariciresinol + NADP(+) <=> (+)-pinoresinol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63683", "l": "(7R,8S)-7,8-diammoniononanoate + CO2 <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68610", "l": "Formation of ORC(2-5) complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8957241", "l": "TP73 tetramer translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110215", "l": "Cleavage of uracil by UNG glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167181", "l": "Addition of nucleotides leads to HIV-1 transcript elongation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021596", "l": "Membrane estrogen receptors bind SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47124", "l": "glycine + hexacosanoate = H2O + N-hexacosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662649", "l": "MT4 binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010176", "l": "homogentisate phytyltransferase activity", "d": ["Catalysis of the reaction: homogentisate + phytyl diphosphate + H+ = 2-methyl-6-phytyl-1,4-benzoquinone + CO2 + diphosphate. 2-methyl-6-phytyl-1,4-benzoquinone is also known as 2-methyl-6-phytylplastoquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68817", "l": "(2Z,6E)-farnesyl diphosphate => (E)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51991", "l": "(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O <=> 18S-resolvin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0035596", "l": "methylthiotransferase activity", "d": ["Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22811", "l": "6-hydroxynicotinate + H2O + O2 <=> 2,6-dihydroxynicotinate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201608", "l": "Caspase-mediated cleavage of alpha adducin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195251", "l": "Assembly of the destruction complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50533", "l": "acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30826", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21869", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O => 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25841", "l": "5-deoxy-D-glucuronate => 5-dehydro-2-deoxy-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46553", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33254", "l": "2 sucrose <=> 6-kestotriose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.94", "l": "\"ethylmalonyl-CoA decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950387", "l": "CANX binds EBI3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382061", "l": "Extracellular processing of novel PDGFs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1861789", "l": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23340", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate = D-arabinose + pyruvate", "d": []}, {"i": "EC:4.1.2.23", "l": "\"3-deoxy-D-manno-octulosonate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46260", "l": "an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50456", "l": "prostaglandin H3 = prostaglandin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53358", "l": "H(+) + NADPH + uridine(20b) in tRNA => 5,6-dihydrouridine(20b) in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14121", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350578", "l": "NQO1 interaction with ODC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043426", "l": "MRF binding", "d": ["Binding to Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.863640214551324", "identifiers": [{"i": "GO:0005525", "l": "GTP binding", "d": ["Binding to GTP, guanosine triphosphate."]}, {"i": "REACT:R-HSA-167429", "l": "The receptor:G-protein complex  binds GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13185", "l": "H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)", "d": []}, {"i": "EC:2.5.1.61", "l": "\"hydroxymethylbilane synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27776", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31690", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73236", "l": "2,6-dichlorobenzoquinone + H2O => 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8856951", "l": "PP2A demethylation by PPME1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023159", "l": "Carboxypeptidase E hydrolyzes Insulin(57-89) to yield C-peptide (Insulin(57-87)) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10335", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.23", "l": "\"[heparan sulfate]-glucosamine 3-sulfotransferase 1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25312", "l": "glycolate + O2 => glyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032115", "l": "sorbose reductase activity", "d": ["Catalysis of the reaction: D-glucitol + NADP+ = L-sorbose + H+ + NADPH. The reaction may occur, to a minor extent, in the reverse direction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754129", "l": "CDK6 inhibitors bind CDK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198621", "l": "AKT phosphorylates caspase-9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58363", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 <=> (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173631", "l": "Activation of C1s (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71136", "l": "H(+)(in) + L-histidine(out) + Na(+)(out) => H(+)(out) + L-histidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64776", "l": "3-sulfanylpentan-1-ol-L-cysteine = 2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17336", "l": "O-acetyl-L-serine + zeatin <=> acetate + H(+) + L-lupinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659922", "l": "Defective SI does not hydrolyze Mal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41994", "l": "5alpha-androstan-3,17-dione + H(+) + NADH => 17beta-hydroxy-5alpha-androstan-3-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40143", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75850", "l": "Addition of the third nucleotide on the nascent transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37025", "l": "(6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34706", "l": "(2E,6E)-farnesyl diphosphate <=> (E)-2-epi-beta-caryophyllene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68188", "l": "dodecanoyl-CoA + phytol = CoA + dodecanoate phytyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51379", "l": "dopamine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoyl-dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23433", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39506", "l": "(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH <=> (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0047267", "l": "undecaprenyl-phosphate mannosyltransferase activity", "d": ["Catalysis of the reaction: GDP-mannose + undecaprenyl phosphate = GDP + D-mannosyl-1-phosphoundecaprenol."]}, {"i": "EC:2.4.1.54", "l": "\"undecaprenyl-phosphate mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29637", "l": "alpha-D-glucose + D-maltotetraose => D-maltopentaose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63283", "l": "a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 <=> a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47414", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25361", "l": "biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin] => (3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004085", "l": "butyryl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34853", "l": "3-oxoadipyl-CoA + H(+) + NADH => (3S)-3-hydroxyadipyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57456", "l": "(E)-sinapate + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51423", "l": "a (2S,3S)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23874", "l": "(R)-lactaldehyde + H(+) + NADH => (R)-propane-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805792", "l": "p-S291-PHF20 translocates to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50192", "l": "L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.2.26", "l": "\"protein xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373724", "l": "Nephrin binds NCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24264", "l": "D-xylulose 5-phosphate + formaldehyde = D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": []}, {"i": "EC:2.2.1.3", "l": "\"formaldehyde transketolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37877", "l": "methyl aklanonate + S-adenosyl-L-homocysteine => aklanonate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0035259", "l": "nuclear glucocorticoid receptor binding", "d": ["Binding to a nuclear glucocorticoid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668545", "l": "NIK autophosphorylates on T559 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692738", "l": "HRH2 binds HRH2 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34058", "l": "festuclavine + NAD(+) <=> 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48115", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10444", "l": "(S)-reticuline + S-adenosyl-L-methionine = (S)-laudanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20913", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + taxa-4,11-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22432", "l": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.35", "l": "\"3-hydroxyacyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210439", "l": "glutamate uptake by astrocytes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62099", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(9Z-octadecenoyl)-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.12", "l": "\"cGMP-dependent protein kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40030", "l": "9alpha-copalyl diphosphate + H2O <=> (13S)-vitexifolin A + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755303", "l": "26S proteasome degrades HIFalpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-435244", "l": "PECAM1 is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17783", "l": "formate + L-methionine => H2O + N-formyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49071", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013004", "l": "RHOA binds effectors at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684096", "l": "CDK2 phosphorylates RBBP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24041", "l": "NADPH + 2 oxidized [cytochrome P450] => H(+) + NADP(+) + 2 reduced [cytochrome P450]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17844", "l": "trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018519", "l": "cis-dihydroethylcatechol dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydro-3-ethylcatechol + NAD+ = 3-ethylcatechol + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44409", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O => a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44317", "l": "1-dodecanoylglycerol + H2O => dodecanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944214", "l": "Association of procollagen type I (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806610", "l": "Keratin filament formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38131", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58966", "l": "H(+) + H2O2 + hexanoate => H2O + hexanal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.43", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102818", "l": "lycopene cleavage oxygenase activity", "d": ["Catalysis of the reaction: lycopene + 2 O2 <=> 2 sulcatone + bixin aldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852019", "l": "MET bound PI3K generates PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12027", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + choline <=> D-glucose + O-sinapoylcholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25249", "l": "H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430158", "l": "p-SLP-76 binds VAV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167477", "l": "Abortive HIV-1 initiation after formation of the first phosphodiester bond (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018601", "l": "4-nitrophenol 2-monooxygenase activity", "d": ["Catalysis of the reaction: 4-nitrophenol + H+ + NADH + O2 = 4-nitrocatechol + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37147", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443784", "l": "Cis-heterodimerization of L1 and Contactin-1/F3/F11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45848", "l": "(3R)-3-hydroxydodecanoyl-CoA + NADP(+) = 3-oxododecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43721", "l": "juvenile hormone III carboxylate + S-adenosyl-L-methionine => juvenile hormone III + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667965", "l": "ANKLE2 binds PP2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16157", "l": "2 Fe(III)-[leghemoglobin] + NADPH = 2 Fe(II)-[leghemoglobin] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617179", "l": "PRKACA phosphorylates TNNI3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353271", "l": "Cleavage of uracil by Uracil-glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69423", "l": "H2O2 + iodide <=> H2O + hypoiodite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18404", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43788", "l": "acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate", "d": []}, {"i": "EC:2.3.1.193", "l": "\"tRNA(Met) cytidine acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23992", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": []}, {"i": "EC:2.3.1.63", "l": "\"1-alkylglycerophosphocholine O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37034", "l": "D-ribonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41186", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034818", "l": "ADD 9alpha-hydroxylase activity", "d": ["Catalysis of the reaction: androsta-1,4-diene-3,17-dione + reduced ferredoxin + O2 = 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + oxidized ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050597", "l": "taxane 10-beta-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140798", "l": "histone H3R26 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H3 L-arginyl (position 26)= histone H3 L-citrullyl (position 26) + NH4+, resulting in histone H3 citrullination at position 26."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604763", "l": "Autocatalytic activation of MMP7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265177", "l": "Exocyst complex formation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.-", "l": "\"Protein-serine/threonine kinases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174445", "l": "RPA binds to the Flap on the C-strand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42516", "l": "H2O + L-gulono-1,4-lactone = H(+) + L-gulonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55959", "l": "(9Z)-octadecenoate + AH2 + O2 <=> (12R)-hydroxy-(9Z)-octadecenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25786", "l": "(S)-lactaldehyde + pyruvate => 2-dehydro-3-deoxy-L-rhamnonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70619", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38273", "l": "3-methylfumaryl-CoA + H2O => (3S)-citramalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22072", "l": "ATP + L-ribulose = ADP + H(+) + L-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17881", "l": "H2O + N-sulfo-D-glucosamine = D-glucosamine + sulfate", "d": []}, {"i": "EC:3.10.1.1", "l": "\"N-sulfoglucosamine sulfohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74074", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32086", "l": "CTP + pseudaminate <=> CMP-pseudaminate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72224", "l": "4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out) => 4-hydroxy-L-proline + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75172", "l": "Formation of RAD50:MRE11 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71971", "l": "3-hydroxyglutarate(out) + 3 Na(+)(out) = 3-hydroxyglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388828", "l": "PD-1 binds B7DC and B7H1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.14.-", "l": "\"Protein-arginine kinases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211950", "l": "CYP24A1 24-hydroxylates CTL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194678", "l": "CYP51A1 demethylates LNSOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63714", "l": "a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050450", "l": "citrate (Re)-synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the re-face of oxaloacetate; acetyl-CoA provides the two carbon atoms of the pro-R carboxymethyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674140", "l": "PAQR3 binds inactive RAFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113402", "l": "Formation of DSIF:NELF:early elongation complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42811", "l": "2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-L-Glu)(n) <=> 3 reduced coenzyme F420-(gamma-L-Glu)(n) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40741", "l": "(20S)-ginsenoside C-Y + 2 D-glucose => (20S)-ginsenoside Rb2 + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296127", "l": "Activation of voltage gated Potassium channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097260", "l": "eoxin A4 synthase activity", "d": ["Catalysis of the reaction: leukotriene A4 = eoxin A4."]}, {"i": "REACT:R-HSA-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28006", "l": "H2O + N(alpha)-methyl-L-tryptophan + O2 = formaldehyde + H2O2 + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050239", "l": "pyrithiamine deaminase activity", "d": ["Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61065", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine => beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20256", "l": "(2R,3S)-2,3-dimethylmalate <=> dimethylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31704", "l": "2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42940", "l": "cytidine(34) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60137", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 => a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030782", "l": "(S)-tetrahydroprotoberberine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35288", "l": "ATP + chloramphenicol(in) + H2O => ADP + chloramphenicol(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047139", "l": "glutathione-homocystine transhydrogenase activity", "d": ["Catalysis of the reaction: homocystine + 2 reduced glutathione = oxidized glutathione + 2 homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69807", "l": "benzoyl-AMP + CoA = AMP + benzoyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12649", "l": "L-rhamnofuranose + NAD(+) = H(+) + L-rhamnono-1,4-lactone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667619", "l": "AVPR1A,B,2 bind atosiban (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005131", "l": "growth hormone receptor binding", "d": ["Binding to a growth hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27901", "l": "3'-AMP + H2O <=> adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9728150", "l": "SLC5A2 binds gliflozins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37688", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45479", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339713", "l": "Misspliced GSK3beta mutants stabilize beta-catenin levels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-178208", "l": "SMAD7 binds to SMURF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395517", "l": "NADPH transfers electrons to FDXR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23222", "l": "4-chlorobenzoyl-CoA + AMP + diphosphate => 4-chlorobenzoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73426", "l": "L-asparagine(out) <=> L-asparagine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654569", "l": "Activated FGFR1 binds FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008426", "l": "protein kinase C inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60960", "l": "18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose = (9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38825", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749215", "l": "MCM8 binds CDC6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0070137", "l": "ubiquitin-like protein-specific endopeptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390930", "l": "5-HT2 receptor can bind serotonin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21452", "l": "a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": []}, {"i": "EC:1.14.17.3", "l": "\"peptidylglycine monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007220", "l": "E2F6:TFDP1/2 binds the E2F1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58616", "l": "N-octanoyl-(2S)-hydroxyglycine = glyoxylate + octanamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.272", "l": "\"D-2-hydroxyacid dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357472", "l": "PAK1-3 autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168888", "l": "Alpha1-Microglobulin binds heme (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66301", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose => an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61186", "l": "H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP => quercitrin + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.131", "l": "\"mannuronate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800490", "l": "ATM phosphorylates PIDD1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428917", "l": "G13 activation by TP receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3076905", "l": "Extracellular BTD hydrolyses BCTN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2203480", "l": "COLEC11 binds ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30110", "l": "D-serine + NADP(+) <=> 2-aminomalonate semialdehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627056", "l": "Procaspase 9 forms dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11765", "l": "H2O + methylguanidine => methylamine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34452", "l": "dTDP-6-deoxy-beta-L-talose => dTDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0005536", "l": "glucose binding", "d": ["Binding to D- or L-enantiomers of glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163320", "l": "Association of mTERF with the termination sequence (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30231", "l": "H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine = (2E,6E)-farnesal + H2O2 + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769394", "l": "AKT phosphorylates CBY1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62781", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57850", "l": "CO2 + fraxetin + succinate => 2-oxoglutarate + O2 + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39946", "l": "a 1-acylglycerol + an acyl-CoA <=> a 1,2-diacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64733", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68251", "l": "L-tyrosine(in) + Na(+)(in) <=> L-tyrosine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989748", "l": "Expression of GRHL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69829", "l": "(22R,23R)-22,23-dihydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39726", "l": "a 1,2-diacyl-sn-glycerol(in) <=> a 1,2-diacyl-sn-glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19513", "l": "carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate", "d": []}, {"i": "EC:2.1.3.3", "l": "\"ornithine carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.2.6", "l": "\"leghemoglobin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41337", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50239", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] <=> 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32785", "l": "ADP + glycine betaine(in) + H(+) + phosphate => ATP + glycine betaine(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72332", "l": "3-hydroxy-4-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483186", "l": "PC is converted to PS by PTDSS1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37576", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855188", "l": "IP6 transports from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74826", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74112", "l": "H(+) + hypotaurine + NADH + O2 => H2O + NAD(+) + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024386", "l": "Oxysterol-induced binding of NR1H2,3:RXR to the ABCG1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141423", "l": "Binding of the MCC complex to the APC/C complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39718", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 <=> (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66495", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395764", "l": "atREs binds to nascent CM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55161", "l": "coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54609", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31750", "l": "3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) <=> 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66819", "l": "2 Na(+)(in) + tetrahydroxoborate(in) <=> 2 Na(+)(out) + tetrahydroxoborate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51427", "l": "a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389532", "l": "PP2A binds CTLA4 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19376", "l": "H2O + L-saccharopine + NADP(+) <=> 2-oxoglutarate + H(+) + L-lysine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23052", "l": "ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]", "d": []}, {"i": "EC:2.7.11.2", "l": "\"[pyruvate dehydrogenase (acetyl-transferring)] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55008", "l": "(1R,4S)-1-hydroxylimonen-2-one + NADPH + O2 = (3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56172", "l": "FMN + O2 = 8-demethyl-8-formylriboflavin 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451377", "l": "Interaction of IQGAP1 with nephrin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66522", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31377", "l": "1H-pyrrole + CO2 => H(+) + pyrrole-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20303", "l": "AMP + diphosphate + L-arginyl-tRNA(Arg) => ATP + L-arginine + tRNA(Arg)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73983", "l": "(2E,6E)-farnesyl diphosphate = (-)-beta-barbatene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14220", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] <=> [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23502", "l": "3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58018", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18805", "l": "[DsbA protein]-disulfide + [protein]-dithiol = [DsbA protein]-dithiol + [protein]-disulfide", "d": []}, {"i": "EC:1.8.4.15", "l": "\"protein dithiol oxidoreductase (disulfide-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13706", "l": "alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine => alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052611", "l": "beta-carotene 3-hydroxylase activity", "d": ["Catalysis of the reaction: beta-carotene + a reduced electron acceptor + oxygen = beta-cryptoxanthin + an oxidized electron acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607734", "l": "PKC-delta translocates to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015374", "l": "neutral, basic amino acid:sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/basic amino acid(out) + Na+(out) + Cl-(out) = neutral/basic amino acid(in) + Na+(in) + Cl-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218820", "l": "Src kinases phosphorylate VAV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32204", "l": "(R)-synephrine => (4-hydroxyphenyl)acetaldehyde + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166175", "l": "TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.-", "l": "\"Enzymes altering nucleic acid conformation\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25256", "l": "ATP + N-acetyl-D-mannosamine <=> ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008693", "l": "(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O."]}, {"i": "RHEA:41860", "l": "(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33578", "l": "an inositol-1-phosphophytoceramide + beta-D-mannose <=> a mannosylinositol-1-phosphophytoceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32947", "l": "a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045127", "l": "N-acetylglucosamine kinase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14754", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021609", "l": "ESR-associated SRC autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45509", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin beta-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45416", "l": "11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O = 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18122", "l": "an S-substituted L-cysteine + H2O => a thiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72875", "l": "anthocyanin A7 + malonyl-CoA = anthocyanin A9 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73008", "l": "D-arabinose 5-phosphate => D-glyceraldehyde 3-phosphate + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11970", "l": "7,8-dihydro-7,8-dihydroxykynurenate + A => AH2 + kynurenate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865454", "l": "CBFB binds RUNX3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75862", "l": "Fall Back to Closed Pre-initiation Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34529", "l": "(S)-3-amino-3-phenylpropanoate => L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936563", "l": "ISGylation of DDX58 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42143", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-(4R)-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19329", "l": "nuatigenin + UDP-alpha-D-glucose = H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP", "d": []}, {"i": "EC:2.4.1.192", "l": "\"nuatigenin 3beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222526", "l": "AhpC reduces peroxidated lipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42898", "l": "H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine => L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62334", "l": "adenosine 3'-diphosphate,5'-diphosphate + AMP => ADP + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27792", "l": "3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-octaprenylphenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42129", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49426", "l": "ADP + H(+) + validone 7-phosphate => ATP + validone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606839", "l": "Steryl sulfatase hydrolyses sulfate from steroid sulfates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11614", "l": "2-oxoglutarate + H(+) + NADPH + NH4(+) => H2O + L-glutamate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814409", "l": "CK2 phosphorylates PDCL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102762", "l": "eriodictyol 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine <=> H+ + hesperetin(1-) + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016210", "l": "naringenin-chalcone synthase activity", "d": ["Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247837", "l": "WNT ligands traffic to the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15988", "l": "formate + NAD(+) <=> CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22721", "l": "ATP + L-histidyl-[protein] => ADP + H(+) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3595175", "l": "Defective CHST3 does not transfer SO4(2-) to chondroitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42443", "l": "L-aspartate + NAD(+) <=> H(+) + iminosuccinate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853745", "l": "RET binds GFRA1,GFRA3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418858", "l": "RhoGTPase GEF's recruited to DCC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.22", "l": "\"coagulation factor IXa\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34900", "l": "malonyl-CoA + S-adenosyl-L-methionine => malonyl-CoA methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781840", "l": "ERCC6 binds stalled RNA Pol II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047894", "l": "flavonol 3-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H+ + quercetin 3-sulfate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008311", "l": "double-stranded DNA 3'-5' DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71803", "l": "acetate(out) + H(+)(out) = acetate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168891", "l": "Binding of NS1 to dsRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69148", "l": "H2O + O2 + spermine = H2O2 + NH4(+) + spermine monoaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016802", "l": "trialkylsulfonium hydrolase activity", "d": ["Catalysis of the hydrolysis of a thioether bond, -S-."]}, {"i": "EC:3.3.1.-", "l": "\"Thioether and trialkylsulfonium hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13463", "l": "2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+) => 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44758", "l": "6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851298", "l": "GPR143 binds L-Dopa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63114", "l": "AH2 + ascofuranone => A + ascofuranol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59542", "l": "butanoyl-CoA + CO2 => (2R)-ethylmalonyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004727", "l": "prenylated protein tyrosine phosphatase activity", "d": ["Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196964", "l": "RFK:Mg2+ phosphorylates RIB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.7", "l": "\"cellulose-polysulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48965", "l": "2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 => [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48916", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b = CMP + ganglioside GD1c + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709360", "l": "H2O2 reduces MetHb (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53097", "l": "4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0002061", "l": "pyrimidine nucleobase binding", "d": ["Binding to a pyrimidine nucleobase, an organic nitrogenous base with a pyrimidine skeleton."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75052", "l": "chenodeoxycholate(out) => chenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65404", "l": "butan-1-ol + hexanoyl-CoA = butyl hexanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10415", "l": "ADP-D-ribose + H2O <=> AMP + D-ribose 5-phosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37899", "l": "2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.42", "l": "\"tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15341", "l": "ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate", "d": []}, {"i": "EC:6.6.1.2", "l": "\"cobaltochelatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62602", "l": "5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156908", "l": "eEF1A:GTP:aminoacyl tRNA ternary complex formation. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48434", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] => ATP + N(6)-D-ribulosyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3782655", "l": "HDAC10 deacetylates histone (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16644", "l": "a long-chain fatty acyl ethyl ester + H2O <=> a long-chain fatty acid + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000513", "l": "actin severing activator activity", "d": ["Binds to and increases the activity of a actin severing protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428750", "l": "Gq activation by TP receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53825", "l": "NAD(+) + taurochenodeoxycholate => 7-oxotaurolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193786", "l": "3,7,24THCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25237", "l": "ATP + CDP = ADP + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31340", "l": "acetate + ATP + holo-[ACP] => acetyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72697", "l": "Start codon recognition (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54430", "l": "ADP-D-ribose + H(+) + L-aspartyl-[protein] => 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8856951", "l": "PP2A demethylation by PPME1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782820", "l": "USP17 deubiquitinates SUDS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018365", "l": "protein-serine epimerase activity", "d": ["Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17934", "l": "a 7-hydroxyisoflavone + S-adenosyl-L-methionine => a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21290", "l": "D-glucose 6-phosphate + glycerol => D-glucose + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615933", "l": "SUMOylation of CBX5 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21448", "l": "16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] = 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate", "d": []}, {"i": "EC:1.18.6.1", "l": "\"nitrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0005547", "l": "phosphatidylinositol-3,4,5-trisphosphate binding", "d": ["Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41491", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25843", "l": "5-deoxy-D-glucuronate <=> 5-dehydro-2-deoxy-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549304", "l": "OCT3 mediates renal clearance of organic cations (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210298", "l": "Interaction of DAP12 and KIR3DS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22362", "l": "5-oxo-D-proline + H2O => D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30834", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48769", "l": "ATP + D-erythrulose => ADP + D-erythrulose 4-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20539", "l": "(R)-4'-phosphopantetheine + apo-[ACP] + H(+) => H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50399", "l": "(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA <=> 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50398", "l": "2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O => (2-aminobenzoyl)acetate + H(+) + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55287", "l": "all-trans-retinol + tetradecanoyl-CoA <=> all-trans-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008478", "l": "pyridoxal kinase activity", "d": ["Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30710", "l": "putrescine + pyruvate <=> 4-aminobutanal + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24285", "l": "L-aspartate 4-semialdehyde + NADP(+) + phosphate => 4-phospho-L-aspartate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169394", "l": "ISGylation of IRF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46646", "l": "5beta-dihydrocortisol + NADP(+) => cortisol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36045", "l": "13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial => all-trans-8'-apo-beta-carotenal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2545253", "l": "Deacetylation of cohesin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807826", "l": "LDHAL6B reduces PYR to LACT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52650", "l": "5-phospho-L-arabinonate + H(+) => H2O + L-arabino-1,4-lactone 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690873", "l": "ACO1 binds 4Fe-4S (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70206", "l": "N-methyldopaminechrome <=> 5,6-dihydroxyindole-N-methyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70744", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74849", "l": "3-diphospho-1D-myo-inositol 1,2,4,5-tetrakisphosphate + ADP => 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177923", "l": "Sustained activation of SRC kinase by SHP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40767", "l": "(20S)-ginsenoside R1 + H2O = (20S)-ginsenoside Rg1 + D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707523", "l": "Hemes bind to BACH1:MAFK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047763", "l": "caffeate O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15806", "l": "(7R,8S)-7,8-diammoniononanoate + ATP + CO2 => (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265177", "l": "Exocyst complex formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17234", "l": "L-fucose => L-fuculose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.4", "l": "\"glutamate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23537", "l": "alpha-D-glucose 1-phosphate => alpha-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35375", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O = (beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53835", "l": "2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 <=> a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015663", "l": "nicotinamide mononucleotide transmembrane transporter activity", "d": ["Enables the directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10213", "l": "2-oxoglutarate + 5-aminopentanoate => 5-oxopentanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592398", "l": "Activation of proMMP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37949", "l": "12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661432", "l": "BIL binds ALB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53015", "l": "2,5-dichlorohydroquinone + 2 glutathione <=> chloride + chlorohydroquinone + glutathione disulfide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45884", "l": "12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34176", "l": "2-hydroxybenzoyl-CoA + malonyl-CoA => 4-hydroxycoumarin + CO2 + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1297444", "l": "Binding of cAMP to HCN channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46105", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => corticosterone + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701064", "l": "TRPV1 binds TRPV1 agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33371", "l": "alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] = alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.201", "l": "\"protein-N(pi)-phosphohistidine--trehalose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42149", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862184", "l": "USP48 cleaves polyubiquitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66178", "l": "ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out) => ATP + H2O + taurochenodeoxycholate 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35859", "l": "1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59053", "l": "D-lysine + H(+) => cadaverine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "56.385635569563355", "identifiers": [{"i": "GO:0005249", "l": "voltage-gated potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214860", "l": "CACT and DL/DIF dimer are phosphorylated in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672969", "l": "Phosphorylation of RAF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47273", "l": "monoanhydrobacterioruberin => bisanhydrobacterioruberin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0017099", "l": "very-long-chain-acyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11405", "l": "UDP-alpha-D-glucuronate => UDP-alpha-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67436", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34687", "l": "AH2 + N-acyl-15-methylhexadecasphinganine + O2 = A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24560", "l": "acetyl-CoA + L-serine = CoA + O-acetyl-L-serine", "d": []}, {"i": "EC:2.3.1.30", "l": "\"serine O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938108", "l": "SERPINB13 binds cathepsin L (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60836", "l": "a 5'-end diphospho-adenosine in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708557", "l": "FBXL17 binds BACH1:MAFK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350598", "l": "Arginine<=>Agmatine+CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68064", "l": "a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17204", "l": "2-dehydro-3-deoxy-L-arabinonate <=> 2,5-dioxopentanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047646", "l": "alkanal monooxygenase (FMN-linked) activity", "d": ["Catalysis of the reaction: R-CHO + reduced FMN + O2 = R-COOH + FMN + H2O + light."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63896", "l": "aspulvinone E + hnu = isoaspulvinone E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43870", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out) => a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067667", "l": "IL6 binds IL6R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694583", "l": "ABHD4 hydrolyses NAPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709109", "l": "DHFR dimer binds DHFR inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60363", "l": "FMN + H(+) + oxidized coenzyme F420-0 <=> dehydro coenzyme F420-0 + FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71195", "l": "H(+)(out) + Zn(2+)(out) = H(+)(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32670", "l": "coenzyme M + methanethiol <=> H(+) + hydrogen sulfide + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71025", "l": "L-leucine(out) + L-phenylalanine(in) => L-leucine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67358", "l": "(2S)-naringenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA => (2S)-naringenin 7-O-beta-D-glucoside + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60059", "l": "a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 <=> a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.2", "l": "\"(S)-2-haloacid dehalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28186", "l": "aminoacetone + H2O + O2 = H2O2 + methylglyoxal + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654163", "l": "Activated FGFR4 binds PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14599", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029989", "l": "Autocatalytic phosphorylation of overexpressed FGFR2 variants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17131", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate => ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62069", "l": "2-deoxy-D-glucose 6-phosphate + NADP(+) => 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70898", "l": "N-terminal L-cysteinyl-[protein] + O2 <=> H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111956", "l": "Calmodulin activates Cam-PDE 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3785684", "l": "Fibronectin degradation by CTSG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36859", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43037", "l": "L-cysteine => 2-aminoprop-2-enoate + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72460", "l": "fumarate(in) + L-aspartate(out) => fumarate(out) + L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67106", "l": "CO2 + H2O + novofumigatonin + succinate => 2-oxoglutarate + fumigatonoid C + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58636", "l": "N-(9Z-octadecenoyl)-(2S)-hydroxyglycine = (9Z)-octadecenamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56090", "l": "CMP + globoside DSGG + H(+) => CMP-N-acetyl-beta-neuraminate + globoside MSGG", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51802", "l": "adlupulone + diphosphate + H(+) => deoxyadlupulone + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050563", "l": "trans-feruloyl-CoA synthase activity", "d": ["Catalysis of the reaction: ATP + CoA + trans-ferulate = (E)-feruloyl-CoA + ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32111", "l": "S-adenosyl-L-methionine + trans-resveratrol = 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28898", "l": "cadaverine(in) + L-lysine(out) <=> cadaverine(out) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32703", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = 8-hydroxycopalyl diphosphate", "d": []}, {"i": "EC:4.2.1.133", "l": "\"copal-8-ol diphosphate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004908", "l": "interleukin-1 receptor activity", "d": ["Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45638", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43702", "l": "methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine => (2E,6E)-farnesoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42347", "l": "H(+) + NADH + O2 + p-cumate <=> (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444647", "l": "C3a receptor binds anaphylatoxin C3a (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419490", "l": "Binding of ATP to P2X receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983424", "l": "Budding of COPII coated vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69641", "l": "beta-D-glucose + phloretin => H2O + phlorizin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73141", "l": "lithocholate(in) => lithocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42496", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate = 10-deacetyl-2-debenzoylbaccatin III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63514", "l": "biphenyl-2,2',3-triol + H2O + NAD(+) => biphenyl-2,2'-diol + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42029", "l": "NAD(+) + ursodeoxycholate => 7-oxolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985594", "l": "MYO9B inactivates RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625424", "l": "The retrograde IFT train dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41517", "l": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45926", "l": "4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA => 9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19030", "l": "3 H(+) + H2O + urea-1-carboxylate => 2 CO2 + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43326", "l": "1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19070", "l": "(R)-S-lactoylglutathione => glutathione + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036402", "l": "proteasome-activating activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome."]}, {"i": "EC:5.6.1.5", "l": "\"proteasome ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047757", "l": "chondroitin-glucuronate 5-epimerase activity", "d": ["Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62352", "l": "H(+) + NADPH + notoamide E + O2 = H2O + NADP(+) + notoamide D", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.839897517610368", "identifiers": [{"i": "GO:0046915", "l": "transition metal ion transmembrane transporter activity", "d": ["Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624948", "l": "KIF17 enters the cilium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26500", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64968", "l": "dUTP + H2O = dUDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35998", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009558", "l": "IL34 dimer binds SDC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69137", "l": "2 H2O + 2 O2 + spermine => 2 H2O2 + 2 NH4(+) + spermine dialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42589", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047700", "l": "beta-glucoside kinase activity", "d": ["Catalysis of the reaction: ATP + cellobiose = ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57583", "l": "S-methyl-5-thio-D-ribulose 1-phosphate <=> S-methyl-1-thiol-D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8847880", "l": "CYTH proteins bind ARF1:GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41852", "l": "H(+) + malonyl-[ACP] + octanoyl-[ACP] = 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0017172", "l": "cysteine dioxygenase activity", "d": ["Catalysis of the reaction: L-cysteine + O2 = 3-sulfino-L-alanine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11697", "l": "3'-demethylstaurosporine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + staurosporine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419152", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate + pyrophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24120", "l": "H(+) + leukotriene E4 + NADPH + O2 = 20-hydroxy-leukotriene E4 + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.34", "l": "\"leukotriene-E4 20-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-481007", "l": "Exocytosis of platelet alpha granule contents (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102065", "l": "patchoulene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> diphosphoric acid + gamma-patchoulene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62614", "l": "H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine => adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14632", "l": "ATP + N-acetyl-L-glutamate <=> ADP + N-acetyl-L-glutamyl 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14139", "l": "6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60754", "l": "CoA + jasmolin I => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47718", "l": "21-hydroxyprogesterone + H(+) + NADH => 4-pregnen-20,21-diol-3-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56658", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH => 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048529", "l": "magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity", "d": ["Catalysis of the reaction: magnesium protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140999", "l": "histone H3K4 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = 2 H+ + N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211219", "l": "Translocation of caspase-3 to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16146", "l": "CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39848", "l": "a 2-acylglycerol + ATP => a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55512", "l": "cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034801", "l": "2,4-dinitrocyclohexanone hydrolase activity", "d": ["Catalysis of the reaction: 2,4-dinitrocyclohexanone + OH- = 4,6-dinitrohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938121", "l": "SERPINB13 binds CTSK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3640862", "l": "Tankyrase binds AXIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016711", "l": "flavonoid 3'-monooxygenase activity", "d": ["Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14464", "l": "(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose <=> (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50559", "l": "prostaglandin D2 <=> H2O + prostaglandin J2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64593", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21449", "l": "16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] => 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034647", "l": "histone H3K4me/H3K4me2/H3K4me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450550", "l": "PKCalpha phosphorylates HuR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59102", "l": "H(+) + triglucosyl-enterobactin + UDP => diglucosyl-enterobactin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67841", "l": "a lipid A disaccharide + ATP => a lipid IVA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.17", "l": "\"pro-opiomelanocortin converting enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51202", "l": "H2O + N-retinylidene-N-retinylphosphatidylethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0001648", "l": "proteinase-activated receptor activity", "d": ["A G protein-coupled receptor activity that is activated by cleavage by a serine protease, exposing a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2314678", "l": "ASA- acetylates PTGS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614618", "l": "Persulfide sulfur is transferred onto sulfite (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52516", "l": "trans-4-hydroxy-L-proline + ubiquinone-10 = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48995", "l": "1,3,7-trimethylurate + H(+) + NADH + O2 <=> 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25866", "l": "4-acetamidobutanal + H2O2 + propane-1,3-diamine => H2O + N(1)-acetylspermidine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5251942", "l": "Hikeshi binds HSP70s:ATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65369", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O => a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14170", "l": "ATP + CoA + glutarate => ADP + glutaryl-CoA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.219", "l": "\"demethoxycurcumin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27366", "l": "bromide + S-adenosyl-L-methionine => bromomethane + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75712", "l": "a rhodoquinone + succinate => a rhodoquinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016784", "l": "3-mercaptopyruvate sulfurtransferase activity", "d": ["Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49454", "l": "6-sulfo-alpha-D-quinovose + a 1,2-diacyl-sn-glycerol => a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372542", "l": "Loading of dopamine into synaptic veiscles (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48612", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": []}, {"i": "EC:2.8.1.11", "l": "\"molybdopterin synthase sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45701", "l": "glycine betaine + H(+) + NADH + O2 => formaldehyde + H2O + N,N-dimethylglycine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21336", "l": "NAD(+) + pyridoxal = 4-pyridoxolactone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.107", "l": "\"pyridoxal 4-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031810", "l": "H4 histamine receptor binding", "d": ["Binding to a H4 histamine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35545", "l": "3-hydroxypyruvate + phosphate => 3-phosphooxypyruvate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340214", "l": "CYGB binds O2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46498", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out) => N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17303", "l": "ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] => ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73377", "l": "biotin(in) + 2 Na(+)(in) => biotin(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193646", "l": "NGF binding to p75NTR inactivates RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69732", "l": "CoA + phenylacetyl-AMP => AMP + H(+) + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39870", "l": "3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol <=> 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879930", "l": "STAT5 is recruited by JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674531", "l": "AAMP binds EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22313", "l": "5-(methylsulfanyl)-D-ribose + ATP => ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64378", "l": "a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2 => 8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018534", "l": "nitrilotriacetate dehydrogenase activity", "d": ["Catalysis of the reaction: nitrilotriacetate + OH- = H+ + 2 e- + glyoxylate + iminodiacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762345", "l": "PREDN:ALB dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517731", "l": "Expression of IL-8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19783", "l": "3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + 3,5-diiodo-L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71903", "l": "guanine + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-guanine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19695", "l": "5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH => 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428749", "l": "Activated TP receptor binds G-proten Gq (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34191", "l": "(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73869", "l": "serotonin(in) => serotonin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34421", "l": "(+)-pinoresinol + H(+) + NADPH => (+)-lariciresinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.4.7", "l": "\"hydroperoxy icosatetraenoate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66995", "l": "3-methylpentanoate + ATP + CoA <=> 3-methylpentanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61781", "l": "keto-L-tagatose => keto-L-sorbose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13335", "l": "beta-D-fructose 2-phosphate + phosphate => beta-D-fructose 2,6-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16363", "l": "3-hydroxy-3-methyl-2-oxobutanoate => 2-acetolactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38472", "l": "L-histidine + 3 S-adenosyl-L-methionine => 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57243", "l": "glyoxal + GMP <=> N(2)-(1-hydroxy-2-oxoethyl)-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45594", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16547", "l": "formate + oxalyl-CoA => formyl-CoA + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047036", "l": "codeinone reductase (NADPH) activity", "d": ["Catalysis of the reaction: codeine + NADP+ = codeinone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060002", "l": "plus-end directed microfilament motor activity", "d": ["A motor activity that generates movement along a microfilament towards the plus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679205", "l": "ULK1 phosphorylates Beclin-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75172", "l": "Formation of RAD50:MRE11 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64414", "l": "H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) => H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51465", "l": "deoxycholate + O2 + reduced [NADPH--hemoprotein reductase] => 1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937613", "l": "CRHBP binds CRH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19651", "l": "AMP + diphosphate + L-aspartyl-tRNA(Asp) => ATP + L-aspartate + tRNA(Asp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23919", "l": "H(+) + UDP-alpha-D-glucuronate <=> CO2 + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11827", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985201", "l": "ABCE1 binds RNASEL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429955", "l": "CCR4-NOT complex deadenylates mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043740", "l": "GTP cyclohydrolase IIa activity", "d": ["Catalysis of the reaction: GTP + 3 H2O = 2-amino-5-formylamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + 3 H+ + 2 phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165680", "l": "Formation of active mTORC1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75704", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate => 14,15-epoxy-12-hydroxy-(10E)-eicosenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004071", "l": "aspartate-ammonia ligase activity", "d": ["Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64796", "l": "H2O + L-lysine + NADP(+) = (S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52008", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28212", "l": "(S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate => H2O + L-saccharopine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42539", "l": "uridine(65) in tRNA <=> pseudouridine(65) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051075", "l": "S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity", "d": ["Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683656", "l": "mRNA4 is translated to protein E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186780", "l": "PI3-kinase binds to the active receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020260", "l": "Hydroperoxy reducatse reduces 7(S)-Hp-17(S)-HDHA to RvD5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9006870", "l": "IL21 receptor STAT phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37198", "l": "octadecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17836", "l": "3-hydroxyanthranilate + S-adenosyl-L-methionine <=> 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043959", "l": "L-erythro-3-methylmalyl-CoA lyase activity", "d": ["Catalysis of the reaction: propionyl-CoA + glyoxylate = L-erythro-3-methylmalyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63319", "l": "(9Z,12Z)-octadecadienoate + O2 <=> 9-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12773", "l": "2-oxoglutarate + O2 + proclavaminate = CO2 + dihydroclavaminate + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799462", "l": "TP53 family members bind the TP53I3 (PIG3) gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35245", "l": "adenosine thiamine triphosphate + phosphate => ADP + H(+) + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784959", "l": "BPHL hydrolyses VACV to ACV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18457", "l": "D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)", "d": []}, {"i": "EC:4.1.99.12", "l": "\"3,4-dihydroxy-2-butanone-4-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349455", "l": "Phosphorylation of MDM4 by ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44686", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61791", "l": "ATP + holo-[peptidyl-carrier protein] + L-tryptophan <=> AMP + diphosphate + L-tryptophyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43789", "l": "acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O => ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33208", "l": "ATP + H(+) + L-glutamate + NADPH => ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810724", "l": "PI3 binds the bacterial surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50757", "l": "NADP(+) + reduced [flavodoxin] => 2 H(+) + NADPH + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043858", "l": "arginine:ornithine antiporter activity", "d": ["Catalysis of the reaction: arginine(out) + ornithine(in) = arginine(in) + ornithine(out)."]}, {"i": "RHEA:34991", "l": "L-arginine(out) + L-ornithine(in) = L-arginine(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:1990088", "l": "[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase", "d": ["Catalysis of the reaction: a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M = methyl-coenzyme M + a [Co(I) methanol-specific corrinoid protein] + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52174", "l": "11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30436", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.2.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9612219", "l": "ERBB4s80 binds to SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49033", "l": "(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] => 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69466", "l": "2 [thioredoxin]-disulfide + dimethylarsinous acid + 3 glutathione + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 [thioredoxin]-dithiol + arsenic triglutathione + H2O + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2059926", "l": "NPHP4 protein binds LATS proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74848", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + ATP => 3-diphospho-1D-myo-inositol 1,2,4,5-tetrakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39273", "l": "(2E,15Z)-tetracosadienoyl-CoA + H2O => (3R)-hydroxy-(15Z)-tetracosenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58897", "l": "4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59155", "l": "ATP + CoA + pseudomonate C <=> AMP + diphosphate + pseudomonoyl-CoA C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29311", "l": "FMNH2 + O2 + sulfoacetate = FMN + glyoxylate + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32707", "l": "(2E)-geranyl diphosphate = (2R,4S)-bornyl diphosphate", "d": []}, {"i": "EC:5.5.1.22", "l": "\"(-)-bornyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27303", "l": "7-chloro-L-tryptophan + O2 => 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64841", "l": "2-phenylethanol + benzoyl-CoA => CoA + phenethyl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30290", "l": "15-cis-phytoene + 2 a plastoquinone <=> 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63488", "l": "9,10-phenanthroquinone + H(+) + NADPH = NADP(+) + phenanthrene-9,10-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102128", "l": "chalcone synthase activity", "d": ["Catalysis of the reaction: 4-dihydrocoumaroyl-CoA + 3 malonyl-CoA + 3 H+ = phloretin + 4 coenzyme A + 3 carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18125", "l": "A + a D-alpha-amino acid + H2O = a 2-oxocarboxylate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23578", "l": "berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112149", "l": "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60299", "l": "L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55600", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44194", "l": "2-methylhexadecanoyl-CoA + AMP + diphosphate => 2-methylhexadecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17735", "l": "CO2 + pyruvate => acetylenedicarboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38016", "l": "delta-tocotrienol => 6-geranylgeranyl-2-methylbenzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705926", "l": "AR binds AR agonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168459", "l": "Lyn activates ERK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9603784", "l": "PEX19:class I PMP binds PEX3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47150", "l": "1,3,7-trimethylurate + a ubiquinol => a ubiquinone + caffeine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021950", "l": "MECP2 binds MEF2C gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70204", "l": "N-methyldopaminechrome => 5,6-dihydroxyindole-N-methyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5159250", "l": "ATF7IP binds SETDB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980041", "l": "NOTCH1 binds DLL4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10665", "l": "NAD(+) + perillyl alcohol => H(+) + NADH + perillyl aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64924", "l": "dATP + 2 H2O = dAMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64969", "l": "dUTP + H2O => dUDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22782", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15393", "l": "(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate", "d": []}, {"i": "EC:5.1.1.7", "l": "\"diaminopimelate epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052870", "l": "tocopherol omega-hydroxylase activity", "d": ["Catalysis of the reaction: tocopherol + O2 + NADPH + H+ = 13'-hydroxy-tocopherol + NADP+ + H2O ."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53617", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-isoafricanol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70993", "l": "H(+)(out) + L-mannopyranose(out) => H(+)(in) + L-mannopyranose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74901", "l": "(2E)-butenoyl-[ACP] + AMP + diphosphate => (2E)-2-butenoate + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66739", "l": "ATP + beta-citrylglutamate(in) + H2O <=> ADP + beta-citrylglutamate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909552", "l": "Phosphorylation of STAT1 at Ser727 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30350", "l": "ATP + IDP <=> ADP + ITP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29758", "l": "(R)-lipoate(in) <=> (R)-lipoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55199", "l": "2-hydroxyoctadecanoyl-CoA <=> formyl-CoA + heptadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111264", "l": "Addition of nucleotides between position +11 and +30 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18342", "l": "D-xylono-1,4-lactone + H2O => D-xylonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64319", "l": "2 dihydrogeodin + 2 H(+) + O2 <=> 2 (+)-geodin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989758", "l": "Expression of UGT1A9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69487", "l": "dodecan-1-ol + O2 <=> dodecanal + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2562541", "l": "TLR4-induced ripoptosome assembly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16838", "l": "5'-acylphosphoadenosine + H2O => a carboxylate + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434650", "l": "MATEs mediate extrusion of xenobiotics (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9680443", "l": "ROCK1,2 bind ROCKi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0050524", "l": "coenzyme-B sulfoethylthiotransferase activity", "d": ["Catalysis of the reaction: coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane. Methyl-CoM is also known as 2-(methylthio)ethanesulfonate, coenzyme B as N-(7-mercaptoheptanoyl)threonine 3-O-phosphate, and coenzyme M-coenzyme B heterodisulfide as CoM-S-S-CoB."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110218", "l": "Cleavage of uracil by TDG glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28800", "l": "H2O + L-prolinylglycine => glycine + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59201", "l": "ATP + docosanoate + H(+) => diphosphate + docosanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76101", "l": "a dicarboxylate(out) + xanthurenate(in) => a dicarboxylate(in) + xanthurenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951727", "l": "cAMP binds PKA tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12386", "l": "H2O2 + uracil => 5,6-dihydrouracil + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71582", "l": "CDP(out) + CDP-L-ribitol(in) <=> CDP(in) + CDP-L-ribitol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35773", "l": "3-amino-5-hydroxybenzoate + H(+) + H2O => 5-deoxy-5-amino-3-dehydroshikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68929", "l": "ATP + H(+) + heptanoate + NADPH => AMP + diphosphate + heptanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982792", "l": "Growth hormone receptor binds JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67920", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201717", "l": "CSNK2-mediated phosphorylation of DVL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15125", "l": "acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) = CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}, {"i": "EC:2.3.1.78", "l": "\"heparan-alpha-glucosaminide N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15065", "l": "H2O + N(4)-benzoylagmatine = agmatine + benzoate", "d": []}, {"i": "EC:3.5.1.40", "l": "\"acylagmatine amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74746", "l": "kaempferol + S-adenosyl-L-methionine <=> 3-O-methylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103020", "l": "1-deoxy-D-xylulose kinase activity", "d": ["Catalysis of the reaction: 1-deoxy-D-xylulose + ATP <=> H+ + 1-deoxy-D-xylulose 5-phosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603445", "l": "Activated NTRK3 stimulates PI3K activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483089", "l": "PE is converted to PS by PTDSS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11942", "l": "CO2 + L-ornithine + NH4(+) => 2 H(+) + H2O + L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74578", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] <=> N(alpha)-acetyl-L-methionine + N-terminal L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30702", "l": "2-oxoglutarate + beta-alanine <=> 3-oxopropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15514", "l": "ATP + keto-D-tagatose => ADP + H(+) + keto-D-tagatose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55321", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59247", "l": "3''-O-acetyl-ADP-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003908", "l": "methylated-DNA-[protein]-cysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651789", "l": "LIG1 bound to POLB ligates SSB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784861", "l": "HSPG binds LPL dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445704", "l": "Calcium Binds Caldesmon (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72552", "l": "glutarate(out) + urate(in) => glutarate(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75278", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate <=> (10R,11R)-epoxy-(9S)-hydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047875", "l": "ecdysone oxidase activity", "d": ["Catalysis of the reaction: Ecdysone + O2 = 3-dehydroecdysone + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30495", "l": "N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43841", "l": "26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000120", "l": "CBLIF binds RCbl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75540", "l": "(2E)-decenoate + ATP + holo-[ACP] => (2E)-decenoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247836", "l": "Retromer recycles WLS to the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174157", "l": "Degradation of multiubiquitinated Cyclin B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28805", "l": "3-dehydro-L-gulonate 6-phosphate => H2O + L-ascorbate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871260", "l": "YAP1 binds TEAD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3782655", "l": "HDAC10 deacetylates histone (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62998", "l": "(8Z,11Z,14Z)-eicosatrienoate + NH4(+) => (8Z,11Z,14Z)-eicosatrienamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69152", "l": "Removal of remaining Flap (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9650858", "l": "Meglitinides bind ABCC8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65656", "l": "A + cholest-1,4-dien-3-one + H2O = 25-hydroxycholest-1,4-dien-3-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72139", "l": "estrone 3-sulfate(in) + H(+)(out) = estrone 3-sulfate(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73469", "l": "beta-alanine + dopamine => beta-alanyl-dopamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44400", "l": "3-demethylubiquinol-6 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21989", "l": "malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside => 4'''-demalonylsalvianin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55516", "l": "11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] = 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44478", "l": "1-O-alkyl-2-acetyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29597", "l": "H(+) + NADPH + sulfoacetyl-CoA => CoA + NADP(+) + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74785", "l": "tyramine(out) => tyramine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11376", "l": "(19E)-geissoschizine + NADP(+) = 4,21-dehydrogeissoschizine + NADPH", "d": []}, {"i": "EC:1.3.1.36", "l": "\"geissoschizine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62011", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042912", "l": "colicin transmembrane transporter activity", "d": ["Enables the transfer of a colicin from one side of a membrane to the other. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69053", "l": "RFC binding displaces Pol Alpha (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432010", "l": "Aquaporin-1 passively transports water into cell (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31966", "l": "9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047569", "l": "3-oxoadipate CoA-transferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052714", "l": "mannosyl-inositol phosphorylceramide phospholipase activity", "d": ["Catalysis of the reaction: mannosyl-inositol phosphorylceramide + H2O = C26-phytoceramide + mannosylphosphorylinositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22183", "l": "(S)-norreticuline + S-adenosyl-L-methionine <=> (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183051", "l": "CBL ubiquitinates Sprouty (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187382", "l": "Degradation of ubiquitinated SMAD3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13455", "l": "adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate => 3'-phosphoadenylyl sulfate + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56665", "l": "7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68948", "l": "esculetin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34377", "l": "4-guanidinobutanoate + NH4(+) => 4-guanidinobutanamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19082", "l": "1-haloalkane + H2O => a halide anion + a primary alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64460", "l": "acetyl phosphate + L-lysyl-[protein] = H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65124", "l": "benzoyl-CoA + ethanol = benzyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30712", "l": "(S)-linalool => beta-myrcene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55192", "l": "2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 = 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.15", "l": "\"N(8)-acetylspermidine oxidase (propane-1,3-diamine-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58662", "l": "a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine => a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821368", "l": "AKAP8L binds MLL1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63569", "l": "beta-casomorphin-7 + H2O => beta-casomorphin-6 + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392751", "l": "L1 linked to actin cytoskeleton by ankyrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58628", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV = FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24260", "l": "(3E)-2-oxohex-3-enedioate + H(+) = 2-oxopent-4-enoate + CO2", "d": []}, {"i": "EC:4.1.1.77", "l": "\"2-oxo-3-hexenedioate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-500366", "l": "LIN28 binds POU5F1 (OCT4) mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21198", "l": "L-methionine + tetrahydropteroyltri-L-glutamate => 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10472", "l": "(2R,3S)-2,3-dimethylmalate = propanoate + pyruvate", "d": []}, {"i": "EC:4.1.3.32", "l": "\"2,3-dimethylmalate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2172666", "l": "RB1 binds condensin II (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73945", "l": "FAS-mediated dimerization of procaspase-8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047151", "l": "methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH + H+ = tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40007", "l": "(+)-copalyl diphosphate + H2O = (+)-copalol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156682", "l": "PLK1 phosphorylates NUDC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19291", "l": "phosphate + sucrose => H2O + sucrose 6(F)-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52956", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate = hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38644", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106151", "l": "CNBH domain intrinsic ligand binding", "d": ["Interacting selectivity and noncovalently with a cyclic nucleotide mimicking protein motif that is part of the same protein. The CNBHD is a domain on KCNH channels that creates a binding pocket on the KCNH channel that resembles the cyclic nucleotide- binding domain on other ion channels. It binds to a peptide motif that is part of the same protein rather than a cyclic nucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62046", "l": "(9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33572", "l": "A + methanol => AH2 + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13819", "l": "2,3-epoxyphylloquinone + [protein]-dithiol => [protein]-disulfide + H2O + phylloquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.32", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19191", "l": "(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2 => (R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008930", "l": "methylthioadenosine nucleosidase activity", "d": ["Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.91", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196417", "l": "Reduction of desmosterol to cholesterol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56579", "l": "globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine <=> globoside Gb4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169895", "l": "Crk's SH3 domain engages C3G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514865", "l": "cGMP dissociates from CNG channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873794", "l": "PCTP binds PC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46196", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23699", "l": "myo-inositol + O2 <=> D-glucuronate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.13", "l": "\"IgA-specific metalloendopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49502", "l": "GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+) => 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63763", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034876", "l": "isonicotinic acid hydrazide hydrolase activity", "d": ["Catalysis of the reaction: isoniazid + H2O = isonicotinate + hydrazine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69610", "l": "acetyl-CoA + N-terminal L-methionyl-[tubulin] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57191", "l": "H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] <=> glycolate + H(+) + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67101", "l": "fumigatonoid B => fumigatonoid C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-170159", "l": "Translocation of Cdc25 to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12994", "l": "cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042835", "l": "BRE binding", "d": ["Binding to a BRE RNA element (Bruno response element)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473594", "l": "Collagen type II degradation by MMP15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1912357", "l": "ITCH ubiquitinates DTX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39703", "l": "(2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH = (13Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.34", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0008990", "l": "rRNA (guanine-N2-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6795290", "l": "TORC2 complex phosphorylates SGK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71240", "l": "2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH => 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43193", "l": "cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine => 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25326", "l": "N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine => H(+) + phosphocholine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0046572", "l": "versicolorin B synthase activity", "d": ["Catalysis of the reaction: versiconal = versicolorin B + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990247", "l": "N6-methyladenosine-containing RNA binding", "d": ["Binding to an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432164", "l": "Ca2+ influx into the post-synaptic cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2995334", "l": "COX15 transforms heme O to heme A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28885", "l": "H(+)(out) + L-threonine(out) => H(+)(in) + L-threonine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0047850", "l": "diaminopimelate dehydrogenase activity", "d": ["Catalysis of the reaction: meso-2,6-diaminopimelate + H2O + NADP+ = L-2-amino-6-oxopimelate + H+ + NADPH + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36461", "l": "glycine + L-proline => glycyl-L-proline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.92", "l": "\"endopeptidase Clp\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35235", "l": "H(+)(out) + tetracycline(in) = H(+)(in) + tetracycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202500", "l": "Activation of IKK complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44701", "l": "a 2,3-saturated acyl-CoA + FAD + H(+) => a (2E)-enoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018807", "l": "RAC3 GDIs block activation of RAC3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731031", "l": "SARS-CoV-1 6 binds to NPIPB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013006", "l": "RHOA:GTP translocates to the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031826", "l": "type 2A serotonin receptor binding", "d": ["Binding to a type 2A serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34031", "l": "2'-N-acetylparomamine + H2O = acetate + paromamine", "d": []}, {"i": "EC:3.5.1.112", "l": "\"2'-N-acetylparomamine deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48610", "l": "a 2,3-dehydroacyl-CoA + AH2 => A + a 2,3-saturated acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19302", "l": "histamine + S-adenosyl-L-methionine => H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156699", "l": "Inactivation of Wee1 kinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.23", "l": "\"sugar-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237119", "l": "Acireductone is oxidized to MOB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34432", "l": "(+)-secoisolariciresinol + NADP(+) => (-)-lariciresinol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18161", "l": "acetyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CoA", "d": []}, {"i": "EC:2.3.1.155", "l": "\"acetyl-CoA C-myristoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74892", "l": "CO2(out) => CO2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619376", "l": "CAMK1 binds calmodulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55858", "l": "all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019150", "l": "D-ribulokinase activity", "d": ["Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687625", "l": "ATP binds MLKL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004088", "l": "carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990312", "l": "type-II cohesin domain binding", "d": ["Binding to a type-II cohesin domain of a protein. Type-II cohesin domain is the binding partner of type-II dockerin domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59763", "l": "apigenin + UDP-alpha-D-glucose <=> apigenin 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18415", "l": "a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17718", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP => 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64898", "l": "2 H(+) + 2 phosphate + UMP => 2 H2O + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419166", "l": "GEFs activate RhoA,B,C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13644", "l": "H(+) + methane + NADPH + O2 <=> H2O + methanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608866", "l": "VANGL2 is required for asymmetric membrane localization of FZD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28734", "l": "H(+)(out) + L-leucine(in) <=> H(+)(in) + L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44843", "l": "(R)-carnitine + octadecanoyl-CoA <=> CoA + O-octadecanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15954", "l": "agmatine + ATP => ADP + 2 H(+) + N(4)-phosphoagmatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662466", "l": "XYLB phosphorylates D-xylulose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54690", "l": "2-aminoprop-2-enoate + allylsulfenate => alliin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.967140482697559", "identifiers": [{"i": "GO:0008146", "l": "sulfotransferase activity", "d": ["Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30071", "l": "acetyl-CoA + butanoate = acetate + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9631296", "l": "NR1H2,3 binds the FABP6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798372", "l": "ATM phosphorylates DYRK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17539", "l": "(R)-carnitine + NH4(+) => (R)-carnitinamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70957", "l": "H(+)(out) + L-glutamate(out) => H(+)(in) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60074", "l": "4beta-hydroxymethyl-4alpha-methylzymosterol + H2O + NAD(+) => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39134", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72213", "l": "(1S,4S)-camphor + H(+) + NADH => (+)-isoborneol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48517", "l": "1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193981", "l": "CYP21A2 oxidises 17HPROG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47206", "l": "16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12685", "l": "2 mycothiol + NADP(+) = H(+) + mycothione + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102133", "l": "limonene hydroxylase activity", "d": ["Catalysis of the reaction: (4R)-limonene + O2 + NADH + H+ <=> (4R)-perillyl alcohol + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9698844", "l": "MLKL binds HSP90:CDC37 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46785", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444661", "l": "HCAR2 binds HCAR2 ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39036", "l": "an omega-hydroxy fatty acid + NAD(+) => an omega-oxo fatty acid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37655", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75714", "l": "a rhodoquinone + succinate <=> a rhodoquinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008444", "l": "CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22606", "l": "D-fructose => D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189069", "l": "sucrose + H2O => glucose + fructose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39678", "l": "(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63952", "l": "a sphingoid 1-phosphate + H2O = a sphingoid base + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41937", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose => a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875531", "l": "MET binds TNS4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534388", "l": "Progesterone Activation Of CatSper (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606682", "l": "MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35465", "l": "5alpha-cholest-7-en-3-one + H(+) + NADH => lathosterol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70499", "l": "D-galactose(out) + 2 Na(+)(out) = D-galactose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62649", "l": "(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 => (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430158", "l": "p-SLP-76 binds VAV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34444", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose => CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35690", "l": "NADP(+) + tetradecasphinganine <=> 3-oxotetradecasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2993802", "l": "HLCS biotinylates PC:Mn2+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51305", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44555", "l": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O <=> H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48923", "l": "ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75265", "l": "3'-dehydroisovitexin + H2O2 => isovitexin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45696", "l": "N-(acetyl)-sphing-4-enine-1-phosphate(in) = N-(acetyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043918", "l": "cadaverine aminopropyltransferase activity", "d": ["Catalysis of the reaction: S-adenosylmethioninamine + cadaverine = 5'-methylthioadenosine + N-(3-aminopropyl)cadaverine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983427", "l": "Expression of peptide bound class I MHC on cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73128", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine => 4',8-dihydroxy-7-methoxyflavone + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003992", "l": "N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24458", "l": "alpha-ribazole + phosphate => alpha-ribazole 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23220", "l": "4-chlorobenzoate + ATP + CoA = 4-chlorobenzoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.33", "l": "\"4-chlorobenzoate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018594", "l": "tert-butanol 2-monooxygenase activity", "d": ["Catalysis of the reaction: tert-butanol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351849", "l": "Caspase-mediated cleavage of Etk (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43636", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}, {"i": "EC:2.3.1.286", "l": "\"protein acetyllysine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47971", "l": "ganglioside GM2 + H2O <=> ganglioside GM3 + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14244", "l": "3-amino-4-hydroxybenzaldehyde + acetyl-CoA <=> 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23327", "l": "2'-phospho-[ligated tRNA] + NAD(+) <=> ADP-alpha-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43879", "l": "3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA <=> 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031780", "l": "corticotropin hormone receptor binding", "d": ["Binding to a corticotropin hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "78.958976004066542", "identifiers": [{"i": "GO:0015925", "l": "galactosidase activity", "d": ["Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14638", "l": "3'-phosphoadenylyl sulfate + a thiol => adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11350", "l": "ADP + arsenite(out) + H(+) + phosphate => arsenite(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54234", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-dioctanoyl-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47057", "l": "4alpha-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090595", "l": "acetyl-CoA:L-lysine N6-acetyltransferase", "d": ["Catalysis of the reaction: L-lysine + acetyl-CoA = N6-acetyl-L-lysine + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21830", "l": "2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72820", "l": "L-ornithine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) => L-ornithine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610802", "l": "GluN3A (GRIN3A), GluN3B (GRIN3B) NMDA receptors traffic to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34331", "l": "H(+) + indole-3-pyruvate + NADPH + O2 = (indol-3-yl)acetate + CO2 + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.168", "l": "\"indole-3-pyruvate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429694", "l": "CERT1-2 dissociates from the endoplasmic reticulum (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63426", "l": "(2S)-lactyl-2-diphospho-5'-guanosine + diphosphate => (2S)-2-phospholactate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350359", "l": "RHO1:GDP complex dissociates from RHOGDI and binds to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173709", "l": "C7 binds C5b:C6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42762", "l": "(2R)-3-phosphoglycerate + 2 H(+) + NADH => D-glyceraldehyde 3-phosphate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72380", "l": "chloride(out) + iodide(in) => chloride(in) + iodide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624365", "l": "Expression of PLTP regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74977", "l": "a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + H(+) => a (3R)-3-isocyanyl-fatty acyl-AMP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37063", "l": "2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53084", "l": "[(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21666", "l": "4-nitrophenol + H(+) + phosphate => 4-nitrophenyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14120", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O <=> [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23734", "l": "ADP + CO2 + isopentenyl diphosphate + phosphate => (R)-5-diphosphomevalonate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0009976", "l": "tocopherol cyclase activity", "d": ["Catalysis of the reaction: alkene group + alcohol group on same molecule = cyclic ether. Substrates are 2-methyl-6-phytyl-1,4- hydroquinone (forms delta-tocopherol) and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (forms gamma-tocopherol)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47860", "l": "ganglioside GT1b (d18:1(4E)) + H2O = ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696357", "l": "LAIR2 binds collagen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032761", "l": "DOCK3 binds FYN associated with NTRK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350578", "l": "NQO1 interaction with ODC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21761", "l": "(3S)-3-hydroxybutanoyl-CoA => (3R)-3-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9017491", "l": "RHOJ GEFs activate RHOJ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62891", "l": "GDP-beta-L-fucose + lactose <=> beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17542", "l": "an aromatic primary alcohol + O2 => an aromatic aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66760", "l": "ATP + H2O + kainate(in) = ADP + H(+) + kainate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657649", "l": "ALKBH2 binds alkylated DNA containing 1-etA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17986", "l": "4-(trimethylamino)butanal + H2O + NAD(+) => 4-(trimethylamino)butanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57678", "l": "4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14160", "l": "H2O + triphosphate <=> diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56735", "l": "4,4-dihydroxy-all-trans-beta-carotene <=> echinenone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.89", "l": "\"4'-methoxyisoflavone 2'-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210273", "l": "Interaction of DAP12 and NKp44 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3857336", "l": "CEBPB homodimerization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67702", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+) => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55233", "l": "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 Fe(III)-[cytochrome b561] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191299", "l": "Squalene is oxidized to its epoxide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624956", "l": "PDE6D binds INPP5E (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380316", "l": "Association of NuMA with microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71595", "l": "2-oxoglutarate(out) + succinate(in) = 2-oxoglutarate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033423", "l": "CCA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CCA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55949", "l": "A + D-alanine + H2O => AH2 + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015513", "l": "high-affinity secondary active nitrite transmembrane transporter activity", "d": ["Catalysis of the transfer of nitrite from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41430", "l": "3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine => L-tyrosine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28101", "l": "ATP + GDP <=> AMP + guanosine 3',5'-bis(diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43202", "l": "2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42777", "l": "adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58993", "l": "(E)-cinnamaldehyde + H2O + O2 => (E)-cinnamate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68960", "l": "DNA polymerase epsilon binds at the origin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55376", "l": "2 a quinol + O2 = 2 a quinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71369", "l": "epiandrosterone 3-sulfate(in) + 2 Na(+)(in) => epiandrosterone 3-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0050833", "l": "pyruvate transmembrane transporter activity", "d": ["Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-372342", "l": "MPC1:MPC2 cotransports PYR, H+ from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47758", "l": "2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139893", "l": "Granzyme-B activates BID by cleavage (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68677", "l": "3'-phosphoadenylyl sulfate + estrone 3-O-(beta-D-glucuronate) => adenosine 3',5'-bisphosphate + estrone 3-O-(3-sulfo-beta-D-glucuronate) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951500", "l": "Dissociation of CANX from nonameric complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16153", "l": "an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27656", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2 => 2-oxobutanoate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57308", "l": "CTP + H(+) + N(5)-phospho-L-glutamine = diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine", "d": []}, {"i": "EC:2.7.7.103", "l": "\"L-glutamine-phosphate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68941", "l": "Na(+)(in) + tellurite(in) => Na(+)(out) + tellurite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647632", "l": "CASP3 cleaves GSDME (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37838", "l": "aklavinone + H(+) + NADPH + O2 <=> epsilon-rhodomycinone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29543", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}, {"i": "EC:2.4.1.256", "l": "\"dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45723", "l": "N-hexadecanoylsphing-4-enine(in) <=> N-hexadecanoylsphing-4-enine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43695", "l": "ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] <=> AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29177", "l": "2 H(+) + 2 superoxide + ubiquinone-8 => 2 O2 + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429157", "l": "ABCC4 accumulation of dense granule contents (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416562", "l": "p190RhoGAP binds Plexin-B1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13842", "l": "Fe(II)2-[transferrin] + H(+) + NAD(+) => Fe(III)2-[transferrin] + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51570", "l": "(25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1433415", "l": "Activation of RAC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45393", "l": "H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202724", "l": "P-selectin binds P-selectin ligand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102678", "l": "22-alpha-hydroxy-campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity", "d": ["Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + NADP <=> H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52404", "l": "3-dehydro-4-O-phospho-L-erythronate + H(+) = CO2 + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035302", "l": "ecdysteroid 25-hydroxylase activity", "d": ["Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72517", "l": "(R)-carnitine(in) + glutarate(out) => (R)-carnitine(out) + glutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10669", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) => 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67346", "l": "CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside) => kaempferol 7-O-beta-D-glucoside + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62505", "l": "3-amino-5-hydroxybenzoate + ATP + holo-[aryl-carrier protein] => 3-amino-5-hydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350901", "l": "Iodide is organified (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18992", "l": "H(+) + L-valine <=> 2-methylpropan-1-amine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48549", "l": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O => [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42478", "l": "2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate => 2,2',3-trihydroxydiphenyl ether + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093332", "l": "p-EPHB phosphorylates SDC2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56304", "l": "ATP + H2O + rifampicin = 21-phosphorifampicin + AMP + 2 H(+) + phosphate", "d": []}, {"i": "EC:2.7.9.6", "l": "\"rifampicin phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36241", "l": "1-O-alkyl-2-acyl-sn-glycerol + phosphate => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37112", "l": "(15Z)-tetracosenoyl-CoA + sphing-4-enine => CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45417", "l": "11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O => 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.77", "l": "\"mannan 1,2-(1,3)-alpha-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15258", "l": "D-threonine => acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671772", "l": "p-T38-PPP1R14A binds MLCP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17389", "l": "D-arabinitol + NAD(+) = D-ribulose + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.250", "l": "\"D-arabinitol 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354087", "l": "Recruitment of GRB2 to p-PTK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52961", "l": "hyocholate + UDP-alpha-D-glucuronate => hyocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59395", "l": "acetyl-CoA + L-seryl-[protein] <=> CoA + O-acetyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63768", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50165", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15237", "l": "2 Fe(III)-[cytochrome c2] + NADPH = 2 Fe(II)-[cytochrome c2] + H(+) + NADP(+)", "d": []}, {"i": "EC:1.6.2.5", "l": "\"NADPH--cytochrome-c2 reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66699", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66450", "l": "(E)-2-pentenal + H(+) + NADPH => (E)-pent-2-en-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72130", "l": "agmatine(in) + H(+)(out) <=> agmatine(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71164", "l": "homogentisate + O2 => maleylacetoacetate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466238", "l": "BGN binds Collagen types II, III (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614271", "l": "Autocleavage of ADGRG6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42708", "l": "guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.33", "l": "\"tRNA (guanine(46)-N(7))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59365", "l": "1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008012", "l": "structural constituent of adult chitin-based cuticle", "d": ["The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of an adult organism. An example of this is found in Drosophila melanogaster."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2169046", "l": "Degradation of TGF-beta receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070551", "l": "endoribonuclease activity, cleaving siRNA-paired mRNA", "d": ["Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18556", "l": "(2R,3S)-tartrate + NAD(+) <=> dihydroxyfumarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390909", "l": "HRH2 binds hist (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53505", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine => 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209828", "l": "Tryptophan is hydroxylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71681", "l": "H(+)(in) + L-lysyl-glycine(in) => H(+)(out) + L-lysyl-glycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22430", "l": "2 H2O + isopenicillin N => N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26453", "l": "CoA + NADP(+) + succinate semialdehyde <=> H(+) + NADPH + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28177", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate <=> colneleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50032", "l": "H2O + hexadecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750666", "l": "ALB binds ST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20516", "l": "2-aryl-2-methylmalonate + H(+) <=> 2-arylpropionate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52733", "l": "3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate => adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26306", "l": "2-aminophenol + O2 => 2-aminomuconate 6-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29867", "l": "AMP + ITP = ADP + IDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39123", "l": "(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O = (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782296", "l": "DUS2:EPRS reduces uridine to dihydrouridine in tRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009541", "l": "ESR1 binds to TFF1 gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62375", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29802", "l": "ATP + D-allose(out) + H2O <=> ADP + D-allose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674018", "l": "BRAP binds RAS:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38005", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17276", "l": "(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) <=> 4-hydroxyphenylacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59647", "l": "D-xylobiono-1,5-lactone + H2O <=> D-xylobionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23450", "l": "CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate => 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870465", "l": "RGGT binds the RAB-binding subunit (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473186", "l": "FSTL3 binds Activin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40095", "l": "26-oxohexacosanoate + H2O + NAD(+) = 2 H(+) + hexacosanedioate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371591", "l": "Trimerization of cytosolic HSF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45727", "l": "(E)-4-coumaroyl alcohol + NADP(+) <=> (E)-4-coumaraldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0001716", "l": "L-amino-acid oxidase activity", "d": ["Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13023", "l": "3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+) => H(+) + NADH + O2 + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41936", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44659", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28361", "l": "FAD + H(+) + tetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134962", "l": "DHX36 binds DNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38202", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708557", "l": "FBXL17 binds BACH1:MAFK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72153", "l": "estrone 3-sulfate(in) + glutarate(out) => estrone 3-sulfate(out) + glutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15611", "l": "5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+) => ATP + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848829", "l": "CBL autoubiquitinates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11082", "l": "phosphate + thymidine => dTMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21819", "l": "a D-alpha-amino acid + H2O + O2 <=> a 2-oxocarboxylate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177922", "l": "EGFR dimerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869568", "l": "NPM1 binds TFAP2A homodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22001", "l": "D-xylose + NADP(+) => D-xylono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693608", "l": "Initial resection of double-strand break ends (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16915", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102477", "l": "2,5,7-trihydroxyflavanone 6C-glucoside dehydratase activity", "d": ["Catalysis of the reaction: 6C-glucosyl-2,5,7-trihydroxyflavanone <=> H+ + 6C-hexosyl chrysin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72680", "l": "(R)-dihydrolipoate + ATP + L-lysyl-[lipoyl-carrier protein] => (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203712", "l": "eNOS associates with Caveolin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70034", "l": "6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13779", "l": "5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate => ATP + D-ribose 5-phosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610752", "l": "GLI3R translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977363", "l": "Factor H binds to C3bBb (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43837", "l": "cholesterol + H(+) + NADPH + O2 => 26-hydroxycholesterol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019869", "l": "chloride channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a chloride channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448741", "l": "IL22RA2 binds IL22 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14981", "l": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031723", "l": "CXCR4 chemokine receptor binding", "d": ["Binding to a CXCR4 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1467466", "l": "ABCA4 mediates atRAL transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936963", "l": "IRAK2 induces TRAF6 oligomerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63891", "l": "hexadecanoyl-CoA + sphinga-4E,14Z-dienine <=> CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28989", "l": "H(+)(out) + N-acetylneuraminate(out) => H(+)(in) + N-acetylneuraminate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67705", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031813", "l": "P2Y2 nucleotide receptor binding", "d": ["Binding to a P2Y2 nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63295", "l": "N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432010", "l": "Aquaporin-1 passively transports water into cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220985", "l": "NOTCH1 PEST domain mutants stimulate MYC transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75672", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate => 14,15-epoxy-12-hydroxy-(10E,17Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672948", "l": "MARK3 phosphorylates KSR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222237", "l": "SMYD2 methylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102671", "l": "6a-hydroxymaackiain-3-O-methyltransferase activity", "d": ["Catalysis of the reaction: (+)-6a-hydroxymaackiain + S-adenosyl-L-methionine <=> H+ + (+)-pisatin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58618", "l": "glyoxylate + octanamide => N-octanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65332", "l": "H(+) + NADPH + O2 + verruculide A = chrodrimanin E + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46137", "l": "aminopyrrolnitrin + H(+) + NADPH + 2 O2 => 2 H2O + NADP(+) + pyrrolnitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634834", "l": "ACHEIs bind ACHE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48874", "l": "a gentamycin 2''-phosphate + GDP + H(+) => a gentamycin + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941312", "l": "TUT4,TUT7 oligouridylate mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25638", "l": "H2O + NAD(+) + sulfoacetaldehyde => 2 H(+) + NADH + sulfoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44157", "l": "1D-myo-inositol 5-phosphate + H2O => myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36836", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23942", "l": "5-dehydro-D-gluconate + H(+) + NADH => D-gluconate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450550", "l": "PKCalpha phosphorylates HuR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12513", "l": "D-aspartate + H2O + O2 => H2O2 + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47314", "l": "15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16568", "l": "2-oxoglutarate + L-histidine <=> 3-(imidazol-5-yl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61928", "l": "(R)-miconazole(in) + ATP + H2O = (R)-miconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70466", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + H2O + O2 <=> a 2'-deoxyadenosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32331", "l": "(1S,2S,4R)-endo-fenchol + NAD(+) = (1S,4R)-fenchone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120159", "l": "rRNA pseudouridine synthase activity", "d": ["Catalysis of the reaction: an rRNA uridine = an rRNA pseudouridine. Conversion of uridine in an rRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65568", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56577", "l": "globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine => globoside Gb4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043763", "l": "UTP:glucose-1-phosphate uridylyltransferase regulator activity", "d": ["Binds to and modulates the activity of UTP:glucose-1-phosphate uridylyltransferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029273", "l": "PI3K binds to p-6Y-SYK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043842", "l": "Kdo transferase activity", "d": ["Catalysis of the reactions: (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP, and lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607736", "l": "MALT1 oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799097", "l": "ATM phosphorylates ZNF420 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30982", "l": "A + all-trans-lycopene <=> AH2 + all-trans-3,4-didehydrolycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57101", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => S-methyl-1-thio-D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682388", "l": "Autophagosome maturation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863973", "l": "Fusion of ERC and phagosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.14", "l": "\"methyl-branched lipid omega-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20226", "l": "(E)-caffeate + S-adenosyl-L-methionine => (E)-ferulate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.8", "l": "\"myosin ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420206", "l": "Phosphorylation of SRC-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50509", "l": "acetyl-CoA + N-terminal L-valyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47897", "l": "6-sulfo-D-quinovose + NAD(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52224", "l": "3 AH2 + 3 H(+) + heme b + 3 O2 = 3 A + biliverdin delta + CO + Fe(2+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39725", "l": "a 1,2-diacyl-sn-glycerol(out) => a 1,2-diacyl-sn-glycerol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047902", "l": "formylaspartate deformylase activity", "d": ["Catalysis of the reaction: N-formyl-L-aspartate + H2O = formate + L-aspartate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65119", "l": "2-oxoglutarate + aculene B + O2 <=> aculene A + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1449687", "l": "Corticosteroids bind to CBG in blood (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0070325", "l": "lipoprotein particle receptor binding", "d": ["Binding to a lipoprotein particle receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39265", "l": "(13Z)-docosenoyl-CoA + NADP(+) => (2E,13Z)-docosadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52576", "l": "hexanoyl-CoA + NAD(+) = (2E)-hexenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102245", "l": "lupan-3beta,20-diol synthase activity", "d": ["Catalysis of the reaction: lupan-3beta,20-diol <=> (S)-2,3-epoxysqualene + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71990", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + fusoxypene C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.64", "l": "\"mitochondrial processing peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3785711", "l": "Telomere shortening during replicative exhaustion (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20688", "l": "galactitol + NAD(+) <=> H(+) + keto-D-tagatose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.28", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029456", "l": "RAC1 and CDC42 activate PAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31383", "l": "(S)-2,3-epoxysqualene = lupeol", "d": []}, {"i": "EC:5.4.99.41", "l": "\"lupeol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58013", "l": "cyclic tetraadenylate => 2 5'-hydroxy-diadenylate 2',3'-cylic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39658", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981621", "l": "C3 convertases spontaneously dissociate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29154", "l": "3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out) <=> 3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35764", "l": "8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080077", "l": "trihydroxyferuloyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a trihydroxyferuloyl spermidine molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419428", "l": "S1PR2-5 bind S1P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013158", "l": "CDC42 GDIs block activation of CDC42 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57442", "l": "2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => 2-methylanisole + O2 + reduced [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044015", "l": "histone H2BK12 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 12) = CoA + histone H2B N6-acetyl-L-lysine (position 12)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23756", "l": "D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H(+) + H2O2", "d": []}, {"i": "EC:1.1.3.37", "l": "\"D-arabinono-1,4-lactone oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218820", "l": "Src kinases phosphorylate VAV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102426", "l": "myricetin-3-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: myricetin 3-O-beta-D-glucopyranoside + UDP-alpha-D-glucose <=> myricetin 3-O-gentiobioside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54847", "l": "H(+) + hexan-3-one + NADPH + O2 <=> ethyl butanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23714", "l": "H(+) + NADPH + pregnan-21-al => NADP(+) + pregnan-21-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013438", "l": "RHOD binds effectors at the endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65981", "l": "hnu + previtamin D3 => tachysterol 3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452122", "l": "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198714", "l": "ERK5 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26118", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + epi-cedrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69410", "l": "androst-4-ene-3,11,17-trione + H(+) + NADH => 11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177922", "l": "EGFR dimerization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43608", "l": "agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O = 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate", "d": []}, {"i": "EC:6.3.4.22", "l": "\"tRNA(Ile)(2)-agmatinylcytidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607002", "l": "Activated protein C cleaves factor VIIIa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63012", "l": "(2E,6E)-farnesyl diphosphate + orsellinate = diphosphate + ilicicolinate B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340124", "l": "CSN polymer binds CaPO4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48189", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61146", "l": "H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP => myricetin + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798748", "l": "Exocytosis of secretory granule lumen proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53102", "l": "2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine => 2-hydroxyestrone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16885", "l": "2 bilirubin-glucuronoside = bilirubin IXalpha + bilirubin-bisglucuronoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41239", "l": "N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2 = N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43571", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) <=> 3,6-anhydro-L-galactonate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453183", "l": "p-Y348-SYK dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794444", "l": "ALB binds Cipro (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66303", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose <=> an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047689", "l": "aspartate racemase activity", "d": ["Catalysis of the reaction: L-aspartate = D-aspartate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714580", "l": "SLC6A3 binds DRIs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001591", "l": "dopamine neurotransmitter receptor activity, coupled via Gi/Go", "d": ["Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047028", "l": "6-pyruvoyltetrahydropterin 2'-reductase activity", "d": ["Catalysis of the reaction: NADP+ + 6-lactoyl-5,6,7,8-tetrahydropterin = NADPH + H+ + 6-pyruvoyltetrahydropterin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23196", "l": "3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine = 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine", "d": []}, {"i": "EC:6.3.2.26", "l": "\"N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68664", "l": "17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34014", "l": "5-dehydroepisterol + 2 H2O + NADP(+) <=> ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21675", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine <=> [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782943", "l": "UV-DDB ubiquitinates XPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641206", "l": "RSPOs bind LGRs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912727", "l": "CBL binds VAV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693783", "l": "NAALADases hydrolyse NAAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36121", "l": "O-methyl gibberellin A9 + S-adenosyl-L-homocysteine => gibberellin A9 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110244", "l": "Excision of FapyG by OGG1 glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10485", "l": "H2O + N-feruloylglycine => (E)-ferulate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12353", "l": "L-gulono-1,4-lactone + O2 => H2O2 + L-xylo-hex-3-ulonolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25454", "l": "diphosphate + germacrene A => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004964", "l": "luteinizing hormone receptor activity", "d": ["Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009936", "l": "RNASEL cleaves cellular ssRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59783", "l": "L-histidine + S-adenosyl-L-methionine <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33343", "l": "glycine + O2 = 2-iminoacetate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31334", "l": "ATP + H(+) + molybdopterin <=> adenylyl-molybdopterin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40137", "l": "(9Z)-tetradecenoate + CoA + H(+) => (9Z)-tetradecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.12", "l": "\"xanthan lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26347", "l": "aldehydo-D-galacturonate + H(+) + NADPH => L-galactonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31243", "l": "H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) = (4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12339", "l": "carboxymethoxysuccinate <=> fumarate + glycolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36505", "l": "(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA => (9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49951", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 <=> (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3204303", "l": "MRE11 binds cytosolic DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36804", "l": "2-hydroxy-2,3-dihydrogenistein => genistein + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26428", "l": "ADP + CTP + 2 H(+) + L-glutamate + phosphate => ATP + H2O + L-glutamine + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389026", "l": "Galanin receptors can bind galanin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47712", "l": "trans-3-hydroxy-L-proline = cis-3-hydroxy-D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33822", "l": "3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate <=> 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043852", "l": "monomethylamine methyltransferase activity", "d": ["Catalysis of the reaction: monomethylamine + a monomethylamine corrinoid protein = a methylated monomethylamine corrinoid protein + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9656891", "l": "OPN1SW binds 11cRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433451", "l": "JAK2 binds to p-KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12323", "l": "17-O-acetylnorajmaline + NADP(+) <=> 1,2-dihydrovomilenine + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.7.2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018511", "l": "2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity", "d": ["Catalysis of the reaction: cis-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD+ = 2,3-dihydroxy-p-cumate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68655", "l": "2 L-homocysteine <=> H(+) + hydrogen sulfide + L-homolanthionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17612", "l": "L-seryl-[sulfatase] + S-adenosyl-L-methionine <=> 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14723", "l": "H(+) + O-beta-D-xylosylzeatin + UDP => UDP-alpha-D-xylose + zeatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72076", "l": "ATP + gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine => ADP + H(+) + ophthalmate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72331", "l": "3-hydroxy-4-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3321883", "l": "MSL acetylates histone H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008986", "l": "pyruvate, water dikinase activity", "d": ["Catalysis of the reaction: ATP + H2O + pyruvate = AMP + 3 H+ + phosphate + phosphoenolpyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12967", "l": "1-phospho-alpha-D-galacturonate + ADP + H(+) => ATP + D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944227", "l": "Association of procollagen type XXII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2471670", "l": "Defective RDH12 does not reduce atRAL to atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70089", "l": "hydroxyclavatol methyl ether => methanol + o-quinone methide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45833", "l": "(3R)-3-hydroxydecanoyl-CoA + NAD(+) => 3-oxodecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27539", "l": "ethanol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63718", "l": "losartan-1-N-beta-D-glucuronide + UDP => losartan + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76102", "l": "a dicarboxylate(in) + xanthurenate(out) <=> a dicarboxylate(out) + xanthurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64996", "l": "ATP + H(+) + octanoate = diphosphate + octanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30985", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein] => H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015567", "l": "alkane transmembrane transporter activity", "d": ["Enables the transfer of alkanes from one side of a membrane to the other. Alkanes are saturated aliphatic hydrocarbon compounds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30970", "l": "9,9',15-tri-cis-zeta-carotene <=> 9,9'-di-cis-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-213406", "l": "Disassociation of PLC-gamma1 from LAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696491", "l": "CNTF binds CNTFR complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41929", "l": "(2E)-octadecenoyl-[ACP] + H(+) + NADPH => NADP(+) + octadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31363", "l": "NADP(+) + reduced coenzyme F420-(gamma-L-Glu)(n) = 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.5.1.40", "l": "\"8-hydroxy-5-deazaflavin:NADPH oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701147", "l": "TRPV1 binds TRPV1 blockers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15203", "l": "6-methoxymellein + H(+) + S-adenosyl-L-homocysteine => 6-hydroxymellein + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44007", "l": "3-methyl fatty acid + ATP + CoA <=> a 3-methyl fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120274", "l": "virus coreceptor activity", "d": ["Combining with a virus component, and in cooperation with a nearby primary receptor, initiating a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034943", "l": "trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity", "d": ["Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42582", "l": "AMP + diphosphate + H(+) + L-seryl-tRNA(Sec) => ATP + L-serine + tRNA(Sec)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20199", "l": "[heparan-N-sulfate](n) => [heparosan-N-sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12368", "l": "2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH2", "d": []}, {"i": "EC:1.1.99.4", "l": "\"dehydrogluconate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40459", "l": "(2S)-pristanoyl-CoA + O2 = (2E)-pristenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55565", "l": "4-hydroxytryptamine + ATP => 4-hydoxytryptamine 4-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712081", "l": "ALK fusions bind FRS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180013", "l": "lysophosphatidylserine flippase activity", "d": ["Catalysis of the movement of a lysophosphatidylserine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985153", "l": "OASL binds DDX58 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849900", "l": "SALMs1-3 bind each other in cis interactions (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54694", "l": "(13E)-labda-7,13-dien-15-yl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30148", "l": "FADH2 + NAD(+) => FAD + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72751", "l": "H2O + ochratoxin A = L-phenylalanine + ochratoxin alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080096", "l": "phosphatidate-sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: a phosphatidate + a sterol = a sterol ester + a lysophosphatidate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25689", "l": "H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) <=> L-cysteinyl-tRNA(Cys) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950218", "l": "Expression of Moesin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21693", "l": "CDP-glycerol + H2O => CMP + 2 H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47875", "l": "ganglioside GM1 + H2O <=> ganglioside GA1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71046", "l": "L-alanine(in) + L-phenylalanine(out) <=> L-alanine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102846", "l": "1-18:3-2-16:1-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72620", "l": "2-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201603", "l": "Caspase-mediated cleavage of PKC theta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507875", "l": "Aquaporins passively transport urea into cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47168", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213239", "l": "Formation of MHC II alpha beta heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016085", "l": "myoinhibitory hormone activity", "d": ["The action characteristic of myostimulatory hormone, a peptide hormone that inhibits muscle contraction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67023", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2471621", "l": "Endostatin degradation by cathepsins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48339", "l": "a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2247511", "l": "STAB2:ligand is endocytosed (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54975", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48993", "l": "1,3,7-trimethylurate + H(+) + NADH + O2 => 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68596", "l": "(2E,6E)-farnesyl diphosphate = beta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804266", "l": "CHEK2 phosphorylates TTC5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62652", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA = 6 CO2 + 7 CoA + H2O + naphtopyrone YWA1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29426", "l": "ATP + diphosphate <=> ADP + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59821", "l": "2 ATP => adenosine 3'-diphosphate,5'-triphosphate + AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12597", "l": "acetyl-CoA + phosphinothricin = CoA + H(+) + N-acetylphosphinothricin", "d": []}, {"i": "EC:2.3.1.183", "l": "\"phosphinothricin acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58230", "l": "H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide => L-asparaginyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49378", "l": "12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30020", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + H(+) + lipid A-core", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36678", "l": "octacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(octacosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799326", "l": "Signal-containing nascent peptide translocates to endoplasmic reticulum (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37234", "l": "H2O + L-alaninamide <=> L-alanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16155", "l": "an aldehyde + H2O2 + NH4(+) => an aliphatic amine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10723", "l": "2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955844", "l": "RBKS phosphorylates ribose to R5P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73339", "l": "ATP + beta-alanine + H(+) = beta-alanyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.-", "l": "\"Dipeptidyl-peptidases and tripeptidyl-peptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624798", "l": "LBR binds KPNB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65444", "l": "butanoyl-CoA + hexan-1-ol = CoA + hexyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879293", "l": "formylmycothiol hydrolyzes into mycothiol and formate (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33014", "l": "(+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798372", "l": "ATM phosphorylates DYRK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22243", "l": "H2O + methylenediurea <=> N-(carboxyaminomethyl)urea + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51987", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20945", "l": "S-adenosyl-L-methionine + theobromine => caffeine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23348", "l": "(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) = (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2", "d": []}, {"i": "EC:4.1.1.44", "l": "\"4-carboxymuconolactone decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3244643", "l": "STING binds cyclic GMP-AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1297444", "l": "Binding of cAMP to HCN channels (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34777", "l": "a 3-oxosteroid + CO2 + NADH => a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21310", "l": "cycloartenol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194809", "l": "botD LC cleaves target cell VAMP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33689", "l": "CoA + H(+) + taxol => 3'-N-debenzoyltaxol + benzoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.7", "l": "\"chaperonin ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202714", "l": "CD58 binds CD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44653", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11107", "l": "N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine <=> H(+) + hercynine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67142", "l": "H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein] => L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051380", "l": "norepinephrine binding", "d": ["Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389862", "l": "Conversion of glyoxylate to oxalate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34916", "l": "D-galactose(in) => D-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045436", "l": "lycopene beta cyclase activity", "d": ["Catalysis of the cyclization of beta rings at one or both ends of the lycopene molecule (psi, psi-carotene) to form gamma-carotene or the bicyclic beta-carotene (beta, beta-carotene), respectively."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9641111", "l": "Parkin transfers Ub to misfolded proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676596", "l": "TRAF3 binds BAFFR:BAFF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20935", "l": "L-erythrulose 1-phosphate <=> dihydroxyacetone phosphate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375151", "l": "Interaction of NCAM1 with collagens (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937807", "l": "SRC phosphorylates RUNX3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63065", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + tetraacetate lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74449", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58997", "l": "H2O + indole-3-carbaldehyde + O2 => H(+) + H2O2 + indole-3-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12881", "l": "ADP-alpha-D-glucose + sn-glycerol 3-phosphate = 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.4.1.213", "l": "\"glucosylglycerol-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69166", "l": "2 H(+) + N-(2-carboxyethyl)putrescine + NADH => H2O + N-(4-aminobutyl)-3-aminopropanal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45234", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) => a (2E,4Z)-dienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.74456172809515", "identifiers": [{"i": "GO:0016875", "l": "ligase activity, forming carbon-oxygen bonds", "d": ["Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}, {"i": "EC:6.1.-.-", "l": "\"Forming carbon-oxygen bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47244", "l": "(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.863640214551324", "identifiers": [{"i": "GO:0003905", "l": "alkylbase DNA N-glycosylase activity", "d": ["Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74986", "l": "Elongation of pre-rRNA transcript (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56259", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74824", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46792", "l": "an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682709", "l": "LGI4 binds ADAM22,23,11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66573", "l": "2-naphthol + 3'-phosphoadenylyl sulfate => 2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693148", "l": "BCKDK phosphorylates BCKDH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41613", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O => D-ribose 2,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56532", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190245", "l": "FGFR1b binds to FGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2032775", "l": "YAP1 binds TEAD1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15303", "l": "aldehydo-D-apiose + H(+) + NADH => D-apiitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72672", "l": "The 60S subunit joins the translation initiation complex  (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36220", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75180", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (R)-axinyssene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9754964", "l": "ADA deamidates RBV (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45600", "l": "D-galactaro-1,4-lactone = 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605724", "l": "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75267", "l": "D-arabinose + NADP(+) = D-arabinono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399928", "l": "Recruitment of Rnd1 to Plexin A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043719", "l": "2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity", "d": ["Catalysis of the reaction: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + O2 + H+ = 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322429", "l": "XIAP monoubiquinates TLE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44204", "l": "2-hydroxyhexadecanoate + ATP + CoA = 2-hydroxyhexadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75238", "l": "L-fucono-1,5-lactone <=> L-fucono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165043", "l": "Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44719", "l": "A + all-trans-4,4'-diapolycopen-4-al + H2O <=> AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114354", "l": "SMAC binds XIAP:Caspase-7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31045", "l": "2 H(+) + methylmalonate + NADH => (S)-methylmalonate semialdehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19478", "l": "4-hydroxybenzoate + H(+) + NADPH + O2 => 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682011", "l": "LC3 binds ATG7 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58348", "l": "2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 = 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372564", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15767", "l": "adenosylcob(III)inamide phosphate + GDP + H(+) => adenosylcob(III)inamide + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11558", "l": "3-dehydrocarnitine + H(+) + NADH => (S)-carnitine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50860", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-936963", "l": "IRAK2 induces TRAF6 oligomerization (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43402", "l": "H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP => N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156910", "l": "Formation of eEF1B complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58947", "l": "6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH <=> 7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51643", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44305", "l": "a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA => a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694499", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30540", "l": "(R)-carnitinyl-CoA => (S)-carnitinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679775", "l": "COMT binds COMT Inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617815", "l": "BBSome binds RAB3IP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27518", "l": "H2O + sphing-4-enine 1-phosphate = phosphate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56377", "l": "3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 => 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24537", "l": "L-tryptophan + O2 => N-formyl-L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984733", "l": "Kinesin-3 is a dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45695", "l": "N-(octanoyl)-sphing-4-enine-1-phosphate(in) <=> N-(octanoyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55570", "l": "2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine => 4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58757", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48016", "l": "4-methyl-5-nitrocatechol + NADH + O2 = 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22246", "l": "H(+) + kaempferol 3-O-beta-D-xyloside + UDP => kaempferol + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54740", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.112", "l": "\"indanol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602473", "l": "Autocatalytic activation of MMP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1449574", "l": "SLC2A4 (GLUT4) vesicle fuses with the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950183", "l": "IL12B binds IL23A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40466", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211391", "l": "Anthrax lef cleaves target cell MAP2K4 (MEK4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36885", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19622", "l": "a nucleoside 2',3'-cyclic phosphate + H2O => a nucleoside 3'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296233", "l": "T2Rs bind bitter-tasting compounds (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41776", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0) = CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57015", "l": "a menaquinone + H2O + sulfite <=> a menaquinol + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692749", "l": "CDC14A,B bind MAPK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42399", "l": "cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine <=> 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1370505", "l": "PRLR is phosphorylated at Ser-349 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48563", "l": "H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate <=> D-ribose 5-phosphate + N(6)-dimethylallyladenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75733", "l": "10-oxo-(12Z)-octadecenoate + H(+) + NADH => (10S)-hydroxy-(12Z)-octadecenoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052637", "l": "delta 3-trans-hexadecenoic acid phosphatidylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-3-16:0-phosphatidylglycerol = 1-18:3-3-trans-16:1-phosphatidylglycerol + 2 H+. This reaction is the formation of a trans double bond between carbon 3 and carbon 4 (counting from the carboxyl end) of palmitic acid, which is specifically esterified to the sn-2 glyceryl carbon of phosphatidylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19286", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol => a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944219", "l": "Association of procollagen type XVI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187575", "l": "Ubiquitination of phospho-p27/p21 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27814", "l": "acetate(in) + Na(+)(in) = acetate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2520883", "l": "Phosphorylated condensin I promotes condensation of prometaphase chromosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74394", "l": "methylamine(out) <=> methylamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66658", "l": "Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in) => Cu(2+)(out) + L-ascorbate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9021357", "l": "PRKCI phosphorylates ELF3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218804", "l": "p38 MAPK activation by VEGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444527", "l": "FPR is a receptor for formyl peptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451900", "l": "IL2RB binds JAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202203", "l": "Recruitment of PI3K to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61995", "l": "N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39580", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA => (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23001", "l": "(R)-pantoate + NAD(+) => (R)-4-dehydropantoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33752", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2396337", "l": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33474", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42512", "l": "5-acetamidopentanoate + H2O = 5-aminopentanoate + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44333", "l": "ATP + L-alanine + L-anticapsin => ADP + bacilysin + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53620", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (-)-spiroviolene + diphosphate", "d": []}, {"i": "EC:4.2.3.158", "l": "\"(-)-spiroviolene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14470", "l": "2-aminomuconate 6-semialdehyde + H2O + NAD(+) => (2Z,4E)-2-aminomuconate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873919", "l": "Phosphorylation of JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53451", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51468", "l": "(R)-lactate + a quinone = a quinol + pyruvate", "d": []}, {"i": "EC:1.1.5.12", "l": "\"D-lactate dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391168", "l": "SIRP gamma binds CD47 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68557", "l": "NAD(+) + UDP-N-acetyl-alpha-D-quinovosamine => H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53890", "l": "alpha,alpha-trehalose 6-phosphate + H(+) + TDP => D-glucose 6-phosphate + TDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102313", "l": "1,8-cineole synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate(3-) + H2O <=> 1,8-cineole + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140769", "l": "factor VII -> factor VIIa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956365", "l": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12261", "l": "ATP + NADH => ADP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52246", "l": "2 H2O + 4 Mn(3+) => 4 H(+) + 4 Mn(2+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39030", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36623", "l": "3-phenylpyruvate + S-adenosyl-L-methionine = (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.281", "l": "\"phenylpyruvate C(3)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2468040", "l": "Cohesin binds PDS5 and WAPAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34483", "l": "4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA = 4-hydroxybenzalacetone + 2 CO2 + 2 CoA", "d": []}, {"i": "EC:2.3.1.212", "l": "\"benzalacetone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49992", "l": "H(+) + NADH + O2 + propane = H2O + NAD(+) + propan-2-ol", "d": []}, {"i": "EC:1.14.13.227", "l": "\"propane 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942302", "l": "MMP13 cleaves OPTC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420128", "l": "SRC-1 phosphorylates SHB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19690", "l": "L-rhamnulose 1-phosphate => (S)-lactaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40898", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814094", "l": "ARL1:GTP binds ARFIP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35227", "l": "H(+)(out) + rifampicin(in) = H(+)(in) + rifampicin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.16", "l": "\"ribulokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68552", "l": "NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine = H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630044", "l": "Defective NTHL1 truncation mutants do not bind formamidopyrimidine (FapyA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53026", "l": "5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+) => a plastoquinone + H2O + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70295", "l": "2-oxoglutarate + 3-sulfino-L-alanine = 3-sulfinopyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51419", "l": "a (2S,3R)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156699", "l": "Inactivation of Wee1 kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39733", "l": "3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66140", "l": "acetyl-CoA + octopamine = CoA + H(+) + N-acetyloctopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10736", "l": "a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27622", "l": "geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate", "d": []}, {"i": "EC:2.5.1.89", "l": "\"tritrans,polycis-undecaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0046623", "l": "sphingolipid floppase activity", "d": ["Catalysis of the movement of a sphingolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55619", "l": "a carotenoid psi-end group <=> a carotenoid epsilon-end group", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65872", "l": "1,17beta-dihydroxyandrostan-3-one + A = 17beta-hydroxyandrostan-1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675198", "l": "Activated MAPKs phosphorylate BRAF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74885", "l": "GUCYs converts GTP to cGMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34419", "l": "(+)-lariciresinol + NADP(+) = (+)-pinoresinol + H(+) + NADPH", "d": []}, {"i": "EC:1.23.1.1", "l": "\"(+)-pinoresinol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.2.10", "l": "\"lanthanide-dependent methanol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624120", "l": "CEBPA binds CDK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.10", "l": "\"carboxypeptidase E\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203567", "l": "palmitoylation of eNOS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50614", "l": "(2E)-decenal + H(+) + NADPH => decanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876484", "l": "NPC2 transfers CHOL to NPC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182990", "l": "Sprouty sequesters CBL away from active EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49974", "l": "16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.440173563602954", "identifiers": [{"i": "GO:0019787", "l": "ubiquitin-like protein transferase activity", "d": ["Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74937", "l": "(3R)-3-isocyanylbutanoate + 3 CO2 + 2 H2O + 2 succinate => (3R)-3-[(carboxymethyl)amino]butanoate + 2 2-oxoglutarate + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015576", "l": "sorbitol transmembrane transporter activity", "d": ["Enables the transfer of sorbitol from one side of a membrane to the other. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44982", "l": "CoA + O-butanoyl-(R)-carnitine => (R)-carnitine + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12972", "l": "a sn-glycero-3-phosphodiester + H2O <=> an alcohol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20043", "l": "2 H(+) + malonate + NADPH => 3-oxopropanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048032", "l": "galacturonate binding", "d": ["Binding to a galacturonate. Galacturonate is the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687121", "l": "nsp8 binds MAP1LC3B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468040", "l": "Cohesin binds PDS5 and WAPAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139919", "l": "Translocation of BIM to mitochondria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37650", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0160008", "l": "protein decrotonylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein]."]}, {"i": "RHEA:69172", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102586", "l": "cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + 1-O-sinapoyl-beta-D-glucose <=> cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6'-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67529", "l": "(6Z)-octenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(6Z-octenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45318", "l": "11beta-prostaglandin F2 + NADP(+) => H(+) + NADPH + prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646390", "l": "Misfolded proteins:HDAC6:Dynein motor binds microtubule (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734475", "l": "PPARA binds fibrates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1671687", "l": "PRLR activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22334", "l": "2-methylmaleate + H2O => (3R)-citramalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9615249", "l": "ARBs bind AGRT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29315", "l": "alpha-D-galactose 1-phosphate + H2O = D-galactose + phosphate", "d": []}, {"i": "EC:3.1.3.94", "l": "\"D-galactose 1-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672817", "l": "Active MTORC1 binds the ULK1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672961", "l": "PP2A dephosphorylates inactive RAFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71817", "l": "3,3',5'-triiodo-L-thyronine(in) => 3,3',5'-triiodo-L-thyronine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950398", "l": "CANX dissociates from IL27:EBI3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22306", "l": "5-dehydro-D-fructose + a ubiquinol => a ubiquinone + keto-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26086", "l": "(4S)-limonene + H(+) + NADPH + O2 => H2O + limonene 1,2-epoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63874", "l": "3(1)-hydroxy-L-isoleucine + CO2 + succinate => 2-oxoglutarate + L-isoleucine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62839", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51051", "l": "5alpha-androstan-3,17-dione + A <=> AH2 + androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31256", "l": "(2S)-2-acetolactate => 3-hydroxy-3-methyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15087", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49215", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31685", "l": "(-)-solanapyrone A => prosolanapyrone III", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0070259", "l": "tyrosyl-DNA phosphodiesterase activity", "d": ["Catalysis of the hydrolysis of phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033858", "l": "N-acetylgalactosamine kinase activity", "d": ["Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099184", "l": "structural constituent of postsynaptic intermediate filament cytoskeleton", "d": ["The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41179", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41995", "l": "17beta-hydroxy-5alpha-androstan-3-one + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36288", "l": "H(+) + NADPH + O2 + theobromine => 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42010", "l": "5alpha-pregnane-3,20-dione + H(+) + NADH => 5alpha-pregnan-20beta-ol-3-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249378", "l": "STING recruits TBK1 and STAT6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63794", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62535", "l": "digitoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) <=> dihydrodigitoxin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102930", "l": "4-hydroxybenzoate geranyltransferase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + 4-hydroxybenzoic acid = 3-geranyl-4-hydroxybenzoate + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75164", "l": "NAD(+) + UTP => H(+) + NADP(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189457", "l": "Mitochondrial intermembrane PRIN9 translocates to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32683", "l": "5-hydroxymethylfurfural + 2 H2O + 3 O2 = 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2", "d": []}, {"i": "EC:1.1.3.47", "l": "\"5-(hydroxymethyl)furfural oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110218", "l": "Cleavage of uracil by TDG glycosylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16588", "l": "[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50565", "l": "acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250498", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16182", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine => 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38852", "l": "H(+) + tetracenomycin F2 => H2O + tetracenomycin F1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16754", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 => 3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420265", "l": "AMY1-3 bind IAPP(34-70) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37845", "l": "1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25058", "l": "(E)-cinnamate + H(+) + NADH + O2 = (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33909", "l": "4-aminobutanoate + formaldehyde + H2O2 => 4-(methylamino)butanoate + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614605", "l": "Persulfide sulfur is dioxygenated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75025", "l": "9-(9Z,12Z-octadecadienoyloxy)-octadecanoate + di-(9Z,12Z)-octadecadienoylglycerol => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40987", "l": "EDTA + 2 FMNH2 + 2 O2 = ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O", "d": []}, {"i": "EC:1.14.14.33", "l": "\"ethylenediaminetetraacetate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218806", "l": "FYN autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66711", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112514", "l": "JAK activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29425", "l": "ADP + H(+) + triphosphate => ATP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72621", "l": "Ribosomal scanning  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70622", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195734", "l": "Neuraminidase (NA) synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693540", "l": "MRN activates ATM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25370", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) <=> H(+) + momilactone A + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938022", "l": "RUNX1:CBFB binds the NR4A3 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985943", "l": "p-Y701-STAT1 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25379", "l": "2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43032", "l": "3-chloro-D-alanine = 2-aminoprop-2-enoate + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952371", "l": "MDM2 binds RUNX3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21748", "l": "(S)-lactaldehyde + NADP(+) = H(+) + methylglyoxal + NADPH", "d": []}, {"i": "EC:1.1.1.283", "l": "\"methylglyoxal reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114558", "l": "Thrombin-activated PARs activate Gq (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23548", "l": "guanosine(966) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.171", "l": "\"16S rRNA (guanine(966)-N(2))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36144", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADPH => hexadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43524", "l": "L-allo-threonine + NADP(+) = aminoacetone + CO2 + NADPH", "d": []}, {"i": "EC:1.1.1.381", "l": "\"3-hydroxy acid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199579", "l": "KIR2DL4 interacting with HLA-G (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34614", "l": "N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose <=> H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768142", "l": "Dimerized phospho-IRF3, IRF7 is transported to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64706", "l": "benzophenone + H(+) + NADH => diphenylmethanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.41", "l": "\"(E)-2-methylbutanal oxime monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047300", "l": "pyridoxamine-pyruvate transaminase activity", "d": ["Catalysis of the reaction: pyridoxamine + pyruvate = L-alanine + pyridoxal."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052664", "l": "nitroalkane oxidase activity", "d": ["Catalysis of the reaction: nitroalkane + H2O + O2 = an aldehyde or ketone + nitrite + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46940", "l": "AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] = ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102445", "l": "3-methylquercetin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5-trihydroxy-3-methoxyflavon-7-olate + S-adenosyl-L-methionine <=> 3,3'-dimethylquercetin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141423", "l": "Binding of the MCC complex to the APC/C complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109813", "l": "GRB2-1 binds SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247836", "l": "Retromer recycles WLS to the Golgi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52949", "l": "deoxycholate + UDP-alpha-D-glucuronate => deoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610735", "l": "NUMB binds ITCH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444647", "l": "C3a receptor binds anaphylatoxin C3a (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69869", "l": "a 5-methyluridine in RNA + H(+) + S-adenosyl-L-homocysteine => a uridine in RNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67279", "l": "H2O + hexanal + NAD(+) <=> 2 H(+) + hexanoate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18226", "l": "[N-(6-aminohexanoyl)](n) + H2O => 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350651", "l": "Caspase-mediated cleavage of MASK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39436", "l": "(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008721", "l": "D-serine ammonia-lyase activity", "d": ["Catalysis of the reaction: D-serine = pyruvate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22264", "l": "3,5,6-trichloropyridin-2-ol + FADH2 + O2 = 3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-984671", "l": "Chromokinesins form dimers (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362522", "l": "ALDHs oxidise atRAL to atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29980", "l": "2'-deoxyadenosine(in) + H(+)(in) => 2'-deoxyadenosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247837", "l": "WNT ligands traffic to the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46451", "l": "2 L-tyrosyl-tRNA(Tyr) <=> cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13741", "l": "3-phenylpyruvate + L-tryptophan = indole-3-pyruvate + L-phenylalanine", "d": []}, {"i": "EC:2.6.1.28", "l": "\"tryptophan--phenylpyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20168", "l": "H2O + N(5)-acyl-L-ornithine ester <=> an alcohol + H(+) + N(5)-acyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008910", "l": "kanamycin kinase activity", "d": ["Catalysis of the reaction: ATP + kanamycin = ADP + 2 H+ + kanamycin 3'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169398", "l": "ISGylation of host protein filamin B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0005222", "l": "intracellular cAMP-activated cation channel activity", "d": ["Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71544", "l": "5-hydroxymethyl-dUMP in DNA + ATP => 5-phosphomethyl-dUMP in DNA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22598", "l": "acetate + deacetylcephalosporin C + H(+) => cephalosporin C + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606839", "l": "Steryl sulfatase hydrolyses sulfate from steroid sulfates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430308", "l": "PARVB interacts with Alpha-actinin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33767", "l": "a 3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.98.-", "l": "\"With other known acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635843", "l": "GLI translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41686", "l": "1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+) => 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23572", "l": "3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + phlorisovalerophenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41839", "l": "H(+) + hexanoyl-[ACP] + malonyl-[ACP] <=> 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75850", "l": "Addition of the third nucleotide on the nascent transcript (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.8", "l": "\"protein-disulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64449", "l": "L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54322", "l": "a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57530", "l": "a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + AMP + 2 diphosphate + H(+) => a 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26510", "l": "H2O + L-prolinamide = L-proline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047953", "l": "glycerol 2-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: glycerol + NADP+ = glycerone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60887", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O <=> (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390929", "l": "HTR1 and 5A receptors can bind serotonin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54244", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62105", "l": "(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67822", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0047225", "l": "acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25097", "l": "ATP + dCMP <=> ADP + dCDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63192", "l": "[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 = glycine betaine + 2 H(+) + phosphate", "d": []}, {"i": "EC:1.13.11.90", "l": "\"[1-hydroxy-2-(trimethylamino)ethyl]phosphonate dioxygenase (glycine-betaine-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19681", "l": "ATP + biotin + CoA = AMP + biotinyl-CoA + diphosphate", "d": []}, {"i": "EC:6.2.1.11", "l": "\"biotin--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32388", "l": "dihydrocarveol + NAD(+) => dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16810", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate => pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445700", "l": "Myosin Binds ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140968", "l": "polyspecific organic cation:proton antiporter activity", "d": ["Enables the transfer of various organic cations in exchange for a proton, according to the reaction: H+(out) + organic cation(in) = H+(in) + organic cation(out). The transported substrates are usually toxic molecules, drugs and xenobiotics."]}, {"i": "TCDB:2.A.66.1.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57767", "l": "2,6-dinitrotoluene + NADH + O2 <=> 3-methyl-4-nitrocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61266", "l": "H2O2 + NH4(+) + pyruvate => H2O + L-alanine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11795", "l": "H(+) + NADH + O2 + propene <=> 1,2-epoxypropane + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.21", "l": "\"catalase peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.7", "l": "\"enzyme-thiol transhydrogenase (glutathione-disulfide)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004322", "l": "ferroxidase activity", "d": ["Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47262", "l": "16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749215", "l": "MCM8 binds CDC6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47511", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isolithocholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16858", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine => an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46749", "l": "carboxyphosphate + NH4(+) => carbamate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.13", "l": "\"glutathione gamma-glutamate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855217", "l": "I(1,4,5)P3 transports from the ER lumen to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0046857", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP."]}, {"i": "EC:1.7.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39113", "l": "4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH => 4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16290", "l": "(1R,2S)-ephedrine + NAD(+) => (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53301", "l": "D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O => H(+) + N-carbamoyl-D-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53251", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-oxocholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29653", "l": "agmatine(out) + L-arginine(in) => agmatine(in) + L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.40", "l": "\"malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68455", "l": "all-trans-10'-apo-beta-carotenal + O2 <=> 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27973", "l": "D-maltotriose + H2O <=> alpha-D-glucose + D-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13500", "l": "5-dehydro-2-deoxy-D-gluconate + ATP <=> 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49537", "l": "2-amino-2-deoxy-D-gluconate => (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950778", "l": "p-Y693-STAT4 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60793", "l": "3 2-oxoglutarate + gibberellin A53 + 3 O2 => 3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28570", "l": "ATP + L-serine = diphosphate + L-seryl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42716", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate = (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate", "d": []}, {"i": "EC:2.9.1.3", "l": "\"tRNA 2-selenouridine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5631941", "l": "SESN1,2,3 bind AMPK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62860", "l": "acetyl-CoA + 7 H(+) + 7 malonyl-CoA = 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28054", "l": "2-oxobutanoate + CoA = formate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047405", "l": "pyrimidine-5'-nucleotide nucleosidase activity", "d": ["Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45081", "l": "3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine => ADP + dapdiamide E + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12753", "l": "glycerol + NADP(+) = dihydroxyacetone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.156", "l": "\"glycerol 2-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016153", "l": "urocanate hydratase activity", "d": ["Catalysis of the reaction: 4-imidazolone-5-propanoate + H+ = trans-urocanate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848930", "l": "PTK6 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50022", "l": "adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+) => decanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27330", "l": "H(+) + NADH + O2 + urate => 5-hydroxyisourate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30317", "l": "7-methylxanthine + formaldehyde + H2O + NAD(+) => 1,7-dimethylxanthine + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102685", "l": "UDP-glucose:trans-zeatin 7-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + trans-zeatin <=> H+ + trans-zeatin-7-N-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696958", "l": "USP44 deubiquitinates CDC20 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28787", "l": "4-hydroxy-L-threonine + ATP = 4-(phosphooxy)-L-threonine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60250", "l": "AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] => A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71728", "l": "citrate(out) + fumarate(in) => citrate(in) + fumarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072549", "l": "monocoumaroyl dicaffeoyl spermidine meta-hydroxylase activity", "d": ["Catalysis of the reaction: monocoumaroyl dicaffeoyl spermidine + NADPH + O2 = tricaffeoyl spermidine + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14187", "l": "2-phenylacetaldehyde + CO2 => 3-phenylpyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53838", "l": "a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20036", "l": "isopenicillin N <=> penicillin N", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13128", "l": "CoA + glutathione disulfide <=> CoA-glutathione + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033943", "l": "galactan 1,3-beta-galactosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in (1->3)-beta-D-galactopyranans."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052676", "l": "3-methylbutanol:NAD oxidoreductase activity", "d": ["Catalysis of the reaction: 3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+. 3-methylbutanal is also known as isovaleraldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21578", "l": "2-methylcholine + CO2 => carnitine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3371422", "l": "ATP hydrolysis by HSP70 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5580269", "l": "Defective CYP11A1 does not cleave 20a,22b-DHCHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382057", "l": "Release of novel PDGFs as latent factors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34875", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) = 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050659", "l": "N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity", "d": ["Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652277", "l": "ERBB2 binds trastuzumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156930", "l": "GTP-binding activates eEF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.938386572175233", "identifiers": [{"i": "GO:0008395", "l": "steroid hydroxylase activity", "d": ["Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110307", "l": "REV1 binds AP-dsDNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31080", "l": "3-hydroxyisovaleryl-CoA => 3-methyl-(2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102768", "l": "anthocyanidin synthase activity", "d": ["Catalysis of the reaction: flavan-3,3',4,4',5,5',7-heptol + O2 + 2-oxoglutarate = H+ + delphinidin + 2 H2O + carbon dioxide + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72225", "l": "4-hydroxy-L-proline + chloride(in) + 2 Na(+)(in) => 4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39322", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62285", "l": "2 ATP + L-proline + L-tryptophan + NADPH => (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23342", "l": "D-arabinose + pyruvate => 3-deoxy-alpha-D-manno-oct-2-ulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13164", "l": "L-threonine + NAD(+) <=> (2S)-2-amino-3-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50868", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71744", "l": "2-oxoglutarate(out) + hexanedioate(in) => 2-oxoglutarate(in) + hexanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44014", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + holo-[ACP] => (9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42971", "l": "cytidine(56) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034896", "l": "3-formiminopyruvate hydrolase activity", "d": ["Catalysis of the reaction: 3-formiminopyruvate + H2O = 3-formylpyruvate + HN3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52076", "l": "13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70085", "l": "H2O + o-quinone methide => hydroxyclavatol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71084", "l": "estrone 3-sulfate(out) + 2 Na(+)(out) => estrone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22448", "l": "ATP + pseudouridine = ADP + H(+) + psi-UMP", "d": []}, {"i": "EC:2.7.1.83", "l": "\"pseudouridine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088338", "l": "Defective GNE does not hydrolyse UDP-GlcNAc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10120", "l": "adenosine in double-stranded RNA + H(+) + H2O = inosine in double-stranded RNA + NH4(+)", "d": []}, {"i": "EC:3.5.4.37", "l": "\"double-stranded RNA adenine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18885", "l": "GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.271", "l": "\"GDP-L-fucose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210294", "l": "Interaction of PECAM-1 and SHP-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49044", "l": "H(+) + NADH + O2 + protoasukamycin = 4-hydroxyprotoasukamycin + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.215", "l": "\"protoasukamycin 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33994", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-copaene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675656", "l": "EDA:EDAR binds EDARADD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61141", "l": "(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + myricetin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42749", "l": "cytidine(967) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47965", "l": "H2O + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75496", "l": "n H(+)(out) + pregnenolone sulfate(out) => n H(+)(in) + pregnenolone sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21363", "l": "ATP + beta-nicotinamide D-ribonucleotide + H(+) <=> diphosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60006", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate => (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68893", "l": "3-methoxybenzoate + ATP + H(+) + NADPH => 3-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810937", "l": "Lamellar bodies bind the early cornified envelope (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34211", "l": "ecgonine methyl ester + NADP(+) = ecgonone methyl ester + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.334", "l": "\"methylecgonone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9659820", "l": "RB1 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11845", "l": "acetyl-CoA + formate => CoA + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11401", "l": "GDP-6-deoxy-alpha-D-altrose + sordaricin => 4'-O-demethylsordarin + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52120", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31898", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-humulene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42120", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45305", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53832", "l": "2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032030", "l": "myosin I light chain binding", "d": ["Binding to a light chain of a myosin I complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25883", "l": "2 L-dopa + O2 <=> 2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75862", "l": "Fall Back to Closed Pre-initiation Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672951", "l": "Inactive RAFs bind YWHAB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34396", "l": "L-phenylalanine => L-beta-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004968", "l": "gonadotropin-releasing hormone receptor activity", "d": ["Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18040", "l": "agmatine + H2O <=> N-carbamoylputrescine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18649", "l": "D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49169", "l": "8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9612509", "l": "SGK phosphorylates SRF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48007", "l": "1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 <=> 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35062", "l": "chloramphenicol(in) + H(+)(out) <=> chloramphenicol(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3321883", "l": "MSL acetylates histone H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823989", "l": "Expression of FOXA2 in definitive endoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798611", "l": "TP53 stimulates and ZNF420 inhibits TP53AIP1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42231", "l": "17beta-estradiol + A <=> AH2 + estrone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68280", "l": "L-seryl-[protein] + pentanoyl-CoA = CoA + O-pentanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62703", "l": "H2O + naphtopyrone YWA1 <=> acetoacetate + H(+) + naphthalene-1,3,6,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848864", "l": "PTK6 binds ARAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57826", "l": "2-deoxy-D-ribose 5-phosphate + adenine => dAMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509831", "l": "ITPA hydrolyses XTP to XMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25410", "l": "ADP + alpha,alpha-trehalose + H(+) => ADP-alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20609", "l": "2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate", "d": []}, {"i": "EC:4.1.2.28", "l": "\"2-dehydro-3-deoxy-D-pentonate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65504", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O = 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine", "d": []}, {"i": "EC:3.4.14.14", "l": "\"[mycofactocin precursor peptide] peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0052636", "l": "arabinosyltransferase activity", "d": ["Catalysis of the transfer of an arabinosyl group from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38277", "l": "acetyl-CoA + pyruvate => (3R)-citramalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204798", "l": "Interaction of Tie2 and p85 of PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.182", "l": "\"taxoid 7beta-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69360", "l": "bromide + H(+) + H2O2 + L-tyrosyl-[protein] = 3-bromo-L-tyrosyl-[protein] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.-", "l": "\"Phosphotransferases with regeneration of donors, apparently catalyzing intramolecular transfers\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48425", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O => (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54887", "l": "L-arginyl-[protein] + NADP(+) <=> H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36438", "l": "a 1,2-diacyl-sn-glycero-3-phosphate(in) <=> a 1,2-diacyl-sn-glycero-3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.191", "l": "\"ginsenosidase type III\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46868", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) = a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623643", "l": "RDH13 reduces atRAL to atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195275", "l": "Phosphorylation of APC component of the destruction complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51953", "l": "(E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66445", "l": "hexan-3-one + NADP(+) => (E)-4-hexen-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951727", "l": "cAMP binds PKA tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004412", "l": "homoserine dehydrogenase activity", "d": ["Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57679", "l": "4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710263", "l": "GZMB cleaves GSDME (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202510", "l": "Activation of TAK1-TAB2 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954082", "l": "E2F6 binds the PRC1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052767", "l": "mannosyl-oligosaccharide 1,6-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of the alpha-(1->6) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50539", "l": "prostaglandin E2 <=> H2O + prostaglandin A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74821", "l": "glutathione(out) => glutathione(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42570", "l": "3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) => 2,3-dihydroxy-p-cumate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16517", "l": "(R)-1-aminopropan-2-ol + NAD(+) = aminoacetone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.75", "l": "\"(R)-aminopropanol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004631", "l": "phosphomevalonate kinase activity", "d": ["Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052789", "l": "mannan 1,3-beta-mannosidase activity", "d": ["Catalysis of the hydrolysis of (1->3)-beta-D-mannosidic linkages in mannans, releasing mannose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694334", "l": "mRNA1 is translated to pp1a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944706", "l": "miR-21 nonendonucleolytic RISC binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950766", "l": "IL27RA dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52862", "l": "a short-chain fatty acyl-CoA + AMP + diphosphate => a short-chain fatty acid + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51214", "l": "12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH => (5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5225649", "l": "RBBP7 binds histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62524", "l": "cytidine(839) in 12S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22901", "l": "(R)-acetoin + NAD(+) => diacetyl + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16732", "l": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) <=> catechol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168947", "l": "Ligand binds to TLR10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56125", "l": "A + all-trans-lycopene + dimethylallyl diphosphate + H2O => AH2 + diphosphate + nonaflavuxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40234", "l": "(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59657", "l": "D-cellotriose + O2 => D-cellotriono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853908", "l": "VENTX stimulates CSF1R (M-CSF-R) expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9703895", "l": "CASR binds CASR agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750942", "l": "USP14 deubiquitinates NLRC5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761849", "l": "AcK-NFE2L2-dependent P6GD gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871260", "l": "YAP1 binds TEAD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70899", "l": "histidine => urocanate + NH4+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65557", "l": "globoside GalGb4Cer + H2O => an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14686", "l": "A + a primary alcohol => AH2 + an aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73757", "l": "Binding of RRN3 to RNA Polymerase I (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417829", "l": "P2RY12 binds ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15562", "l": "S-adenosyl-L-methionine + sterigmatocystin => 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64952", "l": "dCDP + H2O = dCMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48402", "l": "CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] => 2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57192", "l": "H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] = glycolate + H(+) + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645481", "l": "TIFA oligomerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199839", "l": "AKT can phosphorylate RSK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69316", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate = allyl thiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852317", "l": "PLK1 phosphorylates GTSE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052797", "l": "4-O-methyl-glucuronoyl methylesterase activity", "d": ["Catalysis of the reaction: [X]-4-O-methyl-D-glucuronic acid + H2O = [X]-OH + methyl-D-glucuronic acid. This reaction is the hydrolysis of the ester linkage between 4-O-methyl-D-glucuronic acid (MeGlcA) and an alcohol (-OH) group attached to a molecule, denoted here as [X]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.70", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35008", "l": "D-fucose(in) => D-fucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655824", "l": "Expression of Farnesyl Diphosphate Synthase (FDPS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014320", "l": "SARM binds viral dsRNA:TLR3:TICAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-381091", "l": "IRE1 dimer autophosphorylates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61441", "l": "acetyl-CoA + S-(2-succino)-L-cysteine => CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21202", "l": "(S)-2-amino-6-oxohexanoate + L-glutamate => 2-oxoglutarate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27756", "l": "(R)-lactate + H(+) => H2O + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0086089", "l": "voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29567", "l": "2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647746", "l": "EML4 trimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17538", "l": "(R)-carnitinamide + H2O => (R)-carnitine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14581", "l": "H(+) + 2 monodehydro-L-ascorbate radical + NADH = 2 L-ascorbate + NAD(+)", "d": []}, {"i": "EC:1.6.5.4", "l": "\"monodehydroascorbate reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420206", "l": "Phosphorylation of SRC-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39444", "l": "(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH => (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54531", "l": "aldehydo-D-ribose 5-phosphate <=> D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71314", "l": "chloride(out) + L-alanine(out) + 2 Na(+)(out) <=> chloride(in) + L-alanine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48295", "l": "ganglioside GM1 + GDP-beta-L-fucose <=> ganglioside Fuc-GM1 + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796626", "l": "MIB2 ubiquitinates CFLAR  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15912", "l": "2-oxoglutarate + O2 + taurine <=> aminoacetaldehyde + CO2 + H(+) + succinate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39806", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) <=> (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380780", "l": "Activation of Src (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429101", "l": "HMIT co-transports myo-inositol with a proton (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682967", "l": "WHSC1 binds DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55785", "l": "all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate => all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685607", "l": "Sialic acid binds SIGLEC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014433", "l": "RHOG GEFs activate RHOG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392513", "l": "Rap1 signal termination by Rap1GAPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59919", "l": "(2E)-octenal + H2O + NADP(+) <=> (2E)-octenoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605724", "l": "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782820", "l": "USP17 deubiquitinates SUDS3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32381", "l": "(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH => (1R,2R,4S)-limonene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35744", "l": "H(+) + NADPH + O2 + versicolorin B => 2 H2O + NADP(+) + versicolorin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70912", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate => (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70528", "l": "H(+) + N-acyl-3-oxosphinganine + NADH => an N-acylsphinganine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73416", "l": "(-)-cyclopenine => H(+) + methyl isocyanate + viridicatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981073", "l": "Expression of Interleukin-10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103105", "l": "2-oxo-6-methylthiohexanoate aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + a standard alpha amino acid <=> dihomomethionine + a 2-oxo carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111970", "l": "PKC phosphorylates GRK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698927", "l": "Assembly of the HCMV Genome DNA Replication Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58839", "l": "24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65182", "l": "A + H2O + preaustinoid A => AH2 + O2 + protoaustinoid B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22786", "l": "H(+) + phosphoenolpyruvate + sulfite => (2R)-O-phospho-3-sulfolactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013006", "l": "RHOA:GTP translocates to the ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853496", "l": "SCF:FBXL7 binds AURKA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45018", "l": "L-selenomethionine + tetrahydropteroyltri-L-glutamate => 5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28161", "l": "alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903879", "l": "11beta-hydroxyprogesterone binding", "d": ["Binding to 11beta-hydroxyprogesterone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863463", "l": "STON2 binds SYT proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090562", "l": "protein-N(PI)-phosphohistidine-N,N'-diacetylchitobiose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N,N'-diacetylchitobiose(out) = protein histidine + N,N'-diacetylchitobiose phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39936", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46323", "l": "3beta-hydroxy-chol-5-ene-24-oyl-CoA + A <=> 3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73596", "l": "dCMP + H2O => dUMP + NH4+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53029", "l": "lithocholate + UDP-alpha-D-glucuronate => H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37697", "l": "1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60116", "l": "2-oxoglutarate + methylphosphonate + O2 = CO2 + hydroxymethylphosphonate + succinate", "d": []}, {"i": "EC:1.14.11.71", "l": "\"methylphosphonate hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57453", "l": "L-glutaminyl-[protein] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0005006", "l": "epidermal growth factor receptor activity", "d": ["Combining with an epidermal growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46462", "l": "(22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (22R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47776", "l": "guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33609", "l": "(9Z)-octadecenoyl-CoA + AMP + diphosphate => (9Z)-octadecenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061653", "l": "ISG15 conjugating enzyme activity", "d": ["Isoenergetic transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both the X-ISG15 and Y-ISG15 linkages are thioester bonds between the C-terminal amino acid of ISG15 and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73982", "l": "(2E,6E)-farnesyl diphosphate <=> calarene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55231", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29151", "l": "3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out) = 3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18257", "l": "coproporphyrinogen III + 2 H(+) + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX", "d": []}, {"i": "EC:1.3.3.3", "l": "\"coproporphyrinogen oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56156", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050246", "l": "questin monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + questin = demethylsulochrin + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.1", "l": "\"acylaminoacyl-peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418082", "l": "Dissociation of telomerase RNP from the extended chromosomal end (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16349", "l": "AH2 + chlorate = A + chlorite + H2O", "d": []}, {"i": "EC:1.97.1.1", "l": "\"chlorate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57344", "l": "3-hydroxy-D-kynurenine + S-adenosyl-L-methionine = 3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61204", "l": "L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal = H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36232", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47169", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679775", "l": "COMT binds COMT Inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799409", "l": "HIPK2 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12466", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP => myo-inositol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37250", "l": "H2O + thymidine 3'-monophosphate <=> phosphate + thymidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5685230", "l": "CHEK1 phosphorylates RAD51 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25263", "l": "2-oxoglutarate + FADH2 => 2-hydroxyglutarate + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645598", "l": "RRAGC,D hydrolyzes GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874979", "l": "ACBD3 binds GOLGB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5226979", "l": "ADD1:ADD2 binds DMTN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38000", "l": "2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine => H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60055", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 <=> a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34806", "l": "2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA <=> bisdemethoxycurcumin + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865454", "l": "CBFB binds RUNX3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32237", "l": "AMP + H(+) + NADPH + phosphate => (6S)-NADPHX + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41000", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671737", "l": "p-T774-PKN1 binds CDC25C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0016664", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein."]}, {"i": "EC:1.7.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75803", "l": "butanoate(out) + Na(+)(out) = butanoate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25424", "l": "diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11351", "l": "arsenite(in) + ATP + H2O <=> ADP + arsenite(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38596", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59505", "l": "cholesterol + glycyl-L-cysteinyl-[protein] + H(+) => [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59580", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester = CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24210", "l": "1,5-anhydro-D-fructose + H(+) + NADPH => 1,5-anhydro-D-mannitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23182", "l": "a ketone + H2O2 => a secondary alcohol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54422", "l": "5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+) => 3',3'-c-di-AMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797090", "l": "CCNK binds CDK12 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44146", "l": "CoA + H(+) + N(alpha)-acetyl-L-methionine => acetyl-CoA + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.12.2", "l": "\"mitogen-activated protein kinase kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30974", "l": "7,7',9,9'-tetra-cis-lycopene <=> all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5685230", "l": "CHEK1 phosphorylates RAD51 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51571", "l": "(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66787", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out) <=> 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10181", "l": "(6S)-10-formyltetrahydrofolate + H2O + NADP(+) => (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52635", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP <=> [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102059", "l": "2-cis,6-cis-farnesyl pyrophosphate synthase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate + 2 isopentenyl diphosphate <=> 2 diphosphate + (2Z,6Z)-farnesyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45165", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28184", "l": "(1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate => (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18485", "l": "6-acetyl-D-glucose + H2O = acetate + D-glucose + H(+)", "d": []}, {"i": "EC:3.1.1.33", "l": "\"6-acetylglucose deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944232", "l": "Association of procollagen type XII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198669", "l": "p38MAPK phosphorylates MSK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000310", "l": "AURKA phosphorylates PLK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16145", "l": "CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}, {"i": "EC:1.14.18.2", "l": "\"CMP-N-acetylneuraminate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51961", "l": "(Z)-2-methylpropanal oxime => 2-methylpropanenitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48997", "l": "3-methylcatechol + O2 => 2-hydroxy-6-oxo-2,4-heptadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63125", "l": "H2O + N-octadecanoyl ethanolamine => ethanolamine + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10008", "l": "[protein]-dithiol + a hydroperoxide = [protein]-disulfide + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388829", "l": "SHP2 phosphatase binds CTLA-4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684140", "l": "ATM phosphorylates RBBP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3364014", "l": "Recruitment of SET1 methyltransferase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70873", "l": "L-glutamine(out) + L-valine(in) + Na(+)(in) => L-glutamine(in) + L-valine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24489", "l": "H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42765", "l": "formate + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => CO2 + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69530", "l": "4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+) => chorismate + H2O + 2 L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156915", "l": "Translocation of ribosome by 3 bases in the 3' direction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50211", "l": "cortisol + NAD(+) <=> cortisone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103000", "l": "UDP-glucose:4-hydroxylamino-2,6-dinitrotoluene-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 4-hydroxylamino-2,6-dinitrotoluene <=> 4-hydroxylamino-2,6-dinitrotoluene-O-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794336", "l": "NMDAR binds PSD-95 subfamily members (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34816", "l": "2 NADP(+) + tetrahydrocurcumin => curcumin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60512", "l": "a guanosine in miRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200908", "l": "Nef Binds and activates the Src-family tyrosine kinase Fyn (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50971", "l": "adenosine(37) in tRNA(Ala) + H(+) + H2O <=> inosine(37) in tRNA(Ala) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45932", "l": "2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.5", "l": "\"bacterial ABC-type protein transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21834", "l": "3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24554", "l": "cholest-4-en-3-one + H(+) + NADPH => 5alpha-cholestan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52548", "l": "L-threonate + NAD(+) = 2-dehydro-L-erythronate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.411", "l": "\"L-threonate 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031856", "l": "Sulfido conjugates translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029690", "l": "Caspase-6 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59411", "l": "H2O + N-acetyl-L-aspartate <=> acetate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63883", "l": "2 Fe(III)-[cytochrome c] + H2O + thiocyanate <=> cyanate + 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26042", "l": "beta-D-fructose 6-phosphate + GDP-alpha-D-mannose <=> beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57559", "l": "(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19714", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187588", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65498", "l": "3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+) => 3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103118", "l": "UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity", "d": ["Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + an (3R)-3-hydroxymyristoyl-[acp] <=> UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + H+ + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42600", "l": "AH2 + prostaglandin G2 = A + H2O + prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009028", "l": "tartronate-semialdehyde synthase activity", "d": ["Catalysis of the reaction: 2 glyoxylate + H+ = 2-hydroxy-3-oxopropanoate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730902", "l": "Oligomerization of p-CARMA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51493", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58983", "l": "citral + H2O + O2 <=> 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015139", "l": "alpha-ketoglutarate transmembrane transporter activity", "d": ["Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle."]}, {"i": "REACT:R-HSA-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855375", "l": "PTPN22 dissociates from CSK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167427", "l": "Opioid dissociates from MOR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17140", "l": "prostaglandin H2 <=> thromboxane A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247843", "l": "secretion of WNT ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73193", "l": "(2R,3S,11R)-acetylaszonalenin + CoA => (2R,3S,11R)-aszonalenin + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63361", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2 => (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41717", "l": "a 2-acyl-sn-glycero-3-phospho-L-serine + H2O => a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729500", "l": "SARS-CoV-2 N binds to 14-3-3 proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66289", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24782", "l": "CO2 + pyropheophorbide a => C-13(2)-carboxypyropheophorbide a + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031964", "l": "beta-alanyl-histamine hydrolase activity", "d": ["Catalysis of the reaction: N-beta-alanyl histamine + H2O = histamine + beta-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36178", "l": "1-O-alkylglycerone 3-phosphate + H(+) + NADPH <=> 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209185", "l": "Monomeric PGN bound PGRP-LCx heterodimerises with PGRP-LCa at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53211", "l": "daidzein + O2 + reduced [NADPH--hemoprotein reductase] <=> 2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1878002", "l": "XYLTs transfer Xyl to core protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624956", "l": "PDE6D binds INPP5E (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034028", "l": "5-(carboxyamino)imidazole ribonucleotide synthase activity", "d": ["Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134953", "l": "DHX36 or DHX9 binds MyD88 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5221061", "l": "TDG excises 5-carboxylcytosine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66019", "l": "bromide + H2O2 <=> H2O + hypobromite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48824", "l": "GDP-beta-L-fucose + Lc4Cer = a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37945", "l": "12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693598", "l": "ATM phosphorylates NBN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0003870", "l": "5-aminolevulinate synthase activity", "d": ["Catalysis of the reaction: glycine + H+ + succinyl-CoA = 5-aminolevulinate + CO2 + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247840", "l": "WLS binds WNT ligands in the Golgi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51616", "l": "ATP + formate + H(+) = CO2 + dATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0030557", "l": "tRNA modification guide activity", "d": ["Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55601", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose => a mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54311", "l": "pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14059", "l": "a monoacylglycerophospholipid + a triacyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + a glycerophospholipid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0019863", "l": "IgE binding", "d": ["Binding to an immunoglobulin of the IgE isotype."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160079", "l": "metabotropic glycine receptor activity", "d": ["Combining with glycine and transmitting the signal across the membrane by changing the activity of intracellular G protein signalling."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20991", "l": "ATP + 2 H2O <=> AMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55198", "l": "formyl-CoA + heptadecanal => 2-hydroxyoctadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2219524", "l": "PDPK1 binds PIP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204861", "l": "Interaction of Tie2 and Shc1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0035594", "l": "ganglioside binding", "d": ["Binding to a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.879406879579491", "identifiers": [{"i": "GO:0004175", "l": "endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37036", "l": "H2O + L-2-aminopentanoate + NAD(+) => 2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201515", "l": "Active ALK recruits PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20740", "l": "H2O + trans-2,3-epoxysuccinate = (2R,3S)-tartrate", "d": []}, {"i": "EC:3.3.2.4", "l": "\"trans-epoxysuccinate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047161", "l": "tartronate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: hydroxymalonate + sinapoyl-CoA = CoA + sinapoyltartronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750226", "l": "NLRC5 binds IKBKB and CHUK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74334", "l": "O-butanoyl-(R)-carnitine(in) <=> O-butanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55843", "l": "calcidiol + UDP-alpha-D-glucuronate <=> calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004077", "l": "biotin-[acetyl-CoA-carboxylase] ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming))."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821931", "l": "BOD1L1 binds SET1A complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120152", "l": "calcium-dependent outer dynein arm binding", "d": ["Binding to an outer dynein arm in the presence of calcium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72138", "l": "putrescine(out) <=> putrescine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68542", "l": "(-)-alpha-cedrene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.48", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210837", "l": "HNF6-dependent synthesis of ONECUT3 protein during morphogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43729", "l": "methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38954", "l": "ATP + H2O + sphing-4-enine 1-phosphate(in) <=> ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416358", "l": "G alpha (q) inhibits PI3K alpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2168886", "l": "Hemopexin binds Hemes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41521", "l": "menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617182", "l": "PRKACA phosphorylates PLN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65520", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42333", "l": "ATP + L-glutamate + oxidized coenzyme F420-2 => ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807585", "l": "BPI binds LPS on the bacterial surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60900", "l": "a cytidine in RNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69763", "l": "a medium-chain fatty aldehyde + H2O + NAD(+) = a medium chain fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26220", "l": "abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050205", "l": "oxamate carbamoyltransferase activity", "d": ["Catalysis of the reaction: carbamoyl phosphate + oxamate = oxalurate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802927", "l": "BRAF and RAF fusion mutant dimers are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061784", "l": "peptidoglycan N-acetylglucosaminidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) from peptidoglycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30553", "l": "6-O-acetyl-beta-D-glucose + CoA => acetyl-CoA + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879274", "l": "acetylglucosamine-inositol-phosphate is dephosphorylated (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53543", "l": "(13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O <=> (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70124", "l": "3-dehydro-6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 6-dehydro-28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.239", "l": "\"3alpha-(17beta)-hydroxysteroid dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222655", "l": "AhpD reactivates AhpC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102547", "l": "glucosylglycerate hydrolase activity", "d": ["Catalysis of the reaction: H2O + 2-O-(alpha-D-glucopyranosyl)-D-glycerate <=> alpha-D-glucose + D-glycerate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373739", "l": "Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033412", "l": "UAG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UAG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209097", "l": "ARM binds to APC and AXN in the 'destruction complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34721", "l": "(2E)-13-methyltetradecenal + phosphoethanolamine => 15-methylhexadecasphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62918", "l": "an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine => an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66355", "l": "(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+) <=> (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786789", "l": "FLT3LG dimer binds FLT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944257", "l": "Association of procollagen type XXIV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102386", "l": "phenylacetaldehyde reductase activity", "d": ["Catalysis of the reaction: 2-phenylethanol + NADP = phenylacetaldehyde + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18192", "l": "[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41065", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43736", "l": "adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.266", "l": "\"23S rRNA (adenine(2030)-N(6))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75491", "l": "25-hydroxyvitamin D3 sulfate(out) + n H(+)(out) = 25-hydroxyvitamin D3 sulfate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15485", "l": "(2R,3S)-homoisocitrate = cis-homoaconitate + H2O", "d": []}, {"i": "EC:4.2.1.36", "l": "\"homoaconitate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854222", "l": "TBC1D3 associates with RAB5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694563", "l": "ABHD10 hydrolyses MPAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44789", "l": "2-demethylmenaquinol-11 + S-adenosyl-L-methionine => H(+) + menaquinol-11 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19797", "l": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2172678", "l": "PHF8 demethylates histone H4K20me1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56973", "l": "(R)-3-hydroxy-2-methylpropanoate + NAD(+) => (R)-methylmalonate semialdehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37828", "l": "(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 => 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51775", "l": "dimethylallyl diphosphate + phlorisobutanophenone <=> 4-prenylphlorisobutanophenone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9658253", "l": "RAS:GTP binds PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046576", "l": "rhamnogalacturonan alpha-L-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronide lyase activity", "d": ["Catalysis of the cleavage of rhamnogalacturonan, generating oligosaccharides of the form alpha-D-us-galacturonic acid-(1,2)-alpha-L-rhamnose-(1,4)-alpha-D-galacturonate-(1,2)-L-rhamnose-(1,2)-alpha-L-rhamnose-p-(1,4)-alpha-D-galacturonic acid, terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28059", "l": "L-lyxopyranose => L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.9.1", "l": "\"pyruvate, phosphate dikinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42453", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate => H2O + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75445", "l": "heme b(out) => heme b(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9006873", "l": "IL21 receptor STAT binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43035", "l": "3-chloro-D-alanine <=> 2-aminoprop-2-enoate + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73910", "l": "4-hydroxy-N,N,N-trimethyltryptamine + ATP <=> ADP + aeruginascin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202174", "l": "Activation of ZAP-70 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60093", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) => 3-dehydro-4alpha-methylzymosterol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39038", "l": "an omega-hydroxy fatty acid + NAD(+) <=> an omega-oxo fatty acid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102896", "l": "colnelenate synthase activity", "d": ["Catalysis of the reaction: (10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate <=> colnelenate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75697", "l": "2'-deoxycytidine(out) => 2'-deoxycytidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63827", "l": "2 3-(4-hydroxyphenyl)pyruvate <=> aspulvinone E + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109813", "l": "GRB2-1 binds SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30530", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate <=> ADP + ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.105", "l": "\"2-methylene-furan-3-one reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985594", "l": "MYO9B inactivates RHOA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40162", "l": "H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52251", "l": "6 H2O + 4 Mn(3+) + O2 <=> 12 H(+) + 4 MnO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56513", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008832", "l": "dGTPase activity", "d": ["Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20756", "l": "(E)-caffeoyl-CoA + D-threo-isocitrate = 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA", "d": []}, {"i": "EC:2.3.1.126", "l": "\"isocitrate O-dihydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375384", "l": "Bombesin-like receptors bind bombesin homologues (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008137", "l": "RUNX2 binds ZNF521 and HDAC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38193", "l": "17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57967", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49130", "l": "5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine => AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9007901", "l": "IL1F10 binds IL1RL2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.48", "l": "\"RNA-directed RNA polymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54791", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide <=> [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987120", "l": "JAK1 binds IFNLR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47801", "l": "4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid => an aromatic oxo-acid + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18566", "l": "19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine => 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64723", "l": "H(+)(out) + pyruvate(out) <=> H(+)(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36832", "l": "2 caldariellaquinol + n H(+)(in) + O2 => 2 caldariellaquinone + n H(+)(out) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014296", "l": "RAC2 GEFs activate RAC2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17766", "l": "(2R)-3-phospho-glyceroyl phosphate => (2R)-2,3-bisphosphoglycerate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47698", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686335", "l": "CSF2RA:CSF2RB binds SFTPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29675", "l": "glycerol(in) = glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19740", "l": "4-(gamma-L-glutamylamino)butanoate + H2O <=> 4-aminobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55208", "l": "(4R)-hydroxysphinganine 1-phosphate = (2R)-hydroxyhexadecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3296301", "l": "CCRL2 binds CCL19 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68904", "l": "3-phenylpropanoate + ATP + H(+) + NADPH = 3-phenylpropanal + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0005003", "l": "ephrin receptor activity", "d": ["Combining with an ephrin receptor ligand to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10970", "l": "an acyl-CoA + GDP + phosphate => a carboxylate + CoA + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19890", "l": "alpha-D-glucose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26265", "l": "dehydroabietadienal + H2O + NADP(+) = dehydroabietate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562603", "l": "BfrB stores iron (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158860", "l": "SULT1A1 dimer sulfonates NHABP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44726", "l": "(2E)-fatty aldehyde + H(+) + NADPH => 2,3-saturated fatty aldehyde + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65390", "l": "a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53452", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62310", "l": "(+)-malbrancheamide B + FADH2 => (+)-premalbrancheamide + chloride + FAD + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200396", "l": "Creatine transport across the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870269", "l": "Gastrin binds to CCK-B receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58404", "l": "hexan-1-ol + NADP(+) = H(+) + hexanal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-996727", "l": "REST recruits the BHC complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754129", "l": "CDK6 inhibitors bind CDK6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34478", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate <=> 15-cis-phytoene + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4332236", "l": "CBL neddylates TGFBR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69168", "l": "H2O + NAD(+) + spermine monoaldehyde = 2 H(+) + N-(2-carboxyethyl)spermidine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051435", "l": "BH4 domain binding", "d": ["Binding to a BH4 protein domain, present in Bcl-2 family members. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71303", "l": "RPE dimers isomerise RU5P to XY5P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18754", "l": "[protein]-dithiol + NADP(+) => [protein]-disulfide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70606", "l": "4-hydroxystyrene + H(+) + NADH <=> 4-ethylphenol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38598", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33523", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O = acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193665", "l": "MYD88 dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70816", "l": "H(+)(in) + L-histidine(in) + L-ornithine(out) => H(+)(out) + L-histidine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951727", "l": "cAMP binds PKA tetramer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65687", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine <=> a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62783", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47207", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69806", "l": "ATP + benzoate + H(+) <=> benzoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62160", "l": "H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate = N-(9Z-octadecenoyl) ethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25218", "l": "acetyl-CoA + serotonin => CoA + H(+) + N-acetylserotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9681616", "l": "AP2 binds chlorpromazine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74474", "l": "(-)-4'-methoxycyclopeptine + 2-oxoglutarate + O2 <=> (Z)-4'-methoxydehydrocyclopeptine + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683325", "l": "Defective ABCD4:LMBRD1 does not transport Cbl from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357479", "l": "p-AXL binds PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000100", "l": "S-methylmethionine transmembrane transporter activity", "d": ["Enables the transfer of S-methylmethionine from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40656", "l": "(R)-malate + succinyl-CoA => (R)-malyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14603", "l": "5-aminopentanamide + CO2 + H2O => L-lysine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63385", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62581", "l": "ATP + D-cystine(out) + H2O => ADP + D-cystine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10223", "l": "ATP + L-tyrosine + tRNA(Tyr) <=> AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31266", "l": "but-3-ynal + H(+) + pyrroloquinoline quinol <=> but-3-yn-1-ol + pyrroloquinoline quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466369", "l": "NRF1:PPARGC1B binds the ATP5B promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13253", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676229", "l": "WIPIs bind PI3P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64399", "l": "glycyl-sarcosine(out) + H(+)(out) <=> glycyl-sarcosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23237", "l": "[protein]-L-glutamate 5-O-methyl ester + H2O => H(+) + L-glutamyl-[protein] + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38824", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102644", "l": "monocyclic sesterterpenediol synthase activity", "d": ["Catalysis of the reaction: monocyclic sesterterpenediol <=> all-trans-geranylfarnesol + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60962", "l": "(9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP => 18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64757", "l": "H2O + S-benzyl-L-cysteine => benzylthiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34488", "l": "dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol => alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264622", "l": "Cho is acetylated to AcCho by CHAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183072", "l": "EGFR non-clathrin mediated endocytosis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70299", "l": "H2O + L-dehydroascorbate = 2,3-dioxo-L-gulonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021520", "l": "NOTCH3 binds WWP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11692", "l": "NAD(+) + NADPH = NADH + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42061", "l": "11-cis-retinol + NAD(+) => 11-cis-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37131", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015496", "l": "putrescine:ornithine antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.214", "l": "\"2-dehydropantolactone reductase (Si-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189406", "l": "4 PBGs bind to form HMB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12412", "l": "(2R)-3-phosphoglycerate + H2O = (R)-glycerate + phosphate", "d": []}, {"i": "EC:3.1.3.38", "l": "\"3-phosphoglycerate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15158", "l": "4-hydroxyphenylacetate + H(+) + NADPH + O2 => H2O + homogentisate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70817", "l": "H(+)(out) + L-histidine(out) + L-ornithine(in) => H(+)(in) + L-histidine(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0030547", "l": "signaling receptor inhibitor activity", "d": ["Binds to and modulates the activity of a signaling receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29862", "l": "5'-deoxyadenosine + H2O <=> 5-deoxy-D-ribose + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15181", "l": "an acyl-CoA(out) + ATP + H2O = ADP + an acyl-CoA(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.6.2.4", "l": "\"ABC-type fatty-acyl-CoA transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176318", "l": "Loading of claspin onto DNA during replication origin firing (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047834", "l": "D-threo-aldose 1-dehydrogenase activity", "d": ["Catalysis of the reaction: a D-threo-aldose + NAD+ = a D-threo-aldono-1,5-lactone + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850831", "l": "KLK5 cleaves and activates KLK8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56013", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36015", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27991", "l": "1-deoxy-D-xylulose + ATP => 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21369", "l": "H2O + O2 + urate => 5-hydroxyisourate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5262606", "l": "XAV939 binds tankyrase to stabilize axin and inhibit WNT signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57508", "l": "H2O + NADP(+) + staphylopine = (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": []}, {"i": "EC:1.5.1.52", "l": "\"staphylopine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66785", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out) => 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649483", "l": "Defective PAH does not hydroxylate L-Phe to L-Tyr (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:1905538", "l": "polysome binding", "d": ["Binding to a polysome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661425", "l": "BIL:ALB dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031419", "l": "cobalamin binding", "d": ["Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49852", "l": "(3E)-octenoyl-CoA = (2E)-octenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800380", "l": "PTPRD binds IL1RAP-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55611", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39654", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O <=> 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164840", "l": "ADP and Pi bind to ATPase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683774", "l": "p-T68-CHEK2 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36611", "l": "(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 = (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate", "d": []}, {"i": "EC:1.14.20.3", "l": "\"(5R)-carbapenem-3-carboxylate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31412", "l": "a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5622129", "l": "FABP5 binds atRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52056", "l": "12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33971", "l": "5''-phosphoribostamycin + H2O = phosphate + ribostamycin", "d": []}, {"i": "EC:3.1.3.88", "l": "\"5''-phosphoribostamycin phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27671", "l": "1D-myo-inositol 1-phosphate + H2O => myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578777", "l": "DMPK phosphorylates PLN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14918", "l": "3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] => 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848818", "l": "PTK6 phosphorylates CBL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69196", "l": "ATP + L-glutamate + L-glutamyl-[beta-tubulin] = ADP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14997", "l": "deoxylimonoate + H2O = deoxylimononate D-ring-lactone + H(+)", "d": []}, {"i": "EC:3.1.1.46", "l": "\"deoxylimonate A-ring-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64253", "l": "glycine + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21229", "l": "alpha-maltose => beta-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8867344", "l": "OMA1 hydrolyses OPA1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46797", "l": "an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655193", "l": "KIAA0101 double monoubiquitination (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030151", "l": "molybdenum ion binding", "d": ["Binding to a molybdenum ion (Mo)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15373", "l": "columbamine + S-adenosyl-L-methionine = H(+) + palmatine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.118", "l": "\"columbamine O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0070273", "l": "phosphatidylinositol-4-phosphate binding", "d": ["Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48564", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27611", "l": "formate + H(+) => CO2 + H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706837", "l": "AR binds AR antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40956", "l": "(R)-5-phosphomevalonate + ATP => ADP + CO2 + isopentenyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12583", "l": "H2O + NAD(+) + tauropine <=> H(+) + NADH + pyruvate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11982", "l": "bis-gamma-glutamylcystine + H(+) + NADPH => 2 gamma-L-glutamyl-L-cysteine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49906", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2 => (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995334", "l": "COX15 transforms heme O to heme A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209738", "l": "VD3 binds GC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10820", "l": "D-threo-isocitrate = D-erythro-isocitrate", "d": []}, {"i": "EC:5.1.2.6", "l": "\"isocitrate epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113643", "l": "Replication initiation regulation by Rb1/E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709831", "l": "HSP90 binds TBK1 and IRF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54443", "l": "a (4S)-2,3-dehydroflavan-3,4-diol + H(+) <=> a 4-H-anthocyanidin with a 3-hydroxy group + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.40", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45601", "l": "D-galactaro-1,4-lactone => 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64586", "l": "2-hydroxyethane-1-sulfonate(in) + Na(+)(in) => 2-hydroxyethane-1-sulfonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71570", "l": "5-phosphomethyl-dUMP in DNA + L-serine <=> 5-O-(L-seryl)-dTMP in DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804253", "l": "MDM2 ubiquitinates JMY (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611751", "l": "β1,2-agonists bind ADRB1,2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58462", "l": "a monoacyl-sn-glycero-3-phosphocholine + CoA => an acyl-CoA + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694542", "l": "nsp14 binds nsp10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51607", "l": "2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36820", "l": "(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786789", "l": "FLT3LG dimer binds FLT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22350", "l": "imidazol-4-one + NH4(+) => 4-aminoimidazole + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50246", "l": "3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44933", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202164", "l": "Translocation of PDK1 to Plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14143", "l": "adenosine 5'-phosphosulfate + 2 glutathione => AMP + glutathione disulfide + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64210", "l": "a fatty acid + L-glutamine => an N-(fatty acyl)-L-glutamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38250", "l": "(9Z)-hexadecenoyl-CoA + hexadecan-1-ol <=> 1-O-hexadecyl (9Z)-hexadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814096", "l": "ARL1:GTP binds SCOC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918224", "l": "DDX58 is K63 polyubiquitinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706344", "l": "FLT3 phosphorylates GRB10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788061", "l": "Fibronectin degradation by ADAM8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228941", "l": "Transcytosis and dissociation of botE:NTNHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47618", "l": "ethionamide S-oxide + H2O + NADP(+) => ethionamide + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17734", "l": "acetylenedicarboxylate + H(+) + H2O => CO2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679775", "l": "COMT binds COMT Inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48986", "l": "2,4-dichlorophenol + CO2 + glyoxylate + succinate => (2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39014", "l": "a triacyl-sn-glycerol(in) <=> a triacyl-sn-glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63021", "l": "(9Z,12Z)-octadecadienamide + H2O => (9Z,12Z)-octadecadienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169395", "l": "ISGylation of viral protein NS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45330", "l": "7,8-dihydromonapterin => 7,8-dihydroneopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42142", "l": "a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870466", "l": "RGGT:CHM binds RABs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009558", "l": "IL34 dimer binds SDC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14118", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O => [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69596", "l": "AMP + inosine = adenosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46520", "l": "an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202241", "l": "Recruitment of SLP-76 to Gads (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62230", "l": "AH2 + patulin => (E)-ascladiol + A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140294", "l": "NAD DNA ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27645", "l": "adenosine + phosphate <=> adenine + alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30512", "l": "2-demethylmenaquinone-8 + H(+) + NADPH => 2-demethylmenaquinol-8 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71661", "l": "a 3-dehydro-D-glucoside + 2 Fe(II)-[cytochrome c] + 2 H(+) => a D-glucoside + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38342", "l": "(20S)-ginsenoside Rb1 + H2O <=> (20S)-ginsenoside Rd + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.2.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46709", "l": "2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase] => AMP + H(+) + salicyl-[non-ribosomal peptide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862733", "l": "CCR2, CCR3 bind CCL13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50118", "l": "CoA + H(+) + N-eicosanoyl-taurine => eicosanoyl-CoA + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41016", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol => 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41875", "l": "3-oxododecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxydodecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030755", "l": "quercetin 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxy-flavone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61616", "l": "H(+) + L-proline betaine + NADH + O2 = formaldehyde + H2O + N-methyl-L-proline + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205118", "l": "TRAF6 polyubiquitinates NRIF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670436", "l": "p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14515", "l": "ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate => ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32825", "l": "phosphate(out) => phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675473", "l": "SH2B binds JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35135", "l": "L-alanyl-L-glutamate(out) = L-alanyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620788", "l": "FOXO1,FOXO3,FOXO4 binds RBL2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451439", "l": "Activated TLR7 or 21 recruits MyD88 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25006", "l": "L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53225", "l": "16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52976", "l": "a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] = a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68654", "l": "H(+) + hydrogen sulfide + L-homolanthionine => 2 L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51175", "l": "cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0019202", "l": "amino acid kinase activity", "d": ["Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686731", "l": "TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416516", "l": "GRK2 sequesters activated Gq (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635804", "l": "ATF4 and phospho-ATF2 bind the DDIT3 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47328", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53605", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67231", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA <=> (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64366", "l": "(15S)-15-hydroperoxy-prostaglandin E2 => prostaglandin G2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005461", "l": "UDP-glucuronic acid transmembrane transporter activity", "d": ["Enables the transfer of a UDP-glucuronic acid from one side of a membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73114", "l": "S-adenosyl-L-methionine + scutellarein 4'-methyl ether <=> ladanein + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034550", "l": "dimethylarsinate reductase activity", "d": ["Catalysis of the reaction: dimethylarsinate + 3 H+ + 2 e- = dimethylarsinous acid + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047691", "l": "aspulvinone dimethylallyltransferase activity", "d": ["Catalysis of the reaction: aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164381", "l": "G alpha (s) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73350", "l": "beta-alanyl-[peptidyl-carrier protein] + tryptamine <=> beta-alanyl-tryptamine + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388605", "l": "POMC(138-176) binds MC2R (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450387", "l": "HuR binds the CRM1 nuclear export machinery (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799431", "l": "TP53 binds HIPK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53665", "l": "(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+) => H(+) + 2 H2O + pyridinestrone carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983266", "l": "Kinesins bind microtubules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16886", "l": "2 bilirubin-glucuronoside => bilirubin IXalpha + bilirubin-bisglucuronoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63976", "l": "A + dihydropyriculariol = AH2 + pyriculariol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46166", "l": "a quinol + NADP(+) => a quinone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70339", "l": "alpha-D-Gal-(1->6)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O = beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72006", "l": "(S)-lactate(in) + urate(out) <=> (S)-lactate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299297", "l": "Activation of THIK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61052", "l": "(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] = (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928624", "l": "EPHBs bind EFNBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103001", "l": "dimethylsulfoxide oxygenase activity", "d": ["Catalysis of the reaction: dimethyl sulfoxide + O2 + NADPH + H+ <=> sulfonyldimethane + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20551", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + tetrathionate => 2 Fe(III)-[cytochrome c] + 2 thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11225", "l": "ATP + 2 D-alanine => ADP + D-alanyl-D-alanine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72947", "l": "acetate(out) + 2 Na(+)(out) = acetate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58270", "l": "[protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide => [protein]-C-terminal glycine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450422", "l": "KSRP recruits RNA degradation activities (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39197", "l": "(3R)-hydroxytetracosanoyl-CoA + NADP(+) => 3-oxotetracosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43426", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68775", "l": "(2Z,6Z)-farnesyl diphosphate <=> diphosphate + germacrene C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665767", "l": "Activated FMNL3 binds G-actin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49515", "l": "2-(phosphinatomethylidene)butanedioate + H2O <=> phosphinomethylisomalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28353", "l": "UDP-beta-L-arabinofuranose <=> UDP-beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37105", "l": "(N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45198", "l": "5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+) => 5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47184", "l": "5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58889", "l": "4-aminobenzoate + AH2 + 2 O2 => 4-nitrobenzoate + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29396", "l": "H2O + UTP => diphosphate + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168299", "l": "Ribonucleoprotein release from M1 proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3828025", "l": "DCN (decorin) degradation by MMP14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71303", "l": "RPE dimers isomerise RU5P to XY5P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28599", "l": "H2O + N-acetyl-L-lysine => acetate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.42", "l": "\"cathepsin O\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37144", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67671", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667111", "l": "PARK2 K63-Ubiquitinates SNCAIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433711", "l": "Cis-homodimerization of nectins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31137", "l": "5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676160", "l": "AAMP binds NOD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48458", "l": "2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate => 1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42997", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (R)-cembrene A + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10033", "l": "[protein]-C-terminal-L-glutamine + H2O => [protein]-C-terminal-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6794347", "l": "Homer1,2,3 dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213200", "l": "Release of endostatin-like peptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678854", "l": "S1PR1 binds S1PR1 agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172678", "l": "PHF8 demethylates histone H4K20me1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727188", "l": "ATP4A:ATP4B binds PPIs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19775", "l": "D-glyceraldehyde 3-phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141038", "l": "phosphatidylinositol 3-kinase activator activity", "d": ["Binds to and increases the activity of a phosphatidylinositol 3-kinase (PI3K)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549322", "l": "OCT1 transports organic cations out of hepatic cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42428", "l": "clavaminate = (3R,5R)-clavulanate-9-aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688838", "l": "RIPK3 binds STUB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434650", "l": "MATEs mediate extrusion of xenobiotics (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57870", "l": "(E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate => (E)-4-coumaroyl-CoA + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809663", "l": "Formation of hair keratin fibres (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047118", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity", "d": ["Catalysis of the reaction: 2,6-dioxo-6-phenylhexanoate + NADP+ = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65452", "l": "ethanol + hexanoyl-CoA = CoA + ethyl hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36915", "l": "(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63726", "l": "candesartan O-beta-D-glucuronoside + UDP => candesartan + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68037", "l": "(S)-cystathionine ketimine + 2 H(+) + NADPH => (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54222", "l": "all-trans-neurosporene + H2O => 1-hydroxy-all-trans-1,2-dihydro-neurosporene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11262", "l": "H2O2 + NADP(+) => H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950778", "l": "p-Y693-STAT4 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46639", "l": "5beta-dihydrotestosterone + NADP(+) <=> H(+) + NADPH + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5444523", "l": "Formation of MSH1:PMS2 Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25039", "l": "ADP + O-phospho-L-seryl-tRNA(Sec) => ATP + L-seryl-tRNA(Sec)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433542", "l": "Phosphorylation and activation of VAV1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49888", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 = (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17116", "l": "H2O + L-serine-phosphoethanolamine <=> H(+) + L-serine + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008766", "l": "UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity", "d": ["Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76494", "l": "POR reduces CYP450:Fe3+ to CYP450:Fe2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23785", "l": "a quinone + L-proline => (S)-1-pyrroline-5-carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47762", "l": "a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in 21S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60335", "l": "L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.191", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43429", "l": "1,2-didecanoyl-sn-glycerol + ATP => 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434989", "l": "SEMA7A binds to PLXNC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848023", "l": "Activated PTK6 binds STAP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0002020", "l": "protease binding", "d": ["Binding to a protease or a peptidase."]}, {"i": "REACT:R-HSA-1297354", "l": "Acrosin Cleavage (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71251", "l": "L-xylopyranose = L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19979", "l": "adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate => 3'-phosphoadenylyl sulfate + L-tyrosine methyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389955", "l": "Beta-tubulin:GTP: Cofactor A+ Cofactor D ->  Beta-tubulin:GTP:Cofactor D + Cofactor A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65091", "l": "asperaculane E + O2 + reduced [NADPH--hemoprotein reductase] <=> asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109807", "l": "GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45321", "l": "H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine => H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-445072", "l": "Interaction of PAK1 with Rac1-GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873923", "l": "STARD10 binds LPCAT1 and PC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19489", "l": "dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide = 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696457", "l": "BDH2 dehydrogenates 3HBA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44622", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30087", "l": "(S)-2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68094", "l": "a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+) => a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51430", "l": "2-N-acetamidomethylphosphonate + CoA => acetyl-CoA + aminomethylphosphonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380008", "l": "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53804", "l": "allodeoxycholoyl-CoA + ursodeoxycholate = allodeoxycholate + ursodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72102", "l": "Na(+)(out) + O-acetyl-(R)-carnitine(out) <=> Na(+)(in) + O-acetyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74404", "l": "2 (S)-lactate(in) + prostaglandin D2(out) => 2 (S)-lactate(out) + prostaglandin D2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606789", "l": "ARSB hydrolyses DS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-517705", "l": "p-S318,221-HuR binds mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48442", "l": "a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34787", "l": "a 3beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061575", "l": "cyclin-dependent protein serine/threonine kinase activator activity", "d": ["Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59060", "l": "(20S)-ginsenoside Rg3 + H2O = (20S)-ginsenoside Rh2 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38187", "l": "19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase] = 17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.51", "l": "\"3(or 17)beta-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9724290", "l": "GNRHR2 binds GNRH1,2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72309", "l": "L-glutamate(out) + taurocholate(in) => L-glutamate(in) + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25446", "l": "(1E,4E)-germacrene B + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0061609", "l": "fructose-1-phosphate aldolase activity", "d": ["Catalysis of the reaction: D-fructose-1-phosphate = dihydroxyacetone phosphate + D-glyceraldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69124", "l": "glyoxylate + L-tryptophan = glycine + indole-3-pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664332", "l": "CREB1 binds IL-10 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74767", "l": "S-adenosyl-L-methionine + syringetin = 3,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5669012", "l": "EDA binds EDAR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-606349", "l": "Mis18 complex binds the centromere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70555", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O = L-seryl-[protein] + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250930", "l": "B-WICH recruits histone acetyltransferases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20467", "l": "H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP => [hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070300", "l": "phosphatidic acid binding", "d": ["Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35361", "l": "(2E)-15-methylhexadecenoyl-CoA + H2O => 3-hydroxyisoheptadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67091", "l": "ATP + H2O + tetracosanoate(in) <=> ADP + H(+) + phosphate + tetracosanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047239", "l": "hydroxymandelonitrile glucosyltransferase activity", "d": ["Catalysis of the reaction: 4-hydroxymandelonitrile + UDP-D-glucose = H+ + taxiphyllin + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62146", "l": "2 dGDP => dGMP + dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25277", "l": "3',5'-cyclic AMP + H2O = AMP + H(+)", "d": []}, {"i": "EC:3.1.4.53", "l": "\"3',5'-cyclic-AMP phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17085", "l": "4-pyridoxate + A = 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2", "d": []}, {"i": "EC:1.1.99.42", "l": "\"4-pyridoxate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047371", "l": "butyrate-acetoacetate CoA-transferase activity", "d": ["Catalysis of the reaction: acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678843", "l": "ISGylation of protein translation regulator 4EHP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0016297", "l": "acyl-[acyl-carrier-protein] hydrolase activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + a fatty acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990663", "l": "dihydroorotate dehydrogenase (fumarate) activity", "d": ["Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37317", "l": "glycine + L-glutamine => glycyl-L-glutamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647977", "l": "ICMT methylates S-Farn RAS proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607753", "l": "CARD9 oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18156", "l": "2 GTP + H(+) <=> diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72180", "l": "Cleavage of mRNA at the 3'-end (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533965", "l": "NID1 degradation by MMP14, MMP15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48613", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867041", "l": "EGFR phosphorylates EPS15 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.2.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45546", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14524", "l": "(2E)-geraniol + NADP(+) <=> (2E)-geranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34187", "l": "(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72722", "l": "eIF2 activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72774", "l": "7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40461", "l": "(2E)-pristenoyl-CoA + H2O2 => (2S)-pristanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65000", "l": "holo-[ACP] + octanoyl-AMP = AMP + H(+) + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800794", "l": "PIDD1 associates with CRADD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65484", "l": "hexan-1-ol + hexanoyl-CoA = CoA + hexyl hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.945916858897462", "identifiers": [{"i": "GO:0000030", "l": "mannosyltransferase activity", "d": ["Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2990882", "l": "CDK1 phosphorylates NUP98 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68956", "l": "S-adenosyl-L-methionine + scopoletin = H(+) + S-adenosyl-L-homocysteine + scoparone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70229", "l": "(E)-2-benzylidenesuccinyl-CoA + H2O => (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2995334", "l": "COX15 transforms heme O to heme A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854209", "l": "TBC1D10A binds JFC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052794", "l": "exo-alpha-(2->3)-sialidase activity", "d": ["Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14827", "l": "(S)-carvone + H(+) + NADH => (1R,5S)-carveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73914", "l": "ATP + psilocin <=> ADP + H(+) + psilocybin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251562", "l": "Deletions in the AXIN1 gene prevent expression of AXIN1 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65074", "l": "dauca-4,7-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.850581069382244", "identifiers": [{"i": "GO:0016899", "l": "oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31302", "l": "H2O + NAD(+) + perillyl aldehyde <=> 2 H(+) + NADH + perillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071858", "l": "corazonin receptor binding", "d": ["Binding to a corazonin receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140901", "l": "L-asparagine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-asparagine(out) + Na+(out) = L-asparagine(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655142", "l": "RCHY1 binds POLH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983147", "l": "Release of E3 from polyubiquitinated substrate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28221", "l": "chloride + H(+) + H2O2 <=> H2O + hypochlorous acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399711", "l": "Activation of Ca impermeable AMPA receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50005", "l": "H(+) + NADPH + O2 + tetracycline => 11a-hydroxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70923", "l": "(R)-noradrenaline(out) + chloride(out) + Na(+)(out) = (R)-noradrenaline(in) + chloride(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41323", "l": "1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34589", "l": "CO2 + pentalenolactone F + succinate => 2-oxoglutarate + O2 + pentalenolactone E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69346", "l": "(Z)-butanethial oxide => (E)-but-1-en-1-SO-peroxol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002953", "l": "5'-deoxynucleotidase activity", "d": ["Catalysis of the reaction:a 2'-deoxyribonucleoside 5'-monophosphate + H20=a 2'-deoxyribonucleoside + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627369", "l": "SEPT4 binds XIAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39264", "l": "(2E,13Z)-docosadienoyl-CoA + H(+) + NADPH => (13Z)-docosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25462", "l": "diphosphate + sibirene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27786", "l": "2-oxoglutarate + CoA + NAD(+) = CO2 + NADH + succinyl-CoA", "d": []}, {"i": "EC:1.2.1.105", "l": "\"2-oxoglutarate dehydrogenase system\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33917", "l": "H2O2 + methylamine + succinate semialdehyde => 4-(methylamino)butanoate + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61468", "l": "a cytidine in tRNA + S-adenosyl-L-methionine = a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443831", "l": "14-3-3-zeta binds Raf1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374896", "l": "Uptake of Noradrenaline (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952419", "l": "SMURFs ubiquitinate RUNX3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212614", "l": "Glutamine transport from astrocytes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.2", "l": "\"aminopyrimidine aminohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015415", "l": "ATPase-coupled phosphate ion transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphate(out) = ADP + phosphate + phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28159", "l": "alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15224", "l": "a CDP-1,2-diacyl-sn-glycerol + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23557", "l": "D-alanine + L-glutamine => gamma-L-glutamyl-D-alanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33137", "l": "malonate(out) + Na(+)(out) => malonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44350", "l": "ADP + dapdiamide B + H(+) + phosphate => ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174255", "l": "Degradation multiubiquitinated Cyclin A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59674", "l": "D-maltotriono-1,5-lactone + H2O2 => D-maltotriose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30475", "l": "H2O + oroxylin A 7-O-beta-D-glucuronate = D-glucuronate + H(+) + oroxylin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008315", "l": "TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592436", "l": "Initial activation of proMMP9 by MMPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618107", "l": "ATP binding to HSP90 triggers conformation change (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0001221", "l": "transcription coregulator binding", "d": ["Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47579", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) <=> CMP + ganglioside GD1c (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64531", "l": "AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine <=> 2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391913", "l": "FPR2 binds FPR2 ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68889", "l": "2-methoxybenzoate + ATP + H(+) + NADPH => 2-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36146", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADPH <=> hexadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428909", "l": "Activated TP receptor binds G-protein  G13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044023", "l": "histone H4S1 kinase activity", "d": ["Catalysis of the reaction: histone H4-serine (position 1) + ATP = histone H4-phosphoserine (position 1) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 1 of histone H4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749215", "l": "MCM8 binds CDC6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700175", "l": "Active ALK phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52931", "l": "3',3'-c-di-GMP + 2 H2O <=> 2 GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204850", "l": "Interaction of Tie2 and Dok-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10750", "l": "CO2 + H2O => H(+) + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22520", "l": "all-trans-retinal + H2O + O2 = all-trans-retinoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-937192", "l": "Cysteine from cystathionine and vice versa (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430183", "l": "NCK binds PAK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61786", "l": "keto-L-fructose => L-allulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50347", "l": "3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH <=> 3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71377", "l": "2 Na(+)(in) + testosterone 17-sulfate(in) => 2 Na(+)(out) + testosterone 17-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0044183", "l": "protein folding chaperone", "d": ["Binding to a protein or a protein-containing complex to assist the protein folding process."]}, {"i": "REACT:R-HSA-9018785", "l": "RHOBTB2 binds GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852362", "l": "GTSE1 binds CDKN1A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012084", "l": "Constitutive dimerization of FGFR3 cysteine mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390663", "l": "ADRA2A,B,C bind ADR,NAd (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578965", "l": "TNRC6A binds AGO2:miRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047283", "l": "dolichyl-phosphate D-xylosyltransferase activity", "d": ["Catalysis of the reaction: dolichol-phosphate + UDP-D-xylose = dolichyl D-xylosyl phosphate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46418", "l": "(6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866851", "l": "CFTR transits to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168849", "l": "tBID binds to inactive BAX protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867344", "l": "OMA1 hydrolyses OPA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19197", "l": "adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + 2 H(+) + sulfate", "d": []}, {"i": "EC:2.7.7.51", "l": "\"adenylylsulfate--ammonia adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2870221", "l": "E-selectin binds E-selectin ligand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61861", "l": "dehydroprobetaenone I + H(+) + NADPH + O2 => epoxybetaenone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24688", "l": "formate + methanofuran => H2O + N-formylmethanofuran", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34484", "l": "4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA => 4-hydroxybenzalacetone + 2 CO2 + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12452", "l": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.134", "l": "\"inositol-tetrakisphosphate 1-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623281", "l": "FOXO1:PPARGC1A,FOXO4 binds PCK1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168638", "l": "Activated IKK phosphorylates I-kappaB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9696274", "l": "RND1 binds GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29180", "l": "a menaquinol + 2 O2 => a menaquinone + 2 H(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004890", "l": "GABA-A receptor activity", "d": ["Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74715", "l": "Autophosphorylation of insulin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65717", "l": "2-oxoglutarate + a primary linear alkyl sulfate ester + O2 => an aldehyde + CO2 + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199299", "l": "AKT phosphorylates FOXO transcription factors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983147", "l": "Release of E3 from polyubiquitinated substrate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53546", "l": "7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8931981", "l": "RUNX1 binds ESR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42829", "l": "2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014467", "l": "RHOG binds effectors at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45056", "l": "deoxynogalonate + O2 = H(+) + H2O + nogalonate", "d": []}, {"i": "EC:1.13.12.22", "l": "\"deoxynogalonate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805638", "l": "KAT6A acetylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-83788", "l": "Binding of TFIIIC to Type 2 promoter (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6790038", "l": "Expression of HSP90B1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40609", "l": "glycerol + H(+) + tetradecanoate => 1-tetradecanoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12778", "l": "2-amino-4-hydroxypteridine + O2 => 2-amino-4,7-dihydroxypteridine + chemical entity", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13848", "l": "dihydroxyfumarate + H(+) <=> 2-hydroxy-3-oxopropanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18659", "l": "3-hydroxypyruvate + H(+) + NADPH => (R)-glycerate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70385", "l": "CoA + H(+) + N-hexadecanoyl-3-oxosphinganine => 3-oxosphinganine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30862", "l": "dITP + H2O <=> dIDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018769", "l": "2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60479", "l": "2 ATP + GTP <=> 3',3',3'-cAAG + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917839", "l": "apo-Transferrin dissociates from the receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32052", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate => adenosine 5'-tetraphosphate + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28130", "l": "baicalin + H2O = baicalein + D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74840", "l": "UDP(in) + UDP-alpha-D-glucuronate(out) => UDP(out) + UDP-alpha-D-glucuronate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22425", "l": "an S-alkyl-L-cysteine + H2O => an alkyl thiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17345", "l": "(S)-methylmalonyl-CoA + H2O = CoA + H(+) + methylmalonate", "d": []}, {"i": "EC:3.1.2.17", "l": "\"(S)-methylmalonyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40093", "l": "26-oxohexacosanoate + H(+) + NADH => 26-hydroxyhexacosanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888589", "l": "Release of GABA at the synapse (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22016", "l": "[glutaredoxin]-dithiol + arsenate + glutathione + H(+) = arsenite + glutathionyl-S-S-[glutaredoxin] + H2O", "d": []}, {"i": "EC:1.20.4.1", "l": "\"arsenate reductase (glutathione/glutaredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64122", "l": "a fatty acid + L-serine => an N-(fatty acyl)-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0098634", "l": "cell-matrix adhesion mediator activity", "d": ["The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the extracellular matrix."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-517674", "l": "p-S158,221-HuR binds mRNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47725", "l": "glutathione => 5-oxo-L-proline + L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33651", "l": "(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602603", "l": "IRAK4 deficiency blocks formation of the MyD88-IRAK4 Myddosome in the TLR5 pathway (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.29", "l": "\"polyporopepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69068", "l": "RFC dissociates after sliding clamp formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23573", "l": "3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + phlorisovalerophenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73855", "l": "5alpha,6beta,17alpha,27-tetrahydroxywithanolide + UDP-alpha-D-glucose = 5alpha,6beta,17alpha-trihydroxywithanolide 27-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41151", "l": "1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13001", "l": "1D-myo-inositol hexakisphosphate + H2O = 1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate", "d": []}, {"i": "EC:3.1.3.72", "l": "\"5-phytase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18262", "l": "H2O + precorrin-5 + S-adenosyl-L-methionine => acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201443", "l": "Type II receptor phosphorylates type I receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58501", "l": "glycine betaine + H(+) + NADH + O2 => glyoxylate + H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034810", "l": "4,5-dihydroxybenzo(a)pyrene dioxygenase activity", "d": ["Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + O2 = 4,5-chrysenedicarboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381727", "l": "RAP1A exchanges GDP for GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33864", "l": "menaquinone-7 + succinate => fumarate + menaquinol-7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018814", "l": "RHOT1 hydrolyzes GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71052", "l": "L-leucine(out) + L-methionine(in) => L-leucine(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32593", "l": "(3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+) => (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45031", "l": "(2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14096", "l": "2-oxoglutarate + L-tryptophan <=> indole-3-pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807585", "l": "BPI binds LPS on the bacterial surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6795667", "l": "MDM2 translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71374", "l": "epitestosterone 17-sulfate(out) + 2 Na(+)(out) <=> epitestosterone 17-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31481", "l": "H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP => soyasapogenol A + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0009674", "l": "potassium:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Na+(out) = K+(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39100", "l": "3-oxodecanedioyl-CoA + CoA => acetyl-CoA + octanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57097", "l": "AH2 + S-methyl-1-thio-D-xylulose 5-phosphate => 1-deoxy-D-xylulose 5-phosphate + A + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56716", "l": "H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] = H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9620456", "l": "sGC stimulators bind sGC:NO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780979", "l": "CCS transfers Cu to SOD1 (mitochondrial) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419166", "l": "GEFs activate RhoA,B,C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38588", "l": "UDP-alpha-D-glucose + vancomycin aglycone => devancoaminyl-vancomycin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37525", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23331", "l": "a 9-cis-epoxycarotenoid + O2 <=> 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39194", "l": "(2E)-docosenoyl-CoA + H(+) + NADPH <=> docosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6802973", "l": "PLK3 phosphorylates CDC25C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-532549", "l": "MPI isomerises Fru6P to Man6P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015426", "l": "ATPase-coupled polar amino acid-transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40565", "l": "dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+) => dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900748", "l": "NOTCH1 HD+PEST domain mutants bind DLL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0031763", "l": "galanin receptor binding", "d": ["Binding to a galanin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40837", "l": "2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58491", "l": "4-(trimethylamino)butanoate + H(+) + NADH + O2 <=> H2O + NAD(+) + succinate semialdehyde + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0140794", "l": "histone arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone 3 L-arginyl = histone 3 L-citrullyl + NH4+, resulting in histone citrullination."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5252001", "l": "ATP1B4 binds SNW1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38815", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687079", "l": "IGF2BP1 binds MAPK4 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74852", "l": "acetaldehyde + dopamine => (R)-salsolinol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49816", "l": "3 Fe(III)-[cytochrome c] + H2O + hydrazine = 3 Fe(II)-[cytochrome c] + 2 H(+) + NH4(+) + nitric oxide", "d": []}, {"i": "EC:1.7.2.7", "l": "\"hydrazine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71330", "l": "chloride(out) + L-threonine(out) + 2 Na(+)(out) <=> chloride(in) + L-threonine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38653", "l": "(9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10790", "l": "6-phospho-2-dehydro-D-gluconate + ADP + H(+) => 2-dehydro-D-gluconate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64093", "l": "3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 => 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-573297", "l": "TRAF6 binding to IRAK2 stimulates its oligomerizartion upon TLR7 or TLR21 stimulation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706356", "l": "CBL mutants don't ubiquitinate FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030624", "l": "U6atac snRNA binding", "d": ["Binding to a U6atac small nuclear RNA (U6atac snRNA)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031927", "l": "pyridoxamine transmembrane transporter activity", "d": ["Enables the transfer of pyridoxamine from one side of a membrane to the other. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426355", "l": "NTN4 binds laminins with gamma-1, gamma-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32999", "l": "(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.114", "l": "\"amorpha-4,11-diene 12 monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17863", "l": "20-hydroxy-3-oxopregn-4-en-21-al => 21-hydroxyprogesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39146", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39451", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA = (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27486", "l": "allantoate + 2 H(+) + H2O => (S)-2-ureidoglycine + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29127", "l": "a menaquinol + nitrate = a menaquinone + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12188", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2", "d": []}, {"i": "EC:1.2.4.2", "l": "\"oxoglutarate dehydrogenase (succinyl-transferring)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37496", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53066", "l": "2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-methoxyestrone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50797", "l": "glutathione + prostaglandin A2 => prostaglandin A2-S-(R)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32156", "l": "7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine => adenine + epoxyqueuosine(34) in tRNA + 2 H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36781", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate => 2-oxoglutarate + GDP-alpha-D-perosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928591", "l": "EPH:EFN tetramers oligomerise (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322427", "l": "Beta-catenin recruits CBP/p300 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614933", "l": "ACEIs bind ACE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73677", "l": "ADP(in) + dAMP(out) + H(+)(in) => ADP(out) + dAMP(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40019", "l": "ent-copalyl diphosphate + H2O = (-)-ent-copalol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938930", "l": "RUNX1 binds ELF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55788", "l": "acetone + H(+) + NADH + O2 = H2O + hydroxyacetone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49628", "l": "acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine = 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432909", "l": "Interaction of Plectin with Integrin beta 4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38112", "l": "glycerol + NADP(+) => H(+) + L-glyceraldehyde + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65161", "l": "benzoyl-CoA + hexan-2-ol => CoA + hexan-2-yl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399977", "l": "AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42112", "l": "(20S)-hydroxypregn-4-en-3-one + NADP(+) = H(+) + NADPH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61552", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850786", "l": "SPINK6 binds KLK12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114254", "l": "CYCS binds to APAF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9815510", "l": "MIB2 binds CYLD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49128", "l": "AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.326", "l": "\"N-acetyl-demethylphosphinothricin P-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8870469", "l": "RGGT geranylgeranylates RAB proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015398", "l": "high-affinity secondary active ammonium transmembrane transporter activity", "d": ["Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5620975", "l": "MLKL binds PIPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33810", "l": "(E)-ferulate + H(+) <=> 2-methoxy-4-vinylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70983", "l": "glycine(out) + n H(+)(in) = glycine(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77077", "l": "Capping complex formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730835", "l": "Autophosphorylation of PKC-theta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48534", "l": "ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate => ganglioside GQ1c (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952419", "l": "SMURFs ubiquitinate RUNX3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061667", "l": "URM1 ligase activity", "d": ["Catalysis of the transfer of URM1 to a substrate protein via the reaction X-URM1 + S = X + S-URM1, where X is either an E2 or E3 enzyme, the X-URM1 linkage is a thioester bond, and the S-URM1 linkage is an isopeptide bond between the C-terminal amino acid of URM1 and the epsilon-amino group of lysine residues in the substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.18.-", "l": "\"With another compound as one donor, and incorporation of one atom of oxygen\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61524", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38546", "l": "H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] <=> (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.114", "l": "\"polyprenyldihydroxybenzoate methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59390", "l": "a fatty acid + an aliphatic alcohol + H(+) => a fatty acid ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34720", "l": "15-methylhexadecasphing-4-enine 1-phosphate => (2E)-13-methyltetradecenal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38594", "l": "devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine <=> chloroorienticin B + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183051", "l": "CBL ubiquitinates Sprouty (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174235", "l": "Association of Emi1 with Cdc20 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610723", "l": "GLI proteins bind SUFU (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65503", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016212", "l": "kynurenine-oxoglutarate transaminase activity", "d": ["Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68164", "l": "N-(8'-hydroxygeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + N-(8'-oxogeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203130", "l": "OLR1 binds to oxidized LDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64329", "l": "(7Z)-octadecenoyl-CoA + cholesterol => cholesteryl (7Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72696", "l": "UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) => UDP-N-acetyl-alpha-D-glucosamine(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213241", "l": "Formation of nonameric complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.5", "l": "\"dextransucrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29099", "l": "a menaquinone + 5 H(+)(in) + NADH = a menaquinol + 4 H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050391", "l": "valine dehydrogenase (NADP) activity", "d": ["Catalysis of the reaction: L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013963", "l": "RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852337", "l": "GTSE1 binds TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8985943", "l": "p-Y701-STAT1 dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-449117", "l": "TXLNA (IL14) binds syntaxin1A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964759", "l": "Alternative endo-mannosidase I route (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72874", "l": "anthocyanin A3 + malonyl-CoA <=> anthocyanin A5 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47097", "l": "(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate => (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022841", "l": "potassium ion leak channel activity", "d": ["Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690493", "l": "RHOB binds effectors on endosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047368", "l": "UDP-N-acetylgalactosamine-4-sulfate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + UDP-N-acetyl-D-galactosamine 4-sulfate = adenosine 3',5'-diphosphate + H+ + UDP-N-acetyl-D-galactosamine 4,6-disulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672957", "l": "PP2A dephosphorylates KSR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57203", "l": "glyoxal + L-arginyl-[protein] <=> N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36500", "l": "2-dehydro-3-deoxy-L-rhamnonate + NAD(+) => 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451377", "l": "Interaction of IQGAP1 with nephrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018824", "l": "(hydroxyamino)benzene mutase activity", "d": ["Catalysis of the reaction: (hydroxyamino)benzene = 2-aminophenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632924", "l": "TP53 stimulates GLS2 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23981", "l": "cyclomaltodextrin + H2O => linear maltodextrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036132", "l": "13-prostaglandin reductase activity", "d": ["Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044668", "l": "sodium:malonate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ malonate(out) = sodium(in) + malonate(in)."]}, {"i": "RHEA:33135", "l": "malonate(in) + Na(+)(in) = malonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60131", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O <=> 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183126", "l": "Factor B binds to surface-associated C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948066", "l": "K63polyUb-IRAK1 dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674531", "l": "AAMP binds EGFR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688786", "l": "ATXN3 binds RAD23 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67359", "l": "(2S)-naringenin 7-O-beta-D-glucoside + malonyl-CoA <=> (2S)-naringenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62342", "l": "(+)-malbrancheamide C + FADH2 => (+)-premalbrancheamide + bromide + FAD + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42079", "l": "2-hydroxyglutarate + acetyl-CoA <=> 2-hydroxyglutaryl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48933", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b => CMP + ganglioside GQ1b + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933530", "l": "Activation of IKK by MEKK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187828", "l": "Translocation of p21 to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55702", "l": "an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate => an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74715", "l": "Autophosphorylation of insulin receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38999", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047849", "l": "dextransucrase activity", "d": ["Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = D-fructose + 1,6-alpha-D-glucosyl(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73778", "l": "dimethylallyl diphosphate + preechinulin <=> diphosphate + tardioxopiperazine B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53470", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75151", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = diphosphate + neoverrucosan-5beta-ol", "d": []}, {"i": "EC:4.2.3.207", "l": "\"neoverrucosan-5beta-ol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0005234", "l": "extracellularly glutamate-gated ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11452", "l": "7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794008", "l": "LUBAC binds CFLAR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.29", "l": "\"pyranose dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11337", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine => deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25973", "l": "H2O + N(8)-acetylspermidine + O2 => 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58440", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47211", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9648017", "l": "EML4 binds to microtubules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036021", "l": "Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)6 (PP-Dol)1 by ALG9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433415", "l": "Activation of RAC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54956", "l": "ATP + CoA + OPC-6 = AMP + diphosphate + OPC-6-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51872", "l": "dimethylallyl diphosphate + umbelliferone = diphosphate + osthenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625210", "l": "Defective SLC22A12 does not exchange extracellular urate for cytosolic LACT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74150", "l": "(S)-2-benzoylsuccinyl-CoA + CoA <=> benzoyl-CoA + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3318415", "l": "ATF2 acetylates histone H2B, H4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1237160", "l": "MTA is cleaved and phosphorylated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40751", "l": "(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate = 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404142", "l": "atROL binds RBP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193643", "l": "PRDM4 (SC1) binds to p75NTR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013990", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427404", "l": "Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34694", "l": "(R)-lactoyl-CoA <=> acryloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44393", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA => 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098614", "l": "hydrogen selenide methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + hydrogen selenide => S-adenosyl-L-homocysteine + methaneselenol."]}, {"i": "REACT:R-HSA-2408536", "l": "H2Se is methylated to MeSeH by H2Se methyltransferase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28645", "l": "alpha-zingiberene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3899291", "l": "SUMOylation of EP300 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62583", "l": "ATP + D-cystine(out) + H2O <=> ADP + D-cystine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66931", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O <=> a (N(7)-methyl 5'-triphospho-guanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27412", "l": "3 a menaquinone + protoporphyrinogen IX <=> 3 a menaquinol + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45333", "l": "7,8-dihydroneopterin + O2 => 7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44945", "l": "1-O-alkyl-3-acyl-sn-glycerol + H2O => 1-O-alkyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.25", "l": "\"gellan lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48508", "l": "cholate + NADP(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985943", "l": "p-Y701-STAT1 dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20692", "l": "chlorogenate + H2O <=> (E)-caffeate + H(+) + L-quinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22333", "l": "(3R)-citramalate => 2-methylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008603", "l": "cAMP-dependent protein kinase regulator activity", "d": ["Modulation of the activity of the enzyme cAMP-dependent protein kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18068", "l": "ATP + H2O + phosphonate(out) <=> ADP + H(+) + phosphate + phosphonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49108", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine = 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626699", "l": "MARK4 binds ODF2 in the centriole (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64226", "l": "5-hydroxyuridine(34) in tRNA + A + H2O => AH2 + O2 + uridine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866851", "l": "CFTR transits to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047269", "l": "poly(ribitol-phosphate) N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: poly(ribitol phosphate) + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-poly(ribitol phosphate) + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64111", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031894", "l": "V1A vasopressin receptor binding", "d": ["Binding to a V1A vasopressin receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061849", "l": "telomeric G-quadruplex DNA binding", "d": ["Binding to telomeric G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures in telomeres."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205262", "l": "Direct recruitment of PI3K to p-KIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109701", "l": "PDPK1 binds PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47519", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isochenodeoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11776", "l": "2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.2", "l": "\"stearoyl-[acyl-carrier-protein] 9-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26248", "l": "geranylgeranyl diphosphate <=> diphosphate + fusicocca-2,10(14)-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004413", "l": "homoserine kinase activity", "d": ["Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201622", "l": "Caspase-mediated cleavage of gelsolin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174097", "l": "Association of Emi1 with Cdh1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450325", "l": "c-FOS activation by phospho ERK1/2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008987", "l": "quinolinate synthetase A activity", "d": ["Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64437", "l": "glycylglycyl-L-isoleucine(out) + H(+)(out) => glycylglycyl-L-isoleucine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864999", "l": "TGFA gene expression is stimulated by the TFAP2A homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22699", "l": "AH2 + androst-4-ene-3,17-dione + O2 <=> A + H2O + testololactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013108", "l": "GDIs block activation of RHOC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11583", "l": "a CDP-1,2-diacyl-sn-glycerol + myo-inositol <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20474", "l": "(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] => (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43511", "l": "2,5-diformylfuran + H2O <=> 2-(dihydroxymethyl)-5-formylfuran", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55568", "l": "4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine = 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.345", "l": "\"psilocybin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36287", "l": "H(+) + NADPH + O2 + theobromine = 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41691", "l": "1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.40", "l": "\"bleomycin hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70584", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74189", "l": "H(+) + S-adenosyl-L-homocysteine + taxifolin 3'-methyl ether => S-adenosyl-L-methionine + taxifolin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55751", "l": "coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22679", "l": "chlorophyllide a + H(+) + NADPH + O2 <=> 7(1)-hydroxychlorophyllide a + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700171", "l": "Active ALK phosphorylates PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47350", "l": "an aliphatic alcohol + butanoate + H(+) => a butanoate ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68489", "l": "(2R)-2-hydroperoxytetradecanoate + H(+) => CO2 + H2O + tridecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17684", "l": "3-hydroxy-2-methylpropanoate + NAD(+) <=> 2-methyl-3-oxopropanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432054", "l": "Aquaporin-1 passively transports water out of cell (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75624", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate => 14-oxo-15-hydroxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607737", "l": "BCL10 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74292", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate => an alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70577", "l": "H(+) + UMP => 3',5'-cyclic UMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626817", "l": "PKC phosphorylates NCF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65167", "l": "benzoyl-CoA + hexan-3-ol <=> CoA + hexan-3-yl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65847", "l": "ADP(out) + H(+)(out) + phosphate(in) <=> ADP(in) + H(+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33900", "l": "FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose => FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015367", "l": "oxoglutarate:malate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013108", "l": "GDIs block activation of RHOC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74176", "l": "a secondary alkyl amine + H2O + NAD(+) => a ketone + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5229283", "l": "LCNs bind lipids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32361", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+) => 1D-myo-inositol 1,4,5-trisphosphate + 2 ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004131", "l": "cytosine deaminase activity", "d": ["Catalysis of the reaction: cytosine + H2O = uracil + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177942", "l": "EGFR binds EGF ligand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20698", "l": "H2O2 + O2 => 2 H(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419465", "l": "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31135", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate = 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22233", "l": "H(+) + NADPH + presqualene diphosphate => diphosphate + NADP(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449058", "l": "Interleukin-1 family are secreted (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37342", "l": "3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O <=> (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928644", "l": "EPHB binds ITSN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62301", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434836", "l": "Syk/Lck phosphorylate LAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27929", "l": "UMP(in) <=> UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.10.1.-", "l": "\"Acting on sulfur-nitrogen bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140862", "l": "histone H2AK119 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-119 residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68586", "l": "ADP + H(+) + L-tryptophan(in) + phosphate => ATP + H2O + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54456", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68482", "l": "CO2 + H2O + pentadecanal => (2R)-2-hydroperoxyhexadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18832", "l": "4-phospho-D-erythronate + NAD(+) <=> (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420128", "l": "SRC-1 phosphorylates SHB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64690", "l": "3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34920", "l": "thiamine(in) => thiamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977375", "l": "CR1 binds C3bBb/C4bC2a (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23594", "l": "D-glyceraldehyde + H(+) + NADPH => glycerol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66444", "l": "hexan-3-one + NADP(+) = (E)-4-hexen-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22590", "l": "1-pyrroline + H2O => 4-aminobutanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62637", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide => (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111237", "l": "Formation of ADAR1 homodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15168", "l": "H2O + O2 + sarcosine <=> glyoxylate + H2O2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20407", "l": "(2S,6S)-2,6-diaminoheptanedioate + acetate => H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "58.369810610503507", "identifiers": [{"i": "GO:0016741", "l": "transferase activity, transferring one-carbon groups", "d": ["Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.1.-.-", "l": "\"Transferring one-carbon groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201669", "l": "Beta-catenin translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26527", "l": "a (3R)-3-hydroxyacyl-CoA => a (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62688", "l": "4 norrubrofusarin + O2 = 2 H2O + 2 ustilaginoidin A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0017070", "l": "U6 snRNA binding", "d": ["Binding to a U6 small nuclear RNA (U6 snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912357", "l": "ITCH ubiquitinates DTX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36115", "l": "gibberellin A3 + S-adenosyl-L-methionine = O-methyl gibberellin A3 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097257", "l": "leukotriene B4 12-hydroxy dehydrogenase activity", "d": ["Catalysis of the reaction: leukotriene B4 + NADP+ = 12-oxo-leukotriene B4 + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61507", "l": "pelargonidin + UDP-alpha-D-glucose <=> pelargonidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16177", "l": "H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2106625", "l": "Duplex siRNA is loaded into Argonaute (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203716", "l": "eNOS:Caveolin-1 complex binds to Nostrin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36992", "l": "phosphate + UMP => alpha-D-ribose 1,5-bisphosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54359", "l": "3-methyl-2-oxobutanoate + H(+) <=> 2-methylpropanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15360", "l": "5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose <=> demethyllactenocin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50356", "l": "4-hydroxy-6-methylpretetramide + NADPH + O2 = 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.233", "l": "\"4-hydroxy-6-methylpretetramide 12a-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38433", "l": "(9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+) => 1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801101", "l": "RABGGTA binds RABGGTB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75998", "l": "3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) <=> 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700656", "l": "alectinib resistant ALK mutants don't bind alectinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74650", "l": "GTP + N-acetyl-D-glucosamine <=> GDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5226999", "l": "ADD1:ADD3 binds DMTN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16965", "l": "(2E)-geranyl diphosphate = beta-myrcene + diphosphate", "d": []}, {"i": "EC:4.2.3.15", "l": "\"myrcene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21762", "l": "(3R)-3-hydroxybutanoyl-CoA => (3S)-3-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951676", "l": "RUNX3 binds TEADs and YAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43026", "l": "2-aminoprop-2-enoate + a thiol => an S-substituted L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863973", "l": "Fusion of ERC and phagosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0015067", "l": "amidinotransferase activity", "d": ["Catalysis of the reversible transfer of an amidino group to an acceptor."]}, {"i": "EC:2.1.4.-", "l": "\"Amidinotransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799761", "l": "TP53 binds PPP1R13L (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604763", "l": "Autocatalytic activation of MMP7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68427", "l": "(3R)-3-hydroxy-10'-apo-beta-carotenal + O2 <=> (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54985", "l": "a ubiquinol => a ubiquinone + 2 e(-) + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71981", "l": "diphosphate + fusoxypene A => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793666", "l": "MDM2 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33336", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O => 1,2-dioctadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2769015", "l": "NICD1 PEST domain mutants translocate from cytosol to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418091", "l": "F2R binds ARRB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50269", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55708", "l": "[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide", "d": []}, {"i": "EC:2.4.2.60", "l": "\"cysteine-dependent adenosine diphosphate thiazole synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26004", "l": "D-xylulose 5-phosphate + H(+) + NADH => D-arabinitol 1-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688797", "l": "ATXN3 family cleave Ub chains (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43871", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in) <=> a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391913", "l": "FPR2 binds FPR2 ligands (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170120", "l": "Translocation of Cdc25B to the cytoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5336184", "l": "GPR37L binds prosaposin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810724", "l": "PI3 binds the bacterial surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033201", "l": "alpha-1,4-glucan synthase activity", "d": ["Catalysis of the reaction: RDP-glucose + [alpha-D-glucosyl-(1,4)]n = RDP + [alpha-D-glucosyl-(1,4)]n+1, where RDP is ADP or UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70187", "l": "alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose = cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.8", "l": "\"T4 deoxyribonuclease II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49782", "l": "CoA + H(+) + N-docosanoylglycine => docosanoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168923", "l": "Collagen type XVIII endostatin release (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034578", "l": "limonene 8-hydratase activity", "d": ["Catalysis of the reaction: limonene + H2O = alpha-terpineol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1297444", "l": "Binding of cAMP to HCN channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54711", "l": "N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671737", "l": "p-T774-PKN1 binds CDC25C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30141", "l": "CoA + H(+) + octadecanoate => H2O + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938987", "l": "BLK gene expression is stimulated by the complex of RUNX1 and ELF1, ELF2 or PAX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20608", "l": "cytosine + H(+) + H2O <=> NH4(+) + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44128", "l": "(9E)-octadecenoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl (9E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72413", "l": "alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O => inulobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21086", "l": "dermatan 4'-sulfate => chondroitin 4'-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181155", "l": "The NODAL Receptor binds NODAL ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794354", "l": "NMDA receptor complex:DLG2,DLG3,DLG4:SPAR binds PDLIM5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013004", "l": "RHOA binds effectors at the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26550", "l": "(S)-piperazine-2-carboxamide + H2O = (S)-piperazine-2-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50711", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione <=> (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.51", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58035", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149519", "l": "MMACHC decyanates CNCbl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198756", "l": "ERK1/2 phosphorylates MSK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654425", "l": "Activated FGFR4 binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48641", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) => 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578712", "l": "Importin-8 binds AGO2:miRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16988", "l": "3-oxoadipate + NADP(+) <=> H(+) + maleylacetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34584", "l": "2-oxoglutarate + O2 + pentalenolactone D => CO2 + H2O + pentalenolactone E + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15118", "l": "3'-dephospho-CoA + ATP => 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27591", "l": "(R)-pantoate + ATP + beta-alanine => (R)-pantothenate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23601", "l": "2-oxoglutarate + L-2-aminohexanoate => 2-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36638", "l": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26124", "l": "FAD + L-proline = (S)-1-pyrroline-5-carboxylate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689630", "l": "BAP1 binds BAP1-interacting complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31281", "l": "(2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate => (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55896", "l": "chloride + FADH2 + L-tryptophan + O2 = 5-chloro-L-tryptophan + FAD + 2 H2O", "d": []}, {"i": "EC:1.14.19.58", "l": "\"tryptophan 5-halogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694527", "l": "Loss of SAR1B GTPase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58424", "l": "(E)-hex-2-en-1-ol + NADP(+) = (E)-hex-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16021", "l": "oxaloacetate = enol-oxaloacetate", "d": []}, {"i": "EC:5.3.2.2", "l": "\"oxaloacetate tautomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003875", "l": "ADP-ribosylarginine hydrolase activity", "d": ["Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005980", "l": "IL21 binds IL21R:JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10164", "l": "(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate", "d": []}, {"i": "EC:4.2.1.11", "l": "\"phosphopyruvate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52600", "l": "L-methionine + propanoyl-CoA = CoA + H(+) + N-propanoyl-L-methioninate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20567", "l": "(1S,2S,4R)-endo-fenchol + diphosphate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12943", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657051", "l": "OGG1beta G12E does not translocate to mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50082", "l": "ADP + H(+) + phosphate + taurodeoxycholate(out) => ATP + H2O + taurodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110219", "l": "Cleavage of thymine by TDG glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848335", "l": "IL37 binds  IL18R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201708", "l": "Frizzled receptors bind Wnts (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21457", "l": "(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204824", "l": "Interaction of Tie2 and Ang4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1638845", "l": "CERK phosphorylates CERA to form C1P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613513", "l": "PLINs:HSPA8 binds PRKAA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139895", "l": "tBID activates BAK protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19194", "l": "A + all-trans-13,14-dihydroretinol => AH2 + all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38790", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140756", "l": "structural constituent of proteasome", "d": ["The action of a molecule that contributes to the structural integrity of the proteasome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57494", "l": "2-methylcitrate + CoA + H(+) => H2O + oxaloacetate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34202", "l": "2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 <=> bracteatin 6-O-beta-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693761", "l": "FA2H hydroxylates CERA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635102", "l": "GPR161 is internalized (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205231", "l": "Dimerization of KIT upon SCF binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41088", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol => 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5632738", "l": "DDIT4 binds 14-3-3 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19237", "l": "4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide", "d": []}, {"i": "EC:5.4.99.14", "l": "\"4-carboxymethyl-4-methylbutenolide mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102766", "l": "naringenin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-naringenin(1-) + S-adenosyl-L-methionine <=> sakuranetin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32358", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose <=> 2 H(+) + ternatin C5 + 2 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24705", "l": "NAD(+) + UDP-alpha-D-glucuronate <=> CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389969", "l": "Beta-tubulin:GTP + Cofactor D ->  Beta-tubulin:GTP: Cofactor D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849055", "l": "PTK6 binds ARHGAP35 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034918", "l": "3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-methylhexanoyl-CoA = 2-methyl-3-oxohexanoyl-CoA + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901359", "l": "tungstate binding", "d": ["Binding to tungstate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30278", "l": "AH2 + H2O2 <=> A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34427", "l": "(-)-lariciresinol + NADP(+) = (-)-pinoresinol + H(+) + NADPH", "d": []}, {"i": "EC:1.23.1.3", "l": "\"(-)-pinoresinol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23124", "l": "2 (2R)-3-phosphoglycerate + 2 H(+) = CO2 + D-ribulose 1,5-bisphosphate + H2O", "d": []}, {"i": "EC:4.1.1.39", "l": "\"ribulose-bisphosphate carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004153", "l": "dihydropterin deaminase activity", "d": ["Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32911", "l": "sn-glycerol 3-phosphocholine(out) = sn-glycerol 3-phosphocholine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70756", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656230", "l": "Defective B4GALT1 does not transfer Gal to the keratan chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0004602", "l": "glutathione peroxidase activity", "d": ["Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75711", "l": "a rhodoquinone + succinate = a rhodoquinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418172", "l": "F2R binds ARRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50057", "l": "ATP + glycocholate(in) + H2O => ADP + glycocholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53798", "l": "deoxycholate + ursodeoxycholoyl-CoA => deoxycholoyl-CoA + ursodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15085", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine", "d": []}, {"i": "EC:3.2.1.49", "l": "\"alpha-N-acetylgalactosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824280", "l": "MSGN1 binds the DLL3 gene in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021050", "l": "HSBP1 oligomer binds ESRs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429101", "l": "HMIT co-transports myo-inositol with a proton (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48327", "l": "ganglioside GD1b + GDP-beta-L-fucose <=> ganglioside Fuc-GD1b + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851011", "l": "TRIM27 polyubiquitinates PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080078", "l": "tricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a tricaffeoyl spermidine molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696822", "l": "AKR1B15 reduces EST17b to E1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64053", "l": "(13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine => CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018505", "l": "Estrogen-responsive EBAG9 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909729", "l": "Activation of JAK kinases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809764", "l": "SBF1 binds MTMR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0001793", "l": "IgM receptor activity", "d": ["Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48438", "l": "an aliphatic alcohol + H(+) + pentanoate => H2O + pentanoate ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72722", "l": "eIF2 activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013023", "l": "RHOB GEFs activate RHOB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047980", "l": "hippurate hydrolase activity", "d": ["Catalysis of the reaction: N-benzoylglycine + H2O = benzoate + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35028", "l": "ATP + H2O + tungstate(in) => ADP + H(+) + phosphate + tungstate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669893", "l": "KIT binds type I TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34967", "l": "sn-glycerol 3-phosphate(in) = sn-glycerol 3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622310", "l": "Activated NOD1 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3234081", "l": "SUMOylation of TFAP2A with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-178208", "l": "SMAD7 binds to SMURF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14693", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = a dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP", "d": []}, {"i": "EC:2.4.1.153", "l": "\"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23216", "l": "benzoyl-CoA + H(+) + NADPH + O2 = 3-hydroxybenzoyl-CoA + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.58", "l": "\"benzoyl-CoA 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371435", "l": "Constitutive phosphorylation by GSK3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928597", "l": "EPH:EFN dimers tetramerise (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20773", "l": "2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) => 5-amino-6-(D-ribitylamino)uracil + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27398", "l": "4'-demethylrebeccamycin + H2O => beta-D-glucose + dichloroarcyriaflavin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73729", "l": "(2S,3R,11R)-aszonalenin + diphosphate => (R)-benzodiazepinedione + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16660", "l": "H2O + inosine <=> D-ribose + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030267", "l": "glyoxylate reductase (NADP+) activity", "d": ["Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168869", "l": "Budding of vesicle with the HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum into the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211959", "l": "CYP3A43 6b-hydroxylates TEST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25752", "l": "N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879674", "l": "CD97 binds CD55 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71352", "l": "androsterone 3alpha-sulfate(out) + 2 Na(+)(out) => androsterone 3alpha-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72663", "l": "De novo formation of eIF2:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24793", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate", "d": []}, {"i": "EC:4.3.2.10", "l": "\"imidazole glycerol-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33722", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71859", "l": "glycochenodeoxycholate(out) = glycochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11003", "l": "an N-carbamoyl-D-amino acid + 2 H(+) + H2O <=> a D-alpha-amino acid + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69286", "l": "a 17-oxo steroid + H(+) + NADPH => a 17beta-hydroxy steroid + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11872", "l": "corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": []}, {"i": "EC:1.14.15.5", "l": "\"corticosterone 18-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19369", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine = H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.85", "l": "\"protein-histidine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34870", "l": "ATP + CoA + thiophene-2-carboxylate <=> AMP + diphosphate + thiophene-2-carbonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29044", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH => (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75568", "l": "acetyl-CoA + cyathatriol => 11-O-acetylcyathatriol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201515", "l": "Active ALK recruits PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030341", "l": "chondroitin AC lyase activity", "d": ["Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684234", "l": "Encapsidation of SARS coronavirus genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16746", "l": "AH2 + O2 + phylloquinone => 2,3-epoxyphylloquinone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627891", "l": "Defective SLC27A4 does not transport LCFAs from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58132", "l": "A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] = AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665727", "l": "FMNL2 binds CDC42:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390649", "l": "CHRM1,3,5 bind acetylcholine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36506", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA <=> (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28954", "l": "H(+)(in) + L-arabinose(in) <=> H(+)(out) + L-arabinose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54520", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = cycloaraneosene + diphosphate", "d": []}, {"i": "EC:4.2.3.191", "l": "\"cycloaraneosene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33399", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) = L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)", "d": []}, {"i": "EC:2.7.1.192", "l": "\"protein-N(pi)-phosphohistidine--N-acetylmuramate phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18287", "l": "a carboxylate + D-aspartate => an N-acyl-D-aspartate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12998", "l": "(E)-feruloyl-CoA + galactarate => 2-O-[(E)-feruloyl]-D-galactarate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46725", "l": "(2S)-2-methyltetradecanoyl-CoA => (2R)-2-methyltetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15899", "l": "4-aminobutanoate + acetate => 4-acetamidobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19347", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625548", "l": "Hypochlorous acid (HOCL) oxidizes Cys residues to form Cys-sulfenyl chloride (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66916", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25913", "l": "A + H2O + quinolin-5-ol => 5-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34287", "l": "2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354097", "l": "Activation of Talin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30895", "l": "H2O + O2 + propane-1,3-diamine = 3-aminopropanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31058", "l": "estrone 3-sulfate + H2O <=> estrone + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75066", "l": "chloride(out) + 2 hydrogencarbonate(in) + Li(+)(in) <=> chloride(in) + 2 hydrogencarbonate(out) + Li(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37180", "l": "(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate => (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75872", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374173", "l": "AGT(34-41) binds to AGTR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008922", "l": "long-chain fatty acid [acyl-carrier-protein] ligase activity", "d": ["Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668831", "l": "CST complex formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607737", "l": "BCL10 oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31306", "l": "a reduced flavin + NAD(+) <=> an oxidized flavin + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66559", "l": "dopamine + L-glutaminyl-[protein] <=> 5-dopaminyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37882", "l": "methyl aklanonate <=> aklaviketone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34097", "l": "CO2 + spermidine => carboxyspermidine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38246", "l": "(9Z)-octadecenoyl-CoA + eicosan-1-ol <=> 1-O-eicosanyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193684", "l": "p62 recruits an atypical PKC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74220", "l": "H2O + L-seryl-tRNA(Thr) => L-serine + tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.2", "l": "\"ribonuclease alpha\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047536", "l": "2-aminoadipate transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66672", "l": "4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) = 5,7-dihydroxy-4-methylphthalide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15475", "l": "flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP => flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653596", "l": "Defective SLC35C1 does not transport UDP-Fuc from cytosol to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71664", "l": "a menaquinone + 2 H(+)(out) + succinate => a menaquinol + fumarate + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640063", "l": "Ca2+ binds KCNIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-976768", "l": "Factor H binds to C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23284", "l": "isopentenyl diphosphate = dimethylallyl diphosphate", "d": []}, {"i": "EC:5.3.3.2", "l": "\"isopentenyl-diphosphate Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42567", "l": "uridine(38/39) in tRNA <=> pseudouridine(38/39) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11458", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29266", "l": "L-leucine(in) + Na(+)(in) <=> L-leucine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483174", "l": "PE is methylated to PC by PEMT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399939", "l": "Autophosphorylation of PAK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28024", "l": "AMP + diphosphate + octanoyl-[ACP] => ATP + holo-[ACP] + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0004517", "l": "nitric-oxide synthase activity", "d": ["Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160931", "l": "Disassembly of tight junctions (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45977", "l": "3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050643", "l": "10-deacetylbaccatin III 10-O-acetyltransferase activity", "d": ["Catalysis of the reaction: 10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69767", "l": "(E)-non-2-enal + H2O + NAD(+) = (E)-non-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39335", "l": "3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427514", "l": "eNoSC deacetylates histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944227", "l": "Association of procollagen type XXII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008157", "l": "protein phosphatase 1 binding", "d": ["Binding to a protein phosphatase 1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853792", "l": "RET tyrosine phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653514", "l": "USP17L2 deubiquitinates RCE1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981926", "l": "RAC1 and CDC42 activate PAK3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690669", "l": "CD22 binds itself to form homo-oligomers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047982", "l": "homocysteine desulfhydrase activity", "d": ["Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75123", "l": "(1R)-(1-hydroxyethyl)phosphonate + O2 = acetate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44657", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854052", "l": "Formation of the SCF-FBXL7 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810376", "l": "ING2 binds PI5P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23079", "l": "4-chlorobenzoyl-CoA + chloride + NADP(+) <=> 2,4-dichlorobenzoyl-CoA + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69759", "l": "H2O + NAD(+) + nonanal = 2 H(+) + NADH + nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29848", "l": "(2E)-tetradecenoyl-CoA => (3Z)-tetradecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56466", "l": "1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811412", "l": "Active ARF recruits coatomer to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051719", "l": "DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpN = S-adenosyl-L-homocysteine + DNA containing 5-MeCpN."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47069", "l": "4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140161", "l": "monocarboxylate:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monocarboxylate(out) + Na+(out) = monocarboxylate(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62294", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2 => (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5138459", "l": "WNT5A:FZD4 is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39183", "l": "3-oxodocosanoyl-CoA + H(+) + NADPH = (3R)-hydroxydocosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813626", "l": "LEAP2 binds bacteria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59708", "l": "D-maltotriono-1,5-lactone + H2O = D-maltotrionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42361", "l": "D-allulose => keto-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654514", "l": "KAL1 binds FGFR1c (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53566", "l": "18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781899", "l": "USP13 binds SIAH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013147", "l": "RAC1 GDIs block activation of RAC1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166168", "l": "TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56150", "l": "CoA + hexadecanoyl-sn-glycero-3-phosphocholine => hexadecanoyl-CoA + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36731", "l": "1-nitrocyclohexan + NADP(+) = 1-nitrocyclohexene + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030628", "l": "pre-mRNA 3'-splice site binding", "d": ["Binding to a pre-mRNA 3' splice site sequence."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19059", "l": "a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O => a hydroperoxy polyunsaturated fatty acid + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733969", "l": "Bile salts dissociate from FABP6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31613", "l": "H2O + rhodopin => 1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70906", "l": "(2R)-3-phospho-glyceroyl phosphate + 2-deoxy-alpha-D-ribose 1-phosphate <=> (2R)-3-phosphoglycerate + 2-deoxy-alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661517", "l": "LUBAC binds OTULIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873927", "l": "Release of STAT1 dimer from active receptor unit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67708", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48566", "l": "D-ribose 5-phosphate + trans-zeatin => 9-ribosyl-trans-zeatin 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031766", "l": "type 3 galanin receptor binding", "d": ["Binding to a type 3 galanin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62106", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620197", "l": "HSPA8:Substrate binds LAMP2a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68067", "l": "a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55535", "l": "H(+) + H2O + L-phenylalanine + O2 <=> 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015527", "l": "glycerol-phosphate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerol phosphate(out) + inorganic phosphate(in) = glycerol phosphate(in) + inorganic phosphate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24323", "l": "an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32261", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde => beta-D-fructose 1-phosphate + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57682", "l": "a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => a flavanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61864", "l": "AH2 + dehydroprobetaenone I = A + probetaenone I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938853", "l": "CDK6 binds RUNX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66591", "l": "a cytidine in 26S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53951", "l": "ATP + holo-[BtrI ACP] + L-glutamate <=> ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46879", "l": "[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate <=> [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24696", "l": "(E)-coniferyl acetate + NADPH => (E)-isoeugenol + acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0004511", "l": "tyrosine 3-monooxygenase activity", "d": ["Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6794346", "l": "NRXNs bind NLGNs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61565", "l": "a tetracycline + H(+) + NADPH + O2 => a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2173317", "l": "C3a anaphylatoxin binds C3a receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74837", "l": "UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-galactosamine(out) => UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-galactosamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55135", "l": "ATP + D-alanine + holo-[D-alanyl-carrier protein] <=> AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55715", "l": "(S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937419", "l": "CBR3 reduces DOX to DOXOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38757", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15021", "l": "(E)-feruloyl-CoA + L-quinate = 4-O-feruloyl-D-quinate + CoA", "d": []}, {"i": "EC:2.3.1.99", "l": "\"quinate O-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27402", "l": "2-hydroxychromene-2-carboxylate => (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-919404", "l": "Phosphorylated STAT5 is released (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57701", "l": "a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69103", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53224", "l": "16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43628", "l": "L-serine + NAD(+) = aminoacetaldehyde + CO2 + NADH", "d": []}, {"i": "EC:1.1.1.387", "l": "\"L-serine 3-dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67320", "l": "(2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate = sch 210971", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59487", "l": "arsenite + 2 Fe(III)-[cytochrome c] + H2O <=> arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052605", "l": "gamma-tocopherol cyclase activity", "d": ["Catalysis of the reaction: 2,3-dimethyl-6-phytyl-1,4-benzoquinone = gamma-tocopherol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74353", "l": "2 (S)-lactate(out) + prostaglandin E3(in) => 2 (S)-lactate(in) + prostaglandin E3(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45037", "l": "3 Fe(III)-[cytochrome c] + hydroxylamine => 3 Fe(II)-[cytochrome c] + 3 H(+) + nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102275", "l": "cysteine-S-conjugate N-malonyl transferase activity", "d": ["Catalysis of the reaction: malonyl-CoA(5-) + an L-cysteine-S-conjugate <=> coenzyme A + H+ + an N-malonyl-L-cysteine-S-conjugate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61987", "l": "H(+) + NADH + ubiquinone-10 <=> NAD(+) + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674019", "l": "BRAP binds KSR1:MARK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26313", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = dihydroxyacetone phosphate + L-aspartate 4-semialdehyde", "d": []}, {"i": "EC:4.1.2.56", "l": "\"2-amino-4,5-dihydroxy-6-oxo-7-(phosphonooxy)heptanoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73945", "l": "FAS-mediated dimerization of procaspase-8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229343", "l": "AXIN is phosphorylated in the destruction complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65772", "l": "2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36959", "l": "D-ribono-1,4-lactone + H(+) + NADH = D-ribose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13338", "l": "D-glucurono-6,2-lactone + H2O => D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75244", "l": "FASL binds FAS Receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58341", "l": "beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O => chenodeoxycholate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49043", "l": "(-)-5'-demethylyatein + S-adenosyl-L-methionine <=> (-)-yatein + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14239", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine => 10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507870", "l": "Aquaporins passively transport water out of cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604763", "l": "Autocatalytic activation of MMP7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14002", "l": "choloyl-CoA + glycine => CoA + glycocholate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11400", "l": "GDP-6-deoxy-alpha-D-altrose + sordaricin = 4'-O-demethylsordarin + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.353", "l": "\"sordaricin 6-deoxyaltrosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848436", "l": "PTK6 phosphorylates CDKN1B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64324", "l": "(11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.38", "l": "\"plasmepsin I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689630", "l": "BAP1 binds BAP1-interacting complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786421", "l": "CHIA hydrolyses chitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10842", "l": "L-threonine + phosphate => H2O + O-phospho-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65800", "l": "a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O = a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112037", "l": "Inactivation of PLC beta (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74480", "l": "(-)-cyclopeptine + 2-oxoglutarate + O2 => (Z)-dehydrocyclopeptine + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.106", "l": "\"fatty acid photodecarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22640", "l": "NADP(+) + sphinganine = 3-oxosphinganine + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.102", "l": "\"3-dehydrosphinganine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39871", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102428", "l": "kaempferol-3-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-alpha-D-glucose <=> kaempferol-3-gentiobioside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23784", "l": "a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28394", "l": "L-alanyl-L-glutamate = L-alanyl-D-glutamate", "d": []}, {"i": "EC:5.1.1.20", "l": "\"L-Ala-D/L-Glu epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3095889", "l": "MMACHC dealkylates RCbl (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70506", "l": "H2O + isopentenyl diphosphate <=> H(+) + isopentenyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31674", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66863", "l": "dimethylallyl diphosphate + 4 isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031689", "l": "A3 adenosine receptor binding", "d": ["Binding to an A3 adenosine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40546", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2106625", "l": "Duplex siRNA is loaded into Argonaute (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37575", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033891", "l": "CC-preferring endodeoxyribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage to give 5'-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0008253", "l": "5'-nucleotidase activity", "d": ["Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102365", "l": "taxusin 2-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: taxusin + NADPH + O2 + H+ = 2-alpha-hydroxytaxusin + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65962", "l": "ADP + H(+) + leukotriene C4(in) + phosphate => ATP + H2O + leukotriene C4(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20119", "l": "ADP + H(+) + L-rhamnulose 1-phosphate => ATP + L-rhamnulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54476", "l": "1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9620456", "l": "sGC stimulators bind sGC:NO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15723", "l": "glyoxylate + H(+) + NADH + NH4(+) => glycine + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63171", "l": "fumarate + L-cysteine <=> S-(2-succino)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709842", "l": "MAVS binds TOMM70 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39011", "l": "a triacyl-sn-glycerol(in) = a triacyl-sn-glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10370", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5227009", "l": "ABCF1 binds EIF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16997", "l": "3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol = 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}, {"i": "EC:2.8.2.31", "l": "\"petromyzonol sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17016", "l": "H(+) + phosphoenolpyruvate <=> 3-phosphonopyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660666", "l": "CBP and p300 binds NF-kB complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8856945", "l": "PP2A methylation by LCMT1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33703", "l": "(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA = CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62702", "l": "acetoacetate + H(+) + naphthalene-1,3,6,8-tetrol => H2O + naphtopyrone YWA1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44323", "l": "1-decanoylglycerol + H2O <=> decanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173636", "l": "Formation of classic pathway C5 convertase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052610", "l": "beta-cryptoxanthin hydroxylase activity", "d": ["Catalysis of the reaction: beta-cryptoxanthin + a reduced electron acceptor + oxygen = zeaxanthin + an oxidized electron acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9659820", "l": "RB1 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21206", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester => a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709098", "l": "DHFR dimer reduces FOLA to DHF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17443", "l": "2-oxo-3-sulfanylpropanoate + L-glutamate => 2-oxoglutarate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156682", "l": "PLK1 phosphorylates NUDC (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37760", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810392", "l": "TMEM55B translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23195", "l": "Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72232", "l": "chloride(out) + N-methyl-L-proline(out) + 2 Na(+)(out) => chloride(in) + N-methyl-L-proline(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977605", "l": "Factor H displaces Bb (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788999", "l": "HV1-mediated H+ transfer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015284", "l": "fructose uniporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395992", "l": "p-T,4S-IRF3 is dimerized (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419644", "l": "Transphosphorylation of pLIMK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130619", "l": "TGN-lysosomal vesicle coat assembly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112429", "l": "Formation of FACT complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031896", "l": "V2 vasopressin receptor binding", "d": ["Binding to a V2 vasopressin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229343", "l": "AXIN is phosphorylated in the destruction complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30114", "l": "Fe(III)-enterobactin + H(+) + 3 H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168638", "l": "Activated IKK phosphorylates I-kappaB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874082", "l": "MET phosphorylates PTK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54271", "l": "2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 <=> (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60001", "l": "hydroxymethylphosphonate + O2 => formate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804229", "l": "JMY, TTC5 and EP300 bind (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102968", "l": "10-hydroxygeranial oxidoreductase activity", "d": ["Catalysis of the reaction: (6E)-8-hydroxygeranial + NADP <=> (6E)-8-oxogeranial + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004556", "l": "alpha-amylase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64417", "l": "D-xylofuranose + NADP(+) => D-xylono-1,4-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10448", "l": "2-oxoglutarate + a flavanone + O2 = a flavone + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48974", "l": "ADP + H(+) + phosphate + phosphite(in) => ATP + H2O + phosphite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34661", "l": "3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => C30 botryococcene + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20518", "l": "UDP-N-acetyl-alpha-D-glucosamine => UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74917", "l": "a (2E)-2-fatty-enoyl-AMP + diphosphate => a (2E)-enoyl fatty acid + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71998", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O <=> diphosphate + preaspterpenacid acid I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68004", "l": "AH2 + chloroethene = A + chloride + ethene + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13919", "l": "(1R,4S)-menthone + H(+) + NADPH => (-)-menthol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701147", "l": "TRPV1 binds TRPV1 blockers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63112", "l": "A + ascofuranol = AH2 + ascofuranone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697085", "l": "RNAP transcribes Mtb RNA polyanion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6790454", "l": "SUMOylation of XPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37325", "l": "glycine + L-methionine => glycyl-L-methionine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23027", "l": "[(1->4)-beta-D-glucosyl](n) + phosphate <=> [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51888", "l": "2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH", "d": []}, {"i": "EC:1.1.1.404", "l": "\"tetrachlorobenzoquinone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74508", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B => (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30968", "l": "9,9',15-tri-cis-zeta-carotene => 9,9'-di-cis-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31545", "l": "2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside) => all-trans-zeaxanthin + 2 UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15976", "l": "3'-phosphoadenylyl sulfate + estrone <=> adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2025890", "l": "Calcineurin binds NFATC1,2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.26", "l": "\"HECT-type E3 ubiquitin transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54731", "l": "acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] <=> malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800298", "l": "HGF dimer binds MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15281", "l": "lathosterol = 5alpha-cholest-8-en-3beta-ol", "d": []}, {"i": "EC:5.3.3.5", "l": "\"cholestenol Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33936", "l": "2 N(omega)-hydroxy-L-arginine + NADH + 2 O2 => H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047721", "l": "indoleacetate-lysine synthetase activity", "d": ["Catalysis of the reaction: (indol-3-yl)acetate + L-lysine + ATP = N(6)-[(indole-3-yl)acetyl]-L-lysine + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029531", "l": "Expression of ABCG5 regulated by NR1H2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58796", "l": "a flavonol 7-O-beta-D-glucoside + malonyl-CoA = a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015475", "l": "adhesin autotransporter activity", "d": ["Enables the transfer of adhesin from the periplasm to the external milieu; the adhesin and the porin are the N- and C-terminal regions of the same protein, respectively."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51248", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51296", "l": "a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(R)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21849", "l": "(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide => (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75122", "l": "all-trans-13,14-dihydroretinal + H2O + NAD(+) <=> all-trans-13,14-dihydroretinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026918", "l": "Lipoxygenase oxidises 17(S)-Hp-DHA to 7(S),17(S)-diHp-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928594", "l": "SFKs phosphorylate GIT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34277", "l": "3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine => 2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228411", "l": "Clathrin-mediated endocytosis of tetX HC:LC:gangliosides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41731", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-606326", "l": "HJURP:CENPA complex localizes to the centromere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54453", "l": "a 5,6-dihydrouridine in tRNA + NAD(+) => a uridine in tRNA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392751", "l": "L1 linked to actin cytoskeleton by ankyrin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013024", "l": "RHOB binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64242", "l": "CoA + H(+) + N-octanoylglycine => glycine + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48334", "l": "a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42233", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41833", "l": "(2E)-hexenoyl-[ACP] + H(+) + NADPH => hexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429955", "l": "CCR4-NOT complex deadenylates mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691421", "l": "BTK binds BTK inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371435", "l": "Constitutive phosphorylation by GSK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27914", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047357", "l": "UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + UDP-D-galactose = H+ + UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine + UMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10972", "l": "D-hexose + H(+) + phosphoramidate = alpha-D-hexose 1-phosphate + NH4(+)", "d": []}, {"i": "EC:2.7.1.62", "l": "\"phosphoramidate--hexose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11632", "l": "AH2 + L-selenocysteine = A + H(+) + hydrogenselenide + L-alanine", "d": []}, {"i": "EC:4.4.1.16", "l": "\"selenocysteine lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47509", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADH => isolithocholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55721", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] => 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.-", "l": "\"Intramolecular lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47754", "l": "5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine => 5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18640", "l": "H2 + NADP(+) <=> H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1170539", "l": "Prolactin receptor is internalized (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1006169", "l": "Factor H binds host cell surface markers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37229", "l": "(E)-1,3-pentadiene + CO2 => (E,E)-sorbate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801087", "l": "TP53 binds the RABGGTA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038545", "l": "miR-613 binds to the 3'UTR of the NR1H3 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395517", "l": "NADPH transfers electrons to FDXR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993802", "l": "HLCS biotinylates PC:Mn2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30427", "l": "(2E,6E)-farnesyl diphosphate = (+)-germacrene D + diphosphate", "d": []}, {"i": "EC:4.2.3.77", "l": "\"(+)-germacrene D synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204798", "l": "Interaction of Tie2 and p85 of PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47446", "l": "(5Z)-tetradecenoyl-CoA + acetyl-CoA => 3-oxo-(7Z-hexadecenoyl)-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38783", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39164", "l": "3-oxohexadecanoyl-CoA + H(+) + NADPH => (3R)-hydroxyhexadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35907", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59182", "l": "2 AMP + H(+) => 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981606", "l": "Myoglobin binds oxygen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73797", "l": "diphosphate + isoechinulin A => dimethylallyl diphosphate + neoechinulin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22468", "l": "GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate", "d": []}, {"i": "EC:3.5.4.29", "l": "\"GTP cyclohydrolase IIa\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052772", "l": "brefeldin A esterase activity", "d": ["Catalysis of the hydrolysis of brefeldin A to produce brefeldin A acid. Brefeldin A is also known as gamma,4-dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid lambda-lactone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64639", "l": "benzoyl-CoA + butan-1-ol <=> butyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759158", "l": "SQSTM1 oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799431", "l": "TP53 binds HIPK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170674", "l": "Dissociation of the Gi alpha:G olf complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28682", "l": "3-demethylubiquinol-8 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33217", "l": "all-trans-heptaprenyl diphosphate + 3 diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106614", "l": "Duplex miRNA is loaded into Argonaute (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102669", "l": "isoflavone-7-O-glucoside beta-glucosidase activity", "d": ["Catalysis of the reaction: daidzein 7-O-beta-D-glucoside + H2O <=> daidzein + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70751", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49484", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22316", "l": "13-hydroxydocosanoate + UDP-alpha-D-glucose = 13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.158", "l": "\"13-hydroxydocosanoate 13-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904047", "l": "S-adenosyl-L-methionine binding", "d": ["Binding to S-adenosyl-L-methionine."]}, {"i": "REACT:R-HSA-947535", "l": "Cyclisation of GTP to precursor Z (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50630", "l": "a 3-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70630", "l": "H2O + N(6)-dodecanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-dodecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9620103", "l": "ALDH2 transforms GTN to NO (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0031883", "l": "taste receptor binding", "d": ["Binding to a taste receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.135", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61427", "l": "cis-cis-nepetalactol + NAD(+) <=> cis-cis-nepetalactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9659611", "l": "ANO1 inhibitors bind ANO1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40287", "l": "ATP + CoA + decanedioate = AMP + decanedioyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904408", "l": "melatonin binding", "d": ["Binding to melatonin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46741", "l": "7-dehydrodesmosterol + H(+) + NADPH => desmosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16508", "l": "chorismate <=> 4-hydroxybenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19434", "l": "ATP + D-gluconate => 6-phospho-D-gluconate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41486", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009672", "l": "auxin:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: auxin(out) + H+(out) = auxin(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008412", "l": "4-hydroxybenzoate octaprenyltransferase activity", "d": ["Catalysis of the reaction: farnesylfarnesylgeranyl diphosphate + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55255", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine <=> 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21518", "l": "piperitenone => isopiperitenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56583", "l": "6-thioguanine + S-adenosyl-L-methionine <=> 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.95", "l": "\"snake venom factor V activator\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0017081", "l": "chloride channel regulator activity", "d": ["Binds to and modulates the activity of a chloride channel."]}, {"i": "REACT:R-HSA-383190", "l": "HCO3- transport through ion channel (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696960", "l": "USP49 deubiquitinates H2B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202129", "l": "HSP90 binds eNOS:Caveolin-1:CaM complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814409", "l": "CK2 phosphorylates PDCL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850997", "l": "TRIM27 binds PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19269", "l": "2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.31", "l": "\"2-furoate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102102", "l": "homocarnosine synthase activity", "d": ["Catalysis of the reaction: gamma-aminobutyric acid + L-histidine + ATP = H+ + homocarnosine + ADP + hydrogenphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44819", "l": "1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-12 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18002", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102804", "l": "oripavine 6-O-demethylase activity", "d": ["Catalysis of the reaction: oripavine + 2-oxoglutarate + O2 <=> morphinone + formaldehyde + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140078", "l": "class I DNA-(apurinic or apyrimidinic site) endonuclease activity", "d": ["Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21886", "l": "H(+) + sulfate + thiosulfate => H2O + trithionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683593", "l": "ATG7:ATG3:LC3 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432143", "l": "PECAM-1 binds PP2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23129", "l": "4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68184", "l": "a medium-chain fatty acyl-CoA + H2O = a medium chain fatty acid + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.19", "l": "\"ADP-dependent medium-chain-acyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10155", "l": "ATP + hydrogencarbonate + NH4(+) <=> ADP + carbamoyl phosphate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1445143", "l": "RAB8A,10,13,14 hydrolyze GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018798", "l": "RHOV binds GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052606", "l": "chlorophyllide a oxygenase activity", "d": ["Catalysis of the reaction: chlorophyllide a + NADPH + O2 + 2 H+ = 7-hydroxychlorophyllide a + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761047", "l": "HEYL binds CDH11 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20003", "l": "glycolate + 2 H(+) + NADH => glycolaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17595", "l": "2-oxoglutaramate + L-phenylalanine => 3-phenylpyruvate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470010", "l": "Dimerization of STATs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8957241", "l": "TP73 tetramer translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390595", "l": "Calcium Binds Troponin-C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69712", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphinganine + H2O => beta-D-glucose + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69794", "l": "D-phenylalanyl-tRNA(Phe) + H2O <=> D-phenylalanine + H(+) + tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47312", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36621", "l": "CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine => 2-hydroxydocosanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32227", "l": "(6R)-NADPHX = (6S)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203862", "l": "Dicer cleaves pre-miRNA to yield duplex miRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51485", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034000", "l": "chondroitin-sulfate-ABC endolyase activity", "d": ["Catalysis of the endolytic cleavage of beta-1,4-galactosaminic bonds between N-acetylgalactosamine and either D-glucuronic acid or L-iduronic acid to produce a mixture of Delta4-unsaturated oligosaccharides of different sizes that are ultimately degraded to Delta4-unsaturated tetra- and disaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944569", "l": "miR-25 microRNA binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.958976004066542", "identifiers": [{"i": "GO:0019203", "l": "carbohydrate phosphatase activity", "d": ["Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853496", "l": "SCF:FBXL7 binds AURKA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938773", "l": "RNF144A polyubiquitinates PRKDC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31979", "l": "NADPH + O2 + trimethylamine = H2O + NADP(+) + trimethylamine N-oxide", "d": []}, {"i": "EC:1.14.13.148", "l": "\"trimethylamine monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24425", "l": "2 glutathione + L-dehydroascorbate => glutathione disulfide + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56343", "l": "ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28187", "l": "aminoacetone + H2O + O2 => H2O2 + methylglyoxal + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76113", "l": "4-methylumbelliferone + D-glucuronate => 4-methylumbelliferone beta-D-glucuronate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73085", "l": "S-adenosyl-L-homocysteine + velutin => chrysoeriol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684008", "l": "NBN binds KPNA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64730", "l": "(7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate => (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20430", "l": "apigenin + S-adenosyl-L-methionine => acacetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22422", "l": "2 H(+) + maleylacetate + NADH => cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103003", "l": "oleate peroxygenase activity", "d": ["Catalysis of the reaction: oleate + a lipid hydroperoxide <=> 9,10-epoxystearate + a lipid alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935972", "l": "TJP1 (ZO-1) gene expression is stimulated by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23831", "l": "2-dehydro-D-gluconate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237160", "l": "MTA is cleaved and phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102105", "l": "demethoxycurcumin synthase activity from feruloylacetyl-CoA", "d": ["Catalysis of the reaction: feruloylacetyl-CoA + 4-coumaryl-CoA + H2O = demethoxycurcumin + 2 coenzyme A + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66186", "l": "3',5'-cyclic AMP(out) + ADP + H(+) + phosphate => 3',5'-cyclic AMP(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21128", "l": "S-adenosyl-L-methionine + zymosterol = fecosterol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32118", "l": "2-oxoglutarate + DIBOA beta-D-glucoside + O2 <=> CO2 + succinate + TRIBOA beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28441", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + tetradecanoyl-[ACP] <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44691", "l": "a 2-acylglycerol + H2O <=> a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865505", "l": "SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229343", "l": "AXIN is phosphorylated in the destruction complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52437", "l": "a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA => 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75558", "l": "(-)-cyatha-3,12-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> erinacol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451511", "l": "TLR15 binds to recognized ligand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33238", "l": "2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 <=> 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684008", "l": "NBN binds KPNA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164522", "l": "Terminal (3' end) cleavage of viral DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20486", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038174", "l": "interleukin-17A receptor activity", "d": ["Combining with the cytokine interleukin-17A and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10148", "l": "blasticidin S + H(+) + H2O = deaminohydroxyblasticidin S + NH4(+)", "d": []}, {"i": "EC:3.5.4.23", "l": "\"blasticidin-S deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53197", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190520", "l": "Association of Golgi  transport vesicles with microtubules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68000", "l": "1,1-dichloroethene + AH2 = A + chloride + chloroethene + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34999", "l": "ADP(in) + ATP(out) = ADP(out) + ATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40225", "l": "4,8-dimethylnonanoate + CoA + H(+) => 4,8-dimethylnonanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75511", "l": "acetyl-CoA + S-benzyl-L-cysteine = CoA + H(+) + N-acetyl-S-benzyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.764920414113355", "identifiers": [{"i": "GO:0005262", "l": "calcium channel activity", "d": ["Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11471", "l": "(S)-3-methyl-2-oxopentanoate + L-valine <=> 3-methyl-2-oxobutanoate + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50179", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.10", "l": "\"magnesium dechelatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49325", "l": "(5R,6S)-5,6-epoxi-capsanthin => all-trans-capsorubin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49199", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol <=> 25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28841", "l": "H(+)(in) + Zn(2+)(out) => H(+)(out) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110322", "l": "Formation of Pol zeta complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848414", "l": "Activated PTK6 binds CDKN1B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37536", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865275", "l": "PDGF-BB clevage by Furin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.60", "l": "\"N-acylmannosamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72899", "l": "4-O-demethylbarbatate + S-adenosyl-L-methionine = proatranorin I + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19626", "l": "L-threonine => acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112395", "l": "Abortive termination of elongation after arrest (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.56", "l": "\"inositol-polyphosphate 5-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917839", "l": "apo-Transferrin dissociates from the receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33292", "l": "L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35437", "l": "cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP => cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416683", "l": "SEMA3E binds to PLXND1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295632", "l": "PPA2A dephosphorylates SPRY2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786190", "l": "CMBL hydrolyses OM to OLMS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68093", "l": "a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA => a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35935", "l": "2 ATP + L-proline + L-tryptophan = 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72616", "l": "H(+)(out) + L-alanyl-L-valine(out) => H(+)(in) + L-alanyl-L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29398", "l": "H2O + UTP <=> diphosphate + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43852", "l": "H(+) + malonyl-CoA + triacontanoyl-CoA = 3-oxo-dotriacontanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19426", "l": "H(+) + imidazole-4-acetate + NADH + O2 => 5-hydroxyimidazole-4-acetate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59454", "l": "a long-chain fatty aldehyde + H(+) + NADPH => a long-chain primary fatty alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981892", "l": "Active G alpha (z) binds RGS proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793666", "l": "MDM2 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186773", "l": "PDGF dimer binds two receptors simultaneously (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647980", "l": "mature RAS proteins translocate to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48976", "l": "5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 = CO2 + H2O + NAD(+) + pyocyanin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416929", "l": "PTGFR binds PGF2a (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46285", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23773", "l": "(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) => 2,3-dihydroxy-p-cumate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62962", "l": "7-dehydrocholesterol(out) => 7-dehydrocholesterol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419451", "l": "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685602", "l": "NCR3LG1 binds NCR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29252", "l": "2 H(+)(out) + Na(+)(in) => 2 H(+)(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61931", "l": "(R)-miconazole(in) + ATP + H2O <=> (R)-miconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684140", "l": "ATM phosphorylates RBBP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23906", "l": "5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide] => an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59863", "l": "3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534365", "l": "Slo3 Potassium Transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45589", "l": "a long-chain fatty acid + ATP + holo-[ACP] => a long-chain fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710263", "l": "GZMB cleaves GSDME (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626945", "l": "CREBBP acetylates FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58939", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH <=> all-trans-lycopaoctaene + 2 diphosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37410", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28924", "l": "H(+)(in) + L-phenylalanine(in) => H(+)(out) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35211", "l": "dIDP + H2O = dIMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19289", "l": "H2O + sucrose 6(F)-phosphate = phosphate + sucrose", "d": []}, {"i": "EC:3.1.3.24", "l": "\"sucrose-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17260", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vinorine <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9736953", "l": "FURIN translocates to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19691", "l": "(S)-lactaldehyde + dihydroxyacetone phosphate => L-rhamnulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74622", "l": "CMP(in) + UMP(out) <=> CMP(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0045296", "l": "cadherin binding", "d": ["Binding to cadherin, a type I membrane protein involved in cell adhesion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20659", "l": "4-chlorophenylacetate + NH4(+) => 4-chlorophenylacetonitrile + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31763", "l": "a 2-oxocarboxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid", "d": []}, {"i": "EC:2.6.1.88", "l": "\"methionine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25740", "l": "N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23553", "l": "2-methylpropane-1,2-diol + NAD(+) => 2-hydroxy-2-methylpropanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21668", "l": "ATP + H2O + sn-glycerol 3-phosphate(out) = ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)", "d": []}, {"i": "EC:7.6.2.10", "l": "\"ABC-type glycerol 3-phosphate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178208", "l": "SMAD7 binds to SMURF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10577", "l": "CTP + H(+) + N-methylethanolamine phosphate => CDP-N-methylethanolamine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853320", "l": "FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19719", "l": "2-phenylethylamine + CO2 => H(+) + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451310", "l": "Activation of Edited Kainate receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2984226", "l": "PLK1 phosphorylates NEK9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63028", "l": "(15Z)-tetracosenamide + H2O = (15Z)-tetracosenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-532603", "l": "Nephrin mediated activation of N-WASP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391936", "l": "EP1 receptor can bind PGE2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73891", "l": "ATP + L-glutamate + spermidine = ADP + gamma-L-glutamylspermidine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549304", "l": "OCT3 mediates renal clearance of organic cations (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050583", "l": "hydrogen dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + H2 = NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21374", "l": "CO2 + ethanol + NH4(+) => H(+) + H2O + urethane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44797", "l": "2-demethylmenaquinol-13 + S-adenosyl-L-methionine => H(+) + menaquinol-13 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75946", "l": "beta-alanine + L-arginine <=> 3-guanidinopropanoate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60472", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = (6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33483", "l": "an acyl-CoA + ergosterol = CoA + ergosteryl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48982", "l": "(2Z,4Z)-2,3-dichloromuconate + 2 H(+) => 3,4-dichlorocatechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166041", "l": "Transfer of LPS onto TLR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009383", "l": "rRNA (cytosine-C5-)-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451826", "l": "YKI binds to EX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9621179", "l": "Cinaciguat binds sGC:NO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22532", "l": "(2E)-octenedioyl-CoA + H2O = (3S)-hydroxyoctanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28533", "l": "H2O + XMP <=> phosphate + xanthosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102964", "l": "S-adenosyl-L-methionine:(S)-corytuberine-N-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-corytuberine + S-adenosyl-L-methionine <=> H+ + magnoflorine + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32558", "l": "(2E)-geranyl diphosphate + H2O <=> (R)-alpha-terpineol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63224", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49403", "l": "H2O + validoxylamine A 7'-phosphate <=> phosphate + validoxylamine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672978", "l": "RAF phosphorylates MAP2K dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67515", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46434", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19153", "l": "apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose = 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP", "d": []}, {"i": "EC:2.4.2.25", "l": "\"flavone apiosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15634", "l": "3,4-dihydroxyphenylacetate + O2 => 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654159", "l": "Activated FGFR2 binds PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44316", "l": "1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73053", "l": "hydrogencarbonate(out) + taurocholate(in) => hydrogencarbonate(in) + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163320", "l": "Association of mTERF with the termination sequence (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0034326", "l": "butanoyltransferase activity", "d": ["Catalysis of the transfer of a butanoyl (CH3-[CH2]2-CO-) group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63457", "l": "(2E,6E,10E)-geranylgeraniol + CTP => (2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65502", "l": "5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine => [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097620", "l": "(R)-mandelate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxy-2-phenylacetate + acceptor = phenylglyoxylate + reduced acceptor."]}, {"i": "RHEA:43112", "l": "(R)-mandelate + NAD(+) = H(+) + NADH + phenylglyoxylate", "d": []}, {"i": "EC:1.1.1.379", "l": "\"(R)-mandelate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74240", "l": "phosphate + solabiose => alpha-D-glucose 1-phosphate + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56751", "l": "an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24898", "l": "2 GTP = 3',3'-c-di-GMP + 2 diphosphate", "d": []}, {"i": "EC:2.7.7.65", "l": "\"diguanylate cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0022848", "l": "acetylcholine-gated monoatomic cation-selective channel activity", "d": ["Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24432", "l": "H2O + oxaloacetate = acetate + H(+) + oxalate", "d": []}, {"i": "EC:3.7.1.1", "l": "\"oxaloacetase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592316", "l": "Initial activation of proMMP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430347", "l": "MigFilin associates with Filamin and F-actin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22621", "l": "H(+) + L-tryptophan + O2 => 3-indoleglycolaldehyde + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15876", "l": "[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65673", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651789", "l": "LIG1 bound to POLB ligates SSB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34205", "l": "aureusidin 6-O-beta-glucoside + H2O => 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54414", "l": "a 3-oxo-Delta(4)-steroid + H(+) + NADPH => a 3-oxo-5beta-steroid + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20520", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21153", "l": "trans-4-hydroxy-L-proline => cis-4-hydroxy-D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15235", "l": "Fe(II)-[cytochrome c] + 2 H(+) + nitrite => Fe(III)-[cytochrome c] + H2O + nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755303", "l": "26S proteasome degrades HIFalpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44248", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75888", "l": "ADP-1-deoxy-1,O(4)-didehydro-D-ribose + L-arginyl-[protein] => ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38878", "l": "uridine(2604) in 23S rRNA <=> pseudouridine(2604) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759158", "l": "SQSTM1 oligomerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20804", "l": "2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) = H(+) + hydrogencarbonate + NADH + propanoyl-CoA", "d": []}, {"i": "EC:1.2.1.27", "l": "\"methylmalonate-semialdehyde dehydrogenase (CoA acylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193646", "l": "NGF binding to p75NTR inactivates RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201669", "l": "Beta-catenin translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697057", "l": "esxG binds esxH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34592", "l": "Co-precorrin-7 + S-adenosyl-L-methionine => Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5213464", "l": "RIPK1 is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866277", "l": "AP-2 directly binds some endocytic cargo (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54523", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> cycloaraneosene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869438", "l": "Dissociation of clathrin-associated proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65319", "l": "2-oxoglutarate + chrodrimanin H + O2 <=> chrodrimanin E + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69138", "l": "2 H2O2 + 2 NH4(+) + spermine dialdehyde => 2 H2O + 2 O2 + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730840", "l": "Activation of RAC1 by VAV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3204303", "l": "MRE11 binds cytosolic DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53997", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20201", "l": "ATP + H2O + L-phenylalanine = AMP + D-phenylalanine + diphosphate + H(+)", "d": []}, {"i": "EC:5.1.1.11", "l": "\"phenylalanine racemase (ATP-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097023", "l": "fructose 6-phosphate aldolase activity", "d": ["Catalysis of the reaction: D-fructose-6-phosphate = dihydroxyacetone + D-glyceraldehyde-3-phosphate."]}, {"i": "RHEA:28002", "l": "beta-D-fructose 6-phosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0140818", "l": "mRNA 5'-phosphatase activity", "d": ["A 5'-end triphospho-[mRNA] + H2O = a 5'-end diphospho-[mRNA] + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674093", "l": "PDGFRs bind type I TKI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49479", "l": "2 H2O + L-1-piperideine-6-carboxylate + NAD(+) <=> H(+) + L-2-aminoadipate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32363", "l": "L-gulono-1,4-lactone + O2 = H(+) + H2O2 + L-ascorbate", "d": []}, {"i": "EC:1.1.3.8", "l": "\"L-gulonolactone oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156699", "l": "Inactivation of Wee1 kinase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802942", "l": "RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72124", "l": "Na(+)(out) + O-butanoyl-(R)-carnitine(out) => Na(+)(in) + O-butanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.-", "l": "\"Endopeptidases of unknown catalytic mechanism\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351894", "l": "Caspase mediated cleavage of BAP31 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64086", "l": "2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2 => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47051", "l": "a quinone + shikimate <=> 3-dehydroshikimate + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043994", "l": "histone H3K23 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11121", "l": "cyanate + 3 H(+) + hydrogencarbonate => 2 CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781926", "l": "Defective PMM2 does not isomerise Man6P to Man1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69114", "l": "2-oxoadipate + glycine => glyoxylate + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63796", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39713", "l": "2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) => O2 + 2 reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39095", "l": "(3S)-hydroxydecanedioyl-CoA + NAD(+) = 3-oxodecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12664", "l": "(R)-carnitine + hexadecanoyl-CoA <=> CoA + O-hexadecanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16196", "l": "an (R)-2-haloacid + H2O <=> a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76036", "l": "(S)-cis-N-methylstylopine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + protopine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25149", "l": "H(+) + H2O + quinolinate => (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188544", "l": "Assembly of M2 tetramers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32503", "l": "linalool + O2 + reduced [NADPH--hemoprotein reductase] = (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48932", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b = CMP + ganglioside GQ1b + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13635", "l": "ADP + gamma-L-glutamylputrescine + H(+) + phosphate => ATP + L-glutamate + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48718", "l": "13-oxo-(9Z,11E)-octadecadienoate + H2O => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34387", "l": "beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose = beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43137", "l": "guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75449", "l": "(9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909720", "l": "IFN alpha/beta binds to IFNAR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15076", "l": "3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O <=> D-glucuronate + N(2),6-disulfo-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15132", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52293", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167427", "l": "Opioid dissociates from MOR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803836", "l": "FGFR2b-specific alternative splicing produces FGFR2b transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40229", "l": "A47934 + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + desulfo-A47934", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74344", "l": "O-hexanoyl-(R)-carnitine(in) => O-hexanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917841", "l": "Acidification of Tf:TfR1 containing endosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11968", "l": "AH2 + kynurenate + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + A", "d": []}, {"i": "EC:1.14.99.2", "l": "\"kynurenine 7,8-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68793", "l": "alpha-NAD(+) + H2O => ADP-D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809010", "l": "COPI vesicle uncoating (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25308", "l": "7,8-dihydroneopterin 3'-phosphate + H2O => 7,8-dihydroneopterin + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45799", "l": "(3R)-3-hydroxybutanoyl-CoA + NADP(+) <=> acetoacetyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036317", "l": "tyrosyl-RNA phosphodiesterase activity", "d": ["Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047182", "l": "alcohol O-cinnamoyltransferase activity", "d": ["Catalysis of the reaction: an alcohol + 1-O-trans-cinnamoyl-beta-D-glucopyranose = beta-D-glucose + alkyl cinnamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805981", "l": "HMGB1 release from cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850534", "l": "PDCL promotes G-protein beta 5 folding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2106614", "l": "Duplex miRNA is loaded into Argonaute (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66479", "l": "gypsogenate + UDP-alpha-D-glucose <=> gypsogenate 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17284", "l": "(2S)-4-acetamido-2-aminobutanoate <=> H2O + L-ectoine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877153", "l": "STARD7 binds PC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13930", "l": "agmatine + H2O => putrescine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48589", "l": "2 H2O + 2 leukotriene A4 + O2 => 2 lipoxin B4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658430", "l": "NF1 is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38902", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9817575", "l": "ERO1B oxidizes P4HB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33231", "l": "H2O2 + heme b = heme d cis-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13808", "l": "A + a 3-oxo-5alpha-steroid <=> a 3-oxo-Delta(4)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689000", "l": "AADAC deacetylates PHEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74351", "l": "2 (S)-lactate(in) + prostaglandin E3(out) = 2 (S)-lactate(out) + prostaglandin E3(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32425", "l": "(R)-carvone + AH2 => (1R,4R)-dihydrocarvone + A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0016168", "l": "chlorophyll binding", "d": ["Binding to a chlorophyll; a compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420206", "l": "Phosphorylation of SRC-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63824", "l": "2 3-(4-hydroxyphenyl)pyruvate = aspulvinone E + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975106", "l": "Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173636", "l": "Formation of classic pathway C5 convertase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49529", "l": "(ethylene terephthalate)(n) + H2O => (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114553", "l": "Activation of conventional Protein Kinase C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36294", "l": "3-methylxanthine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73272", "l": "rhamnetin + S-adenosyl-L-methionine => H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21136", "l": "(R)-carnitine + acetyl-CoA = CoA + O-acetyl-(R)-carnitine", "d": []}, {"i": "EC:2.3.1.7", "l": "\"carnitine O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35969", "l": "12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29248", "l": "3 H(+)(out) + 2 Na(+)(in) => 3 H(+)(in) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007999", "l": "RUNX2 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35839", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = a cardiolipin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36616", "l": "2-hydroxyoctadecanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688294", "l": "SIRT5 deacetylates Cytochrome C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655483", "l": "USP1 autocleavage (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23577", "l": "(R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] => berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29196", "l": "(S)-dihydroorotate + a menaquinone => a menaquinol + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71674", "l": "glycyl-L-glutamine(out) + H(+)(out) <=> glycyl-L-glutamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334097", "l": "DNMT3B:DNMT3L methylates cytosine in DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2545203", "l": "Deacetylation of cleaved cohesin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102100", "l": "mycothiol-arsenate ligase activity", "d": ["Catalysis of the reaction: arsenate + mycothiol <=> mycothiol-arsenate conjugate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193668", "l": "p75NTR and RHOA-GDI interact (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247843", "l": "secretion of WNT ligands (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49513", "l": "2-(phosphinatomethylidene)butanedioate + H2O => phosphinomethylisomalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869683", "l": "oxPL binds LBP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23283", "l": "acetyl-CoA + cysteamine <=> CoA + S-acetylcysteamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167148", "l": "TFIIS-mediated recovery of elongation from arrest (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22093", "l": "(3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin] => 15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73392", "l": "H(+)(in) + phosphate(in) + sulfate(out) => H(+)(out) + phosphate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676168", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483174", "l": "PE is methylated to PC by PEMT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726509", "l": "NR3C2 binds fludrocortisone (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769316", "l": "NPAS4 binds NAMPT gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32145", "l": "L-arginine(out) => L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27471", "l": "acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine => H2O + N,N'-diacetylchitobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727305", "l": "mRNA8 is translated to protein 8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.224", "l": "\"acetyl-CoA-benzylalcohol acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166387", "l": "The FA anion diffuses away laterally from UCP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57841", "l": "1D-myo-inositol 1,3-bisphosphate + H2O => 1D-myo-inositol 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807008", "l": "PTPRJ dephosphorylates MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21863", "l": "3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2186771", "l": "RNF111 binds SMAD7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013143", "l": "RAC1 GEFs activate RAC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16127", "l": "ADP + D-fructose 6-phosphate + H(+) => ATP + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30627", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) = (2S)-2-acetolactate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37069", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71060", "l": "L-arginine(in) + L-leucine(out) => L-arginine(out) + L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452091", "l": "Phosphorylation of IL2RB Y338 enables SHC recruitment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69127", "l": "Formation of the Flap Intermediate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182986", "l": "CBL-mediated ubiquitination of CIN85 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2574845", "l": "AJUBA binds centrosome-associated AURKA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205136", "l": "GTP-bound RAC contributes to JNK activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14047", "l": "3-(hydrohydroxyphosphoryl)pyruvate + CO2 => 1-carboxyvinyl carboxyphosphonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29265", "l": "L-leucine(out) + Na(+)(out) => L-leucine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63597", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928578", "l": "EPH receptors autophosphorylate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51505", "l": "a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose => a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52959", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate <=> hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43249", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18695", "l": "6-aminopenicillanate + a carboxylate => a penicillin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734713", "l": "ORC6 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59199", "l": "holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP <=> AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64217", "l": "2-carboxy-L-lyxonate + H(+) => CO2 + L-lyxonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30410", "l": "hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] <=> oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73895", "l": "ATP + L-glutamate + spermine = ADP + gamma-L-glutamylspermine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205244", "l": "Recruitment of CBL to KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029690", "l": "Caspase-6 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34122", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA <=> 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65645", "l": "(4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156682", "l": "PLK1 phosphorylates NUDC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950737", "l": "IL23R binds JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18807", "l": "[DsbA protein]-dithiol + [protein]-disulfide => [DsbA protein]-disulfide + [protein]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3266557", "l": "Factor I cleaves iC3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49149", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803063", "l": "RNASEs bind bacterial LPS, PGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68264", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70388", "l": "3-oxosphinganine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35580", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8 => anthocyanin A11 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72065", "l": "glycoursodeoxycholate(in) + 2 Na(+)(in) => glycoursodeoxycholate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709406", "l": "CO binds to Cytochrome c oxidase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70154", "l": "6-deoxo-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-28-norcastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22061", "l": "(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43317", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029690", "l": "Caspase-6 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050172", "l": "phenylalanine 2-monooxygenase activity", "d": ["Catalysis of the reaction: L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034563", "l": "2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + O2 = 4-hydroxyphenacyl alcohol + 4-hydroxybenzoate + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72564", "l": "butanoate(out) + dehydroepiandrosterone 3-sulfate(in) => butanoate(in) + dehydroepiandrosterone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.36", "l": "\"alcohol dehydrogenase (nicotinoprotein)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.330199557084356", "identifiers": [{"i": "GO:0015293", "l": "symporter activity", "d": ["Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29289", "l": "2 H(+)(out) + L-aspartate(out) => 2 H(+)(in) + L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27918", "l": "H2O + NADP(+) + propanal = 2 H(+) + NADPH + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63728", "l": "candesartan + UDP-alpha-D-glucuronate = candesartan-2-N-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32466", "l": "glycine + 2 S-adenosyl-L-methionine <=> 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250930", "l": "B-WICH recruits histone acetyltransferases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52622", "l": "2,2-dimethylpropanoyl-CoA => 3-methylbutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008825", "l": "cyclopropane-fatty-acyl-phospholipid synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48367", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62943", "l": "H2O + N(4)-acetylcytosine <=> acetate + cytosine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41516", "l": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57254", "l": "glycolate + GTP + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0141052", "l": "histone H3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a modified lysine residue of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69212", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ATP + L-glutamate = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59114", "l": "ADP + H(+) + O-phospho-L-serine => ATP + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45287", "l": "eicosanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-eicosanoyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21407", "l": "chloride + O2 <=> chlorite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018846", "l": "styrene-oxide isomerase activity", "d": ["Catalysis of the reaction: styrene oxide = phenylacetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801109", "l": "CHM binds RGGT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32963", "l": "2-oxoglutaramate + H2O = 2-oxoglutarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678981", "l": "TLR9 processing at neutral pH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874078", "l": "PTK2 autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58108", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981355", "l": "RASA1 binds RAS:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879909", "l": "Activation of STAT5a/b by JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17267", "l": "cis-aconitate => trans-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047306", "l": "D-methionine-pyruvate transaminase activity", "d": ["Catalysis of the reaction: D-methionine + pyruvate = 4-methylthio-2-oxobutanoate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805035", "l": "TP53 binds STK11 and NUAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372529", "l": "Release of acetylcholine at the synapse (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57137", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48509", "l": "cholate + NADP(+) => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0001637", "l": "G protein-coupled chemoattractant receptor activity", "d": ["Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53848", "l": "NAD(+) + taurocholate = 7-oxo-taurodeoxycholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.55", "l": "\"pitrilysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61211", "l": "8-nitro-cGMP + L-cysteinyl-[protein] <=> H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68699", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052914", "l": "16S rRNA (guanine(1207)-N(2))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1207) in 16S rRNA = N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606789", "l": "ARSB hydrolyses DS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66554", "l": "5-serotonyl-L-glutamyl-[protein] + NH4(+) => L-glutaminyl-[protein] + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31210", "l": "FAD + H(+) + hexanoyl-CoA <=> (2E)-hexenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72360", "l": "glutarate(in) + succinate(out) => glutarate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27424", "l": "(2E,6E)-farnesyl diphosphate <=> (3E,6E)-alpha-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65061", "l": "NADP(+) + taurochenodeoxycholate => 7-oxotaurolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32590", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 <=> (3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3132759", "l": "TCN1 binds RCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416358", "l": "G alpha (q) inhibits PI3K alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11916", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602458", "l": "Activation of proMMP10 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482772", "l": "Release of platelet cytosolic components (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3266557", "l": "Factor I cleaves iC3b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36953", "l": "(9Z)-heptadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5623643", "l": "RDH13 reduces atRAL to atROL (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34555", "l": "a (2S)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0019961", "l": "interferon binding", "d": ["Binding to an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.356", "l": "\"GDP-L-colitose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132221", "l": "C5b:C6:C7:C8 and C9 bind to form membrane attack complex (MAC) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354173", "l": "Activation of Rap1 by cytosolic GEFs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0099100", "l": "G-protein gated monoatomic cation channel activity", "d": ["A cation channel activity that is gated by binding of a G-protein beta-gamma dimer."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12889", "l": "L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.45", "l": "\"L-gulonate 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050080", "l": "malonyl-CoA decarboxylase activity", "d": ["Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49460", "l": "(2Z,4E)-2-aminomuconate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)", "d": []}, {"i": "EC:3.5.99.11", "l": "\"2-aminomuconate deaminase (2-hydroxymuconate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645428", "l": "ALPK1 binds ADP-heptose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55460", "l": "11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448744", "l": "IL20RA binds IL20RB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236947", "l": "Egress of internalized antigen to the cytosol via sec61 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39524", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA => (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58880", "l": "4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29904", "l": "ATP + D-ribose(out) + H2O => ADP + D-ribose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55716", "l": "(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O = (9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109857", "l": "MAP2K1 binds MAPK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47935", "l": "(2S)-3-sulfolactaldehyde + H2O + NAD(+) <=> (2S)-3-sulfolactate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52031", "l": "a jasmonyl-L-amino acid + H2O <=> a jasmonate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70854", "l": "H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out) <=> H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47478", "l": "(2E)-tetradecenoyl-CoA => (3E)-tetradecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29409", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+) => 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018564", "l": "carbazole 1,9a-dioxygenase activity", "d": ["Catalysis of the reaction: carbazole + NADH + O2 + H+ = NAD+ + 2'-aminobiphenyl-2,3-diol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677050", "l": "Formation of the GCN5-ATAC complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62298", "l": "(+)-malbrancheamide + 2 FADH2 => (+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656258", "l": "Defective ST3GAL3 does not transfer SA to keratan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19080", "l": "H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] <=> 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50913", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol => 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71318", "l": "chloride(out) + L-serine(out) + 2 Na(+)(out) <=> chloride(in) + L-serine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69491", "l": "O2 + tetradecan-1-ol <=> H2O2 + tetradecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1006143", "l": "CD46 binds C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44981", "l": "(R)-carnitine + butanoyl-CoA => CoA + O-butanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204779", "l": "Interaction of Tie2 with Ang1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848818", "l": "PTK6 phosphorylates CBL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69097", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine => H2O + kynurenate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24143", "l": "guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50145", "l": "ethyl (9Z)-hexadecenoate + H2O => (9Z)-hexadecenoate + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70558", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O <=> L-seryl-[protein] + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948136", "l": "ULK1 Translocates to the mitochondria (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67610", "l": "diphosphate + H(+) + N(6)-methyl-AMP => H2O + N(6)-methyl-ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13600", "l": "1,4-diguanidinobutane + H2O <=> agmatine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22578", "l": "an N-acyl-L-homoserine + H(+) => an N-acyl-L-homoserine lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60204", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28544", "l": "CoA + fluoroacetate + H(+) => fluoroacetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2172666", "l": "RB1 binds condensin II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624798", "l": "LBR binds KPNB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186785", "l": "PDGF-AA clevage by Furin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19088", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42585", "l": "1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34955", "l": "5-(methylsulfanyl)-D-ribose(in) = 5-(methylsulfanyl)-D-ribose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43914", "l": "(25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110011", "l": "Binding of Grb10 to the insulin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0022850", "l": "serotonin-gated monoatomic cation-selective channel activity", "d": ["Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15127", "l": "CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) => acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034798", "l": "fosfomycin 2-L-cysteine ligase activity", "d": ["Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + L-cysteine = hydrogen (1R,2R)-1-L-cysteine-2-hydroxypropylphosphonic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31536", "l": "2-oxoglutarate + L-arginine + O2 => (S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35526", "l": "H(+) + N-ethylmaleimide + NADPH <=> N-ethylsuccinimide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57835", "l": "5-oxopentanoate + H2O + NADP(+) <=> glutarate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11439", "l": "4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 <=> 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067667", "l": "IL6 binds IL6R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56103", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102922", "l": "phenylpropanoyltransferase activity", "d": ["Catalysis of the reaction: baccatin III + (3R)-3-amino-3-phenylpropanoyl-CoA = N-debenzoyl-(3'-RS)-2'-deoxytaxol + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36240", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-2-acyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098613", "l": "methaneselenol methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + methaneselenol => S-adenosyl-L-homocysteine + dimethyl selenide."]}, {"i": "REACT:R-HSA-2408541", "l": "MeSeH is methylated to Me2Se by MeSeH methyltransferase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68610", "l": "Formation of ORC(2-5) complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72668", "l": "O2 + reduced [NADPH--hemoprotein reductase] + secologanin => 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + secoxyloganin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37078", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36884", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674093", "l": "PDGFRs bind type I TKI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43679", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30303", "l": "(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.95", "l": "\"germacrene A hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49739", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate <=> CO2 + deoxyviolacein + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58039", "l": "8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) <=> 8-epi-inunolide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64760", "l": "H2O + S-ethyl-L-cysteine = ethanethiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0015179", "l": "L-amino acid transmembrane transporter activity", "d": ["Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids."]}, {"i": "REACT:R-HSA-212614", "l": "Glutamine transport from astrocytes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66228", "l": "asc-C13-CoA + O2 = asc-DeltaC13-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12424", "l": "(3S)-3-hydroxy-L-aspartate = NH4(+) + oxaloacetate", "d": []}, {"i": "EC:4.3.1.16", "l": "\"threo-3-hydroxy-L-aspartate ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404193", "l": "IGF1R phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51732", "l": "glandicoline B + S-adenosyl-L-methionine = H(+) + meleagrin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14987", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69524", "l": "D-sorbitol + O2 = D-glucose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029471", "l": "Hydrolysis of PC to PA by PLD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44872", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74770", "l": "S-adenosyl-L-methionine + syringetin <=> 3,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66961", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose => beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68947", "l": "esculetin + S-adenosyl-L-methionine <=> H(+) + isoscopoletin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938231", "l": "RUNX1:CBFB binds CREBBP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854408", "l": "APOBR dimer binds VLDLs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429860", "l": "DCP1-DCP2 complex decaps mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15760", "l": "L-homoserine + NAD(+) <=> H(+) + L-aspartate 4-semialdehyde + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950387", "l": "CANX binds EBI3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52658", "l": "a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH => a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12322", "l": "1,2-dihydrovomilenine + 2 H(+) + NADPH => 17-O-acetylnorajmaline + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33781", "l": "6,6-kestotetraose + beta-D-glucose => 6-kestotriose + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050520", "l": "phosphatidylcholine synthase activity", "d": ["Catalysis of the reaction: CDP-diacylglycerol + choline = 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798373", "l": "MDM2 ubiquitinates DYRK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111956", "l": "Calmodulin activates Cam-PDE 1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75427", "l": "eburicol + O2 + reduced [NADPH--hemoprotein reductase] = 32-hydroxyeburicol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031712", "l": "B1 bradykinin receptor binding", "d": ["Binding to a B1 bradykinin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018064", "l": "protein-L-histidine N-tele-methyltransferase activity", "d": ["Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250947", "l": "B-WICH complex binds rDNA promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32136", "l": "2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74045", "l": "L-alanine(out) + L-methionine(in) => L-alanine(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12398", "l": "dTDP-D-galacturonate + 3 H(+) + 2 NADPH => dTDP-D-galactose + H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035978", "l": "Defective HEXA does not cleave the terminal GalNAc from keratan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10003", "l": "H2O + pentanamide <=> NH4(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64846", "l": "(2E)-geranyl benzoate + CoA => (2E)-geraniol + benzoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22978", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28446", "l": "1-deoxy-D-xylulose(in) = 1-deoxy-D-xylulose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53698", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12235", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) <=> [thioredoxin]-dithiol + glycine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002440", "l": "Removal of fibrillar collagen C-propeptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21349", "l": "8 H(+) + 10 malonyl-CoA => 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429732", "l": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007605", "l": "BRCA1 gene expression is inhibited by E2F6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11438", "l": "4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O => 4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51369", "l": "glycine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "59.083802337440083", "identifiers": [{"i": "GO:0016817", "l": "hydrolase activity, acting on acid anhydrides", "d": ["Catalysis of the hydrolysis of any acid anhydride."]}, {"i": "EC:3.6.-.-", "l": "\"Acting on acid anhydrides\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36049", "l": "(R)-glycerate + AH2 + H(+) => A + D-glyceraldehyde + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018446", "l": "pinocarveol dehydrogenase activity", "d": ["Catalysis of the reaction: pinocarveol = pinocarvone + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008946", "l": "oligonucleotidase activity", "d": ["Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160931", "l": "Disassembly of tight junctions (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66993", "l": "3-methylpentanoate + ATP + CoA => 3-methylpentanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50731", "l": "(Z)-(4-hydroxyphenyl)acetaldehyde oxime <=> 4-hydroxyphenylacetonitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654625", "l": "Activated FGFR3 binds SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52096", "l": "9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61736", "l": "steviolmonoside + UDP-alpha-D-glucose = rubusoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22188", "l": "an (R)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64260", "l": "(9Z,12Z)-octadecadienoyl-CoA + glycine = CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52003", "l": "a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + glutathione <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63070", "l": "2 CO2 + 3 CoA + triacetate lactone => acetyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005476", "l": "carnitine:acyl carnitine antiporter activity", "d": ["Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47914", "l": "2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O => 6-deoxy-6-sulfo-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937022", "l": "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693575", "l": "DNA-PKcs autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43502", "l": "D-glucaro-1,5-lactone + H(+) + NADH => beta-D-glucuronate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39518", "l": "(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH <=> (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033999", "l": "chondroitin B lyase activity", "d": ["Catalysis of the reaction: dermatan sulfate = n 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate. This reaction is the eliminative cleavage of dermatan sulfate containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucurosonyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (DeltaUA-GalNAC-4S). Chondroitin sulfate B is also known as dermatan sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853793", "l": "p-5Y-RET complexes bind GRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030280", "l": "structural constituent of skin epidermis", "d": ["The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004028", "l": "3-chloroallyl aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57858", "l": "(E)-6-hydroxyferuloyl-CoA + CO2 + succinate => (E)-feruloyl-CoA + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69152", "l": "Removal of remaining Flap (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45092", "l": "H2O + N-octanoylsphing-4-enine = octanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6786421", "l": "CHIA hydrolyses chitin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869558", "l": "HSPD1 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43707", "l": "ATP + H(+) + tetradecanoate <=> diphosphate + tetradecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67912", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O = 1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64536", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": []}, {"i": "EC:2.7.1.227", "l": "\"inositol phosphorylceramide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694317", "l": "Nsp3, nsp4, and nsp6 produce replicative organelles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981892", "l": "Active G alpha (z) binds RGS proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674018", "l": "BRAP binds RAS:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22514", "l": "hydrogenobyrinate => 3 H(+) + precorrin-8X", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71783", "l": "MDH2 reduces OA to MAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34506", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-epi-alpha-bisabolol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44720", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9640167", "l": "RRAGA,B exchanges GDP for GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45642", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603419", "l": "Activated NTRK3 binds SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42297", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] => a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42612", "l": "a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21550", "l": "acetate + L-lysyl-[alpha-tubulin] => H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59765", "l": "L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] + octadecanoyl-CoA => CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134800", "l": "STING dimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40730", "l": "1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid <=> a 1-acylglycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67387", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5beta-cholestane-3alpha,7alpha,25-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013009", "l": "RHOA binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18458", "l": "D-ribulose 5-phosphate => (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75411", "l": "demethyllactenocin + S-adenosyl-L-methionine = H(+) + lactenocin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50342", "l": "1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47471", "l": "(2E,4E)-tetradecadienoyl-CoA <=> (3E,5Z)-tetradecadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48914", "l": "CMP + ganglioside GT1a + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391377", "l": "Luteinizing hormone receptor can bind LH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791154", "l": "Expression of GOSR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018506", "l": "maleylacetate reductase activity", "d": ["Catalysis of the reaction: 3-oxoadipate + NAD(P)+ = 2-maleylacetate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22034", "l": "glyoxylate + oxaloacetate => 3-oxalomalate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.274502573267668", "identifiers": [{"i": "GO:0016849", "l": "phosphorus-oxygen lyase activity", "d": ["Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond."]}, {"i": "EC:4.6.-.-", "l": "\"Phosphorus-oxygen lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9817575", "l": "ERO1B oxidizes P4HB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159868", "l": "Furin cleaves pro-factor VII to factor VII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58438", "l": "4-methylpentanal + H(+) + NADPH => 4-methylpentan-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033783", "l": "25-hydroxycholesterol 7alpha-hydroxylase activity", "d": ["Catalysis of the reactions: cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O, and cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047024", "l": "5alpha-androstane-3beta,17beta-diol dehydrogenase activity", "d": ["Catalysis of the reaction: 5alpha-androstane-3beta,17beta-diol + NADP+ = 17beta-hydroxy-5alpha-androstan-3-one + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39017", "l": "docosanedioate + 2 H(+) + NADH => 22-oxodocosanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878679", "l": "Expression of KLF15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12520", "l": "L-dopa = (E)-caffeate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2219524", "l": "PDPK1 binds PIP2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57538", "l": "a 5'-end NTP-ribonucleotide-RNA + AMP + H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + a ribonucleoside 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694401", "l": "E protein gets palmitoylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389026", "l": "Galanin receptors can bind galanin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172666", "l": "RB1 binds condensin II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60091", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) <=> a 4alpha-methyl-3-oxosteroid + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27317", "l": "dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 <=> 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5140741", "l": "WNT5A binds FZD and ROR receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032050", "l": "clathrin heavy chain binding", "d": ["Binding to a clathrin heavy chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64660", "l": "a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28062", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51250", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55792", "l": "butan-2-one + H(+) + NADH + O2 = 1-hydroxy-2-butanone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12038", "l": "3-(imidazol-5-yl)pyruvate + H(+) + NADH => (S)-3-(imidazol-5-yl)lactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39278", "l": "(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH <=> (15Z)-tetracosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047947", "l": "glutamine N-phenylacetyltransferase activity", "d": ["Catalysis of the reaction: phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43052", "l": "3-(methylsulfanyl)propanoate + ATP + CoA = 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.44", "l": "\"3-(methylthio)propionyl--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44396", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5679266", "l": "Beclin-1 complex translocates to the ER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190682", "l": "Connexin synthesis (generic) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190682", "l": "Connexin synthesis (generic) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49228", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) = diphosphate + geranylgeranyl-bacteriochlorophyllide a", "d": []}, {"i": "EC:2.5.1.133", "l": "\"bacteriochlorophyll a synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58103", "l": "1-(15Z-tetracosenoyl)-glycerol + H2O <=> (15Z)-tetracosenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52123", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51082", "l": "19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41349", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54999", "l": "3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6795473", "l": "PDPK1 phosphorylates SGK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65506", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine => [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-921155", "l": "p-STAT5 dissociates from the receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63658", "l": "1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944266", "l": "Association of procollagen type XI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74734", "l": "Re-integration of insulin receptor into plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32689", "l": "diphosphate + tricyclene => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12163", "l": "2-deoxy-D-gluconate + NAD(+) <=> 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769370", "l": "WIF1 binds WNTs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20713", "l": "6-carboxyhexanoyl-CoA + H(+) + L-alanine => (8S)-8-amino-7-oxononanoate + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047329", "l": "phosphoramidate-hexose phosphotransferase activity", "d": ["Catalysis of the reaction: hexose + phosphoramidate = hexose 1-phosphate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0015422", "l": "ABC-type oligosaccharide transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligosaccharide(out) = ADP + phosphate + oligosaccharide(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390641", "l": "ADRA1A,B,D bind ADR,NAd (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48102", "l": "H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => L-arginyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044686", "l": "cysteate synthase activity", "d": ["Catalysis of the reaction: L-phosphoserine + SO32- = L-cysteate + HPO4-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44422", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003856", "l": "3-dehydroquinate synthase activity", "d": ["Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48358", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15927", "l": "bunolol + H(+) + NADPH => dihydrobunolol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:2001062", "l": "xylan binding", "d": ["Binding to xylan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12936", "l": "L-fuculose 1-phosphate <=> (S)-lactaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15464", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41042", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57939", "l": "H2O + isopyridoxal + NAD(+) <=> 5-pyridoxate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102892", "l": "betanidin 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + betanidin <=> H+ + betanin + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13246", "l": "D-threo-isocitrate => glyoxylate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.8.1.8", "l": "\"N-(sulfonatooxy)prop-2-enimidothioate sulfolyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66577", "l": "3'-phosphoadenylyl sulfate + 4-isopropylphenol => 4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28503", "l": "NAD(+) + S-(hydroxymethyl)mycothiol => H(+) + NADH + S-formylmycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629187", "l": "TP53 binds regulatory elements of SESN1,2,3 genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868236", "l": "BAR domain proteins recruit dynamin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74779", "l": "laricitrin + S-adenosyl-L-methionine = 3,3'-O-dimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047567", "l": "3-methyleneoxindole reductase activity", "d": ["Catalysis of the reaction: 3-methyloxindole + NADP+ = 3-methyleneoxindole + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782820", "l": "USP17 deubiquitinates SUDS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.292", "l": "\"(phenol)carboxyphthiodiolenone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15647", "l": "16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate => 16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74978", "l": "a (3R)-3-isocyanyl-fatty acyl-AMP + holo-[ACP] <=> a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58541", "l": "2 L-ascorbate + N-dodecanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1467466", "l": "ABCA4 mediates atRAL transport (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68967", "l": "2-hydroxyoctadecanoate + O2 <=> 2-oxooctadecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23246", "l": "H(+) + norspermidine + S-methyl-5'-thioadenosine => propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008817", "l": "corrinoid adenosyltransferase activity", "d": ["Catalysis of the reaction: 2 ATP + 2 corrinoid + reduced [electron-transfer flavoprotein] = 2 adenosylcorrinoid + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphate. The corrinoid can be cob(II)yrinate a,c diamide, cob(II)inamide or cob(II)alamin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46212", "l": "H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine = 4-amino-5-aminomethyl-2-methylpyrimidine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11184", "l": "3-(carbamoylamino)propanoate + 2 H(+) + H2O = beta-alanine + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799431", "l": "TP53 binds HIPK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51342", "l": "10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961972", "l": "E2F1 binds the RRM2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42322", "l": "a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74580", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein] => N-acetyl-L-cysteine + N-terminal L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190263", "l": "FGFR3b binds to FGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40969", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989753", "l": "Expression of PEX11A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20576", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72992", "l": "2 Na(+)(out) + scyllo-inositol(out) => 2 Na(+)(in) + scyllo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66891", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49520", "l": "2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2 = an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": []}, {"i": "EC:1.14.11.53", "l": "\"mRNA N(6)-methyladenine demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32306", "l": "(2R)-homocitrate <=> (2R,3S)-homoisocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65251", "l": "AH2 + 5 H(+) + 5 malonyl-CoA <=> 6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13387", "l": "2-undecanone + CO2 => 3-oxododecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20585", "l": "loganin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin", "d": []}, {"i": "EC:1.14.19.62", "l": "\"secologanin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51073", "l": "a phenol + an aryl sulfate => a phenol + an aryl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877153", "l": "STARD7 binds PC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72534", "l": "ATP + H2O + methyl beta-D-galactoside(out) <=> ADP + H(+) + methyl beta-D-galactoside(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16606", "l": "dodecanoyl-CoA + H2O + oxaloacetate => (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62510", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30846", "l": "H2O + N-formylmaleamate <=> formate + H(+) + maleamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606288", "l": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69299", "l": "CDT1 binds geminin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166015", "l": "Association of LBP with LPS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33933", "l": "(3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal => all-trans-zeaxanthin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044748", "l": "3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule that contributes to forming distinct miRNA isoforms from a mature miRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39130", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57309", "l": "CTP + H(+) + N(5)-phospho-L-glutamine => diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197958", "l": "FPGS-2 transforms THF to THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27896", "l": "cytidine + phosphate => 3'-CMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42169", "l": "20alpha-hydroxy-5beta-pregnan-3-one + NADP(+) => 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.11", "l": "\"isomaltulose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43405", "l": "N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161662", "l": "PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62248", "l": "chloroacetaldehyde + H2O + NADP(+) = chloroacetate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110307", "l": "REV1 binds AP-dsDNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-688137", "l": "RIP2 is K63 polyubiquitinated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44487", "l": "3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390649", "l": "CHRM1,3,5 bind acetylcholine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71881", "l": "H(+) + N(2)-(ADP-D-ribosyl)-2'-deoxyguanosine + nicotinamide => 2'-deoxyguanosine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33055", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O = diphosphate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102890", "l": "naringenin chalcone 4'-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 2',4,4',6'-tetrahydroxychalcone <=> UDP + 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793837", "l": "TBX6 binds the MESP2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451347", "l": "Activation of JNK by DSCAM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139917", "l": "tBID activates BAX protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5687088", "l": "PKA phosphorylates MAPKAPK5 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64469", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+) => 4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6810376", "l": "ING2 binds PI5P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430347", "l": "MigFilin associates with Filamin and F-actin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374909", "l": "Metabolism of Noradrenaline (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24672", "l": "H(+) + NADH + xanthine => H2O + hypoxanthine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9615348", "l": "AGT(34-41) binds to AGTR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66337", "l": "L-glutamate(out) => L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43647", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32696", "l": "(2E)-geranyl diphosphate => (-)-car-3-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21365", "l": "H2O + N-(6-aminohexanoyl)-6-aminohexanoate => 2 6-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140749", "l": "phlorizin hydrolase activity", "d": ["Catalysis of the reaction: phlorizin + H2O = beta-D-glucose + phloretin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27390", "l": "(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O => pyruvate + salicylaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12145", "l": "cyanidin 3-O-rutinoside + UDP-alpha-D-glucose => cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68614", "l": "NADP(+) + prostaglandin F1 => H(+) + NADPH + prostaglandin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52038", "l": "L-isoleucine + tuberonate => H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809764", "l": "SBF1 binds MTMR2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48603", "l": "[protein-PII]-uridylyl-L-tyrosine + H2O <=> [protein-PII]-L-tyrosine + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53226", "l": "3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27933", "l": "(R)-4-phosphopantoate + ATP + beta-alanine <=> (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615937", "l": "TPNO/KPNB1 (transportin/importin beta) sequester the Nup107-160 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51494", "l": "all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047744", "l": "chloridazon-catechol dioxygenase activity", "d": ["Catalysis of the reaction: 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876446", "l": "p-ULK1 phosphorylates DENND3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453183", "l": "p-Y348-SYK dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62657", "l": "2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate => 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70848", "l": "L-arginine(in) + L-cysteine(out) + Na(+)(out) => L-arginine(out) + L-cysteine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33093", "l": "2-demethylmenaquinol-8 + CO2 + diphosphate => 1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696266", "l": "RND2 binds effectors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40032", "l": "ent-copalyl diphosphate + H2O => diphosphate + ent-manool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54719", "l": "N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444208", "l": "MLNR (GPR38) is a receptor for motilin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954117", "l": "E2F6:TFDP1 binds EPC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66040", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60135", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 <=> a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2327733", "l": "FN1 binds Collagen types I-V, VII (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75510", "l": "n H(+)(out) + taurocholate(out) <=> n H(+)(in) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938930", "l": "RUNX1 binds ELF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72063", "l": "glycoursodeoxycholate(out) + 2 Na(+)(out) = glycoursodeoxycholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045518", "l": "interleukin-22 receptor binding", "d": ["Binding to an interleukin-22 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2059926", "l": "NPHP4 protein binds LATS proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70107", "l": "(S)-5-carboxymethyl-tetronate + o-quinone methide = H(+) + penilactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75856", "l": "Abortive Initiation Before Second Transition (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014449", "l": "RHOG binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43755", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990634", "l": "protein phosphatase 5 binding", "d": ["Binding to protein phosphatase 5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19833", "l": "(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)", "d": []}, {"i": "EC:3.5.1.10", "l": "\"formyltetrahydrofolate deformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72984", "l": "dimethylallyl diphosphate + harmol => 6-(3-dimethylallyl)harmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59313", "l": "D-galactose + O2 => D-galactono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807872", "l": "Active ARF recruits coatomer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29684", "l": "alpha-maltohexaose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltopentaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47583", "l": "ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GT2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689111", "l": "PARK2 autoubiquitinates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63239", "l": "ATP + streptomycin <=> 6-O-adenylylstreptomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25066", "l": "(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62328", "l": "(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) = (+)-malbrancheamide + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44250", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-350901", "l": "Iodide is organified (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813626", "l": "LEAP2 binds bacteria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023592", "l": "MECP2 binds HTT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25865", "l": "H2O + N(1)-acetylspermidine + O2 => 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69638", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71864", "l": "taurodeoxycholate(out) => taurodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21199", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine <=> L-methionine + tetrahydropteroyltri-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202713", "l": "CD84 homodimerises (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39461", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+) => (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56026", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602484", "l": "Activation of proMMP11 by FURIN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48994", "l": "1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+) => 1,3,7-trimethylurate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74962", "l": "(3R)-3-isocyanylbutanoate + ATP + holo-[ACP] <=> (3R)-3-isocyanylbutanoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10131", "l": "all-trans-violaxanthin <=> all-trans-neoxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74896", "l": "nitric oxide(out) => nitric oxide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696960", "l": "USP49 deubiquitinates H2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433506", "l": "Phosphorylation of APS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34561", "l": "1-deoxy-11-oxopentalenate + H(+) + NADH => 1-deoxy-11beta-hydroxypentalenate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177930", "l": "GAB1 phosphorylation by EGFR kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47251", "l": "2 Fe(III)-[cytochrome c] + L-gulono-1,4-lactone <=> 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977371", "l": "Factor I inactivates Factor H-boundC3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848758", "l": "PTK6 phosphorylates AKT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9017491", "l": "RHOJ GEFs activate RHOJ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25265", "l": "2-phenylethylamine + H2O + O2 = 2-phenylacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199014", "l": "CD96 binds PVR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67990", "l": "N-acetyl-D-glutamine => N-acetyl-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19857", "l": "a 16alpha-hydroxysteroid + NADP(+) = a 16-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247922", "l": "GGCT transforms gGluCys to OPRO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.207", "l": "\"tRNA (cytidine(34)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009882", "l": "blue light photoreceptor activity", "d": ["The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35772", "l": "5-deoxy-5-amino-3-dehydroshikimate => 3-amino-5-hydroxybenzoate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14004", "l": "choloyl-CoA + glycine <=> CoA + glycocholate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112385", "l": "Addition of nucleotides leads to transcript elongation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71462", "l": "H2O + substance P <=> L-Leu-L-Met-NH2 + substance P(1-9)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199929", "l": "ERK5 activates the transcription factor MEF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40937", "l": "1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+) => a 1-acylglycerone 3-phosphate + hexadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109639", "l": "Formation of the closed pre-initiation complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57471", "l": "(E)-ferulate + UDP-alpha-D-glucose <=> 1-O-[(E)-feruloyl]-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507873", "l": "Aquaporins passively transport urea out of cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102277", "l": "2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose exo-beta-D-glucosaminidase activity", "d": ["Catalysis of the reaction: 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose + H2O = N-acetyl-D-glucosamine + D-glucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9035227", "l": "TXN2 binds CysS248-MPST (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852324", "l": "GTSE1 binds PLK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75898", "l": "holothin + marinoloyl-CoA C <=> CoA + thiomarinol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11219", "l": "a 2'-deoxyribonucleoside 5'-phosphate + ATP <=> a 2'-deoxyribonucleoside 5'-diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800035", "l": "IGFBP3 binds TMEM219 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673284", "l": "GTP-bound RAC1 contributes to MAPK8 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854209", "l": "TBC1D10A binds JFC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71117", "l": "3-hydroxyhispidin + H2O + NAD(+) => H(+) + hispidin + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38791", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29600", "l": "monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45658", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047609", "l": "acetylputrescine deacetylase activity", "d": ["Catalysis of the reaction: N-acetylputrescine + H2O = acetate + putrescine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072590", "l": "N-acetyl-L-aspartate-L-glutamate ligase activity", "d": ["Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate."]}, {"i": "REACT:R-HSA-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093331", "l": "Ras:GTP binds p120-RasGAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088281", "l": "Endorepellin binds KDR (VEGFR2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52827", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 <=> (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49743", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate <=> CO2 + deoxyviolacein + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17417", "l": "ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}, {"i": "EC:2.7.1.59", "l": "\"N-acetylglucosamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43562", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662608", "l": "MT2A binds cadmium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47928", "l": "(2S)-3-sulfolactaldehyde + H2O + NADP(+) = (2S)-3-sulfolactate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40319", "l": "O2 + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003786", "l": "actin lateral binding", "d": ["Binding to an actin filament along its length."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865605", "l": "BRWD1 binds SMARCA4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31819", "l": "(2E,6E)-farnesyl diphosphate = 5-epi-alpha-selinene + diphosphate", "d": []}, {"i": "EC:4.2.3.90", "l": "\"5-epi-alpha-selinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641229", "l": "TLE oligomerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48294", "l": "ganglioside Fuc-GM1 + GDP + H(+) => ganglioside GM1 + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73137", "l": "4',7-dihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 4',7,8-trihydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418904", "l": "A1 and A3 receptors bind adenosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665871", "l": "ADRM1 binds 26S proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655343", "l": "Activated FGFR2 mutants bind PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15674", "l": "acetoacetyl-CoA + H2O => acetoacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29451", "l": "H2O + phosphonate = H2 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442725", "l": "CaMKII binds activated calmodulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942302", "l": "MMP13 cleaves OPTC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429767", "l": "Passive I- efflux mediated by SMCT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57884", "l": "diphosphate + H2O + Na(+)(in) = H(+) + Na(+)(out) + 2 phosphate", "d": []}, {"i": "EC:7.2.3.1", "l": "\"Na(+)-exporting diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2562526", "l": "PLK1 phosphorylates OPTN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75975", "l": "(S)-stylopine + S-adenosyl-L-methionine = (S)-cis-N-methylstylopine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008449", "l": "N-acetylglucosamine-6-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23713", "l": "NADP(+) + pregnan-21-ol => H(+) + NADPH + pregnan-21-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32075", "l": "geranylgeranyl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate", "d": []}, {"i": "EC:3.1.7.10", "l": "\"(13E)-labda-7,13-dien-15-ol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985591", "l": "SLIT2-bound ROBO1 binds MYO9B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654404", "l": "Activated FGFR2 binds SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20724", "l": "a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25215", "l": "2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP => H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40464", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55675", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213244", "l": "Loading of antigenic peptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68183", "l": "a short-chain fatty acyl-CoA + H2O <=> a short-chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.-", "l": "\"Serine endopeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050387", "l": "urethanase activity", "d": ["Catalysis of the reaction: H2O + H+ + urethane = CO2 + ethanol + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33215", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23733", "l": "(R)-5-diphosphomevalonate + ATP => ADP + CO2 + isopentenyl diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70308", "l": "beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18931", "l": "5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O => AH2 + O2 + thiophene-2-carbonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37733", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28478", "l": "galactarate(in) + H(+)(in) = galactarate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693012", "l": "TNFSF15 binds TNFRSF25 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015653", "l": "glycine betaine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43278", "l": "ganglioside GalNAc-GD1a + H(+) + UDP => ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32871", "l": "a 2-acylglycerol + H2O = a carboxylate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74239", "l": "phosphate + solabiose = alpha-D-glucose 1-phosphate + D-galactose", "d": []}, {"i": "EC:2.4.1.389", "l": "\"solabiose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.240853996207278", "identifiers": [{"i": "GO:0016881", "l": "acid-amino acid ligase activity", "d": ["Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}, {"i": "EC:6.3.2.-", "l": "\"Acid--amino-acid ligases (peptide synthases)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442749", "l": "CaMKK autophosphorylates in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167468", "l": "Abortive HIV-1 Initiation After Second Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047344", "l": "glucose-1-phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + GTP = diphosphate + GDP-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15973", "l": "3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+)", "d": []}, {"i": "EC:2.8.2.4", "l": "\"estrone sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52597", "l": "lithocholoyl-CoA + NAD(+) => 3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42982", "l": "2-aminoprop-2-enoate + phenol => L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39666", "l": "a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75978", "l": "(S)-stylopine + S-adenosyl-L-methionine <=> (S)-cis-N-methylstylopine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55279", "l": "9-cis-retinol + tetradecanoyl-CoA <=> 9-cis-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62485", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-571316", "l": "Autophosphorylation of IRAK4 bound to the activated TLR7 or 21complex.  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18642", "l": "a menaquinone + H2 => a menaquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696465", "l": "USP45 deubiquitinates ERCC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102390", "l": "mycophenolic acid acyl-glucuronide esterase activity", "d": ["Catalysis of the reaction: mycophenolic acid O-acyl-glucuronide(1-) + H2O <=> mycophenolate + H+ + D-glucopyranuronate."]}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0140784", "l": "metal ion sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of a metal ion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10214", "l": "5-oxopentanoate + L-glutamate => 2-oxoglutarate + 5-aminopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25563", "l": "9alpha-copalyl diphosphate <=> 9beta-pimara-7,15-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21099", "l": "3-dehydroquinate <=> 3-dehydroshikimate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61295", "l": "(R)-pantoate + NAD(+) <=> 2-dehydropantoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102135", "l": "(22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity", "d": ["Catalysis of the reaction: H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH + O2 <=> (22R,23R)-22,23-dihydroxy-campest-4-en-3-one + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34678", "l": "CTP + N,N-diacetyllegionaminate <=> CMP-N,N-diacetyllegionaminate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23694", "l": "H2O + maleate => (R)-malate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10894", "l": "(2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH => (2R,3S)-3-isopropylmalate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60364", "l": "H(+)(out) + myo-inositol(out) = H(+)(in) + myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53733", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate => 2-hydroxy-7,8-dihydropteroate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29442", "l": "Fe(2+)(in) + H(+)(out) <=> Fe(2+)(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726875", "l": "HCNs:cAMP bind SNIs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12546", "l": "2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate => 2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983156", "l": "Polyubiquitination of substrate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28455", "l": "N(6)-(D-fructosyl)-L-lysine(in) => N(6)-(D-fructosyl)-L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62242", "l": "a thymine-cytidine dinucleotide in DNA => a thymidine(6-4)cytidine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36581", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH => dTDP-alpha-D-fucose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9761027", "l": "ZEB2 binds SP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22452", "l": "[phosphate](n+1) + n H2O = n H(+) + (n+1) phosphate", "d": []}, {"i": "EC:3.6.1.10", "l": "\"endopolyphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20536", "l": "H2O + pyridoxal 5'-phosphate <=> phosphate + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69371", "l": "11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+) <=> 17beta-hydroxyandrost-4-ene-3,11-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55308", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390912", "l": "HRH1 binds hist (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0044013", "l": "histone H2B acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine = CoA + histone H2B N6-acetyl-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002135", "l": "CTP binding", "d": ["Binding to CTP, cytidine 5'-triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44537", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29852", "l": "H2O + UDP-N-acetyl-alpha-D-galactosamine => 2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45640", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614605", "l": "Persulfide sulfur is dioxygenated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44456", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420265", "l": "AMY1-3 bind IAPP(34-70) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29290", "l": "2 H(+)(in) + L-aspartate(in) <=> 2 H(+)(out) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40519", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0070061", "l": "fructose binding", "d": ["Binding to the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59998", "l": "(E)-cinnamate + reduced [electron-transfer flavoprotein] => 3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63695", "l": "alcohol glucuronate acceptor + UDP-alpha-D-glucuronate <=> a beta-D-glucuronoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949580", "l": "F1Fo ATP synthase dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708275", "l": "PDE4A binds PDE4A inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59917", "l": "(2E)-octenal + H2O + NADP(+) => (2E)-octenoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65136", "l": "(9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50987", "l": "prostaglandin E2(out) <=> prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59410", "l": "acetate + L-aspartate => H2O + N-acetyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2545203", "l": "Deacetylation of cleaved cohesin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60609", "l": "1-tetradecanoyl-sn-glycero-3-phosphoethanolamine => 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59575", "l": "H2O + L-homocarnosine <=> 4-aminobutanoate + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429992", "l": "PARN deadenylates mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707690", "l": "BACH1 binds MAFK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69555", "l": "dihydroxyacetone phosphate + L-glutamate <=> (S)-serinol phosphate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55462", "l": "11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54885", "l": "L-arginyl-[protein] + NADP(+) => H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102863", "l": "1-18:3-2-18:1-phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443779", "l": "Linkage of L1 with treadmilling F-actin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38926", "l": "a ubiquinone + H(+) + Na(+)(in) + NADH <=> a ubiquinol + Na(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129357", "l": "Fibrillin C-terminal processing (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419644", "l": "Transphosphorylation of pLIMK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783670", "l": "CRLF1 binds CLCF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102691", "l": "UDP-glucose:benzyladenine 7-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine <=> H+ + benzyladenine-7-N-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.111", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507870", "l": "Aquaporins passively transport water out of cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626681", "l": "Recruitment of transition zone proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879594", "l": "SLCO4C1 mediates the transport of digoxin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11700", "l": "H(+) + NADPH + O2 + progesterone = H2O + NADP(+) + testosterone acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50886", "l": "(9Z-octadecenoyl)-glycerol + phosphate => (9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399711", "l": "Activation of Ca impermeable AMPA receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612514", "l": "p-S133 CREB and p-S103 SRF bind the EGR1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47295", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814695", "l": "PERP binds desmosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39951", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46403", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42335", "l": "ATP + L-glutamate + oxidized coenzyme F420-2 <=> ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73788", "l": "dimethylallyl diphosphate + tardioxopiperazine A => diphosphate + variecolorin L", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034791", "l": "isobutylamine N-hydroxylase activity", "d": ["Catalysis of the reaction: isobutylamine + NADPH + O2 = isobutylhydroxylamine + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38207", "l": "19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9654533", "l": "KRAS4B recycles to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49469", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose => a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53564", "l": "9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2396399", "l": "Fibrillins bind BMPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54165", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75559", "l": "erinacol + O2 + reduced [NADPH--hemoprotein reductase] = cyathadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140952", "l": "histone H3K27 dimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl27-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl27-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me2."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015658", "l": "branched-chain amino acid transmembrane transporter activity", "d": ["Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings."]}, {"i": "REACT:R-HSA-9672770", "l": "SLC25A44 transports Leu, Ile and Val from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19218", "l": "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane => 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62134", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + dTDP => a 2'-deoxyribonucleoside 5'-phosphate + dTTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.-", "l": "\"Endoribonucleases producing other than 5'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12020", "l": "a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49557", "l": "H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] => H(+) + L-cysteinyl-[protein] + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36986", "l": "(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63068", "l": "acetyl-CoA + 2 H(+) + 2 malonyl-CoA = 2 CO2 + 3 CoA + triacetate lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047221", "l": "sn-glycerol-3-phosphate 2-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65294", "l": "3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate => 2 ATP + butan-2-one + 3 H2O + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483186", "l": "PC is converted to PS by PTDSS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62856", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40433", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27995", "l": "H2O + xanthosine => D-ribose + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50080", "l": "ATP + H2O + taurodeoxycholate(in) = ADP + H(+) + phosphate + taurodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002460", "l": "P4HB binds Collagen chains (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730903", "l": "Oligomerization of TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59378", "l": "4-amino-4-deoxyprephenate => 4-amino-4-deoxychorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43248", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O = 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40431", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69640", "l": "H2O + phlorizin => beta-D-glucose + phloretin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33383", "l": "(S)-malate + UDP-N-acetyl-alpha-D-glucosamine = (S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21753", "l": "all-trans-violaxanthin => all-trans-capsorubin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41351", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72621", "l": "Ribosomal scanning  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56932", "l": "androst-5-en-3beta,17beta-diol + NAD(+) = 17beta-hydroxy-androst-5-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445699", "l": "ATP Hydrolysis By Myosin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098627", "l": "protein arginine phosphatase activity", "d": ["Catalysis of the reaction: protein arginine phosphate + H2O = protein arginine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39735", "l": "3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52455", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate <=> 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70278", "l": "H2O + raffinose <=> D-galactose + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-500708", "l": "GRIK3 homomer binds glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54070", "l": "diphosphate + sesterfisherol => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27773", "l": "3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853762", "l": "RET dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33920", "l": "H(+) + lanosterol + NADPH => 24,25-dihydrolanosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710959", "l": "p-STAT1 dimer binds KPNA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3364014", "l": "Recruitment of SET1 methyltransferase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22899", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH <=> a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140474", "l": "mitochondrion-endoplasmic reticulum membrane tether activity", "d": ["The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16765", "l": "D-mannitol + NADP(+) = D-fructose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.138", "l": "\"mannitol 2-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5229283", "l": "LCNs bind lipids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40311", "l": "hexanoyl-CoA + O2 = (2E)-hexenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690494", "l": "RHOB translocates to the endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212222", "l": "PRC2 recruits DNA methyltransferases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62536", "l": "digoxigenin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydrodigoxigenin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56984", "l": "(2E,6E)-farnesyl diphosphate + H2O = (6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0061731", "l": "ribonucleoside-diphosphate reductase activity", "d": ["Catalysis of the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694527", "l": "Loss of SAR1B GTPase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47298", "l": "(2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein] => dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102248", "l": "diacylglycerol transacylase activity", "d": ["Catalysis of the reaction: 2 a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + a 2-monoglyceride."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72072", "l": "L-histidyl-[protein] + NAD(+) => H(+) + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2399913", "l": "atRAL binds to RBP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.876036511014462", "identifiers": [{"i": "GO:0008483", "l": "transaminase activity", "d": ["Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560785", "l": "Defective PAPSS2 does not transfer PO4(2-) group from ATP to APS to form PAPS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44271", "l": "3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49115", "l": "phenazine-1-carboxylate + S-adenosyl-L-methionine <=> 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140978", "l": "mitochondrial large ribosomal subunit binding", "d": ["Binding to a mitochondrial large ribosomal subunit."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102895", "l": "colneleate synthase activity", "d": ["Catalysis of the reaction: 9(S)-HPODE <=> colneleate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27381", "l": "(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate", "d": []}, {"i": "EC:3.1.3.80", "l": "\"2,3-bisphosphoglycerate 3-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50850", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050029", "l": "L-lysine oxidase activity", "d": ["Catalysis of the reaction: L-lysine + H2O + O2 = 6-amino-2-oxohexanoate + H2O2 + NH4."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0000171", "l": "ribonuclease MRP activity", "d": ["Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12760", "l": "dihydrozeatin + NADP(+) <=> H(+) + NADPH + zeatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717841", "l": "holo-FDPS dimer binds NBPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624976", "l": "FOXO1,FOXO3 binds CAV1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005366", "l": "myo-inositol:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10995", "l": "glycolate + NADP(+) <=> glyoxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20787", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginine <=> ADP-D-ribose + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41072", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873921", "l": "Binding of STAT1 to p-IFNGR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380508", "l": "Translocation of NuMA to the centrosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74019", "l": "glycine(out) + L-alanine(in) = glycine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29525", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+) => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32672", "l": "ATP + UDP-N-acetyl-alpha-D-glucosamine => ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986943", "l": "MECP2 binds MET gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30783", "l": "D-glyceraldehyde + H2O + NAD(+) = (R)-glycerate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29086", "l": "(S)-malate + ubiquinone-8 <=> oxaloacetate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37023", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008043", "l": "MAPK8 phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046406", "l": "magnesium protoporphyrin IX methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + magnesium protoporphyrin IX = S-adenosyl-L-homocysteine + H+ + magnesium protoporphyrin IX 13-monomethyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013021", "l": "GDIs block activation of RHOB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694442", "l": "CNIH2,3 bind GRIA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43832", "l": "5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA = 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102035", "l": "isobutyryl-CoA:FAD oxidoreductase activity", "d": ["Catalysis of the reaction: H+ + isobutyryl-CoA + FAD <=> methacrylyl-CoA + FADH2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692749", "l": "CDC14A,B bind MAPK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67333", "l": "13-cis-retinal + H2O + NAD(+) => 13-cis-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.22", "l": "\"metallocarboxypeptidase D\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080109", "l": "indole-3-acetonitrile nitrile hydratase activity", "d": ["Catalysis of the reaction: indole-3-acetonitrile + H2O = indole-3-acetamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388808", "l": "CD28 homodimer binds B7-2 monomer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52564", "l": "2-dehydro-L-erythronate = 3-dehydro-L-erythronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36116", "l": "gibberellin A3 + S-adenosyl-L-methionine => O-methyl gibberellin A3 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019115", "l": "benzaldehyde dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49898", "l": "5,10-dihydrophenazine-1,6-dicarboxylate => (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70109", "l": "H(+) + penilactone D => (S)-5-carboxymethyl-tetronate + o-quinone methide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5138432", "l": "DVL2 is phosphorylated by PKC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0004365", "l": "glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0005024", "l": "transforming growth factor beta receptor activity", "d": ["Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73060", "l": "Ca(2+)(in) + Mn(2+)(out) => Ca(2+)(out) + Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186765", "l": "PLC-gamma binds to the active receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40418", "l": "H2O + pristanoyl-CoA <=> 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55577", "l": "4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine => H(+) + psilocybin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007901", "l": "IL1F10 binds IL1RL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693356", "l": "CEMIP hydrolyses HA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42025", "l": "3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) => 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36589", "l": "aldono-1,5-lactone + H(+) + NADPH => an aldopyranose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849094", "l": "ARHGAP35 binds RASA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28991", "l": "N-acetylneuraminate(in) = N-acetylneuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10199", "l": "(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate <=> 2-succinylbenzoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5660665", "l": "Caspase-8 binds MALT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66092", "l": "3-phenylpyruvate + L-kynurenine = H2O + kynurenate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205244", "l": "Recruitment of CBL to KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21451", "l": "16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] <=> 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985153", "l": "OASL binds DDX58 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39351", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA = (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22622", "l": "3-indoleglycolaldehyde + CO2 + NH4(+) => H(+) + L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55838", "l": "calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP => calcitriol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60772", "l": "2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2 = 3 CO2 + gibberellin A9 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9669854", "l": "KIT binds type II TKIs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350396", "l": "DSH binds to DAAM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52965", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate => H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43526", "l": "aminoacetone + CO2 + NADPH => L-allo-threonine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809309", "l": "MTMR6 binds MTMR9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40332", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP => 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10913", "l": "(R)-pantoate + ATP + beta-alanine => (R)-pantothenate + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58430", "l": "(E,E)-2,4-hexadienal + H(+) + NADPH => (E,E)-2,4-hexadien-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67230", "l": "(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O => (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617182", "l": "PRKACA phosphorylates PLN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72252", "l": "(R)-adrenaline + S-adenosyl-L-methionine => (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45767", "l": "H2O + L-aspartate 4-semialdehyde + NAD(+) <=> 2 H(+) + L-aspartate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005161", "l": "platelet-derived growth factor receptor binding", "d": ["Binding to a platelet-derived growth factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31156", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) => (4S)-4-hydroxy-L-glutamate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65039", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13403", "l": "(2Z,6E)-farnesol => (2E,6E)-farnesol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43161", "l": "adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2429719", "l": "MCPH1 sequesters condensin II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45217", "l": "coenzyme M + methyl-Co(III)-[dimethylamine-specific corrinoid protein] => Co(I)-[dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66492", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42400", "l": "lactose(out) + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + lactose 6-phosphate(in)", "d": []}, {"i": "EC:2.7.1.207", "l": "\"protein-N(pi)-phosphohistidine--lactose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30958", "l": "9,9'-di-cis-zeta-carotene + 2 a quinone <=> 7,7',9,9'-tetra-cis-lycopene + 2 a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56738", "l": "H(+) + H2O2 + retinoate => H2O + O2 + retinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49753", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate => CO2 + 2 H2O + NAD(+) + proviolacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21401", "l": "2-oxoglutarate + CoA + NADP(+) => CO2 + NADPH + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54513", "l": "peregrinol diphosphate => (13R)-9,13-epoxylabd-14-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201630", "l": "Caspase-mediated cleavage of Acinus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295613", "l": "SPRY2 binds GRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645766", "l": "p14ARF mutants do not bind C1QBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23472", "l": "2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose", "d": []}, {"i": "EC:2.3.1.122", "l": "\"trehalose O-mycolyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008871", "l": "aminoglycoside 2''-nucleotidyltransferase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74791", "l": "(R)-salsolinol(in) = (R)-salsolinol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20644", "l": "H2O + L-histidinol + 2 NAD(+) <=> 3 H(+) + L-histidine + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61307", "l": "N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose <=> H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65355", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.66", "l": "\"beta-selinene cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.280", "l": "\"(aminoalkyl)phosphonate N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391933", "l": "EP3 receptor can bind PGE2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46181", "l": "2-methylbutanoate + ATP + CoA => 2-methylbutanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39913", "l": "(3S)-2-oxo-3-phenylbutanoate + L-glutamate => (2S,3S)-3-methylphenylalanine + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216045", "l": "Collagen type I binds integrin alpha11beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66822", "l": "ADP + H(+) + Mn(2+)(out) + phosphate => ATP + H2O + Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39737", "l": "3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030622", "l": "U4atac snRNA binding", "d": ["Binding to a U4atac small nuclear RNA (U4atac snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25438", "l": "(E,R)-alpha-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25498", "l": "(1S,5S)-beta-pinene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730847", "l": "Hydrolysis of PIP2 by PLCG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042926", "l": "3-hydroxyphenylpropionic acid transmembrane transporter activity", "d": ["Enables the directed movement of 3-hydroxyphenylpropionic acid from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052910", "l": "23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099077", "l": "histone-dependent DNA binding", "d": ["DNA-binding activity that is dependent on binding to a histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39851", "l": "2 a 1-acyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22668", "l": "2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = H(+) + lipid A disaccharide (E. coli) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50780", "l": "NADP(+) + octanal = (2E)-octenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23272", "l": "an N(6)-alkylaminopurine + UDP-alpha-D-glucose = an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.118", "l": "\"cytokinin 7-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16807", "l": "CO2 + deacetylcephalosporin C + succinate => 2-oxoglutarate + deacetoxycephalosporin C + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33372", "l": "alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] => alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870469", "l": "RGGT geranylgeranylates RAB proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58672", "l": "D-glucuronate = aldehydo-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17641", "l": "H(+) + L-arginine = agmatine + CO2", "d": []}, {"i": "EC:4.1.1.19", "l": "\"arginine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22810", "l": "2,6-dihydroxynicotinate + H2O2 => 6-hydroxynicotinate + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24398", "l": "1,3,8-trihydroxynaphthalene + H2O => scytalone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56858", "l": "a carboxylate + AH2 + H(+) => A + an aldehyde + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165162", "l": "Phosphorylation of TSC2 by PKB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110360", "l": "Recruitment of POLB to the AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423728", "l": "AFXBO translocates from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51949", "l": "(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205286", "l": "GRB2:SOS interacts with p-KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420980", "l": "Activation of Ca permeable AMPA receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72103", "l": "Formation of pre-mRNPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.25", "l": "\"mugineic-acid 3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73577", "l": "CAD hexamer transforms L-Gln to CAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-166214", "l": "FA anion flip-flops to the opposite surface (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797763", "l": "TP53 inhibits BIRC5 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11355", "l": "acetate + ATP <=> acetyl phosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209179", "l": "IAP2:BEN:UEV1A E3 ligase complex auto-ubiquitinates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204779", "l": "Interaction of Tie2 with Ang1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13792", "l": "[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373720", "l": "FADK1 interaction with DCC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77068", "l": "Activation of GT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29253", "l": "2 H(+)(in) + Na(+)(out) => 2 H(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64539", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73596", "l": "dCMP + H2O => dUMP + NH4+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692408", "l": "NPR2 binds NPPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34997", "l": "L-rhamnose(out) => L-rhamnose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70985", "l": "glycine(in) + n H(+)(out) => glycine(out) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65158", "l": "CO2 + H2O + preaustinoid A3 + succinate => 2-oxoglutarate + O2 + preaustinoid A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19257", "l": "a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36214", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-532630", "l": "p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433415", "l": "Activation of RAC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61504", "l": "pelargonidin + UDP-alpha-D-glucose = pelargonidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61677", "l": "holo-[peptidyl-carrier protein] + L-cysteinyl-5'-AMP => AMP + H(+) + L-cysteinyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70803", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate = 4-deoxy-4-sulfo-D-erythrose + D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222469", "l": "SodC reduces superoxide to H2O2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009072", "l": "STAT3 phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41667", "l": "dihydrochelirubine + NAD(+) <=> chelirubine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070181", "l": "small ribosomal subunit rRNA binding", "d": ["Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679266", "l": "Beclin-1 complex translocates to the ER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928645", "l": "EPHB:NMDAR binds TIAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42995", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (R)-nephthenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22014", "l": "precorrin-5 + S-adenosyl-L-homocysteine => precorrin-4 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954082", "l": "E2F6 binds the PRC1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54340", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67946", "l": "2-oxohexadecanoate + H2O2 => 2-hydroxyhexadecanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62324", "l": "(+)-malbrancheamide B + chloride + FAD + 2 H(+) = (+)-malbrancheamide + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013145", "l": "RAC1 binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237119", "l": "Acireductone is oxidized to MOB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17942", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate => 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13309", "l": "H2O + NAD(+) + vanillin = 2 H(+) + NADH + vanillate", "d": []}, {"i": "EC:1.2.1.67", "l": "\"vanillin dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33883", "l": "2-deoxy-scyllo-inosamine + NAD(+) = 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50891", "l": "an N-acylsphingoid base 1-phosphate + H2O <=> an N-acyl-sphingoid base + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0045159", "l": "myosin II binding", "d": ["Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55004", "l": "1-hydroxylimonen-2-one + NADPH + O2 = 3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48132", "l": "(2E,6E)-farnesyl phosphate + H2O = (2E,6E)-farnesol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12448", "l": "(R)-pantothenate + H2O = (R)-pantoate + beta-alanine", "d": []}, {"i": "EC:3.5.1.22", "l": "\"pantothenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49686", "l": "benzene-1,2,4-triol + H2O + NAD(+) => H(+) + NADH + O2 + resorcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47693", "l": "AH2 + neomycin C + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24338", "l": "AMP + an acyl-CoA + diphosphate => a carboxylate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30240", "l": "n a quinone + n H(+) + n hydrogen sulfide => n a quinol + n sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34161", "l": "CoA + H(+) + UDP-N,N'-diacetylbacillosamine => acetyl-CoA + UDP-N-acetylbacillosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-350769", "l": "trans-Golgi Network Coat Activation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195304", "l": "Association of beta-catenin with the destruction complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44054", "l": "2-O-hexadecanoyl-alpha,alpha-trehalose + CoA => alpha,alpha-trehalose + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696482", "l": "CTF1 binds LIFR:JAKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451310", "l": "Activation of Edited Kainate receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13042", "l": "L-dopachrome => 5,6-dihydroxyindole-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47510", "l": "isolithocholate + NAD(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158399", "l": "kallikrein binds SERPING1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810392", "l": "TMEM55B translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75193", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH => 2-dehydro-3-deoxy-L-fuconate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417825", "l": "P2Y11 receptor can bind to ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373145", "l": "fumarate + H2O <=> malate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912366", "l": "MIR206 microRNA binds 3'UTR of NOTCH3 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68002", "l": "A + chloride + chloroethene + H(+) => 1,1-dichloroethene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62399", "l": "(1S,2S)-pseudoephedrine + NAD(+) <=> (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46097", "l": "3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4 CO2 + 4 CoA + dihydropinosylvin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675473", "l": "SH2B binds JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34252", "l": "1-deoxysphinganine + NADP(+) => 1-deoxy-3-dehydrosphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46625", "l": "a D-5-monosubstituted hydantoin => a L-5-monosubstituted hydantoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22383", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O <=> [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66388", "l": "ATP + H2O + prostaglandin E2(in) = ADP + H(+) + phosphate + prostaglandin E2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033758", "l": "clavaminate synthase activity", "d": ["Catalysis of the reactions: deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 + H2O; proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + 2 H2O; and dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25113", "l": "H2O + pyridoxine 5'-phosphate => phosphate + pyridoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39630", "l": "(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA <=> (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662986", "l": "MT2A binds copper (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20142", "l": "an S-alkyl-L-cysteine S-oxide => 2-aminoprop-2-enoate + an S-alkyl sulfenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112396", "l": "Separation of elongating transcript from template (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112055", "l": "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001691", "l": "pseudophosphatase activity", "d": ["Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373342", "l": "CX3CR1 binds CX3CL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031895", "l": "V1B vasopressin receptor binding", "d": ["Binding to a V1B vasopressin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37270", "l": "H2O + L-alanyl-L-aspartate <=> L-alanine + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690702", "l": "LYN phosphorylates CD22 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75952", "l": "2-oxoglutarate + O2 + oripavine => CO2 + formaldehyde + neomorphinone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42315", "l": "H(+) + NADP(+) + 2 reduced [adrenodoxin] <=> NADPH + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004125", "l": "L-seryl-tRNA(Sec) selenium transferase activity", "d": ["Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623643", "l": "RDH13 reduces atRAL to atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47882", "l": "H(+) + octanoate + octanoylglycerol => dioctanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9794008", "l": "LUBAC binds CFLAR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8941895", "l": "Formation of CDK4/6:CCND complexes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32281", "l": "(S)-ureidoglycolate + CO2 + 2 NH4(+) => allantoate + 2 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28026", "l": "[thioredoxin]-disulfide + dUDP + H2O = [thioredoxin]-dithiol + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67393", "l": "2-oxo-ATP + H2O => 2-oxo-AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848930", "l": "PTK6 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15044", "l": "bis-D-fructose 2',1:2,1'-dianhydride + H2O <=> inulobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050345", "l": "trans-epoxysuccinate hydrolase activity", "d": ["Catalysis of the reaction: trans-2,3-epoxysuccinate + H2O = (2R,3S)-tartrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47908", "l": "6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O = 6-deoxy-6-sulfo-D-gluconate + H(+)", "d": []}, {"i": "EC:3.1.1.99", "l": "\"6-deoxy-6-sulfogluconolactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69526", "l": "D-glucose + H2O2 => D-sorbitol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080031", "l": "methyl salicylate esterase activity", "d": ["Catalysis of the reaction: methyl salicylate + H2O = salicylic acid + methanol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14895", "l": "(2R,4S)-2,4-diaminopentanoate => D-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65159", "l": "2-oxoglutarate + O2 + preaustinoid A2 <=> CO2 + H2O + preaustinoid A3 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31471", "l": "beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose = beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31483", "l": "soyasapogenol E + UDP-alpha-D-glucuronate = H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16090", "l": "H2O + phosphoethanolamine => ethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74493", "l": "yaequinolone D => [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215406", "l": "PRMT5 binds WDR77 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15380", "l": "(S)-4,5-dihydroxypentane-2,3-dione + ATP <=> (2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60083", "l": "4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 <=> 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45710", "l": "3-dehydrocarnityl-CoA + acetate => 3-dehydrocarnitine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41250", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047282", "l": "dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity", "d": ["Catalysis of the reaction: dTDP-L-dihydrostreptose + streptidine 6-phosphate = O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate + dTDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646468", "l": "mTORC1 binds RHEB:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850831", "l": "KLK5 cleaves and activates KLK8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55891", "l": "[aequorin]--dioxetanone <=> [excited state blue fluorescent protein] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944236", "l": "Association of procollagen type XIV (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75086", "l": "32-oxo-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24629", "l": "2 H2O + 3 NAD(+) + NH4(+) => 5 H(+) + 3 NADH + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801776", "l": "REG3A binds bacterial phospholipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71095", "l": "2 Na(+)(out) + pregnenolone sulfate(out) = 2 Na(+)(in) + pregnenolone sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24332", "l": "3alpha-hydroxy-3,5-dihydromonacolin L carboxylate = H2O + monacolin L carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37009", "l": "3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23517", "l": "(R)-glycerate + ATP => (2R)-3-phosphoglycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20346", "l": "[thioredoxin]-dithiol + NADP(+) => [thioredoxin]-disulfide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004603", "l": "phenylethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45350", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58152", "l": "H2O + NAD(+) + phosphonoacetaldehyde = 2 H(+) + NADH + phosphonoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72496", "l": "glutarate(in) + prostaglandin E2(out) => glutarate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797090", "l": "CCNK binds CDK12 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35241", "l": "tetracycline(out) => tetracycline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17998", "l": "Co-precorrin-2 + S-adenosyl-L-methionine => Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1006143", "l": "CD46 binds C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30480", "l": "L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40243", "l": "(3R)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247839", "l": "Retromer associates with WLS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42805", "l": "5,6,7,8-tetrahydromethanopterin + A => 7,8-dihydromethanopterin + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035274", "l": "diphenyl phthalate binding", "d": ["Binding to diphenyl phthalate, C(20)H(14)O(4)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72595", "l": "H(+)(out) + N-acetyl-L-aspartyl-L-glutamate(out) = H(+)(in) + N-acetyl-L-aspartyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938887", "l": "PML binds RUNX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32702", "l": "(2E,6E)-farnesyl diphosphate <=> beta-sesquiphellandrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351207", "l": "Spermine  => N-acetylated spermine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16418", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) => H(+) + L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197963", "l": "DHFR2 reduces FOLA to DHF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112436", "l": "Formation of Elongin complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24457", "l": "alpha-ribazole 5'-phosphate + H2O => alpha-ribazole + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426223", "l": "Cation influx mediated by TRPC3/6/7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429036", "l": "SLC2A9 transports Fru, Glc, urate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17912", "l": "(S)-lactate <=> acetaldehyde + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69291", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate <=> sulfate + sulforaphane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5576895", "l": "SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944227", "l": "Association of procollagen type XXII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052681", "l": "alpha-bisabolene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,R)-alpha-bisabolene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38447", "l": "4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O = 4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose", "d": []}, {"i": "EC:3.2.1.187", "l": "\"(Ara-f)3-Hyp beta-L-arabinobiosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15948", "l": "aldehydo-D-glucose 6-phosphate + L-lysyl-[protein] <=> H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036430", "l": "CMP kinase activity", "d": ["Catalysis of the reaction: ATP + CMP = ADP + CDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72697", "l": "Start codon recognition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16986", "l": "3-oxoadipate + NADP(+) => H(+) + maleylacetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15426", "l": "coproporphyrinogen III + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018522", "l": "benzoyl-CoA reductase activity", "d": ["Catalysis of the reaction: 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 phosphate = 2 ATP + 2 H2O + benzoyl-CoA + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36826", "l": "1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol <=> CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43662", "l": "ADP + H(+) + methylmalonyl-CoA + phosphate => ATP + hydrogencarbonate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61750", "l": "H(+) + stevioside + UDP => rubusoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15858", "l": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+) => 17alpha-hydroxyprogesterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612445", "l": "STMN1 gene expression is stimulated by ERBB4s80 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691004", "l": "XPC binds RAD23 and CETN2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018774", "l": "RHOBTB1 binds GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73631", "l": "CTP(out) + dGTP(in) = CTP(in) + dGTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66589", "l": "a cytidine in 26S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-179417", "l": "Multiubiquitination of Nek2A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73996", "l": "geranylgeranyl diphosphate + H2O => (S)-(+)-nephthenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15222", "l": "a CDP-1,2-diacyl-sn-glycerol + H2O => a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75119", "l": "all-trans-13,14-dihydroretinal + H2O + NAD(+) = all-trans-13,14-dihydroretinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49506", "l": "phosphinomethylisomalate => phosphinomethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592387", "l": "Fibulin binds elastic fibres (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40178", "l": "O2 + octanoyl-CoA <=> (2E)-octenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41306", "l": "H2O + N-dodecanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + dodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354087", "l": "Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694427", "l": "MIA3 binds procollagen VII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52920", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509838", "l": "ITPA hydrolyses dITP to dIMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003863", "l": "3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity", "d": ["Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381798", "l": "PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754130", "l": "CDK4 inhibitors bind CDK4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044876", "l": "hercynylselenocysteine synthase", "d": ["Catalysis of the reaction: 2 L-selenocysteine + 2 hercynine + O2 = 2 H2O + 2 hercynylselenocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17248", "l": "3-hydroxyanthranilate + O2 <=> 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72663", "l": "De novo formation of eIF2:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964619", "l": "PAK1 binds ARHGEF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40988", "l": "EDTA + 2 FMNH2 + 2 O2 => ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164832", "l": "ATPase synthesizes ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50703", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27484", "l": "(S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase] <=> acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13810", "l": "aspulvinone E + 2 dimethylallyl diphosphate => aspulvinone H + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983194", "l": "Kinesin-1 is a heterotetramer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696822", "l": "AKR1B15 reduces EST17b to E1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51110", "l": "10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38377", "l": "bisanhydrobacterioruberin + 2 H2O => bacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952128", "l": "RUNX3 binds TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63038", "l": "NH4(+) + octadecanoate => H2O + octadecanamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65924", "l": "2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine = 2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428752", "l": "Dissociation of the TP:Gq complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57622", "l": "H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase] => dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852362", "l": "GTSE1 binds CDKN1A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57854", "l": "2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase => a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72627", "l": "2 H(+)(out) + Zn(2+)(in) = 2 H(+)(in) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68610", "l": "Formation of ORC(2-5) complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24953", "l": "1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O => ADP + H(+) + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685230", "l": "CHEK1 phosphorylates RAD51 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350388", "l": "ROK binds to activated RHO1:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56396", "l": "[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803892", "l": "SFN dimer binds BAX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32235", "l": "(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49737", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate => CO2 + deoxyviolacein + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8866277", "l": "AP-2 directly binds some endocytic cargo (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607753", "l": "CARD9 oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097748", "l": "3'-5' RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 5'-end."]}, {"i": "RHEA:57528", "l": "a 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O = a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687724", "l": "GSK3B binds GSKi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130151", "l": "Dimerization of DAP12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28817", "l": "4-hydroxybenzoate(out) + H(+)(in) => 4-hydroxybenzoate(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63866", "l": "(2R)-2-hydroperoxyoctadecanoate => O2 + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58443", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682983", "l": "ATM phosphorylates WHSC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956684", "l": "ITCH polyubiquitinates TP73 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433374", "l": "Processing of SCF isoform 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202721", "l": "JAM2 binds JAM3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618093", "l": "ATP hydrolysis by HSP90 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75710", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate <=> 10,11-epoxy-12-hydroxy-(14Z,17Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76015", "l": "(3R)-hydroxybutanoate trimer + H2O = (3R)-hydroxybutanoate dimer + (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74137", "l": "petunidin 3-O-beta-D-galactoside + UDP => petunidin + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796368", "l": "RIPK1 binds STUB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607740", "l": "PKC-delta phosphorylates CARD9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618834", "l": "Activated calmodulin dissociates from CaMKII-gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450088", "l": "GLUT1 tetramer binds 4xATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16625", "l": "acetyl-CoA + hydrogen sulfide = CoA + thioacetate", "d": []}, {"i": "EC:2.3.1.10", "l": "\"hydrogen-sulfide S-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25476", "l": "(2E,6E)-farnesyl diphosphate = alpha-himachalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21698", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59042", "l": "4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050183", "l": "phosphatidylcholine 12-monooxygenase activity", "d": ["Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + H+ + NADH + O2 = 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72095", "l": "(S)-carnitine(out) + Na(+)(out) = (S)-carnitine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25526", "l": "9alpha-copalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093329", "l": "EFNBs bind SDCBP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0046573", "l": "lactonohydrolase activity", "d": ["Catalysis of the hydrolysis of lactone rings (intramolecular cyclic esters) to produce a hydroxyl group and a carboxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2514790", "l": "Elastin degradation by MMP14 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139918", "l": "Phosphorylation of BIM by JNK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36979", "l": "(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14557", "l": "H2O + raucaffricine = D-glucose + vomilenine", "d": []}, {"i": "EC:3.2.1.125", "l": "\"raucaffricine beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694563", "l": "ABHD10 hydrolyses MPAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-417890", "l": "P2Y5 receptor can bind to LPA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682863", "l": "RNF168 binds DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47876", "l": "ganglioside GD1b + H2O = ganglioside GM1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54888", "l": "(1S,2S)-OPC-8 + ATP + CoA = AMP + diphosphate + OPC8-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32102", "l": "S-adenosyl-L-methionine + TRIBOA beta-D-glucoside <=> DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55976", "l": "glutathione + thiosulfate = H(+) + S-sulfanylglutathione + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048257", "l": "3'-flap endonuclease activity", "d": ["Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53670", "l": "(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69736", "l": "phenylsuccinate + succinyl-CoA => 2-phenylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36402", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) <=> H(+) + NADPH + zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67675", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27844", "l": "2'-aminobiphenyl-2,3-diol + NADP(+) => 9H-carbazole + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55759", "l": "2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 <=> a 2-hydroxyornithine lipid + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43594", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral => all-trans-zeaxanthin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32619", "l": "L-threo-7,8-dihydrobiopterin + NADP(+) = H(+) + NADPH + sepiapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13180", "l": "6-phospho-5-dehydro-2-deoxy-D-gluconate <=> 3-oxopropanoate + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68954", "l": "Mcm2-7 is phosphorylated by DDK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62405", "l": "(R)-2-hydroxyhexadecanoate + O2 => CO2 + H2O + pentadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9604308", "l": "NICD4 traffics to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093342", "l": "SDC2 multimerises (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69949", "l": "3-dehydro-6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77081", "l": "Formation of the CE:GMP intermediate complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72042", "l": "nicotinate(in) + orotate(out) <=> nicotinate(out) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73081", "l": "S-adenosyl-L-homocysteine + scutellarein 7-methyl ether => S-adenosyl-L-methionine + scutellarein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686410", "l": "BLM mediates dissolution of double Holliday junction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354066", "l": "Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.101", "l": "\"L-proline amide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36260", "l": "a 1-(1-hydroxyalkyl)-sn-glycerol => an aldehyde + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139920", "l": "Translocation of tBID to mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103091", "l": "2-(7'-methylthio)heptylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxo-9-methylthiononanoate + acetyl-CoA + H2O <=> H+ + 2-(7'-methylthio)heptylmalate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63886", "l": "H2O + L-dopa => H2O2 + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018808", "l": "trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity", "d": ["Catalysis of the reaction: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate + H2O = pyruvate + 1-hydroxy-2-naphthaldehyde."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046570", "l": "methylthioribulose 1-phosphate dehydratase activity", "d": ["Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61403", "l": "ATP + N(6)-(D-ribulosyl)-L-lysine <=> ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59366", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+) => 1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963864", "l": "CUBN dissociates from 25(OH)D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28627", "l": "O2 + reduced [NADPH--hemoprotein reductase] + solavetivol = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66512", "l": "1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428917", "l": "G13 activation by TP receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210923", "l": "cya and lef bind to pagA(197-794):ANTXR1 oligomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41673", "l": "1-O-hexadecyl-sn-glycerol + ATP => 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170149", "l": "Translocation of active Cdc25C to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19529", "l": "isovitexin + UDP-alpha-D-glucose = H(+) + isovitexin 2''-O-beta-D-glucoside + UDP", "d": []}, {"i": "EC:2.4.1.106", "l": "\"isovitexin beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43475", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34732", "l": "15-methylhexadecasphing-4-enine + a fatty acyl-CoA => CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11798", "l": "3-dehydroecdysone + H2O2 => ecdysone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3785684", "l": "Fibronectin degradation by CTSG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34857", "l": "N-(cyanomethyl)glycine + NH4(+) => 2 H2O + iminodiacetonitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43233", "l": "H2O + isatin => H(+) + isatinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013159", "l": "CDC42 GEFs activate CDC42 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9635452", "l": "Pks5 transforms LFCA adenylate ester to mycocerosyl (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52670", "l": "[amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54449", "l": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O => a tRNA + an N-acyl-L-amino acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.35", "l": "\"pyridoxal kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700120", "l": "PTN and MDK bind to PTPRZ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21402", "l": "CO2 + NADPH + succinyl-CoA => 2-oxoglutarate + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26163", "l": "(S)-2,3-epoxysqualene <=> thalianol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42952", "l": "cytidine(49) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15253", "l": "cis-aconitate + H(+) = CO2 + itaconate", "d": []}, {"i": "EC:4.1.1.6", "l": "\"cis-aconitate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2530429", "l": "Formation of soluble VTN:C5b-C9  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62573", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine => glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5336182", "l": "GPR37 binds prosaptide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65339", "l": "chrodrimanin T + H(+) + NADPH + O2 <=> chrodrimanin A + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23593", "l": "glycerol + NADP(+) => D-glyceraldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24057", "l": "a myo-inositol phosphate + H2O => myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73521", "l": "dUTP(in) + UTP(out) => dUTP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036204", "l": "abieta-7,13-dien-18-ol hydroxylase activity", "d": ["Catalysis of the reaction: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18-al + NADP+ + 2 H2O. This is a two step reaction. The first step is: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18,18-diol + + NADP+ + H2O. The second step is a spontaneous reaction: abieta-7,13-dien-18,18-diol = abieta-7,13-dien-18-al + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35826", "l": "5,6,7,8-tetrahydromethanopterin + NAD(+) <=> 7,8-dihydromethanopterin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018563", "l": "2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxyethylbenzene + O2 = H+ + 2-hydroxy-6-oxoocta-2,4-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112727", "l": "Serine phosphorylation of STATs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.29", "l": "\"N-acylhexosamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30582", "l": "H2O + O-phospho-L-threonine <=> L-threonine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004334", "l": "fumarylacetoacetase activity", "d": ["Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685318", "l": "BCDX2 complex formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60270", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.12", "l": "\"Met-Xaa dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54350", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0008900", "l": "P-type potassium:proton transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72856", "l": "ADP(out) + dADP(in) => ADP(in) + dADP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26252", "l": "H(+) + levopimaradienol + NADPH + O2 <=> 2 H2O + levopimaradienal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374663", "l": "DCC interaction with Ezrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24442", "l": "ADP + H(+) + 2 phosphate(in) => ATP + H2O + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181156", "l": "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22136", "l": "7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 = chlorophyllide b + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210912", "l": "Furin cleaves ANTXR2-bound pagA to yield pagA(197-794) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24310", "l": "7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381461", "l": "Plasmin proteolyzes IGF:IGFBP-3:ALS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042768", "l": "ecdysteroid 2-hydroxylase activity", "d": ["Catalysis of the hydroxylation of an ecdysteroid at carbon position 2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004309", "l": "exopolyphosphatase activity", "d": ["Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71011", "l": "L-isoleucine(in) + L-phenylalanine(out) = L-isoleucine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9620103", "l": "ALDH2 transforms GTN to NO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65187", "l": "2-oxoglutarate + O2 + preaustinoid A1 <=> berkeleyone B + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985343", "l": "RUNX2 binds SOX9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168136", "l": "Activated JNKs phosphorylate c-JUN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41993", "l": "17beta-hydroxy-5alpha-androstan-3-one + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31312", "l": "(2R)-3-phosphoglycerate + ADP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75703", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate = 14,15-epoxy-12-hydroxy-(10E)-eicosenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13836", "l": "L-arginine + pyruvate <=> 5-guanidino-2-oxopentanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58726", "l": "H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine => adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852200", "l": "Inactivation of LCK by PTPN22 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667914", "l": "ALK binds ligand midkine (MDK) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20347", "l": "[thioredoxin]-disulfide + H(+) + NADPH => [thioredoxin]-dithiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64397", "l": "glycyl-sarcosine(out) + H(+)(out) => glycyl-sarcosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9724685", "l": "IgE binds omalizumab (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47504", "l": "chenodeoxycholate + NADP(+) = 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14994", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH => a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448958", "l": "Nuclear translocation of p38 MAPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417127", "l": "Elongation and translocation of the extended telomeric chromosome end (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654603", "l": "Activated FGFR2 binds FRS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20157", "l": "a polyvinyl alcohol + 2n Fe(III)-[cytochrome c] = an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+)", "d": []}, {"i": "EC:1.1.2.6", "l": "\"polyvinyl alcohol dehydrogenase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624800", "l": "CDK1 phosphorylates LBR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211356", "l": "Anthrax lef cleaves target cell MAP2K2 (MEK2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031217", "l": "glucan 1,4-beta-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans, to remove successive glucose units."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214405", "l": "Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.3", "l": "\"cystinyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180599", "l": "The Vpu:CD4:beta-TrCP complex recruits SKP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549129", "l": "OCT1 transports organic cations into hepatic cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851933", "l": "MET phosphorylates GAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102933", "l": "GDP-4-dehydro-6-deoxy-D-mannose-4-aminotransferase activity", "d": ["Catalysis of the reaction: GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate = GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37573", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.88", "l": "\"tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18271", "l": "ethyl 3-oxohexanoate + H(+) + NADPH => ethyl (S)-3-hydroxyhexanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41119", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31721", "l": "11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693536", "l": "ATM phosphorylates MDC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21125", "l": "cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110307", "l": "REV1 binds AP-dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68302", "l": "CoA + O-tetradecanoyl-L-seryl-[protein] => L-seryl-[protein] + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61087", "l": "(2S)-naringenin + 2-oxoglutarate + O2 <=> (2R,3R)-dihydrokaempferol + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43925", "l": "NAD(+) + pregnenolone => H(+) + NADH + pregn-5-ene-3,20-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40595", "l": "dodecanedioyl-CoA + H2O = CoA + dodecanedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204873", "l": "Interaction of Tie2 and Shp2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42332", "l": "ATP + L-glutamate + oxidized coenzyme F420-2 = ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate", "d": []}, {"i": "EC:6.3.2.32", "l": "\"coenzyme gamma-F420-2:alpha-L-glutamate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032500", "l": "muramyl dipeptide binding", "d": ["Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60046", "l": "alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP => beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69488", "l": "O2 + tetradecan-1-ol = H2O2 + tetradecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31815", "l": "(2E,6E)-farnesyl diphosphate = (+)-(E)-beta-caryophyllene + diphosphate", "d": []}, {"i": "EC:4.2.3.89", "l": "\"(+)-beta-caryophyllene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799332", "l": "ATR phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31659", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61091", "l": "(S)-eriodictyol + 2-oxoglutarate + O2 <=> (2R,3R)-dihydroquercetin + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64515", "l": "(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine <=> 6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24092", "l": "2 H(+) + O2 + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H2O", "d": []}, {"i": "EC:1.21.3.4", "l": "\"sulochrin oxidase [(+)-bisdechlorogeodin-forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0004576", "l": "oligosaccharyl transferase activity", "d": ["Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656248", "l": "Defective SLC4A1 does not exchange Cl- for HCO3- (in erythrocytes) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52998", "l": "[eIF5A protein]-deoxyhypusine + NAD(+) => [eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69689", "l": "beta-D-glucose + genistein => genistein 7-O-beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140944", "l": "histone H4K20 monomethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl20-[histone H4] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl20-[histone H4] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 20 of histone H4, producing histone H4K20me."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417927", "l": "P2Y2 receptor binds ATP and UTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050232", "l": "putrescine oxidase activity", "d": ["Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20017", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 = 5,10-methylenetetrahydromethanopterin + H(+)", "d": []}, {"i": "EC:1.12.98.2", "l": "\"5,10-methenyltetrahydromethanopterin hydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018669", "l": "3-hydroxybenzoate 6-monooxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxybenzoate + H+ + NADH + O2 = 2,5-dihydroxybenzoate + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961840", "l": "E2F1 binds the CCNE1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59304", "l": "3'-phosphoadenylyl sulfate + firefly L-luciferin = adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36823", "l": "1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol = CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate", "d": []}, {"i": "EC:2.7.8.39", "l": "\"archaetidylinositol phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63775", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14761", "l": "H(+) + hexadecanoyl-CoA + L-serine = 3-oxosphinganine + CO2 + CoA", "d": []}, {"i": "EC:2.3.1.50", "l": "\"serine C-palmitoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388814", "l": "Grb2 binds CD28 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70168", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10055", "l": "(R)-2-hydroxy-4-methylpentanoate + NAD(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0009389", "l": "dimethyl sulfoxide reductase activity", "d": ["Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018595", "l": "alpha-pinene monooxygenase activity", "d": ["Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + pinocarveol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.2.7", "l": "\"methanol dehydrogenase (cytochrome c)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32119", "l": "GDP-valienol + validamine 7-phosphate = GDP + H(+) + validoxylamine A 7'-phosphate", "d": []}, {"i": "EC:2.5.1.135", "l": "\"validamine 7-phosphate valienyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709601", "l": "Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72157", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out) => 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30261", "l": "2 a menaquinone + 2 H2O => 2 a menaquinol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36553", "l": "3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+) => 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000074", "l": "TCN2 binds RCbl in the circulation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72402", "l": "2-oxoglutarate(out) + estrone 3-sulfate(in) <=> 2-oxoglutarate(in) + estrone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33987", "l": "(+)-copalyl diphosphate = diphosphate + neoabietadiene", "d": []}, {"i": "EC:4.2.3.132", "l": "\"neoabietadiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58154", "l": "2 H(+) + NADH + phosphonoacetate => H2O + NAD(+) + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27849", "l": "(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012689", "l": "IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31053", "l": "4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+) => (3R)-beta-leucine + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72852", "l": "ADP(out) + AMP(in) => ADP(in) + AMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59654", "l": "D-xylotetraonate + H(+) => D-xylotetraono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785213", "l": "LIPC dimer binds heparin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58038", "l": "8-epi-inunolide + H2O => 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.76", "l": "\"deoxyadenosine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626228", "l": "The distal appendage proteins recruit TTBK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691621", "l": "C5 binds C5 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72672", "l": "6-hydroxyphenazine-1-carboxylate + 2 H(+) + NADH + O2 => 1,6-dihydroxyphenazine + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638845", "l": "CERK phosphorylates CERA to form C1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209891", "l": "Dopamine is oxidised to noradrenaline (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65427", "l": "AMP(in) + NAD(+)(out) <=> AMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213208", "l": "Type X collagen associates with collagen type II fibrils (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38378", "l": "bacterioruberin <=> bisanhydrobacterioruberin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690023", "l": "NUBPL binds 4Fe-4S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186786", "l": "Autophosphorylation of PDGF beta receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354060", "l": "Translocation of RIAM to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68549", "l": "O2 + psoralen + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + xanthotoxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36300", "l": "(E)-caffeate + ATP + CoA => (E)-caffeoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050348", "l": "trehalose O-mycolyltransferase activity", "d": ["Catalysis of the reaction: 2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19281", "l": "(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] = acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen", "d": []}, {"i": "EC:1.14.14.141", "l": "\"psoralen synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805205", "l": "GPR35 binds kynurenic acid (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839102", "l": "BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5669240", "l": "FLNA binds PAK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20506", "l": "an alpha-(gamma-L-glutamyl)-L-amino acid => 5-oxo-L-proline + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009014", "l": "succinyl-diaminopimelate desuccinylase activity", "d": ["Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H2O = LL-2,6-diaminopimelate + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16207", "l": "N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate => H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70198", "l": "ATP + deamido-NAD(+) <=> ADP + H(+) + nicotinate-adenine dinucleotide 3'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947531", "l": "Molybdenum ion transfer onto molybdopterin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3601585", "l": "PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047827", "l": "D-lysopine dehydrogenase activity", "d": ["Catalysis of the reaction: D-lysopine + H2O + NADP+ = L-lysine + H+ + NADPH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047197", "l": "triglyceride-sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: a 3-beta-hydroxysterol + triacylglycerol = a 3-beta-hydroxysterol ester + 1,2-diacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10495", "l": "H2O + phosphocholine <=> choline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809010", "l": "COPI vesicle uncoating (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50939", "l": "(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate <=> acetoacetyl-CoA + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13120", "l": "O-acetyl-L-serine + pyrazole <=> 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48618", "l": "glycine + leukotriene E4 => H2O + leukotriene D4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21635", "l": "2 catechol + O2 <=> 2 1,2-benzoquinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70572", "l": "D-glucose(out) + Na(+)(out) => D-glucose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848250", "l": "ACBD6 binds LCFA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426158", "l": "SREBP1A,1C binds the GPAM promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42574", "l": "2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2 => 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41804", "l": "3-oxobutanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxybutanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3159259", "l": "MMAA:MUT binds AdoCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29865", "l": "ADP + GDP => AMP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57552", "l": "[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694421", "l": "PP6 dephosphorylates SEC24 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141439", "l": "Release of activated MAD2 from kinetochores (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201457", "l": "BMP2 binds to the receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9621179", "l": "Cinaciguat binds sGC:NO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51241", "l": "(9Z,12Z)-octadecadienoate + O2 => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.182", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31200", "l": "(3S)-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10024", "l": "L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388830", "l": "PI3K binds ICOS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22655", "l": "2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O <=> 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33568", "l": "A + ethanol => acetaldehyde + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20957", "l": "2-phenylacetate + ATP + CoA => AMP + diphosphate + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734687", "l": "ORC6 is phosphorylated on T195 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45057", "l": "deoxynogalonate + O2 => H(+) + H2O + nogalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043856", "l": "anti-sigma factor antagonist activity", "d": ["The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709273", "l": "BRCA2 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804425", "l": "TP53 binds POU4F2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31514", "l": "chenodeoxycholoyl-CoA + H2O <=> chenodeoxycholate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12580", "l": "H2O + NAD(+) + tauropine = H(+) + NADH + pyruvate + taurine", "d": []}, {"i": "EC:1.5.1.23", "l": "\"tauropine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70237", "l": "an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22543", "l": "5'-dehydroadenosine + H2O + O2 <=> 9-riburonosyladenine + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42358", "l": "3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA => (9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16265", "l": "O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate = 5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.96", "l": "\"5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56696", "l": "D-ribulose 5-phosphate + L-tryptophan = (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": []}, {"i": "EC:4.1.99.25", "l": "\"L-tryptophan isonitrile synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617179", "l": "PRKACA phosphorylates TNNI3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868608", "l": "Trehalose-6-phosphate is hydrolyzed to trehalose (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.741834732726957", "identifiers": [{"i": "GO:0004518", "l": "nuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33842", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) <=> 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624158", "l": "Substrate:LAMP2a:HSP90 polymerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250217", "l": "ARL2:GTP binds ARL2BP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30867", "l": "H2O + indole-3-acetaldehyde + NAD(+) = (indol-3-yl)acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49757", "l": "H(+) + O2 + protoviolaceinate => CO2 + H2O + proviolacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28518", "l": "D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate", "d": []}, {"i": "EC:3.1.3.82", "l": "\"D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68741", "l": "7-oxocholesterol + H(+) + NADPH => 7alpha-hydroxycholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3790137", "l": "Stimulation of IL8 transcription in senescent cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25365", "l": "H(+) + momilactone A + NADH => 3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004038", "l": "allantoinase activity", "d": ["Catalysis of the reaction: allantoin + H2O = allantoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662620", "l": "MT3 binds cadmium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114552", "l": "Thrombin-activated PARs activate G12/13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10542", "l": "6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde => 7,8-dihydroneopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683663", "l": "N-glycan trimming of Spike (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603419", "l": "Activated NTRK3 binds SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14614", "l": "ATP + H2O + taurine(out) => ADP + H(+) + phosphate + taurine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140758", "l": "metal-dependent deNEDDylase activity", "d": ["An metal-dependent isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102362", "l": "esculetin 3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: esculetin + UDP-alpha-D-glucose <=> 3-O-beta-D-glucosyl-esculetin + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29999", "l": "ATP + H2O + spermidine(out) = ADP + H(+) + phosphate + spermidine(in)", "d": []}, {"i": "EC:7.6.2.11", "l": "\"ABC-type polyamine transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395784", "l": "Nascent CMs transform into mature CMs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.60", "l": "\"protein geranylgeranyltransferase type II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33964", "l": "ATP + isopentenyl phosphate => ADP + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21324", "l": "2 H(+) + reduced [rubredoxin] + superoxide = H2O2 + oxidized [rubredoxin]", "d": []}, {"i": "EC:1.15.1.2", "l": "\"superoxide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.4", "l": "\"fatty-acid peroxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43565", "l": "4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine => [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857686", "l": "FITM1, FITM2 bind TAGs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32152", "l": "9alpha-copalyl diphosphate => (12E)-9alpha-labda-8(17),12,14-triene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28894", "l": "H(+)(in) + putrescine(in) <=> H(+)(out) + putrescine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10381", "l": "diphosphate + orotidine 5'-phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172678", "l": "PHF8 demethylates histone H4K20me1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961952", "l": "CDT1 gene expression is stimulated by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25591", "l": "D-threo-isocitrate + NADP(+) <=> (S)-oxalosuccinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015648", "l": "lipid-linked peptidoglycan transporter activity", "d": ["Enables the directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36745", "l": "CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine => heptadecasphing-4-enine + tetracosenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74098", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + an L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56994", "l": "(+)-costunolide + H2O => 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63968", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) = atromentin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662621", "l": "MT1M binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390929", "l": "HTR1 and 5A receptors can bind serotonin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418904", "l": "A1 and A3 receptors bind adenosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19788", "l": "2-oxoglutarate + dihydroclavaminate + O2 <=> clavaminate + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17329", "l": "(1R,2S,4R)-borneol + NAD(+) = (1R,4R)-camphor + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.198", "l": "\"(+)-borneol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030740", "l": "inositol 3-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-3-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212356", "l": "Formation of CSL-NICD coactivator complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60818", "l": "CO2 + gibberellin A14 + H(+) + succinate => 2-oxoglutarate + gibberellin A14 aldehyde + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.57", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68524", "l": "(2Z,6Z)-farnesyl diphosphate = beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31910", "l": "(S)-norcoclaurine + S-adenosyl-L-methionine <=> (S)-coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73520", "l": "dUTP(out) + UTP(in) => dUTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938815", "l": "RNF152 polyubiquitinates RRAGA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65640", "l": "(4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850997", "l": "TRIM27 binds PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.54", "l": "\"ketosteroid monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30599", "l": "15-cis-phytoene + 3 A = 3 AH2 + all-trans-neurosporene", "d": []}, {"i": "EC:1.3.99.28", "l": "\"phytoene desaturase (neurosporene-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25452", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + germacrene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57219", "l": "dGTP + glyoxal <=> N(2)-(1-hydroxy-2-oxoethyl)-dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167427", "l": "Opioid dissociates from MOR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17537", "l": "(R)-carnitinamide + H2O = (R)-carnitine + NH4(+)", "d": []}, {"i": "EC:3.5.1.73", "l": "\"carnitinamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42085", "l": "9-cis-retinal + H2O + NAD(+) => 9-cis-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.19", "l": "\"C-19 steroid 1alpha-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749253", "l": "Formation of MCM2-7 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66101", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine => H2O + kynurenate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605595", "l": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70136", "l": "6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448629", "l": "IL33 binds IL1RL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33717", "l": "2-hydroxyoctadecanal + phosphoethanolamine => 4-hydroxyeicosasphinganine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40999", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140869", "l": "miRNA inhibitor activity via base-pairing", "d": ["Stops, prevents or reduces the activity of miRNA-mediated gene silencing activity by base-pairing with a target miRNA. An example of this activity is mediated by long non-coding RNAs (lncRNAs)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59978", "l": "CO2 + toluene => 2-phenylacetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55298", "l": "13-cis-retinyl hexadecanoate + CoA => 13-cis-retinol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804099", "l": "HMGB1 binds LTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50447", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 <=> prostaglandin G3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41320", "l": "1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033550", "l": "MAP kinase tyrosine phosphatase activity", "d": ["Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48463", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> 2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012835", "l": "GDIs block activation of RHOA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193665", "l": "MYD88 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62509", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70334", "l": "3-hydroxyphenylacetyl-CoA + H2O <=> 3-hydroxyphenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53483", "l": "3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH <=> 5alpha-androstane-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31856", "l": "(S)-2,3-epoxysqualene => achilleol B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001968", "l": "fibronectin binding", "d": ["Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58651", "l": "rifamycin SV hemiaminal <=> H(+) + rifamycin SV ortho-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050143", "l": "nocardicin-A epimerase activity", "d": ["Catalysis of the reaction: isonocardicin A = nocardicin A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706312", "l": "Active FLT3 binds to LCK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855047", "l": "Hydrolysis of internal thioester in C4b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73340", "l": "ATP + beta-alanine + H(+) => beta-alanyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655844", "l": "Expression of Squalene Monooxygenase (SQLE) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23684", "l": "(S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380782", "l": "STAT binds to the active receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70624", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46333", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63922", "l": "CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine => octadecanoyl-CoA + sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60650", "l": "an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine => an N-(acyl)-sphingosylphosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36934", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047051", "l": "D-lactate dehydrogenase (cytochrome c-553) activity", "d": ["Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c553] = 2 [Fe(II)cytochrome c553] + 2 H+ + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36902", "l": "guanosine(37) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56644", "l": "a uridine in mRNA = a pseudouridine in mRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139893", "l": "Granzyme-B activates BID by cleavage (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14621", "l": "(S)-2,3-epoxysqualene = lanosterol", "d": []}, {"i": "EC:5.4.99.7", "l": "\"lanosterol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30884", "l": "D-glucurono-3,6-lactone + 2 H2O + NAD(+) => D-glucarate + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22399", "l": "1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 <=> glycolaldehyde + guaiacol + H2O + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985799", "l": "SLIT1 binds ROBO1,(ROBO2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57092", "l": "AH2 + S-(methylsulfanyl)glutathione = A + glutathione + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61354", "l": "ADP + H(+) + phosphate + riboflavin(out) => ATP + H2O + riboflavin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53141", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166220", "l": "FA anion diffuses laterally to UCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399939", "l": "Autophosphorylation of PAK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0016671", "l": "oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide."]}, {"i": "EC:1.8.4.-", "l": "\"With a disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38686", "l": "ATP + H2O + sphing-4-enine(in) <=> ADP + H(+) + phosphate + sphing-4-enine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49606", "l": "2-glutathionyl-2-methylbut-3-enal + H(+) + NADH => 2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40783", "l": "docosanoyl-CoA + H2O = CoA + docosanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733973", "l": "Bile salts bind FABP6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57381", "l": "(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74851", "l": "acetaldehyde + dopamine = (R)-salsolinol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451942", "l": "Within the IL-2R complex JAK3 phosphorylates JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53613", "l": "CTP + D-ribulose 5-phosphate + H(+) => CDP-D-ribulose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55496", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41443", "l": "(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 <=> (1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49911", "l": "(R)-carnitine(out) + O-acetyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-acetyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43611", "l": "agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O <=> 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30725", "l": "AH2 + 2 ATP + H2O + hydroxylamine => A + 2 ADP + H(+) + NH4(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102029", "l": "D-lactate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: (R)-lactate + an ubiquinone = pyruvate + an ubiquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54605", "l": "2-oxoglutarate + decanoyl-CoA + O2 => 2-hydroxydecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30936", "l": "H2O + nicotinate beta-D-ribonucleotide => beta-D-ribosylnicotinate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357472", "l": "PAK1-3 autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73779", "l": "dimethylallyl diphosphate + preechinulin = diphosphate + tardioxopiperazine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59409", "l": "H2O + N-acetyl-L-aspartate => acetate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429497", "l": "SLP-76 stimulates PLC gamma 2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939852", "l": "RUNX2 and SP7 bind the UCMA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202960", "l": "Caspase mediated cleavage of C-IAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29057", "l": "a ubiquinol + 2 H(+)(out) => a ubiquinone + 2 H(+)(in) + H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59279", "l": "L-glutamine <=> D-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24997", "l": "N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46628", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH = androst-5-en-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24106", "l": "7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine => 7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726621", "l": "PGR binds PGR antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13181", "l": "ATP + H2O + nitrate(out) = ADP + H(+) + nitrate(in) + phosphate", "d": []}, {"i": "EC:7.3.2.4", "l": "\"ABC-type nitrate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043917", "l": "ribose 1,5-bisphosphate isomerase activity", "d": ["Catalysis of the reaction: D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63391", "l": "2 A + Fe(II)-heme o + H2O <=> 2 AH2 + Fe(II)-heme a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51530", "l": "CO2 + guaiacol => H(+) + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046577", "l": "long-chain-alcohol oxidase activity", "d": ["Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9761344", "l": "USP18 binds IKBKG within IKK complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396347", "l": "NOTCH1 Coactivator Complex binds HES1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102404", "l": "linalyl 6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity", "d": ["Catalysis of the reaction: linalyl 6-O-alpha-L-arabinopyranosyl- beta-D-glucopyranoside + H2O <=> vicianose + linalool."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647994", "l": "RAS proteins are depalmitoylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10424", "l": "H2O + N-benzoylglycine = benzoate + glycine", "d": []}, {"i": "EC:3.5.1.32", "l": "\"hippurate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647977", "l": "ICMT methylates S-Farn RAS proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34078", "l": "an acyl phosphate + sn-glycerol 3-phosphate <=> a 1-acyl-sn-glycero-3-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53463", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5631885", "l": "PRDX1 overoxidizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2471842", "l": "Collagen type XXV ectomain shedding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938773", "l": "RNF144A polyubiquitinates PRKDC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444047", "l": "Receptor FFAR3 binds carboxylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58650", "l": "H(+) + rifamycin SV ortho-naphthoquinone carboxamide => rifamycin SV hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103111", "l": "D-glucosamine PTS permease activity", "d": ["Catalysis of the reaction: a [PTS enzyme I]-Npi-phospho-L-histidine + D-glucosamine <=> D-glucosamine 6-phosphate + a [PTS enzyme I]-L-histidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.44", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69426", "l": "acetone + formyl-CoA => 2-hydroxyisobutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9681294", "l": "IL6R binds IL6R inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.151", "l": "\"xyloglucan-specific endo-beta-1,4-glucanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67166", "l": "6'-bromomelleolide F + FAD + 2 H2O => bromide + FADH2 + melleolide F + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509831", "l": "ITPA hydrolyses XTP to XMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74522", "l": "1-(3-O-sulfo-beta-D-galactosyl)-ceramide + H2O <=> beta-D-Gal-(1<->1')-Cer + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3245898", "l": "TCN1 binds correnoids in the circulation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71550", "l": "5-phosphomethyl-dUMP in DNA + glycine <=> 5-N(alpha)-glycyl-dTMP in DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730856", "l": "Autophosphorylation of PAK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56341", "l": "ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682598", "l": "ATM phosphorylates HERC2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62910", "l": "H(+) + S-adenosyl-L-homocysteine + toralactone => nor-toralactone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42312", "l": "H(+) + NADP(+) + 2 reduced [adrenodoxin] = NADPH + 2 oxidized [adrenodoxin]", "d": []}, {"i": "EC:1.18.1.6", "l": "\"adrenodoxin-NADP(+) reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624112", "l": "CEBPA binds CDK4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65705", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-3,6-dideoxy-alpha-D-mannose => alpha-D-Tyv-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59203", "l": "ATP + docosanoate + H(+) <=> diphosphate + docosanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050816", "l": "phosphothreonine residue binding", "d": ["Binding to a phosphorylated threonine residue within a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349404", "l": "CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28373", "l": "oxaloacetate + phosphate <=> hydrogencarbonate + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615501", "l": "MIR132 gene expression is stimulated by p-S133-CREB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11083", "l": "dTMP + H2O <=> phosphate + thymidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874080", "l": "SRC phosphorylates PTK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080048", "l": "GDP-D-glucose phosphorylase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-glucose + phosphate = alpha-D-glucose-1-phosphate + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2545203", "l": "Deacetylation of cleaved cohesin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65310", "l": "a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP] => an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29172", "l": "a ubiquinol + 2 O2 => a ubiquinone + 2 H(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6813749", "l": "ALDH1A1 oxidises GA to DGA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-398040", "l": "Gbeta:gamma activation of PLC beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43541", "l": "ATP + L-seryl-[isocitrate dehydrogenase] => ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800794", "l": "PIDD1 associates with CRADD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391934", "l": "DP2 receptor can bind PGD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55738", "l": "[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP => alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186780", "l": "PI3-kinase binds to the active receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936979", "l": "RUNX1 and GATA1 bind the promoter of the THBS1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871226", "l": "RET binds GFRA1,GFRA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11808", "l": "bergaptol + S-adenosyl-L-methionine = bergapten + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66333", "l": "L-aspartate(out) => L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.9", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004757", "l": "sepiapterin reductase activity", "d": ["Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68382", "l": "2-oxosuccinamate + L-serine => 3-hydroxypyruvate + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62773", "l": "N-acetyl-D-phenylalanine => N-acetyl-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52937", "l": "3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O => (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0004046", "l": "aminoacylase activity", "d": ["Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800490", "l": "ATM phosphorylates PIDD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37879", "l": "methyl aklanonate = aklaviketone", "d": []}, {"i": "EC:5.5.1.23", "l": "\"aklanonic acid methyl ester cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429992", "l": "PARN deadenylates mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44211", "l": "12-methyltridecanoate + ATP + CoA <=> 12-methyltridecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39692", "l": "(2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH => (11Z)-octadecenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205289", "l": "Autophosphorylation of KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42048", "l": "3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193668", "l": "p75NTR and RHOA-GDI interact (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63699", "l": "SN-38 + UDP-alpha-D-glucuronate <=> H(+) + SN-38 O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10636", "l": "D-mannonate + NADP(+) = D-mannuronate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114683", "l": "Phosphorylation of Platelet Sec-1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.125", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.-", "l": "\"Other lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388468", "l": "AVP(20-28) binds AVPR1A,B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42311", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17620", "l": "leukotriene C4 <=> glutathione + leukotriene A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39094", "l": "(2E)-decenedioyl-CoA + H2O <=> (3S)-hydroxydecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57623", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68059", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O <=> a 3'-end 3'-phospho-ribonucleotide-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2512800", "l": "SCARB1:ligand is endocytosed (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67885", "l": "3'-phosphoadenylyl sulfate + dopamine => adenosine 3',5'-bisphosphate + dopamine 4-O-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73376", "l": "biotin(out) + 2 Na(+)(out) => biotin(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033820", "l": "DNA alpha-glucosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664271", "l": "Release of PLCG from FCGR3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72227", "l": "chloride(out) + 2 Na(+)(out) + sarcosine(out) = chloride(in) + 2 Na(+)(in) + sarcosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47564", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GA2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66230", "l": "asc-DeltaC13-CoA + H2O2 => asc-C13-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362417", "l": "Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928617", "l": "EPHB2 binds KALRN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26183", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O <=> 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36634", "l": "D-ribulose 1,5-bisphosphate + O2 <=> (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10095", "l": "a 2'-deoxyribonucleoside 3'-phosphate + H2O <=> a 2'-deoxyribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031704", "l": "apelin receptor binding", "d": ["Binding to an apelin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093329", "l": "EFNBs bind SDCBP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54963", "l": "ATP + CoA + dinor-OPDA <=> AMP + dinor-OPDA-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161282", "l": "Elastic fibres bind associated proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797554", "l": "ABP1 binds SHANK proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44412", "l": "3-demethylubiquinol-10 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166753", "l": "Conversion of C4 into C4a and C4b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5444516", "l": "Formation of MSH2:MSH6 Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10700", "l": "H2O + limonene 1,2-epoxide = limonene-1,2-diol", "d": []}, {"i": "EC:3.3.2.8", "l": "\"limonene-1,2-epoxide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22840", "l": "D-glutamine + H2O = D-glutamate + NH4(+)", "d": []}, {"i": "EC:3.5.1.35", "l": "\"D-glutaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805638", "l": "KAT6A acetylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382058", "l": "Nck binds to the active PDGF receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191830", "l": "snRNP nuclear import and release (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61543", "l": "ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-167419", "l": "The receptor:G-protein complex releases GDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69145", "l": "agmatine + H2O + O2 => 4-guanidinobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684006", "l": "KPNA2 translocates NBN to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757456", "l": "2,5-DHBA translocates from ER lumen to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37739", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799332", "l": "ATR phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71973", "l": "3-hydroxyglutarate(in) + 3 Na(+)(in) => 3-hydroxyglutarate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212642", "l": "L-Glutamine transport into neurons (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39632", "l": "(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH => (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40350", "l": "3-oxotetradecanedioyl-CoA + CoA <=> acetyl-CoA + dodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602147", "l": "Defective CYP2R1 does not 25-hydroxylate vitamin D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416358", "l": "G alpha (q) inhibits PI3K alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17680", "l": "2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O <=> 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20827", "l": "adenosine + ATP <=> ADP + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13462", "l": "3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2 => 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805640", "l": "AKT phosphorylates KAT6A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53807", "l": "allodeoxycholoyl-CoA + ursodeoxycholate <=> allodeoxycholate + ursodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38295", "l": "(R)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2", "d": []}, {"i": "EC:1.1.99.39", "l": "\"D-2-hydroxyglutarate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28223", "l": "3-dehydro-L-gulonate + ATP => 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16742", "l": "a 2-acylglycerol + an acyl-CoA => a 1,2-diacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28008", "l": "formaldehyde + H2O2 + L-tryptophan => H2O + N(alpha)-methyl-L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72222", "l": "3 hydrogencarbonate(out) + Na(+)(out) <=> 3 hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102865", "l": "delta6-acyl-lipid desaturase activity", "d": ["Catalysis of the reaction: a gamma-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ <=> a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.47", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031473", "l": "myosin III binding", "d": ["Binding to a class III myosin; myosin III is monomeric and has an N terminal kinase domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53591", "l": "NAD(+) + resolvin D2 <=> 16-oxoresolvin D2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362465", "l": "GHBP binds GHR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052629", "l": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42968", "l": "cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.206", "l": "\"tRNA (cytidine(56)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46217", "l": "H(+) + NADPH + progesterone => 3beta-hydroxypregn-4-ene-20-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004901", "l": "granulocyte macrophage colony-stimulating factor receptor activity", "d": ["Combining with granulocyte macrophage colony-stimulating factor (GM-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390663", "l": "ADRA2A,B,C bind ADR,NAd (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48512", "l": "ATP + H2O + phosphinate(out) = ADP + H(+) + phosphate + phosphinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061483", "l": "sulfinylpropanyl adenylate synthase", "d": ["Catalysis of the reaction: cysteine sulfanate + GTP + IMP = sulfinylpropanyl adenylate + GDP + 3 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31170", "l": "(3S)-hydroxytetradecanoyl-CoA + NAD(+) <=> 3-oxotetradecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32894", "l": "(1S,5S)-alpha-pinene + H(+) + NADH + O2 <=> alpha-pinene oxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62409", "l": "3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine => 1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35343", "l": "3-hydroxydocosanoyl-CoA + NADP(+) = 3-oxodocosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2731141", "l": "Syndecan-1 binds fibronectin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21611", "l": "isoliquiritigenin + S-adenosyl-L-methionine <=> 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15797", "l": "bilirubin IXalpha + NAD(+) = biliverdin IXalpha + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033458", "l": "GAC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GAC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54979", "l": "(3S)-hydroxytetradecanoyl-CoA + H2O <=> (3S)-hydroxytetradecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12259", "l": "L-arogenate + NAD(+) <=> CO2 + L-tyrosine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6813740", "l": "GDE1 hydrolyzes GroPIns (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74011", "l": "[(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + H(+) + NADPH + O2 = [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685189", "l": "SARS-CoV-1 9b binds MAVS and PCBP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65942", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+) => (R)-glycerate + GDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65229", "l": "(1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+) => H(+) + NADPH + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371467", "l": "SIRT1 deacetylates HSF1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63491", "l": "9,10-phenanthroquinone + H(+) + NADPH <=> NADP(+) + phenanthrene-9,10-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1454916", "l": "The ABCC family mediates organic anion transport (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62534", "l": "dihydrodigitoxin + 2 Fe(III)-[cytochrome c] => digitoxin + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.32", "l": "\"scytalidopepsin B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209815", "l": "Tyrosine is monoiodinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31207", "l": "FAD + H(+) + hexanoyl-CoA = (2E)-hexenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635936", "l": "ATF4 binds the CEBPB gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29978", "l": "2'-deoxycytidine(in) + H(+)(in) <=> 2'-deoxycytidine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617179", "l": "PRKACA phosphorylates TNNI3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209536", "l": "IkB is ubiquitinated and degraded (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27863", "l": "3'-GMP + H2O => guanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.282", "l": "\"phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55937", "l": "all-trans-4-hydroxyretinol + NAD(+) => all-trans-4-hydroxyretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45807", "l": "ATP + hydroxylamine + L-glutamate <=> ADP + L-glutamine hydroxamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295613", "l": "SPRY2 binds GRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707690", "l": "BACH1 binds MAFK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51385", "l": "hexadecanoyl-CoA + serotonin => CoA + H(+) + N-hexadecanoyl-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30316", "l": "1,7-dimethylxanthine + H(+) + NADH + O2 => 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018794", "l": "RHOV binds effectors at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11456", "l": "N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}, {"i": "EC:2.4.1.101", "l": "\"alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11738", "l": "6-oxocineole + H(+) + NADH => 2-exo-hydroxy-1,8-cineole + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5082356", "l": "HSF1-mediated gene expression (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66239", "l": "IC-asc-C9-CoA + O2 <=> H2O2 + IC-asc-DeltaC9-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690785", "l": "BAP1 binds Ub-HCFC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928646", "l": "EPHAs bind EFNAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.187403162058388", "identifiers": [{"i": "GO:0004842", "l": "ubiquitin-protein transferase activity", "d": ["Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21688", "l": "a polyvinyl alcohol + n O2 = an oxidized polyvinyl alcohol + n H2O2", "d": []}, {"i": "EC:1.1.3.30", "l": "\"polyvinyl-alcohol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69334", "l": "2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32675", "l": "alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose", "d": []}, {"i": "EC:3.2.1.28", "l": "\"alpha,alpha-trehalase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50319", "l": "ethyl octadecanoate + H2O <=> ethanol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1362416", "l": "Frataxin binds iron (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56485", "l": "3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] => gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170120", "l": "Translocation of Cdc25B to the cytoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23492", "l": "UDP-alpha-D-glucosamine = UDP-alpha-D-galactosamine", "d": []}, {"i": "EC:5.1.3.16", "l": "\"UDP-glucosamine 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67103", "l": "fumigatonoid B <=> fumigatonoid C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112430", "l": "Formation of P-TEFb complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669250", "l": "PAK1 phosphorylates FLNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58882", "l": "4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26055", "l": "GTP + H(+) + valienol 1-phosphate = diphosphate + GDP-valienol", "d": []}, {"i": "EC:2.7.7.91", "l": "\"valienol-1-phosphate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852019", "l": "MET bound PI3K generates PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814090", "l": "NatC acetylates ARFFRP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50067", "l": "ATP + H2O + taurochenodeoxycholate(in) <=> ADP + H(+) + phosphate + taurochenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37874", "l": "2-heptyl-4(1H)-quinolone + H(+) + NADH + O2 <=> 2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046480", "l": "galactolipid galactosyltransferase activity", "d": ["Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = alpha-D-galactosyl-beta-D-galactosyldiacylglycerol + 1,2-diacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.26", "l": "\"DNA alpha-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097365", "l": "stretch-activated, monoatomic cation-selective, calcium channel activity involved in regulation of cardiac muscle cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential in a cardiac muscle cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909732", "l": "Phosphorylation of STAT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64415", "l": "H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) <=> H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018808", "l": "RAC3 binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29056", "l": "a ubiquinone + 2 H(+)(in) + H2 => a ubiquinol + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27535", "l": "(2E,6E)-farnesyl diphosphate + H2O => (3R,6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034011", "l": "L-cysteate sulfo-lyase activity", "d": ["Catalysis of the reaction: L-cysteate + H2O = NH4 + pyruvate + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691421", "l": "BTK binds BTK inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.41", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55795", "l": "butan-2-one + H(+) + NADH + O2 <=> 1-hydroxy-2-butanone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709454", "l": "EPOR binds EPOR agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45555", "l": "H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66077", "l": "2-oxopentanoate + L-kynurenine => H2O + kynurenate + L-2-aminopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0052744", "l": "phosphatidylinositol monophosphate phosphatase activity", "d": ["Catalysis of the reaction: phosphatidyl-1D-myo-inositol monophosphate + H2O = phosphatidylinositol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164503", "l": "First strand transfer mediated by Repeated (R) sequence (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-481007", "l": "Exocytosis of platelet alpha granule contents (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66039", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48795", "l": "GDP-beta-L-fucose + Lc4Cer <=> alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247839", "l": "Retromer associates with WLS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9681616", "l": "AP2 binds chlorpromazine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75381", "l": "L-homoserine + N-hydroxyguanidine => H2O + L-canavanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46503", "l": "2-oxoglutarate + O2 + UMP <=> CO2 + phosphate + succinate + uridine-5'-aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102838", "l": "1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21654", "l": "catechol + chloride + CO2 + NAD(+) => 2-chlorobenzoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74092", "l": "ATP + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP + H(+) + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947499", "l": "Exchange of oxygen with sulfur in MoCo (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990631", "l": "ErbB-4 class receptor binding", "d": ["Binding to the protein-tyrosine kinase receptor ErbB-4/HER4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42692", "l": "[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1->4)-alpha-D-glucosyl](n+2) + phosphate", "d": []}, {"i": "EC:2.4.99.16", "l": "\"starch synthase (maltosyl-transferring)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.29", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050579", "l": "vellosimine dehydrogenase activity", "d": ["Catalysis of the reaction: 10-deoxysarpagine + NADP+ = H+ + NADPH + vellosimine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001626", "l": "nociceptin receptor activity", "d": ["Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43753", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33398", "l": "H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester <=> GMP + N(alpha)-acetyl-L-lysine methyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71226", "l": "chloride(out) + 2 Na(+)(out) + taurine(out) <=> chloride(in) + 2 Na(+)(in) + taurine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195304", "l": "Association of beta-catenin with the destruction complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800793", "l": "PIDD1 translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433456", "l": "Recruitment of STATs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042301", "l": "phosphate ion binding", "d": ["Binding to a phosphate ion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12890", "l": "L-gulonate + NAD(+) => 3-dehydro-L-gulonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31573", "l": "CO2 + H2O + NADP(+) + naphthalene-1,2-diol => 1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64568", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one = ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14414", "l": "biphenyl-2,3-diol + O2 => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005175", "l": "CD27 receptor binding", "d": ["Binding to a CD27, a receptor found on the surface of T cells and some B cells and NK cells."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047403", "l": "lacto-N-biosidase activity", "d": ["Catalysis of the reaction: H2O + beta-D-Gal-(1,3)-beta-D-GlcNAc-(1,3)-beta-D-Gal-(1,4)-D-Glc = beta-D-Gal-(1,4)-D-Glc + beta-D-Gal-(1,3)-D-GlcNAc."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981926", "l": "RAC1 and CDC42 activate PAK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0015385", "l": "sodium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17159", "l": "ADP + H(+) + N-phosphocreatine => ATP + creatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694539", "l": "nsp15 binds nsp8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15077", "l": "H(+) + N-[(R)-pantothenoyl]-L-cysteine = (R)-pantetheine + CO2", "d": []}, {"i": "EC:4.1.1.30", "l": "\"pantothenoylcysteine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0008271", "l": "secondary active sulfate transmembrane transporter activity", "d": ["Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73399", "l": "D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450474", "l": "MK2 phosphorylates BRF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22693", "l": "3-hydroxybenzoate + H(+) + NADH + O2 => 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9821368", "l": "AKAP8L binds MLL1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29895", "l": "ATP + H2O + L-glutamine(out) = ADP + H(+) + L-glutamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58488", "l": "4-(trimethylamino)butanoate + H(+) + NADH + O2 = H2O + NAD(+) + succinate semialdehyde + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35743", "l": "H(+) + NADPH + O2 + versicolorin B = 2 H2O + NADP(+) + versicolorin A", "d": []}, {"i": "EC:1.14.19.n5", "l": "\"versicolorin B desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38904", "l": "a sphingomyelin(in) + ATP + H2O => a sphingomyelin(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19053", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": []}, {"i": "EC:3.5.4.27", "l": "\"methenyltetrahydromethanopterin cyclohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54527", "l": "acetoacetate + H(+) + methylglyoxal <=> 3-hydroxyhexane-2,5-dione + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72543", "l": "2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out) = 2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41054", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351876", "l": "Caspase-mediated cleavage of occludin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62960", "l": "7-dehydrocholesterol(in) = 7-dehydrocholesterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9709098", "l": "DHFR dimer reduces FOLA to DHF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61020", "l": "acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + 5-(carboxymethyl)uridine(34) in tRNA + CoA + 2 H(+) + L-methionine", "d": []}, {"i": "EC:2.3.1.311", "l": "\"tRNA carboxymethyluridine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22132", "l": "ATP + D-maltose(out) + H2O = ADP + D-maltose(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.5.2.1", "l": "\"ABC-type maltose transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62043", "l": "H2O + N-(octanoyl)-sphing-4-enine-1-phosphate <=> N-octanoylsphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39173", "l": "(3R)-hydroxyeicosanoyl-CoA + NADP(+) => 3-oxoeicosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51917", "l": "(2S)-2-amino-3-butenoate + H2O => 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44105", "l": "decanal + H2O + NAD(+) => decanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66214", "l": "asc-omegaDeltaC5-CoA + H2O2 => asc-omegaC5-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39741", "l": "3,12-dihydroxydodecanoate + H2O + NADP(+) => 3-hydroxydodecanoate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538835", "l": "PER binds to DCO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40859", "l": "(9Z)-hexadecenoyl-CoA + FAD + H(+) = (2E,9Z)-hexadecadienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18939", "l": "a carboxylate + L-homoserine lactone => an N-acyl-L-homoserine lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74723", "l": "Endosome acidification (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23817", "l": "2-oxoglutarate + putrescine => 4-aminobutanal + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72622", "l": "2-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) <=> methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67060", "l": "asnovolin I + S-adenosyl-L-methionine = asnovolin K + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44139", "l": "dodecanoyl-CoA + hexadecan-1-ol <=> CoA + hexadecanyl dodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14767", "l": "CO2 + excited coelenteramide h monoanion + H(+) + hnu => coelenterazine h + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052871", "l": "alpha-tocopherol omega-hydroxylase activity", "d": ["Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O ."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71560", "l": "5-N(alpha)-glycyl-dTMP in DNA + A + H2O => 5-aminomethyl-dUMP in DNA + AH2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40512", "l": "(2S)-3-sulfopropanediol + NAD(+) => (2S)-3-sulfolactaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73783", "l": "dimethylallyl diphosphate + tardioxopiperazine A = diphosphate + echinulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102790", "l": "cyanidin 5,3-O-glycosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 5-O-beta-D-glucoside + UDP-alpha-D-glucose = cyanin betaine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4608855", "l": "PRICKLE1 is degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73522", "l": "dUTP(out) + UTP(in) <=> dUTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50623", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205136", "l": "GTP-bound RAC contributes to JNK activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44663", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine <=> 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944233", "l": "Association of procollagen type XIX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5159250", "l": "ATF7IP binds SETDB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483219", "l": "PC is exchanged with PI by PITPNB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53763", "l": "allocholate + deoxycholoyl-CoA <=> allocholoyl-CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222431", "l": "Peroxynitrite is reduced to nitrite by AhpC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20128", "l": "H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420233", "l": "VIP receptors bind VIP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30193", "l": "15,9'-di-cis-phytofluene + plastoquinol-9 => 15-cis-phytoene + plastoquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73368", "l": "D-xylose(out) + 2 Na(+)(out) => D-xylose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047884", "l": "FAD diphosphatase activity", "d": ["Catalysis of the reaction: FAD + H2O = AMP + FMN."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37483", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine = 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21543", "l": "N-(5-phospho-beta-D-ribosyl)anthranilate <=> 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48599", "l": "1,2-didecanoylglycerol + H2O <=> decanoate + decanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11670", "l": "[(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate => [(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602454", "l": "proMMP9 binds TIMP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0004555", "l": "alpha,alpha-trehalase activity", "d": ["Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47811", "l": "epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985343", "l": "RUNX2 binds SOX9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9006873", "l": "IL21 receptor STAT binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69368", "l": "11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+) = 17beta-hydroxyandrost-4-ene-3,11-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51629", "l": "formate + H(+) + UTP => CO2 + dUTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30048", "l": "chloroacetaldehyde + H2O + NAD(+) => chloroacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018531", "l": "(S)-6-hydroxynicotine oxidase activity", "d": ["Catalysis of the reaction: (S)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687109", "l": "8b binds MAP1LC3B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12531", "l": "N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate <=> [hyaluronan](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944215", "l": "Association of procollagen type XX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43756", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]", "d": []}, {"i": "EC:2.3.1.266", "l": "\"[ribosomal protein S18]-alanine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-141437", "l": "Formation of the MCC complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450325", "l": "c-FOS activation by phospho ERK1/2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27758", "l": "(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.27", "l": "\"glycine cleavage system\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65617", "l": "A + cholest-4-en-3-one + H2O => 25-hydroxycholest-4-en-3-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71157", "l": "(E)-caffeate + H(+) + pyruvate => (E)-caffeoylpyruvate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61349", "l": "ATP + estrone 3-sulfate(in) + H2O => ADP + estrone 3-sulfate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66194", "l": "ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate => ATP + bilirubin-bisglucuronoside(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67943", "l": "2-hydroxyoctanoate + O2 <=> 2-oxooctanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48864", "l": "2-methylpropan-1-amine + FADH2 + O2 = FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31401", "l": "all-trans-4,4'-diapo-zeta-carotene + FADH2 => all-trans-4,4'-diapophytofluene + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50624", "l": "acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O = a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9669854", "l": "KIT binds type II TKIs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080108", "l": "S-alkylthiohydroximate lyase activity", "d": ["Catalysis of the conversion of a S-alkylthiohydroximate to a thiohydroximate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871226", "l": "RET binds GFRA1,GFRA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47004", "l": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038177", "l": "death receptor agonist activity", "d": ["Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080139", "l": "borate efflux transmembrane transporter activity", "d": ["Enables the transfer of borate from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33220", "l": "ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733203", "l": "FURIN gene transcription is stimulated by SMAD2/SMAD3:SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372542", "l": "Loading of dopamine into synaptic veiscles (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48748", "l": "D-threitol + NAD(+) = D-erythrulose + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.403", "l": "\"D-threitol dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30872", "l": "2-deoxy-D-ribose + ATP => 2-deoxy-D-ribose 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42899", "l": "L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44442", "l": "a triacylglycerol + glycerol => a 1,3-diacylglycerol + a 1-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174235", "l": "Association of Emi1 with Cdc20 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39352", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA => (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17815", "l": "H(+) + keto-D-tagaturonate + NADH => D-altronate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13684", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine <=> a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13968", "l": "H2O + L,L-cystathionine <=> L-homocysteine + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35993", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49733", "l": "H(+) + O2 + violaceinate => CO2 + H2O + violacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37853", "l": "13-dihydrodaunorubicin + H2O + NADP(+) => 13-deoxydaunorubicin + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69068", "l": "AH2 + 2 N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline = A + 2 N(delta)-hydroxy-N(omega)-methyl-L-citrulline + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14053", "l": "D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate", "d": []}, {"i": "EC:2.5.1.55", "l": "\"3-deoxy-8-phosphooctulonate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021182", "l": "MECP2 mRNA binds miR-132 RISC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983427", "l": "Expression of peptide bound class I MHC on cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14195", "l": "2,3-dihydroxybenzoate + A + H2O => 3-hydroxybenzoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13562", "l": "H2O + meso-2,6-diaminoheptanedioate + NADP(+) => (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43049", "l": "keto-D-tagatose => keto-D-sorbose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419334", "l": "Melatonin receptors can bind melatonin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110322", "l": "Formation of Pol zeta complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32212", "l": "(Z)-5-oxohex-2-enedioate => (2E,4Z)-2-hydroxyhexa-2,4-dienedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65261", "l": "verruculide C epoxide => 3-hydroxypentacecilide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.175", "l": "\"(R)-3-(aryl)lactoyl-CoA dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45290", "l": "2-glyceryl-prostaglandin G2 => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68595", "l": "ORC2 binds ORC3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52118", "l": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate => 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909720", "l": "IFN alpha/beta binds to IFNAR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25765", "l": "3-carboxy-2-oxobutanoate + H(+) + NADH => (2R,3S)-3-methylmalate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49280", "l": "FADH2 + O2 + phenol = catechol + FAD + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.20", "l": "\"phenol 2-monooxygenase (FADH2)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59642", "l": "D-xylotetraono-1,5-lactone + H2O2 => D-xylotetraose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005154", "l": "epidermal growth factor receptor binding", "d": ["Binding to an epidermal growth factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25013", "l": "H(+) + N,N-dihydroxy-L-tryptophan = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46925", "l": "(R)-2-hydroxy-4-methylpentanoyl-CoA => 4-methylpent-2-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951499", "l": "Loading of antigenic peptides on to class I MHC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707505", "l": "Hemes bind to CLEC1B dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72762", "l": "anthocyanin A6 + malonyl-CoA <=> anthocyanin A8 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44953", "l": "(2E)-octenoyl-CoA + H(+) + NADPH => NADP(+) + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429767", "l": "Passive I- efflux mediated by SMCT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45879", "l": "2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2691211", "l": "NOTCH1 HD domain mutants bind DLL4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60826", "l": "2 AMP + 2 H(+) => H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940561", "l": "MMP7 cleaves OPTC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54321", "l": "a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690702", "l": "LYN phosphorylates CD22 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662466", "l": "XYLB phosphorylates D-xylulose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62101", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64845", "l": "(2E)-geraniol + benzoyl-CoA => (2E)-geranyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70446", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + O2 <=> a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75120", "l": "all-trans-13,14-dihydroretinal + H2O + NAD(+) => all-trans-13,14-dihydroretinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641134", "l": "SMURF2 binds AXIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203774", "l": "Interaction of Csk with PAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102728", "l": "campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity", "d": ["Catalysis of the reaction: (5alpha)-campestan-3-one + NADP = H+ + campest-4-en-3-one + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48922", "l": "3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0033612", "l": "receptor serine/threonine kinase binding", "d": ["Binding to a receptor that possesses protein serine/threonine kinase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33685", "l": "3-oxoeicosasphinganine + CO2 + CoA => H(+) + L-serine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18586", "l": "D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48179", "l": "decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22793", "l": "isonocardicin A => nocardicin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25579", "l": "3 O2 + protoporphyrinogen IX <=> 3 H2O2 + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638845", "l": "CERK phosphorylates CERA to form C1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110319", "l": "Elongation by POLH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33970", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O <=> 3-maleylpyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19267", "l": "3-dehydrocarnitine + H(+) + NADH => carnitine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047366", "l": "quercetin-3-sulfate 4'-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H+ + quercetin 3,4'-disulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687088", "l": "PKA phosphorylates MAPKAPK5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56076", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13826", "l": "GDP-alpha-D-rhamnose + NAD(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29121", "l": "a ubiquinone + H2O + nitrite => a ubiquinol + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693783", "l": "NAALADases hydrolyse NAAG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25606", "l": "2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O => 2-(3-methylsulfanyl)propylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5627775", "l": "Autophosphorylation of PAK1,2,3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38045", "l": "(4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622310", "l": "Activated NOD1 oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11636", "l": "NADP(+) + prostaglandin E1 = 15-oxoprostaglandin E1 + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.197", "l": "\"15-hydroxyprostaglandin dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75610", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> plasmodiophorol B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196017", "l": "Dynamin is recruited to the gap junction plaque (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60769", "l": "3 2-oxoglutarate + gibberellin A12 + 3 O2 => 3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354073", "l": "Autophosphorylation of PTK2 at Y397 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625421", "l": "The anterograde IFT train dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65415", "l": "dAMP(in) + NAD(+)(out) <=> dAMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762343", "l": "PREDL:ALB dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2314686", "l": "ASA- acetylates PTGS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5695964", "l": "ABHD14B hydrolyses PNPB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60260", "l": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.354", "l": "\"[histone H3]-lysine(4) N-trimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55349", "l": "all-trans-retinol => 9-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44547", "l": "a fatty acid(out) + ATP + H2O <=> a fatty acid(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047094", "l": "3-hydroxyphenylacetate 6-hydroxylase activity", "d": ["Catalysis of the reaction: O2 + NAD(P)H + 3-hydroxyphenylacetate = H2O + NAD(P)+ + homogentisate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112392", "l": "Resumption of elongation after recovery from pausing (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62786", "l": "bifonsecin B + 2 H2O + NADP(+) => 2 fonsecin B + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22586", "l": "Fe(2+) + protoporphyrin IX => 2 H(+) + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57304", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP = glycolate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57146", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69353", "l": "2 (E)-prop-1-en-1-SO-peroxol => H2O + thiosulfinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036190", "l": "indole-2-monooxygenase activity", "d": ["Catalysis of the reaction: indole + NAD(P)H + H+ + O2 = indolin-2-one + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61093", "l": "H2O + N(2)-acetyl-L-citrulline => acetate + L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.43", "l": "\"arogenate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39086", "l": "3-oxododecanedioyl-CoA + CoA <=> acetyl-CoA + decanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2248891", "l": "Active ARSA translocates to the lysosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189406", "l": "4 PBGs bind to form HMB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32516", "l": "(4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O => (3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70660", "l": "H(+)(in) + N,N-dimethylglycine(in) => H(+)(out) + N,N-dimethylglycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9726509", "l": "NR3C2 binds fludrocortisone (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26280", "l": "Co-precorrin-4 + S-adenosyl-L-methionine <=> Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-452097", "l": "Recruited STAT5 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66404", "l": "ATP + glutathione(in) + H2O + taurocholate(in) = ADP + glutathione(out) + H(+) + phosphate + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008828", "l": "dATP diphosphatase activity", "d": ["Catalysis of the reaction: dATP + H2O = dAMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106219", "l": "zinc ion sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of zinc."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44275", "l": "3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008754", "l": "O antigen ligase activity", "d": ["Catalysis of the reaction: Lipid A-core + colanic acid = MLPS."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61046", "l": "(-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047030", "l": "4-hydroxycyclohexanecarboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: trans-4-hydroxycyclohexanecarboxylate + NAD+ = 4-oxocyclohexanecarboxylate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43489", "l": "7(1)-hydroxychlorophyll a + NAD(+) => chlorophyll b + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61944", "l": "24-methylenecholesterol + UDP-alpha-D-glucose = 24-methylene cholesteryl beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49058", "l": "asperlicin E + H2O + NADP(+) => asperlicin C + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63988", "l": "2-thiocytidine + ATP = 2-thiocytidine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16170", "l": "ATP + L-glutamate + NH4(+) => ADP + H(+) + L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71148", "l": "3-hydroxyhispidin + O2 => 4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27945", "l": "(3R)-3-hydroxy-D-aspartate <=> NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.054311793581761", "identifiers": [{"i": "GO:0015631", "l": "tubulin binding", "d": ["Binding to monomeric or multimeric forms of tubulin, including microtubules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46073", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADH => hexadecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918225", "l": "TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11921", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin => (6R)-L-erythro-6,7-dihydrobiopterin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59444", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A = 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33039", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin = 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9661625", "l": "FVIII is secreted (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858475", "l": "TNFSF9 binds TNFRSF9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050214", "l": "progesterone monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + O2 + progesterone = A + H2O + testosterone acetate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047442", "l": "17-alpha-hydroxyprogesterone aldolase activity", "d": ["Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35614", "l": "menadiol + 2 O2 <=> 2 H(+) + menadione + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247840", "l": "WLS binds WNT ligands in the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109857", "l": "MAP2K1 binds MAPK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50693", "l": "ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate => ADP + alpha-maltose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30706", "l": "H(+) + salicylate <=> CO2 + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688459", "l": "RIPK3 binds HSP90:CDC37 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11106", "l": "H(+) + hercynine + S-adenosyl-L-homocysteine => N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655834", "l": "SREBP1A,1C,2:SCAP translocates to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44208", "l": "12-methyltridecanoate + ATP + CoA = 12-methyltridecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787820", "l": "IL34 dimer binds CSF1R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009558", "l": "IL34 dimer binds SDC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694438", "l": "GalNAc is transferred onto 3a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389352", "l": "Translocation of Vav1 to CD28 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944218", "l": "Association of procollagen type VIII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937807", "l": "SRC phosphorylates RUNX3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24171", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009309", "l": "RUNX2 binds STUB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102389", "l": "polyprenol reductase activity", "d": ["Catalysis of the reaction: NADP + a ditrans,polycis-dolichol = NADPH + H+ + a di-trans, poly-cis-polyprenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57264", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP = GDP + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030848", "l": "threo-3-hydroxyaspartate ammonia-lyase activity", "d": ["Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH4 + oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748991", "l": "XDH oxidises 6MP to 6TU (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13750", "l": "a ribonucleoside 5'-triphosphate + AMP => a ribonucleoside 5'-diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64293", "l": "3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH => (3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42870", "l": "caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine => norspermine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-532549", "l": "MPI isomerises Fru6P to Man6P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70968", "l": "3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in) => 3-sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29816", "l": "ATP + H2O + L-proline(out) => ADP + H(+) + L-proline(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61483", "l": "a sphingoid base + a very long-chain fatty acyl-CoA <=> an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120022", "l": "glucagon family peptide binding", "d": ["Binding to a member of the glucagon family peptide hormone (e.g. glucagon, glucagon-like peptides, oxyntomodulin, glicentin, ADCYAP1, GHRH, secretin, VIP, GIP)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45319", "l": "H(+) + NADPH + prostaglandin D2 <=> 11beta-prostaglandin F2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018503", "l": "ESR1:ESTG bind the EBAG9 5' region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24538", "l": "N-formyl-L-kynurenine => L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31361", "l": "ammoniodiacetate + FMN + glyoxylate + H2O => FMNH2 + nitrilotriacetate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38060", "l": "2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA => 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39177", "l": "(2E)-eicosenoyl-CoA + H2O => (3R)-hydroxyeicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54586", "l": "an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine => a guanosine in 18S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53984", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75127", "l": "neopinone = codeinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140843", "l": "RNA polymerase II C-terminal domain S7 O-GlcNAc transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine (position 7)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17658", "l": "an acyl-CoA + dihydroxyacetone phosphate => a 1-acylglycerone 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977605", "l": "Factor H displaces Bb (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72503", "l": "glutarate(in) + prostaglandin F2alpha(out) = glutarate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353154", "l": "pyruvate + CO2 + ATP => oxaloacetate + ADP + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176445", "l": "SMURF2 binds SMAD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112271", "l": "The receptor:G-protein complex dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52780", "l": "H2O + S-(hercyn-2-yl)-L-cysteine S-oxide = 2-sulfenohercynine + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050153", "l": "omega-hydroxydecanoate dehydrogenase activity", "d": ["Catalysis of the reaction: 10-hydroxydecanoate + NAD+ = 10-oxodecanoate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610867", "l": "HCMV Binds Host Cell Receptor - Endocytic Pathway (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32561", "l": "diphosphate + gamma-terpinene => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685242", "l": "CHEK1 phosphorylates BRCA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42636", "l": "AH2 + L-cysteine + Mo-molybdopterin = A + H2O + L-alanine + thio-Mo-molybdopterin", "d": []}, {"i": "EC:2.8.1.9", "l": "\"molybdenum cofactor sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186771", "l": "RNF111 binds SMAD7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65920", "l": "L-kynurenine + pyruvate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10334", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA => a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73063", "l": "H(+)(out) + Mn(2+)(in) = H(+)(in) + Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11889", "l": "an aldehyde + H2O + NADP(+) => a carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036401", "l": "pyrokinin receptor activity", "d": ["Combining with a pyrokinin and transmitting the signal within the cell to induce a change in cell activity. Pyrokinins are a group of insect neuropeptides that share the common C-terminal pentapeptide sequence Phe-X-Pro-Arg-Leu-NH2 (X = S, T, K, A, or G). They play a central role in diverse physiological processes including stimulation of gut motility, production and release of sex pheromones, diapause, and pupariation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090633", "l": "keto-deoxynonulosonic acid (KDN) cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + KDN = diphosphate + CMP-KDN."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30653", "l": "allantoin + CO2 + H2O2 => 2 H2O + O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39311", "l": "(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35169", "l": "minocycline(out) => minocycline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433418", "l": "Phosphorylation of JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0003991", "l": "acetylglutamate kinase activity", "d": ["Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0031679", "l": "NADH dehydrogenase (plastoquinone) activity", "d": ["Catalysis of the reaction: NADH + H+ + plastoquinone = NAD+ + plastoquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69914", "l": "adenosine(out) + 2 Na(+)(out) <=> adenosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54994", "l": "2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+) => 3 A + FMN + H2O + L-glutamate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25348", "l": "D-tyrosyl-tRNA(Tyr) + H2O => D-tyrosine + tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55350", "l": "9-cis-retinol => all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682026", "l": "MRN bound to shortened telomeres activates ATM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964311", "l": "G alpha (i):GTP binds SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443439", "l": "c-Src binds Raf1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098608", "l": "methylselenol demethylase activity", "d": ["Catalysis of the reaction: methylselenol + H2O => H2Se + CH3OH."]}, {"i": "REACT:R-HSA-2408530", "l": "MeSeH is hydrolysed to H2Se by methylselenol demethylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33335", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72857", "l": "ADP(in) + dADP(out) => ADP(out) + dADP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45186", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928657", "l": "MMP2,9 cleave EPHB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18029", "l": "2 ATP + hydrogencarbonate + NH4(+) = 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate", "d": []}, {"i": "EC:6.3.4.16", "l": "\"carbamoyl-phosphate synthase (ammonia)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53782", "l": "beta-muricholoyl-CoA + lithocholate => beta-muricholate + lithocholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22696", "l": "AH2 + androst-4-ene-3,17-dione + O2 = A + H2O + testololactone", "d": []}, {"i": "EC:1.14.99.12", "l": "\"androst-4-ene-3,17-dione monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45834", "l": "3-oxodecanoyl-CoA + H(+) + NADH => (3R)-3-hydroxydecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23989", "l": "(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate => (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39124", "l": "(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69756", "l": "Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31247", "l": "H(+) + prop-2-ynal + pyrroloquinoline quinol = prop-2-yn-1-ol + pyrroloquinoline quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39306", "l": "(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA <=> (2E,11Z,14Z)-eicosatrienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419334", "l": "Melatonin receptors can bind melatonin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58442", "l": "3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine => N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41687", "l": "1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O <=> 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12414", "l": "(R)-glycerate + phosphate => (2R)-3-phosphoglycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814096", "l": "ARL1:GTP binds SCOC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977375", "l": "CR1 binds C3bBb/C4bC2a (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75488", "l": "dehydroepiandrosterone 3-sulfate(out) + n H(+)(out) => dehydroepiandrosterone 3-sulfate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20824", "l": "adenosine + ATP = ADP + AMP + H(+)", "d": []}, {"i": "EC:2.7.1.20", "l": "\"adenosine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10532", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan", "d": []}, {"i": "EC:4.2.1.20", "l": "\"tryptophan synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421197", "l": "adenylosuccinate => adenosine 5'-monophosphate (AMP) + fumarate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218832", "l": "CDC42:GTP binds PAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22108", "l": "L-threonine = 2-oxobutanoate + NH4(+)", "d": []}, {"i": "EC:4.3.1.19", "l": "\"threonine ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.21", "l": "\"1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64187", "l": "H2O + N-(9Z-octadecenoyl)-L-tyrosine <=> (9Z)-octadecenoate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33623", "l": "ATP + CoA + dodecanoate = AMP + diphosphate + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75300", "l": "NAD(+) => 2'cADPR + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65208", "l": "(3S)-3-hydroxybutanoyl-CoA + H2O = (S)-3-hydroxybutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048502", "l": "ABC-type thiamine transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiamine(out) = ADP + H+ + phosphate + thiamine(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936378", "l": "Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73370", "l": "D-xylose(out) + 2 Na(+)(out) <=> D-xylose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16059", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58436", "l": "4-methylpentan-1-ol + NADP(+) = 4-methylpentanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102784", "l": "lutein oxygenase activity", "d": ["Catalysis of the reaction: lutein + 2 O2 = 3-hydroxy-beta-ionone + 3-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62061", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4341048", "l": "SUMOylation of RXRA with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69891", "l": "Na(+)(out) + thymidine(out) = Na(+)(in) + thymidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49451", "l": "beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O <=> alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58229", "l": "L-asparaginyl-[protein] + NAD(+) => H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31326", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose <=> (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443439", "l": "c-Src binds Raf1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250220", "l": "Homodimerization of ERBB4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75017", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hexadecanoyloxy-octadecanoate => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40028", "l": "9alpha-copalyl diphosphate + H2O => (13S)-vitexifolin A + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17249", "l": "2 Fe(2+) + 2 H2O + H2O2 = 6 H(+) + 2 iron(III) oxide-hydroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791109", "l": "GADD45A binds PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49012", "l": "aurachin C + H(+) + NADH + O2 = aurachin C epoxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868340", "l": "CDK5:p25 phosphorylates lamin B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757256", "l": "MCM3 binds MCM5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20630", "l": "H2O + O-phospho-L-seryl-[protein] => L-seryl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030698", "l": "5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from 5,10-methylenetetrahydrofolate to the C5 atom of the uridine residue at position 54 in a tRNA molecule. This occurs in most Gram-positive bacteria and some Gram-negative bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48008", "l": "2-hydroxybenzoyl-CoA + H(+) + NADH + O2 = 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.209", "l": "\"salicyloyl-CoA 5-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388809", "l": "CTLA-4 binds B7-1/B7-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349455", "l": "Phosphorylation of MDM4 by ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200952", "l": "Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36906", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783880", "l": "PIPOX oxidises PPCA to P6C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65573", "l": "(-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] => (-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26405", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) = H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0008940", "l": "nitrate reductase activity", "d": ["Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38830", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45485", "l": "H(+) + pyruvate => acetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43802", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37213", "l": "guanosine 2'-monophosphate + H(+) => 2',3'-cyclophospho-GMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69304", "l": "(Z)-glucotropeolin + H2O = (Z)-phenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74268", "l": "n H(+)(out) + spermidine(in) => n H(+)(in) + spermidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18123", "l": "a thiol + NH4(+) + pyruvate => an S-substituted L-cysteine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67216", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA = (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102046", "l": "3,4-dichlorobenzoate-4,5-oxygenase activity", "d": ["Catalysis of the reaction: 3,4-dichlorobenzoate + O2 + a reduced electron acceptor <=> 3,4-dichlorobenzoate-cis-4,5-diol + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798044", "l": "BTG2 binds CCR4-NOT complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34910", "l": "molybdate(in) <=> molybdate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443831", "l": "14-3-3-zeta binds Raf1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46367", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26190", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP => 1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0072349", "l": "modified amino acid transmembrane transporter activity", "d": ["Enables the transfer of modified amino acids from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75484", "l": "estrone 3-sulfate(out) + n H(+)(out) => estrone 3-sulfate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5444511", "l": "Formation of MSH2:MSH3 Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.91", "l": "\"sphingosine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004795", "l": "threonine synthase activity", "d": ["Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13177", "l": "6-phospho-5-dehydro-2-deoxy-D-gluconate = 3-oxopropanoate + dihydroxyacetone phosphate", "d": []}, {"i": "EC:4.1.2.29", "l": "\"5-dehydro-2-deoxyphosphogluconate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59624", "l": "H2O + N(2)-(4-aminobutanoyl)-L-ornithine = 4-aminobutanoate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43554", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34558", "l": "a (2S)-2-hydroxycarboxylate + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45849", "l": "(3R)-3-hydroxydodecanoyl-CoA + NADP(+) => 3-oxododecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62808", "l": "H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004090", "l": "carbonyl reductase (NADPH) activity", "d": ["Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35668", "l": "a triacylglycerol + H2O => a 1,2-diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17413", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349520", "l": "Re-acidification of acetylcholine transport vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015386", "l": "potassium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in)."]}, {"i": "RHEA:29467", "l": "H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847977", "l": "FRK phosphorylates PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2509827", "l": "ITPA hydrolyses ITP to IMP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2214351", "l": "PLK1 phosphorylates GORASP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050254", "l": "rhodopsin kinase activity", "d": ["Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61040", "l": "(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] = (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33795", "l": "H2O + sucrose = alpha-D-glucose + beta-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64496", "l": "3,5,7,9,11-pentaoxododecanoyl-[ACP] = 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45021", "l": "L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158860", "l": "SULT1A1 dimer sulfonates NHABP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002466", "l": "Formation of allysine by LOX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41125", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-434650", "l": "MATEs mediate extrusion of xenobiotics (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22366", "l": "3-dehydroquinate + H(+) + NADH => L-quinate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59040", "l": "4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65485", "l": "hexan-1-ol + hexanoyl-CoA => CoA + hexyl hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20012", "l": "2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose <=> H(+) + linamarin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71519", "l": "uridine(out) = uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19865", "l": "4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III", "d": []}, {"i": "EC:4.1.1.37", "l": "\"uroporphyrinogen decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16878", "l": "3-sulfino-L-alanine + H(+) => CO2 + hypotaurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65155", "l": "(2S)-naringenin + UDP-alpha-D-glucose <=> (2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928604", "l": "SFKs phosphorylate VAV2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43827", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56598", "l": "(1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O => (1S,4S)-bornane-2,5-dione + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709098", "l": "DHFR dimer reduces FOLA to DHF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067659", "l": "Assembly of hexameric IL-6 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.17", "l": "\"non-stereospecific dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660819", "l": "ADORA2B:Ade-Rib:GsGTP dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16261", "l": "L-lysyl-[protein] + succinyl-CoA = CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35020", "l": "L-threonine(in) => L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14373", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31679", "l": "O2 + prosolanapyrone II = H2O2 + prosolanapyrone III", "d": []}, {"i": "EC:1.1.3.42", "l": "\"prosolanapyrone-II oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853793", "l": "p-5Y-RET complexes bind GRB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55185", "l": "2-oxoglutarate + 3-methylundecanoyl-CoA + O2 => 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15743", "l": "2,5-dichlorohydroquinone + H(+) + NADH => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5681987", "l": "LC3 is cleaved by ATG4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026531", "l": "p-Y817 of p-5Y-NTRK2 recruits PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "64.598265520774746", "identifiers": [{"i": "GO:0016903", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12212", "l": "9H-fluoren-9-ol + NADP(+) = 9H-fluoren-9-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70982", "l": "Fumarate + H2O <=> (S)-Malate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16663", "l": "5'-deoxy-5'-fluoroadenosine + L-methionine => fluoride + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67129", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH => (1R,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26406", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) => H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953111", "l": "E2F6 binds TFDP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623806", "l": "Defective SLC12A6 does not cotransport K+, Cl- from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102950", "l": "indole-3-acetyl-valine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-valine + ATP = H+ + indole-3-acetyl-valine + AMP + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19938", "l": "glycine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2870221", "l": "E-selectin binds E-selectin ligand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917693", "l": "ESCRT Disassembly (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27527", "l": "(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-farnesol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54901", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADH => hexadecanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.52", "l": "\"indoleamine 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706336", "l": "Active FLT3 binds to SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75690", "l": "ATP(in) <=> ATP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868236", "l": "BAR domain proteins recruit dynamin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42580", "l": "ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50876", "l": "a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH = a hydroxy polyunsaturated fatty acid + H2O + NADP(+)", "d": []}, {"i": "EC:1.11.1.22", "l": "\"hydroperoxy fatty acid reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804425", "l": "TP53 binds POU4F2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57617", "l": "dihydro-ML-236C-[compactin nonaketide synthase] + H2O => dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27924", "l": "4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-500717", "l": "Activation of GRIK3 homomer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54120", "l": "coelenterazine h + O2 = coelenterazine h dioxetanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58696", "l": "NADPH + O2 + rifampicin = H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044730", "l": "bone sialoprotein binding", "d": ["Binding to a bone sialoprotein, an extracellular matrix glycoprotein found on the surface of bones and dentin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42432", "l": "3-hydroxy-cis,cis-muconate = maleylacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709317", "l": "CO binds to free ferrohemoglobin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71783", "l": "MDH2 reduces OA to MAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433542", "l": "Phosphorylation and activation of VAV1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396007", "l": "IRF3 is phosphorylated by TBK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28630", "l": "O2 + reduced [NADPH--hemoprotein reductase] + solavetivol <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16781", "l": "a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.20", "l": "\"acyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23722", "l": "(S)-methylmalonyl-CoA + ADP + H(+) + phosphate => ATP + hydrogencarbonate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014294", "l": "RAC2 binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65777", "l": "chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604732", "l": "Autocatalytic activation of proMMP13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654425", "l": "Activated FGFR4 binds SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42611", "l": "a plastoquinone + (n+1) H(+)(in) + NADH <=> a plastoquinol + n H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371422", "l": "ATP hydrolysis by HSP70 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37926", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23903", "l": "cis-stilbene oxide + H2O <=> (1R,2R)-hydrobenzoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692755", "l": "CDK1 phosphorylates MAPK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40403", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16198", "l": "(3S)-3-hydroxybutanoyl-CoA + NADP(+) => acetoacetyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34074", "l": "trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004441", "l": "inositol-1,4-bisphosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14145", "l": "ATP + guanidinoacetate = ADP + H(+) + phosphoguanidinoacetate", "d": []}, {"i": "EC:2.7.3.1", "l": "\"guanidinoacetate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41571", "l": "aclacinomycin T + dTDP-2-deoxy-beta-L-fucose <=> aclacinomycin S + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34703", "l": "(2E,6E)-farnesyl diphosphate = (E)-2-epi-beta-caryophyllene + diphosphate", "d": []}, {"i": "EC:4.2.3.137", "l": "\"(E)-2-epi-beta-caryophyllene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70163", "l": "H(+)(in) + methotrexate(in) = H(+)(out) + methotrexate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611147", "l": "Endocytic Uptake of HCMV Virion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59283", "l": "L-asparagine <=> D-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177920", "l": "Binding of GRB2 to GAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5226999", "l": "ADD1:ADD3 binds DMTN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26187", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O <=> 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672980", "l": "Dissociation of RAS:RAF complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675431", "l": "PP2A dephosphorylates RAF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48143", "l": "2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983285", "l": "RAD51B binds RAD51C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43055", "l": "3-(methylsulfanyl)propanoate + ATP + CoA <=> 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52334", "l": "3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin] => 2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45736", "l": "(3E)-hexenoyl-CoA = (2E)-hexenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75470", "l": "ethanolamine(out) + n H(+)(in) <=> ethanolamine(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043906", "l": "Ala-tRNA(Pro) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Ala-tRNA(Pro)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17376", "l": "all-trans-antheraxanthin <=> all-trans-capsanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676595", "l": "TRAFs bind RANK:RANKL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990380", "l": "K48-linked deubiquitinase activity", "d": ["Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35053", "l": "N,N'-diacetylchitobiose(in) => N,N'-diacetylchitobiose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.5.2", "l": "\"proline dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18017", "l": "H(+) + indole-3-pyruvate = CO2 + indole-3-acetaldehyde", "d": []}, {"i": "EC:4.1.1.74", "l": "\"indolepyruvate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11826", "l": "(6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203774", "l": "Interaction of Csk with PAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10566", "l": "H(+) + methanol + oxaloacetate => H2O + oxaloacetate 4-methyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9718360", "l": "GNRHR binds GNRHR peptide agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731123", "l": "Syndecan-1 binds Integrin alphaVbeta3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140839", "l": "RNA polymerase II CTD heptapeptide repeat P3 isomerase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 3) = RNA polymerase II large subunit trans-proline (omega=0) (position 3)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20228", "l": "(E)-caffeate + S-adenosyl-L-methionine <=> (E)-ferulate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2559439", "l": "CD14:LPS binds CR3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53831", "l": "2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 <=> a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29457", "l": "D-serine(out) => D-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2214351", "l": "PLK1 phosphorylates GORASP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373730", "l": "Neurofascin and NrCAM heterodimerization (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375160", "l": "NCAM1 binds to ATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62304", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine = (+)-premalbrancheamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52816", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53860", "l": "7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+) = dehydrocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23674", "l": "3-dehydroquinate + a quinol => a quinone + L-quinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018502", "l": "2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity", "d": ["Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449087", "l": "CD4 binds Interleukin-16 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156930", "l": "GTP-binding activates eEF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63987", "l": "5-hydroxyuridine + ATP <=> 5-hydroxyuridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008965", "l": "phosphoenolpyruvate-protein phosphotransferase activity", "d": ["Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38133", "l": "1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944262", "l": "Association of procollagen type X (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50997", "l": "L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696997", "l": "USP24 deubiquitinates DDB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418925", "l": "ADORA2A,B bind Ade-Rib (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14536", "l": "creatinine + H2O <=> creatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59952", "l": "2,6-dimethylheptanoyl-CoA + H2O = 2,6-dimethylheptanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22671", "l": "2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> H(+) + lipid A disaccharide (E. coli) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54450", "l": "a tRNA + an N-acyl-L-amino acid + H(+) => an N-acyl-L-alpha-aminoacyl-tRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814695", "l": "PERP binds desmosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008437", "l": "thyrotropin-releasing hormone activity", "d": ["The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62513", "l": "2-oxoglutarate + melatonin + O2 => 2-hydroxymelatonin + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52681", "l": "acetyl-CoA + L-alpha-phenylglycine => CoA + H(+) + N-acetyl-L-alpha-phenylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70830", "l": "L-arginine(in) + L-lysine(out) <=> L-arginine(out) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-688137", "l": "RIP2 is K63 polyubiquitinated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015090", "l": "low-affinity ferric iron ion transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) = Fe2+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21572", "l": "3-hydroxy-2-methyl-1H-quinolin-4-one + O2 = CO + H(+) + N-acetylanthranilate", "d": []}, {"i": "EC:1.13.11.48", "l": "\"3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32121", "l": "GDP + H(+) + validoxylamine A 7'-phosphate => GDP-valienol + validamine 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64277", "l": "chrysophanol-9-anthrone + O2 => chrysophanol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657767", "l": "Expression of APOD regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35708", "l": "(2S)-versicolorone + H(+) + NADPH + O2 => (3S)-versiconol acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46222", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + NADH => androst-5-en-3beta,17beta-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018527", "l": "cyclohexylamine oxidase activity", "d": ["Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56166", "l": "(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761858", "l": "NFE2L2-dependent TALDO1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75643", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050484", "l": "GMP 5'-nucleotidase activity", "d": ["Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51184", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + H2O = H(+) + octadecanoate + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000309", "l": "nicotinamide-nucleotide adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.51", "l": "\"ophiolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6803890", "l": "SFN dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73845", "l": "a sterol 27-beta-D-glucoside + H(+) + UDP => a 27-hydroxysterol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60728", "l": "citral + H2O + NADP(+) = 3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15472", "l": "1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide <=> 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395320", "l": "Latent TGF-beta-1 binds integrins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391866", "l": "Phosphorylation of FAK by Src kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734745", "l": "Defective ADA does not deaminate (deoxy)adenosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199425", "l": "PHLPP dephosphorylates S473 in AKT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879594", "l": "SLCO4C1 mediates the transport of digoxin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381446", "l": "Thrombin proteolyzes IGF:IGFBP3:ALS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34207", "l": "3-O-alpha-D-glucosyl-L-rhamnose + phosphate = beta-D-glucose 1-phosphate + L-rhamnopyranose", "d": []}, {"i": "EC:2.4.1.282", "l": "\"3-O-alpha-D-glucosyl-L-rhamnose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15802", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29123", "l": "nitrate(out) + ubiquinol-8(in) = H2O(out) + nitrite(out) + ubiquinone-8(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204813", "l": "Interaction of Tie2 and Grb14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106277", "l": "biliverdin reductase (NADP+) activity", "d": ["Catalysis of the reaction: bilirubin + NADP+ = biliverdin + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0022821", "l": "solute:potassium antiporter activity", "d": ["Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20456", "l": "scopoletin + UDP-alpha-D-glucose <=> H(+) + scopolin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63342", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate => ATP + L-amino acyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17363", "l": "H(+) + malonate + urea => 3-oxo-3-ureidopropanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15133", "l": "H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31656", "l": "4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O => 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809680", "l": "MTMR12 binds MTM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909755", "l": "Mitochondrial uptake of (R)-3-aminoisobutyric acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20590", "l": "glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52385", "l": "L-glutamate + O-phospho-L-serine => H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734475", "l": "PPARA binds fibrates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19118", "l": "dopamine + 2 L-ascorbate + O2 => (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166214", "l": "FA anion flip-flops to the opposite surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35057", "l": "(2E,4E)-2,5-dichloromuconate + H(+) => 3,6-dichlorocatechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781922", "l": "USP13 binds UFD1L:SKP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55474", "l": "9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68737", "l": "ganoderate TR + O2 + reduced [NADPH--hemoprotein reductase] => ganoderate Jc + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50371", "l": "2-methylbutan-2-ol + H(+) + NADPH + O2 <=> 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56838", "l": "5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine => [PQQ precursor protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47878", "l": "ganglioside GM1 + N-acetylneuraminate => ganglioside GD1b + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0004806", "l": "triglyceride lipase activity", "d": ["Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21081", "l": "ATP + H2O + L-methionine => diphosphate + phosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41898", "l": "NADP(+) + tetradecanoyl-[ACP] => (2E)-tetradecenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-383190", "l": "HCO3- transport through ion channel (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709547", "l": "ESTG binds ESR2:chaperone complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980065", "l": "NOTCH1 stimulates HEY transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70862", "l": "L-asparagine(in) + L-glutamine(out) + Na(+)(out) <=> L-asparagine(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008689", "l": "3-demethylubiquinone-9 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70056", "l": "AH2 + cremeomycin => 2-hydroxy-4-methoxybenzoate + A + N2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031754", "l": "Edg-1 sphingosine 1-phosphate receptor binding", "d": ["Binding to an Edg-1 sphingosine 1-phosphate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.104", "l": "\"3-dehydro-4-phosphotetronate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27906", "l": "butanoyl-CoA + NADP(+) = (2E)-butenoyl-CoA + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.86", "l": "\"crotonyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23498", "l": "5-hydroxy-pentanoyl-CoA + acetate => 5-hydroxypentanoate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21293", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296309", "l": "HCAR3 binds HCAR3 ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180573", "l": "Degradation of ubiquitinated CD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114544", "l": "p115-RhoGEF activation of RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.279", "l": "\"trans-anol O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0080084", "l": "5S rDNA binding", "d": ["Binding to a 5S rDNA sequence, encoding ribosomal 5S rRNA, which is individually transcribed by RNA polymerase III, rather than by RNA polymerase I, in species where it exists."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693536", "l": "ATM phosphorylates MDC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928615", "l": "EFNBs bind SFKs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25864", "l": "H2O + N(1)-acetylspermidine + O2 = 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24137", "l": "3'-phosphoadenylyl sulfate + a primary amine => a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46261", "l": "an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22345", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA => (R)-rosmarinate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63525", "l": "2-propylphenol + H(+) + NADH + O2 => 3-propylcatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71106", "l": "L-methionine(in) + S-methylmercury-L-cysteine(out) <=> L-methionine(out) + S-methylmercury-L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619669", "l": "L-PRX dimer binds DRP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654748", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50115", "l": "octadecanoyl-CoA + taurine <=> CoA + H(+) + N-octadecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63286", "l": "8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67360", "l": "H2O + L-threonyl-L-threonine = 2 L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21660", "l": "benzaldehyde + H2O + NADP(+) = benzoate + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.7", "l": "\"benzaldehyde dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696131", "l": "AOC1 deaminates Hist (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102498", "l": "maltose glucosidase activity", "d": ["Catalysis of the reaction: H2O + maltose = 2 glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141341", "l": "SMOX-3 oxidises SPN to SPM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004864", "l": "protein phosphatase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a protein phosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43420", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17485", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090632", "l": "N-glycolylneuraminic acid (Neu5Gc) cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + Neu5Gc = diphosphate + CMP-Neu5Gc."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102456", "l": "cyanidin 3-O-glucoside 5-O-glucosyltransferase (sinapoyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-sinapoyl-beta-D-glucose <=> cyanin betaine + trans-sinapate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671993", "l": "CIT-3 binds DLG4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19490", "l": "dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide => 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67686", "l": "a long-chain fatty acid(out) + ADP + H(+) + phosphate => a long-chain fatty acid(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75580", "l": "A + cyathatriol => AH2 + cyathin A3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10833", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O => 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102527", "l": "8-demethylnovobiocate synthase activity", "d": ["Catalysis of the reaction: 3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP(4-) <=> H+ + 8-desmethylnovobiocic acid(1-) + AMP(2-) + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25727", "l": "N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17801", "l": "acetyl-CoA + L-phenylalanine = CoA + H(+) + N-acetyl-L-phenylalanine", "d": []}, {"i": "EC:2.3.1.53", "l": "\"phenylalanine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443439", "l": "c-Src binds Raf1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33524", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O => acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418553", "l": "cAMP degradation by Phosphodiesterases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021596", "l": "Membrane estrogen receptors bind SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250947", "l": "B-WICH complex binds rDNA promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651773", "l": "LIG1 binds POLB at long-patch BER site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11410", "l": "lumichrome + ribitol => H(+) + H2O + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30685", "l": "H(+) + N-acetyl-D-mannosamine + UDP => H2O + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106316", "l": "nitrite reductase NADH activity", "d": ["Catalysis of the reaction: ammonium hydroxide + 3 NAD+ + H2O = nitrite + 3 NADH + 3 H+."]}, {"i": "RHEA:24628", "l": "2 H2O + 3 NAD(+) + NH4(+) = 5 H(+) + 3 NADH + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45015", "l": "H2O + N-octadecanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950586", "l": "Expression of glutathione S-transferase alpha 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710254", "l": "GSDME oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.3", "l": "\"gastricsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034957", "l": "3-nitrophenol nitroreductase activity", "d": ["Catalysis of the reaction: 3-nitrophenol + 2 NADH + 2 H+ = 3-hydroxyaminophenol + 2 NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46151", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> a 2'-deoxyribonucleoside + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48708", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol = a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706312", "l": "Active FLT3 binds to LCK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086086", "l": "voltage-gated potassium channel activity involved in AV node cell action potential repolarization", "d": ["Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809309", "l": "MTMR6 binds MTMR9 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50926", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975040", "l": "KRAB-ZNF / KAP Interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671993", "l": "CIT-3 binds DLG4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14737", "l": "CTP = 3',5'-cyclic CMP + diphosphate", "d": []}, {"i": "EC:4.6.1.6", "l": "\"cytidylate cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166387", "l": "The FA anion diffuses away laterally from UCP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617848", "l": "CDKN1B gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71177", "l": "2 chloride(in) + glycine betaine(in) + 3 Na(+)(in) => 2 chloride(out) + glycine betaine(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22485", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate => GMP + GTP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2995334", "l": "COX15 transforms heme O to heme A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55494", "l": "ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33347", "l": "2-iminoacetate + H2O = glyoxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37880", "l": "methyl aklanonate => aklaviketone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47064", "l": "4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36790", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine <=> N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624954", "l": "INPP5E translocates to the primary cilium (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030738", "l": "tyramine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = N-methyltyramine + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27378", "l": "(R)-glycerate + ATP => (2R)-2-phosphoglycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55268", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate = (R)-glycerate + alpha-D-glucose 1-phosphate", "d": []}, {"i": "EC:2.4.1.352", "l": "\"glucosylglycerate phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620723", "l": "VGF gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000277", "l": "[cytochrome c]-lysine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10020", "l": "H2O + L-saccharopine + NADP(+) = (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH", "d": []}, {"i": "EC:1.5.1.10", "l": "\"saccharopine dehydrogenase (NADP(+), L-glutamate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35132", "l": "H(+)(out) + L-alanyl-L-glutamate(out) => H(+)(in) + L-alanyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76031", "l": "2 H2O2 => O2 + 2 H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2574845", "l": "AJUBA binds centrosome-associated AURKA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987043", "l": "IL22RA1 binds JAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73164", "l": "FAD(out) + NAD(+)(in) => FAD(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177923", "l": "Sustained activation of SRC kinase by SHP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46974", "l": "AH2 + bisanhydrobacterioruberin => A + dihydrobisanhydrobacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.196", "l": "\"L-ornithine N(5)-monooxygenase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111966", "l": "GRK2 binds CALM1:4Ca2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62758", "l": "4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53476", "l": "1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201622", "l": "Caspase-mediated cleavage of gelsolin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12604", "l": "2-oxoglutarate + L-2-aminoadipate <=> 2-oxoadipate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37696", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA => 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60525", "l": "5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine => 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-435244", "l": "PECAM1 is phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953398", "l": "PIR oxygenates quercetin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710254", "l": "GSDME oligomerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68533", "l": "(2E,6E)-farnesyl diphosphate => (Z)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10110", "l": "H(+) + NADPH + salutaridine => (7S)-salutaridinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60189", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42804", "l": "5,6,7,8-tetrahydromethanopterin + A = 7,8-dihydromethanopterin + AH2", "d": []}, {"i": "EC:1.5.99.15", "l": "\"dihydromethanopterin reductase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51399", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin <=> CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178189", "l": "SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10859", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose <=> a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430190", "l": "p-SLP-76 binds NCK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71849", "l": "LDH tetramer reduces PYR to LACT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106140", "l": "P-TEFb complex binding", "d": ["Binding to a P-TEFb complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50050", "l": "ADP + cholate(out) + H(+) + phosphate => ATP + cholate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30976", "l": "15-cis-phytoene + 5 A => 5 AH2 + all-trans-3,4-didehydrolycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196929", "l": "FLAD1 phosphorylates FMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13250", "l": "(R)-2-hydroxypropyl-coenzyme M + NAD(+) => 2-oxopropyl-coenzyme M + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605724", "l": "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353494", "l": "Elongation by Pol kappa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005170", "l": "neurotrophin TRKC receptor binding", "d": ["Binding to a neurotrophin TRKC receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53982", "l": "(11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32266", "l": "4-aminobutanoate + pyruvate <=> L-alanine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11966", "l": "5alpha-cholestane-3beta,5,6beta-triol => 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43862", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57991", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside F2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.109", "l": "\"matriptase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265301", "l": "Corticotropin cleavage from POMC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450088", "l": "GLUT1 tetramer binds 4xATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22521", "l": "all-trans-retinal + H2O + O2 => all-trans-retinoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64860", "l": "(E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine = (E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52675", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate <=> [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19507", "l": "(indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP => indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5607746", "l": "PKC-delta is activated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168376", "l": "STIM1 oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034577", "l": "N-isopropylacetaniline monooxygenase activity", "d": ["Catalysis of the reaction: N-isopropylacetanilide + 1/2 O2 = acetanilide + acetone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16633", "l": "guanosine(34) in tRNA + queuine = guanine + queuosine(34) in tRNA", "d": []}, {"i": "EC:2.4.2.64", "l": "\"tRNA-guanosine(34) queuine transglycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59014", "l": "24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine => cycloartenol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964914", "l": "DHQ from DAHP dephosphorylation (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23898", "l": "3-deoxy-D-glycero-2,5-hexodiulosonate => 5-dehydro-4-deoxy-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610752", "l": "GLI3R translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2314566", "l": "GORASP1 phosphorylated by PLK1 and GORASP2 phosphorylated by MAPK3-3/MAPK1 are unable to promote Golgi cisternae stacking (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809309", "l": "MTMR6 binds MTMR9 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-435375", "l": "ZnT2 facilitates zinc vesicular sequestration (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56434", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59488", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139893", "l": "Granzyme-B activates BID by cleavage (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70910", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-mannose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981610", "l": "Neuroglobin binds oxygen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9761474", "l": "AMOT-2 binds CDH11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674385", "l": "p-T,Y MAPKs dimerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661230", "l": "MT1A binds arsenic (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22451", "l": "ATP + pseudouridine <=> ADP + H(+) + psi-UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44557", "l": "4-hydroxybenzoate + all-trans-hexaprenyl diphosphate => 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209973", "l": "Tyrosine is diiodinated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866854", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55816", "l": "a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649733", "l": "mature p21 RAS binds GDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27364", "l": "chloride + S-adenosyl-L-methionine <=> chloromethane + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014294", "l": "RAC2 binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40295", "l": "ATP + CoA + hexadecanedioate = AMP + diphosphate + hexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70656", "l": "H(+)(in) + sarcosine(in) => H(+)(out) + sarcosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097246", "l": "catechin binding", "d": ["Binding to a catechin, a polyphenolic antioxidant plant metabolite with a flavonoid or flavan-3-ol structure."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46163", "l": "a quinone + H(+) + NADH <=> a quinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42518", "l": "H(+) + L-gulonate => H2O + L-gulono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3785711", "l": "Telomere shortening during replicative exhaustion (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.156", "l": "\"oligosaccharide reducing-end xylanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682377", "l": "LC3 de-lipidation by ATG4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63386", "l": "1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine => 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016987", "l": "sigma factor activity", "d": ["Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61196", "l": "(E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25688", "l": "L-cysteinyl-tRNA(Cys) + phosphate => H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853405", "l": "TPX2 binds AURKA at centrosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854466", "l": "VLDLR binds RELN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49055", "l": "asperlicin C + H(+) + NADH + O2 <=> asperlicin E + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853745", "l": "RET binds GFRA1,GFRA3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16679", "l": "fluoroacetate + 2 H(+) + NADH => fluoroacetaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428990", "l": "Arachidonate diffuses across the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68273", "l": "a fatty acyl-CoA + L-seryl-[protein] => CoA + O-fatty acyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856945", "l": "PP2A methylation by LCMT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14056", "l": "D-arabinose 5-phosphate + H2O + phosphoenolpyruvate <=> 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62311", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) <=> (+)-malbrancheamide B + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62080", "l": "D-glucose 6-sulfate + NADP(+) = 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62351", "l": "H(+) + NADPH + notoamide E + O2 <=> H2O + NADP(+) + notoamide C", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047529", "l": "2,3-dimethylmalate lyase activity", "d": ["Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = propanoate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57074", "l": "CO2 + L-erythrulose 1-phosphate => 3-oxoisoapionate 4-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033506", "l": "TYSND1 cleaves AGPS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004318", "l": "enoyl-[acyl-carrier-protein] reductase (NADH) activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29677", "l": "glycerol(out) => glycerol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36081", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72813", "l": "L-arginine(in) + N(omega),N(omega)-dimethyl-L-arginine(out) => L-arginine(out) + N(omega),N(omega)-dimethyl-L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3785711", "l": "Telomere shortening during replicative exhaustion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199456", "l": "PTEN dephosphorylates PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672817", "l": "Active MTORC1 binds the ULK1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51703", "l": "S-adenosyl-L-methionine + xanthogalenol <=> 4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18258", "l": "coproporphyrinogen III + 2 H(+) + O2 => 2 CO2 + 2 H2O + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9773208", "l": "CDH19 gene expression is stimulated by SOX10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2464822", "l": "RDH12 reduces atRAL to atROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52829", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 => (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65919", "l": "L-kynurenine + pyruvate <=> H2O + kynurenate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41087", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031735", "l": "CCR10 chemokine receptor binding", "d": ["Binding to a CCR10 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677051", "l": "Formation of the PCAF-ATAC complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004979", "l": "beta-endorphin receptor activity", "d": ["Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9633044", "l": "ESR binds STRN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106142", "l": "rRNA (adenine-N1-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + adenine(645) in 25S rRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(645) in 25S rRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983259", "l": "Kinesins move along microtubules consuming ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667456", "l": "AVPR1A,B bind desmopressin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71222", "l": "2 Na(+)(out) + nitrate(out) <=> 2 Na(+)(in) + nitrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57632", "l": "ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634886", "l": "NPAS4 binds RBFOX3 (NeuN) gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008894", "l": "guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity", "d": ["Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2314678", "l": "ASA- acetylates PTGS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371518", "l": "SIRT1 binds to HSF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75200", "l": "H2O + triuret => 1-carboxybiuret + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031765", "l": "type 2 galanin receptor binding", "d": ["Binding to a type 2 galanin receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045505", "l": "dynein intermediate chain binding", "d": ["Binding to an intermediate chain of the dynein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19776", "l": "NADP(+) + sn-glycerol 3-phosphate <=> D-glyceraldehyde 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28009", "l": "H2O + N(alpha)-methyl-L-tryptophan + O2 <=> formaldehyde + H2O2 + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112436", "l": "Formation of Elongin complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2219524", "l": "PDPK1 binds PIP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63510", "l": "a (2R)-2-hydroperoxy fatty acid => a 1,2-saturated fatty acid + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14729", "l": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": []}, {"i": "EC:4.1.2.13", "l": "\"fructose-bisphosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-933533", "l": "Dimerization of p-IRF7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670620", "l": "Defective DAXX does not bind ATRX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169402", "l": "ISGylation of E2 conjugating enzymes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49575", "l": "Fe-coproporphyrin III + 2 H(+) <=> coproporphyrin III + Fe(2+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450488", "l": "BRF1 Complex recruits RNA degradation activities (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265301", "l": "Corticotropin cleavage from POMC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9633044", "l": "ESR binds STRN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050030", "l": "L-pipecolate dehydrogenase activity", "d": ["Catalysis of the reaction: L-pipecolate + acceptor = delta1-piperideine-6-carboxylate + reduced acceptor. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953037", "l": "E2F8 forms homodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172126", "l": "DAP12 interacts with NKG2C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052901", "l": "spermine:oxygen oxidoreductase (spermidine-forming) activity", "d": ["Catalysis of the reaction: H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47330", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) => 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939904", "l": "Activated ESR1 binds the RUNX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14922", "l": "(indol-3-yl)acetate + UDP-alpha-D-glucose => 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099108", "l": "potassium channel activator activity involved in G protein-coupled receptor signaling pathway", "d": ["Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15890", "l": "H2O + L-glutamine => L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21503", "l": "UDP-alpha-D-glucose <=> H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64482", "l": "(1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate => 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54529", "l": "aldehydo-D-ribose 5-phosphate => D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35787", "l": "paromamine + UDP-alpha-D-kanosamine = H(+) + kanamycin C + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8945709", "l": "miR-20 microRNAs bind PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69956", "l": "Ca(2+)(in) + 3 Na(+)(out) => Ca(2+)(out) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40906", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21069", "l": "A + H2O + nitrite => AH2 + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625324", "l": "FOXO1 binds SREBF1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40110", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60056", "l": "a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 = a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210292", "l": "Interaction of DAP12 and TREM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64367", "l": "prostaglandin G2 <=> (15S)-15-hydroperoxy-prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63649", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17591", "l": "H(+) + L-alanine + NADH + pyruvate => 2,2'-iminodipropanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63142", "l": "taurine + tetracosanoate => H2O + N-tetracosanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32559", "l": "(2E)-geranyl diphosphate = diphosphate + gamma-terpinene", "d": []}, {"i": "EC:4.2.3.114", "l": "\"gamma-terpinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12367", "l": "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) <=> a quinol + beta-nicotinamide D-riboside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39383", "l": "3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36685", "l": "CoA + S-hexadecanoyl-L-cysteinyl-[protein] => hexadecanoyl-CoA + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2529020", "l": "CK2 phosphorylates condensin I subunits (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58747", "l": "H2O + N(7)-methyl-GTP <=> diphosphate + H(+) + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30923", "l": "(R)-glycerate + ADP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)", "d": []}, {"i": "EC:2.4.1.268", "l": "\"glucosylglycerate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64203", "l": "an N-(fatty acyl)-L-leucine + H2O <=> a fatty acid + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41953", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69888", "l": "Na(+)(out) + uridine(out) => Na(+)(in) + uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800794", "l": "PIDD1 associates with CRADD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004878", "l": "complement component C5a receptor activity", "d": ["Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60723", "l": "(E)-hept-2-enal + H2O + NADP(+) <=> (E)-hept-2-enoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428750", "l": "Gq activation by TP receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101013", "l": "mechanosensitive voltage-gated sodium channel activity", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel whose activity is modulated in response to mechanical stress. Response to mechanical stress and voltage gating together is different than the sum of individual responses. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110215", "l": "Cleavage of uracil by UNG glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48602", "l": "[protein-PII]-L-tyrosine + H(+) + UMP => [protein-PII]-uridylyl-L-tyrosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193650", "l": "p75NTR binds to NADE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59056", "l": "2 methanethiol + NAD(+) = dimethyl disulfide + H(+) + NADH", "d": []}, {"i": "EC:1.8.1.21", "l": "\"dissimilatory dimethyldisulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033947", "l": "mannosylglycoprotein endo-beta-mannosidase activity", "d": ["Catalysis of the hydrolysis of the alpha-D-mannosyl-(1->6)-beta-D-mannosyl-(1->4)-beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequence of glycoprotein to alpha-D-mannosyl-(1->6)-D-mannose and beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequences."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102368", "l": "beta-amyrin 30-monooxygenase activity", "d": ["Catalysis of the reaction: beta-amyrin + NADPH + H+ + O2 <=> 30-hydroxy-beta-amyrin + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336184", "l": "GPR37L binds prosaposin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23201", "l": "H2O + N(6)-methyl-L-lysine + O2 => formaldehyde + H2O2 + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74742", "l": "Phosphorylation of SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654514", "l": "KAL1 binds FGFR1c (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114684", "l": "Phosphorylation of Syntaxin-4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23415", "l": "H2O + N-acetylputrescine <=> acetate + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047596", "l": "6-methylsalicylate decarboxylase activity", "d": ["Catalysis of the reaction: 6-methylsalicylate + H+ = 3-cresol + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70175", "l": "beta-D-glucosyl-(1->4)-D-galactose + phosphate = alpha-D-glucose 1-phosphate + D-galactose", "d": []}, {"i": "EC:2.4.1.388", "l": "\"glucosylgalactose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917696", "l": "Cargo Sequestration (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74910", "l": "(2E)-but-2-enoyl-AMP + holo-[ACP] <=> (2E)-butenoyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610720", "l": "PKA phosphorylates GLI3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37557", "l": "kanosamine + phosphate => D-kanosamine 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21184", "l": "a dolichyl phosphate + GDP-alpha-D-mannose = a dolichyl beta-D-mannosyl phosphate + GDP", "d": []}, {"i": "EC:2.4.1.83", "l": "\"dolichyl-phosphate beta-D-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76386", "l": "CYP1A2 S-demethylates 6MMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48485", "l": "a propanoate ester + H2O => an aliphatic alcohol + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55710", "l": "[ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide => [ADP-thiazole synthase]-L-cysteine + glycine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197770", "l": "STAB1 (FEEL-1) binds ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2545203", "l": "Deacetylation of cleaved cohesin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52767", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O <=> (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55327", "l": "11-cis-retinol + hexadecanoyl-CoA <=> 11-cis-retinyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675206", "l": "PEA15 binds MAPK monomers and dimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43213", "l": "adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51198", "l": "chloride(in) + Na(+)(in) + serotonin(in) => chloride(out) + Na(+)(out) + serotonin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0050734", "l": "hydroxycinnamoyltransferase activity", "d": ["Catalysis of the transfer of a hydroxycinnamoyl group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48699", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O <=> H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55375", "l": "H2O + methyl (-)-jasmonate <=> H(+) + jasmonate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63347", "l": "ATP + L-amino acyl-L-threonyl-[protein] <=> (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69209", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ATP + L-glutamate => (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26337", "l": "L-homocysteine + S-methyl-L-methionine = H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48477", "l": "ganglioside GT1a (d18:1(4E)) + H2O => ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008880", "l": "glucuronate isomerase activity", "d": ["Catalysis of the reaction: D-glucuronate = D-fructuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24187", "l": "4,5-dihydroxyphthalate + H(+) <=> 3,4-dihydroxybenzoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.42", "l": "\"complement subcomponent C1s\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102653", "l": "gibberellin A51,2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A51 + 2-oxoglutarate + O2 <=> H+ + gibberellin A51-catabolite + succinate + carbon dioxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196753", "l": "2xPPCS ligates PPanK with Cys (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64927", "l": "dATP + 2 H2O <=> dAMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70501", "l": "D-galactose(in) + 2 Na(+)(in) => D-galactose(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24761", "l": "H(+) + L-dopa + NADH => 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69781", "l": "(2-oxoindol-3-yl)acetyl-CoA + succinate => 2-oxindole-3-acetate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008009", "l": "chemokine activity", "d": ["The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64899", "l": "2 H2O + UTP <=> 2 H(+) + 2 phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031177", "l": "phosphopantetheine binding", "d": ["Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614933", "l": "ACEIs bind ACE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65063", "l": "NADP(+) + taurochenodeoxycholate <=> 7-oxotaurolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33860", "l": "(2S-3S)-versiconal hemiacetal => H2O + versicolorin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617877", "l": "HOXA4 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23605", "l": "kievitone hydrate => H2O + kievitone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70840", "l": "L-arginine(in) + L-histidine(out) + Na(+)(out) => L-arginine(out) + L-histidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68980", "l": "NADP(+) + tauroursodeoxycholate = 7-oxotaurolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49831", "l": "(5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33641", "l": "AMP + diphosphate + tetracosanoyl-CoA => ATP + CoA + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.919848880058524", "identifiers": [{"i": "GO:0005253", "l": "monoatomic anion channel activity", "d": ["Enables the energy-independent passage of a monoatomic anion across a lipid bilayer down a concentration gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60482", "l": "c-di-UMP + 2 diphosphate => 2 UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72220", "l": "3 hydrogencarbonate(out) + Na(+)(out) => 3 hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57688", "l": "apo-[corrinoid adenosyltransferase] + cob(II)inamide = cob(II)inamide-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13472", "l": "A + H2O + thymine <=> 5-methylbarbiturate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34649", "l": "3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5622134", "l": "CRABP1 binds atRA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47936", "l": "4-hydroxybenzaldehyde + H2O + NADP(+) = 4-hydroxybenzoate + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.96", "l": "\"4-hydroxybenzaldehyde dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39385", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35590", "l": "FMN + H2O <=> phosphate + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380782", "l": "STAT binds to the active receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793451", "l": "MLKL binds ITCH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661625", "l": "FVIII is secreted (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58878", "l": "4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11876", "l": "NAD(+) + prostaglandin E2 = 15-oxoprostaglandin E2 + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.141", "l": "\"15-hydroxyprostaglandin dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14847", "l": "(S)-2,3-dihydrodipicolinate + H(+) + 2 H2O => L-aspartate 4-semialdehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354124", "l": "Phosphorylation of pPTK2 by SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55080", "l": "ADP-alpha-D-glucose + D-fructose = ADP + H(+) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71184", "l": "L-kynurenine(out) + L-tryptophan(in) => L-kynurenine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59377", "l": "4-amino-4-deoxychorismate => 4-amino-4-deoxyprephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35050", "l": "adenylyl-molybdopterin + H(+) + molybdate <=> AMP + H2O + Mo-molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696268", "l": "RND3 binds effectors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533874", "l": "Laminin-511 degradation by MMP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653936", "l": "Formation of Ragulator complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61098", "l": "(S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62670", "l": "H2O + herqueinone + NADP(+) => deoxyherqueinone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43442", "l": "H2O + N-hexadecanoylsphinganine => hexadecanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34972", "l": "Fe(3+)(in) => Fe(3+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008030", "l": "neuronal pentraxin receptor activity", "d": ["Combining with a neuronal pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443779", "l": "Linkage of L1 with treadmilling F-actin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39479", "l": "(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH = (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4615910", "l": "SUMOylation of PCNA with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36345", "l": "2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+) => 2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168640", "l": "Ubiquitinated IkB is degraded (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75688", "l": "ATP(in) => ATP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35964", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A => fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18328", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-amorpha-4,11-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14191", "l": "N-formyl-D-kynurenine => D-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102306", "l": "benzil reductase [(S)-benzoin-forming] activity", "d": ["Catalysis of the reaction: (S)-benzoin + NADP(3-) <=> benzil + NADPH(4-) + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034711", "l": "inhibin binding", "d": ["Binding to an inhibin monomer, any of the polypeptides that combine to form activin and inhibin dimers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61043", "l": "(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38383", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800798", "l": "The PIDDosome binds CASP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.207", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444208", "l": "MLNR (GPR38) is a receptor for motilin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67666", "l": "1,2-diacyl-sn-glycero-3-phosphoethanolamine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid => [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57772", "l": "3-nitrotoluene + NADH + O2 = 4-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249378", "l": "STING recruits TBK1 and STAT6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21570", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose => beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2400009", "l": "PI3K inhibitors block PI3K catalytic activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46079", "l": "(2E)-eicosenoyl-CoA + H(+) + NADH <=> eicosanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050137", "l": "NADPH peroxidase activity", "d": ["Catalysis of the reaction: H2O2 + H+ + NADPH = 2 H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74361", "l": "coproporphyrin I(in) => coproporphyrin I(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247849", "l": "WLS dissociates from retromer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22211", "l": "3-hydroxyphenylacetate + H(+) + NADH + O2 <=> H2O + homogentisate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726875", "l": "HCNs:cAMP bind SNIs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43119", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692867", "l": "HRH3 binds pitosilant (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63679", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814695", "l": "PERP binds desmosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31993", "l": "diphosphate + sesquithujene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672973", "l": "MAP2Ks phosphorylate MAPKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23525", "l": "1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol => an alkyl cinnamate + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033608", "l": "formyl-CoA transferase activity", "d": ["Catalysis of the reaction: formyl-CoA + oxalate = formate + oxalyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853391", "l": "GlcNAc (Man)5 translocates from cytosol to lysosomal lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665809", "l": "F8 variant does not bind von Willebrand factor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008927", "l": "mannonate dehydratase activity", "d": ["Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57262", "l": "GDP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5676229", "l": "WIPIs bind PI3P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9794475", "l": "Cipro:ALB dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17559", "l": "CoA + N-malonylanthranilate => anthranilate + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678998", "l": "Endosomal TLRs pass through the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3857336", "l": "CEBPB homodimerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57029", "l": "FADH2 + N-methylnicotinate + O2 => (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3318415", "l": "ATF2 acetylates histone H2B, H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68611", "l": "Formation of ORC(1-5) complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879674", "l": "CD97 binds CD55 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73328", "l": "(2R,3S)-piscidate + (E)-sinapoyl-CoA => cimicifugate J + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48836", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050501", "l": "hyaluronan synthase activity", "d": ["Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102276", "l": "2-oxoglutarate oxygenase/decarboxylase (ethylene-forming) activity", "d": ["Catalysis of the reaction: 2-oxoglutarate(2-) + O2 + 2 H+ <=> ethene + 3 carbon dioxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73806", "l": "AIR + CO2 => CAIR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54003", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013006", "l": "RHOA:GTP translocates to the ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42368", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.124", "l": "\"dihydromonacolin L hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381091", "l": "IRE1 dimer autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167234", "l": "Association of Tat with P-TEFb(Cyclin T1:Cdk9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849878", "l": "PSD-95 binds NMDA receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48073", "l": "ganglioside GM1 (d18:1(4E)) + H2O => ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37097", "l": "3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA => (10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805740", "l": "SETD8 methylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-191303", "l": "FDPS dimer transfers IPPP to GPP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25797", "l": "2-oxoglutarate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675194", "l": "Activated MAPK phosphorylates RAF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203567", "l": "palmitoylation of eNOS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928578", "l": "EPH receptors autophosphorylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13200", "l": "H(+) + sulfite + UDP-alpha-D-glucose <=> H2O + UDP-alpha-D-6-sulfoquinovose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9015111", "l": "Factor Xa inhibitors binds Xa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32443", "l": "all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.21", "l": "\"zeaxanthin epoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.88", "l": "\"L-glutamate gamma-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10986", "l": "(S)-malate + pyruvate => (S)-lactate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.39", "l": "\"hydroxyjasmonate sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2574845", "l": "AJUBA binds centrosome-associated AURKA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65548", "l": "ganglioside Fuc-GM1 + H2O = alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52642", "l": "(2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA => (2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990405", "l": "protein antigen binding", "d": ["Binding to a protein antigen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167419", "l": "The receptor:G-protein complex releases GDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374899", "l": "Release of noradrenaline  at the synapse (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72369", "l": "estrone 3-sulfate(in) + succinate(out) => estrone 3-sulfate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534378", "l": "Hv1 Mediated H+ Permeability (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19039", "l": "an ethanediol => an epoxide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805507", "l": "APAF1 binds AVEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42595", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39770", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59893", "l": "L-2-amino-4-chloropent-4-enoate => chloride + H(+) + L-propargylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13588", "l": "ATP + butanoate <=> ADP + butanoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619355", "l": "CaMKK autophosphorylates in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690740", "l": "CD22 binds B-cell receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169895", "l": "Crk's SH3 domain engages C3G (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209738", "l": "VD3 binds GC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38543", "l": "H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] = (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902052", "l": "(25S)-Delta(7)-dafachronate binding", "d": ["Binding to (25S)-Delta(7)-dafachronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047917", "l": "GDP-glucosidase activity", "d": ["Catalysis of the reaction: GDP-D-glucose + H2O = D-glucose + GDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14345", "l": "H(+) + L-tyrosine = CO2 + tyramine", "d": []}, {"i": "EC:4.1.1.25", "l": "\"tyrosine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809707", "l": "MTMR12 binds MTMR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43616", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}, {"i": "EC:2.7.7.80", "l": "\"molybdopterin-synthase adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63904", "l": "2 3-phenylpyruvate + H(+) = H2O + phenguignardate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854303", "l": "TBC1D11 binds RAB6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67143", "l": "L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2 <=> H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070097", "l": "delta-catenin binding", "d": ["Binding to the delta subunit of the catenin complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47829", "l": "ganglioside GT1b + H2O => ganglioside GD1b + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48675", "l": "20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420202", "l": "Secretin receptor binds secretin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813749", "l": "ALDH1A1 oxidises GA to DGA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38249", "l": "1-O-hexadecyl (9Z)-hexadecenoate + CoA => (9Z)-hexadecenoyl-CoA + hexadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32626", "l": "L-threo-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783455", "l": "TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64708", "l": "butan-1-ol + NADP(+) = butanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59045", "l": "dammarenediol-II + UDP-alpha-D-glucose => (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50201", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51317", "l": "(9Z)-octadecenoate + glycine => H2O + N-(9Z-octadecenoyl)glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592239", "l": "Expression of PEO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58428", "l": "(E,E)-2,4-hexadien-1-ol + NADP(+) = (E,E)-2,4-hexadienal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75850", "l": "Addition of the third nucleotide on the nascent transcript (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22074", "l": "ADP + H(+) + L-ribulose 5-phosphate => ATP + L-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218847", "l": "PAK2 binds NCK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74956", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + holo-[ACP] => a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45873", "l": "15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619657", "l": "EGR2 and SOX10 bind the PRX gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679266", "l": "Beclin-1 complex translocates to the ER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68603", "l": "ORC5 binds ORC2:ORC3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019134", "l": "glucosamine-1-phosphate N-acetyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucosamine 1-phosphate + acetyl-CoA = N-acetyl-alpha-D-glucosamine 1-phosphate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047519", "l": "quinate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: (-)-quinate + pyrroloquinoline-quinone = (-)-3-dehydroquinate + pyrroloquinoline-quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163320", "l": "Association of mTERF with the termination sequence (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029268", "l": "Phosphorylation and activation of PLCG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68932", "l": "ATP + H(+) + NADPH + octanoate = AMP + diphosphate + NADP(+) + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21237", "l": "anthranilate + 2 H(+) + NADPH + O2 => 2,3-dihydroxybenzoate + NADP(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21115", "l": "globoside Gb3Cer (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428625", "l": "Vesicular inhibitory amino acid transport (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23323", "l": "D-tryptophan + malonyl-CoA <=> CoA + H(+) + N(2)-malonyl-D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58119", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose <=> 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102441", "l": "syringetin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: syringetin(1-) + S-adenosyl-L-methionine <=> 7,3',5'-trimethylmyricetin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70330", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+) <=> 4-methylsulfanyl-2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10952", "l": "(E)-sinapoyl-CoA + hydroxymalonate = (E)-sinapoyltartronate + CoA", "d": []}, {"i": "EC:2.3.1.106", "l": "\"tartronate O-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15720", "l": "daunorubicin + H(+) + NADPH + O2 <=> doxorubicin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167084", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57638", "l": "holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate => (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9006850", "l": "IL21 receptor JAK phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16795", "l": "(R)-4'-phosphopantetheine + CO2 => H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050126", "l": "N-carbamoylputrescine amidase activity", "d": ["Catalysis of the reaction: N-carbamoylputrescine + H2O + 2 H+ = CO2 + NH4 + putrescine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54668", "l": "pre-alpha-onocerin = alpha-onocerin", "d": []}, {"i": "EC:5.4.99.66", "l": "\"alpha-onocerin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23483", "l": "2-methylene-3-methylsuccinate <=> dimethylmaleate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653894", "l": "Expression of CHAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55779", "l": "all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate <=> all-trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36699", "l": "3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP = 8-desmethylnovobiocic acid + AMP + diphosphate", "d": []}, {"i": "EC:6.3.1.15", "l": "\"8-demethylnovobiocic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69386", "l": "(3R)-4-(dimethylamino)-3-hydroxybutanoate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein] => (R)-carnitine + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15246", "l": "a monoacylglycerol + H2O => a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47472", "l": "(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH = (3E)-tetradecenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399969", "l": "AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17266", "l": "trans-aconitate => cis-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35713", "l": "acetyl-CoA + succinate => acetate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0070697", "l": "activin receptor binding", "d": ["Binding to an activin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18244", "l": "D-lysine <=> (2R,5S)-2,5-diaminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44348", "l": "ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate = ADP + dapdiamide B + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75010", "l": "H(+)(out) + VO(2+)(out) <=> H(+)(in) + VO(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34815", "l": "2 NADP(+) + tetrahydrocurcumin = curcumin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72204", "l": "2 chloride(out) + hydrogencarbonate(in) => 2 chloride(in) + hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31163", "l": "(3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445072", "l": "Interaction of PAK1 with Rac1-GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754964", "l": "ADA deamidates RBV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53384", "l": "5,10-methylenetetrahydromethanopterin + NAD(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050825", "l": "ice binding", "d": ["Binding to ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70074", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sitosterol <=> (22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62518", "l": "H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382061", "l": "Extracellular processing of novel PDGFs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44406", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-7 => 3-demethylubiquinol-7 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51977", "l": "an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23542", "l": "AMP + diphosphate + L-glutamyl-tRNA(Glu) => ATP + L-glutamate + tRNA(Glu)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102517", "l": "oleate 12-hydroxylase activity", "d": ["Catalysis of the reaction: oleoyl-CoA + NADH + O2 + H+ = ricinoleyl-CoA + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24382", "l": "(6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet) => (6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796626", "l": "MIB2 ubiquitinates CFLAR  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45498", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin alpha-subunit] => phycocyanobilin-L-cysteinyl(84)-[allophycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41495", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909552", "l": "Phosphorylation of STAT1 at Ser727 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944218", "l": "Association of procollagen type VIII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821368", "l": "AKAP8L binds MLL1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75344", "l": "adenosine(in) => adenosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36936", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72405", "l": "2-oxoglutarate(in) + urate(out) => 2-oxoglutarate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.14", "l": "\"nitric oxide reductase [NAD(P)(+), nitrous oxide-forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167150", "l": "Resumption of elongation of HIV-1 transcript after recovery from pausing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25859", "l": "(9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41946", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP => [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949301", "l": "RORC gene expression is stimulated by RUNX3:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54067", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-cubebol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42341", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) => 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953398", "l": "PIR oxygenates quercetin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799733", "l": "Semiquinone reacts with oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37474", "l": "3-methylbutanoyl-CoA + S-adenosyl-L-methionine <=> CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62635", "l": "a hydroperoxide + 2 glutathione <=> an alcohol + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36124", "l": "gibberellin A20 + S-adenosyl-L-methionine => gibberellin A20 methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015188", "l": "L-isoleucine transmembrane transporter activity", "d": ["Enables the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12492", "l": "L-methionine = D-methionine", "d": []}, {"i": "EC:5.1.1.2", "l": "\"methionine racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50116", "l": "eicosanoyl-CoA + taurine = CoA + H(+) + N-eicosanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788622", "l": "p-Y-STATs dimerize (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140850", "l": "histone H2B C-terminal K residue ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to a histone 2B at the conserved C-terminal lysine (K) residue. The last K residue is at position 119 in fission yeast, 123 in budding yeast, and 120 in mammals."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047999", "l": "hyponitrite reductase activity", "d": ["Catalysis of the reaction: 2 hydroxylamine + 2 NAD+ = 2 H+ + hyponitrous acid + 2 NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937369", "l": "ATAD2 binds ESR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56257", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66225", "l": "asc-C9-CoA + O2 => asc-DeltaC9-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53389", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate => 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9635440", "l": "PapA5 transforms mycocerosyl to PDIM (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69721", "l": "(indol-3-yl)acetyl-AMP + diphosphate => (indol-3-yl)acetate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47610", "l": "3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA => 3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14755", "l": "acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65243", "l": "(11Z)-octadecenoyl-CoA + H2O <=> (11Z)-octadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801762", "l": "REG3A oligomerize to form a pore complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72550", "l": "2-oxoglutarate(in) + taurocholate(out) <=> 2-oxoglutarate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42139", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-500708", "l": "GRIK3 homomer binds glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16674", "l": "3-phosphonopyruvate + H2O => H(+) + phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45991", "l": "3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2 <=> 3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430135", "l": "p-SLP-76 binds ADAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53018", "l": "chloride + glutathione disulfide + H(+) + hydroquinone => chlorohydroquinone + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13519", "l": "ADP + dTDP => ATP + dTMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429992", "l": "PARN deadenylates mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5591086", "l": "SERPINA5 binds activated protein C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112703", "l": "PTPN11 is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20741", "l": "H2O + trans-2,3-epoxysuccinate => (2R,3S)-tartrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76116", "l": "2-oxoglutarate + O2 + thebaine => 6-O-demethylthebaine + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004155", "l": "6,7-dihydropteridine reductase activity", "d": ["Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204798", "l": "Interaction of Tie2 and p85 of PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14722", "l": "UDP-alpha-D-xylose + zeatin => H(+) + O-beta-D-xylosylzeatin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685319", "l": "CX3 complex formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632412", "l": "PTK2 is recruited to methylated ESR1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38118", "l": "(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol <=> 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24468", "l": "H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40544", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696323", "l": "CNRs bind CNR agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18166", "l": "biphenyl + H(+) + NADH + O2 => (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24046", "l": "4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+) => 3,4-dihydroxybenzoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17074", "l": "acetyl-CoA + cortisol => CoA + cortisol 21-acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.25", "l": "\"bile acid CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20920", "l": "2,4-dichlorophenol + H(+) + NADPH + O2 = 3,5-dichlorocatechol + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.20", "l": "\"2,4-dichlorophenol 6-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39478", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA <=> (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2534365", "l": "Slo3 Potassium Transport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11778", "l": "(9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12708", "l": "[protein]-L-isoaspartate + S-adenosyl-L-methionine <=> [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14482", "l": "2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74304", "l": "12alpha-hydroxy-3-oxochola-4-en-24-oate + NAD(+) => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35032", "l": "L-serine(in) => L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047399", "l": "glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + 6-(D-glucose-1-phospho)-D-mannosylglycoprotein = D-mannosylglycoprotein + D-glucose-alpha-1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25745", "l": "(E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-pentahomomethionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46085", "l": "H2O + sn-glycerol 1-phosphate => glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112120", "l": "Oxidative demethylation of 3-meC damaged DNA by ALKBH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088134", "l": "PLK1 phosphorylates FOXM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19765", "l": "glycerol = 3-hydroxypropanal + H2O", "d": []}, {"i": "EC:4.2.1.30", "l": "\"glycerol dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21895", "l": "D-arabinose + NADP(+) <=> D-arabinono-1,4-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112510", "l": "IL6ST is tyrosine phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57140", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14925", "l": "D-mannitol 1-phosphate + NADP(+) = D-mannose 6-phosphate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.224", "l": "\"mannose-6-phosphate 6-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390593", "l": "ATP Hydrolysis By Myosin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18204", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216043", "l": "Collagen type II binds integrin alpha10beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180687", "l": "Conversion of Ran-GDP to Ran-GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19516", "l": "carbamoyl phosphate + L-ornithine <=> H(+) + L-citrulline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74777", "l": "7,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine => kaempferide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "61.235172407545569", "identifiers": [{"i": "GO:0004553", "l": "hydrolase activity, hydrolyzing O-glycosyl compounds", "d": ["Catalysis of the hydrolysis of any O-glycosyl bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25378", "l": "a 2-hydroxy-3-methyl fatty acyl-CoA <=> a 2-methyl-branched fatty aldehyde + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022728", "l": "FKBP5 gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57777", "l": "2-chloro-6-nitrotoluene + NADH + O2 => 4-chloro-3-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4395236", "l": "TP53 binds promoters of MIR34 genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56962", "l": "a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate => a ribonucleoside 5'-triphosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67629", "l": "ATP + dGMP + L-aspartate => (2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656209", "l": "Dissociation of RAS:RAF1 mutant complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265301", "l": "Corticotropin cleavage from POMC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67313", "l": "(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one => myceliothermophin E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203700", "l": "eNOS translocation from Golgi to Caveolae (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71347", "l": "chloride(out) + L-lysine(out) + 2 Na(+)(out) = chloride(in) + L-lysine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56277", "l": "ATP + L-proline => 3'-L-prolyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395801", "l": "Phosphorylation of LAT by p-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167686", "l": "Active PLCG1 hydrolyses PIP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755303", "l": "26S proteasome degrades HIFalpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28428", "l": "keto-D-fructose 6-phosphate => D-allulose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9650165", "l": "ASIC trimers bind H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35943", "l": "brevianamide F + dimethylallyl diphosphate = deoxybrevianamide E + diphosphate", "d": []}, {"i": "EC:2.5.1.109", "l": "\"brevianamide F prenyltransferase (deoxybrevianamide E-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66200", "l": "O2 + pentanoyl-CoA = (2E)-pentenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67294", "l": "(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one => (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71303", "l": "RPE dimers isomerise RU5P to XY5P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13602", "l": "cis-4-hydroxy-L-proline + NAD(+) => 4-oxo-L-proline + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709883", "l": "BIL:ALB scavenges O2.- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65270", "l": "chrodrimanin F + H2O + NADP(+) => 3-hydroxypentacecilide A + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809521", "l": "BPIF binds bacteria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61985", "l": "H(+) + NADH + ubiquinone-10 => NAD(+) + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56239", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50161", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73025", "l": "pregnenolone sulfate(in) => pregnenolone sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63133", "l": "apo-[alkylcobalamin reductase] + glutathione + methylcob(III)alamin => cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-methyl glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73119", "l": "kaempferol + S-adenosyl-L-methionine = H(+) + kaempferol 7-methyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63140", "l": "H2O + N-tetracosanoyl-taurine = taurine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25296", "l": "acetate + 2 H(+) + NADH => acetaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74661", "l": "H(+) + N-acetyl-D-glucosamine 6-phosphate + UDP => N-acetyl-D-glucosamine + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53364", "l": "5,6-dihydrouridine(47) in tRNA + NAD(+) = H(+) + NADH + uridine(47) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55518", "l": "11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755600", "l": "Defective DOLK does not phosphorylate DCHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940134", "l": "FOLR2 binds FOLA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44498", "l": "2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22753", "l": "A + H2O + uracil => AH2 + barbiturate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63128", "l": "H2O + N-docosanoyl-ethanolamine = docosanoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186819", "l": "SH2 domain of Src binds to the active receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35956", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B => 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24421", "l": "H2O + N-terminal N-formyl-L-methionyl-[peptide] => formate + N-terminal L-methionyl-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36813", "l": "CoA + GDP-N-acetyl-alpha-D-perosamine + H(+) => acetyl-CoA + GDP-alpha-D-perosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948027", "l": "RNASEs bind bacterial phospholipids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21739", "l": "(3S)-3,6-diaminohexanoate <=> (3S,5S)-3,5-diaminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006585", "l": "PTPN4 gene expression is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24865", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 = 4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24618", "l": "estrone + H(+) + NADPH => 17beta-estradiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42090", "l": "all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687465", "l": "MRN complex binds RBBP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43264", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357472", "l": "PAK1-3 autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20701", "l": "ATP + lipid A disaccharide (E. coli) => ADP + H(+) + lipid IVA (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11570", "l": "5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32163", "l": "ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine = AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": []}, {"i": "EC:6.3.2.38", "l": "\"N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67383", "l": "H2O + L-alanyl-L-cysteine <=> L-alanine + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222485", "l": "TrxB reactivates TrxA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76466", "l": "CYP4A11 12-hydroxylates DDCX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202466", "l": "Interaction of Bcl10 to CARMA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32743", "l": "L-homocysteine + O-acetyl-L-serine = acetate + H(+) + L,L-cystathionine", "d": []}, {"i": "EC:2.5.1.134", "l": "\"cystathionine beta-synthase (O-acetyl-L-serine)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41942", "l": "[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate => [amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62125", "l": "a 2'-deoxyribonucleoside 5'-phosphate + GTP => a 2'-deoxyribonucleoside 5'-diphosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74345", "l": "O-hexanoyl-(R)-carnitine(out) => O-hexanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928615", "l": "EFNBs bind SFKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27642", "l": "adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9794008", "l": "LUBAC binds CFLAR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784959", "l": "BPHL hydrolyses VACV to ACV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50800", "l": "glutathione + prostaglandin A2 = prostaglandin A2-S-(S)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33025", "l": "CO2 + D-ribulose 5-phosphate + NADH => 6-phospho-D-gluconate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166817", "l": "Cleavage of C3 by C3 convertases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964284", "l": "BTK in active Gq-BTK complex is activated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20156", "l": "ATP + L-arabinose <=> ADP + beta-L-arabinose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983421", "l": "Journey of cargo through Golgi complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52879", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate <=> 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71891", "l": "dGMP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-dGMP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9681294", "l": "IL6R binds IL6R inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67224", "l": "(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31538", "l": "2-oxoglutarate + L-arginine + O2 <=> (S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052790", "l": "chitooligosaccharide deacetylase activity", "d": ["Catalysis of the reaction: chitooligosaccharide with N-acetylglucosamine at nonreducing terminal + H2O = chitooligosaccharide with glucosamine at nonreducing terminal + acetate. This reaction is the deacetylation of a chitooligosaccharide at the nonreducing N-acetylglucosamine residue; chitooligosaccharide are composed of (1->4)-linked D-glucosamine (GlcN) and N-acetyl-D-glucosamine (GlcNAc) in varying proportions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-434650", "l": "MATEs mediate extrusion of xenobiotics (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32198", "l": "abieta-7,13-dien-18,18-diol <=> abieta-7,13-dien-18-al + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034880", "l": "citrazinate dehydrogenase activity", "d": ["Catalysis of the reaction: citrazinate + H2O = 2,3,6-trihydroxyisonicotinate + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035227", "l": "TXN2 binds CysS248-MPST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22377", "l": "uridine(38/39/40) in tRNA => pseudouridine(38/39/40) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28580", "l": "Co(2+)(out) => Co(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28998", "l": "H(+)(out) + L-threonine(in) <=> H(+)(in) + L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20396", "l": "holo-[citrate lyase ACP] + S-acetylphosphopantotheine <=> (R)-4'-phosphopantetheine + acetyl-[citrate lyase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043765", "l": "T/G mismatch-specific endonuclease activity", "d": ["Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016041", "l": "glutamate synthase (ferredoxin) activity", "d": ["Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + 2 oxidized ferredoxin + H2O = NH3 + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814555", "l": "Integrator complex processes the 3' end of snRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9620456", "l": "sGC stimulators bind sGC:NO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17488", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67618", "l": "8-oxo-GMP + diphosphate + H(+) => 8-oxo-GTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37434", "l": "12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16228", "l": "1,8-diazacyclotetradecane-2,9-dione + H2O <=> N-(6-aminohexanoyl)-6-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22483", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) <=> 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21555", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62253", "l": "2 hydrogencarbonate(out) + Zn(2+)(out) => 2 hydrogencarbonate(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43979", "l": "H(+) + hexadecanoate + NADPH + O2 <=> 14-hydroxyhexadecanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956639", "l": "RUNX1 binds YAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801209", "l": "TP53 binds the TRIAP1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0061605", "l": "molybdopterin-synthase adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674562", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59235", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> diphosphate + hydropyrenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15664", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside <=> an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42901", "l": "guanosine(745) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449829", "l": "IL11 binds IL11RA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0120250", "l": "fatty acid omega-hydroxylase activity", "d": ["Catalysis of the reaction: an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."]}, {"i": "RHEA:39023", "l": "an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36021", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629918", "l": "NEIL1 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2089971", "l": "Secretion of collagens (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.744066580938323", "identifiers": [{"i": "GO:0061630", "l": "ubiquitin protein ligase activity", "d": ["Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660706", "l": "Defective SLC6A3 does not cotransport DA, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68243", "l": "L-methionine(in) + Na(+)(in) <=> L-methionine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13083", "l": "biotin + NH4(+) => biotin amide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449058", "l": "Interleukin-1 family are secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785213", "l": "LIPC dimer binds heparin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019178", "l": "NADP phosphatase activity", "d": ["Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031693", "l": "alpha-1D adrenergic receptor binding", "d": ["Binding to an alpha-1D adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662620", "l": "MT3 binds cadmium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58040", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139895", "l": "tBID activates BAK protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10763", "l": "citrate <=> acetate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018798", "l": "gallate decarboxylase activity", "d": ["Catalysis of the reaction: gallate + H+ = CO2 + pyrogallol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2172433", "l": "Collagen type XIX degradation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731931", "l": "EDNRA binds selective ERAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811427", "l": "COPI vesicle uncoating at the ER (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24945", "l": "(4S)-4-hydroxy-L-glutamate + H(+) + NADPH => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22882", "l": "L-glutamate + prephenate => 2-oxoglutarate + L-arogenate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018559", "l": "1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 1,1-dichloro-2-(dihydroxy-4'-chorophenyl)-2-(4-chlorophenyl)ethene + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53221", "l": "16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734730", "l": "ORC1 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050472", "l": "zeatin reductase activity", "d": ["Catalysis of the reaction: dihydrozeatin + NADP+ = H+ + NADPH + zeatin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52856", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine", "d": []}, {"i": "EC:1.5.8.4", "l": "\"dimethylglycine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76108", "l": "(11R)-methyl carlactonoate + 2-oxoglutarate + O2 => (11R)-hydroxymethyl carlactonoate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62056", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31016", "l": "H(+) + indole-3-carboxylate => CO2 + indole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663252", "l": "NR1D1 (REV-ERBA) binds heme, the ELOVL3 gene, and recruits corepressors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44674", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428510", "l": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-984689", "l": "Kinesin-7 is a dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57047", "l": "D-apionate + NAD(+) <=> 3-oxoisoapionate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18705", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654515", "l": "KAL1 binds HS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34680", "l": "ATP + methylphosphonate => adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49390", "l": "H(+) + UDP + validamycin A => UDP-alpha-D-glucose + validoxylamine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2993802", "l": "HLCS biotinylates PC:Mn2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2299620", "l": "Collagen XI cross-links with collagen II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36196", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43168", "l": "adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)", "d": []}, {"i": "EC:3.5.4.33", "l": "\"tRNA(adenine(34)) deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68808", "l": "6-O-alpha-D-glucopyranosyl-D-fructose + H2O = alpha-D-glucose + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16978", "l": "acetoacetate + coenzyme M + NADP(+) => 2-oxopropyl-coenzyme M + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10822", "l": "D-erythro-isocitrate => D-threo-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626220", "l": "C2CD3 binds the mother centriole (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55490", "l": "ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43499", "l": "L-gulonate + NAD(+) <=> H(+) + keto-D-fructuronate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0016872", "l": "intramolecular lyase activity", "d": ["The catalysis of certain rearrangements of a molecule to break or form a ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664867", "l": "NBR1 binds MAP1LC3B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48802", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+) => a neolactoside nLc4Cer + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32597", "l": "6-hydroxy-3,7-dimethyloctanoate + H(+) => 7-isopropyl-4-methyloxepan-2-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74716", "l": "Insulin binds the insulin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55262", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67379", "l": "glycyl-L-histidine + H2O <=> glycine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2559439", "l": "CD14:LPS binds CR3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22831", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + H2O <=> 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199169", "l": "MHC Class I interacts with CD160 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374662", "l": "Translocation of Ezrin to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70770", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19471", "l": "H(+) + NAD(+) + 2 nitrate => NADH + 2 nitric oxide + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69399", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA <=> an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53106", "l": "4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine => 4-hydroxyestrone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61665", "l": "(2E,6E,10E)-geranylgeraniol + ATP => (2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944265", "l": "Association of procollagen type IV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19922", "l": "D-ribitol 5-phosphate + NADP(+) => D-ribulose 5-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46011", "l": "CoA + NAD(+) + pentanal <=> H(+) + NADH + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0030519", "l": "snoRNP binding", "d": ["Binding to a small nucleolar ribonucleoprotein particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72248", "l": "(R)-noradrenaline + S-adenosyl-L-methionine => (R)-normetanephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983078", "l": "p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53872", "l": "CTP + D-ribose 5-phosphate + H(+) = CDP-D-ribose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416929", "l": "PTGFR binds PGF2a (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75089", "l": "32-oxo-24,25-dihydrolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 32-hydroxy-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46575", "l": "2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62609", "l": "glutathione + H(+) + hydrogen sulfide + ubiquinone-10 => S-sulfanylglutathione + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66317", "l": "an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O => alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20314", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP => 1D-myo-inositol hexakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38660", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64762", "l": "ethanethiol + NH4(+) + pyruvate => H2O + S-ethyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018715", "l": "9-phenanthrol UDP-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: 9-phenanthrol + UDP-glucuronate = 9-phenanthryl-beta-D-glucuronide + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204824", "l": "Interaction of Tie2 and Ang4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63724", "l": "candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D-glucuronoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50657", "l": "3-(2-methylsulfanyl)ethylmalate => 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26456", "l": "acryloyl-CoA + H(+) + NADPH => NADP(+) + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59549", "l": "N,N',N''-triacetylchitotriose + O2 => H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56729", "l": "4-hydroxy-all-trans-beta-carotene + AH2 + O2 => 4,4-dihydroxy-all-trans-beta-carotene + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25162", "l": "L-glutamate + L-glutamate 5-semialdehyde => 2-oxoglutarate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592278", "l": "Autocatalytic activation of proMMP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043714", "l": "(R)-citramalate synthase activity", "d": ["Catalysis of the reaction: pyruvate + acetyl-CoA + H2O = (R)-citramalate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3785768", "l": "MRN complex binds DNA double strand breaks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29918", "l": "L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) + UDP-alpha-D-glucose <=> alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33183", "l": "citrate(in) = citrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60850", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein] => a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047940", "l": "glucuronokinase activity", "d": ["Catalysis of the reaction: D-glucuronate + ATP = 1-phospho-alpha-D-glucuronate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.48", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52612", "l": "3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.99.41", "l": "\"3-(methylsulfanyl)propanoyl-CoA 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14975", "l": "D-aspartate => L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40507", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655852", "l": "Expression of Lathosterol Oxidase (SC5D, SC5DL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68678", "l": "adenosine 3',5'-bisphosphate + estrone 3-O-(3-sulfo-beta-D-glucuronate) + H(+) => 3'-phosphoadenylyl sulfate + estrone 3-O-(beta-D-glucuronate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61206", "l": "H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein] => L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641147", "l": "DACT1 binds DVL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022141", "l": "Prolysyl oxidase activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69883", "l": "L-ascorbate(out) + 2 Na(+)(out) = L-ascorbate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25804", "l": "H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5591052", "l": "PROCR binds Protein C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46357", "l": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] => 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865276", "l": "PDGF-AB clevage by Furin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63674", "l": "H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) => (8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425861", "l": "Activation of Protein Kinase C novel isoforms (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662466", "l": "XYLB phosphorylates D-xylulose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798748", "l": "Exocytosis of secretory granule lumen proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75464", "l": "choline(out) + n H(+)(in) => choline(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51657", "l": "keto-D-tagaturonate => keto-D-fructuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64521", "l": "acetyl-CoA + AH2 + 3 H(+) + 3 malonyl-CoA => A + 3 CO2 + 4 CoA + H2O + orsellinaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-994148", "l": "LRRC16A binds F-actin capping protein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20719", "l": "H(+) + H2O + S-adenosyl-L-homocysteine <=> NH4(+) + S-inosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848338", "l": "PNPLA4 hydrolyzes TAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390597", "l": "Release Of ADP From Myosin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700171", "l": "Active ALK phosphorylates PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102720", "l": "acetyl-coenzyme A:acetyl alcohol acetyltransferase activity", "d": ["Catalysis of the reaction: benzyl alcohol + acetyl-CoA = benzyl acetate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42487", "l": "D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-sorbitol 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60733", "l": "H2O + NADP(+) + perillyl aldehyde => 2 H(+) + NADPH + perillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61058", "l": "H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656070", "l": "FGFBPs bind FGFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65393", "l": "4 H(+) + L-pipecolate + malonyl-CoA + 2 NADPH => (8aS)-octahydroindolizin-1-one + CO2 + CoA + 2 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46342", "l": "ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate => ATP + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51216", "l": "3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25036", "l": "all-trans-retinol + NADP(+) <=> all-trans-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44553", "l": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O => H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627089", "l": "CASP9 is phosphorylated at T412 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68570", "l": "(3S)-1,2-diazinane-3-carboxylate + H(+) + H2O => N(5)-hydroxy-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197963", "l": "DHFR2 reduces FOLA to DHF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669013", "l": "EDA-3 binds EDA2R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42975", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a cardiolipin + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061752", "l": "telomeric repeat-containing RNA binding", "d": ["Binding to long non-coding RNA molecules transcribed from subtelomeric regions in most eukaryotes. Telomeric repeat-containing RNA (TERRA) molecules consist of subtelomeric-derived sequences and G-rich telomeric repeats."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26008", "l": "beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP => di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44304", "l": "a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA = a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73579", "l": "(E,E)-piperoyl-AMP + CoA = (E,E)-piperoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18373", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.154", "l": "\"phosphatidylinositol-4-phosphate 3-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25860", "l": "GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)", "d": []}, {"i": "EC:3.5.4.39", "l": "\"GTP cyclohydrolase IV\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37127", "l": "2-oxoglutarate + dioxidophosphate + H2O2 = CO2 + H(+) + phosphonate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252001", "l": "ATP1B4 binds SNW1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34065", "l": "2'-deamino-2'-hydroxyparomamine + H(+) + UDP => 2-deoxystreptamine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57822", "l": "[phosphate](n+1) + AMP => [phosphate](n) + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38922", "l": "H2O + sphing-4-enine-phosphocholine <=> choline + H(+) + sphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24070", "l": "H2O + hexano-6-lactone + NADP(+) => cyclohexanone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186786", "l": "Autophosphorylation of PDGF beta receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4647594", "l": "SAHF formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75238", "l": "TRAIL binds TRAIL receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0052905", "l": "tRNA (guanine(9)-N(1))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanine(9) in tRNA = N(1)-methylguanine(9) in tRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6805061", "l": "CK2 binds FACT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13767", "l": "bromide + chloride + formaldehyde + 2 H(+) => bromochloromethane + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26395", "l": "2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial => all-trans-zeaxanthin + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211301", "l": "PDX1-dependent synthesis of IAPP protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63749", "l": "UDP-alpha-D-glucuronate + zolasartan => UDP + zolarsartan-2-N-beta-D-glucuronide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53511", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione <=> (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624120", "l": "CEBPA binds CDK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24329", "l": "7,8-dihydrofolate + ATP + formate => 10-formyldihydrofolate + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51537", "l": "L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2395517", "l": "NADPH transfers electrons to FDXR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29810", "l": "ATP + H2O + L-leucine(out) <=> ADP + H(+) + L-leucine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35742", "l": "cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] <=> 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165195", "l": "GTP loading by Rheb (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322431", "l": "XIAP binds TLE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42686", "l": "L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide => gamma-L-glutamyl-hercynylcysteine S-oxide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56648", "l": "3-oxochol-4-en-24-oyl-CoA + NAD(+) = 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65165", "l": "benzoyl-CoA + hexan-3-ol => CoA + hexan-3-yl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391942", "l": "IP receptor can bind prostacyclin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018466", "l": "limonene-1,2-diol dehydrogenase activity", "d": ["Catalysis of the reaction: (1S,2S,4R)-limonene-1,2-diol + DCPIP+ = DCPIPH + H+ + (1S,4R)-1-hydroxy-2-oxolimonene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189062", "l": "lactose + H2O => D-glucose + D-galactose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390329", "l": "Dephosphorylation of AKT by PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27636", "l": "2,5-didehydro-D-gluconate + H(+) + NADPH => 5-dehydro-D-gluconate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002466", "l": "Formation of allysine by LOX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41669", "l": "dihydrochelirubine + NADP(+) => chelirubine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624120", "l": "CEBPA binds CDK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12382", "l": "L-alanine + L-aspartate 4-semialdehyde => L-2,4-diaminobutanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69373", "l": "2-hydroxyhexanoate + O2 => 2-oxohexanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191303", "l": "FDPS dimer transfers IPPP to GPP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5603467", "l": "Activated protein C is released from PROCR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34843", "l": "7,8-dihydromonapterin 3'-triphosphate + 3 H2O = 7,8-dihydromonapterin + 2 H(+) + 3 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730842", "l": "PI3K associates with phosphorylated GAB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64903", "l": "H2O + UTP <=> H(+) + phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0005313", "l": "L-glutamate transmembrane transporter activity", "d": ["Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45422", "l": "a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine => H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034865", "l": "2,4,4-trimethylpentanoate-CoA ligase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethylpentanoate + CoASH = 2,4,4-trimethylpentanoyl-CoA + OH-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68815", "l": "(2Z,6E)-farnesyl diphosphate <=> beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21456", "l": "(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.68", "l": "\"(S)-canadine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27969", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O <=> 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9726580", "l": "PGR binds PGR agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202325", "l": "Recruitment of Gads to LAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66271", "l": "CoA + nonanoyl-AMP <=> AMP + H(+) + nonanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23395", "l": "(n-1) H2O + RNA(n) <=> n a ribonucleoside 5'-phosphate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209210", "l": "STAT92E is phosphorylated by phosphorylated HOP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28444", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + holo-[ACP] => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + dodecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029268", "l": "Phosphorylation and activation of PLCG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25529", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48798", "l": "19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450325", "l": "c-FOS activation by phospho ERK1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39398", "l": "3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28666", "l": "H2O + melibiose <=> D-galactose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35108", "l": "3-nitrotyramine + H2O + O2 => 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70166", "l": "H(+)(in) + methotrexate(in) <=> H(+)(out) + methotrexate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655837", "l": "Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21285", "l": "all-trans-retinol + NAD(+) => all-trans-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.3", "l": "\"oligonucleotidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58580", "l": "dihydroprecondylocarpine acetate = acetate + catharanthine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65341", "l": "acetyl-CoA + L-threonyl-[protein] => CoA + O-acetyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6794347", "l": "Homer1,2,3 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11949", "l": "4-hydroxybenzoyl-CoA + H2O => 4-hydroxybenzoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67603", "l": "H2O + O(6)-methyl-dGTP <=> diphosphate + H(+) + O(6)-methyl-dGMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31242", "l": "4 H(+) + uroporphyrinogen I <=> 4 CO2 + coproporphyrinogen I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25766", "l": "(2R,3S)-3-methylmalate + NAD(+) <=> 3-carboxy-2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44404", "l": "3-demethylubiquinol-7 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21009", "l": "diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) => diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389963", "l": "alpha-tubulin:GTP:Cofactor B  +Cofactor E ->  alpha-tubulin:GTP: Cofactor E +Cofactor B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9704248", "l": "CHRM4 binds CHRM4 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019139", "l": "cytokinin dehydrogenase activity", "d": ["Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801641", "l": "TP53 binds the PLK2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67868", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] = 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13326", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine => 3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034940", "l": "5-oxo-4,5-dihydropyrrole-2-carboxylate amidase activity", "d": ["Catalysis of the reaction: 5-oxo-4,5-dihydropyrrole-2-carboxylate + 2 H2O = 2-oxoglutarate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141159", "l": "TNF-mediated dimerization of procaspase-8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165195", "l": "GTP loading by Rheb (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64416", "l": "D-xylofuranose + NADP(+) = D-xylono-1,4-lactone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.424", "l": "\"D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,4-lactone-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29380", "l": "dGMP + H2O => 2'-deoxyguanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71827", "l": "arsenate(in) + H(+)(in) = arsenate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10104", "l": "2-oxoglutarate + gibberellin A20 + O2 = CO2 + gibberellin A1 + succinate", "d": []}, {"i": "EC:1.14.11.15", "l": "\"gibberellin 3beta-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71171", "l": "H(+)(in) + L-cysteine(out) + Na(+)(out) = H(+)(out) + L-cysteine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71080", "l": "cordypyrone A + O2 + reduced [NADPH--hemoprotein reductase] => cordypyrone B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20292", "l": "acetyl-CoA + H2O <=> acetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382061", "l": "Extracellular processing of novel PDGFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69805", "l": "benzoyl-AMP + diphosphate => ATP + benzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018651", "l": "toluene-4-sulfonate monooxygenase activity", "d": ["Catalysis of the reaction: toluene-4-sulfonate + 1/2 O2 + H+ = HSO3(-) + 4-hydroxytoluene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39665", "l": "a quinone + reduced coenzyme F420-(gamma-L-Glu)(n) => a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27422", "l": "(2E,6E)-farnesyl diphosphate => (3E,6E)-alpha-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75473", "l": "thiamine diphosphate(in) => thiamine diphosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508451", "l": "PTK2B is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180006", "l": "RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 2) + H2O = RNA polymerase II large subunit + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604360", "l": "Initial activation of proMMP2 by MMP14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783681", "l": "LIF binds LIFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31867", "l": "(S)-2,3-epoxysqualene = baccharis oxide", "d": []}, {"i": "EC:5.4.99.51", "l": "\"baccharis oxide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58160", "l": "ent-copalyl diphosphate = diphosphate + dolabradiene", "d": []}, {"i": "EC:4.2.3.196", "l": "\"dolabradiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63190", "l": "A + H2O + norbelladine => 3,4-dihydroxybenzaldehyde + AH2 + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50372", "l": "an N-acylsphingoid base 1-phosphate(in) = an N-acylsphingoid base 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27931", "l": "(R)-4-phosphopantoate + ATP + beta-alanine => (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29504", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + patchoulol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32105", "l": "2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + trans-resveratrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.-", "l": "\"Phosphorus-oxygen lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39049", "l": "2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase] => 26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426566", "l": "Interaction of DAP12 and CLM7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781905", "l": "ZRANB1 binds APC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47447", "l": "3-oxo-(7Z-hexadecenoyl)-CoA + CoA <=> (5Z)-tetradecenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390886", "l": "HRH4 binds Hist (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23476", "l": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O", "d": []}, {"i": "EC:4.1.1.48", "l": "\"indole-3-glycerol-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31147", "l": "3,4-dihydroxyphenylethyleneglycol + NAD(+) = 3,4-dihydroxymandelaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.11", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033863", "l": "ribose 1,5-bisphosphate phosphokinase activity", "d": ["Catalysis of the reaction: D-ribose 1,5-diphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858252", "l": "HDLBP binds HDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944261", "l": "Association of procollagen type XIII (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36411", "l": "7-dehydrocholesterol + hnu = calciol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0140848", "l": "amino acid:monoatomic cation antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + monoatomic cation(in) = solute(in) + monoatomic cation(out). Monoatomic cations include H+, Mg2+, Ca2+, etc."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61526", "l": "(15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34467", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + valerena-4,7(11)-diene", "d": []}, {"i": "EC:4.2.3.139", "l": "\"valerena-4,7(11)-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61291", "l": "5-deoxy-D-ribose + ATP <=> 5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170674", "l": "Dissociation of the Gi alpha:G olf complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25817", "l": "H2O + norspermine + O2 => 3-aminopropanal + H2O2 + norspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48698", "l": "H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol => 1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9677051", "l": "Formation of the PCAF-ATAC complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37849", "l": "daunorubicin + 2 H2O + NADP(+) => 13-dihydrodaunorubicin + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74716", "l": "Insulin binds the insulin receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033801", "l": "vitexin 2''-O-rhamnoside 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2''-O-beta-L-rhamnoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74417", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755545", "l": "Defective DHDDS does not elongate E,E-FPP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21180", "l": "1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = D-glucose + indole-3-acetyl-1D-myo-inositol", "d": []}, {"i": "EC:2.3.1.72", "l": "\"indoleacetylglucose--inositol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61048", "l": "lochnericine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44571", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) <=> 2-all-trans-hexaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31751", "l": "chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004694", "l": "eukaryotic translation initiation factor 2alpha kinase activity", "d": ["Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679205", "l": "ULK1 phosphorylates Beclin-1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25118", "l": "H2O + L-lysine + NAD(+) => (S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25470", "l": "beta-himachalene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83677", "l": "C4 deamination of cytidine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43378", "l": "5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine => 5'-deoxyinosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16029", "l": "3-guanidinopropanoate + H2O = beta-alanine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67917", "l": "adenosine 5'-phosphoramidate + H2O => AMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036432", "l": "all-trans undecaprenol kinase activity", "d": ["Catalysis of the reaction: ATP + undecaprenol + all-trans-undecaprenyl phosphate + ADP + H+."]}, {"i": "RHEA:23752", "l": "all-trans-undecaprenol + ATP = ADP + all-trans-undecaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75115", "l": "all-trans-13,14-dihydroretinol + NAD(+) = all-trans-13,14-dihydroretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0015189", "l": "L-lysine transmembrane transporter activity", "d": ["Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047377", "l": "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity", "d": ["Catalysis of the reaction: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655483", "l": "USP1 autocleavage (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68949", "l": "esculetin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42245", "l": "H(+) + malonyl-[ACP] + propanoyl-CoA => 3-oxopentanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.651716354923636", "identifiers": [{"i": "GO:0016701", "l": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor."]}, {"i": "EC:1.13.-.-", "l": "\"Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1500781", "l": "Fgd1 reactivates F420 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69468", "l": "2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose = L-glutamate + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": []}, {"i": "EC:2.6.1.122", "l": "\"UDP-N-acetyl-3-dehydro-alpha-D-glucosamine 3-aminotranferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37491", "l": "4-coumaroyl-CoA + S-adenosyl-L-methionine = CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.3.1.229", "l": "\"4-coumaroyl-homoserine lactone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2509831", "l": "ITPA hydrolyses XTP to XMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16498", "l": "adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217204", "l": "Activation and association of ATM kinase at the DNA damage sites (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050476", "l": "acetylenedicarboxylate decarboxylase activity", "d": ["Catalysis of the reaction: H2O + acetylenedicarboxylate = CO2 + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004489", "l": "methylenetetrahydrofolate reductase (NAD(P)H) activity", "d": ["Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156910", "l": "Formation of eEF1B complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18824", "l": "acetyl-CoA + choline <=> acetylcholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798748", "l": "Exocytosis of secretory granule lumen proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015504", "l": "cytosine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cytosine(out) + H+(out) = cytosine(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33030", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene <=> 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9619376", "l": "CAMK1 binds calmodulin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71457", "l": "L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartate => goralatide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48814", "l": "(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351876", "l": "Caspase-mediated cleavage of occludin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202534", "l": "Ubiquitination of NEMO by TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55684", "l": "chorismate + NH4(+) = 4-amino-4-deoxychorismate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6795667", "l": "MDM2 translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62386", "l": "(2R)-2,3-bisphosphoglycerate + 2 H(+) => cyclic (2R)-2,3-bisphosphoglycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24271", "l": "2,6-dioxo-6-phenylhexanoate + NADP(+) <=> 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32170", "l": "ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> aerobactin + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003998", "l": "acylphosphatase activity", "d": ["Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008713", "l": "ADP-heptose-lipopolysaccharide heptosyltransferase activity", "d": ["Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080101", "l": "phosphatidyl-N-dimethylethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19020", "l": "(6S)-NADHX + ATP <=> ADP + H(+) + NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.4", "l": "\"ABC-type teichoic-acid transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32169", "l": "aerobactin + AMP + diphosphate + H(+) => ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428909", "l": "Activated TP receptor binds G-protein  G13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56778", "l": "(+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35733", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + CoA => sn-glycerol 3-phosphate + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956684", "l": "ITCH polyubiquitinates TP73 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0000033", "l": "alpha-1,3-mannosyltransferase activity", "d": ["Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19012", "l": "a 3-acylpyruvate + H2O <=> a carboxylate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53386", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH => 5,10-methylenetetrahydromethanopterin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61368", "l": "4-methylumbelliferone sulfate(in) + ATP + H2O = 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20963", "l": "1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68565", "l": "6-methoxycoumarin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016428", "l": "tRNA (cytosine-5-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33873", "l": "glyoxylate + NH4(+) + urea => (S)-2-ureidoglycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65932", "l": "3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine = 3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-741411", "l": "CYLD deubiquitinates NEMO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37559", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54997", "l": "3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034827", "l": "1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + O2 = 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34541", "l": "methanetellurite + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + tellurite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22500", "l": "(E)-feruloyl-CoA + H(+) + malonyl-CoA = (E)-feruloylacetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11076", "l": "anthranilate + 3 H(+) + NADH + O2 = catechol + CO2 + NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40583", "l": "H2O + hexanedioyl-CoA = CoA + H(+) + hexanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928591", "l": "EPH:EFN tetramers oligomerise (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15755", "l": "GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate => GTP + IMP + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671702", "l": "AP1G2 binds HGS and CHMP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854052", "l": "Formation of the SCF-FBXL7 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389845", "l": "TUFM:GTP binds aminoacyl-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734687", "l": "ORC6 is phosphorylated on T195 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707505", "l": "Hemes bind to CLEC1B dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008908", "l": "isochorismatase activity", "d": ["Catalysis of the reaction: H2O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990698", "l": "palmitoleoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756671", "l": "EOMES and TBXT bind the NANOG gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51528", "l": "H(+) + vanillate = CO2 + guaiacol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44115", "l": "hexadecanoyl-CoA + nonan-1-ol <=> CoA + nonyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11014", "l": "L-tryptophan + NH4(+) => H2O + L-tryptophanamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34457", "l": "9-cis-beta-carotene => all-trans-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20983", "l": "2 bilirubin IXalpha + O2 <=> 2 biliverdin IXalpha + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982645", "l": "GRKs bind ADRB2:Catecholamine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692376", "l": "BCL2 binds BCL2 antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917839", "l": "apo-Transferrin dissociates from the receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357445", "l": "PAK1-3 dimer disassociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13352", "l": "jasmonate + S-adenosyl-L-methionine <=> methyl (-)-jasmonate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54375", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-(2S,3R,9R)-pristinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42637", "l": "AH2 + L-cysteine + Mo-molybdopterin => A + H2O + L-alanine + thio-Mo-molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14261", "l": "(E)-sinapoyl-CoA + D-glucono-1,5-lactone = 6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA", "d": []}, {"i": "EC:2.3.1.132", "l": "\"glucarolactone O-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39240", "l": "(2E)-triacontenoyl-CoA + H(+) + NADPH => NADP(+) + triacontanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36591", "l": "(S)-2-chloropropanoate + NADP(+) = 2-chloroacrylate + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.103", "l": "\"2-haloacrylate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198669", "l": "p38MAPK phosphorylates MSK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033142", "l": "nuclear progesterone receptor binding", "d": ["Binding to a nuclear progesterone receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004143", "l": "ATP-dependent diacylglycerol kinase activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21740", "l": "2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate", "d": []}, {"i": "EC:2.8.1.2", "l": "\"3-mercaptopyruvate sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52938", "l": "(3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP] => 3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396029", "l": "Latent TGF-beta-3 binds integrins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49226", "l": "dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin] => dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35278", "l": "3-hydroxyoctadecanoyl-CoA + NAD(+) <=> 3-oxooctadecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44623", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674558", "l": "p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008779", "l": "acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24054", "l": "a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein] => a ubiquinone + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73155", "l": "adenosine 3',5'-bisphosphate(out) + FMN(in) = adenosine 3',5'-bisphosphate(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11470", "l": "3-methyl-2-oxobutanoate + L-isoleucine => (S)-3-methyl-2-oxopentanoate + L-valine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.191", "l": "\"UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.10", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102938", "l": "orcinol O-methyltransferase activity", "d": ["Catalysis of the reaction: orcinol + S-adenosyl-L-methionine = H+ + 3-methoxy-5-hydroxytoluene + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70945", "l": "L-isoleucine(out) => L-isoleucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33784", "l": "1(F)-beta-D-fructosylsucrose + sucrose => 1,6-kestotetraose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37168", "l": "(2E,6E)-farnesol + NAD(+) => (2E,6E)-farnesal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16631", "l": "acetyl-CoA + glyoxylate => (S)-malyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.110", "l": "\"aldos-2-ulose dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671737", "l": "p-T774-PKN1 binds CDC25C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72087", "l": "2 Na(+)(out) + taurodeoxycholate(out) = 2 Na(+)(in) + taurodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63037", "l": "H2O + octadecanamide => NH4(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190519", "l": "Internalization of gap junction plaques (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25788", "l": "4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde", "d": []}, {"i": "EC:4.1.2.52", "l": "\"4-hydroxy-2-oxoheptanedioate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70665", "l": "4-hydroxy-L-proline(out) + H(+)(out) => 4-hydroxy-L-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374896", "l": "Uptake of Noradrenaline (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46290", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46881", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15725", "l": "1,5-anhydro-D-fructose = ascopyrone M + H2O", "d": []}, {"i": "EC:4.2.1.111", "l": "\"1,5-anhydro-D-fructose dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.9.-.-", "l": "\"Transferring selenium-containing groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22725", "l": "a sterol + UDP-alpha-D-glucose => a sterol 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54295", "l": "ATP + L-threonyl-[protein] <=> 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296127", "l": "Activation of voltage gated Potassium channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21453", "l": "a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 => a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0016882", "l": "cyclo-ligase activity", "d": ["Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}, {"i": "EC:6.3.3.-", "l": "\"Cyclo-ligases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814695", "l": "PERP binds desmosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43273", "l": "ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GD2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76456", "l": "O-atom dealkylation of dextromethorphan (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694433", "l": "MIA2 binds PREB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34149", "l": "2-deoxy-scyllo-inosamine + 2-oxoglutaramate => 2-deoxy-L-scyllo-inosose + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58561", "l": "15alpha-stemmadenine intermediate II + NADP(+) => 15alpha-stemmadenine intermediate I + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784598", "l": "NPPA(124-151) binds NPR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50564", "l": "acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20431", "l": "acacetin + H(+) + S-adenosyl-L-homocysteine => apigenin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24133", "l": "UDP-alpha-D-galactose => UDP-alpha-D-galactofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57708", "l": "(E)-coniferaldehyde + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-4-trans-coniferyl aldehyde + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008703", "l": "5-amino-6-(5-phosphoribosylamino)uracil reductase activity", "d": ["Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202703", "l": "CD47 binds SIRP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29346", "l": "L-aspartate(in) + succinate(out) <=> L-aspartate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45060", "l": "H2O + N-(9Z-octadecenoyl) ethanolamine = (9Z)-octadecenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65977", "l": "7-dehydrocholesterol + hnu => previtamin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001003", "l": "RNA polymerase III type 2 promoter sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59836", "l": "H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] = 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169307", "l": "Monoubiquitination of N-myristoyl GAG (P12493) protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.52", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43067", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate <=> holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9703895", "l": "CASR binds CASR agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14597", "l": "a CDP-1,2-diacyl-sn-glycerol + choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.24", "l": "\"phosphatidylcholine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433506", "l": "Phosphorylation of APS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220976", "l": "NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36210", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64866", "l": "CO2 + IDP + phosphoenolpyruvate => ITP + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36067", "l": "Co-precorrin-6B + S-adenosyl-L-methionine = Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.196", "l": "\"cobalt-precorrin-6B (C(15))-methyltransferase [decarboxylating]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16630", "l": "(S)-malyl-CoA => acetyl-CoA + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624925", "l": "miR-33 binds to the 3'UTR of the ABCA1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694428", "l": "LMAN family proteins bind glycosylated cargo (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9725206", "l": "IgE binds FCERI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015454", "l": "light-driven active monoatomic ion transmembrane transporter activity", "d": ["Active transport of an ion across a membrane, driven by light."]}, {"i": "TCDB:3.E", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050540", "l": "2-aminomuconate deaminase activity", "d": ["Catalysis of the reaction: 2-aminomuconate + H2O + H+ = (Z)-5-oxohex-2-enedioate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61401", "l": "ATP + N(6)-(D-ribulosyl)-L-lysine => ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40602", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38053", "l": "1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0031078", "l": "histone H3K14 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49863", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46850", "l": "5alpha-cholest-8-en-3-one + CO2 + NADPH => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71355", "l": "5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out) = 5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66014", "l": "[collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O => (5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71192", "l": "an L-alpha-amino acid(in) + L-kynurenine(out) => an L-alpha-amino acid(out) + L-kynurenine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58674", "l": "aldehydo-D-glucuronate => D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987007", "l": "p-STAT1 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.245", "l": "\"alpha,alpha-trehalose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18309", "l": "an N-acyl-D-amino acid + H2O = a carboxylate + a D-alpha-amino acid", "d": []}, {"i": "EC:3.5.1.81", "l": "\"N-acyl-D-amino-acid deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21469", "l": "dTDP-alpha-D-mycaminose + tylactone => 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9793988", "l": "LUBAC ubiquitinates CFLAR at K351, K353 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247836", "l": "Retromer recycles WLS to the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50500", "l": "acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13067", "l": "ADP + H(+) + phosphate => ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050570", "l": "4-hydroxythreonine-4-phosphate dehydrogenase activity", "d": ["Catalysis of the reaction: 4-(phosphonooxy)-threonine + NAD+ = 2-amino-3-oxo-4-phosphonooxybutyrate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65570", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38719", "l": "(R)-carnitine(out) + ATP + H2O = (R)-carnitine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227753", "l": "Caspase 8 or 10 recruitment to IPS1 complex followed by their dimerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31684", "l": "prosolanapyrone III => (-)-solanapyrone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54981", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose => [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418852", "l": "Caspase cleavage of UNC5B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50261", "l": "11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione => (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49050", "l": "1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin] => 25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685607", "l": "Sialic acid binds SIGLEC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928640", "l": "PAKs phosphorylate MLC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102907", "l": "sesquisabinene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + sesquisabinene."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008762", "l": "UDP-N-acetylmuramate dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938121", "l": "SERPINB13 binds CTSK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.26", "l": "\"prolyl oligopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19327", "l": "H2O + NAD(+) + quinoline-3,4-diol => H(+) + NADH + O2 + quinolin-4-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39102", "l": "3-oxodecanedioyl-CoA + CoA <=> acetyl-CoA + octanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649108", "l": "HTR3A pentamer binds 5HT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874200", "l": "CREB3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18664", "l": "H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) <=> H(+) + L-ornithine + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64956", "l": "dTTP + 2 H2O = dTMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.3", "l": "\"omega-amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41774", "l": "CMP + ganglioside GQ1b (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5671702", "l": "AP1G2 binds HGS and CHMP2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169406", "l": "ISGylation of host proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74450", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13887", "l": "CO2 + stipitatate => H2O + stipitatonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34556", "l": "a (2S)-2-hydroxycarboxylate + NAD(+) => a 2-oxocarboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9726621", "l": "PGR binds PGR antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39642", "l": "(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA <=> (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15449", "l": "homogentisate + O2 = 4-maleylacetoacetate + H(+)", "d": []}, {"i": "EC:1.13.11.5", "l": "\"homogentisate 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514823", "l": "Fibrillin-1 degradation by ELANE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072571", "l": "mono-ADP-D-ribose binding", "d": ["Binding to monomeric ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67327", "l": "acetyl-CoA + ATP + 11 H(+) + L-serine + 7 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine <=> (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34534", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose <=> CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813626", "l": "LEAP2 binds bacteria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62107", "l": "(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635461", "l": "PtpA dephosphorylates GSK3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65545", "l": "ganglioside GM1 + H2O => an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18583", "l": "glycolaldehyde + H2O2 + NH4(+) => ethanolamine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10139", "l": "2 glyoxylate + H(+) <=> 2-hydroxy-3-oxopropanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41328", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710353", "l": "GSDMD (1-275) binds cardiolipin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32555", "l": "(2E)-geranyl diphosphate + H2O = (R)-alpha-terpineol + diphosphate", "d": []}, {"i": "EC:4.2.3.112", "l": "\"(+)-alpha-terpineol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73317", "l": "1D-chiro-inositol(in) + 2 Na(+)(in) => 1D-chiro-inositol(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41598", "l": "(5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38026", "l": "gamma-tocotrienol <=> 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483116", "l": "GPCho is hydrolyzed to Cho and G3P by GPCPD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39468", "l": "(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618093", "l": "ATP hydrolysis by HSP90 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42790", "l": "2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25603", "l": "2-(2-methylsulfanyl)ethylmalate + CoA + H(+) => 4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46213", "l": "H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine => 4-amino-5-aminomethyl-2-methylpyrimidine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-593685", "l": "Netrin-4 binds DCC/UNC5A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22372", "l": "H2O + O2 + propionate 3-nitronate = 3-oxopropanoate + H(+) + H2O2 + nitrite", "d": []}, {"i": "EC:1.7.3.5", "l": "\"3-aci-nitropropanoate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702629", "l": "sunitinib-resistant FLT3 mutants don't bind sunitinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602454", "l": "proMMP9 binds TIMP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49000", "l": "aurachin C + H(+) + NADH + O2 = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13944", "l": "ATP + D-glyceraldehyde <=> ADP + D-glyceraldehyde 3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174224", "l": "Dissociation of Cdc20 from APC/C complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69142", "l": "Recruitment of Dna2 endonuclease (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901149", "l": "salicylic acid binding", "d": ["Binding to salicylic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396009", "l": "STING binds c-di-GMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047931", "l": "glucosamine kinase activity", "d": ["Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39805", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56492", "l": "hederagenin + O2 + reduced [NADPH--hemoprotein reductase] = gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030144", "l": "alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3159253", "l": "MMAB adenosylates cob(I)alamin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74733", "l": "7,4'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine => rhamnetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56499", "l": "gypsogenin + O2 + reduced [NADPH--hemoprotein reductase] <=> gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024586", "l": "AT-RvD1-6 translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641229", "l": "TLE oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727297", "l": "mRNA7 is translated to protein 7a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.79713023523334", "identifiers": [{"i": "GO:0016413", "l": "O-acetyltransferase activity", "d": ["Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661217", "l": "MT1A binds zinc (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.15.1.-", "l": "\"Acting on superoxide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26040", "l": "beta-D-fructose 6-phosphate + GDP-alpha-D-mannose => beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32901", "l": "2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin] => 1,8-cineole + O2 + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67349", "l": "apigenin 7-O-beta-D-glucoside + malonyl-CoA => apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48166", "l": "H(+) + red chlorophyll catabolite => epoxypheophorbide a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061923", "l": "(2S,3R,6S,9S)-(-)-protoillud-7-ene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (2S,3R,6S,9S)-(-)-protoillud-7-ene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212356", "l": "Formation of CSL-NICD coactivator complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9623384", "l": "α1-agonists bind ADRA1A,B,D (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12500", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) = 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13813", "l": "benzene + H(+) + NADH + O2 = cis-1,2-dihydrobenzene-1,2-diol + NAD(+)", "d": []}, {"i": "EC:1.14.12.3", "l": "\"benzene 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44294", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710914", "l": "ALK fusions bind GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.4.-", "l": "\"With a disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28836", "l": "citrate(out) + succinate(in) => citrate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20901", "l": "H(+) + H2O + N-benzyloxycarbonylglycine => benzyl alcohol + CO2 + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047137", "l": "N-hydroxy-2-acetamidofluorene reductase activity", "d": ["Catalysis of the reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69587", "l": "GMP + inosine <=> guanosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17052", "l": "3-demethylubiquinol-9 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11397", "l": "5-methyldeoxycytidine 5'-phosphate + ATP => 5-methyldeoxycytidine diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65759", "l": "2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] <=> (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41967", "l": "butanoyl-CoA + O2 <=> (2E)-butenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190245", "l": "FGFR1b binds to FGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592398", "l": "Activation of proMMP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853444", "l": "AURKA phosphorylates PHLDA1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55424", "l": "(3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] = (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.59", "l": "\"dimethylnonatriene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0035256", "l": "G protein-coupled glutamate receptor binding", "d": ["Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798749", "l": "Exocytosis of specific granule lumen proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14279", "l": "(S)-lactate + 2 H(+) + NADH => (S)-lactaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592278", "l": "Autocatalytic activation of proMMP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197958", "l": "FPGS-2 transforms THF to THFPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34468", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + valerena-4,7(11)-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560802", "l": "Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004940", "l": "beta1-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11473", "l": "an N-methyl-L-amino acid + H2O + O2 => an L-alpha-amino acid + formaldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30253", "l": "2 a ubiquinone + n H(+)(out) + 2 H2O => 2 a ubiquinol + n H(+)(in) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44896", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45775", "l": "[(1->4)-beta-D-mannosyl](n) + phosphate <=> [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24343", "l": "(R,R)-butane-2,3-diol + NAD(+) <=> (R)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56824", "l": "AH2 + cyclooctat-9-ene-5,7-diol + O2 = A + cyclooctatin + H2O", "d": []}, {"i": "EC:1.14.99.62", "l": "\"cyclooctatin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40037", "l": "ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate => ATP + L-glutamate + N-acetyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49208", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.264", "l": "\"L-idonate 5-dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450494", "l": "HuR binds mRNAs in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58772", "l": "1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004142", "l": "diacylglycerol cholinephosphotransferase activity", "d": ["Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61851", "l": "cholesterol + UDP-alpha-D-glucose <=> cholesteryl 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611721", "l": "β1-agonists bind ADRB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36749", "l": "beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25276", "l": "ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691154", "l": "HFE binds TFRC dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396007", "l": "IRF3 is phosphorylated by TBK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43855", "l": "H(+) + malonyl-CoA + triacontanoyl-CoA <=> 3-oxo-dotriacontanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74362", "l": "coproporphyrin I(out) <=> coproporphyrin I(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451347", "l": "Activation of JNK by DSCAM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45997", "l": "a D-alpha-amino acid + a quinone + H2O => a 2-oxocarboxylate + a quinol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675198", "l": "Activated MAPKs phosphorylate BRAF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.825466069370655", "identifiers": [{"i": "GO:0001664", "l": "G protein-coupled receptor binding", "d": ["Binding to a G protein-coupled receptor."]}, {"i": "REACT:R-HSA-500717", "l": "Activation of GRIK3 homomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657637", "l": "ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42900", "l": "guanosine(745) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.187", "l": "\"23S rRNA (guanine(745)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35156", "l": "(S)-4,5-dihydroxypentane-2,3-dione => (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71900", "l": "3',5'-cyclic GMP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.246", "l": "\"4beta-methylsterol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11542", "l": "an N-acyl-D-mannosaminolactone + H(+) + NADH => an N-acyl-D-mannosamine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731018", "l": "SARS-CoV-1 M binds to PDPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818682", "l": "MEN1 binds MLL2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015184", "l": "L-cystine transmembrane transporter activity", "d": ["Enables the transfer of L-cystine from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730847", "l": "Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120295", "l": "histone serotonyltransferase activity", "d": ["Catalysis of the reaction: L-glutaminyl-[histone] + serotonin = 5-serotonyl-L-glutamyl-[histone] + NH4(+)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047815", "l": "D-arabinonolactonase activity", "d": ["Catalysis of the reaction: D-arabinono-1,4-lactone + H2O = D-arabinonate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799409", "l": "HIPK2 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953398", "l": "PIR oxygenates quercetin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69889", "l": "Na(+)(in) + uridine(in) => Na(+)(out) + uridine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38564", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + H2O => 1-O-hexadecyl-sn-glycerol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655142", "l": "RCHY1 binds POLH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354124", "l": "Phosphorylation of pPTK2 by SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.145", "l": "\"3beta-hydroxy-Delta(5)-steroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0106019", "l": "phosphatidylinositol-4,5-bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75856", "l": "Abortive Initiation Before Second Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62578", "l": "ADP + H(+) + L-cystine(in) + phosphate => ATP + H2O + L-cystine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804379", "l": "PRMT5 binds TTC5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51520", "l": "(S)-reticuline + S-adenosyl-L-methionine = (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.4.3", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047967", "l": "glycyrrhizinate beta-glucuronidase activity", "d": ["Catalysis of the reaction: glycyrrhizate + H2O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22059", "l": "hexadecan-1-ol + NAD(+) <=> H(+) + hexadecanal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010012", "l": "steroid 22-alpha hydroxylase activity", "d": ["Catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047958", "l": "glycine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111930", "l": "Adenylate cyclase produces cAMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41577", "l": "dTDP-beta-L-mycarose + erythronolide B => 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27746", "l": "H(+) + L-cysteine = CO2 + cysteamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19943", "l": "coclaurine + H(+) + S-adenosyl-L-homocysteine => norcoclaurine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788628", "l": "p-Y-STATs dissociate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23966", "l": "(E)-ferulate + 2 H(+) + NADPH => (E)-coniferaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784160", "l": "IL10 negatively regulates extracellular inflammatory mediators (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008928", "l": "mannose-1-phosphate guanylyltransferase (GDP) activity", "d": ["Catalysis of the reaction: alpha-D-mannose 1-phosphate + GDP + H+ = GDP-alpha-D-mannose + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045515", "l": "interleukin-18 receptor binding", "d": ["Binding to an interleukin-18 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029451", "l": "Activation of RAC1 by VAV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28105", "l": "GDP-alpha-D-mannose + H2O <=> D-mannose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21042", "l": "CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34392", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose => [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28922", "l": "4-aminobutanoate(in) + L-glutamate(out) <=> 4-aminobutanoate(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38728", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15741", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) = 2,5-dichlorohydroquinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708457", "l": "HM13 cleaves HMOX1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614544", "l": "Sulfite is oxidized to sulfate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453183", "l": "p-Y348-SYK dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76099", "l": "a dicarboxylate(in) + xanthurenate(out) = a dicarboxylate(out) + xanthurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2509827", "l": "ITPA hydrolyses ITP to IMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54278", "l": "(3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39257", "l": "(3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+) => (13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008684", "l": "TBK1 phosphorylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.74", "l": "\"fragilysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16710", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102812", "l": "4-coumaroyl-CoA:cyanidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + cyanidin 3-O-beta-D-glucoside betaine <=> cyanidin 3-(p-coumaroyl)-glucoside + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63781", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448673", "l": "Formation of caspase-1 p10/p20 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050073", "l": "macrolide 2'-kinase activity", "d": ["Catalysis of the reaction: ATP + oleandomycin = ADP + 2 H+ + oleandomycin 2'-O-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33189", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68140", "l": "2,5-hexanedione + 2 H(+) + 2 NADPH = (2R,5R)-hexanediol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70510", "l": "LDH tetramer oxidises LACT to PYR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875661", "l": "GGA3 associates with activated MET receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10536", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.10", "l": "\"chondro-6-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734475", "l": "PPARA binds fibrates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177930", "l": "GAB1 phosphorylation by EGFR kinase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654510", "l": "FGFRL1 binds SPRED1/2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67473", "l": "H2O + succinyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51343", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32350", "l": "2 S-adenosyl-L-methionine + tricetin <=> 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483142", "l": "PC is transphosphatidylated to PG by PLD1-4/6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35694", "l": "(2S)-versicolorone + NADP(+) <=> 1'-hydroxyversicolorone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66456", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450551", "l": "AUF1 binds translation and heat shock proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801666", "l": "PLK2 phosphorylates CENPJ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56011", "l": "4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879562", "l": "SLCO2B1 has a narrow substrate specificity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55973", "l": "acetyl-CoA + ethanol => CoA + ethyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465940", "l": "atRAL is reduced to atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73757", "l": "Binding of RRN3 to RNA Polymerase I (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76031", "l": "2 H2O2 => O2 + 2 H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9710959", "l": "p-STAT1 dimer binds KPNA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57501", "l": "3-hydroxybutane-1,2,3-tricarboxylate => 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618093", "l": "ATP hydrolysis by HSP90 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67907", "l": "glutaryl-CoA + H(+) + malonyl-[ACP] <=> 3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32926", "l": "H2O + sn-glycero-3-phospho-(1'-sn-glycerol) <=> glycerol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17630", "l": "alpha,alpha-trehalose(in) => alpha,alpha-trehalose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44245", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1470010", "l": "Dimerization of STATs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047945", "l": "L-glutamine:pyruvate aminotransferase activity", "d": ["Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253325", "l": "ERBB4s80 binds TAB2:NCOR1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75244", "l": "FASL binds FAS Receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8873946", "l": "OTUD3 deubiquitinates PTEN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769418", "l": "NPAS4 stimulates RET gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27310", "l": "naphthalene-1,2-diol + O2 = 2-hydroxychromene-2-carboxylate + H(+)", "d": []}, {"i": "EC:1.13.11.56", "l": "\"1,2-dihydroxynaphthalene dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75410", "l": "2-dehydro-D-glucose <=> cortalcerone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.92", "l": "\"oxaloglycolate reductase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5333671", "l": "CLCAs self cleave (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6804099", "l": "HMGB1 binds LTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57635", "l": "ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202111", "l": "AKT1 phosphorylates eNOS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954207", "l": "ERBB4s80:ESR1 binds CXCL12 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807826", "l": "LDHAL6B reduces PYR to LACT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006588", "l": "MECP2 binds the PTPN4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45501", "l": "phycocyanobilin-L-cysteinyl(84)-[allophycocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34333", "l": "(indol-3-yl)acetate + CO2 + H2O + NADP(+) => H(+) + indole-3-pyruvate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63908", "l": "ATP + H2O + pravastatin(in) = ADP + H(+) + phosphate + pravastatin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679266", "l": "Beclin-1 complex translocates to the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18937", "l": "an N-acyl-L-homoserine lactone + H2O = a carboxylate + L-homoserine lactone", "d": []}, {"i": "EC:3.5.1.97", "l": "\"acyl-homoserine-lactone acylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49745", "l": "deoxyviolaceinate + H(+) + O2 => CO2 + deoxyviolacein + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73133", "l": "7,8-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 8-hydroxy-7-methoxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031695", "l": "alpha-2B adrenergic receptor binding", "d": ["Binding to an alpha-2B adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103098", "l": "CYP79F1 tetrahomomethionine monooxygenase activity", "d": ["Catalysis of the reaction: 2 H+ + tetrahomomethionine + 2 O2 + 2 NADPH <=> 3 H2O + carbon dioxide + 2 NADP + 7-methylthioheptanaldoxime."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49131", "l": "AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102852", "l": "1-18:3-2-16:0-phosphatidylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-16:0-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54581", "l": "a 5'-end dephospho-ribonucleoside-RNA + ATP => a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22991", "l": "3-oxopropanoate + CoA + NADP(+) <=> acetyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.41", "l": "\"sterol 24-C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42092", "l": "all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25670", "l": "sucrose + UDP-alpha-D-galactose = H(+) + loliose + UDP", "d": []}, {"i": "EC:2.4.1.n2", "l": "\"loliose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34990", "l": "(S)-lactate(in) <=> (S)-lactate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17320", "l": "chlorophyllide a + H(+) + phytyl diphosphate <=> chlorophyll a + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71113", "l": "L-phenylalanine(in) + S-methylmercury-L-cysteine(out) => L-phenylalanine(out) + S-methylmercury-L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59966", "l": "CoA + O-octanoyl-L-seryl-[protein] => L-seryl-[protein] + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46316", "l": "GDP-N,N'-diacetylbacillosamine + H2O = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158849", "l": "Phenol can form a sulfate conjugate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050211", "l": "procollagen galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21564", "l": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA", "d": []}, {"i": "EC:2.3.1.16", "l": "\"acetyl-CoA C-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70647", "l": "D-serine(out) + H(+)(out) = D-serine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72476", "l": "cis-aconitate(in) + citrate(out) => cis-aconitate(out) + citrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649733", "l": "mature p21 RAS binds GDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34342", "l": "(22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033855", "l": "nicotianamine aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + nicotianamine = 3''-deamino-3''-oxonicotianamine + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951644", "l": "Release of mature NEDD8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168839", "l": "SHP1 (PTPN6) binds JAK2 in the receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18032", "l": "2 ATP + hydrogencarbonate + NH4(+) <=> 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614778", "l": "MAG gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30092", "l": "a ubiquinone + D-alanine + H2O => a ubiquinol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12788", "l": "an alditol + NAD(+) <=> an aldose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73363", "l": "beta-alanyl-[peptidyl-carrier protein] + dopamine = beta-alanyl-dopamine + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45868", "l": "9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160915", "l": "Receptor-mediated uptake of HA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45685", "l": "N-dodecanoyl-sphing-4-enine-1-phosphate(in) => N-dodecanoyl-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.20", "l": "\"S-sulfosulfanyl-L-cysteine sulfohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22955", "l": "O2 + octanedioyl-CoA <=> (2E)-octenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422088", "l": "Expression of Preproghrelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909729", "l": "Activation of JAK kinases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24927", "l": "H2O + L-cystine = NH4(+) + pyruvate + S-sulfanyl-L-cysteine", "d": []}, {"i": "EC:4.4.1.35", "l": "\"L-cystine beta-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66652", "l": "(2E,6E)-farnesyl diphosphate = african-1-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30731", "l": "butanoyl-CoA + FAD + H(+) = (2E)-butenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73334", "l": "(2R,3S)-piscidate + (E)-feruloyl-CoA <=> cimicifugate E + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444527", "l": "FPR is a receptor for formyl peptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48665", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51920", "l": "a quinone + AH2 = A + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75804", "l": "butanoate(out) + Na(+)(out) => butanoate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44280", "l": "2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA = 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004446", "l": "inositol-hexakisphosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18059", "l": "CO2 + hnu + oxidized Watasenia luciferin => O2 + Watasenia luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55775", "l": "a jasmonate + an L-alpha-amino acid + ATP <=> a jasmonyl-L-amino acid + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099567", "l": "calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration", "d": ["The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17274", "l": "(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) => 4-hydroxyphenylacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14601", "l": "L-lysine + O2 = 5-aminopentanamide + CO2 + H2O", "d": []}, {"i": "EC:1.13.12.2", "l": "\"lysine 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51440", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70934", "l": "chloride(out) + dopamine(out) + 2 Na(+)(out) <=> chloride(in) + dopamine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204773", "l": "Interaction of Tie2 and Grb7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53988", "l": "H2O + O-phospho-L-threonyl-[myosin light chain] = L-threonyl-[myosin light chain] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60344", "l": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.361", "l": "\"[histone H4]-lysine(20) N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5250947", "l": "B-WICH complex binds rDNA promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25434", "l": "beta-D-ribofuranose => beta-D-ribopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74740", "l": "Binding of SHC1 to insulin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047977", "l": "hepoxilin-epoxide hydrolase activity", "d": ["Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27474", "l": "ATP + D-glycero-beta-D-manno-heptose 7-phosphate => ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702570", "l": "KW2449-resistant FLT3 mutants don't bind KW2449 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417829", "l": "P2RY12 binds ADP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53313", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051430", "l": "corticotropin-releasing hormone receptor 1 binding", "d": ["Binding to a corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69901", "l": "2 Na(+)(in) + thymidine(in) => 2 Na(+)(out) + thymidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32244", "l": "alpha-D-ribose 1,5-bisphosphate => D-ribulose 1,5-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65953", "l": "2 a quinone + H(+) + NADH => 2 a 1,4-benzosemiquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174444", "l": "Formation of C-strand Okazaki fragments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48746", "l": "(-)-deoxypodophyllotoxin + CO2 + H2O + succinate => (-)-yatein + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204850", "l": "Interaction of Tie2 and Dok-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31438", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814695", "l": "PERP binds desmosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14617", "l": "CoA + glutathione + NADP(+) = CoA-glutathione + H(+) + NADPH", "d": []}, {"i": "EC:1.8.1.10", "l": "\"CoA-glutathione reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31386", "l": "(S)-2,3-epoxysqualene <=> lupeol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45975", "l": "3-oxochol-4-en-22-oate + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878054", "l": "HIPK2 phosphorylates RUNX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21143", "l": "ATP + inosine <=> ADP + H(+) + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74324", "l": "O-3-hydroxybutanoyl-(R)-carnitine(in) => O-3-hydroxybutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.3", "l": "\"plant seed peroxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043727", "l": "5-amino-4-imidazole carboxylate lyase activity", "d": ["Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate."]}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:1903763", "l": "gap junction channel activity involved in cell communication by electrical coupling", "d": ["Any gap junction channel activity that is involved in cell communication by electrical coupling."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42877", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448629", "l": "IL33 binds IL1RL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67303", "l": "(5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one <=> 3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71999", "l": "O2 + preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + preaspterpenacid acid II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392530", "l": "p-S400-Cot phosphorylates NIK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004998", "l": "transferrin receptor activity", "d": ["Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51909", "l": "dATP + H2O => dADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604722", "l": "Activation of proMMP9 by proteases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13311", "l": "2 H(+) + NADH + vanillate => H2O + NAD(+) + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24826", "l": "dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14612", "l": "D-sorbitol + NADP(+) <=> H(+) + keto-L-sorbose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56848", "l": "1,6-didemethyltoxoflavin + S-adenosyl-L-methionine = H(+) + reumycin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68703", "l": "16alpha,17beta-estriol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 16alpha,17beta-estriol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15050", "l": "GDP-alpha-D-glucose + H2O => D-glucose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52166", "l": "(R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56863", "l": "a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate <=> a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900756", "l": "NOTCH1 HD+PEST domain mutants bind JAG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60020", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + sesquisabinene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33158", "l": "a 1-acyl-sn-glycero-3-phosphate + H2O <=> a 1-acyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.9.-", "l": "\"With a copper protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25344", "l": "carbamate + NH4(+) => H2O + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177922", "l": "EGFR dimerization (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45692", "l": "N-(octanoyl)-sphing-4-enine-1-phosphate(in) = N-(octanoyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0018671", "l": "4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58256", "l": "H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] = ADP-D-ribose + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867047", "l": "PTPN3 dephosphorylates EPS15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139918", "l": "Phosphorylation of BIM by JNK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69055", "l": "H(+) + N(omega)-methyl-L-arginine + 2 NADH + 3 O2 <=> 3 H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445072", "l": "Interaction of PAK1 with Rac1-GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186785", "l": "PDGF-AA clevage by Furin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690701", "l": "SHP1 binds p-CD22 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168038", "l": "Collagen type XV restin release (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442732", "l": "NMDA-activated RASGRF1 activates RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24908", "l": "(E)-4-coumarate + NH4(+) => L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60294", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731072", "l": "SARS-CoV-1 3a tetramer induces potassium efflux (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399930", "l": "Activation of PAK by Rac1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38962", "l": "a 2,3-saturated acyl-CoA + O2 <=> a (2E)-enoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71013", "l": "L-isoleucine(out) + L-phenylalanine(in) => L-isoleucine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63336", "l": "alpha-D-xylose = beta-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016251", "l": "RNA polymerase II general transcription initiation factor activity", "d": ["A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73404", "l": "(2R,3R)-tartrate(in) + sulfate(out) => (2R,3R)-tartrate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12931", "l": "(2R)-homocitrate + CoA + H(+) => 2-oxoglutarate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610942", "l": "HCMV Formation of Final Envelopment Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191654", "l": "c-src associates with Cx43 in gap junctions (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12142", "l": "a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+) => a 2'-deoxyribonucleoside + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43809", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174121", "l": "Association of Securin with Cdc20:APC/C complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67921", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22187", "l": "(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) <=> acenaphthene-1,2-dione + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36050", "l": "A + D-glyceraldehyde + H2O <=> (R)-glycerate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35732", "l": "sn-glycerol 3-phosphate + tetradecanoyl-CoA => 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-912734", "l": "CBL:CRKL binds RAPGEF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805811", "l": "Release of SEPT4 from mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26015", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate => 3-dehydroquinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69202", "l": "ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[tubulin] + phosphate => ATP + gamma-L-glutamyl-L-glutamyl-[tubulin] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30597", "l": "3,4-dihydroxyphenylacetate + FAD + H(+) + H2O => 4-hydroxyphenylacetate + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11222", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42165", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 => (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0016889", "l": "DNA endonuclease activity, producing 3'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters."]}, {"i": "EC:3.1.22.-", "l": "\"Endodeoxyribonucleases producing other than 5'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357479", "l": "p-AXL binds PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51518", "l": "(R)-tembetarine + H(+) + S-adenosyl-L-homocysteine => (R)-reticuline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-217255", "l": "FMO1:FAD N-oxidises TAM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682465", "l": "RTC completes synthesis of the minus strand genomic RNA complement (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22190", "l": "a (2S)-2-hydroxycarboxylate + a halide anion + H(+) => an (R)-2-haloacid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14776", "l": "2 NADPH + palmatine + S-adenosyl-L-methionine <=> corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034658", "l": "isopropylmalate transmembrane transporter activity", "d": ["Enables the transfer of isopropylmalate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.36", "l": "\"signal peptidase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15742", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) => 2,5-dichlorohydroquinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.11", "l": "\"galactosylceramide sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50959", "l": "cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine <=> H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45266", "l": "(9Z,12Z)-octadecadienoate(in) => (9Z,12Z)-octadecadienoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52469", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate => 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54643", "l": "(+)-copalyl diphosphate <=> (12E)-labda-8(17),12,14-triene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71053", "l": "L-leucine(in) + L-methionine(out) => L-leucine(out) + L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53885", "l": "CDP-alpha-D-glucose + D-glucose 6-phosphate => alpha,alpha-trehalose 6-phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52321", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryptamine => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56652", "l": "12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604731", "l": "Autocatalytic activation of MMP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65188", "l": "2-oxoglutarate + berkeleyone B + O2 = berkeleydione + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45273", "l": "12-phosphooxy-(9Z)-octadecenoate + H2O => 12-hydroxy-(9Z)-octadecenoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708408", "l": "DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46802", "l": "Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31172", "l": "(3S)-hydroxytetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26284", "l": "Co-precorrin-5A + H2O <=> acetaldehyde + Co-precorrin-5B + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.06379513530257", "identifiers": [{"i": "GO:0016717", "l": "oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water."]}, {"i": "EC:1.14.19.-", "l": "\"With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27947", "l": "dopamine + H2O + O2 => 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9732527", "l": "FFAR1 binds rosiglitazone (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23155", "l": "a ubiquinone + H(+) + NADH <=> a ubiquinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63334", "l": "beta-L-arabinopyranose => alpha-L-arabinopyanose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686930", "l": "RIPK3 is cleaved by CASP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37531", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0009019", "l": "tRNA (guanine-N1-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50495", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0016538", "l": "cyclin-dependent protein serine/threonine kinase regulator activity", "d": ["Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins."]}, {"i": "REACT:R-HSA-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15001", "l": "keto-L-sorbose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.123", "l": "\"sorbose 5-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418200", "l": "SRC-1 bound to ARRB2 is not activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19304", "l": "histamine + S-adenosyl-L-methionine <=> H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18386", "l": "acetone + 2 ATP + 3 H2O + hydrogencarbonate => acetoacetate + 2 AMP + 4 H(+) + 4 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873929", "l": "Casein kinase II phosphorylates STARD10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20614", "l": "3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine => adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186798", "l": "GAP binds to PDGF-beta receptors only (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39772", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602473", "l": "Autocatalytic activation of MMP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37794", "l": "aclacinomycin A + O2 <=> aclacinomycin Y + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55067", "l": "4-methylpentanoyl-CoA + H2O <=> 4-methylpentanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604294", "l": "Gamma-secretase cleaves NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23813", "l": "(+)-neomenthol + NADP(+) => (1R,4S)-menthone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047050", "l": "(S)-2-hydroxy-fatty acid dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxystearate + NAD+ = 2-oxostearate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45687", "l": "N-dodecanoyl-sphing-4-enine-1-phosphate(in) <=> N-dodecanoyl-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48292", "l": "ganglioside GM1 + GDP-beta-L-fucose = ganglioside Fuc-GM1 + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685605", "l": "SLAMF7 binds SLAMF7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24328", "l": "7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + phosphate", "d": []}, {"i": "EC:6.3.4.17", "l": "\"formate--dihydrofolate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030735", "l": "carnosine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013108", "l": "GDIs block activation of RHOC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937369", "l": "ATAD2 binds ESR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69724", "l": "(indol-3-yl)acetyl-AMP + CoA => (indol-3-yl)acetyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23724", "l": "H2O + O2 + pyridoxal = 4-pyridoxate + H(+) + H2O2", "d": []}, {"i": "EC:1.2.3.8", "l": "\"pyridoxal oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614605", "l": "Persulfide sulfur is dioxygenated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58397", "l": "4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67210", "l": "5-methoxytryptamine + acetate => H2O + melatonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51292", "l": "a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(S)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13688", "l": "lathosterol + NADP(+) <=> 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809944", "l": "PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68894", "l": "3-methoxybenzaldehyde + AMP + diphosphate + NADP(+) => 3-methoxybenzoate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047676", "l": "arachidonate-CoA ligase activity", "d": ["Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38195", "l": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75322", "l": "chloride(out) + D-alanine(out) + 2 Na(+)(out) <=> chloride(in) + D-alanine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65635", "l": "a sphingoid base + tetracosanoyl-CoA <=> an N-tetracosanoyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56926", "l": "ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein] => ATP + L-threonyl-[Goodpasture antigen-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-453183", "l": "p-Y348-SYK dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68691", "l": "3'-phosphoadenylyl sulfate + 3beta-androst-5-en-17-one 3-O-(beta-D-glucuronate) <=> 3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050255", "l": "ribitol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-ribitol + NAD+ = D-ribulose + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37947", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13726", "l": "acetyl-CoA + alpha-D-glucosamine 1-phosphate => CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18173", "l": "(R)-octopamine = (4-hydroxyphenyl)acetaldehyde + NH4(+)", "d": []}, {"i": "EC:4.2.1.87", "l": "\"octopamine dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39985", "l": "a 2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O => a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47588", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E)) = CMP + ganglioside GQ1c (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5623643", "l": "RDH13 reduces atRAL to atROL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612246", "l": "ERBB4s80 binds the APOE gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19077", "l": "H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] = 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34460", "l": "8-hydroxycopalyl diphosphate + H2O => diphosphate + sclareol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483087", "l": "PI is exchanged with PC by PITPNB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27816", "l": "acetate(out) + Na(+)(out) => acetate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60372", "l": "D-fructose(out) = D-fructose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046509", "l": "1,2-diacylglycerol 3-beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-sn-glycerol + UDP-D-galactose = 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433955", "l": "Phosphorylation of IKKs complex by activated TAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40528", "l": "2 a ubiquinol + 4 H(+)(in) + O2(in) => 2 a ubiquinone + 4 H(+)(out) + 2 H2O(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56320", "l": "a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose = an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20875", "l": "(20S)-ginsenoside Rd + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rb1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706315", "l": "Active FLT3 binds to SH2B3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928639", "l": "p-EFNB binds GRB4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.19", "l": "\"prokaryotic ubiquitin-like protein ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43868", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in) = a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432909", "l": "Interaction of Plectin with Integrin beta 4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102201", "l": "(+)-2-epi-prezizaene synthase activity", "d": ["Catalysis of the reaction: 2-cis,6-trans-farnesyl diphosphate <=> (+)-2-epi-prezizaene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050692", "l": "DNA binding domain binding", "d": ["Binding to a protein's DNA binding domain (DBD)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30441", "l": "2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46582", "l": "25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015362", "l": "high-affinity sodium:dicarboxylate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}, {"i": "REACT:R-HSA-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23597", "l": "H2O + 2 NAD(+) + UDP-alpha-D-glucose => 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23456", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = A + crepenynate + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671702", "l": "AP1G2 binds HGS and CHMP2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44678", "l": "a diacylglycerol + an all-trans-retinyl ester => a triacyl-sn-glycerol + all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26339", "l": "H(+) + 2 L-methionine => L-homocysteine + S-methyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190256", "l": "FGFR1c binds to FGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170796", "l": "NPC transports GCK1:GKRP from cytosol to nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21179", "l": "L-idonate + NADP(+) <=> 5-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189488", "l": "UROS transforms HMB to URO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114361", "l": "SMAC binds XIAP within apoptosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950201", "l": "Expression of Aryl Hydrocarbon receptor-interacting protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51787", "l": "4-prenylphlorisovalerophenone + dimethylallyl diphosphate <=> deoxyhumulone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8856951", "l": "PP2A demethylation by PPME1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229343", "l": "AXIN is phosphorylated in the destruction complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869568", "l": "NPM1 binds TFAP2A homodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164520", "l": "Minus strand DNA synthesis resumes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944454", "l": "mTORC1 phosphorylates MAF1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53635", "l": "(2E,6E)-farnesyl diphosphate <=> (3S)-(+)-asterisca-2(9),6-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174235", "l": "Association of Emi1 with Cdc20 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018756", "l": "RHOH binds GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618328", "l": "ATAT acetylates microtubules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9627104", "l": "XIAP binds CASP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373747", "l": "Phosphorylation of nephrin by FYN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19781", "l": "2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate", "d": []}, {"i": "EC:2.6.1.24", "l": "\"diiodotyrosine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57325", "l": "acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] => CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.126", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72733", "l": "UDP-alpha-D-glucose(out) + UMP(in) => UDP-alpha-D-glucose(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36794", "l": "H2O + N(omega)-hydroxy-L-arginine <=> hydroxyurea + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217136", "l": "Phosphorylation of Chk1 by ATM upon DNA damage (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33756", "l": "H2O + N-hexadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9604308", "l": "NICD4 traffics to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865275", "l": "PDGF-BB clevage by Furin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73596", "l": "dCMP + H2O => dUMP + NH4+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31749", "l": "3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH => 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351894", "l": "Caspase mediated cleavage of BAP31 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018774", "l": "RHOBTB1 binds GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17795", "l": "H(+) + L-alanine + tRNA(Thr) => H2O + L-alanyl-tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75213", "l": "Cu(+)(in) => Cu(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63434", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) => 1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0016411", "l": "acylglycerol O-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033520", "l": "TYSND1 cleaves TYSND1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70411", "l": "4-hydroxyphenylacetyl-CoA + H2O = 4-hydroxyphenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1011598", "l": "DOCKs bind to RhoGEFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69686", "l": "daidzein 7-O-beta-D-glucoside + H2O <=> beta-D-glucose + daidzein + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18578", "l": "3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine => 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39417", "l": "(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+) => (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-383190", "l": "HCO3- transport through ion channel (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61216", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097109", "l": "neuroligin family protein binding", "d": ["Binding to a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63748", "l": "UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan-2-N-beta-D-glucuronide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357472", "l": "PAK1-3 autophosphorylates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874082", "l": "MET phosphorylates PTK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034479", "l": "phosphatidylglycerol phospholipase C activity", "d": ["Catalysis of the reaction: a phosphatidylglycerol + H2O = 1,2-diacylglycerol + glycerol 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483218", "l": "PG transports from the ER membrane to the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199062", "l": "KLRC1:KLRD1 heterodimer interacts with HLA-E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389083", "l": "Autophosphorylation of PDGF alpha receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72418", "l": "Li(+)(in) + Na(+)(out) <=> Li(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950367", "l": "Expression of transaldolase 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202233", "l": "Inactivation of Lck by Csk (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31743", "l": "a 4'-hydroxyflavanone + S-adenosyl-L-methionine = a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.231", "l": "\"flavonoid 4'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0050119", "l": "N-acetylglucosamine deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosamine + H2O = D-glucosamine + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52823", "l": "L-serine + succinyl-CoA <=> CoA + O-succinyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45521", "l": "phycoviolobilin-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71100", "l": "androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) => androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66757", "l": "ATP + domoate(in) + H2O => ADP + domoate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63209", "l": "5-amino-6-(D-ribitylamino)uracil + glyoxal => 5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39689", "l": "(2E,11Z)-octadecadienoyl-CoA + H2O => (R)-3-hydroxy-(11Z)-octadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43114", "l": "H(+) + NADH + phenylglyoxylate => (R)-mandelate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15857", "l": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+) = 17alpha-hydroxyprogesterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44971", "l": "(2E)-tetradecenoyl-CoA + H(+) + NADPH <=> NADP(+) + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878056", "l": "RUNX1:CBFB binds EP300 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43553", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749253", "l": "Formation of MCM2-7 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2314678", "l": "ASA- acetylates PTGS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49231", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) <=> diphosphate + geranylgeranyl-bacteriochlorophyllide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50728", "l": "(Z)-(4-hydroxyphenyl)acetaldehyde oxime = 4-hydroxyphenylacetonitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30594", "l": "H2O + O2 + tyramine <=> (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44638", "l": "2,4-dinitrophenol + H(+) + methanol => 2,4-dinitroanisole + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791082", "l": "Expression of Calreticulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70376", "l": "3-oxosphinganine + dodecanoyl-CoA => CoA + H(+) + N-dodecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66433", "l": "H(+)(out) + L-galactose(out) => H(+)(in) + L-galactose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53676", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61683", "l": "ATP + holo-[peptidyl-carrier protein] + L-cysteine <=> AMP + diphosphate + L-cysteinyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66482", "l": "gypsogenin 28-beta-D-glucoside + UDP => gypsogenin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696465", "l": "USP45 deubiquitinates ERCC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382053", "l": "Translocation of PDGF from ER to Golgi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17900", "l": "A + ethylbenzene + H2O <=> (S)-1-phenylethanol + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0016662", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome."]}, {"i": "EC:1.7.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52450", "l": "16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha-hydroxyestrone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10984", "l": "(S)-lactate + oxaloacetate = (S)-malate + pyruvate", "d": []}, {"i": "EC:1.1.99.7", "l": "\"lactate--malate transhydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55353", "l": "all-trans-retinol => 13-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213208", "l": "Type X collagen associates with collagen type II fibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38336", "l": "(20S)-ginsenoside Rb1 + 2 H2O => (20S)-ginsenoside Rg3 + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43174", "l": "N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine => guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709406", "l": "CO binds to Cytochrome c oxidase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018809", "l": "E-phenylitaconyl-CoA hydratase activity", "d": ["Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63369", "l": "ATP + H2O + spermine(out) => ADP + H(+) + phosphate + spermine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12239", "l": "H2O + NADP(+) + nicotinate <=> 6-hydroxynicotinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48067", "l": "ganglioside GD1b (d18:1(4E)) + H2O <=> ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13804", "l": "3 H2O + hydrogen sulfide + 3 NADP(+) <=> 4 H(+) + 3 NADPH + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26213", "l": "9alpha-copalyl diphosphate + H2O = aphidicolan-16beta-ol + diphosphate", "d": []}, {"i": "EC:4.2.3.42", "l": "\"aphidicolan-16beta-ol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37476", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56036", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73566", "l": "dGDP(out) + UTP(in) <=> dGDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047794", "l": "cyclohexadienyl dehydrogenase activity", "d": ["Catalysis of the reaction: L-arogenate + NAD+ = L-tyrosine + NADH + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72319", "l": "n chloride(in) + urate(out) = n chloride(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164519", "l": "RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29415", "l": "(S)-lactate(in) + H(+)(in) = (S)-lactate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60563", "l": "L-methionyl-[protein] + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336184", "l": "GPR37L binds prosaposin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004904", "l": "interferon receptor activity", "d": ["Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297354", "l": "Acrosin Cleavage (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168412", "l": "MDP elicits a NOD2 response (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12200", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 = CO2 + mugineate + succinate", "d": []}, {"i": "EC:1.14.11.24", "l": "\"2'-deoxymugineic-acid 2'-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36787", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine = N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}, {"i": "EC:2.7.8.40", "l": "\"UDP-N-acetylgalactosamine-undecaprenyl-phosphate N-acetylgalactosaminephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395517", "l": "NADPH transfers electrons to FDXR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15960", "l": "D-altronate <=> 2-dehydro-3-deoxy-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6791235", "l": "GADD45A binds AURKA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085083", "l": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166792", "l": "Conversion of C2 into C2a and C2b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218806", "l": "FYN autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19355", "l": "cholate + glycine => glycocholate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047278", "l": "bilirubin-glucuronoside glucuronosyltransferase activity", "d": ["Catalysis of the reaction: 2 bilirubin-glucuronoside = bilirubin + bilirubin-bisglucuronoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9734730", "l": "ORC1 translocates to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373717", "l": "DCC interacts with DIP13alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445367", "l": "CaMKII binds activated NMDA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57807", "l": "1-chloro-3-nitrobenzene + NADH + O2 <=> 4-chlorocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28245", "l": "O2 + pratensein + reduced [NADPH--hemoprotein reductase] <=> 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034834", "l": "2-mercaptobenzothiazole dioxygenase activity", "d": ["Catalysis of the reaction: 2-mercaptobenzothiazole + O2 + 2 H+ + 2 e- = 2-mercaptobenzothiazole-cis-6,7-dihydrodiol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.18", "l": "\"aspergillopepsin I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034016", "l": "polyenoic fatty acid isomerase activity", "d": ["Catalysis of the reaction: all-cis-icosa-5,8,11,14,17-pentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13715", "l": "a ubiquinol + fumarate => a ubiquinone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213195", "l": "Formation of anchoring fibrils (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47249", "l": "2 Fe(III)-[cytochrome c] + L-gulono-1,4-lactone => 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008772", "l": "[isocitrate dehydrogenase (NADP+)] kinase activity", "d": ["Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53063", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate <=> estrone 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33990", "l": "(+)-copalyl diphosphate <=> diphosphate + neoabietadiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16109", "l": "ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.11", "l": "\"6-phosphofructokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20863", "l": "(1S,6R)-isopiperitenol + NAD(+) <=> (6R)-isopiperitenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27852", "l": "CoA + H(+) + phenylacetylglycine => glycine + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12495", "l": "L-methionine <=> D-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50071", "l": "ATP + glycoursodeoxycholate(in) + H2O <=> ADP + glycoursodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417842", "l": "P2Y10 receptor can bind to LPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29059", "l": "2 H(+)(in) + H2 + ubiquinone-8 = 2 H(+)(out) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.701260003289605", "identifiers": [{"i": "GO:0005179", "l": "hormone activity", "d": ["The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20864", "l": "alpha,alpha-trehalose 6-phosphate + phosphate = beta-D-glucose 1-phosphate + D-glucose 6-phosphate", "d": []}, {"i": "EC:2.4.1.216", "l": "\"trehalose 6-phosphate phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851908", "l": "Activated MET binds GAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10414", "l": "AMP + D-ribose 5-phosphate + 2 H(+) => ADP-D-ribose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51444", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine = H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22675", "l": "2 (2E,6E)-farnesyl diphosphate <=> diphosphate + presqualene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55860", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11518", "l": "CoA + H(+) + succinate => H2O + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18881", "l": "ATP + histamine + L-glutamate = ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate", "d": []}, {"i": "EC:6.3.2.18", "l": "\"gamma-glutamylhistamine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.3.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30681", "l": "beta-D-glucose + D-glucose => D-cellobiose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047774", "l": "cis-2-enoyl-CoA reductase (NADPH) activity", "d": ["Catalysis of the reaction: acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66389", "l": "ATP + H2O + prostaglandin E2(in) => ADP + H(+) + phosphate + prostaglandin E2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74734", "l": "Re-integration of insulin receptor into plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373074", "l": "Receptor CCR9  binds CCL25 ligand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29901", "l": "ADP + D-xylose(in) + H(+) + phosphate => ATP + D-xylose(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68013", "l": "H2O + hypoxanthine + O2 => H2O2 + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21085", "l": "chondroitin 4'-sulfate => dermatan 4'-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66270", "l": "AMP + H(+) + nonanoyl-CoA => CoA + nonanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928604", "l": "SFKs phosphorylate VAV2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013158", "l": "CDC42 GDIs block activation of CDC42 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66854", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate => (2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140825", "l": "lactoperoxidase activity", "d": ["Catalysis of the reaction: 2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392064", "l": "G alpha (z) inhibits adenylate cyclase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183126", "l": "Factor B binds to surface-associated C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40685", "l": "1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0001069", "l": "regulatory region RNA binding", "d": ["Binding to a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878054", "l": "HIPK2 phosphorylates RUNX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061627", "l": "S-methylmethionine-homocysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34704", "l": "(2E,6E)-farnesyl diphosphate => (E)-2-epi-beta-caryophyllene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30987", "l": "(S)-2,3-epoxysqualene = (17Z)-protosta-17(20),24-dien-3beta-ol", "d": []}, {"i": "EC:5.4.99.32", "l": "\"protostadienol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15710", "l": "kaempferol + UDP-alpha-D-galactose => H(+) + kaempferol 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660665", "l": "Caspase-8 binds MALT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55319", "l": "3 H2O + hydrogen sulfide + 3 NAD(+) <=> 4 H(+) + 3 NADH + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58477", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55219", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + rhizathalene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14040", "l": "4,5beta-dihydrocortisone + NADP(+) <=> cortisone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75293", "l": "glyoxylate(out) + oxalate(in) => glyoxylate(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37517", "l": "1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52988", "l": "[deoxyhypusine synthase]-L-lysine + dehydrospermidine = [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388811", "l": "CD28 homodimer binds B7-1 homodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59133", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP => AMP + diphosphate + H(+) + staphyloferrin B", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102615", "l": "ent-cassadiene-C2-hydroxylase activity", "d": ["Catalysis of the reaction: ent-cassa-12,15-diene + NADPH + O2 + H+ <=> 2alpha-hydroxy-ent-cassadiene + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54157", "l": "2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 => [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48848", "l": "(9Z,12Z)-octadecadienoate + O2 = 13-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24375", "l": "H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] <=> H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75665", "l": "10,11-epoxy-12-hydroxy-(14Z)-eicosenoate => 12-hydroperoxy-(10E,14Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.110", "l": "\"ureidoacrylate amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70569", "l": "2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59630", "l": "4-aminobutanoate + L-arginine => H2O + N(2)-(4-aminobutanoyl)-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16942", "l": "N-acetylindoxyl + O2 => H2O + N-acetylisatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10932", "l": "ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.4.5", "l": "\"argininosuccinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75862", "l": "Fall Back to Closed Pre-initiation Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19493", "l": "D-cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose", "d": []}, {"i": "EC:2.4.1.20", "l": "\"cellobiose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17251", "l": "6 H(+) + 2 iron(III) oxide-hydroxide => 2 Fe(2+) + 2 H2O + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176318", "l": "Loading of claspin onto DNA during replication origin firing (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67410", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + thymol => gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74738", "l": "S-adenosyl-L-methionine + syringetin <=> 7,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48812", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69376", "l": "2-hydroxydodecanoate + O2 = 2-oxododecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0030971", "l": "receptor tyrosine kinase binding", "d": ["Binding to a receptor that possesses protein tyrosine kinase activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018571", "l": "2,3-dihydroxy-p-cumate dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxy-p-cumate + O2 = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42744", "l": "guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.174", "l": "\"23S rRNA (guanine(1835)-N(2))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698928", "l": "Late (L) Gene Expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34288", "l": "2 L-dopa + O2 => 2 H2O + 2 L-dopaquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60671", "l": "(R,R)-chrysanthemol + NAD(+) <=> (1R,3R)-chrysanthemal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180885", "l": "Rev multimer-bound HIV mRNA associates with Crm1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018861", "l": "4-chlorobenzoate-CoA ligase activity", "d": ["Catalysis of the reaction: 4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate. This reaction requires magnesium and is part of the bacterial 2,4-dichlorobenzoate degradation pathway."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671972", "l": "CIT binds CDKN1B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51275", "l": "(9Z)-octadecenoyl-CoA + glycine <=> CoA + H(+) + N-(9Z-octadecenoyl)glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39804", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) => (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49161", "l": "1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] => 2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57086", "l": "a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295613", "l": "SPRY2 binds GRB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31761", "l": "dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5334827", "l": "SUMO-CRABP2 binds atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130731", "l": "Formation of COPII vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755303", "l": "26S proteasome degrades HIFalpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.23", "l": "\"dUTP diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592362", "l": "Activation of proMMP7 by MMP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38668", "l": "sphing-4-enine 1-phosphate(in) => sphing-4-enine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59379", "l": "4-amino-4-deoxychorismate <=> 4-amino-4-deoxyprephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66977", "l": "alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose => alpha-D-Abe-(1->3)-alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647746", "l": "EML4 trimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39470", "l": "(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH <=> (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66218", "l": "asc-DeltaC7-CoA + H2O2 => asc-C7-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176956", "l": "Formation of GINS complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54211", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 <=> 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004099", "l": "chitin deacetylase activity", "d": ["Catalysis of the reaction: chitin + H2O = chitosan + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64431", "l": "glycyl-L-proline(out) + H(+)(out) <=> glycyl-L-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.49", "l": "\"RNA-directed DNA polymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16614", "l": "acetyl-CoA + an arylamine => an N-acetylarylamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72740", "l": "chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out) => chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55732", "l": "19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984609", "l": "Kinesin-8 is a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44189", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638006", "l": "ARL3 hydrolyzes GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68943", "l": "Na(+)(in) + tellurite(in) <=> Na(+)(out) + tellurite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140932", "l": "5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity", "d": ["Catalysis of the reaction: a 5'-end (N2,N2,N7-trimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H+ + N7-methyl-GMP. Can also use (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA as a substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62893", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA => 6 CO2 + 7 CoA + 2 H2O + nor-toralactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72691", "l": "Formation of the 43S pre-initiation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60252", "l": "(S)-methylmalonyl-CoA + NADP(+) = acryloyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351207", "l": "Spermine  => N-acetylated spermine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73291", "l": "H(+)(out) + L-valine(in) = H(+)(in) + L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875558", "l": "RAPGEF1 binds CRK,CRKL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061652", "l": "FAT10 conjugating enzyme activity", "d": ["Isoenergetic transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y = Y-FAT10 + X, where both the X-FAT10 and Y-FAT10 linkages are thioester bonds between the C-terminal amino acid of FAT10 and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48255", "l": "ganglioside GD2 + UDP-alpha-D-galactose <=> ganglioside GD1b + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25362", "l": "(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] <=> biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27757", "l": "H2O + methylglyoxal <=> (R)-lactate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33739", "l": "2 H(+) + hexadecanoate + NADH = H2O + hexadecanal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9817575", "l": "ERO1B oxidizes P4HB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75485", "l": "estrone 3-sulfate(in) + n H(+)(in) => estrone 3-sulfate(out) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694428", "l": "LMAN family proteins bind glycosylated cargo (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987043", "l": "IL22RA1 binds JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62264", "l": "hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) = hydrogencarbonate(in) + selenite(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25054", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749609", "l": "BCHE hydrolyzes ASA- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.706056554619465", "identifiers": [{"i": "GO:0004722", "l": "protein serine/threonine phosphatase activity", "d": ["Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417890", "l": "P2Y5 receptor can bind to LPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41260", "l": "L-tryptophan => (E)-3-(indol-3-yl)acrylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23165", "l": "a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose => a flavonol 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66705", "l": "H2O + mycophenolyl-CoA => CoA + H(+) + mycophenolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57745", "l": "[protein]-disulfide + phylloquinol => [protein]-dithiol + phylloquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54472", "l": "1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869580", "l": "DEK binds TFAP2A homodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.81", "l": "\"ADAM10 endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39236", "l": "(3R)-hydroxytriacontanoyl-CoA => (2E)-triacontenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12314", "l": "2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+) => dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35566", "l": "H2O + N-(9Z-hexadecenoyl) ethanolamine <=> (9Z)-hexadecenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52708", "l": "GMP + H2O = D-ribose 5-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11080", "l": "dTMP + H2O = phosphate + thymidine", "d": []}, {"i": "EC:3.1.3.35", "l": "\"thymidylate 5'-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56871", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA <=> (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34103", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}, {"i": "EC:5.1.3.26", "l": "\"N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029453", "l": "Phosphorylation of VAV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19046", "l": "acetyl-CoA + H2O + pyruvate => (3R)-citramalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047199", "l": "phosphatidylcholine-dolichol O-acyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + dolichol = 1-acyl-sn-glycero-3-phosphocholine + acyldolichol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22126", "l": "acetate + ajmaline + H(+) => 17-O-acetylajmaline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419861", "l": "Melanospin is stimulated by light (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15861", "l": "3-ADP-2-phosphoglycerate + H2O = 3-ADP-glycerate + phosphate", "d": []}, {"i": "EC:3.1.3.28", "l": "\"ADP-phosphoglycerate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.201", "l": "\"exo-chitinase (reducing end)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12470", "l": "26-desgluco-avenacoside A + D-glucose => avenacoside A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15387", "l": "3-cyano-L-alanine + H2O => L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.30", "l": "\"coccolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624951", "l": "TNPO1 binds KIF17 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75758", "l": "(10E)-octadecenoate + H2O <=> 10-hydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51921", "l": "a quinone + AH2 => A + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31017", "l": "CO2 + indole => H(+) + indole-3-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202472", "l": "Translocation of TRAF6 to CBM complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41502", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23104", "l": "D-arabinose 5-phosphate = D-ribulose 5-phosphate", "d": []}, {"i": "EC:5.3.1.13", "l": "\"arabinose-5-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13865", "l": "GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol = beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.142", "l": "\"chitobiosyldiphosphodolichol beta-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13856", "l": "4-methylene-L-glutamate + ATP + NH4(+) <=> 4-methylene-L-glutamine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018774", "l": "RHOBTB1 binds GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102988", "l": "9,12-cis-hexadecadienoic acid delta 15 desaturase activity", "d": ["Catalysis of the reaction: (9Z,12Z)-hexadecadienoyl-CoA + O2 + a reduced electron acceptor <=> 9,12,15-cis-hexadecatrienoyl-CoA + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51100", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56685", "l": "dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65978", "l": "previtamin D3 => 7-dehydrocholesterol + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689000", "l": "AADAC deacetylates PHEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65383", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004588", "l": "orotate phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43671", "l": "ATP + hexacosanoyl-CoA + hydrogencarbonate <=> 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352921", "l": "1,3-bisphosphoglycerate + NADH + H+ <=> glyceraldehyde 3-phosphate + NAD+ + phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2247513", "l": "STAB1:ligand is endocytosed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61133", "l": "(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + kaempferol + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71031", "l": "L-cysteine(in) + L-phenylalanine(out) = L-cysteine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67001", "l": "2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + phlorisobutanophenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757698", "l": "PREDN,PREDL diffuse into hepatic cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14385", "l": "a dolichyl diphosphate + H2O = a dolichyl phosphate + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.43", "l": "\"dolichyldiphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31023", "l": "squalene = dammara-20,24-diene", "d": []}, {"i": "EC:5.4.99.37", "l": "\"dammaradiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11386", "l": "2-oxooctadecanoate + H(+) + NADH => (S)-2-hydroxyoctadecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110215", "l": "Cleavage of uracil by UNG glycosylase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70804", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate => 4-deoxy-4-sulfo-D-erythrose + D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63925", "l": "ATP + N(4)-acetylcytidine => ADP + H(+) + N(4)-acetylcytidine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10786", "l": "CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052688", "l": "(3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity", "d": ["Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + AMP + diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA."]}, {"i": "KEGG.REACTION:R06515", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2484882", "l": "Collagen type X degradation by MMP3, 13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33731", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981657", "l": "IL34 dimer binds PTPRZ1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73615", "l": "CTP(out) + dCMP(in) = CTP(in) + dCMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62543", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabain <=> dihydroouabain + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26231", "l": "geranylgeranyl diphosphate + 3 H(+) + 3 NADPH => 3 NADP(+) + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0010420", "l": "3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708812", "l": "ELAC2 cleaves pre-tRNA to yield 3' trailer (type II tRF or tRF-1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43875", "l": "3-oxochol-4-en-22-oate + ATP + CoA <=> 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63380", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629358", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419389", "l": "LPA-binding receptors bind LPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36407", "l": "ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate", "d": []}, {"i": "EC:2.7.7.87", "l": "\"L-threonylcarbamoyladenylate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45064", "l": "H2O + N-hexadecanoylethanolamine = ethanolamine + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013985", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990644", "l": "microtubule site clamp", "d": ["The binding activity of a molecule that attaches the spindle microtubules to the kinetochore."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947647", "l": "GHSR is a receptor for ghrelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12278", "l": "3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] => 3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062062", "l": "oligosaccharyltransferase complex binding", "d": ["Binding to an oligosaccharyltransferase complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72346", "l": "3-methoxyphenol + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) <=> methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + resorcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12152", "l": "(3R,4S,5S,6R)-pentachlorocyclohexene = (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786101", "l": "IL4 binds IL4R:JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203979", "l": "Coat Assembly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18296", "l": "ATP + CoA + oxalate <=> AMP + diphosphate + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381086", "l": "Dissociation of PERK:BiP Heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9671145", "l": "DKC1 binds SHQ1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29032", "l": "L-glutamate(in) + 2 Na(+)(in) => L-glutamate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211272", "l": "FOXOA2-, MAFA-, and PAX6-dependent synthesis of PDX1 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17647", "l": "N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate => H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38887", "l": "H2O + N-hexanoyl-sphinganine = hexanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19578", "l": "luteolin + UDP-alpha-D-glucose => H(+) + luteolin 7-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034882", "l": "cis-aconitamide amidase activity", "d": ["Catalysis of the reaction: cis-aconitamide + H2O = cis-aconitate + HN3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36434", "l": "a purine 2'-deoxy-D-ribonucleoside + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389841", "l": "MTFMT formylates methionyl-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47998", "l": "H2O2 + NAD(+) => 1,6-dihydro-beta-NAD + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.50", "l": "\"noroxomaritidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14434", "l": "a tRNA precursor + ATP + 2 CTP => a tRNA with a 3' CCA end + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47079", "l": "17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH <=> 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23463", "l": "benzyl cetraxate + H2O <=> benzyl alcohol + cetraxate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60417", "l": "diglucosyl-enterobactin + H2O => H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40977", "l": "2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.7", "l": "\"plasmin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52357", "l": "3'-phosphoadenylyl sulfate + pregnenolone => adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73097", "l": "AMP(in) + CoA(out) => AMP(out) + CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22144", "l": "cis-aconitate + H2O = D-threo-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30276", "l": "AH2 + H2O2 => A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683888", "l": "LMCD1 binds GATA6, sequestering it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47393", "l": "H2O + hexadecanoate ester => an aliphatic alcohol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182988", "l": "Sprouty lures CBL away from EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674022", "l": "BRAP autoubiquitinates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45872", "l": "15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72297", "l": "malate(in) + 3 Na(+)(in) => malate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000074", "l": "TCN2 binds RCbl in the circulation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955712", "l": "SVBP:VASH1,VASH2 hydrolyzes the terminal L-Tyr residue from alphaY-beta tubulin dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9821366", "l": "AKAP8L binds MLL2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31238", "l": "(4S)-4-hydroxy-L-glutamate + 2-oxoglutarate <=> (4R)-4-hydroxy-2-oxoglutarate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39250", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA <=> (2E,11Z)-eicosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63308", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9007539", "l": "CHEK1 phosphorylates E2F6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004512", "l": "inositol-3-phosphate synthase activity", "d": ["Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48022", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose => globoside Gb3Cer + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22776", "l": "2 H(+) + H2O2 + 2 Mn(2+) = 2 H2O + 2 Mn(3+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61436", "l": "ADP + H2O = AMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33339", "l": "(4R)-hydroxysphinganine + hexacosanoyl-CoA = CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3772430", "l": "CTNNBIP1 binds beta-catenin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016971", "l": "flavin-dependent sulfhydryl oxidase activity", "d": ["Catalysis of the reaction: [protein]-dithiol + O2 = [protein]-disulfide + H2O2 using FAD as a cofactor, leading to formation of disulfide bridges in proteins."]}, {"i": "RHEA:59116", "l": "[protein]-dithiol + O2 = [protein]-disulfide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21281", "l": "H2O + 2 O2 + thiamine => H(+) + 2 H2O2 + thiamine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34017", "l": "ergosterol + 2 H2O + NADP(+) => ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29703", "l": "L-valine(in) = L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12831", "l": "mesaconate + NH4(+) => (2S,3S)-3-methyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727869", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to HNRNPA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676599", "l": "sBAFF trimer binds BAFFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201717", "l": "CSNK2-mediated phosphorylation of DVL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050357", "l": "tropinesterase activity", "d": ["Catalysis of the reaction: atropine + H2O = H+ + tropate + tropine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193964", "l": "CYP21A2 21-hydroxylates PROG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018826", "l": "RHOT2 hydrolyzes GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626928", "l": "CREBBP binds FOXO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12462", "l": "fumarate + H2O => (S)-malate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43761", "l": "acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17207", "l": "adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate => 3'-phosphoadenylyl sulfate + quercetin 3-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050085", "l": "mannitol 2-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-mannitol + NADP+ = D-fructose + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16005", "l": "galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O", "d": []}, {"i": "EC:4.2.1.42", "l": "\"galactarate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.67", "l": "\"endopeptidase So\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.14", "l": "\"5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25962", "l": "benzil + H(+) + NADPH => benzoin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430311", "l": "Rsu-1 interacts with Pinch1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102761", "l": "eriodictyol 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine <=> H+ + homoeriodictyol + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11979", "l": "anhydrotetracycline + H(+) + NADPH + O2 <=> 5a,11a-dehydrotetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015420", "l": "ABC-type vitamin B12 transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: vitamin B12(out) + ATP + H2O = ADP + an vitamin B12(in) + H+ + phosphate. Vitamin B12 is alkylcob(III)alamin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47007", "l": "H2O + O-phospho-L-threonyl-[protein] <=> L-threonyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032775", "l": "YAP1 binds TEAD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38484", "l": "a 2,3-diacyl-sn-glycerol + H2O => a 2-acylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72888", "l": "O2 + polyporic acid + reduced [NADPH--hemoprotein reductase] => ascocorynin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604722", "l": "Activation of proMMP9 by proteases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51836", "l": "(9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23800", "l": "H2O + L-methionine = 2-oxobutanoate + methanethiol + NH4(+)", "d": []}, {"i": "EC:4.4.1.11", "l": "\"methionine gamma-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189406", "l": "4 PBGs bind to form HMB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9689680", "l": "IFNG dimer binds IFNG inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20534", "l": "H2O + pyridoxal 5'-phosphate => phosphate + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27877", "l": "isochorismate <=> pyruvate + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50301", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28936", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => oxaloacetate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11955", "l": "3-hydroxypyruvate <=> 2-hydroxy-3-oxopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088134", "l": "PLK1 phosphorylates FOXM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68166", "l": "H(+) + 2 H2O + N-(8'-oxogeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase] => N-(8'-hydroxygeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36003", "l": "(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate", "d": []}, {"i": "EC:4.1.3.43", "l": "\"4-hydroxy-2-oxohexanoate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875558", "l": "RAPGEF1 binds CRK,CRKL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47862", "l": "ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate => ganglioside GT1b (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640862", "l": "Tankyrase binds AXIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046422", "l": "violaxanthin de-epoxidase activity", "d": ["Catalysis of the reaction: violaxanthin + 2 ascorbate = zeaxanthin + 2 dehydroascorbate + 2 H2O; and antheraxanthin + ascorbate = zeaxanthin + dehydroascorbate + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0017168", "l": "5-oxoprolinase (ATP-hydrolyzing) activity", "d": ["Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H2O = L-glutamate + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61505", "l": "pelargonidin + UDP-alpha-D-glucose => pelargonidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55489", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299318", "l": "Activation of TASK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031527", "l": "Expression of APOC2 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27511", "l": "7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine => dehydro coenzyme F420-0 + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67970", "l": "H(+) + phosphate + presqualene monophosphate => H2O + presqualene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13243", "l": "ADP + beta-L-fucose 1-phosphate + H(+) => ATP + L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372697", "l": "Crk binding to p130cas (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54419", "l": "5alpha-campestan-3-one + NADP(+) <=> campest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010280", "l": "UDP-L-rhamnose synthase activity", "d": ["Catalysis of the reaction: UDP-D-glucose + NADPH + H+ = UDP-L-rhamnose + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31486", "l": "soyasapogenol E + UDP-alpha-D-glucuronate <=> H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53145", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0016713", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190519", "l": "Internalization of gap junction plaques (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23922", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate => (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050161", "l": "succinyl-CoA:oxalate CoA-transferase", "d": ["Catalysis of the reaction: oxalate + succinyl-CoA = oxalyl-CoA + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25458", "l": "diphosphate + gamma-humulene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30707", "l": "putrescine + pyruvate = 4-aminobutanal + L-alanine", "d": []}, {"i": "EC:2.6.1.113", "l": "\"putrescine--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51140", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 = (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578965", "l": "TNRC6A binds AGO2:miRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047882", "l": "estradiol 6-beta-monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + estradiol-17beta + O2 = 6beta-hydroxyestradiol-17beta + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615015", "l": "FOXO6 binds PLXNA4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102840", "l": "1-18:2-2-16:3-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-16:3-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73846", "l": "a 27-hydroxysterol + UDP-alpha-D-glucose <=> a sterol 27-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29593", "l": "H(+) + NADPH + sulfoacetaldehyde => 2-hydroxyethane-1-sulfonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614544", "l": "Sulfite is oxidized to sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189062", "l": "lactose + H2O => D-glucose + D-galactose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163320", "l": "Association of mTERF with the termination sequence (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3095889", "l": "MMACHC dealkylates RCbl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692764", "l": "MAPK6 binds CCND3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560510", "l": "Expression of FABP4 (aP2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37366", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 <=> 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18941", "l": "a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) = a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.413", "l": "\"A-factor type gamma-butyrolactone 1'-reductase (1S-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15795", "l": "biliverdin IXalpha + H(+) + NADPH => bilirubin IXalpha + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19993", "l": "[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60928", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986940", "l": "MET gene transcription is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981606", "l": "Myoglobin binds oxygen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66024", "l": "hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen] = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68046", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9645598", "l": "RRAGC,D hydrolyzes GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59531", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein] <=> CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106263", "l": "1-acylglycerophosphoserine O-acyltransferase activity", "d": ["Catalysis of the reaction:a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA."]}, {"i": "RHEA:33191", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA", "d": []}, {"i": "EC:2.3.1.n6", "l": "\"1-acylglycerophosphoserine O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18798", "l": "a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3159259", "l": "MMAA:MUT binds AdoCbl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49348", "l": "2,2-dihydroxyspirilloxanthin = 2-oxospirilloxanthin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28988", "l": "H(+)(in) + N-acetylneuraminate(in) => H(+)(out) + N-acetylneuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450474", "l": "MK2 phosphorylates BRF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080133", "l": "midchain alkane hydroxylase activity", "d": ["Catalysis of the conversion of an alkane to a secondary alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190263", "l": "FGFR3b binds to FGF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211924", "l": "CYP4B1 12-hydroxylates ARA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51178", "l": "5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19771", "l": "H2O + phaseollidin => phaseollidin hydrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685318", "l": "BCDX2 complex formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17410", "l": "(S)-coclaurine + S-adenosyl-L-methionine => (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32333", "l": "(1S,4R)-fenchone + H(+) + NADH => (1S,2S,4R)-endo-fenchol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59545", "l": "N,N'-diacetylchitobiose + O2 => H2O2 + N,N'-diacetylchitobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30877", "l": "6-amino-2-oxohexanoate + D-glutamate => 2-oxoglutarate + D-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9633742", "l": "EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46697", "l": "a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine => an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0005524", "l": "ATP binding", "d": ["Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator."]}, {"i": "REACT:R-HSA-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050527", "l": "poly(3-hydroxyoctanoate) depolymerase activity", "d": ["Catalysis of the reaction: H2O + poly[(R)-3-hydroxyoctanoate](n) = poly[(R)-3-hydroxyoctanoate](x) + poly[(R)-3-hydroxyoctanoate](n-x); x is 1-5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67541", "l": "(9Z)-hexadecenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0047555", "l": "3',5'-cyclic-GMP phosphodiesterase activity", "d": ["Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38488", "l": "1-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421459", "l": "uroporphyrinogen I => coproporphyrinogen I + 4 CO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62833", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0070513", "l": "death domain binding", "d": ["Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32969", "l": "a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16136", "l": "H2O + N(1)-acetylspermine + O2 <=> 3-aminopropanal + H2O2 + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694677", "l": "ZCRB1 binds 5'UTR of SARS-CoV-2 genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10160", "l": "L-iditol + NAD(+) = H(+) + keto-L-sorbose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901584", "l": "tetrapeptide transmembrane transporter activity", "d": ["Enables the transfer of tetrapeptide from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936963", "l": "IRAK2 induces TRAF6 oligomerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30764", "l": "H2O + L-valine + NAD(+) => 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72960", "l": "(R)-3-hydroxybutanoate(out) + 2 Na(+)(out) => (R)-3-hydroxybutanoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.178", "l": "\"2-dehydro-3-deoxyglucono/galactono-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354173", "l": "Activation of Rap1 by cytosolic GEFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2530429", "l": "Formation of soluble VTN:C5b-C9  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.24", "l": "\"tubulin-glutamate carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70333", "l": "3-hydroxyphenylacetate + CoA + H(+) => 3-hydroxyphenylacetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.195", "l": "\"cinnamyl-alcohol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49842", "l": "(-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+) => (-)-dehydrodiconiferyl acid + 2 a quinone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20623", "l": "ADP + H(+) + phosphate + Zn(2+)(out) => ATP + H2O + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30104", "l": "2,5-didehydro-D-gluconate + H(+) + NADH => 5-dehydro-D-gluconate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62233", "l": "a thymidine(6-4)thymidine in DNA => a thymidine dimer in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69257", "l": "H2O + progoitrin => (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71076", "l": "L-arginine(in) + L-cystine(out) => L-arginine(out) + L-cystine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46448", "l": "2 L-tyrosyl-tRNA(Tyr) = cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)", "d": []}, {"i": "EC:2.3.2.21", "l": "\"cyclo(L-tyrosyl-L-tyrosyl) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72631", "l": "Ca(2+)(in) + 3 Li(+)(out) = Ca(2+)(out) + 3 Li(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23306", "l": "H(+) + tropate + tropine => atropine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3076905", "l": "Extracellular BTD hydrolyses BCTN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390930", "l": "5-HT2 receptor can bind serotonin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72641", "l": "1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine => 1,6-dihydroxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106144", "l": "fraxetin 5-hydroxylase activity", "d": ["Catalyzes the reaction fraxetin+ NAD(P)H + 02= sideretin + NAD(P)(+) + H20."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047390", "l": "glycerophosphocholine cholinephosphodiesterase activity", "d": ["Catalysis of the reaction: sn-glycero-3-phosphocholine + H2O = choline phosphate + glycerol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4411373", "l": "NLK translocates to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60466", "l": "2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => 2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13542", "l": "H2O + tetrathionate => H(+) + sulfate + sulfur + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11683", "l": "ATP + H2O + L-glutamine + XMP <=> AMP + diphosphate + GMP + 2 H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34686", "l": "alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O <=> alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36857", "l": "acetate + an S-substituted L-cysteine => an N-acetyl-L-cysteine-S-conjugate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39423", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA = (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23558", "l": "gamma-L-glutamyl-D-alanine + NH4(+) => D-alanine + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50288", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.57", "l": "\"phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109639", "l": "Formation of the closed pre-initiation complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.17", "l": "\"4-hydroxy-4-methyl-2-oxoglutarate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29215", "l": "fumarate + menaquinol-8 = menaquinone-8 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809707", "l": "MTMR12 binds MTMR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876472", "l": "NPC2 binds CHOL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40713", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate => 1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507719", "l": "p62:MEKK3 binds to TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821486", "l": "HCFC1 binds SET1A complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18398", "l": "ATP + L-glutamate + tRNA(Glx) => AMP + diphosphate + L-glutamyl-tRNA(Glx)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14961", "l": "H2O + S-formylglutathione = formate + glutathione + H(+)", "d": []}, {"i": "EC:3.1.2.12", "l": "\"S-formylglutathione hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24525", "l": "20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67513", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.1.14", "l": "\"6-deoxy-6-sulfo-D-fructose transaldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71253", "l": "L-xylulose => L-xylopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62759", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031708", "l": "endothelin B receptor binding", "d": ["Binding to an endothelin B receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32602", "l": "7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> 3-isopropenyl-6-oxoheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14549", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + formate + H(+)", "d": []}, {"i": "EC:3.7.1.9", "l": "\"2-hydroxymuconate-6-semialdehyde hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202328", "l": "Translocation of PKC theta to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015430", "l": "ABC-type glycerol-3-phosphate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-3-phosphate(out) = ADP + phosphate + glycerol-3-phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617595", "l": "SGTA binds mislocalized membrane protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112042", "l": "Opioid binds MOR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12250", "l": "H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine => NADP(+) + UDP-N-acetyl-alpha-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75983", "l": "(indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-yl)acetate(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050120", "l": "N-acetylhexosamine 1-dehydrogenase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosamine + H2O + NAD+ = N-acetyl-D-glucosaminate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70879", "l": "L-glutamine(in) + L-threonine(out) + Na(+)(out) = L-glutamine(out) + L-threonine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140750", "l": "nucleosome array spacer activity", "d": ["A histone octamer slider activity that spaces nucleosomes along chromosomal DNA. This activity is involved in assembling chromatin in uniform nucleosome arrays to regulate transcription by RNA polymerases I, II, and III, as well as DNA replication, recombination and repair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420128", "l": "SRC-1 phosphorylates SHB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69207", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + L-glutamate <=> ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76040", "l": "(S)-cis-N-methyltetrahydrothalifendine + O2 + reduced [NADPH--hemoprotein reductase] => 7-hydroxy-8-methoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.0(4,9).0(16,20)]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449115", "l": "IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134954", "l": "DHX9 binds DNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25920", "l": "A + H2O + quinolin-7-ol = 7-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44680", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508451", "l": "PTK2B is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56965", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate => a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68146", "l": "ethyl (R)-3-hydroxybutanoate + NADP(+) => ethyl 3-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004504", "l": "peptidylglycine monooxygenase activity", "d": ["Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66209", "l": "(8R)-8-hydroxynonanoyl-CoA + O2 => (2E,8R)-8-hydroxynonenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10510", "l": "aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate => D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34907", "l": "molybdate(in) = molybdate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43389", "l": "1D-myo-inositol 3,4-bisphosphate + H2O => 1D-myo-inositol 3-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14162", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 => 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42597", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => prostaglandin G2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37178", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12675", "l": "a nitrile + H2O => an aliphatic amide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008901", "l": "ferredoxin hydrogenase activity", "d": ["Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944242", "l": "Association of procollagen type XXVII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029471", "l": "Hydrolysis of PC to PA by PLD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912396", "l": "NICD1 binds HIF1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71829", "l": "arsenate(out) + H(+)(out) => arsenate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654569", "l": "Activated FGFR1 binds FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44488", "l": "3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047235", "l": "sucrose 6F-alpha-galactotransferase activity", "d": ["Catalysis of the reaction: sucrose + UDP-galactose = 6F-alpha-D-galactosylsucrose + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376419", "l": "Formation of NR-MED1 Coactivator Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16094", "l": "(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27873", "l": "(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31345", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54188", "l": "H2O + N-acetyl-L-phenylalanine = acetate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47065", "l": "4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088307", "l": "FOXM1 binds CCNB1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48162", "l": "epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69725", "l": "(indol-3-yl)acetyl-CoA + AMP + H(+) => (indol-3-yl)acetyl-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799246", "l": "CHEK1 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395439", "l": "Phosphorylation of DAP12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21810", "l": "glycylglycine => 2,5-dioxopiperazine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018765", "l": "2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: cis,cis-2-hydroxy-6-oxohept-2,4-dienoate + OH- = cis-2-hydroxypenta-2,4-dienoate + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928604", "l": "SFKs phosphorylate VAV2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418904", "l": "A1 and A3 receptors bind adenosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37984", "l": "gamma-tocopherol => 2,3-dimethyl-6-phytylbenzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928604", "l": "SFKs phosphorylate VAV2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10988", "l": "H2O + nitrous oxide = 2 e(-) + 2 H(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351948", "l": "Mitochondrial recruitment of Drp1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937792", "l": "RUNX3 binds SRC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73624", "l": "CTP(out) + GDP(in) => CTP(in) + GDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5387386", "l": "Hh processing variants are recruited to SEL1:SYVN at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65472", "l": "2-methylbutanoyl-CoA + ethanol = CoA + ethyl 2-methylbutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68701", "l": "16alpha,17beta-estriol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 16alpha,17beta-estriol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43208", "l": "5-(carboxymethyl)uridine(34) in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.229", "l": "\"tRNA (carboxymethyluridine(34)-5-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340214", "l": "CYGB binds O2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66025", "l": "hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen] => [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32917", "l": "sn-glycero-3-phospho-1D-myo-inositol(in) => sn-glycero-3-phospho-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141437", "l": "Formation of the MCC complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68147", "l": "ethyl 3-oxobutanoate + H(+) + NADPH <=> ethyl (R)-3-hydroxybutanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392064", "l": "G alpha (z) inhibits adenylate cyclase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32710", "l": "(2E)-geranyl diphosphate <=> (2R,4S)-bornyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31190", "l": "(3S)-hydroxydecanoyl-CoA + NAD(+) <=> 3-oxodecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41730", "l": "18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23063", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP <=> a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932070", "l": "ESR1 binds the AXIN1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-606349", "l": "Mis18 complex binds the centromere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102134", "l": "(22S)-22-hydroxy-campesterol C-23 hydroxylase activity", "d": ["Catalysis of the reaction: H+ + (22S)-22-hydroxycampesterol + NADPH + O2 <=> (22R,23R)-22,23-dihydroxycampesterol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74382", "l": "2 (S)-lactate(in) + prostaglandin H2(out) <=> 2 (S)-lactate(out) + prostaglandin H2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683774", "l": "p-T68-CHEK2 dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63946", "l": "an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+) => a fatty acyl-CoA + sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800042", "l": "TP53 binds the IGFBP3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14192", "l": "D-tryptophan + O2 <=> N-formyl-D-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23128", "l": "4-hydroxybutanoate + ATP + CoA = 4-hydroxybutanoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.40", "l": "\"4-hydroxybutyrate--CoA ligase (AMP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33212", "l": "1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+) => 2-demethylmenaquinol-7 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47551", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oate <=> 3-oxochola-4,6-dien-24-oate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31395", "l": "15-cis-4,4'-diapophytoene + FAD + H(+) = all-trans-4,4'-diapophytofluene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51431", "l": "acetyl-CoA + aminomethylphosphonate <=> 2-N-acetamidomethylphosphonate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532678", "l": "Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875374", "l": "MET binds LRIG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20878", "l": "(E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein] => (R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77081", "l": "Formation of the CE:GMP intermediate complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247839", "l": "Retromer associates with WLS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30358", "l": "a quinol + methane + O2 <=> a quinone + H2O + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36253", "l": "(E)-feruloyl-CoA + AMP + diphosphate => (E)-ferulate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4837364", "l": "Secretion of SOD3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23661", "l": "4-imidazolone-5-propanoate + H2O => N-formimidoyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74355", "l": "a cytidine in mRNA + H(+) + H2O = a uridine in mRNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.94", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39597", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+) => (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28201", "l": "(S)-1-phenylethanol + NAD(+) <=> acetophenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42738", "l": "H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735505", "l": "Expression of SRF in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19446", "l": "2,3-dihydroxyindole + O2 => anthranilate + CO2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39962", "l": "1-hexadecanoylglycerol + H2O <=> glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37676", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69254", "l": "2-(thiiran-2-yl)acetonitrile + sulfate => (Z)-N-(sulfonatooxy)prop-2-enimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73945", "l": "FAS-mediated dimerization of procaspase-8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42373", "l": "16-methoxytabersonine + H2O => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70859", "l": "L-asparagine(in) + L-glutamine(out) + Na(+)(out) = L-asparagine(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114254", "l": "CYCS binds to APAF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12925", "l": "D-erythrose 4-phosphate + L-lysyl-[protein] = H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69489", "l": "O2 + tetradecan-1-ol => H2O2 + tetradecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660660", "l": "p300 acetylates RELA subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68595", "l": "ORC2 binds ORC3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61775", "l": "rebaudioside E + UDP-alpha-D-glucose <=> H(+) + rebaudioside D + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701485", "l": "Active ALK binds JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865276", "l": "PDGF-AB clevage by Furin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61269", "l": "H2O + L-2-aminohexanoate + O2 => 2-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53271", "l": "L-ribulose <=> L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.3", "l": "\"2-acetolactate mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30993", "l": "24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.-", "l": "\"Carbon-sulfur lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686088", "l": "CASP3 cleaves GSDMD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46728", "l": "(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247840", "l": "WLS binds WNT ligands in the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50662", "l": "2-(2-methylsulfanyl)propylmaleate + H2O => 3-(3-methylsulfanyl)propylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36431", "l": "a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60271", "l": "N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047085", "l": "hydroxyphenylacetonitrile 2-monooxygenase activity", "d": ["Catalysis of the reaction: 4-hydroxyphenylacetonitrile + H+ + NADPH + O2 = 4-hydroxymandelonitrile + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757688", "l": "SERPINA6 binds PREDN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11338", "l": "deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48529", "l": "ganglioside GP1c (d18:1(4E)) + H2O => ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29137", "l": "a menaquinone + 2 H(+)(out) + H2O + nitrite => a menaquinol + 2 H(+)(in) + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40765", "l": "(20S)-ginsenoside Rg1 + L-rhamnopyranose => (20S)-ginsenoside Re + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64661", "l": "a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] => a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72045", "l": "L-glutamate(out) + orotate(in) => L-glutamate(in) + orotate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68746", "l": "8 AMP + 8 diphosphate + 8 H(+) + PF1022A + 4 S-adenosyl-L-homocysteine => 2 (R)-3-phenyllactate + 2 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418874", "l": "Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40175", "l": "O2 + octanoyl-CoA = (2E)-octenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17866", "l": "5,6,7,8-tetrahydropteridine + NADP(+) => 6,7-dihydropteridine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218815", "l": "p-6Y-VEGFR2 binds NCK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56302", "l": "[thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein] => [thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928631", "l": "GIT1 binds bPIX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0140789", "l": "histone phosphatase activity", "d": ["Catalysis of the reaction: a phosphorylated histone + H2O = a protein + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55348", "l": "all-trans-retinol = 9-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57155", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 <=> (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38209", "l": "estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37870", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA <=> 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354073", "l": "Autophosphorylation of PTK2 at Y397 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37497", "l": "1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336184", "l": "GPR37L binds prosaposin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27494", "l": "S-adenosyl-L-methionine + tricetin => 3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46396", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (11E)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.24", "l": "\"acyl-CoA 11-(E)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634402", "l": "Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390846", "l": "D2D3,4 bind to DA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51437", "l": "acetyl-CoA + D-alanine => (2R)-2-amino-4-oxopentanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29227", "l": "H(+)(in) + indole(in) = H(+)(out) + indole(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25487", "l": "(2E)-geranyl diphosphate <=> (1S,4R)-camphene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0000332", "l": "template for synthesis of G-rich strand of telomere DNA activity", "d": ["Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27540", "l": "4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde => ethanol + N,N-dimethyl-4-nitrosoaniline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757574", "l": "ALB binds PREDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46106", "l": "corticosterone + H2O + 2 oxidized [adrenodoxin] => 21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39635", "l": "3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46832", "l": "4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH = 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186785", "l": "PDGF-AA clevage by Furin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213201", "l": "Formation of collagen fibres (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29549", "l": "2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP => H2O + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48764", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) = 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50397", "l": "(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA => 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10157", "l": "dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] => 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0019210", "l": "kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669240", "l": "FLNA binds PAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48420", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) = CMP + ganglioside GM1 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10559", "l": "D-glyceraldehyde 3-phosphate + L-arginine <=> H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65258", "l": "A + H2O + verruculide C epoxide => AH2 + O2 + verruculide C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57549", "l": "(S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase] => [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102906", "l": "7-epi-alpha-selinene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> (-)-7-epi-alpha-selinene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299297", "l": "Activation of THIK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69906", "l": "cytidine(out) + 2 Na(+)(out) <=> cytidine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0004691", "l": "cAMP-dependent protein kinase activity", "d": ["cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54468", "l": "1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48231", "l": "a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] <=> a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625540", "l": "Cys-sulfenyl chloride is converted to Cys-sulfenic acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74451", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52909", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + O2 => 3-dimethylallyl-4-hydroxymandelate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71017", "l": "4-methylaminobutanal + H2O2 + NH4(+) => H2O + N-methylputrescine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804253", "l": "MDM2 ubiquitinates JMY (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16013", "l": "ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)", "d": []}, {"i": "EC:6.1.1.14", "l": "\"glycine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052630", "l": "UDP-N-acetylgalactosamine diphosphorylase activity", "d": ["Catalysis of the reaction: UTP + N-acetyl-alpha-D-galactosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-galactosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759334", "l": "NFE2L2 binds the SRXN1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42391", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose <=> beta-D-gentiobiosyl crocetin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429441", "l": "SYK activation by SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27972", "l": "alpha-D-glucose + D-maltose => D-maltotriose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63747", "l": "UDP-alpha-D-glucuronate + zolasartan <=> UDP + zolarsartan-1-N-beta-D-glucuronide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43570", "l": "3,6-anhydro-L-galactonate + 2 H(+) + NADH => 3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15099", "l": "(6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate => 5-formimidoyltetrahydrofolate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14163", "l": "3-(methylsulfanyl)propanoate + CO + formate + 2 H(+) => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52332", "l": "2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] = 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53096", "l": "4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682020", "l": "MRN complex binds shortened telomeres (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62774", "l": "N-acetyl-L-phenylalanine => N-acetyl-D-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47827", "l": "H(+) + malonyl-[ACP] + octadecanoyl-[ACP] <=> 3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9651467", "l": "SERPING1 variant does not bind kallikrein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26259", "l": "dehydroabietadienal + 2 H2O + NADP(+) => dehydroabietadienol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14328", "l": "7,8-dihydroxycoumarin + UDP-alpha-D-glucose <=> daphnin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31071", "l": "(S)-methylmalonate semialdehyde + L-alanine = (S)-3-amino-2-methylpropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50107", "l": "taurine + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0030566", "l": "snRNA modification guide activity", "d": ["Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0030611", "l": "arsenate reductase activity", "d": ["Catalysis of the interconversion of arsenate and arsenite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693243", "l": "RHOD translocates to the Golgi membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050568", "l": "protein-glutamine glutaminase activity", "d": ["Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72647", "l": "Cap-bound mRNA is activated by helicases  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051120", "l": "hepoxilin A3 synthase activity", "d": ["Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20381", "l": "androsterone + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035715", "l": "chemokine (C-C motif) ligand 2 binding", "d": ["Binding to chemokine (C-C motif) ligand 2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52981", "l": "a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] => 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.688704758796746", "identifiers": [{"i": "GO:0004396", "l": "hexokinase activity", "d": ["Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19259", "l": "a ketone + H(+) + NADPH => a secondary alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3858482", "l": "DVL is recruited to the receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809663", "l": "Formation of hair keratin fibres (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16892", "l": "2-oxoglutarate + 6-acetamido-3-aminohexanoate <=> 6-acetamido-3-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9615348", "l": "AGT(34-41) binds to AGTR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5633051", "l": "EFCAB7:IQCE binds EVC2:EVC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41570", "l": "aclacinomycin S + dTDP + H(+) => aclacinomycin T + dTDP-2-deoxy-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70668", "l": "a fatty acyl-[ACP] + L-lysyl-[protein] => H(+) + holo-[ACP] + N(6)-(fatty acyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49453", "l": "a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O => 6-sulfo-alpha-D-quinovose + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754644", "l": "SARS-CoV-2 E pentamer binds TJP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932599", "l": "CALB1 binds 4xCa2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749494", "l": "IKBIP binds IKBKB and CHUK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11030", "l": "ADP + D-mannose 6-phosphate + H(+) => ATP + D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008068", "l": "extracellularly glutamate-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45089", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-606287", "l": "RSF complex binds the centromere (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12757", "l": "dihydrozeatin + NADP(+) = H(+) + NADPH + zeatin", "d": []}, {"i": "EC:1.3.1.69", "l": "\"zeatin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23695", "l": "(R)-malate <=> H2O + maleate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36122", "l": "gibberellin A9 + S-adenosyl-L-methionine <=> O-methyl gibberellin A9 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56185", "l": "globoside Gb4Cer + UDP-alpha-D-galactose => globoside NOR1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18390", "l": "alpha-D-xylose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67899", "l": "a 3'-end uridylyl-adenosine-RNA <=> a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140769", "l": "factor VII -> factor VIIa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702601", "l": "midostaurin-resistant FLT3 mutants don't bind midostaurin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25545", "l": "ent-copalyl diphosphate => diphosphate + ent-pimara-9(11),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070139", "l": "SUMO-specific endopeptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046025", "l": "precorrin-6Y C5,15-methyltransferase (decarboxylating) activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59006", "l": "dodecanoate + H(+) + H2O2 => dodecanal + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692867", "l": "HRH3 binds pitosilant (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44455", "l": "3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112703", "l": "PTPN11 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59554", "l": "H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone => N,N',N'',N'''-tetraacetylchitotetraose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16161", "l": "2 Fe(III)-[leghemoglobin] + NADH = 2 Fe(II)-[leghemoglobin] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354060", "l": "Translocation of RIAM to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047365", "l": "quercetin-3-sulfate 3'-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H+ + quercetin 3,3'-disulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5221061", "l": "TDG excises 5-carboxylcytosine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17024", "l": "(2-aminoethyl)phosphonate + pyruvate <=> L-alanine + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68742", "l": "7alpha-hydroxycholesterol + NADP(+) => 7-oxocholesterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444047", "l": "Receptor FFAR3 binds carboxylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16859", "l": "an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60743", "l": "(S)-(-)-citronellal + H2O + NADP(+) <=> (S)-(-)-citronellate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430135", "l": "p-SLP-76 binds ADAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034914", "l": "trinitrophenol hydride denitratase activity", "d": ["Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex = 2,4-dinitrophenol + nitrite. Trinitrophenol is also known as TNP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55227", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940554", "l": "MMP2 cleaves OPTC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357479", "l": "p-AXL binds PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686483", "l": "Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59073", "l": "AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56497", "l": "gypsogenin + O2 + reduced [NADPH--hemoprotein reductase] => gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0072532", "l": "tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity", "d": ["Catalysis of the meta-hydroxylation of any of the three phenolic rings on triferuloyl spermidine or any of its mono- or di-(hydroxyferuloyl)-spermidine derivatives."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14034", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol => 1D-myo-inositol 1-phosphate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12526", "l": "Delta(1)-piperideine-2-carboxylate + H(+) + NADPH => L-pipecolate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791016", "l": "SFTPB binds itself (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46618", "l": "(23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin] => calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0018271", "l": "biotin-protein ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48903", "l": "chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70481", "l": "TPI1 isomerizes GA3P to DHAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71164", "l": "homogentisate + O2 => maleylacetoacetate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730841", "l": "Phosphorylation and activation of VAV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9668335", "l": "CHMP7 binds LEMD2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247836", "l": "Retromer recycles WLS to the Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008478", "l": "FBXW7 binds RUNX2 and GSK3B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61286", "l": "(2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+) => H2O + L-cystine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44886", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+) => a cardiolipin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65317", "l": "2-oxoglutarate + chrodrimanin H + O2 => chrodrimanin E + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75313", "l": "D-serine(out) + L-alanine(in) + Na(+)(in) => D-serine(in) + L-alanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.115", "l": "\"3-oxocholoyl-CoA 4-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18836", "l": "4-formylbenzenesulfonate + H2O + NAD(+) <=> 4-sulfobenzoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24306", "l": "(R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 => (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482772", "l": "Release of platelet cytosolic components (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.202", "l": "\"endo-chitodextinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805103", "l": "AURKA phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44291", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71841", "l": "dehydroepiandrosterone 3-sulfate(in) => dehydroepiandrosterone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41264", "l": "NAD(+) + prostaglandin A1 => 15-oxo-prostaglandin A1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.26", "l": "\"intermediate cleaving peptidase 55\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047660", "l": "amidinoaspartase activity", "d": ["Catalysis of the reaction: N-amidino-L-aspartate + H2O = L-aspartate + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47684", "l": "[(1->2)-beta-D-glucosyl](n) + phosphate = [(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}, {"i": "EC:2.4.1.333", "l": "\"1,2-beta-oligoglucan phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40610", "l": "1-tetradecanoyl-sn-glycerol + H2O <=> glycerol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60081", "l": "4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48414", "l": "globoside Gb4Cer + N-acetyl-alpha-D-galactosamine => globoside IV3GalNAc-Gb4Cer + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:1901567", "l": "fatty acid derivative binding", "d": ["Binding to fatty acid derivative."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047186", "l": "N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity", "d": ["Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-7-O(or 9-O)-acetylneuraminate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32859", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71686", "l": "2 H(+)(out) + L-aspartyl-glycine(out) <=> 2 H(+)(in) + L-aspartyl-glycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17576", "l": "demethylmacrocin + S-adenosyl-L-methionine <=> H(+) + macrocin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004595", "l": "pantetheine-phosphate adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35015", "l": "riboflavin(in) = riboflavin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30491", "l": "L-valine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794523", "l": "SLC22A1 transports Cipro into renal cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66848", "l": "2 Cu(2+) + NADH = 2 Cu(+) + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46169", "l": "ATP + CoA + pentanoate => AMP + diphosphate + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58573", "l": "O-acetyl-15alpha-stemmadenine + O2 => H2O2 + precondylocarpine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38321", "l": "(3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate => chorismate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004427", "l": "inorganic diphosphate phosphatase activity", "d": ["Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-901047", "l": "Binding of ERp57 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204873", "l": "Interaction of Tie2 and Shp2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51097", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44806", "l": "2-demethylmenaquinol-9 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60351", "l": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15232", "l": "alpha-D-mannose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63121", "l": "(11Z)-eicosenamide + H2O => (11Z)-eicosenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26439", "l": "3-hydroxypropanoate + NADP(+) => 3-oxopropanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109639", "l": "Formation of the closed pre-initiation complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54761", "l": "ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide => 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388809", "l": "CTLA-4 binds B7-1/B7-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16324", "l": "(S)-indan-1-ol + NADP(+) <=> H(+) + indan-1-one + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33366", "l": "D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-mannitol 1-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672951", "l": "Inactive RAFs bind YWHAB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83650", "l": "FasL:Fas binds FADD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29845", "l": "ADP + phosphate + propanoyl-CoA => ATP + CoA + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855232", "l": "RELN:VLDLR binds DAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004550", "l": "nucleoside diphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16000", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADH + O2 <=> 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22739", "l": "5-formimidoyltetrahydrofolate + 2 H(+) <=> 5,10-methenyltetrahydrofolate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28862", "l": "Ag(+)(in) + H(+)(in) <=> Ag(+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66285", "l": "tomatidine + UDP-alpha-D-glucose => H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36212", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1467466", "l": "ABCA4 mediates atRAL transport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909721", "l": "Translocation of ISGF3 complex to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020504", "l": "MECP2 binds GRIN2B gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419334", "l": "Melatonin receptors can bind melatonin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44458", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6810076", "l": "DDO oxidizes D-Asp to OA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684071", "l": "RNF4 ubiquitinates MDC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65877", "l": "5alpha-androst-1-ene-3,17-dione + H2O => 1-hydroxy-5alpha-androstan-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619756", "l": "NR1H2 binds ABCA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693243", "l": "RHOD translocates to the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36671", "l": "(17Z)-hexacosenoyl-CoA + sphinganine = CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004151", "l": "dihydroorotase activity", "d": ["Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9633044", "l": "ESR binds STRN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51695", "l": "prephenate + S-adenosyl-L-methionine <=> 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004056", "l": "argininosuccinate lyase activity", "d": ["Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3700984", "l": "TP53 family members stimulate BAX transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8863727", "l": "STON2 is neddylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047116", "l": "1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate = NADH + CO2 + catechol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451900", "l": "IL2RB binds JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851933", "l": "MET phosphorylates GAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67685", "l": "a long-chain fatty acid(in) + ATP + H2O => a long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52160", "l": "(E)-phenylacetaldehyde oxime = (Z)-phenylacetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928639", "l": "p-EFNB binds GRB4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1888198", "l": "FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38184", "l": "19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] => 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43099", "l": "guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047861", "l": "diiodotyrosine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60717", "l": "(1R,3R)-chrysanthemal + H2O + NADP(+) => (1R,3R)-chrysanthemate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15299", "l": "3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446322", "l": "PARVA associates with Paxillin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692236", "l": "DMRT1 binds the FOXL2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39811", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855648", "l": "SALM3 binds LAR-RPTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706350", "l": "FLT3 phosphorylates CBL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25098", "l": "ATP + UDP = ADP + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21515", "l": "3,6-anhydro-L-galactonate <=> 2-dehydro-3-deoxy-L-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37967", "l": "galactitol + NADP(+) = D-galactose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46259", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120091", "l": "jasmonic acid hydrolase", "d": ["Catalyzes the hydroxylation of jasmonic acid to 12OH-jasmonic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23081", "l": "L-rhamnonate => 2-dehydro-3-deoxy-L-rhamnonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853792", "l": "RET tyrosine phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769397", "l": "SOST binds LRP5/6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46968", "l": "A + dihydroisopentenyldehydrorhodopin = AH2 + isopentenyldehydrorhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168400", "l": "iE-DAP elicits a NOD1 response (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40935", "l": "a 1-acylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451418", "l": "Pellino ubiquitinates IRAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42426", "l": "(2R,3S)-3-methylmalate => 2-methylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29258", "l": "Ca(2+)(in) + Na(+)(out) <=> Ca(2+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139909", "l": "Translocation of BMF to mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37259", "l": "(2S)-2-aminobutanoate + H2O + NAD(+) = 2-oxobutanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27728", "l": "2-hydroxy-3-oxopropanoate + pyruvate => 5-dehydro-4-deoxy-D-glucarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163310", "l": "TFAM binds to mitochondrial promoters (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29755", "l": "(R)-lipoate(in) = (R)-lipoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36976", "l": "AMP + phosphate => adenine + alpha-D-ribose 1,5-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44300", "l": "2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA = 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692755", "l": "CDK1 phosphorylates MAPK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16736", "l": "H(+) + orsellinate <=> CO2 + orcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950213", "l": "Expression of Phosphatidylinositol transfer protein alpha isoform (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849085", "l": "ARHGAP35 binds RHOA:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65722", "l": "butanal + CO2 + H(+) + succinate + sulfate => 2-oxoglutarate + butyl sulfate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18904", "l": "H(+) + H2O + N-benzyloxycarbonyl-L-leucine <=> benzyl alcohol + CO2 + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60170", "l": "a fatty acyl monophosphate + ADP => a fatty acid + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797803", "l": "PTPRD binds SLITRK1-6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008886", "l": "glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H2O + NADP+ = 3-phospho-D-glycerate + 2 H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20835", "l": "ATP + guanine(out) + H2O <=> ADP + guanine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112396", "l": "Separation of elongating transcript from template (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0004301", "l": "epoxide hydrolase activity", "d": ["Catalysis of the reaction: an epoxide + H2O = a glycol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295622", "l": "SPRY2 binds CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400204", "l": "PPARA binds RXRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41094", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204863", "l": "Interaction of Tie2 with Ang2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707586", "l": "FeHM oxidises LDL,HDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047066", "l": "phospholipid-hydroperoxide glutathione peroxidase activity", "d": ["Catalysis of the reaction: a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75227", "l": "H2O + L-xylono-1,4-lactone = H(+) + L-xylonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12617", "l": "ATP + N-acetyl-alpha-D-galactosamine = ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": []}, {"i": "EC:2.7.1.157", "l": "\"N-acetylgalactosamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70160", "l": "folate(in) + H(+)(in) => folate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51076", "l": "2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate = 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18946", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624120", "l": "CEBPA binds CDK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21862", "l": "adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate => 3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14584", "l": "H(+) + 2 monodehydro-L-ascorbate radical + NADH <=> 2 L-ascorbate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112396", "l": "Separation of elongating transcript from template (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61171", "l": "quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.63", "l": "\"beta-carotene 4-ketolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53191", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O <=> 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48803", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.003741351937961", "identifiers": [{"i": "GO:0019838", "l": "growth factor binding", "d": ["Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15458", "l": "cis-1,2-dihydrobenzene-1,2-diol + NAD(+) => catechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12313", "l": "dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 => 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68136", "l": "acetophenone + H(+) + NADPH = (R)-1-phenylethanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445079", "l": "Phosphorylation of L1 by ERK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.6", "l": "\"ribonuclease IV\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50011", "l": "6-methylpretetramide + 2 H(+) + NADPH + O2 <=> 4-hydroxy-6-methylpretetramide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809521", "l": "BPIF binds bacteria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53956", "l": "gamma-L-glutamyl-[BtrI ACP] + H(+) = 4-aminobutanoyl-[BtrI ACP] + CO2", "d": []}, {"i": "EC:4.1.1.95", "l": "\"L-glutamyl-[BtrI acyl-carrier protein] decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14904", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> casbene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45363", "l": "H2O + N-(11Z-eicosenoyl)-sphinganine <=> (11Z)-eicosenoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626816", "l": "PIN1 binds p-S345-NCF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.098124162625822", "identifiers": [{"i": "GO:0001727", "l": "lipid kinase activity", "d": ["Catalysis of the phosphorylation of a simple or complex lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-933533", "l": "Dimerization of p-IRF7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44764", "l": "2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705584", "l": "HMGCR dimer binds statins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198508", "l": "MDH1 oxidizes MAL to OA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018538", "l": "epoxide carboxylase activity", "d": ["Catalysis of the generic reaction: epoxide + CO2 + NAD+ + electron donor = beta-keto acid + NADH + reduced electron donor; the electron donor may be NADPH or a dithiol. This reaction is the ring opening and carboxylation of an epoxide; for example: epoxypropane + CO2 + NAD+ + NADPH = acetoacetate + NADH + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72892", "l": "acetylcholine(out) + 2 H(+)(in) => acetylcholine(in) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65001", "l": "holo-[ACP] + octanoyl-AMP => AMP + H(+) + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607746", "l": "PKC-delta is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210805", "l": "Removal of miRNA passenger strand (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001084", "l": "L-arabinofuranose binding", "d": ["Binding to L-arabinofuranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690669", "l": "CD22 binds itself to form homo-oligomers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4167511", "l": "HLCS biotinylates ACACB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655832", "l": "Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862184", "l": "USP48 cleaves polyubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018515", "l": "pimeloyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + pimelyl-CoA = 2,3-didehydropimeloyl-CoA + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390425", "l": "FAR1 reduces PalmCoA to HXOL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110307", "l": "REV1 binds AP-dsDNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10879", "l": "4-hydroxybenzoate + H(+) <=> CO2 + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43435", "l": "butan-1-ol + 2 Fe(III)-[cytochrome c] <=> butanal + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.706056554619465", "identifiers": [{"i": "GO:0008484", "l": "sulfuric ester hydrolase activity", "d": ["Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50857", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426489", "l": "RISC binds inexactly matching target RNAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69993", "l": "(22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + NADPH => 3-dehydro-6-deoxoteasterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54879", "l": "(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> (3S)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254291", "l": "ERBB4s80 binds STAT5A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35066", "l": "H2O + pyrazinamide <=> NH4(+) + pyrazine-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043890", "l": "N-acetylgalactosamine-6-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004791", "l": "thioredoxin-disulfide reductase (NADP) activity", "d": ["Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296045", "l": "Activation of Potassium transport channels (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420724", "l": "CASR binds Ca2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50462", "l": "a medium-chain fatty acyl-[ACP] + AMP + diphosphate => a medium chain fatty acid + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32792", "l": "L-ectoine(in) => L-ectoine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31181", "l": "3-oxododecanoyl-CoA + H(+) + NADH => (3S)-3-hydroxydodecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018808", "l": "RAC3 binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29352", "l": "Zn(2+)(in) => Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874192", "l": "MBTPS2 (S2P) cleaves CREB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655268", "l": "Activated FGFR2 mutants phosphorylate FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655295", "l": "Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23838", "l": "4-methylsulfanyl-2-oxobutanoate + L-alanine => D-methionine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928620", "l": "PAK1 autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2514865", "l": "cGMP dissociates from CNG channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62114", "l": "H2O + iminosuccinate => (3S)-3-hydroxy-D-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54552", "l": "1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33518", "l": "2 5,6-dihydroxyindole + O2 <=> 2 H2O + 2 indole-5,6-quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1253343", "l": "WWOX binds ERBB4s80 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15486", "l": "(2R,3S)-homoisocitrate => cis-homoaconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61379", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O <=> 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730904", "l": "Auto-ubiquitination of TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879907", "l": "Tyrosine kinases phosphorylate the receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22119", "l": "luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0120108", "l": "DNA-3'-diphospho-5'-guanosine diphosphatase", "d": ["Catalysis of the reaction: (DNA)-3'-diphospho-5'-guanosine + H2O = (DNA)-3'-phosphate + GMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60910", "l": "an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68321", "l": "1D-myo-inositol 2,4,5-triphosphate + H2O => 1D-myo-inositol 2,5-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683734", "l": "Glycosylated M localizes to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54679", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (+)-kolavenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19984", "l": "NADP(+) + S-(hydroxymethyl)glutathione <=> H(+) + NADPH + S-formylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69227", "l": "a (Z)-alkenyl glucosinolate + H2O <=> a (Z)-N-(sulfonatooxy)alkenimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47481", "l": "deoxycholate + NADP(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17123", "l": "H(+) + L-homocitrulline + phosphate => carbamoyl phosphate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377640", "l": "Autophosphorylation of SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49305", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050078", "l": "malonate CoA-transferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34518", "l": "tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine <=> N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003832", "l": "beta-alanyl-dopamine hydrolase activity", "d": ["Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051736", "l": "ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA."]}, {"i": "RHEA:54580", "l": "a 5'-end dephospho-ribonucleoside-RNA + ATP = a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42799", "l": "(9Z,12Z)-octadecadienoyl-CoA + cholesterol <=> cholesteryl (9Z,12Z)-octadecadienoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25104", "l": "ATP + pyridoxamine = ADP + H(+) + pyridoxamine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70398", "l": "3-oxosphinganine + docosanoyl-CoA <=> CoA + H(+) + N-docosanoyl-3-ketodihydrosphingosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40687", "l": "1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol = 1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858475", "l": "TNFSF9 binds TNFRSF9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388817", "l": "ICOS binds ICOSL/B7-H2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70351", "l": "beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O = beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418200", "l": "SRC-1 bound to ARRB2 is not activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16315", "l": "5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+) => 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875661", "l": "GGA3 associates with activated MET receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610752", "l": "GLI3R translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199144", "l": "Nectin 2 binds CD226 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44106", "l": "decanoate + 2 H(+) + NADH => decanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29605", "l": "4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64609", "l": "L-threonyl-[protein] + UTP => diphosphate + uridylyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32357", "l": "2 H(+) + ternatin C5 + 2 UDP => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5668545", "l": "NIK autophosphorylates on T559 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5444516", "l": "Formation of MSH2:MSH6 Complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62468", "l": "3,4-dihydroxybenzoate + ATP + H(+) = 3,4-dihydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429101", "l": "HMIT co-transports myo-inositol with a proton (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444647", "l": "C3a receptor binds anaphylatoxin C3a (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20568", "l": "(2E)-geranyl diphosphate + H2O <=> (1S,2S,4R)-endo-fenchol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-481007", "l": "Exocytosis of platelet alpha granule contents (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69683", "l": "daidzein 7-O-beta-D-glucoside + H2O = beta-D-glucose + daidzein + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74223", "l": "H2O + L-seryl-tRNA(Ala) = L-serine + tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66215", "l": "asc-omegaC5-CoA + O2 <=> asc-omegaDeltaC5-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62787", "l": "2 fonsecin B + H(+) + NADPH + O2 <=> bifonsecin B + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37239", "l": "2',3'-cyclophospho-UMP + H2O = H(+) + uridine 2'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5618107", "l": "ATP binding to HSP90 triggers conformation change (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445079", "l": "Phosphorylation of L1 by ERK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35022", "l": "L-threonine(in) <=> L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.21", "l": "\"maltose epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46504", "l": "dodecanoyl-AMP + holo-[ACP] = AMP + dodecanoyl-[ACP] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166792", "l": "Conversion of C2 into C2a and C2b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051379", "l": "epinephrine binding", "d": ["Binding to epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58439", "l": "4-methylpentan-1-ol + NADP(+) <=> 4-methylpentanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73694", "l": "3'-AMP(out) + phosphate(in) <=> 3'-AMP(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74723", "l": "isorhamnetin + S-adenosyl-L-methionine = 3',4'-O-dimethylquercetin + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6793666", "l": "MDM2 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70161", "l": "folate(out) + H(+)(out) => folate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11098", "l": "dihydroxyacetone phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114671", "l": "vWF binds to collagen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12841", "l": "pyridoxamine + pyruvate = L-alanine + pyridoxal", "d": []}, {"i": "EC:2.6.1.30", "l": "\"pyridoxamine--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035299", "l": "inositol pentakisphosphate 2-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806610", "l": "Keratin filament formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046988", "l": "asioloorosomucoid beta-1,3-glucuronosyltransferase activity", "d": ["Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11794", "l": "1,2-epoxypropane + H2O + NAD(+) => H(+) + NADH + O2 + propene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0016624", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide."]}, {"i": "EC:1.2.4.-", "l": "\"With a disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878117", "l": "RUNX3 binds ZFHX3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938887", "l": "PML binds RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57711", "l": "(E)-coniferaldehyde + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-4-trans-coniferyl aldehyde + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229283", "l": "LCNs bind lipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952371", "l": "MDM2 binds RUNX3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671993", "l": "CIT-3 binds DLG4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47371", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose <=> a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.55", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16747", "l": "2,3-epoxyphylloquinone + A + H2O => AH2 + O2 + phylloquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32373", "l": "all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate => all-trans-violaxanthin + 2 L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61967", "l": "a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41149", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36086", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203973", "l": "Vesicle budding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60984", "l": "16-hydroxyhexadecanoate + NAD(+) = 16-oxohexadecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26517", "l": "cyclohexan-1,2-dione + H2O <=> 6-oxohexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15009", "l": "(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH", "d": []}, {"i": "EC:1.5.1.3", "l": "\"dihydrofolate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13831", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-alpha-D-rhamnose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031703", "l": "type 2 angiotensin receptor binding", "d": ["Binding to a type 2 angiotensin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420975", "l": "Ca impermeable AMPA receptor ligand binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903264", "l": "nitrate reductase activity involved in anaerobic electron transport chain", "d": ["Any nitrate reductase activity that is involved in anaerobic electron transport chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30586", "l": "2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide <=> 2-demethylmenaquinone-8 + H2O + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75642", "l": "(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate <=> (12S,13R)-epoxy-(10R)-hydroxy-(8E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15684", "l": "2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) <=> (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008675", "l": "2-dehydro-3-deoxy-phosphogluconate aldolase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0070008", "l": "serine-type exopeptidase activity", "d": ["Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18500", "l": "L-ribulose 5-phosphate <=> L-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40844", "l": "FAD + H(+) + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202947", "l": "Caspase mediated cleavage of APC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295622", "l": "SPRY2 binds CBL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19397", "l": "(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": []}, {"i": "EC:6.3.2.5", "l": "\"phosphopantothenate--cysteine ligase (CTP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626817", "l": "PKC phosphorylates NCF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62920", "l": "1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol = 1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45342", "l": "(9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+) => [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203977", "l": "SAR1 Activation And Membrane Binding (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16975", "l": "2,5-dihydroxypyridine + A + H2O => 2-hydroxypyridine + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2769007", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.4", "l": "\"dipeptidyl-peptidase III\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37822", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53921", "l": "ATP + L-threonyl-[Fas-activated protein] => ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012654", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30609", "l": "AH2 + all-trans-zeta-carotene => A + all-trans-phytofluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33225", "l": "CO2 + NADH + propanoyl-CoA => 2-oxobutanoate + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53932", "l": "O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24060", "l": "N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19315", "l": "an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48342", "l": "a medium-chain fatty acyl-CoA + AMP + diphosphate => a medium chain fatty acid + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30407", "l": "hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] = oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.97.1.12", "l": "\"photosystem I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791349", "l": "Defective EPM2A does not dephosphorylate phosphoglycogen (type 2A disease) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-434989", "l": "SEMA7A binds to PLXNC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44369", "l": "Cr(6+) + 2 NADPH + O2 => Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008973", "l": "phosphopentomutase activity", "d": ["Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65696", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031885", "l": "type 1 member 2 taste receptor binding", "d": ["Binding to a type 1 member 2 taste receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0035381", "l": "ATP-gated ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57759", "l": "2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66322", "l": "2',3'-cGAMP(in) => 2',3'-cGAMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58350", "l": "2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate => 2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42578", "l": "2-methylpropanoate + 2-oxopent-4-enoate + H(+) => 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33222", "l": "ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73079", "l": "S-adenosyl-L-methionine + scutellarein = S-adenosyl-L-homocysteine + scutellarein 7-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429415", "l": "SYK binds to integrin alphaIIb beta3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34631", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]", "d": []}, {"i": "EC:1.14.15.15", "l": "\"cholestanetriol 26-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618725", "l": "SOX10, EGR2 and NAB proteins bind the GJB1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862084", "l": "PILRA,PILRB bind CD99 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956365", "l": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876446", "l": "p-ULK1 phosphorylates DENND3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18903", "l": "benzyl alcohol + CO2 + L-leucine => H(+) + H2O + N-benzyloxycarbonyl-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432143", "l": "PECAM-1 binds PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34765", "l": "(S,S)-tartrate(in) + succinate(out) => (S,S)-tartrate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0043175", "l": "RNA polymerase core enzyme binding", "d": ["Binding to an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389862", "l": "Conversion of glyoxylate to oxalate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380780", "l": "Activation of Src (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20782", "l": "ADP + GDP => ATP + GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46419", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794444", "l": "ALB binds Cipro (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-217255", "l": "FMO1:FAD N-oxidises TAM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34590", "l": "2-oxoglutarate + O2 + pentalenolactone E <=> CO2 + pentalenolactone F + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58405", "l": "hexan-1-ol + NADP(+) => H(+) + hexanal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73395", "l": "L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432121", "l": "LDL binds to LRP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.21", "l": "\"thymidine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75244", "l": "FASL binds FAS Receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65763", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 17alpha-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662466", "l": "XYLB phosphorylates D-xylulose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30069", "l": "glycine betaine + 2 H(+) + NADPH => betaine aldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.6", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0004629", "l": "phospholipase C activity", "d": ["Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008177", "l": "RUNX2 binds HEY1,HEY2,HES1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54675", "l": "(+)-kolavenyl diphosphate + H2O <=> (+)-kolavelool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55083", "l": "ADP-alpha-D-glucose + D-fructose <=> ADP + H(+) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952996", "l": "E2F7 forms homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70764", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44490", "l": "3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16958", "l": "3',5'-cyclic GMP + H2O => GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53193", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O => 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58887", "l": "AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 <=> A + chloramphenicol + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47945", "l": "(2E)-geranyl diphosphate + H2O => (2E)-geranyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0017128", "l": "phospholipid scramblase activity", "d": ["Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201457", "l": "BMP2 binds to the receptor complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382058", "l": "Nck binds to the active PDGF receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74327", "l": "O-propanoyl-(R)-carnitine(in) = O-propanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72520", "l": "2 H(+) + NADH + O2 + phenazine-1,6-dicarboxylate => 6-hydroxyphenazine-1-carboxylate + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004633", "l": "phosphopantothenoylcysteine decarboxylase activity", "d": ["Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H+ = CO2 + pantetheine 4'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390425", "l": "FAR1 reduces PalmCoA to HXOL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174119", "l": "Free APC/C phosphorylated by Plk1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60744", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone = CoA + pyrethrin I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48483", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose <=> 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2514831", "l": "Fibrillin-1 degradation by MMP14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52632", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP", "d": []}, {"i": "EC:2.7.2.19", "l": "\"[amino-group carrier protein]-L-glutamate 6-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14395", "l": "3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine => N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047120", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+ = 3,4-dihydroxybenzoate + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56972", "l": "(R)-3-hydroxy-2-methylpropanoate + NAD(+) = (R)-methylmalonate semialdehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39674", "l": "(9Z)-hexadecenoyl-CoA + AH2 + O2 <=> (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9706393", "l": "RHOBTB3 binds ATP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59958", "l": "a nitrile + sulfate + sulfur => a (Z)-N-(sulfonatooxy)alkanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20884", "l": "H2O + L-serine + NAD(+) = 3-hydroxypyruvate + H(+) + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.7", "l": "\"serine 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29953", "l": "H(+)(out) + uridine(out) => H(+)(in) + uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21823", "l": "L-homocysteine + S-adenosyl-L-methionine <=> H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855189", "l": "I(1,4,5,6)P4 transports from the ER lumen to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5622129", "l": "FABP5 binds atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68615", "l": "Formation of ORC(1-6) complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20447", "l": "L-aspartate + prephenate => L-arogenate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68729", "l": "26-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxy-lanosta-8, 24-dien-26-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65736", "l": "2-oxoglutarate + O2 + octyl sulfate = CO2 + H(+) + octanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21658", "l": "CDP-3,6-dideoxy-alpha-D-mannose => CDP-alpha-D-paratose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29893", "l": "ADP + H(+) + L-histidine(in) + phosphate => ATP + H2O + L-histidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019155", "l": "3-(imidazol-5-yl)lactate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32184", "l": "cholesterol + O2 => cholest-5-en-3-one + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54819", "l": "L-glutaminyl-[protein] + L-lysyl-[protein] <=> [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28995", "l": "H(+)(out) + L-threonine(in) = H(+)(in) + L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449803", "l": "IL10 dimer binds IL10RA:JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50702", "l": "calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75874", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016166", "l": "phytoene dehydrogenase activity", "d": ["Catalysis of the dehydrogenation of phytoene to produce a carotenoid intermediate such as phytofluene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38140", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983153", "l": "E1 mediated ubiquitin activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72367", "l": "estrone 3-sulfate(out) + succinate(in) = estrone 3-sulfate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67328", "l": "(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione = trichosetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874849", "l": "CREBRF binds CREB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35128", "l": "L-alanyl-D-glutamate(out) => L-alanyl-D-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24304", "l": "(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2", "d": []}, {"i": "EC:1.4.4.2", "l": "\"glycine dehydrogenase (aminomethyl-transferring)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797974", "l": "LRRTMs bind NRXNs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018484", "l": "4-hydroxybenzaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848774", "l": "PTK6 binds DOK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53629", "l": "(2E,6E)-farnesyl diphosphate => (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22114", "l": "3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+) => isoxazolin-5-one + O-acetyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56679", "l": "dihydroferuloyl-CoA + NADP(+) <=> (E)-feruloyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807106", "l": "PTEN undergoes monoubiquitination (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68131", "l": "a fatty acyl-CoA + phytol <=> a fatty acid phytyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668831", "l": "CST complex formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008607", "l": "phosphorylase kinase regulator activity", "d": ["Modulation of the activity of the enzyme phosphorylase kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192061", "l": "CYP46A1 24-hydroxylates CHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38895", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20320", "l": "L-proline + NADP(+) <=> 1-pyrroline-2-carboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676229", "l": "WIPIs bind PI3P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39400", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA => (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50382", "l": "1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA => 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16592", "l": "A + sucrose <=> 3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10483", "l": "2-oxoglutarate + 4-hydroxy-L-glutamate <=> 4-hydroxy-2-oxoglutarate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047792", "l": "cyanohydrin beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + (S)-4-hydroxymandelonitrile = UDP + (S)-4-hydroxy-mandelonitrile beta-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41558", "l": "(3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050162", "l": "oxalate oxidase activity", "d": ["Catalysis of the reaction: 2 H+ + O2 + oxalate = 2 CO2 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67474", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine => H2O + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62431", "l": "3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA <=> 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71513", "l": "phylloquinone(in) => phylloquinone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050051", "l": "leukotriene-B4 20-monooxygenase activity", "d": ["Catalysis of the reaction: leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H+ + H2O + oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102189", "l": "4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) + H+ <=> 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351208", "l": "Spermidine  => N-acetylated spermidine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60462", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070674", "l": "hypoxanthine dehydrogenase activity", "d": ["Catalysis of the reaction: hypoxanthine + NAD+ + H2O = xanthine + NADH + H+."]}, {"i": "REACT:R-HSA-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654533", "l": "KRAS4B recycles to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0072533", "l": "tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity", "d": ["Catalysis of the meta-hydroxylation of any of the three phenolic rings on tricoumaroyl spermidine or any of its mono- or dicaffeoyl spermidine derivatives."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322429", "l": "XIAP monoubiquinates TLE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761170", "l": "Expression of PAX2 in intermediate mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10263", "l": "ATP + H2O + Mg(2+)(out) <=> ADP + H(+) + Mg(2+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63399", "l": "A + Fe(II)-heme i + H2O <=> AH2 + Fe(II)-hydroxyheme i", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018845", "l": "2-hydroxychromene-2-carboxylate isomerase activity", "d": ["Catalysis of the reaction: 2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate. (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate is also known as trans-o-hydroxybenzylidenepyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56761", "l": "24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61512", "l": "malvidin + UDP-alpha-D-glucose = malvidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17268", "l": "trans-aconitate <=> cis-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130349", "l": "Generation of CLIP from lip10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12232", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) = [thioredoxin]-dithiol + glycine + H(+) + phosphate", "d": []}, {"i": "EC:1.21.4.2", "l": "\"glycine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61974", "l": "1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65642", "l": "CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine => (4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46356", "l": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047561", "l": "3-hydroxyanthranilate oxidase activity", "d": ["Catalysis of the reaction: 3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9702818", "l": "CALCR binds erenumab (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19229", "l": "AMP + an aromatic aldehyde + diphosphate + NADP(+) = an aromatic carboxylate + ATP + H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.30", "l": "\"carboxylate reductase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16753", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 = 3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610735", "l": "NUMB binds ITCH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5660666", "l": "CBP and p300 binds NF-kB complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28638", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-5-epi-aristolochene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052798", "l": "beta-galactoside alpha-2,3-sialyltransferase activity", "d": ["Catalysis of the transfer of sialyl residues alpha-2,3-linked to a beta galactosyl residue on the donor to form an alpha-2,3 linkage to a terminal beta galactosyl residue on the acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451900", "l": "IL2RB binds JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30924", "l": "(R)-glycerate + ADP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052771", "l": "coenzyme F390-G hydrolase activity", "d": ["Catalysis of the reaction: coenzyme F390-G = GMP + coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50164", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000310", "l": "AURKA phosphorylates PLK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54087", "l": "7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine <=> archaeosine(15) in tRNA + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38827", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43584", "l": "H2O + iminoarginine = 5-guanidino-2-oxopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30332", "l": "all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426209", "l": "DAG activation of TRPC channels (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41668", "l": "dihydrochelirubine + NADP(+) = chelirubine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0050463", "l": "nitrate reductase [NAD(P)H] activity", "d": ["Catalysis of the reaction: nitrite + NAD(P)+ + H2O = nitrate + NAD(P)H + H+."]}, {"i": "EC:1.7.1.2", "l": "\"nitrate reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48388", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013157", "l": "CDC42 binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70145", "l": "28-nortyphasterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691150", "l": "TFR2 dimer binds 2xholoTF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19213", "l": "acetyl-CoA + an S-substituted L-cysteine = an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.80", "l": "\"cysteine-S-conjugate N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59261", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15080", "l": "H(+) + N-[(R)-pantothenoyl]-L-cysteine <=> (R)-pantetheine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421158", "l": "xanthine + H2O + NAD+ => urate + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016621", "l": "cinnamoyl-CoA reductase activity", "d": ["Catalysis of the reaction: cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34984", "l": "sulfate(in) => sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047319", "l": "aspartate-phenylpyruvate transaminase activity", "d": ["Catalysis of the reaction: keto-phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636251", "l": "PPE2 binds KPNA1:KPNB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8953013", "l": "E2F7 binds E2F8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74841", "l": "UDP(out) + UDP-alpha-D-glucuronate(in) => UDP(in) + UDP-alpha-D-glucuronate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444859", "l": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674385", "l": "p-T,Y MAPKs dimerize (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035925", "l": "mRNA 3'-UTR AU-rich region binding", "d": ["Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53830", "l": "a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate => 2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878054", "l": "HIPK2 phosphorylates RUNX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46884", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641147", "l": "DACT1 binds DVL2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32907", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51877", "l": "2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate => desmethylxanthohumol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730886", "l": "Phosphorylation of SHC by SYK kinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390673", "l": "CHRM2,4 bind acetylcholine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75033", "l": "(9Z-octadecenoyl)-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 9-hydroxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806629", "l": "Formation of tonofilament bundles (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67329", "l": "(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione => trichosetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34006", "l": "5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 <=> 7-dehydrodesmosterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1467466", "l": "ABCA4 mediates atRAL transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61471", "l": "a cytidine in tRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69420", "l": "H2O2 + iodide = H2O + hypoiodite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23732", "l": "(R)-5-diphosphomevalonate + ATP = ADP + CO2 + isopentenyl diphosphate + phosphate", "d": []}, {"i": "EC:4.1.1.33", "l": "\"diphosphomevalonate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75601", "l": "ectocarpin A + H2O => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44334", "l": "ADP + bacilysin + H(+) + phosphate => ATP + L-alanine + L-anticapsin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994000", "l": "Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45069", "l": "(R)-carnitine + an acyl-CoA => CoA + O-acyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212642", "l": "L-Glutamine transport into neurons (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33732", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67112", "l": "L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62201", "l": "ethanol + 2 Fe(III)-[cytochrome c] => acetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49412", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose = alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.341", "l": "\"alpha-1,2-colitosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36403", "l": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73665", "l": "CoA + H(+) + piperyline => (E,E)-piperoyl-CoA + pyrrolidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72656", "l": "1-hydroxy-6-methoxyphenazine + NADPH + O2 => 1-hydroxy-6-methoxyphenazine N(10)-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36230", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65931", "l": "3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine <=> 3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592247", "l": "Expression of ATP5B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050017", "l": "L-3-cyanoalanine synthase activity", "d": ["Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62218", "l": "H(+) + NADPH + phyllostine => isoepoxydon + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38072", "l": "2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28301", "l": "(2E,6E)-farnesyl diphosphate <=> (E)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19867", "l": "4 CO2 + coproporphyrinogen III => 4 H(+) + uroporphyrinogen III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734475", "l": "PPARA binds fibrates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5625426", "l": "Retrograde IFT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786421", "l": "CHIA hydrolyses chitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013284", "l": "NOTCH3-ligand complex is cleaved to produce NEXT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953111", "l": "E2F6 binds TFDP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35146", "l": "benzoyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46484", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018729", "l": "propionate CoA-transferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0005416", "l": "amino acid:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1362416", "l": "Frataxin binds iron (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114684", "l": "Phosphorylation of Syntaxin-4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26468", "l": "a menaquinone + H(+) + S-adenosyl-L-homocysteine => a 2-demethylmenaquinone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160072", "l": "ubiquitin ligase complex scaffold activity", "d": ["The binding activity of a molecule that brings together an ubiquitin ligase and an ubiquitin ligase-substrate adaptor, permitting those molecules to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013438", "l": "RHOD binds effectors at the endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52382", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69253", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate => 2-(thiiran-2-yl)acetonitrile + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9698844", "l": "MLKL binds HSP90:CDC37 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67770", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0034594", "l": "phosphatidylinositol trisphosphate phosphatase activity", "d": ["Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141159", "l": "TNF-mediated dimerization of procaspase-8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28840", "l": "H(+)(out) + Zn(2+)(in) => H(+)(in) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938121", "l": "SERPINB13 binds CTSK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53075", "l": "2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58592", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14886", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] => ADP-D-ribose + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654569", "l": "Activated FGFR1 binds FRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801195", "l": "STEAP3 binds BNIP3L (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71712", "l": "H(+)(out) + L-tyrosylglycine(out) => H(+)(in) + L-tyrosylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64135", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48623", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione <=> (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48484", "l": "a propanoate ester + H2O = an aliphatic alcohol + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614461", "l": "Tetramerization of procollagen VI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.2", "l": "\"DNA ligase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73708", "l": "ATP(in) + UDP(out) => ATP(out) + UDP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38490", "l": "1-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16291", "l": "(R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH => (1R,2S)-ephedrine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54362", "l": "3-methylbutanal + CO2 => 4-methyl-2-oxopentanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15511", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634228", "l": "TRAF1 is cleaved by caspases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64220", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10091", "l": "sucrose + UDP-alpha-D-galactose <=> 6(F)-alpha-D-galactosylsucrose + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68935", "l": "ATP + H(+) + NADPH + octanoate <=> AMP + diphosphate + NADP(+) + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71779", "l": "4-methyl-2-oxopentanoate(out) + H(+)(out) = 4-methyl-2-oxopentanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034583", "l": "21U-RNA binding", "d": ["Binding to a 21U-RNA, a 21-nucleotide RNA characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102910", "l": "dirigent protein activity", "d": ["Catalysis of the reaction: 2 H+ + 2 coniferol + O2 <=> (+)-pinoresinol + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70481", "l": "TPI1 isomerizes GA3P to DHAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23048", "l": "(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50608", "l": "leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10379", "l": "ATP + Cu(2+)(in) + H2O <=> ADP + Cu(2+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912413", "l": "NOTCH2 mRNA translation controlled by miRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4411402", "l": "Activation of NLK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102006", "l": "4-methyl-2-oxopentanoate dehydrogenase activity", "d": ["Catalysis of the reaction: 4-methyl-2-oxopentanoate + coenzyme A(4-) + NAD(1-) <=> isovaleryl-CoA(4-) + carbon dioxide + NADH(2-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64942", "l": "dGMP + H(+) + phosphate => dGDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052660", "l": "R-lactaldehyde reductase activity", "d": ["Catalysis of the reaction: (R)-propane-1,2-diol + NAD+ = (R)-lactaldehyde + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888577", "l": "Synthesis of GABA by GAD2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1364044", "l": "PRLR:JAK2 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199046", "l": "Ligands bind L-selectin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42990", "l": "cembrene C + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29643", "l": "D-maltoheptaose + H2O = alpha-D-glucose + D-maltohexaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37394", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69877", "l": "6alpha-hydroxycastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxocastasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34141", "l": "CO2 + Delta(9)-tetrahydrocannabinol => Delta(9)-tetrahydrocannabinolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071172", "l": "dihydromonapterin reductase activity", "d": ["Catalysis of the reaction: 7,8-dihydromonapterin + NADPH = tetrahydromonapterin + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52000", "l": "a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + glutathione = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43515", "l": "2-(dihydroxymethyl)-5-formylfuran + O2 <=> 2-carboxy-5-formylfuran + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.7.-", "l": "\"With a iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050297", "l": "stizolobate synthase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40407", "l": "1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48630", "l": "a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine => a ribonucleotide in rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-994148", "l": "LRRC16A binds F-actin capping protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68390", "l": "2 H2O + 2 indole-5,6-quinone-2-carboxylate => 2 5,6-dihydroxyindole-2-carboxylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31987", "l": "(S)-2,3-epoxysqualene = baruol", "d": []}, {"i": "EC:5.4.99.57", "l": "\"baruol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692764", "l": "MAPK6 binds CCND3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27710", "l": "ATP + guanosine = ADP + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14938", "l": "all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51946", "l": "2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine => 8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166542", "l": "beta-NGF dimer binds to TrkA receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.7", "l": "\"DNA ligase (ATP, ADP or GTP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45137", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate => 7,8-dihydroneopterin 3'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58494", "l": "ADP + Fe(III)-enterobactin(in) + H(+) + phosphate => ATP + Fe(III)-enterobactin(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043732", "l": "6-hydroxynicotinate dehydrogenase activity", "d": ["Catalysis of the reaction: 6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44075", "l": "1-O-alkyl-2-acyl-sn-glycerol + ATP <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617815", "l": "BBSome binds RAB3IP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67994", "l": "(Z)-1,2-dichloroethene + A + chloride + H(+) => AH2 + trichloroethene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2512800", "l": "SCARB1:ligand is endocytosed (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008397", "l": "sterol 12-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O."]}, {"i": "EC:1.14.14.139", "l": "\"5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016296", "l": "palmitoyl-[acyl-carrier-protein] hydrolase activity", "d": ["Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60724", "l": "dodecanal + H2O + NADP(+) = dodecanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50936", "l": "(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate = acetoacetyl-CoA + L-glutamate", "d": []}, {"i": "EC:2.6.1.111", "l": "\"3-aminobutanoyl-CoA transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684229", "l": "SUMO-p-N protein dimer binds genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65256", "l": "AH2 + O2 + verruculide C = A + H2O + verruculide C epoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33145", "l": "galactitol(out) => galactitol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953013", "l": "E2F7 binds E2F8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.19", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047068", "l": "N5,N10-methenyltetrahydromethanopterin hydrogenase activity", "d": ["Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2) = 5,10-methylenetetrahydromethanopterin + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55405", "l": "[phosphate](n) + UTP => [phosphate](n+1) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854408", "l": "APOBR dimer binds VLDLs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54015", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0004607", "l": "phosphatidylcholine-sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032781", "l": "WWTR1 (TAZ) binds TEAD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32285", "l": "H(+) + H2O + quinolinate => 3-hydroxyanthranilate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928631", "l": "GIT1 binds bPIX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24389", "l": "phosphate + uridine => alpha-D-ribose 1-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34173", "l": "(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O => L-aspartate 4-semialdehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24665", "l": "2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 => H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015151", "l": "alpha-glucoside transmembrane transporter activity", "d": ["Enables the transfer of alpha-glucosides from one side of a membrane to the other. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102157", "l": "(R)-sulfopropanediol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: (2R)-3-sulfopropanediol(1-) + NAD <=> 2-oxo-3-hydroxy-propane-1-sulfonate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3899291", "l": "SUMOylation of EP300 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56200", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose = H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33798", "l": "H2O + sucrose <=> alpha-D-glucose + beta-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69094", "l": "2 H(+) + NADH + pentanoate => H2O + NAD(+) + pentanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709098", "l": "DHFR dimer reduces FOLA to DHF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13699", "l": "ADP + D-ribose 5-phosphate + H(+) => ATP + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34770", "l": "5,10-methenyltetrahydrofolate + H2O <=> (6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69358", "l": "3-bromo-L-tyrosyl-[protein] + H2O => H(+) + hypobromite + L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851888", "l": "MET binds SHC1-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194678", "l": "CYP51A1 demethylates LNSOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10584", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)", "d": []}, {"i": "EC:2.3.1.170", "l": "\"6'-deoxychalcone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66176", "l": "ATP + H2O + taurochenodeoxycholate 3-sulfate(in) = ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9688838", "l": "RIPK3 binds STUB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31967", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.112", "l": "\"ent-cassa-12,15-diene 11-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009817", "l": "Acitretin binds to RAR:RXR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69174", "l": "(2E)-2-butenoate + L-lysyl-[protein] => H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618586", "l": "E2F1 binds the promoter of the MYC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110322", "l": "Formation of Pol zeta complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38479", "l": "N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine = H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42265", "l": "H(+) + malonyl-[ACP] + octanoyl-CoA => 3-oxodecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29532", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852552", "l": "MST1R autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649671", "l": "NEIL1 recognizes and binds FapyA-dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43912", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2089971", "l": "Secretion of collagens (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51191", "l": "nitric oxide + superoxide <=> peroxynitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40198", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33177", "l": "4-hydroxyphenylacetate(out) => 4-hydroxyphenylacetate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446322", "l": "PARVA associates with Paxillin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70720", "l": "L-alanine(in) => L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694492", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008706", "l": "6-phospho-beta-glucosidase activity", "d": ["Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43930", "l": "progesterone => pregn-5-ene-3,20-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27459", "l": "3,5-diiodo-L-tyrosine + H(+) + NADPH => 3-iodo-L-tyrosine + iodide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63316", "l": "(9Z,12Z)-octadecadienoate + O2 = 9-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392530", "l": "p-S400-Cot phosphorylates NIK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61596", "l": "[DsbD protein]-dithiol + [thioredoxin]-disulfide = [DsbD protein]-disulfide + [thioredoxin]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48572", "l": "3,5-dichlorocatechol + O2 = (2E,4E)-2,4-dichloromuconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70245", "l": "a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP => an N-acylsphing-4-enine + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110219", "l": "Cleavage of thymine by TDG glycosylase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27689", "l": "ATP + GDP <=> ADP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64710", "l": "butanal + H(+) + NADPH => butan-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43661", "l": "ATP + hydrogencarbonate + propanoyl-CoA => ADP + H(+) + methylmalonyl-CoA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102244", "l": "3-aminopropanal dehydrogenase activity", "d": ["Catalysis of the reaction: 3-ammoniopropanal + NAD + H2O <=> 2 H+ + beta-alanine + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263492", "l": "Defective HGSNAT does not acetylate Heparan chain(1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380272", "l": "Plk1-mediated phosphorylation of Nlp (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71747", "l": "2-oxoglutarate(out) + L-2-aminoadipate(in) = 2-oxoglutarate(in) + L-2-aminoadipate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42179", "l": "(9Z)-tetradecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-tetradecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47152", "l": "2,5-dioxopentanoate + H2O + NAD(+) = 2-oxoglutarate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45989", "l": "3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2 => 3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15204", "l": "6-hydroxymellein + S-adenosyl-L-methionine <=> 6-methoxymellein + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59106", "l": "a dolichyl phosphate + beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H(+) => a dolichyl beta-D-glucosyl phosphate + chenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57998", "l": "(20S)-ginsenoside Rh2 + H(+) + UDP => (20S)-protopanaxadiol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29284", "l": "L-alanine(in) + Na(+)(in) => L-alanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75367", "l": "cytidine(in) = cytidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202692", "l": "PIP3 binds to RhoA and activates it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013147", "l": "RAC1 GDIs block activation of RAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10886", "l": "acetaldehyde + desmosterol => (24R,24(1)R)-fucosterol epoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807585", "l": "BPI binds LPS on the bacterial surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981832", "l": "NMUR2 binds neuromedin-S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33300", "l": "[eIF5A protein]-L-lysine + spermidine => [eIF5A protein]-deoxyhypusine + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981443", "l": "CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30517", "l": "H(+) + S-methyl-5'-thioadenosine + thermospermine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31801", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+) => 4-amino-5-aminomethyl-2-methylpyrimidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033928", "l": "mannan 1,4-mannobiosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-mannosidic linkages in (1->4)-beta-D-mannans, to remove successive mannobiose residues from the non-reducing chain ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74237", "l": "L-threonine + tRNA(Ser) => H2O + L-threonyl-tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950771", "l": "Expression of SOD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0051087", "l": "protein-folding chaperone binding", "d": ["Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56353", "l": "4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 => 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005334", "l": "norepinephrine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) + Cl-(out) = norepinephrine(in) + Na+(in) + Cl-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110319", "l": "Elongation by POLH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13843", "l": "Fe(III)2-[transferrin] + NADH => Fe(II)2-[transferrin] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44118", "l": "CoA + eicosanyl hexadecanoate => eicosan-1-ol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445699", "l": "ATP Hydrolysis By Myosin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197770", "l": "STAB1 (FEEL-1) binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433454", "l": "Phosphorylation of GAB2 by SFKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665727", "l": "FMNL2 binds CDC42:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9035484", "l": "CysS248-MPST:TXN2 dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102606", "l": "octat-9-en-7-ol 5-monooxygenase activity", "d": ["Catalysis of the reaction: cyclooctat-9-en-7-ol + O2 + NADPH + H+ <=> cyclooctat-9-en-5,7-diol + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31076", "l": "(3S)-3-hydroxydodecanoyl-CoA => (2E)-dodecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47352", "l": "a hexanoate ester + H2O = an aliphatic alcohol + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21029", "l": "acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27638", "l": "phosphate + xanthosine = alpha-D-ribose 1-phosphate + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29364", "l": "dCMP + H2O => 2'-deoxycytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72364", "l": "chloride(out) + hydrogencarbonate(in) => chloride(in) + hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65115", "l": "2-oxoglutarate + aculene D + O2 <=> aculene C + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112435", "l": "Formation of Elongin BC complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389762", "l": "Phosphorylation of PD-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14924", "l": "(indol-3-yl)acetate + UDP-alpha-D-glucose <=> 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.98.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606324", "l": "Recruitment TBK1 to dsDNA:ZBP1 followed by its activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73454", "l": "adenosine 3',5'-bisphosphate(in) + AMP(out) <=> adenosine 3',5'-bisphosphate(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351948", "l": "Mitochondrial recruitment of Drp1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24327", "l": "6-oxocineole + H(+) + NADPH + O2 <=> 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18825", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose = [(1->6)-alpha-D-glucosyl](n+1) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17102", "l": "H2O + O-acyl-(R)-carnitine => (R)-carnitine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45472", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75823", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] = 5-oxo-(6E,8Z)-octadecadienoate + H(+) + 2 H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13829", "l": "GDP-alpha-D-rhamnose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22821", "l": "3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose => 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-167427", "l": "Opioid dissociates from MOR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49263", "l": "D-galactose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-galactose 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592398", "l": "Activation of proMMP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674095", "l": "PDGFRs bind type II TKI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004528", "l": "phosphodiesterase I activity", "d": ["Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592387", "l": "Fibulin binds elastic fibres (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45405", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate => 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706336", "l": "Active FLT3 binds to SYK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805943", "l": "S100A1 binds TLR4:LY96 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73904", "l": "ATP + ethanolamine + L-glutamate => ADP + gamma-L-glutamylethanolamide + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13149", "l": "A + H(+) + NADPH = AH2 + NADP(+)", "d": []}, {"i": "EC:1.6.99.1", "l": "\"NADPH dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60610", "l": "1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine => 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29332", "l": "fumarate(in) + 2 H(+)(in) => fumarate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60411", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O <=> Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798374", "l": "DYRK2 phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209823", "l": "Tyrosine is hydroxylated to dopa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46230", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein] => apo-[peptidyl-carrier protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23197", "l": "3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine => 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944218", "l": "Association of procollagen type VIII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48826", "l": "a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+) => GDP-beta-L-fucose + Lc4Cer", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0043023", "l": "ribosomal large subunit binding", "d": ["Binding to a large ribosomal subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22791", "l": "dimethylsulfonioacetate + L-homocysteine <=> (methylsulfanyl)acetate + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604446", "l": "HES5 gene expression is stimulated by NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944219", "l": "Association of procollagen type XVI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65741", "l": "2-oxoglutarate + nonyl sufate + O2 => CO2 + H(+) + nonanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682020", "l": "MRN complex binds shortened telomeres (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57008", "l": "5,5'-dehydrodivanillate + H(+) + NADH + O2 = 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72300", "l": "3,3',5-triiodo-L-thyronine(out) + L-glutamate(in) => 3,3',5-triiodo-L-thyronine(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047443", "l": "4-hydroxy-4-methyl-2-oxoglutarate aldolase activity", "d": ["Catalysis of the reaction: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46033", "l": "H2O2 + tetradecanoate => (2S)-hydroxytetradecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49008", "l": "aurachin C + H(+) + NADPH + O2 = aurachin C epoxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19895", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186786", "l": "Autophosphorylation of PDGF beta receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56053", "l": "2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388468", "l": "AVP(20-28) binds AVPR1A,B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.179", "l": "\"methylxanthine N(3)-demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37816", "l": "(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 => 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005174", "l": "CD40 receptor binding", "d": ["Binding to CD40, a receptor found on the surface of all B-lymphocytes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47444", "l": "3-oxo-(7Z-hexadecenoyl)-CoA + CoA = (5Z)-tetradecenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52692", "l": "3-phenyllactate + NADP(+) = 3-phenylpyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75172", "l": "Formation of RAD50:MRE11 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018746", "l": "RHOQ binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60787", "l": "2-oxoglutarate + gibberellin A24 + O2 <=> CO2 + gibberellin A25 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015160", "l": "beta-glucan transmembrane transporter activity", "d": ["Enables the transfer of beta-glucans from one side of a membrane to the other. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51470", "l": "a quinol + pyruvate => (R)-lactate + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035484", "l": "CysS248-MPST:TXN2 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671772", "l": "p-T38-PPP1R14A binds MLCP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69262", "l": "(3R)-3-hydroxy-3-(thiiran-2-yl)propanenitrile + sulfate => (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5333671", "l": "CLCAs self cleave (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64148", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-R + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15747", "l": "[(2->1)-beta-D-fructosyl](n+1) + D-glucose => [(2->1)-beta-D-fructosyl](n) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58654", "l": "rifamycin SV para-naphthoquinone carboxamide => rifamycin SV ortho-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685604", "l": "SLAMF6 binds SLAMF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032770", "l": "Translocation of YAP1 to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33946", "l": "H(+) + 2 L-arginine + 3 NADH + 4 O2 <=> 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132277", "l": "Complement factor H binds to surface-bound C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21964", "l": "an acylcholine + H2O = a carboxylate + choline + H(+)", "d": []}, {"i": "EC:3.1.1.8", "l": "\"cholinesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904841", "l": "TORC2 complex binding", "d": ["Binding to a TORC2 complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42876", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38179", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13148", "l": "4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate <=> alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938773", "l": "RNF144A polyubiquitinates PRKDC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37243", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30225", "l": "2 Fe(II)-[cytochrome c] + H(+) + sulfur => 2 Fe(III)-[cytochrome c] + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69651", "l": "cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13531", "l": "H2O + mesaconate => (3S)-citramalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1222491", "l": "Lactoferrin scavenges iron ions (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67786", "l": "1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol => 2 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10759", "l": "ATP + phosphate + pyruvate <=> AMP + diphosphate + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9733292", "l": "AMY1-3 bind pramlintide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-500717", "l": "Activation of GRIK3 homomer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050175", "l": "phenylalanine dehydrogenase activity", "d": ["Catalysis of the reaction: L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47642", "l": "4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610735", "l": "NUMB binds ITCH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166220", "l": "FA anion diffuses laterally to UCP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32849", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37214", "l": "2',3'-cyclophospho-GMP + H2O <=> guanosine 2'-monophosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5632668", "l": "SMO translocates to the cilium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791177", "l": "Expression of KLHDC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16099", "l": "acetate + H(+) + pyruvate => acetylpyruvate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68674", "l": "16alpha,17beta-estriol 16-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33351", "l": "hexacosanoyl-CoA + sphinganine = CoA + H(+) + N-hexacosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031752", "l": "D5 dopamine receptor binding", "d": ["Binding to a D5 dopamine receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047406", "l": "beta-aspartyl-N-acetylglucosaminidase activity", "d": ["Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-D-glucosamine + L-asparagine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649108", "l": "HTR3A pentamer binds 5HT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2130706", "l": "MHC class II antigen processing (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10571", "l": "luteolin + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63562", "l": "angiotensin II + L-histidyl-L-leucine => angiotensin I + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975633", "l": "atROL binds to RBP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033707", "l": "3''-deamino-3''-oxonicotianamine reductase activity", "d": ["Catalysis of the reaction: 2'-deoxymugineic acid + NAD(P)+ = 3''-deamino-3''-oxonicotianamine + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201443", "l": "Type II receptor phosphorylates type I receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869580", "l": "DEK binds TFAP2A homodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0004660", "l": "protein farnesyltransferase activity", "d": ["Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013108", "l": "GDIs block activation of RHOC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047628", "l": "ADP-thymidine kinase activity", "d": ["Catalysis of the reaction: ADP + thymidine = AMP + thymidine 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781941", "l": "WNTs are secreted in exosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981637", "l": "Complement factor I inactivates C4BP-bound C4b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636439", "l": "PtpA:Ub dephosphorylates p-Y133-VPS33B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102760", "l": "6-deoxocathasterone hydroxylase activity", "d": ["Catalysis of the reaction: 6-deoxycathasterone + O2 + a reduced electron acceptor <=> 6-deoxoteasterone + H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26116", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + epi-cedrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050149", "l": "o-aminophenol oxidase activity", "d": ["Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624494", "l": "RAF1 binds p21 RAS:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53351", "l": "5,6-dihydrouridine(20a) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20a) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912429", "l": "Resolution of meiotic holliday junction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70784", "l": "H(+)(out) + L-aspartate(in) + L-glutamate(out) => H(+)(in) + L-aspartate(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69830", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R,23R)-22,23-dihydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47075", "l": "1-eicosanoylglycerol + H2O <=> eicosanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28095", "l": "di-trans,octa-cis-undecaprenyl diphosphate + H2O => di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657617", "l": "ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878117", "l": "RUNX3 binds ZFHX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.-", "l": "\"Forming phosphoric ester bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43851", "l": "[thioredoxin]-dithiol + arsenate + H(+) <=> [thioredoxin]-disulfide + arsenite + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75292", "l": "glyoxylate(in) + oxalate(out) => glyoxylate(out) + oxalate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12633", "l": "benzoate + H(+) + NADH + O2 = (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)", "d": []}, {"i": "EC:1.14.12.10", "l": "\"benzoate 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70533", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP => 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008558", "l": "ABC-type guanine transporter activity", "d": ["Catalyses the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44463", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol <=> a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33825", "l": "NAD(+) + tetrahydro-4-hydroxyphenylpyruvate => 3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59322", "l": "4-O-beta-D-glucopyranosyl-D-gluconate + H(+) => D-cellobiono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38073", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62937", "l": "H2O + N(4)-acetyl-2'-deoxycytidine => 2'-deoxycytidine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26447", "l": "3-oxopropanoate + CoA + NADP(+) => H(+) + malonyl-CoA + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004141", "l": "dethiobiotin synthase activity", "d": ["Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO2 = ADP + dethiobiotin + 4 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757438", "l": "ASA- translocates from cytosol to ER lumen of GI cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20221", "l": "(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate", "d": []}, {"i": "EC:6.3.4.3", "l": "\"formate--tetrahydrofolate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36605", "l": "(3S)-3-hydroxy-L-enduracididine + CO2 + succinate => 2-oxoglutarate + L-enduracididine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32606", "l": "(6E)-8-hydroxygeraniol + NADP(+) <=> (6E)-8-oxogeraniol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70517", "l": "3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429992", "l": "PARN deadenylates mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60178", "l": "5-methylaminomethyl-2-selenouridine(34) in tRNA + phosphate => 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700154", "l": "Active ALK binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0031072", "l": "heat shock protein binding", "d": ["Binding to a heat shock protein, a protein synthesized or activated in response to heat shock."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033940", "l": "glucuronoarabinoxylan endo-1,4-beta-xylanase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-xylosyl links in some glucuronoarabinoxylans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004990", "l": "oxytocin receptor activity", "d": ["Combining with oxytocin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199112", "l": "CRTAM binds to NECL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29011", "l": "2-oxoglutarate(in) + H(+)(in) = 2-oxoglutarate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75094", "l": "2 chloride(in) + sulfate(out) <=> 2 chloride(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10382", "l": "5-phospho-alpha-D-ribose 1-diphosphate + orotate => diphosphate + orotidine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804100", "l": "HMGB1 binds LPS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22747", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53359", "l": "5,6-dihydrouridine(20b) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20b) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15820", "l": "H2O + O2 + pyridoxamine 5'-phosphate <=> H2O2 + NH4(+) + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694527", "l": "Loss of SAR1B GTPase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983707", "l": "SYK autophosphorylates at the activated BCR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39996", "l": "an N-acylethanolamine + H2O => a fatty acid + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13976", "l": "diphosphate + H(+)(in) + H2O <=> 2 H(+)(out) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39414", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA <=> (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32049", "l": "adenosine 5'-pentaphosphate + AMP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858346", "l": "AMHR2 binds AMH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70708", "l": "6-sulfo-beta-D-quinovose => 6-sulfo-D-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674414", "l": "Sorafenib-resistant PDGFR mutants don't bind sorefenib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624953", "l": "ARL13B binds INPP5E (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426154", "l": "SREBP1A,2 binds the LSS promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39132", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28108", "l": "H(+) + keto-D-tagatose 6-phosphate + NADH => galactitol 1-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381496", "l": "Formation of the IGF:IGFBP3:ALS complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39115", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) = 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39254", "l": "(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH <=> (11Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018526", "l": "2-aminobenzoyl-CoA reductase activity", "d": ["Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 H+ + 2 e- = NH3 + benzoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140912", "l": "membrane destabilizing activity", "d": ["Binding to a membrane and increasing its permeability. This may lead to cell membrane lysis and cell content release."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5336182", "l": "GPR37 binds prosaptide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52790", "l": "Mg(2+) + pheophytin a => chlorophyll a + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12919", "l": "D-glucose + strictosidine aglycone => 3alpha(S)-strictosidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44059", "l": "2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA <=> 2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036217", "l": "dGTP diphosphatase activity", "d": ["Catalysis of the reaction: dGTP + H2O = dGMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12342", "l": "H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68212", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoylglycerol = 1,2-dihexanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37647", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391372", "l": "GNRHR binds GNRH1,2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41854", "l": "3-oxodecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + malonyl-[ACP] + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395320", "l": "Latent TGF-beta-1 binds integrins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69006", "l": "AMP + cremeomycin + diphosphate + H2O => 3-amino-2-hydroxy-4-methoxybenzoate + ATP + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624949", "l": "Assembly of the anterograde IFT train (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48567", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O <=> D-ribose 5-phosphate + trans-zeatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785181", "l": "LMF1,2 bind LIPC dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48297", "l": "H2O + prostaglandin E2 1-glyceryl ester => glycerol + H(+) + prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102301", "l": "gamma-linolenate elongase activity", "d": ["Catalysis of the reaction: malonyl-CoA + gamma-linolenoyl-CoA + H+ = (8Z,11Z,14Z)-3-oxoicosa-8,11,14-trienoyl-CoA + coenzyme A + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8963864", "l": "CUBN dissociates from 25(OH)D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15923", "l": "a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol => 2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689085", "l": "ATXN3 binds polyUb-PARK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694718", "l": "O-glycosylation of 3a is terminated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.30.2", "l": "\"Serratia marcescens nuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27377", "l": "(R)-glycerate + ATP = (2R)-2-phosphoglycerate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.165", "l": "\"glycerate 2-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72782", "l": "chloride + FADH2 + O2 + ochratoxin B <=> FAD + 2 H2O + ochratoxin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110011", "l": "Binding of Grb10 to the insulin receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62444", "l": "L-canavanine + L-ornithine = H(+) + L-arginine + L-canaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61815", "l": "3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose <=> dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9660192", "l": "VDR agonists bind VDR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112042", "l": "Opioid binds MOR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433456", "l": "Recruitment of STATs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047026", "l": "androsterone dehydrogenase (A-specific) activity", "d": ["Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56455", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 12-epi-hapalindole U", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798304", "l": "TP53 binds the E2F7 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15392", "l": "ATP <=> 3',5'-cyclic AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59175", "l": "hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] <=> AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68587", "l": "ATP + H2O + L-tryptophan(out) <=> ADP + H(+) + L-tryptophan(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44119", "l": "eicosan-1-ol + hexadecanoyl-CoA <=> CoA + eicosanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46564", "l": "acetyl-CoA + apo-[ACP] = acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47652", "l": "D-ribitol 1-phosphate + H2O = phosphate + ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446694", "l": "IRAK4 phosphorylates IRAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730847", "l": "Hydrolysis of PIP2 by PLCG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46771", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090524", "l": "cytochrome-b5 reductase activity, acting on NADH", "d": ["Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34748", "l": "15-methylhexadecasphinganine + ATP => 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654422", "l": "Activated FGFR4 binds FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417890", "l": "P2Y5 receptor can bind to LPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50648", "l": "2-(2-methylsulfanyl)ethylmalate = 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050417", "l": "glutamin-(asparagin-)ase activity", "d": ["Catalysis of the reaction: H2O + L-glutamine = NH3 + L-glutamate; and H2O + L-asparagine = NH3 + L-aspartate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23359", "l": "ATP + L-seryl-[rhodopsin] <=> ADP + H(+) + O-phospho-L-seryl-[rhodopsin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700701", "l": "T-type VDCC bind T-type VDCC blockers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14242", "l": "3-amino-4-hydroxybenzaldehyde + acetyl-CoA => 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18280", "l": "a thiol + S-adenosyl-L-methionine <=> a methyl thioether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18362", "l": "a dolichyl D-xylosyl phosphate + L-seryl-[protein] => 3-O-(beta-D-xylosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67451", "l": "(2R)-2-hydroxyoctadecanoyl-CoA <=> formyl-CoA + heptadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5263633", "l": "DYSF, CAV3 and TRIM72 bind (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004161", "l": "dimethylallyltranstransferase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40281", "l": "CoA + O-dodecanoyl-R-carnitine => (R)-carnitine + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204779", "l": "Interaction of Tie2 with Ang1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000319", "l": "BORA binds PLK1 and AURKA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64279", "l": "chrysophanol-9-anthrone + O2 <=> chrysophanol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211874", "l": "CYP2S1 4-hydroxylates atRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14556", "l": "(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate <=> 2-oxoglutarate + cephalosporin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35541", "l": "albonoursin + H2O2 => cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-354173", "l": "Activation of Rap1 by cytosolic GEFs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021609", "l": "ESR-associated SRC autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874162", "l": "ATF6B:HSPA5 (ATF6-beta:BiP) dissociates and HSPA5 binds unfolded protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76111", "l": "4-methylumbelliferone beta-D-glucuronate + H2O = 4-methylumbelliferone + D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54728", "l": "acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": []}, {"i": "EC:2.1.3.15", "l": "\"acetyl-CoA carboxytransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190520", "l": "Association of Golgi  transport vesicles with microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25437", "l": "(2E,6E)-farnesyl diphosphate => (E,R)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75612", "l": "H2O + plasmodiophorol A => plasmodiophorol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3828025", "l": "DCN (decorin) degradation by MMP14 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20752", "l": "A + 2 cob(II)alamin + 2 H(+) + 2 H2O = AH2 + 2 aquacob(III)alamin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1015699", "l": "ISGF3 binds the ISRE promoter elements in IFN-stimulated genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295632", "l": "PPA2A dephosphorylates SPRY2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694447", "l": "mRNA2 is translated to Spike (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13119", "l": "3-(pyrazol-1-yl)-L-alanine + acetate + H(+) => O-acetyl-L-serine + pyrazole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71421", "l": "3,3',5-triiodo-L-thyronine(in) + L-tyrosine(out) => 3,3',5-triiodo-L-thyronine(out) + L-tyrosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37527", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381608", "l": "cAMP activates EPAC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9676257", "l": "Formation of the SET1A complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70051", "l": "2-oxoadipate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9681616", "l": "AP2 binds chlorpromazine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75172", "l": "GTP + NAD(+) => GDP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18781", "l": "H(+) + malonyl-CoA = acetyl-CoA + CO2", "d": []}, {"i": "EC:4.1.1.9", "l": "\"malonyl-CoA decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018634", "l": "alpha-pinene monooxygenase [NADH] activity", "d": ["Catalysis of the reaction: alpha-pinene + NADH + H+ + O2 = NAD+ + H2O + alpha-pinene oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18286", "l": "an N-acyl-D-aspartate + H2O => a carboxylate + D-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003853", "l": "2-methylacyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25921", "l": "A + H2O + quinolin-7-ol => 7-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202722", "l": "CD48 binds CD244 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33413", "l": "(S)-malyl alpha-D-glucosaminide + acetate => (S)-malyl N-acetyl-alpha-D-glucosaminide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429449", "l": "Syk activation leads to SLP-76 activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708457", "l": "HM13 cleaves HMOX1 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201634", "l": "Caspase-mediated cleavage of FADK 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42480", "l": "2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36436", "l": "a 1,2-diacyl-sn-glycero-3-phosphate(in) => a 1,2-diacyl-sn-glycero-3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47297", "l": "dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49876", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2752115", "l": "SPP1 (osteopontin) binds CD44 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004415", "l": "hyalurononglucosaminidase activity", "d": ["Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34412", "l": "cannabigerolate + O2 => cannabidiolate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75045", "l": "L-cystine(in) + L-leucine(out) => L-cystine(out) + L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37618", "l": "(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31013", "l": "camelliol C => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54102", "l": "H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20943", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62766", "l": "4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66912", "l": "avenanthramide C + S-adenosyl-L-methionine = avenanthramide B + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45457", "l": "H2O + N-dodecanoylethanolamine => dodecanoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380574", "l": "Dopamine synaptic vesicle docking and priming (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.054311793581761", "identifiers": [{"i": "GO:0140994", "l": "RNA polymerase II CTD heptapeptide repeat modifying activity", "d": ["A catalytic activity that acts on the RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS). Reversible modifications cof the RNA polymerase II CTD repeats contribute to regulation of RNA polymerase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66904", "l": "A + cannabinerolate = AH2 + cannabichromenate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052690", "l": "trichloro-p-hydroquinone reductive dehalogenase activity", "d": ["Catalysis of the reaction: 2,3,6-trichlorohydroquinone + 2 glutathione = 2,6-dichlorohydroquinone + glutathione disulfide + HCl."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047582", "l": "4-methyleneglutaminase activity", "d": ["Catalysis of the reaction: 4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-169719", "l": "Secreted CD14 binds LPS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204169", "l": "PDP dephosphorylates p-lipo-PDH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43579", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47277", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32309", "l": "H2O + leukotriene A4 => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66229", "l": "asc-C13-CoA + O2 => asc-DeltaC13-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37843", "l": "1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66139", "l": "acetyl-CoA + tyramine <=> CoA + H(+) + N-acetyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9015111", "l": "Factor Xa inhibitors binds Xa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36847", "l": "FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)", "d": []}, {"i": "EC:2.7.1.180", "l": "\"FAD:protein FMN transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050445", "l": "asparagusate reductase activity", "d": ["Catalysis of the reaction: 3-mercapto-2-mercaptomethylpropanoate + NAD+ = asparagusate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938356", "l": "RMB14 binds RUNX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46928", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": []}, {"i": "EC:5.1.3.34", "l": "\"monoglucosyldiacylglycerol epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629373", "l": "NEIL3 recognizes and binds to spiroiminodihydantoin in telomeric DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40725", "l": "(9E)-octadecenoate + CoA + H(+) => (9E)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61983", "l": "H(+) + NADPH + ubiquinone-10 <=> NADP(+) + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21521", "l": "2 Fe(III)-[cytochrome b1] + formate => CO2 + 2 Fe(II)-[cytochrome b1] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71658", "l": "an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O <=> a thymidine in DNA + ADP-D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34217", "l": "4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH => 4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851298", "l": "GPR143 binds L-Dopa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50843", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75079", "l": "Formation of AT-AC C complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26101", "l": "(2R)-homocitrate = cis-homoaconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58739", "l": "H2O + TTP <=> 5-methyl-UMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013023", "l": "RHOB GEFs activate RHOB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197958", "l": "FPGS-2 transforms THF to THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62035", "l": "a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O <=> a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102139", "l": "2-hydroxy-6-oxo-6-(2'-aminophenyl)-hexa-2,4dienoate hydrolase activity", "d": ["Catalysis of the reaction: (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> H+ + anthranilate + (2E)-2-hydroxypenta-2,4-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59305", "l": "3'-phosphoadenylyl sulfate + firefly L-luciferin => adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33538", "l": "H2O + lanosteryl ester <=> a carboxylate + H(+) + lanosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12639", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP => (5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534388", "l": "Progesterone Activation Of CatSper (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419645", "l": "Dimerization of LIMK1 by Hsp90 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666008", "l": "SCAI binds SRF:MKL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61998", "l": "CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein] => L-lysyl-[protein] + lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379993", "l": "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1369028", "l": "ABCAs mediate lipid efflux (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19682", "l": "ATP + biotin + CoA => AMP + biotinyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69691", "l": "ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine = ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726875", "l": "HCNs:cAMP bind SNIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62863", "l": "acetyl-CoA + 7 H(+) + 7 malonyl-CoA <=> 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60237", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56402", "l": "(3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+) => [(3R)-hydroxybutanoate](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903924", "l": "estradiol binding", "d": ["Binding to estradiol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047743", "l": "chlordecone reductase activity", "d": ["Catalysis of the reaction: chlordecone alcohol + NADP+ = chlordecone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68449", "l": "13-cis-lycopene + O2 => (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 13-cis-10'-apo-lycopenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177926", "l": "Dephosphorylation of PAG by SHP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654167", "l": "Activated FGFR1 binds PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050500", "l": "1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity", "d": ["Catalysis of the reaction: phosphate + beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine = N-acetyl-D-glucosamine + alpha-D-galactopyranose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.33", "l": "\"fruit bromelain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10307", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46803", "l": "H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672961", "l": "PP2A dephosphorylates inactive RAFs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23941", "l": "D-gluconate + NAD(+) => 5-dehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443418", "l": "GP1b signaling involves c-Src (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47963", "l": "H2O + N(tele)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42544", "l": "uridine(32) in tRNA = pseudouridine(32) in tRNA", "d": []}, {"i": "EC:5.4.99.28", "l": "\"tRNA pseudouridine(32) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16815", "l": "anthranilate + H(+) + L-alanine => H2O + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37396", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63061", "l": "5-methylorsellinate + ATP + H(+) + NADPH => 2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68615", "l": "Formation of ORC(1-6) complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22823", "l": "3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683831", "l": "CCDC59 binds TTF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.-.-", "l": "\"Isomerases altering macromolecular conformation\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28731", "l": "H(+)(out) + L-leucine(in) = H(+)(in) + L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46194", "l": "3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73746", "l": "2 H(+)(out) + serotonin(in) <=> 2 H(+)(in) + serotonin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212380", "l": "Formation of TRAP coactivator complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9017491", "l": "RHOJ GEFs activate RHOJ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193703", "l": "IKKbeta is activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40673", "l": "NH4(+) + pyruvate => 2-iminopropanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047869", "l": "dimethylpropiothetin dethiomethylase activity", "d": ["Catalysis of the reaction: S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41563", "l": "(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 <=> (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72672", "l": "The 60S subunit joins the translation initiation complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13776", "l": "(S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50885", "l": "(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O => (9Z-octadecenoyl)-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042950", "l": "salicin transmembrane transporter activity", "d": ["Enables the transfer of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390597", "l": "Release Of ADP From Myosin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11093", "l": "NAD(+) + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690701", "l": "SHP1 binds p-CD22 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862700", "l": "CMKLR1 binds Resolvin E1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46351", "l": "(2E)-octenoyl-CoA + H2O <=> 3-hydroxyoctanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801762", "l": "REG3A oligomerize to form a pore complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6794346", "l": "NRXNs bind NLGNs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12653", "l": "(S)-malate + NAD(+) = CO2 + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64684", "l": "L-threonyl-[protein] + UDP-alpha-D-glucose = 3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043729", "l": "2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity", "d": ["Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690873", "l": "ACO1 binds 4Fe-4S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55970", "l": "(+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine => (+)-kolavelool + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9676264", "l": "Formation of the SET1B complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177934", "l": "EGFR autophosphorylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55448", "l": "a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.81", "l": "\"flavonoid 3',5'-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67517", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65292", "l": "2 ATP + butan-2-one + 3 H2O + hydrogencarbonate = 3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14337", "l": "3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate = adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate", "d": []}, {"i": "EC:2.8.2.7", "l": "\"UDP-N-acetylgalactosamine-4-sulfate sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10010", "l": "[protein]-disulfide + an alcohol + H2O => [protein]-dithiol + a hydroperoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69963", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623643", "l": "RDH13 reduces atRAL to atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0018488", "l": "aryl-aldehyde oxidase activity", "d": ["Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77608", "l": "Binding of A1CF to stem-looped RNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13696", "l": "(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64013", "l": "acetyl-CoA + AH2 + 3 malonyl-CoA + 3 S-adenosyl-L-methionine => A + 3 CO2 + 4 CoA + fumigermin + H2O + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75573", "l": "11-O-acetylcyathin A3 + CoA => acetyl-CoA + cyathin A3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41665", "l": "dihydrochelirubine + NAD(+) => chelirubine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176517", "l": "SULTs transfer (SO4)2- group to PREG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018497", "l": "1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity", "d": ["Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethene + 2 H+ + 2 e- = 1-chloro-2,2-bis(4-chlorophenyl)ethane. 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU; 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38807", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177926", "l": "Dephosphorylation of PAG by SHP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50358", "l": "4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+) => 4-hydroxy-6-methylpretetramide + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944454", "l": "mTORC1 phosphorylates MAF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29610", "l": "H2O + NAD(+) + nitrous oxide <=> H(+) + NADH + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10467", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O <=> n acetate + chitosan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21889", "l": "(1S,2S)-OPC-8 + NADP(+) => (9S,13S,15Z)-12-oxophyto-10-15-dienoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57889", "l": "a quinone + 5 H(+)(in) + NADH => a quinol + 4 H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72964", "l": "acetoacetate(out) + 2 Na(+)(out) => acetoacetate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429036", "l": "SLC2A9 transports Fru, Glc, urate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18170", "l": "4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204779", "l": "Interaction of Tie2 with Ang1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047559", "l": "3-dehydro-L-gulonate 2-dehydrogenase activity", "d": ["Catalysis of the reaction: 3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561072", "l": "OCT3 mediates renal uptake of organic cations (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64000", "l": "(4R)-hydroxysphinganine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824236", "l": "MSGN1 and LEF1:CTNNB1 bind the DLL1 gene in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.138", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56446", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14301", "l": "4-pyridoxolactone + H2O = 4-pyridoxate + H(+)", "d": []}, {"i": "EC:3.1.1.27", "l": "\"4-pyridoxolactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56481", "l": "(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13147", "l": "alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine => 4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102522", "l": "tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 4-demethylwyosine37 in tRNAPhe <=> 5'-S-methyl-5'-thioadenosine + H+ + 7-[(3S)-3-amino-3-carboxypropyl]-4-demethylwyosine37 in tRNAPhe."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74922", "l": "a (2E)-2-fatty-enoyl-AMP + holo-[ACP] <=> a (2E)-enoyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647978", "l": "pro-RAS proteins are farnesylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53960", "l": "4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 = 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.13", "l": "\"4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71125", "l": "AMP + 2 CO2 + 2 CoA + diphosphate + hispidin => (E)-caffeate + ATP + H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70699", "l": "H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out) = H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14507", "l": "glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite => 2 glutathione + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061486", "l": "high-affinity fructose transmembrane transporter activity", "d": ["Enables the transfer of fructose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749464", "l": "TP53 binds the IKBIP gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50551", "l": "prostaglandin E1 <=> H2O + prostaglandin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20832", "l": "ATP + guanine(out) + H2O = ADP + guanine(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.6.2.6", "l": "\"ABC-type guanine transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23015", "l": "a fatty acid + S-adenosyl-L-methionine <=> a fatty acid methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66885", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38220", "l": "(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18938", "l": "an N-acyl-L-homoserine lactone + H2O => a carboxylate + L-homoserine lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51503", "l": "ATP + N-acetyl-D-muramate <=> ADP + H(+) + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679205", "l": "ULK1 phosphorylates Beclin-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730521", "l": "SARS-CoV-2 3a induces potassium efflux (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814374", "l": "Kazrin binds periplakin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71019", "l": "L-phenylalanine(out) + L-valine(in) = L-phenylalanine(in) + L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49158", "l": "dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine => dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707586", "l": "FeHM oxidises LDL,HDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75770", "l": "(9Z)-hexadecenoate + H2O <=> 10-hydroxyhexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051009", "l": "O-acetylhomoserine sulfhydrylase activity", "d": ["Catalysis of the reaction: O-acetyl-L-homoserine + hydrogen sulfide = homocysteine + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73796", "l": "dimethylallyl diphosphate + neoechinulin A => diphosphate + isoechinulin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977605", "l": "Factor H displaces Bb (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36488", "l": "agmatine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033889", "l": "N-sulfoglucosamine-3-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669012", "l": "EDA binds EDAR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802837", "l": "Loss-of-function NF1 variants don't stimulate RAS GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27578", "l": "(R)-N-tert-butylpiperazine-2-carboxamide + H2O = (R)-piperazine-2-carboxylate + tert-butylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689111", "l": "PARK2 autoubiquitinates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41482", "l": "an episterol ester + CoA => an acyl-CoA + episterol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004567", "l": "beta-mannosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111238", "l": "Formation of ADAR2  homodimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391941", "l": "BLT receptors can bind LTB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16103", "l": "n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+) => n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28531", "l": "H2O + XMP => phosphate + xanthosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683925", "l": "ULK1 is dephosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68612", "l": "H(+) + NADPH + prostaglandin E1 = NADP(+) + prostaglandin F1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.13", "l": "\"phospho-N-acetylmuramoyl-pentapeptide-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62848", "l": "GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21929", "l": "3-dehydro-L-gulonate + NADP(+) => 2,3-dioxo-L-gulonate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60173", "l": "5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate => (2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917730", "l": "Cargo Recognition And Sorting (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050154", "l": "opheline kinase activity", "d": ["Catalysis of the reaction: ATP + guanidinoethyl methyl phosphate = N'-phosphoguanidinoethyl methylphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29937", "l": "cytosine(out) + H(+)(out) => cytosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64204", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20588", "l": "loganin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10041", "l": "adenosine 3',5'-bisphosphate + H2O => AMP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23464", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.174", "l": "\"glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39651", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O = 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": []}, {"i": "EC:3.7.1.21", "l": "\"6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74097", "l": "ADP + an L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31540", "l": "(2S)-naringenin + S-adenosyl-L-methionine => (2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71883", "l": "GMP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-GMP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54556", "l": "a 5'-end ribonucleotide-tRNA(His) + ATP + H(+) = a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20452", "l": "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 <=> 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35029", "l": "ADP + H(+) + phosphate + tungstate(out) => ATP + H2O + tungstate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052634", "l": "C-19 gibberellin 2-beta-dioxygenase activity", "d": ["Catalysis of the reaction: a C-19 gibberellin + 2-oxoglutarate + O2 = a C-19 2-beta-hydroxygibberellin + succinate + CO2. C-19 gibberellin refers to a gibberellin with nineteen carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11626", "l": "acetone oxime + pyruvate => 2-(hydroxyimino)propanoate + acetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021050", "l": "HSBP1 oligomer binds ESRs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37505", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40623", "l": "H2O + tritetradecanoylglycerol = 2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042019", "l": "interleukin-23 binding", "d": ["Binding to interleukin-23."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32975", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63062", "l": "2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+) => 5-methylorsellinate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51696", "l": "desmethylxanthohumol + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + xanthohumol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607058", "l": "Activated protein C:PROCR binds F2R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9649735", "l": "Intrinsic nucleotide exchange on RAS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604360", "l": "Initial activation of proMMP2 by MMP14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69169", "l": "H2O + NAD(+) + spermine monoaldehyde => 2 H(+) + N-(2-carboxyethyl)spermidine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11388", "l": "an 11beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.146", "l": "\"11beta-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627104", "l": "XIAP binds CASP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51542", "l": "(S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72308", "l": "L-glutamate(in) + taurocholate(out) => L-glutamate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102811", "l": "geraniol 10-hydroxylase activity", "d": ["Catalysis of the reaction: geraniol + O2 + NADPH + H+ <=> (6E)-8-hydroxygeraniol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21701", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.75", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29190", "l": "succinate + ubiquinone-8 <=> fumarate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626928", "l": "CREBBP binds FOXO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913374", "l": "Phosphorylated SHC1 recruits SHIP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247839", "l": "Retromer associates with WLS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030771", "l": "N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity", "d": ["Catalysis of the reaction: N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine(1+) = N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70242", "l": "a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol <=> an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159733", "l": "Furin cleaves pro-factor X to factor X (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72631", "l": "Formation of the cap-binding eIF4F complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57783", "l": "2-chloro-4-nitrotoluene + NADH + O2 <=> 3-chloro-4-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48779", "l": "O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174058", "l": "Degradation of multiubiquitinated Cdh1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24256", "l": "ATP + kanamycin A = ADP + H(+) + kanamycin 3'-phosphate", "d": []}, {"i": "EC:2.7.1.95", "l": "\"kanamycin kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097358", "l": "D-leucyl-tRNA(Leu) deacylase activity", "d": ["Catalysis of the reaction: D-leucyl-tRNA(Leu) = D-leucine + tRNA(Leu). Hydrolysis of the removal of D-leucine from residues in charged tRNA(Leu)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626699", "l": "MARK4 binds ODF2 in the centriole (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29417", "l": "(S)-lactate(out) + H(+)(out) => (S)-lactate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27721", "l": "H2O + IMP <=> inosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11198", "l": "alpha-ribazole 5'-phosphate + H(+) + nicotinate => 5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69355", "l": "2 (E)-prop-1-en-1-SO-peroxol <=> H2O + thiosulfinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.20", "l": "\"ribonuclease U2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57239", "l": "GMP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58417", "l": "(E)-4-hydroxynon-2-en-1-ol + NADP(+) => (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3247836", "l": "Retromer recycles WLS to the Golgi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134954", "l": "DHX9 binds DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877192", "l": "RUNX1 binds FOXP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34028", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) => (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8866277", "l": "AP-2 directly binds some endocytic cargo (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130349", "l": "Generation of CLIP from lip10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429698", "l": "PRKD1,2,3 phosphorylates CERT1-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53691", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O <=> (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193650", "l": "p75NTR binds to NADE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909721", "l": "Translocation of ISGF3 complex to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54955", "l": "ATP + CoA + nonanoate <=> AMP + diphosphate + nonanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102061", "l": "endo-beta-bergamotene synthase activity", "d": ["Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate <=> (+)-endo-beta-bergamotene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46569", "l": "5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350362", "l": "ROK phosphorylates MBS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102218", "l": "starch, H2O dikinase activity", "d": ["Catalysis of the reaction: n ATP + n H2O + starch = n AMP + n hydrogenphosphate + a 6-phosphogluco-amylopectin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66002", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+) => (6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51129", "l": "A + an aliphatic amine + H2O => AH2 + an aldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015432", "l": "ABC-type bile acid transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O -> bile acid(out) + ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621399", "l": "SCD5 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454928", "l": "ABCG4 may mediate cholesterol efflux (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48924", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E)) = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49807", "l": "2-methylpropan-1-amine + FMNH2 + O2 <=> FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71141", "l": "3 A + 10 CO2 + 11 CoA + cordypyrone A + 8 H2O + 8 NADP(+) => acetyl-CoA + 3 AH2 + 18 H(+) + 10 malonyl-CoA + 8 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40116", "l": "H2O + hexanoyl-CoA => CoA + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001642", "l": "group III metabotropic glutamate receptor activity", "d": ["A G protein-coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33058", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O <=> diphosphate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19832", "l": "a primary alcohol + O2 <=> an aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202307", "l": "Change of PKC theta conformation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853745", "l": "RET binds GFRA1,GFRA3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392212", "l": "G alpha (i) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45035", "l": "4 Fe(III)-[cytochrome c] + H2O + hydroxylamine <=> 4 Fe(II)-[cytochrome c] + 5 H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67724", "l": "CMP(out) + CMP-N-acetyl-beta-neuraminate(in) = CMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663170", "l": "p-BMAL1:p-CLOCK,NPAS2 binds BHLHE40 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20077", "l": "guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.34", "l": "\"tRNA (guanosine(18)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23086", "l": "7-methyl-3-oxooct-6-enoyl-CoA + acetate => 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0140142", "l": "nucleocytoplasmic carrier activity", "d": ["Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047713", "l": "galactitol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: galactitol + NAD+ = D-tagatose + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70155", "l": "6alpha-hydroxy-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] = 28-norcastasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018766", "l": "RHOU binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59015", "l": "cycloartenol + S-adenosyl-L-methionine <=> 24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051538", "l": "3 iron, 4 sulfur cluster binding", "d": ["Binding to a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070774", "l": "phytoceramidase activity", "d": ["Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848339", "l": "PNPLA5 hydrolyzes TAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69475", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose <=> a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0004509", "l": "steroid 21-monooxygenase activity", "d": ["Catalysis of the reaction: A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O2 = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194796", "l": "botB LC cleaves target cell VAMP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209566", "l": "TRAF6 is auto-ubiquitinated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48260", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 = CMP + ganglioside GD1a + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450550", "l": "PKCalpha phosphorylates HuR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266328", "l": "CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-481044", "l": "Surface deployment of platelet alpha granule membrane components (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48210", "l": "(2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12078", "l": "an aromatic aldehyde + H(+) + NADH => an aromatic primary alcohol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40608", "l": "1-tetradecanoyl-sn-glycerol + H2O => glycerol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72886", "l": "2 3-phenylpyruvate + 2 ATP <=> 2 AMP + 2 diphosphate + H(+) + polyporic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31127", "l": "3-O-methylgallate + O2 = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102751", "l": "UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + a glucosyl-glycogenin = (1,4-alpha-D-glucosyl)n-glucosyl glucogenin + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43725", "l": "(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41548", "l": "8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.307", "l": "\"8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)-tetracenomycin-C 4'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112510", "l": "IL6ST is tyrosine phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0033250", "l": "penicillinase activity", "d": ["Catalysis of the reaction: a penicillin + H2O = a substituted beta-amino acid derivative of the penicillin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74723", "l": "Endosome acidification (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.461271292734189", "identifiers": [{"i": "GO:0015291", "l": "secondary active transmembrane transporter activity", "d": ["Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44292", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44167", "l": "ATP + H2O <=> adenine + D-ribose 5-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12681", "l": "creatinine + H(+) + H2O = N-methylhydantoin + NH4(+)", "d": []}, {"i": "EC:3.5.4.21", "l": "\"creatinine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44117", "l": "eicosan-1-ol + hexadecanoyl-CoA => CoA + eicosanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43518", "l": "2-carboxy-5-(dihydroxymethyl)furan => 2-carboxy-5-formylfuran + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009905", "l": "ent-copalyl diphosphate synthase activity", "d": ["Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = ent-copalyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51403", "l": "octadecanoyl-CoA + serotonin <=> CoA + H(+) + N-octadecanoyl-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019108", "l": "aryl-aldehyde dehydrogenase (NAD) activity", "d": ["Catalysis of the reaction: an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37374", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O <=> a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66237", "l": "IC-asc-C9-CoA + O2 => H2O2 + IC-asc-DeltaC9-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25852", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.5", "l": "\"acyl-CoA 11-(Z)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36083", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75891", "l": "Abortive Initiation After Second Transition (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0072374", "l": "carotene epsilon hydroxylase activity", "d": ["Catalysis of the reaction: a carotene + NADPH + O2 + H+ = a beta-ring hydroxylcarotene + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42801", "l": "15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) => all-trans-4,4'-diaponeurosporene + 3 FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72821", "l": "L-ornithine(in) + N(omega),N(omega)-dimethyl-L-arginine(out) => L-ornithine(out) + N(omega),N(omega)-dimethyl-L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13683", "l": "a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249378", "l": "STING recruits TBK1 and STAT6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24689", "l": "H2O + N-formylmethanofuran <=> formate + methanofuran", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047402", "l": "protein-glucosylgalactosylhydroxylysine glucosidase activity", "d": ["Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose. The enzyme specifically hydrolyzes glucose from alpha-D-glucosyl- (1->2)-beta-D-galactosyl disaccharide units that are linked to hydroxylysine residues of collagen and collagen-like proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983696", "l": "The Immunoglobulin of the BCR binds antigen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52908", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + O2 = 3-dimethylallyl-4-hydroxymandelate + CO2", "d": []}, {"i": "EC:1.13.11.83", "l": "\"4-hydroxy-3-prenylphenylpyruvate oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63282", "l": "a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68810", "l": "alpha-D-glucose + D-fructose => 6-O-alpha-D-glucopyranosyl-D-fructose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12050", "l": "3-oxoadipyl-CoA + succinate => 3-oxoadipate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.7.1", "l": "\"pyruvate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54026", "l": "(3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate => 2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.18.5", "l": "\"sphingolipid C4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62297", "l": "(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) => (+)-malbrancheamide + 2 FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64913", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O => a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444476", "l": "FPRL2 receptor binds a wide range of ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60690", "l": "(11R)-dihydroartemisinate + 2 H(+) + NADH => (11R)-dihydroartemisinic aldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37937", "l": "8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O => (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10384", "l": "cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate = beta-cyclopiazonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50808", "l": "glutathione + prostaglandin J2 = prostaglandin J2-S-(S)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694579", "l": "Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686699", "l": "Fusion and Release of SARS-CoV-1 Nucleocapsid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55445", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] => cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421831", "l": "trans-Golgi Network Coat Assembly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29626", "l": "alpha-maltopentaose + beta-maltose <=> alpha-maltohexaose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54842", "l": "H2O + NADP(+) + pentyl propanoate => H(+) + NADPH + O2 + octan-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047802", "l": "cysteine-conjugate transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = (4-bromophenylsulfanyl)pyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21006", "l": "2-dehydropantolactone + AH2 => (R)-pantolactone + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749253", "l": "Formation of MCM2-7 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985627", "l": "RUNX2 and RB1 bind the COL1A1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708457", "l": "HM13 cleaves HMOX1 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.2", "l": "\"dihydropyrimidine dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53245", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59047", "l": "dammarenediol-II + UDP-alpha-D-glucose <=> (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44589", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53031", "l": "lithocholate + UDP-alpha-D-glucuronate <=> H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37526", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0016751", "l": "S-succinyltransferase activity", "d": ["Catalysis of the transfer of a succinyl group to a sulfur atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.203", "l": "\"carboxymethylcellulase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42532", "l": "uridine(55) in tRNA = pseudouridine(55) in tRNA", "d": []}, {"i": "EC:5.4.99.25", "l": "\"tRNA pseudouridine(55) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167115", "l": "Addition of nucleotides between position +11 and +30 on HIV-1 transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434650", "l": "MATEs mediate extrusion of xenobiotics (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876789", "l": "CARNMT1 methylates CARN to Anserine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16216", "l": "3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004581", "l": "dolichyl-phosphate beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14732", "l": "beta-D-fructose 1,6-bisphosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26445", "l": "a ubiquinone + ethanol <=> a ubiquinol + acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032896", "l": "palmitoyl-CoA 9-desaturase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042380", "l": "hydroxymethylbutenyl pyrophosphate reductase activity", "d": ["Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44062", "l": "2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA => 2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14151", "l": "H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP => luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5227009", "l": "ABCF1 binds EIF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382056", "l": "Crk binds to the active PDGF receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65494", "l": "5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine => [mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849906", "l": "SALM1 binds NMDA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617887", "l": "HOXC4 chromatin is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19228", "l": "glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781953", "l": "YOD1 binds VCP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33432", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate => (3E)-2-oxohex-3-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23561", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate => adenosylcob(III)alamin 5'-phosphate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.413456430472493", "identifiers": [{"i": "GO:0101005", "l": "deubiquitinase activity", "d": ["An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated."]}, {"i": "REACT:R-HSA-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60343", "l": "N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57950", "l": "3-methylcatechol + H2O + NAD(+) => 2-hydroxytoluene + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53134", "l": "a 3-oxo-Delta(1,4)-steroid + AH2 => A + a 3-oxo-Delta(4)-steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014456", "l": "GDIs block activation of RHOG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18163", "l": "3-oxohexadecanoyl-CoA + CoA => acetyl-CoA + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72936", "l": "(S)-lactate(out) + 2 Na(+)(out) => (S)-lactate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33666", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34654", "l": "3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine <=> 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57447", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61300", "l": "5-deoxy-D-ribulose 1-phosphate = acetaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12294", "l": "AMP + diphosphate + H(+) + L-seryl-tRNA(Ser) => ATP + L-serine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58033", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626938", "l": "Beta-catenin binds SOX proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37590", "l": "2-oxoglutarate + D-lysine <=> 6-amino-2-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58900", "l": "1-carboxybiuret + H2O = NH4(+) + urea-1,3-dicarboxylate", "d": []}, {"i": "EC:3.5.1.131", "l": "\"1-carboxybiuret hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462014", "l": "Alpha-defensins form biologically active dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16221", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.223", "l": "\"glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54052", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + tau-cadinol", "d": []}, {"i": "EC:4.2.3.173", "l": "\"tau-cadinol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875817", "l": "MET phosphorylates STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61220", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39388", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA => (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11394", "l": "1D-myo-inositol 1,3,4-trisphosphate + phosphate => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73749", "l": "(R)-noradrenaline(out) + 2 H(+)(in) => (R)-noradrenaline(in) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64653", "l": "(E)-4-coumaraldehyde + CoA + NADP(+) => (E)-4-coumaroyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73116", "l": "quercetin + S-adenosyl-L-methionine => H(+) + rhamnetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62196", "l": "2 Fe(III)-[cytochrome c] + propan-2-ol = acetone + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340587", "l": "RNF43 frameshift mutants show enhanced WNT siganling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601888", "l": "Unknown nuclease cleaves pre-piRNA in 4xMeR-PIWIL1:pre-piRNA:TDRD6:TDRKH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14402", "l": "chlordecone alcohol + NADP(+) => chlordecone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47556", "l": "H2O + taurodeoxycholate = deoxycholate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429449", "l": "Syk activation leads to SLP-76 activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603784", "l": "PEX19:class I PMP binds PEX3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14266", "l": "(S)-4-amino-5-oxopentanoate => 5-aminolevulinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37948", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75626", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate <=> 14-oxo-15-hydroxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49241", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) => L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724685", "l": "IgE binds omalizumab (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26056", "l": "GTP + H(+) + valienol 1-phosphate => diphosphate + GDP-valienol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54597", "l": "2-oxoglutarate + hexadecanoyl-CoA + O2 => 2-hydroxyhexadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53302", "l": "H(+) + N-carbamoyl-D-methionine => D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74711", "l": "Phosphorylation of IRS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73277", "l": "4',7,8-trihydroxy-3'-methoxyflavone-7-olate + H(+) + S-adenosyl-L-homocysteine => 3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24869", "l": "5'-deoxyadenosine + phosphate = 5-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48203", "l": "H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA <=> reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.104", "l": "\"5-phospho-D-xylono-1,4-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22257", "l": "a (3R)-3-hydroxyacyl-CoA + NADP(+) => a 3-oxoacyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23949", "l": "4-hydroxybutanoate + NAD(+) => H(+) + NADH + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374919", "l": "Noradrenaline clearance from the synaptic cleft (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688797", "l": "ATXN3 family cleave Ub chains (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65090", "l": "asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => asperaculane E + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55425", "l": "(3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] => (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627106", "l": "SMAC (DIABLO) forms dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014454", "l": "RHOG translocates to the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73101", "l": "3'-dephospho-CoA(out) + AMP(in) => 3'-dephospho-CoA(in) + AMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6795667", "l": "MDM2 translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50275", "l": "(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O <=> resolvin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67171", "l": "2-oxoglutarate + 3-hydroxy-L-phenylalanine <=> 3-(3-hydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174124", "l": "Dephosphorylation of phospho-Cdh1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433864", "l": "IRAK2 binds to the IRAK4 accociated  with the complex of the activated TLR : TIRAP : MyD88 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15176", "l": "H(+) + H2O2 + NADPH <=> 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11459", "l": "N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482778", "l": "CL is hydrolyzed to MLCL by PLA2G6 (IM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047054", "l": "berbamunine synthase activity", "d": ["Catalysis of the reaction: (S)-N-methylcoclaurine + (R)-N-methylcoclaurine + [reduced NADPH--hemoprotein reductase] + O2 = berbamunine + [oxidized NADPH--hemoprotein reductase] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57529", "l": "a 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O => a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58209", "l": "A + dihydroalstonine => AH2 + alstonine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047445", "l": "3-hydroxy-3-isohexenylglutaryl-CoA lyase activity", "d": ["Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA + 4 H+ = 7-methyl-3-oxooct-6-enoyl-CoA + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68261", "l": "D-serine(in) + Na(+)(in) => D-serine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390598", "l": "Myosin Binds ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445076", "l": "Phosphorylation of Y1229 in L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52647", "l": "D-xylono-1,4-lactone 5-phosphate + H2O <=> 5-phospho-D-xylonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985153", "l": "OASL binds DDX58 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54088", "l": "3,4-dihydroxyphenylacetate + H(+) + NADH + O2 = 2,4,5-trihydroxyphenylacetate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2176445", "l": "SMURF2 binds SMAD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62034", "l": "a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54497", "l": "ent-copalyl diphosphate => diphosphate + ent-atiserene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018573", "l": "NOTCH3 binds activated EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047653", "l": "allantoin racemase activity", "d": ["Catalysis of the reaction: (S)-(+)-allantoin = (R)-(-)-allantoin."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0046977", "l": "TAP binding", "d": ["Binding to TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034947", "l": "terephthalate decarboxylase activity", "d": ["Catalysis of the reaction: terephthalate + H2O = benzoate + HCO3-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372719", "l": "aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56494", "l": "gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => hederagenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696997", "l": "USP24 deubiquitinates DDB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48543", "l": "1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O <=> dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16475", "l": "5-oxohexanoate + H(+) => cyclohexane-1,3-dione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140857", "l": "histone H3T45 kinase activity", "d": ["Catalysis of the reaction: histone H3-threonine (position 45) + ATP = histone H3-phosphothreonine (position 45) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 45 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10747", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) <=> 3,4-dihydroxybenzoate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549385", "l": "CRY:PER:Kinase complex translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55664", "l": "2 AH2 + echinenone + 2 O2 = 2 A + canthaxanthin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798748", "l": "Exocytosis of secretory granule lumen proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66882", "l": "10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40884", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10119", "l": "6-phospho-D-gluconate + NADP(+) <=> CO2 + D-ribulose 5-phosphate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070579", "l": "methylcytosine dioxygenase activity", "d": ["Catalysis of the reaction: methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789208", "l": "HOCl-induced glycosaminoglycan fragmentation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167130", "l": "Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635666", "l": "esxG:esxH translocates from MTb cytosol to host phagosomal lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097216", "l": "guanosine tetraphosphate binding", "d": ["Binding to guanosine tetraphosphate (5'-ppGpp-3'), a guanosine bisphosphate having diphosphate groups at both the 3' and 5'-positions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35645", "l": "a 2-oxocarboxylate + H(+) + NADH => a (2R)-2-hydroxycarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14302", "l": "4-pyridoxolactone + H2O => 4-pyridoxate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41695", "l": "1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198669", "l": "p38MAPK phosphorylates MSK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624272", "l": "MMPs cleave HB-EGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25949", "l": "a 1,2-diacyl-sn-glycerol + CTP => a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811508", "l": "ING2-bound EP300 acetylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762102", "l": "NICD1 binds the NFE2L2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48338", "l": "a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0032137", "l": "guanine/thymine mispair binding", "d": ["Binding to a double-stranded DNA region containing a G/T mispair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48264", "l": "H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] = H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013438", "l": "RHOD binds effectors at the endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30975", "l": "15-cis-phytoene + 5 A = 5 AH2 + all-trans-3,4-didehydrolycopene", "d": []}, {"i": "EC:1.3.99.30", "l": "\"phytoene desaturase (3,4-didehydrolycopene-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202222", "l": "Phosphorylation of PKC theta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008870", "l": "galactoside O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66954", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP + H(+) => alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140893", "l": "neutral amino acid, sodium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + amino acid(out) + Na+(out) = H+(out) + amino acid(in) + Na+(in)."]}, {"i": "TCDB:2.A.18.6.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19625", "l": "L-threonine = acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445088", "l": "CHL1 interacts with beta1 integrins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63216", "l": "7-cyano-7-carbaguanosine(15) in tRNA + L-lysine = 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73731", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate = (2S,3R,11S)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53854", "l": "7-oxo-glycodeoxycholate + H(+) + NADH => glycocholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004064", "l": "arylesterase activity", "d": ["Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52577", "l": "hexanoyl-CoA + NAD(+) => (2E)-hexenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27382", "l": "(2R)-2,3-bisphosphoglycerate + H2O => (2R)-2-phosphoglycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22237", "l": "2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668558", "l": "NBEA binds PRKAR2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48354", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878117", "l": "RUNX3 binds ZFHX3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202604", "l": "Formation of a heteromeric BMP receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018766", "l": "RHOU binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70281", "l": "D-galactose + raffinose => H2O + stachyose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9626914", "l": "α2-agonists bind ADRA2A,B,C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51975", "l": "an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0098640", "l": "integrin binding involved in cell-matrix adhesion", "d": ["Any integrin binding that occurs as part of the process of cell-matrix adhesion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41471", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625424", "l": "The retrograde IFT train dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174097", "l": "Association of Emi1 with Cdh1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15091", "l": "AH2 + pyruvate => (R)-lactate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982017", "l": "Active G alpha (q) binds RGS proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63910", "l": "ADP + H(+) + phosphate + pravastatin(out) => ATP + H2O + pravastatin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416683", "l": "SEMA3E binds to PLXND1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56211", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] <=> 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17507", "l": "a long-chain fatty acid + ethanolamine => H2O + N-(long-chain fatty acyl)ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54825", "l": "H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] => alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984733", "l": "Kinesin-3 is a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050203", "l": "oxalate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + CoA + oxalate = AMP + diphosphate + H+ + oxalyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671993", "l": "CIT-3 binds DLG4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47458", "l": "3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58166", "l": "7-epi-ent-eudesmane-5,11-diol + diphosphate => (2E,6E)-farnesyl diphosphate + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46851", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) <=> 5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43153", "l": "adenosine(58) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480301", "l": "Expression of EPAS1 (HIF2A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2250301", "l": "Formation of lysyl-pyrrole cross-links (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672170", "l": "SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31952", "l": "9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50466", "l": "17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+) => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12555", "l": "(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> (E)-pinosylvin + 4 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045442", "l": "deacetoxycephalosporin-C hydroxylase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + deacetoxycephalosporin C + O2 = CO2 + deacetylcephalosporin C + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211960", "l": "CYP2U1 19-hydroxylates ARA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21463", "l": "benzoin <=> 2 benzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75901", "l": "1-acyl-sn-glycero-3-phospho-N-acyl-L-serine + a fatty acid + H(+) => 1,2-diacyl-sn-glycero-3-phospho-N-acyl-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47703", "l": "H(+) + ketocytochalasin + NADPH + O2 <=> H2O + iso-precytochalasin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31873", "l": "alpha-seco-amyrin => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210444", "l": "L-Glutamate loading of synaptic vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53937", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 => 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0032934", "l": "sterol binding", "d": ["Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19406", "l": "acetyl-CoA + citrate => (3S)-citryl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58264", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74855", "l": "dopamine + pyruvate = (R)-salsolinol-1-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800298", "l": "HGF dimer binds MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102216", "l": "maltodextrin water dikinase", "d": ["Catalysis of the reaction: ATP + H2O + a maltodextrin = AMP + hydrogenphosphate + a 6-phosphogluco-maltodextrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73757", "l": "Binding of RRN3 to RNA Polymerase I (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112604", "l": "Phosphorylated STATs are released (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19534", "l": "2 H(+) + 2 H2O + N(2)-succinyl-L-arginine => CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17670", "l": "3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 => 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47503", "l": "cholate + NADP(+) <=> 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202731", "l": "JAM3 dimerises (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8979071", "l": "KDM6B binds iron (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855047", "l": "Hydrolysis of internal thioester in C4b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25874", "l": "H2O + pyridine N-oxide => H2O2 + pyridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43906", "l": "all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426489", "l": "RISC binds inexactly matching target RNAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74270", "l": "n H(+)(out) + spermidine(in) <=> n H(+)(in) + spermidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60177", "l": "5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA + H2O => 5-methylaminomethyl-2-selenouridine(34) in tRNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029270", "l": "Recruitment of PLCgamma to membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44902", "l": "D-galactonate + H(+) => D-galactono-1,4-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045549", "l": "9-cis-epoxycarotenoid dioxygenase activity", "d": ["Catalysis of the reactions: a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal; 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al; and 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al."]}, {"i": "EC:1.13.11.51", "l": "\"9-cis-epoxycarotenoid dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56376", "l": "3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 = 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67830", "l": "a lipid A disaccharide + H(+) + UDP => a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032551", "l": "pyrimidine ribonucleoside binding", "d": ["Binding to a pyrimidine ribonucleoside, a compound consisting of a pyrimidine base linked to ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727349", "l": "XDH dehydrogenates xanthine to form urate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24295", "l": "acetyl-CoA + L-glutamate <=> CoA + H(+) + N-acetyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1980125", "l": "ITCH binds DTX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57649", "l": "S-adenosyl-L-methionine + trichosetin => equisetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36677", "l": "CoA + H(+) + N-(octacosanoyl)-sphinganine => octacosanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008688", "l": "3-(3-hydroxyphenyl)propionate hydroxylase activity", "d": ["Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66287", "l": "tomatidine + UDP-alpha-D-glucose <=> H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30572", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine => 6 AMP + 6 diphosphate + enterobactin + 4 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11135", "l": "chlorophyllide a + NADP(+) <=> H(+) + NADPH + protochlorophyllide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68030", "l": "H2O2 + urate => 6,8-dihydroxypurine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29106", "l": "5 H(+)(in) + menaquinone-8 + NADH <=> 4 H(+)(out) + menaquinol-8 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49139", "l": "H(+) + L-methionyl-[protein] + NADPH + O2 <=> H2O + L-methionyl-S-oxide-[protein] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63745", "l": "UDP-alpha-D-glucuronate + zolasartan => UDP + zolarsartan-1-N-beta-D-glucuronide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008386", "l": "cholesterol monooxygenase (side-chain-cleaving) activity", "d": ["Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19408", "l": "acetyl-CoA + citrate <=> (3S)-citryl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60227", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654515", "l": "KAL1 binds HS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21090", "l": "a flavonol + CO2 + H2O + succinate => 2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52183", "l": "(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64736", "l": "4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17948", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58006", "l": "(20S)-ginsenoside Rd + H(+) + UDP => (20S)-ginsenoside F2 + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103069", "l": "17-hydroxyprogesterone 21-hydroxylase activity", "d": ["Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 11-deoxycortisol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18004", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174203", "l": "SCF-mediated degradation of Emi1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36751", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = beta-D-Gal-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.304", "l": "\"UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,4-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29645", "l": "alpha-D-glucose + D-maltohexaose => D-maltoheptaose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45796", "l": "(3R)-3-hydroxybutanoyl-CoA + NADP(+) = acetoacetyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73565", "l": "dGDP(in) + UTP(out) => dGDP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381727", "l": "RAP1A exchanges GDP for GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035885", "l": "exochitinase activity", "d": ["Catalysis of the hydrolysis of terminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, exochitinases progressively cleave off two subunits from the reducing or non-reducing ends of the chitin chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381799", "l": "Synthesis of Preproglucagon in intestinal L cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69140", "l": "RPA binds to the Flap (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12862", "l": "guanosine + H(+) + H2O => NH4(+) + xanthosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24242", "l": "adenosine 5'-phosphosulfate + AH2 => A + AMP + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37361", "l": "D-glucosamine 6-phosphate(in) + L-histidyl-[protein] => D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24553", "l": "5alpha-cholestan-3-one + NADP(+) => cholest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791295", "l": "Aggrecan degradation by MMP1,2,3,7,9,12,13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22915", "l": "L-valine + pyruvate <=> 3-methyl-2-oxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-377640", "l": "Autophosphorylation of SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.21", "l": "\"DNA-3-methyladenine glycosylase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67562", "l": "adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate => 3'-phosphoadenylyl sulfate + taurocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63461", "l": "(2E,6E,10E)-geranylgeraniol + GTP => (2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57754", "l": "C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866269", "l": "ARRB bind GPCRs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203613", "l": "depalmitoylation of eNOS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5252133", "l": "ATP6AP1 binds V-ATPase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15386", "l": "L-asparagine => 3-cyano-L-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29823", "l": "chloride(in) = chloride(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654533", "l": "KRAS4B recycles to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446194", "l": "Addition of a third glucose to the N-glycan precursor by an ALG10 homologue (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26411", "l": "H2O + N-acetyl-D-muramate 6-phosphate => (R)-lactate + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74663", "l": "acetylcholine(in) = acetylcholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106229", "l": "histone glutaryltransferase activity", "d": ["Catalysis of the reaction: glutaryl-CoA + histone = CoA + H+ + N6-glutaryl-histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604360", "l": "Initial activation of proMMP2 by MMP14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034533", "l": "1,2-dihydroxy-7-hydroxymethylnaphthalene dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-7-hydroxymethylnaphthalene + O2 = 2-hydroxy-7-hydroxymethylchromene-2-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26437", "l": "indole + L-serine <=> H2O + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15666", "l": "aldehydo-D-glucose + L-lysyl-[protein] => H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14270", "l": "2 a quinone + H(+) + NADPH => 2 a 1,4-benzosemiquinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013568", "l": "HES5 gene expression is stimulated by NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68409", "l": "(2R,3S)-iso(homo)3citrate + NAD(+) => 2-oxosuberate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16785", "l": "an adenosine in tRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.55", "l": "\"tRNA (adenine-N(6)-)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696547", "l": "STAMBPL1 is a deubiquitinase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11352", "l": "acetate + ATP = acetyl phosphate + ADP", "d": []}, {"i": "EC:2.7.2.1", "l": "\"acetate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8850945", "l": "Casein kinase II phosphorylates PTEN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25795", "l": "ATP + Cu(+)(in) + H2O <=> ADP + Cu(+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047608", "l": "acetylindoxyl oxidase activity", "d": ["Catalysis of the reaction: N-acetylindoxyl + O2 = N-acetylisatin + unknown."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53381", "l": "5,6-dihydrouridine(16) in tRNA + NAD(+) => H(+) + NADH + uridine(16) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607733", "l": "BCL10 binds CARD9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9656893", "l": "OPN1MW binds 11cRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30219", "l": "dimethyl sulfoxide + H2O + NAD(+) = dimethyl sulfone + H(+) + NADH", "d": []}, {"i": "EC:1.8.1.17", "l": "\"dimethylsulfone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39009", "l": "a cholesterol ester(out) => a cholesterol ester(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38410", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052847", "l": "inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity", "d": ["Catalysis of the reaction: 1,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189488", "l": "UROS transforms HMB to URO3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21950", "l": "formate + NH4(+) => formamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9690461", "l": "FKBP1A binds tacrolimus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051722", "l": "protein C-terminal methylesterase activity", "d": ["Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol."]}, {"i": "REACT:R-HSA-8856951", "l": "PP2A demethylation by PPME1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69011", "l": "2 H(+) + L-aspartate + 3 NADPH + 3 O2 <=> 2-nitrobutanedioate + 4 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72329", "l": "3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72509", "l": "2-oxoglutarate(out) + prostaglandin F2alpha(in) => 2-oxoglutarate(in) + prostaglandin F2alpha(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173680", "l": "Activation of C5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36792", "l": "H2O + N(omega)-hydroxy-L-arginine => hydroxyurea + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173542", "l": "SMURF2 ubiquitinates SMAD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14542", "l": "choloyl-CoA + H2O => cholate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61161", "l": "quercetin + UDP-beta-L-rhamnose => H(+) + quercitrin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18513", "l": "D-mannitol + O2 = D-mannose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38993", "l": "1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+) => 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56064", "l": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.2.42", "l": "\"UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24405", "l": "(3S)-hydroxy-3-methylglutaryl-CoA => acetoacetate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32583", "l": "dihydrocarvone + H(+) + NADPH + O2 = 6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52184", "l": "(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25203", "l": "D-arabino-hex-3-ulose 6-phosphate => D-ribulose 5-phosphate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68663", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) 17-sulfate + 3'-phosphoadenylyl sulfate <=> 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) 17-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52282", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate => (6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52345", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036054", "l": "protein-malonyllysine demalonylase activity", "d": ["Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19084", "l": "1-haloalkane + H2O <=> a halide anion + a primary alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54663", "l": "an aromatic (S)-hydroxynitrile <=> an aromatic aldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26323", "l": "3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine => resorcinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13557", "l": "ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.3", "l": "\"glutathione synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33464", "l": "episterol + H(+) + NADPH + O2 => 5-dehydroepisterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30604", "l": "15-cis-phytoene + A => AH2 + all-trans-phytofluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30948", "l": "(2E,6E)-farnesyl diphosphate + H2O => 10-epi-gamma-eudesmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59756", "l": "L-arginine + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.381", "l": "\"arginine N(omega)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183052", "l": "CBL binds to GRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70472", "l": "2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in single-stranded DNA + H2O + O2 => a 2'-deoxycytidine in single-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43110", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide => 2 Fe(III)-[cytochrome c] + H2O + N2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853793", "l": "p-5Y-RET complexes bind GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6795460", "l": "SGK1 phosphorylates MDM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30056", "l": "L-allo-threonine + NADP(+) => (2S)-2-amino-3-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70988", "l": "beta-alanine(out) + n H(+)(in) => beta-alanine(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45900", "l": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17343", "l": "1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH => 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59948", "l": "H2O + prostaglandin F2alpha-CoA = CoA + H(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50540", "l": "prostaglandin A2 = prostaglandin C2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74505", "l": "H2O + NADP(+) + penigequinolone B => H(+) + NADPH + yaequinolone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72563", "l": "butanoate(out) + dehydroepiandrosterone 3-sulfate(in) = butanoate(in) + dehydroepiandrosterone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794058", "l": "NOG binds BMP4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11419", "l": "2 1-O-galloyl-beta-D-glucose <=> 1,6-bis-O-galloyl-beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73817", "l": "3,4-dihydroxybenzaldehyde + 3,5-dihydroxybenzaldehyde => O2 + piceatannol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61182", "l": "H(+) + quercetin 3-O-beta-D-glucoside + UDP => quercetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012597", "l": "GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22866", "l": "D-lysine => L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177479", "l": "Axonal transport of NGF:Trk complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24158", "l": "2-methylpropanoyl phosphate + ADP => 2-methylpropanoate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047789", "l": "creatininase activity", "d": ["Catalysis of the reaction: creatinine + H2O = creatine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14616", "l": "ATP + H2O + taurine(out) <=> ADP + H(+) + phosphate + taurine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19357", "l": "H(+) + L-proline betaine + NADPH + O2 = formaldehyde + H2O + N-methyl-L-proline + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.187", "l": "\"GDP-4-dehydro-D-rhamnose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5604975", "l": "Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BIL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50746", "l": "2 aminomethylphosphonate + 2 glyoxylate + 2 H(+) => 2 glyphosate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0070883", "l": "pre-miRNA binding", "d": ["Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22113", "l": "isoxazolin-5-one + O-acetyl-L-serine => 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42422", "l": "(4R)-4-hydroxy-L-lysine + CO2 + succinate => 2-oxoglutarate + L-lysine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.111", "l": "\"aqualysin 1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11383", "l": "2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2 <=> [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43683", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5229343", "l": "AXIN is phosphorylated in the destruction complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48345", "l": "an N-acyl-sphingoid base + UDP-alpha-D-galactose => a D-galactosylceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17674", "l": "quercetin + S-adenosyl-L-methionine => 3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44703", "l": "a 2,3-saturated acyl-CoA + FAD + H(+) <=> a (2E)-enoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19385", "l": "UDP-alpha-D-glucose + vomilenine = H(+) + raucaffricine + UDP", "d": []}, {"i": "EC:2.4.1.219", "l": "\"vomilenine glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32374", "l": "all-trans-violaxanthin + 2 L-ascorbate <=> all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0016724", "l": "oxidoreductase activity, acting on metal ions, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor."]}, {"i": "EC:1.16.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668218", "l": "NBEA binds DLG3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37754", "l": "2-methyl-trans-aconitate <=> 2-methyl-cis-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33885", "l": "3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH => 2-deoxy-scyllo-inosamine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17561", "l": "acetylcholine + H2O = acetate + choline + H(+)", "d": []}, {"i": "EC:3.1.1.7", "l": "\"acetylcholinesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940007", "l": "MMP13 gene expression is stimulated by RUNX2:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59221", "l": "(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O => (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31831", "l": "(2E,6E)-farnesyl diphosphate = delta-guaiene + diphosphate", "d": []}, {"i": "EC:4.2.3.93", "l": "\"delta-guaiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36264", "l": "hydroxyurea + O-acetyl-L-serine => acetate + H(+) + O-ureido-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56646", "l": "a pseudouridine in mRNA => a uridine in mRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55242", "l": "(9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+) => 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.44", "l": "\"atrolysin E\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55641", "l": "C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate => AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12636", "l": "benzoate + H(+) + NADH + O2 <=> (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683593", "l": "ATG7:ATG3:LC3 dissociates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66095", "l": "3-phenylpyruvate + L-kynurenine <=> H2O + kynurenate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796617", "l": "MIB2 binds CFLAR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008418", "l": "protein-N-terminal asparagine amidohydrolase activity", "d": ["Catalysis of the reaction: N-terminal L-asparaginyl-[protein] + H+ + H2O = N-terminal L-aspartyl-[protein] + NH4+. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014467", "l": "RHOG binds effectors at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203611", "l": "N-myristoylation of eNOS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60313", "l": "L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49091", "l": "FAD + H(+) + H2O + squalene <=> FADH2 + hydroxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031731", "l": "CCR6 chemokine receptor binding", "d": ["Binding to a CCR6 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71857", "l": "taurochenodeoxycholate(in) => taurochenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38882", "l": "a fatty acid(in) <=> a fatty acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103028", "l": "murein hydrolase activity", "d": ["Catalysis of the reaction: a peptidoglycan dimer (generic) = a lipid II + GlcNAc-1,6-anhydro-MurNAc-pentapeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14940", "l": "all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10684", "l": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate", "d": []}, {"i": "EC:3.1.3.48", "l": "\"protein-tyrosine-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953356", "l": "Expression of EXTL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49480", "l": "2 H2O + L-1-piperideine-6-carboxylate + NADP(+) = H(+) + L-2-aminoadipate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72629", "l": "2 H(+)(in) + Zn(2+)(out) => 2 H(+)(out) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404200", "l": "IGF1,2 binds IGF1R (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29599", "l": "monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.125", "l": "\"monacolin L hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371554", "l": "HSF1 acetylation at Lys80 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66688", "l": "4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2 = (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0019118", "l": "phenanthrene-epoxide hydrolase activity", "d": ["Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167113", "l": "Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141437", "l": "Formation of the MCC complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120225", "l": "coenzyme A binding", "d": ["Binding to coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31587", "l": "FMNH2 + NADH + O2 + uracil = (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322434", "l": "XIAP dissociates from ub-TLE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17314", "l": "ATP + L-histidine + tRNA(His) => AMP + diphosphate + H(+) + L-histidyl-tRNA(His)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72548", "l": "2-oxoglutarate(in) + taurocholate(out) => 2-oxoglutarate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43531", "l": "L-serine + NAD(+) <=> 2-aminomalonate semialdehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655760", "l": "Defective SLC40A1 does not transport Fe3+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686578", "l": "Activated ATM phosphorylates ABL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102971", "l": "phosphinothricin N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + phosphinothricin <=> H+ + coenzyme A(4-) + N-acetylphosphinatothricinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28650", "l": "acetophenone + 2 ATP + H2O + hydrogencarbonate <=> 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52071", "l": "9-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31229", "l": "di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP => di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47991", "l": "2-dehydro-3-deoxy-L-galactonate + NAD(+) <=> 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534388", "l": "Progesterone Activation Of CatSper (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683774", "l": "p-T68-CHEK2 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2562564", "l": "Caspase-8 processing within TLR4 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64223", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706328", "l": "Active FLT3 binds to SOCS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390598", "l": "Myosin Binds ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873929", "l": "Casein kinase II phosphorylates STARD10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40833", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694567", "l": "pp1a forms a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28714", "l": "H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) <=> H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139909", "l": "Translocation of BMF to mitochondria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12679", "l": "A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin => AH2 + Latia luciferin + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19848", "l": "nocardicin E + S-adenosyl-L-methionine <=> H(+) + isonocardicin A + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16128", "l": "ATP + D-fructose <=> ADP + D-fructose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1982065", "l": "Ligand-independent dimerization of overexpressed FGFR1b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140449", "l": "centromere-nuclear envelope anchor activity", "d": ["The binding activity of a molecule that brings together the centromeric region of a chromosome and the inner nuclear membrane by interacting with both the centromere/kinetochore complex and the nuclear membrane, in order to establish and maintain the centromere/kinetochore location."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37453", "l": "1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46611", "l": "ATP + L-threonyl-[protein] <=> ADP + H(+) + O-phospho-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48170", "l": "N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate => H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45883", "l": "3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20064", "l": "2'-deoxycytidine + a ribonucleoside 5'-triphosphate <=> a ribonucleoside 5'-diphosphate + dCMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182594", "l": "Association of INK4 family proteins with CDK4/6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791291", "l": "TP53 stimulates BID gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30068", "l": "betaine aldehyde + H2O + NADP(+) => glycine betaine + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675473", "l": "SH2B binds JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749253", "l": "Formation of MCM2-7 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748996", "l": "GST dimers cleave AZA to 6MP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70073", "l": "(22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + sitosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350405", "l": "RHOGEF2 binds to RHO1:GDP complex at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854981", "l": "SHC1 in the RET complex is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60190", "l": "2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70692", "l": "ornithine => putrescine + CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72295", "l": "malate(out) + 3 Na(+)(out) = malate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10849", "l": "an [alpha-factor](in) + ATP + H2O => ADP + an [alpha-factor](out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16595", "l": "3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25717", "l": "H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51088", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52379", "l": "(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) <=> (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25189", "l": "chloroacetate + H2O = chloride + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606839", "l": "Steryl sulfatase hydrolyses sulfate from steroid sulfates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75891", "l": "Abortive Initiation After Second Transition (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54308", "l": "pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41749", "l": "3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => 1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031459", "l": "ABC-type glycine betaine transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in)."]}, {"i": "RHEA:32783", "l": "ATP + glycine betaine(out) + H2O = ADP + glycine betaine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34152", "l": "3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine => 2-deoxystreptamine + 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419843", "l": "CALCA(83-119) binds CALCR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64308", "l": "3-aminobutanoate + pyruvate = acetoacetate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48809", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166175", "l": "TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30200", "l": "2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate => 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21286", "l": "all-trans-retinal + H(+) + NADH => all-trans-retinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72690", "l": "all-trans-retinol(out) <=> all-trans-retinol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29749", "l": "3-phenylpropanoate(out) => 3-phenylpropanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61045", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => (-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20271", "l": "2 5-dehydro-4-deoxy-D-glucuronate => 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25460", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + sibirene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161733", "l": "PGD2 is dehydrated to PGJ2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68457", "l": "(S)-3-hydroxyglutaryl-CoA => (2E)-glutaconyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429497", "l": "SLP-76 stimulates PLC gamma 2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43630", "l": "aminoacetaldehyde + CO2 + NADH => L-serine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.2", "l": "\"ABC-type nonpolar-amino-acid transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.41", "l": "\"polypeptide N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140355", "l": "cargo receptor ligand activity", "d": ["The activity of a gene product that interacts with a cargo receptor and initiates endocytosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64334", "l": "AMP + diphosphate + nicotinyl-CoA => ATP + CoA + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0003989", "l": "acetyl-CoA carboxylase activity", "d": ["Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43798", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607744", "l": "MALT1 binds BCL10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51449", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] => alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25925", "l": "A + H2O + quinolin-8-ol => 8-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28639", "l": "(2Z,6E)-farnesyl diphosphate = (-)-gamma-cadinene + diphosphate", "d": []}, {"i": "EC:4.2.3.62", "l": "\"(-)-gamma-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62765", "l": "4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39249", "l": "(2E,11Z)-eicosadienoyl-CoA + H2O => (3R)-hydroxy-(11Z)-eicosenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69787", "l": "(2-aminophenyl)succinate + succinyl-CoA = 3-(2-aminophenyl)succinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43509", "l": "2,5-diformylfuran + H2O => 2-(dihydroxymethyl)-5-formylfuran", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16232", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) <=> a CDP-1,2-diacyl-sn-glycerol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332236", "l": "CBL neddylates TGFBR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37347", "l": "(R)-lactate + ATP + D-alanine = ADP + D-alanyl-(R)-lactate + phosphate", "d": []}, {"i": "EC:6.1.2.1", "l": "\"D-alanine--(R)-lactate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-179421", "l": "Degradation of multiubiquitinated Nek2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199839", "l": "AKT can phosphorylate RSK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32080", "l": "(13E)-labda-7,13-dien-15-yl diphosphate + H2O => (13E)-labda-7,13-dien-15-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69321", "l": "glucoerucin + H2O => (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051745", "l": "4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity", "d": ["Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+ = isopentenyl diphosphate + NAD(P)+ + H2O. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative name for 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13098", "l": "a (3R)-hydroxyacyl-[ACP] => a (2E)-enoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694583", "l": "ABHD4 hydrolyses NAPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791235", "l": "GADD45A binds AURKA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28501", "l": "formaldehyde + mycothiol <=> S-(hydroxymethyl)mycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52859", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202222", "l": "Phosphorylation of PKC theta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.110", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58223", "l": "L-lysyl-[protein] + NAD(+) <=> H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35497", "l": "4-aminobenzoate + L-glutamate => H2O + N-(4-aminobenzoyl)-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445448", "l": "HHIP binds Hedgehog (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69053", "l": "RFC binding displaces Pol Alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709842", "l": "MAVS binds TOMM70 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30752", "l": "ATP + CoA + hexadecanoate => AMP + diphosphate + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41640", "l": "3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA = 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.41", "l": "\"3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102071", "l": "9,10-epoxy-18-hydroxystearate hydrolase activity", "d": ["Catalysis of the reaction: 9,10-epoxy-18-hydroxystearate + H2O <=> 9,10,18-trihydroxystearate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805059", "l": "CK2:FACT phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2562526", "l": "PLK1 phosphorylates OPTN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681314", "l": "Replication transcription complex binds SARS-CoV-1 genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0050492", "l": "glycerol-1-phosphate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68659", "l": "7-oxocholesterol + H(+) + NADPH <=> 7beta-hydroxycholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665767", "l": "Activated FMNL3 binds G-actin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35067", "l": "(S)-carnitine(out) = (S)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:1902249", "l": "IMP binding", "d": ["Binding to IMP, inosine monophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44755", "l": "2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22278", "l": "a 2-oxocarboxylate + 2 H(+) + NADH => 2-oxoaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39491", "l": "(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21413", "l": "NAD(+) + sn-glycerol 1-phosphate => dihydroxyacetone phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12359", "l": "D-mannose 6-phosphate <=> D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109857", "l": "MAP2K1 binds MAPK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786190", "l": "CMBL hydrolyses OM to OLMS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59691", "l": "D-maltoheptaose + O2 <=> D-maltoheptaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50759", "l": "NADP(+) + reduced [flavodoxin] <=> 2 H(+) + NADPH + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624948", "l": "KIF17 enters the cilium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50437", "l": "prostaglandin H1 => prostaglandin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848812", "l": "HIF1A,EPAS1 bind PTK6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156910", "l": "Formation of eEF1B complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665767", "l": "Activated FMNL3 binds G-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48683", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) <=> a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15397", "l": "dichloromethane + H2O = 2 chloride + formaldehyde + 2 H(+)", "d": []}, {"i": "EC:4.5.1.3", "l": "\"dichloromethane dehalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54461", "l": "1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67658", "l": "2 Fe(II)-[cytochrome c] + H(+) + NADP(+) => 2 Fe(III)-[cytochrome c] + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357483", "l": "RAC1 binds PAK1-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40061", "l": "CoA + decanoate + H(+) => decanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73147", "l": "adenosine 3',5'-bisphosphate(out) + FAD(in) = adenosine 3',5'-bisphosphate(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36788", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine => N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033240", "l": "PEX5L binds PEX7:Cargo protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111966", "l": "GRK2 binds CALM1:4Ca2+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57825", "l": "dAMP + H2O => 2-deoxy-D-ribose 5-phosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377640", "l": "Autophosphorylation of SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201603", "l": "Caspase-mediated cleavage of PKC theta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691004", "l": "XPC binds RAD23 and CETN2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0070026", "l": "nitric oxide binding", "d": ["Binding to nitric oxide (NO)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395517", "l": "NADPH transfers electrons to FDXR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640307", "l": "DeHA hydrolyses to 2,3-DKG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734687", "l": "ORC6 is phosphorylated on T195 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44359", "l": "nogalaviketone <=> methyl nogalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938217", "l": "RUNX1 binds the SWI/SNF complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53142", "l": "H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24198", "l": "(2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+) => (2R,4S)-2,4-diaminopentanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23484", "l": "A + D-cellobiose = AH2 + D-cellobiono-1,5-lactone", "d": []}, {"i": "EC:1.1.99.18", "l": "\"cellobiose dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44015", "l": "(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) <=> (9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000254", "l": "C-4 methylsterol oxidase activity", "d": ["Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H+ + 3 O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111924", "l": "PKA catalytic subunit translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709098", "l": "DHFR dimer reduces FOLA to DHF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928576", "l": "RHOA:GTP binds ROCK, activating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12956", "l": "ATP + L-seryl-[Goodpasture antigen-binding protein] <=> ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382058", "l": "Nck binds to the active PDGF receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0003714", "l": "transcription corepressor activity", "d": ["A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42108", "l": "(20S)-hydroxypregn-4-en-3-one + NAD(+) = H(+) + NADH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0051740", "l": "ethylene binding", "d": ["Binding to ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203611", "l": "N-myristoylation of eNOS (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30027", "l": "D-glyceraldehyde + H(+) + NADH = glycerol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "51.43709390656177", "identifiers": [{"i": "GO:0005261", "l": "monoatomic cation channel activity", "d": ["Enables the energy-independent passage of monoatomic cations across a lipid bilayer down a concentration gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42135", "l": "isonocardicin C <=> nocardicin C", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050346", "l": "trans-L-3-hydroxyproline dehydratase activity", "d": ["Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H2O + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51725", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => adenosine 5'-tetraphosphate + ADP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12418", "l": "acryloyl-CoA + NH4(+) => beta-alanyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634445", "l": "MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022911", "l": "CSPG is secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853801", "l": "PSPN binds RET:GFRA4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39239", "l": "(2E)-triacontenoyl-CoA + H(+) + NADPH = NADP(+) + triacontanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39495", "l": "3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46527", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000399", "l": "RANBP2 SUMOylates SP100 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72162", "l": "glutarate(in) + taurocholate(out) <=> glutarate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215406", "l": "PRMT5 binds WDR77 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9646468", "l": "mTORC1 binds RHEB:GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430190", "l": "p-SLP-76 binds NCK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5618328", "l": "ATAT acetylates microtubules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14422", "l": "H2O + N(2)-benzoyl-D-arginine-4-nitroanilide => 4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47813", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11937", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA => 4 CO2 + 4 CoA + trans-resveratrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21396", "l": "(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) = CO2 + Na(+)(out) + propanoyl-CoA", "d": []}, {"i": "EC:7.2.4.3", "l": "\"(S)-methylmalonyl-CoA decarboxylase (sodium-transporting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.7", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005522", "l": "profilin binding", "d": ["Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43665", "l": "ATP + hydrogencarbonate + tetracosanoyl-CoA => 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668789", "l": "LA,TNFSF14 binds LTBR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74490", "l": "anthranilate + 2 ATP + O-methyl-L-tyrosine + S-adenosyl-L-methionine <=> (-)-4'-methoxycyclopeptine + 2 AMP + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.25", "l": "\"vibriolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694442", "l": "CNIH2,3 bind GRIA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050398", "l": "wax-ester hydrolase activity", "d": ["Catalysis of the reaction: a wax ester + H2O = a long-chain alcohol + a long-chain carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45857", "l": "3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140010", "l": "D-aspartate transmembrane transporter activity", "d": ["Enables the transfer of D-aspartate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20821", "l": "choline sulfate + H2O => choline + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13043", "l": "5,6-dihydroxyindole-2-carboxylate => L-dopachrome", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38912", "l": "avenacoside B + H2O => 26-desgluco-avenacoside B + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9668904", "l": "Formation of the CTF18 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22797", "l": "ATP + D-hamamelose => ADP + D-hamamelose 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51931", "l": "H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) <=> (S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22460", "l": "a 2,3-saturated acyl-CoA + NADP(+) = a 2,3-dehydroacyl-CoA + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.8", "l": "\"acyl-CoA dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59216", "l": "(indol-3-yl)acetate + H(+) = CO2 + skatole", "d": []}, {"i": "EC:4.1.1.115", "l": "\"indoleacetate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046180", "l": "KSPG is secreted from the cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11906", "l": "2,4-dihydroxypteridine + NH4(+) => 2-amino-4-hydroxypteridine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873794", "l": "PCTP binds PC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624131", "l": "UNC119B binds myristoylated proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204813", "l": "Interaction of Tie2 and Grb14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4837364", "l": "Secretion of SOD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848370", "l": "IL18 binds IL18R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37689", "l": "1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71954", "l": "3 Na(+)(out) + sulfate(out) <=> 3 Na(+)(in) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299297", "l": "Activation of THIK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592387", "l": "Fibulin binds elastic fibres (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013438", "l": "RHOD binds effectors at the endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61322", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide => (+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20860", "l": "(1S,6R)-isopiperitenol + NAD(+) = (6R)-isopiperitenone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.223", "l": "\"isopiperitenol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682377", "l": "LC3 de-lipidation by ATG4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23524", "l": "1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol = an alkyl cinnamate + beta-D-glucose", "d": []}, {"i": "EC:2.3.1.152", "l": "\"alcohol O-cinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0036468", "l": "L-dopa decarboxylase activity", "d": ["Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine."]}, {"i": "RHEA:12272", "l": "H(+) + L-dopa = CO2 + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10025", "l": "L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050452", "l": "CoA-glutathione reductase (NADP) activity", "d": ["Catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35316", "l": "H(+) + hexadecanoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111970", "l": "PKC phosphorylates GRK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41646", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate => 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36215", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38405", "l": "(9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+) => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684323", "l": "3CLp forms a homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679045", "l": "C-ter TLR9 dimer binds HCQ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007465", "l": "UXT gene expression is repressed by the PRC1L4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55159", "l": "a quinone + glutathione + H(+) + hydrogen sulfide <=> a quinol + S-sulfanylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53901", "l": "ATP + L-threonyl-[myosin light chain] => ADP + H(+) + O-phospho-L-threonyl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37748", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine => 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710101", "l": "CASP4, CASP5 cleave GSDMD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50723", "l": "FMNH2 + methanesulfinate + O2 <=> FMN + H(+) + H2O + methanesulfonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.22", "l": "\"rRNA N-glycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18138", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) => 5alpha-pregnane-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71867", "l": "glycodeoxycholate(out) = glycodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684008", "l": "NBN binds KPNA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47173", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) => 5alpha-cholest-8-en-3-one + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39690", "l": "(R)-3-hydroxy-(11Z)-octadecenoyl-CoA <=> (2E,11Z)-octadecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.70", "l": "\"pancreatic endopeptidase E\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11943", "l": "2 H(+) + H2O + L-citrulline <=> CO2 + L-ornithine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31492", "l": "soyasaponin III + UDP-beta-L-rhamnose => H(+) + soyasaponin I + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013004", "l": "RHOA binds effectors at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55514", "l": "11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36320", "l": "2 H(+) + 2 NADPH + octadecanoyl-CoA => CoA + 2 NADP(+) + octadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53417", "l": "8-amino-8-demethylriboflavin + S-adenosyl-L-methionine => 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73420", "l": "L-glutamine(out) => L-glutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67139", "l": "3-hydroxypropanoate + ATP + CoA <=> 3-hydroxypropanoyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73054", "l": "hydrogencarbonate(in) + taurocholate(out) <=> hydrogencarbonate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937034", "l": "IRAK1 phosphorylates Pellino (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53314", "l": "16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62872", "l": "(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2 = H2O + NADP(+) + semiviriditoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49914", "l": "(R)-carnitine(in) + O-propanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-propanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204873", "l": "Interaction of Tie2 and Shp2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804762", "l": "TP53 forms homotetramers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50785", "l": "dodecanal + NADP(+) => (2E)-dodecenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13955", "l": "a D-alpha-amino acid + a tRNA + H(+) => a D-aminoacyl-tRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683593", "l": "ATG7:ATG3:LC3 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27498", "l": "3'-O-methyltricetin + S-adenosyl-L-methionine => 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37295", "l": "ATP + H2O + L-alanyl-L-threonine(out) = ADP + H(+) + L-alanyl-L-threonine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050091", "l": "melilotate 3-monooxygenase activity", "d": ["Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + H+ + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52401", "l": "4-O-phospho-D-threonate + NAD(+) => 3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432909", "l": "Interaction of Plectin with Integrin beta 4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21979", "l": "[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite <=> [thioredoxin]-dithiol + adenosine 5'-phosphosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67975", "l": "ATP + ecdysone <=> ADP + ecdysone 22-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33709", "l": "ADP + H(+) + O-phospho-L-threonine => ATP + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19271", "l": "2-furoyl-CoA + AMP + diphosphate => 2-furoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090409", "l": "malonyl-CoA synthetase activity", "d": ["Catalysis of the reaction: malonate + ATP + coenzyme A = malonyl-CoA + AMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49230", "l": "diphosphate + geranylgeranyl-bacteriochlorophyllide a => (2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24153", "l": "adenosine 5'-phosphosulfate + ATP => 3'-phosphoadenylyl sulfate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179402", "l": "Active MMP3 can cleave pro-HBEGF to form active HBEGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445704", "l": "Calcium Binds Caldesmon (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32454", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate <=> all-trans-phytoene + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432143", "l": "PECAM-1 binds PP2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140988", "l": "ADP:inorganic phosphate antiporter activity", "d": ["Enables the transfer of ADP from one side of a membrane to the other according to the reaction: ADP(out) + inorganic phosphate(in) = ADP(in) + inorganic phosphate(out)."]}, {"i": "RHEA:65844", "l": "ADP(out) + H(+)(out) + phosphate(in) = ADP(in) + H(+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754130", "l": "CDK4 inhibitors bind CDK4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59048", "l": "D-ornithine + H(+) = CO2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-167408", "l": "The high affinity receptor complex binds to G-protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9640195", "l": "RRAGA,B hydrolyzes GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218812", "l": "FYN phosphorylates PAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.-", "l": "\"Metallocarboxypeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004566", "l": "beta-glucuronidase activity", "d": ["Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68873", "l": "(E)-cinnamate + ATP + H(+) + NADPH => (E)-cinnamaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419861", "l": "Melanospin is stimulated by light (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15199", "l": "an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69053", "l": "RFC binding displaces Pol Alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982645", "l": "GRKs bind ADRB2:Catecholamine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102732", "l": "myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ATP = H+ + myo-inositol hexakisphosphate(12-) + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46767", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11484", "l": "a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)", "d": []}, {"i": "EC:7.1.1.8", "l": "\"quinol--cytochrome-c reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662986", "l": "MT2A binds copper (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786092", "l": "IL4:IL4R:JAK2 binds IL2RG:JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20808", "l": "acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-7-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395768", "l": "LPL hydrolyses TGs from mature CMs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72002", "l": "O2 + preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + preaspterpenacid acid II", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102193", "l": "protein-ribulosamine 3-kinase activity", "d": ["Catalysis of the reaction: ATP + a [protein]-N6-D-ribulosyl-L-lysine <=> ADP + a [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5591052", "l": "PROCR binds Protein C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102415", "l": "quercetin gentiobioside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-gentiobioside + UDP-alpha-D-glucose <=> quercetin-3-gentiotrioside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14011", "l": "(R,R)-chrysanthemyl diphosphate + diphosphate => 2 dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950684", "l": "Expression of Heterogeneous nuclear ribonucleoprotein D-like (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951951", "l": "RUNX3 binds EP300 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41758", "l": "1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 1-O-methyl-(9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30792", "l": "dGTP + pyruvate => dGDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017045", "l": "corticotropin-releasing hormone activity", "d": ["The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52716", "l": "a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74161", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+) => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50184", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237160", "l": "MTA is cleaved and phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2317314", "l": "AKT binds PDPK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40520", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59443", "l": "(-)-dehydrodiconiferyl alcohol + H(+) + NADPH <=> (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44099", "l": "decan-1-ol + hexadecanoyl-CoA <=> CoA + decanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22631", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate <=> (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26216", "l": "9alpha-copalyl diphosphate + H2O <=> aphidicolan-16beta-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019180", "l": "dTDP-4-amino-4,6-dideoxygalactose transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose = L-glutamate + dTDP-4-dehydro-6-deoxy-D-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139898", "l": "Caspase-8 activates BID by cleavage (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35605", "l": "D-fructose + phosphate => beta-D-fructose 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67304", "l": "3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 = H2O2 + myceliothermophin E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031839", "l": "type 1 neuromedin U receptor binding", "d": ["Binding to a type 1 neuromedin U receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724685", "l": "IgE binds omalizumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420724", "l": "CASR binds Ca2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48943", "l": "an L-aminoacyl-L-amino acid + H2O <=> 2 an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679816", "l": "SIGMAR1 binds dextromethorphan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1852623", "l": "Ubiquitination of NICD1 by FBWX7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005005", "l": "transmembrane-ephrin receptor activity", "d": ["Combining with a transmembrane ephrin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73267", "l": "H(+)(out) + L-methionine(in) = H(+)(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005113", "l": "patched binding", "d": ["Binding to a patched (ptc) protein, a receptor for hedgehog proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18590", "l": "[glutamine synthetase]-L-tyrosine + ATP => [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70257", "l": "cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine => 1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31528", "l": "N(omega)-hydroxy-L-arginine => (S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624956", "l": "PDE6D binds INPP5E (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55502", "l": "ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21921", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9022314", "l": "HIPK2 phosphorylates MECP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74627", "l": "NADPH + 2 O2 + prefumagillin = acetaldehyde + fumagillin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22479", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) <=> 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.46", "l": "\"complement factor D\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42124", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = androsterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73730", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate <=> (2S,3R,11R)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30273", "l": "2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O => 2 (3,4-dimethoxyphenyl)methanol + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33852", "l": "GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) => GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49670", "l": "deoxyviolaceinate + H2O + NAD(+) => H(+) + NADH + O2 + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14867", "l": "H(+) + N-methyltyramine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986258", "l": "SLIT2:ROBO1 binds CXCR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507870", "l": "Aquaporins passively transport water out of cells (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52611", "l": "2-hydroxybutanoate + NADP(+) <=> 2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37265", "l": "ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate => ATP + H2O + L-alanyl-L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65809", "l": "decanoyl-[ACP] + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => dec-9-ynoyl-[ACP] + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786501", "l": "TRMT11:TRMT112 methylates guanosine-10 in tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044102", "l": "purine deoxyribosyltransferase activity", "d": ["Catalysis of deoxyribose exchange between purine deoxyribonucleoside as a donor and purine base as an acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.155", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928597", "l": "EPH:EFN dimers tetramerise (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23374", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11742", "l": "glutathione disulfide + H(+) + NADPH => 2 glutathione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57009", "l": "5,5'-dehydrodivanillate + H(+) + NADH + O2 => 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009385", "l": "N-acylmannosamine-6-phosphate 2-epimerase activity", "d": ["Catalysis of the reaction: N-acetyl-D-mannosamine-6-phosphate = N-acetyl-D-glucosamine-6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9652264", "l": "ERBB2 binds TKIs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.28", "l": "\"secondary-alkyl amine dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381116", "l": "Phosphorylated IRE1 dimer binds ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848023", "l": "Activated PTK6 binds STAP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007882", "l": "IL1F10 is cleaved (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44785", "l": "2-demethylmenaquinol-10 + S-adenosyl-L-methionine => H(+) + menaquinol-10 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373075", "l": "Metabotropic glutamate receptors bind glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27989", "l": "hydroxyacetone + NADP(+) <=> H(+) + methylglyoxal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651773", "l": "LIG1 binds POLB at long-patch BER site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44174", "l": "2 H(+) + NADH + tetradecanoate => H2O + NAD(+) + tetradecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36688", "l": "hexadecanoyl-CoA + sphing-4-enine => CoA + H(+) + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34919", "l": "thiamine(in) = thiamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17800", "l": "[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose <=> [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656215", "l": "RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928615", "l": "EFNBs bind SFKs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59829", "l": "H2O + S-inosyl-L-homocysteine => inosine + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198813", "l": "GSTO dimers reduce DeHA to AscH- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75648", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (8R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45259", "l": "hexadecanoate(out) <=> hexadecanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36753", "l": "beta-D-Gal-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41825", "l": "3-oxohexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyhexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.5", "l": "\"cathepsin D\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264615", "l": "Loading of acetylcholine in synaptic vesicles (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432455", "l": "Nuclear PER is degraded by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047731", "l": "catechol oxidase (dimerizing) activity", "d": ["Catalysis of the reaction: 4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49748", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate = CO2 + 2 H2O + NADP(+) + proviolacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15260", "l": "D-threonine <=> acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30030", "l": "D-glyceraldehyde + H(+) + NADH <=> glycerol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74393", "l": "methylamine(in) => methylamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12407", "l": "D-glucose + UDP-alpha-D-galactose <=> H(+) + lactose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647977", "l": "ICMT methylates S-Farn RAS proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55358", "l": "13-cis-retinol => 11-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102185", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NADH(2-) + O2 + H+ <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388503", "l": "Oxytocin receptor bind oxytocin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68481", "l": "(2R)-2-hydroperoxyhexadecanoate + H(+) => CO2 + H2O + pentadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51276", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50672", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O = [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53396", "l": "a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48417", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)) => CMP + ganglioside GM2 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24222", "l": "(4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29143", "l": "a ubiquinol + 2 H(+)(in) + nitrate = a ubiquinone + 2 H(+)(out) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58902", "l": "NH4(+) + urea-1,3-dicarboxylate => 1-carboxybiuret + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13874", "l": "(+)-copalyl diphosphate => abieta-7,13-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50332", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20800", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.1", "l": "\"DNA ligase (ATP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39008", "l": "a cholesterol ester(in) => a cholesterol ester(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799350", "l": "Exocytosis of specific granule membrane proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44322", "l": "decanoate + glycerol + H(+) => 1-decanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654569", "l": "Activated FGFR1 binds FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18704", "l": "arsenite + H2O + 2 oxidized [azurin] <=> arsenate + 3 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21292", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.153", "l": "\"phosphatidylinositol-4,5-bisphosphate 3-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22513", "l": "3 H(+) + precorrin-8X => hydrogenobyrinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38763", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875523", "l": "MET binds TNS3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56256", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800793", "l": "PIDD1 translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793485", "l": "PRKN polyubiquitinates RIPK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362386", "l": "Glycosylation of Hh (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60369", "l": "urate(out) => urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043823", "l": "spheroidene monooxygenase activity", "d": ["Catalysis of the reaction: spheroidene + O2 = spheroidenone + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11057", "l": "4-aminobenzoate + 2 H(+) + NADPH + O2 => 4-aminophenol + CO2 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52822", "l": "CoA + O-succinyl-L-serine => L-serine + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55952", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22701", "l": "gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase] => gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211715", "l": "Proteasome mediated degradation of PAK-2p34 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110215", "l": "Cleavage of uracil by UNG glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418858", "l": "RhoGTPase GEF's recruited to DCC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051670", "l": "inulinase activity", "d": ["Catalysis of the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57821", "l": "[phosphate](n) + ADP => [phosphate](n+1) + AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102771", "l": "sphingolipid very long chain fatty acid alpha-hydroxylase activity", "d": ["Catalysis of the reaction: O2 + NADPH + H+ + a dihydroceramide = NADP + H2O + an alpha hydroxydihydroceramide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50169", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39422", "l": "3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759731", "l": "SNAI1 binds the OCLN gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15002", "l": "keto-L-sorbose + NADP(+) => 5-dehydro-D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705584", "l": "HMGCR dimer binds statins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701147", "l": "TRPV1 binds TRPV1 blockers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674095", "l": "PDGFRs bind type II TKI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40967", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65260", "l": "verruculide C epoxide = 3-hydroxypentacecilide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "59.581836007040643", "identifiers": [{"i": "GO:0016616", "l": "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391158", "l": "SIRP alpha binds CD47 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11575", "l": "FAD + H(+) + H2O + lithocholate <=> chenodeoxycholate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647680", "l": "CASP1 cleaves GSDMD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-202164", "l": "Translocation of PDK1 to Plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41040", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848124", "l": "PTK6 phosphorylates STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46113", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41939", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798374", "l": "DYRK2 phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35579", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8 = anthocyanin A11 + D-glucose", "d": []}, {"i": "EC:2.3.1.n12", "l": "\"sinapoyl-beta-D-glucose:anthocyanin sinapoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22516", "l": "ATP + taurocyamine = ADP + H(+) + N-phosphotaurocyamine", "d": []}, {"i": "EC:2.7.3.4", "l": "\"taurocyamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40866", "l": "FAD + H(+) + heptadecanoyl-CoA <=> FADH2 + trans-2-heptadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605624", "l": "Beta-galactosidase hydrolyses GM1 to GM2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202174", "l": "Activation of ZAP-70 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696980", "l": "Spike trimer glycoside chains get additional branches (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015224", "l": "biopterin transmembrane transporter activity", "d": ["Enables the transfer of biopterin from one side of a membrane to the other. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39171", "l": "3-oxoeicosanoyl-CoA + H(+) + NADPH = (3R)-hydroxyeicosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193703", "l": "IKKbeta is activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36308", "l": "(E)-caffeoyl-CoA + H2O => 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40617", "l": "2,3-didecanoyl-sn-glycerol + decanoate + H(+) => H2O + tridecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30584", "l": "2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide => 2-demethylmenaquinone-8 + H2O + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062060", "l": "NuA4 histone acetyltransferase complex binding", "d": ["Binding to a NuA4 histone acetyltransferase complex."]}]}
{"type": "biolink:MolecularActivity", "ic": "77.264511229695032", "identifiers": [{"i": "GO:0015923", "l": "mannosidase activity", "d": ["Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046408", "l": "chlorophyll synthetase activity", "d": ["Catalysis of the reaction: chlorophyllide a + 2 H+ + phytyl diphosphate = chlorophyll a + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72091", "l": "(R)-carnitine(out) + Na(+)(out) = (R)-carnitine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9010815", "l": "SLITs bind keratan sulfate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75966", "l": "15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione <=> 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204949", "l": "NRIF and TRAF6 may activate JNK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37253", "l": "cysteamine + phosphate => cysteamine S-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28351", "l": "UDP-beta-L-arabinofuranose => UDP-beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62913", "l": "H(+) + NADH + O2 + toralactone => 1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18097", "l": "pteridine-2,4,6,7-tetrol = H(+) + xanthine-8-carboxylate", "d": []}, {"i": "EC:5.5.1.3", "l": "\"tetrahydroxypteridine cycloisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44940", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O = 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9726621", "l": "PGR binds PGR antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71993", "l": "(-)-astellatene + diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404144", "l": "Parenchymal atROL translocates to HSCs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11645", "l": "a (2R,3R)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70768", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444433", "l": "Cho transports from the extracellular space to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.12", "l": "\"linoleate 13S-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36510", "l": "docosanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxotetracosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74903", "l": "(2E)-2-butenoate + ATP + H(+) = (2E)-but-2-enoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33589", "l": "CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0019238", "l": "cyclohydrolase activity", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684052", "l": "PIAS4 SUMOylates MDC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57202", "l": "N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] => glyoxal + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48767", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) <=> 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36155", "l": "AH2 + Co(II)-factor III + S-adenosyl-L-methionine = A + Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.272", "l": "\"cobalt-factor III methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64419", "l": "D-xylofuranose + NADP(+) <=> D-xylono-1,4-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.1", "l": "\"asparaginase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41411", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102688", "l": "dihydrozeatin UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + dihydrozeatin <=> H+ + 9-(alpha-D-glucosyl)dihydrozeatin + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047355", "l": "CDP-glycerol glycerophosphotransferase activity", "d": ["Catalysis of the reaction: glycerophosphate(n) + CDP-glycerol = glycerophosphate(n+1) + CMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694421", "l": "PP6 dephosphorylates SEC24 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16934", "l": "1-aminocyclopropane-1-carboxylate + H2O => 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19410", "l": "cholate + NAD(+) => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37616", "l": "(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59579", "l": "anserine + H2O <=> beta-alanine + N(pros)-methyl-L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54035", "l": "(6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose <=> (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32352", "l": "3 S-adenosyl-L-methionine + tricetin => 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70445", "l": "a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849055", "l": "PTK6 binds ARHGAP35 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11132", "l": "chlorophyllide a + NADP(+) = H(+) + NADPH + protochlorophyllide a", "d": []}, {"i": "EC:1.3.1.33", "l": "\"protochlorophyllide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322429", "l": "XIAP monoubiquinates TLE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55392", "l": "an adenosine in mRNA + S-adenosyl-L-methionine = an N(1)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20708", "l": "ATP + erythritol = ADP + D-erythritol 4-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.27", "l": "\"erythritol kinase (D-erythritol 4-phosphate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40498", "l": "N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2 <=> N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53633", "l": "(2E,6E)-farnesyl diphosphate => (3S)-(+)-asterisca-2(9),6-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24437", "l": "H2 + methanophenazine => dihydromethanophenazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177937", "l": "Phosphorylation of EGFR by SRC kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5334827", "l": "SUMO-CRABP2 binds atRA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0099510", "l": "calcium ion binding involved in regulation of cytosolic calcium ion concentration", "d": ["The directed change of cytosolic calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in cytosolic calcium concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800798", "l": "The PIDDosome binds CASP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70892", "l": "L-asparagine(out) + L-glutamine(in) + Na(+)(out) => L-asparagine(in) + L-glutamine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39211", "l": "(3R)-hydroxyhexacosanoyl-CoA = (2E)-hexacosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41386", "l": "H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23208", "l": "acetyl-CoA + trans-glutaconate = (2E)-glutaconyl-CoA + acetate", "d": []}, {"i": "EC:2.8.3.12", "l": "\"glutaconate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52072", "l": "12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9726509", "l": "NR3C2 binds fludrocortisone (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031749", "l": "D2 dopamine receptor binding", "d": ["Binding to a D2 dopamine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5334794", "l": "FABPs bind LCFAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196929", "l": "FLAD1 phosphorylates FMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389350", "l": "Activation of Cdc42 by pVav1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22584", "l": "2 H(+) + heme b = Fe(2+) + protoporphyrin IX", "d": []}, {"i": "EC:4.98.1.1", "l": "\"protoporphyrin ferrochelatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28541", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) <=> ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53681", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 => 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40601", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730899", "l": "Oligomerization of BCL10 and MALT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63498", "l": "4-nitrobenzyl alcohol + NADP(+) => 4-nitrobenzaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39887", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43247", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10083", "l": "dihydrophloroglucinol + NADP(+) <=> 1,3,5-trihydroxybenzene + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47985", "l": "H2O + presqualene diphosphate => diphosphate + hydroxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11944", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O = 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39691", "l": "(2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH = (11Z)-octadecenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-434650", "l": "MATEs mediate extrusion of xenobiotics (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031762", "l": "follicle-stimulating hormone receptor binding", "d": ["Binding to a follicle-stimulating hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75584", "l": "11-O-acetylcyathatriol + UDP-alpha-D-xylose => erinacine Q + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211951", "l": "CYP1B1 4-hydroxylates EST17b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47300", "l": "(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50904", "l": "L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953037", "l": "E2F8 forms homodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27445", "l": "NADP(+) + xylitol = D-xylose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975188", "l": "TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42126", "l": "androsterone + H(+) + NADH => 5alpha-androstane-3alpha,17beta-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51509", "l": "2-oxoglutarate + L-proline + O2 => CO2 + succinate + trans-4-hydroxy-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19658", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) => CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22116", "l": "luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP", "d": []}, {"i": "EC:2.4.1.191", "l": "\"luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804527", "l": "INTL1 binds bacterial glycans (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047241", "l": "lipopolysaccharide N-acetylmannosaminouronosyltransferase activity", "d": ["Catalysis of the reaction: lipopolysaccharide + UDP-N-acetylmannosaminouronate = N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54022", "l": "CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein] => L-lysyl-[protein] + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102843", "l": "1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity (SN2-16:1 forming)", "d": ["Catalysis of the reaction: 1-18:2-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161659", "l": "PGE2 is dehydrated to PGA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983158", "l": "Trimming of peptides in ER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849102", "l": "SRMS phosphorylates PTK6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.64", "l": "\"retinoid isomerohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64882", "l": "CMP + H(+) + phosphate => CDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70704", "l": "D-cycloserine(in) + H(+)(in) => D-cycloserine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75858", "l": "9-cis-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-cis-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59374", "l": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+) => 1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26452", "l": "H(+) + NADPH + succinyl-CoA => CoA + NADP(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604834", "l": "SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5604929", "l": "Activated protein C binds Protein S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21248", "l": "a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675790", "l": "MTORC1 dissociates from ULK complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41829", "l": "(3R)-hydroxyhexanoyl-[ACP] => (2E)-hexenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41771", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) <=> CMP + ganglioside GT1a (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10500", "l": "butanoyl-CoA + glyoxylate + H2O = 3-ethylmalate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.7", "l": "\"3-ethylmalate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43507", "l": "5-hydroxymethylfurfural + O2 <=> 2,5-diformylfuran + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36921", "l": "3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA => (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211968", "l": "CYP2W1 oxidises INDOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0090434", "l": "oleoyl-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + oleic acid + CoA = AMP + diphosphate + oleoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12284", "l": "3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-hydroxy-3-methylglutaryl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75378", "l": "inosine(in) <=> inosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667965", "l": "ANKLE2 binds PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47894", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139899", "l": "Sequestration of BAD protein by 14-3-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73452", "l": "adenosine 3',5'-bisphosphate(in) + AMP(out) => adenosine 3',5'-bisphosphate(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38893", "l": "hexadecanoate + sphing-4-enine => H2O + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17143", "l": "glyoxylate + L-aspartate => glycine + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166214", "l": "FA anion flip-flops to the opposite surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67655", "l": "dADP + H2O <=> 2'-deoxyadenosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58916", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + squalene = (S)-2,3-epoxysqualene + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37031", "l": "D-ribonate = 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34131", "l": "neryl diphosphate + olivetolate = cannabinerolate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71154", "l": "4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one <=> (E)-caffeoylpyruvate + CO2 + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42006", "l": "17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH => 5alpha-androstane-3alpha,17beta-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45398", "l": "(9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71303", "l": "RPE dimers isomerise RU5P to XY5P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856945", "l": "PP2A methylation by LCMT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40820", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71854", "l": "glycocholate(out) <=> glycocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18996", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419861", "l": "Melanospin is stimulated by light (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38703", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10722", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione => 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794008", "l": "LUBAC binds CFLAR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71059", "l": "L-arginine(in) + L-leucine(out) = L-arginine(out) + L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39187", "l": "(3R)-hydroxydocosanoyl-CoA = (2E)-docosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46772", "l": "1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.28", "l": "\"sn-1 stearoyl-lipid 9-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10255", "l": "H(+) + hydrogen sulfide + O-phospho-L-serine <=> L-cysteine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655289", "l": "Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24804", "l": "2-oxoglutarate + L-isoleucine <=> (S)-3-methyl-2-oxopentanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011543", "l": "DCA binds PDK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16647", "l": "CoA + H(+) + hexadecanoate => H2O + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64916", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29671", "l": "Ca(2+)(in) = Ca(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607746", "l": "PKC-delta is activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23204", "l": "chlorogenate + D-glucarate = 2-O-caffeoylglucarate + L-quinate", "d": []}, {"i": "EC:2.3.1.98", "l": "\"chlorogenate--glucarate O-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000825", "l": "inositol tetrakisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852200", "l": "Inactivation of LCK by PTPN22 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11525", "l": "5beta-cholestan-3-one + NADP(+) => cholest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390595", "l": "Calcium Binds Troponin-C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25268", "l": "2-phenylethylamine + H2O + O2 <=> 2-phenylacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72734", "l": "UDP-alpha-D-glucose(in) + UMP(out) <=> UDP-alpha-D-glucose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019177", "l": "dihydroneopterin triphosphate pyrophosphohydrolase activity", "d": ["Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69277", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate => but-3-enenitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72949", "l": "acetate(in) + 2 Na(+)(in) => acetate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202510", "l": "Activation of TAK1-TAB2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48750", "l": "D-erythrulose + H(+) + NADH => D-threitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63431", "l": "ATP + H2O + levoglucosan <=> ADP + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12697", "l": "ATP + dGMP = ADP + dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070539", "l": "linoleic acid binding", "d": ["Binding to linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679028", "l": "JAK3 binds JAK3 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49979", "l": "butanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38996", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O => a 1-acyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74612", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-glucosamine(out) => UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-glucosamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876868", "l": "ECE1 cleaves EDN1(53-90) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605717", "l": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592238", "l": "Expression of ALAS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15668", "l": "aldehydo-D-glucose + L-lysyl-[protein] <=> H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653974", "l": "Ragulator binds Rag dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622579", "l": "FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31792", "l": "H2O + tuberculosinyl diphosphate => (13S)-edaxadiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0004370", "l": "glycerol kinase activity", "d": ["Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66152", "l": "acetyl-CoA + noradrenaline = CoA + H(+) + N-acetylnoradrenaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46798", "l": "an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67534", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine => (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71344", "l": "chloride(out) + L-histidine(out) + 2 Na(+)(out) => chloride(in) + L-histidine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2167942", "l": "Collagen type XIII ectodomain shedding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70596", "l": "GOT2 dimer deaminates L-Asp (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24496", "l": "4-O-deacetylvindoline + acetyl-CoA = CoA + vindoline", "d": []}, {"i": "EC:2.3.1.107", "l": "\"deacetylvindoline O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174445", "l": "RPA binds to the Flap on the C-strand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755304", "l": "MUL1 ubiquitinates UBXN7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043818", "l": "precorrin-3B synthase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + precorrin-3A = H2O + NAD+ + precorrin-3B."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694794", "l": "mRNA3 is translated to protein 3a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34036", "l": "O2 + paromamine => 6'-oxoparomamine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12667", "l": "an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+) => a 2-deoxystreptamine antibiotic + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73945", "l": "griseofulvin + NADP(+) => dehydrogriseofulvin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429955", "l": "CCR4-NOT complex deadenylates mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950623", "l": "Expression of Carbonic anhydrase 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008726", "l": "alkanesulfonate monooxygenase activity", "d": ["Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71590", "l": "(S)-malate(in) + 2-oxoglutarate(out) <=> (S)-malate(out) + 2-oxoglutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41371", "l": "1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210282", "l": "Interaction of GPVI and FceRI gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209377", "l": "Polymeric PGN binds to PGRP-LCx at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015437", "l": "lipopolysaccharide floppase activity", "d": ["Enables the transfer of a lipopolysaccharide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2400010", "l": "AKT inhibitors block AKT membrane recruitment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50412", "l": "L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] = H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709831", "l": "HSP90 binds TBK1 and IRF3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38254", "l": "hexadecan-1-ol + octadecanoyl-CoA <=> CoA + hexadecanyl octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43897", "l": "3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849900", "l": "SALMs1-3 bind each other in cis interactions (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11984", "l": "AH2 + O2 + progesterone = A + H2O + testosterone acetate", "d": []}, {"i": "EC:1.14.99.4", "l": "\"progesterone monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57788", "l": "1,3-dinitrobenzene + NADH + O2 = 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19086", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53978", "l": "(14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31896", "l": "(2E,6E)-farnesyl diphosphate => alpha-humulene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57141", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54951", "l": "(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] <=> (2E,5Z)-dodecadienoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11322", "l": "UDP-alpha-D-xylose => UDP-beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782879", "l": "TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168376", "l": "STIM1 oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67016", "l": "a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30977", "l": "5 AH2 + all-trans-3,4-didehydrolycopene => 15-cis-phytoene + 5 A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444208", "l": "MLNR (GPR38) is a receptor for motilin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27532", "l": "(3S,6E)-nerolidol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51766", "l": "4-prenylphlorisovalerophenone + diphosphate => dimethylallyl diphosphate + phlorisovalerophenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352059", "l": "SLC6A15-mediated amino acid uptake (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061579", "l": "N-acyl homoserine lactone synthase activity", "d": ["Catalyzing the reaction: acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine -> [acyl-carrier- protein] + S-methyl-5'-thioadenosine + N-acyl-L-homoserine lactone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462005", "l": "pro-defensin alpha 5 is secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004590", "l": "orotidine-5'-phosphate decarboxylase activity", "d": ["Catalysis of the reaction: H+ + orotidine 5'-phosphate = CO2 + UMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9604308", "l": "NICD4 traffics to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938965", "l": "RUNX1 and ELF1, ELF2 or PAX5 bind the BLK gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42530", "l": "pseudouridine(955/2504/2580) in 23S rRNA => uridine(955/2504/2580) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42348", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622310", "l": "Activated NOD1 oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65405", "l": "butan-1-ol + hexanoyl-CoA => butyl hexanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63605", "l": "[Pyr1]apelin-13 + H2O => [Pyr1]apelin-12 + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35003", "l": "L-fucose(in) = L-fucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296043", "l": "Activation of HCN channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050582", "l": "xylitol oxidase activity", "d": ["Catalysis of the reaction: xylitol + O2 = xylose + H2O2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047918", "l": "GDP-mannose 3,5-epimerase activity", "d": ["Catalysis of the reaction: GDP-mannose = GDP-L-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68881", "l": "ATP + H(+) + NADPH + salicylate => AMP + diphosphate + NADP(+) + salicylaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102825", "l": "quercetin 3-O-rhamnoside-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose(2-) + quercetin 3-O-rhamnoside <=> quercetin 3-O-rhamnoside-7-O-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50863", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030395", "l": "lactose binding", "d": ["Binding to lactose, a disaccharide of glucose and galactose, the carbohydrate of milk."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35527", "l": "H(+) + N-ethylmaleimide + NADH = N-ethylsuccinimide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72815", "l": "L-lysine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) = L-lysine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17597", "l": "D-mannitol + 2 Fe(III)-[cytochrome c] = D-fructose + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}, {"i": "EC:1.1.2.2", "l": "\"mannitol dehydrogenase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11650", "l": "1,4-menthane-3,8-diol + H2O + NADP(+) => (-)-menthol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64359", "l": "2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 <=> (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51380", "l": "(9Z)-octadecenoyl-CoA + dopamine = CoA + H(+) + N-(9Z-octadecanoyl)-dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625841", "l": "Defective SLC24A1 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23708", "l": "[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)", "d": []}, {"i": "EC:2.4.1.129", "l": "\"peptidoglycan glycosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944236", "l": "Association of procollagen type XIV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868071", "l": "Clathrin recruits PIK3C2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448744", "l": "IL20RA binds IL20RB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090655", "l": "double-stranded/single-stranded junction telomeric DNA binding", "d": ["Binding to a junction formed at the point where double-stranded telomeric DNA becomes a single-stranded G-rich telomeric DNA 3' overhang."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42610", "l": "a plastoquinol + n H(+)(out) + NAD(+) => a plastoquinone + (n+1) H(+)(in) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990439", "l": "MAP kinase serine/threonine phosphatase activity", "d": ["Catalysis of the reaction: MAP kinase threonine phosphate + H2O = MAP kinase threonine + phosphate and MAP kinase serine phosphate + H2O = MAP kinase serine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9005980", "l": "IL21 binds IL21R:JAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59256", "l": "Fe(III)-enterobactin + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114560", "l": "Adhesion of integrin alphaIIbbeta3 to fibrin network (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75583", "l": "11-O-acetylcyathatriol + UDP-alpha-D-xylose = erinacine Q + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56447", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57689", "l": "apo-[corrinoid adenosyltransferase] + cob(II)inamide => cob(II)inamide-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63419", "l": "2,6-dichlorohydroquinone + FADH2 + O2 <=> 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39586", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55140", "l": "D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] = AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047459", "l": "3-aminobutyryl-CoA ammonia-lyase activity", "d": ["Catalysis of the reaction: (S)-3-aminobutanoyl-CoA = crotonoyl-CoA + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25078", "l": "(2S)-2-isopropyl-3-oxosuccinate + H(+) = 4-methyl-2-oxopentanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430201", "l": "p-SLP-76:ADAP binds Ena/VASP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033408", "l": "UCG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UCG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65185", "l": "2-oxoglutarate + O2 + preaustinoid A1 => berkeleyone B + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16481", "l": "3 S-adenosyl-L-methionine = 3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.43", "l": "\"nicotianamine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374680", "l": "L1 trans-homophilic interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675198", "l": "Activated MAPKs phosphorylate BRAF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10610", "l": "(E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103004", "l": "9,10-epoxystearate hydroxylase activity", "d": ["Catalysis of the reaction: H+ + 9,10-epoxystearate + O2 + NADPH <=> 9,10-epoxy-18-hydroxystearate + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467716", "l": "AGRN binds Alpha-dystroglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398184", "l": "LARG activation by G alpha 12/13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618405", "l": "ARL4C mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140616", "l": "iodotyrosine deiodinase activity", "d": ["Catalyzes the reaction: 2 iodide + L-tyrosine + 2 NADP+ = 3,5-diiodo-L-tyrosine + H+ + 2 NADPH. Note that this activity has only been demonstrated in the direction of 3-deiodination. 3-bromo-L-tyrosine and 3-chloro-L-tyrosine can also be used as substrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641147", "l": "DACT1 binds DVL2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10428", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}, {"i": "EC:1.13.11.31", "l": "\"arachidonate 12-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694341", "l": "Spike protein gets palmitoylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33678", "l": "H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) <=> H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27688", "l": "ADP + GTP => ATP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043720", "l": "3-keto-5-aminohexanoate cleavage activity", "d": ["Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112342", "l": "Inactivation of MAP2K1 by CDK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66868", "l": "3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28362", "l": "dGTP + H2O = dGMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23199", "l": "3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine <=> 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389532", "l": "PP2A binds CTLA4 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53173", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655263", "l": "Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653957", "l": "Rag dimer formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39618", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA <=> (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24444", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}, {"i": "EC:2.4.1.214", "l": "\"glycoprotein 3-alpha-L-fucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62560", "l": "(4R)-limonene + A + H2O = (4R)-perillyl alcohol + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41354", "l": "a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60346", "l": "H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine => L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047829", "l": "D-nopaline dehydrogenase activity", "d": ["Catalysis of the reaction: N2-(D-1,3-dicarboxypropyl)-L-arginine + NADP+ + H2O = L-arginine + 2-oxoglutarate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69053", "l": "RFC binding displaces Pol Alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046917", "l": "triphosphoribosyl-dephospho-CoA synthase activity", "d": ["Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112435", "l": "Formation of Elongin BC complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45188", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653957", "l": "Rag dimer formation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21704", "l": "H2O + L-tyrosine = NH4(+) + phenol + pyruvate", "d": []}, {"i": "EC:4.1.99.2", "l": "\"tyrosine phenol-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15403", "l": "a dolichyl beta-D-glucosyl phosphate + UDP => a dolichyl phosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44132", "l": "2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.128", "l": "\"N(4)-bis(aminopropyl)spermidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.65", "l": "\"thermomycolin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418091", "l": "F2R binds ARRB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75012", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate => 9-(9Z-octadecenoyloxy)-octadecanoate + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33619", "l": "ATP + CoA + tetradecanoate = AMP + diphosphate + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75106", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371582", "l": "HSBP1 binds HSF1 trimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750666", "l": "ALB binds ST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70432", "l": "2 H(+)(out) + Li(+)(in) => 2 H(+)(in) + Li(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14681", "l": "2 2-aminophenol + A + O2 = 2-aminophenoxazin-3-one + AH2 + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16373", "l": "(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.33", "l": "\"pantothenate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31175", "l": "(2E)-2-methylpropenoyl-CoA + H2O = (S)-3-hydroxyisobutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73198", "l": "malonate(in) + sulfate(out) <=> malonate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052774", "l": "glucosyl-N-acetylglucosamine glucosaminidase activity", "d": ["Catalysis of the reaction: glucosyl-N-acetylglucosamine + H2O = glucosamine + N-acetylglucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12458", "l": "CDP-L-ribitol + diphosphate => CTP + D-ribitol 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381608", "l": "cAMP activates EPAC2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39448", "l": "(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20058", "l": "2 H(+) + H2O + N-carbamoylsarcosine => CO2 + NH4(+) + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66378", "l": "D-erythrose + phosphate => D-erythrose 4-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70224", "l": "(2S)-2-aminobutanoate + 2-oxoglutarate => 2-oxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69042", "l": "2-nitrobutanedioate + H2O + NADP(+) => (2S)-2-nitrosobutanedioate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68996", "l": "2-oxoglutarate + gibberellin A9 + O2 = CO2 + gibberellin A4 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357828", "l": "RIPK1 is cleaved by CASP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939204", "l": "ESTG binds ESR1:chaperone complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44163", "l": "1D-myo-inositol 6-phosphate + H2O <=> myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9680443", "l": "ROCK1,2 bind ROCKi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265177", "l": "Exocyst complex formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167136", "l": "Addition of nucleotides 5 through 9 on the growing HIV-1 transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55820", "l": "a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42948", "l": "cytidine(48) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607721", "l": "Activation of NIK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.35", "l": "\"(R)-2-methylmalate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15482", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O => (6S)-5,6,7,8-tetrahydrofolate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47394", "l": "an aliphatic alcohol + H(+) + hexadecanoate => H2O + hexadecanoate ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68148", "l": "2-octanone + H(+) + NADPH = (2R)-octan-2-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24199", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) <=> (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.55", "l": "\"E1 SAMP-activating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627369", "l": "SEPT4 binds XIAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48658", "l": "5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12587", "l": "16alpha-hydroxyprogesterone <=> 16,17-didehydroprogesterone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696131", "l": "AOC1 deaminates Hist (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42960", "l": "H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain] = NADH + 2 oxidized [nitric oxide reductase rubredoxin domain]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033149", "l": "FFAT motif binding", "d": ["Binding to a FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14231", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10326", "l": "a 2-hydroxycarbonyl + H(+) + NADPH => an L-glycol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41628", "l": "geranylgeranyl diphosphate + H2O = cyclooctat-9-en-7-ol + diphosphate", "d": []}, {"i": "EC:4.2.3.146", "l": "\"cyclooctat-9-en-7-ol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73196", "l": "malonate(in) + sulfate(out) => malonate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34502", "l": "1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] <=> H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30580", "l": "H2O + O-phospho-L-threonine => L-threonine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19879", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35871", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102508", "l": "cyanidin 3,7-diglucoside glucosidase activity", "d": ["Catalysis of the reaction: cyanidin 3,7-di-O-beta-D-glucoside betaine + H2O <=> cyanidin 3-O-beta-D-glucoside betaine + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449087", "l": "CD4 binds Interleukin-16 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51075", "l": "a phenol + an aryl sulfate <=> a phenol + an aryl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866851", "l": "CFTR transits to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41869", "l": "decanoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75334", "l": "chloride(out) + D-methionine(out) + 2 Na(+)(out) <=> chloride(in) + D-methionine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46990", "l": "6-hydroxy-N-methylmyosmine + H2O2 => (R)-6-hydroxynicotine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38028", "l": "(E)-caffeate + hydrocaffeoyl-CoA => (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018609", "l": "chlorobenzene dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-unsubstituted benzenoid + O2 + NAD(P)H + H+ = 2,3-cis-dihydroxydihydrobenzenoid + NAD(P)+. Substrates include 1,4-dichlorobenzene (forms 3,6-dichloro-cis-1,2-dihydroxycyclohexa-3,5-diene), 1,2,3,4-tetrachlorobenzene (forms cis-chlorobenzene dihydrodiol) and 1,2,4-trichlorobenzene (forms 3,4,6-trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27396", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 <=> dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851933", "l": "MET phosphorylates GAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013143", "l": "RAC1 GEFs activate RAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35776", "l": "L-glutamine + UDP-3-oxo-alpha-D-glucose => 2-oxoglutaramate + UDP-alpha-D-kanosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12941", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}, {"i": "EC:2.4.1.143", "l": "\"alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10801", "l": "diphosphate + XMP => 5-phospho-alpha-D-ribose 1-diphosphate + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32147", "l": "H2O + sepiapterin = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42343", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) <=> 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15011", "l": "7,8-dihydrofolate + H(+) + NADPH => (6S)-5,6,7,8-tetrahydrofolate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73298", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine <=> 7,8-dihydroxy-4'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635845", "l": "GLI proteins bind CDC73 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53746", "l": "glycine + H(+) + tRNA(Ala) => glycyl-tRNA(Ala) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68139", "l": "acetophenone + H(+) + NADPH <=> (R)-1-phenylethanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29920", "l": "alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP => ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102914", "l": "N-methyl-3-aminomethylindole N-methyltransferase activity", "d": ["Catalysis of the reaction: N-methyl-3-aminomethylindole + S-adenosyl-L-methionine = H+ + gramine + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626220", "l": "C2CD3 binds the mother centriole (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050252", "l": "retinol O-fatty-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964759", "l": "Alternative endo-mannosidase I route (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71812", "l": "3,3',5-triiodo-L-thyronine(out) => 3,3',5-triiodo-L-thyronine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1369052", "l": "ABCAs mediate lipid influx (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46911", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) <=> 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.1", "l": "\"D-aspartate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29738", "l": "butane-1-sulfonate + FMNH2 + O2 <=> butanal + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31039", "l": "dodecanoyl-CoA + FAD + H(+) = (2E)-dodecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57199", "l": "H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] <=> glycolate + H(+) + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74986", "l": "(3R)-3-isocyanylbutanoyl-AMP + holo-[ACP] <=> (3R)-3-isocyanylbutanoyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73797", "l": "FAICAR => IMP + H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201443", "l": "Type II receptor phosphorylates type I receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162363", "l": "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11303", "l": "1D-5-O-methyl-myo-inositol + NAD(+) <=> 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45850", "l": "3-oxododecanoyl-CoA + H(+) + NADPH => (3R)-3-hydroxydodecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43146", "l": "H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine => adenosine(22) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114544", "l": "p115-RhoGEF activation of RHOA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19222", "l": "2 formaldehyde + H2O => formate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018756", "l": "RHOH binds GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54124", "l": "coelenterazine h dioxetanone = CO2 + excited coelenteramide h monoanion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50605", "l": "acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878603", "l": "SSC5D binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41574", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH => lipoxin A4 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55963", "l": "4-(trimethylamino)butanoate + ATP + CoA <=> 4-(trimethylamino)butanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55961", "l": "4-(trimethylamino)butanoate + ATP + CoA => 4-(trimethylamino)butanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75155", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = diphosphate + verrucosan-2beta-ol", "d": []}, {"i": "EC:4.2.3.208", "l": "\"verrucosan-2beta-ol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76052", "l": "Binding of TFIIIA To type 1 Promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940959", "l": "Neurolysin degrades neurotensin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15098", "l": "5-formimidoyltetrahydrofolate + L-glutamate => (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003952", "l": "NAD+ synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16444", "l": "H2O + L-glutaminyl-[protein] <=> L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0016289", "l": "CoA hydrolase activity", "d": ["Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group."]}, {"i": "REACT:R-HSA-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37732", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5681980", "l": "ATG12 binds ATG7 dimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141409", "l": "Mad1 binds kinetochore (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51711", "l": "D-altritol + NAD(+) <=> H(+) + keto-D-tagatose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29779", "l": "ATP + H2O + L-methionine(out) = ADP + H(+) + L-methionine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60274", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706293", "l": "Active FLT3 binds to CBL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11455", "l": "7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033435", "l": "AUA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AUA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662669", "l": "Dopaquinone transforms to Leucodopachrome (Cyclodopa) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875523", "l": "MET binds TNS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102587", "l": "cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-O-(glucosyl)-p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoylglucose glucosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-[2''-O-(2'''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + 1-O-sinapoyl-beta-D-glucose <=> cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(2-O-sinapoyl-beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) + trans-sinapate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22817", "l": "alpha-D-xylose => alpha-D-xylulofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27416", "l": "2-oxoglutarate + codeine + O2 <=> CO2 + formaldehyde + morphine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13144", "l": "2-methylpropanoyl-CoA <=> butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043722", "l": "4-hydroxyphenylacetate decarboxylase activity", "d": ["Catalysis of the reaction: (4-hydroxyphenyl)acetate + H+ = 4-cresol + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445700", "l": "Myosin Binds ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34528", "l": "L-phenylalanine => (S)-3-amino-3-phenylpropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937807", "l": "SRC phosphorylates RUNX3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55806", "l": "(9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+) => (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59953", "l": "2,6-dimethylheptanoyl-CoA + H2O => 2,6-dimethylheptanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25193", "l": "(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-methylcatechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.233323709485049", "identifiers": [{"i": "GO:0019104", "l": "DNA N-glycosylase activity", "d": ["Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098621", "l": "O-phosphoseryl-tRNA(Sec) selenium transferase activity", "d": ["Catalysis of the reaction: O-phosphoseryl-tRNA(Sec) + selenophosphoric acid + H2O => L-selenocysteinyl-tRNA(Sec) + 2 phosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65284", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate = 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Thr-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67245", "l": "3-deoxyglucosone + H2O + NAD(+) => 2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201515", "l": "Active ALK recruits PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13541", "l": "H2O + tetrathionate = H(+) + sulfate + sulfur + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11420", "l": "NADPH + O2 + senecionine = H2O + NADP(+) + senecionine N-oxide", "d": []}, {"i": "EC:1.14.13.101", "l": "\"senecionine N-oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73466", "l": "carcinine + H2O <=> beta-alanine + histamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052926", "l": "dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917696", "l": "Cargo Sequestration (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71599", "l": "2-oxoglutarate(out) + maleate(in) = 2-oxoglutarate(in) + maleate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682377", "l": "LC3 de-lipidation by ATG4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46495", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24186", "l": "3,4-dihydroxybenzoate + CO2 => 4,5-dihydroxyphthalate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102516", "l": "delphinidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose <=> delphinidin 3,7-di O-beta-D-glucoside + ferulate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24608", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate + CO2 + H2O", "d": []}, {"i": "EC:4.2.1.41", "l": "\"5-dehydro-4-deoxyglucarate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222462", "l": "SodB reduces superoxide to H2O2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111956", "l": "Calmodulin activates Cam-PDE 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31198", "l": "(3S)-hydroxyoctanoyl-CoA + NAD(+) <=> 3-oxooctanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0004955", "l": "prostaglandin receptor activity", "d": ["Combining with a prostaglandin (PG) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090448", "l": "glucosinolate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucosinolate(out) + H+(out) = glucosinolate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64948", "l": "dCTP + H2O = dCDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70795", "l": "H(+)(in) + L-lysine(out) = H(+)(out) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0045289", "l": "luciferin monooxygenase activity", "d": ["Catalysis of the generalized reaction: luciferin + O2 = oxidized luciferin + CO2 + light. There may be additional substrates and reactants involved in the reaction. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30899", "l": "bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose = beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605768", "l": "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388560", "l": "EDNRA,EDNRB bind EDNs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35431", "l": "1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside = cyanidin 3,7-di-O-beta-D-glucoside + vanillate", "d": []}, {"i": "EC:2.4.1.300", "l": "\"cyanidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49279", "l": "CTP + phytyl phosphate <=> CDP + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40572", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62261", "l": "2 hydrogencarbonate(out) + Mn(2+)(out) => 2 hydrogencarbonate(in) + Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001540", "l": "amyloid-beta binding", "d": ["Binding to an amyloid-beta peptide/protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11446", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043819", "l": "precorrin-6A synthase (deacetylating) activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + H2O + precorrin-5 = S-adenosyl-L-homocysteine + acetate + 2 H+ + precorrin-6X."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32572", "l": "(E)-2-methylgeranyl diphosphate + H2O => 2-methylisoborneol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1980051", "l": "DLL4 binds NOTCH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.3.2", "l": "\"xanthine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45004", "l": "(R)-carnitine + 2,6-dimethylheptanoyl-CoA = CoA + O-2,6-dimethylheptanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40747", "l": "2-oxoglutarate + L-lysine + O2 = (3S)-3-hydroxy-L-lysine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.843050782660015", "identifiers": [{"i": "GO:0140457", "l": "protein demethylase activity", "d": ["Catalysis of the removal of a methyl group from a protein."]}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0042577", "l": "lipid phosphatase activity", "d": ["Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41662", "l": "NADH + sanguinarine => dihydrosanguinarine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52177", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674531", "l": "AAMP binds EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46398", "l": "an (11E)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.535054500181104", "identifiers": [{"i": "GO:0005509", "l": "calcium ion binding", "d": ["Binding to a calcium ion (Ca2+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34121", "l": "3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA => 3 H(+) + hexanoyl-CoA + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53547", "l": "chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11436", "l": "4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O", "d": []}, {"i": "EC:7.1.1.9", "l": "\"cytochrome-c oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944240", "l": "Association of procollagen type III (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22544", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74400", "l": "2 (S)-lactate(in) + prostaglandin F2alpha(out) => 2 (S)-lactate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20533", "l": "H2O + pyridoxal 5'-phosphate = phosphate + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341072", "l": "SUMOylation of RARA with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016630", "l": "protochlorophyllide reductase activity", "d": ["Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72467", "l": "2 acetyl-CoA + 5 H(+) + 6 malonyl-CoA = 6 CO2 + 8 CoA + H2O + o-orsellinate depside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65143", "l": "AH2 + O2 + protoaustinoid A <=> A + berkeleyone A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036025", "l": "Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)5 (PP-Dol)1 by ALG3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2995376", "l": "BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.73", "l": "\"feruloyl esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047714", "l": "galactolipase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-997237", "l": "SH2B proteins bind JAK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008043", "l": "MAPK8 phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874718", "l": "TTPA binds alpha-TOH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008118", "l": "N-acetyllactosaminide alpha-2,3-sialyltransferase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3965450", "l": "DAAM1 recruits PFN1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38748", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202960", "l": "Caspase mediated cleavage of C-IAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420975", "l": "Ca impermeable AMPA receptor ligand binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57574", "l": "7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21644", "l": "ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate", "d": []}, {"i": "EC:2.7.1.30", "l": "\"glycerol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030758", "l": "3,7-dimethylquercitin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109701", "l": "PDPK1 binds PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050470", "l": "trimethylamine dehydrogenase activity", "d": ["Catalysis of the reaction: trimethylamine + H2O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52208", "l": "alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53215", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57706", "l": "3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH => (2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66306", "l": "a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247840", "l": "WLS binds WNT ligands in the Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61989", "l": "cytidine(72) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37982", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine <=> 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57318", "l": "ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+) => ATP + cytidine 5'-diphosphoramidate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035487", "l": "thymine/thymine mispair binding", "d": ["Binding to a double-stranded DNA region containing a T/T mispair."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004960", "l": "thromboxane receptor activity", "d": ["Combining with a thromboxane (TXA) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731147", "l": "Syndecan-4 binds PI(4,5)P2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004814", "l": "arginine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22234", "l": "diphosphate + NADP(+) + squalene => H(+) + NADPH + presqualene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950782", "l": "p-STAT1 binds p-STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944220", "l": "Association of procollagen type XXIII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52369", "l": "3'-phosphoadenylyl sulfate + cholesterol => adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043273", "l": "CTPase activity", "d": ["Catalysis of the reaction: CTP + H2O = CDP + H+ + phosphate. May or may not be coupled to another reaction."]}, {"i": "RHEA:29387", "l": "CTP + H2O = CDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35571", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] = (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41537", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine => 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444100", "l": "PROT mediates L-proline uptake (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2512800", "l": "SCARB1:ligand is endocytosed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43393", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O => 1D-myo-inositol 1,3-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5624951", "l": "TNPO1 binds KIF17 dimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0008420", "l": "RNA polymerase II CTD heptapeptide repeat phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine/threonine (consensus YSPTSPS) + H2O = RNA polymerase II large subunit + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102862", "l": "1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity (SN2-18:3 forming)", "d": ["Catalysis of the reaction: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor = 1-18:2-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25907", "l": "futalosine + H2O <=> dehypoxanthine futalosine + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55225", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322434", "l": "XIAP dissociates from ub-TLE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392513", "l": "Rap1 signal termination by Rap1GAPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24749", "l": "L-methionine <=> 2-aminobut-2-enoate + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16301", "l": "H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694633", "l": "SARS virus buds into ERGIC lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5263628", "l": "CAV3:TRIM72:DYSF binds ANXAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689544", "l": "UCHL5 binds INO80 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801762", "l": "REG3A oligomerize to form a pore complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761843", "l": "NFE2L2-dependent GSR gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428752", "l": "Dissociation of the TP:Gq complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57553", "l": "[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] => (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16088", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658001", "l": "Defective LCT does not hydrolyze Lac (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27337", "l": "2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] = 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.8", "l": "\"steroid 15beta-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72022", "l": "2-oxoglutarate + H(+) + O2 + trihazone A <=> 2 CO2 + H2O + succinate + trihazone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34505", "l": "(+)-epi-alpha-bisabolol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30171", "l": "hexadecanoyl-[ACP] + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57213", "l": "dGTP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727349", "l": "XDH dehydrogenates xanthine to form urate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218804", "l": "p38 MAPK activation by VEGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944229", "l": "Association of procollagen type IX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72111", "l": "L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out) = L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61599", "l": "[DsbD protein]-dithiol + [thioredoxin]-disulfide <=> [DsbD protein]-disulfide + [thioredoxin]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75588", "l": "11-O-acetylcyathatriol + UDP-alpha-D-glucose => erinacine Q2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928646", "l": "EPHAs bind EFNAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75143", "l": "prosolanapyrone III = solanapyrone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47452", "l": "(2E,5Z)-tetradecadienoyl-CoA + H2O = (3S)-hydroxy-(5Z-tetradecenoyl)-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635843", "l": "GLI translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59954", "l": "2,6-dimethylheptanoate + CoA + H(+) => 2,6-dimethylheptanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40714", "l": "1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol <=> 1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70538", "l": "GDP-beta-L-fucose + L-seryl-[EGF-like domain protein] <=> 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21530", "l": "[phosphate](n-1) + H(+) + phosphate => [phosphate](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15896", "l": "Co-sirohydrochlorin + 2 H(+) <=> Co(2+) + sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847880", "l": "CYTH proteins bind ARF1:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71572", "l": "5-O-(L-seryl)-dTMP in DNA + H(+) => 5-aminoethoxy-methyl-dUMP in DNA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.96.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73504", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine => 3',4,7-trihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51000", "l": "[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine = [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.259", "l": "\"[fructose-bisphosphate aldolase]-lysine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15317", "l": "a 2-deoxy-alpha-D-glucoside + H2O = 2-deoxy-D-glucose + an alcohol", "d": []}, {"i": "EC:3.2.1.112", "l": "\"2-deoxyglucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610752", "l": "GLI3R translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23346", "l": "a purine nucleobase + D-ribose => a purine D-ribonucleoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604328", "l": "AKT1 phosphorylates NOTCH4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16667", "l": "(5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate => (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20616", "l": "3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine <=> adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67915", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195378", "l": "Homodimerization of VEGF proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18610", "l": "carbamoyl phosphate + N(2)-acetyl-L-ornithine => H(+) + N(2)-acetyl-L-citrulline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620891", "l": "FOXO3 binds BTG1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51826", "l": "AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + octanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801109", "l": "CHM binds RGGT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0032553", "l": "ribonucleotide binding", "d": ["Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14037", "l": "4,5beta-dihydrocortisone + NADP(+) = cortisone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50349", "l": "alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => a dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66970", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210439", "l": "glutamate uptake by astrocytes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893609", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [cytosolic] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15733", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2", "d": []}, {"i": "EC:1.17.99.3", "l": "\"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033902", "l": "rRNA endonuclease activity", "d": ["Catalysis of the hydrolysis of the phosphodiester linkage between guanosine and adenosine residues at one specific position in 28S rRNA from rat ribosomes."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046659", "l": "digestive hormone activity", "d": ["The action characteristic of a hormone that takes part in the digestion process."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75039", "l": "acetyl-CoA(in) = acetyl-CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65024", "l": "7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+) = dehydrocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167427", "l": "Opioid dissociates from MOR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21214", "l": "4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17091", "l": "D-glyceraldehyde 3-phosphate + pyruvate => 2-dehydro-3-deoxy-6-phospho-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0044389", "l": "ubiquitin-like protein ligase binding", "d": ["Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42331", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50283", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-984606", "l": "Kinesin-5 is a homotetramer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25632", "l": "myricetin + S-adenosyl-L-methionine <=> H(+) + laricitrin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74723", "l": "Endosome acidification (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39224", "l": "(3R)-hydroxyoctacosanoyl-CoA => (2E)-octacosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58149", "l": "ethyl acetate + H2O => acetate + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24270", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH => 2,6-dioxo-6-phenylhexanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018814", "l": "RHOT1 hydrolyzes GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20926", "l": "a [peptide]-C-terminal amide + glyoxylate => a [peptide]-C-terminal (2S)-2-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16163", "l": "2 Fe(II)-[leghemoglobin] + H(+) + NAD(+) => 2 Fe(III)-[leghemoglobin] + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004482", "l": "mRNA (guanine-N7-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41398", "l": "1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433454", "l": "Phosphorylation of GAB2 by SFKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380272", "l": "Plk1-mediated phosphorylation of Nlp (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624798", "l": "LBR binds KPNB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67911", "l": "a primary linear alkyl sulfate ester + H2O <=> a primary alcohol + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66975", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose <=> alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013145", "l": "RAC1 binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65179", "l": "A + protoaustinoid A <=> AH2 + protoaustinoid B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34104", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63466", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP => (2E,6E,10E)-geranylgeraniol + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46961", "l": "butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420980", "l": "Activation of Ca permeable AMPA receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9718360", "l": "GNRHR binds GNRHR peptide agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24936", "l": "H2O + imidazol-4-one => N-formimidoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71223", "l": "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035180", "l": "Expression of EEPD1 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67979", "l": "all-trans-neurosporene <=> beta-zeacarotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45061", "l": "H2O + N-(9Z-octadecenoyl) ethanolamine => (9Z)-octadecenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381644", "l": "ER calcium channels open in response to activated PKA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45160", "l": "3-oxopropanoate + H(+) = acetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34780", "l": "a 3alpha-hydroxysteroid + NAD(+) => a 3-oxosteroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74733", "l": "Insulin receptor de-phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60786", "l": "CO2 + gibberellin A25 + H(+) + succinate => 2-oxoglutarate + gibberellin A24 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944216", "l": "Association of procollagen type XV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950387", "l": "CANX binds EBI3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.6", "l": "\"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034736", "l": "cholesterol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983307", "l": "IL15 binds IL15RA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.-", "l": "\"Carboxy-lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963589", "l": "ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57276", "l": "a 2'-deoxyguanosine in DNA + glyoxal = an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000074", "l": "TCN2 binds RCbl in the circulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25565", "l": "H2O + N-acetyl-4-O-acetylneuraminate => acetate + H(+) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18388", "l": "acetone + 2 ATP + 3 H2O + hydrogencarbonate <=> acetoacetate + 2 AMP + 4 H(+) + 4 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57725", "l": "H(+) + 2 Na(+)(in) + oxaloacetate => CO2 + 2 Na(+)(out) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51481", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47899", "l": "6-sulfo-D-quinovose + NAD(+) <=> 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63567", "l": "apelin-13 + H2O <=> apelin-12 + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33891", "l": "chanoclavine-I + NAD(+) = chanoclavine-I aldehyde + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.332", "l": "\"chanoclavine-I dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710106", "l": "ELANE cleaves GSDMD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30435", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly)", "d": []}, {"i": "EC:2.3.2.16", "l": "\"lipid II:glycine glycyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000319", "l": "BORA binds PLK1 and AURKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51986", "l": "all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68830", "l": "camphor + H(+) + NADH => borneol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48907", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17090", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate => D-glyceraldehyde 3-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61663", "l": "(2E)-geraniol + ATP <=> (2E)-geranyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49841", "l": "(-)-dehydrodiconiferyl acid + 2 a quinone + H2O => (-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353500", "l": "Nuclear focus formation by interaction of chSNM1A with PIAS1 upon DNA lesion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28405", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) <=> ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981622", "l": "Myoglobin:oxygen dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60217", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71865", "l": "taurodeoxycholate(in) => taurodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13268", "l": "1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine <=> 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62972", "l": "acetyl-CoA + 2 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + orsellinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69407", "l": "uracil(in) <=> uracil(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12512", "l": "D-aspartate + H2O + O2 = H2O2 + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2197690", "l": "Detachment of WASP/WAVE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024624", "l": "Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32654", "l": "erythromycin D + S-adenosyl-L-methionine <=> erythromycin B + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102997", "l": "progesterone 5beta- reductase activity", "d": ["Catalysis of the reaction: H+ + progesterone + NADPH <=> 5beta-pregnane-3,20-dione + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0009679", "l": "hexose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) + H+(out) = hexose(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19613", "l": "dimethyl sulfide + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + trimethylsulfonium", "d": []}, {"i": "EC:2.1.1.96", "l": "\"thioether S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41448", "l": "2-oxoglutarate + L-isoleucine + O2 = (4S)-4-hydroxy-L-isoleucine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.45", "l": "\"L-isoleucine 4-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578712", "l": "Importin-8 binds AGO2:miRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761474", "l": "AMOT-2 binds CDH11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75534", "l": "AH2 + N-acetyl-S-hydroxy-L-cysteine <=> A + H2O + N-acetyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59506", "l": "[protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein] => cholesterol + glycyl-L-cysteinyl-[protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624668", "l": "CEBPA binds CDKN1A (p21) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64410", "l": "2 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in) => 2 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636560", "l": "Eis acetylates DUSP16 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75886", "l": "NAD(+) <=> ADP-1-deoxy-1,O(4)-didehydro-D-ribose + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404144", "l": "Parenchymal atROL translocates to HSCs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75916", "l": "H2O + NAD(+) + serinol => dihydroxyacetone + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097371", "l": "MDM2/MDM4 family protein binding", "d": ["Binding to a member of the MDM2/MDM4 protein family, comprising negative regulators of p53."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74996", "l": "epierythrostominol(in) => epierythrostominol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19205", "l": "dCTP + 2 H2O = diphosphate + dUMP + NH4(+)", "d": []}, {"i": "EC:3.5.4.30", "l": "\"dCTP deaminase (dUMP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49067", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol <=> calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37471", "l": "3-methylbutanoyl-CoA + S-adenosyl-L-methionine = CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.3.1.228", "l": "\"isovaleryl-homoserine lactone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134904", "l": "Phosphorylation of beta-catenin at Ser552 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9704248", "l": "CHRM4 binds CHRM4 antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16926", "l": "(E)-caffeoyl-CoA + S-adenosyl-L-methionine => (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685953", "l": "SIRT6 deacetylates RBBP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209081", "l": "Disassembly of the destabilised 'destruction complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68477", "l": "a (2R)-2-hydroperoxy fatty acid + H(+) => a fatty aldehyde + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004414", "l": "homoserine O-acetyltransferase activity", "d": ["Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689000", "l": "AADAC deacetylates PHEN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26511", "l": "H2O + L-prolinamide => L-proline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71033", "l": "L-cysteine(out) + L-phenylalanine(in) => L-cysteine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71982", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + fusoxypene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604752", "l": "Initial activation of proMMP13 by MMP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44607", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.12", "l": "\"Xaa-Xaa-Pro tripeptidyl-peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.26", "l": "\"pseudolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66646", "l": "diphosphate + trichobrasilenol => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684218", "l": "M protein oligomerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46659", "l": "androst-4-ene-3,17-dione + H(+) + NADPH <=> 5beta-androstane-3,17-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209828", "l": "Tryptophan is hydroxylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25713", "l": "2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase] => L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953111", "l": "E2F6 binds TFDP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44762", "l": "6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799246", "l": "CHEK1 phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66386", "l": "scalar-17(25)-en-19-ol => (2E,6E,10E,14E)-geranylfarnesol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139918", "l": "Phosphorylation of BIM by JNK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38375", "l": "bacterioruberin = bisanhydrobacterioruberin + 2 H2O", "d": []}, {"i": "EC:4.2.1.161", "l": "\"bisanhydrobacterioruberin hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75301", "l": "2'cADPR + H(+) + nicotinamide => NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17231", "l": "an acetyl ester + CoA => acetyl-CoA + an aliphatic alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14409", "l": "cysteamine + O2 = H(+) + hypotaurine", "d": []}, {"i": "EC:1.13.11.19", "l": "\"cysteamine dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73776", "l": "dimethylallyl diphosphate + preechinulin => diphosphate + tardioxopiperazine B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36846", "l": "(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48082", "l": "ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47785", "l": "cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791060", "l": "Expression of SRPRB (SRP Receptor subunit beta) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788999", "l": "HV1-mediated H+ transfer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106366", "l": "guanosine kinase activity", "d": ["Catalysis of the reaction: ATP + guanosine = ADP + GMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186765", "l": "PLC-gamma binds to the active receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102629", "l": "patuletin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: patuletin + S-adenosyl-L-methionine <=> quercetagetin 3',6-dimethyl ether + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112430", "l": "Formation of P-TEFb complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22929", "l": "4-acetamidobutanoyl-CoA + H2O => 4-aminobutanoyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21144", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.5.98.2", "l": "\"5,10-methylenetetrahydromethanopterin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030564", "l": "tRNA 2'-O-ribose methylation guide activity", "d": ["Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050302", "l": "indole-3-acetaldehyde oxidase activity", "d": ["Catalysis of the reaction: (indol-3-yl)acetaldehyde + H2O + O2 = (indol-3-yl)acetate + H2O2 + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67080", "l": "a very long-chain fatty acid(in) + ATP + H2O = a very long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983156", "l": "Polyubiquitination of substrate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9704248", "l": "CHRM4 binds CHRM4 antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20711", "l": "ATP + erythritol <=> ADP + D-erythritol 4-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607740", "l": "PKC-delta phosphorylates CARD9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52084", "l": "13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71168", "l": "glycine(out) + H(+)(in) + Na(+)(out) => glycine(in) + H(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36722", "l": "hexacosenoyl-CoA + sphinganine <=> CoA + H(+) + N-hexacosenoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26528", "l": "a (2E)-enoyl-CoA + H2O => a (3R)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68753", "l": "alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] => alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-481010", "l": "Surface deployment of platelet dense granule membrane components (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754978", "l": "Unknown kinase phosphorylates RBV-MP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018766", "l": "RHOU binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74659", "l": "N-acetyl-D-glucosamine + UTP = H(+) + N-acetyl-D-glucosamine 6-phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60858", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28146", "l": "geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] = 3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.174", "l": "\"geranylhydroquinone 3''-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32838", "l": "4-(trimethylamino)butanoate(in) <=> 4-(trimethylamino)butanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28242", "l": "O2 + pratensein + reduced [NADPH--hemoprotein reductase] = 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39498", "l": "3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5227009", "l": "ABCF1 binds EIF2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20236", "l": "a 7beta-hydroxysteroid + NADP(+) <=> a 7-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61829", "l": "stigmasterol + UDP-alpha-D-glucose => H(+) + stigmasteryl 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31589", "l": "(Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+) => FMNH2 + NADH + O2 + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14803", "l": "(2R)-3-phospho-glyceroyl phosphate + ADP => (2R)-3-phosphoglycerate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11077", "l": "anthranilate + 3 H(+) + NADH + O2 => catechol + CO2 + NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20336", "l": "ATP + L-seryl-[acetyl-CoA carboxylase] <=> ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22038", "l": "[phosphate](n-1) + D-glucose 6-phosphate + H(+) => [phosphate](n) + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45014", "l": "(4R)-hydroxysphinganine + octadecanoate => H2O + N-octadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951727", "l": "cAMP binds PKA tetramer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791134", "l": "Expression of SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8986258", "l": "SLIT2:ROBO1 binds CXCR4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58368", "l": "(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) = (2E,6Z)-nona-2,6-dienal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10852", "l": "dimethylallyl diphosphate + leachianone G = diphosphate + sophoraflavanone G", "d": []}, {"i": "EC:2.5.1.71", "l": "\"leachianone-G 2''-dimethylallyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031404", "l": "chloride ion binding", "d": ["Binding to a chloride ion (Cl-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66136", "l": "acetyl-CoA + tyramine = CoA + H(+) + N-acetyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9828175", "l": "Formation of the NSL complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19942", "l": "norcoclaurine + S-adenosyl-L-methionine => coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42944", "l": "cytidine(40) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854052", "l": "Formation of the SCF-FBXL7 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156699", "l": "Inactivation of Wee1 kinase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31754", "l": "chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74638", "l": "2-oxoglutarate + 5-dehydro-6-demethoxyfumagillol + O2 <=> 5-dehydro-6-demethoxy-6-hydroxyfumagillol + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65409", "l": "NAD(+)(in) => NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69909", "l": "2 Na(+)(in) + uridine(in) => 2 Na(+)(out) + uridine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41656", "l": "dihydrosanguinarine + NADP(+) = NADPH + sanguinarine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35110", "l": "3-nitrotyramine + H2O + O2 <=> 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44440", "l": "a 1,3-diacylglycerol + a 1-acylglycerol = a triacylglycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34497", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62150", "l": "dGDP + dTDP => dGTP + dTMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:1904091", "l": "non-ribosomal peptide synthetase activity", "d": ["Catalysis of a multistep reaction that produce non-ribosomal peptides. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72351", "l": "glutarate(in) + glycocholate(out) = glutarate(out) + glycocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44723", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16533", "l": "L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP", "d": []}, {"i": "EC:2.4.1.94", "l": "\"protein N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59905", "l": "H2O + NADP(+) + octanal => 2 H(+) + NADPH + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62936", "l": "H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432067", "l": "Aquaporin-4 passively transports water out of cell (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944215", "l": "Association of procollagen type XX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421831", "l": "trans-Golgi Network Coat Assembly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75281", "l": "an omega-hydroxy-medium-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56917", "l": "3beta-hydroxy-5alpha-androstan-17-one + NADP(+) => 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21361", "l": "ATP + beta-nicotinamide D-ribonucleotide + H(+) => diphosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70690", "l": "4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) <=> 4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13723", "l": "H(+) + testolate => H2O + testololactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41412", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50652", "l": "2-(3-methylsulfanyl)propylmalate = 2-(2-methylsulfanyl)propylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2870221", "l": "E-selectin binds E-selectin ligand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41568", "l": "aclacinomycin T + dTDP-2-deoxy-beta-L-fucose = aclacinomycin S + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6790454", "l": "SUMOylation of XPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61993", "l": "N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28443", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + dodecanoyl-[ACP] => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58786", "l": "a 5'-end triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9737780", "l": "MTTP binds lomitapide (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12517", "l": "(2E,6E)-farnesyl diphosphate => (+)-(R)-germacrene A + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47072", "l": "1-eicosanoylglycerol + H2O = eicosanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22344", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA = (R)-rosmarinate + CoA", "d": []}, {"i": "EC:2.3.1.140", "l": "\"rosmarinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005523", "l": "tropomyosin binding", "d": ["Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61223", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672951", "l": "Inactive RAFs bind YWHAB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32024", "l": "(2E,6E)-farnesyl diphosphate + H2O => avermitilol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36776", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35464", "l": "lathosterol + NAD(+) => 5alpha-cholest-7-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854466", "l": "VLDLR binds RELN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41921", "l": "3-oxooctadecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69215", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ATP + L-glutamate <=> (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51799", "l": "deoxycohumulone + dimethylallyl diphosphate <=> colupulone + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429101", "l": "HMIT co-transports myo-inositol with a proton (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37033", "l": "2-dehydro-3-deoxy-D-arabinonate + H2O => D-ribonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168038", "l": "Collagen type XV restin release (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19762", "l": "FMN-N(5)-oxide + H(+) + NADH => FMN + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16524", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60166", "l": "an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine => a guanosine in RNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050295", "l": "steryl-beta-glucosidase activity", "d": ["Catalysis of the reaction: cholesteryl-beta-D-glucoside + H2O = D-glucose + cholesterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169394", "l": "ISGylation of IRF3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53172", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021847", "l": "CREB1 gene expression is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12183", "l": "anthranilate + S-adenosyl-L-methionine <=> H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70591", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32066", "l": "8-oxo-dGDP + H2O <=> 8-oxo-dGMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58845", "l": "(6E)-8-hydroxygeranial + NAD(+) => (6E)-8-oxogeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19784", "l": "2-oxoglutarate + 3,5-diiodo-L-tyrosine <=> 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14204", "l": "D-lyxose <=> D-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844447", "l": "NLRP1 senses MDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37581", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0009033", "l": "trimethylamine-N-oxide reductase activity", "d": ["Catalysis of the reaction: NADH + H+ + trimethylamine-N-oxide = NAD+ + trimethylamine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63737", "l": "2-phenylacetaldehyde + H(+) + NADPH => 2-phenylethanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418856", "l": "Activation of Rac1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10168", "l": "15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] = biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.7.2", "l": "\"15,16-dihydrobiliverdin:ferredoxin oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38792", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57245", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP => dGTP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781922", "l": "USP13 binds UFD1L:SKP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12319", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24706", "l": "(6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose = (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose", "d": []}, {"i": "EC:2.1.2.13", "l": "\"UDP-4-amino-4-deoxy-L-arabinose formyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19027", "l": "H2O2 + NH4(+) + oxaloacetate => H2O + L-aspartate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27925", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 <=> 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785762", "l": "IL13RA1 binds TYK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140506", "l": "endoplasmic reticulum-autophagosome adaptor activity", "d": ["The binding activity of a molecule that brings together an ER membrane and an autophagosome during reticulophagy."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65783", "l": "2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046966", "l": "nuclear thyroid hormone receptor binding", "d": ["Binding to a nuclear thyroid hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12836", "l": "an N-acyl-D-glutamate + H2O <=> a carboxylate + D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000225", "l": "N-acetylglucosaminylphosphatidylinositol deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948582", "l": "miR-17 microRNA binds VAPA mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54118", "l": "diphosphate + pseudolaratriene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51134", "l": "2-deoxy-D-ribose 5-phosphate + a purine nucleobase => a purine 2'-deoxyribonucleoside 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380930", "l": "Phosphorylated AMPK binds AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33076", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine => 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32729", "l": "a very-long-chain 3-oxoacyl-CoA + CO2 + CoA => a very-long-chain acyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56410", "l": "1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44212", "l": "3-hydroxytetradecanoate + ATP + CoA = 3-hydroxytetradecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799097", "l": "ATM phosphorylates ZNF420 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11131", "l": "4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74801", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868236", "l": "BAR domain proteins recruit dynamin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20947", "l": "S-adenosyl-L-methionine + theobromine <=> caffeine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849906", "l": "SALM1 binds NMDA receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74391", "l": "methylamine(out) = methylamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2870221", "l": "E-selectin binds E-selectin ligand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30081", "l": "AMP + crotonobetainyl-CoA + diphosphate => ATP + CoA + crotonobetaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114264", "l": "Translocation of activated BAX to the mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.054311793581761", "identifiers": [{"i": "GO:0017171", "l": "serine hydrolase activity", "d": ["Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25718", "l": "N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13740", "l": "an n-alkanal + NADP(+) <=> an alk-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27338", "l": "2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] => 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75815", "l": "ATP + H2O + K(+)(in) = ADP + H(+) + K(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8979071", "l": "KDM6B binds iron (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29164", "l": "2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out) => 2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001069", "l": "glycogen binding", "d": ["Binding to glycogen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66476", "l": "gypsogenate + UDP-alpha-D-glucose = gypsogenate 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38448", "l": "4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O => 4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68528", "l": "(2E,6E)-farnesyl diphosphate = beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57736", "l": "A + all-trans-3,4-didehydro-13,14-dihydroretinol = AH2 + all-trans-3,4-didehydroretinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033472", "l": "FGFR2c mutants bind an expanded range of ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106282", "l": "isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: 3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD+ = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H+ + NADH."]}, {"i": "RHEA:42024", "l": "3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48464", "l": "ganglioside GM1b + H2O = ganglioside GA1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1461971", "l": "Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65211", "l": "(3S)-3-hydroxybutanoyl-CoA + H2O <=> (S)-3-hydroxybutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114558", "l": "Thrombin-activated PARs activate Gq (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54239", "l": "1,2-didecanoyl-sn-glycerol + CDP-choline <=> 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708275", "l": "PDE4A binds PDE4A inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103043", "l": "5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase activity", "d": ["Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O <=> H+ + alpha-D-ribose 1,5-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16467", "l": "2 Fe(II)-[cytochrome c553] + 2 H(+) + pyruvate => (R)-lactate + 2 Fe(III)-[cytochrome c553]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209910", "l": "Iodide is taken up by thyroid epithelial cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65751", "l": "2-oxoglutarate + dodecyl sulfate + O2 <=> CO2 + dodecanal + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63903", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) <=> (2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654514", "l": "KAL1 binds FGFR1c (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120297", "l": "histone dopaminyltransferase activity", "d": ["Catalysis of the reaction: dopamine + L-glutaminyl-[histone] = 5-dopaminyl-L-glutamyl-[histone] + NH4(+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42336", "l": "[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.8.7.2", "l": "\"ferredoxin:thioredoxin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13137", "l": "cycloartenol + S-adenosyl-L-methionine = cyclolaudenol + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.142", "l": "\"cycloartenol 24-C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59485", "l": "arsenite + 2 Fe(III)-[cytochrome c] + H2O => arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10603", "l": "prostaglandin H2 <=> prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38758", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45668", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67087", "l": "ATP + H2O + hexacosanoate(in) <=> ADP + H(+) + hexacosanoate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50625", "l": "acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O => a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68352", "l": "pppA(2'-5')pG = 3',2'-cGAMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60514", "l": "an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine => a guanosine in miRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265177", "l": "Exocyst complex formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640321", "l": "2,3-DKG hydrolyses to ERU and oxalate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62254", "l": "2 hydrogencarbonate(in) + Zn(2+)(in) => 2 hydrogencarbonate(out) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39360", "l": "(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40158", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372819", "l": "PCK2 phosphorylates OA to yield PEP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36830", "l": "dioscin + 3 H2O <=> D-glucose + diosgenin + 2 L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031926", "l": "pyridoxal phosphate transmembrane transporter activity", "d": ["Enables the transfer of pyridoxal phosphate from one side of a membrane to the other. Pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019782", "l": "ISG15 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693111", "l": "RHOF auto-activates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018676", "l": "(S)-limonene 7-monooxygenase activity", "d": ["Catalysis of the reaction: (4S)-limonene + H+ + NADPH + O2 = (4S)-perillyl alcohol + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111956", "l": "Calmodulin activates Cam-PDE 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202127", "l": "eNOS synthesizes NO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032001", "l": "1,4-alpha-glucan 6-alpha-glucosyltransferase activity", "d": ["Catalysis of the transfer an alpha-D-glucosyl residue in a (1->4)-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a (1->4)-alpha-D-glucan."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047622", "l": "adenosine nucleosidase activity", "d": ["Catalysis of the reaction: adenosine + H2O = D-ribose + adenine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047153", "l": "deoxycytidylate 5-hydroxymethyltransferase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyldeoxycytidylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653974", "l": "Ragulator binds Rag dimers (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201685", "l": "Beta-catenin is released from the destruction complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33597", "l": "CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40575", "l": "glutaryl-CoA + H2O = CoA + glutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2130706", "l": "MHC class II antigen processing (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14298", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O => an N-acylsphing-4-enine + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625883", "l": "PKN1 in complex with AR positively regulates expression of KLK2 and KLK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15859", "l": "17alpha-hydroxyprogesterone + H(+) + NADPH => (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237129", "l": "Acireductone is created (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55145", "l": "[(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+) => [4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047198", "l": "cysteine-S-conjugate N-acetyltransferase activity", "d": ["Catalysis of the reaction: S-substituted L-cysteine + acetyl-CoA = S-substituted N-acetyl-L-cysteine + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55396", "l": "(R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620717", "l": "p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43073", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41156", "l": "1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-(8E)-octadecenoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2545253", "l": "Deacetylation of cohesin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49490", "l": "2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+) => GDP-4-dehydro-alpha-D-rhamnose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-435244", "l": "PECAM1 is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47469", "l": "(2E,4E)-tetradecadienoyl-CoA => (3E,5Z)-tetradecadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67365", "l": "H2O + L-threonyl-L-serine => L-serine + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.43", "l": "\"beta-L-rhamnosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010294", "l": "abscisic acid glucosyltransferase activity", "d": ["Catalysis of the reaction: (+)-abscisate + UDP-D-glucose = abscisic acid glucose ester + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66501", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444527", "l": "FPR is a receptor for formyl peptides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798044", "l": "BTG2 binds CCR4-NOT complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373134", "l": "succinate + CoASH + ATP <=> succinylCoA + ADP + Pi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036122", "l": "BMP binding", "d": ["Binding to a member of the bone morphogenetic protein (BMP) family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51710", "l": "H(+) + keto-D-tagatose + NADH => D-altritol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14019", "l": "ADP + beta-nicotinamide D-ribonucleotide + H(+) => ATP + beta-nicotinamide D-riboside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140808", "l": "NAD+-protein-tyrosine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-tyrosyl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]."]}, {"i": "RHEA:58236", "l": "L-tyrosyl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21557", "l": "[calmodulin]-L-lysine + S-adenosyl-L-methionine => [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45988", "l": "3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2 = 3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18168", "l": "biphenyl + H(+) + NADH + O2 <=> (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73994", "l": "geranylgeranyl diphosphate <=> beta-araneosene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20046", "l": "3-oxopropanoate + H2O + NAD(+) => 2 H(+) + malonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72621", "l": "methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + salicylate => 2-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15194", "l": "dGTP + H2O => 2'-deoxyguanosine + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65855", "l": "a 3-oxo-Delta(1)-steroid + H2O <=> a 1-hydroxy-3-oxo steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168376", "l": "STIM1 oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70336", "l": "2-carboxy-L-lyxonolactone + H2O => 2-carboxy-L-lyxonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61152", "l": "(E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018545", "l": "NAD(P)H nitroreductase activity", "d": ["Catalysis of the conversion of a nitrate group to an amino or hydroxylamino group on toluene or a toluene derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54725", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735335", "l": "Expression of HAND2 in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52442", "l": "a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57944", "l": "H(+) + H2O2 + harderoheme III = CO2 + 2 H2O + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75318", "l": "chloride(out) + D-serine(out) + 2 Na(+)(out) <=> chloride(in) + D-serine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59677", "l": "D-maltotetraose + O2 => D-maltotetraono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13479", "l": "H(+) + indole-3-pyruvate + NADPH + NH4(+) => H2O + L-tryptophan + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34071", "l": "trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP", "d": []}, {"i": "EC:2.7.8.35", "l": "\"UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426223", "l": "Cation influx mediated by TRPC3/6/7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029453", "l": "Phosphorylation of VAV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58247", "l": "H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] <=> ADP-D-ribose + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50313", "l": "2-oxopentanoate + H(+) => butanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71722", "l": "H(+)(out) + L-methionyl-L-phenylalanyl-L-methionine(out) <=> H(+)(in) + L-methionyl-L-phenylalanyl-L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11169", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) => 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72051", "l": "butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57739", "l": "A + all-trans-3,4-didehydro-13,14-dihydroretinol <=> AH2 + all-trans-3,4-didehydroretinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61453", "l": "H(+) + NADPH + O2 + oxytetracycline => 11a-hydroxy-oxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578777", "l": "DMPK phosphorylates PLN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48953", "l": "14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) => 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28695", "l": "hydrogencarbonate(in) = hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37529", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781953", "l": "YOD1 binds VCP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30282", "l": "2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73263", "l": "genkwanin + S-adenosyl-L-methionine = apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34437", "l": "4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine => 4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73516", "l": "UDP(out) + UTP(in) => UDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647980", "l": "mature RAS proteins translocate to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734274", "l": "Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008833", "l": "deoxyribonuclease IV (phage-T4-induced) activity", "d": ["Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43931", "l": "pregn-5-ene-3,20-dione <=> progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22688", "l": "D-alanine + H2O + O2 = H2O2 + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63495", "l": "H(+) + menadione + NADPH <=> menadiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75172", "l": "Formation of RAD50:MRE11 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12601", "l": "2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate", "d": []}, {"i": "EC:2.6.1.39", "l": "\"2-aminoadipate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29933", "l": "ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48097", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14340", "l": "3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51361", "l": "H2O + N-(9Z-octadecenoyl)-L-leucine => (9Z)-octadecenoate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371582", "l": "HSBP1 binds HSF1 trimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-179410", "l": "Association of Nek2A with MCC:APC/C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139941", "l": "Binding of IP3 to IP3 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64853", "l": "benzoyl-CoA + octan-1-ol => CoA + octyl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60379", "l": "D-glucose(out) <=> D-glucose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.2", "l": "\"DNA topoisomerase (ATP-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40630", "l": "H2O + trihexadecanoylglycerol <=> 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50526", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696816", "l": "tRNA ligase complex ligates tRNA exons (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73669", "l": "(E,E)-piperlonguminine + CoA + H(+) => (E,E)-piperoyl-CoA + 2-methylpropan-1-amine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617828", "l": "TRIP11:IFT20 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70954", "l": "D-serine + H2O + O2 <=> 3-hydroxypyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20743", "l": "H2O + trans-2,3-epoxysuccinate <=> (2R,3S)-tartrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33031", "l": "H(+) + keto-D-fructose + NADH = D-sorbitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41167", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042017", "l": "interleukin-22 binding", "d": ["Binding to interleukin-22."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446372", "l": "Association of  PARVA with TESK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56707", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13019", "l": "5-phospho-alpha-D-ribose 1-diphosphate + uracil => diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74407", "l": "2 (S)-lactate(in) + thromboxane B2(out) = 2 (S)-lactate(out) + thromboxane B2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802938", "l": "Inhibitors bind and inhibit highly active BRAF mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24434", "l": "acetate + H(+) + oxalate => H2O + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38843", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10260", "l": "ATP + H2O + Mg(2+)(out) = ADP + H(+) + Mg(2+)(in) + phosphate", "d": []}, {"i": "EC:7.2.2.14", "l": "\"P-type Mg(2+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54121", "l": "coelenterazine h + O2 => coelenterazine h dioxetanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19048", "l": "acetyl-CoA + H2O + pyruvate <=> (3R)-citramalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35075", "l": "doxorubicin(in) + H(+)(out) = doxorubicin(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036243", "l": "succinate-semialdehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030409", "l": "glutamate formimidoyltransferase activity", "d": ["Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5323526", "l": "FRAT proteins bind GSK3beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392513", "l": "Rap1 signal termination by Rap1GAPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47842", "l": "(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate => [5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67178", "l": "H(+) + methanol + O13(4)-desmethyl pFDCC => H2O + primary fluorescent dioxobilin-type chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615570", "l": "miR-137 binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44731", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20365", "l": "phosphoethanolamine + S-adenosyl-L-methionine = H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102254", "l": "neoagarotetraose 1,3-alpha-3,6-anhydro-L-galactosidase activity", "d": ["Catalysis of the reaction: neoagarotetraose + H2O <=> 3,6-anhydro-alpha-L-galactopyranose + agarotriose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3244614", "l": "cGAS produces cyclic GMP-AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19472", "l": "NADH + 2 nitric oxide + 2 O2 <=> H(+) + NAD(+) + 2 nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172433", "l": "Collagen type XIX degradation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61158", "l": "CoA + GDP + H(+) => 3'-dephospho-CoA + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371591", "l": "Trimerization of cytosolic HSF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62360", "l": "FMN-N(5)-peroxide + uracil = (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63046", "l": "H(+) + mevinic carboxylate => H2O + mevastatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66999", "l": "2-methylpentanoate + ATP + CoA <=> 2-methylpentanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28513", "l": "arbutin 6-phosphate + H2O <=> beta-D-glucose 6-phosphate + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166387", "l": "The FA anion diffuses away laterally from UCP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66113", "l": "2-oxobutanoate + L-tyrosine => (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68896", "l": "4-hydroxybenzoate + ATP + H(+) + NADPH = 4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358512", "l": "MLH1:PMS2 makes single strand incision near  insertion/deletion loop of 2 bases or more (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008704", "l": "5-carboxymethyl-2-hydroxymuconate delta-isomerase activity", "d": ["Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-593685", "l": "Netrin-4 binds DCC/UNC5A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112514", "l": "JAK activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17158", "l": "ATP + creatine => ADP + H(+) + N-phosphocreatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70079", "l": "2-oxoglutarate + clavatol + O2 = CO2 + hydroxyclavatol + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22390", "l": "CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine => acetyl-CoA + N(6)-hydroxy-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36545", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate => H2O + mycothiol S-conjugate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47619", "l": "ethionamide + H(+) + NADPH + O2 <=> ethionamide S-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11599", "l": "H(+) + orotidine 5'-phosphate <=> CO2 + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694338", "l": "nsp1-4 cleaves itself (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43007", "l": "H(+) + O-carbamoyl-L-serine <=> 2-aminoprop-2-enoate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375302", "l": "Kinetochore capture of astral microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.36", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45718", "l": "CoA + glycine betaine + H(+) => H2O + N,N,N-trimethylglycyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61900", "l": "AH2 + betaenone C = A + betaenone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018848", "l": "pinocarveol isomerase activity", "d": ["Catalysis of the reaction: pinocarveol = carveol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701064", "l": "TRPV1 binds TRPV1 agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60446", "l": "an S-substituted L-cysteine + glycine => an S-substituted L-cysteinylglycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29700", "l": "dimethyl sulfoxide(in) => dimethyl sulfoxide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29393", "l": "diphosphate + GMP + H(+) => GTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30569", "l": "5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate => 5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682983", "l": "ATM phosphorylates WHSC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42635", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47246", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+) => (2R)-3-phosphoglycerate + an NDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40586", "l": "H2O + hexanedioyl-CoA <=> CoA + H(+) + hexanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55765", "l": "1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O => 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687097", "l": "p-S857 NCOA3 binds ETV4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008712", "l": "ADP-glyceromanno-heptose 6-epimerase activity", "d": ["Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0050694", "l": "galactose 3-O-sulfotransferase activity", "d": ["Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047657", "l": "alpha-1,3-glucan synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + [alpha-D-glucosyl-(1,3)]n = UDP + [alpha-D-glucosyl-(1,3)]n+1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174916", "l": "Formation of N-glucuronides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805785", "l": "AKT phosphorylates PHF20 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70849", "l": "L-arginine(out) + L-cysteine(in) + Na(+)(in) => L-arginine(in) + L-cysteine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961846", "l": "CCNE1 gene transcription is stimulated by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51128", "l": "A + an aliphatic amine + H2O = AH2 + an aldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27800", "l": "all-trans-octaprenyl diphosphate + 5 diphosphate => (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9640167", "l": "RRAGA,B exchanges GDP for GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033238", "l": "PEX5L:PEX7:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49591", "l": "L-erythrulose 1-phosphate <=> D-erythrulose 4-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336443", "l": "LIN7, CASK and APBA1 bind (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0016435", "l": "rRNA (guanine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114558", "l": "Thrombin-activated PARs activate Gq (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667456", "l": "AVPR1A,B bind desmopressin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38074", "l": "2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37817", "l": "2-methyl-4-chlorophenol + CO2 + pyruvate + succinate => (R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42313", "l": "H(+) + NADP(+) + 2 reduced [adrenodoxin] => NADPH + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205231", "l": "Dimerization of KIT upon SCF binding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18451", "l": "AH2 + arsenate + H(+) => A + arsenite + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.119", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015650", "l": "lactate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactate (out) + H+ (out) = lactate (in) + H+ (in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34641", "l": "H2O + NADP(+) + neopentalenolactone D => 1-deoxy-11-oxopentalenate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432521", "l": "Nuclear TIM is degraded by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30611", "l": "A + all-trans-zeta-carotene = AH2 + all-trans-neurosporene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68892", "l": "3-methoxybenzoate + ATP + H(+) + NADPH = 3-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648268", "l": "HTR1A binds HTR1A antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21038", "l": "acetoacetyl-CoA + CoA => 2 acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55932", "l": "3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O = AMP + H(+) + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34020", "l": "a 1-acylglycerol + H2O => a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40847", "l": "eicosanoyl-CoA + FAD + H(+) = (2E)-eicosenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800797", "l": "The PIDDosome activates CASP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48835", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69058", "l": "H2O + N(delta)-hydroxy-N(omega)-methyl-L-arginine + NAD(+) => H(+) + N(omega)-methyl-L-arginine + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52533", "l": "adenosine + GTP => AMP + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67292", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5444516", "l": "Formation of MSH2:MSH6 Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737046", "l": "L-Glutamate binds GRM4 (mGluR4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357479", "l": "p-AXL binds PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13607", "l": "2 H2O + 2 L-dehydroascorbate => 2 L-ascorbate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23459", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> A + crepenynate + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391168", "l": "SIRP gamma binds CD47 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51126", "l": "pseudouridine in snRNA => uridine in snRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004961", "l": "thromboxane A2 receptor activity", "d": ["Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20626", "l": "2 Fe(III)-[cytochrome c3] + H2 => 2 Fe(II)-[cytochrome c3] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29902", "l": "ATP + D-xylose(out) + H2O <=> ADP + D-xylose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10288", "l": "H2O + L-rhamnono-1,4-lactone = H(+) + L-rhamnonate", "d": []}, {"i": "EC:3.1.1.65", "l": "\"L-rhamnono-1,4-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018901", "l": "5-HEDH dehydrogenates 5(S)-Hp-18(R)-HpEPE to 18(R)-RvE2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31436", "l": "(2E,6E)-farnesyl diphosphate => (+)-alpha-santalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51482", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20498", "l": "a 2-arylethylamine + acetyl-CoA => an N-acetyl-2-arylethylamine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18530", "l": "3-methylbutanol + NAD(+) => 3-methylbutanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50253", "l": "an acyl-CoA + H(+) + malonyl-CoA => a 3-oxoacyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39873", "l": "1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53399", "l": "a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] <=> 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64153", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28565", "l": "D-alanine + pyridoxal 5'-phosphate <=> pyridoxamine 5'-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653957", "l": "Rag dimer formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18153", "l": "2 GTP + H(+) = diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate", "d": []}, {"i": "EC:2.7.7.45", "l": "\"guanosine-triphosphate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16567", "l": "3-(imidazol-5-yl)pyruvate + L-glutamate => 2-oxoglutarate + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24178", "l": "[ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] => [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25161", "l": "2-oxoglutarate + L-ornithine => L-glutamate + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56223", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72697", "l": "Start codon recognition (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209221", "l": "Assembly of the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009977", "l": "proton motive force dependent protein transmembrane transporter activity", "d": ["Catalysis of the transfer of proteins from one side of a membrane to the other. Transportation is dependent on pH gradient across the membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166038", "l": "GPI-bound CD14 binds LPS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72707", "l": "GDP-beta-L-fucose(in) + GMP(out) = GDP-beta-L-fucose(out) + GMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46563", "l": "episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23139", "l": "a primary amine + S-adenosyl-L-methionine <=> a methylated primary amine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617207", "l": "SPI1 (PU.1), CEBPA and DEK bind the promoter of the CSF3R (G-CSFR) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58378", "l": "decanal + H(+) + NADPH => decan-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58768", "l": "1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043961", "l": "succinyl-CoA:(R)-citramalate CoA-transferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007882", "l": "IL1F10 is cleaved (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949413", "l": "HTMLYS translocates from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9646468", "l": "mTORC1 binds RHEB:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28264", "l": "3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP => 3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874849", "l": "CREBRF binds CREB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12383", "l": "L-2,4-diaminobutanoate + pyruvate <=> L-alanine + L-aspartate 4-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26495", "l": "chloride + FADH2 + L-tryptophan + O2 => 7-chloro-L-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37197", "l": "1-octadecanoyl-sn-glycero-3-phosphate + CoA => octadecanoyl-CoA + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28957", "l": "aldehydo-D-glucuronate(out) + H(+)(out) => aldehydo-D-glucuronate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802932", "l": "Dissociation of BRAF/RAF fusion complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047685", "l": "amine sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50220", "l": "(S)-demethyl-4-deoxygadusol = (R)-demethyl-4-deoxygadusol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050212", "l": "progesterone 11-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + O2 + progesterone = 11alpha-hydroxyprogesterone + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222093", "l": "BRD7 binds TP53 and EP300 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5669013", "l": "EDA-3 binds EDA2R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19279", "l": "AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl) => ATP + L-pyrrolysine + tRNA(Pyl)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30784", "l": "D-glyceraldehyde + H2O + NAD(+) => (R)-glycerate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25112", "l": "H2O + pyridoxine 5'-phosphate = phosphate + pyridoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27824", "l": "acetate + L-homocysteine => hydrogen sulfide + O-acetyl-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985201", "l": "ABCE1 binds RNASEL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632668", "l": "SMO translocates to the cilium (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944263", "l": "Association of procollagen type II (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61932", "l": "(S)-miconazole(in) + ATP + H2O = (S)-miconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8980691", "l": "RHOA GEFs activate RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.1", "l": "\"pepsin A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0016723", "l": "oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction in which the metal ion is reduced and NAD+ or NADP+ acts as an electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50039", "l": "choloyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428534", "l": "Recruitment of Profilin by Ena/VASP proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614591", "l": "Excess cysteine yields lanthionine and H2S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32700", "l": "(2E,6E)-farnesyl diphosphate => beta-sesquiphellandrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57269", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP => GMP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.098124162625822", "identifiers": [{"i": "GO:0015101", "l": "organic cation transmembrane transporter activity", "d": ["Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69735", "l": "phenylsuccinate + succinyl-CoA = 2-phenylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18681", "l": "phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": []}, {"i": "EC:2.5.1.7", "l": "\"UDP-N-acetylglucosamine 1-carboxyvinyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41305", "l": "(4R)-hydroxysphinganine + dodecanoate => H2O + N-dodecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17372", "l": "glycyrrhizin + H2O <=> 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-481044", "l": "Surface deployment of platelet alpha granule membrane components (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688797", "l": "ATXN3 family cleave Ub chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59331", "l": "D-xylono-1,5-lactone + H2O <=> D-xylonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3785768", "l": "MRN complex binds DNA double strand breaks (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9770141", "l": "Formation of the Spliceosomal C* complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380294", "l": "Loss of C-Nap-1 from centrosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33071", "l": "D-glucose 6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate", "d": []}, {"i": "EC:4.2.3.124", "l": "\"2-deoxy-scyllo-inosose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62942", "l": "acetate + cytosine + H(+) => H2O + N(4)-acetylcytosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404200", "l": "IGF1,2 binds IGF1R (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004643", "l": "phosphoribosylaminoimidazolecarboxamide formyltransferase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9645598", "l": "RRAGC,D hydrolyzes GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47669", "l": "H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) => 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54601", "l": "2-oxoglutarate + O2 + octanoyl-CoA => 2-hydroxyoctanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350745", "l": "Release of Calumenin  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211924", "l": "CYP4B1 12-hydroxylates ARA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36391", "l": "cholesterol + NADP(+) = desmosterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937613", "l": "CRHBP binds CRH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29987", "l": "adenosine(in) + H(+)(in) = adenosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37538", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60182", "l": "ADP + D-fructose(in) + H(+) + phosphate => ATP + D-fructose(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35142", "l": "(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O <=> CO2 + 2 CoA + demethoxycurcumin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55725", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.56", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451366", "l": "Activation of p38MAPK by DSCAM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62412", "l": "(E)-feruloyl-CoA + H2O = acetyl-CoA + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000120", "l": "CBLIF binds RCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72519", "l": "2 H(+) + NADH + O2 + phenazine-1,6-dicarboxylate = 6-hydroxyphenazine-1-carboxylate + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768762", "l": "NPAS4 gene transcription in non-neuronal cells is repressed by REST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56511", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67240", "l": "(R)-S-adenosyl-L-methionine + H2O = adenosine + H(+) + L-methionine", "d": []}, {"i": "EC:3.13.2.3", "l": "\"(R)-S-adenosyl-L-methionine hydrolase (adenosine-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69708", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphinganine + H2O => beta-D-galactose + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676589", "l": "RANKL,sRANKL trimer binds RANK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987214", "l": "p-STAT3 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39728", "l": "a sphingomyelin(in) => a sphingomyelin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692867", "l": "HRH3 binds pitosilant (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64987", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.82", "l": "\"malate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "64.855413419593077", "identifiers": [{"i": "GO:0008509", "l": "monoatomic anion transmembrane transporter activity", "d": ["Enables the transfer of a negatively charged ion from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-166214", "l": "FA anion flip-flops to the opposite surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1302698", "l": "PRLR associates with JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014293", "l": "RAC2 GDIs block activation of RAC2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63944", "l": "a fatty acyl-CoA + sphinga-4E,14Z-dienine = an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38970", "l": "an N-acylsphing-4-enine(in) + ATP + H2O <=> ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23240", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18570", "l": "an aromatic aldehyde + H2O + O2 => an aromatic carboxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58813", "l": "ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate => AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917841", "l": "Acidification of Tf:TfR1 containing endosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50226", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42886", "l": "(R)-3-phosphomevalonate + ADP + H(+) => (R)-mevalonate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9656893", "l": "OPN1MW binds 11cRAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034792", "l": "hypophosphite dioxygenase activity", "d": ["Catalysis of the reaction: hypophosphite + 2-oxoglutarate + O2 = succinate + phosphite + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71061", "l": "L-arginine(out) + L-leucine(in) => L-arginine(in) + L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167429", "l": "The receptor:G-protein complex  binds GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40593", "l": "CoA + decanedioate + H(+) => decanedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685830", "l": "TUBB binds colchicine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40250", "l": "H2O + rhodomycin D <=> 10-carboxy-13-deoxycarminomycin + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60486", "l": "cyclic CMP-UMP + 2 diphosphate => CTP + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50678", "l": "N-terminal L-aspartyl-[protein] + NH4(+) => H(+) + H2O + N-terminal L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977271", "l": "Expression of EBF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0000828", "l": "inositol hexakisphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67625", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60765", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone => cinerin II + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047822", "l": "hypotaurine dehydrogenase activity", "d": ["Catalysis of the reaction: H+ + hypotaurine + NADPH + O2 = H2O + NADP+ + taurine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73533", "l": "CTP(in) + UTP(out) => CTP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981621", "l": "C3 convertases spontaneously dissociate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72185", "l": "mRNA polyadenylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032767", "l": "copper-dependent protein binding", "d": ["Binding to a protein or protein complex, in the presence of copper."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48765", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) => 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033836", "l": "flavonol 7-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 7-O-beta-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55449", "l": "a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13428", "l": "a pyrimidine ribonucleoside 5'-phosphate + H2O <=> a pyrimidine nucleobase + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418904", "l": "A1 and A3 receptors bind adenosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60125", "l": "pre-sodorifen diphosphate => diphosphate + sodorifen", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220982", "l": "NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222346", "l": "AhpC reduces H2O2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21255", "l": "(S)-2-hydroxyglutarate + A <=> 2-oxoglutarate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11546", "l": "H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine => H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71026", "l": "L-leucine(in) + L-phenylalanine(out) <=> L-leucine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64900", "l": "H2O + UTP = H(+) + phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39072", "l": "dodecanedioyl-CoA + O2 => (2E)-dodecenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213239", "l": "Formation of MHC II alpha beta heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30059", "l": "(S)-dihydroorotate + fumarate = orotate + succinate", "d": []}, {"i": "EC:1.3.98.1", "l": "\"dihydroorotate oxidase (fumarate)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678998", "l": "Endosomal TLRs pass through the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052674", "l": "ent-pimara-9(11),15-diene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-9(11),15-diene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0030292", "l": "protein tyrosine kinase inhibitor activity", "d": ["Stops, prevents or reduces the activity of a protein tyrosine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050125", "l": "N-benzyloxycarbonylglycine hydrolase activity", "d": ["Catalysis of the reaction: N-benzyloxycarbonylglycine + H2O + H+ = benzyl alcohol + CO2 + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21816", "l": "a D-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41203", "l": "1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809010", "l": "COPI vesicle uncoating (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102589", "l": "cyanidin 3-O-glucoside 3'',6''-O-dimalonyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + malonyl-CoA(5-) <=> cyanidin 3-O-(3''', 6''-O-dimalonyl-beta-glucopyranoside) + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109701", "l": "PDPK1 binds PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37903", "l": "6-hydroxytryprostatin B + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + tryprostatin A", "d": []}, {"i": "EC:2.1.1.293", "l": "\"6-hydroxytryprostatin B O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70534", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198669", "l": "p38MAPK phosphorylates MSK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939201", "l": "ESR dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69256", "l": "H2O + progoitrin = (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69329", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate => 5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29382", "l": "dGMP + H2O <=> 2'-deoxyguanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3266557", "l": "Factor I cleaves iC3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73578", "l": "(E,E)-piperate + ATP + H(+) <=> (E,E)-piperoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.110", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53419", "l": "8-amino-8-demethylriboflavin + S-adenosyl-L-methionine <=> 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045438", "l": "delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity", "d": ["Catalysis of the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine from constituent amino acids and ATP in the presence of magnesium ions and dithioerythritol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693783", "l": "NAALADases hydrolyse NAAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190829", "l": "Lysosomal degradation of gap junction plaques (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29454", "l": "H2O + phosphonate <=> H2 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66343", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21319", "l": "H2O + phorbol 12,13-dibutanoate <=> butanoate + H(+) + phorbol 13-butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10613", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27301", "l": "2-formylbenzoate + H2O + NAD(+) <=> 2 H(+) + NADH + phthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36681", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH => dTDP-6-deoxy-alpha-D-allose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482772", "l": "Release of platelet cytosolic components (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43133", "l": "N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187828", "l": "Translocation of p21 to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75838", "l": "(5S)-hydroperoxy-(6E,8Z)-octadecadienoate + 2 glutathione <=> (5S)-hydroxy-(6E,8Z)-octadecadienoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16778", "l": "ATP + H2O + K(+)(out) => ADP + H(+) + K(+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810376", "l": "ING2 binds PI5P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.-.-", "l": "\"Oxidizing metal ions\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16602", "l": "L-aspartate => fumarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72277", "l": "oxalate(out) + sulfate(in) => oxalate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375138", "l": "CDO binds BOC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62398", "l": "(S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1S,2S)-pseudoephedrine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57266", "l": "GDP + glycolate + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.98", "l": "\"4-hydroxy-3-polyprenylbenzoate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686587", "l": "ABL1 phosphorylates RAD52 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804191", "l": "TP53 binds the PRDM1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391934", "l": "DP2 receptor can bind PGD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21264", "l": "A + glycolate = AH2 + glyoxylate", "d": []}, {"i": "EC:1.1.99.14", "l": "\"glycolate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176298", "l": "Activation of claspin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706319", "l": "Active FLT3 binds to SLA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45824", "l": "H(+) + L-serine = CO2 + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018606", "l": "benzenesulfonate dioxygenase activity", "d": ["Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 + H+ = NAD+ + HSO3(-) + 4-methylcatechol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953013", "l": "E2F7 binds E2F8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63469", "l": "all-trans-octaprenol + ATP => ADP + all-trans-octaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23801", "l": "H2O + L-methionine => 2-oxobutanoate + methanethiol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59595", "l": "ATP + beta-alanine + L-arginine <=> ADP + beta-alanyl-L-arginine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928660", "l": "ADAM10 cleaves EFNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218811", "l": "DOCK180:ELMO binds CRK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.53", "l": "\"endopeptidase La\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31049", "l": "CO2 + NADH + propanoyl-CoA => (S)-methylmalonate semialdehyde + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41344", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58241", "l": "H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] => ADP-D-ribose + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614614", "l": "Cysteine is degraded to serine and H2S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68798", "l": "alpha-D-glucose + D-glucose => D-maltose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65232", "l": "3-hydroxydodecanoyl-CoA + H2O = 3-hydroxydodecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11445", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73229", "l": "(3R)-citramalate(out) + sulfate(in) => (3R)-citramalate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58981", "l": "citral + H2O + O2 => 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683888", "l": "LMCD1 binds GATA6, sequestering it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67958", "l": "(R)-lactate + chloride + H(+) => (S)-2-chloropropanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.6", "l": "\"channel-conductance-controlling ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53630", "l": "(2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73288", "l": "(2S)-naringenin + S-adenosyl-L-methionine => (2S)-naringenin 4'-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62650", "l": "(5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate => (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42009", "l": "5alpha-pregnan-20beta-ol-3-one + NAD(+) => 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452122", "l": "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848316", "l": "IL36 binds IL1RL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928578", "l": "EPH receptors autophosphorylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002114", "l": "interleukin-33 receptor activity", "d": ["Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36358", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74406", "l": "2 (S)-lactate(in) + prostaglandin D2(out) <=> 2 (S)-lactate(out) + prostaglandin D2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204549", "l": "Caveolin-1 binds Basigin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44441", "l": "a 1,3-diacylglycerol + a 1-acylglycerol => a triacylglycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27533", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (3S,6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51447", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine <=> H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019161", "l": "diamine transaminase activity", "d": ["Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018745", "l": "epoxide hydrolase A activity", "d": ["Catalysis of the hydrolysis of the ether in chloro-, bromo- or hydroxyepoxypropane to produce a chloro- or bromopropane diol or glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71091", "l": "dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) = dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018813", "l": "trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity", "d": ["Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E)-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036011", "l": "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (b branch) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42979", "l": "L-tryptophan <=> 2-aminoprop-2-enoate + indole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11032", "l": "(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate + H(+)", "d": []}, {"i": "EC:5.5.1.7", "l": "\"chloromuconate cycloisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33360", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54186", "l": "a carboxylate + an aromatic L-alpha-amino acid => an N-acyl-aromatic L-alpha-amino acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26208", "l": "4-nitrophenol + H(+) + NADPH + O2 <=> 4-nitrocatechol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61510", "l": "peonidin 3-O-beta-D-glucoside + UDP => peonidin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790994", "l": "DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14099", "l": "L-phenylalanine + oxaloacetate => 3-phenylpyruvate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696482", "l": "CTF1 binds LIFR:JAKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55311", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981539", "l": "C3b binds to cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9671145", "l": "DKC1 binds SHQ1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69522", "l": "H(+) + N-acetyl-D-galactosaminate => H2O + N-acetyl-D-galactosamino-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467436", "l": "AGRN binds Integrins alphaVbeta1 (Other beta1-containing integrins) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43197", "l": "adenosine(4) in tRNA(His) + S-adenosyl-L-methionine => 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36843", "l": "(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39331", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20261", "l": "3,5,7-trioxododecanoyl-CoA = CO2 + CoA + olivetol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34596", "l": "H(+) + isopentadecanoyl-CoA + L-serine => 3-dehydro-15-methylhexadecasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44864", "l": "a triacyl-sn-glycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10256", "l": "[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O = [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": []}, {"i": "EC:2.7.9.5", "l": "\"phosphoglucan, water dikinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853444", "l": "AURKA phosphorylates PHLDA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665761", "l": "FMNL3 binds RHOC:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.418", "l": "\"plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39242", "l": "(2E)-triacontenoyl-CoA + H(+) + NADPH <=> NADP(+) + triacontanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68603", "l": "ORC5 binds ORC2:ORC3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23002", "l": "(R)-4-dehydropantoate + H(+) + NADH => (R)-pantoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18159", "l": "ADP + H(+) + phosphoenolpyruvate => ATP + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37219", "l": "A + D-valine + H2O = 3-methyl-2-oxobutanoate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57774", "l": "4-methylcatechol + NAD(+) + nitrite => 3-nitrotoluene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103080", "l": "methylthiopropylmalate isomerase activity", "d": ["Catalysis of the reaction: 2-(3-methylthiopropyl)malate(2-) <=> 3-(3'-methylthio)propylmalate."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004788", "l": "thiamine diphosphokinase activity", "d": ["Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45556", "l": "H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63911", "l": "ATP + H2O + pravastatin(in) <=> ADP + H(+) + phosphate + pravastatin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64597", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose => an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603554", "l": "NTRK3(496-641):NELFB translocates to mitochondrion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35965", "l": "fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8963864", "l": "CUBN dissociates from 25(OH)D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48621", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008046", "l": "axon guidance receptor activity", "d": ["Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852331", "l": "GTSE1 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38925", "l": "a ubiquinol + Na(+)(out) + NAD(+) => a ubiquinone + H(+) + Na(+)(in) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15174", "l": "H(+) + H2O2 + NADPH => 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40157", "l": "22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10819", "l": "H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside <=> L-fucose + methyl beta-D-galactoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72711", "l": "cathenamine + H(+) = 4,21-dehydrogeissoschizine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0042166", "l": "acetylcholine binding", "d": ["Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13324", "l": "(R)-3,3-dimethylmalate + NAD(+) <=> 3-methyl-2-oxobutanoate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33608", "l": "(9Z)-octadecenoate + ATP + CoA => (9Z)-octadecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15183", "l": "ADP + an acyl-CoA(in) + H(+) + phosphate => an acyl-CoA(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656257", "l": "Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66607", "l": "a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O <=> a 2'-deoxyuridine in double-stranded DNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16582", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2 => 2 Fe(III)-[cytochrome c] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418925", "l": "ADORA2A,B bind Ade-Rib (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.327", "l": "\"aclacinomycin-T 2-deoxy-L-fucose transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030729", "l": "acetoacetate-CoA ligase activity", "d": ["Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54078", "l": "diphosphate + stellata-2,6,19-triene => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41653", "l": "aclacinomycin S + dTDP-2-deoxy-beta-L-fucose => 2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31712", "l": "beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106419", "l": "NAD-dependent protein lipoamidase activity", "d": ["Catalysis of the reaction: (R)-N6-lipoyl-L-lysyl-[protein] + H2O + NAD+ = 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:63640", "l": "(R)-N(6)-lipoyl-L-lysyl-[protein] + H2O + NAD(+) = 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46589", "l": "calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcidiol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17059", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP] => a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45969", "l": "androst-4-ene-3,17-dione + H(+) + NADH + O2 => 9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12161", "l": "2-deoxy-D-gluconate + NAD(+) => 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63515", "l": "biphenyl-2,2'-diol + H(+) + NADH + O2 <=> biphenyl-2,2',3-triol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55507", "l": "(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032781", "l": "WWTR1 (TAZ) binds TEAD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008193", "l": "tRNA guanylyltransferase activity", "d": ["Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9828175", "l": "Formation of the NSL complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69337", "l": "(E)-alk-1-en-1-SO-peroxol => (Z)-alkanethial oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58148", "l": "ethyl acetate + H2O = acetate + ethanol + H(+)", "d": []}, {"i": "EC:3.1.1.113", "l": "\"ethyl acetate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801195", "l": "STEAP3 binds BNIP3L (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65164", "l": "benzoyl-CoA + hexan-3-ol = CoA + hexan-3-yl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5221061", "l": "TDG excises 5-carboxylcytosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12135", "l": "ATP + Cd(2+)(in) + H2O <=> ADP + Cd(2+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432143", "l": "PECAM-1 binds PP2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22911", "l": "3',5'-cyclic AMP + H(+) + H2O <=> 3',5'-cyclic IMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805103", "l": "AURKA phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26373", "l": "[thioredoxin]-disulfide + prostamide F2alpha = [thioredoxin]-dithiol + prostamide H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48106", "l": "H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0070037", "l": "rRNA (pseudouridine) methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule."]}, {"i": "REACT:R-HSA-6790906", "l": "EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35625", "l": "gamma-D-glutamyl-D-glutamate + NH4(+) => D-glutamate + D-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59666", "l": "D-cellopentaono-1,5-lactone + H2O2 => D-cellopentaose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446694", "l": "IRAK4 phosphorylates IRAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23717", "l": "(3Z)-dodecenoyl-CoA => (2E)-dodecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1500804", "l": "Peroxynitrite is reduced by AhpE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655170", "l": "RCHY1 monoubiquitinates POLH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001729", "l": "ceramide kinase activity", "d": ["Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004508", "l": "steroid 17-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111930", "l": "Adenylate cyclase produces cAMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41500", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60937", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983158", "l": "Trimming of peptides in ER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948034", "l": "FGR binds LDL:LRP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706399", "l": "RHOBTB3 hydrolyzes ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38811", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21765", "l": "heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018758", "l": "RHOH binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167098", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25049", "l": "(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O <=> (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530573", "l": "CREG(CR1L) binds to surface-bound C3 convertases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043800", "l": "hexulose-6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187261", "l": "COLEC12 (SCARA4) binds ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33536", "l": "H2O + lanosteryl ester => a carboxylate + H(+) + lanosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186780", "l": "Degradation of Ub-SMAD7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849882", "l": "SALMs 1-4 bind reticulon 3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39313", "l": "(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+) => (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39503", "l": "(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH = (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534096", "l": "METAP1/2 demethylates GNAT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451310", "l": "Activation of Edited Kainate receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18488", "l": "6-acetyl-D-glucose + H2O <=> acetate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796368", "l": "RIPK1 binds STUB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17719", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5-trisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58029", "l": "5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH => a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990446", "l": "U1 snRNP binding", "d": ["Binding to a U1 small nuclear ribonucleoprotein particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37141", "l": "1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55676", "l": "chorismate + NH4(+) = (2S)-2-amino-4-deoxychorismate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10146", "l": "a ribonucleoside + phosphate => a ribonucleoside 3'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-383190", "l": "HCO3- transport through ion channel (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2002466", "l": "Formation of allysine by LOX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64046", "l": "CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine => (13Z)-docosenoyl-CoA + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432010", "l": "Aquaporin-1 passively transports water into cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.535054500181104", "identifiers": [{"i": "GO:0016855", "l": "racemase and epimerase activity, acting on amino acids and derivatives", "d": ["Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid."]}, {"i": "EC:5.1.1.-", "l": "\"Acting on amino acids and derivatives\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45564", "l": "2-epi-5-epi-valiolone = 5-epi-valiolone", "d": []}, {"i": "EC:5.1.3.33", "l": "\"2-epi-5-epi-valiolone epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35904", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23731", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 <=> A + H2O + prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202291", "l": "Activation of Lck (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32359", "l": "1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)", "d": []}, {"i": "EC:2.7.1.151", "l": "\"inositol-polyphosphate multikinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.8", "l": "\"iodide peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015371", "l": "galactose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33821", "l": "3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate => 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25288", "l": "4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23230", "l": "H2O + N(6)-hydroxy-L-lysine + NADP(+) => L-lysine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45317", "l": "H(+) + NADPH + prostaglandin D2 => 11beta-prostaglandin F2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56558", "l": "delta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10827", "l": "(S)-malate + NADP(+) <=> H(+) + NADPH + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28651", "l": "inosine + O2 = 9-riburonosylhypoxanthine + H(+) + H2O", "d": []}, {"i": "EC:1.1.3.28", "l": "\"nucleoside oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050359", "l": "tropomyosin kinase activity", "d": ["Catalysis of the reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13539", "l": "2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+) => (2R)-3-phosphoglycerate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4649028", "l": "TLE forms non-functional complexes with AES (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.59", "l": "\"caspase-6\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74718", "l": "Internalisation of the insulin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24509", "l": "NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.6", "l": "\"DNA ligase (ATP or NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31323", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.270", "l": "\"mannosylglucosyl-3-phosphoglycerate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29489", "l": "cis-muurola-3,5-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11183", "l": "ATP + L-asparagine + tRNA(Asn) <=> AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18738", "l": "ATP + H2O + hydrogenselenide => AMP + 2 H(+) + phosphate + selenophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016422", "l": "mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61305", "l": "N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose => H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24876", "l": "H2O + O-phospho-D-serine <=> D-serine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54079", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + stellata-2,6,19-triene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49763", "l": "EDTA + FMNH2 + O2 <=> ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53905", "l": "ATP + L-threonyl-[tau protein] => ADP + H(+) + O-phospho-L-threonyl-[tau protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56209", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] => 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694583", "l": "ABHD4 hydrolyses NAPE (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32299", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADH = 2 diphosphate + NAD(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004768", "l": "stearoyl-CoA 9-desaturase activity", "d": ["Catalysis of the reaction: 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690152", "l": "USP5 cleaves polyubiquitin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683664", "l": "GSK3 phosphorylates Nucleoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564169", "l": "Collagen type VIII degradation by MMP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781905", "l": "ZRANB1 binds APC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000310", "l": "AURKA phosphorylates PLK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37836", "l": "aklavinone + H(+) + NADPH + O2 => epsilon-rhodomycinone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803892", "l": "SFN dimer binds BAX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17884", "l": "H2O + N-sulfo-D-glucosamine <=> D-glucosamine + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35557", "l": "4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid => cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004686", "l": "elongation factor-2 kinase activity", "d": ["Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69834", "l": "campestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-deoxycathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40300", "l": "6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58531", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH <=> (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18422", "l": "acetyl-CoA + chloramphenicol => chloramphenicol 3-acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682011", "l": "LC3 binds ATG7 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372559", "l": "aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6804266", "l": "CHEK2 phosphorylates TTC5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3204311", "l": "AOX1 oxidises PXL to PDXate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2545253", "l": "Deacetylation of cohesin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849102", "l": "SRMS phosphorylates PTK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44598", "l": "a fatty acid + H(+) + holo-[ACP] => a fatty acyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65006", "l": "AMP + decanoyl-[ACP] + diphosphate => ATP + decanoate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0008195", "l": "phosphatidate phosphatase activity", "d": ["Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52517", "l": "trans-4-hydroxy-L-proline + ubiquinone-10 => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72180", "l": "Cleavage of mRNA at the 3'-end (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202472", "l": "Translocation of TRAF6 to CBM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004613", "l": "phosphoenolpyruvate carboxykinase (GTP) activity", "d": ["Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57730", "l": "CO2 + itaconate => H(+) + trans-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31760", "l": "dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682992", "l": "KDM4A,B bind H4K20Me2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4088134", "l": "PLK1 phosphorylates FOXM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692315", "l": "OX40L binds OX40 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32936", "l": "a cardiolipin + H2O => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23480", "l": "2-methylene-3-methylsuccinate = dimethylmaleate", "d": []}, {"i": "EC:5.3.3.6", "l": "\"methylitaconate Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042934", "l": "achromobactin transmembrane transporter activity", "d": ["Enables the transfer of achromobactin, a citrate siderophore, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "76.652932776586212", "identifiers": [{"i": "GO:0015662", "l": "P-type ion transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11399", "l": "5-methyldeoxycytidine 5'-phosphate + ATP <=> 5-methyldeoxycytidine diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64872", "l": "D-ribulose 1-phosphate = dihydroxyacetone phosphate + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16253", "l": "(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) = H(+) + NADH + phenanthrene-3,4-diol", "d": []}, {"i": "EC:1.3.1.49", "l": "\"cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26114", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018798", "l": "RHOV binds GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6795290", "l": "TORC2 complex phosphorylates SGK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33965", "l": "ADP + isopentenyl diphosphate => ATP + isopentenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419861", "l": "Melanospin is stimulated by light (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63151", "l": "H2O + N-(9Z-octadecenoyl)-taurine <=> (9Z)-octadecenoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694549", "l": "RTC completes synthesis of the minus strand genomic RNA complement (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61352", "l": "ATP + H2O + riboflavin(in) = ADP + H(+) + phosphate + riboflavin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693111", "l": "RHOF auto-activates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62098", "l": "2-(9Z-octadecenoyl)-glycerol + phosphate => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71494", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) <=> an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59502", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate => 5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22269", "l": "ATP + streptomycin => ADP + H(+) + streptomycin 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13134", "l": "CTP + di-trans,poly-cis-dolichol => a dolichyl phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13492", "l": "(S)-canadine + H(+) + 2 O2 <=> berberine + 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13170", "l": "maleate => fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070087", "l": "chromo shadow domain binding", "d": ["Binding to a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37433", "l": "2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine => 12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46207", "l": "androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213201", "l": "Formation of collagen fibres (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193684", "l": "p62 recruits an atypical PKC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21445", "l": "3-(2-hydroxyphenyl)propanoate + NAD(+) => H(+) + NADH + trans-2-coumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27549", "l": "anthranilate + FADH2 + O2 <=> 3-hydroxyanthranilate + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50035", "l": "H2O + hexadecanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63557", "l": "dynorphin A-(1-13) + H2O => dynorphin A-(1-12) + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400256", "l": "CRY:PER heterodimer binds the BMAL1:CLOCK/NPAS2 heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14321", "l": "morphine + NADP(+) = H(+) + morphinone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32596", "l": "7-isopropyl-4-methyloxepan-2-one + H2O => 6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794569", "l": "Apical transport of Cipro to extracellular space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62662", "l": "(2'R)-atrovenetin => 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373734", "l": "Nephrin interacts with Podocin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57768", "l": "2-nitrotoluene + NADH + O2 = 3-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.5", "l": "\"3-oxoacid CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627107", "l": "XIAP binds CASP7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047831", "l": "D-ornithine 4,5-aminomutase activity", "d": ["Catalysis of the reaction: D-ornithine = (2R,4S)-2,4-diaminopentanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66206", "l": "(2E)-heptenoyl-CoA + H2O2 => heptanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20375", "l": "AMP + diphosphate + propanoyl-CoA => ATP + CoA + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204873", "l": "Interaction of Tie2 and Shp2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603719", "l": "Protein tyrosine phosphatases dephosphorylate NTRK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44850", "l": "CoA + O-(9Z)-tetradecenoyl-(R)-carnitine => (9Z)-tetradecenoyl-CoA + (R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20973", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine => 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16105", "l": "a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51589", "l": "isopyridoxal + NAD(+) => 5-pyridoxolactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761815", "l": "AcK-NFE2L2 and ATF4 bind the SLC7A11 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645481", "l": "TIFA oligomerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389348", "l": "Activation of Rac1 by pVav1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.n4", "l": "\"ankyrin-repeat-histidine dioxagenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65160", "l": "benzoyl-CoA + hexan-2-ol = CoA + hexan-2-yl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421447", "l": "protoporphyrin IX + Fe++ => heme + 2 H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48723", "l": "aurachin B + H2O + NAD(+) <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38020", "l": "(9Z)-octadecenoyl-CoA + 1-decanoylglycerol => 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166869", "l": "TRAF6 binds MEKK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41908", "l": "(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62886", "l": "2 (M)-viriditoxin + 2 H2O => O2 + 4 semiviriditoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853898", "l": "VENTX binds the CSF1R (M-CSF-R) gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857555", "l": "EGFR phosphorylates GPNMB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72951", "l": "butanoate(out) + 2 Na(+)(out) = butanoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75594", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate <=> (11S)-hydroxy-(9S,10S)-epoxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013158", "l": "CDC42 GDIs block activation of CDC42 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72250", "l": "(R)-noradrenaline + S-adenosyl-L-methionine <=> (R)-normetanephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371591", "l": "Trimerization of cytosolic HSF1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686625", "l": "LAIR1 binds collagen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58037", "l": "8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => 8-epi-inunolide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21477", "l": "[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050298", "l": "stizolobinate synthase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39521", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1671687", "l": "PRLR activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67405", "l": "gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42352", "l": "(R)-nicotine + A + H2O = (R)-6-hydroxynicotine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983427", "l": "Expression of peptide bound class I MHC on cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41549", "l": "8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine => 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40559", "l": "dTDP-beta-L-evernosamine + NADPH + O2 = dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374686", "l": "L1 interaction with Integrins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008903", "l": "hydroxypyruvate isomerase activity", "d": ["Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10423", "l": "pyruvate + taurine <=> L-alanine + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102233", "l": "crotonaldehyde redutase activity", "d": ["Catalysis of the reaction: (cis)-crotonaldehyde + NADPH + H+ <=> butanal + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26443", "l": "a ubiquinone + ethanol => a ubiquinol + acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39993", "l": "CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine => (4R)-hydroxyeicosasphinganine + a fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57861", "l": "(E)-6-hydroxyferuloyl-CoA => CoA + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48891", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione <=> (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21636", "l": "(E)-4-coumarate + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.126", "l": "\"hydroxycinnamate 4-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858428", "l": "FCAMR binds IgA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2995330", "l": "COX10 transforms heme to heme O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19083", "l": "a halide anion + a primary alcohol + H(+) => 1-haloalkane + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20010", "l": "2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose => H(+) + linamarin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70401", "l": "CoA + H(+) + N-tetracosanoyl-3-oxosphinganine => 3-oxosphinganine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.194", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75080", "l": "Formation of AT-AC A complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29632", "l": "D-maltotetraose + H2O => alpha-D-glucose + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218847", "l": "PAK2 binds NCK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198599", "l": "AKT phosphorylates MDM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65509", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2 => H2O2 + NH4(+) + pre-mycofactocin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21378", "l": "(S)-4-hydroxymandelate + CO2 => 3-(4-hydroxyphenyl)pyruvate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.25", "l": "\"1,4-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43149", "l": "adenosine(9) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63787", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22965", "l": "H(+) + L-ornithine => CO2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20987", "l": "a sphingomyelin + H2O <=> an N-acylsphing-4-enine 1-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610195", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN2D (GRIN2D) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851436", "l": "CFHR dimers bind C3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42103", "l": "ATP + carbamoyl phosphate + H2O + kanamycin A <=> 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11527", "l": "5beta-cholestan-3-one + NADP(+) <=> cholest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38417", "l": "(9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672957", "l": "PP2A dephosphorylates KSR1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41657", "l": "dihydrosanguinarine + NADP(+) => NADPH + sanguinarine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389381", "l": "Gads binds CD28 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4608855", "l": "PRICKLE1 is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41906", "l": "(3R)-hydroxyhexadecanoyl-[ACP] + NADP(+) => 3-oxohexadecanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61380", "l": "2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O = 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16970", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008116", "l": "prostaglandin-I synthase activity", "d": ["Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852200", "l": "Inactivation of LCK by PTPN22 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015626", "l": "L-diaminopimelate transmembrane transporter activity", "d": ["Enables the transfer of L-diaminopimelate from one side of a membrane to the other. L-diaminopimelate is the L-enantiomer anion of 2,6-diaminoheptanedioic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.3.-", "l": "\"Linked to the hydrolysis of diphosphate\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601926", "l": "RNA polymerase II polymerizes primary piRNA transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63849", "l": "2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2 => 2 3',4'-dihydroxyaurone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45154", "l": "3-oxopropanoyl-CoA + methanethiol => 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24182", "l": "CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] => 2-hydroxyisobutanoyl-CoA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9613497", "l": "Unwinding DNA for the nascent transcript (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65870", "l": "1,17beta-dihydroxyandrostan-3-one => Delta(1)-dihydrotestosterone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75504", "l": "glycocholate(out) + n H(+)(out) => glycocholate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034277", "l": "ent-cassa-12,15-diene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63631", "l": "ATP + hexadecanoate + holo-[ACP] <=> AMP + diphosphate + hexadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9725855", "l": "NR3C2 binds NR3C2 antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798743", "l": "Exocytosis of secretory granule membrane proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202966", "l": "Caspase mediated cleavage of HIP-55 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1878002", "l": "XYLTs transfer Xyl to core protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56655", "l": "12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) <=> 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15550", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30341", "l": "CO2 + tryptamine => H(+) + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14965", "l": "an acyl phosphate + H2O = a carboxylate + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.7", "l": "\"acylphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018738", "l": "S-formylglutathione hydrolase activity", "d": ["Catalysis of the reaction: S-formylglutathione + H2O = formate + glutathione + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48794", "l": "alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => GDP-beta-L-fucose + Lc4Cer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17089", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429529", "l": "Thrombin binding to GP1b:IX:V (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60833", "l": "a 5'-end triphospho-guanosine in mRNA + H2O => a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17272", "l": "macrocin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + tylosin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265456", "l": "NPC1L1 binds ezetimibe (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14454", "l": "4-(phosphooxy)-L-threonine + NAD(+) => (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15406", "l": "(3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) => [(3R)-hydroxybutanoate](n+1) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "61.311492862095925", "identifiers": [{"i": "GO:0016765", "l": "transferase activity, transferring alkyl or aryl (other than methyl) groups", "d": ["Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42147", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679044", "l": "FKBP1A binds sirolimus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73105", "l": "luteolin 4',7-dimethyl ether + S-adenosyl-L-homocysteine => diosmetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55586", "l": "an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607744", "l": "MALT1 binds BCL10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052719", "l": "apurinic/apyrimidinic endoribonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a ribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-ribose phosphate and 3'-hydroxyl ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48329", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose => GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653974", "l": "Ragulator binds Rag dimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012835", "l": "GDIs block activation of RHOA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198813", "l": "GSTO dimers reduce DeHA to AscH- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-571324", "l": "IRAK2 binds to p-IRAK4:MyD88:activated TLR7 or 21 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446364", "l": "Migfilin interacts with VASP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015636", "l": "short-chain fatty acid transmembrane transporter activity", "d": ["Enables the transfer of short-chain fatty acids from one side of a membrane to the other. A short-chain fatty acid is a fatty acid with an aliphatic tail of less than 6 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372980", "l": "succinylCoA + GDP + Pi <=> succinate + CoASH + GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399997", "l": "AKT1 E17K mutant translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928578", "l": "EPH receptors autophosphorylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17725", "l": "(2S,3S)-2-methylcitrate = 2-methyl-cis-aconitate + H2O", "d": []}, {"i": "EC:4.2.1.79", "l": "\"2-methylcitrate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-921155", "l": "p-STAT5 dissociates from the receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008741", "l": "ribulokinase activity", "d": ["Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60014", "l": "a tRNA with a 3' CCA end + diphosphate => a tRNA with a 3' CC end + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047307", "l": "diaminobutyrate-pyruvate transaminase activity", "d": ["Catalysis of the reaction: L-2,4-diaminobutyrate + pyruvate = L-alanine + L-aspartate 4-semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65305", "l": "2-oxoglutarate + O2 + verruculide A => chrodrimanin T + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69018", "l": "5beta-pregnan-3,20-dione + H(+) + NADPH => 3alpha-hydroxy-5beta-pregnan-20-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42650", "l": "(2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+) => (2,5-ethylene furandicarboxylate)(n) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49318", "l": "(5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31971", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.146", "l": "\"taxoid 14beta-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029456", "l": "RAC1 and CDC42 activate PAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033403", "l": "UUA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UUA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987043", "l": "IL22RA1 binds JAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388808", "l": "CD28 homodimer binds B7-2 monomer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044654", "l": "starch alpha-glucosidase activity", "d": ["Catalysis of the reaction: starch + H2O = alpha-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033956", "l": "beta-apiosyl-beta-glucosidase activity", "d": ["Catalysis of the reaction: 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid + H2O = a 7-hydroxyisoflavonoid + beta-D-apiofuranosyl-(1->6)-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030788", "l": "precorrin-2 C20-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H+ + precorrin-3A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368081", "l": "Expression of SREBF1 (SREBP1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112604", "l": "Phosphorylated STATs are released (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25596", "l": "2-oxoglutarate + H(+) + isochorismate <=> 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404142", "l": "atROL binds RBP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786421", "l": "CHIA hydrolyses chitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050334", "l": "thiaminase activity", "d": ["Catalysis of the reaction: H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44256", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21388", "l": "H2O + L-2-aminohexano-6-lactam = L-lysine", "d": []}, {"i": "EC:3.5.2.11", "l": "\"L-lysine-lactamase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989762", "l": "Expression of ABCB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198983", "l": "NKG2D homodimer interacting with ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052621", "l": "diguanylate cyclase activity", "d": ["Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46382", "l": "(24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5227009", "l": "ABCF1 binds EIF2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16616", "l": "acetyl-CoA + an arylamine <=> an N-acetylarylamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977605", "l": "Factor H displaces Bb (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679029", "l": "C-ter TLR7 dimer binds HCQ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13871", "l": "3-(4-hydroxyphenyl)pyruvate + CO2 + NADH => NAD(+) + prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69341", "l": "(E)-prop-1-en-1-SO-peroxol => (Z)-propanethial S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16143", "l": "3''-deamino-3''-oxonicotianamine + H(+) + NADH => 2'-deoxymugineate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655170", "l": "RCHY1 monoubiquitinates POLH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74323", "l": "O-3-hydroxybutanoyl-(R)-carnitine(in) = O-3-hydroxybutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047991", "l": "hydroxylamine oxidase activity", "d": ["Catalysis of the reaction: hydroxylamine + O2 = H2O + H+ + nitrite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65020", "l": "L-ornithine + succinyl-CoA = CoA + H(+) + N(2)-succinyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706308", "l": "Active FLT3 binds to GRB10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68091", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] <=> a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0051378", "l": "serotonin binding", "d": ["Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209303", "l": "LGS transports from the nucleus to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.18", "l": "\"1,4-alpha-glucan branching enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47145", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432129", "l": "FGR binds and phosphorylates LRP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878117", "l": "RUNX3 binds ZFHX3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533970", "l": "NID1 degradation by MMP3, 7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419843", "l": "CALCA(83-119) binds CALCR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0008553", "l": "P-type proton-exporting transporter activity", "d": ["Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45702", "l": "formaldehyde + H2O + N,N-dimethylglycine + NAD(+) => glycine betaine + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30762", "l": "5-methylcytosine + H(+) + H2O <=> NH4(+) + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3244643", "l": "STING binds cyclic GMP-AMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706323", "l": "Active FLT3 binds to SLA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54365", "l": "2 acetaldehyde => acetoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008676", "l": "3-deoxy-8-phosphooctulonate synthase activity", "d": ["Catalysis of the reaction: D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61639", "l": "ATP + CoA + isophthalate <=> AMP + diphosphate + isophthalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426209", "l": "DAG activation of TRPC channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28044", "l": "acetyl-CoA + CO2 + NADH => CoA + NAD(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938217", "l": "RUNX1 binds the SWI/SNF complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950480", "l": "Expression of annexin A2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029456", "l": "RAC1 and CDC42 activate PAK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176298", "l": "Activation of claspin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58133", "l": "A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] => AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21718", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59109", "l": "chenodeoxycholate + octyl beta-D-glucose => beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649742", "l": "Defective SLC33A1 does not transport Ac-CoA from cytosol to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3878123", "l": "Initiation of SAHF formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75241", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[protein] => acetyl-CoA + N-terminal L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66608", "l": "(tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O = GpCpCpA + H(+) + tRNA 3'-end (ribonucleotide 3'-phosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36393", "l": "desmosterol + H(+) + NADPH => cholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40785", "l": "CoA + docosanoate + H(+) => docosanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-205136", "l": "GTP-bound RAC contributes to JNK activation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27949", "l": "dopamine + H2O + O2 <=> 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9010872", "l": "SLIT2 binds Dystroglycan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592436", "l": "Initial activation of proMMP9 by MMPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66406", "l": "ADP + glutathione(out) + H(+) + phosphate + taurocholate(out) => ATP + glutathione(in) + H2O + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71746", "l": "2-oxoglutarate(out) + hexanedioate(in) <=> 2-oxoglutarate(in) + hexanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70377", "l": "CoA + H(+) + N-dodecanoyl-3-oxosphinganine => 3-oxosphinganine + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41618", "l": "D-ribose 5-phosphate + phosphate => D-ribose 2,5-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30673", "l": "2 N-acetyl-D-glucosamine => H2O + N,N'-diacetylchitobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75944", "l": "beta-alanine + L-arginine => 3-guanidinopropanoate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426489", "l": "RISC binds inexactly matching target RNAs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56924", "l": "ATP + L-threonyl-[Goodpasture antigen-binding protein] = ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32627", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22676", "l": "chlorophyllide a + H(+) + NADPH + O2 = 7(1)-hydroxychlorophyllide a + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15970", "l": "2 glutathione + H(+) + methylarsonate => glutathione disulfide + H2O + methylarsonous acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854303", "l": "TBC1D11 binds RAB6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59530", "l": "CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein] => hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879907", "l": "Tyrosine kinases phosphorylate the receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19633", "l": "(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) = (5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.11", "l": "\"L-erythro-3,5-diaminohexanoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047293", "l": "4-hydroxybenzoate nonaprenyltransferase activity", "d": ["Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66579", "l": "3'-phosphoadenylyl sulfate + 4-isopropylphenol <=> 4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72691", "l": "Formation of the 43S pre-initiation complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.5", "l": "\"haloalkane dehalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875558", "l": "RAPGEF1 binds CRK,CRKL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23964", "l": "(E)-coniferaldehyde + H2O + NADP(+) = (E)-ferulate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448678", "l": "CTSG cleaves CASP1(1-404) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710254", "l": "GSDME oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45142", "l": "CO2 + L-glutamyl-[protein] + O2 + phylloquinol => 2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.106", "l": "\"glucose-1,6-bisphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21978", "l": "[thioredoxin]-dithiol + adenosine 5'-phosphosulfate => [thioredoxin]-disulfide + AMP + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689649", "l": "BAP1 binds BRCA1:BARD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693198", "l": "RHOD binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876446", "l": "p-ULK1 phosphorylates DENND3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74419", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) = 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865774", "l": "TTLLs polyglutamylate tubulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754129", "l": "CDK6 inhibitors bind CDK6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70453", "l": "a 2'-deoxyadenosine in single-stranded DNA + acetaldehyde + CO2 + H(+) + succinate => 2-oxoglutarate + an N(1)-ethyl-2'-deoxyadenosine in single-stranded DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50428", "l": "methanethiol + S-adenosyl-L-methionine = dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.334", "l": "\"methanethiol S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56701", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 => 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36662", "l": "carbamoyl phosphate + descarbamoylnovobiocin <=> novobiocin + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33156", "l": "a 1-acyl-sn-glycero-3-phosphate + H2O => a 1-acyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168895", "l": "RNP association (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60856", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52041", "l": "L-cystine => 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210886", "l": "NEUROG3-dependent synthesis of PAX4 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877421", "l": "CTLA4 gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13512", "l": "H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP <=> diphosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624954", "l": "INPP5E translocates to the primary cilium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10421", "l": "pyruvate + taurine => L-alanine + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66807", "l": "ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034320", "l": "alcohol O-hexanoyltransferase activity", "d": ["Catalysis of the reaction: hexanoyl-CoA + an alcohol = CoA + a hexyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13811", "l": "aspulvinone H + 2 diphosphate => aspulvinone E + 2 dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0090079", "l": "translation regulator activity, nucleic acid binding", "d": ["Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22687", "l": "4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 <=> (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209924", "l": "Dopa is decarboxylated to dopamine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45847", "l": "(3R)-hydroxyoctanoyl-CoA + NADP(+) <=> 3-oxooctanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55719", "l": "(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59796", "l": "dodecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71809", "l": "an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + H(+) + nicotinamide => a 2'-deoxyguanosine in DNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675417", "l": "PEBP1 binds activated RAF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56137", "l": "2 a phenolic donor + H2O2 => 2 a phenolic radical donor + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072345", "l": "NAADP-sensitive calcium-release channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts."]}, {"i": "REACT:R-HSA-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0004972", "l": "NMDA glutamate receptor activity", "d": ["An cation channel that opens in response to binding by extracellular glutmate, but only if glycine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693575", "l": "DNA-PKcs autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102217", "l": "6-phosphoglucan, water dikinase activity", "d": ["Catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-maltodextrin = n AMP + n hydrogenphosphate + a poly-6-phosphogluco-maltodextrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400204", "l": "PPARA binds RXRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35726", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1364044", "l": "PRLR:JAK2 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32257", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+) => meso-2,6-diaminoheptanedioate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45995", "l": "(3R)-3-hydroxydecanoyl-CoA <=> (2E)-decenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33581", "l": "H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate => NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48312", "l": "benzoyl-CoA + H(+) + NADPH + O2 = 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.208", "l": "\"benzoyl-CoA 2,3-epoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60235", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22314", "l": "ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate => 5-(methylsulfanyl)-D-ribose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65863", "l": "A + Delta(1)-dihydrotestosterone + H2O <=> 17beta-hydroxyandrostan-1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72691", "l": "Formation of the 43S pre-initiation complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59889", "l": "4-chloro-L-lysine + AH2 + O2 => A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647680", "l": "CASP1 cleaves GSDMD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825564", "l": "MESP2 binds the EPHA4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42779", "l": "adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52011", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA <=> 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014467", "l": "RHOG binds effectors at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16528", "l": "2-dehydro-3-deoxy-D-galactonate + ATP <=> 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050221", "l": "prostaglandin-E2 9-reductase activity", "d": ["Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34291", "l": "2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose = 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0015379", "l": "potassium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71613", "l": "(S)-malate(out) + malonate(in) => (S)-malate(in) + malonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50613", "l": "decanal + NADP(+) => (2E)-decenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432129", "l": "FGR binds and phosphorylates LRP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68831", "l": "borneol + NAD(+) <=> camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68419", "l": "cis-(homo)2aconitate + H2O <=> (2R,3S)-iso(homo)2citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10773", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O => D-glucose + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56670", "l": "7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42985", "l": "(+)-copalyl diphosphate => diphosphate + pimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093329", "l": "EFNBs bind SDCBP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19032", "l": "3 H(+) + H2O + urea-1-carboxylate <=> 2 CO2 + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31343", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate", "d": []}, {"i": "EC:3.1.3.85", "l": "\"glucosyl-3-phosphoglycerate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983142", "l": "Formation of peptide loading complex (PLC) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44646", "l": "a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+) => a 2'-deoxyribonucleoside 5'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65426", "l": "AMP(out) + NAD(+)(in) => AMP(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0003990", "l": "acetylcholinesterase activity", "d": ["Catalysis of the reaction: acetylcholine + H2O = choline + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199299", "l": "AKT phosphorylates FOXO transcription factors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417820", "l": "P2Y9 receptor can bind to LPA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11149", "l": "4 Fe(2+) + 4 H(+) + O2 => 4 Fe(3+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17865", "l": "5,6,7,8-tetrahydropteridine + NADP(+) = 6,7-dihydropteridine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71382", "l": "D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out) <=> D-aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821486", "l": "HCFC1 binds SET1A complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65227", "l": "(1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+) <=> H(+) + NADPH + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.20", "l": "\"penicillopepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-445714", "l": "Aquaporin-3 passively transports water out of cell (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166817", "l": "Cleavage of C3 by C3 convertases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29213", "l": "H(+)(in) + inosine(out) => H(+)(out) + inosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193647", "l": "IRAK is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66685", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] => L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39233", "l": "(3R)-hydroxytriacontanoyl-CoA + NADP(+) => 3-oxo-triacontanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373717", "l": "DCC interacts with DIP13alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36340", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37488", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine => 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4167511", "l": "HLCS biotinylates ACACB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035642", "l": "histone H3R17 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to the arginine residue at position 17 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23212", "l": "H2O + N-acetyl-beta-alanine = acetate + beta-alanine", "d": []}, {"i": "EC:3.5.1.21", "l": "\"N-acetyl-beta-alanine deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54076", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + stellata-2,6,19-triene", "d": []}, {"i": "EC:4.2.3.178", "l": "\"stellata-2,6,19-triene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023163", "l": "Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42674", "l": "gamma-L-glutamyl-hercynylcysteine S-oxide + H2O => gamma-L-glutamyl-L-cysteine + hercynine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4647593", "l": "EP400 binds CDKN1A promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16104", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate <=> n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9815789", "l": "Expression of SHH in axial mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0000908", "l": "taurine dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + O2 + taurine = aminoacetaldehyde + CO2 + succinate + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56106", "l": "4,4'-diaponeurosporenal + 2 A + 3 H2O => 2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72639", "l": "1,6-dihydroxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine = 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47363", "l": "decanoate ester + H2O <=> an aliphatic alcohol + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19898", "l": "H(+) + 2 L-arginine + 3 NADPH + 4 O2 => 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50053", "l": "ATP + H2O + taurocholate(in) => ADP + H(+) + phosphate + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.232", "l": "\"15-hydroxyicosatetraenoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28028", "l": "[thioredoxin]-dithiol + UDP => [thioredoxin]-disulfide + dUDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68230", "l": "glycine(out) + Na(+)(out) => glycine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357483", "l": "RAC1 binds PAK1-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381500", "l": "Cathepsin G proteolyzes IGF:IGFBP3:ALS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57556", "l": "(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59576", "l": "anserine + H2O = beta-alanine + N(pros)-methyl-L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944219", "l": "Association of procollagen type XVI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70103", "l": "H(+) + o-quinone methide + penilactone D = penilactone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42096", "l": "ATP + carbamoyl phosphate + H2O + tobramycin = AMP + diphosphate + H(+) + nebramycin 5' + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21315", "l": "2,5-dihydroxybenzoate + H(+) <=> CO2 + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15269", "l": "L-xylo-hex-3-ulonolactone = H(+) + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33980", "l": "DIBOA beta-D-glucoside + H2O => D-glucose + DIBOA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13754", "l": "2 L-glutamate + NAD(+) => 2-oxoglutarate + H(+) + L-glutamine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58695", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV <=> FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44887", "l": "a cardiolipin + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69402", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP] => a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50944", "l": "3-phenylpropanoate + NAD(+) = (E)-cinnamate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61863", "l": "dehydroprobetaenone I + H(+) + NADPH + O2 <=> epoxybetaenone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103047", "l": "methyl beta-D-glucoside 6-phosphate glucohydrolase activity", "d": ["Catalysis of the reaction: methyl beta-D-glucoside 6-phosphate + H2O = beta-D-glucose 6-phosphate + methanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0042288", "l": "MHC class I protein binding", "d": ["Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34235", "l": "4-nitro-6-oxohepta-2,4-dienedioate = 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68157", "l": "(2E)-geranyl diphosphate + L-glutamate => diphosphate + N-geranyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58849", "l": "(6E)-8-hydroxygeraniol + NAD(+) => (6E)-8-hydroxygeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168046", "l": "Collagen type XII degradation by MMP12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388811", "l": "CD28 homodimer binds B7-1 homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961874", "l": "DHFR gene expression is stimulated by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66503", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6795460", "l": "SGK1 phosphorylates MDM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36190", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.843050782660015", "identifiers": [{"i": "GO:0004970", "l": "ionotropic glutamate receptor activity", "d": ["Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615910", "l": "SUMOylation of PCNA with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247497", "l": "ERBB3 binds neuregulins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60843", "l": "a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034921", "l": "cis-4,5-dihydroxy-4,5-dihydropyrene dehydrogenase activity", "d": ["Catalysis of the reaction: cis-4,5-dihydroxy-4,5-dihydropyrene = 4,5-dihydroxypyrene + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.146", "l": "\"beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65527", "l": "9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811412", "l": "Active ARF recruits coatomer to the Golgi (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0097004", "l": "adipokinetic hormone binding", "d": ["Binding to an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9669854", "l": "KIT binds type II TKIs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71300", "l": "chloride(out) + L-isoleucine(out) + 2 Na(+)(out) => chloride(in) + L-isoleucine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13793", "l": "2-methyleneglutarate = 2-methylene-3-methylsuccinate", "d": []}, {"i": "EC:5.4.99.4", "l": "\"2-methyleneglutarate mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58892", "l": "3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9 = adenosine 3',5'-bisphosphate + H(+) + omega-sulfo-beta-dihydromenaquinone-9", "d": []}, {"i": "EC:2.8.2.40", "l": "\"omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954182", "l": "ERBB4s80:TAB2:NCOR1 complex binds S100B gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904288", "l": "BAT3 complex binding", "d": ["Binding to a BAT3 complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58066", "l": "5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0106260", "l": "DNA-DNA tethering activity", "d": ["Bridging together two regions of a DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59550", "l": "H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone => N,N',N''-triacetylchitotriose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606312", "l": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186785", "l": "PDGF-AA clevage by Furin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30149", "l": "FAD + 2 H(+) + NADH => FADH2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.535054500181104", "identifiers": [{"i": "GO:0030414", "l": "peptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43640", "l": "dodecanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + CoA", "d": []}, {"i": "EC:2.3.1.301", "l": "\"mycobacterial beta-ketoacyl-[acyl carrier protein] synthase III\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17221", "l": "dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O", "d": []}, {"i": "EC:4.2.1.46", "l": "\"dTDP-glucose 4,6-dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26137", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111264", "l": "Addition of nucleotides between position +11 and +30 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29616", "l": "alpha-maltotriose + beta-maltose => alpha-maltotetraose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53844", "l": "glycochenodeoxycholate + NAD(+) = 7-oxoglycolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24107", "l": "7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA <=> 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8934742", "l": "RUNX1 binds PRMT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48929", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19654", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) => CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018465", "l": "vanillyl-alcohol oxidase activity", "d": ["Catalysis of the reaction: O2 + vanillyl alcohol = H2O2 + vanillin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65686", "l": "a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654399", "l": "Activated FGFR2 binds FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17346", "l": "(S)-methylmalonyl-CoA + H2O => CoA + H(+) + methylmalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432544", "l": "Phosphorylated PER transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74731", "l": "rhamnetin + S-adenosyl-L-methionine = 7,4'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877187", "l": "P2X7 mediates loss of intracellular K+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167235", "l": "Formation of the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19371", "l": "H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine => L-histidyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10254", "l": "L-cysteine + phosphate => H(+) + hydrogen sulfide + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59759", "l": "L-arginine + S-adenosyl-L-methionine <=> H(+) + N(omega)-methyl-L-arginine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106211", "l": "inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: 5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H+ + phosphate."]}, {"i": "RHEA:59500", "l": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434004", "l": "viral dsRNA binds the toll-like receptor 3 (TLR3) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507719", "l": "p62:MEKK3 binds to TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40270", "l": "(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) <=> 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57428", "l": "anisole + O2 + reduced [NADH--hemoprotein reductase] = formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033937", "l": "3-deoxy-2-octulosonidase activity", "d": ["Catalysis of the endohydrolysis of the beta-ketopyranosidic linkages of 3-deoxy-D-manno-2-octulosonate in capsular polysaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71991", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = (-)-astellatene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28674", "l": "2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761186", "l": "Expression of OSR1 in intermediate mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299318", "l": "Activation of TASK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9032798", "l": "DOCK3 activates RAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56551", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.16", "l": "\"4-hydroxy-2-oxoglutarate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41012", "l": "(+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114544", "l": "p115-RhoGEF activation of RHOA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72493", "l": "citrate(in) + maleate(out) => citrate(out) + maleate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8943279", "l": "GGT dimers hydrolyse GSH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57662", "l": "(+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396007", "l": "IRF3 is phosphorylated by TBK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0005237", "l": "inhibitory extracellular ligand-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40802", "l": "2-methylpropanoyl-CoA + H2O <=> 2-methylpropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60439", "l": "3-methylbutyl acetate + H2O <=> 3-methylbutanol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102421", "l": "curcumin-4'-O-beta-D-gentiobioside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: curcumin 4'-O-beta-D-gentiobioside + UDP-alpha-D-glucose <=> curcumin 4'-O-beta-D-gentiotrioside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34728", "l": "H2O + N-acyl-15-methylhexadecasphinganine => 15-methylhexadecasphinganine + a carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12914", "l": "(R)-lipoate + ATP + H(+) => (R)-lipoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47752", "l": "5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine = 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139941", "l": "Binding of IP3 to IP3 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44736", "l": "acetyl-CoA + dihydroxyacetone phosphate = 3-hydroxy-2,4-dioxopentyl phosphate + CoA", "d": []}, {"i": "EC:2.3.1.245", "l": "\"3-hydroxy-5-phosphooxypentane-2,4-dione thiolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13822", "l": "2-oxoglutarate + glutarate + O2 => (S)-2-hydroxyglutarate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0033840", "l": "NDP-glucose-starch glucosyltransferase activity", "d": ["Catalysis of the reaction: NDP-glucose + (1,4-alpha-D-glucosyl)n = NDP + (1,4-alpha-D-glucosyl)n+1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0017018", "l": "myosin phosphatase activity", "d": ["Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55401", "l": "7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) => archaeosine(15) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655839", "l": "Expression of Phosphomevalonate Kinase (PMVK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62337", "l": "AMP + ATP => adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29601", "l": "H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase] => monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191402", "l": "Reduction of presqualene diphosphate to form squalene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16591", "l": "3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2 => A + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362386", "l": "Glycosylation of Hh (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448963", "l": "Interaction of MyoD:E protein with MEF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28162", "l": "cytidine + GTP = CMP + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70082", "l": "2-oxoglutarate + clavatol + O2 <=> CO2 + hydroxyclavatol + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71549", "l": "5-N(alpha)-glycyl-dTMP in DNA + phosphate => 5-phosphomethyl-dUMP in DNA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24463", "l": "H(+) + malonyl-[ACP] <=> acetyl-[ACP] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72659", "l": "NADPH + O2 + quinolin-8-ol = 8-hydroxyquinoline N-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47961", "l": "H2O + N(tele)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33120", "l": "(2E,6E)-farnesyl diphosphate => (+)-sativene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28310", "l": "beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.252", "l": "\"GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21475", "l": "ATP + citrate + CoA <=> (3S)-citryl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666008", "l": "SCAI binds SRF:MKL1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015209", "l": "cytosine transmembrane transporter activity", "d": ["Enables the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35346", "l": "3-hydroxydocosanoyl-CoA + NADP(+) <=> 3-oxodocosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21113", "l": "globoside Gb3Cer (d18:1(4E)) + H2O => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28178", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate = colnelenate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49926", "l": "(R)-carnitine(in) + O-acyl-(R)-carnitine(out) => (R)-carnitine(out) + O-acyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73532", "l": "CTP(out) + UTP(in) => CTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13639", "l": "H2O + methanol + NAD(+) => H(+) + methane + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55500", "l": "ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35435", "l": "cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose = cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP", "d": []}, {"i": "EC:2.4.2.50", "l": "\"cyanidin 3-O-galactoside 2''-O-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25478", "l": "alpha-himachalene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17223", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O => dTDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39348", "l": "(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH => (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0001091", "l": "RNA polymerase II general transcription initiation factor binding", "d": ["Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428609", "l": "Type I Na+-coupled phosphate co-transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29968", "l": "2'-deoxyuridine(in) + H(+)(in) => 2'-deoxyuridine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74128", "l": "peonidin + UDP-alpha-D-galactose => peonidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23045", "l": "H(+) + N,N-dihydroxy-L-tyrosine => (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446372", "l": "Association of  PARVA with TESK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27397", "l": "4'-demethylrebeccamycin + H2O = beta-D-glucose + dichloroarcyriaflavin A", "d": []}, {"i": "EC:4.3.3.5", "l": "\"4'-demethylrebeccamycin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72934", "l": "O2 + proatranorin IV + reduced [NADPH--hemoprotein reductase] <=> atranorin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53482", "l": "5alpha-androstane-3beta,17beta-diol + NADP(+) => 3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382056", "l": "Crk binds to the active PDGF receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880053", "l": "2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35911", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.221", "l": "\"peptide-O-fucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37271", "l": "ATP + H2O + L-alanyl-L-glutamine(out) = ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49518", "l": "an adenosine in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(1)-methyladenosine in mRNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38024", "l": "gamma-tocotrienol => 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12476", "l": "H2O + N-formyl-L-glutamate = formate + L-glutamate", "d": []}, {"i": "EC:3.5.1.68", "l": "\"N-formylglutamate deformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34029", "l": "(E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH => 3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917696", "l": "Cargo Sequestration (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851011", "l": "TRIM27 polyubiquitinates PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54656", "l": "linalool = (2E)-geraniol", "d": []}, {"i": "EC:5.4.4.8", "l": "\"linalool isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853745", "l": "RET binds GFRA1,GFRA3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64221", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016738", "l": "oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen."]}, {"i": "EC:1.19.6.-", "l": "\"With dinitrogen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783670", "l": "CRLF1 binds CLCF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20373", "l": "ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA", "d": []}, {"i": "EC:6.2.1.17", "l": "\"propionate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2995330", "l": "COX10 transforms heme to heme O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24194", "l": "(2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+) => (2R,4S)-2,4-diaminopentanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44477", "l": "1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acetyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70286", "l": "H2O + N-acetylputrescine + O2 <=> 4-acetamidobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75442", "l": "eburicol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 14-demethyleburicol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2974737", "l": "NOTCH2 binds MDK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49172", "l": "8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004494", "l": "methylmalonyl-CoA mutase activity", "d": ["Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43432", "l": "butan-1-ol + 2 Fe(III)-[cytochrome c] = butanal + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}, {"i": "EC:1.1.2.9", "l": "\"1-butanol dehydrogenase (cytochrome c)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49787", "l": "chenodeoxycholoyl-CoA + taurine <=> CoA + H(+) + taurochenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858489", "l": "ppDVL binds DAAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352059", "l": "SLC6A15-mediated amino acid uptake (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24878", "l": "A + L-sorbopyranose = 1-dehydro-L-sorbose + AH2", "d": []}, {"i": "EC:1.1.99.32", "l": "\"L-sorbose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59174", "l": "AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] => hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74403", "l": "2 (S)-lactate(in) + prostaglandin D2(out) = 2 (S)-lactate(out) + prostaglandin D2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43339", "l": "H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) <=> CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43521", "l": "2-carboxy-5-(dihydroxymethyl)furan + O2 => 2,5-dicarboxyfuran + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0016898", "l": "oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule."]}, {"i": "EC:1.1.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052839", "l": "inositol diphosphate tetrakisphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + inositol diphosphate tetrakisphosphate = ADP + inositol bisdiphosphate trisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353460", "l": "REV1-Pol kappa complex formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392834", "l": "Activation of EPACs by cAMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61703", "l": "glycyl-5'-AMP + holo-[peptidyl-carrier protein] <=> AMP + glycyl-[peptidyl-carrier protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48711", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol <=> a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170986", "l": "Ral-GDS binds to Ras-GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159796", "l": "Furin cleaves pro-factor IX to factor IX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30401", "l": "alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9676268", "l": "Formation of the MLL4 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58907", "l": "8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH <=> C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052846", "l": "inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity", "d": ["Catalysis of the reaction: 1,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16479", "l": "15-oxoprostaglandin E1 + H(+) + NADH => NAD(+) + prostaglandin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110319", "l": "Elongation by POLH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23263", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+) <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106405", "l": "isoprenoid diphosphate phosphatase activity", "d": ["Catalysis of the dephosphorylation of isoprenoid diphosphates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58205", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine => dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189069", "l": "sucrose + H2O => glucose + fructose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20931", "l": "[DsbA protein]-dithiol + a quinone <=> [DsbA protein]-disulfide + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75987", "l": "a dicarboxylate(in) + indoxyl sulfate(out) = a dicarboxylate(out) + indoxyl sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671772", "l": "p-T38-PPP1R14A binds MLCP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607751", "l": "TRAF6 oligomerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20637", "l": "D-fructose + D-glucose = D-glucono-1,5-lactone + D-sorbitol", "d": []}, {"i": "EC:1.1.99.28", "l": "\"glucose-fructose oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21535", "l": "ATP + glutathione + glutathionylspermidine <=> ADP + H(+) + phosphate + trypanothione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62276", "l": "3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine = 6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865605", "l": "BRWD1 binds SMARCA4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44434", "l": "a 1,2-diacylglycerol + glycerol => 2 a 1-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63579", "l": "ecdysone 22-phosphate + H2O <=> ecdysone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70255", "l": "1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59824", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate = L-glutamate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34415", "l": "(1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130504", "l": "Cleavage of lip22 to lip10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110218", "l": "Cleavage of uracil by TDG glycosylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5159250", "l": "ATF7IP binds SETDB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047823", "l": "D-glutamyltransferase activity", "d": ["Catalysis of the reaction:  D-glutamate + D-glutamine = gamma-D-glutamyl-D-glutamate + NH4+. Can also transfer additional glutamyl residues to a peptide, extending the polypeptide chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35159", "l": "(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O = (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1170539", "l": "Prolactin receptor is internalized (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-167415", "l": "G-protein alpha subunit is inactivated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60021", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + sesquisabinene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26304", "l": "5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) <=> (S)-allantoin + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56836", "l": "[PQQ precursor protein] + S-adenosyl-L-methionine = 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine", "d": []}, {"i": "EC:1.21.98.4", "l": "\"PqqA peptide cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12671", "l": "L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate => H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42895", "l": "5'-deoxyadenosine + H(+) + H2O <=> 5'-deoxyinosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47110", "l": "H2O + taurocholate => cholate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2471842", "l": "Collagen type XXV ectomain shedding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73481", "l": "D-histidine(out) + H(+)(out) + L-ornithine(in) => D-histidine(in) + H(+)(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16877", "l": "3-sulfino-L-alanine + H(+) = CO2 + hypotaurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66829", "l": "2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64164", "l": "2-methyl-L-serine = formaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60368", "l": "urate(out) = urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37452", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA => 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41641", "l": "3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA => 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112690", "l": "PTPN11 binds CBL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18146", "l": "ATP + beta-D-fructose => ADP + beta-D-fructose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10454", "l": "(R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase] => 2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682020", "l": "MRN complex binds shortened telomeres (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420977", "l": "Ca permeable AMPA receptor ligand binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008192", "l": "RNA guanylyltransferase activity", "d": ["Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56418", "l": "alpha-D-glucose 1-phosphate + glycerol => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5220959", "l": "TDG excises 5-formylcytosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.349248930891576", "identifiers": [{"i": "GO:0009975", "l": "cyclase activity", "d": ["Catalysis of a ring closure reaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34196", "l": "2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 => 2 aureusidin 6-O-beta-glucoside + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.17", "l": "\"stromelysin 1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19353", "l": "glycocholate + H2O = cholate + glycine", "d": []}, {"i": "EC:3.5.1.24", "l": "\"choloylglycine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29096", "l": "5 H(+)(in) + NADH + ubiquinone-8 => 4 H(+)(out) + NAD(+) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58056", "l": "hypotaurine + pyruvate = 2-sulfinoacetaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.9", "l": "\"nucleotide diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32148", "l": "H2O + sepiapterin => 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617833", "l": "SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.36", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29395", "l": "H2O + UTP = diphosphate + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59593", "l": "ATP + beta-alanine + L-arginine => ADP + beta-alanyl-L-arginine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58101", "l": "1-(15Z-tetracosenoyl)-glycerol + H2O => (15Z)-tetracosenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41244", "l": "N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine => N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473184", "l": "Follistatin (FST) binds Activin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0019786", "l": "protein-phosphatidylethanolamide deconjugating activity", "d": ["Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001854", "l": "complement component C3d binding", "d": ["Binding to a C3d product of the complement cascade."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34576", "l": "2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70901", "l": "(2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32462", "l": "2 S-adenosyl-L-methionine + uroporphyrinogen III <=> H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419049", "l": "ROCK activation by RHO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24477", "l": "H2O + maleimide => H(+) + maleamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35924", "l": "neamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin B + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58637", "l": "N-(9Z-octadecenoyl)-(2S)-hydroxyglycine => (9Z)-octadecenamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45580", "l": "D-galactaro-1,5-lactone = D-galactaro-1,4-lactone", "d": []}, {"i": "EC:5.4.1.4", "l": "\"D-galactarolactone isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39845", "l": "a triacyl-sn-glycerol + CoA => 1,3-diacyl-sn-glycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1183058", "l": "Expression of Adiponectin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23471", "l": "2-aminobenzenesulfonate + 2 H(+) + NADH + O2 <=> 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102707", "l": "S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity", "d": ["Catalysis of the reaction: beta-alanine + S-adenosyl-L-methionine = H+ + N-methyl-beta-alanine + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050054", "l": "lignostilbene alpha beta-dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 = 2 vanillin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67508", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-sn-glycero-3-phosphocholine = 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28815", "l": "4-hydroxybenzoate(in) + H(+)(out) = 4-hydroxybenzoate(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534096", "l": "METAP1/2 demethylates GNAT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3858489", "l": "ppDVL binds DAAM1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34707", "l": "AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane", "d": []}, {"i": "EC:4.7.1.1", "l": "\"alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14159", "l": "diphosphate + phosphate => H2O + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24082", "l": "AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp) => ATP + L-tryptophan + tRNA(Trp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34514", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29520", "l": "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0048763", "l": "calcium-induced calcium release activity", "d": ["Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.69", "l": "\"5-hydroxyfuranocoumarin 5-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873921", "l": "Binding of STAT1 to p-IFNGR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2169046", "l": "Degradation of TGF-beta receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75533", "l": "A + H2O + N-acetyl-L-cysteine => AH2 + N-acetyl-S-hydroxy-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61938", "l": "ADP + cycloheximide(out) + H(+) + phosphate => ATP + cycloheximide(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52388", "l": "ATP + D-threonate = 4-O-phospho-D-threonate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.219", "l": "\"D-threonate 4-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11643", "l": "a (2R,3R)-flavan-3-ol + 2 NAD(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786118", "l": "IL13 binds IL13RA:TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62606", "l": "7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36069", "l": "Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine => Co-precorrin-6B + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55473", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626681", "l": "Recruitment of transition zone proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29475", "l": "(2E,6E)-farnesyl diphosphate = (+)-cubenene + diphosphate", "d": []}, {"i": "EC:4.2.3.63", "l": "\"(+)-cubenene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404144", "l": "Parenchymal atROL translocates to HSCs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607746", "l": "PKC-delta is activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51879", "l": "2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate <=> desmethylxanthohumol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396392", "l": "NOTCH1 PEST domain mutants bind HES1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43505", "l": "5-hydroxymethylfurfural + O2 => 2,5-diformylfuran + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43981", "l": "H(+) + hexadecanoate + NADPH + O2 => 15-hydroxyhexadecanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110244", "l": "Excision of FapyG by OGG1 glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748991", "l": "XDH oxidises 6MP to 6TU (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032770", "l": "Translocation of YAP1 to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29776", "l": "alpha-D-ribose 1-phosphate + ATP => ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9725206", "l": "IgE binds FCERI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75964", "l": "15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione => 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45042", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + nitroxyl => 2 Fe(III)-[cytochrome c] + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001058", "l": "RNA polymerase V activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55946", "l": "chloroacetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+) => 2-chloroethanol + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17044", "l": "adenosine 5'-phosphosulfate + H2O <=> AMP + 2 H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203130", "l": "OLR1 binds to oxidized LDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11182", "l": "AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn) => ATP + L-asparagine + tRNA(Asn)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45337", "l": "(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine => [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111966", "l": "GRK2 binds CALM1:4Ca2+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25233", "l": "N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate", "d": []}, {"i": "EC:5.1.3.24", "l": "\"N-acetylneuraminate epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74909", "l": "(2E)-butenoyl-[ACP] + AMP + H(+) => (2E)-but-2-enoyl-AMP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234179", "l": "Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050572", "l": "L-idonate 5-dehydrogenase activity", "d": ["Catalysis of the reaction: L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51756", "l": "a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4,6-diprenylphloroglucinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981610", "l": "Neuroglobin binds oxygen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40539", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16340", "l": "a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3076905", "l": "Extracellular BTD hydrolyses BCTN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22261", "l": "H2O + triacetate lactone => H(+) + triacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52254", "l": "2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine => a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11059", "l": "4-aminobenzoate + 2 H(+) + NADPH + O2 <=> 4-aminophenol + CO2 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196417", "l": "Reduction of desmosterol to cholesterol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73459", "l": "5 H(+) + 2 O2 + protochlorophyllide a + 4 reduced [2Fe-2S]-[ferredoxin] = 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47628", "l": "glyoxylate + H2O + propanoyl-CoA = 3-methylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71280", "l": "chloride(out) + L-leucine(out) + 2 Na(+)(out) => chloride(in) + L-leucine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73486", "l": "D-lysine(in) + L-ornithine(out) <=> D-lysine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29264", "l": "L-leucine(in) + Na(+)(in) => L-leucine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54463", "l": "1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793921", "l": "Expression of DLL1 in paraxial mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58692", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV = FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68076", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.362525179576039", "identifiers": [{"i": "GO:0016646", "l": "oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP."]}, {"i": "EC:1.5.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868071", "l": "Clathrin recruits PIK3C2A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44664", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803063", "l": "RNASEs bind bacterial LPS, PGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50739", "l": "a quinone + 2 H(+) + hydrogen sulfide + sulfite <=> a quinol + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39296", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54844", "l": "H(+) + hexan-3-one + NADPH + O2 = ethyl butanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9667456", "l": "AVPR1A,B bind desmopressin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54918", "l": "9-cis-retinal + H(+) + NADPH => 9-cis-retinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46281", "l": "an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63577", "l": "ecdysone 22-phosphate + H2O => ecdysone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22134", "l": "ADP + D-maltose(in) + H(+) + phosphate => ATP + D-maltose(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17050", "l": "3-demethylubiquinol-9 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674808", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8979071", "l": "KDM6B binds iron (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12105", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP => 7,8-dihydrofolate + dTMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879909", "l": "Activation of STAT5a/b by JAK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791016", "l": "SFTPB binds itself (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57147", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.9", "l": "\"spheroidene monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390438", "l": "FAR2 reduces PalmCoA to HXOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004380", "l": "glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68710", "l": "diphosphate + linalool => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46027", "l": "H2O2 + tetradecanoate <=> (3R)-hydroxytetradecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20127", "l": "NADPH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45120", "l": "(4R)-ipsdienol + NAD(+) = H(+) + ipsdienone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.296", "l": "\"dihydrocarveol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30780", "l": "D-gluconate + FAD + H(+) => 2-dehydro-D-gluconate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40222", "l": "H2O + malonyl-CoA <=> CoA + H(+) + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867344", "l": "OMA1 hydrolyses OPA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.10.1", "l": "\"receptor protein-tyrosine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848758", "l": "PTK6 phosphorylates AKT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9652264", "l": "ERBB2 binds TKIs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66123", "l": "2-oxobutanoate + L-methionine <=> (2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15642", "l": "H(+) + oxaloacetate => CO2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357483", "l": "RAC1 binds PAK1-3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69019", "l": "3alpha-hydroxy-5beta-pregnan-20-one + NADP(+) <=> 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601910", "l": "Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54768", "l": "[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine = [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48507", "l": "D-glycero-D-manno-heptose 1,7-bisphosphate + H2O <=> D-glycero-D-manno-heptose 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57871", "l": "(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 <=> (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5688786", "l": "ATXN3 binds RAD23 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388808", "l": "CD28 homodimer binds B7-2 monomer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759364", "l": "AcK-NFE2L2-dependent TXNRD1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74929", "l": "(2E)-butenoyl-[ACP] + glycine + H2O => (3R)-3-[(carboxymethyl)amino]butanoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51340", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8850945", "l": "Casein kinase II phosphorylates PTEN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.237", "l": "\"hydroxyphenylpyruvate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72621", "l": "Ribosomal scanning  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23203", "l": "H2O + N(6)-methyl-L-lysine + O2 <=> formaldehyde + H2O2 + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019116", "l": "hydroxy-nicotine oxidase activity", "d": ["Catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008145", "l": "phenylalkylamine binding", "d": ["Binding to phenylalkylamine or one of its derivatives."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32943", "l": "a 1,2-diacyl-sn-glycerol + CDP-ethanolamine = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418904", "l": "A1 and A3 receptors bind adenosine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635102", "l": "GPR161 is internalized (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14830", "l": "hydrogen sulfide + O-acetyl-L-serine => acetate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15617", "l": "Fe(3+) + Fe(II)-[cytochrome c] = Fe(2+) + Fe(III)-[cytochrome c]", "d": []}, {"i": "EC:1.9.98.1", "l": "\"iron--cytochrome-c reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625196", "l": "Unfolded substrate in LAMP2a multimeric complex binds HSPA8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56709", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21370", "l": "5-hydroxyisourate + H2O2 => H2O + O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30516", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + S-methyl-5'-thioadenosine + thermospermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42715", "l": "S-adenosyl-L-methionine + uridine(54) in tRNA <=> 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49908", "l": "(R)-carnitine(out) + O-acetyl-(R)-carnitine(in) = (R)-carnitine(in) + O-acetyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759751", "l": "SNAI1 binds the CLDN7 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-481009", "l": "Exocytosis of platelet dense granule content (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67029", "l": "(glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O => (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004821", "l": "histidine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847537", "l": "RAB43:GTP binds USP8NL (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050258", "l": "riboflavinase activity", "d": ["Catalysis of the reaction: H2O + H+ + riboflavin = D-ribitol + lumichrome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45063", "l": "H2O + N-(9Z-octadecenoyl) ethanolamine <=> (9Z)-octadecenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805792", "l": "p-S291-PHF20 translocates to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997237", "l": "SH2B proteins bind JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11441", "l": "2,3,5,6-tetrachlorophenol + NADPH + O2 => 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.140", "l": "\"alternansucrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38897", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58992", "l": "(E)-cinnamaldehyde + H2O + O2 = (E)-cinnamate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10154", "l": "ADP + carbamoyl phosphate + H(+) + H2O => ATP + hydrogencarbonate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27351", "l": "arseno-mycothiol + H2O => arsenate + mycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.3.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13064", "l": "O2 + S-sulfanylglutathione <=> glutathione S,S-dioxide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38473", "l": "3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine => L-histidine + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51999", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905059", "l": "P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "d": ["A calcium-transporting P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687377", "l": "Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34667", "l": "C30 botryococcene + S-adenosyl-L-methionine = 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-481009", "l": "Exocytosis of platelet dense granule content (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0046994", "l": "oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound."]}, {"i": "EC:1.12.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216043", "l": "Collagen type II binds integrin alpha10beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40441", "l": "6-deoxy-6-sulfo-D-fructose => 6-sulfo-beta-D-quinovose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71899", "l": "3',5'-cyclic GMP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52819", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26197", "l": "H2O + melamine = ammeline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48577", "l": "4-chlorocatechol + O2 => 3-chloro-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917700", "l": "MVB Vesicle Formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199154", "l": "CD200 binds to CD200R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070457", "l": "D-galactose-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: D-galactose-1-phosphate + H2O = D-galactose + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10541", "l": "7,8-dihydroneopterin => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74040", "l": "D-alanine(out) + L-alanine(in) => D-alanine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043717", "l": "2-hydroxyglutaryl-CoA dehydratase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxyglutaryl-CoA = H2O + glutaconyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004534", "l": "5'-3' RNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13018", "l": "diphosphate + UMP => 5-phospho-alpha-D-ribose 1-diphosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018815", "l": "3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity", "d": ["Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = 2-oxobut-3-enanoate + 2,5,6-trihydroxy-3-methylpyridine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614614", "l": "Cysteine is degraded to serine and H2S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9609310", "l": "β-blockers bind ADRB1,2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629499", "l": "NEIL3 cleaves thymine glycol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022893", "l": "low-affinity tryptophan transmembrane transporter activity", "d": ["Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811479", "l": "ING2 recruits EP300 to TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74575", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] = N(alpha)-acetyl-L-methionine + N-terminal L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67682", "l": "a long-chain fatty acid + CoA + H(+) => a long-chain fatty acyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46957", "l": "hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75826", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] <=> 5-oxo-(6E,8Z)-octadecadienoate + H(+) + 2 H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48499", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62470", "l": "3,4-dihydroxybenzoyl-5'-AMP + diphosphate => 3,4-dihydroxybenzoate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50130", "l": "17-oxoresolvin D1 + H(+) + NADH => NAD(+) + resolvin D1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106422", "l": "carotenoid isomerooxygenase activity", "d": ["Catalysis of the reaction: Zeaxanthin + O2 <=> (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047962", "l": "glycine N-benzoyltransferase activity", "d": ["Catalysis of the reaction: benzoyl-CoA + glycine = N-benzoylglycine + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34933", "l": "glutathione + hydrogenselenide + NADP(+) => glutathioselenol + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68640", "l": "(2E)-geranyl diphosphate = diphosphate + limonene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22008", "l": "L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine", "d": []}, {"i": "EC:2.3.1.46", "l": "\"homoserine O-succinyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482772", "l": "Release of platelet cytosolic components (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42346", "l": "(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) => H(+) + NADH + O2 + p-cumate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061608", "l": "nuclear import signal receptor activity", "d": ["Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805205", "l": "GPR35 binds kynurenic acid (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9639286", "l": "RRAGC,D exchanges GTP for GDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626549", "l": "IQGAPs bind CALM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6805811", "l": "Release of SEPT4 from mitochondria (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849908", "l": "SALM4 binds flotillin-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57393", "l": "(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine => 3-O-acetyl-4'-O-demethylpapaveroxine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46436", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24839", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043834", "l": "trimethylamine methyltransferase activity", "d": ["Catalysis of the reaction: trimethylamine + a trimethylamine corrinoid protein = a methylated trimethylamine corrinoid protein + dimethylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173542", "l": "SMURF2 ubiquitinates SMAD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48889", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione => (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030369", "l": "ICAM-3 receptor activity", "d": ["Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603419", "l": "Activated NTRK3 binds SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694605", "l": "nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69835", "l": "campesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22S)-22-hydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29950", "l": "H(+)(in) + L-rhamnopyranose(in) <=> H(+)(out) + L-rhamnopyranose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58138", "l": "acetyl-AMP + diphosphate => acetate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685838", "l": "CX3 complex binds D-loop structures (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73589", "l": "CTP(in) + UMP(out) => CTP(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202307", "l": "Change of PKC theta conformation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038036", "l": "sphingosine-1-phosphate receptor activity", "d": ["Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29272", "l": "a menaquinol + H(+) + trimethylamine N-oxide => a menaquinone + H2O + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.7.4", "l": "\"4-hydroxy-3-methylbut-2-enyl diphosphate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008936", "l": "nicotinamidase activity", "d": ["Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2002428", "l": "Removal of fibrillar collagen N-propeptides (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53507", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61172", "l": "myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47480", "l": "deoxycholate + NADP(+) = 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674531", "l": "AAMP binds EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994020", "l": "IRF1 binds the promoters of Interferon alpha and beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635927", "l": "ATF4 and a CEBP protein bind the TRIB3 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51298", "l": "a quinol + L-methionyl-(R)-S-oxide-[protein] => a quinone + H2O + L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668831", "l": "CST complex formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027562", "l": "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74253", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+) => 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21567", "l": "acetyl-CoA + an acyl-CoA <=> a 3-oxoacyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67719", "l": "NADPH + 2 oxidized [2Fe-2S]-[protein] <=> H(+) + NADP(+) + 2 reduced [2Fe-2S]-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022065", "l": "DSPGs are secreted (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.202", "l": "\"2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24096", "l": "isoorientin + S-adenosyl-L-methionine = H(+) + isoscoparin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.78", "l": "\"isoorientin 3'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18793", "l": "alpha-D-ribose 1-phosphate = D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24103", "l": "diisopropyl fluorophosphate + H2O <=> diisopropyl phosphate + fluoride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11620", "l": "H2O + L-2-amino-4-chloropent-4-enoate = 2-oxopent-4-enoate + chloride + H(+) + NH4(+)", "d": []}, {"i": "EC:4.5.1.4", "l": "\"L-2-amino-4-chloropent-4-enoate dehydrochlorinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55206", "l": "5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+) => 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9656244", "l": "DRD2 binds DA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015350", "l": "methotrexate transmembrane transporter activity", "d": ["Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.13", "l": "\"ABC-type D-xylose/L-arabinose transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380177", "l": "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19071", "l": "glutathione + methylglyoxal => (R)-S-lactoylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51912", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12876", "l": "(R)-2-hydroxy-4-methylpentanoate + NADP(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30822", "l": "allantoin + H2O <=> allantoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16238", "l": "[protein]-peptidylproline (omega=180) => [protein]-peptidylproline (omega=0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796617", "l": "MIB2 binds CFLAR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018618", "l": "anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity", "d": ["Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216941", "l": "Phosphorylation of Chk1 by ATR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373745", "l": "SDK1 homophillic interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45377", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507719", "l": "p62:MEKK3 binds to TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604732", "l": "Autocatalytic activation of proMMP13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29202", "l": "(S)-dihydroorotate + menaquinone-8 <=> menaquinol-8 + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.153", "l": "\"sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42176", "l": "(9Z)-tetradecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-tetradecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6794346", "l": "NRXNs bind NLGNs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13286", "l": "ATP + L-cysteine + L-glutamate => ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667619", "l": "AVPR1A,B,2 bind atosiban (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33020", "l": "(3S)-3,6-diaminohexanoate + acetyl-CoA => (3S)-6-acetamido-3-aminohexanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56866", "l": "(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+) => 12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67098", "l": "CO2 + fumigatonoid A + succinate => 2-oxoglutarate + asnovolin A + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72672", "l": "The 60S subunit joins the translation initiation complex  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052836", "l": "inositol 5-diphosphate pentakisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: ATP + inositol 5-diphosphate pentakisphosphate = ADP + inositol 5-triphosphate pentakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640195", "l": "RRAGA,B hydrolyzes GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693536", "l": "ATM phosphorylates MDC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71650", "l": "a medium-chain (3S)-3-hydroxyacyl-CoA <=> a medium-chain (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42653", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine => diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16385", "l": "4-hydroxybenzoate + 2 H(+) + NADPH + O2 = CO2 + H2O + hydroquinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54333", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140473", "l": "telomere-nuclear envelope anchor activity", "d": ["The binding activity of a molecule that brings together the telomeric region of a chromosome and the inner nuclear membrane by interacting with both the telomere and the nuclear membrane, in order to establish and maintain the telomeric location."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449087", "l": "CD4 binds Interleukin-16 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770132", "l": "Formation of the Spliceosomal Pre-B complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28100", "l": "AMP + guanosine 3',5'-bis(diphosphate) => ATP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57604", "l": "a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43358", "l": "cholesteryl (9Z,12Z)-octadecadienoate(out) => cholesteryl (9Z,12Z)-octadecadienoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59923", "l": "(2E)-octenal + H2O + NAD(+) <=> (2E)-octenoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58118", "l": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP => L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48661", "l": "8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59193", "l": "ATP + eicosanoate + H(+) => diphosphate + icosanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25527", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> 9alpha-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71343", "l": "chloride(out) + L-histidine(out) + 2 Na(+)(out) = chloride(in) + L-histidine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047248", "l": "nuatigenin 3-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: nuatigenin + UDP-D-glucose = H+ + nuatigenin 3-beta-D-glucopyranoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140348", "l": "lysophosphatidylcholine flippase activity", "d": ["Catalysis of the movement of lysophosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714580", "l": "SLC6A3 binds DRIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65542", "l": "an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose => ganglioside GM3 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21924", "l": "3-dehydro-L-gulonate + NAD(+) = 2,3-dioxo-L-gulonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061786", "l": "peptidoglycan stem peptide endopeptidase activity", "d": ["A peptidoglycan endopeptidase activity that acts on a stem peptide of peptidoglycan."]}]}
{"type": "biolink:MolecularActivity", "ic": "44.314920163712856", "identifiers": [{"i": "GO:0022857", "l": "transmembrane transporter activity", "d": ["Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034866", "l": "2,4,4-trimethylpentanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethylpentanoyl-CoA = 2,4,4-trimethylpent-2-enoyl-CoA + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014433", "l": "RHOG GEFs activate RHOG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047705", "l": "bilirubin oxidase activity", "d": ["Catalysis of the reaction: 2 bilirubin + O2 = 2 biliverdin + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.3.1", "l": "\"NAD(P)H oxidase (H2O2-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35144", "l": "benzoyl-CoA + 2 H(+) + 3 malonyl-CoA => 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617179", "l": "PRKACA phosphorylates TNNI3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32251", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) = (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16653", "l": "D-gluconate + NADP(+) = 2-dehydro-D-gluconate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.215", "l": "\"gluconate 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50842", "l": "(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990135", "l": "flavonoid sulfotransferase activity", "d": ["Catalysis of the reaction: a flavonoid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated flavonoid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a flavonoid acceptor, producing the sulfated flavonoid derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390641", "l": "ADRA1A,B,D bind ADR,NAd (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51679", "l": "[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide <=> [protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875077", "l": "SLC27A3 ligates CoA-SH to VLCFA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68898", "l": "4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+) => 4-hydroxybenzoate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16307", "l": "3-hydroxy-3-methylglutarate + CoA + H(+) => (3S)-hydroxy-3-methylglutaryl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49984", "l": "H(+) + jasmonate + NADPH + O2 = (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.228", "l": "\"jasmomic acid 12-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70285", "l": "4-acetamidobutanal + H2O2 + NH4(+) => H2O + N-acetylputrescine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805470", "l": "AMPK phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27531", "l": "(2E,6E)-farnesyl diphosphate + H2O => (3S,6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19157", "l": "D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": []}, {"i": "EC:4.2.1.82", "l": "\"xylonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40130", "l": "an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14654", "l": "a nucleoside 3',5'-cyclic phosphate + H2O => a nucleoside 5'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41285", "l": "sphing-4-enine + tetracosanoate => H2O + N-tetracosanoyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67168", "l": "2-oxoglutarate + 3-hydroxy-L-phenylalanine = 3-(3-hydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050519", "l": "holo-citrate lyase synthase activity", "d": ["Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.61", "l": "\"mycodextranase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.2.-", "l": "\"Amidinotransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203613", "l": "depalmitoylation of eNOS (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41057", "l": "1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5627072", "l": "RHOQ binds GOPC:CFTR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44670", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+) => 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676257", "l": "Formation of the SET1A complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53405", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697051", "l": "RTC binds NRTIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689000", "l": "AADAC deacetylates PHEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047997", "l": "hydroxypyruvate decarboxylase activity", "d": ["Catalysis of the reaction: 3-hydroxypyruvate + H+ = CO2 + glycolaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814409", "l": "CK2 phosphorylates PDCL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67286", "l": "(1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione => (2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694409", "l": "Nucleotide exchange on RAB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50189", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209738", "l": "VD3 binds GC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109639", "l": "Formation of the closed pre-initiation complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50929", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901036", "l": "MAN1B1 hydrolyses a second 1,2-linked mannose (a branch) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70863", "l": "L-glutamine(out) + L-threonine(in) + Na(+)(out) = L-glutamine(in) + L-threonine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22610", "l": "(2S,6S)-2,6-diaminoheptanedioate + succinate => H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57762", "l": "C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168789", "l": "GHR internalization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36673", "l": "CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine => (17Z)-hexacosenoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30214", "l": "2 Fe(III)-[cytochrome c] + H2O + nitrous oxide <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65191", "l": "2-oxoglutarate + berkeleyone B + O2 <=> berkeleydione + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63081", "l": "AH2 + ATP + ilicicolinate B => A + AMP + diphosphate + ilicicolin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68811", "l": "6-O-alpha-D-glucopyranosyl-D-fructose + H2O <=> alpha-D-glucose + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43781", "l": "2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864431", "l": "TFAP2A,TFAP2C homodimers stimulate CGB3 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64620", "l": "(E)-sinapyl alcohol + acetyl-CoA = (E)-sinapoyl actetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56002", "l": "beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64171", "l": "2-ethyl-L-serine <=> (2S)-2-aminobutanoate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20976", "l": "a primary nitroalkane + H2O + O2 = an aldehyde + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65896", "l": "glyoxylate + L-kynurenine = glycine + H2O + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445714", "l": "Aquaporin-3 passively transports water out of cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47055", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28150", "l": "acetyl-CoA + spermidine = CoA + H(+) + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23956", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72048", "l": "A + D-alanine + D-allothreonine + D-leucine + 2 L-leucine + L-proline => AH2 + fusahexin + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64890", "l": "AMP + diphosphate + tetradecanoyl-[ACP] => ATP + holo-[ACP] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22890", "l": "succinyl-CoA => (R)-methylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46054", "l": "a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine => a 3'-end uridylyl-uridine-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13444", "l": "H2O + L-cysteate <=> H(+) + NH4(+) + pyruvate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43673", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31146", "l": "(3S)-hydroxyhexanoyl-CoA + NAD(+) <=> 3-oxohexanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34509", "l": "N,N-diacetyllegionaminate + phosphate => 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0042010", "l": "interleukin-15 receptor activity", "d": ["Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022894", "l": "Intermediate conductance calcium-activated potassium channel activity", "d": ["Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18395", "l": "2-methyl-3-oxopropanoate + L-alanine => (R)-3-amino-2-methylpropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19624", "l": "a nucleoside 2',3'-cyclic phosphate + H2O <=> a nucleoside 3'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16327", "l": "diphosphate + UDP-alpha-D-glucuronate => 1-phospho-alpha-D-glucuronate + H(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48060", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987120", "l": "JAK1 binds IFNLR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805638", "l": "KAT6A acetylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420977", "l": "Ca permeable AMPA receptor ligand binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22802", "l": "obtusifoliol => cycloeucalenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949580", "l": "F1Fo ATP synthase dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694462", "l": "ABHD6,12 hydrolyse 3AG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59697", "l": "D-cellotetraono-1,5-lactone + H2O => D-cellotetraonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218820", "l": "Src kinases phosphorylate VAV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102373", "l": "uvaol dehydrogenase activity", "d": ["Catalysis of the reaction: uvaol + NADPH + O2 + H+ <=> ursolic aldehyde + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38237", "l": "1-O-octadecyl (9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + octadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931981", "l": "RUNX1 binds ESR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418662", "l": "Src activation following P2Y purinoceptor activation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791122", "l": "Expression of PDIA5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030339", "l": "fatty-acyl-ethyl-ester synthase activity", "d": ["Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419428", "l": "S1PR2-5 bind S1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874138", "l": "ATF6B (ATF6-beta) translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45910", "l": "chloroeremomycin + dTDP + H(+) => chloroorienticin B + dTDP-beta-L-vancosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033816", "l": "diaminobutyrate acetyltransferase activity", "d": ["Catalysis of the reaction: L-2,4-diaminobutyrate + acetyl-CoA = N(4)-acetyl-L-2,4-diaminobutyrate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683801", "l": "CHEK2 phosphorylates BRCA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437084", "l": "ZnT3 transports zinc into synaptic vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134953", "l": "DHX36 or DHX9 binds MyD88 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.6", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031746", "l": "type 1 cysteinyl leukotriene receptor binding", "d": ["Binding to a type 1 cysteinyl leukotriene receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.34", "l": "\"cathepsin E\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37369", "l": "2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+) => CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58318", "l": "cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604969", "l": "Active FLT3 binds PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44224", "l": "16-hydroxyhexadecanoate + ATP + CoA = 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64294", "l": "(3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+) => 3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102965", "l": "alcohol-forming long-chain fatty acyl-CoA reductase activity", "d": ["Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid (LCFA) is a fatty acid with an aliphatic tail of 13 to 21 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59825", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate => L-glutamate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22140", "l": "a nucleoside 5'-phosphate + H2O = a nucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45934", "l": "4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA => 2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000319", "l": "BORA binds PLK1 and AURKA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38998", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29940", "l": "H(+)(in) + phosphate(in) => H(+)(out) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35219", "l": "8-oxo-dADP + H2O = 8-oxo-dAMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641111", "l": "Parkin transfers Ub to misfolded proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58572", "l": "O-acetyl-15alpha-stemmadenine + O2 = H2O2 + precondylocarpine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008968", "l": "D-sedoheptulose 7-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65996", "l": "Co(I)-[glycine betaine-specific corrinoid protein] + glycine betaine + H(+) = methyl-Co(III)-[glycine betaine-specific corrinoid protein] + N,N-dimethylglycine", "d": []}, {"i": "EC:2.1.1.376", "l": "\"glycine betaine--corrinoid protein Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54569", "l": "a uridine in rRNA => a pseudouridine in rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51041", "l": "indole-3-pyruvate imine dimer => chromopyrrolate + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445699", "l": "ATP Hydrolysis By Myosin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016501", "l": "prostacyclin receptor activity", "d": ["Combining with prostacyclin (PGI(2)) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52396", "l": "4-O-phospho-D-threonate + NAD(+) = CO2 + dihydroxyacetone phosphate + NADH", "d": []}, {"i": "EC:1.1.1.408", "l": "\"4-phospho-D-threonate 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75935", "l": "ATP + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine = 6-O-phospho-N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9692867", "l": "HRH3 binds pitosilant (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202127", "l": "eNOS synthesizes NO (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655142", "l": "RCHY1 binds POLH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001605", "l": "adrenomedullin receptor activity", "d": ["Combining with adrenomedullin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676133", "l": "CD74 binds MIF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-990489", "l": "Kinesin-13 is a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34577", "l": "2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone => 2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5444523", "l": "Formation of MSH1:PMS2 Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61499", "l": "an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose <=> an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327733", "l": "FN1 binds Collagen types I-V, VII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43888", "l": "[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine = [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854981", "l": "SHC1 in the RET complex is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987043", "l": "IL22RA1 binds JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48059", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O <=> beta-D-glucosylceramide + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444572", "l": "Zinc is an agonist of GPR39 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45193", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684261", "l": "MAP3K8 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164509", "l": "Binding of gp120 of ENV oligomer to the host CD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683925", "l": "ULK1 is dephosphorylated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45434", "l": "H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate => H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814153", "l": "ADO oxidises 2AET to HTAU (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112054", "l": "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39426", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA <=> (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40635", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23771", "l": "a fatty acyl-CoA + sphing-4-enine <=> an N-acylsphing-4-enine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551648", "l": "SUMOylation of TDG with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396009", "l": "STING binds c-di-GMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20925", "l": "a [peptide]-C-terminal (2S)-2-hydroxyglycine => a [peptide]-C-terminal amide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38695", "l": "a cardiolipin(in) = a cardiolipin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700186", "l": "Autophosphorylation of point mutants of ALK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34738", "l": "a fatty acyl-CoA + sphinganine <=> an N-acylsphinganine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18821", "l": "acetyl-CoA + choline = acetylcholine + CoA", "d": []}, {"i": "EC:2.3.1.6", "l": "\"choline O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74768", "l": "S-adenosyl-L-methionine + syringetin => 3,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018794", "l": "RHOV binds effectors at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38149", "l": "carbonyl sulfide + H(+) + hydrogen sulfide => carbon disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63126", "l": "ethanolamine + octadecanoate => H2O + N-octadecanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617683", "l": "EP300,CREBBP bind SOH-C481-FOXO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72234", "l": "chloride(out) + N-methyl-L-proline(out) + 2 Na(+)(out) <=> chloride(in) + N-methyl-L-proline(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54661", "l": "an aromatic (S)-hydroxynitrile => an aromatic aldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65782", "l": "3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55377", "l": "2 a quinol + O2 => 2 a quinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72890", "l": "O2 + polyporic acid + reduced [NADPH--hemoprotein reductase] <=> ascocorynin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20965", "l": "2-oxoglutarate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32716", "l": "(2R,3S)-3-methylmalate + NAD(+) => 2-oxobutanoate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626228", "l": "The distal appendage proteins recruit TTBK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177937", "l": "Phosphorylation of EGFR by SRC kinase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798268", "l": "TP53 and E2F4 inhibit CDC25C expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38198", "l": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161193", "l": "abacavir + AMP => abacavir monophosphate + adenosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031876", "l": "secretin receptor binding", "d": ["Binding to a secretin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14324", "l": "morphine + NADP(+) <=> H(+) + morphinone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56044", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)", "d": []}, {"i": "EC:3.2.1.210", "l": "\"endoplasmic reticulum Man8GlcNAc2 1,2-alpha-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69142", "l": "Recruitment of Dna2 endonuclease (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26091", "l": "H2O + limonene 1,2-epoxide + NAD(+) => (4S)-limonene + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53870", "l": "1-hydroxyphenazine + CO2 + H2O + NAD(+) => 2 H(+) + NADH + O2 + phenazine-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688899", "l": "Defective CSF2RA does not bind SFTPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12091", "l": "an N-acylsphing-4-enine + UDP-alpha-D-glucose <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14609", "l": "D-sorbitol + NADP(+) = H(+) + keto-L-sorbose + NADPH", "d": []}, {"i": "EC:1.1.1.289", "l": "\"sorbose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939129", "l": "miR-215 binds RUNX1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51937", "l": "2-(glutathione-S-yl)-hydroquinone + glutathione => glutathione disulfide + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42062", "l": "11-cis-retinal + H(+) + NADH => 11-cis-retinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862771", "l": "PLA2G2A binds bacterial phospholipids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50963", "l": "cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine <=> H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27653", "l": "GTP + uridine <=> GDP + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42323", "l": "a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30051", "l": "fluoroacetate + H2O = fluoride + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57356", "l": "2-oxoglutarate + chloride + H(+) + hapalindole U + O2 = CO2 + H2O + hapalindole G + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693540", "l": "MRN activates ATM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38692", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74715", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine = 3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26016", "l": "3-dehydroquinate => 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73699", "l": "ADP(in) + dATP(out) = ADP(out) + dATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67348", "l": "apigenin 7-O-beta-D-glucoside + malonyl-CoA = apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70585", "l": "1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA => a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39622", "l": "(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH <=> (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442749", "l": "CaMKK autophosphorylates in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69896", "l": "cytidine(out) + Na(+)(out) => cytidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70667", "l": "1PYR-5COOH spontaneously hydrolyses to L-GluSS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804276", "l": "ATM phosphorylates TTC5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784959", "l": "BPHL hydrolyses VACV to ACV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59698", "l": "D-cellotetraonate + H(+) => D-cellotetraono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656213", "l": "RAF1 mutants show enhanced heterodimerization with BRAF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.80", "l": "\"fructan beta-fructosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30684", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-D-mannosamine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45438", "l": "H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate => H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67904", "l": "glutaryl-CoA + H(+) + malonyl-[ACP] = 3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022911", "l": "CSPG is secreted (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41370", "l": "1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635868", "l": "ub-GLI is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0010851", "l": "cyclase regulator activity", "d": ["Binds to and modulates the activity of an enzyme that catalyzes a ring closure reaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66205", "l": "heptanoyl-CoA + O2 => (2E)-heptenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603437", "l": "Activated NTRK3 binds IRS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46107", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> corticosterone + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784620", "l": "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433418", "l": "Phosphorylation of JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10291", "l": "H2O + L-rhamnono-1,4-lactone <=> H(+) + L-rhamnonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55050", "l": "(3E,5Z)-dodecadienoate + CoA + H(+) => (3E,5Z)-dodecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451516", "l": "activated MEK2 phosphorylates ERK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679819", "l": "TBK1 binds amlexanox (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34380", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose => beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69127", "l": "Formation of the Flap Intermediate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989751", "l": "Expression of FABP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33315", "l": "a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34527", "l": "L-phenylalanine = (S)-3-amino-3-phenylpropanoate", "d": []}, {"i": "EC:5.4.3.11", "l": "\"phenylalanine aminomutase (D-beta-phenylalanine forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76014", "l": "(3R)-hydroxybutanoate tetramer + H2O <=> (3R)-hydroxybutanoate trimer + (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453183", "l": "p-Y348-SYK dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40161", "l": "NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose => H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982637", "l": "Opsins binds G alpha-t (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44749", "l": "5-amino-1-(beta-D-ribosyl)imidazole + ATP => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610732", "l": "GSK3 phosphorylates p-GLI3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635839", "l": "ULK3:SUFU dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27982", "l": "7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate", "d": []}, {"i": "EC:6.3.4.20", "l": "\"7-cyano-7-deazaguanine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51704", "l": "S-adenosyl-L-methionine + xanthohumol = 4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.339", "l": "\"xanthohumol 4-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70580", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624953", "l": "ARL13B binds INPP5E (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62515", "l": "2-oxoglutarate + melatonin + O2 <=> 2-hydroxymelatonin + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36247", "l": "(E)-anol + S-adenosyl-L-methionine = (E)-anethole + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936851", "l": "AHRR binds ARNT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928614", "l": "EFNB:GRB4 binds GIT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14112", "l": "L-proline + NADP(+) <=> 1-pyrroline-5-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016754", "l": "sinapoylglucose-malate O-sinapoyltransferase activity", "d": ["Catalysis of the reaction: (S)-malate + 1-O-sinapoyl-beta-D-glucose = D-glucose + sinapoyl (S)-malate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57509", "l": "H2O + NADP(+) + staphylopine => (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61782", "l": "keto-L-sorbose => keto-L-tagatose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65214", "l": "(2E)-dodecenoate + CoA + H(+) => (2E)-dodecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.4.-", "l": "\"Other carbon--nitrogen ligases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-982765", "l": "Growth hormone forms dimers and oligomers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34232", "l": "5-nitrosalicylate + O2 => 4-nitro-6-oxohepta-2,4-dienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030340", "l": "hyaluronate lyase activity", "d": ["Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0062156", "l": "mitochondrial ATP-gated potassium channel activity", "d": ["Enables the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13823", "l": "(S)-2-hydroxyglutarate + CO2 + succinate => 2-oxoglutarate + glutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71537", "l": "D-glucose 6-phosphate(out) + phosphate(in) => D-glucose 6-phosphate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75597", "l": "11-hydroxy-12,13-epoxy-(9Z)-octadecenoate => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948136", "l": "ULK1 Translocates to the mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433395", "l": "Dimerization of sSCF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432295", "l": "GPVI binds Fyn and Lyn (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180632", "l": "Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29013", "l": "2-oxoglutarate(out) + H(+)(out) => 2-oxoglutarate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50344", "l": "3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH = 3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+)", "d": []}, {"i": "EC:2.3.1.252", "l": "\"mycolipanoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74863", "l": "(R)-salsolinol + S-adenosyl-L-methionine = H(+) + N-methyl-(R)-salsolinol + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10885", "l": "(24R,24(1)R)-fucosterol epoxide => acetaldehyde + desmosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691167", "l": "CUL1, SKP1, FBXL5 bind (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59981", "l": "8-oxo-dGTP + H2O => 8-oxo-dGDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034559", "l": "bisphenol A hydroxylase B activity", "d": ["Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 1,2-bis(4-hydroxyphenyl)-2-propanol + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34352", "l": "(2E)-geranial + H2O + NAD(+) => geranate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047397", "l": "dolichylphosphate-glucose phosphodiesterase activity", "d": ["Catalysis of the reaction: dolichyl beta-D-glucosyl phosphate + H2O = dolichol-phosphate + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17489", "l": "H(+) + NADH + O2 + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)", "d": []}, {"i": "EC:1.14.12.7", "l": "\"phthalate 4,5-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026901", "l": "GGT transfers GSH to 16S,17S-epoxy-DHA to form PCTR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12459", "l": "CTP + D-ribitol 5-phosphate + H(+) <=> CDP-L-ribitol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16394", "l": "H2O + juvenile hormone II => H(+) + juvenile hormone II carboxylate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55021", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O => 5,6-diaminouracil + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.468544520863134", "identifiers": [{"i": "GO:0016776", "l": "phosphotransferase activity, phosphate group as acceptor", "d": ["Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)."]}, {"i": "EC:2.7.4.-", "l": "\"Phosphotransferases with a phosphate group as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72244", "l": "catechol + S-adenosyl-L-methionine => guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687875", "l": "Defective SFTPA2 does not translocate from ER membrane to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211959", "l": "CYP3A43 6b-hydroxylates TEST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682388", "l": "Autophagosome maturation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69411", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+) <=> androst-4-ene-3,11,17-trione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61242", "l": "3-phenylpyruvate + H2O2 + NH4(+) => H2O + L-phenylalanine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69152", "l": "Removal of remaining Flap (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016250", "l": "N-sulfoglucosamine sulfohydrolase activity", "d": ["Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381461", "l": "Plasmin proteolyzes IGF:IGFBP-3:ALS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944263", "l": "Association of procollagen type II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467811", "l": "Separation of sister chromatids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12403", "l": "beta-nicotinamide D-ribonucleotide + H2O <=> NH4(+) + nicotinate beta-D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75069", "l": "chloride(in) + 2 hydrogencarbonate(out) + Rb(+)(out) => chloride(out) + 2 hydrogencarbonate(in) + Rb(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71586", "l": "L-histidine(in) + Na(+)(in) <=> L-histidine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034534", "l": "1-methylnaphthalene hydroxylase activity", "d": ["Catalysis of the reaction: 1-methylnaphthalene + NADH + H+ + O2 = 1-hydroxymethylnaphthalene + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17051", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-9 => 3-demethylubiquinol-9 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24691", "l": "acetate + eugenol + NADP(+) => (E)-coniferyl acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.18", "l": "\"carboxypeptidase T\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30449", "l": "formaldehyde + H2O + NAD(+) + xanthine => 3-methylxanthine + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033730", "l": "arogenate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: L-arogenate + NADP+ = L-tyrosine + NADPH + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170120", "l": "Translocation of Cdc25B to the cytoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56992", "l": "6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = (+)-costunolide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66475", "l": "(2Z,6E,10E,14E)-geranylfarnesol <=> 18-episcalar-17(25)-en-19-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19963", "l": "a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside => a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51496", "l": "a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29763", "l": "ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) = ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847880", "l": "CYTH proteins bind ARF1:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9648017", "l": "EML4 binds to microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757578", "l": "ALB binds PREDN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112437", "l": "Formation of NELF complex  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688884", "l": "Defective CSF2RB does not bind SFTPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865994", "l": "GAB1 binds PTPN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047662", "l": "aminobenzoate decarboxylase activity", "d": ["Catalysis of the reaction: 4(or 2)-aminobenzoate = aniline + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11280", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP", "d": []}, {"i": "EC:2.1.2.8", "l": "\"deoxycytidylate 5-hydroxymethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19272", "l": "2-furoate + ATP + CoA <=> 2-furoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73608", "l": "CTP(out) + dCTP(in) => CTP(in) + dCTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35125", "l": "H(+)(in) + L-alanyl-D-glutamate(in) => H(+)(out) + L-alanyl-D-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167459", "l": "Abortive  termination of HIV-1 elongation after arrest (Tat-containing elongation complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14496", "l": "H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] <=> ADP-D-ribose + L-arginyl-[dinitrogen reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0001635", "l": "calcitonin gene-related peptide receptor activity", "d": ["Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20383", "l": "5alpha-androstan-3,17-dione + H(+) + NADH => androsterone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45943", "l": "12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007496", "l": "APAF1 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62731", "l": "(+)-malbrancheamide B + bromide + FAD + 2 H(+) <=> (+)-malbrancheamide D + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0008174", "l": "mRNA methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35736", "l": "a (2R)-2-hydroxycarboxylate + NADP(+) => a 2-oxocarboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851979", "l": "BTNL9 binds immune cell surfaces (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32741", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23958", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39381", "l": "(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+) => (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62804", "l": "2 7-demethylsiderin + NADPH + O2 = desertorin A + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050329", "l": "tetrahydroxypteridine cycloisomerase activity", "d": ["Catalysis of the reaction: tetrahydroxypteridine = H+ + xanthine-8-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52765", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O => (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61193", "l": "(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53466", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate => 1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69854", "l": "a 5,6-dihydrouridine in mRNA + NAD(+) <=> a uridine in mRNA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60047", "l": "beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625749", "l": "FOXO1,FOXO3 and SMAD3 bind TRIM63 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14639", "l": "adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate => 3'-phosphoadenylyl sulfate + a thiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396337", "l": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65644", "l": "(4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106407", "l": "Glc2Man9GlcNAc2 oligosaccharide glucosidase activity", "d": ["Catalysis of the reaction: Glc(2)Man(9)GlcNAc(2)-[protein] + H2O = GlcMan(9)GlcNAc(2)-[protein] + beta-D-glucopyranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73039", "l": "H(+)(out) + Ni(2+)(out) = H(+)(in) + Ni(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29729", "l": "acetaldehyde + FMN + 2 H(+) + H2O + sulfite => ethane-1-sulfonate + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141049", "l": "protein-glutathione oxidoreductase (glutathione) activity", "d": ["Catalysis of the reaction: glutathionylated protein (PSSG) + glutathione (GSH) = protein-thiol (PSH) + glutathione disulfide (GSSG). The reaction may proceed via a 'monothiol' or 'dithiol' mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-912790", "l": "CBL binds CRK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.3.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34127", "l": "(2E)-geranyl diphosphate + olivetolate = cannabigerolate + diphosphate", "d": []}, {"i": "EC:2.5.1.102", "l": "\"geranylpyrophosphate--olivetolic acid geranyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50621", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42711", "l": "guanosine(46) in tRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70813", "l": "D-xylulose 5-phosphate + sulfoacetaldehyde => 4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35968", "l": "fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18219", "l": "an omega-aminoaldehyde + L-glutamate => 2-oxoglutarate + an alkane-alpha,omega-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11384", "l": "(S)-2-hydroxyoctadecanoate + NAD(+) = 2-oxooctadecanoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.99", "l": "\"(S)-2-hydroxy-fatty-acid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687113", "l": "MYC mRNA translation is negatively regulated by miR-34B and C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17490", "l": "H(+) + NADH + O2 + phthalate => cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19360", "l": "H(+) + L-proline betaine + NADPH + O2 <=> formaldehyde + H2O + N-methyl-L-proline + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50813", "l": "androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25010", "l": "N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14323", "l": "H(+) + morphinone + NADPH => morphine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.39", "l": "\"FMN reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17913", "l": "H2O + NAD(+) + nitrite = H(+) + NADH + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950387", "l": "CANX binds EBI3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295622", "l": "SPRY2 binds CBL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31785", "l": "diphosphate + tuberculosinol => H2O + tuberculosinyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41361", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68274", "l": "CoA + O-fatty acyl-L-seryl-[protein] => a fatty acyl-CoA + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.7.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65081", "l": "asperaculane D + O2 + reduced [NADPH--hemoprotein reductase] => asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029476", "l": "Role of myosins in phagosome formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67605", "l": "H2O + N(6)-methyl-dATP => diphosphate + H(+) + N(6)-methyl-dAMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5681987", "l": "LC3 is cleaved by ATG4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20088", "l": "a flavonol 3-O-beta-D-glucoside + malonyl-CoA <=> a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202127", "l": "eNOS synthesizes NO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.67", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23703", "l": "5,10-methenyltetrahydrofolate + H2O <=> (6S)-10-formyltetrahydrofolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67839", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0000384", "l": "first spliceosomal transesterification activity", "d": ["Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.367", "l": "\"UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378975", "l": "Follitropin is a heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034830", "l": "(2Z)-2,4-dihydroxydec-2-enedioate aldolase activity", "d": ["Catalysis of the reaction: (2Z)-2,4-dihydroxydec-2-enedioate = pyruvate + 7-oxoheptanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609744", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2B (GRIN2B) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102454", "l": "cyanidin 3-O-galactosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin + UDP-D-galactose = cyanidin 3-O-beta-D-galactoside betaine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.388", "l": "\"glucose-6-phosphate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166220", "l": "FA anion diffuses laterally to UCP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61826", "l": "H(+) + pregnenolone 3-beta-D-glucoside + UDP => pregnenolone + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.270", "l": "\"3beta-hydroxysteroid 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010347", "l": "L-galactose-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: L-galactose-1-phosphate + H2O = L-galactose + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66852", "l": "(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635843", "l": "GLI translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75207", "l": "Ag(+)(out) = Ag(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0008661", "l": "1-deoxy-D-xylulose-5-phosphate synthase activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H+ + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38743", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48701", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol => a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24732", "l": "aniline + CO2 => anthranilate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173626", "l": "Activation of C1r (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66880", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-901047", "l": "Binding of ERp57 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63201", "l": "(10bS,4aR)-noroxomaritidine + H(+) + NADPH => (10bS,4aR)-oxomaritidine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46456", "l": "5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH = 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71706", "l": "taurocholate(out) <=> taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801101", "l": "RABGGTA binds RABGGTB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14808", "l": "ATP + D-allose <=> ADP + D-allose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097351", "l": "toxin sequestering activity", "d": ["Binding to a toxin to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52947", "l": "cholate + UDP-alpha-D-glucuronate <=> choloyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666001", "l": "Profilin:G-actin binds MKL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944240", "l": "Association of procollagen type III (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55669", "l": "11-cis-retinol--[retinol-binding protein] + NAD(+) => 11-cis-retinal--[retinol-binding protein] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622310", "l": "Activated NOD1 oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10812", "l": "H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + N-succinyl-L-glutamate + NADH", "d": []}, {"i": "EC:1.2.1.71", "l": "\"succinylglutamate-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047564", "l": "3-hydroxycyclohexanone dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxycyclohexanone + A = AH(2) + cyclohexane-1,3-dione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.60", "l": "\"CDP-abequose:alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und alpha-1,3-abequosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58609", "l": "2 L-ascorbate + N-decanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375160", "l": "NCAM1 binds to ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950314", "l": "Expression of calponin-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051675", "l": "isopullulanase activity", "d": ["Catalysis of the hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20552", "l": "2 Fe(III)-[cytochrome c] + 2 thiosulfate <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + tetrathionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58244", "l": "H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] = ADP-D-ribose + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654573", "l": "Activated FGFR1 binds SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37439", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51563", "l": "(S)-bulbocapnine + S-adenosyl-L-methionine <=> (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010815", "l": "SLITs bind keratan sulfate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051212", "l": "vanadium ion binding", "d": ["Binding to a vanadium ion (V)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21043", "l": "CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25699", "l": "H(+) + N,N-dihydroxy-L-hexahomomethionine => (E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173709", "l": "C7 binds C5b:C6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.13.1.-", "l": "\"Acting on carbon-sulfur bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32768", "l": "cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine => 2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022882", "l": "protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42837", "l": "acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH => 5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51246", "l": "(13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.40", "l": "\"serralysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40453", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047828", "l": "D-lyxose ketol-isomerase activity", "d": ["Catalysis of the reaction: D-lyxose = D-xylulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661425", "l": "BIL:ALB dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0043325", "l": "phosphatidylinositol-3,4-bisphosphate binding", "d": ["Binding to phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10875", "l": "H2O + N-acyl-L-aspartate <=> a carboxylate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62215", "l": "3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase] <=> gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678925", "l": "NR3C1 binds NR3C1 agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975040", "l": "KRAB-ZNF / KAP Interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47443", "l": "(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) <=> 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-984606", "l": "Kinesin-5 is a homotetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17342", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) => 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-606326", "l": "HJURP:CENPA complex localizes to the centromere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389762", "l": "Phosphorylation of PD-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5213466", "l": "RIPK3 is phosphorylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55442", "l": "H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20401", "l": "a beta-lactam + H2O = a substituted beta-amino acid", "d": []}, {"i": "EC:3.5.2.6", "l": "\"beta-lactamase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299318", "l": "Activation of TASK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38303", "l": "2-amino-2-deoxy-D-gluconate 6-phosphate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+)", "d": []}, {"i": "EC:4.3.1.29", "l": "\"D-glucosaminate-6-phosphate ammonia lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26182", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980047", "l": "NOTCH1 stimulates HES1 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44524", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35797", "l": "H(+) + kanamycin A + UDP => 2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34936", "l": "2 ATP + H(+) => diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102856", "l": "1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33954", "l": "ribostamycin + UDP-N-acetyl-alpha-D-glucosamine <=> 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111879", "l": "PIP2 hydrolysis (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033983", "l": "diaminobutyrate decarboxylase activity", "d": ["Catalysis of the reaction: L-2,4-diaminobutyrate + H+ = 1,3-diaminopropane + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015130", "l": "mevalonate transmembrane transporter activity", "d": ["Enables the transfer of mevalonate from one side of a membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73939", "l": "desmethyl-dehydrogriseofulvin + S-adenosyl-L-methionine = dehydrogriseofulvin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53693", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O => H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757686", "l": "SERPINA6 binds PREDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164834", "l": "Enzyme-bound ATP is released (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390593", "l": "ATP Hydrolysis By Myosin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41036", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174224", "l": "Dissociation of Cdc20 from APC/C complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74047", "l": "L-alanine(in) + L-valine(out) = L-alanine(out) + L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57224", "l": "glyoxal + GTP = N(2)-(1-hydroxy-2-oxoethyl)-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757256", "l": "MCM3 binds MCM5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112396", "l": "Separation of elongating transcript from template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033456", "l": "GCG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GCG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009072", "l": "STAT3 phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195730", "l": "Transport of processed viral proteins to the cell membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65888", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205321", "l": "Interaction of KIT and sSCF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53021", "l": "a plastoquinone + an L-alpha-amino acid + H2O => a 2-oxocarboxylate + a plastoquinol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28465", "l": "pyridoxal(in) <=> pyridoxal(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37432", "l": "12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109639", "l": "Formation of the closed pre-initiation complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021851", "l": "MECP2 binds CREB1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72803", "l": "L-arginine(out) + N(omega)-methyl-L-arginine(in) = L-arginine(in) + N(omega)-methyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64106", "l": "1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein] => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37638", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40245", "l": "3-oxohexadecanoyl-CoA + H(+) + NADH => (3R)-hydroxyhexadecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47304", "l": "(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34976", "l": "(R)-pantothenate(in) => (R)-pantothenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853801", "l": "PSPN binds RET:GFRA4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43800", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0030171", "l": "voltage-gated proton channel activity", "d": ["Enables the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5653957", "l": "Rag dimer formation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38975", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33791", "l": "H2O + sucrose 6(F)-phosphate = beta-D-fructose + beta-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40183", "l": "O2 + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37495", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57945", "l": "H(+) + H2O2 + harderoheme III => CO2 + 2 H2O + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102088", "l": "N-(4-hydroxybenzoyl)-L-glutamate synthetase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoic acid + L-glutamate + ATP <=> H+ + N-(4-hydroxybenzoyl)-L-glutamate + AMP + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43125", "l": "guanosine(10) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198599", "l": "AKT phosphorylates MDM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70123", "l": "3-dehydro-6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 6-dehydro-28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948027", "l": "RNASEs bind bacterial phospholipids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9035227", "l": "TXN2 binds CysS248-MPST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9613497", "l": "Unwinding DNA for the nascent transcript (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10704", "l": "ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)", "d": []}, {"i": "EC:6.1.1.9", "l": "\"valine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36642", "l": "3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine <=> 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57212", "l": "dGTP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381109", "l": "IRE1 binds IRE1 forming dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26065", "l": "ATP + hygromycin B => 4-O-phosphohygromycin B + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789092", "l": "NOX2 generates superoxide anion from oxygen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28355", "l": "decanoyl-CoA + FAD + H(+) => (2E)-decenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71553", "l": "5'-deoxyadenosine + 5-C(alpha)-glycyl-dTMP in DNA + A + H(+) + L-methionine => 5-N(alpha)-glycyl-dTMP in DNA + AH2 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198756", "l": "ERK1/2 phosphorylates MSK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50047", "l": "an acyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852200", "l": "Inactivation of LCK by PTPN22 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59820", "l": "2 ATP = adenosine 3'-diphosphate,5'-triphosphate + AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27853", "l": "glycine + phenylacetyl-CoA <=> CoA + H(+) + phenylacetylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52133", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O => a 5'-end 5'-monophospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47252", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36867", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76077", "l": "a dicarboxylate(out) + L-erythro-7,8-dihydrobiopterin(in) => a dicarboxylate(in) + L-erythro-7,8-dihydrobiopterin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374680", "l": "L1 trans-homophilic interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202726", "l": "F11R dimerises (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444208", "l": "MLNR (GPR38) is a receptor for motilin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39850", "l": "a 2-acylglycerol + ATP <=> a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66085", "l": "L-kynurenine + oxaloacetate => H2O + kynurenate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27672", "l": "myo-inositol + phosphate => 1D-myo-inositol 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177930", "l": "GAB1 phosphorylation by EGFR kinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19017", "l": "(6S)-NADHX + ATP = ADP + H(+) + NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000348", "l": "RANBP2 SUMOylates SP100 with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75457", "l": "(13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030798", "l": "trans-aconitate 2-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-532549", "l": "MPI isomerises Fru6P to Man6P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26131", "l": "(+)-copalyl diphosphate <=> diphosphate + isopimara-7,15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863463", "l": "STON2 binds SYT proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59709", "l": "D-maltotriono-1,5-lactone + H2O => D-maltotrionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981539", "l": "C3b binds to cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.66", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5227009", "l": "ABCF1 binds EIF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38230", "l": "(9Z)-octadecenoyl-CoA + hexadecan-1-ol <=> CoA + hexadecanyl (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629679", "l": "PDE3A inhibitors bind PDE3A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33622", "l": "ATP + CoA + tetradecanoate <=> AMP + diphosphate + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15325", "l": "an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA", "d": []}, {"i": "EC:2.3.1.15", "l": "\"glycerol-3-phosphate 1-O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2186780", "l": "Degradation of Ub-SMAD7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690449", "l": "S1PR1 bind S1P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192123", "l": "CYP27A1 27-hydroxylates CHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.19", "l": "\"(R)-specific secondary-alkylsulfatase (type III)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65995", "l": "calciol + hnu <=> 5,6-trans-vitamin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47317", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654511", "l": "FGFRL1 dimer binds FGFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36440", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0160041", "l": "neuropeptide activity", "d": ["The receptor ligand activity of any polypeptide expressed in, and secreted from a neuron."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114671", "l": "vWF binds to collagen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1169192", "l": "PTP1B dephosphorylates GHR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21742", "l": "[thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate => 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000901", "l": "translation repressor activity, non-nucleic acid binding", "d": ["Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62307", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine <=> (+)-premalbrancheamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046423", "l": "allene-oxide cyclase activity", "d": ["Catalysis of the reaction: (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (15Z)-12-oxophyto-10,15-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25724", "l": "L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.760111289607934", "identifiers": [{"i": "GO:0016706", "l": "2-oxoglutarate-dependent dioxygenase activity", "d": ["Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043854", "l": "cyclic nucleotide-gated mechanosensitive monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress and when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034482", "l": "chondroitin 2-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 2'-O-sulfate. Results in sulfation of glucuronic acid and iduronic acid residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433456", "l": "Recruitment of STATs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63381", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796368", "l": "RIPK1 binds STUB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669024", "l": "CD70 binds CD27 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483089", "l": "PE is converted to PS by PTDSS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51900", "l": "H2O + N(1)-acetylspermidine = acetate + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72688", "l": "all-trans-retinol(out) => all-trans-retinol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52633", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP => [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2169046", "l": "Degradation of TGF-beta receptor complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190263", "l": "FGFR3b binds to FGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35886", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54077", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + stellata-2,6,19-triene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40968", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60487", "l": "CTP + UTP <=> cyclic CMP-UMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34064", "l": "2-deoxystreptamine + UDP-alpha-D-glucose => 2'-deamino-2'-hydroxyparomamine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18421", "l": "acetyl-CoA + chloramphenicol = chloramphenicol 3-acetate + CoA", "d": []}, {"i": "EC:2.3.1.28", "l": "\"chloramphenicol O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70322", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O <=> 1D-myo-inositol 3,4-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917839", "l": "apo-Transferrin dissociates from the receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990649", "l": "inositol-1,2,4,5-tetrakisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,2,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,4-trisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20873", "l": "(20S)-ginsenoside Rd + UDP-alpha-D-glucose => (20S)-ginsenoside Rb1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201639", "l": "Caspase-mediated cleavage of GAS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654422", "l": "Activated FGFR4 binds FRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48065", "l": "ganglioside GD1b (d18:1(4E)) + H2O => ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429767", "l": "Passive I- efflux mediated by SMCT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674531", "l": "AAMP binds EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627107", "l": "XIAP binds CASP7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33229", "l": "4-hydroxystyrene + CO2 => (E)-4-coumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27490", "l": "2 D-sedoheptulose 7-phosphate => D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211247", "l": "Cleavage of DNA by DFF40 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669250", "l": "PAK1 phosphorylates FLNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199935", "l": "MSK1 activates CREB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49186", "l": "8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol => chlorophyllide a + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050128", "l": "N-feruloylglycine deacylase activity", "d": ["Catalysis of the reaction: N-feruloylglycine + H2O = ferulate + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71858", "l": "taurochenodeoxycholate(out) <=> taurochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35820", "l": "5,6,7,8-tetrahydromethanopterin + NADP(+) => 7,8-dihydromethanopterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647977", "l": "ICMT methylates S-Farn RAS proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450488", "l": "BRF1 Complex recruits RNA degradation activities (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322434", "l": "XIAP dissociates from ub-TLE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38863", "l": "phosphate + sucrose 6(F)-phosphate = alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate", "d": []}, {"i": "EC:2.4.1.329", "l": "\"sucrose 6(F)-phosphate phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57775", "l": "3-nitrotoluene + NADH + O2 <=> 4-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686625", "l": "LAIR1 binds collagen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31227", "l": "di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62517", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72697", "l": "Start codon recognition (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49374", "l": "H2O + NAD(+) + protoviolaceinate => H(+) + NADH + O2 + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13739", "l": "an alk-2-enal + H(+) + NADPH => an n-alkanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937419", "l": "CBR3 reduces DOX to DOXOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31885", "l": "delta-amyrin => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36778", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11900", "l": "(2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52322", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin => O2 + reduced [NADPH--hemoprotein reductase] + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54034", "l": "(6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+) => (6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29019", "l": "D-galactose(in) + H(+)(in) = D-galactose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63439", "l": "1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77094", "l": "Formation of cap binding complex (CBC) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0043515", "l": "kinetochore binding", "d": ["Binding to a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696564", "l": "USP25 deubiquitinates DDX58 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75976", "l": "(S)-stylopine + S-adenosyl-L-methionine => (S)-cis-N-methylstylopine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49444", "l": "(2-aminobenzoyl)acetyl-CoA + H2O = (2-aminobenzoyl)acetate + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.32", "l": "\"2-aminobenzoylacetyl-CoA thioesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693761", "l": "FA2H hydroxylates CERA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47396", "l": "H2O + octadecanoate ester = an aliphatic alcohol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853444", "l": "AURKA phosphorylates PHLDA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16243", "l": "a ribonucleoside 5'-diphosphate + H(+) + sucrose => an NDP-alpha-D-glucose + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3645780", "l": "TGFBR2 KD mutants do not phosphorylate TGFBR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712190", "l": "cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20677", "l": "alizarin + UDP-alpha-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.103", "l": "\"alizarin 2-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019135", "l": "deoxyhypusine monooxygenase activity", "d": ["Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11509", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 => 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13020", "l": "diphosphate + UMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749286", "l": "CDT1 binds MCM2-7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33960", "l": "2-oxoglutarate + neomycin C => 6'''-deamino-6'''-oxoneomycin C + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51438", "l": "(2R)-2-amino-4-oxopentanoate + CoA => acetyl-CoA + D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27724", "l": "4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP => di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018798", "l": "RHOV binds GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24827", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10901", "l": "an aromatic L-alpha-amino acid + glyoxylate => an aromatic oxo-acid + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0045511", "l": "interleukin-25 binding", "d": ["Binding to interleukin-25."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129353", "l": "Tropoelastin associates with microfibrils (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43311", "l": "1-hexadecanoyl-sn-glycerol + ATP <=> 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23685", "l": "(S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37119", "l": "7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine = 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)", "d": []}, {"i": "EC:2.3.1.231", "l": "\"tRNA(Phe) {7-[3-amino-3-(methoxycarbonyl)propyl]wyosine(37)-N}-methoxycarbonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23957", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2272795", "l": "Interaction of DAP12 and KIR2DS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71239", "l": "2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72925", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin III => O2 + proatranorin II + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2176452", "l": "Degradation of ubiquitinated SMAD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36134", "l": "(indol-3-yl)acetate + S-adenosyl-L-methionine <=> methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9702818", "l": "CALCR binds erenumab (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21835", "l": "3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine <=> 3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46408", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22736", "l": "5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH4(+)", "d": []}, {"i": "EC:4.3.1.4", "l": "\"formimidoyltetrahydrofolate cyclodeaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452958", "l": "Expression of SALL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165195", "l": "GTP loading by Rheb (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69678", "l": "eriodictyol-7-O-beta-D-glucoside + H2O <=> (S)-eriodictyol + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56155", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043737", "l": "deoxyribonuclease V activity", "d": ["Catalysis of the endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018746", "l": "RHOQ binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0015172", "l": "acidic amino acid transmembrane transporter activity", "d": ["Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3."]}, {"i": "REACT:R-HSA-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62273", "l": "4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9608048", "l": "Expression of PLIN1 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31866", "l": "(S)-2,3-epoxysqualene <=> friedelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201639", "l": "Caspase-mediated cleavage of GAS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59440", "l": "(-)-dehydrodiconiferyl alcohol + H(+) + NADPH = (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74052", "l": "D-threonine(out) + L-alanine(in) => D-threonine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14219", "l": "[thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein] => [thioredoxin]-disulfide + H2O + L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20737", "l": "acetyl-CoA + glycine => (2S)-2-amino-3-oxobutanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27391", "l": "pyruvate + salicylaldehyde => (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34496", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74762", "l": "isorhamnetin + S-adenosyl-L-methionine <=> 3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53716", "l": "H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP = phosphate + UDP-N-acetyl-alpha-D-muramate", "d": []}, {"i": "EC:2.7.7.99", "l": "\"N-acetyl-alpha-D-muramate 1-phosphate uridylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56015", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47786", "l": "5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749647", "l": "CES2 hydrolyzes ASA- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990838", "l": "poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends", "d": ["Catalysis of 3' exonucleolytic cleavage of poly(U), to form poly(U)-N containing a 3' uridine cyclic phosphate (U>P)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70899", "l": "histidine => urocanate + NH4+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534260", "l": "E-cadherin degradation by caspase-3 and calpain-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74907", "l": "(2E)-but-2-enoyl-AMP + holo-[ACP] = (2E)-butenoyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59612", "l": "beta-alanyl-L-ornithine + H2O = beta-alanine + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49443", "l": "(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA <=> (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030527", "l": "structural constituent of chromatin", "d": ["The action of a molecule that contributes to the structural integrity of chromatin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021944", "l": "MECP2 binds RBFOX1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36162", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin] <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043874", "l": "acireductone synthase activity", "d": ["Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21554", "l": "CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69927", "l": "adenosine(out) + Na(+)(out) = adenosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376419", "l": "Formation of NR-MED1 Coactivator Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032565", "l": "dGMP binding", "d": ["Binding to dGMP, deoxyguanosine monophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014294", "l": "RAC2 binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20619", "l": "H(+) + H2O2 + L-ascorbate => L-galactono-1,4-lactone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47027", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O <=> [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20866", "l": "beta-D-glucose 1-phosphate + D-glucose 6-phosphate => alpha,alpha-trehalose 6-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41983", "l": "3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388811", "l": "CD28 homodimer binds B7-1 homodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52915", "l": "3-dimethylallyl-4-hydroxymandelate + O2 <=> 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75850", "l": "Addition of the third nucleotide on the nascent transcript (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.3.-", "l": "\"Cyclo-ligases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22047", "l": "ATP + H(+)(in) + H2O + K(+)(out) <=> ADP + 2 H(+)(out) + K(+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59568", "l": "4-aminobutanoate + ATP + L-histidine = ADP + H(+) + L-homocarnosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67121", "l": "N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332235", "l": "CBL binds TGFBR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57591", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36070", "l": "Co-precorrin-6B + S-adenosyl-L-methionine <=> Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73903", "l": "ATP + ethanolamine + L-glutamate = ADP + gamma-L-glutamylethanolamide + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429101", "l": "HMIT co-transports myo-inositol with a proton (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430158", "l": "p-SLP-76 binds VAV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12013", "l": "ATP + thiamine => ADP + H(+) + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0052736", "l": "beta-glucanase activity", "d": ["Catalysis of the hydrolysis of linkages in beta-D-glucans; beta-glucans are polysaccharides of D-glucose monomers linked by beta-glycosidic bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45636", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787403", "l": "GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950575", "l": "IL12A:IL12B translocates from ER lumen to Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10133", "l": "ATP + benzoate + CoA => AMP + benzoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936963", "l": "IRAK2 induces TRAF6 oligomerization (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55056", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.49", "l": "\"12-hydroxyjasmonoyl-L-amino acid 12-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052685", "l": "perillic acid-CoA ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP + phosphate + perillyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784189", "l": "JAKs bind LIFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427570", "l": "Group 3 - Selective Cl- transport (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51851", "l": "8-methylmenaquinone-6 + succinate <=> 8-methylmenaquinol-6 + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050699", "l": "WW domain binding", "d": ["Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74701", "l": "(3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + H2O => (5R)-hydroxy-beta-trans-bergamotene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12960", "l": "an acetyl ester + H2O <=> acetate + an aliphatic alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31010", "l": "(S)-2,3-epoxysqualene <=> beta-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655483", "l": "USP1 autocleavage (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18812", "l": "L-alanine + oxomalonate <=> aminomalonate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40959", "l": "2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112604", "l": "Phosphorylated STATs are released (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68588", "l": "(6S)-10-formyltetrahydrofolate + GDP-alpha-D-perosamine = (6S)-5,6,7,8-tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine + H(+)", "d": []}, {"i": "EC:2.1.2.14", "l": "\"GDP-perosamine N-formyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57194", "l": "glycolate + H(+) + L-lysyl-[protein] => H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24755", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite <=> 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71554", "l": "5-N(alpha)-glycyl-dTMP in DNA + AH2 + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 5-C(alpha)-glycyl-dTMP in DNA + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864989", "l": "TFAP2A homodimer binds the TGFA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953111", "l": "E2F6 binds TFDP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49928", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428750", "l": "Gq activation by TP receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140806", "l": "SERPINC1 binds SERPINC1 activators (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878654", "l": "ACP6 hydrolyses MYS-LPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24882", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) = H(+) + L-glutamate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30255", "l": "2 a ubiquinol + O2 = 2 a ubiquinone + 2 H2O", "d": []}, {"i": "EC:1.10.3.11", "l": "\"ubiquinol oxidase (non-electrogenic)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23431", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29872", "l": "ATP + H2O + thiosulfate(out) => ADP + H(+) + phosphate + thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68622", "l": "20beta-dihydrocortisone + NADP(+) => cortisone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31417", "l": "(+)-2-epi-prezizaene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43528", "l": "L-serine + NAD(+) = 2-aminomalonate semialdehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.49", "l": "\"[pyruvate kinase]-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40962", "l": "2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine <=> 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399992", "l": "AKT1 E17K mutant phosphorylates forkhead box transcription factors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70899", "l": "histidine => urocanate + NH4+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12942", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018794", "l": "RHOV binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25589", "l": "D-threo-isocitrate + NADP(+) => (S)-oxalosuccinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390470", "l": "Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.9", "l": "\"photosystem II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051408", "l": "glyceraldehyde 3-phosphate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glyceraldehyde 3-phosphate(out) + phosphate(in) = glyceraldehyde 3-phosphate(in) + phosphate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53416", "l": "8-amino-8-demethylriboflavin + S-adenosyl-L-methionine = 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.45", "l": "\"homospermidine synthase (spermidine-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74313", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + CoA + H(+) => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61878", "l": "1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55645", "l": "ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] => ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58767", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452097", "l": "Recruited STAT5 is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39523", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA = (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928640", "l": "PAKs phosphorylate MLC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0030169", "l": "low-density lipoprotein particle binding", "d": ["Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624948", "l": "KIF17 enters the cilium (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54195", "l": "L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209167", "l": "Phosphorylated REL is cleaved by and dissociates from DREDD in the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63066", "l": "3 CO2 + 4 CoA + tetraacetate lactone => acetyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801675", "l": "PLK2 phosphorylates NPM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700648", "l": "Active ALK binds SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163090", "l": "Elongation Of The Telomeric Chromosome End (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67500", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16955", "l": "L-glutamate + N-succinyl-L-glutamate 5-semialdehyde => 2-oxoglutarate + N(2)-succinyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22379", "l": "uridine(38/39/40) in tRNA <=> pseudouridine(38/39/40) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51114", "l": "20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675947", "l": "TNFSF18 binds TNFRSF18 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60183", "l": "ATP + D-fructose(out) + H2O <=> ADP + D-fructose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32196", "l": "abieta-7,13-dien-18,18-diol => abieta-7,13-dien-18-al + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28819", "l": "5-dehydro-D-gluconate(in) + H(+)(in) = 5-dehydro-D-gluconate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036055", "l": "protein-succinyllysine desuccinylase activity", "d": ["Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD+ = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:47668", "l": "H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67312", "l": "(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = myceliothermophin E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002440", "l": "Removal of fibrillar collagen C-propeptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432036", "l": "Aquaporin-6 passively transports anions out of vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139917", "l": "tBID activates BAX protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.64", "l": "\"3-demethylubiquinol 3-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16923", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41608", "l": "3'-phosphoadenylyl sulfate + alpha,alpha-trehalose = 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)", "d": []}, {"i": "EC:2.8.2.37", "l": "\"trehalose 2-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35088", "l": "H2O + N'-monoacetylchitobiose-6'-phosphate => D-glucosamine + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71634", "l": "phosphate(in) + sulfate(out) <=> phosphate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692867", "l": "HRH3 binds pitosilant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22983", "l": "a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] <=> a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166387", "l": "The FA anion diffuses away laterally from UCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804741", "l": "MDM2 forms homo- or heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51479", "l": "a ribonucleoside 5'-triphosphate + formate + H(+) <=> a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58081", "l": "1-docosanoylglycerol + H2O => docosanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45667", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0015574", "l": "trehalose transmembrane transporter activity", "d": ["Enables the transfer of trehalose from one side of a membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens."]}, {"i": "RHEA:17629", "l": "alpha,alpha-trehalose(in) = alpha,alpha-trehalose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40015", "l": "(+)-copalyl diphosphate + H2O = 13-epi-manool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-481044", "l": "Surface deployment of platelet alpha granule membrane components (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11416", "l": "2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose", "d": []}, {"i": "EC:2.3.1.90", "l": "\"beta-glucogallin O-galloyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24232", "l": "2-dehydro-3-deoxy-D-gluconate + NAD(+) = 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.127", "l": "\"2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209566", "l": "TRAF6 is auto-ubiquitinated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381612", "l": "GLP1R binds GLP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395364", "l": "LTBP4 binds TGF-Beta-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40266", "l": "(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) <=> 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53768", "l": "allocholate + allodeoxycholoyl-CoA = allocholoyl-CoA + allodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54168", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25993", "l": "(2E,6E)-farnesyl diphosphate => (+)-epi-isozizaene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55070", "l": "a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018777", "l": "1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity", "d": ["Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48588", "l": "2 H2O + 2 leukotriene A4 + O2 = 2 lipoxin B4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660622", "l": "IL1B gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44532", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236948", "l": "Antigen processing by cathepsin S in endosoytic vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.83", "l": "\"oligopeptidase B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805103", "l": "AURKA phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080069", "l": "7-methylthioheptyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 7-methylthioheptyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 7-methylthioheptyl-glucosinolate + adenosine 3',5'-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72267", "l": "chloride(out) + formate(in) = chloride(in) + formate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71515", "l": "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018754", "l": "GDIs bind RHOH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114264", "l": "Translocation of activated BAX to the mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55950", "l": "AH2 + NH4(+) + pyruvate => A + D-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48191", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052848", "l": "inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity", "d": ["Catalysis of the reaction: 3,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22666", "l": "1,2-di-O-sinapoyl beta-D-glucose + D-glucose => 2 1-O-(trans-sinapoyl)-beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39160", "l": "(3R)-hydroxyhexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18018", "l": "H(+) + indole-3-pyruvate => CO2 + indole-3-acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13721", "l": "H2O + testololactone = H(+) + testolate", "d": []}, {"i": "EC:3.1.1.37", "l": "\"steroid-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828032", "l": "SOX17 and TFAP2C bind the POU5F1 (OCT4) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159796", "l": "Furin cleaves pro-factor IX to factor IX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35229", "l": "H(+)(in) + rifampicin(out) => H(+)(out) + rifampicin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57962", "l": "dimethyl sulfoxide + H2O + NAD(+) => dimethyl sulfide + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951951", "l": "RUNX3 binds EP300 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43241", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209840", "l": "Two DITs combine to form thyroxine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21312", "l": "2,5-dihydroxybenzoate + H(+) = CO2 + hydroquinone", "d": []}, {"i": "EC:4.1.1.62", "l": "\"gentisate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37657", "l": "1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43178", "l": "5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9017817", "l": "Gamma-secretase cleaves YBX1:NOTCH3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19214", "l": "acetyl-CoA + an S-substituted L-cysteine => an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678920", "l": "TLR processing at low pH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28232", "l": "(+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74296", "l": "n H(+)(out) + serotonin(in) => n H(+)(in) + serotonin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28990", "l": "H(+)(in) + N-acetylneuraminate(in) <=> H(+)(out) + N-acetylneuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354077", "l": "Integrin alphaIIb beta3 activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665407", "l": "PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35817", "l": "4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate => 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0097642", "l": "calcitonin family receptor activity", "d": ["Combining with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73968", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209157", "l": "Phosphorylated BSK kinase is dephosphorylated and deactivated by PUC phosphatase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36814", "l": "acetyl-CoA + GDP-alpha-D-perosamine <=> CoA + GDP-N-acetyl-alpha-D-perosamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2509831", "l": "ITPA hydrolyses XTP to XMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234166", "l": "Nuclear PHD1,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22919", "l": "4'-hydroxyacetophenone + H(+) + NADPH + O2 <=> 4-acetoxyphenol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55408", "l": "[phosphate](n) + CTP = [phosphate](n+1) + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43714", "l": "diphosphate + dodecanoyl-AMP => ATP + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11094", "l": "dihydroxyacetone phosphate + H(+) + NADH => NAD(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64413", "l": "H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) => H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33287", "l": "A + spermidine = 1-pyrroline + AH2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033890", "l": "ribonuclease D activity", "d": ["Catalysis of the exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018768", "l": "RHOU auto-activates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47149", "l": "a ubiquinone + caffeine + H2O => 1,3,7-trimethylurate + a ubiquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69598", "l": "Ubiquitination of phosphorylated Cdc25A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16052", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole <=> adenosylcob(III)alamin + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43597", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 => 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102151", "l": "3-oxo-myristate decarboxylase activity", "d": ["Catalysis of the reaction: 3-oxo-myristate + H+ <=> 2-tridecanone + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173739", "l": "Spontaneous hydrolysis of C3 thioester (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982792", "l": "Growth hormone receptor binds JAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64786", "l": "2-aminoprop-2-enoate + ethanethiol => S-ethyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382055", "l": "Grb7 binds to the active PDGF receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419011", "l": "Transhomodimerization of Nectins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74078", "l": "H(+) + NADH + phylloquinone <=> NAD(+) + phylloquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65347", "l": "H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA <=> (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901242", "l": "ABC-type doxorubicin transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + doxorubicin(in) = ADP + phosphate + doxorubicin(out)."]}, {"i": "TCDB:3.A.1.105.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72117", "l": "glycine betaine(in) + Na(+)(in) => glycine betaine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428609", "l": "Type I Na+-coupled phosphate co-transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928641", "l": "PAK binds RAC and bPIX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64450", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033422", "l": "CCC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CCC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805730", "l": "SETD9 methylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827864", "l": "Expression of CBFA2T2 in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112430", "l": "Formation of P-TEFb complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624112", "l": "CEBPA binds CDK4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33119", "l": "(2E,6E)-farnesyl diphosphate = (+)-sativene + diphosphate", "d": []}, {"i": "EC:4.2.3.129", "l": "\"(+)-sativene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750666", "l": "ALB binds ST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42723", "l": "S-adenosyl-L-methionine + uridine(2552) in 23S rRNA <=> 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65017", "l": "chlorothalonil + H2O => 4-hydroxychlorothalonil + chloride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26253", "l": "H(+) + isopimara-7,15-dienol + NADPH + O2 = 2 H2O + isopimara-7,15-dienal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40620", "l": "H2O + tridodecanoylglycerol => 2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811454", "l": "MAPKs phosphorylate PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-996755", "l": "ZFPM proteins bind GATA proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062061", "l": "TAP complex binding", "d": ["Binding to a TAP complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450325", "l": "c-FOS activation by phospho ERK1/2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34862", "l": "3-oxocyclopentanecarbonitrile + 2 H2O <=> 3-oxocyclopentanecarboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58988", "l": "(E)-4-hydroxynon-2-enal + H2O + O2 = (E)-4-hydroxynon-2-enoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36291", "l": "3-methylxanthine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24615", "l": "17beta-estradiol + NAD(+) <=> estrone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432121", "l": "LDL binds to LRP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956568", "l": "RUNX1 binds the core TAL1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694433", "l": "MIA2 binds PREB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055041", "l": "cyclopentanol dehydrogenase activity", "d": ["Catalysis of the reaction: cyclopentanol + NAD+ = cyclopentanone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62423", "l": "a (R)-2-hydroxy fatty acid + O2 <=> a fatty acid + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247844", "l": "WNT ligands traffic to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050138", "l": "nicotinate dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NADP+ + nicotinate = 6-hydroxynicotinate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40406", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73806", "l": "AIR + CO2 => CAIR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38006", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate <=> 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62478", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+) => 3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75630", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + H2O <=> ectocarpin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65378", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005168", "l": "neurotrophin TRKA receptor binding", "d": ["Binding to a neurotrophin TRKA receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13561", "l": "H2O + meso-2,6-diaminoheptanedioate + NADP(+) = (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)", "d": []}, {"i": "EC:1.4.1.16", "l": "\"diaminopimelate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61587", "l": "cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59478", "l": "2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol => 2 AH2 + 2 ATP + benzoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655955", "l": "OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222128", "l": "NOC2L binds TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709109", "l": "DHFR dimer binds DHFR inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53316", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.348", "l": "\"N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67854", "l": "FMN-N(5)-peroxide => FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19364", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate <=> (2E,6E)-farnesyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70598", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103036", "l": "NADH:menaquinone oxidoreductase activity", "d": ["Catalysis of the reaction: 5 H+ + NADH + a menaquinone <=> 4 H+ + NAD + a menaquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-593685", "l": "Netrin-4 binds DCC/UNC5A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1980125", "l": "ITCH binds DTX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65196", "l": "H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine = H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43418", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71408", "l": "7beta-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] => 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.276", "l": "\"gibberellin A4 carboxyl methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0030984", "l": "kininogen binding", "d": ["Binding to a kininogen, a kinin precursor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20543", "l": "2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+) => H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19563", "l": "H2O + NADP(+) + testololactone => androst-4-ene-3,17-dione + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76008", "l": "(3R)-hydroxybutanoate pentamer + H2O => (3R)-hydroxybutanoate tetramer + (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987015", "l": "IL20 binds IL20RA:JAK1:IL20RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17522", "l": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) => ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44089", "l": "ATP + CoA + heptanoate => AMP + diphosphate + heptanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76095", "l": "(11R)-19-oxocarlactone + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-carlactonoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008261", "l": "allatostatin receptor activity", "d": ["Combining with allatostatin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61547", "l": "ent-kaur-16-en-19-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ent-kaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33307", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] = (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.195", "l": "\"protein-N(pi)-phosphohistidine--2-O-alpha-mannosyl-D-glycerate phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17957", "l": "3-oxopropanoate = H2O + propynoate", "d": []}, {"i": "EC:4.2.1.27", "l": "\"acetylenecarboxylate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26508", "l": "(9Z)-octadecenoate + NH4(+) => (9Z)-octadecenamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16821", "l": "6-phospho-D-gluconate + NAD(+) = 6-phospho-2-dehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64113", "l": "an N-acyl-L-phenylalanine + H2O => a fatty acid + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419011", "l": "Transhomodimerization of Nectins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48152", "l": "ganglioside GD1b(d18:1(4E)/18:0) + H2O = ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54377", "l": "(+)-copalyl diphosphate + H2O => diphosphate + nezukol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549129", "l": "OCT1 transports organic cations into hepatic cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381461", "l": "Plasmin proteolyzes IGF:IGFBP-3:ALS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12461", "l": "(S)-malate => fumarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19897", "l": "H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide", "d": []}, {"i": "EC:1.14.13.39", "l": "\"nitric-oxide synthase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55895", "l": "a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 <=> a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68781", "l": "(2Z,6Z)-farnesyl diphosphate => alpha-humulene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18560", "l": "1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA <=> 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61966", "l": "a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35248", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(in) + ATP + H2O => ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14795", "l": "2-oxoadipate + H(+) + NADH => 2-hydroxyadipate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22475", "l": "(R)-pantetheine + ATP <=> (R)-4'-phosphopantetheine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74690", "l": "a 2,3-di-O-phytanyl-sn-glycerophospholipid + AH2 + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + A + a macrocyclic archaeaol phospholipid + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33751", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": []}, {"i": "EC:3.1.3.27", "l": "\"phosphatidylglycerophosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351913", "l": "Caspase-mediated cleavage of TJP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0009009", "l": "site-specific recombinase activity", "d": ["Catalysis of the formation of new phosphodiester bonds between a pair of short, unique target DNA sequences."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53065", "l": "2-methoxyestrone + UDP-alpha-D-glucuronate => 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65671", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42004", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047105", "l": "4-trimethylammoniobutyraldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952419", "l": "SMURFs ubiquitinate RUNX3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700168", "l": "Active ALK phosphorylates IRS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17491", "l": "cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) => H(+) + NADH + O2 + phthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46446", "l": "(10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O => (11Z)-hexadecenoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873850", "l": "STARD5 binds DCA, LCA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63807", "l": "GDP-beta-L-gulose <=> GDP-beta-L-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11272", "l": "a (2R)-2-hydroxycarboxylate + a quinone = a 2-oxocarboxylate + a quinol", "d": []}, {"i": "EC:1.1.5.10", "l": "\"D-2-hydroxyacid dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.863640214551324", "identifiers": [{"i": "GO:0015252", "l": "proton channel activity", "d": ["Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}, {"i": "REACT:R-HSA-9729542", "l": "OTOP1 transports H+ from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13863", "l": "D-xylono-1,5-lactone + H(+) + NADH => D-xylose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012835", "l": "GDIs block activation of RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875451", "l": "MET phosphorylates CBL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625346", "l": "SREBF1 gene expression is inhibited by FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805730", "l": "SETD9 methylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14247", "l": "AMP + diphosphate + H(+) => ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605428", "l": "Expression of ESRRA (ERR1, ERRalpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9716947", "l": "ESR1 binds ESR1 agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44206", "l": "2-hydroxyhexadecanoyl-CoA + AMP + diphosphate => 2-hydroxyhexadecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75685", "l": "(12R,13S)-epoxy-(10R)-hydroperoxy-(8E)-octadecenoate => (12R,13S)-epoxy-(9Z)-octadecenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140842", "l": "n fibrin monomers -> fibrin multimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.863640214551324", "identifiers": [{"i": "GO:0017046", "l": "peptide hormone binding", "d": ["Binding to a peptide with hormonal activity in animals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446077", "l": "BP230 interacts with keretin K5/K14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74428", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + H(+)(out) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33687", "l": "3'-N-debenzoyltaxol + benzoyl-CoA = CoA + H(+) + taxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21932", "l": "S-adenosyl-L-methionine = L-homoserine lactone + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:4.4.1.42", "l": "\"S-adenosyl-L-methionine lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052858", "l": "peptidyl-lysine acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl phosphate + peptidyl-L-lysine = phosphate + peptidyl-N6-acetyl-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15709", "l": "kaempferol + UDP-alpha-D-galactose = H(+) + kaempferol 3-O-beta-D-galactoside + UDP", "d": []}, {"i": "EC:2.4.1.234", "l": "\"kaempferol 3-O-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13869", "l": "NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH", "d": []}, {"i": "EC:1.3.1.12", "l": "\"prephenate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33047", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] = (+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": []}, {"i": "EC:1.14.15.10", "l": "\"(+)-camphor 6-endo-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45260", "l": "tetracosanoate(out) = tetracosanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852362", "l": "GTSE1 binds CDKN1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19533", "l": "2 H(+) + 2 H2O + N(2)-succinyl-L-arginine = CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)", "d": []}, {"i": "EC:3.5.3.23", "l": "\"N-succinylarginine dihydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51469", "l": "(R)-lactate + a quinone => a quinol + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38286", "l": "itaconate + succinyl-CoA <=> itaconyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36725", "l": "2-phenylacetaldehyde + AH2 + NH4(+) => 2-phenylethylamine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36492", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA => (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52458", "l": "H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP => testosterone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57813", "l": "1-chloro-2-nitrobenzene + NADH + O2 => 3-chlorocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202129", "l": "HSP90 binds eNOS:Caveolin-1:CaM complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50470", "l": "19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+) => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665286", "l": "Resistant ERBB2 KD mutants do not bind neratinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54403", "l": "1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52608", "l": "2-hydroxybutanoate + NADP(+) = 2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796626", "l": "MIB2 ubiquitinates CFLAR  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37289", "l": "ADP + H(+) + L-alanyl-L-leucine(in) + phosphate => ATP + H2O + L-alanyl-L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004850", "l": "uridine phosphorylase activity", "d": ["Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23506", "l": "(R)-1-aminopropan-2-ol + adenosylcob(III)yrate => adenosylcob(III)inamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51709", "l": "D-altritol + NAD(+) => H(+) + keto-D-tagatose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28411", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) => 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727349", "l": "XDH dehydrogenates xanthine to form urate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9612501", "l": "SGK phosphorylates CREB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.18", "l": "\"dolichyl-diphosphooligosaccharide--protein glycotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0003997", "l": "acyl-CoA oxidase activity", "d": ["Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784734", "l": "PCSK9 binds LDLR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205231", "l": "Dimerization of KIT upon SCF binding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14626", "l": "[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) => [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.8.-", "l": "\"With a flavin as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299338", "l": "Activation of TRESK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60176", "l": "5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA + H2O = 5-methylaminomethyl-2-selenouridine(34) in tRNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51767", "l": "dimethylallyl diphosphate + phlorisovalerophenone <=> 4-prenylphlorisovalerophenone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.50567595061159", "identifiers": [{"i": "GO:0003916", "l": "DNA topoisomerase activity", "d": ["Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38617", "l": "ADP-D-ribose => cyclic ADP-beta-D-ribose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61720", "l": "a D-guloside + NAD(+) = a 3-dehydro-D-guloside + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61927", "l": "(2S,4R)-ketoconazole(in) + ATP + H2O <=> (2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31840", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-3-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3878123", "l": "Initiation of SAHF formation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54946", "l": "(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+) => 3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65650", "l": "a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112395", "l": "Abortive termination of elongation after arrest (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15381", "l": "O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO", "d": []}, {"i": "EC:1.13.11.24", "l": "\"quercetin 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707523", "l": "Hemes bind to BACH1:MAFK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66775", "l": "ATP + H2O + uroporphyrin I(in) <=> ADP + H(+) + phosphate + uroporphyrin I(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373751", "l": "UNC-5 binds Netrin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22719", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173709", "l": "C7 binds C5b:C6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21526", "l": "(2S)-2-isopropylmalate + CoA + H(+) => 3-methyl-2-oxobutanoate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38241", "l": "1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA => (9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55746", "l": "coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n) => coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848124", "l": "PTK6 phosphorylates STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38905", "l": "a sphingomyelin(out) + ADP + H(+) + phosphate => a sphingomyelin(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029454", "l": "Autophosphorylation of PAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212356", "l": "Formation of CSL-NICD coactivator complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49420", "l": "ATP + valienone = ADP + H(+) + valienone 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247960", "l": "Activation of p38 MAPK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19168", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose <=> 1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46469", "l": "an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O => ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250875", "l": "botF:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65907", "l": "3-hydroxy-L-kynurenine + glyoxylate <=> 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693593", "l": "D-loop extension by DNA polymerases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13584", "l": "N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638222", "l": "Defective SLC2A2 does not transport Fru, Gal, Glc from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50821", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) => H(+) + NADPH + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047304", "l": "2-aminoethylphosphonate-pyruvate transaminase activity", "d": ["Catalysis of the reaction: (2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46051", "l": "D-galactosamine 6-phosphate <=> alpha-D-galactosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71942", "l": "2-oxoglutarate(out) + 3 Na(+)(out) <=> 2-oxoglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047966", "l": "glycosulfatase activity", "d": ["Catalysis of the reaction: D-glucose 6-sulfate + H2O = D-glucose + H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55954", "l": "a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+) => an inositol-1-phosphoceramide + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68487", "l": "(2R)-2-hydroperoxydodecanoate + H(+) <=> CO2 + H2O + undecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200406", "l": "CPT1A,B transfers PALM to CAR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-398185", "l": "LARG binds plexin B1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39391", "l": "(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH = (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102165", "l": "(Z)-3-hexen-1-ol acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + (Z)-hex-3-en-1-ol <=> (3Z)-hex-3-en-1-yl acetate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14348", "l": "H(+) + L-tyrosine <=> CO2 + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247510", "l": "MARCO:ligand is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.7.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033233", "l": "PEX5S,L binds cargo proteins containing PTS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68711", "l": "(2E)-geranyl diphosphate + H2O <=> diphosphate + linalool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69591", "l": "inosine + UMP <=> IMP + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25178", "l": "4-methyl-2-oxopentanoate + CoA + NAD(+) => 3-methylbutanoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49005", "l": "aurachin C + H(+) + NADPH + O2 => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44152", "l": "1D-myo-inositol 2-phosphate + H2O = myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60025", "l": "(R,R)-chrysanthemyl diphosphate + H2O => (R,R)-chrysanthemol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209566", "l": "TRAF6 is auto-ubiquitinated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37660", "l": "anthraniloyl-CoA + methanol => CoA + O-methyl anthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57941", "l": "Fe-coproporphyrin III + H(+) + H2O2 => CO2 + 2 H2O + harderoheme III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70480", "l": "H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+) => 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667563", "l": "AVPR2 bind desmopressin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68189", "l": "dodecanoyl-CoA + phytol => CoA + dodecanoate phytyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39577", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+) => 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48692", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61812", "l": "3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose = dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24014", "l": "(+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine => gamma-tocopherol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693148", "l": "BCKDK phosphorylates BCKDH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350385", "l": "DSH binds to RAC1:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102392", "l": "decanoate-[HmqF protein] ligase activity", "d": ["Catalysis of the reaction: decanoate + ATP(4-) + an HmqF protein <=> AMP(2-) + diphosphoric acid + a decanoyl-HmqF protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614369", "l": "Transport of HCMV DNA Into the Nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20510", "l": "ATP + viomycin => ADP + H(+) + O-phosphoviomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592436", "l": "Initial activation of proMMP9 by MMPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66000", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+)", "d": []}, {"i": "EC:2.1.1.378", "l": "\"[methyl-Co(III) glycine betaine-specific corrinoid protein]--tetrahydrofolate methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37504", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12119", "l": "A + H2 <=> AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38911", "l": "avenacoside B + H2O = 26-desgluco-avenacoside B + D-glucose", "d": []}, {"i": "EC:3.2.1.188", "l": "\"avenacosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43033", "l": "3-chloro-D-alanine => 2-aminoprop-2-enoate + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61964", "l": "a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39529", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+) => (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956659", "l": "ABL1 phosphorylates YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48471", "l": "ganglioside GM1b (d18:1(4E)) + H2O <=> ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956568", "l": "RUNX1 binds the core TAL1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14851", "l": "L-aspartate + urea => H2O + N-amidino-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51968", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51409", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41464", "l": "ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.70", "l": "\"ent-sandaracopimaradiene 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5333678", "l": "CPNEs bind PL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75081", "l": "Formation of AT-AC B Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004572", "l": "mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661217", "l": "MT1A binds zinc (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102695", "l": "UDP-glucose:cis-zeatin 7-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cis-zeatin <=> H+ + cis-zeatin-7-N-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014296", "l": "RAC2 GEFs activate RAC2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65101", "l": "a 1-acylglycerol + hexadecanoyl-CoA => an hexadecanoyl-acylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63165", "l": "H2O + N-tricosanoyl-taurine => taurine + tricosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10687", "l": "H2O + O-phospho-L-tyrosyl-[protein] <=> L-tyrosyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75717", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + pantetheine 4'-phosphate => CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0042910", "l": "xenobiotic transmembrane transporter activity", "d": ["Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18792", "l": "D-glucosamine 6-phosphate <=> D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48856", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102424", "l": "sesaminol-2-O-gentiobioside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: (+)-sesaminol 2-O-beta-D-gentiobioside + UDP-alpha-D-glucose <=> (+)-sesaminol 2-O-beta-D-gentiotrioside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450474", "l": "MK2 phosphorylates BRF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74806", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-374909", "l": "Metabolism of Noradrenaline (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.652932776586212", "identifiers": [{"i": "GO:0032451", "l": "demethylase activity", "d": ["Catalysis of the removal of a methyl group from a substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18110", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58875", "l": "24-methylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31506", "l": "beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate <=> 4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17685", "l": "H(+) + uracil 5-carboxylate = CO2 + uracil", "d": []}, {"i": "EC:4.1.1.66", "l": "\"uracil-5-carboxylate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41090", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805943", "l": "S100A1 binds TLR4:LY96 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13198", "l": "H(+) + sulfite + UDP-alpha-D-glucose => H2O + UDP-alpha-D-6-sulfoquinovose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30606", "l": "15-cis-phytoene + A <=> AH2 + all-trans-phytofluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683964", "l": "ATM phosphorylates EYA1-4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10873", "l": "H2O + N-acyl-L-aspartate => a carboxylate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0008252", "l": "nucleotidase activity", "d": ["Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15872", "l": "2-oxoglutarate + D-alanine <=> D-glutamate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296309", "l": "HCAR3 binds HCAR3 ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705584", "l": "HMGCR dimer binds statins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21234", "l": "NH4(+) + trans-urocanate => L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36305", "l": "a long-chain primary fatty alcohol + CoA + 2 NADP(+) => a fatty acyl-CoA + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51421", "l": "a (2S,3S)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55883", "l": "apo-[aequorin]--coelenterazine + O2 <=> [aequorin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186773", "l": "PDGF dimer binds two receptors simultaneously (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19176", "l": "H(+) + NADH + naphthalene + O2 <=> (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1900995", "l": "ubiquinone-6 binding", "d": ["Binding to ubiquinone-6. Ubiquinone-6 is a ubiquinone compound having a (2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl substituent at position 2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67661", "l": "an (11Z)-eicosenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (8Z,11Z)-eicosadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204364", "l": "ROBO1 binds SLIT2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18088", "l": "coenzyme B + coenzyme M + methanophenazine <=> coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67628", "l": "ATP + dGMP + L-aspartate = (2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate", "d": []}, {"i": "EC:6.3.4.25", "l": "\"2-amino-2'-deoxyadenylo-succinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54798", "l": "an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH => a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.2.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173542", "l": "SMURF2 ubiquitinates SMAD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30158", "l": "FADH2 + 2 Fe(3+) <=> FAD + 2 Fe(2+) + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40388", "l": "1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP => 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70587", "l": "H2O + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) = acetate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193636", "l": "p75NTR interacts with the NOGO receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53269", "l": "L-ribulose => L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12491", "l": "2-amino-2-deoxy-D-gluconate <=> 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66906", "l": "AH2 + cannabichromenate => A + cannabinerolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21689", "l": "a polyvinyl alcohol + n O2 => an oxidized polyvinyl alcohol + n H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49147", "l": "2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944232", "l": "Association of procollagen type XII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31878", "l": "(S)-2,3-epoxysqualene <=> marneral", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48397", "l": "(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine => 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004938", "l": "alpha2-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48828", "l": "H(+) + NADPH + O2 + resorcinol = benzene-1,2,4-triol + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.219", "l": "\"resorcinol 4-hydroxylase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45964", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O = 2 AMP + ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71164", "l": "homogentisate + O2 => maleylacetoacetate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798044", "l": "BTG2 binds CCR4-NOT complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35973", "l": "diphosphate + fumitremorgin B => 12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374919", "l": "Noradrenaline clearance from the synaptic cleft (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39926", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41696", "l": "1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433374", "l": "Processing of SCF isoform 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616116", "l": "EGR2 and SOX10 bind the MAG gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036456", "l": "L-methionine-(S)-S-oxide reductase activity", "d": ["Catalysis of the reaction: L-methionine (S)-S-oxide + thioredoxin -> L-methionine + thioredoxin disulfide + H2O."]}, {"i": "RHEA:19995", "l": "[thioredoxin]-dithiol + L-methionine (S)-S-oxide => [thioredoxin]-disulfide + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013158", "l": "CDC42 GDIs block activation of CDC42 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36281", "l": "3-methylxanthine + formaldehyde + H2O + NAD(+) => H(+) + NADH + O2 + theophylline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0043178", "l": "alcohol binding", "d": ["Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809764", "l": "SBF1 binds MTMR2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27468", "l": "ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) <=> ADP-D-glycero-beta-D-manno-heptose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71975", "l": "glutathione(out) + 3 Na(+)(out) = glutathione(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41132", "l": "1-decanoyl-sn-glycero-3-phosphocholine + H2O => 1-decanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805507", "l": "APAF1 binds AVEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22657", "l": "CDP-ethanolamine + L-serine => CMP + H(+) + L-serine-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.301", "l": "\"2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047471", "l": "maltose alpha-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: maltose = trehalose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39492", "l": "(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH => (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.235616146829116", "identifiers": [{"i": "GO:0005242", "l": "inward rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62889", "l": "GDP-beta-L-fucose + lactose => beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029454", "l": "Autophosphorylation of PAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52493", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70557", "l": "L-seryl-[protein] + N-acetyl-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28942", "l": "H(+)(in) + xanthosine(in) <=> H(+)(out) + xanthosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71632", "l": "phosphate(in) + sulfate(out) => phosphate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39693", "l": "(11Z)-octadecenoyl-CoA + NADP(+) => (2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158860", "l": "SULT1A1 dimer sulfonates NHABP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65558", "l": "an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc => globoside GalGb4Cer + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0043225", "l": "ATPase-coupled inorganic anion transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + inorganic anion(out) = ADP + phosphate + inorganic anion(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420977", "l": "Ca permeable AMPA receptor ligand binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56136", "l": "2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O", "d": []}, {"i": "EC:1.11.1.7", "l": "\"peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070320", "l": "inward rectifier potassium channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of an inwardly rectifying potassium channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934819", "l": "Cytoplasmic proteases cleave Profilaggrin producing Filaggrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018808", "l": "RAC3 binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51891", "l": "2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17961", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = H2O + leukotriene A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.20", "l": "\"cathepsin G\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40759", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34848", "l": "7,8-dihydromonapterin + H(+) + NADPH => 5,6,7,8-tetrahydromonapterin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839110", "l": "p-BCR-p-FGFR1 phosphorylates GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-398184", "l": "LARG activation by G alpha 12/13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54125", "l": "coelenterazine h dioxetanone => CO2 + excited coelenteramide h monoanion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12293", "l": "ATP + L-serine + tRNA(Ser) => AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140259", "l": "PRC1 complex binding", "d": ["Binding to a PRC1 complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875374", "l": "MET binds LRIG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50326", "l": "1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199093", "l": "CXADR binds to AMICA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12354", "l": "H2O2 + L-xylo-hex-3-ulonolactone => L-gulono-1,4-lactone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0003842", "l": "1-pyrroline-5-carboxylate dehydrogenase activity", "d": ["H2O + L-glutamate 5-semialdehyde + NAD+ = 2 H+ + L-glutamate + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050037", "l": "L-xylose 1-dehydrogenase activity", "d": ["Catalysis of the reaction: aldehydo-L-xylose + NADP+ = L-xylono-1,4-lactone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614591", "l": "Excess cysteine yields lanthionine and H2S (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56728", "l": "4-hydroxy-all-trans-beta-carotene + AH2 + O2 = 4,4-dihydroxy-all-trans-beta-carotene + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429860", "l": "DCP1-DCP2 complex decaps mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.30", "l": "\"acyl-lipid (8-3)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48198", "l": "reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA => H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031697", "l": "beta-1 adrenergic receptor binding", "d": ["Binding to a beta-1 adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605724", "l": "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203973", "l": "Vesicle budding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-141437", "l": "Formation of the MCC complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37393", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981931", "l": "RAC1 and CDC42 activate PAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25601", "l": "4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O = 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72497", "l": "glutarate(out) + prostaglandin E2(in) => glutarate(in) + prostaglandin E2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68052", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+)", "d": []}, {"i": "EC:4.6.1.19", "l": "\"ribonuclease T2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730902", "l": "Oligomerization of p-CARMA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69706", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphingosine + H2O <=> beta-D-galactose + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71705", "l": "taurocholate(in) => taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48842", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25941", "l": "8-chloroquinoline + A + H2O => 8-chloroquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3928620", "l": "PAK1 autophosphorylates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21481", "l": "2-furoyl-CoA + A + H2O => 5-hydroxy-2-furoyl-CoA + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55260", "l": "2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74749", "l": "3-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine => myricetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16152", "l": "beta-nicotinamide D-ribonucleotide + diphosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55947", "l": "2-chloroethanol + 2 Fe(III)-[cytochrome c] <=> chloroacetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451283", "l": "kainate receptor binds glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15751", "l": "AH2 + phenylglyoxylate => (S)-mandelate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71404", "l": "2alpha-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] => 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66177", "l": "ATP + H2O + taurochenodeoxycholate 3-sulfate(in) => ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71156", "l": "(E)-caffeoylpyruvate + H2O => (E)-caffeate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047637", "l": "phosphatidylglycerol alanyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24919", "l": "L-homoserine = 2-aminobut-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64010", "l": "CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717841", "l": "holo-FDPS dimer binds NBPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34554", "l": "ATP + cob(II)yrinate c monoamide + H2O + L-glutamine <=> ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36695", "l": "dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid = desmethyldescarbamoylnovobiocin + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.302", "l": "\"L-demethylnoviosyl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981832", "l": "NMUR2 binds neuromedin-S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73295", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine = 7,8-dihydroxy-4'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450387", "l": "HuR binds the CRM1 nuclear export machinery (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72677", "l": "CMP + H(+) => 3',5'-cyclic CMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16210", "l": "Co-precorrin-8X => cob(II)yrinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46301", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782943", "l": "UV-DDB ubiquitinates XPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0010857", "l": "calcium-dependent protein kinase activity", "d": ["Calcium-dependent catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956684", "l": "ITCH polyubiquitinates TP73 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32120", "l": "GDP-valienol + validamine 7-phosphate => GDP + H(+) + validoxylamine A 7'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0015119", "l": "hexose phosphate transmembrane transporter activity", "d": ["Enables the transfer of hexose phosphate from one side of a membrane to the other. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12067", "l": "5-oxopentanoate + H2O + NAD(+) <=> glutarate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74397", "l": "2 (S)-lactate(out) + prostaglandin E1(in) => 2 (S)-lactate(in) + prostaglandin E1(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005585", "l": "MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/SMRT complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69250", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate + D-glucose + H(+) => H2O + sinigrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12626", "l": "(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose => D-glucose + sinapoyl (S)-malate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60380", "l": "L-dehydroascorbate(out) = L-dehydroascorbate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53821", "l": "chenodeoxycholate + NADP(+) => 7-oxolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74716", "l": "Insulin binds the insulin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43102", "l": "2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(44) in tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696482", "l": "CTF1 binds LIFR:JAKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32509", "l": "6-hydroxy-3-isopropenylheptanoate + H(+) => 4-isopropenyl-7-methyloxepan-2-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0009678", "l": "pyrophosphate hydrolysis-driven proton transmembrane transporter activity", "d": ["Enables the transmembrane transport of one proton (H+), driven by the hydrolysis of pyrophosphate, and generating a proton motive force."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53650", "l": "(+)-corvol ether A + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.34", "l": "\"neutrophil collagenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19510", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 2 H(+) + L-erythro-biopterin + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33293", "l": "(E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74594", "l": "(+)-exo-beta-bergamotene + 3 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 5-dehydro-6-demethoxyfumagillol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30928", "l": "2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O => 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1471322", "l": "Beta-defensins are secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48052", "l": "n 3'-phosphoadenylyl sulfate + dermatan = n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)", "d": []}, {"i": "EC:2.8.2.35", "l": "\"dermatan 4-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425861", "l": "Activation of Protein Kinase C novel isoforms (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51609", "l": "(R)-2-hydroxyglutarate + pyruvate => (R)-lactate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17126", "l": "H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine => 2-oxoglutarate + N-(2-aminobutanoyl)glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69102", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804099", "l": "HMGB1 binds LTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47359", "l": "an octanoate ester + H2O <=> an aliphatic alcohol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75719", "l": "CoA-disulfide + H2O = 4'-phosphopantetheinyl-CoA disulfide + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49114", "l": "5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine => phenazine-1-carboxylate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41067", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60784", "l": "2-oxoglutarate + gibberellin A24 + O2 = CO2 + gibberellin A25 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46300", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10654", "l": "a long-chain fatty acid + 2 H(+) + NADH => a long-chain fatty aldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5689111", "l": "PARK2 autoubiquitinates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649735", "l": "Intrinsic nucleotide exchange on RAS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40288", "l": "ATP + CoA + decanedioate => AMP + decanedioyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374663", "l": "DCC interaction with Ezrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28248", "l": "(R)-4-phosphopantoate + ADP + H(+) => (R)-pantoate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46631", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH <=> androst-5-en-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70297", "l": "3-sulfinopyruvate + L-glutamate => 2-oxoglutarate + 3-sulfino-L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399952", "l": "Phosphorylation of LIMK-1 by PAK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76035", "l": "(S)-cis-N-methylstylopine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + protopine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212614", "l": "Glutamine transport from astrocytes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805507", "l": "APAF1 binds AVEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56554", "l": "ADP + H(+) + O-phospho-L-threonyl-[rhodopsin] => ATP + L-threonyl-[rhodopsin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45389", "l": "H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19009", "l": "a 3-acylpyruvate + H2O = a carboxylate + H(+) + pyruvate", "d": []}, {"i": "EC:3.7.1.5", "l": "\"acylpyruvate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.56", "l": "\"gamma-humulene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54299", "l": "GTP + L-tyrosyl-[protein] <=> diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032407", "l": "MutSalpha complex binding", "d": ["Binding to a MutSalpha mismatch repair complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201608", "l": "Caspase-mediated cleavage of alpha adducin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75096", "l": "2 chloride(in) + oxalate(out) => 2 chloride(out) + oxalate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601849", "l": "Defective CYP19A1 does not convert ANDST to E1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43874", "l": "3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate => 3-oxochol-4-en-22-oate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176175", "l": "Stalling of DNA replication fork and RPA binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70568", "l": "H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75918", "l": "H2O + NAD(+) + serinol <=> dihydroxyacetone + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3266557", "l": "Factor I cleaves iC3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59107", "l": "a dolichyl beta-D-glucosyl phosphate + chenodeoxycholate <=> a dolichyl phosphate + beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70328", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+) => 4-methylsulfanyl-2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004719", "l": "protein-L-isoaspartate (D-aspartate) O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44405", "l": "3-demethylubiquinol-7 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23321", "l": "D-tryptophan + malonyl-CoA => CoA + H(+) + N(2)-malonyl-D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16718", "l": "deoxycholate + FAD + H(+) + H2O => cholate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14986", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371422", "l": "ATP hydrolysis by HSP70 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635839", "l": "ULK3:SUFU dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120146", "l": "sulfatide binding", "d": ["Binding to sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside. Sulfatide is a class of sulfoglycolipid, which are glycolipids that contain a sulfate group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27772", "l": "2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71204", "l": "L-homoarginine(in) => L-homoarginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549304", "l": "OCT3 mediates renal clearance of organic cations (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62239", "l": "a cytidine(6-4)cytidine in DNA <=> a cytidine dimer in DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18915", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+) => a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0097364", "l": "stretch-activated, monoatomic cation-selective, calcium channel activity involved in regulation of action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-708349", "l": "Activated NOD2 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120299", "l": "peptide histaminyltransferase activity", "d": ["Catalysis of the reaction: histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl-[protein]."]}, {"i": "RHEA:66564", "l": "histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35136", "l": "L-alanyl-L-glutamate(out) => L-alanyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54935", "l": "(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] <=> (2E,9Z)-hexadecadienoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11468", "l": "(S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine", "d": []}, {"i": "EC:2.6.1.32", "l": "\"valine--3-methyl-2-oxovalerate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56605", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-383190", "l": "HCO3- transport through ion channel (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69705", "l": "beta-D-galactose + N-hexadecanoylsphing-4-enine => beta-D-galactosyl-(1<->1')-N-hexadecanoylsphingosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54807", "l": "2 4-sulfanylbutanoate + NAD(+) <=> 4,4'-disulfanyldibutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27379", "l": "(2R)-2-phosphoglycerate + ADP + H(+) => (R)-glycerate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12260", "l": "ATP + NADH = ADP + H(+) + NADPH", "d": []}, {"i": "EC:2.7.1.86", "l": "\"NADH kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034924", "l": "cis-3,4-phenanthrenedihydrodiol-4-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: cis-3,4-phenanthrenedihydrodiol-4-carboxylate = 3,4-dihydroxyphenanthrene + H+ + 2 e- + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32010", "l": "9alpha-copalyl diphosphate <=> diphosphate + isopimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016905", "l": "myosin heavy chain kinase activity", "d": ["Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74454", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74231", "l": "H2O + L-threonyl-tRNA(Val) = L-threonine + tRNA(Val)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990651", "l": "inositol-1,2,4,5,6-pentakisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,4,6-tetrakisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29275", "l": "L-isoleucine(in) + Na(+)(in) = L-isoleucine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31079", "l": "3-hydroxyisovaleryl-CoA = 3-methyl-(2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3238691", "l": "N-linked glycosylation of WNTs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417077", "l": "Recruitment of telomerase RNP to a telomeric chromosome end (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005148", "l": "prolactin receptor binding", "d": ["Binding to a prolactin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710490", "l": "The GSDME gene promoter is hypermethylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25880", "l": "2 L-dopa + O2 = 2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+)", "d": []}, {"i": "EC:1.13.12.15", "l": "\"3,4-dihydroxyphenylalanine oxidative deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662473", "l": "KGPDC decarboxylates 3-dehydro-L-gulonate to L-xylulose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033265", "l": "choline binding", "d": ["Binding to choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9607342", "l": "Expression of FABP6 regulated by NR1H2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38121", "l": "1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20819", "l": "3alpha-hydroxyglycyrrhetinate + NADP(+) <=> 3-oxoglycyrrhetinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57152", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 = (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.63", "l": "\"peptidyl-lysine (3S)-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75109", "l": "32-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 32-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36967", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61073", "l": "(-)-(R)-19-hydroxytabersonine + acetyl-CoA => (-)-(R)-19-O-acetyltabersonine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41540", "l": "8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.305", "l": "\"8-demethyl-8-alpha-L-rhamnosyl tetracenomycin-C 2'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16451", "l": "CoA + H(+) + N(6')-acetylkanamycin B => acetyl-CoA + kanamycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64047", "l": "(13Z)-docosenoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9634834", "l": "ACHEIs bind ACHE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72974", "l": "5-oxo-L-proline(out) + 2 Na(+)(out) <=> 5-oxo-L-proline(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45146", "l": "acetaldehyde + CO2 + CoA + methanethiol => 3-(methylsulfanyl)acryloyl-CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41272", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950504", "l": "IL27 binds CRLF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20013", "l": "carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate", "d": []}, {"i": "EC:2.1.3.2", "l": "\"aspartate carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69486", "l": "dodecanal + H2O2 => dodecan-1-ol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669859", "l": "Imatinib-resistant KIT mutants do not bind imatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61089", "l": "(S)-eriodictyol + 2-oxoglutarate + O2 => (2R,3R)-dihydroquercetin + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395517", "l": "NADPH transfers electrons to FDXR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43863", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) <=> 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50536", "l": "prostaglandin E2 = H2O + prostaglandin A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731924", "l": "EDNRA binds EDNs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399712", "l": "Activation of Ca permeable AMPA receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75245", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-leucyl-[protein] => acetyl-CoA + N-terminal L-leucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050619", "l": "phytochromobilin:ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: (3Z)-phytochromobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662620", "l": "MT3 binds cadmium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39365", "l": "(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O => (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56997", "l": "aldehydo-D-apiose => apulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44332", "l": "ATP + L-alanine + L-anticapsin = ADP + bacilysin + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.49", "l": "\"L-alanine--L-anticapsin ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2002460", "l": "P4HB binds Collagen chains (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46526", "l": "(5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51781", "l": "4-prenylphlormethylbutanophenone + dimethylallyl diphosphate => deoxyadlupulone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433374", "l": "Processing of SCF isoform 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30920", "l": "A + rhodopin => (3E)-3,4-didehydrorhodopin + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59815", "l": "hexadecanoyl-CoA + N-terminal glycyl-[protein] <=> CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664950", "l": "Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653893", "l": "ATF4, CEBPB, and ATF3 bind the CHAC1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647994", "l": "RAS proteins are depalmitoylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20265", "l": "2-oxoglutarate + L-proline + O2 = cis-3-hydroxy-L-proline + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.28", "l": "\"proline 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987214", "l": "p-STAT3 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30152", "l": "FADH2 + NADP(+) => FAD + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102725", "l": "24-methyldesmosterol reductase activity", "d": ["Catalysis of the reaction: H+ + 24-methyldesmosterol + NADPH = campesterol + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737111", "l": "Protonated weak acid translocates across the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61421", "l": "(S)-8-oxocitronellyl enol => cis-cis-nepetalactol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694793", "l": "Spike protein gets N-glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373738", "l": "Neurofascin interacts with syntenin-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810376", "l": "ING2 binds PI5P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031616", "l": "EGR binds ARC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69349", "l": "S-1-propenyl-L-cysteine sulfoxide => (E)-prop-1-en-1-SO-peroxol + 2-aminoprop-2-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75759", "l": "(9Z,11E)-octadecadienoate + H2O = 10-hydroxy-(11E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75682", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670155", "l": "CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28051", "l": "H2O + NADP(+) => NAD(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27586", "l": "L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine", "d": []}, {"i": "EC:2.6.1.99", "l": "\"L-tryptophan--pyruvate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67676", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35239", "l": "tetracycline(in) = tetracycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018572", "l": "3,5-dichlorocatechol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H+ + 2,4-dichloro-cis,cis-muconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173631", "l": "Activation of C1s (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60287", "l": "N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102307", "l": "erythromycin C 3''-o-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + erythromycin C <=> S-adenosyl-L-homocysteine + erythromycin A + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031517", "l": "red light photoreceptor activity", "d": ["The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660nm. The response may involve a change in conformation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75417", "l": "pseudooxynicotine => H2O + N-methylmyosmine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41981", "l": "3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) => 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004826", "l": "phenylalanine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56903", "l": "globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine <=> globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050021", "l": "L-arabinonolactonase activity", "d": ["Catalysis of the reaction: L-arabinono-1,4-lactone + H2O = L-arabinonate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38805", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine => 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64393", "l": "a dipeptide(out) + H(+)(out) => a dipeptide(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11950", "l": "4-hydroxybenzoate + CoA + H(+) => 4-hydroxybenzoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47410", "l": "(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA => (24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9619756", "l": "NR1H2 binds ABCA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35768", "l": "dihydrosterigmatocystin + S-adenosyl-L-methionine => 8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211239", "l": "Association of DFF40 with chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018644", "l": "toluene 2-monooxygenase activity", "d": ["Catalysis of the reaction: toluene + 1/2 O2 = 2-hydroxytoluene."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015488", "l": "glucuronide:cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucuronide(out) + monovalent cation(out) = glucuronide(in) + monovalent cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1861788", "l": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0003721", "l": "telomerase RNA reverse transcriptase activity", "d": ["Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57064", "l": "D-apionolactone + H2O = D-apionate + H(+)", "d": []}, {"i": "EC:3.1.1.115", "l": "\"D-apionolactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19090", "l": "S-adenosyl-L-methionine + uroporphyrinogen III => H(+) + precorrin-1 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60186", "l": "ADP + D-glucose(in) + H(+) + phosphate => ATP + D-glucose(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205262", "l": "Direct recruitment of PI3K to p-KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21318", "l": "butanoate + H(+) + phorbol 13-butanoate => H2O + phorbol 12,13-dibutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66603", "l": "2 dopamine + O2 <=> 2 dopamine quinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67778", "l": "a 5'-end dephospho-2'-deoxyribonucleoside-DNA + phosphate => a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858270", "l": "HILPDA binds lipid droplets (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17483", "l": "2 cob(II)alamin + NADH => 2 cob(I)alamin + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40660", "l": "1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654224", "l": "Activated FGFR3 binds PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28522", "l": "D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate", "d": []}, {"i": "EC:3.1.3.83", "l": "\"D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17288", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47268", "l": "bacterioruberin = H2O + monoanhydrobacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53797", "l": "deoxycholoyl-CoA + ursodeoxycholate => deoxycholate + ursodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10521", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose => 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75543", "l": "(3R)-3-[(carboxylmethyl)amino]decanoate + H(+) + holo-[ACP] = (2E)-decenoyl-[ACP] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62497", "l": "ATP + H(+) + L-arginine => diphosphate + L-arginyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47467", "l": "(3E,5Z)-tetradecadienoyl-CoA <=> (2E,5Z)-tetradecadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32307", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = H2O + leukotriene A4", "d": []}, {"i": "EC:1.13.11.34", "l": "\"arachidonate 5-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31798", "l": "(+)-(E)-beta-caryophyllene + H2O <=> (+)-caryolan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30430", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-germacrene D + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2465940", "l": "atRAL is reduced to atROL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46109", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2 => (2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408556", "l": "SeO3(2-) combines with GSH to form GSSeSG and GSSG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21840", "l": "N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20389", "l": "(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 = (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74942", "l": "2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + O2 <=> a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388817", "l": "ICOS binds ICOSL/B7-H2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17980", "l": "a long-chain primary fatty alcohol + H2O + 2 NAD(+) <=> a long-chain fatty acid + 3 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43165", "l": "7-cyano-7-deazaguanine + guanosine(15) in tRNA => 7-cyano-7-carbaguanosine(15) in tRNA + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130151", "l": "Dimerization of DAP12 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655266", "l": "Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45465", "l": "eicosanoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z)-eicosenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16283", "l": "ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+) => ATP + dihydrostreptomycin 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796617", "l": "MIB2 binds CFLAR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167633", "l": "Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63900", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) = (2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53616", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-isoafricanol + diphosphate", "d": []}, {"i": "EC:4.2.3.157", "l": "\"(+)-isoafricanol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198958", "l": "KIR2DL2/3 interacting with HLA-C group 1 (Cw4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157100", "l": "NOTCH3 binds JAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58396", "l": "4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35522", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0004767", "l": "sphingomyelin phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995388", "l": "PP2A dephosphorylates BANF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54039", "l": "[mycoredoxin]-L-cysteine + arseno-mycothiol + H(+) <=> [mycoredoxin]-S-mycothiol-L-cysteine + arsenite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850818", "l": "SPINK9 binds KLK5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37898", "l": "H2O + protodioscin <=> 26-deglucoprotodioscin + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195275", "l": "Phosphorylation of APC component of the destruction complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49499", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+) <=> 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30037", "l": "benzene-1,2,4-triol + CO2 + H2O + NAD(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395517", "l": "NADPH transfers electrons to FDXR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683888", "l": "LMCD1 binds GATA6, sequestering it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62840", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16980", "l": "acetoacetate + coenzyme M + NADP(+) <=> 2-oxopropyl-coenzyme M + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690449", "l": "S1PR1 bind S1P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50318", "l": "ethanol + H(+) + octadecanoate => ethyl octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51668", "l": "2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49874", "l": "(+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+) => (+)-dehydrodiconiferyl acid ketone + a quinone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60318", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15407", "l": "[(3R)-hydroxybutanoate](n+1) + CoA => (3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018483", "l": "6-oxohexanoate dehydrogenase activity", "d": ["Catalysis of the reaction: 6-oxohexanoate + NADP+ + H2O = adipate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717841", "l": "holo-FDPS dimer binds NBPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40715", "l": "dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17482", "l": "2 cob(I)alamin + H(+) + NAD(+) => 2 cob(II)alamin + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.30", "l": "\"receptor protein serine/threonine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432371", "l": "CRY is activated by light and binds to phosphorylated nuclear TIM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23782", "l": "(2S,3S)-2-methylcitrate + CoA + H(+) => H2O + oxaloacetate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668395", "l": "CHMP7 binds CC2D1B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59727", "l": "D-maltoheptaono-1,5-lactone + H2O <=> D-maltoheptaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46332", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.22", "l": "\"acyl-lipid omega-6 desaturase (cytochrome b5)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54626", "l": "2-hydroxyoctadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754130", "l": "CDK4 inhibitors bind CDK4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373342", "l": "CX3CR1 binds CX3CL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981832", "l": "NMUR2 binds neuromedin-S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421174", "l": "inosine + orthophosphate <=> hypoxanthine + D-ribose 1-phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3364042", "l": "APC promotes disassembly of beta-catenin transactivation complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427337", "l": "MBD2 binds methylcytosine in chromatin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54431", "l": "4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O <=> ADP-D-ribose + H(+) + L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354073", "l": "Autophosphorylation of PTK2 at Y397 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026544", "l": "Non-enzymatic hydrolysis hydrolyses 13(S),14(S)-epoxy-DHA to 7-epi-MaR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085992", "l": "SUMOylation of DAXX with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14832", "l": "hydrogen sulfide + O-acetyl-L-serine <=> acetate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29321", "l": "ethanolamine + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48647", "l": "prostaglandin H2 <=> (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013006", "l": "RHOA:GTP translocates to the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76071", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19437", "l": "nicotinate + UDP-alpha-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP", "d": []}, {"i": "EC:2.4.1.196", "l": "\"nicotinate glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54555", "l": "1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54181", "l": "a long-chain fatty aldehyde + holo-[ACP] + NAD(+) => a long-chain fatty acyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210439", "l": "glutamate uptake by astrocytes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729307", "l": "Nucleoprotein is SUMOylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57609", "l": "(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) => 3-chlorocatechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-606287", "l": "RSF complex binds the centromere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662608", "l": "MT2A binds cadmium (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37494", "l": "4-coumaroyl-CoA + S-adenosyl-L-methionine <=> CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008411", "l": "4-hydroxybutyrate CoA-transferase activity", "d": ["Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1008200", "l": "NFE2 binds the beta globin locus control region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855375", "l": "PTPN22 dissociates from CSK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683888", "l": "LMCD1 binds GATA6, sequestering it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33585", "l": "2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate => L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50587", "l": "13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) <=> 15-oxoprostaglandin E1 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64321", "l": "(9Z)-hexadecenoyl-CoA + cholesterol => cholesteryl (9Z)-hexadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800315", "l": "MST1 binds MST1R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48100", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.321", "l": "\"type III protein arginine methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703442", "l": "Phosphorylated FLT3 fusions bind GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49474", "l": "H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP => trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62197", "l": "2 Fe(III)-[cytochrome c] + propan-2-ol => acetone + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102223", "l": "4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming)", "d": ["Catalysis of the reaction: 4 H+ + 15-cis-4,4'-diapophytoene + 4 FAD = 4,4'-diapolycopene + 4 FADH2. This reaction consists of three successive dehydrogenations that lead to the introduction of three double bonds into 4,4'-diapophytoene (dehydrosqualene), with 4,4'-diapophytofluene, 4,4'-diapo-zeta-carotene and 4,4'-diapolycopene as intermediates, and 4,4'-diapolycopene as the end product."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14738", "l": "CTP => 3',5'-cyclic CMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102524", "l": "tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + O2 + 7-[(3S)-(3-amino-3-carboxypropyl)]-wyosine37 in tRNAPhe = succinate + carbon dioxide + 7-(2-hydroxy-3-amino-3-carboxypropyl)-wyosine37 in tRNAPhe."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11488", "l": "all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA", "d": []}, {"i": "EC:2.3.1.76", "l": "\"retinol O-fatty-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617829", "l": "Assembly of IFT A complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944214", "l": "Association of procollagen type I (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34397", "l": "L-beta-phenylalanine => L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31194", "l": "(3S)-hydroxydecanoyl-CoA <=> (2E)-decenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46219", "l": "H(+) + NADPH + progesterone <=> 3beta-hydroxypregn-4-ene-20-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41222", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35547", "l": "cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.70", "l": "\"mycocyclosin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75891", "l": "Abortive Initiation After Second Transition (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65304", "l": "2-oxoglutarate + O2 + verruculide A = chrodrimanin T + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57273", "l": "a 2'-deoxyguanosine in DNA + methylglyoxal => an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46627", "l": "a D-5-monosubstituted hydantoin <=> a L-5-monosubstituted hydantoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4411383", "l": "NLK phosphorylates TCF/LEF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54233", "l": "1,2-dioctanoyl-sn-glycerol + CDP-choline => 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40177", "l": "(2E)-octenoyl-CoA + H2O2 => O2 + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11926", "l": "globoside Gb3Cer (d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708275", "l": "PDE4A binds PDE4A inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14485", "l": "(2E,6E)-farnesyl diphosphate + H2O = 10-epi-juneol + diphosphate", "d": []}, {"i": "EC:4.2.3.172", "l": "\"10-epi-juneol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31158", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) <=> (4S)-4-hydroxy-L-glutamate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.098124162625822", "identifiers": [{"i": "GO:0044736", "l": "acid-sensing ion channel activity", "d": ["Enables the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when an extracellular proton has been bound by the channel complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015314", "l": "aminotriazole:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29565", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate => ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19717", "l": "H(+) + L-phenylalanine = 2-phenylethylamine + CO2", "d": []}, {"i": "EC:4.1.1.53", "l": "\"phenylalanine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050471", "l": "uracilylalanine synthase activity", "d": ["Catalysis of the reaction: O3-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10431", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68268", "l": "dUMP + formaldehyde + H(+) + NADPH = dTMP + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66062", "l": "H2O + kynurenate + L-2-aminohexanoate => 2-oxohexanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40328", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50710", "l": "(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196773", "l": "COASY phosphorylates DP-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56786", "l": "(6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-606326", "l": "HJURP:CENPA complex localizes to the centromere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168849", "l": "tBID binds to inactive BAX protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43196", "l": "adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334179", "l": "DNMT3A:DNMT3L binds chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18096", "l": "5,6-dihydrouracil + NADP(+) <=> H(+) + NADPH + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879358", "l": "AGER-1,2,3 bind AGEs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000310", "l": "xanthine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63938", "l": "3 a ubiquinol + protoporphyrin IX => 3 a ubiquinone + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018825", "l": "RHOT2 GEFs activate RHOT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0005338", "l": "nucleotide-sugar transmembrane transporter activity", "d": ["Enables the transfer of a nucleotide-sugar from one side of a membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47639", "l": "H2O + L-arginine + NADP(+) <=> 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42751", "l": "cytidine(967) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48158", "l": "ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate => ganglioside GQ1b (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21974", "l": "precorrin-2 + S-adenosyl-L-homocysteine => precorrin-1 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033980", "l": "phosphonopyruvate decarboxylase activity", "d": ["Catalysis of the reaction: 3-phosphonopyruvate + 2 H+ = CO2 + phosphonoacetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015667", "l": "site-specific DNA-methyltransferase (cytosine-N4-specific) activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12758", "l": "dihydrozeatin + NADP(+) => H(+) + NADPH + zeatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700266", "l": "CFTR F508del binds CFTR correctors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016524", "l": "latrotoxin receptor activity", "d": ["Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62656", "l": "2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate = 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58267", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol <=> an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10371", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15256", "l": "cis-aconitate + H(+) <=> CO2 + itaconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16240", "l": "[protein]-peptidylproline (omega=180) <=> [protein]-peptidylproline (omega=0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203774", "l": "Interaction of Csk with PAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67787", "l": "2 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol <=> 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0030553", "l": "cGMP binding", "d": ["Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67988", "l": "N-acetyl-L-glutamine = N-acetyl-D-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9727349", "l": "XDH dehydrogenates xanthine to form urate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24087", "l": "all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72853", "l": "ADP(in) + AMP(out) => ADP(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0015182", "l": "L-asparagine transmembrane transporter activity", "d": ["Enables the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56657", "l": "12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110011", "l": "Binding of Grb10 to the insulin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13138", "l": "cycloartenol + S-adenosyl-L-methionine => cyclolaudenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48770", "l": "ADP + D-erythrulose 4-phosphate + H(+) => ATP + D-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39493", "l": "(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+) => (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47309", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50335", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.53", "l": "\"methylenetetrahydrofolate reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42234", "l": "1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791235", "l": "GADD45A binds AURKA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981621", "l": "Neuroglobin:oxygen dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23860", "l": "acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA", "d": []}, {"i": "EC:2.3.1.175", "l": "\"deacetylcephalosporin-C acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33405", "l": "diphosphate + L-threonyl-5'-AMP => ATP + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68844", "l": "(2Z,6E)-farnesyl diphosphate = (Z)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696271", "l": "RND1 binds effectors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62990", "l": "dodecanoate + NH4(+) => dodecanamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46170", "l": "AMP + diphosphate + pentanoyl-CoA => ATP + CoA + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39167", "l": "H(+) + malonyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47601", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate => CMP + ganglioside GM4 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432897", "l": "ILK interacts with beta-1 integrin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396124", "l": "AGRN binds Laminins with gamma-1 subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008403", "l": "25-hydroxycholecalciferol-24-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-166015", "l": "Association of LBP with LPS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30971", "l": "7,7',9,9'-tetra-cis-lycopene = all-trans-lycopene", "d": []}, {"i": "EC:5.2.1.13", "l": "\"prolycopene isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42093", "l": "all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31524", "l": "2-oxoglutarate + 2 H(+) + O2 => 3 CO2 + ethene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25503", "l": "(2E)-geranyl diphosphate <=> diphosphate + terpinolene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33746", "l": "an N-acylsphing-4-enine 1-phosphate + H2O <=> an N-acylsphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39185", "l": "(3R)-hydroxydocosanoyl-CoA + NADP(+) => 3-oxodocosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44001", "l": "2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 => 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62973", "l": "acetyl-CoA + 2 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + orsellinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14216", "l": "ATP + beta-D-fructose 1-phosphate <=> ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16443", "l": "L-glutamyl-[protein] + NH4(+) => H2O + L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662747", "l": "iRHOM2 transports ADAM17 from ER to the Golgi-network (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689317", "l": "Formation of the pre-incision complex in GG-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627078", "l": "XIAP binds CASP9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.32", "l": "\"glucomannan 4-beta-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44717", "l": "A + all-trans-4,4'-diapolycopen-4-al + H2O => AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866277", "l": "AP-2 directly binds some endocytic cargo (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73886", "l": "guanidine(out) <=> guanidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28326", "l": "H2O + wogonin 7-O-beta-D-glucuronate = D-glucuronate + H(+) + wogonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15778", "l": "1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O => 1-guanidino-1-deoxy-scyllo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192123", "l": "CYP27A1 27-hydroxylates CHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665998", "l": "MKL1 binds SRF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16063", "l": "choline + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17374", "l": "all-trans-antheraxanthin => all-trans-capsanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50182", "l": "N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678854", "l": "S1PR1 binds S1PR1 agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729730", "l": "SARS-CoV-2 nsp3 cleaves IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50925", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58661", "l": "a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-methionine => a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67011", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941312", "l": "TUT4,TUT7 oligouridylate mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42217", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) => 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50411", "l": "1-(2-aminophenyl)decane-1,3-dione <=> 2-heptyl-4(1H)-quinolone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432188", "l": "AVP:AVPR2 Complex binds inactive heterotrimeric G(s) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-417842", "l": "P2Y10 receptor can bind to LPA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51785", "l": "4-prenylphlorisovalerophenone + dimethylallyl diphosphate => deoxyhumulone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0038064", "l": "collagen receptor activity", "d": ["Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36405", "l": "a fatty acid + cholesterol + H(+) => a cholesterol ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75639", "l": "(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate = (12S,13R)-epoxy-(10R)-hydroxy-(8E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3204311", "l": "AOX1 oxidises PXL to PDXate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64473", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine => (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784598", "l": "NPPA(124-151) binds NPR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19514", "l": "carbamoyl phosphate + L-ornithine => H(+) + L-citrulline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602484", "l": "Activation of proMMP11 by FURIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661419", "l": "ALB binds extracellular heme (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684140", "l": "ATM phosphorylates RBBP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851933", "l": "MET phosphorylates GAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46572", "l": "2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59493", "l": "(2E)-geranyl diphosphate + L-tryptophyl-[protein] => (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433501", "l": "Interaction of other adapter proteins with p-KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42267", "l": "H(+) + malonyl-[ACP] + octanoyl-CoA <=> 3-oxodecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16961", "l": "epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine", "d": []}, {"i": "EC:4.3.2.8", "l": "\"gamma-glutamylamine cyclotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34009", "l": "5-dehydroepisterol + H(+) + S-adenosyl-L-homocysteine => 7-dehydrodesmosterol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212642", "l": "L-Glutamine transport into neurons (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045482", "l": "trichodiene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + trichodiene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63786", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061664", "l": "Pup ligase activity", "d": ["Catalysis of the transfer of Pup to a substrate protein via the reaction X-Pup + S = X + S-Pup, where X is either an E2 or E3 enzyme, the X-Pup linkage is a thioester bond, and the S-Pup linkage is an isopeptide bond between the C-terminal amino acid of Pup and the epsilon-amino group of lysine residues in the substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74433", "l": "1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in) => 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63168", "l": "fumarate + L-cysteine = S-(2-succino)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75996", "l": "3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) => 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0051082", "l": "unfolded protein binding", "d": ["Binding to an unfolded protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44514", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13672", "l": "5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) <=> 3-hydroxy-2-methylpyridine-5-carboxylate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102210", "l": "rhamnogalacturonan endolyase activity", "d": ["Catalysis of the reaction: H2O + a rhamnogalacturonan type I <=> [rhamnogalacturonan I oligosaccharide]-alpha-L-rhamnose + 4-deoxy-4,5-unsaturated D-galactopyranosyluronate-[rhamnogalacturonan I oligosaccharide]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950721", "l": "Expression of Programmed cell death protein 4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388900", "l": "Neurotensin receptors can bind neurotensins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693575", "l": "DNA-PKcs autophosphorylates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68994", "l": "3-amino-2,4-dihydroxybenzoate + H2O + NADP(+) => 3-amino-4-hydroxybenzoate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419426", "l": "Cannabinoid receptors can bind cannabinoids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392530", "l": "p-S400-Cot phosphorylates NIK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28231", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3700992", "l": "TP53 stimulates MDM2 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59713", "l": "D-maltotetraono-1,5-lactone + H2O => D-maltotetraonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75498", "l": "n H(+)(out) + pregnenolone sulfate(out) <=> n H(+)(in) + pregnenolone sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57244", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP = dGTP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37233", "l": "L-alanine + NH4(+) => H2O + L-alaninamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204169", "l": "PDP dephosphorylates p-lipo-PDH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390649", "l": "CHRM1,3,5 bind acetylcholine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188025", "l": "Flagellin binds to TLR5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19403", "l": "formaldehyde + H(+) + NADH => methanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69991", "l": "3-dehydro-6-deoxoteasterone + NADP(+) = (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38076", "l": "2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34428", "l": "(-)-lariciresinol + NADP(+) => (-)-pinoresinol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102981", "l": "4-hydroxy-5-methyl-2-propyl-3(2H)-furanone oxidoreductase activity", "d": ["Catalysis of the reaction: 4-hydroxy-5-methyl-2-propyl-3(2H)-furanone + NADP <=> (2E)-4-hydroxy-5-methyl-2-propylidene-3(2H)-furanone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793472", "l": "RIPK3 binds p-S9-PRKN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382056", "l": "Crk binds to the active PDGF receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32064", "l": "8-oxo-dGDP + H2O => 8-oxo-dGMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13301", "l": "a 1,2-diacyl-sn-glycerol + a sterol = a 1-acyl-sn-glycerol + a sterol ester", "d": []}, {"i": "EC:2.3.1.73", "l": "\"diacylglycerol--sterol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39377", "l": "(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295613", "l": "SPRY2 binds GRB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684006", "l": "KPNA2 translocates NBN to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011543", "l": "DCA binds PDK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36927", "l": "(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.4", "l": "\"chymosin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28896", "l": "cadaverine(in) + L-lysine(out) => cadaverine(out) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005304", "l": "L-valine transmembrane transporter activity", "d": ["Enables the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663120", "l": "p-BMAL1:p-CLOCK,NPAS2 binds CRY1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58222", "l": "H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide => L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047108", "l": "(R)-3-hydroxyacid-ester dehydrogenase activity", "d": ["Catalysis of the reaction: ethyl (R)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730899", "l": "Oligomerization of BCL10 and MALT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964550", "l": "The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds E2F1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56764", "l": "12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 = 12-epi-fischerindole G + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37191", "l": "2',3'-cyclophospho-AMP + H2O = adenosine 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047407", "l": "ADP-ribosyl-[dinitrogen reductase] hydrolase activity", "d": ["Catalysis of the reaction: ADP-ribosyl-[dinitrogen reductase] = adenosine diphosphate ribose + [dinitrogen reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855648", "l": "SALM3 binds LAR-RPTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45798", "l": "acetoacetyl-CoA + H(+) + NADPH => (3R)-3-hydroxybutanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204169", "l": "PDP dephosphorylates p-lipo-PDH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33637", "l": "AMP + diphosphate + docosanoyl-CoA => ATP + CoA + docosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14465", "l": "H2O + L-histidinol phosphate = L-histidinol + phosphate", "d": []}, {"i": "EC:3.1.3.15", "l": "\"histidinol-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31632", "l": "2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate => phosphate + pseudaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626938", "l": "Beta-catenin binds SOX proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187332", "l": "Cytosolic CMs translocate to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688459", "l": "RIPK3 binds HSP90:CDC37 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50112", "l": "octadecanoyl-CoA + taurine = CoA + H(+) + N-octadecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610720", "l": "PKA phosphorylates GLI3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20399", "l": "H(+) + L,L-cystathionine + succinate => L-cysteine + O-succinyl-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69127", "l": "Formation of the Flap Intermediate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944215", "l": "Association of procollagen type XX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63400", "l": "Fe(II)-hydroxyheme i = Fe(II)-heme a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350147", "l": "VD3 translocates from extracellular region to ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29235", "l": "a menaquinone + H(+) + NADH = a menaquinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48006", "l": "3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O => 1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627089", "l": "CASP9 is phosphorylated at T412 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0005295", "l": "neutral L-amino acid:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) = neutral L-amino acid(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57116", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17418", "l": "ATP + N-acetyl-D-glucosamine => ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097372", "l": "NAD-dependent histone H3K18 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48130", "l": "(2E,6E)-farnesyl phosphate + H(+) + phosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30123", "l": "H2O + tetradecanoyl-[ACP] = H(+) + holo-[ACP] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69836", "l": "campesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420688", "l": "GABAB heterodimeric receptor binds GABA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25666", "l": "(2E)-geranyl diphosphate = beta-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75720", "l": "CoA-disulfide + H2O => 4'-phosphopantetheinyl-CoA disulfide + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.78", "l": "\"granzyme A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166175", "l": "TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5334827", "l": "SUMO-CRABP2 binds atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849906", "l": "SALM1 binds NMDA receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53391", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate <=> 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73098", "l": "AMP(out) + CoA(in) <=> AMP(in) + CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.40", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6785594", "l": "FANCD2 binds FANCI (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37756", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40063", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O = 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55768", "l": "all-trans-retinoate + UDP-alpha-D-glucuronate = all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425861", "l": "Activation of Protein Kinase C novel isoforms (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24866", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 => 4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39277", "l": "(15Z)-tetracosenoyl-CoA + NADP(+) => (2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25520", "l": "an acyl-CoA + pseudotropine = CoA + H(+) + O-acylpseudotropine", "d": []}, {"i": "EC:2.3.1.186", "l": "\"pseudotropine acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944227", "l": "Association of procollagen type XXII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20978", "l": "an aldehyde + H(+) + H2O2 + nitrite => a primary nitroalkane + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390011", "l": "HPO dimer binds to SAV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17419", "l": "ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate => ATP + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31387", "l": "(S)-2,3-epoxysqualene = alpha-amyrin", "d": []}, {"i": "EC:5.4.99.40", "l": "\"alpha-amyrin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29026", "l": "H(+)(in) + L-fucose(in) <=> H(+)(out) + L-fucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15094", "l": "2-oxoglutarate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12169", "l": "allyl alcohol + NADP(+) => acrolein + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50198", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114256", "l": "CYCS:APAF1 binds procaspase-9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62730", "l": "(+)-malbrancheamide D + FADH2 => (+)-malbrancheamide B + bromide + FAD + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483209", "l": "PG is converted to BMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56769", "l": "2 AH2 + all-trans-zeaxanthin + 2 O2 => 2 A + all-trans-adonixanthin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351208", "l": "Spermidine  => N-acetylated spermidine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047203", "l": "13-hydroxylupinine O-tigloyltransferase activity", "d": ["Catalysis of the reaction: 13-hydroxylupanine + 2-methylcrotonoyl-CoA = 13-(2-methylcrotonoyloxy)lupanine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693356", "l": "CEMIP hydrolyses HA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74258", "l": "XDH oxidizes xanthine to form urate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849463", "l": "PTK6 phosphorylates SFPQ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37413", "l": "aklaviketone + 2 H(+) + NADPH => aklavinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609860", "l": "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70767", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23298", "l": "N-acetyl-D-mannosamine + pyruvate => aceneuramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928632", "l": "ITSN1 exchanges GTP for GDP on CDC42, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62823", "l": "1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15312", "l": "(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15935", "l": "(S)-lactaldehyde + H(+) + NADH => (S)-propane-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.2", "l": "\"papain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.18", "l": "\"[myosin light-chain] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610388", "l": "HCMV translocates from the endosome lumen to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27639", "l": "phosphate + xanthosine => alpha-D-ribose 1-phosphate + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389159", "l": "CSF1R trans-autophosphorylates on multiple tyrosine and serine residues (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31182", "l": "(3S)-3-hydroxydodecanoyl-CoA + NAD(+) <=> 3-oxododecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46195", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58433", "l": "(E)-4-oxonon-2-en-1-ol + NADP(+) => (E)-4-oxonon-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31621", "l": "dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029468", "l": "Conversion of PA into DAG by PAP-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62266", "l": "hydrogencarbonate(in) + selenite(in) + Zn(2+)(in) => hydrogencarbonate(out) + selenite(out) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64099", "l": "3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] <=> 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45832", "l": "(3R)-3-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433418", "l": "Phosphorylation of JAK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047903", "l": "fructose 5-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-fructose + NADP+ = 5-dehydro-D-fructose + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18883", "l": "ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate => ATP + histamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29355", "l": "dUMP + H2O = 2'-deoxyuridine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28920", "l": "4-aminobutanoate(in) + L-glutamate(out) => 4-aminobutanoate(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052793", "l": "pectin acetylesterase activity", "d": ["Catalysis of the reaction: pectin + H2O = pectate + acetate. This reaction is the hydrolysis of acetyl esters of pectin, producing pectate, partially esterified pectin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45400", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.42", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033714", "l": "secondary-alcohol oxidase activity", "d": ["Catalysis of the reaction: secondary alcohol + O2 = H2O2 + ketone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35897", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26165", "l": "AH2 + echinenone + O2 => 4'-hydroxyechinenone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43808", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28835", "l": "citrate(out) + succinate(in) = citrate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70620", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658195", "l": "Defective SLC5A5 does not cotransport Na+ with I- from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43786", "l": "H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine => adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60930", "l": "17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55605", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base => a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19569", "l": "5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.61", "l": "\"tRNA 5-(aminomethyl)-2-thiouridylate-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003711", "l": "transcription elongation factor activity", "d": ["A molecular function that stimulates the elongation properties of the RNA polymerase during the elongation phase of transcription. A subclass of transcription elongation factors enable the transition from transcription initiation to elongation, while another class rescue stalled RNA polymerases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35407", "l": "H2O + medicarpin = 4'-methoxyisoflavan-2',4,7-triol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047937", "l": "glucose-1-phosphate phosphodismutase activity", "d": ["Catalysis of the reaction: 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28282", "l": "(S)-beta-bisabolene = (S)-beta-macrocarpene", "d": []}, {"i": "EC:5.5.1.17", "l": "\"(S)-beta-macrocarpene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508292", "l": "SYK binds IL2RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36102", "l": "benzoate + S-adenosyl-L-methionine <=> methyl benzoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59463", "l": "hexadecan-1-ol + NADP(+) <=> H(+) + hexadecanal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.1", "l": "\"nitrate reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68611", "l": "Formation of ORC(1-5) complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23876", "l": "protoaphin aglucone = H2O + xanthoaphin", "d": []}, {"i": "EC:4.2.1.73", "l": "\"protoaphin-aglucone dehydratase (cyclizing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40889", "l": "H(+) + octadecanoate + sn-glycerol 3-phosphocholine => 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193665", "l": "MYD88 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-205136", "l": "GTP-bound RAC contributes to JNK activation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.23", "l": "\"acylglycerol lipase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392852", "l": "Activated prostacyclin receptor binds G-protein Gs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868236", "l": "BAR domain proteins recruit dynamin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420233", "l": "VIP receptors bind VIP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786190", "l": "CMBL hydrolyses OM to OLMS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38123", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol = 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660757", "l": "Ub-SNCA dissociates from the conjugating enzyme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31106", "l": "7,8-dihydrofolate + NADP(+) <=> folate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29200", "l": "(S)-dihydroorotate + menaquinone-8 => menaquinol-8 + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62607", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54193", "l": "L-lysyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450488", "l": "BRF1 Complex recruits RNA degradation activities (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18443", "l": "5,6-dihydroxyindole + CO2 => D-dopachrome + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39633", "l": "(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+) => (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007647", "l": "E2F6 binds CBX5 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866941", "l": "MID1IP1 binds THRSP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19745", "l": "3,3',5-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-thyroxine", "d": []}, {"i": "EC:1.21.99.4", "l": "\"thyroxine 5'-deiodinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983142", "l": "Formation of peptide loading complex (PLC) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53981", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57585", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32505", "l": "(6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => linalool + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27321", "l": "3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65886", "l": "H2O + L-glutamate + xanthurenate => 2-oxoglutarate + 3-hydroxy-L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047780", "l": "citrate dehydratase activity", "d": ["Catalysis of the reaction: citrate = cis-aconitate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977371", "l": "Factor I inactivates Factor H-boundC3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953111", "l": "E2F6 binds TFDP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35381", "l": "(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA => (6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985594", "l": "MYO9B inactivates RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53379", "l": "5,6-dihydrouridine(16) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(16) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16476", "l": "cyclohexane-1,3-dione + H2O <=> 5-oxohexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14423", "l": "4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine => H2O + N(2)-benzoyl-D-arginine-4-nitroanilide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27831", "l": "neryl diphosphate => beta-phellandrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660980", "l": "p-S276-RELA binds RELB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38449", "l": "4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose => 4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9674095", "l": "PDGFRs bind type II TKI (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196753", "l": "2xPPCS ligates PPanK with Cys (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32820", "l": "chromate(in) => chromate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14707", "l": "CoA-disulfide + H(+) + NADPH => 2 CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24325", "l": "6-oxocineole + H(+) + NADPH + O2 => 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850945", "l": "Casein kinase II phosphorylates PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46060", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15613", "l": "NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin", "d": []}, {"i": "EC:1.3.1.76", "l": "\"precorrin-2 dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874718", "l": "TTPA binds alpha-TOH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61642", "l": "benzoyl-CoA + CO2 => H(+) + isophthalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72560", "l": "estrone 3-sulfate(out) + pentanoate(in) => estrone 3-sulfate(in) + pentanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39954", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35674", "l": "(S)-5'-oxoaverantin + H(+) <=> (1'S,5'S)-averufin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24798", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O => (S)-2-amino-6-oxoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451309", "l": "Edited Kainate Receptor binds glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106245", "l": "L-serine-phosphatidylethanolamine phosphatidyltransferase activity", "d": ["Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine <=> L-1-phosphatidylserine + ethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60627", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O <=> 2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64836", "l": "2-phenylethanol + acetyl-CoA = CoA + phenethyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102670", "l": "2,7,4'-trihydroxyisoflavanone-4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: 2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine <=> H+ + 2,7-dihydroxy-4'-methoxyisoflavanone + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17484", "l": "2 cob(I)alamin + H(+) + NAD(+) <=> 2 cob(II)alamin + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4724330", "l": "Defective ALG8 does not add glucose to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110215", "l": "Cleavage of uracil by UNG glycosylase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165162", "l": "Phosphorylation of TSC2 by PKB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37066", "l": "2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200646", "l": "Cytosolic folate export across the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54770", "l": "[LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24298", "l": "H(+) + N-carbamoyl-L-aspartate => (S)-dihydroorotate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21606", "l": "2-phenylacetaldehyde => styrene oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668978", "l": "MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785607", "l": "FANCM binds FAAP24 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940959", "l": "Neurolysin degrades neurotensin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050315", "l": "synephrine dehydratase activity", "d": ["Catalysis of the reaction: synephrine = (4-hydroxyphenyl)acetaldehyde + methylammonium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31861", "l": "glutinol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71132", "l": "H(+)(in) + L-asparagine(out) + Na(+)(out) => H(+)(out) + L-asparagine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19680", "l": "9'-cis-neoxanthin + O2 <=> (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43795", "l": "adenosine(645) in 25S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47999", "l": "1,6-dihydro-beta-NAD + H(+) + O2 <=> H2O2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61923", "l": "(2R,4S)-ketoconazole(in) + ATP + H2O <=> (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42519", "l": "H2O + L-gulono-1,4-lactone <=> H(+) + L-gulonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62438", "l": "2-dehydro-3-deoxy-L-arabinonate + H2O => L-lyxonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73013", "l": "L-leucine(out) => L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55363", "l": "11-cis-retinol <=> 9-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141437", "l": "Formation of the MCC complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28299", "l": "(2E,6E)-farnesyl diphosphate => (E)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210273", "l": "Interaction of DAP12 and NKp44 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44232", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0097177", "l": "mitochondrial ribosome binding", "d": ["Binding to a mitochondrial ribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48890", "l": "(13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67299", "l": "(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 <=> (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38200", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429101", "l": "HMIT co-transports myo-inositol with a proton (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018768", "l": "RHOU auto-activates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41353", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.166077096831089", "identifiers": [{"i": "GO:0032452", "l": "histone demethylase activity", "d": ["Catalysis of the removal of a methyl group from a histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53067", "l": "2-methoxyestrone + UDP-alpha-D-glucuronate <=> 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69142", "l": "acrolein + putrescine => N-(4-aminobutyl)-3-aminopropanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45084", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.130", "l": "\"laurate 7-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66156", "l": "butanoyl-CoA + tyramine = CoA + H(+) + N-butanoyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25435", "l": "beta-D-ribopyranose <=> beta-D-ribofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19875", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate => dehydroepiandrosterone 3-sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15034", "l": "O2 + pyridoxine => H2O2 + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55549", "l": "N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72230", "l": "chloride(out) + 2 Na(+)(out) + sarcosine(out) <=> chloride(in) + 2 Na(+)(in) + sarcosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021357", "l": "PRKCI phosphorylates ELF3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432067", "l": "Aquaporin-4 passively transports water out of cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9659820", "l": "RB1 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18587", "l": "dihydroxyacetone phosphate => D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69239", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate <=> 4-hydroxybutylnitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204500", "l": "CyP60 chaperones Basigin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956684", "l": "ITCH polyubiquitinates TP73 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389354", "l": "Activation of Vav1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876446", "l": "p-ULK1 phosphorylates DENND3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18657", "l": "(R)-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015446", "l": "ATPase-coupled arsenite transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810392", "l": "TMEM55B translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873921", "l": "Binding of STAT1 to p-IFNGR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72046", "l": "L-glutamate(in) + orotate(out) <=> L-glutamate(out) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74723", "l": "Endosome acidification (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38833", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013109", "l": "RHOC GEFs activate RHOC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043910", "l": "ATP:coenzyme F420 adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + factor gamma-F420-2 + H+ = coenzyme F390-A + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48635", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799350", "l": "Exocytosis of specific granule membrane proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27437", "l": "2 glutathione amide + H2O2 = glutathione amide disulfide + 2 H2O", "d": []}, {"i": "EC:1.11.1.17", "l": "\"glutathione amide-dependent peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36399", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) = H(+) + NADPH + zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430308", "l": "PARVB interacts with Alpha-actinin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445072", "l": "Interaction of PAK1 with Rac1-GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445714", "l": "Aquaporin-3 passively transports water out of cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58825", "l": "4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380930", "l": "Phosphorylated AMPK binds AMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60279", "l": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23360", "l": "L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696605", "l": "USP12, USP26 deubiquitinate AR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57522", "l": "3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39395", "l": "3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005132", "l": "type I interferon receptor binding", "d": ["Binding to an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30959", "l": "9,9'-di-cis-zeta-carotene + a quinone = 7,9,9'-tri-cis-neurosporene + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420131", "l": "The PACAP receptor binds PACAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28798", "l": "2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807872", "l": "Active ARF recruits coatomer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51080", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390673", "l": "CHRM2,4 bind acetylcholine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033723", "l": "fluoroacetaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853762", "l": "RET dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57579", "l": "7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53664", "l": "(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+) = H(+) + 2 H2O + pyridinestrone carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.18", "l": "\"calcidiol 1-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38424", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874205", "l": "MBTPS1 (S1P) cleaves CREB3L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46562", "l": "5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419277", "l": "GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18355", "l": "ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate => ATP + H2O + K(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371582", "l": "HSBP1 binds HSF1 trimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28042", "l": "CoA + NAD(+) + pyruvate = acetyl-CoA + CO2 + NADH", "d": []}, {"i": "EC:1.2.1.104", "l": "\"pyruvate dehydrogenase system\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50103", "l": "dodecanoyl-CoA + taurine <=> CoA + H(+) + N-dodecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22262", "l": "H(+) + triacetate => H2O + triacetate lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59398", "l": "D-leucine => L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66146", "l": "CoA + H(+) + melatonin => 5-methoxytryptamine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32305", "l": "(2R,3S)-homoisocitrate => (2R)-homocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60147", "l": "ATP + L-glutamate + L-glutamyl-[protein] <=> ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53892", "l": "an S-prenyl-L-cysteine + H2O + O2 = a prenal + H2O2 + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871260", "l": "YAP1 binds TEAD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912379", "l": "Transport of fringe-modified NOTCH to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31703", "l": "2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18801", "l": "(cis-prenyl)n-diphosphate + isopentenyl diphosphate = (cis-prenyl)(n+1)-diphosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.20", "l": "\"rubber cis-polyprenylcistransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17257", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vinorine = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine", "d": []}, {"i": "EC:1.14.14.104", "l": "\"vinorine hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22376", "l": "uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA", "d": []}, {"i": "EC:5.4.99.12", "l": "\"tRNA pseudouridine(38-40) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940554", "l": "MMP2 cleaves OPTC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030793", "l": "3'-demethylstaurosporine O-methyltransferase activity", "d": ["Catalysis of the reaction: 3'-demethylstaurosporine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + H+ + staurosporine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57044", "l": "D-apionate + NAD(+) = 3-oxoisoapionate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.421", "l": "\"D-apionate oxidoisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29537", "l": "a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13945", "l": "(S)-mandelate = (R)-mandelate", "d": []}, {"i": "EC:5.1.2.2", "l": "\"mandelate racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168297", "l": "Recognition of the Nuclear Localization Signal (NLS) by a Karyopherin Alpha Family Protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13608", "l": "2 L-ascorbate + O2 <=> 2 H2O + 2 L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32755", "l": "(2S)-naringenin + 2-oxoglutarate + O2 = apigenin + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247847", "l": "WLS is endocytosed to the early endosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63532", "l": "angiotensin I + H2O = angiotensin-(1-9) + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23169", "l": "coformycin + NADP(+) => 8-oxocoformycin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4647594", "l": "SAHF formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55079", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) <=> 3-methylsulfanylpropanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16874", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA => (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605632", "l": "Both hexosaminidase A and B can cleave GalNAc from globoside (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947531", "l": "Molybdenum ion transfer onto molybdopterin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58542", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-dodecanoylglycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112429", "l": "Formation of FACT complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45972", "l": "3-oxochol-4-en-22-oate + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40227", "l": "3'-phosphoadenylyl sulfate + desulfo-A47934 = A47934 + adenosine 3',5'-bisphosphate + H(+)", "d": []}, {"i": "EC:2.8.2.36", "l": "\"desulfo-A47934 sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48562", "l": "D-ribose 5-phosphate + N(6)-dimethylallyladenine => H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39463", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA = (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44094", "l": "AMP + diphosphate + nonadecanoyl-CoA => ATP + CoA + nonadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140337", "l": "diacylglyceride transfer activity", "d": ["Directly binding to diacylglyceride and delivering it either to an acceptor molecule or to a specific location."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37502", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430096", "l": "GP1b-IX-V binds filamin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004078", "l": "biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming))."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.15", "l": "\"renin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046987", "l": "N-acetyllactosamine beta-1,3-glucuronosyltransferase activity", "d": ["Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-D-glucuronic acid to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56692", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate", "d": []}, {"i": "EC:1.14.20.10", "l": "\"tyrosine isonitrile desaturase/decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71444", "l": "3-O-methyl-L-dopa(out) + L-phenylalanine(in) => 3-O-methyl-L-dopa(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39717", "l": "(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O => (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225960", "l": "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23855", "l": "catechol + O2 <=> cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23038", "l": "2 5'-dehydroinosine + 2 H2O => 2 inosine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74512", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B => aspoquinolone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209944", "l": "25(OH)D binds GC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665871", "l": "ADRM1 binds 26S proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37189", "l": "1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38177", "l": "all-trans-retinyl hexadecanoate + CoA => all-trans-retinol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52945", "l": "cholate + UDP-alpha-D-glucuronate => choloyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58419", "l": "(E)-4-hydroxynon-2-en-1-ol + NADP(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754974", "l": "ADK phosphorylates RBV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944247", "l": "Association of procollagen type VI (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015375", "l": "glycine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047227", "l": "indolylacetyl-myo-inositol galactosyltransferase activity", "d": ["Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20068", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 <=> 3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196753", "l": "2xPPCS ligates PPanK with Cys (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71359", "l": "17beta-estradiol 17-sulfate(out) + 2 Na(+)(out) = 17beta-estradiol 17-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56538", "l": "1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA => (12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53002", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP => 17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103059", "l": "UDP-L-rhamnose:kaempferol 3-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol oxoanion + UDP-L-rhamnose <=> H+ + kaempferol-3-rhamnoside + UDP(3-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24114", "l": "glutathione disulfide + H2O2 => 2 glutathione + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24590", "l": "ADP + D-arabinose 5-phosphate + H(+) => ATP + D-arabinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15501", "l": "2 L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + L-glutamine + NADPH", "d": []}, {"i": "EC:1.4.1.13", "l": "\"glutamate synthase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47395", "l": "H2O + hexadecanoate ester <=> an aliphatic alcohol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58604", "l": "FAD + 2 H(+) + NADH + O2 = FADH2-C4alpha-hydroperoxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0050485", "l": "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is disulfide."]}, {"i": "EC:1.21.4.-", "l": "\"With a disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2106615", "l": "Removal of siRNA passenger strand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296045", "l": "Activation of Potassium transport channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6813740", "l": "GDE1 hydrolyzes GroPIns (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009488", "l": "IL34 binds CSF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70458", "l": "(6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70048", "l": "2-oxoadipate + L-kynurenine => H2O + kynurenate + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41302", "l": "H2O + N-(9Z-octadecenoyl)-sphing-4-enine <=> (9Z)-octadecenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38100", "l": "a ribonucleoside 5'-triphosphate + phytyl phosphate => a ribonucleoside 5'-diphosphate + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25003", "l": "H(+) + N,N-dihydroxy-L-phenylalanine <=> (E)-phenylacetaldehyde oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30966", "l": "7,9,9'-tri-cis-neurosporene + a quinone <=> 7,7',9,9'-tetra-cis-lycopene + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686587", "l": "ABL1 phosphorylates RAD52 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74964", "l": "L-leucine(out) + L-ornithine(in) + Na(+)(out) => L-leucine(in) + L-ornithine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74301", "l": "D-isoleucine(in) + D-serine(out) => D-isoleucine(out) + D-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47883", "l": "dioctanoylglycerol + H2O <=> H(+) + octanoate + octanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799350", "l": "Exocytosis of specific granule membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0016160", "l": "amylase activity", "d": ["Catalysis of the hydrolysis of amylose or an amylose derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71748", "l": "2-oxoglutarate(out) + L-2-aminoadipate(in) => 2-oxoglutarate(in) + L-2-aminoadipate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-481007", "l": "Exocytosis of platelet alpha granule contents (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64495", "l": "3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] <=> dehydrocitreoisocoumarin + H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050328", "l": "tetrahydroberberine oxidase activity", "d": ["Catalysis of the reaction: (S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15793", "l": "bilirubin IXalpha + NADP(+) = biliverdin IXalpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22004", "l": "ATP + L-seryl-[myosin light chain] = ADP + H(+) + O-phospho-L-seryl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63401", "l": "Fe(II)-hydroxyheme i => Fe(II)-heme a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12000", "l": "formate + NADP(+) = CO2 + NADPH", "d": []}, {"i": "EC:1.17.1.10", "l": "\"formate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202325", "l": "Recruitment of Gads to LAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691004", "l": "XPC binds RAD23 and CETN2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67939", "l": "a 2-hydroxy carboxylate + O2 <=> a 2-oxocarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5632738", "l": "DDIT4 binds 14-3-3 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977239", "l": "Activated IRAK4 bound to activated TLR : MyD88 complex phosphorylates IRAK2    (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047242", "l": "hydroxyanthraquinone glucosyltransferase activity", "d": ["Catalysis of the reaction: a hydroxyanthraquinone + UDP-D-glucose = a glucosyloxyanthraquinone + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334794", "l": "FABPs bind LCFAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68463", "l": "3'-phosphoadenylyl sulfate + a phenolic steroid <=> a phenolic steroid 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71390", "l": "L-pipecolate(in) + Na(+)(in) <=> L-pipecolate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46296", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49450", "l": "alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose => beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607736", "l": "MALT1 oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34691", "l": "(R)-lactoyl-CoA = acryloyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.54", "l": "\"lactoyl-CoA dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395412", "l": "Phosphorylation of SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653514", "l": "USP17L2 deubiquitinates RCE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73535", "l": "CDP(out) + UTP(in) = CDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445700", "l": "Myosin Binds ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140765", "l": "NAD-dependent histone H3K56 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 56) + H2O = histone H3 L-lysine (position 56) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 56 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003885", "l": "D-arabinono-1,4-lactone oxidase activity", "d": ["Catalysis of the reaction: D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44068", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871260", "l": "YAP1 binds TEAD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62976", "l": "(9Z,12Z,15Z)-octadecatrienamide + H2O = (9Z,12Z,15Z)-octadecatrienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201630", "l": "Caspase-mediated cleavage of Acinus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209336", "l": "Activated HOP is autophosphorylated and/or transphosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17097", "l": "3-phenylpyruvate = enol-phenylpyruvate", "d": []}, {"i": "EC:5.3.2.1", "l": "\"phenylpyruvate tautomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809764", "l": "SBF1 binds MTMR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36833", "l": "2 caldariellaquinone + n H(+)(out) + 2 H2O => 2 caldariellaquinol + n H(+)(in) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16868", "l": "choloyl-CoA + propanoyl-CoA <=> 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247847", "l": "WLS is endocytosed to the early endosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41345", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59594", "l": "ADP + beta-alanyl-L-arginine + H(+) + phosphate => ATP + beta-alanine + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40822", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507870", "l": "Aquaporins passively transport water out of cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58803", "l": "3',3'-cGAMP + H2O <=> 5'-pApG-3' + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53565", "l": "9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9732527", "l": "FFAR1 binds rosiglitazone (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68783", "l": "(2Z,6Z)-farnesyl diphosphate <=> alpha-humulene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.-.-", "l": "\"Intramolecular lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42994", "l": "(R)-nephthenol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22461", "l": "a 2,3-saturated acyl-CoA + NADP(+) => a 2,3-dehydroacyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49588", "l": "L-erythrulose 1-phosphate = D-erythrulose 4-phosphate", "d": []}, {"i": "EC:5.3.1.33", "l": "\"L-erythrulose-1-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201630", "l": "Caspase-mediated cleavage of Acinus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766608", "l": "PRMT1 binds type I PRMT inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939335", "l": "RNF181 polyubiquinates BCL10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14980", "l": "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate <=> 3-carboxy-cis,cis-muconate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004128", "l": "cytochrome-b5 reductase activity, acting on NAD(P)H", "d": ["Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381446", "l": "Thrombin proteolyzes IGF:IGFBP3:ALS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005093", "l": "Rab GDP-dissociation inhibitor activity", "d": ["Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17914", "l": "H2O + NAD(+) + nitrite => H(+) + NADH + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190829", "l": "Lysosomal degradation of gap junction plaques (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59240", "l": "L-arginine + L-lysine = L-homoarginine + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031878", "l": "type 1 somatostatin receptor binding", "d": ["Binding to a type 1 somatostatin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706350", "l": "FLT3 phosphorylates CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45295", "l": "2-glyceryl-prostaglandin G2 + AH2 <=> 2-glyceryl-prostaglandin H2 + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71211", "l": "chlorate(out) + 2 Na(+)(out) = chlorate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40279", "l": "(R)-carnitine + dodecanoyl-CoA = CoA + O-dodecanoyl-R-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0000287", "l": "magnesium ion binding", "d": ["Binding to a magnesium (Mg) ion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39337", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+) => 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35629", "l": "delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP => delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75820", "l": "(5Z,8Z)-octadecadienoate + O2 => (5S)-hydroperoxy-(6E,8Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3364014", "l": "Recruitment of SET1 methyltransferase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665699", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382096", "l": "Formation of NR-NCOR Corepressor Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29319", "l": "H2O + sn-glycero-3-phosphoethanolamine = ethanolamine + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32013", "l": "(+)-T-muurolol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661219", "l": "MT1A binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672817", "l": "Active MTORC1 binds the ULK1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867047", "l": "PTPN3 dephosphorylates EPS15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68126", "l": "a triacylglycerol + holo-[ACP] => a 1,2-diacylglycerol + a fatty acyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093331", "l": "Ras:GTP binds p120-RasGAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38339", "l": "(20S)-ginsenoside Rb1 + H2O = (20S)-ginsenoside Rd + D-glucose", "d": []}, {"i": "EC:3.2.1.195", "l": "\"20-O-multi-glycoside ginsenosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64297", "l": "(4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH => (4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140769", "l": "factor VII -> factor VIIa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18086", "l": "coenzyme B + coenzyme M + methanophenazine => coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730903", "l": "Oligomerization of TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69222", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate + D-glucose + H(+) => a (Z)-glucosinolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73000", "l": "H2O + N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide] => L-tryptophan + N-terminal L-alpha-aminoacyl-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44647", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66976", "l": "alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose = alpha-D-Abe-(1->3)-alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": []}, {"i": "EC:2.4.1.382", "l": "\"CDP-abequose:alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und alpha-1,3-abequosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173642", "l": "Disintegration of matrix layer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75780", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoate + H2O => (10S)-hydroxy-(6Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682010", "l": "ATG10:ATG12 binds ATG5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163625", "l": "Glucagon binds to Glucagon receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14777", "l": "AMP + H(+) + H2O = IMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432909", "l": "Interaction of Plectin with Integrin beta 4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68770", "l": "8 AMP + 8 diphosphate + 8 H(+) + PF1022F + 4 S-adenosyl-L-homocysteine => 4 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5096537", "l": "Defective GALNT3 does not transfer GalNAc to mucins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109860", "l": "MAP2K1 phosphorylates MAPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.643449434865403", "identifiers": [{"i": "GO:0008186", "l": "ATP-dependent activity, acting on RNA", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018695", "l": "4-cresol dehydrogenase (hydroxylating) activity", "d": ["Catalysis of the reaction: 4-cresol + acceptor + H2O = 4-hydroxybenzaldehyde + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850945", "l": "Casein kinase II phosphorylates PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60205", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54440", "l": "a (4S)-2,3-dehydroflavan-3,4-diol + H(+) = a 4-H-anthocyanidin with a 3-hydroxy group + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018672", "l": "anthranilate 3-monooxygenase (deaminating) activity", "d": ["Catalysis of the reaction: anthranilate + 2 H+ + NADPH + O2 = 2,3-dihydroxybenzoate + NADP+ + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57342", "l": "3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine => 3-hydroxy-L-kynurenine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42178", "l": "(9Z,12Z)-tetradecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-tetradecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59272", "l": "L-cysteine = D-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77094", "l": "Formation of cap binding complex (CBC) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11834", "l": "H(+) + NADH + naphthalene-1,2-diol => (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61608", "l": "[DsbB protein]-dithiol + a quinone = [DsbB protein]-disulfide + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983147", "l": "Release of E3 from polyubiquitinated substrate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65012", "l": "decanoyl-AMP + holo-[ACP] = AMP + decanoyl-[ACP] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013108", "l": "GDIs block activation of RHOC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381091", "l": "IRE1 dimer autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981353", "l": "RASA1 stimulates RAS GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74438", "l": "a 1-acyl-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> a 1-acyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67648", "l": "dATP + H2O = 2'-deoxyadenosine + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-383190", "l": "HCO3- transport through ion channel (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093331", "l": "Ras:GTP binds p120-RasGAP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43953", "l": "3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 => H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49708", "l": "nocardicin G + S-adenosyl-L-methionine = H(+) + isonocardicin C + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395364", "l": "LTBP4 binds TGF-Beta-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210780", "l": "PDX1-dependent synthesis of NKX6-1 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634850", "l": "NPAS4 binds ARNT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42917", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0023026", "l": "MHC class II protein complex binding", "d": ["Binding to a class II major histocompatibility complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610720", "l": "PKA phosphorylates GLI3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58411", "l": "NADP(+) + undecan-1-ol <=> H(+) + NADPH + undecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24640", "l": "ergosteryl 3-beta-D-glucoside + H2O = D-glucose + ergosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28389", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine <=> di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717658", "l": "SARS-CoV-2 N binds DDX58 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007707", "l": "DLX5,(DLX6) binds RUNX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2471660", "l": "Defective OPN1LW causes CBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12997", "l": "(E)-feruloyl-CoA + galactarate = 2-O-[(E)-feruloyl]-D-galactarate + CoA", "d": []}, {"i": "EC:2.3.1.130", "l": "\"galactarate O-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75471", "l": "thiamine diphosphate(out) = thiamine diphosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016750", "l": "O-succinyltransferase activity", "d": ["Catalysis of the transfer of a succinyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31554", "l": "presqualene diphosphate <=> 15-cis-4,4'-diapophytoene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40296", "l": "ATP + CoA + hexadecanedioate => AMP + diphosphate + hexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66056", "l": "indole-3-pyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46474", "l": "4alpha-hydroxymethylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45344", "l": "globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = globoside NORint (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70487", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O + O2 = a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005528", "l": "FK506 binding", "d": ["Binding to a 23-membered macrolide lactone FK506."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18363", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) => a dolichyl D-xylosyl phosphate + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975633", "l": "atROL binds to RBP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350769", "l": "trans-Golgi Network Coat Activation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17571", "l": "1,2-dehydroreticuline + H(+) + NADPH => (R)-reticuline + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637792", "l": "PLC-gamma 1 binds to p-EGFRvIII mutant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446364", "l": "Migfilin interacts with VASP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19484", "l": "acetyl-CoA + succinyl-CoA <=> 3-oxoadipyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37194", "l": "2',3'-cyclophospho-AMP + H2O <=> adenosine 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810643", "l": "EPPIN protein complex binds bacteria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67377", "l": "glycyl-L-histidine + H2O => glycine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38323", "l": "2 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381668", "l": "cAMP activates EPAC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65897", "l": "glyoxylate + L-kynurenine => glycine + H2O + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39685", "l": "(R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+) => 3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008124", "l": "4-alpha-hydroxytetrahydrobiopterin dehydratase activity", "d": ["Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411365", "l": "Transcription of canonical WNT targets is negatively regulated by NLK-dependent phosphorylation of TCF/LEF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38318", "l": "chorismate <=> 3-hydroxybenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24097", "l": "isoorientin + S-adenosyl-L-methionine => H(+) + isoscoparin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31959", "l": "9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805546", "l": "Keratin type I binds keratin type II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047331", "l": "diphosphate-glycerol phosphotransferase activity", "d": ["Catalysis of the reaction: glycerol + diphosphate = glycerol 1-phosphate + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70986", "l": "glycine(out) + n H(+)(in) <=> glycine(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769397", "l": "SOST binds LRP5/6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786650", "l": "DDHD1,2 hydrolyse PA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950342", "l": "EBI3:CANX binds IL27 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9007539", "l": "CHEK1 phosphorylates E2F6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65479", "l": "1-propanol + butanoyl-CoA <=> CoA + propyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19599", "l": "L-citrulline + NH4(+) => H2O + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59778", "l": "D-arabinose + H2O2 => D-arabinitol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62881", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2 => (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32209", "l": "(3Z)-2-oxohex-3-enedioate => (2E,4Z)-2-hydroxyhexa-2,4-dienedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28968", "l": "L-proline(in) + Na(+)(in) => L-proline(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42357", "l": "(9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15868", "l": "AH2 + O2 + tryptamine <=> 4-hydroxytryptamine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018780", "l": "dichloroacetate halidohydrolase activity", "d": ["Catalysis of the reaction: dichloroacetate + H2O = 2 HCl + glyoxylate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043423", "l": "3-phosphoinositide-dependent protein kinase binding", "d": ["Binding to a 3-phosphoinositide-dependent protein kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54557", "l": "a 5'-end ribonucleotide-tRNA(His) + ATP + H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56627", "l": "2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O <=> 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.68", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071522", "l": "ureidoglycine aminohydrolase activity", "d": ["Catalysis of the reaction: ureidoglycine + H2O = S-ureidoglycolate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865276", "l": "PDGF-AB clevage by Furin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164506", "l": "Gap repair completes provirus integration (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209100", "l": "MYD88:TUB binds to TL receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032854", "l": "NTRK2 phosphorylates CDK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853496", "l": "SCF:FBXL7 binds AURKA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41954", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate => 2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209130", "l": "Full-length SPZ dimer is cleaved by EA/SPE serine protease (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35134", "l": "H(+)(out) + L-alanyl-L-glutamate(out) <=> H(+)(in) + L-alanyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67594", "l": "(R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+) => a 5'-end CoA-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68127", "l": "a 1,2-diacylglycerol + a fatty acyl-[ACP] <=> a triacylglycerol + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35922", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose <=> H(+) + kanamycin D + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59105", "l": "a dolichyl beta-D-glucosyl phosphate + chenodeoxycholate => a dolichyl phosphate + beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29314", "l": "FMNH2 + O2 + sulfoacetate <=> FMN + glyoxylate + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74885", "l": "GUCYs converts GTP to cGMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47250", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate => 2 Fe(III)-[cytochrome c] + L-gulono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202164", "l": "Translocation of PDK1 to Plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669240", "l": "FLNA binds PAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983696", "l": "The Immunoglobulin of the BCR binds antigen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25725", "l": "2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196017", "l": "Dynamin is recruited to the gap junction plaque (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70053", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminoadipate => 2-oxoadipate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990422", "l": "glyoxalase (glycolic acid-forming) activity", "d": ["Catalysis of the reaction: glyoxal + H2O = glycolic acid. Catalysis occurs in the absence of a cofactor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41215", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39599", "l": "3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67066", "l": "A + asnovolin A => AH2 + asnovolin K", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25901", "l": "D-arabino-hex-3-ulose 6-phosphate => beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876472", "l": "NPC2 binds CHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685230", "l": "CHEK1 phosphorylates RAD51 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44693", "l": "a fatty acyl-CoA + hexadecasphinganine => CoA + H(+) + N-acylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21048", "l": "ATP + isopropylamine + L-glutamate = ADP + gamma-L-glutamyl-isopropylamide + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683801", "l": "CHEK2 phosphorylates BRCA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44516", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202721", "l": "JAM2 binds JAM3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55787", "l": "all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate <=> all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42154", "l": "a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5669240", "l": "FLNA binds PAK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004460", "l": "L-lactate dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023462", "l": "Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.13", "l": "\"ABC-type autoinducer-2 transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617758", "l": "EP300,CREBBP acetylate FOXO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47920", "l": "ganglioside GM2 (d18:1(4E)/18:0) + H2O = ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40641", "l": "(9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35209", "l": "H(+) + IMP + phosphate => H2O + IDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578965", "l": "TNRC6A binds AGO2:miRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021596", "l": "Membrane estrogen receptors bind SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785898", "l": "IL4R binds JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624949", "l": "Assembly of the anterograde IFT train (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010349", "l": "L-galactose dehydrogenase activity", "d": ["Catalysis of the reaction: L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63217", "l": "7-cyano-7-carbaguanosine(15) in tRNA + L-lysine => 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296326", "l": "HCAR1 binds LACT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9726580", "l": "PGR binds PGR agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110208", "l": "NTHL1 glycosylase mediated recognition and binding of cytosine glycol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9633044", "l": "ESR binds STRN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50077", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20180", "l": "pyridoxine + UDP-alpha-D-glucose <=> 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604752", "l": "Initial activation of proMMP13 by MMP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29138", "l": "a menaquinol + 2 H(+)(in) + nitrate <=> a menaquinone + 2 H(+)(out) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30790", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62013", "l": "cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000772", "l": "mating pheromone activity", "d": ["The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865605", "l": "BRWD1 binds SMARCA4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18543", "l": "dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine => 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51746", "l": "a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380272", "l": "Plk1-mediated phosphorylation of Nlp (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69608", "l": "acetyl-CoA + N-terminal L-methionyl-[tubulin] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418091", "l": "F2R binds ARRB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209891", "l": "Dopamine is oxidised to noradrenaline (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55998", "l": "beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0032027", "l": "myosin light chain binding", "d": ["Binding to a light chain of a myosin complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40832", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430347", "l": "MigFilin associates with Filamin and F-actin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818682", "l": "MEN1 binds MLL2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.2", "l": "\"carboxypeptidase B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625188", "l": "HSPA8 transports unfolded substrate to lysosomal lumen for degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2314686", "l": "ASA- acetylates PTGS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57588", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59041", "l": "4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30565", "l": "7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate => dimethylallyl diphosphate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005463", "l": "UDP-N-acetylgalactosamine transmembrane transporter activity", "d": ["Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66584", "l": "3-oxocholestane + A + H2O = 25-hydroxy 3-oxocholestane + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865050", "l": "Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203613", "l": "depalmitoylation of eNOS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25674", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}, {"i": "EC:3.1.3.78", "l": "\"phosphatidylinositol-4,5-bisphosphate 4-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3772430", "l": "CTNNBIP1 binds beta-catenin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64631", "l": "acetyl-CoA + octan-1-ol <=> CoA + octyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50197", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433576", "l": "3-dehydrosphinganine + NADPH + H+ => sphinganine + NADP+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21618", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61877", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60606", "l": "1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-tetradecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32563", "l": "(2E)-geranyl diphosphate = alpha-terpinene + diphosphate", "d": []}, {"i": "EC:4.2.3.115", "l": "\"alpha-terpinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140949", "l": "histone H3K9 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl9-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853322", "l": "Plasma membrane FGFR1 fusions dimerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189488", "l": "UROS transforms HMB to URO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25063", "l": "3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) => 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64344", "l": "4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2 = 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54945", "l": "3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31240", "l": "4 H(+) + uroporphyrinogen I => 4 CO2 + coproporphyrinogen I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11474", "l": "an L-alpha-amino acid + formaldehyde + H2O2 => an N-methyl-L-amino acid + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16772", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209272", "l": "N-HH binds to the transmembrane HSPG proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11087", "l": "3-dehydro-L-gulonate + H(+) <=> CO2 + L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863727", "l": "STON2 is neddylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32383", "l": "(1S,2S,4R)-limonene-1,2-diol + NAD(+) = (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109702", "l": "PDPK1 phosphorylates AKT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191636", "l": "Phosphorylation of Cx43 by c-src (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66877", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46233", "l": "(9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22526", "l": "a carotenoid phi-end derivative + 2 AH2 => 2 A + a carotenoid beta-end derivative", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399952", "l": "Phosphorylation of LIMK-1 by PAK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928617", "l": "EPHB2 binds KALRN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50615", "l": "decanal + NADP(+) <=> (2E)-decenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28407", "l": "H2O + XTP => H(+) + phosphate + XDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683593", "l": "ATG7:ATG3:LC3 dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55160", "l": "coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.8.7.3", "l": "\"ferredoxin:CoB-CoM heterodisulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32766", "l": "(3R)-3-methyl-D-ornithine + ATP + L-lysine <=> (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371591", "l": "Trimerization of cytosolic HSF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58810", "l": "AMP + GMP + 2 H(+) => 2',3'-cGAMP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2981040", "l": "COLEC12:ligand is endocytosed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13169", "l": "maleate = fumarate", "d": []}, {"i": "EC:5.2.1.1", "l": "\"maleate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810376", "l": "ING2 binds PI5P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64471", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+) <=> 4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.69", "l": "\"GDP-L-galactose/GDP-D-glucose: hexose 1-phosphate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0016312", "l": "inositol bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65526", "l": "9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60425", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + valerianol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44579", "l": "4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) <=> 2-all-trans-nonaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.n1", "l": "\"peptidoglycan lytic exotransglycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102376", "l": "lupeol 28-oxidase activity", "d": ["Catalysis of the reaction: lupeol + 3 NADPH + 3 O2 + 3 H+ <=> betulinic acid + 3 NADP + 4 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16897", "l": "a 3beta-hydroxysteroid + a triacylglycerol = a 3beta-hydroxysteroid ester + a diacylglycerol", "d": []}, {"i": "EC:2.3.1.77", "l": "\"triacylglycerol--sterol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49065", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol => calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052757", "l": "chondroitin hydrolase activity", "d": ["Catalysis of the hydrolysis of hexosaminic linkages in chondroitin, a linear polymer structure composed of the repeating disaccharide unit [->4)-D-glucuronic acid-(1->3)-N-acetyl-D-galactosamine-(1-], also written as [->4GlcUA1->3GalNAc1-]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696947", "l": "USP47 deubiquitinates POLB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69890", "l": "Na(+)(out) + uridine(out) <=> Na(+)(in) + uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32324", "l": "ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70779", "l": "D-glucose + NADP(+) = 6-dehydro-D-glucose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.432", "l": "\"6-dehydroglucose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41461", "l": "1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine => a 1,2-diacylglycerol + a sphingomyelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57338", "l": "3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP => 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665412", "l": "ERBB2 ECD mutants bind TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-481044", "l": "Surface deployment of platelet alpha granule membrane components (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71977", "l": "glutathione(in) + 3 Na(+)(in) => glutathione(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990002", "l": "methylglyoxal reductase (NADPH-dependent, acetol producing)", "d": ["Catalysis of the reaction: hydroxyacetone + NADP+ = H+ + methylglyoxal + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.36", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050503", "l": "trehalose 6-phosphate phosphorylase activity", "d": ["Catalysis of the reaction: trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68792", "l": "alpha-NAD(+) + H2O = ADP-D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30194", "l": "15-cis-phytoene + plastoquinone-9 <=> 15,9'-di-cis-phytofluene + plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17701", "l": "ATP + geranoyl-CoA + hydrogencarbonate = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.4.1.5", "l": "\"geranoyl-CoA carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-435244", "l": "PECAM1 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612255", "l": "ERBB4s80 binds ADAP1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047112", "l": "pyruvate oxidase activity", "d": ["Catalysis of the reaction: H+ + O2 + phosphate + pyruvate = acetyl phosphate + CO2 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24617", "l": "17beta-estradiol + NADP(+) => estrone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8934742", "l": "RUNX1 binds PRMT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052906", "l": "tRNA (guanine(37)-N(1))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51336", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000327", "l": "PLK1 phosphorylates BORA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4332236", "l": "CBL neddylates TGFBR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678920", "l": "TLR processing at low pH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14786", "l": "RNA(n) + UTP => diphosphate + RNA(n)-3'-uridine ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64758", "l": "benzylthiol + NH4(+) + pyruvate => H2O + S-benzyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873927", "l": "Release of STAT1 dimer from active receptor unit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12735", "l": "5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate => CO2 + diphosphate + nicotinate beta-D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73844", "l": "a 27-hydroxysterol + UDP-alpha-D-glucose => a sterol 27-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046990", "l": "N-hydroxyarylamine O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009936", "l": "RNASEL cleaves cellular ssRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29662", "l": "O-acetyl-L-serine(in) <=> O-acetyl-L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63880", "l": "2 Fe(III)-[cytochrome c] + H2O + thiocyanate = cyanate + 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfur", "d": []}, {"i": "EC:1.8.2.7", "l": "\"thiocyanate desulfurase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53185", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O => 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74709", "l": "5-dehydrofumagillol + H(+) + NADPH => fumagillol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5607734", "l": "PKC-delta translocates to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30786", "l": "D-glyceraldehyde + H2O + NAD(+) <=> (R)-glycerate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28855", "l": "H(+)(in) + melibiose(in) = H(+)(out) + melibiose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59591", "l": "ATP + beta-alanine + L-ornithine <=> ADP + beta-alanyl-L-ornithine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985343", "l": "RUNX2 binds SOX9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18737", "l": "ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate", "d": []}, {"i": "EC:2.7.9.3", "l": "\"selenide, water dikinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67725", "l": "CMP(out) + CMP-N-acetyl-beta-neuraminate(in) => CMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061656", "l": "SUMO conjugating enzyme activity", "d": ["Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10193", "l": "ATP + H2O + sulfate(out) => ADP + H(+) + phosphate + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57592", "l": "(S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50352", "l": "3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH = 3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0004741", "l": "[pyruvate dehydrogenase (lipoamide)] phosphatase activity", "d": ["Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035402", "l": "histone H3T11 kinase activity", "d": ["Catalysis of the reaction: histone H3-threonine (position 11) + ATP = histone H3-phosphothreonine (position 11) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 11 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879222", "l": "MDP:NLRP1 binds ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73757", "l": "Binding of RRN3 to RNA Polymerase I (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29847", "l": "(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019114", "l": "catechol dioxygenase activity", "d": ["Catalysis of the reaction: catechol + O2 = a muconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61836", "l": "ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60907", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> 13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29961", "l": "alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15637", "l": "[alginate](n) + GDP-alpha-D-mannuronate = [alginate](n+1) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653957", "l": "Rag dimer formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13173", "l": "H2O + NAD(+) + phosphonate = H(+) + NADH + phosphate", "d": []}, {"i": "EC:1.20.1.1", "l": "\"phosphonate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28363", "l": "dGTP + H2O => dGMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018619", "l": "benzene 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: benzene + H+ + NADH + O2 = cis-cyclohexa-3,5-diene-1,2-diol + NAD+."]}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0004950", "l": "chemokine receptor activity", "d": ["Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30766", "l": "H2O + L-valine + NAD(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27619", "l": "(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate => di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975040", "l": "KRAB-ZNF / KAP Interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33796", "l": "H2O + sucrose => alpha-D-glucose + beta-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15184", "l": "an acyl-CoA(out) + ATP + H2O <=> ADP + an acyl-CoA(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018746", "l": "RHOQ binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32260", "l": "beta-D-fructose 1-phosphate + methylglyoxal => 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64481", "l": "4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate => (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044594", "l": "17-beta-hydroxysteroid dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31410", "l": "all-trans-4,4'-diaponeurosporene + FAD + H(+) <=> all-trans-4,4'-diapolycopene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177491", "l": "Formation of clathrin-coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17176", "l": "glutathionylspermidine + H2O <=> glutathione + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27988", "l": "H(+) + methylglyoxal + NADPH => hydroxyacetone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247837", "l": "WNT ligands traffic to the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102383", "l": "steviol 19-O glucosyltransferase activity", "d": ["Catalysis of the reaction: steviol + UDP-alpha-D-glucose <=> 19-O-beta-glucopyranosyl-steviol + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61489", "l": "cytidine(50) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52024", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 = 18S-resolvin E2 + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38427", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.90", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391941", "l": "BLT receptors can bind LTB4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72415", "l": "Li(+)(in) + Na(+)(out) = Li(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.242", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445069", "l": "L1-EGFR trans-heterodimerization (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62627", "l": "[glutaredoxin]-dithiol + a hydroperoxide <=> [glutaredoxin]-disulfide + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21135", "l": "H2O + O2 + xanthine <=> H2O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32614", "l": "(6E)-8-hydroxygeranial + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821486", "l": "HCFC1 binds SET1A complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13507", "l": "betaine aldehyde + H2O2 => choline + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2317332", "l": "PIP3 recruits AKT to the membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72637", "l": "1,6-dimethoxyphenazine N(5)-oxide + S-adenosyl-L-homocysteine => 1-hydroxy-6-methoxyphenazine N(10)-oxide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1364044", "l": "PRLR:JAK2 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19575", "l": "[phosphate](n+1) + ADP => [phosphate](n) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9688838", "l": "RIPK3 binds STUB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42836", "l": "acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH = 5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+)", "d": []}, {"i": "EC:2.3.1.236", "l": "\"5-methylnaphthoic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769302", "l": "NPAS4 binds INS gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69106", "l": "H2O + kynurenate + L-cysteine => 2-oxo-3-sulfanylpropanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68297", "l": "dodecanoyl-CoA + L-seryl-[protein] => CoA + O-dodecanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9660192", "l": "VDR agonists bind VDR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59214", "l": "AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase] => holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30097", "l": "a menaquinol + oxaloacetate => (S)-malate + a menaquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59008", "l": "H2O + O2 + salicylaldehyde = H(+) + H2O2 + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36796", "l": "a ribonucleoside 5'-triphosphate + 2 H2O => a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48776", "l": "O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25167", "l": "A + butanoyl-CoA <=> (2E)-butenoyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13554", "l": "alpha-D-galactose + ATP => ADP + alpha-D-galactose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41823", "l": "butanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31826", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> cubebol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424476", "l": "Activation of RAC1 by VAV2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070006", "l": "metalloaminopeptidase activity", "d": ["Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839039", "l": "Tyrosine kinase inhibitors bind and inhibit cytosolic FGFR1 fusion dimer phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49003", "l": "aurachin C + H(+) + NADH + O2 <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75429", "l": "32-hydroxyeburicol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => eburicol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63332", "l": "alpha-L-arabinopyanose = beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28514", "l": "(R)-carnitine + ATP + CoA = (R)-carnitinyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430096", "l": "GP1b-IX-V binds filamin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112690", "l": "PTPN11 binds CBL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20767", "l": "(S)-methylmalonyl-CoA + pyruvate <=> oxaloacetate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52939", "l": "3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O <=> (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690449", "l": "S1PR1 bind S1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25285", "l": "O2 + reduced [NADPH--hemoprotein reductase] + squalene <=> (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851988", "l": "BTN2A2 binds T cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008412", "l": "CDK4 phosphorylates RUNX2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607721", "l": "Activation of NIK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009488", "l": "IL34 binds CSF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28687", "l": "(S)-dihydroorotate + ubiquinone-8 = orotate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68221", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol => (7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.143", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36030", "l": "CoA + NAD(+) + propanal <=> H(+) + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130194", "l": "ABL phosphorylates WAVEs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102025", "l": "ABC-type thiosulfate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiosulfate(out) = ADP + phosphate + thiosulfate(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050031", "l": "L-pipecolate oxidase activity", "d": ["Catalysis of the reaction: L-pipecolate + O2 = 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.3.3", "l": "\"citrate (Re)-synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54959", "l": "ATP + CoA + OPC-6 <=> AMP + diphosphate + OPC-6-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798345", "l": "PXLP-GCAT dimer ligates CoASH to 2A-3OB to form Gly and Ac-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690152", "l": "USP5 cleaves polyubiquitin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18194", "l": "H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] => (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11975", "l": "4 Fe(2+) + 6 H2O + O2 <=> 12 H(+) + 4 iron(III) oxide-hydroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2995330", "l": "COX10 transforms heme to heme O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210444", "l": "L-Glutamate loading of synaptic vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691131", "l": "CANDI binds CUL1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62709", "l": "(indol-3-yl)butanoate + UDP-alpha-D-glucose => 4-(indol-3-yl)butanoyl-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39055", "l": "22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432647", "l": "Phosphorylated PER binds to TIM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26029", "l": "3-aminopropanal + H2O2 + N-acetylputrescine => H2O + N(1)-acetylspermidine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24456", "l": "alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433501", "l": "Interaction of other adapter proteins with p-KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14519", "l": "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA => (E)-feruloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607043", "l": "factor VIIIa associates with cell membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989749", "l": "Expression of ACOX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35985", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28974", "l": "H(+)(in) + shikimate(in) <=> H(+)(out) + shikimate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940100", "l": "CDK1 phosphorylates VCPIP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19454", "l": "2-oxoglutarate + L-alanine => L-glutamate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17306", "l": "H2O + N(omega),N(omega)-dimethyl-L-arginine => dimethylamine + L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69912", "l": "adenosine(out) + 2 Na(+)(out) => adenosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192624", "l": "cRNA Extension (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46763", "l": "2,4-dinitrotoluene + NADH + O2 <=> 4-methyl-5-nitrocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51220", "l": "1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49719", "l": "3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 <=> 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9732629", "l": "PPARG binds PPARG agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640167", "l": "RRAGA,B exchanges GDP for GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25080", "l": "4-methyl-2-oxopentanoate + CO2 => (2S)-2-isopropyl-3-oxosuccinate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.43", "l": "\"(S)-dichlorprop dioxygenase (2-oxoglutarate)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18580", "l": "3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine <=> 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10437", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090684", "l": "contact chemoreceptor activity", "d": ["A non-GPCR transmembrane signaling receptor activity that is responsible for contact chemoreception."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13172", "l": "maleate <=> fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36769", "l": "CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine => 2-hydroxytetracosenoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250280", "l": "ROS oxidize thioredoxin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65387", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O <=> (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627072", "l": "RHOQ binds GOPC:CFTR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40501", "l": "(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20979", "l": "a primary nitroalkane + H2O + O2 <=> an aldehyde + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48075", "l": "ganglioside GM1 (d18:1(4E)) + H2O <=> ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20041", "l": "3-oxopropanoate + H2O + NADP(+) = 2 H(+) + malonate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944216", "l": "Association of procollagen type XV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804425", "l": "TP53 binds POU4F2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158860", "l": "SULT1A1 dimer sulfonates NHABP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35759", "l": "8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676599", "l": "sBAFF trimer binds BAFFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77094", "l": "Formation of cap binding complex (CBC) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75079", "l": "Formation of AT-AC C complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53787", "l": "beta-muricholate + deoxycholoyl-CoA <=> beta-muricholoyl-CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40920", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28583", "l": "ATP + dUDP => ADP + dUTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790087", "l": "HVEM induses BTLA phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28258", "l": "cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate = cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.254", "l": "\"cyanidin-3-O-glucoside 2''-O-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683735", "l": "CHEK2 is recruited to DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23610", "l": "cyanurate + isopropylamine => H(+) + H2O + N-isopropylammelide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888577", "l": "Synthesis of GABA by GAD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13780", "l": "ATP + D-ribose 5-phosphate + NH4(+) <=> 5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247839", "l": "Retromer associates with WLS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66090", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate => L-kynurenine + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43367", "l": "L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose <=> beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36518", "l": "H(+) + malonyl-CoA + tetracosanoyl-CoA <=> 3-oxohexacosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57268", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP = GMP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296043", "l": "Activation of HCN channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31719", "l": "11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374919", "l": "Noradrenaline clearance from the synaptic cleft (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49034", "l": "4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68963", "l": "7,8-dihydroxycoumarin + S-adenosyl-L-methionine <=> 7-hydroxy-8-methoxycoumarin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17398", "l": "a (3R)-hydroxyacyl-[ACP] + NADP(+) => a 3-oxoacyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64059", "l": "(1S,2R)-ephedrine + NAD(+) <=> (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26173", "l": "1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA => CoA + H(+) + mycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061697", "l": "protein-glutaryllysine deglutarylase activity", "d": ["Catalysis of the reaction: H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:47664", "l": "H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940959", "l": "Neurolysin degrades neurotensin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55978", "l": "H(+) + S-sulfanylglutathione + sulfite => glutathione + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190261", "l": "FGFR3c binds to FGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749647", "l": "CES2 hydrolyzes ASA- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31112", "l": "acetyl-CoA + butanoyl-CoA => 3-oxohexanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75848", "l": "9-cis-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => 9-cis-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76044", "l": "(S)-cis-N-methyltetrahydropalmatine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + muramine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39403", "l": "(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH = (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28926", "l": "H(+)(in) + L-phenylalanine(in) <=> H(+)(out) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49635", "l": "(2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate <=> (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2201341", "l": "Endocytosis of TRAM (TICAM2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010307", "l": "acetylglutamate kinase regulator activity", "d": ["Binds to and modulates the activity of acetylglutamate kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49766", "l": "ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O => ethylenediaminetriacetate + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64963", "l": "dTDP + H2O <=> dTMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38393", "l": "(9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72160", "l": "glutarate(in) + taurocholate(out) => glutarate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428909", "l": "Activated TP receptor binds G-protein  G13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031961", "l": "nuclear cortisol receptor binding", "d": ["Binding to a nuclear cortisol receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32932", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol => a cardiolipin + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50042", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+) => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56980", "l": "4-hydroxybenzyl alcohol + 2 oxidized [azurin] = 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69335", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22935", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49340", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin = 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31955", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1458875", "l": "WNT binds to FZD and LRP5/6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57446", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603297", "l": "Defective SLC35D1 does not transport UDP-GlcA, UDPGlcNAc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33504", "l": "ATP + H2O + itraconazole(in) => ADP + H(+) + itraconazole(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2509827", "l": "ITPA hydrolyses ITP to IMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13920", "l": "(-)-menthol + NADP(+) <=> (1R,4S)-menthone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801675", "l": "PLK2 phosphorylates NPM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46825", "l": "4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031861", "l": "prolactin-releasing peptide receptor binding", "d": ["Binding to a prolactin-releasing peptide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75856", "l": "Abortive Initiation Before Second Transition (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56946", "l": "1-deoxy-D-xylulose 5-phosphate + A + H2O => AH2 + D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27683", "l": "ATP + dTDP => ADP + dTTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72060", "l": "glycochenodeoxycholate(out) + 2 Na(+)(out) => glycochenodeoxycholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21726", "l": "a carboxylate + NH4(+) => a nitrile + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462039", "l": "Pro-HNP1-4 are cleaved to biologically active defensin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71732", "l": "citrate(out) + tartrate(in) => citrate(in) + tartrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018768", "l": "RHOU auto-activates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59962", "l": "N(alpha)-acetyl-L-methionine => N(alpha)-acetyl-D-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15616", "l": "NAD(+) + precorrin-2 <=> 2 H(+) + NADH + sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548830", "l": "ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603598", "l": "BAX activation is stimulated by NTRK3(495-641) and NELFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69800", "l": "D-tryptophanyl-tRNA(Trp) + H2O => D-tryptophan + tRNA(Trp)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0106292", "l": "superoxide-generating NADPH oxidase activity", "d": ["Catalysis of the reaction: NADPH + 2 O2 = H+ + NADP+ + 2 superoxide."]}, {"i": "RHEA:63180", "l": "NADPH + 2 O2 = H(+) + NADP(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034863", "l": "2,4,4-trimethyl-1-pentanol dehydrogenase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethyl-1-pentanol = 2,4,4-trimethylpentanal + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15047", "l": "(R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47589", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E)) => CMP + ganglioside GQ1c (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173647", "l": "Transport of trimeric gp41:gp120 to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38603", "l": "NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33836", "l": "H2O + N-hexacosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexacosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863007", "l": "p25-bound CDK5 phosphorylates CDC25B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938063", "l": "SERPINB13 gene expression is inhibited by RUNX1:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15082", "l": "acetate + ATP + CoA => acetyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611839", "l": "β3-agonists bind ADRB3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008809", "l": "carnitine racemase activity", "d": ["Catalysis of the reaction: D-carnitine = L-carnitine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65802", "l": "a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) + L-tyrosine => a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45276", "l": "12-phosphooxy-(9E)-octadecenoate + H2O = 12-hydroxy-(9E)-octadecenoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004561", "l": "alpha-N-acetylglucosaminidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40054", "l": "chorismate <=> 3-[(1-carboxyvinyl)-oxy]benzoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099609", "l": "microtubule lateral binding", "d": ["Binding to the side of a microtubule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687083", "l": "MYC binds MAPKAPK5 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903136", "l": "cuprous ion binding", "d": ["Binding to a cuprous ion, copper(1+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106265", "l": "THPH synthase activity", "d": ["Catalysis of the reaction: 3 H+ + hexanoyl-CoA + 3 malonyl-CoA = 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA."]}, {"i": "RHEA:64352", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA = 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034823", "l": "citronellyl-CoA ligase activity", "d": ["Catalysis of the reaction: citronellate + CoASH + ATP = citronellyl-CoA + AMP + PPi."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55285", "l": "all-trans-retinol + tetradecanoyl-CoA => all-trans-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102841", "l": "1-18:1-2-16:2-monogalactosyldiacylglycerol synthase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:1-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089714", "l": "UDP-N-acetyl-D-mannosamine dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28068", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+) => CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9680443", "l": "ROCK1,2 bind ROCKi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0140998", "l": "histone H2B kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone H2B."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25155", "l": "2-oxoglutarate + L-phenylalanine <=> 3-phenylpyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31092", "l": "acetyl-CoA + dodecanoyl-CoA => 3-oxotetradecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617672", "l": "HOXB3 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52197", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => 1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33985", "l": "diphosphate + miltiradiene => (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39104", "l": "ATP + H2O + sitosterol(in) => ADP + H(+) + phosphate + sitosterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53606", "l": "1-hexadecanoyl-sn-glycerol + phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66250", "l": "AMP + H(+) + IC-asc-C9-CoA => CoA + IC-asc-C9-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989747", "l": "Expression of FHL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55596", "l": "globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine = globoside NORint + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74300", "l": "D-isoleucine(out) + D-serine(in) => D-isoleucine(in) + D-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874685", "l": "CBL binds MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62658", "l": "2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate => 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018592", "l": "4-nitrocatechol 4-monooxygenase activity", "d": ["Catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + nitrite + 1,2,4-benzenetriol."]}]}
{"type": "biolink:MolecularActivity", "ic": "84.755214738114731", "identifiers": [{"i": "GO:0015288", "l": "porin activity", "d": ["Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67818", "l": "a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate => a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097016", "l": "L27 domain binding", "d": ["Binding to a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944225", "l": "Association of procollagen type XVII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981680", "l": "C4b binding protein displaces C2a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14484", "l": "2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O <=> 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13876", "l": "(+)-copalyl diphosphate <=> abieta-7,13-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37750", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine <=> 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193703", "l": "IKKbeta is activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15166", "l": "H2O + O2 + sarcosine => glyoxylate + H2O2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9718379", "l": "GNRHR binds chemical antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848023", "l": "Activated PTK6 binds STAP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22106", "l": "3''-deamino-3''-oxonicotianamine + L-glutamate => 2-oxoglutarate + nicotianamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102603", "l": "12-demethyl-elloramycin C12a O-methyltransferase activity", "d": ["Catalysis of the reaction: 12-demethyl-elloramycin + S-adenosyl-L-methionine <=> elloramycin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.4", "l": "\"serine-type D-Ala-D-Ala carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44376", "l": "a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61635", "l": "5-aminopentanal + H2O + NAD(+) <=> 5-aminopentanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010542", "l": "nitrate efflux transmembrane transporter activity", "d": ["Enables the transfer of nitrate from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229283", "l": "LCNs bind lipids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23351", "l": "(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) <=> (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62834", "l": "GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0032396", "l": "inhibitory MHC class I receptor activity", "d": ["Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38979", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689649", "l": "BAP1 binds BRCA1:BARD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199518", "l": "C3d-complexed antigen binds to complement receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43517", "l": "2-carboxy-5-formylfuran + H2O => 2-carboxy-5-(dihydroxymethyl)furan", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009673", "l": "low-affinity phosphate transmembrane transporter activity", "d": ["Enables the transfer of phosphate from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016617", "l": "4-oxoproline reductase activity", "d": ["Catalysis of the reaction: 4-hydroxy-L-proline + NAD+ = 4-oxoproline + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36207", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004815", "l": "aspartate-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190245", "l": "FGFR1b binds to FGF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.98", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034906", "l": "N-isopropylaniline 1,2-dixoxygenase activity", "d": ["Catalysis of the reaction: N-isopropylaniline + O2 + 2 H+ + NADH = catechol + NAD+ + isopropylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110215", "l": "Cleavage of uracil by UNG glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25030", "l": "ADP-alpha-D-ribose 1''-phosphate + H2O => ADP-D-ribose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977301", "l": "Histidine is decarboxylated to histamine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50519", "l": "acetyl-CoA + N-terminal L-threonyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15593", "l": "amicoumacin A 2-phosphate + H2O = amicoumacin A + phosphate", "d": []}, {"i": "EC:3.1.3.107", "l": "\"amicoumacin phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938913", "l": "RUNX1 binds ELF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8979071", "l": "KDM6B binds iron (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26218", "l": "abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70927", "l": "(R)-glycerate(in) + H(+)(in) = (R)-glycerate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29613", "l": "H(+) + NADPH + 2 nitric oxide => H2O + NADP(+) + nitrous oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874718", "l": "TTPA binds alpha-TOH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52980", "l": "a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] = 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44570", "l": "2-all-trans-hexaprenylphenol + CO2 => 4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693347", "l": "CRYM reduces P2C to PPCA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73750", "l": "(R)-noradrenaline(in) + 2 H(+)(out) <=> (R)-noradrenaline(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71428", "l": "3,3'-diiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) => 3,3'-diiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26548", "l": "beta-alanine + NH4(+) => beta-alaninamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45963", "l": "24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12366", "l": "a quinol + beta-nicotinamide D-riboside => 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65360", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O = a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35195", "l": "L-quinate(in) = L-quinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448678", "l": "CTSG cleaves CASP1(1-404) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71381", "l": "D-aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in) => D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20650", "l": "23,24-dihydrocucurbitacin B + NADP(+) => cucurbitacin B + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58903", "l": "1-carboxybiuret + H2O <=> NH4(+) + urea-1,3-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051508", "l": "stigmasterol UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + stigmasterol = UDP + O-glucosyl-stigmasterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51346", "l": "8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O => (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913374", "l": "Phosphorylated SHC1 recruits SHIP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.7", "l": "\"glutamyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28157", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64143", "l": "an N-(fatty acyl)-L-asparagine + H2O <=> a fatty acid + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22665", "l": "2 1-O-(trans-sinapoyl)-beta-D-glucose => 1,2-di-O-sinapoyl beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353044", "l": "2-phosphoglycerate <=> phosphoenolpyruvate + H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31478", "l": "soyasapogenol B + UDP-alpha-D-glucuronate <=> H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674140", "l": "PAQR3 binds inactive RAFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42172", "l": "(11Z)-eicosenoyl-CoA + AH2 + O2 = (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48401", "l": "2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67392", "l": "2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060230", "l": "lipoprotein lipase activator activity", "d": ["Binds to and increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76007", "l": "(3R)-hydroxybutanoate pentamer + H2O = (3R)-hydroxybutanoate tetramer + (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68615", "l": "Formation of ORC(1-6) complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25041", "l": "H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + 2 phosphate", "d": []}, {"i": "EC:2.9.1.2", "l": "\"O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047639", "l": "alcohol oxidase activity", "d": ["Catalysis of the reaction: a primary alcohol + O2 = an aldehyde + H2O2."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0030305", "l": "heparanase activity", "d": ["Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains."]}, {"i": "REACT:R-HSA-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21004", "l": "(R)-pantolactone + A = 2-dehydropantolactone + AH2", "d": []}, {"i": "EC:1.1.99.27", "l": "\"(R)-pantolactone dehydrogenase (flavin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20656", "l": "23,24-dihydrocucurbitacin B + NAD(+) <=> cucurbitacin B + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853429", "l": "PHLDA1 binds AURKA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75599", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = ectocarpin A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55551", "l": "N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625197", "l": "GFAP binds LAMP2a multimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38572", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) => a 1,2-diacyl-sn-glycero-3-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73907", "l": "4-hydroxy-N,N,N-trimethyltryptamine + ATP = ADP + aeruginascin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444647", "l": "C3a receptor binds anaphylatoxin C3a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9670673", "l": "FIX is secreted (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67403", "l": "(2E,6E)-farnesyl diphosphate <=> allo-aromadendrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74759", "l": "isorhamnetin + S-adenosyl-L-methionine = 3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20117", "l": "ATP + L-rhamnulose = ADP + H(+) + L-rhamnulose 1-phosphate", "d": []}, {"i": "EC:2.7.1.5", "l": "\"rhamnulokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30592", "l": "H2O + O2 + tyramine => (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938231", "l": "RUNX1:CBFB binds CREBBP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71062", "l": "L-arginine(in) + L-leucine(out) <=> L-arginine(out) + L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442862", "l": "Nuclear export of  p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48416", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)) = CMP + ganglioside GM2 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033754", "l": "indoleamine 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14702", "l": "2 CoA + NAD(+) => CoA-disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098848", "l": "alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase activity", "d": ["Catalysis of the reaction: alpha-D-ribose 1-methylphosphonate 5-phosphate = alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + methane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433501", "l": "Interaction of other adapter proteins with p-KIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52436", "l": "a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA = 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52353", "l": "(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14153", "l": "17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.39", "l": "\"steroid N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38930", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990411", "l": "hercynylcysteine sulfoxide lyase activity (ergothioneine-forming)", "d": ["Catalysis of the reaction: hercynylcysteine sulfoxide + 2H+ = ergothioneine + pyruvate + ammonium."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047347", "l": "aldose-1-phosphate nucleotidyltransferase activity", "d": ["Catalysis of the reaction: aldose 1-phosphate + NDP = phosphate + NDP-aldose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626270", "l": "Defective SLC24A4 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54957", "l": "ATP + CoA + OPC-6 => AMP + diphosphate + OPC-6-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73759", "l": "guanosine(2553) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2553) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395340", "l": "Formation of hydroxyallysine by LOX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46885", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21354", "l": "(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+) => 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696958", "l": "USP44 deubiquitinates CDC20 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33726", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0150043", "l": "structural constituent of synapse-associated extracellular matrix", "d": ["The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-606326", "l": "HJURP:CENPA complex localizes to the centromere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.415093686714229", "identifiers": [{"i": "GO:0016854", "l": "racemase and epimerase activity", "d": ["Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule."]}, {"i": "EC:5.1.-.-", "l": "\"Racemases and epimerases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70189", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose => alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62416", "l": "(E)-4-coumaroyl-CoA + H2O = 4-hydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10299", "l": "D-glyceraldehyde 3-phosphate + NADP(+) + phosphate <=> (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380782", "l": "STAT binds to the active receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42318", "l": "an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171122", "l": "LDL + LDLR => LDL:LDLR complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948757", "l": "AKT phosphorylates MKRN1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38300", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103041", "l": "thiosulfate-thioredoxin sulfurtransferase activity", "d": ["Catalysis of the reaction: hydroxidodioxidosulfidosulfate + a reduced thioredoxin = sulfite + hydrogen sulfide + H+ + an oxidized thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828027", "l": "SOX17, TFAP2C, and PRDM1 (BLIMP1) bind the NANOS3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68913", "l": "ATP + H(+) + NADPH + propanoate => AMP + diphosphate + NADP(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209049", "l": "Phosphorylation of AXN and APC by SGG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66336", "l": "L-glutamate(out) = L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.79", "l": "\"granzyme B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43876", "l": "3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA = 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64235", "l": "8 H(+) + holo-[ACP] + 8 malonyl-CoA <=> atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64986", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196026", "l": "Dab2 is recruited to the junctional plaques (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56234", "l": "[(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate => [(1->4)-alpha-D-galacturonosyl](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0010485", "l": "histone H4 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19671", "l": "GDP + H(+) + phosphate => GTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0004971", "l": "AMPA glutamate receptor activity", "d": ["An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209921", "l": "Monoiodinated tyrosine can be deiodinated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33715", "l": "4-hydroxyeicosasphinganine 1-phosphate = 2-hydroxyoctadecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49988", "l": "acetone + H(+) + NADPH + O2 = H2O + methyl acetate + NADP(+)", "d": []}, {"i": "EC:1.14.13.226", "l": "\"acetone monooxygenase (methyl acetate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52324", "l": "2 L-arginine + 4 O2 + 3 reduced [flavodoxin] = 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]", "d": []}, {"i": "EC:1.14.14.47", "l": "\"nitric-oxide synthase (flavodoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16835", "l": "glutathione disulfide + 2 H2O => 2 glutathione + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57904", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016176", "l": "superoxide-generating NADPH oxidase activator activity", "d": ["Binds to and increases the activity of the enzyme superoxide-generating NADPH oxidase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58664", "l": "(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol", "d": []}, {"i": "EC:1.1.5.13", "l": "\"(S)-2-hydroxyglutarate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73069", "l": "an oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] => an N(4)-(oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34913", "l": "D-methionine(out) => D-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34864", "l": "(Z)-2,3-didehydroadipyl-CoA + H2O => 3-hydroxyadipyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71521", "l": "uridine(in) => uridine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674567", "l": "p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74151", "l": "acetyl-CoA + L-lysyl-[beta-tubulin] = CoA + H(+) + N(6)-acetyl-L-lysyl-[beta-tubulin]", "d": []}, {"i": "EC:2.3.1.309", "l": "\"[beta-tubulin]-L-lysine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10028", "l": "D-glutamate + H2O + O2 = 2-oxoglutarate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174070", "l": "Association of Cdh1 with the APC/C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65842", "l": "ATP(in) + Mg(2+)(in) + phosphate(out) => ATP(out) + Mg(2+)(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38847", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36883", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047330", "l": "polyphosphate-glucose phosphotransferase activity", "d": ["Catalysis of the reaction: beta-D-glucose + long chain polyphosphate = glucose-6-phosphate + long chain polyphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.268", "l": "\"tRNA(Thr) (cytosine(32)-N(3))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63185", "l": "NADH + 2 O2 => H(+) + NAD(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888577", "l": "Synthesis of GABA by GAD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.62", "l": "\"glycosylceramidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40163", "l": "D-glyceraldehyde + H2O + NADP(+) = (R)-glycerate + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.89", "l": "\"D-glyceraldehyde dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21930", "l": "2,3-dioxo-L-gulonate + H(+) + NADPH => 3-dehydro-L-gulonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213201", "l": "Formation of collagen fibres (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047048", "l": "3-hydroxybenzyl-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxybenzyl alcohol + NADP+ = 3-hydroxybenzaldehyde + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40212", "l": "(3S)-hydroxytetradecanedioyl-CoA + NAD(+) => 3-oxotetradecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56934", "l": "17beta-hydroxy-androst-5-en-3-one + H(+) + NADH => androst-5-en-3beta,17beta-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693604", "l": "XRCC4:LIG4 ligates DNA DSB ends during NHEJ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59628", "l": "H2O + N(2)-(4-aminobutanoyl)-L-arginine = 4-aminobutanoate + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66696", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936963", "l": "IRAK2 induces TRAF6 oligomerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74038", "l": "D-serine(out) + L-alanine(in) <=> D-serine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40013", "l": "diphosphate + manool => (+)-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2327733", "l": "FN1 binds Collagen types I-V, VII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18254", "l": "(S)-malate + NADP(+) => CO2 + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13133", "l": "CTP + di-trans,poly-cis-dolichol = a dolichyl phosphate + CDP + H(+)", "d": []}, {"i": "EC:2.7.1.108", "l": "\"dolichol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032770", "l": "Translocation of YAP1 to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53996", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22009", "l": "L-homoserine + succinyl-CoA => CoA + O-succinyl-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50604", "l": "acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]", "d": []}, {"i": "EC:2.3.1.259", "l": "\"N-terminal methionine N(alpha)-acetyltransferase NatF\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70319", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 3,4-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61107", "l": "(2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32365", "l": "H(+) + H2O2 + L-ascorbate => L-gulono-1,4-lactone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653886", "l": "B4GALT1 binds LALBA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49541", "l": "(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate => (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.73", "l": "\"u-plasminogen activator\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2059926", "l": "NPHP4 protein binds LATS proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57551", "l": "(S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase] <=> [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65744", "l": "2-oxoglutarate + decyl sulfate + O2 = CO2 + decanal + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802916", "l": "RAF is phosphorylated downstream of moderate kinase activity BRAF mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879942", "l": "The receptor is activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202702", "l": "CD177 binds PECAM-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44993", "l": "(R)-carnitine + 2-methylbutanoyl-CoA => CoA + O-2-methylbutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1671687", "l": "PRLR activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10186", "l": "3-oxoadipate + H(+) => (4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694363", "l": "Dimerisation of nucleoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51404", "l": "H2O + L-arginine + O2 = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)", "d": []}, {"i": "EC:1.4.3.25", "l": "\"L-arginine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9660557", "l": "RAS:GTP binds RAL GDS proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16957", "l": "3',5'-cyclic GMP + H2O = GMP + H(+)", "d": []}, {"i": "EC:3.1.4.35", "l": "\"3',5'-cyclic-GMP phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25096", "l": "ADP + dCDP => ATP + dCMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63281", "l": "a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 => a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33113", "l": "beta-copaene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63821", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) => H(+) + holo-[aryl-carrier protein] + petrobactin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74102", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) <=> ADP + H(+) + L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75850", "l": "Addition of the third nucleotide on the nascent transcript (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18849", "l": "a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase] = a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35628", "l": "delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose => delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46900", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) = a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66678", "l": "4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate => (2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018834", "l": "dichloromethane dehalogenase activity", "d": ["Catalysis of the reaction: dichloromethane + H2O = 2 chloride + formaldehyde + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45709", "l": "3-dehydrocarnitine + acetyl-CoA => 3-dehydrocarnityl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030732", "l": "methionine S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626938", "l": "Beta-catenin binds SOX proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40778", "l": "2-amino-2-phenylacetonitrile + H(+) + 2 H2O <=> D-alpha-phenylglycine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.21", "l": "\"cholesterol 7-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69153", "l": "spermine monoaldehyde => acrolein + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592249", "l": "NRF1, PPRC1, NRF2 bind the TFAM promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-481009", "l": "Exocytosis of platelet dense granule content (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34659", "l": "C30 botryococcene + S-adenosyl-L-methionine = 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473186", "l": "FSTL3 binds Activin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55336", "l": "a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine = a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19414", "l": "ATP + L-phenylalanine + tRNA(Phe) => AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13897", "l": "chorismate = prephenate", "d": []}, {"i": "EC:5.4.99.5", "l": "\"chorismate mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20903", "l": "H(+) + H2O + N-benzyloxycarbonylglycine <=> benzyl alcohol + CO2 + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23069", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA => 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047391", "l": "alkylglycerophosphoethanolamine phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20540", "l": "H2O + holo-[ACP] <=> (R)-4'-phosphopantetheine + apo-[ACP] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801101", "l": "RABGGTA binds RABGGTB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58343", "l": "beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O <=> chenodeoxycholate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218829", "l": "VEGF induces CDC42 activation by unknown mechanism (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004435", "l": "phosphatidylinositol phospholipase C activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-481010", "l": "Surface deployment of platelet dense granule membrane components (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57782", "l": "3-chloro-4-methylcatechol + NAD(+) + nitrite => 2-chloro-4-nitrotoluene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15792", "l": "L-xylose + NADP(+) <=> H(+) + L-xylono-1,4-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15453", "l": "S-adenosyl-L-methionine + sarcosine = H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392152", "l": "Soluble guanylate cyclase converts GTP to cGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67717", "l": "NADPH + 2 oxidized [2Fe-2S]-[protein] => H(+) + NADP(+) + 2 reduced [2Fe-2S]-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56035", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74991", "l": "deoxyerythrostominone(in) = deoxyerythrostominone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371582", "l": "HSBP1 binds HSF1 trimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64200", "l": "an N-(fatty acyl)-L-leucine + H2O = a fatty acid + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169406", "l": "ISGylation of host proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57055", "l": "3-oxoisoapionate + H(+) <=> CO2 + L-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50875", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 <=> (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51155", "l": "2 a thiol + L-cysteinyl-[sulfatase] + O2 <=> 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33001", "l": "(+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => (+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35263", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31927", "l": "3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.109", "l": "\"3-hydroxyindolin-2-one monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35578", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] <=> (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20786", "l": "ADP-D-ribose + L-arginine => H2O + N(omega)-(ADP-D-ribosyl)-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51541", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-706479", "l": "TAK1 is activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20309", "l": "2 H2O2 = 2 H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0061677", "l": "2-dehydro-3-deoxy-D-gluconate aldolase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170964", "l": "FRS2 binds to active TrkA receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65007", "l": "ATP + decanoate + holo-[ACP] <=> AMP + decanoyl-[ACP] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164840", "l": "ADP and Pi bind to ATPase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606602", "l": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67399", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668395", "l": "CHMP7 binds CC2D1B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-481009", "l": "Exocytosis of platelet dense granule content (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851888", "l": "MET binds SHC1-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72080", "l": "3 Na(+)(out) + selenate(out) => 3 Na(+)(in) + selenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047104", "l": "hexadecanal dehydrogenase (acylating) activity", "d": ["Catalysis of the reaction: CoA + NAD+ + palmitaldehyde = H+ + NADH + palmitoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250264", "l": "TXNIP binds reduced thioredoxin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43006", "l": "2-aminoprop-2-enoate + CO2 + NH4(+) => H(+) + O-carbamoyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33549", "l": "H(+) + hexadecanoate + lanosterol => H2O + lanosteryl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54339", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline <=> 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193068", "l": "CYP17A1 17-hydroxylates PREG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49295", "l": "D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] <=> 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1484099", "l": "MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58447", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54579", "l": "2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 <=> an adenosine in tRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52671", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate <=> [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43262", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54585", "l": "a guanosine in 18S rRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749647", "l": "CES2 hydrolyzes ASA- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73898", "l": "ATP + L-glutamate + spermine <=> ADP + gamma-L-glutamylspermine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-179410", "l": "Association of Nek2A with MCC:APC/C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797267", "l": "Expression of CD36 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0019206", "l": "nucleoside kinase activity", "d": ["Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668904", "l": "Formation of the CTF18 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450550", "l": "PKCalpha phosphorylates HuR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783530", "l": "gp130:JAKs bind CNTFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070225", "l": "sulfide dehydrogenase activity", "d": ["Catalysis of the reaction: hydrogen sulfide + oxidized cytochrome c = S + reduced cytochrome c."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804100", "l": "HMGB1 binds LPS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42663", "l": "NAD(+) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43622", "l": "aminoacetaldehyde + CO2 + NADPH => L-serine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497883", "l": "Ferrous iron reduces the BH3 radical back to BH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12401", "l": "beta-nicotinamide D-ribonucleotide + H2O => NH4(+) + nicotinate beta-D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50582", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16638", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine => [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70832", "l": "L-arginine(in) + L-leucine(out) + Na(+)(out) => L-arginine(out) + L-leucine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68554", "l": "H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009541", "l": "ESR1 binds to TFF1 gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31735", "l": "3-oxocholan-24-oyl-CoA + NAD(+) = 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628758", "l": "NEIL1 G83D does not cleave FapyG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67857", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] => 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33789", "l": "3-keto-beta-D-galactose + beta-D-glucose => 3'-ketolactose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18647", "l": "NH4(+) + sym-homospermidine => 2 putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26466", "l": "a 2-demethylmenaquinone + S-adenosyl-L-methionine = a menaquinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13729", "l": "FAD = AMP + H(+) + riboflavin cyclic-4',5'-phosphate", "d": []}, {"i": "EC:4.6.1.15", "l": "\"FAD-AMP lyase (cyclizing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17663", "l": "ADP + phosphate + succinyl-CoA => ATP + CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218820", "l": "Src kinases phosphorylate VAV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416562", "l": "p190RhoGAP binds Plexin-B1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9676255", "l": "Formation of the MLL2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046101", "l": "Peroxisomal beta-oxidation of tetracosapentaenoyl-CoA to Docosapentaenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49585", "l": "D-erythrulose 1-phosphate => L-erythrulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42501", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) => 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41840", "l": "3-oxooctanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.45", "l": "\"UDP-sugar diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211951", "l": "CYP1B1 4-hydroxylates EST17b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111970", "l": "PKC phosphorylates GRK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450533", "l": "PKCdelta phosphorylates HuR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008678", "l": "2-deoxy-D-gluconate 3-dehydrogenase activity", "d": ["Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36661", "l": "novobiocin + phosphate => carbamoyl phosphate + descarbamoylnovobiocin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375384", "l": "Bombesin-like receptors bind bombesin homologues (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46239", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18980", "l": "a quinone + sn-glycerol 3-phosphate <=> a quinol + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61856", "l": "dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2 = betaenone C + 3 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1369028", "l": "ABCAs mediate lipid efflux (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42087", "l": "9-cis-retinal + H2O + NAD(+) <=> 9-cis-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26397", "l": "all-trans-zeaxanthin + 2 O2 = 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": []}, {"i": "EC:1.13.11.84", "l": "\"crocetin dialdehyde synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420121", "l": "SFKs phosphorylate PLCG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18712", "l": "A + H2O + taurine <=> AH2 + NH4(+) + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55892", "l": "a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 = a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351913", "l": "Caspase-mediated cleavage of TJP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357432", "l": "AXL binds SRC-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102436", "l": "7-methylmyricetin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: 7-O-methylmyricetin + S-adenosyl-L-methionine <=> 7,4'-dimethylmyricetin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373024", "l": "isocitrate + NAD+ => 2-oxoglutarate (alpha-ketoglutarate) + CO2 + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794840", "l": "Cipro is oxidized to oxo-Cipro (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24314", "l": "H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine => L-lysyl-[cytochrome c] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62689", "l": "4 norrubrofusarin + O2 => 2 H2O + 2 ustilaginoidin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682377", "l": "LC3 de-lipidation by ATG4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981539", "l": "C3b binds to cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380780", "l": "Activation of Src (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66703", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76016", "l": "(3R)-hydroxybutanoate trimer + H2O => (3R)-hydroxybutanoate dimer + (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.154", "l": "\"corrinoid adenosyltransferase EutT\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.4", "l": "\"dihydrolipoyl dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60257", "l": "A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] => AH2 + formaldehyde + L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70077", "l": "A + clavatol + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine => acetyl-CoA + AH2 + H(+) + 3 malonyl-CoA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667965", "l": "ANKLE2 binds PP2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692880", "l": "HRH3 binds Hist (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64818", "l": "5-aminolevulinate(out) => 5-aminolevulinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11985", "l": "AH2 + O2 + progesterone => A + H2O + testosterone acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66395", "l": "ATP + H2O + prostaglandin E1(in) <=> ADP + H(+) + phosphate + prostaglandin E1(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40490", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140696", "l": "factor V -> factor Va + factor V activation peptide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0030572", "l": "phosphatidyltransferase activity", "d": ["Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59546", "l": "H2O2 + N,N'-diacetylchitobiono-1,5-lactone => N,N'-diacetylchitobiose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509838", "l": "ITPA hydrolyses dITP to dIMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73828", "l": "an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => an alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052687", "l": "(3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP + phosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA."]}, {"i": "KEGG.REACTION:R06396", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67504", "l": "1-nonadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050055", "l": "limonin-D-ring-lactonase activity", "d": ["Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74682", "l": "UDP-beta-L-arabinofuranose(in) + UMP(out) <=> UDP-beta-L-arabinofuranose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46740", "l": "7-dehydrodesmosterol + H(+) + NADPH = desmosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67851", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ATP + CoA <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56405", "l": "[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60213", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180736", "l": "Disassembly of the Rev-importin beta-B23:Ran-GTP complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63083", "l": "AH2 + ATP + ilicicolinate B <=> A + AMP + diphosphate + ilicicolin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60435", "l": "A + cannabigerolate <=> AH2 + cannabichromenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170810", "l": "nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.158", "l": "\"alpha-agarase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39536", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA => (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693111", "l": "RHOF auto-activates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35632", "l": "cyanidin + UDP-alpha-D-galactose => cyanidin 3-O-beta-D-galactoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392749", "l": "Transport of L1 into endosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14260", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46586", "l": "1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.99.-.-", "l": "\"Other isomerases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029453", "l": "Phosphorylation of VAV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31273", "l": "CO2 + H2O + NAD(+) + naphthalene-1,2-diol => 1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114284", "l": "Release of Cytochrome c from mitochondria (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855648", "l": "SALM3 binds LAR-RPTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9656947", "l": "OGG1beta translocates to mitochondria (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247849", "l": "WLS dissociates from retromer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061685", "l": "diphthine methylesterase activity", "d": ["Catalysis of the reaction: diphthine methyl ester + H2O = diphthine + H+ + methanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187575", "l": "Ubiquitination of phospho-p27/p21 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30788", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71752", "l": "2-oxoglutarate(out) + glutarate(in) => 2-oxoglutarate(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41112", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71260", "l": "2 Na(+)(out) + phosphate(out) => 2 Na(+)(in) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46678", "l": "(6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH => (4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74211", "l": "H2O + L-threonyl-tRNA(Lys) = L-threonine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421482", "l": "hydroxymethylbilane => uroporphyrinogen III + H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209160", "l": "Activated ERKs phosphorylate ERF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70780", "l": "D-glucose + NADP(+) => 6-dehydro-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74413", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163090", "l": "Elongation Of The Telomeric Chromosome End (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57050", "l": "2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase] => AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033415", "l": "UGA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UGA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56442", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380241", "l": "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4332359", "l": "Active calmodulin binds CAMK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41782", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide => beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102793", "l": "soyasapogenol B glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate + soyasapogenol B <=> H+ + UDP + soyasapogenol B 3-O-beta-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13692", "l": "diphosphate + glycerol <=> glycerol 1-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036381", "l": "pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate. The reaction occurs in two steps: L-glutamine + H2O = L-glutamate + NH3, and subsequently D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444171", "l": "Receptor FFAR2 binds carboxylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19378", "l": "NADP(+) + reduced riboflavin => 2 H(+) + NADPH + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051022", "l": "Rho GDP-dissociation inhibitor binding", "d": ["Binding to a Rho GDP-dissociation inhibitor protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237129", "l": "Acireductone is created (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009936", "l": "RNASEL cleaves cellular ssRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59851", "l": "(2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH <=> (S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13916", "l": "L-threonine <=> D-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60680", "l": "(+)-artemisinic aldehyde + H2O + NADP(+) = (+)-artemisinate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14379", "l": "glycine + glyoxylate => (3R)-3-hydroxy-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73626", "l": "CTP(out) + GDP(in) <=> CTP(in) + GDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954224", "l": "ERBB4s80:STAT5A binds CSN2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821931", "l": "BOD1L1 binds SET1A complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60997", "l": "H2O + L-leucine + O2 => 4-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41941", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate => [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51708", "l": "D-altritol + NAD(+) = H(+) + keto-D-tagatose + NADH", "d": []}, {"i": "EC:1.1.1.407", "l": "\"D-altritol 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41135", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985594", "l": "MYO9B inactivates RHOA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44634", "l": "2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+) => (3,5-dihydroxyphenyl)acetyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046589", "l": "ribonuclease T1 activity", "d": ["Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58346", "l": "D-glucose + lithocholate => beta-D-glucosyl-(1->3)-O-lithocholate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47872", "l": "ganglioside GM1 + H2O = ganglioside GA1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47714", "l": "cis-3-hydroxy-D-proline => trans-3-hydroxy-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350168", "l": "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390154", "l": "MATS is phosphorylated by HPO dimer and binds to phosphorylated WTS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019767", "l": "IgE receptor activity", "d": ["Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.405", "l": "\"ribitol-5-phosphate 2-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12243", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH <=> 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205286", "l": "GRB2:SOS interacts with p-KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013145", "l": "RAC1 binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71525", "l": "adenine(in) => adenine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640195", "l": "RRAGA,B hydrolyzes GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869694", "l": "oxPL binds CD14 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17702", "l": "ATP + geranoyl-CoA + hydrogencarbonate => 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018462", "l": "4-(hydroxymethyl)benzenesulfonate dehydrogenase activity", "d": ["Catalysis of the reaction: 4-(hydroxymethyl)benzenesulfonate + NAD+ = 4-formylbenzenesulfonate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11557", "l": "(S)-carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517674", "l": "p-S158,221-HuR binds mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000319", "l": "BORA binds PLK1 and AURKA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163310", "l": "TFAM binds to mitochondrial promoters (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10248", "l": "dUTP + H2O = diphosphate + dUMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228992", "l": "ROCK1,ROCK2 are activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140081", "l": "glycosylated region protein binding", "d": ["Binding to a glycosylated region of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61711", "l": "holo-[peptidyl-carrier protein] + L-seryl-5'-AMP <=> AMP + L-seryl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69448", "l": "(2E,6E)-farnesyl diphosphate + H2O = delta-cadinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45127", "l": "acarbose + ATP <=> acarbose 7(IV)-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22812", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH", "d": []}, {"i": "EC:1.5.1.5", "l": "\"methylenetetrahydrofolate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004779", "l": "sulfate adenylyltransferase activity", "d": ["Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615945", "l": "RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851710", "l": "Aberrant alternative splicing yields a secreted FGFR2 IIIa TM disease variant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29063", "l": "a menaquinone + formate + H(+) = a menaquinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015481", "l": "maltose transporting porin activity", "d": ["Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8853496", "l": "SCF:FBXL7 binds AURKA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453183", "l": "p-Y348-SYK dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43194", "l": "2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine => cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71626", "l": "malonate(out) + phosphate(in) <=> malonate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33714", "l": "4-sulfomuconolactone + H2O <=> 2 H(+) + maleylacetate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696146", "l": "AOC2 deaminates TYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37829", "l": "2,4-dichlorophenol + CO2 + pyruvate + succinate => (S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981713", "l": "C4b binds to cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43447", "l": "1,2-ditetradecanoyl-sn-glycerol + ATP <=> 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17681", "l": "3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791118", "l": "Expression of ASNS (Asparagine Synthetase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13371", "l": "diphosphate + isoprene => dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20789", "l": "NAD(+) + phosphate => ADP-alpha-D-ribose 1''-phosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975594", "l": "PLB1 hydrolyses RPALM to atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20132", "l": "AMP + H2O <=> adenine + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68657", "l": "7-oxocholesterol + H(+) + NADPH => 7beta-hydroxycholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41226", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48049", "l": "ganglioside GM1 (d18:1(4E)) + H2O => D-galactose + ganglioside GM2 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944242", "l": "Association of procollagen type XXVII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002428", "l": "Removal of fibrillar collagen N-propeptides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52796", "l": "2 H(+) + Ni-sirohydrochlorin = Ni(2+) + sirohydrochlorin", "d": []}, {"i": "EC:4.99.1.11", "l": "\"sirohydrochlorin nickelchelatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21574", "l": "CO + H(+) + N-acetylanthranilate => 3-hydroxy-2-methyl-1H-quinolin-4-one + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654752", "l": "ATF4 binds the PPP1R15A (GADD34) promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391941", "l": "BLT receptors can bind LTB4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31202", "l": "(3S)-hydroxyoctanoyl-CoA <=> (2E)-octenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5631885", "l": "PRDX1 overoxidizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928607", "l": "p-EPHs bind VAV2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23427", "l": "alpha-D-glucosamine 1-phosphate <=> D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9007901", "l": "IL1F10 binds IL1RL2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163676", "l": "Phosphorylation of pChREBP (Thr 653) at Ser(196) by PKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420206", "l": "Phosphorylation of SRC-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693250", "l": "RHOD binds effectors at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140108", "l": "high-affinity glucose transmembrane transporter activity", "d": ["Enables the transfer of glucose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388832", "l": "PI3K binds CD28 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48752", "l": "2-oxoglutarate + O2 + validamycin A = CO2 + H(+) + succinate + validamycin B", "d": []}, {"i": "EC:1.14.11.52", "l": "\"validamycin A dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199839", "l": "AKT can phosphorylate RSK (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66035", "l": "alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose <=> alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002151", "l": "G-quadruplex RNA binding", "d": ["Binding to a G-quadruplex RNA structure, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34135", "l": "cannabigerolate + O2 = Delta(9)-tetrahydrocannabinolate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917987", "l": "TFRC dimer binds 2xholoTF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13482", "l": "ATP + L-methionine + tRNA(Met) => AMP + diphosphate + L-methionyl-tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864381", "l": "TFAP2A,TFAP2C homodimers bind ESR1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050109", "l": "morphine 6-dehydrogenase activity", "d": ["Catalysis of the reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706328", "l": "Active FLT3 binds to SOCS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57169", "l": "(R)-2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449115", "l": "IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15965", "l": "1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17965", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) = (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55466", "l": "11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352268", "l": "Cleavage of Satb1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63791", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70181", "l": "alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose => 2 D-maltotetraose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111264", "l": "Addition of nucleotides between position +11 and +30 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102501", "l": "D-fructuronate reductase activity", "d": ["Catalysis of the reaction: D-mannonate + NADP = NADPH + H+ + D-fructuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55686", "l": "4-amino-4-deoxychorismate + H2O => chorismate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61180", "l": "quercetin + UDP-alpha-D-glucose = H(+) + quercetin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9010815", "l": "SLITs bind keratan sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865276", "l": "PDGF-AB clevage by Furin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981728", "l": "Factor H binds to membrane-associated C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0005415", "l": "nucleoside:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64966", "l": "dUMP + 2 H(+) + 2 phosphate => dUTP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010296", "l": "prenylcysteine methylesterase activity", "d": ["Catalysis of the reaction: protein C-terminal S-farnesyl-L-cysteine methyl ester + H2O = protein C-terminal S-farnesyl-L-cysteine + methanol + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018603", "l": "nitrobenzene 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: nitrobenzene + NADH + O2 = NAD+ + nitrite + catechol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140801", "l": "histone H2AXY142 kinase activity", "d": ["Catalysis of the reaction: histone H2AX-tyrosine (position 142) + ATP = (histone H2AX-phosphotyrosine (position 142) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 142 of histone variant H2AX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433506", "l": "Phosphorylation of APS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379994", "l": "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17808", "l": "H2O + S-adenosyl-L-homocysteine <=> adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68595", "l": "ORC2 binds ORC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49475", "l": "trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose <=> H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019766", "l": "IgA receptor activity", "d": ["Combining with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749197", "l": "ORC1 binds to H4K20me2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371353", "l": "Soluble TNF-α binds TNFR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636397", "l": "PtpA binds ATP6V1H (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626228", "l": "The distal appendage proteins recruit TTBK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38137", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71884", "l": "GMP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-GMP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693536", "l": "ATM phosphorylates MDC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55734", "l": "19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56297", "l": "2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein] => pyruvate + S-sulfanyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2134532", "l": "TGFBR2 phosphorylates TGFBR1 and PARD6A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73107", "l": "acacetin + S-adenosyl-L-methionine = apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66034", "l": "alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose => alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35894", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65626", "l": "CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine => hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700149", "l": "Active ALK binds PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63989", "l": "2-thiocytidine + ATP => 2-thiocytidine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33354", "l": "hexacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-hexacosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390929", "l": "HTR1 and 5A receptors can bind serotonin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30717", "l": "(S)-linalool => (2E)-geraniol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70911", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate = (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798257", "l": "PTPRS binds NTRK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5660663", "l": "Caspase-8 cleaves IL1B precursor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45566", "l": "5-epi-valiolone => 2-epi-5-epi-valiolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63367", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2 <=> (S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18554", "l": "(2R,3S)-tartrate + NAD(+) => dihydroxyfumarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036434", "l": "nitronate monooxygenase (FMN-linked) activity", "d": ["Catalysis of the reaction: ethylnitronate + FMNH(2) + O2 = acetaldehyde + FMN + H2O + H+ + nitrite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654399", "l": "Activated FGFR2 binds FRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30105", "l": "5-dehydro-D-gluconate + NAD(+) => 2,5-didehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39646", "l": "(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH <=> (18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990948", "l": "ubiquitin ligase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a ubiquitin ligase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432652", "l": "Nuclear CRY is degraded by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50083", "l": "ATP + H2O + taurodeoxycholate(in) <=> ADP + H(+) + phosphate + taurodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043803", "l": "hydroxyneurosporene-O-methyltransferase activity", "d": ["Catalysis of the reaction: demethylspheroidene + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + spheroidene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32139", "l": "ATP + CoA + malonate = AMP + diphosphate + malonyl-CoA", "d": []}, {"i": "EC:6.2.1.76", "l": "\"malonate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45889", "l": "12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50911", "l": "a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 <=> A + a 3-demethylubiquinol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392295", "l": "Gbeta:gamma recruits PI3K gamma (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83788", "l": "Binding of TFIIIC to Type 2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74755", "l": "kaempferide + S-adenosyl-L-methionine = 3,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19283", "l": "acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen => (7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008657", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53694", "l": "H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine => 2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68281", "l": "L-seryl-[protein] + pentanoyl-CoA => CoA + O-pentanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014342", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047578", "l": "4-hydroxyglutamate transaminase activity", "d": ["Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51682", "l": "(2E,6E)-farnesyl phosphate + CDP + H(+) => (2E,6E)-farnesol + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17517", "l": "H2O + N-(long-chain-fatty-acyl)-L-glutamate = a long-chain fatty acid + L-glutamate", "d": []}, {"i": "EC:3.5.1.55", "l": "\"long-chain-fatty-acyl-glutamate deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43380", "l": "H2O + N(omega)-phospho-L-arginyl-[protein] = L-arginyl-[protein] + phosphate", "d": []}, {"i": "EC:3.9.1.2", "l": "\"protein arginine phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62651", "l": "(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 <=> (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66037", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23657", "l": "2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate => 3-carboxy-cis,cis-muconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18051", "l": "L-glutamate + N-acetyl-L-glutamate 5-semialdehyde => 2-oxoglutarate + N(2)-acetyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187828", "l": "Translocation of p21 to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31457", "l": "2 H(+) + NADH + riboflavin => NAD(+) + reduced riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209891", "l": "Dopamine is oxidised to noradrenaline (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53700", "l": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047079", "l": "deoxyuridine 1'-dioxygenase activity", "d": ["Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O2 = 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026493", "l": "p-Y516 of p-5Y-NTRK2 recruits SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46352", "l": "(2E)-decenoyl-CoA + H2O = 3-hydroxydecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54546", "l": "1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050383", "l": "uracil dehydrogenase activity", "d": ["Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65630", "l": "CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine => sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10266", "l": "beta-D-glucose => alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667965", "l": "ANKLE2 binds PP2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29635", "l": "D-maltopentaose + H2O = alpha-D-glucose + D-maltotetraose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34183", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose = alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1297333", "l": "Association of Acrosin Heavy and Light Chain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76068", "l": "(S)-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-methionine => (S)-cis-N-methyl-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22049", "l": "7,8-dihydroneopterin 3'-triphosphate => 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11797", "l": "ecdysone + O2 => 3-dehydroecdysone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694261", "l": "nsp9 forms a homotetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23113", "l": "6-methylsalicylate + H(+) => 3-methylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67861", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] => 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26361", "l": "L-tyrosine + NADPH + S-adenosyl-L-methionine = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)", "d": []}, {"i": "EC:4.1.99.19", "l": "\"2-iminoacetate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052876", "l": "methylamine dehydrogenase (amicyanin) activity", "d": ["Catalysis of the reaction: 2O + methylamine + 2 oxidized [amicyanin] = formaldehyde + 2 H+ + NH4+ + 2 reduced [amicyanin]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11566", "l": "alpha-D-glucose 1-phosphate + D-gluconate => 4-O-beta-D-glucopyranosyl-D-gluconate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52295", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20441", "l": "L-cysteine + O2 = 3-sulfino-L-alanine + H(+)", "d": []}, {"i": "EC:1.13.11.20", "l": "\"cysteine dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9828175", "l": "Formation of the NSL complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34093", "l": "(S)-2-amino-6-oxohexanoate + NH4(+) + phosphate => (5R)-5-phosphooxy-L-lysine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28057", "l": "2-oxobutanoate + CoA <=> formate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31405", "l": "all-trans-4,4'-diaponeurosporene + FADH2 => all-trans-4,4'-diapo-zeta-carotene + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417820", "l": "P2Y9 receptor can bind to LPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382061", "l": "Extracellular processing of novel PDGFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59123", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+) <=> 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10363", "l": "3,4-dihydrocoumarin + H2O <=> 3-(2-hydroxyphenyl)propanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74965", "l": "L-leucine(in) + L-ornithine(out) + Na(+)(in) => L-leucine(out) + L-ornithine(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67356", "l": "(2S)-naringenin 7-O-beta-D-glucoside + malonyl-CoA = (2S)-naringenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114256", "l": "CYCS:APAF1 binds procaspase-9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016807", "l": "cysteine-type carboxypeptidase activity", "d": ["Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015325", "l": "acetyl-CoA:CoA antiporter activity", "d": ["Catalysis of the reaction: acetyl-CoA(out) + CoA(in) = acetyl-CoA(in) + CoA(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55245", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4beta-methylzymosterol-4alpha-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19807", "l": "a purine nucleobase + alpha-D-ribose 1-phosphate => a purine D-ribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33197", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4518575", "l": "miR-92b binds 3'UTR of NLK mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25073", "l": "3-hydroxybenzoate + ATP + CoA <=> 3-hydroxybenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732822", "l": "nsp3 binds to PLpro inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937814", "l": "RUNX3 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67070", "l": "A + asnovolin J => AH2 + chermesin D methyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43084", "l": "cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35080", "l": "doxorubicin(in) => doxorubicin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667914", "l": "ALK binds ligand midkine (MDK) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18113", "l": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417898", "l": "P2Y4 receptor can bind to UTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71588", "l": "(S)-malate(in) + 2-oxoglutarate(out) => (S)-malate(out) + 2-oxoglutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863973", "l": "Fusion of ERC and phagosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197691", "l": "WIP binds WASP,N-WASP, activating them (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798743", "l": "Exocytosis of secretory granule membrane proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34107", "l": "glycine + H(+) + hexadecanoyl-CoA = 1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33727", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine = a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-383190", "l": "HCO3- transport through ion channel (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67564", "l": "3'-phosphoadenylyl sulfate + chenodeoxycholate = adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615042", "l": "Viral 2',5'-PDE cleaves 2'-5' oligoadenylates  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947535", "l": "Cyclisation of GTP to precursor Z (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203611", "l": "N-myristoylation of eNOS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34194", "l": "(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13402", "l": "(2E,6E)-farnesol => (2Z,6E)-farnesol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37150", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55987", "l": "(R)-mandelonitrile + UDP-alpha-D-glucose <=> (R)-prunasin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24385", "l": "ATP + deamido-NAD(+) + H2O + L-glutamine => AMP + diphosphate + H(+) + L-glutamate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698179", "l": "FLT3 mutants recruit PIK3R1 through phosphorylated GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51824", "l": "ATP(in) + CoA(in) + H(+)(out) + octanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788975", "l": "Superoxide anion dismutates to H2O2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678843", "l": "ISGylation of protein translation regulator 4EHP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390886", "l": "HRH4 binds Hist (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202960", "l": "Caspase mediated cleavage of C-IAP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43469", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => (8Z,10E,14Z)-12-hydroperoxyeicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51432", "l": "(S)-1-aminoethylphosphonate + acetyl-CoA = [(1S)-1-acetamidoethyl]phosphonate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35731", "l": "sn-glycerol 3-phosphate + tetradecanoyl-CoA = 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71008", "l": "L-phenylalanine(out) + L-tryptophan(in) => L-phenylalanine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41080", "l": "1-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61225", "l": "H2O + L-asparagine + O2 => 2-oxosuccinamate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692764", "l": "MAPK6 binds CCND3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218832", "l": "CDC42:GTP binds PAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37416", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43411", "l": "sphinganine + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60746", "l": "CoA + pyrethrin I => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29149", "l": "2 H(+)(out) + H2O + nitrite + ubiquinone-8 => 2 H(+)(in) + nitrate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177934", "l": "EGFR autophosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51674", "l": "glycolate + H(+) => glyoxal + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9659611", "l": "ANO1 inhibitors bind ANO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50844", "l": "(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74448", "l": "Calcium binds calmodulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50692", "l": "ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate = ADP + alpha-maltose 1-phosphate + H(+)", "d": []}, {"i": "EC:2.4.1.342", "l": "\"alpha-maltose-1-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23181", "l": "a secondary alcohol + O2 => a ketone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199144", "l": "Nectin 2 binds CD226 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912734", "l": "CBL:CRKL binds RAPGEF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49491", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate <=> 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12803", "l": "ADP + H(+) + O-phospho-L-seryl-[tau protein] => ATP + L-seryl-[tau protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0047545", "l": "2-hydroxyglutarate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052675", "l": "3-methylbutanol:NADP oxidoreductase activity", "d": ["Catalysis of the reaction: 3-methylbutanol + NADP+ = 3-methylbutanal + NADPH + H+. 3-methylbutanal is also known as isovaleraldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.3", "l": "\"sirohydrochlorin cobaltochelatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014812", "l": "ROBOs bind keratan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465940", "l": "atRAL is reduced to atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419223", "l": "5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + adenosine 5'-diphosphate + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71906", "l": "guanine + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-guanine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200406", "l": "CPT1A,B transfers PALM to CAR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008404", "l": "arachidonic acid 14,15-epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid."]}, {"i": "RHEA:51472", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621406", "l": "EGR2 and SREBF2 dimer bind CYP51A1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67622", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48996", "l": "3-methylcatechol + O2 = 2-hydroxy-6-oxo-2,4-heptadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679044", "l": "FKBP1A binds sirolimus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22624", "l": "(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate", "d": []}, {"i": "EC:4.1.3.39", "l": "\"4-hydroxy-2-oxovalerate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392748", "l": "L1 binds to AP-2 Clathrin complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9703895", "l": "CASR binds CASR agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785898", "l": "IL4R binds JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31263", "l": "but-3-ynal + H(+) + pyrroloquinoline quinol = but-3-yn-1-ol + pyrroloquinoline quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209815", "l": "Tyrosine is monoiodinated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37164", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.958976004066542", "identifiers": [{"i": "GO:0004559", "l": "alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247513", "l": "STAB1:ligand is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67615", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34727", "l": "H2O + N-acyl-15-methylhexadecasphinganine = 15-methylhexadecasphinganine + a carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41868", "l": "decanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22357", "l": "diphosphate + oxaloacetate => CO2 + phosphate + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036191", "l": "indolin-2-one monooxygenase activity", "d": ["Catalysis of the reaction: indolin-2-one + NAD(P)H + H+ + O2 = 3-hydroxyindolin-2-one + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71197", "l": "H(+)(in) + Zn(2+)(in) => H(+)(out) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51955", "l": "(E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71178", "l": "2 chloride(out) + glycine betaine(out) + 3 Na(+)(out) <=> 2 chloride(in) + glycine betaine(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018548", "l": "pentaerythritol trinitrate reductase activity", "d": ["Catalysis of the reaction: pentaerythritol trinitrate + NADPH = NADP+ + nitrate + pentaerythritol dinitrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20297", "l": "an anilide + H2O = a carboxylate + aniline + H(+)", "d": []}, {"i": "EC:3.5.1.13", "l": "\"aryl-acylamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371590", "l": "HSP70 binds to HSP40:nascent protein (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187382", "l": "Degradation of ubiquitinated SMAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66415", "l": "ATP + glutathione(in) + H2O + taurochenodeoxycholate(in) <=> ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63698", "l": "H(+) + SN-38 O-beta-D-glucuronide + UDP => SN-38 + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75083", "l": "32-oxo-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132261", "l": "Complement factor H binds to C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28327", "l": "H2O + wogonin 7-O-beta-D-glucuronate => D-glucuronate + H(+) + wogonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31469", "l": "bis(beta-D-glucosyl) crocetin + UDP => beta-D-glucosyl crocetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653974", "l": "Ragulator binds Rag dimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570528", "l": "SUMOylation of XPC with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57830", "l": "2-deoxy-D-ribose 5-phosphate + hypoxanthine => dIMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202245", "l": "Phosphorylation of TBSMs in LAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427570", "l": "Group 3 - Selective Cl- transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25981", "l": "(5S)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74579", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein] = N-acetyl-L-cysteine + N-terminal L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374669", "l": "L1 binds NRP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35898", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392064", "l": "G alpha (z) inhibits adenylate cyclase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483219", "l": "PC is exchanged with PI by PITPNB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39874", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17077", "l": "H2O + N,N-dimethylglycine + O2 = formaldehyde + H2O2 + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964284", "l": "BTK in active Gq-BTK complex is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58333", "l": "(E)-non-2-en-1-ol + NADP(+) => (E)-non-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645694", "l": "p14ARF binds C1QBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392195", "l": "Gi activation by P2Y purinoceptor 12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35796", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine => H(+) + kanamycin A + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61880", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27324", "l": "3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19421", "l": "(R)-2-hydroxypropyl-coenzyme M = (R)-1,2-epoxypropane + coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134954", "l": "DHX9 binds DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52773", "l": "7,8-dihydroneopterin 3'-triphosphate => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451309", "l": "Edited Kainate Receptor binds glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18858", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002083", "l": "4-hydroxybenzoate decaprenyltransferase activity", "d": ["Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199014", "l": "CD96 binds PVR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685319", "l": "CX3 complex formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070906", "l": "aspartate:alanine antiporter activity", "d": ["Catalysis of the reaction: aspartate(out) + alanine(in) = aspartate(in) + alanine(out)."]}, {"i": "RHEA:33139", "l": "L-alanine(out) + L-aspartate(in) = L-alanine(in) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59473", "l": "2',3'-cGAMP + H2O => Gp(2'-5')Ap(3') + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51924", "l": "AH2 + menaquinone-9 = A + beta-dihydromenaquinone-9", "d": []}, {"i": "EC:1.3.99.38", "l": "\"menaquinone-9beta-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33686", "l": "H(+) + L-serine + octadecanoyl-CoA <=> 3-oxoeicosasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72307", "l": "L-glutamate(in) + taurocholate(out) = L-glutamate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851890", "l": "MET phosphorylates SHC1-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31920", "l": "indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] => 3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71782", "l": "4-methyl-2-oxopentanoate(out) + H(+)(out) <=> 4-methyl-2-oxopentanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983307", "l": "IL15 binds IL15RA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917730", "l": "Cargo Recognition And Sorting (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043221", "l": "SMC family protein binding", "d": ["Binding to a protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71202", "l": "L-ornithine(in) <=> L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31143", "l": "(3S)-hydroxyhexanoyl-CoA + NAD(+) = 3-oxohexanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56352", "l": "4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 = 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51954", "l": "2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38262", "l": "(2R,3S)-beta-methylmalyl-CoA <=> glyoxylate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24613", "l": "17beta-estradiol + NAD(+) => estrone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390909", "l": "HRH2 binds hist (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39465", "l": "(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O => (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75229", "l": "H(+) + L-xylonate => H2O + L-xylono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54031", "l": "a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40768", "l": "(20S)-ginsenoside R1 + H2O => (20S)-ginsenoside Rg1 + D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690702", "l": "LYN phosphorylates CD22 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43302", "l": "H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP => alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16649", "l": "(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.102", "l": "\"N-methylcoclaurine 3'-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74196", "l": "aspulvinone E + O2 => (5Z)-3-(3,4-dihydroxyphenyl)-5-[(3,4-dihydroxyphenyl)methylidene]-5-oxo-2,5-dihydrofuran-3-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392870", "l": "Gs activation by prostacyclin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67444", "l": "an (R)-2-hydroxy-long-chain-fatty acyl-CoA = a long-chain fatty aldehyde + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10034", "l": "[protein]-C-terminal-L-glutamate + NH4(+) => [protein]-C-terminal-L-glutamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805785", "l": "AKT phosphorylates PHF20 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68575", "l": "L-tyrosine(in) <=> L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54987", "l": "a ubiquinol <=> a ubiquinone + 2 e(-) + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760103", "l": "AcK-NFE2L2 binds the GCLM gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16536", "l": "L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71558", "l": "5-C(alpha)-glycyl-dTMP in DNA + H(+) <=> 5-aminoethyl-dUMP in DNA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981539", "l": "C3b binds to cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20411", "l": "D-glucose + FMN => alpha-D-glucose 1-phosphate + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18426", "l": "L-quinate + NADP(+) => 3-dehydroquinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008790", "l": "arabinose isomerase activity", "d": ["Catalysis of the reaction: D-arabinose = D-ribulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40269", "l": "3-oxohexadecanedioyl-CoA + H(+) + NADH => (3S)-hydroxyhexadecanedioyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40367", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9732629", "l": "PPARG binds PPARG agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43830", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050317", "l": "tagatose kinase activity", "d": ["Catalysis of the reaction: D-tagatose + ATP = D-tagatose 6-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45506", "l": "(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit] => phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62682", "l": "H(+) + H2O + norrubrofusarin => naphtopyrone YWA1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16996", "l": "6 Fe(III)-[cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] <=> 6 Fe(II)-[cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74932", "l": "2 2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + 2 O2 => a (3R)-3-isocyanyl-fatty acid + 3 CO2 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53194", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193703", "l": "IKKbeta is activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254251", "l": "ERBB4s80 binds YAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "43.58752430622183", "identifiers": [{"i": "GO:0038023", "l": "signaling receptor activity", "d": ["Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873917", "l": "Translocation of STAT1 dimer to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20112", "l": "alpha-D-ribose 1,5-bisphosphate + ATP <=> 5-phospho-alpha-D-ribose 1-diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113402", "l": "Formation of DSIF:NELF:early elongation complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47109", "l": "cholate + taurine => H2O + taurocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59399", "l": "L-leucine <=> D-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211950", "l": "CYP24A1 24-hydroxylates CTL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64546", "l": "8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine => acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061775", "l": "cohesin loader activity", "d": ["Facilitating a conformational change to load a cohesin complex around sister chromatids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70869", "l": "L-alanine(in) + L-glutamine(out) + Na(+)(in) => L-alanine(out) + L-glutamine(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70899", "l": "histidine => urocanate + NH4+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022872", "l": "MECP2 binds MOBP gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28448", "l": "1-deoxy-D-xylulose(out) => 1-deoxy-D-xylulose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60268", "l": "N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60944", "l": "quercetin + S-adenosyl-L-methionine = H(+) + isorhamnetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.28", "l": "\"L-cysteine desulfidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63624", "l": "hexadecanoyl-AMP + holo-[ACP] = AMP + H(+) + hexadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30382", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-beta-chamigrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047558", "l": "3-cyanoalanine hydratase activity", "d": ["Catalysis of the reaction: L-asparagine = 3-cyano-L-alanine + H2O + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22143", "l": "a nucleoside 5'-phosphate + H2O <=> a nucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1564169", "l": "Collagen type VIII degradation by MMP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159868", "l": "Furin cleaves pro-factor VII to factor VII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31981", "l": "H2O + NADP(+) + trimethylamine N-oxide => NADPH + O2 + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.3.2", "l": "\"NAD(P)H oxidase (H2O-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67976", "l": "all-trans-neurosporene = beta-zeacarotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805126", "l": "AURKB phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102405", "l": "(+)-taxifolin 5'-hydroxylase activity", "d": ["Catalysis of the reaction: (+)-taxifolin(1-) + O2 + NADPH(4-) + H+ <=> (+)-dihydromyricetin + NADP(3-) + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58314", "l": "25-substituted-cholesterol + D-glucose => 25-substituted-cholesteryl beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322429", "l": "XIAP monoubiquinates TLE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44423", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54726", "l": "3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008894", "l": "PTPNs gene transcription and translation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928578", "l": "EPH receptors autophosphorylate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72468", "l": "2 acetyl-CoA + 5 H(+) + 6 malonyl-CoA => 6 CO2 + 8 CoA + H2O + o-orsellinate depside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15645", "l": "16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] = 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate", "d": []}, {"i": "EC:1.19.6.1", "l": "\"nitrogenase (flavodoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64636", "l": "benzoyl-CoA + butan-1-ol = butyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047204", "l": "chlorogenate-glucarate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: D-glucarate + chlorogenate = (-)-quinate + 2-O-caffeoylglucarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9681375", "l": "KIT binds ripretinib (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56815", "l": "2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 <=> 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002058", "l": "uracil binding", "d": ["Binding to uracil."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250280", "l": "ROS oxidize thioredoxin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866277", "l": "AP-2 directly binds some endocytic cargo (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:1990459", "l": "transferrin receptor binding", "d": ["Binding to a transferrin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59425", "l": "benzylamine + H2O + O2 => benzaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950347", "l": "IL12A:IL12B translocates from late endosome lumen to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067659", "l": "Assembly of hexameric IL-6 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047100", "l": "glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity", "d": ["Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944457", "l": "MAF1 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5633051", "l": "EFCAB7:IQCE binds EVC2:EVC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47323", "l": "(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate <=> 3-oxo-3-phenylpropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61503", "l": "delphinidin + UDP-alpha-D-glucose <=> delphinidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4570528", "l": "SUMOylation of XPC with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16319", "l": "H(+) + indan-1-one + NADH => (S)-indan-1-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683831", "l": "CCDC59 binds TTF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679028", "l": "JAK3 binds JAK3 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37736", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75244", "l": "FASL binds FAS Receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11377", "l": "(19E)-geissoschizine + NADP(+) => 4,21-dehydrogeissoschizine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73823", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40024", "l": "9alpha-copalyl diphosphate + H2O => diphosphate + syn-copalol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25065", "l": "3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) <=> 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.3.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788623", "l": "p-Y-STATs translocate to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17340", "l": "catechol + O2 <=> (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.6", "l": "\"nucleoside diphosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55411", "l": "[phosphate](n) + CTP <=> [phosphate](n+1) + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801109", "l": "CHM binds RGGT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36476", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA => (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167121", "l": "Addition of the third nucleotide on the nascent HIV-1 transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51555", "l": "D-sorbitol + NADP(+) <=> H(+) + L-xylo-3-hexulose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9702849", "l": "CALCR binds gepants (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683774", "l": "p-T68-CHEK2 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68009", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (2E,6E,10E)-geranylgeranyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198813", "l": "GSTO dimers reduce DeHA to AscH- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939335", "l": "RNF181 polyubiquinates BCL10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668395", "l": "CHMP7 binds CC2D1B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654603", "l": "Activated FGFR2 binds FRS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49285", "l": "8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP => CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.070741307315856", "identifiers": [{"i": "GO:0016721", "l": "oxidoreductase activity, acting on superoxide radicals as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor."]}, {"i": "EC:1.15.-.-", "l": "\"Acting on superoxide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39793", "l": "20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33132", "l": "L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate => 3-phenylpyruvate + tetrahydrotyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032547", "l": "purine deoxyribonucleoside binding", "d": ["Binding to a purine deoxyribonucleoside, a compound consisting of a purine base linked to deoxyribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8960973", "l": "RLBP1:11cRAL dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58543", "l": "2 L-ascorbate + N-dodecanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50268", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193832", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218812", "l": "FYN phosphorylates PAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72095", "l": "Internal Methylation of mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25217", "l": "acetyl-CoA + serotonin = CoA + H(+) + N-acetylserotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404140", "l": "NREH hydrolyses atREs to atROL and FAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71412", "l": "3,3',5-triiodo-L-thyronine(out) + L-tryptophan(in) => 3,3',5-triiodo-L-thyronine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174119", "l": "Free APC/C phosphorylated by Plk1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52202", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O => 1-aci-nitro-2-(phenyl)ethane + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.284", "l": "\"3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018574", "l": "2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2,6-dichlorohydroquinone + O2 + H2O = HCl + 2 H+ + 2-chloromaleylacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62738", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate => 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75824", "l": "Ubiquitination of Cyclin D1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592235", "l": "Expression of POLG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051743", "l": "red chlorophyll catabolite reductase activity", "d": ["Catalysis of the reaction: red chlorophyll catabolite + reduced ferredoxin + 2 H+ = primary fluorescent catabolite + oxidized ferredoxin. This reaction is the reduction of the C20/C1 double bond in the pyrrole system of red chlorophyll catabolite (RCC) to a colorless tetrapyrrole (pFCC) with a strong blue fluorescence."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54595", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3215406", "l": "PRMT5 binds WDR77 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10981", "l": "L-serine => D-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17862", "l": "21-hydroxyprogesterone => 20-hydroxy-3-oxopregn-4-en-21-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10019", "l": "H2O + O-sinapoylcholine <=> (E)-sinapate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15796", "l": "bilirubin IXalpha + NADP(+) <=> biliverdin IXalpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2430535", "l": "MASTL phosphorylates ENSA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40809", "l": "(9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15437", "l": "a long-chain fatty aldehyde + CoA + NADP(+) = a long-chain fatty acyl-CoA + H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.50", "l": "\"long-chain-fatty-acyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902936", "l": "phosphatidylinositol bisphosphate binding", "d": ["Binding to phosphatidylinositol bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48223", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA <=> (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43498", "l": "H(+) + keto-D-fructuronate + NADH => L-gulonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004366", "l": "glycerol-3-phosphate O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38495", "l": "a triacylglycerol + H2O = a 1,3-diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408542", "l": "GSSeSG is reduced to GSSeH and GSH by GSR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68384", "l": "(2E,6E)-farnesyl diphosphate + L-tryptophyl-[protein] = (2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63378", "l": "an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57852", "l": "a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391941", "l": "BLT receptors can bind LTB4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0009486", "l": "cytochrome bo3 ubiquinol oxidase activity", "d": ["Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140819", "l": "UDP-beta-L-arabinofuranose transporter activity", "d": ["Enables the transfer of UDP-beta-L-arabinofuranose from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380201", "l": "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006422", "l": "IFNG gene expression is stimulated by RUNX1 and inhibited by FOXP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14816", "l": "L-2-aminohexano-6-lactam <=> D-2-aminohexano-6-lactam", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72387", "l": "2 hydrogencarbonate(out) + sulfate(in) = 2 hydrogencarbonate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18926", "l": "L-gulono-1,4-lactone + NADP(+) => D-glucurono-3,6-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70637", "l": "2''-O-octanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-octanoyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661188", "l": "Defective SLCO2A1 does not transport PGT substrates from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47354", "l": "an aliphatic alcohol + H(+) + hexanoate => a hexanoate ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.195", "l": "\"N-hydroxythioamide S-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59639", "l": "D-xylotriose + O2 <=> D-xylotriono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29456", "l": "D-serine(in) => D-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627350", "l": "SMAC (DIABLO) binds XIAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74302", "l": "D-isoleucine(out) + D-serine(in) <=> D-isoleucine(in) + D-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42045", "l": "GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E)) => GDP + globoside Globo-H (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034531", "l": "2-hydroxy-4-hydroxymethylbenzalpyruvate hydratase-aldolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-4-hydroxymethylbenzalpyruvate + H2O = pyruvate + 4-hydroxymethylsalicylaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11948", "l": "4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.23", "l": "\"4-hydroxybenzoyl-CoA thioesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69851", "l": "a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21047", "l": "24-methylidenelophenol + S-adenosyl-L-methionine <=> (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800816", "l": "TP53 or TP63 stimulates PERP gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69136", "l": "2 H2O + 2 O2 + spermine = 2 H2O2 + 2 NH4(+) + spermine dialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809254", "l": "MTMR8 binds MTMR9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8963851", "l": "VD3 dissociates from GC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9633008", "l": "p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43439", "l": "coproporphyrinogen III + 3 O2 <=> coproporphyrin III + 3 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16639", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28350", "l": "UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose", "d": []}, {"i": "EC:5.4.99.30", "l": "\"UDP-arabinopyranose mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11066", "l": "beta-D-fructose 6-phosphate + phosphate => beta-D-fructose 1,6-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10949", "l": "ATP + D-glucosamine => ADP + D-glucosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58238", "l": "H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] => L-tyrosyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5606996", "l": "Soluble PROCR binds activated protein C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41819", "l": "ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GD2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72170", "l": "2 Na(+)(out) + taurohyodeoxycholate(out) <=> 2 Na(+)(in) + taurohyodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001730", "l": "2'-5'-oligoadenylate synthetase activity", "d": ["Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45752", "l": "(3E)-decenoyl-CoA = (2E)-decenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.16", "l": "\"glucosinolate gamma-glutamyl hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69450", "l": "delta-cadinol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876472", "l": "NPC2 binds CHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16951", "l": "H(+) + NADH + scyllo-inosose => myo-inositol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19254", "l": "a sphingomyelin + H2O => an N-acylsphing-4-enine + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0005247", "l": "voltage-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}, {"i": "REACT:R-HSA-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018747", "l": "RHOQ GEFs activate RHOQ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937856", "l": "p-Y-YAP1 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24513", "l": "L-serine + pyrazole => 3-(pyrazol-1-yl)-L-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102739", "l": "(gibberellin-36), 2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A36 + O2 + 2-oxoglutarate <=> H+ + gibberellin A4 + succinate + 2 carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62762", "l": "4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18282", "l": "NAD(+) + succinate => fumarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64610", "l": "diphosphate + uridylyl-L-threonyl-[protein] => L-threonyl-[protein] + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10553", "l": "D-glucose + O2 => 2-dehydro-D-glucose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38780", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69910", "l": "2 Na(+)(out) + uridine(out) <=> 2 Na(+)(in) + uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31881", "l": "beta-seco-amyrin => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35123", "l": "H(+)(out) + L-alanyl-D-glutamate(out) = H(+)(in) + L-alanyl-D-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67934", "l": "ADP + desmosterol(out) + H(+) + phosphate => ATP + desmosterol(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42163", "l": "(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 <=> (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426155", "l": "SREBP1A,2 binds the DHCR7 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24729", "l": "N-demethylindolmycin + S-adenosyl-L-methionine <=> H(+) + indolmycin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10987", "l": "(S)-lactate + oxaloacetate <=> (S)-malate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102182", "l": "4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol dehydrogenase/C4-decarboxylase activity", "d": ["Catalysis of the reaction: 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD <=> avenastenone + NADH + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68768", "l": "4 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022F + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42953", "l": "cytidine(49) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18957", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.53", "l": "\"(R)-limonene 6-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68791", "l": "(2Z,6Z)-farnesyl diphosphate <=> (Z)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65910", "l": "H2O + L-alanine + xanthurenate => 3-hydroxy-L-kynurenine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847977", "l": "FRK phosphorylates PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66338", "l": "L-glutamate(in) => L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62419", "l": "(E)-4-coumaroyl-CoA + H2O <=> 4-hydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49953", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate => 5,10-dihydrophenazine 1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362437", "l": "C-terminal Hh fragments are bound by lectins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3076905", "l": "Extracellular BTD hydrolyses BCTN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37324", "l": "glycyl-L-methionine + H2O => glycine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58515", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71429", "l": "3,3'-diiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out) => 3,3'-diiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013006", "l": "RHOA:GTP translocates to the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.117", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5220959", "l": "TDG excises 5-formylcytosine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61708", "l": "holo-[peptidyl-carrier protein] + L-seryl-5'-AMP = AMP + L-seryl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46538", "l": "a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093327", "l": "EPHA binds TIAM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021935", "l": "SST gene expression is stimulated by MECP2 and CREB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59583", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester <=> CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66681", "l": "ATP + coproporphyrinogen III(in) + H2O => ADP + coproporphyrinogen III(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625101", "l": "FOXO1 and SIN3A:HDAC complex bind GCK gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10130", "l": "all-trans-neoxanthin => all-trans-violaxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65857", "l": "A + a 1-hydroxy-3-oxo steroid => a steroid 1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59415", "l": "2-oxosuccinamate + H2O <=> NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27832", "l": "beta-phellandrene + diphosphate => neryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61199", "l": "(E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6795290", "l": "TORC2 complex phosphorylates SGK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788623", "l": "p-Y-STATs translocate to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103101", "l": "UDP-glucose:7-methylthioheptylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 7-methylthioheptylhydroximate <=> H+ + 6-methylthiohexyldesulfoglucosinolate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106268", "l": "3,5-dichloro-THPH methyl transferase activity", "d": ["Catalysis of the reaction: (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine = 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H+ + S-adenosyl-L-homocysteine."]}, {"i": "RHEA:48396", "l": "(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine = 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2509838", "l": "ITPA hydrolyses dITP to dIMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43216", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine = (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211224", "l": "Association of DFF40 with DFF45 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53875", "l": "CTP + D-ribose 5-phosphate + H(+) <=> CDP-D-ribose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2265534", "l": "Defective GLB1 does not hydrolyse a glycosaminoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951676", "l": "RUNX3 binds TEADs and YAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855648", "l": "SALM3 binds LAR-RPTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32658", "l": "a carboxylate + eugenol + NADP(+) <=> a coniferyl ester + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47650", "l": "phosphate + ribitol => D-ribitol 5-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22322", "l": "D-maltose + 2 phosphate => 2 alpha-D-glucose 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48474", "l": "ganglioside GD1a + N-acetylneuraminate => ganglioside GT1a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35400", "l": "1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine => beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34852", "l": "(3S)-3-hydroxyadipyl-CoA + NAD(+) => 3-oxoadipyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0050145", "l": "nucleoside monophosphate kinase activity", "d": ["Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158849", "l": "Phenol can form a sulfate conjugate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38103", "l": "L-galactonate = 2-dehydro-3-deoxy-L-galactonate + H2O", "d": []}, {"i": "EC:4.2.1.146", "l": "\"L-galactonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.46", "l": "\"6-aminohexanoate-oligomer exohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30825", "l": "H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20669", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46092", "l": "(25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0042802", "l": "identical protein binding", "d": ["Binding to an identical protein or proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24879", "l": "A + L-sorbopyranose => 1-dehydro-L-sorbose + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38642", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.111", "l": "\"mycocerosate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69092", "l": "H2O + NAD(+) + pentanal = 2 H(+) + NADH + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371590", "l": "HSP70 binds to HSP40:nascent protein (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34136", "l": "cannabigerolate + O2 => Delta(9)-tetrahydrocannabinolate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41488", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45895", "l": "an N-acylsphing-4-enine + CDP-ethanolamine <=> an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12018", "l": "(-)-germacrene D + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814555", "l": "Integrator complex processes the 3' end of snRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75370", "l": "cytidine(in) <=> cytidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62858", "l": "GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32182", "l": "(S)-2,3-dihydrodipicolinate + NAD(+) <=> dipicolinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45156", "l": "3-oxopropanoyl-CoA + H2O = 3-oxopropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9732729", "l": "Activated JAK1 binds RAF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445705", "l": "Release Of ADP From Myosin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799097", "l": "ATM phosphorylates ZNF420 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30447", "l": "3-methylxanthine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63656", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061522", "l": "1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity", "d": ["Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0001595", "l": "angiotensin receptor activity", "d": ["Combining with angiotensin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10451", "l": "2-oxoglutarate + a flavanone + O2 <=> a flavone + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25902", "l": "beta-D-fructose 6-phosphate => D-arabino-hex-3-ulose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60967", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose <=> (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853911", "l": "VENTX stimulates TP53 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26532", "l": "(2E)-butenoyl-CoA + H2O => 4-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65065", "l": "dimethylallyl diphosphate + siccayne => diphosphate + pestalodiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035379", "l": "carbon dioxide transmembrane transporter activity", "d": ["Enables the transfer of carbon dioxide (CO2) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63006", "l": "(11Z,14Z)-eicosadienoate + NH4(+) => (11Z,14Z)-eicosadienamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870628", "l": "Phosphorylated FOXO3 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19280", "l": "ATP + L-pyrrolysine + tRNA(Pyl) <=> AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68597", "l": "(2E,6E)-farnesyl diphosphate => beta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60224", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate", "d": []}, {"i": "EC:1.14.11.68", "l": "\"[histone H3]-trimethyl-L-lysine(27) demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174058", "l": "Degradation of multiubiquitinated Cdh1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15196", "l": "dGTP + H2O <=> 2'-deoxyguanosine + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52999", "l": "[eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH <=> [eIF5A protein]-deoxyhypusine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25813", "l": "H2O + N(1)-acetylspermidine + O2 => 3-acetamidopropanal + H2O2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25915", "l": "A + H2O + quinolin-5-ol <=> 5-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928631", "l": "GIT1 binds bPIX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74912", "l": "a (2E)-enoyl fatty acid + ATP + holo-[ACP] => a (2E)-enoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29860", "l": "5'-deoxyadenosine + H2O => 5-deoxy-D-ribose + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626038", "l": "EEF1A1 binds GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43062", "l": "beta-D-glucose 1-phosphate + glycerol => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11783", "l": "3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58245", "l": "H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] => ADP-D-ribose + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-517705", "l": "p-S318,221-HuR binds mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40534", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218824", "l": "p-6Y-VEGFR2 binds FYN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-984671", "l": "Chromokinesins form dimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853745", "l": "RET binds GFRA1,GFRA3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55527", "l": "H(+) + H2O + L-dopa + O2 <=> 3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48384", "l": "a 2,3-saturated fatty acid + H2O2 = a 3-hydroxy fatty acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467794", "l": "Resolution of sister chromatids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32870", "l": "myo-inositol(out) <=> myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25228", "l": "L-arabinitol + NAD(+) <=> H(+) + L-arabinose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099619", "l": "UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373748", "l": "SEMA4D interacts with CD72 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43211", "l": "5-(carboxymethyl)uridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48674", "l": "20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44709", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45292", "l": "2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110219", "l": "Cleavage of thymine by TDG glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847880", "l": "CYTH proteins bind ARF1:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63817", "l": "ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine => AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004420", "l": "hydroxymethylglutaryl-CoA reductase (NADPH) activity", "d": ["Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647994", "l": "RAS proteins are depalmitoylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170149", "l": "Translocation of active Cdc25C to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983156", "l": "Polyubiquitination of substrate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52153", "l": "(Z)-2-(indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose => (Z)-indolylmethyl desulfoglucosinolate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204824", "l": "Interaction of Tie2 and Ang4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49022", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide => 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340124", "l": "CSN polymer binds CaPO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53851", "l": "NAD(+) + taurocholate <=> 7-oxo-taurodeoxycholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24188", "l": "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) = 1,2-dihydroxydibenzothiophene + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.60", "l": "\"dibenzothiophene dihydrodiol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44637", "l": "2,4-dinitroanisole + H2O => 2,4-dinitrophenol + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13938", "l": "4-sulfobenzoate + NADH + O2 => 3,4-dihydroxybenzoate + NAD(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67688", "l": "2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O = 2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9676257", "l": "Formation of the SET1A complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-879459", "l": "F-actin capping protein is a heterodimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50490", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24913", "l": "L,L-cystathionine <=> 2-aminobut-2-enoate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29416", "l": "(S)-lactate(in) + H(+)(in) => (S)-lactate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37664", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869568", "l": "NPM1 binds TFAP2A homodimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52374", "l": "17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => 17beta-estradiol + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804596", "l": "APAF1:CYCS binds APIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35073", "l": "4-methylphenol(out) => 4-methylphenol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.99", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043909", "l": "N-acetylcitrulline deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-L-citrulline + H2O = citrulline + acetate."]}, {"i": "RHEA:61092", "l": "H2O + N(2)-acetyl-L-citrulline = acetate + L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56800", "l": "apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide = cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46665", "l": "corticosterone + H(+) + NADPH => 5beta-dihydrocorticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943279", "l": "GGT dimers hydrolyse GSH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645535", "l": "ALPK1 phosphorylates TIFA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14834", "l": "(R)-mevalonate + CoA + 2 NAD(+) => (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691150", "l": "TFR2 dimer binds 2xholoTF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9704248", "l": "CHRM4 binds CHRM4 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047411", "l": "2-(acetamidomethylene)succinate hydrolase activity", "d": ["Catalysis of the reaction: 2 H2O + 2-(acetamidomethylene)succinate = CO2 + NH3 + succinate semialdehyde + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196017", "l": "Dynamin is recruited to the gap junction plaque (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23688", "l": "adenine + H(+) + H2O = hypoxanthine + NH4(+)", "d": []}, {"i": "EC:3.5.4.2", "l": "\"adenine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014454", "l": "RHOG translocates to the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71792", "l": "(R)-lactate(in) + H(+)(in) => (R)-lactate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167288", "l": "TFIIS-mediated recovery of HIV-1 elongation from arrest (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.7", "l": "\"mannokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31370", "l": "2 H(+) + 3 nitrite <=> H2O + nitrate + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73118", "l": "quercetin + S-adenosyl-L-methionine <=> H(+) + rhamnetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.21", "l": "\"aspartate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854303", "l": "TBC1D11 binds RAB6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035538", "l": "carbohydrate response element binding", "d": ["Binding to a carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878117", "l": "RUNX3 binds ZFHX3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17985", "l": "4-(trimethylamino)butanal + H2O + NAD(+) = 4-(trimethylamino)butanoate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.47", "l": "\"4-trimethylammoniobutyraldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59354", "l": "H2O2 + lactobiono-1,5-lactone => beta-lactose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682598", "l": "ATM phosphorylates HERC2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2173323", "l": "Cleavage of C3 by fluid-phase C3i:factor B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57324", "l": "acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] = CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018701", "l": "2,5-dichlorohydroquinone reductive dehalogenase activity", "d": ["Catalysis of the reaction: organohalide + 2 H+ + 2 e- = R-H + HCl. Reactants include chlorohydroquinone (forms hydroquinone) and 2,5-dichlorohydroquinone (forms chlorohydroquinone)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40640", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O => (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23828", "l": "2-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.274", "l": "\"2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36926", "l": "(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606288", "l": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75454", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791235", "l": "GADD45A binds AURKA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674022", "l": "BRAP autoubiquitinates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873927", "l": "Release of STAT1 dimer from active receptor unit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.27", "l": "\"uracil-DNA glycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39535", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA = (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784734", "l": "PCSK9 binds LDLR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193668", "l": "p75NTR and RHOA-GDI interact (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047674", "l": "apiose 1-reductase activity", "d": ["Catalysis of the reaction: D-apiitol + NAD+ = D-apiose + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199518", "l": "C3d-complexed antigen binds to complement receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24223", "l": "beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase] <=> (4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29507", "l": "(2E,6E)-farnesyl diphosphate = (-)-alpha-gurjunene + diphosphate", "d": []}, {"i": "EC:4.2.3.72", "l": "\"alpha-gurjunene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658092", "l": "SIAH1, SIAH2 bind SNCAIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22130", "l": "(1S,4S)-camphor + H(+) + NADH => (1S,2R,4S)-borneol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24679", "l": "5,6,7,8-tetrahydromethanopterin + formaldehyde => 5,10-methylenetetrahydromethanopterin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64303", "l": "3-phenylpropylamine + pyruvate <=> 3-phenylpropanal + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45067", "l": "H2O + N-hexadecanoylethanolamine <=> ethanolamine + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14068", "l": "scyllo-inosose <=> 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20891", "l": "3-hydroxy-2-methylpropanoyl-CoA + H2O <=> 3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.350", "l": "\"menaquinone C(8)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20283", "l": "(Z)-glucotropeolin + adenosine 3',5'-bisphosphate + H(+) => (Z)-desulfoglucotropeolin + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53612", "l": "CTP + D-ribulose 5-phosphate + H(+) = CDP-D-ribulose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22330", "l": "diphosphate + thiamine phosphate => 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61064", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39959", "l": "1-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17833", "l": "3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.97", "l": "\"3-hydroxyanthranilate 4-C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196929", "l": "FLAD1 phosphorylates FMN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18892", "l": "D-glucose 6-phosphate + UDP-alpha-D-glucose <=> alpha,alpha-trehalose 6-phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62175", "l": "an N-acylethanolamine phosphate + H2O <=> an N-acylethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62820", "l": "1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75079", "l": "Formation of AT-AC C complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61545", "l": "ent-kaur-16-en-19-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48978", "l": "CO2 + H2O + NAD(+) + pyocyanin => 5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696605", "l": "USP12, USP26 deubiquitinate AR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57740", "l": "a 2,3-saturated meromycolyl-[ACP] + NAD(+) = a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.118", "l": "\"meromycolic acid enoyl-[acyl-carrier-protein] reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43328", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17058", "l": "a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44496", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine = 2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40147", "l": "eicosanoyl-CoA + H2O = CoA + eicosanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018768", "l": "RHOU auto-activates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65476", "l": "1-propanol + butanoyl-CoA = CoA + propyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050202", "l": "octopamine dehydratase activity", "d": ["Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444171", "l": "Receptor FFAR2 binds carboxylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39193", "l": "docosanoyl-CoA + NADP(+) => (2E)-docosenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58059", "l": "hypotaurine + pyruvate <=> 2-sulfinoacetaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987043", "l": "IL22RA1 binds JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3341294", "l": "Superoxide reduces cytochrome c (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392752", "l": "Phosphorylation of L1 by CK-II (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14842", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68624", "l": "phycoerythrobilin-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit]", "d": []}, {"i": "EC:4.4.1.39", "l": "\"C-phycoerythrin alpha-cysteine-82 phycoerythrobilin lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34692", "l": "(R)-lactoyl-CoA => acryloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445700", "l": "Myosin Binds ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71573", "l": "5-aminoethoxy-methyl-dUMP in DNA + CO2 => 5-O-(L-seryl)-dTMP in DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56517", "l": "Fe-coproporphyrin III + 2 H(+) + 2 H2O2 => 2 CO2 + 4 H2O + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52271", "l": "3-(aminomethyl)indole + S-adenosyl-L-methionine <=> (1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018787", "l": "4-chlorobenzoyl-CoA dehalogenase activity", "d": ["Catalysis of the reaction: 4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58754", "l": "1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134953", "l": "DHX36 or DHX9 binds MyD88 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19033", "l": "an N-acyl-D-glucosamine = an N-acyl-D-mannosamine", "d": []}, {"i": "EC:5.1.3.8", "l": "\"N-acylglucosamine 2-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018633", "l": "dimethyl sulfide monooxygenase activity", "d": ["Catalysis of the reaction: dimethyl sulfide + NADH + O2 = NAD+ + OH- + methanethiol + formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71616", "l": "(S)-malate(in) + sulfate(out) => (S)-malate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10386", "l": "beta-cyclopiazonate + diphosphate => cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5444523", "l": "Formation of MSH1:PMS2 Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16771", "l": "(2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784959", "l": "BPHL hydrolyses VACV to ACV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22563", "l": "(3R)-vestitone + NADP(+) <=> 2'-hydroxyformononetin + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166726", "l": "Activation of MASPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37470", "l": "1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) <=> 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42081", "l": "all-trans-retinal + H2O + NAD(+) => all-trans-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53528", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51102", "l": "16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390145", "l": "Phosphorylated HPO dimer phosphorylates SAV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11090", "l": "2 H(+) + triphosphate => H2O + trimetaphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42047", "l": "GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E)) <=> GDP + globoside Globo-H (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52991", "l": "[deoxyhypusine synthase]-L-lysine + dehydrospermidine <=> [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39334", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH <=> (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32423", "l": "(1R,4R)-dihydrocarvone + A = (R)-carvone + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29309", "l": "FMN + formaldehyde + 2 H(+) + H2O + sulfite => FMNH2 + methanesulfonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0005315", "l": "inorganic phosphate transmembrane transporter activity", "d": ["Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1222376", "l": "NOX2 generates superoxide from oxygen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804253", "l": "MDM2 ubiquitinates JMY (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15944", "l": "H2O + N(2)-acetyl-L-ornithine <=> acetate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38348", "l": "(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate => 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67766", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016689", "l": "manganese peroxidase activity", "d": ["Catalysis of the reaction: 2 Mn2+ + 2 H+ + hydrogen peroxide = 2 Mn3+ + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9617595", "l": "SGTA binds mislocalized membrane protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45129", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66850", "l": "2 Cu(+) + H(+) + NAD(+) => 2 Cu(2+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50298", "l": "2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23587", "l": "7,8-dihydropteroate + ATP + L-glutamate <=> 7,8-dihydrofolate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47106", "l": "5,6,7,8-tetrahydromethanopterin + L-serine => 5,10-methylenetetrahydromethanopterin + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46482", "l": "4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65762", "l": "a 17alpha-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62691", "l": "4 norrubrofusarin + O2 <=> 2 H2O + 2 ustilaginoidin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32288", "l": "(2R,3S)-3-isopropylmalate => (2S)-2-isopropylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65441", "l": "a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010341", "l": "gibberellin carboxyl-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a gibberellin = S-adenosyl-L-homocysteine + a gibberellin methyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29295", "l": "aldehydo-D-galacturonate(out) + H(+)(out) = aldehydo-D-galacturonate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.157", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322422", "l": "Beta-catenin recruits SMARCA4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73577", "l": "CAD hexamer transforms L-Gln to CAP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12389", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38426", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27644", "l": "adenine + alpha-D-ribose 1-phosphate => adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37619", "l": "(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60507", "l": "1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23289", "l": "acetaldehyde + CoA + NAD(+) => acetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190260", "l": "FGFR2b binds to FGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74343", "l": "O-hexanoyl-(R)-carnitine(in) = O-hexanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16154", "l": "an aliphatic amine + H2O + O2 => an aldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57513", "l": "chlorobenzene + H(+) + NADH + O2 => (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16156", "l": "an aliphatic amine + H2O + O2 <=> an aldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371435", "l": "Constitutive phosphorylation by GSK3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70475", "l": "2 S-adenosyl-L-methionine + sphing-4-enine = 2 H(+) + N,N-dimethylsphing-4-enine + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53091", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683925", "l": "ULK1 is dephosphorylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37758", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0017153", "l": "sodium:dicarboxylate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12435", "l": "L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine <=> H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0043139", "l": "5'-3' DNA helicase activity", "d": ["Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034833", "l": "geranylate CoA-transferase activity", "d": ["Catalysis of the reaction: geranylate + CoASH = trans-geranyl-CoA + OH-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932765", "l": "NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14474", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) => a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13722", "l": "H2O + testololactone => H(+) + testolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57864", "l": "indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.165", "l": "\"indole-3-carbonyl nitrile 4-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71945", "l": "(S)-malate(in) + 3 Na(+)(in) => (S)-malate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57298", "l": "a 2'-deoxyguanosine in DNA + glycolate + H(+) => an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047177", "l": "glycerophospholipid arachidonoyl-transferase (CoA-independent) activity", "d": ["Catalysis of the reaction: 1-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphoethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68035", "l": "(S)-cystathionine ketimine + 2 H(+) + NADH <=> (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113442", "l": "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74597", "l": "mesaconate + NH4(+) => (2S,3R)-3-methyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48920", "l": "ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.7.14", "l": "\"3,8-divinyl chlorophyllide a reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39237", "l": "(2E)-triacontenoyl-CoA + H2O => (3R)-hydroxytriacontanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28992", "l": "N-acetylneuraminate(in) => N-acetylneuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070635", "l": "nicotinamide riboside hydrolase activity", "d": ["Catalysis of the reaction: nicotinamide riboside + H2O = nicotinamide + D-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37501", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043726", "l": "5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity", "d": ["Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40427", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109813", "l": "GRB2-1 binds SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661230", "l": "MT1A binds arsenic (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38510", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617815", "l": "BBSome binds RAB3IP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.8.-.-", "l": "\"Nitrogen-oxygen lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67640", "l": "ATP + dZMP = ADP + dZDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869580", "l": "DEK binds TFAP2A homodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17211", "l": "2-formylglutarate + NH4(+) => 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205262", "l": "Direct recruitment of PI3K to p-KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35879", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444691", "l": "Prokineticin receptors bind prokineticin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3785768", "l": "MRN complex binds DNA double strand breaks (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31847", "l": "(S)-2,3-epoxysqualene = shionone", "d": []}, {"i": "EC:5.4.99.46", "l": "\"shionone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062203", "l": "Viteagnusin D synthase activity", "d": ["Catalysis of the reaction: H2O + peregrinol diphosphate = diphosphate + viteagnusin D."]}, {"i": "RHEA:62180", "l": "H2O + peregrinol diphosphate = diphosphate + viteagnusin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.6", "l": "\"vesicle-fusing ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2484822", "l": "Kinetochore assembly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62344", "l": "6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate = diphosphate + notoamide S", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55621", "l": "a carotenoid psi-end group => a carotenoid beta-end derivative", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868071", "l": "Clathrin recruits PIK3C2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53791", "l": "allodeoxycholoyl-CoA + beta-muricholate <=> allodeoxycholate + beta-muricholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52049", "l": "9-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176175", "l": "Stalling of DNA replication fork and RPA binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38002", "l": "2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine <=> H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16946", "l": "(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.945916858897462", "identifiers": [{"i": "GO:0098631", "l": "cell adhesion mediator activity", "d": ["The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617486", "l": "HOXB2 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797554", "l": "ABP1 binds SHANK proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32762", "l": "L-lysine <=> (3R)-3-methyl-D-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868071", "l": "Clathrin recruits PIK3C2A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63187", "l": "NADH + 2 O2 <=> H(+) + NAD(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851908", "l": "Activated MET binds GAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9671145", "l": "DKC1 binds SHQ1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653974", "l": "Ragulator binds Rag dimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605591", "l": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39321", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31132", "l": "5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide => (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694419", "l": "SARS-CoV-2 gRNA complement (minus strand):RTC binds RTC inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21502", "l": "H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose => UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371422", "l": "ATP hydrolysis by HSP70 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109702", "l": "PDPK1 phosphorylates AKT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51024", "l": "H(+) + NADH + O2 + toluene-4-sulfonate = 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814831", "l": "TBC1D20 binds RAB1:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73582", "l": "(E,E)-piperoyl-AMP + CoA <=> (E,E)-piperoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35178", "l": "novobiocin(in) <=> novobiocin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692437", "l": "ANG binds F-actin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047361", "l": "phosphomannan mannosephosphotransferase activity", "d": ["Catalysis of the reaction: phosphomannan(n) + GDP-mannose = phosphomannan(n+1) + GMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71668", "l": "malonate(out) + succinate(in) => malonate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781941", "l": "WNTs are secreted in exosomes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937613", "l": "CRHBP binds CRH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19877", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.67", "l": "\"1-phosphatidylinositol 4-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57426", "l": "catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => guaiacol + O2 + reduced [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31498", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938887", "l": "PML binds RUNX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432956", "l": "BP230 is recruited to the hemidesmosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29982", "l": "2'-deoxyadenosine(in) + H(+)(in) <=> 2'-deoxyadenosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005043", "l": "netrin receptor activity involved in chemorepulsion", "d": ["Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671747", "l": "Phosphorylated LEPR Binds SHP2 (PTPN11) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62994", "l": "NH4(+) + tetradecanoate => H2O + tetradecamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879221", "l": "PSTPIP1 binds Pyrin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3159232", "l": "Recruitment Of HIV Virion Budding Machinery (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77081", "l": "Formation of the CE:GMP intermediate complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212380", "l": "Formation of TRAP coactivator complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58866", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51360", "l": "H2O + N-(9Z-octadecenoyl)-L-leucine = (9Z)-octadecenoate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396009", "l": "STING binds c-di-GMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67740", "l": "N-acetyl-beta-neuraminate = aceneuramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63522", "l": "3-isopropylcatechol + H2O + NAD(+) => 2-isopropylphenol + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031686", "l": "A1 adenosine receptor binding", "d": ["Binding to an A1 adenosine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671702", "l": "AP1G2 binds HGS and CHMP2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28364", "l": "dGMP + diphosphate + H(+) => dGTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20427", "l": "(S)-oxalosuccinate + ADP + H(+) + phosphate => 2-oxoglutarate + ATP + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382553", "l": "ABCA7:Apo1A-mediated phospholipid efflux (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44214", "l": "3-hydroxytetradecanoyl-CoA + AMP + diphosphate => 3-hydroxytetradecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73872", "l": "(R)-noradrenaline(out) => (R)-noradrenaline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.116918913335823", "identifiers": [{"i": "GO:0016780", "l": "phosphotransferase activity, for other substituted phosphate groups", "d": ["Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917700", "l": "MVB Vesicle Formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.-", "l": "\"Acting on ATP; involved in cellular and subcellular movement\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209181", "l": "ARM displaces GRO and binds to PAN which activates transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465924", "l": "OPN1LW binds 11cRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26272", "l": "Co-precorrin-2 + 3 H(+) <=> Co(2+) + precorrin-2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781814", "l": "USP19 deubiquitinates RNF123 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41099", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30932", "l": "L-cysteine + O-acetyl-L-homoserine => acetate + H(+) + L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24262", "l": "2-oxopent-4-enoate + CO2 => (3E)-2-oxohex-3-enedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051922", "l": "cholesterol sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate + H+."]}, {"i": "RHEA:52368", "l": "3'-phosphoadenylyl sulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52417", "l": "3-dehydro-4-O-phospho-D-erythronate + H(+) => CO2 + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.117", "l": "\"aflatoxin B synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212432", "l": "Formation of DRIP coactivator complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793472", "l": "RIPK3 binds p-S9-PRKN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71236", "l": "[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] => [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40680", "l": "(9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate => 1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38987", "l": "nonanoyl-CoA + O2 = (2E)-nonenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54488", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9710959", "l": "p-STAT1 dimer binds KPNA1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37524", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17351", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate => (2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38134", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol <=> 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.30", "l": "\"D-arabinonolactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71213", "l": "chlorate(in) + 2 Na(+)(in) => chlorate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59296", "l": "an N-acylglycine + 2 L-ascorbate + O2 = an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49266", "l": "(E)-caffeate + H(+) + shikimate => 5-O-[(E)-caffeoyl]-shikimate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31598", "l": "(Z)-2-methylureidoacrylate + H2O <=> (Z)-2-methylaminoacrylate + carbamate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247837", "l": "WNT ligands traffic to the Golgi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050379", "l": "UDP-glucuronate 5'-epimerase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-L-iduronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39551", "l": "(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH = (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419426", "l": "Cannabinoid receptors can bind cannabinoids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53481", "l": "3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH => 5alpha-androstane-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109860", "l": "MAP2K1 phosphorylates MAPK3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75311", "l": "D-serine(in) + L-alanine(out) + Na(+)(out) = D-serine(out) + L-alanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042898", "l": "fosmidomycin transmembrane transporter activity", "d": ["Enables the transfer of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603208", "l": "Defective OPLAH does not hydrolyse OPRO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71292", "l": "(R)-carnitine(out) + chloride(out) + 2 Na(+)(out) => (R)-carnitine(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53628", "l": "(2E,6E)-farnesyl diphosphate = (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate", "d": []}, {"i": "EC:4.2.3.160", "l": "\"(2S,3R,6S,9S)-(-)-protoillud-7-ene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53805", "l": "allodeoxycholoyl-CoA + ursodeoxycholate => allodeoxycholate + ursodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39122", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 <=> (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016169", "l": "bacteriochlorophyll c binding", "d": ["Binding to bacteriochlorophyll c, a chlorophyll of photosynthetic bacteria, for example green sulfur bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29119", "l": "a ubiquinol + nitrate = a ubiquinone + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73621", "l": "CTP(in) + GTP(out) => CTP(out) + GTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34125", "l": "CoA + H(+) + olivetolate => 3,5,7-trioxododecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26229", "l": "3 NADP(+) + phytyl diphosphate = geranylgeranyl diphosphate + 3 H(+) + 3 NADPH", "d": []}, {"i": "EC:1.3.1.83", "l": "\"geranylgeranyl diphosphate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794475", "l": "Cipro:ALB dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809764", "l": "SBF1 binds MTMR2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73660", "l": "ADP(out) + ATP(in) + H(+)(out) + Mg(2+)(in) => ADP(in) + ATP(out) + H(+)(in) + Mg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63970", "l": "atromentin + 2 H2O => 2 3-(4-hydroxyphenyl)pyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37811", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18341", "l": "D-xylono-1,4-lactone + H2O = D-xylonate + H(+)", "d": []}, {"i": "EC:3.1.1.68", "l": "\"xylono-1,4-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36501", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH => 2-dehydro-3-deoxy-L-rhamnonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13356", "l": "4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol <=> 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71158", "l": "(E)-caffeoylpyruvate + H2O <=> (E)-caffeate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16247", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0052616", "l": "ent-kaur-16-en-19-ol oxidase activity", "d": ["Catalysis of the reaction: H+ + NADPH + ent-kaur-16-en-19-ol + oxygen = 2 H2O + NADP+ + ent-kaur-16-en-19-al."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30417", "l": "formate + H2O + heptadecane + 2 NADP(+) => H(+) + 2 NADPH + O2 + octadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033885", "l": "10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity", "d": ["Catalysis of the reaction: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803838", "l": "FGFR2c-specific alternative splicing produces FGFR2c transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34051", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H2O = 6'''-deamino-6'''-hydroxyneomycin C + acetate", "d": []}, {"i": "EC:3.5.1.113", "l": "\"2'''-acetyl-6'''-hydroxyneomycin C deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75363", "l": "thymidine(in) = thymidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371422", "l": "ATP hydrolysis by HSP70 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64811", "l": "acetyl-CoA + O-(2-aminoethyl)-L-serine <=> CoA + H(+) + O-(2-acetamidoethyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65614", "l": "a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001532", "l": "interleukin-21 receptor activity", "d": ["Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70003", "l": "6-oxocampestanol + O2 + reduced [NADPH--hemoprotein reductase] = cathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371554", "l": "HSF1 acetylation at Lys80 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73258", "l": "(2S)-sakuranetin + S-adenosyl-L-methionine <=> (2S)-naringenin 4',7-dimethyl ether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57729", "l": "H(+) + trans-aconitate => CO2 + itaconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46593", "l": "alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805546", "l": "Keratin type I binds keratin type II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.61", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655483", "l": "USP1 autocleavage (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032145", "l": "succinate-semialdehyde dehydrogenase binding", "d": ["Binding to succinate-semialdehyde dehydrogenase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41113", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788622", "l": "p-Y-STATs dimerize (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30664", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole => hapalindole H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111962", "l": "PDE4A,C,D hydrolyse cAMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51131", "l": "A + an aliphatic amine + H2O <=> AH2 + an aldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57025", "l": "apulose 4-phosphate + D-glyceraldehyde 3-phosphate => D-xylulose 5-phosphate + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60283", "l": "L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034878", "l": "2-hydroxyisonicotinate dehydrogenase activity", "d": ["Catalysis of the reaction: 2-hydroxyisonicotinate + acceptor + H2O = citrazinate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451283", "l": "kainate receptor binds glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.1.5", "l": "\"hydrogen dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45075", "l": "(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] <=> (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709406", "l": "CO binds to Cytochrome c oxidase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22339", "l": "glycine betaine + L-homocysteine <=> L-methionine + N,N-dimethylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20599", "l": "H(+) + L-cystine + NADH => 2 L-cysteine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36216", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863494", "l": "ASICs bind STOML3, (STOM) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696323", "l": "CNRs bind CNR agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23114", "l": "3-methylphenol + CO2 => 6-methylsalicylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050642", "l": "2-alpha-hydroxytaxane 2-O-benzoyltransferase activity", "d": ["Catalysis of the reaction: 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20535", "l": "phosphate + pyridoxal => H2O + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20703", "l": "ATP + lipid A disaccharide (E. coli) <=> ADP + H(+) + lipid IVA (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73549", "l": "GTP(in) + UTP(out) => GTP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.42903515889401", "identifiers": [{"i": "GO:0140299", "l": "small molecule sensor activity", "d": ["Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655240", "l": "Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30029", "l": "glycerol + NAD(+) => D-glyceraldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080150", "l": "S-adenosyl-L-methionine:benzoic acid carboxyl methyl transferase activity", "d": ["Catalysis of the reaction: benzoate + S-adenosyl-L-methionine = methylbenzoate + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102785", "l": "violaxanthin oxygenase activity", "d": ["Catalysis of the reaction: violaxanthin + 2 O2 = 2 5,6-epoxy-3-hydroxy-9-apo-beta-caroten-9-one + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73329", "l": "cimicifugate J + CoA => (2R,3S)-piscidate + (E)-sinapoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65088", "l": "asperaculane E + O2 + reduced [NADPH--hemoprotein reductase] = asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032867", "l": "L-arabinose:NADP reductase activity", "d": ["Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692761", "l": "JUN binds MAPK6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39727", "l": "a sphingomyelin(in) = a sphingomyelin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19643", "l": "(E)-4-coumaroyl-CoA + AMP + diphosphate => (E)-4-coumarate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009309", "l": "RUNX2 binds STUB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001162", "l": "RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding", "d": ["Binding to an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47859", "l": "ganglioside GD1a (d18:1(4E)) + H2O <=> ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9692867", "l": "HRH3 binds pitosilant (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070573", "l": "metallodipeptidase activity", "d": ["Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210277", "l": "Interaction of PECAM-1 and SHP-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74014", "l": "[(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + H(+) + NADPH + O2 <=> [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211239", "l": "SIRT1 deacetylates TAF1B in SL1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59870", "l": "4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+) => 4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32162", "l": "AH2 + epoxyqueuosine(34) in tRNA <=> A + H2O + queuosine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5606996", "l": "Soluble PROCR binds activated protein C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632182", "l": "PRMT1 methylates ESRs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013147", "l": "RAC1 GDIs block activation of RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9617595", "l": "SGTA binds mislocalized membrane protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13820", "l": "[protein]-disulfide + H2O + phylloquinone <=> 2,3-epoxyphylloquinone + [protein]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39757", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20397", "l": "L-cysteine + O-succinyl-L-homoserine = H(+) + L,L-cystathionine + succinate", "d": []}, {"i": "EC:2.5.1.48", "l": "\"cystathionine gamma-synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49415", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose <=> alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853444", "l": "AURKA phosphorylates PHLDA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607734", "l": "PKC-delta translocates to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56637", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38051", "l": "2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.242070417869868", "identifiers": [{"i": "GO:0016748", "l": "succinyltransferase activity", "d": ["Catalysis of the transfer of a succinyl (3-carboxypropanoyl) group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689111", "l": "PARK2 autoubiquitinates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73336", "l": "ATP + beta-alanine + tryptamine => AMP + beta-alanyl-tryptamine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9770145", "l": "Formation of the Spliceosomal Bact complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109813", "l": "GRB2-1 binds SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64024", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine) = H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222020", "l": "NUAK1 phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102614", "l": "germacrene A acid 8beta-hydroxylase activity", "d": ["Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-oate + NADPH + O2 + H+ <=> 8beta-hydroxy-germacra-1(10),4,11(13)-trien-12-oate + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120319", "l": "long-chain fatty acid omega-1 hydroxylase activity", "d": ["Catalysis of the reaction: an (omega-1)-ethyl long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase."]}, {"i": "RHEA:60936", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391934", "l": "DP2 receptor can bind PGD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5681980", "l": "ATG12 binds ATG7 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73239", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether = H(+) + ladanein + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0008989", "l": "rRNA (guanine-N1-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25600", "l": "5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate <=> (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31501", "l": "a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP => a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17042", "l": "adenosine 5'-phosphosulfate + H2O => AMP + 2 H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51759", "l": "a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate <=> a 2-acyl-4,6-diprenylphloroglucinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332356", "l": "CAMK2 binds MAP3K7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44750", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) => 5-amino-1-(beta-D-ribosyl)imidazole + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58332", "l": "(E)-non-2-en-1-ol + NADP(+) = (E)-non-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14486", "l": "(2E,6E)-farnesyl diphosphate + H2O => 10-epi-juneol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36780", "l": "2-oxoglutarate + GDP-alpha-D-perosamine => GDP-4-dehydro-alpha-D-rhamnose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730856", "l": "Autophosphorylation of PAK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15888", "l": "NADP(+) + propane-1,2-diol <=> (S)-lactaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63309", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106379", "l": "8-oxo-(d)RTP hydrolase activity", "d": ["Catalysis of the reaction: 8-oxo-(d)RTP + H20 = 8-oxo-(d)RMP + diphosphate + H+."]}, {"i": "REACT:R-HSA-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76002", "l": "glutarate(in) + kynurenate(out) <=> glutarate(out) + kynurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18637", "l": "H2 + NADP(+) = H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75615", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate = ectocarpin B + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67559", "l": "3'-phosphoadenylyl sulfate + glycocholate <=> adenosine 3',5'-bisphosphate + glycocholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004059", "l": "aralkylamine N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21217", "l": "ATP + D-ribose 5-phosphate => ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20076", "l": "D-allothreonine <=> acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54445", "l": "a (2R,3S,4S)-leucoanthocyanidin + NADP(+) => a (2R,3R)-dihydroflavonol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568846", "l": "CDKN2A (p14-ARF) SUMOylates WRN with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71856", "l": "taurochenodeoxycholate(out) => taurochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14429", "l": "a [oligopeptide](in) + ATP + H2O = a [oligopeptide](out) + ADP + H(+) + phosphate", "d": []}, {"i": "EC:7.4.2.6", "l": "\"ABC-type oligopeptide transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0047623", "l": "adenosine-phosphate deaminase activity", "d": ["Catalysis of the reaction: an adenosine-phosphate + H20 = an inosine phosphate + NH3. Catalyzes the deamination of AMP, ADP or ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68181", "l": "a short-chain fatty acyl-CoA + H2O => a short-chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043786", "l": "cinnamate reductase activity", "d": ["Catalysis of the reaction: 3-phenylpropanoate + NAD+ = (E)-cinnamate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47839", "l": "[5-(aminomethyl)-3-furyl]methyl phosphate + ATP <=> [5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12727", "l": "H(+) + keto-D-sorbose + NADH => D-iditol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59541", "l": "(2R)-ethylmalonyl-CoA + H(+) => butanoyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013110", "l": "RHOC binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2464822", "l": "RDH12 reduces atRAL to atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70451", "l": "2-oxoglutarate + an N(1)-ethyl-2'-deoxyadenosine in single-stranded DNA + O2 = a 2'-deoxyadenosine in single-stranded DNA + acetaldehyde + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13193", "l": "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate", "d": []}, {"i": "EC:5.4.99.18", "l": "\"5-(carboxyamino)imidazole ribonucleotide mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084501", "l": "Collagen type VII binds collagen type IV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60317", "l": "N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61694", "l": "AMP + L-threonyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-threonyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69769", "l": "(E)-non-2-enoate + 2 H(+) + NADH => (E)-non-2-enal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55347", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol <=> 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809707", "l": "MTMR12 binds MTMR2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73077", "l": "H(+) + luteolin 7-methyl ether + S-adenosyl-L-homocysteine => luteolin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39437", "l": "(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+) => (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434650", "l": "MATEs mediate extrusion of xenobiotics (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39247", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA = (2E,11Z)-eicosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784765", "l": "p-Y705-STAT3 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34986", "l": "sulfate(in) <=> sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632668", "l": "SMO translocates to the cilium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689649", "l": "BAP1 binds BRCA1:BARD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13861", "l": "D-xylose + NAD(+) = D-xylono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18206", "l": "AH2 + O2 + progesterone => 11alpha-hydroxyprogesterone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43591", "l": "globoside NORint + UDP-alpha-D-galactose <=> globoside NOR2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65225", "l": "(1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+) => H(+) + NADPH + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102836", "l": "1-18:1-2-16:1-monogalactosyldiacylglyceroldesaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.16", "l": "\"vitamin D3 24-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42371", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23488", "l": "1,4-benzoquinone + H(+) + NADPH = hydroquinone + NADP(+)", "d": []}, {"i": "EC:1.6.5.6", "l": "\"p-benzoquinone reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52397", "l": "4-O-phospho-D-threonate + NAD(+) => CO2 + dihydroxyacetone phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43428", "l": "1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28663", "l": "H2O + melibiose = D-galactose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37649", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39670", "l": "a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> a ketone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46453", "l": "2 L-leucyl-tRNA(Leu) => cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888589", "l": "Release of GABA at the synapse (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373724", "l": "Nephrin binds NCK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48578", "l": "3-chloro-cis,cis-muconate + 2 H(+) => 4-chlorocatechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30931", "l": "L-cysteine + O-acetyl-L-homoserine = acetate + H(+) + L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38767", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000074", "l": "TCN2 binds RCbl in the circulation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62537", "l": "digoxigenin + 2 Fe(II)-[cytochrome c] + 3 H(+) => dihydrodigoxigenin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-451033", "l": "(S)-Malate <=> Fumarate + H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.033057138195133", "identifiers": [{"i": "GO:0003700", "l": "DNA-binding transcription factor activity", "d": ["A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons."]}]}
{"type": "biolink:MolecularActivity", "ic": "60.136453459673234", "identifiers": [{"i": "GO:0140098", "l": "catalytic activity, acting on RNA", "d": ["Catalytic activity that acts to modify RNA, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879909", "l": "Activation of STAT5a/b by JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30632", "l": "alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate => beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24226", "l": "4-methylcatechol + CO2 + NADPH => (1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47837", "l": "[5-(aminomethyl)-3-furyl]methyl phosphate + ATP => [5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626816", "l": "PIN1 binds p-S345-NCF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13484", "l": "ATP + L-methionine + tRNA(Met) <=> AMP + diphosphate + L-methionyl-tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20674", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71638", "l": "phosphate(in) + 2 thiosulfate(out) <=> phosphate(out) + 2 thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58962", "l": "benzoate + H(+) + H2O2 => benzaldehyde + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759129", "l": "NFE2L2 binds the PRDX1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74499", "l": "H(+) + NADPH + yaequinolone D = H2O + NADP(+) + penigequinolone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16386", "l": "4-hydroxybenzoate + 2 H(+) + NADPH + O2 => CO2 + H2O + hydroquinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47086", "l": "3-(4-hydroxyphenyl)pyruvate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450466", "l": "AUF1:mRNA complex is destroyed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373705", "l": "Caspase cleavage of DCC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51195", "l": "(R)-2-hydroxyglutarate + NADP(+) <=> 2-oxoglutarate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26525", "l": "(2S,3S)-2-methylcitrate <=> 2-methyl-trans-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73696", "l": "dADP(out) + H(+)(out) + phosphate(in) => dADP(in) + H(+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44932", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29189", "l": "fumarate + ubiquinol-8 => succinate + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31213", "l": "diphosphate + L-adenosylselenomethionine + phosphate => ATP + H2O + L-selenomethionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45358", "l": "(11Z)-eicosenoate + sphing-4-enine => H2O + N-(11Z-eicosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6795667", "l": "MDM2 translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50075", "l": "ATP + H2O + tauroursodeoxycholate(in) <=> ADP + H(+) + phosphate + tauroursodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18182", "l": "acetyl-CoA + glyoxylate + H2O => (S)-malate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20778", "l": "myo-inositol + stachyose => alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004307", "l": "ethanolaminephosphotransferase activity", "d": ["Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63808", "l": "ATP + citrate + spermidine = AMP + diphosphate + H(+) + N(8)-citryl-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40004", "l": "ent-copalyl diphosphate => (Z)-biformene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47063", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417843", "l": "P2Y13 binds ADP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54793", "l": "L-histidyl-[protein] + N(7)-methyl-GTP => diphosphate + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68986", "l": "a 5-methyl-2'-deoxycytidine in DNA + ADP + 2 H(+) + phosphate + S-adenosyl-L-homocysteine => a 2'-deoxycytidine in DNA + ATP + H2O + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102582", "l": "cyanidin 3-O-p-coumaroylglucoside 2-O''-xylosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + UDP-alpha-D-xylose <=> cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59413", "l": "2-oxosuccinamate + H2O => NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130627", "l": "MHC class II antigen internalization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9670014", "l": "Factor VIIIa dissociates  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29751", "l": "acetoacetate(in) = acetoacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52676", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine", "d": []}, {"i": "EC:3.5.1.132", "l": "\"[amino group carrier protein]-ornithine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14873", "l": "indole-3-ethanol + NAD(+) = H(+) + indole-3-acetaldehyde + NADH", "d": []}, {"i": "EC:1.1.1.190", "l": "\"indole-3-acetaldehyde reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353039", "l": "1,3-bisphosphoglycerate + ADP <=> 3-phosphoglycerate + ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40278", "l": "hexadecanedioyl-CoA + O2 <=> (2E)-hexadecenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429767", "l": "Passive I- efflux mediated by SMCT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74828", "l": "UDP-alpha-D-galacturonate(in) + UMP(out) => UDP-alpha-D-galacturonate(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57182", "l": "N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] => L-lysyl-[protein] + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40925", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40886", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) <=> (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57715", "l": "(E)-sinapaldehyde + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106334", "l": "3'-deoxyribose phosphate lyase activity", "d": ["Catalysis of the conversion of a 3'-deoxyribose phosphate in DNA to a 3'-phosphate."]}, {"i": "RHEA:65764", "l": "a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + H2O = (2E,4S)-4,5-dihydroxypent-2-enal + a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000074", "l": "TCN2 binds RCbl in the circulation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37953", "l": "(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856525", "l": "ANGPTL8 binds ANGPTL3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190519", "l": "Internalization of gap junction plaques (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69637", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75248", "l": "acetyl-CoA + N-terminal L-prolyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-prolyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67487", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41873", "l": "3-oxododecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxydodecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11414", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+) => 6-hydroxymethyl-7,8-dihydropterin + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17463", "l": "D-sedoheptulose 7-phosphate + phosphate => D-sedoheptulose 1,7-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14433", "l": "a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate", "d": []}, {"i": "EC:2.7.7.72", "l": "\"CCA tRNA nucleotidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017398", "l": "NOTCH3 coactivator complex binds HEYL gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029690", "l": "Caspase-6 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757256", "l": "MCM3 binds MCM5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170986", "l": "Ral-GDS binds to Ras-GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71258", "l": "3 Na(+)(out) + phosphate(out) <=> 3 Na(+)(in) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46068", "l": "(3E)-nonenoyl-CoA = (2E)-nonenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669240", "l": "FLNA binds PAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49554", "l": "H(+) + L-lysyl-[protein] + lactate => H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54713", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63873", "l": "2-oxoglutarate + L-isoleucine + O2 => 3(1)-hydroxy-L-isoleucine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26175", "l": "1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA <=> CoA + H(+) + mycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170979", "l": "(Frs2)C3G stimulates nucleotide exchange on Rap1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0016984", "l": "ribulose-bisphosphate carboxylase activity", "d": ["Catalysis of the reaction: 2 (2R)-3-phosphoglycerate + 2 H+ = CO2 + D-ribulose 1,5-bisphosphate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71922", "l": "3 Na(+)(out) + succinate(out) <=> 3 Na(+)(in) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167481", "l": "Abortive termination of HIV-1 elongation after arrest (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49566", "l": "2-epi-valiolone + phosphate => D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851908", "l": "Activated MET binds GAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442749", "l": "CaMKK autophosphorylates in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56864", "l": "12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)", "d": []}, {"i": "EC:2.3.1.281", "l": "\"coelimycin P1 polyketide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54366", "l": "acetoin => 2 acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33642", "l": "ATP + CoA + tetracosanoate <=> AMP + diphosphate + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168445", "l": "PTP1B binds the GH receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57598", "l": "(2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080072", "l": "spermidine:sinapoyl CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of a sinapoyl group to a nitrogen atom on the spermidine molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71228", "l": "2 Na(+)(out) + selenocyanate(out) => 2 Na(+)(in) + selenocyanate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59172", "l": "hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] = AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61170", "l": "H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP => quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58199", "l": "H2O + N(6)-acetyl-L-lysyl-[histone] <=> acetate + L-lysyl-[histone]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41280", "l": "H2O + N-octadecanoylsphing-4-enine => octadecanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14370", "l": "2-phosphoglycolate + H2O => glycolate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28713", "l": "H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out) => H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32570", "l": "(2E)-geranyl diphosphate <=> (1R,4S)-camphene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444171", "l": "Receptor FFAR2 binds carboxylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418850", "l": "Activation of Cdc42 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12826", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine => [thioredoxin]-dithiol + H(+) + phosphate + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67194", "l": "ADP + H(+) + N-11-cis-retinylidenephosphatidylethanolamine(in) + phosphate => ATP + H2O + N-11-cis-retinylidenephosphatidylethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24025", "l": "(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate => (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67714", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+) => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33805", "l": "2 H(+) + L-histidine + NADH => H2O + L-histidinal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18299", "l": "a primary amine + phthalate => a phtalamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24832", "l": "ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134822", "l": "DDX41 binds viral dsDNA  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24996", "l": "N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352268", "l": "Cleavage of Satb1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49754", "l": "CO2 + 2 H2O + NAD(+) + proviolacein => 2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429860", "l": "DCP1-DCP2 complex decaps mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209925", "l": "DIT and MIT combine to form triiodothyronine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75644", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16519", "l": "aminoacetone + H(+) + NADH => (R)-1-aminopropan-2-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47587", "l": "ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GT1c (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9718360", "l": "GNRHR binds GNRHR peptide agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8963734", "l": "IL9 binds IL9R:JAK1 and IL2RG:JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086083", "l": "SUMOylation of ING2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69104", "l": "2-oxo-3-sulfanylpropanoate + L-kynurenine = H2O + kynurenate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444433", "l": "Cho transports from the extracellular space to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3221843", "l": "MSR1 (SCARA1) binds collagen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32407", "l": "(1R,2S,4S)-neoisodihydrocarveol + NAD(+) = (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621410", "l": "HMGCR gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205238", "l": "SHP2 interacts with p-KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58074", "l": "a jasmonate + NADP(+) => a 4,5-didehydrojasmonate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781897", "l": "USP11 deubiquitinates NFKBIA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353318", "l": "Insertion of correct bases opposite to the lesion by Pol kappa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22979", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10435", "l": "2-(acetamidomethylene)succinate + H(+) + 2 H2O <=> acetate + CO2 + NH4(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68843", "l": "(2Z,6E)-farnesyl diphosphate <=> (6R,7S)-2,2,6-trimethyl-10-methylenebicyclo[5.4.0]undec-1(11)-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222128", "l": "NOC2L binds TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964284", "l": "BTK in active Gq-BTK complex is activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36350", "l": "N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine <=> 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013009", "l": "RHOA binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58601", "l": "2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726621", "l": "PGR binds PGR antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451463", "l": "pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23901", "l": "cis-stilbene oxide + H2O => (1R,2R)-hydrobenzoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54689", "l": "alliin => 2-aminoprop-2-enoate + allylsulfenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199014", "l": "CD96 binds PVR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12774", "l": "2-oxoglutarate + O2 + proclavaminate => CO2 + dihydroclavaminate + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36552", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol => 3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168136", "l": "Activated JNKs phosphorylate c-JUN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40577", "l": "CoA + glutarate + H(+) => glutaryl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56719", "l": "H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] <=> H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69173", "l": "Joining of adjacent Okazaki fragments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211206", "l": "Translocation of DFF to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373738", "l": "Neurofascin interacts with syntenin-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9716947", "l": "ESR1 binds ESR1 agonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38229", "l": "CoA + hexadecanyl (9Z)-octadecenoate => (9Z)-octadecenoyl-CoA + hexadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-445072", "l": "Interaction of PAK1 with Rac1-GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19474", "l": "4-hydroxybenzoate + H(+) + NADH + O2 => 3,4-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63425", "l": "(2S)-2-phospholactate + GTP + H(+) => (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13289", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP", "d": []}, {"i": "EC:2.7.8.15", "l": "\"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015019", "l": "heparan-alpha-glucosaminide N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32312", "l": "L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57184", "l": "L-cysteinyl-[protein] + methylglyoxal = S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25722", "l": "H(+) + N,N-dihydroxy-L-trihomomethionine <=> (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5612508", "l": "GLI3R binds the PTCH1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44986", "l": "CoA + O-3-methylbutanoyl-(R)-carnitine => (R)-carnitine + 3-methylbutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62133", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dTTP => a 2'-deoxyribonucleoside 5'-diphosphate + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69336", "l": "(E)-alk-1-en-1-SO-peroxol = (Z)-alkanethial oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53277", "l": "17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] => 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48169", "l": "H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine => N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10459", "l": "acetyl-CoA + D-maltose <=> 1-O-acetylmaltose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64278", "l": "chrysophanol + H2O => chrysophanol-9-anthrone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052624", "l": "2-phytyl-1,4-naphthoquinone methyltransferase activity", "d": ["Catalysis of the reaction: demethylphylloquinone + S-adenosyl-L-methionine = phylloquinone + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19803", "l": "3'-dephospho-CoA + diphosphate => (R)-4'-phosphopantetheine + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28962", "l": "D-xylose(in) + H(+)(in) <=> D-xylose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16277", "l": "H2O + indole-3-acetaldehyde + O2 = (indol-3-yl)acetate + H(+) + H2O2", "d": []}, {"i": "EC:1.2.3.7", "l": "\"indole-3-acetaldehyde oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694304", "l": "nsp14 binds nsp12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29827", "l": "Mg(2+)(in) = Mg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203553", "l": "eNOS binds NOSIP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74722", "l": "myricetin + S-adenosyl-L-methionine <=> 7-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18392", "l": "alpha-D-xylose 1-phosphate + H(+) + UTP <=> diphosphate + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871260", "l": "YAP1 binds TEAD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71407", "l": "7beta-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] = 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8943279", "l": "GGT dimers hydrolyse GSH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32873", "l": "a carboxylate + glycerol + H(+) => a 2-acylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18171", "l": "glyoxylate + pyruvate => 4-hydroxy-2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114544", "l": "p115-RhoGEF activation of RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-996755", "l": "ZFPM proteins bind GATA proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47612", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.337", "l": "\"1,2-diacylglycerol 3-alpha-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24482", "l": "a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol => a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54716", "l": "N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102574", "l": "3-oxo-myristoyl-ACP hydrolase activity", "d": ["Catalysis of the reaction: H2O + a 3-oxo-myristoyl-[acp] = 3-oxo-myristate + H+ + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659989", "l": "Defective TALDO1 does not transform SH7P, GA3P to Fru(6)P, E4P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688456", "l": "MLKL binds FLOT1, FLOT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72739", "l": "chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out) = chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65935", "l": "3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine <=> 3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41460", "l": "1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1,2-diacylglycerol + a sphingomyelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37721", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44193", "l": "2-methylhexadecanoate + ATP + CoA => 2-methylhexadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74083", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + menadiol = diphosphate + menaquinol-4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61144", "l": "myricetin + UDP-beta-L-rhamnose = H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31448", "l": "6-amino-2-oxohexanoate + H2O2 => 5-aminopentanoate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66871", "l": "3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111915", "l": "CAMK4 autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70636", "l": "H2O + N(6)-octanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-octanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29148", "l": "2 H(+)(in) + nitrate + ubiquinol-8 => 2 H(+)(out) + H2O + nitrite + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45561", "l": "L-isoleucine => D-allo-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030196", "l": "cyanide hydratase activity", "d": ["Catalysis of the reaction: formamide = H2O + hydrogen cyanide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51392", "l": "(9Z)-octadecenoyl-CoA + serotonin = CoA + H(+) + N-(9Z-octadecenoyl)-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41864", "l": "(2E)-decenoyl-[ACP] + H(+) + NADPH = decanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62837", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28334", "l": "dATP + H2O = dAMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61903", "l": "AH2 + betaenone C <=> A + betaenone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71888", "l": "GTP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19798", "l": "1D-myo-inositol 1,4,5-trisphosphate + H2O => 1D-myo-inositol 1,4-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200396", "l": "Creatine transport across the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.20.98.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13527", "l": "(1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin] => (1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56727", "l": "AH2 + all-trans-beta-carotene + O2 <=> 4-hydroxy-all-trans-beta-carotene + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428625", "l": "Vesicular inhibitory amino acid transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65314", "l": "a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP] => an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10163", "l": "L-iditol + NAD(+) <=> H(+) + keto-L-sorbose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75163", "l": "NAD(+) + UTP = H(+) + NADP(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45917", "l": "12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28378", "l": "ATP + N(6)-(D-fructosyl)-L-lysine = ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine", "d": []}, {"i": "EC:2.7.1.218", "l": "\"fructoselysine 6-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55813", "l": "a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29583", "l": "guanosine(in) + H(+)(out) = guanosine(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65628", "l": "sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9646468", "l": "mTORC1 binds RHEB:GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29764", "l": "ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) => ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67804", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(20)-[histone H4] + O2 = CO2 + formaldehyde + L-lysyl(20)-[histone H4] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033895", "l": "ribonuclease [poly-(U)-specific] activity", "d": ["Catalysis of the endonucleolytic cleavage of poly(U) to fragments terminated by 3'-hydroxy and 5'-phosphate groups."]}, {"i": "EC:3.1.26.9", "l": "\"ribonuclease [poly-(U)-specific]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004638", "l": "phosphoribosylaminoimidazole carboxylase activity", "d": ["Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H+ = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44857", "l": "(9Z)-octadecenoyl-CoA + (R)-carnitine => CoA + O-(9Z)-octadecenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420243", "l": "GHRH receptor binds GHRH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20370", "l": "betaine aldehyde + H2O + O2 => glycine betaine + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416690", "l": "SEMA4A binds to PLXND1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693540", "l": "MRN activates ATM (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706364", "l": "Internalization of ubiquitinated FLT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64448", "l": "L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.370", "l": "\"[histone H3]-lysine(4) N-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20244", "l": "nicotinate + S-adenosyl-L-methionine <=> N-methylnicotinate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004398", "l": "histidine decarboxylase activity", "d": ["Catalysis of the reaction: L-histidine = histamine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601924", "l": "Primary piRNA transcript translocates from nucleoplasm to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41718", "l": "a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine => a 2-acyl-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400143", "l": "Fatty acid ligands activate PPARA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5631941", "l": "SESN1,2,3 bind AMPK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29367", "l": "CMP + H2O = cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20102", "l": "a long-chain fatty acid + ATP + L-cysteinyl-[protein] => AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62718", "l": "stemphyloxin II => stemphyloxin I", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904929", "l": "coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway", "d": ["Any coreceptor activity that is involved in Wnt signaling pathway, planar cell polarity pathway."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782434", "l": "THG1L transfers GMP to 5' end of tRNA(His) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11663", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O <=> acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.88", "l": "\"non-reducing end beta-L-arabinopyranosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.018172800177666", "identifiers": [{"i": "GO:0015377", "l": "chloride:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)."]}, {"i": "TCDB:2.A.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783880", "l": "PIPOX oxidises PPCA to P6C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53799", "l": "deoxycholoyl-CoA + ursodeoxycholate <=> deoxycholate + ursodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696997", "l": "USP24 deubiquitinates DDB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10630", "l": "a ribonucleoside 5'-diphosphate + tRNA(n) => phosphate + tRNA(n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73936", "l": "griseophenone B + H(+) + O2 + reduced [NADPH--hemoprotein reductase] => desmethyl-dehydrogriseofulvin + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28738", "l": "H(+)(in) + spermidine(out) <=> H(+)(out) + spermidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0003953", "l": "NAD+ nucleosidase activity", "d": ["Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322427", "l": "Beta-catenin recruits CBP/p300 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42792", "l": "cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68327", "l": "1D-myo-inositol 2,5-bisphosphate + H2O <=> 1D-myo-inositol 2-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432148", "l": "Fgr may phosphorylate p38 MAPK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102235", "l": "1-penten-3-one reductase activity", "d": ["Catalysis of the reaction: 1-penten-3-one + NADPH + H+ <=> 1-pentan-3-one + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15843", "l": "6-phospho-D-glucono-1,5-lactone + H(+) + NADPH => D-glucose 6-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45104", "l": "6-demethylmitomycin A + S-adenosyl-L-methionine = mitomycin A + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050393", "l": "vinylacetyl-CoA delta-isomerase activity", "d": ["Catalysis of the reaction: vinylacetyl-CoA = (2E)-butenoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636008", "l": "NEIL3 resolves abasic site-induced ICLs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54162", "l": "[ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20509", "l": "ATP + viomycin = ADP + H(+) + O-phosphoviomycin", "d": []}, {"i": "EC:2.7.1.103", "l": "\"viomycin kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102557", "l": "protopanaxadiol 6-hydroxylase activity", "d": ["Catalysis of the reaction: (20S)-protopanaxadiol + O2 + NADPH(4-) + H+ <=> protopanaxatriol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69753", "l": "(E)-cinnamoyl-CoA + CO2 + H2O2 => benzylmalonyl-CoA + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43516", "l": "2-carboxy-5-formylfuran + H2O = 2-carboxy-5-(dihydroxymethyl)furan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199404", "l": "CD40L binds CD40 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67309", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one => (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67630", "l": "(2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate => ATP + dGMP + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55036", "l": "an N,N-dimethylornithine lipid + S-adenosyl-L-methionine = an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12524", "l": "L-pipecolate + NADP(+) = Delta(1)-piperideine-2-carboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59423", "l": "H2O + methylamine + O2 <=> formaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665278", "l": "Resistant ERBB2 KD mutants do not bind AEE788 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111962", "l": "PDE4A,C,D hydrolyse cAMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22312", "l": "5-(methylsulfanyl)-D-ribose + ATP = ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}, {"i": "EC:2.7.1.100", "l": "\"S-methyl-5-thioribose kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36420", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17882", "l": "H2O + N-sulfo-D-glucosamine => D-glucosamine + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75617", "l": "ectocarpin B + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53760", "l": "allocholate + deoxycholoyl-CoA = allocholoyl-CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578965", "l": "TNRC6A binds AGO2:miRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35356", "l": "3-hydroxyisopentadecanoyl-CoA => (2E)-13-methyltetradecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34198", "l": "2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 <=> 2 aureusidin 6-O-beta-glucoside + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23152", "l": "a ubiquinone + H(+) + NADH = a ubiquinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102536", "l": "sakuranetin 6-hydroxylase activity", "d": ["Catalysis of the reaction: sakuranetin + O2 + NADPH + H+ <=> carthamidin-7-methyl ether + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617179", "l": "PRKACA phosphorylates TNNI3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389862", "l": "Conversion of glyoxylate to oxalate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71438", "l": "an aromatic L-alpha-amino acid(in) + L-thyroxine(out) <=> an aromatic L-alpha-amino acid(out) + L-thyroxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43886", "l": "3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH => 3-oxochol-4-en-22-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.181", "l": "\"13-deoxydaunorubicin hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58743", "l": "H2O + psi-UTP <=> diphosphate + H(+) + psi-UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420274", "l": "GIP receptor binds gastric inhibitory peptide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33840", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) => 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592316", "l": "Initial activation of proMMP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21053", "l": "(S)-2-hydroxypropyl-coenzyme M + NAD(+) => 2-oxopropyl-coenzyme M + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034828", "l": "4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H2O = 2-hydroxydec-2,4-diene-1,10-dioate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53740", "l": "[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O = [Rab1 protein]-L-tyrosine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001609", "l": "G protein-coupled adenosine receptor activity", "d": ["Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16865", "l": "choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050634", "l": "phloroisovalerophenone synthase activity", "d": ["Catalysis of the reaction: isovaleryl-CoA + 3 malonyl-CoA = 4 CoASH + 3 CO2 + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49244", "l": "NAD(+) + resolvin E1 = 18-oxo-resolvin E1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0005549", "l": "odorant binding", "d": ["Binding to an odorant, any substance capable of stimulating the sense of smell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61191", "l": "quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose <=> H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380311", "l": "Recruitment of Plk1 to centrosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71783", "l": "MDH2 reduces OA to MAL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0019862", "l": "IgA binding", "d": ["Binding to an immunoglobulin of an IgA isotype."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.344352379398387", "identifiers": [{"i": "GO:0016867", "l": "intramolecular transferase activity, transferring acyl groups", "d": ["Catalysis of the transfer of an acyl group from one position to another within a single molecule."]}, {"i": "EC:5.4.1.-", "l": "\"Transferring acyl groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70573", "l": "argininosuccinate <=> fumarate + arginine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43425", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870469", "l": "RGGT geranylgeranylates RAB proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110360", "l": "Recruitment of POLB to the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47172", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) = 5alpha-cholest-8-en-3-one + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29526", "l": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50420", "l": "L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] = H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32483", "l": "H(+) + H2O + pheophorbide a = CO2 + methanol + pyropheophorbide a", "d": []}, {"i": "EC:3.1.1.82", "l": "\"pheophorbidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634850", "l": "NPAS4 binds ARNT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65765", "l": "a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + H2O => (2E,4S)-4,5-dihydroxypent-2-enal + a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5681980", "l": "ATG12 binds ATG7 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31059", "l": "H2O + imidazole-4-acetaldehyde + NAD(+) = 2 H(+) + imidazole-4-acetate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690196", "l": "USP8 deubiquitinates RNF128 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13516", "l": "(S)-dihydroorotate + NAD(+) <=> H(+) + NADH + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73675", "l": "ADP(out) + dAMP(in) + H(+)(out) = ADP(in) + dAMP(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44531", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.75", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11511", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 <=> 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70915", "l": "guanosine(in) + H(+)(in) = guanosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54852", "l": "H(+) + heptan-4-one + NADPH + O2 = H2O + NADP(+) + propyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167484", "l": "Fall Back to Closed Pre-initiation Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38946", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11429", "l": "beta-D-glucose + O2 => D-glucono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65820", "l": "decanoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = dec-9-enoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44383", "l": "a 3-demethylubiquinol + S-adenosyl-L-methionine <=> a ubiquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804596", "l": "APAF1:CYCS binds APIP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047553", "l": "2-oxoglutarate synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21732", "l": "chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate", "d": []}, {"i": "EC:4.1.3.27", "l": "\"anthranilate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67741", "l": "N-acetyl-beta-neuraminate => aceneuramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42200", "l": "corticosterone + NADP(+) = 11-dehydrocorticosterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917730", "l": "Cargo Recognition And Sorting (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047920", "l": "geissoschizine dehydrogenase activity", "d": ["Catalysis of the reaction: geissoschizine + NADP+ = 4,21-dehydrogeissoschizine + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68908", "l": "ATP + H(+) + NADPH + picolinate = AMP + diphosphate + NADP(+) + picolinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25548", "l": "(+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate", "d": []}, {"i": "EC:4.2.3.32", "l": "\"levopimaradiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32234", "l": "(6S)-NADPHX + ATP <=> ADP + H(+) + NADPH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034022", "l": "3-(hydroxyamino)phenol mutase activity", "d": ["Catalysis of the reaction: 3-hydroxyaminophenol = aminohydroquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112395", "l": "Abortive termination of elongation after arrest (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0050220", "l": "prostaglandin-E synthase activity", "d": ["Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23646", "l": "H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase] => lithocholate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177922", "l": "EGFR dimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50956", "l": "cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39989", "l": "all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40075", "l": "6-amino-6-deoxyfutalosine + H(+) + H2O = futalosine + NH4(+)", "d": []}, {"i": "EC:3.5.4.40", "l": "\"aminodeoxyfutalosine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031624", "l": "ubiquitin conjugating enzyme binding", "d": ["Binding to a ubiquitin conjugating enzyme, any of the E2 proteins."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106158", "l": "glycero-3-phosphocholine acyltransferase activity", "d": ["Catalysis of the reaction:acyl-CoA + glycerophosphocholine = CoA + 1-acyl-sn-glycero-3-phosphocholine."]}, {"i": "RHEA:58476", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine = a 1-acyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36147", "l": "acetyl-CoA + benzyl alcohol = benzyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73909", "l": "ADP + aeruginascin + H(+) => 4-hydroxy-N,N,N-trimethyltryptamine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798372", "l": "ATM phosphorylates DYRK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445079", "l": "Phosphorylation of L1 by ERK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980122", "l": "DTX binds NOTCH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028583", "l": "Phosphorylation of YAP by LATS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-982810", "l": "JAK2 phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28034", "l": "[thioredoxin]-disulfide + dADP + H2O = [thioredoxin]-dithiol + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61249", "l": "H2O + L-tyrosine + O2 => 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806408", "l": "TP53 binds the PMS2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866941", "l": "MID1IP1 binds THRSP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74740", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine => 7,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66279", "l": "tigogenin + UDP-alpha-D-glucose <=> H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37990", "l": "delta-tocopherol <=> 2-methyl-6-phytyl-1,4-benzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0016163", "l": "nitrogenase activity", "d": ["Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14716", "l": "A + keto-L-sorbose <=> 5-dehydro-D-fructose + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64503", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine <=> 3-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2586553", "l": "JAK2 Phosphorylates LEPR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72741", "l": "chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in) => chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65699", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine <=> a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24212", "l": "5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.50", "l": "\"hydroxyethylthiazole kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16116", "l": "2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) <=> 2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28272", "l": "CoA + H(+) + N(8)-acetylspermidine => acetyl-CoA + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41022", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol <=> 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43828", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30074", "l": "acetyl-CoA + butanoate <=> acetate + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710263", "l": "GZMB cleaves GSDME (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23013", "l": "a fatty acid + S-adenosyl-L-methionine => a fatty acid methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68576", "l": "ATP + H2O + xanthine(out) = ADP + H(+) + phosphate + xanthine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61127", "l": "kaempferol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45979", "l": "3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48391", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.19", "l": "\"[protein ADP-ribosylarginine] hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73639", "l": "CTP(out) + ITP(in) = CTP(in) + ITP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951644", "l": "Release of mature NEDD8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32809", "l": "thiosulfate(out) => thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055104", "l": "ligase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a ligase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687097", "l": "p-S857 NCOA3 binds ETV4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11753", "l": "acetylsalicylate + H2O => acetate + H(+) + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71030", "l": "L-glutamine(in) + L-phenylalanine(out) <=> L-glutamine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16113", "l": "2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) = 2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH", "d": []}, {"i": "EC:1.16.1.6", "l": "\"cyanocobalamin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27415", "l": "CO2 + formaldehyde + morphine + succinate => 2-oxoglutarate + codeine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190256", "l": "FGFR1c binds to FGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2995330", "l": "COX10 transforms heme to heme O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72233", "l": "chloride(in) + N-methyl-L-proline(in) + 2 Na(+)(in) => chloride(out) + N-methyl-L-proline(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57423", "l": "NADH + 2 oxidized [cytochrome P450] <=> H(+) + NAD(+) + 2 reduced [cytochrome P450]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20360", "l": "3-phenylpropanoate + H(+) + NADH + O2 <=> 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672980", "l": "Dissociation of RAS:RAF complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20598", "l": "2 L-cysteine + NAD(+) => H(+) + L-cystine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050565", "l": "aerobactin synthase activity", "d": ["Catalysis of the reaction: ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine = aerobactin + AMP + diphosphate + H+."]}, {"i": "RHEA:32167", "l": "ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine = aerobactin + AMP + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.2.39", "l": "\"aerobactin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59264", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0043893", "l": "acetate:monoatomic cation symporter activity", "d": ["Enables the transfer of acetate from one side of a membrane to the other according to the reaction: acetate(out) + cation(out) = acetate(in) + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000103", "l": "CUBN:AMN binds CBLIF:RCbl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71651", "l": "a thymidine in DNA + NAD(+) = an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005046", "l": "KDEL sequence binding", "d": ["Binding to a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676133", "l": "CD74 binds MIF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985591", "l": "SLIT2-bound ROBO1 binds MYO9B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193774", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66330", "l": "taurine(in) => taurine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17467", "l": "L-rhamnopyranose + quercetin => H2O + quercitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21025", "l": "CoA + glyoxylate + NADP(+) => H(+) + NADPH + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.85", "l": "\"7-deoxyloganate 7-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:1902271", "l": "D3 vitamins binding", "d": ["Binding to D3 vitamins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72631", "l": "Formation of the cap-binding eIF4F complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390112", "l": "Phosphorylated HPO dimer phosphorylates WTS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15205", "l": "a dolichyl diphosphooligosaccharide + H2O = a dolichyl phosphate + an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + 2 H(+)", "d": []}, {"i": "EC:3.6.1.44", "l": "\"oligosaccharide-diphosphodolichol diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0071936", "l": "coreceptor activity involved in Wnt signaling pathway", "d": ["In cooperation with a primary Wnt receptor, initiating a change in cell activity through the Wnt signaling pathway."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30603", "l": "15-cis-phytoene + A = AH2 + all-trans-phytofluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48285", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose => globoside NOR1 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54235", "l": "1,2-dioctanoyl-sn-glycerol + CDP-choline <=> 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60757", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone => cinerin I + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000433", "l": "SUMOylation of PML with SUMO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213241", "l": "Formation of nonameric complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72928", "l": "O2 + proatranorin I + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin IV", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68053", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O => a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63518", "l": "biphenyl-2,2',3,3'-tetraol + H2O + NAD(+) => biphenyl-2,2',3-triol + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17023", "l": "L-alanine + phosphonoacetaldehyde => (2-aminoethyl)phosphonate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203700", "l": "eNOS translocation from Golgi to Caveolae (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868134", "l": "CAST binds Ca2+ bound calpain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46752", "l": "7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483186", "l": "PC is converted to PS by PTDSS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12131", "l": "2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41879", "l": "(3R)-hydroxydodecanoyl-[ACP] <=> (2E)-dodecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70891", "l": "L-asparagine(out) + L-glutamine(in) + Na(+)(out) = L-asparagine(in) + L-glutamine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51583", "l": "a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) <=> a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9010872", "l": "SLIT2 binds Dystroglycan (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33862", "l": "(2S-3S)-versiconal hemiacetal <=> H2O + versicolorin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27916", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate => 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51406", "l": "5-guanidino-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-arginine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.98.-.-", "l": "\"ATP-independent chelatases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20333", "l": "ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase]", "d": []}, {"i": "EC:2.7.11.27", "l": "\"[acetyl-CoA carboxylase] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762333", "l": "ANGPTL4 binds to CDH11v (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53611", "l": "4-hydroxyestrone + O2 <=> (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59809", "l": "L-tyrosine => D-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019166", "l": "trans-2-enoyl-CoA reductase (NADPH) activity", "d": ["Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33871", "l": "(S)-2-ureidoglycine + H2O = glyoxylate + NH4(+) + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64245", "l": "a fatty acyl-CoA + glycine => an N-(fatty acyl)-glycine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983147", "l": "Release of E3 from polyubiquitinated substrate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203774", "l": "Interaction of Csk with PAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005095", "l": "GTPase inhibitor activity", "d": ["Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58326", "l": "cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine => beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67165", "l": "bromide + FADH2 + melleolide F + O2 => 6'-bromomelleolide F + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24491", "l": "H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210290", "l": "Interaction of PECAM-1 and SHIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66663", "l": "ATP + beta-D-glucosylceramide(in) + H2O <=> ADP + beta-D-glucosylceramide(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16334", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] => diphosphate + holo-[citrate lyase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8979071", "l": "KDM6B binds iron (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14198", "l": "ATP + L-aspartate + NH4(+) => ADP + H(+) + L-asparagine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9650165", "l": "ASIC trimers bind H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247569", "l": "PADI4 deiminates Histones (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606273", "l": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51535", "l": "H(+) + NADPH + O2 + urate <=> 5-hydroxyisourate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50738", "l": "a quinol + thiosulfate => a quinone + 2 H(+) + hydrogen sulfide + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070123", "l": "transforming growth factor beta receptor activity, type III", "d": ["Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76064", "l": "3'-phosphoadenylyl sulfate(in) + adenosine 3',5'-bisphosphate(out) => 3'-phosphoadenylyl sulfate(out) + adenosine 3',5'-bisphosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052899", "l": "N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity", "d": ["Catalysis of the reaction: H2O + N(1),N(12)-diacetylspermine + O2 = 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40669", "l": "2-iminopropanoate => 2-aminoprop-2-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11545", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine => H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71360", "l": "17beta-estradiol 17-sulfate(out) + 2 Na(+)(out) => 17beta-estradiol 17-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39782", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5679239", "l": "ULK complex translocates to the ER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9794444", "l": "ALB binds Cipro (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102295", "l": "4-methylumbelliferyl glucoside 6'-O-malonyltransferase activity", "d": ["Catalysis of the reaction: 4-methylumbelliferyl glucoside + malonyl-CoA <=> 4-methylumbelliferone 6'-O-malonylglucoside + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55177", "l": "2-oxoglutarate + butanoyl-CoA + O2 => 2-hydroxybutanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177479", "l": "Axonal transport of NGF:Trk complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56415", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26020", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O => beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66566", "l": "5-histaminyl-L-glutamyl-[protein] + NH4(+) => histamine + L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16486", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate => 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54059", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (2E,6E)-hedycaryol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1369028", "l": "ABCAs mediate lipid efflux (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.481603666032214", "identifiers": [{"i": "GO:0005402", "l": "carbohydrate:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18552", "l": "[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71409", "l": "2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7beta-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57099", "l": "AH2 + S-methyl-1-thio-D-xylulose 5-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + A + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452097", "l": "Recruited STAT5 is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41654", "l": "2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+) => aclacinomycin S + dTDP-2-deoxy-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015492", "l": "phenylalanine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenylalanine(out) + H+(out) = phenylalanine(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390044", "l": "YKI is phosphorylated by and then dissociates from phosphorylated WTS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65610", "l": "CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + docosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36063", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + kunzeaol", "d": []}, {"i": "EC:4.2.3.143", "l": "\"kunzeaol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32037", "l": "(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+) => (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008684", "l": "TBK1 phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37778", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA <=> 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.9.-", "l": "\"Phosphotransferases with paired acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16231", "l": "a CDP-1,2-diacyl-sn-glycerol + diphosphate => a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21422", "l": "15-dehydro-prostaglandin I2 + H(+) + NADPH => NADP(+) + prostaglandin I2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73463", "l": "carcinine + H2O = beta-alanine + histamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42507", "l": "2-oxoglutarate + N(6)-acetyl-L-lysine <=> 6-acetamido-2-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200646", "l": "Cytosolic folate export across the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5490269", "l": "AFXBO-C, AFNBO-C translocate from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64250", "l": "CoA + H(+) + N-decanoylglycine => decanoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74315", "l": "O-isobutanoyl-(R)-carnitine(in) = O-isobutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0051033", "l": "RNA transmembrane transporter activity", "d": ["Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-203906", "l": "Exportin complex translocates pre-miRNA to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218847", "l": "PAK2 binds NCK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65353", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37183", "l": "(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951951", "l": "RUNX3 binds EP300 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167429", "l": "The receptor:G-protein complex  binds GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981832", "l": "NMUR2 binds neuromedin-S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60242", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13214", "l": "H2O + NADP(+) + succinate semialdehyde => 2 H(+) + NADPH + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17152", "l": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] <=> an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52073", "l": "12-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37842", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31068", "l": "6-amino-2-oxohexanoate => Delta(1)-piperideine-2-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24455", "l": "L-glutamyl-[protein] + S-adenosyl-L-methionine <=> [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26392", "l": "all-trans-beta-carotene + O2 <=> all-trans-10'-apo-beta-carotenal + beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13714", "l": "a ubiquinone + succinate => a ubiquinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10048", "l": "methanethiol + O-acetyl-L-homoserine = acetate + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034548", "l": "N-cyclopropylammeline deaminase activity", "d": ["Catalysis of the reaction: N-cyclopropylammeline + H2O = N-cyclopropylammelide + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419843", "l": "CALCA(83-119) binds CALCR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706308", "l": "Active FLT3 binds to GRB10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40180", "l": "decanoyl-CoA + O2 => (2E)-decenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050032", "l": "L-rhamnonate dehydratase activity", "d": ["Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183055", "l": "Binding of CBL to EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17111", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+) => FMNH2 + N-methylnicotinate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16054", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine => H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928614", "l": "EFNB:GRB4 binds GIT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2214351", "l": "PLK1 phosphorylates GORASP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428273", "l": "SPHK1 phosphorylates SPG to S1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20930", "l": "[DsbA protein]-disulfide + a quinol => [DsbA protein]-dithiol + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67039", "l": "(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + 2-oxoglutarate + O2 <=> (3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358519", "l": "MSH2:MSH3 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202500", "l": "Activation of IKK complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73758", "l": "2 H(+)(out) + histamine(in) <=> 2 H(+)(in) + histamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66307", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102834", "l": "1-18:1-2-16:0-monogalactosyldiacylglycerol acyl-lipid omega-6 desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63238", "l": "6-O-adenylylstreptomycin + diphosphate => ATP + streptomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0046920", "l": "alpha-(1->3)-fucosyltransferase activity", "d": ["Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11722", "l": "ADP + 2 H(+) + N-carbamoylsarcosine + phosphate => ATP + 2 H2O + N-methylhydantoin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008810", "l": "cellulase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109702", "l": "PDPK1 phosphorylates AKT2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70165", "l": "H(+)(out) + methotrexate(out) => H(+)(in) + methotrexate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848414", "l": "Activated PTK6 binds CDKN1B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202466", "l": "Interaction of Bcl10 to CARMA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051730", "l": "GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005111", "l": "type 2 fibroblast growth factor receptor binding", "d": ["Binding to a type 2 fibroblast growth factor receptor (FGFR2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15959", "l": "2-dehydro-3-deoxy-D-gluconate + H2O => D-altronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68373", "l": "L-asparagine + pyruvate => 2-oxosuccinamate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0031893", "l": "vasopressin receptor binding", "d": ["Binding to a vasopressin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202714", "l": "CD58 binds CD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357483", "l": "RAC1 binds PAK1-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170964", "l": "FRS2 binds to active TrkA receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69068", "l": "RFC dissociates after sliding clamp formation (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39341", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+) => (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66838", "l": "asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase] => 4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41101", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27631", "l": "ethylene glycol + NAD(+) => glycolaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53047", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052667", "l": "phosphomethylethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.296", "l": "\"omega-hydroxyceramide transacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0038102", "l": "activin receptor antagonist activity", "d": ["Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61765", "l": "stevioside + UDP-alpha-D-glucose => H(+) + rebaudioside E + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190519", "l": "Internalization of gap junction plaques (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40599", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50811", "l": "glutathione + prostaglandin J2 <=> prostaglandin J2-S-(S)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73827", "l": "an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061761", "l": "alpha-latrotoxin receptor binding", "d": ["Binding to an alpha-latrotoxin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753634", "l": "GGT dimers hydrolyse APAP-SG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67505", "l": "1-nonadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607058", "l": "Activated protein C:PROCR binds F2R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981353", "l": "RASA1 stimulates RAS GTPase activity (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75572", "l": "acetyl-CoA + cyathin A3 => 11-O-acetylcyathin A3 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5099899", "l": "WNT5A binds FZD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48608", "l": "A + a 2,3-saturated acyl-CoA = a 2,3-dehydroacyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65302", "l": "CO2 + H2O + succinate + verruculide A => 2-oxoglutarate + chrodrimanin C + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40863", "l": "FAD + H(+) + heptadecanoyl-CoA = FADH2 + trans-2-heptadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788623", "l": "p-Y-STATs translocate to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004876", "l": "complement component C3a receptor activity", "d": ["Combining with the C3a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448632", "l": "IL34 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25776", "l": "scyllo-inosose = scyllo-inosine", "d": []}, {"i": "EC:5.3.99.11", "l": "\"2-keto-myo-inositol isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44549", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61744", "l": "steviolbioside + UDP-alpha-D-glucose = stevioside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68931", "l": "ATP + H(+) + heptanoate + NADPH <=> AMP + diphosphate + heptanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791112", "l": "Expression of HDGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675431", "l": "PP2A dephosphorylates RAF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110035", "l": "rDNA spacer replication fork barrier binding, bending", "d": ["The activity of binding selectively, and in a sequence-specific manner, a replication fork barrier found in rDNA spacers, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69149", "l": "H2O + O2 + spermine => H2O2 + NH4(+) + spermine monoaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32246", "l": "alpha-D-ribose 1,5-bisphosphate <=> D-ribulose 1,5-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730886", "l": "Phosphorylation of SHC by SYK kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114254", "l": "CYCS binds to APAF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28452", "l": "N(6)-(D-psicosyl)-L-lysine(out) => N(6)-(D-psicosyl)-L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73848", "l": "17alpha-hydroxywithaferin A + UDP-alpha-D-glucose => 17alpha-sitoindoside IX + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0140064", "l": "peptide crotonyltransferase activity", "d": ["Catalysis of the reaction: crotonyl-CoA + lysine in peptide = CoA + N-crotonyl-lysine-peptide."]}, {"i": "RHEA:53908", "l": "(2E)-butenoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60232", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72265", "l": "chloride(in) + oxalate(out) => chloride(out) + oxalate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28677", "l": "beta-D-galactose => alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20099", "l": "2-dehydro-3-deoxy-D-gluconate + H2O => D-mannonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977301", "l": "Histidine is decarboxylated to histamine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40587", "l": "H2O + octanedioyl-CoA = CoA + H(+) + octanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67813", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine => a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34839", "l": "4 H(+) + 5 malonyl-CoA = 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O", "d": []}, {"i": "EC:2.3.1.216", "l": "\"5,7-dihydroxy-2-methylchromone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.72", "l": "\"IgA-specific serine endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-179417", "l": "Multiubiquitination of Nek2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18183", "l": "(S)-malate + CoA + H(+) => acetyl-CoA + glyoxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22489", "l": "S-(hydroxymethyl)glutathione => formaldehyde + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36137", "l": "(E)-hexadec-2-enoate + 2 H(+) + NADH => (2E)-hexadecenal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465924", "l": "OPN1LW binds 11cRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139909", "l": "Translocation of BMF to mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60463", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034853", "l": "2,4,4-trimethyl-3-oxopentanoate decarboxylase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoate + H+ = 2,2-dimethyl-3-pentanone + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69244", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate = 5-methylsulfinylpentyl nitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44855", "l": "(5Z)-tetradecenoyl-CoA + (R)-carnitine <=> CoA + O-(5Z)-tetradecenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23835", "l": "an N-acyl-D-mannosamine + ATP <=> ADP + an N-acyl-D-mannosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62279", "l": "3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine <=> 6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29458", "l": "D-serine(in) <=> D-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850945", "l": "Casein kinase II phosphorylates PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64674", "l": "butyl 2-(methylsulfanyl)acetate + CoA => 2-(methylsulfanyl)acetyl-CoA + butan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0019975", "l": "interleukin-17 binding", "d": ["Binding to a member of the interleukin-17 family of cytokines."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61722", "l": "a 3-dehydro-D-guloside + H(+) + NADH => a D-guloside + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018485", "l": "salicylaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: salicylaldehyde + NAD+ + H2O = salicylate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67161", "l": "chloride + FADH2 + melleolide F + O2 => 6'-chloromelleolide F + FAD + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23814", "l": "(1R,4S)-menthone + H(+) + NADPH => (+)-neomenthol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016966", "l": "nitric oxide reductase activity", "d": ["Catalysis of the reaction: H2O + 2 ferricytochrome c + nitrous oxide = 2 H+ + 2 ferrocytochrome c + 2 nitric oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69521", "l": "H2O + N-acetyl-D-galactosamino-1,5-lactone => H(+) + N-acetyl-D-galactosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22734", "l": "4-methylphenol + CO2 => 4-hydroxyphenylacetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675947", "l": "TNFSF18 binds TNFRSF18 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26448", "l": "H(+) + malonyl-CoA + NADPH => 3-oxopropanoate + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31939", "l": "2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] = DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.110", "l": "\"2-hydroxy-1,4-benzoxazin-3-one monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28813", "l": "2,3-dioxo-L-gulonate(out) + Na(+)(out) => 2,3-dioxo-L-gulonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102433", "l": "phenylalanine 4-hydroxylase (N10-formyl-tetrahydrofolate dependent) activity", "d": ["Catalysis of the reaction: L-phenylalanine + O2 + an N10-formyl-tetrahydrofolate <=> L-tyrosine + a 10-formyltetrahydrofolate-4a-carbinolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42594", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140836", "l": "RNA polymerase II CTD heptapeptide repeat S5 kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 5)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39234", "l": "3-oxo-triacontanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxytriacontanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26431", "l": "(+)-copalyl diphosphate + H2O => diphosphate + phyllocladan-16alpha-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102481", "l": "3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase activity", "d": ["Catalysis of the reaction: 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O <=> 5-deoxy-D-glucuronate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53449", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31117", "l": "biotinyl-5'-AMP + diphosphate => ATP + biotin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44588", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734572", "l": "Expression of MEF2C in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004438", "l": "phosphatidylinositol-3-phosphate phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389463", "l": "Proteinase-activated receptors can bind thrombin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627078", "l": "XIAP binds CASP9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203977", "l": "SAR1 Activation And Membrane Binding (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5226999", "l": "ADD1:ADD3 binds DMTN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853792", "l": "RET tyrosine phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11340", "l": "5-guanidino-2-oxopentanoate + H(+) = 4-guanidinobutanal + CO2", "d": []}, {"i": "EC:4.1.1.75", "l": "\"5-guanidino-2-oxopentanoate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9761344", "l": "USP18 binds IKBKG within IKK complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65478", "l": "CoA + propyl butanoate => 1-propanol + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23349", "l": "(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) => (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686930", "l": "RIPK3 is cleaved by CASP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191784", "l": "snRNA Cap hypermethylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2691226", "l": "NOTCH1 HD domain mutants bind JAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45354", "l": "9,10-dihydroxyoctadecanoate => 9,10-epoxyoctadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693608", "l": "Initial resection of double-strand break ends (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54494", "l": "1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36743", "l": "heptadecasphing-4-enine + tetracosenoyl-CoA = CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34522", "l": "N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine <=> [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42188", "l": "3beta-hydroxy-5alpha-androstan-17-one + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6795473", "l": "PDPK1 phosphorylates SGK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12047", "l": "a triacylglycerol + H2O <=> a diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564184", "l": "Collagen type IX degradation by MMP3,13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5444516", "l": "Formation of MSH2:MSH6 Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60385", "l": "enterobactin + H2O => N-(2,3-dihydroxybenzoyl)-L-serine trimer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47421", "l": "A + glutaryl-CoA => (2E)-glutaconyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42183", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693478", "l": "HTR1A binds HTR1A agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047380", "l": "ADP-dependent medium-chain-acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. Requires ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662613", "l": "MT3 exchanges zinc for copper (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17618", "l": "leukotriene C4 => glutathione + leukotriene A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377640", "l": "Autophosphorylation of SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58116", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.376", "l": "\"EGF-domain serine glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14354", "l": "3-dehydro-L-gulonate 6-phosphate + H(+) => CO2 + L-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209944", "l": "25(OH)D binds GC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176175", "l": "Stalling of DNA replication fork and RPA binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47285", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40485", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15292", "l": "[(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose <=> [(1->4)-beta-D-xylan](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615801", "l": "MECP2 binds IRAK1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018766", "l": "RHOU binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41074", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61452", "l": "H(+) + NADPH + O2 + oxytetracycline = 11a-hydroxy-oxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68185", "l": "a medium-chain fatty acyl-CoA + H2O => a medium chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61395", "l": "ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670189", "l": "F8 variant does not bind the cell membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61759", "l": "stevioside + UDP-alpha-D-glucose <=> H(+) + rebaudioside A + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16576", "l": "2-oxoglutarate + 4-(phosphooxy)-L-threonine <=> (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633314", "l": "TP53 stimulates NDRG1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22391", "l": "acetyl-CoA + N(6)-hydroxy-L-lysine <=> CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24368", "l": "L-ornithine = L-proline + NH4(+)", "d": []}, {"i": "EC:4.3.1.12", "l": "\"ornithine cyclodeaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36087", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23132", "l": "3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite", "d": []}, {"i": "EC:1.8.7.1", "l": "\"assimilatory sulfite reductase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72082", "l": "3 Na(+)(out) + selenate(out) <=> 3 Na(+)(in) + selenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68608", "l": "H(+) + isatin + NADPH = 3-hydroxyindolin-2-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759158", "l": "SQSTM1 oligomerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102219", "l": "phosphogluco-amylopectin water dikinase activity", "d": ["Catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-amylopectin = n AMP + n hydrogenphosphate + a 6-phosphogluco-3-phosphogluco-amylopectin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12712", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54351", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56938", "l": "testosterone => 17beta-hydroxy-androst-5-en-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21490", "l": "beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+) => dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62701", "l": "H2O + naphtopyrone YWA1 => acetoacetate + H(+) + naphthalene-1,3,6,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15245", "l": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61813", "l": "3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose => dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162657", "l": "Inactivation of Myt1 kinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700181", "l": "Autophosphorylation of ALK fusions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20269", "l": "4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate", "d": []}, {"i": "EC:4.2.2.6", "l": "\"oligogalacturonide lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24802", "l": "2-oxoglutarate + L-isoleucine => (S)-3-methyl-2-oxopentanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47351", "l": "a butanoate ester + H2O <=> an aliphatic alcohol + butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73082", "l": "S-adenosyl-L-methionine + scutellarein <=> S-adenosyl-L-homocysteine + scutellarein 7-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043955", "l": "3-hydroxypropionyl-CoA synthetase activity", "d": ["Catalysis of the reaction: 3-hydroxypropionate + ATP + CoA = 3-hydroxypropionyl-CoA + AMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32062", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O <=> (R)-glycerate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449872", "l": "acetaldehyde [cytosolic] => acetaldehyde [mitochondrial] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66409", "l": "ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O => ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30267", "l": "2 monodehydro-L-ascorbate radical = L-ascorbate + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40718", "l": "dihydroxyacetone phosphate + hexadecanoyl-CoA <=> 1-hexadecanoylglycerone 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064932", "l": "WWTR1 (TAZ) binds RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37799", "l": "2 H(+) + 2 NADH + O2 = 2 H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912372", "l": "Fringe-modified Pre-NOTCH is cleaved by FURIN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-396941", "l": "Thrombin-activated PARs binds G-protein G12/13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43383", "l": "H2O + N(omega)-phospho-L-arginyl-[protein] <=> L-arginyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336184", "l": "GPR37L binds prosaposin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18753", "l": "[protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102939", "l": "3-methoxy-5-hydroxytoluene O-methyltransferase activity", "d": ["Catalysis of the reaction: 3-methoxy-5-hydroxytoluene + S-adenosyl-L-methionine = H+ + 3,5-dimethoxytoluene + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40654", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805285", "l": "PLK3 phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209307", "l": "Phosphorylated STAT92E dimer activates transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29182", "l": "a menaquinol + 2 O2 <=> a menaquinone + 2 H(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46262", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610732", "l": "GSK3 phosphorylates p-GLI3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33720", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42761", "l": "D-glyceraldehyde 3-phosphate + H2O + NAD(+) => (2R)-3-phosphoglycerate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18750", "l": "[protein]-dithiol + NAD(+) => [protein]-disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68673", "l": "16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 16alpha,17beta-estriol 16-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16100", "l": "acetylpyruvate + H2O <=> acetate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60199", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444661", "l": "HCAR2 binds HCAR2 ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51624", "l": "formate + GTP + H(+) = CO2 + dGTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669240", "l": "FLNA binds PAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047799", "l": "cyclopentanone monooxygenase activity", "d": ["Catalysis of the reaction: cyclopentanone + H+ + NADPH + O2 = 5-valerolactone + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197588", "l": "NICD2 binds RBPJ and MAML in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61528", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base = a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203979", "l": "Coat Assembly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102076", "l": "beta,beta-carotene-9',10'-cleaving oxygenase activity", "d": ["Catalysis of the reaction: beta-carotene + O2 <=> 10'-apo-beta-carotenal + beta-ionone."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047162", "l": "17-O-deacetylvindoline O-acetyltransferase activity", "d": ["Catalysis of the reaction: (1R,9R,10S,11R,12R,19R)-12-ethyl-10,11-dihydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + acetyl-CoA = (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18689", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}, {"i": "EC:3.1.1.32", "l": "\"phospholipase A1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29455", "l": "D-serine(in) = D-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2314686", "l": "ASA- acetylates PTGS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982810", "l": "JAK2 phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44775", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 <=> 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64347", "l": "4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2 <=> 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192123", "l": "CYP27A1 27-hydroxylates CHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729283", "l": "Nucleoprotein is methylated by PRMT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27934", "l": "(3S)-3-hydroxy-D-aspartate = glycine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73822", "l": "choline(in) + 2 H(+)(out) <=> choline(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73011", "l": "L-leucine(in) = L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57201", "l": "glyoxal + L-arginyl-[protein] => N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53317", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37608", "l": "(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5227009", "l": "ABCF1 binds EIF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11372", "l": "ATP + L-aspartate + NH4(+) = AMP + diphosphate + H(+) + L-asparagine", "d": []}, {"i": "EC:6.3.1.1", "l": "\"aspartate--ammonia ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52446", "l": "2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70504", "l": "H2O + isopentenyl diphosphate => H(+) + isopentenyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52606", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+) => 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27482", "l": "(S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase] => acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668605", "l": "RAC2:GTP binds NOX2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41909", "l": "(3R)-hydroxyhexadecanoyl-[ACP] => (2E)-hexadecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0098638", "l": "laminin binding involved in cell-matrix adhesion", "d": ["Any laminin protein binding that occurs as part of cell-matrix adhesion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937613", "l": "CRHBP binds CRH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57578", "l": "H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23270", "l": "glycine + urea => guanidinoacetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16192", "l": "3-(4-hydroxyphenyl)pyruvate + O2 <=> CO2 + homogentisate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849463", "l": "PTK6 phosphorylates SFPQ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102423", "l": "(+)-sesaminol 2-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: (+)-sesaminol + UDP-alpha-D-glucose <=> (+)-sesaminol 2-O-beta-D-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106327", "l": "acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66045", "l": "2-oxobutanoate + L-kynurenine => (2S)-2-aminobutanoate + H2O + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43205", "l": "cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013438", "l": "RHOD binds effectors at the endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38081", "l": "1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112437", "l": "Formation of NELF complex  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114264", "l": "Translocation of activated BAX to the mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16794", "l": "H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => (R)-4'-phosphopantetheine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43745", "l": "ATP + cytidine(34) in tRNA(Ile2) + L-lysine => AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41815", "l": "(2E)-butenoyl-[ACP] + H(+) + NADPH <=> butanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030627", "l": "pre-mRNA 5'-splice site binding", "d": ["Binding to a pre-mRNA 5' splice site sequence."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60077", "l": "4beta-hydroxymethyl-4alpha-methylzymosterol + H(+) + NADH + O2 => 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664285", "l": "IgG binds the surface of the amastigote form of Leishmania (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17027", "l": "H(+) + L-xylulose + NADPH => NADP(+) + xylitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43143", "l": "guanosine(26) in tRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75805", "l": "butanoate(in) + Na(+)(in) => butanoate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.9", "l": "\"microsomal epoxide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247849", "l": "WLS dissociates from retromer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194678", "l": "CYP51A1 demethylates LNSOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170846", "l": "TGFBR2 recruits TGFBR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17697", "l": "pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine", "d": []}, {"i": "EC:2.5.1.2", "l": "\"thiamine pyridinylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193665", "l": "MYD88 dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14774", "l": "2 NADPH + palmatine + S-adenosyl-L-methionine => corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61265", "l": "H2O + L-alanine + O2 => H2O2 + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.99.-", "l": "\"With H(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5658430", "l": "NF1 is degraded by the proteasome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46035", "l": "H2O2 + tetradecanoate <=> (2S)-hydroxytetradecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139842", "l": "Binding of Syk tyrosine kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68096", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end ribonucleotide-RNA + a 5'-end (5'-phospho)-ribonucleoside-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59270", "l": "AH2 + formaldehyde + L-lysyl-[protein] => A + H2O + N(6)-methyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9815510", "l": "MIB2 binds CYLD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75172", "l": "Formation of RAD50:MRE11 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928631", "l": "GIT1 binds bPIX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033953", "l": "alpha-agarase activity", "d": ["Catalysis of the endohydrolysis of 1,3-alpha-L-galactosidic linkages in agarose, yielding agarotetraose as the major product."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.12", "l": "\"ribonuclease E\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6791016", "l": "SFTPB binds itself (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59963", "l": "N(alpha)-acetyl-D-methionine <=> N(alpha)-acetyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23499", "l": "5-hydroxypentanoate + acetyl-CoA <=> 5-hydroxy-pentanoyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74707", "l": "Binding of IRS to insulin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693243", "l": "RHOD translocates to the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050539", "l": "maleimide hydrolase activity", "d": ["Catalysis of the reaction: H2O + maleimide = H+ + maleamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209903", "l": "Noradrenaline is converted to adrenaline (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44358", "l": "methyl nogalonate => nogalaviketone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44591", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392195", "l": "Gi activation by P2Y purinoceptor 12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50718", "l": "FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate => dimethyl sulfone + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691174", "l": "RAC1 binds effectors at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47678", "l": "ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate => ATP + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57492", "l": "H2O + oxaloacetate + propanoyl-CoA = 2-methylcitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75899", "l": "1,2-diacyl-sn-glycero-3-phospho-N-acyl-L-serine + H2O = 1-acyl-sn-glycero-3-phospho-N-acyl-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20769", "l": "3-phosphonopyruvate + H(+) => CO2 + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163625", "l": "Glucagon binds to Glucagon receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14317", "l": "morphine + NAD(+) = H(+) + morphinone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40915", "l": "1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.45", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.113", "l": "\"(4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29403", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 = 3-demethylubiquinol-8 + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682011", "l": "LC3 binds ATG7 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852552", "l": "MST1R autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18991", "l": "2-methylpropan-1-amine + CO2 => H(+) + L-valine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50656", "l": "3-(2-methylsulfanyl)ethylmalate = 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784204", "l": "JAKs bind OSMR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654409", "l": "Activated FGFR3 binds FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45631", "l": "holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein] <=> holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947499", "l": "Exchange of oxygen with sulfur in MoCo (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216043", "l": "Collagen type II binds integrin alpha10beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975134", "l": "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5617179", "l": "PRKACA phosphorylates TNNI3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390663", "l": "ADRA2A,B,C bind ADR,NAd (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69752", "l": "benzylmalonyl-CoA + H(+) + O2 => (E)-cinnamoyl-CoA + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14631", "l": "ADP + N-acetyl-L-glutamyl 5-phosphate => ATP + N-acetyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58552", "l": "15alpha-stemmadenine intermediate II + H2O = (16R)-deshydroxymethyl-stemmadenine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57379", "l": "(S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31968", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9733292", "l": "AMY1-3 bind pramlintide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0019905", "l": "syntaxin binding", "d": ["Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28330", "l": "H2O + ITP = H(+) + IDP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44865", "l": "a triacyl-sn-glycerol + H2O => a 1,2-diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070984", "l": "SET domain binding", "d": ["Binding to a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73443", "l": "2-oxoglutarate + gardenin B + O2 = CO2 + formaldehyde + H(+) + nevadensin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65094", "l": "aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase] => asperaculane G + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015538", "l": "sialic acid:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + H+(out) = sialate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64964", "l": "dUTP + 2 H2O = dUMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204873", "l": "Interaction of Tie2 and Shp2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69828", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R,23R)-22,23-dihydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10279", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) <=> 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55811", "l": "a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58529", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH => (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71528", "l": "thymine(out) => thymine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44420", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35081", "l": "doxorubicin(out) => doxorubicin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29351", "l": "Zn(2+)(in) = Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49989", "l": "acetone + H(+) + NADPH + O2 => H2O + methyl acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18210", "l": "(2E)-geranyl diphosphate => (2S,4R)-bornyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26450", "l": "CoA + NADP(+) + succinate semialdehyde = H(+) + NADPH + succinyl-CoA", "d": []}, {"i": "EC:1.2.1.76", "l": "\"succinate-semialdehyde dehydrogenase (acetylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201639", "l": "Caspase-mediated cleavage of GAS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34166", "l": "hydroquinone + O2 <=> (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15568", "l": "an N-acyl-L-amino acid + H2O <=> a carboxylate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52350", "l": "(24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72647", "l": "Cap-bound mRNA is activated by helicases  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0035591", "l": "signaling adaptor activity", "d": ["The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008316", "l": "structural constituent of vitelline membrane", "d": ["The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25985", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (5R)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.93", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0016933", "l": "extracellularly glycine-gated ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296127", "l": "Activation of voltage gated Potassium channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49163", "l": "1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40938", "l": "a 1-acylglycerone 3-phosphate + hexadecan-1-ol <=> 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848110", "l": "SOCS3 binds activated PTK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9724745", "l": "PLG(20-810) binds aprotinin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41035", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791163", "l": "Expression of HSP90B1 (Endoplasmin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63582", "l": "20-hydroxyecdysone + phosphate => 20-hydroxyecdysone 22-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70812", "l": "4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde 3-phosphate => D-xylulose 5-phosphate + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222093", "l": "BRD7 binds TP53 and EP300 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54462", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate => 1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69915", "l": "guanosine(out) + 2 Na(+)(out) = guanosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71275", "l": "2 Na(+)(out) + taurolithocholate 3-sulfate(out) = 2 Na(+)(in) + taurolithocholate 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869580", "l": "DEK binds TFAP2A homodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27497", "l": "3'-O-methyltricetin + S-adenosyl-L-methionine = 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54483", "l": "1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602473", "l": "Autocatalytic activation of MMP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788611", "l": "HYKK phosphorylates 5HLYS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354124", "l": "Phosphorylation of pPTK2 by SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21684", "l": "(R)-beta-alanopine + H2O + NAD(+) = beta-alanine + H(+) + NADH + pyruvate", "d": []}, {"i": "EC:1.5.1.26", "l": "\"beta-alanopine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56654", "l": "12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.125", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689317", "l": "Formation of the pre-incision complex in GG-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798020", "l": "TP53 binds the BTG2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75419", "l": "(R,S)-butane-2,3-diol + NAD(+) = (S)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655828", "l": "Expression of Lanosterol Synthase (LSS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696274", "l": "RND1 binds GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0005507", "l": "copper ion binding", "d": ["Binding to a copper (Cu) ion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1237119", "l": "Acireductone is oxidized to MOB (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41763", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E)) <=> CMP + ganglioside GD3 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73192", "l": "(2R,3S,11R)-aszonalenin + acetyl-CoA => (2R,3S,11R)-acetylaszonalenin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53360", "l": "5,6-dihydrouridine(47) in tRNA + NADP(+) = H(+) + NADPH + uridine(47) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44268", "l": "3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA = 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26531", "l": "4-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299338", "l": "Activation of TRESK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67803", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-lysyl(27)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55827", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide d <=> a bacteriochlorophyllide f + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358789", "l": "Self-ubiquitination of RNF41 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682712", "l": "nsp15 binds RB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0141053", "l": "histone H2A ubiquitin ligase activity", "d": ["Catalysis of the transfer of ubiquitin to a histone H2A substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22062", "l": "2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] => (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61561", "l": "gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67396", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + O2 + reduced [NADPH--hemoprotein reductase] = 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061661", "l": "FAT10 ligase activity", "d": ["Catalysis of the transfer of FAT10 to a substrate protein via the reaction X-FAT10 + S = X + S-FAT10, where X is either an E2 or E3 enzyme, the X-FAT10 linkage is a thioester bond, and the S-FAT10 linkage is an isopeptide bond between the C-terminal glycine of FAT10 and the epsilon-amino group of lysine residues in the substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35161", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol => (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44326", "l": "butanoate + glycerol + H(+) => 1-butyrylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51154", "l": "3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide => 2 a thiol + L-cysteinyl-[sulfatase] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786190", "l": "CMBL hydrolyses OM to OLMS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33118", "l": "malonate(in) <=> malonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047928", "l": "gibberellin beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + gibberellin = UDP + gibberellin 2-O-beta-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18967", "l": "H2O + uroporphyrinogen III => hydroxymethylbilane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38219", "l": "(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68168", "l": "N-(8'-oxogeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672980", "l": "Dissociation of RAS:RAF complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41999", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose <=> globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090488", "l": "polo box domain specific binding", "d": ["Binding to a polo box domain of a protein. The polo box domain is involved in binding substrates of polo kinases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013009", "l": "RHOA binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64607", "l": "L-seryl-[protein] + UTP <=> diphosphate + uridylyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51903", "l": "H2O + N(1)-acetylspermidine <=> acetate + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672948", "l": "MARK3 phosphorylates KSR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684836", "l": "CLEC1B dimer binds PDPN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59291", "l": "beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O <=> D-glucose + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31249", "l": "prop-2-yn-1-ol + pyrroloquinoline quinone => H(+) + prop-2-ynal + pyrroloquinoline quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.11", "l": "\"phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34822", "l": "dihydrocurcumin + NADP(+) <=> curcumin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66780", "l": "6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O = N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.863640214551324", "identifiers": [{"i": "GO:0004807", "l": "triose-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60915", "l": "cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine <=> H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868118", "l": "MAPK12 phosphorylates PTPN3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64763", "l": "H2O + S-ethyl-L-cysteine <=> ethanethiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1471322", "l": "Beta-defensins are secreted (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685838", "l": "CX3 complex binds D-loop structures (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32997", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198508", "l": "MDH1 oxidizes MAL to OA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58831", "l": "(9S,10R)-epoxy-octadecanoate + H2O <=> 9R,10R-dihydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15207", "l": "a dolichyl phosphate + an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + 2 H(+) => a dolichyl diphosphooligosaccharide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53827", "l": "NAD(+) + taurochenodeoxycholate <=> 7-oxotaurolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170810", "l": "nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73809", "l": "N(7)-methyl-GDP + S-adenosyl-L-homocysteine => GDP + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29330", "l": "(S)-malate(in) + succinate(out) <=> (S)-malate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69513", "l": "H2O + N-acetyl-D-galactosamine + O2 => H(+) + H2O2 + N-acetyl-D-galactosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46913", "l": "H2O + juvenile hormone III => H(+) + juvenile hormone III carboxylate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56205", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] => 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683593", "l": "ATG7:ATG3:LC3 dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848829", "l": "CBL autoubiquitinates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50572", "l": "acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614614", "l": "Cysteine is degraded to serine and H2S (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14854", "l": "4-chlorobenzoyl-CoA + H2O => 4-hydroxybenzoyl-CoA + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30719", "l": "acetyl-CoA + propanoyl-CoA = 2-methyl-3-oxobutanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35778", "l": "L-glutamine + UDP-3-oxo-alpha-D-glucose <=> 2-oxoglutaramate + UDP-alpha-D-kanosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17932", "l": "an N-acylsphing-4-enine + ATP <=> ADP + an N-acylsphing-4-enine 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68392", "l": "H2O + peracetic acid = acetate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70944", "l": "L-isoleucine(in) => L-isoleucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036373", "l": "L-fucose mutarotase activity", "d": ["Catalysis of the reaction: alpha-L-fucose = beta-L-fucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37412", "l": "aklavinone + NADP(+) => aklaviketone + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016443", "l": "bidentate ribonuclease III activity", "d": ["Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46931", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39785", "l": "(17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73219", "l": "L-xylopyranose(out) + 2 Na(+)(out) = L-xylopyranose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28367", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate => beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2203516", "l": "Alpha-1-Microglobulin is cleaved (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093327", "l": "EPHA binds TIAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52311", "l": "2-hydroxyglutarate + NADP(+) <=> 2-oxoglutarate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66623", "l": "5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> (25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49595", "l": "2-hydroxyisobutanoyl-CoA <=> (3S)-3-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10204", "l": "dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] = formaldehyde + methylamine + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.5.8.1", "l": "\"dimethylamine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811479", "l": "ING2 recruits EP300 to TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12769", "l": "A + D-gluconate = 2-dehydro-D-gluconate + AH2", "d": []}, {"i": "EC:1.1.99.3", "l": "\"gluconate 2-dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70998", "l": "L-cystine(out) + L-glutamate(in) <=> L-cystine(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72192", "l": "cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69941", "l": "6alpha-hydroxytyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxotyphasterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.42903515889401", "identifiers": [{"i": "GO:0042379", "l": "chemokine receptor binding", "d": ["Binding to a chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451311", "l": "Activation of Ca-permeable Kainate receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008748", "l": "N-ethylmaleimide reductase activity", "d": ["Catalysis of the reaction: N-ethylmaleimide + NADPH + 2 H+ = N-ethylsuccinimide + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71515", "l": "hypoxanthine(out) = hypoxanthine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54756", "l": "deamido-NAD(+) + hydrogencarbonate = AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide", "d": []}, {"i": "EC:2.5.1.143", "l": "\"pyridinium-3,5-biscarboxylic acid mononucleotide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43935", "l": "3beta-hydroxyandrost-5-en-17-one + NAD(+) <=> androst-5-ene-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31310", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66150", "l": "CoA + H(+) + N-(2-phenylethyl)acetamide => 2-phenylethylamine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67607", "l": "H2O + N(6)-methyl-dATP <=> diphosphate + H(+) + N(6)-methyl-dAMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2129362", "l": "Fibrillin microfibril assembly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.3", "l": "\"protein-synthesizing GTPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004720", "l": "protein-lysine 6-oxidase activity", "d": ["Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43698", "l": "diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24929", "l": "NH4(+) + pyruvate + S-sulfanyl-L-cysteine => H2O + L-cystine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090416", "l": "nicotinate transmembrane transporter activity", "d": ["Enables the transfer of nicotinate from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41566", "l": "aclacinomycin T + dTDP + 2 H(+) => aklavinone + dTDP-beta-L-rhodosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71187", "l": "3-hydroxy-L-kynurenine(out) + L-tryptophan(in) = 3-hydroxy-L-kynurenine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67463", "l": "(R)-malate + A <=> AH2 + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984671", "l": "Chromokinesins form dimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38145", "l": "CO2 + 2 H(+) + 2 hydrogen sulfide => carbon disulfide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76030", "l": "(S)-reticuline + 2-oxoglutarate + O2 <=> (S)-6-O-demethylreticuline + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-976801", "l": "Complement factor I complex formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73099", "l": "3'-dephospho-CoA(in) + AMP(out) = 3'-dephospho-CoA(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168886", "l": "Hemopexin binds Hemes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5658430", "l": "NF1 is degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53811", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977375", "l": "CR1 binds C3bBb/C4bC2a (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944078", "l": "EGR1 binds the PTEN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987120", "l": "JAK1 binds IFNLR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787737", "l": "CSF3R binds CSF3 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49996", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.28", "l": "\"cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34696", "l": "(2E,6E)-farnesyl diphosphate => Delta(6)-protoilludene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55571", "l": "4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine <=> 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23968", "l": "(E)-coniferaldehyde + H2O + NAD(+) = (E)-ferulate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879594", "l": "SLCO4C1 mediates the transport of digoxin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17750", "l": "A + H2O + quinoline => AH2 + quinolin-2(1H)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59470", "l": "an S-substituted L-cysteinylglycine + L-glutamate => an S-substituted glutathione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43057", "l": "5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH => 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374701", "l": "Phosphorylation of DCC by Fyn (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31915", "l": "ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.175", "l": "\"maltokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17233", "l": "L-fucose = L-fuculose", "d": []}, {"i": "EC:5.3.1.25", "l": "\"L-fucose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64925", "l": "dATP + 2 H2O => dAMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10583", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205319", "l": "Interaction of APS and p-KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21713", "l": "L-threo-3-phenylserine => benzaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373716", "l": "DCC interacting NCK-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35999", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24555", "l": "5alpha-cholestan-3-one + NADP(+) <=> cholest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56585", "l": "1,2-epoxypropane + H2O => propane-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5622129", "l": "FABP5 binds atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66784", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out) = 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36803", "l": "2-hydroxy-2,3-dihydrogenistein = genistein + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55769", "l": "all-trans-retinoate + UDP-alpha-D-glucuronate => all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804229", "l": "JMY, TTC5 and EP300 bind (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43776", "l": "an N-(acyl)-sphingosylphosphocholine(in) = an N-(acyl)-sphingosylphosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008473", "l": "ornithine cyclodeaminase activity", "d": ["Catalysis of the reaction: L-ornithine = L-proline + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16860", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine <=> an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14077", "l": "3-oxopropanoate + L-alanine = beta-alanine + pyruvate", "d": []}, {"i": "EC:2.6.1.18", "l": "\"beta-alanine--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928646", "l": "EPHAs bind EFNAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23928", "l": "H2O + N(8)-acetylspermidine = acetate + spermidine", "d": []}, {"i": "EC:3.5.1.48", "l": "\"acetylspermidine deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182986", "l": "CBL-mediated ubiquitination of CIN85 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430311", "l": "Rsu-1 interacts with Pinch1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52305", "l": "H2O + L-ectoine => (2S)-2-acetamido-4-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25514", "l": "chorismate + L-glutamine => (2S)-2-amino-4-deoxychorismate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40320", "l": "O2 + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950583", "l": "STAT3 binds to p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679044", "l": "FKBP1A binds sirolimus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67420", "l": "a glycerophospholipid + H2O = a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61351", "l": "ATP + estrone 3-sulfate(in) + H2O <=> ADP + estrone 3-sulfate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29165", "l": "2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out) => 2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602484", "l": "Activation of proMMP11 by FURIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55085", "l": "(3R)-3-hydroxypentanoyl-CoA + H2O => (3R)-3-hydroxypentanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2545253", "l": "Deacetylation of cohesin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53812", "l": "cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021357", "l": "PRKCI phosphorylates ELF3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166041", "l": "Transfer of LPS onto TLR4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67898", "l": "a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine => a 3'-end uridylyl-adenosine-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63318", "l": "9-hydroperoxy-(10E,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11539", "l": "choline + H2O + 2 O2 <=> glycine betaine + H(+) + 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49599", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-acyl-D-galactosylsphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952128", "l": "RUNX3 binds TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11844", "l": "acetyl-CoA + formate = CoA + pyruvate", "d": []}, {"i": "EC:2.3.1.54", "l": "\"formate C-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12584", "l": "16alpha-hydroxyprogesterone = 16,17-didehydroprogesterone + H2O", "d": []}, {"i": "EC:4.2.1.98", "l": "\"16alpha-hydroxyprogesterone dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70662", "l": "H(+)(in) + N,N-dimethylglycine(in) <=> H(+)(out) + N,N-dimethylglycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391872", "l": "NCAM1 cis-homophilic interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071164", "l": "RNA trimethylguanosine synthase activity", "d": ["Catalysis of two successive methyl transfer reactions from AdoMet to the N-2 atom of guanosine, thereby converting 7-methylguanosine in an RNA cap to 2,2,7 trimethylguanosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12572", "l": "(R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP = adenosylcob(III)inamide + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47909", "l": "6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O => 6-deoxy-6-sulfo-D-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395320", "l": "Latent TGF-beta-1 binds integrins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74920", "l": "a (2E)-2-fatty-enoyl-AMP + holo-[ACP] => a (2E)-enoyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191763", "l": "snRNP:Snurportin complex formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70131", "l": "3-dehydro-6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6-dehydro-28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63812", "l": "ATP + N(8)-citryl-spermidine + spermidine = AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420121", "l": "SFKs phosphorylate PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75734", "l": "(10S)-hydroxy-(12Z)-octadecenoate + NAD(+) <=> 10-oxo-(12Z)-octadecenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34112", "l": "carboxyspermidine + H2O + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632738", "l": "DDIT4 binds 14-3-3 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26391", "l": "all-trans-10'-apo-beta-carotenal + beta-ionone => all-trans-beta-carotene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668904", "l": "Formation of the CTF18 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6795667", "l": "MDM2 translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623192", "l": "G6PC gene expression is stimulated by FOXO1,FOXO3,FOXO4,FOXO6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63637", "l": "a medium-chain fatty acyl-AMP + holo-[ACP] => a medium-chain fatty acyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35565", "l": "(9Z)-hexadecenoate + ethanolamine => H2O + N-(9Z-hexadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9718020", "l": "PTGFR binds PTGFR agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611852", "l": "ADRB3 bind ADR,NAd (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43520", "l": "2-carboxy-5-(dihydroxymethyl)furan + O2 = 2,5-dicarboxyfuran + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682863", "l": "RNF168 binds DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57238", "l": "N(2)-(1-hydroxy-2-oxopropyl)-GMP => GMP + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27751", "l": "2'-deoxyinosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75238", "l": "TRAIL binds TRAIL receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47187", "l": "5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785047", "l": "IL10 positively regulates extracellular inflammatory mediators (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57089", "l": "an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000140", "l": "acylglycerone-phosphate reductase activity", "d": ["Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70010", "l": "anthranilate + ATP + H(+) <=> 2-aminobenzoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027632", "l": "5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75126", "l": "(1R)-(1-hydroxyethyl)phosphonate + O2 <=> acetate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21355", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 <=> (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5227009", "l": "ABCF1 binds EIF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33850", "l": "H2O + N-tetracosanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43894", "l": "[sulfur carrier]-SH + L-alanine => [sulfur carrier]-H + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940134", "l": "FOLR2 binds FOLA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38607", "l": "2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1458485", "l": "RALA hydrolyzes GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72631", "l": "Formation of the cap-binding eIF4F complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43313", "l": "ATP + N-(hexanoyl)sphing-4-enine => ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71304", "l": "chloride(out) + L-methionine(out) + 2 Na(+)(out) => chloride(in) + L-methionine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1369052", "l": "ABCAs mediate lipid influx (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16337", "l": "a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase] = a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.82", "l": "\"flavonoid 3'-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26169", "l": "3-fumarylpyruvate + H2O => fumarate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40112", "l": "butanoyl-CoA + H2O => butanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662606", "l": "MT3 binds zinc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67479", "l": "dimethylallyl diphosphate + L-glutamate <=> diphosphate + prekainate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624353", "l": "NR1H2,3 binds the PLTP gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50579", "l": "acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36187", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine = 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66158", "l": "CoA + H(+) + N-butanoyltyramine => butanoyl-CoA + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40231", "l": "(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0086075", "l": "gap junction channel activity involved in cardiac conduction electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12855", "l": "dhurrin + H(+) + UDP => (S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0046332", "l": "SMAD binding", "d": ["Binding to a SMAD signaling protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71917", "l": "2 Na(+)(in) + tauronorcholate(in) => 2 Na(+)(out) + tauronorcholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44047", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43446", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-ditetradecanoyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25990", "l": "albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (5R)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033509", "l": "USP9X binds Ub:PEX5L (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73547", "l": "GTP(out) + UTP(in) = GTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37382", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66008", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen] = [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43865", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31120", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA => (2E)-2-methylbut-2-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.4", "l": "\"adenosine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54554", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate => 1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34811", "l": "NADP(+) + tetrahydrocurcumin = dihydrocurcumin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796691", "l": "SPATA2 links CYLD to LUBAC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443783", "l": "Interaction of NUMB with L1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53907", "l": "ATP + L-threonyl-[tau protein] <=> ADP + H(+) + O-phospho-L-threonyl-[tau protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.130", "l": "\"3-dehydro-L-gulonate 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047427", "l": "cyanoalanine nitrilase activity", "d": ["Catalysis of the reaction: 3-cyano-L-alanine + 2 H2O + H+ = L-aspartate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43959", "l": "15-methylhexadecanoate + H(+) + NADPH + O2 <=> H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202702", "l": "CD177 binds PECAM-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18493", "l": "benzoyl-CoA + glycine = CoA + H(+) + N-benzoylglycine", "d": []}, {"i": "EC:2.3.1.71", "l": "\"glycine N-benzoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362522", "l": "ALDHs oxidise atRAL to atRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45924", "l": "9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2250301", "l": "Formation of lysyl-pyrrole cross-links (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16861", "l": "(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate", "d": []}, {"i": "EC:2.6.1.62", "l": "\"adenosylmethionine--8-amino-7-oxononanoate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11828", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)", "d": []}, {"i": "EC:3.1.4.58", "l": "\"RNA 2',3'-cyclic 3'-phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40056", "l": "1,2,3-trioctanoylglycerol + H2O => 2,3-dioctanoyl-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433804", "l": "IKK epsilon is recruited to the Viral dsRNA:TLR3:TICAM1 complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67848", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ATP + CoA = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39774", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-981713", "l": "C4b binds to cell surface (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22331", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) <=> diphosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66992", "l": "3-methylpentanoate + ATP + CoA = 3-methylpentanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63661", "l": "(8S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein] => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57970", "l": "8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018497", "l": "Estrogen-responsive TFF3 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18463", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10966", "l": "ADP + D-xylulose 5-phosphate + H(+) => ATP + D-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70503", "l": "H2O + isopentenyl diphosphate = H(+) + isopentenyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928617", "l": "EPHB2 binds KALRN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16867", "l": "3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA => choloyl-CoA + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420202", "l": "Secretin receptor binds secretin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65434", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+) => a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15297", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.133", "l": "\"xylosylprotein 4-beta-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433395", "l": "Dimerization of sSCF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46782", "l": "a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352059", "l": "SLC6A15-mediated amino acid uptake (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-179421", "l": "Degradation of multiubiquitinated Nek2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050164", "l": "oxoglutarate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + CoA + NADP+ = CO2 + NADPH + succinyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014293", "l": "RAC2 GDIs block activation of RAC2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33096", "l": "chorismate + inosine + phosphoenolpyruvate => futalosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202713", "l": "CD84 homodimerises (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19945", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}, {"i": "EC:2.4.1.201", "l": "\"alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34284", "l": "2 L-tyrosine + O2 => 2 L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31216", "l": "(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) => (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50393", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + oxytetracycline => 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10587", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH <=> 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21307", "l": "ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11647", "l": "a (2R,3R)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936851", "l": "AHRR binds ARNT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37962", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14288", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose <=> 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42214", "l": "a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654511", "l": "FGFRL1 dimer binds FGFs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102874", "l": "1-16:0-2-18:2-digalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-16:0-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.56", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429767", "l": "Passive I- efflux mediated by SMCT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66862", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate => dimethylallyl diphosphate + 4 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.116661854742532", "identifiers": [{"i": "GO:0032393", "l": "MHC class I receptor activity", "d": ["Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75487", "l": "dehydroepiandrosterone 3-sulfate(out) + n H(+)(out) = dehydroepiandrosterone 3-sulfate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805470", "l": "AMPK phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40423", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52652", "l": "lanosterol + S-adenosyl-L-methionine = eburicol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669023", "l": "TWEAK binds FN14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047303", "l": "glycine-oxaloacetate transaminase activity", "d": ["Catalysis of the reaction: glycine + oxaloacetate = L-aspartate + glyoxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51997", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] => a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000515", "l": "aspartate:glutamate, proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-aspartate(in) + L-glutamate(out) = H+(in) + L-aspartate(out) + L-glutamate(in)."]}, {"i": "RHEA:70783", "l": "H(+)(out) + L-aspartate(in) + L-glutamate(out) = H(+)(in) + L-aspartate(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26281", "l": "Co-precorrin-5A + H2O = acetaldehyde + Co-precorrin-5B + H(+)", "d": []}, {"i": "EC:3.7.1.12", "l": "\"cobalt-precorrin 5A hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65456", "l": "2-methylbutan-1-ol + acetyl-CoA = 2-methylbutyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21152", "l": "trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline", "d": []}, {"i": "EC:5.1.1.8", "l": "\"4-hydroxyproline epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75030", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + 9-hydroxy-octadecanoate <=> 9-(9Z-hexadecenoyloxy)-octadecanoate + di-(9Z)-hexadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17556", "l": "ATP + guanidinoethyl methyl phosphate <=> ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165680", "l": "Formation of active mTORC1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40417", "l": "2,6,10,14-tetramethylpentadecanoate + CoA + H(+) => H2O + pristanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22948", "l": "D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": []}, {"i": "EC:4.1.2.40", "l": "\"tagatose-bisphosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56574", "l": "globoside Gb3Cer + H(+) + UDP => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947535", "l": "Cyclisation of GTP to precursor Z (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34159", "l": "acetyl-CoA + UDP-N-acetylbacillosamine = CoA + H(+) + UDP-N,N'-diacetylbacillosamine", "d": []}, {"i": "EC:2.3.1.203", "l": "\"UDP-N-acetylbacillosamine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944236", "l": "Association of procollagen type XIV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55354", "l": "13-cis-retinol => all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114671", "l": "vWF binds to collagen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30275", "l": "AH2 + H2O2 = A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66778", "l": "ADP + H(+) + phosphate + uroporphyrin III(out) => ATP + H2O + uroporphyrin III(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015333", "l": "peptide:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508513", "l": "PTK2B binds JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008664", "l": "2'-5'-RNA ligase activity", "d": ["Catalysis of the formation of a phosphodiester bond between the 2'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61872", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 = 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483087", "l": "PI is exchanged with PC by PITPNB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75602", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> ectocarpin A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72567", "l": "dehydroepiandrosterone 3-sulfate(in) + propanoate(out) = dehydroepiandrosterone 3-sulfate(out) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48925", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E)) => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18037", "l": "agmatine + H2O = N-carbamoylputrescine + NH4(+)", "d": []}, {"i": "EC:3.5.3.12", "l": "\"agmatine deiminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51135", "l": "a purine 2'-deoxyribonucleoside 5'-phosphate + H2O <=> 2-deoxy-D-ribose 5-phosphate + a purine nucleobase", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68153", "l": "a 1,3-diacylglycerol + a fatty acyl-CoA => a triacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49631", "l": "acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine <=> 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17846", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) => 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57500", "l": "3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371590", "l": "HSP70 binds to HSP40:nascent protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47666", "l": "2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17258", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vinorine => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39724", "l": "a 1,2-diacyl-sn-glycerol(in) => a 1,2-diacyl-sn-glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14031", "l": "AH2 + selenate => A + H2O + selenite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63503", "l": "H(+) + NADPH + S-nitrosoglutathione <=> NADP(+) + sulfinamide glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73476", "l": "D-arginine(in) + L-ornithine(out) => D-arginine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170011", "l": "stalled ribosome sensor activity", "d": ["A molecule that recognizes stalled ribosomes and initiates a signalling response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903135", "l": "cupric ion binding", "d": ["Binding to a cupric ion, copper(2+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73637", "l": "CTP(in) + dGMP(out) => CTP(out) + dGMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10824", "l": "(S)-malate + NADP(+) = H(+) + NADPH + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44302", "l": "4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70066", "l": "a C28-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a (22S)-22-hydroxy C28-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64446", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36503", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351871", "l": "Caspase-mediated cleavage of Z0-2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30262", "l": "2 a menaquinol + O2 <=> 2 a menaquinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-517705", "l": "p-S318,221-HuR binds mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396401", "l": "NOTCH1 PEST domain mutants bind HES5 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26319", "l": "3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate => 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.136", "l": "\"gallate 1-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34429", "l": "(-)-pinoresinol + H(+) + NADPH => (-)-lariciresinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174916", "l": "Formation of N-glucuronides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75879", "l": "Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) + L-proline betaine = methyl-Co(III)-[quaternary-amine-specific corrinoid protein] + N-methyl-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13675", "l": "[protein-PII]-uridylyl-L-tyrosine + diphosphate => [protein-PII]-L-tyrosine + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022065", "l": "DSPGs are secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200396", "l": "Creatine transport across the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58814", "l": "AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901612", "l": "cardiolipin binding", "d": ["Binding to cardiolipin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14844", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033995", "l": "anhydrosialidase activity", "d": ["Catalysis of the reaction: an N-acetylneuraminate glycoside = 2,7-anhydro-alpha-N-acetylneuraminate + an alpha-sialyl group. This reaction is the elimination of alpha-sialyl groups in N-acetylneuraminic acid glycosides, releasing 2,7-anhydro-alpha-N-acetylneuraminate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198813", "l": "GSTO dimers reduce DeHA to AscH- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35518", "l": "4'''-demalonylsalvianin + malonyl-CoA <=> CoA + salvianin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45012", "l": "H2O + N-octadecanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.054311793581761", "identifiers": [{"i": "GO:0043891", "l": "glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2399913", "l": "atRAL binds to RBP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296301", "l": "CCRL2 binds CCL19 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169895", "l": "Crk's SH3 domain engages C3G (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5140741", "l": "WNT5A binds FZD and ROR receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797810", "l": "PTPRD binds IL1RAPL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111930", "l": "Adenylate cyclase produces cAMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10898", "l": "2 H(+) + limonoate => 2 H2O + limonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399939", "l": "Autophosphorylation of PAK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32828", "l": "ATP + H2O + methionine(out) => ADP + H(+) + methionine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38794", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981621", "l": "Neuroglobin:oxygen dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16888", "l": "2 bilirubin-glucuronoside <=> bilirubin IXalpha + bilirubin-bisglucuronoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19804", "l": "(R)-4'-phosphopantetheine + ATP + H(+) <=> 3'-dephospho-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53714", "l": "beta-hematin => 2 Fe(III)-heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54170", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64128", "l": "H2O + N-octadecanoyl-L-phenylalanine = L-phenylalanine + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35954", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate <=> diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62384", "l": "cyclic (2R)-2,3-bisphosphoglycerate + H2O = (2R)-2,3-bisphosphoglycerate + 2 H(+)", "d": []}, {"i": "EC:3.1.4.61", "l": "\"cyclic 2,3-diphosphoglycerate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169192", "l": "PTP1B dephosphorylates GHR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47892", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418456", "l": "cGMP is degraded by PDEs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1370505", "l": "PRLR is phosphorylated at Ser-349 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57206", "l": "N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] => glyoxal + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22726", "l": "a sterol 3-beta-D-glucoside + H(+) + UDP => a sterol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63680", "l": "(7R,8S)-7,8-diammoniononanoate + CO2 = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0016793", "l": "triphosphoric monoester hydrolase activity", "d": ["Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139914", "l": "Translocation of BBC3 (PUMA) protein to mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67901", "l": "glutarate + succinyl-CoA => glutaryl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42930", "l": "H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine => cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033705", "l": "GDP-4-dehydro-6-deoxy-D-mannose reductase activity", "d": ["Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047735", "l": "cellobiose dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084912", "l": "Arresten binds integrin alpha1beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.3.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003949", "l": "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity", "d": ["Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43510", "l": "2-(dihydroxymethyl)-5-formylfuran => 2,5-diformylfuran + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52540", "l": "cytidine + phosphate = alpha-D-ribose 1-phosphate + cytosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047813", "l": "D-arabinitol 4-dehydrogenase activity", "d": ["Catalysis of the reaction: D-arabinitol + NAD+ = D-xylulose + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68621", "l": "cortisone + H(+) + NADPH => 20beta-dihydrocortisone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952419", "l": "SMURFs ubiquitinate RUNX3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72904", "l": "butyrolactone II + dimethylallyl diphosphate => butyrolactone I + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047538", "l": "2-carboxy-D-arabinitol-1-phosphatase activity", "d": ["Catalysis of the reaction: 2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74488", "l": "anthranilate + 2 ATP + O-methyl-L-tyrosine + S-adenosyl-L-methionine => (-)-4'-methoxycyclopeptine + 2 AMP + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031756", "l": "Edg-3 sphingosine 1-phosphate receptor binding", "d": ["Binding to an Edg-3 sphingosine 1-phosphate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37772", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051373", "l": "FATZ binding", "d": ["Binding to a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0032131", "l": "alkylated DNA binding", "d": ["Binding to an alkylated residue in DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49211", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004698", "l": "calcium-dependent protein kinase C activity", "d": ["Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.30", "l": "\"D-psicose 3-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35386", "l": "precorrin-6B + S-adenosyl-L-methionine <=> CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58710", "l": "rifampicin para-naphthoquinone carboxamide => rifampicin ortho-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801675", "l": "PLK2 phosphorylates NPM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247497", "l": "ERBB3 binds neuregulins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372819", "l": "PCK2 phosphorylates OA to yield PEP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34073", "l": "N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP => trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75468", "l": "ethanolamine(out) + n H(+)(in) => ethanolamine(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38505", "l": "a 1-acyl-sn-glycerol + a fatty acid + H(+) => 1,3-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55226", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606564", "l": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034836", "l": "6-hydroxy-2-mercaptobenzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: 6-hydroxy-2-mercaptobenzothiazole + 1/2 O2 = 6,7-dihydroxy-2-mercaptobenzothiazole."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050640", "l": "isopenicillin-N N-acyltransferase activity", "d": ["Catalysis of the reaction: phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75490", "l": "dehydroepiandrosterone 3-sulfate(out) + n H(+)(out) <=> dehydroepiandrosterone 3-sulfate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17193", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": []}, {"i": "EC:3.1.3.66", "l": "\"phosphatidylinositol-3,4-bisphosphate 4-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23084", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 7-methyl-3-oxooct-6-enoyl-CoA + acetate", "d": []}, {"i": "EC:4.1.3.26", "l": "\"3-hydroxy-3-isohexenylglutaryl-CoA lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17806", "l": "H2O + S-adenosyl-L-homocysteine => adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32751", "l": "choline(out) = choline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205321", "l": "Interaction of KIT and sSCF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140441", "l": "protein-cysteine S-arachidonoyltransferase activity", "d": ["Catalysis of the transfer of an arachidonoyl (systematic name, (5Z,8Z,11Z,14Z)-eicosatetraenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: in the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]."]}, {"i": "RHEA:59748", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21866", "l": "a 2-hydroxy carboxylate + glutathione + H(+) => an S-(2-hydroxyacyl)glutathione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56160", "l": "an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate = an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.356", "l": "\"glucosyl-dolichyl phosphate glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36022", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12776", "l": "2-oxoglutarate + O2 + proclavaminate <=> CO2 + dihydroclavaminate + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38974", "l": "O2 + octadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59982", "l": "8-oxo-dGDP + H(+) + phosphate => 8-oxo-dGTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20544", "l": "H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 <=> 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43117", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37933", "l": "(10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018505", "l": "cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19800", "l": "1D-myo-inositol 1,4,5-trisphosphate + H2O <=> 1D-myo-inositol 1,4-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847977", "l": "FRK phosphorylates PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-205136", "l": "GTP-bound RAC contributes to JNK activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46308", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52137", "l": "a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O => a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21763", "l": "(3S)-3-hydroxybutanoyl-CoA <=> (3R)-3-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163691", "l": "Phosphorylation of ChREBP at Serine 556 by AMPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48290", "l": "CMP + ganglioside GD3 + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60942", "l": "(9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42327", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-L-Glu)(n) <=> 3 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090710", "l": "phosphomevalonate decarboxylase activity", "d": ["Catalysis of the reaction: ATP + (R)-mevalonate 5-phosphate = ADP + isopentenyl phosphate + CO2 + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48061", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035800", "l": "deubiquitinase activator activity", "d": ["Binds to and increases the activity of a deubiquitinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52330", "l": "H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin] => L-arginine + O2 + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201669", "l": "Beta-catenin translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31683", "l": "prosolanapyrone III = (-)-solanapyrone A", "d": []}, {"i": "EC:5.5.1.20", "l": "\"prosolanapyrone-III cycloisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13004", "l": "1D-myo-inositol hexakisphosphate + H2O <=> 1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75043", "l": "L-cystine(out) + L-leucine(in) = L-cystine(in) + L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034955", "l": "2,3-dihydroxydiphenyl ether dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxydiphenyl ether + O2 + H2O = 2-hydroxymuconate + phenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613497", "l": "Unwinding DNA for the nascent transcript (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202466", "l": "Interaction of Bcl10 to CARMA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632652", "l": "Hh-Npp binds CDON and PTCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67056", "l": "chermesin D + S-adenosyl-L-methionine = chermesin D methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166284", "l": "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55634", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+) => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.850028330009977", "identifiers": [{"i": "GO:0008092", "l": "cytoskeletal protein binding", "d": ["Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110322", "l": "Formation of Pol zeta complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028583", "l": "Phosphorylation of YAP by LATS2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47627", "l": "cis-3-hydroxy-L-proline <=> 1-pyrroline-2-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14001", "l": "choloyl-CoA + glycine = CoA + glycocholate + H(+)", "d": []}, {"i": "EC:2.3.1.65", "l": "\"bile acid-CoA:amino acid N-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35450", "l": "(1'S)-averantin + NADP(+) <=> H(+) + NADPH + norsolorinic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28937", "l": "oxaloacetate + pyruvate => 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-421835", "l": "trans-Golgi Network Vesicle Scission (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51189", "l": "nitric oxide + superoxide => peroxynitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684017", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16091", "l": "ethanolamine + phosphate => H2O + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42408", "l": "(2R)-2-phosphoglycerate + ATP = (2R)-2,3-bisphosphoglycerate + ADP + H(+)", "d": []}, {"i": "EC:2.7.2.16", "l": "\"2-phosphoglycerate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65689", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940554", "l": "MMP2 cleaves OPTC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54097", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983152", "l": "Transfer of ubiquitin from E1 to E2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678920", "l": "TLR processing at low pH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22086", "l": "2 NH4(+) + pyruvate => (S)-2,3-diaminopropanoate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19538", "l": "D-mannitol 1-phosphate + H2O => D-mannitol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624956", "l": "PDE6D binds INPP5E (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71916", "l": "2 Na(+)(out) + tauronorcholate(out) => 2 Na(+)(in) + tauronorcholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32550", "l": "(2E)-geranyl diphosphate <=> (1R,5R)-sabinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784434", "l": "An unknown carrier transports cytosolic glyoxylate to the peroxisome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507869", "l": "Aquaporins passively transport glycerol into cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35279", "l": "acetyl-CoA + hexadecanoyl-CoA = 3-oxooctadecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26287", "l": "Co-precorrin-6A + S-adenosyl-L-homocysteine => Co-precorrin-5B + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665304", "l": "ERBB2 T862A does not bind sapitinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64264", "l": "atrochrysone carboxylate + H(+) = atrochrysone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "60.902216582032437", "identifiers": [{"i": "GO:0016810", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds", "d": ["Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29799", "l": "ATP + D-allose(out) + H2O = ADP + D-allose(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.5.2.8", "l": "\"ABC-type D-allose transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685607", "l": "Sialic acid binds SIGLEC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24362", "l": "Fe(2+) + sirohydrochlorin => 2 H(+) + siroheme", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15478", "l": "3'-phosphoadenylyl sulfate + 5beta-scymnol => 5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45499", "l": "phycocyanobilin-L-cysteinyl(84)-[allophycocyanin alpha-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909738", "l": "SHP1 and SHP2 bind the common beta chain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51873", "l": "dimethylallyl diphosphate + umbelliferone => diphosphate + osthenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675206", "l": "PEA15 binds MAPK monomers and dimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877404", "l": "RUNX1 binds the promoter of the CTLA4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50841", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54438", "l": "a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate => 2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654510", "l": "FGFRL1 binds SPRED1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188345", "l": "The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14635", "l": "ADP + H(+) + Na(+)(out) + phosphate => ATP + H2O + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31364", "l": "NADP(+) + reduced coenzyme F420-(gamma-L-Glu)(n) => 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75686", "l": "(12R,13S)-epoxy-(9Z)-octadecenoate + O2 <=> (12R,13S)-epoxy-(10R)-hydroperoxy-(8E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785762", "l": "IL13RA1 binds TYK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42755", "l": "pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632182", "l": "PRMT1 methylates ESRs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018740", "l": "2'-hydroxybiphenyl-2-sulfinate desulfinase activity", "d": ["Catalysis of the reaction: 2'-hydroxybiphenyl-2-sulfinate + H2O = biphenyl-2-ol + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514831", "l": "Fibrillin-1 degradation by MMP14 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9732527", "l": "FFAR1 binds rosiglitazone (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26082", "l": "(2E,6E)-farnesyl diphosphate => (Z)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23538", "l": "alpha-D-glucose 6-phosphate => alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31167", "l": "(3S)-hydroxytetradecanoyl-CoA + NAD(+) = 3-oxotetradecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0004449", "l": "isocitrate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696266", "l": "RND2 binds effectors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73510", "l": "7,8-dihydroxyflavone + S-adenosyl-L-methionine <=> 7-hydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18188", "l": "adenosine + O2 <=> 5'-dehydroadenosine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.535054500181104", "identifiers": [{"i": "GO:0017022", "l": "myosin binding", "d": ["Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11404", "l": "UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate", "d": []}, {"i": "EC:5.1.3.6", "l": "\"UDP-glucuronate 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65859", "l": "A + a 1-hydroxy-3-oxo steroid <=> a steroid 1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444647", "l": "C3a receptor binds anaphylatoxin C3a (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24521", "l": "H2O + L-saccharopine + NAD(+) => (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32582", "l": "(2E)-geranyl diphosphate <=> (1R,5R)-beta-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851919", "l": "Activated MET binds GAB1 and GRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61709", "l": "holo-[peptidyl-carrier protein] + L-seryl-5'-AMP => AMP + L-seryl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69813", "l": "6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54228", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine = 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52730", "l": "a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32362", "l": "1D-myo-inositol 1,4,5-trisphosphate + 2 ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-481007", "l": "Exocytosis of platelet alpha granule contents (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389352", "l": "Translocation of Vav1 to CD28 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12714", "l": "a nucleoside 5'-phosphate + ATP => a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74230", "l": "H2O + L-threonyl-tRNA(Ile) <=> L-threonine + tRNA(Ile)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809521", "l": "BPIF binds bacteria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66585", "l": "3-oxocholestane + A + H2O => 25-hydroxy 3-oxocholestane + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004765", "l": "shikimate kinase activity", "d": ["Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72441", "l": "(E)-feruloyl-AMP + diphosphate => (E)-ferulate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27678", "l": "ATP + dCDP = ADP + dCTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35992", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69695", "l": "H(+) + menadione + NADH = menadiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16816", "l": "H2O + L-kynurenine <=> anthranilate + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18391", "l": "diphosphate + UDP-alpha-D-xylose => alpha-D-xylose 1-phosphate + H(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299359", "l": "Activation of TALK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236970", "l": "Proteasomal clevage of exogenous antigen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13973", "l": "diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate", "d": []}, {"i": "EC:7.1.3.1", "l": "\"H(+)-exporting diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47947", "l": "(2E)-geranyl diphosphate + H2O <=> (2E)-geranyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32531", "l": "4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = alpha-D-mannose 1-phosphate + D-glucose", "d": []}, {"i": "EC:2.4.1.281", "l": "\"4-O-beta-D-mannosyl-D-glucose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58131", "l": "A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine <=> AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936380", "l": "Interaction of PIN1 with p-IRF3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24391", "l": "phosphate + uridine <=> alpha-D-ribose 1-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61132", "l": "(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + kaempferol + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50023", "l": "decanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42037", "l": "chenodeoxycholate + NAD(+) => 7-oxolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42073", "l": "(4Z)-2-oxohept-4-enedioate + H2O => (4S)-4-hydroxy-2-oxoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50177", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53759", "l": "allodeoxycholoyl-CoA + cholate <=> allodeoxycholate + choloyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75908", "l": "ADP-L-glycero-beta-D-manno-heptose + L-seryl-[protein] => ADP + H(+) + O-(L-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61629", "l": "5-aminopentanal => 1-piperideine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56321", "l": "a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose => an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63071", "l": "acetyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 2 CO2 + 3 CoA + triacetate lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32177", "l": "alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+) => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168638", "l": "Activated IKK phosphorylates I-kappaB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-844447", "l": "NLRP1 senses MDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.115", "l": "\"infectious pancreatic necrosis birnavirus Vp4 peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944254", "l": "Association of procollagen type XXVI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65632", "l": "a sphingoid base + tetracosanoyl-CoA = an N-tetracosanoyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12505", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) => 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71495", "l": "6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141035", "l": "CTP-dependent diacylglycerol kinase activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + CTP = a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944454", "l": "mTORC1 phosphorylates MAF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17950", "l": "3-hydroxy-1H-quinolin-4-one + O2 => CO + H(+) + N-formylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9769235", "l": "MAGED1 binds NPAS4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29408", "l": "2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2 => 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27830", "l": "neryl diphosphate = beta-phellandrene + diphosphate", "d": []}, {"i": "EC:4.2.3.51", "l": "\"beta-phellandrene synthase (neryl-diphosphate-cyclizing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47527", "l": "cholate + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024159", "l": "FTSJ1 2'-O-methylates cytidine-32 in tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199093", "l": "CXADR binds to AMICA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163770", "l": "Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71507", "l": "(+)-alpha-tocopherol(out) = (+)-alpha-tocopherol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39305", "l": "(2E,11Z,14Z)-eicosatrienoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36140", "l": "(E)-hexadec-2-enoate + ATP + CoA => (2E)-hexadecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39889", "l": "H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin => 2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389083", "l": "Autophosphorylation of PDGF alpha receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850534", "l": "PDCL promotes G-protein beta 5 folding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671993", "l": "CIT-3 binds DLG4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18050", "l": "2-oxoglutarate + N(2)-acetyl-L-ornithine => L-glutamate + N-acetyl-L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18483", "l": "cyclohexylamine + sulfate => cyclohexylsulfamate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371527", "l": "HSF1 trimer translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190520", "l": "Association of Golgi  transport vesicles with microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654573", "l": "Activated FGFR1 binds SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814088", "l": "SYS1 binds AcM-ARFRP1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72356", "l": "dehydroepiandrosterone 3-sulfate(out) + glutarate(in) => dehydroepiandrosterone 3-sulfate(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39704", "l": "(2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH => (13Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44928", "l": "2-oxoheptanedioate + acetyl-CoA + H2O = (R)-trihomocitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42472", "l": "dibenzo-p-dioxin + NADH + O2 = 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54393", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33928", "l": "4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 => 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952996", "l": "E2F7 forms homodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61699", "l": "ATP + glycine + holo-[peptidyl-carrier protein] <=> AMP + diphosphate + glycyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706344", "l": "FLT3 phosphorylates GRB10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008774", "l": "acetaldehyde dehydrogenase (acetylating) activity", "d": ["Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.1.3", "l": "\"hydrogen dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44231", "l": "9-decenoate + ATP + CoA <=> 9-decenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43677", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008147", "l": "structural constituent of bone", "d": ["The action of a molecule that contributes to the structural integrity of bone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14606", "l": "D-glucose 6-phosphate + GDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48027", "l": "1,2,3-tripropanoylglycerol + H2O <=> dipropanoylglycerol + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70982", "l": "Fumarate + H2O <=> (S)-Malate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210289", "l": "Recruitment of SYK to p-DAP12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40302", "l": "6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679266", "l": "Beclin-1 complex translocates to the ER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796368", "l": "RIPK1 binds STUB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45751", "l": "(3Z)-hexenoyl-CoA <=> (2E)-hexenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28403", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56031", "l": "3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374663", "l": "DCC interaction with Ezrin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17904", "l": "S-adenosyl-L-methionine + xanthotoxol <=> H(+) + S-adenosyl-L-homocysteine + xanthotoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607744", "l": "MALT1 binds BCL10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40115", "l": "H2O + hexanoyl-CoA = CoA + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14671", "l": "(2R)-3-phosphoglycerate + 2 H(+) + NADPH => D-glyceraldehyde 3-phosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617820", "l": "Assembly of IFT B complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430135", "l": "p-SLP-76 binds ADAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166542", "l": "beta-NGF dimer binds to TrkA receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40763", "l": "(20S)-ginsenoside Re + H2O = (20S)-ginsenoside Rg1 + L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33255", "l": "2-demethylmenaquinol-7 + S-adenosyl-L-methionine = H(+) + menaquinol-7 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65436", "l": "a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+) = a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate", "d": []}, {"i": "EC:2.7.7.88", "l": "\"GDP polyribonucleotidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66197", "l": "acetyl-CoA + tryptamine => CoA + H(+) + N-acetyltryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853405", "l": "TPX2 binds AURKA at centrosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784959", "l": "BPHL hydrolyses VACV to ACV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14526", "l": "A + beta-cyclopiazonate => AH2 + alpha-cyclopiazonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37951", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34088", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol => a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74119", "l": "delphinidin + UDP-alpha-D-galactose = delphinidin 3-O-beta-D-galactoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45107", "l": "6-demethylmitomycin A + S-adenosyl-L-methionine <=> mitomycin A + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430311", "l": "Rsu-1 interacts with Pinch1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018114", "l": "threonine racemase activity", "d": ["Catalysis of the reaction: L-threonine = D-threonine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047830", "l": "D-octopine dehydrogenase activity", "d": ["Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806732", "l": "GNLY binds the bacterial cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24767", "l": "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate <=> UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53290", "l": "5-dehydro-L-gluconate + H(+) => 3-dehydro-scyllo-inosose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52902", "l": "15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate => 3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24261", "l": "(3E)-2-oxohex-3-enedioate + H(+) => 2-oxopent-4-enoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186780", "l": "PI3-kinase binds to the active receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654651", "l": "Activated FGFR4 binds FRS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75696", "l": "2'-deoxycytidine(in) => 2'-deoxycytidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40535", "l": "4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59973", "l": "decanoyl-CoA + L-seryl-[protein] => CoA + O-decanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59994", "l": "(E)-4-coumarate + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + phloretate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018754", "l": "GDIs bind RHOH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24883", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) => H(+) + L-glutamate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35829", "l": "spermidine + urea => H2O + N(1)-aminopropylagmatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16214", "l": "3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32338", "l": "(1S,2S,4R)-endo-fenchol + NADP(+) <=> (1S,4R)-fenchone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0005350", "l": "pyrimidine nucleobase transmembrane transporter activity", "d": ["Enables the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28661", "l": "beta-D-galactose + beta-D-glucose => beta-lactose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161666", "l": "PGA2 is isomerised to PGC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32620", "l": "L-threo-7,8-dihydrobiopterin + NADP(+) => H(+) + NADPH + sepiapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21876", "l": "(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) = (S)-usnate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.1.1.199", "l": "\"(S)-usnate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005344", "l": "oxygen carrier activity", "d": ["Binding to oxygen and delivering it to an acceptor molecule or a specific location."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626228", "l": "The distal appendage proteins recruit TTBK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10555", "l": "D-glucose + O2 <=> 2-dehydro-D-glucose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44281", "l": "2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA => 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22974", "l": "butanoyl-CoA + H(+) + NADPH => butanal + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0010178", "l": "IAA-amino acid conjugate hydrolase activity", "d": ["Catalysis of the cleavage of the amide bond between IAA (auxin) and the conjugated amino acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103064", "l": "inositol phosphorylceramide mannosyltransferase activity", "d": ["Catalysis of the reaction: a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1,6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58678", "l": "H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide => NADPH + O2 + rifamycin SV", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051266", "l": "sirohydrochlorin ferrochelatase activity", "d": ["Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22984", "l": "carbamoyl phosphate + oxamate = N-carbamoyl-2-oxoglycine + phosphate", "d": []}, {"i": "EC:2.1.3.5", "l": "\"oxamate carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753634", "l": "GGT dimers hydrolyse APAP-SG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41899", "l": "(2E)-tetradecenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65701", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] => cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008934", "l": "inositol monophosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16587", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin] => [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028583", "l": "Phosphorylation of YAP by LATS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72489", "l": "citrate(in) + phosphoenolpyruvate(out) => citrate(out) + phosphoenolpyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41876", "l": "(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69157", "l": "spermine dialdehyde => acrolein + N-(4-aminobutyl)-3-aminopropanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0015423", "l": "ABC-type maltose transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710106", "l": "ELANE cleaves GSDMD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61580", "l": "(3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+) = (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50327", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202111", "l": "AKT1 phosphorylates eNOS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25917", "l": "A + H2O + quinolin-6-ol => 6-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864395", "l": "TFAP2A,TFAP2C homodimers stimulate ESR1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336421", "l": "DT fragment A ADP-ribosylates target cell EEF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786650", "l": "DDHD1,2 hydrolyse PA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74718", "l": "Internalisation of the insulin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63592", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34072", "l": "trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22876", "l": "(R)-mandelamide + H2O = (R)-mandelate + NH4(+)", "d": []}, {"i": "EC:3.5.1.86", "l": "\"mandelamide amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40740", "l": "(20S)-ginsenoside Rb2 + 2 H2O => (20S)-ginsenoside C-Y + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166015", "l": "Association of LBP with LPS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60258", "l": "AH2 + formaldehyde + L-lysyl(4)-[histone H3] => A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42955", "l": "cytidine(49) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54101", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61383", "l": "2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O <=> 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950782", "l": "p-STAT1 binds p-STAT3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20125", "l": "H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20047", "l": "2 H(+) + malonate + NADH => 3-oxopropanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042978", "l": "ornithine decarboxylase activator activity", "d": ["Binds to and increases ornithine decarboxylase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35700", "l": "(S)-versiconol + NADP(+) => (2S-3S)-versiconal hemiacetal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31315", "l": "(2R)-3-phosphoglycerate + GDP-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392834", "l": "Activation of EPACs by cAMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14538", "l": "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O => 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019772", "l": "low-affinity IgG receptor activity", "d": ["Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16864", "l": "(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine <=> (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44698", "l": "a fatty acid + H(+) + sn-glycerol 3-phosphocholine => a 2-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70820", "l": "L-homoarginine(in) + L-ornithine(out) => L-homoarginine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44207", "l": "2-hydroxyhexadecanoate + ATP + CoA <=> 2-hydroxyhexadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706350", "l": "FLT3 phosphorylates CBL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59782", "l": "(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine => L-histidine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61977", "l": "glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine => 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34869", "l": "AMP + diphosphate + thiophene-2-carbonyl-CoA => ATP + CoA + thiophene-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17026", "l": "NADP(+) + xylitol => H(+) + L-xylulose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985943", "l": "p-Y701-STAT1 dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68219", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1,2-dihexanoylglycerol <=> 1,2-dihexanoyl-3-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9659820", "l": "RB1 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013147", "l": "RAC1 GDIs block activation of RAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28077", "l": "(2R)-3-sulfopropanediol + H2O + 2 NAD(+) <=> (2R)-3-sulfolactate + 3 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56968", "l": "dCTP + pyruvate = dCDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54670", "l": "alpha-onocerin => pre-alpha-onocerin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69068", "l": "RFC dissociates after sliding clamp formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.99", "l": "\"spermosin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67763", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199425", "l": "PHLPP dephosphorylates S473 in AKT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0001640", "l": "adenylate cyclase inhibiting G protein-coupled glutamate receptor activity", "d": ["Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664879", "l": "ATM:PEX5 binds ATM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66897", "l": "4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167072", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24907", "l": "L-tyrosine => (E)-4-coumarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15544", "l": "DIMBOA + UDP-alpha-D-glucose <=> DIMBOA beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57049", "l": "AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694364", "l": "N-glycan glucose trimming of Spike (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48140", "l": "2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] = 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite", "d": []}, {"i": "EC:1.14.15.17", "l": "\"pheophorbide a oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75590", "l": "11-O-acetylcyathatriol + UDP-alpha-D-glucose <=> erinacine Q2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43481", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019914", "l": "cyclin-dependent protein kinase activating kinase regulator activity", "d": ["Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44803", "l": "1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-6 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981606", "l": "Myoglobin binds oxygen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062076", "l": "acyl-CoA delta5-desaturase activity", "d": ["Catalysis of the reaction: (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA) and add a fourth double bond (a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352059", "l": "SLC6A15-mediated amino acid uptake (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57498", "l": "2-methyl-cis-aconitate + H2O => 2-methylcitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2545196", "l": "FN1 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664879", "l": "ATM:PEX5 binds ATM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17397", "l": "a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.100", "l": "\"3-oxoacyl-[acyl-carrier-protein] reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114256", "l": "CYCS:APAF1 binds procaspase-9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18506", "l": "L-lysine + NAD(+) => Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678925", "l": "NR3C1 binds NR3C1 agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982645", "l": "GRKs bind ADRB2:Catecholamine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28129", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose <=> alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73152", "l": "CoA(out) + FMN(in) => CoA(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5225649", "l": "RBBP7 binds histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685318", "l": "BCDX2 complex formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54640", "l": "(+)-copalyl diphosphate = (12E)-labda-8(17),12,14-triene + diphosphate", "d": []}, {"i": "EC:4.2.3.193", "l": "\"(12E)-labda-8(17),12,14-triene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22684", "l": "4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 = (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O", "d": []}, {"i": "EC:1.14.99.65", "l": "\"4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651828", "l": "PARG dePARylates PARP1,PARP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696274", "l": "RND1 binds GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2327746", "l": "FN1 aggregation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9615348", "l": "AGT(34-41) binds to AGTR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38368", "l": "8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA => 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005019", "l": "platelet-derived growth factor beta-receptor activity", "d": ["Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23224", "l": "trans-zeatin + UDP-alpha-D-glucose = H(+) + O-beta-D-glucosyl-trans-zeatin + UDP", "d": []}, {"i": "EC:2.4.1.203", "l": "\"trans-zeatin O-beta-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29288", "l": "2 H(+)(in) + L-aspartate(in) => 2 H(+)(out) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28777", "l": "H(+) + H2O + hnu + oxidized dinoflagellate luciferin => dinoflagellate luciferin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47114", "l": "glycochenodeoxycholate + H2O => chenodeoxycholate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32411", "l": "(1R,2R,4S)-isodihydrocarveol + NAD(+) = (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39174", "l": "3-oxoeicosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyeicosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66945", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34047", "l": "6'''-deamino-6'''-hydroxyneomycin C + O2 = 6'''-deamino-6'''-oxoneomycin C + H2O2", "d": []}, {"i": "EC:1.1.3.44", "l": "\"6'''-hydroxyneomycin C oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19954", "l": "a 2-oxocarboxylate + L-alanine => an L-alpha-amino acid + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709406", "l": "CO binds to Cytochrome c oxidase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25905", "l": "futalosine + H2O => dehypoxanthine futalosine + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0061791", "l": "GTPase motor activity", "d": ["A motor activity driven by GTP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42063", "l": "11-cis-retinol + NAD(+) <=> 11-cis-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193068", "l": "CYP17A1 17-hydroxylates PREG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55029", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine => an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45547", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29242", "l": "H(+)(in) + uracil(in) <=> H(+)(out) + uracil(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805620", "l": "KAT6A and PML bind TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31447", "l": "6-amino-2-oxohexanoate + H2O2 = 5-aminopentanoate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14875", "l": "H(+) + indole-3-acetaldehyde + NADH => indole-3-ethanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43406", "l": "H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP => N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49437", "l": "cholate + deoxycholoyl-CoA => choloyl-CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202212", "l": "Recruitment of PLC-gamma1 to LAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018798", "l": "RHOV binds GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071713", "l": "para-aminobenzoyl-glutamate hydrolase activity", "d": ["Catalysis of the reaction: para-aminobenzoyl-glutamate + H2O = para-aminobenzoate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75105", "l": "32-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209143", "l": "Phosphorylation of AXN and APC by DCO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72977", "l": "2 AMP + didemethylasterriquinone D + 2 diphosphate + H(+) => 2 ATP + 2 indole-3-pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50550", "l": "H2O + prostaglandin A1 => prostaglandin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33072", "l": "D-glucose 6-phosphate => 2-deoxy-L-scyllo-inosose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791155", "l": "Expression of EDEM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047316", "l": "glutamine-phenylpyruvate transaminase activity", "d": ["Catalysis of the reaction: keto-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30346", "l": "FAD + H(+) + succinate <=> FADH2 + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58313", "l": "25-substituted-cholesteryl beta-D-glucoside + H2O => 25-substituted-cholesterol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19266", "l": "carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36625", "l": "(3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine => 3-phenylpyruvate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37889", "l": "H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide => S-adenosyl-L-methionine + small RNA 3'-end nucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57787", "l": "1,4-dinitrobenzene + NADH + O2 <=> 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71762", "l": "2-oxoglutarate(out) + heptanedioate(in) <=> 2-oxoglutarate(in) + heptanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25395", "l": "(9Z,12Z)-octadecadienoate + O2 = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate", "d": []}, {"i": "EC:1.13.11.60", "l": "\"linoleate 8R-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50273", "l": "(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => resolvin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437234", "l": "Heat-Stable Antigen binds L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68579", "l": "ATP + H2O + xanthine(out) <=> ADP + H(+) + phosphate + xanthine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28889", "l": "H(+)(out) + L-serine(out) => H(+)(in) + L-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791016", "l": "SFTPB binds itself (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1605797", "l": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59755", "l": "L-lysyl-[protein] + tetradecanoyl-CoA <=> CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871266", "l": "YAP1 binds TEAD3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71715", "l": "H(+)(out) + L-leucyl-L-leucine(out) = H(+)(in) + L-leucyl-L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.81", "l": "\"(-)-cyclopenine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004905", "l": "type I interferon receptor activity", "d": ["Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30927", "l": "2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O = 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose", "d": []}, {"i": "EC:3.2.1.172", "l": "\"unsaturated rhamnogalacturonyl hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8866851", "l": "CFTR transits to the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42372", "l": "16-methoxytabersonine + H2O = (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31298", "l": "(2E)-2-hydroxypenta-2,4-dienoate <=> 2-oxopent-4-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64140", "l": "an N-(fatty acyl)-L-asparagine + H2O = a fatty acid + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186741", "l": "SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68522", "l": "beta-acoradiene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607721", "l": "Activation of NIK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11180", "l": "ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)", "d": []}, {"i": "EC:6.1.1.22", "l": "\"asparagine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50567", "l": "acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40823", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.004905482618113", "identifiers": [{"i": "GO:0048018", "l": "receptor ligand activity", "d": ["The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483174", "l": "PE is methylated to PC by PEMT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003961", "l": "O-acetylhomoserine aminocarboxypropyltransferase activity", "d": ["Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.21", "l": "\"beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799246", "l": "CHEK1 phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19264", "l": "ATP + H2O + heme b(in) <=> ADP + H(+) + heme b(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433711", "l": "Cis-homodimerization of nectins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56557", "l": "(2E,6E)-farnesyl diphosphate => delta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158849", "l": "Phenol can form a sulfate conjugate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203716", "l": "eNOS:Caveolin-1 complex binds to Nostrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27980", "l": "alpha-D-mannose 1-phosphate + GMP + 2 H(+) => GDP-alpha-D-mannose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72706", "l": "UDP-alpha-D-galactose(in) + UMP(out) <=> UDP-alpha-D-galactose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14440", "l": "H2O + L-lysine + O2 <=> 6-amino-2-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52851", "l": "5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine <=> 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203979", "l": "Coat Assembly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75633", "l": "plasmodiophorol C => H2O + plasmodiophorol B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30765", "l": "3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+) => H2O + L-valine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2248891", "l": "Active ARSA translocates to the lysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57179", "l": "L-arginyl-[protein] + methylglyoxal <=> N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24634", "l": "5 H(+) + 3 NADPH + nitrite => 2 H2O + 3 NADP(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205244", "l": "Recruitment of CBL to KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623643", "l": "RDH13 reduces atRAL to atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0015552", "l": "propionate transmembrane transporter activity", "d": ["Enables the transfer of propionate from one side of a membrane to the other. Propionate (or propanoate) is the organic acid CH3-CH2-COOH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75930", "l": "cyclohexylamine + H2O + NAD(+) <=> cyclohexanone + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381109", "l": "IRE1 binds IRE1 forming dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.199", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.13", "l": "\"sterol esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983156", "l": "Polyubiquitination of substrate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227783", "l": "Phosphorylation of IKKs complex mediated by MEKK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72235", "l": "2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out) = 2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21639", "l": "(E)-4-coumarate + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10673", "l": "cyclobutadithymidine in DNA => a thymidine dimer in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39872", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59633", "l": "D-xylobiose + O2 => D-xylobiono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60208", "l": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate", "d": []}, {"i": "EC:1.14.11.67", "l": "\"[histone H3]-trimethyl-L-lysine(4) demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71016", "l": "H2O + N-methylputrescine + O2 => 4-methylaminobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43527", "l": "L-allo-threonine + NADP(+) <=> aminoacetone + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67909", "l": "a primary linear alkyl sulfate ester + H2O => a primary alcohol + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201669", "l": "Beta-catenin translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52270", "l": "(1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine => 3-(aminomethyl)indole + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21516", "l": "isopiperitenone = piperitenone", "d": []}, {"i": "EC:5.3.3.11", "l": "\"isopiperitenone Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693009", "l": "Expression of AMH in testis differentiation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49589", "l": "L-erythrulose 1-phosphate => D-erythrulose 4-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33718", "l": "4-hydroxyeicosasphinganine 1-phosphate <=> 2-hydroxyoctadecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099521", "l": "ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential", "d": ["Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48503", "l": "H2O + octanoylglycerol <=> glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465941", "l": "A REH hydrolyses 11cRE to 11cROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15479", "l": "5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 5beta-scymnol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38561", "l": "(R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102850", "l": "1-18:1-2-16:0-phosphatidylglycerol omega-6 desaturase activity", "d": ["Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.88", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22070", "l": "(2S)-2-acetolactate + H(+) + NADPH => (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24490", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13220", "l": "H2O + NAD(+) + succinate semialdehyde <=> 2 H(+) + NADH + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21971", "l": "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate <=> 3-dehydroquinate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102590", "l": "delphinidin 3-O-rutinoside 7-O-glucosyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: delphinidin 3-O-rutinoside + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> delphinidin 3-O-rutinoside-7-O-glucoside + 4-hydroxybenzoic acid + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52478", "l": "estrone 3-O-(beta-D-glucuronate) + H(+) + UDP => estrone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37003", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192325", "l": "25(R) THCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22746", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63932", "l": "abscisate(in) + ATP + H2O = abscisate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25585", "l": "alpha-L-rhamnose => beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814674", "l": "Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4411383", "l": "NLK phosphorylates TCF/LEF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13361", "l": "CTP + H(+) + sn-glycerol 3-phosphate = CDP-glycerol + diphosphate", "d": []}, {"i": "EC:2.7.7.39", "l": "\"glycerol-3-phosphate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10215", "l": "2-oxoglutarate + 5-aminopentanoate <=> 5-oxopentanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014343", "l": "IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16831", "l": "a carboxylate + H(+) + H2O2 => an aldehyde + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11851", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine <=> [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70231", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+) = (S)-2-benzoylsuccinyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.429", "l": "\"(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396370", "l": "VTN binds collagens II, III and V (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669302", "l": "p-BMAL1:p-CLOCK,NPAS2 binds RORA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033781", "l": "cholesterol 24-hydroxylase activity", "d": ["Catalysis of the reaction: cholesterol + H+ + NADPH + O2 = (24S)-24-hydroxycholesterol + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374677", "l": "L1 binds ERM family members (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24207", "l": "acetyl phosphate + H(+) + sulfite <=> phosphate + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18229", "l": "glycolate + NAD(+) = glyoxylate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.26", "l": "\"glyoxylate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52115", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA <=> 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854303", "l": "TBC1D11 binds RAB6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63609", "l": "apelin-17 + H2O => apelin-16 + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190687", "l": "Connexin oligomerization in  ER-Golgi-Intermediate Compartment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14539", "l": "1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+) => 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247847", "l": "WLS is endocytosed to the early endosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0043752", "l": "adenosylcobinamide kinase activity", "d": ["Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635102", "l": "GPR161 is internalized (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705926", "l": "AR binds AR agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24104", "l": "7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine", "d": []}, {"i": "EC:2.4.2.29", "l": "\"tRNA-guanosine(34) preQ1 transglycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28346", "l": "7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate", "d": []}, {"i": "EC:5.1.99.7", "l": "\"dihydroneopterin triphosphate 2'-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64426", "l": "H(+)(in) + L-leucyl-L-proline(in) => H(+)(out) + L-leucyl-L-proline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798528", "l": "S100A8:S100A9 binds Mn2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31426", "l": "(2Z,6E)-farnesyl diphosphate <=> (-)-alpha-cedrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623059", "l": "FOXO1 binds POMC gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047939", "l": "L-glucuronate reductase activity", "d": ["Catalysis of the reaction: L-gulonate + NADP+ = D-glucuronate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65860", "l": "A + Delta(1)-dihydrotestosterone + H2O = 17beta-hydroxyandrostan-1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9612501", "l": "SGK phosphorylates CREB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465940", "l": "atRAL is reduced to atROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47450", "l": "(2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57581", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => S-methyl-1-thiol-D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41931", "l": "(2E)-octadecenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + octadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75148", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (-)-cyatha-3,12-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167429", "l": "The receptor:G-protein complex  binds GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976551", "l": "NOTCH2 stimulates GZMB transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22732", "l": "4-hydroxyphenylacetate + H(+) = 4-methylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140813", "l": "urate:monoatomic anion antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urate(out) + anion (in) = urate (in) + anion (out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30263", "l": "H2O2 + 2 L-ascorbate = 2 H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102786", "l": "stearoyl-[acp] desaturase activity", "d": ["Catalysis of the reaction: O2 + a stearoyl-[acp] + a reduced ferredoxin = 2 H2O + an oleoyl-[acp] + an oxidized ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417908", "l": "P2RY1 binds ADP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55435", "l": "11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003910", "l": "DNA ligase (ATP) activity", "d": ["Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51109", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36132", "l": "(indol-3-yl)acetate + S-adenosyl-L-methionine => methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606564", "l": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340214", "l": "CYGB binds O2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74067", "l": "ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42319", "l": "a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004157", "l": "dihydropyrimidinase activity", "d": ["Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32323", "l": "ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.86", "l": "\"ent-kaurene monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222325", "l": "Carboxymycobactin and mycobactin exchange their iron load (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67159", "l": "1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72231", "l": "chloride(out) + N-methyl-L-proline(out) + 2 Na(+)(out) = chloride(in) + N-methyl-L-proline(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37107", "l": "H2O + N(7)-methyl-GMP = N(7)-methylguanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112434", "l": "Formation of DSIF complex  (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29373", "l": "2'-deoxyadenosine + phosphate => dAMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29431", "l": "ATP + phosphate = ADP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2471842", "l": "Collagen type XXV ectomain shedding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15870", "l": "2-oxoglutarate + D-alanine => D-glutamate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16940", "l": "1-O-alkyl-sn-glycerol + ATP <=> 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72257", "l": "3-methoxytyramine + H(+) + S-adenosyl-L-homocysteine => dopamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987120", "l": "JAK1 binds IFNLR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16148", "l": "CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61917", "l": "ATP + fluconazole(in) + H2O => ADP + fluconazole(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69382", "l": "4-methyl-2-oxopentanoate + H2O2 => 2-hydroxy-4-methylpentanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64781", "l": "S-benzyl-L-cysteine => 2-aminoprop-2-enoate + benzylthiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67905", "l": "glutaryl-CoA + H(+) + malonyl-[ACP] => 3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982637", "l": "Opsins binds G alpha-t (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844618", "l": "dsDNA:AIM2:ASC cluster binds procaspase-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0004032", "l": "alditol:NADP+ 1-oxidoreductase activity", "d": ["Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13121", "l": "ATP + shikimate = 3-phosphoshikimate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.71", "l": "\"shikimate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67337", "l": "kaempferol 3-O-beta-D-glucoside + malonyl-CoA => CoA + kaempferol 3-O-(6-O-malonyl-beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682826", "l": "LGI1 binds ADAM11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0071771", "l": "aldehyde decarbonylase activity", "d": ["Catalysis of the reaction: a C(n) aldehyde = C(n-1) alkane + CO."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603062", "l": "Complexed PIWIL2 binds  pre-piRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008692", "l": "IL37(?-218) binds SMAD3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31341", "l": "acetyl-[ACP] + AMP + diphosphate => acetate + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36041", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000122", "l": "CD320 binds extracellular TCN2:RCbl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800315", "l": "MST1 binds MST1R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-398185", "l": "LARG binds plexin B1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004909", "l": "interleukin-1, type I, activating receptor activity", "d": ["Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112395", "l": "Abortive termination of elongation after arrest (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55163", "l": "coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21826", "l": "L-glutamate + oxaloacetate => 2-oxoglutarate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164616", "l": "Biogenesis and assembly of the telomerase RNP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0031491", "l": "nucleosome binding", "d": ["Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047099", "l": "CDP-4-dehydro-6-deoxyglucose reductase activity", "d": ["Catalysis of the reaction: H2O + NAD(P)+ + CDP-4-dehydro-3,6-dideoxy-D-glucose = NAD(P)H + CDP-4-dehydro-6-deoxy-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66981", "l": "2-methylbutanoyl-CoA + H2O => 2-methylbutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66485", "l": "16alpha-hydroxygypsogenate + UDP-alpha-D-glucose => 16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20673", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710959", "l": "p-STAT1 dimer binds KPNA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33823", "l": "3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH = NAD(+) + tetrahydro-4-hydroxyphenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30079", "l": "ATP + CoA + crotonobetaine = AMP + crotonobetainyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2317332", "l": "PIP3 recruits AKT to the membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49299", "l": "keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + L-sorbose 1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21097", "l": "3-dehydroquinate => 3-dehydroshikimate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638156", "l": "RBFOX3 (NeuN) gene expression is stimulated by NPAS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74418", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44403", "l": "3-demethylubiquinol-6 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70599", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404135", "l": "RBP4 binds atROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726621", "l": "PGR binds PGR antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-398185", "l": "LARG binds plexin B1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5140741", "l": "WNT5A binds FZD and ROR receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38889", "l": "hexanoate + sphinganine => H2O + N-hexanoyl-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177920", "l": "Binding of GRB2 to GAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730858", "l": "Autophosphorylation of BTK/ITK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40826", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29362", "l": "H2O + UMP <=> phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52470", "l": "16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17beta-estriol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70838", "l": "L-arginine(in) + L-glutamine(out) + Na(+)(out) <=> L-arginine(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53113", "l": "3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) => 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45428", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine = H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35429", "l": "(E)-sinapate + cyanidin 3,5-di-O-beta-D-glucoside => 1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420883", "l": "Opsins act as GEFs for G alpha-t (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27314", "l": "dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 = 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)", "d": []}, {"i": "EC:1.13.12.17", "l": "\"dichloroarcyriaflavin A synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109862", "l": "MAP2K2 phosphorylates MAPK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981926", "l": "RAC1 and CDC42 activate PAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023173", "l": "Insulin secretory granule docks at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848077", "l": "PTK6 phosphorylates STAP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016596", "l": "thienylcyclohexylpiperidine binding", "d": ["Binding to thienylcyclohexylpiperidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10373", "l": "CoA + NAD(+) + phenylglyoxylate => benzoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51876", "l": "2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate = desmethylxanthohumol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204773", "l": "Interaction of Tie2 and Grb7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15008", "l": "2-oxoglutarate + gibberellin A1 + O2 <=> CO2 + gibberellin A8 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57001", "l": "acetyl-CoA + streptothricin F => CoA + H(+) + N(beta)-acetylstreptothricin F", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12269", "l": "2-oxoglutarate + putrescine => 1-pyrroline + H2O + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64552", "l": "(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase] = 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676257", "l": "Formation of the SET1A complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-500708", "l": "GRIK3 homomer binds glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60775", "l": "2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2 <=> 3 CO2 + gibberellin A9 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48368", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432537", "l": "PP2A dephosphorylates phosphorylated CLK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13835", "l": "5-guanidino-2-oxopentanoate + L-alanine => L-arginine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74171", "l": "an N-methyl carbamate ester + H(+) + H2O = an alcohol + CO2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64584", "l": "2-hydroxyethane-1-sulfonate(out) + Na(+)(out) = 2-hydroxyethane-1-sulfonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167408", "l": "The high affinity receptor complex binds to G-protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798374", "l": "DYRK2 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013110", "l": "RHOC binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404144", "l": "Parenchymal atROL translocates to HSCs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45352", "l": "9,10-epoxyoctadecanoate + H2O = 9,10-dihydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-377640", "l": "Autophosphorylation of SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15892", "l": "H2O + L-glutamine <=> L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16899", "l": "a 3beta-hydroxysteroid ester + a diacylglycerol => a 3beta-hydroxysteroid + a triacylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944266", "l": "Association of procollagen type XI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30935", "l": "H2O + nicotinate beta-D-ribonucleotide = beta-D-ribosylnicotinate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51835", "l": "ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54699", "l": "4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase] <=> 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40760", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870710", "l": "APP gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65156", "l": "2-oxoglutarate + O2 + preaustinoid A2 = CO2 + H2O + preaustinoid A3 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-708349", "l": "Activated NOD2 oligomerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748991", "l": "XDH oxidises 6MP to 6TU (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296326", "l": "HCAR1 binds LACT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174157", "l": "Degradation of multiubiquitinated Cyclin B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139899", "l": "Sequestration of BAD protein by 14-3-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45682", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out) => N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18112", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948136", "l": "ULK1 Translocates to the mitochondria (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60040", "l": "H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate = (2E)-3-methylhex-2-enoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102638", "l": "[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase activity", "d": ["Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl diphosphate = [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847534", "l": "RAB43 hydrolyses GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70737", "l": "chloride(in) + glycine betaine(in) + 2 Na(+)(in) => chloride(out) + glycine betaine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35308", "l": "H(+) + NADH + O2 + salicylate => 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51896", "l": "H2O + N(1)-acetylspermine = acetate + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65512", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2 = 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33785", "l": "1,6-kestotetraose + beta-D-glucose => 1(F)-beta-D-fructosylsucrose + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37240", "l": "2',3'-cyclophospho-UMP + H2O => H(+) + uridine 2'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45874", "l": "4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA => 15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36514", "l": "(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA <=> (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50487", "l": "acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24779", "l": "H2O + pheophorbide a <=> C-13(2)-carboxypyropheophorbide a + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759950", "l": "miR-200c-3p binds CDH11 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37035", "l": "H2O + L-2-aminopentanoate + NAD(+) = 2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8856808", "l": "Recruitment of AP-2 complex and clathrin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70438", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + O2 <=> a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379848", "l": "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36509", "l": "3-oxotetracosanoyl-CoA + CO2 + CoA => docosanoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50087", "l": "ATP + H2O + taurolithocholate 3-sulfate(in) <=> ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27513", "l": "7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine <=> dehydro coenzyme F420-0 + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45493", "l": "phycocyanobilin-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183051", "l": "CBL ubiquitinates Sprouty (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182990", "l": "Sprouty sequesters CBL away from active EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.116", "l": "\"D-arabinose 1-dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953452", "l": "E2F6.com-1 complex binds the E2F1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18636", "l": "2 ATP + H2O + hydrogencarbonate + L-glutamine <=> 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35477", "l": "(S)-5'-oxoaverantin + H(+) + NADH => (1'S,5'S)-5'-hydroxyaverantin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47625", "l": "cis-3-hydroxy-L-proline => 1-pyrroline-2-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64237", "l": "atrochrysone carboxyl-[ACP] + H2O => atrochrysone carboxylate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102472", "l": "eriodictyol 2-hydroxylase activity", "d": ["Catalysis of the reaction: eriodictyol + NADPH + O2 + 2 H+ <=> 2-hydroxyeriodictyol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18862", "l": "a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine => a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938853", "l": "CDK6 binds RUNX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849900", "l": "SALMs1-3 bind each other in cis interactions (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195275", "l": "Phosphorylation of APC component of the destruction complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17170", "l": "acetyl-CoA + alpha-D-galactosamine 1-phosphate => CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43782", "l": "(2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50584", "l": "13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66490", "l": "quillaic acid 28-beta-D-glucoside + UDP => quillate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38350", "l": "(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate <=> 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28876", "l": "H(+)(in) + L-tyrosine(in) => H(+)(out) + L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018766", "l": "RHOU binds effectors at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196417", "l": "Reduction of desmosterol to cholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211651", "l": "Cleavage of PAK-2 at 212 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48019", "l": "4-methyl-5-nitrocatechol + NADH + O2 <=> 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686578", "l": "Activated ATM phosphorylates ABL1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52252", "l": "a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26026", "l": "8'-apo-beta-carotenol + O2 <=> (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49402", "l": "phosphate + validoxylamine A => H2O + validoxylamine A 7'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44692", "l": "a fatty acyl-CoA + hexadecasphinganine = CoA + H(+) + N-acylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16964", "l": "epsilon-(gamma-L-glutamyl)-L-lysine <=> 5-oxo-L-proline + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.19", "l": "\"lycopene beta-cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55661", "l": "2 AH2 + all-trans-beta-carotene + 2 O2 => 2 A + echinenone + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45670", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009309", "l": "RUNX2 binds STUB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211960", "l": "CYP2U1 19-hydroxylates ARA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42367", "l": "2 a 2-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392195", "l": "Gi activation by P2Y purinoceptor 12 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9022314", "l": "HIPK2 phosphorylates MECP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56312", "l": "3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205649", "l": "p62 links damaged mitochondria to LC3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614460", "l": "Dimerization of procollagen type VI (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47384", "l": "4-acetoxyphenol + H2O = acetate + H(+) + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51971", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 <=> (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199131", "l": "PVR binds CD226 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41599", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH <=> (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2562541", "l": "TLR4-induced ripoptosome assembly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58036", "l": "8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = 8-epi-inunolide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983424", "l": "Budding of COPII coated vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74514", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B <=> aspoquinolone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61153", "l": "(E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0004954", "l": "prostanoid receptor activity", "d": ["Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44846", "l": "CoA + O-eicosanoyl-(R)-carnitine => (R)-carnitine + eicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647977", "l": "ICMT methylates S-Farn RAS proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47629", "l": "glyoxylate + H2O + propanoyl-CoA => 3-methylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22411", "l": "dimethylallyl diphosphate + isopentenyl diphosphate <=> (2E)-geranyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9754129", "l": "CDK6 inhibitors bind CDK6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75797", "l": "Na(+)(in) + nicotinate(in) => Na(+)(out) + nicotinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17610", "l": "L-seryl-[sulfatase] + S-adenosyl-L-methionine => 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008872", "l": "glucarate dehydratase activity", "d": ["Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16999", "l": "3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13634", "l": "ATP + L-glutamate + putrescine => ADP + gamma-L-glutamylputrescine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36079", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine = a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55399", "l": "(R)-carnitine + H(+) + NADH + O2 <=> (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18969", "l": "a long-chain fatty acid + H(+) + hnu = a long-chain alkane + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12292", "l": "ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74463", "l": "(-)-4'-methoxycyclopenine = 4'-methoxyviridicatin + H(+) + methyl isocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56021", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33877", "l": "(9Z)-octadecenoate + cholesterol + H(+) => cholesteryl (9Z-octadecenoate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13106", "l": "glycerol 2-phosphate + H2O => glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58478", "l": "a 1-acyl-sn-glycero-3-phosphocholine + CoA => an acyl-CoA + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685604", "l": "SLAMF6 binds SLAMF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74486", "l": "(Z)-dehydrocyclopeptine + 2-oxoglutarate + O2 <=> (-)-cyclopenine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61681", "l": "ATP + holo-[peptidyl-carrier protein] + L-cysteine => AMP + diphosphate + L-cysteinyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29891", "l": "ATP + H2O + L-histidine(out) = ADP + H(+) + L-histidine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63519", "l": "biphenyl-2,2',3-triol + H(+) + NADH + O2 <=> biphenyl-2,2',3,3'-tetraol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050781", "l": "ortho-trichlorophenol reductive dehalogenase activity", "d": ["Catalysis of the reaction: 2,4,6-trichlorophenol + 2 H+ + 2 e- = 2,4-dichlorophenol + HCl."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54964", "l": "hexadecanoyl-[ACP] + phosphate = hexadecanoyl phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707690", "l": "BACH1 binds MAFK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102515", "l": "pelargonidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose <=> pelargonidin 3,7-di-O-beta-D-glucoside + ferulate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64429", "l": "glycyl-L-proline(out) + H(+)(out) => glycyl-L-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419003", "l": "Interaction of Nectins with Afadin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700171", "l": "Active ALK phosphorylates PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56763", "l": "24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821368", "l": "AKAP8L binds MLL1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2152276", "l": "Secretion of transmembrane collagens (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52705", "l": "H2O + UMP => D-ribose 5-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646295", "l": "p14ARF mutant does not translocate to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38280", "l": "(3R)-citramalate + succinyl-CoA => (3R)-citramalyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55432", "l": "11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.61", "l": "\"carnosic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001223", "l": "transcription coactivator binding", "d": ["Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29390", "l": "CTP + H2O <=> CDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015433", "l": "ABC-type peptide antigen transporter activity", "d": ["Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58467", "l": "a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine <=> a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-392749", "l": "Transport of L1 into endosomes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18120", "l": "L-tyrosine + O2 <=> H2O + L-dopaquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18411", "l": "4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12290", "l": "an alcohol + L-fucose => an alpha-L-fucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72334", "l": "3-hydroxy-4-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) <=> 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72761", "l": "anthocyanin A8 + CoA => anthocyanin A6 + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74885", "l": "GUCYs converts GTP to cGMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608825", "l": "DVL2 is phosphorylated after WNT5A binding to FZD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38058", "l": "CTP + phytol <=> CDP + H(+) + phytyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114352", "l": "Sequestration of tBID by BCL-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189439", "l": "ALAD condenses 2 dALAs to form PBG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35680", "l": "dodecanoyl-CoA + H(+) + L-serine => 3-oxotetradecasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-434650", "l": "MATEs mediate extrusion of xenobiotics (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67459", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62841", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001052", "l": "plastid PEP RNA polymerase core enzyme binding", "d": ["Binding to a bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56440", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690669", "l": "CD22 binds itself to form homo-oligomers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33299", "l": "[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine", "d": []}, {"i": "EC:2.5.1.46", "l": "\"deoxyhypusine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018475", "l": "trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity", "d": ["Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + trans-2-methyl-5-isopropylhexa-2,5-dienoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21105", "l": "AH2 + cholesterol + O2 => 25-hydroxycholesterol + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21641", "l": "NADP(+) + prephenate => 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102166", "l": "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity", "d": ["Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-L-threonine-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [protein]-L-threonine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29007", "l": "H(+)(in) + Mn(2+)(in) = H(+)(out) + Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75863", "l": "all-trans-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxy-13,14-dihydroretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209309", "l": "Phosphorylated REL-68 transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30363", "l": "fumonisin B1 + 2 H2O = (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate", "d": []}, {"i": "EC:3.1.1.87", "l": "\"fumonisin B1 esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40585", "l": "CoA + H(+) + hexanedioate => H2O + hexanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25324", "l": "N-methylethanolamine phosphate + S-adenosyl-L-methionine <=> H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008787", "l": "allose kinase activity", "d": ["Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624131", "l": "UNC119B binds myristoylated proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50818", "l": "5alpha-androstan-3,17-dione + NADP(+) => androst-4-ene-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071886", "l": "1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding", "d": ["Binding to the amine 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine, a serotonin receptor agonist that can act as a psychedelic drug."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72667", "l": "O2 + reduced [NADPH--hemoprotein reductase] + secologanin = 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + secoxyloganin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.81", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22775", "l": "L-fuconate <=> 2-dehydro-3-deoxy-L-fuconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848864", "l": "PTK6 binds ARAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362549", "l": "Hh-Np traffics to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72507", "l": "2-oxoglutarate(in) + prostaglandin F2alpha(out) = 2-oxoglutarate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168400", "l": "iE-DAP elicits a NOD1 response (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67667", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O <=> 1,2-diacyl-sn-glycero-3-phosphoethanolamine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61361", "l": "ATP + H2O + pheophorbide a(in) => ADP + H(+) + pheophorbide a(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12913", "l": "(R)-lipoate + ATP + H(+) = (R)-lipoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66575", "l": "2-naphthol + 3'-phosphoadenylyl sulfate <=> 2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102127", "l": "8-oxoguanine deaminase activity", "d": ["Catalysis of the reaction: H+ + 7,8-dihydro-8-oxoguanine + H2O <=> 7,9-dihydro-1H-purine-2,6,8(3H)-trione + ammonium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3240957", "l": "Formation of PRC2-EZH2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51230", "l": "17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => 17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507871", "l": "Aquaporins passively transport glycerol out of cells (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61409", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysine => ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.93", "l": "\"proprotein convertase 1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932033", "l": "KCTD6 gene expression is stimulated by RUNX1 and ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43955", "l": "3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 <=> H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5444516", "l": "Formation of MSH2:MSH6 Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35660", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose => GDP + H(+) + mannosylinositol phosphorylphytoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39836", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41127", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9670673", "l": "FIX is secreted (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46303", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42223", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate <=> 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627106", "l": "SMAC (DIABLO) forms dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33251", "l": "2 sucrose = 6-kestotriose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9828175", "l": "Formation of the NSL complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18569", "l": "an aromatic aldehyde + H2O + O2 = an aromatic carboxylate + H(+) + H2O2", "d": []}, {"i": "EC:1.2.3.9", "l": "\"aryl-aldehyde oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28167", "l": "5-nitroanthranilate + H(+) + H2O => 5-nitrosalicylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42579", "l": "2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O <=> 2-methylpropanoate + 2-oxopent-4-enoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22464", "l": "L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381087", "l": "Dimerization of PERK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74919", "l": "a (2E)-2-fatty-enoyl-AMP + holo-[ACP] = a (2E)-enoyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71527", "l": "thymine(out) = thymine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196773", "l": "COASY phosphorylates DP-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17400", "l": "a (3R)-hydroxyacyl-[ACP] + NADP(+) <=> a 3-oxoacyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65826", "l": "dec-9-ynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => dec-9-enoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59791", "l": "H2O + NAD(+) + pseudopaline <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64110", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine => H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39453", "l": "(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47607", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) <=> CMP + ganglioside GP1calpha (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48727", "l": "aurachin B + H(+) + H2O <=> 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190260", "l": "FGFR2b binds to FGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090556", "l": "phosphatidylserine floppase activity", "d": ["Catalysis of the movement of phosphatidylserine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}, {"i": "RHEA:38567", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177937", "l": "Phosphorylation of EGFR by SRC kinase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73824", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62584", "l": "ATP + H2O + L-tyrosine(out) = ADP + H(+) + L-tyrosine(in) + phosphate", "d": []}, {"i": "EC:7.4.2.13", "l": "\"ABC-type tyrosine transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18425", "l": "L-quinate + NADP(+) = 3-dehydroquinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671737", "l": "p-T774-PKN1 binds CDC25C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31027", "l": "2-trans-(+)-abscisate + UDP-alpha-D-glucose = beta-D-glucopyranosyl trans-(+)-abscisate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13131", "l": "4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP => cis-4-coumarate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664850", "l": "ATM binds PEX5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40659", "l": "1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65052", "l": "4-(trifluoromethyl)benzyl alcohol + NAD(+) = 4-(trifluoromethyl)benzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418856", "l": "Activation of Rac1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017174", "l": "glycine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10063", "l": "acetyl-CoA + D-tryptophan <=> CoA + H(+) + N-acetyl-D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36371", "l": "(2S)-hydroxybutanoate + NAD(+) = 2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52062", "l": "(9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+) => 12-(9Z-octadecenoyloxy)-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22135", "l": "ATP + D-maltose(out) + H2O <=> ADP + D-maltose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008457", "l": "beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20919", "l": "L-cysteine + sulfite <=> hydrogen sulfide + L-cysteate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68578", "l": "ADP + H(+) + phosphate + xanthine(in) => ATP + H2O + xanthine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57077", "l": "3-oxoisoapionate 4-phosphate + H2O => (2R)-3-phosphoglycerate + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71750", "l": "2-oxoglutarate(out) + L-2-aminoadipate(in) <=> 2-oxoglutarate(in) + L-2-aminoadipate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.104", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68044", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20606", "l": "cytosine + H(+) + H2O => NH4(+) + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666001", "l": "Profilin:G-actin binds MKL1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429415", "l": "SYK binds to integrin alphaIIb beta3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17740", "l": "NADP(+) + shikimate <=> 3-dehydroshikimate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35957", "l": "6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033191", "l": "macrophomate synthase activity", "d": ["Catalysis of the reaction: a 2-pyrone + oxalacetate = macrophomate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177284", "l": "PKA phosphorylates PDE4B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196753", "l": "2xPPCS ligates PPanK with Cys (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419645", "l": "Dimerization of LIMK1 by Hsp90 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43151", "l": "adenosine(9) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40005", "l": "(Z)-biformene + diphosphate => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61952", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295632", "l": "PPA2A dephosphorylates SPRY2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928639", "l": "p-EFNB binds GRB4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35374", "l": "2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) <=> (beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051401", "l": "CH domain binding", "d": ["Binding to a calponin homology protein domain, a domain of 100 residues that occurs in signaling and cytoskeletal proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13995", "l": "2-methyl-3-oxopropanoate + L-glutamate => (S)-3-amino-2-methylpropanoate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65593", "l": "8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] => 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70596", "l": "GOT2 dimer deaminates L-Asp (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201608", "l": "Caspase-mediated cleavage of alpha adducin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70860", "l": "L-asparagine(in) + L-glutamine(out) + Na(+)(out) => L-asparagine(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685230", "l": "CHEK1 phosphorylates RAD51 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38871", "l": "uridine(2457) in 23S rRNA = pseudouridine(2457) in 23S rRNA", "d": []}, {"i": "EC:5.4.99.20", "l": "\"23S rRNA pseudouridine(2457) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28369", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate <=> beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44114", "l": "CoA + nonyl hexadecanoate => hexadecanoyl-CoA + nonan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446391", "l": "Formation of the PINCH-ILK-parvin complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64326", "l": "cholesteryl (11Z)-octadecenoate + CoA => (11Z)-octadecenoyl-CoA + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693722", "l": "Unknown sepiapterin synthase transforms PTHP to sepiapterin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627104", "l": "XIAP binds CASP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12628", "l": "(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose <=> D-glucose + sinapoyl (S)-malate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20877", "l": "(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32009", "l": "diphosphate + isopimara-8(14),15-diene => 9alpha-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62437", "l": "L-lyxonate => 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106325", "l": "acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69775", "l": "(2E,6E)-farnesyl diphosphate = beta-ylangene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8863727", "l": "STON2 is neddylated (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51906", "l": "10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate => 10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46118", "l": "D-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-D-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8873946", "l": "OTUD3 deubiquitinates PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10543", "l": "7,8-dihydroneopterin <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31073", "l": "(S)-3-amino-2-methylpropanoate + pyruvate => (S)-methylmalonate semialdehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.85", "l": "\"6-phospho-beta-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692315", "l": "OX40L binds OX40 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033488", "l": "Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41387", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750942", "l": "USP14 deubiquitinates NLRC5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183067", "l": "Localization of CBL:GRB2 to the membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647980", "l": "mature RAS proteins translocate to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693250", "l": "RHOD binds effectors at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49994", "l": "H2O + NAD(+) + propan-2-ol => H(+) + NADH + O2 + propane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75529", "l": "benzaldehyde + FMN + H(+) + H2O + N-acetyl-S-hydroxy-L-cysteine => (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30142", "l": "H2O + octadecanoyl-CoA <=> CoA + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13891", "l": "AMP + FMN + 2 H(+) => FAD + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-435244", "l": "PECAM1 is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008826", "l": "cysteine sulfinate desulfinase activity", "d": ["Catalysis of the reaction: 3-sulfinoalanine = L-alanine + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849908", "l": "SALM4 binds flotillin-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.452777855834967", "identifiers": [{"i": "GO:0043177", "l": "organic acid binding", "d": ["Binding to an organic acid, any acidic compound containing carbon in covalent linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61899", "l": "betaenone C <=> betaenone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13304", "l": "a 1,2-diacyl-sn-glycerol + a sterol <=> a 1-acyl-sn-glycerol + a sterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46231", "l": "apo-[peptidyl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.3", "l": "\"nitrate reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47066", "l": "4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40497", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28273", "l": "acetyl-CoA + spermidine <=> CoA + H(+) + N(8)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193684", "l": "p62 recruits an atypical PKC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029680", "l": "Caspase-7 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29692", "l": "alpha-maltotetraose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.-", "l": "\"Phosphotransferases with an alcohol group as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23673", "l": "a quinone + L-quinate => 3-dehydroquinate + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67726", "l": "CMP(in) + CMP-N-acetyl-beta-neuraminate(out) => CMP(out) + CMP-N-acetyl-beta-neuraminate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35353", "l": "(2E)-octadecenoyl-CoA + H(+) + NADPH => NADP(+) + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130731", "l": "Formation of COPII vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36944", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682388", "l": "Autophagosome maturation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67882", "l": "adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + H(+) => 3'-phosphoadenylyl sulfate + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21076", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 = CO2 + succinate + uridine", "d": []}, {"i": "EC:1.14.11.3", "l": "\"pyrimidine-deoxynucleoside 2'-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41524", "l": "5 H(+) + 5 malonyl-CoA = 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol", "d": []}, {"i": "EC:2.3.1.233", "l": "\"1,3,6,8-tetrahydroxynaphthalene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109700", "l": "AKT2 binds PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033042", "l": "umami taste receptor activity", "d": ["Combining with soluble umami compounds to initiate a change in cell activity. These receptors are responsible for the sense of umami taste, the savory taste of meats and other foods that are rich in glutamates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57145", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41675", "l": "1-O-hexadecyl-sn-glycerol + ATP <=> 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1606288", "l": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9670673", "l": "FIX is secreted (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70627", "l": "H2O + N(6)-dodecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-dodecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26254", "l": "H(+) + isopimara-7,15-dienol + NADPH + O2 => 2 H2O + isopimara-7,15-dienal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12307", "l": "(S)-2-amino-6-oxohexanoate + H2O + NADP(+) <=> 2 H(+) + L-2-aminoadipate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68397", "l": "a percarboxylic acid + H2O => a carboxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41857", "l": "3-oxodecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxydecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735840", "l": "SARS-CoV-1 7a binds BST2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26512", "l": "L-proline + NH4(+) => H2O + L-prolinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938121", "l": "SERPINB13 binds CTSK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30887", "l": "4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin = 7,8-dihydropteroate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70748", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74060", "l": "beta-alanine(out) + L-alanine(in) => beta-alanine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38581", "l": "(20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42759", "l": "cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389523", "l": "BTLA interacts with HVEM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24529", "l": "(R)-lactaldehyde + NAD(+) => H(+) + methylglyoxal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682709", "l": "LGI4 binds ADAM22,23,11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60015", "l": "a tRNA with a 3' CC end + ATP <=> a tRNA with a 3' CCA end + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186819", "l": "SH2 domain of Src binds to the active receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64136", "l": "H2O + N-(9Z-octadecenoyl)-L-asparagine = (9Z)-octadecenoate + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016217", "l": "N-ethylammeline chlorohydrolase activity", "d": ["Catalysis of the reaction: deethylsimazine + H2O = N-ethylammeline + chloride + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20735", "l": "[protein]-dithiol + [thioredoxin]-disulfide <=> [protein]-disulfide + [thioredoxin]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047401", "l": "trithionate hydrolase activity", "d": ["Catalysis of the reaction: H2O + trithionate = H+ + sulfate + thiosulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218805", "l": "PKC autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13991", "l": "alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose => alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47238", "l": "(2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein] => eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50751", "l": "H2O + juglone <=> naphthalene-1,2,4,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72094", "l": "(R)-carnitine(out) + Na(+)(out) <=> (R)-carnitine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174124", "l": "Dephosphorylation of phospho-Cdh1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008273", "l": "calcium, potassium:sodium antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44788", "l": "2-demethylmenaquinol-11 + S-adenosyl-L-methionine = H(+) + menaquinol-11 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964619", "l": "PAK1 binds ARHGEF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218812", "l": "FYN phosphorylates PAK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388808", "l": "CD28 homodimer binds B7-2 monomer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59504", "l": "cholesterol + glycyl-L-cysteinyl-[protein] + H(+) = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56587", "l": "1,2-epoxypropane + H2O <=> propane-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63566", "l": "apelin-12 + L-phenylalanine => apelin-13 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38330", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390673", "l": "CHRM2,4 bind acetylcholine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799350", "l": "Exocytosis of specific granule membrane proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9626914", "l": "α2-agonists bind ADRA2A,B,C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50058", "l": "ADP + glycocholate(out) + H(+) + phosphate => ATP + glycocholate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34545", "l": "H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP => N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64727", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15298", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose => 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694433", "l": "MIA2 binds PREB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38724", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63404", "l": "3,6-dichloropyridine-2,5-diol + FADH2 + O2 = 6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013159", "l": "CDC42 GEFs activate CDC42 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514790", "l": "Elastin degradation by MMP14 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11884", "l": "3'-phosphoadenylyl sulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+)", "d": []}, {"i": "EC:2.8.2.18", "l": "\"cortisol sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49306", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine => a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10734", "l": "AMP + CO2 + diphosphate + firefly oxyluciferin + hnu => ATP + firefly D-luciferin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033509", "l": "USP9X binds Ub:PEX5L (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63097", "l": "ilicicolin A epoxide => ilicicolin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13333", "l": "beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 2-phosphate + phosphate", "d": []}, {"i": "EC:3.1.3.54", "l": "\"fructose-2,6-bisphosphate 6-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6794346", "l": "NRXNs bind NLGNs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49272", "l": "alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] = calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45968", "l": "androst-4-ene-3,17-dione + H(+) + NADH + O2 = 9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549533", "l": "Expression of PERIOD-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67445", "l": "an (R)-2-hydroxy-long-chain-fatty acyl-CoA => a long-chain fatty aldehyde + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784436", "l": "An unknown carrier transports mitochondrial glyoxylate to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61502", "l": "delphinidin 3-O-beta-D-glucoside + UDP => delphinidin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39172", "l": "3-oxoeicosanoyl-CoA + H(+) + NADPH => (3R)-hydroxyeicosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64021", "l": "GTP + L-seryl-[protein] => GDP + H(+) + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20018", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 => 5,10-methylenetetrahydromethanopterin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641205", "l": "RSPO:LGR binds ZNRF3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936851", "l": "AHRR binds ARNT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209760", "l": "Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30950", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-gamma-eudesmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63939", "l": "3 a ubiquinone + protoporphyrinogen IX <=> 3 a ubiquinol + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19447", "l": "anthranilate + CO2 + H(+) => 2,3-dihydroxyindole + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983138", "l": "Transport of MHC heterotrimer to ER exit site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211191", "l": "Association of DFF with alpha:beta importin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73102", "l": "3'-dephospho-CoA(in) + AMP(out) <=> 3'-dephospho-CoA(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21821", "l": "L-homocysteine + S-adenosyl-L-methionine => H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690449", "l": "S1PR1 bind S1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65126", "l": "benzyl acetate + CoA => benzoyl-CoA + ethanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0099101", "l": "G-protein gated potassium channel activity", "d": ["A potassium channel activity that is gated by binding of a G-protein beta-gamma dimer."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429699", "l": "CERT1-2 binds ceramide (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41304", "l": "H2O + N-dodecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + dodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2464822", "l": "RDH12 reduces atRAL to atROL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018629", "l": "2-hydroxyquinoline 5,6-dioxygenase activity", "d": ["Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010295", "l": "(+)-abscisic acid 8'-hydroxylase activity", "d": ["Catalysis of the reaction: (+)-abscisate + H+ + NADPH + O2 = (+)-8'-hydroxyabscisate + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61114", "l": "(2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52778", "l": "camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase] => 2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70349", "l": "3-bromo-L-tyrosine + NADPH => bromide + L-tyrosine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102161", "l": "copal-8-ol diphosphate synthase activity", "d": ["Catalysis of the reaction: copal-8-ol diphosphate <=> 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45181", "l": "2 (E)-4-coumaroyl-CoA + spermidine => 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30116", "l": "decanoyl-[ACP] + H2O => decanoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22647", "l": "O2 + protopine + reduced [NADPH--hemoprotein reductase] <=> 6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72609", "l": "(E)-sinapoyl-CoA + AMP + H(+) => (E)-sinapoyl-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69118", "l": "3-(4-hydroxyphenyl)pyruvate + glycine => glyoxylate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47231", "l": "docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848939", "l": "PTK6 binds KHDRBS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43237", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O => 1,2-dihexadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58736", "l": "H2O + TTP = 5-methyl-UMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24084", "l": "all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047784", "l": "cortisol O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + cortisol = CoA + cortisol 21-acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210426", "l": "Glutamate synaptic vesicle docking and priming (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71039", "l": "L-methionine(in) + L-phenylalanine(out) = L-methionine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.104", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421515", "l": "uroporphyrinogen III => coproporphyrinogen III + 4 CO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0005178", "l": "integrin binding", "d": ["Binding to an integrin."]}]}
{"type": "biolink:MolecularActivity", "ic": "84.124192141464761", "identifiers": [{"i": "GO:0050486", "l": "intramolecular transferase activity, transferring hydroxy groups", "d": ["Catalysis of the transfer of a hydroxyl group from one position to another within a single molecule."]}, {"i": "EC:5.4.4.-", "l": "\"Transferring hydroxy groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938930", "l": "RUNX1 binds ELF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24815", "l": "3-methyl-2-oxobutanoate + L-glutamate => 2-oxoglutarate + L-valine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34813", "l": "dihydrocurcumin + H(+) + NADPH => NADP(+) + tetrahydrocurcumin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34011", "l": "5-dehydroepisterol + 2 H2O + NADP(+) = ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64844", "l": "(2E)-geraniol + benzoyl-CoA = (2E)-geranyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20893", "l": "butanoyl-CoA + phosphate => butanoyl phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68610", "l": "Formation of ORC(2-5) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696605", "l": "USP12, USP26 deubiquitinate AR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68577", "l": "ATP + H2O + xanthine(out) => ADP + H(+) + phosphate + xanthine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102549", "l": "1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + H2O <=> sn-1-lyso-2-16:0-monogalactosyldiacylglycerol + oleate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58867", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47742", "l": "CO2 + demethylphylloquinone + diphosphate => 1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015594", "l": "ABC-type putrescine transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + putrescine(out) -> ADP + phosphate + putrescine(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-994148", "l": "LRRC16A binds F-actin capping protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58500", "l": "glycine betaine + H(+) + NADH + O2 = glyoxylate + H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9629679", "l": "PDE3A inhibitors bind PDE3A (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55974", "l": "CoA + ethyl acetate => acetyl-CoA + ethanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9709179", "l": "DPP4 binds DPP4 inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266328", "l": "CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863463", "l": "STON2 binds SYT proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034812", "l": "9,10-dihydroxybenzo(a)pyrene dioxygenase activity", "d": ["Catalysis of the reaction: 9,10-dihydroxybenzo(a)pyrene + O2 = cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2512800", "l": "SCARB1:ligand is endocytosed (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.264511229695032", "identifiers": [{"i": "GO:0000977", "l": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "d": ["Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33190", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14499", "l": "AH2 + isopyridoxal => A + pyridoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202969", "l": "Caspase mediated cleavage of beta-catenin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30996", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59522", "l": "(2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate => ATP + butanoyl-CoA + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52724", "l": "3'-phosphoadenylyl sulfate + an aliphatic (Z)-desulfo-glucosinolate = a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + adenosine 3',5'-bisphosphate + H(+)", "d": []}, {"i": "EC:2.8.2.38", "l": "\"aliphatic desulfoglucosinolate sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.128", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9007901", "l": "IL1F10 binds IL1RL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046965", "l": "nuclear retinoid X receptor binding", "d": ["Binding to a nuclear retinoid X receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69632", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418579", "l": "Gq activation by P2Y purinoceptor 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37741", "l": "1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57480", "l": "2-hydroxydodecanoate + H2O2 = 2,3-dihydroxydodecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51595", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene <=> benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693081", "l": "FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451418", "l": "Pellino ubiquitinates IRAK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389354", "l": "Activation of Vav1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264435", "l": "Dissociation of the COP1-p53 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350604", "l": "Agmatine + H2O <=> putrescine + urea (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38509", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938913", "l": "RUNX1 binds ELF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56556", "l": "(2E,6E)-farnesyl diphosphate = delta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17332", "l": "(1R,2S,4R)-borneol + NAD(+) <=> (1R,4R)-camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0051032", "l": "nucleic acid transmembrane transporter activity", "d": ["Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44035", "l": "9,10-epoxy-(12Z)-octadecenoate + H2O <=> 9,10-dihydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20985", "l": "a sphingomyelin + H2O => an N-acylsphing-4-enine 1-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61297", "l": "5-deoxy-alpha-D-ribose 1-phosphate => 5-deoxy-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163320", "l": "Association of mTERF with the termination sequence (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66939", "l": "(E)-caffeoyl-CoA + 5-hydroxyanthranilate <=> avenanthramide C + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57697", "l": "ATP + cob(I)inamide-[corrinoid adenosyltransferase] => adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140486", "l": "zinc ion sequestering activity", "d": ["Binding to a zinc ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198611", "l": "AKT phosphorylates IKKalpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32179", "l": "(S)-2,3-dihydrodipicolinate + NAD(+) = dipicolinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018818", "l": "acetylene hydratase activity", "d": ["Catalysis of the reaction: acetaldehyde = acetylene + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216040", "l": "Collagen type IV networks bind integrins alpha1beta1, alpha2beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22406", "l": "D-galactaro-1,5-lactone + H(+) + NADH => beta-D-galacturonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983422", "l": "Disassembly of COPII coated vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41526", "l": "5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol => 5 H(+) + 5 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12062", "l": "3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O => acetyl-CoA + 5 H(+) + 6 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20794", "l": "AMP + diphosphate + L-lysyl-tRNA(Lys) => ATP + L-lysine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17751", "l": "AH2 + quinolin-2(1H)-one => A + H2O + quinoline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14633", "l": "ATP + H2O + Na(+)(in) = ADP + H(+) + Na(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12280", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.149", "l": "\"1-phosphatidylinositol-5-phosphate 4-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28136", "l": "(2S)-hesperetin + rutinose => (2S)-hesperidin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.1", "l": "\"cathepsin B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052769", "l": "beta-6-sulfate-N-acetylglucosaminidase activity", "d": ["Catalysis of the glycosidic cleavage of the terminal 2-acetamido-2-deoxy-beta-D-glucopyranoside 6-sulfate (6-SO3-GlcNAc) residue from sulfomucin, a sulfated mucin derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25307", "l": "7,8-dihydroneopterin + phosphate => 7,8-dihydroneopterin 3'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50410", "l": "2-heptyl-4(1H)-quinolone + H2O => 1-(2-aminophenyl)decane-1,3-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44048", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13312", "l": "H2O + NAD(+) + vanillin <=> 2 H(+) + NADH + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46178", "l": "2-methylpropanoyl-CoA + AMP + diphosphate => 2-methylpropanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31109", "l": "(2-hydroxyphenyl)acetate + CO2 => 3-phenylpyruvate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15334", "l": "(S)-ureidoglycolate + NADP(+) => H(+) + N-carbamoyl-2-oxoglycine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25055", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 => (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73757", "l": "Binding of RRN3 to RNA Polymerase I (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159773", "l": "Furin cleaves pro-protein S to protein S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40870", "l": "(9E)-octadecenoyl-CoA + FAD + H(+) <=> (2E,9E)-octadecadienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18868", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA <=> (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10912", "l": "(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.2.1", "l": "\"pantoate--beta-alanine ligase (AMP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66073", "l": "4-methyl-2-oxopentanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0004915", "l": "interleukin-6 receptor activity", "d": ["Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2179413", "l": "Activated PKC-alpha  activate MMP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11843", "l": "benzaldehyde + H2O + NAD(+) <=> benzoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45961", "l": "24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75555", "l": "(-)-cyatha-3,12-diene + O2 + reduced [NADPH--hemoprotein reductase] = erinacol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879907", "l": "Tyrosine kinases phosphorylate the receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008446", "l": "GDP-mannose 4,6-dehydratase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54625", "l": "2-oxoglutarate + O2 + octadecanoyl-CoA => 2-hydroxyoctadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.21", "l": "\"aspartyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35189", "l": "(Z)-3-aminoacrylate + A + H(+) + H2O => (Z)-3-aminoperacrylic acid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35728", "l": "dodecanoyl-CoA + sn-glycerol 3-phosphate => 1-dodecanoyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990137", "l": "plant seed peroxidase activity", "d": ["Catalysis of the reaction: R1H + R2OOH = R1OH + R2OH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25005", "l": "L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68530", "l": "beta-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804762", "l": "TP53 forms homotetramers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43566", "l": "[5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate => 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5681980", "l": "ATG12 binds ATG7 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45372", "l": "H2O + N-(9Z-octadecenoyl)-sphinganine = (9Z)-octadecenoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684282", "l": "nsp9 forms a homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56967", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate <=> a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29791", "l": "ATP + glutathione(out) + H2O = ADP + glutathione(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.4.2.10", "l": "\"ABC-type glutathione transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786155", "l": "POLN binds ICL-DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610653", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors bind to postsynaptic density proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64069", "l": "(R)-phenylacetylcarbinol + NAD(+) => 1-phenyl-1,2-propanedione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30399", "l": "alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase] = alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51466", "l": "1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => deoxycholate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.527524213458875", "identifiers": [{"i": "GO:0016675", "l": "oxidoreductase activity, acting on a heme group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}, {"i": "EC:1.9.-.-", "l": "\"Acting on a heme group of donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17434", "l": "A + choline => AH2 + betaine aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68733", "l": "ganoderate DM + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hainanate A + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0018455", "l": "alcohol dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46125", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32292", "l": "phosphoethanolamine + 3 S-adenosyl-L-methionine => 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810392", "l": "TMEM55B translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.2", "l": "\"exodeoxyribonuclease III\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714481", "l": "RAC2 binds effectors at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75166", "l": "NAD(+) + UTP <=> H(+) + NADP(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16839", "l": "a carboxylate + AMP + 2 H(+) => 5'-acylphosphoadenosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.164", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21166", "l": "a carboxylate + an alcohol + H(+) => a carboxylic ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434058", "l": "LPS binding to Toll like receptor 4 results in dimerization of the TLR4 associated with LY96 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23454", "l": "ADP + dAMP + H(+) => 2'-deoxyadenosine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41419", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61882", "l": "1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47535", "l": "chenodeoxycholate + NAD(+) <=> 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.207", "l": "\"xyloglucan:xyloglucosyl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13815", "l": "cis-1,2-dihydrobenzene-1,2-diol + NAD(+) => benzene + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38094", "l": "delta-tocotrienol + S-adenosyl-L-methionine <=> beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16612", "l": "AMP + diphosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805109", "l": "CDK2 phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3364014", "l": "Recruitment of SET1 methyltransferase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "57.987279616643796", "identifiers": [{"i": "GO:0005102", "l": "signaling receptor binding", "d": ["Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50616", "l": "NADP(+) + nonan-2-one = (3E)-nonen-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33889", "l": "(-)-matairesinol + 2 H(+) + 2 NADH => (-)-secoisolariciresinol + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66895", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37824", "l": "(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 => 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21603", "l": "anthranilate + benzoyl-CoA <=> CoA + N-benzoylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43355", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798528", "l": "S100A8:S100A9 binds Mn2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227881", "l": "Phosphorylation and release of IRF3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029270", "l": "Recruitment of PLCgamma to membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391158", "l": "SIRP alpha binds CD47 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12421", "l": "ATP + D-tagatofuranose 6-phosphate => ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18748", "l": "2 juglone + O2 <=> 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17535", "l": "an aromatic oxo-acid + L-glutamate => 2-oxoglutarate + an aromatic L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009815", "l": "1-aminocyclopropane-1-carboxylate oxidase activity", "d": ["Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 = CO2 + dehydroascorbate + ethylene + 2 H2O + hydrogen cyanide. Ethene is also known as ethylene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23060", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP = a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate", "d": []}, {"i": "EC:6.1.3.1", "l": "\"olefin beta-lactone synthetase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802933", "l": "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73745", "l": "2 H(+)(in) + serotonin(out) => 2 H(+)(out) + serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954056", "l": "E2F6 binds TFDP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5634228", "l": "TRAF1 is cleaved by caspases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30340", "l": "H(+) + L-tryptophan => CO2 + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664567", "l": "ERBB2 KD mutants heterodimerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50223", "l": "(S)-demethyl-4-deoxygadusol <=> (R)-demethyl-4-deoxygadusol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182988", "l": "Sprouty lures CBL away from EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47526", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => cholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865107", "l": "MICAL1 produces NADP+, H2O2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69154", "l": "acrolein + spermidine => spermine monoaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674427", "l": "PDGFR mutants bind type I TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67462", "l": "AH2 + oxaloacetate => (R)-malate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-912790", "l": "CBL binds CRK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202241", "l": "Recruitment of SLP-76 to Gads (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5099899", "l": "WNT5A binds FZD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70342", "l": "alpha-D-Gal-(1->6)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O <=> beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35044", "l": "N-(4-aminobenzoyl)-L-glutamate(in) => N-(4-aminobenzoyl)-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168947", "l": "Ligand binds to TLR10 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432067", "l": "Aquaporin-4 passively transports water out of cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22329", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) => diphosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36711", "l": "ATP + H(+) + H2O + O-ureido-D-serine = ADP + CO2 + D-cycloserine + NH4(+) + phosphate", "d": []}, {"i": "EC:6.3.3.5", "l": "\"O-ureido-D-serine cyclo-ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654409", "l": "Activated FGFR3 binds FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59972", "l": "decanoyl-CoA + L-seryl-[protein] = CoA + O-decanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109701", "l": "PDPK1 binds PIP3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062047", "l": "pipecolic acid N-hydroxylase", "d": ["Catalysis of the reaction: L-pipecolic acid + NAD(P)H + O2 + H+ = N-hydroxypipecolic acid + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39661", "l": "1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12211", "l": "4-methylumbelliferyl acetate + H2O <=> 4-methylumbelliferone + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60017", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + sesquisabinene B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38690", "l": "(4R)-hydroxysphinganine(in) + ATP + H2O <=> (4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71926", "l": "2 Na(+)(out) + taurochenodeoxycholate(out) <=> 2 Na(+)(in) + taurochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19340", "l": "2 hydroxylamine + 2 NAD(+) <=> 2 H(+) + hyponitrous acid + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661217", "l": "MT1A binds zinc (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52528", "l": "2-oxoglutarate + L-asparagine = 2-oxosuccinamate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010541", "l": "ISL1 binds the SLIT2 gene enhancer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61737", "l": "steviolmonoside + UDP-alpha-D-glucose => rubusoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008960", "l": "phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity", "d": ["Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450348", "l": "Activated human JNKs migrate to nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950057", "l": "IL12RB1 binds TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807106", "l": "PTEN undergoes monoubiquitination (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.2.-", "l": "\"Amide--thiol ligases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58489", "l": "4-(trimethylamino)butanoate + H(+) + NADH + O2 => H2O + NAD(+) + succinate semialdehyde + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73894", "l": "ATP + L-glutamate + spermidine <=> ADP + gamma-L-glutamylspermidine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030410", "l": "nicotianamine synthase activity", "d": ["Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5'-thioadenosine + 3 H+ + nicotianamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40051", "l": "chorismate = 3-[(1-carboxyvinyl)-oxy]benzoate + H2O", "d": []}, {"i": "EC:4.2.1.151", "l": "\"chorismate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047183", "l": "anthocyanin 5-aromatic acyltransferase activity", "d": ["Catalysis of the reaction: anthocyanidin-3,5-diglucoside + hydroxycinnamoyl-CoA = anthocyanidin 3-glucoside-5-hydroxycinnamoylglucoside + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1248694", "l": "Trans-autophosphorylation of ERBB2 homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.70", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783530", "l": "gp130:JAKs bind CNTFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67550", "l": "[protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43556", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044197", "l": "Rel homology domain binding", "d": ["Binding to a Rel Homology Domain (RHD) of a protein. The RHD is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish and NFAT."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64840", "l": "2-phenylethanol + benzoyl-CoA = CoA + phenethyl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40712", "l": "1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873850", "l": "STARD5 binds DCA, LCA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013711", "l": "HES1 gene expression is stimulated by NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.253", "l": "\"baicalein 7-O-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19576", "l": "[phosphate](n) + ATP <=> [phosphate](n+1) + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036463", "l": "TRAIL receptor activity", "d": ["Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic cell death."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71151", "l": "4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one = (E)-caffeoylpyruvate + CO2 + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141367", "l": "Myristoylation of tBID by NMT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.28", "l": "\"phenylsuccinyl-CoA transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24476", "l": "H2O + maleimide = H(+) + maleamate", "d": []}, {"i": "EC:3.5.2.16", "l": "\"maleimide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008993", "l": "rhamnulokinase activity", "d": ["Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062205", "l": "miltiradiene synthase activity", "d": ["Catalysis of the reaction: (+)-copalyl diphosphate = diphosphate + miltiradiene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1006169", "l": "Factor H binds host cell surface markers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176517", "l": "SULTs transfer (SO4)2- group to PREG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12508", "l": "loganate + S-adenosyl-L-methionine = loganin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.50", "l": "\"loganate O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67715", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641111", "l": "Parkin transfers Ub to misfolded proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-179410", "l": "Association of Nek2A with MCC:APC/C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63744", "l": "UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan-1-N-beta-D-glucuronide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74729", "l": "5 CO2 + 6 CoA + dodecapentaneoyl-[polyketide synthase] + 5 H2O + 5 NADP(+) => acetyl-CoA + 10 H(+) + holo-[polyketide synthase] + 5 malonyl-CoA + 5 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379980", "l": "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31989", "l": "baruol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033841", "l": "6G-fructosyltransferase activity", "d": ["Catalysis of the reaction: [1-beta-D-fructofuranosyl-(2->1)-]m+1 alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 alpha-D-glucopyranoside = [1-beta-D-fructofuranosyl-(2->1)-]m alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 beta-D-fructofuranosyl-(2->6)-alpha-D-glucopyranoside (m > 0; n >= 0)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693540", "l": "MRN activates ATM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38233", "l": "1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA => (9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036356", "l": "cyclic 2,3-diphosphoglycerate synthetase activity", "d": ["Catalysis of the reaction: 2,3-diphosphoglycerate (DPG) + ATP = cyclic 2,3-diphosphoglycerate (cDPG) + ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027033", "l": "Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68611", "l": "Formation of ORC(1-5) complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6795290", "l": "TORC2 complex phosphorylates SGK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62559", "l": "3,4-dihydroxyphenylacetate + H(+) <=> 4-methylcatechol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44837", "l": "globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose => globoside NOR2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.171", "l": "\"rhamnogalacturonan hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59168", "l": "ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate = AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36937", "l": "(9Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56516", "l": "Fe-coproporphyrin III + 2 H(+) + 2 H2O2 = 2 CO2 + 4 H2O + heme b", "d": []}, {"i": "EC:1.3.98.5", "l": "\"hydrogen peroxide-dependent heme synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22656", "l": "CDP-ethanolamine + L-serine = CMP + H(+) + L-serine-phosphoethanolamine", "d": []}, {"i": "EC:2.7.8.4", "l": "\"serine-phosphoethanolamine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73499", "l": "3',4',7-trihydroxyflavone + S-adenosyl-L-methionine = 4',7-dihydroxy-3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2317314", "l": "AKT binds PDPK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12370", "l": "2,5-didehydro-D-gluconate + AH2 => 2-dehydro-D-gluconate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29992", "l": "H(+)(in) + L-lyxopyranose(in) => H(+)(out) + L-lyxopyranose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70917", "l": "guanosine(out) + H(+)(out) => guanosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47524", "l": "cholate + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873946", "l": "OTUD3 deubiquitinates PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11755", "l": "acetylsalicylate + H2O <=> acetate + H(+) + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47279", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53024", "l": "a plastoquinone + H2O + L-arginine = 5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74032", "l": "L-alanine(in) + L-cysteine(out) => L-alanine(out) + L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373716", "l": "DCC interacting NCK-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83788", "l": "Binding of TFIIIC to Type 2 promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72010", "l": "succinate(in) + urate(out) <=> succinate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54714", "l": "3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52465", "l": "17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40200", "l": "hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15885", "l": "NADP(+) + propane-1,2-diol = (S)-lactaldehyde + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.55", "l": "\"lactaldehyde reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43669", "l": "ATP + hexacosanoyl-CoA + hydrogencarbonate => 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62229", "l": "(E)-ascladiol + A => AH2 + patulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928657", "l": "MMP2,9 cleave EPHB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002440", "l": "Removal of fibrillar collagen C-propeptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0019156", "l": "isoamylase activity", "d": ["Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71713", "l": "H(+)(in) + L-tyrosylglycine(in) => H(+)(out) + L-tyrosylglycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62439", "l": "L-lyxonate <=> 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39895", "l": "7-deoxyloganetate + UDP-alpha-D-glucose = 7-deoxyloganate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.323", "l": "\"7-deoxyloganetic acid glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31658", "l": "4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O <=> 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72781", "l": "FAD + 2 H2O + ochratoxin A => chloride + FADH2 + O2 + ochratoxin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399941", "l": "Rac1 binds PlexinA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49388", "l": "UDP-alpha-D-glucose + validoxylamine A = H(+) + UDP + validamycin A", "d": []}, {"i": "EC:2.4.1.338", "l": "\"validoxylamine A glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022073", "l": "Procollagen triple helix formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662647", "l": "MT4 binds copper (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61102", "l": "(2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64259", "l": "dodecanoyl-CoA + glycine <=> CoA + H(+) + N-dodecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30221", "l": "dimethyl sulfone + H(+) + NADH => dimethyl sulfoxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804762", "l": "TP53 forms homotetramers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0016699", "l": "oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein."]}, {"i": "EC:1.12.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21547", "l": "(2E,6E)-farnesyl diphosphate + ATP <=> (2E,6E)-farnesyl triphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21258", "l": "5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate => 3-phosphoshikimate + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17279", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O => 6-phospho-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033728", "l": "divinyl chlorophyllide a 8-vinyl-reductase activity", "d": ["Catalysis of the reaction: chlorophyllide a + NADP+ = divinyl chlorophyllide a + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694580", "l": "nsp8 binds MAP1LC3B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-532603", "l": "Nephrin mediated activation of N-WASP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374251", "l": "DARC  is a non-specific receptor for many chemokines (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48188", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102321", "l": "2,2'-hydroxybiphenyl monooxygenase activity", "d": ["Catalysis of the reaction: biphenyl-2,2'-diol + O2 + NADH + H+ <=> biphenyl-2,2',3-triol + H2O + NAD."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40580", "l": "1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68526", "l": "beta-bisabolene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67938", "l": "a 2-oxocarboxylate + H2O2 => a 2-hydroxy carboxylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67069", "l": "AH2 + chermesin D methyl ester => A + asnovolin J", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647977", "l": "ICMT methylates S-Farn RAS proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30125", "l": "H(+) + holo-[ACP] + tetradecanoate => H2O + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609737", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN2D (GRIN2D) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30308", "l": "7-methylxanthine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354077", "l": "Integrin alphaIIb beta3 activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174916", "l": "Formation of N-glucuronides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40560", "l": "dTDP-beta-L-evernosamine + NADPH + O2 => dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50671", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60889", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O => (N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18997", "l": "CTP + H(+) + phosphocholine = CDP-choline + diphosphate", "d": []}, {"i": "EC:2.7.7.15", "l": "\"choline-phosphate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23845", "l": "ATP + sedoheptulose => ADP + D-sedoheptulose 7-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48116", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.322", "l": "\"type IV protein arginine methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23669", "l": "apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin => AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868118", "l": "MAPK12 phosphorylates PTPN3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002951", "l": "leukotriene-C(4) hydrolase", "d": ["Catalysis of the reaction leukotriene C(4) + H2O= leukotriene D(4) + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602454", "l": "proMMP9 binds TIMP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005121", "l": "Toll binding", "d": ["Binding to a Toll protein, a transmembrane receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "67.426153789046865", "identifiers": [{"i": "GO:0016769", "l": "transferase activity, transferring nitrogenous groups", "d": ["Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.6.-.-", "l": "\"Transferring nitrogenous groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50942", "l": "cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe) => L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11754", "l": "acetate + H(+) + salicylate => acetylsalicylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48353", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72322", "l": "n chloride(in) + urate(out) <=> n chloride(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31737", "l": "3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 3-oxocholan-24-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70180", "l": "2 D-maltotetraose => alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879930", "l": "STAT5 is recruited by JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.11", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050234", "l": "pyrazolylalanine synthase activity", "d": ["Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34450", "l": "dTDP-6-deoxy-beta-L-talose + NAD(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31644", "l": "mycinamicin VI + S-adenosyl-L-methionine => H(+) + mycinamicin III + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53520", "l": "1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3965450", "l": "DAAM1 recruits PFN1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73534", "l": "CTP(out) + UTP(in) <=> CTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654167", "l": "Activated FGFR1 binds PLCG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24607", "l": "7-methylxanthine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41892", "l": "(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093342", "l": "SDC2 multimerises (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21919", "l": "an aliphatic amine + 2 Fe(III)-[cytochrome c550] + H2O <=> an aldehyde + 2 Fe(II)-[cytochrome c550] + 2 H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9639286", "l": "RRAGC,D exchanges GTP for GDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65609", "l": "(4R)-hydroxysphinganine + docosanoyl-CoA => CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14235", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CoA => a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856945", "l": "PP2A methylation by LCMT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21802", "l": "all-trans-zeaxanthin + H2O + L-dehydroascorbate => all-trans-antheraxanthin + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209840", "l": "Two DITs combine to form thyroxine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421835", "l": "trans-Golgi Network Vesicle Scission (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444647", "l": "C3a receptor binds anaphylatoxin C3a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63740", "l": "2-phenylacetaldehyde + H(+) + NADH = 2-phenylethanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.81", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75738", "l": "10-oxo-(12Z)-octadecenoate <=> 10-oxo-(11E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60222", "l": "CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50481", "l": "acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693558", "l": "Gap-filling DNA synthesis in SDSA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73129", "l": "4',8-dihydroxy-7-methoxyflavone + S-adenosyl-L-homocysteine => 4',7,8-trihydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49918", "l": "(R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182990", "l": "Sprouty sequesters CBL away from active EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61405", "l": "ATP + N-(D-ribulosyl)-cadaverine => ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761344", "l": "USP18 binds IKBKG within IKK complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18914", "l": "a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74707", "l": "Binding of IRS to insulin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090588", "l": "protein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylmuramate (out) = protein cysteine + N-acetylmuramate-6-phosphate (in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046568", "l": "3-methylbutanol:NAD(P) oxidoreductase activity", "d": ["Catalysis of the reaction: 3-methylbutanol + NAD(P)+ = 3-methylbutanal + NAD(P)H + H+. 3-methylbutanal is also known as isovaleraldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328037", "l": "Fibrillin-1 binds integrins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693012", "l": "TNFSF15 binds TNFRSF25 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10608", "l": "(E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase] = (E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.91", "l": "\"trans-cinnamate 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990447", "l": "U2 snRNP binding", "d": ["Binding to a U2 small nuclear ribonucleoprotein particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64328", "l": "(7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043210", "l": "alkanesulfonate binding", "d": ["Binding to alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429449", "l": "Syk activation leads to SLP-76 activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050603", "l": "thiophene-2-carbonyl-CoA monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + O2 + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H2O + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47704", "l": "H(+) + iso-precytochalasin + NADPH + O2 = cytochalasin Z16 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.57", "l": "\"heme oxygenase (mycobilin-producing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65921", "l": "L-kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809793", "l": "MTMR2 binds SBF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432067", "l": "Aquaporin-4 passively transports water out of cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2002401", "l": "Association of procollagen type XVIII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66422", "l": "ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out) => ATP + glutathione(in) + H2O + tauroursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944219", "l": "Association of procollagen type XVI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551648", "l": "SUMOylation of TDG with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1640164", "l": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48679", "l": "6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.726388927917483", "identifiers": [{"i": "GO:0042805", "l": "actinin binding", "d": ["Binding to actinin, any member of a family of proteins that crosslink F-actin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53443", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201622", "l": "Caspase-mediated cleavage of gelsolin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54817", "l": "L-glutaminyl-[protein] + L-lysyl-[protein] => [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30746", "l": "beta-nicotinamide D-riboside + H2O <=> D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2090079", "l": "GLB1 hydrolyses linker chain(2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27677", "l": "ATP + dADP <=> ADP + dATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33488", "l": "(4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA => CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69789", "l": "3-(2-aminophenyl)succinyl-CoA + succinate => (2-aminophenyl)succinate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296127", "l": "Activation of voltage gated Potassium channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55241", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O => (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351913", "l": "Caspase-mediated cleavage of TJP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672969", "l": "Phosphorylation of RAF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21975", "l": "precorrin-1 + S-adenosyl-L-methionine <=> precorrin-2 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389523", "l": "BTLA interacts with HVEM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75215", "l": "beta-L-fucose + NADP(+) = H(+) + L-fucono-1,5-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56276", "l": "ATP + L-proline = 3'-L-prolyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1028820", "l": "Formation of VAF (virus-activated factor) complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50749", "l": "H2O + juglone => naphthalene-1,2,4,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27810", "l": "dimethylallyl diphosphate + 2 isopentenyl diphosphate = (2Z,6Z)-farnesyl diphosphate + 2 diphosphate", "d": []}, {"i": "EC:2.5.1.92", "l": "\"(2Z,6Z)-farnesyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592297", "l": "Full activation of MMP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350477", "l": "RHOGEF2 stimulates nucleotide exchange of RHO1:GDP complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626928", "l": "CREBBP binds FOXO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981610", "l": "Neuroglobin binds oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-874087", "l": "SGT1 binds HSP90 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22923", "l": "L-glutamine + scyllo-inosose <=> 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41784", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)/18:0) = CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38185", "l": "19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141159", "l": "TNF-mediated dimerization of procaspase-8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26049", "l": "glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27668", "l": "CO2 + propanoyl-CoA => (R)-methylmalonyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44888", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0035240", "l": "dopamine binding", "d": ["Binding to dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62723", "l": "3 H(+) + 3 NADPH + 3 O2 + probetaenone I <=> betaenone B + 3 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35638", "l": "an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54433", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 => a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26039", "l": "beta-D-fructose 6-phosphate + GDP-alpha-D-mannose = beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.246", "l": "\"mannosylfructose-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67893", "l": "3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine => 3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947535", "l": "Cyclisation of GTP to precursor Z (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004106", "l": "chorismate mutase activity", "d": ["Catalysis of the reaction: chorismate = prephenate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69989", "l": "(22S)-22-hydroxycampest-4-en-3-one + H(+) + NADPH => (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19764", "l": "FMN-N(5)-oxide + H(+) + NADH <=> FMN + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390835", "l": "DRD1,5 bind DA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10896", "l": "2 H2O + limonin = 2 H(+) + limonoate", "d": []}, {"i": "EC:3.1.1.36", "l": "\"limonin-D-ring-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72113", "l": "L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in) => L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.821724717432701", "identifiers": [{"i": "GO:0140083", "l": "ATP-dependent protein-DNA unloader activity", "d": ["Facilitating the removal of a protein or protein complex from a DNA molecule driven by ATP hydrolysis. This can be achieved for example by introducing non-canonical DNA structures or generating torque to directly inhibit a protein-DNA binding interaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46565", "l": "acetyl-CoA + apo-[ACP] => acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193653", "l": "NGF homodimer binds to p75NTR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75824", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] => 5-oxo-(6E,8Z)-octadecadienoate + H(+) + 2 H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.232587076149059", "identifiers": [{"i": "GO:0070003", "l": "threonine-type peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351948", "l": "Mitochondrial recruitment of Drp1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44617", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17250", "l": "2 Fe(2+) + 2 H2O + H2O2 => 6 H(+) + 2 iron(III) oxide-hydroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430190", "l": "p-SLP-76 binds NCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50998", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine => L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10769", "l": "(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 => (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23560", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388605", "l": "POMC(138-176) binds MC2R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33776", "l": "a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160053", "l": "serine-based site-specific recombinase activity", "d": ["Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphoseryl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a serine in the active site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48117", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592297", "l": "Full activation of MMP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390835", "l": "DRD1,5 bind DA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388596", "l": "Melanocortin receptors bind melanocortins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102654", "l": "1-18:1-2-16:0-phosphatidylglycerol trans-3 desaturase activity", "d": ["Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor <=> 1-18:1-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69032", "l": "N,N-dihydroxy-L-aspartate = (2S)-2-nitrosobutanedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44853", "l": "(5Z)-tetradecenoyl-CoA + (R)-carnitine => CoA + O-(5Z)-tetradecenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684052", "l": "PIAS4 SUMOylates MDC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41880", "l": "(2E)-dodecenoyl-[ACP] + H(+) + NADPH = dodecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166726", "l": "Activation of MASPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11067", "l": "beta-D-fructose 1,6-bisphosphate + H2O <=> beta-D-fructose 6-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43586", "l": "5-guanidino-2-oxopentanoate + NH4(+) => H2O + iminoarginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18134", "l": "ATP + H(+) + sulfate => adenosine 5'-phosphosulfate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67918", "l": "AMP + NH4(+) => adenosine 5'-phosphoramidate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75327", "l": "chloride(out) + D-tryptophan(out) + 2 Na(+)(out) = chloride(in) + D-tryptophan(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44083", "l": "ATP + CoA + undecanoate <=> AMP + diphosphate + undecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218805", "l": "PKC autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667965", "l": "ANKLE2 binds PP2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371582", "l": "HSBP1 binds HSF1 trimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45789", "l": "(9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol => 1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33236", "l": "2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 => 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66953", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose => alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54644", "l": "trans-4-hydroxy-L-proline = (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": []}, {"i": "EC:4.2.1.172", "l": "\"trans-4-hydroxy-L-proline dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222237", "l": "SMYD2 methylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25170", "l": "6-oxohexanoate + H(+) => 6-hydroxyhexan-6-olide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691421", "l": "BTK binds BTK inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879594", "l": "SLCO4C1 mediates the transport of digoxin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678854", "l": "S1PR1 binds S1PR1 agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76094", "l": "(11R)-19-hydroxycarlactone + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-19-oxocarlactone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418553", "l": "cAMP degradation by Phosphodiesterases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49716", "l": "3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 = 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.223", "l": "\"3-hydroxy-4-methyl-anthranilyl-[aryl-carrier protein] 5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14442", "l": "acetyl-CoA + gentamicin C => CoA + H(+) + N(3)-acetylgentamycin C", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050380", "l": "undecaprenyl-diphosphatase activity", "d": ["Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482772", "l": "Release of platelet cytosolic components (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44234", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1474210", "l": "Collagen type III degradation by MMP14 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990471", "l": "piRNA uni-strand cluster binding", "d": ["Binding to uni-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) that map predominantly to only one strand and exhibit hallmarks of canonical Pol II transcription. Uni-strand piRNA clusters are found in many taxa."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30751", "l": "ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46799", "l": "an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33024", "l": "6-phospho-D-gluconate + NAD(+) => CO2 + D-ribulose 5-phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647680", "l": "CASP1 cleaves GSDMD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849878", "l": "PSD-95 binds NMDA receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9612501", "l": "SGK phosphorylates CREB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52830", "l": "(3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-isodihydrocarvone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66472", "l": "(2Z,6E,10E,14E)-geranylfarnesol = 18-episcalar-17(25)-en-19-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33941", "l": "H2O + N(omega)-hydroxy-L-arginine + NAD(+) => H(+) + L-arginine + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74707", "l": "Binding of IRS to insulin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75434", "l": "32-hydroxyeburicol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-oxoeburicol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63792", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818682", "l": "MEN1 binds MLL2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29439", "l": "Fe(2+)(in) + H(+)(out) = Fe(2+)(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56925", "l": "ATP + L-threonyl-[Goodpasture antigen-binding protein] => ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102505", "l": "apigeninidin 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: apigeninidin + UDP-alpha-D-glucose <=> apigeninidin 5-O-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22999", "l": "H2O2 + L-ascorbate <=> 2 H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-976768", "l": "Factor H binds to C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21240", "l": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61941", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose => 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52772", "l": "7,8-dihydroneopterin 3'-triphosphate = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate", "d": []}, {"i": "EC:4.1.2.60", "l": "\"dihydroneopterin triphosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46182", "l": "2-methylbutanoyl-CoA + AMP + diphosphate => 2-methylbutanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74783", "l": "tyramine(in) = tyramine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395768", "l": "LPL hydrolyses TGs from mature CMs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848250", "l": "ACBD6 binds LCFA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35403", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) = (3R)-vestitone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11008", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O = a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59392", "l": "acetyl-CoA + L-seryl-[protein] = CoA + O-acetyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37367", "l": "CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine = 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41295", "l": "H2O + N-(hexanoyl)sphing-4-enine = hexanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48331", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose <=> GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708889", "l": "SARS-CoV-2 6 binds NUP98:RAE1 within NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19885", "l": "(S)-reticuline + O2 = (S)-scoulerine + H(+) + H2O2", "d": []}, {"i": "EC:1.21.3.3", "l": "\"reticuline oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52579", "l": "hexanoyl-CoA + NAD(+) <=> (2E)-hexenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57078", "l": "(2R)-3-phosphoglycerate + glycolate + H(+) => 3-oxoisoapionate 4-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46533", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16541", "l": "9-cis-violaxanthin + O2 = (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53174", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358790", "l": "RNF41 ubiquitinates ERBB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76052", "l": "Binding of TFIIIA To type 1 Promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39406", "l": "(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH <=> (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38849", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18482", "l": "cyclohexylsulfamate + H2O => cyclohexylamine + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.38", "l": "\"gametolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167083", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19647", "l": "a D-threo-aldono-1,5-lactone + H(+) + NADH => a D-threo-aldose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62221", "l": "phyllostine => neopatulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31054", "l": "(3R)-beta-leucine + H2O + NAD(+) <=> 4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029272", "l": "Release of PLCG from FCGR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10517", "l": "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) => (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23760", "l": "H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) = reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.12.98.1", "l": "\"coenzyme F420 hydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0050307", "l": "sucrose-phosphate phosphatase activity", "d": ["Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13913", "l": "L-threonine = D-threonine", "d": []}, {"i": "EC:5.1.1.6", "l": "\"threonine racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28030", "l": "[thioredoxin]-disulfide + dGDP + H2O = [thioredoxin]-dithiol + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36793", "l": "hydroxyurea + L-ornithine => H2O + N(omega)-hydroxy-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296045", "l": "Activation of Potassium transport channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607756", "l": "TRAF6 oligomer autoubiquitinates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824181", "l": "Expression of LFNG in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0043047", "l": "single-stranded telomeric DNA binding", "d": ["Binding to single-stranded telomere-associated DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20611", "l": "glycolaldehyde + pyruvate => 2-dehydro-3-deoxy-D-arabinonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70877", "l": "L-glutamine(out) + L-methionine(in) + Na(+)(in) => L-glutamine(in) + L-methionine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936380", "l": "Interaction of PIN1 with p-IRF3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57454", "l": "H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine => L-glutaminyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71875", "l": "2 Na(+)(out) + taurocholate(out) = 2 Na(+)(in) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23317", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 => 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37075", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.8.4.5", "l": "\"tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54111", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + guaia-4,6-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110244", "l": "Excision of FapyG by OGG1 glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021596", "l": "Membrane estrogen receptors bind SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67466", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine => H2O + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10007", "l": "benzyl isothiocyanate <=> benzyl thiocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64910", "l": "CMP + 2 H(+) + 2 phosphate => CTP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72185", "l": "mRNA polyadenylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52477", "l": "estrone + UDP-alpha-D-glucuronate => estrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1467466", "l": "ABCA4 mediates atRAL transport (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211924", "l": "CYP4B1 12-hydroxylates ARA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61957", "l": "1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49531", "l": "(ethylene terephthalate)(n) + H2O <=> (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45251", "l": "butanoate(out) <=> butanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390929", "l": "HTR1 and 5A receptors can bind serotonin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51338", "l": "8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679780", "l": "SIGMAR1 binds fluvoxamine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53263", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72576", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O => (22R)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11018", "l": "(S)-ureidoglycolate + urea => allantoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43774", "l": "H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1170539", "l": "Prolactin receptor is internalized (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097645", "l": "amylin binding", "d": ["Binding to amylin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56305", "l": "ATP + H2O + rifampicin => 21-phosphorifampicin + AMP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047302", "l": "UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + UDP-2-acetamido-4-amino-2,4,6-trideoxy-D-glucose = L-glutamate + UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9725855", "l": "NR3C2 binds NR3C2 antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74358", "l": "a cytidine in mRNA + H(+) + H2O <=> a uridine in mRNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40818", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10914", "l": "(R)-pantothenate + AMP + diphosphate + H(+) => (R)-pantoate + ATP + beta-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21581", "l": "(2S)-2-acetolactate + H(+) => (R)-acetoin + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211206", "l": "Translocation of DFF to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43124", "l": "guanosine(10) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.213", "l": "\"tRNA (guanine(10)-N(2))-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0019191", "l": "cellobiose transmembrane transporter activity", "d": ["Enables the transfer of cellobiose from one side of a membrane to the other. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018646", "l": "1-hydroxy-2-oxolimonene 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: (1S,4R)-1-hydroxy-2-oxolimonene + NADPH + O2 = NADP+ + OH- + (3R)-3-isopropenyl-6-oxoheptanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63846", "l": "2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O => [thioredoxin]-dithiol + cumene hydroperoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015117", "l": "thiosulfate transmembrane transporter activity", "d": ["Enables the transfer of thiosulfate ions, S2O3(2-), from one side of a membrane to the other."]}, {"i": "RHEA:32807", "l": "thiosulfate(in) = thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44842", "l": "CoA + O-octadecanoyl-(R)-carnitine => (R)-carnitine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50814", "l": "1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33590", "l": "acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate <=> CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12092", "l": "(S)-acetoin = (R)-acetoin", "d": []}, {"i": "EC:5.1.2.4", "l": "\"acetoin racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60072", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 = 4beta-hydroxymethyl-4alpha-methylzymosterol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23871", "l": "(1-hydroxycyclohexan-1-yl)acetyl-CoA <=> acetyl-CoA + cyclohexanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13443", "l": "H(+) + NH4(+) + pyruvate + sulfite => H2O + L-cysteate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103039", "l": "protein methylthiotransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [ribosomal protein S12] L-aspartate89 + a sulfurated [sulfur carrier] + a reduced electron acceptor = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2 H+ + a [ribosomal protein S12] 3-methylthio-L-aspartate89 + an unsulfurated [sulfur carrier] + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426209", "l": "DAG activation of TRPC channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36556", "l": "eicosanoyl-CoA + sphinganine => CoA + H(+) + N-eicosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71576", "l": "5-phosphomethyl-dUMP in DNA + putrescine => 5-N(alpha)-putrescinyl-dTMP in DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42100", "l": "ATP + carbamoyl phosphate + H2O + kanamycin A = 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624949", "l": "Assembly of the anterograde IFT train (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30187", "l": "(S)-dihydroorotate + a quinone = a quinol + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.548113645350185", "identifiers": [{"i": "GO:0008373", "l": "sialyltransferase activity", "d": ["Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46409", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47497", "l": "lithocholate + NADP(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362549", "l": "Hh-Np traffics to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64493", "l": "3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] => dehydrocitreoisocoumarin + H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64313", "l": "2 chloride + 2 FADH2 + 2 O2 + sulochrin => dihydrogeodin + 2 FAD + H(+) + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33224", "l": "2-oxobutanoate + CoA + NAD(+) => CO2 + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047522", "l": "15-oxoprostaglandin 13-oxidase activity", "d": ["Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70481", "l": "TPI1 isomerizes GA3P to DHAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70754", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64300", "l": "3-phenylpropylamine + pyruvate = 3-phenylpropanal + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44309", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine => 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31771", "l": "an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017131", "l": "uridine-rich cytoplasmic polyadenylylation element binding", "d": ["Binding to a U-rich sequence in the 3'-end of nuclear-transcribed mRNAs; required for cytoplasmic polyadenylylation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352059", "l": "SLC6A15-mediated amino acid uptake (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16460", "l": "(2R,3S)-tartrate + NAD(+) <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602473", "l": "Autocatalytic activation of MMP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373147", "l": "succinate + FAD <=> fumarate + FADH2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25690", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) = CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate", "d": []}, {"i": "EC:2.7.7.67", "l": "\"CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67141", "l": "L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2 => H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32725", "l": "(E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029473", "l": "Branching and elongation of mother and daughter filaments (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50363", "l": "(R)-mandelonitrile + O2 <=> benzoyl cyanide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21041", "l": "CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003939", "l": "L-iditol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.410862358716358", "identifiers": [{"i": "GO:0034617", "l": "tetrahydrobiopterin binding", "d": ["Binding to a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.214786017368347", "identifiers": [{"i": "GO:0015085", "l": "calcium ion transmembrane transporter activity", "d": ["Enables the transfer of calcium (Ca) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404200", "l": "IGF1,2 binds IGF1R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24797", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O = (S)-2-amino-6-oxoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047350", "l": "glucuronate-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: 1-phospho-alpha-D-glucuronate + UTP = diphosphate + UDP-alpha-D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67538", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine => (9Z,12Z)-octadecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23219", "l": "benzoyl-CoA + H(+) + NADPH + O2 <=> 3-hydroxybenzoyl-CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40304", "l": "A + dodecanedioyl-CoA => (2E)-dodecenedioyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1297444", "l": "Binding of cAMP to HCN channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65058", "l": "7-oxoglycolithocholate + H(+) + NADPH => glycochenodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49829", "l": "(5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34218", "l": "4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) <=> 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684261", "l": "MAP3K8 is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14551", "l": "2-oxopent-4-enoate + formate + H(+) => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71577", "l": "5-N(alpha)-putrescinyl-dTMP in DNA + phosphate => 5-phosphomethyl-dUMP in DNA + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41992", "l": "17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14838", "l": "glyoxylate + H2O + O2 => H(+) + H2O2 + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8980691", "l": "RHOA GEFs activate RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318590", "l": "Defective MMACHC does not decyanate CNCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10942", "l": "(4R)-limonene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029460", "l": "PAK1 phosphorylates LIMK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70481", "l": "TPI1 isomerizes GA3P to DHAP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35052", "l": "N,N'-diacetylchitobiose(out) => N,N'-diacetylchitobiose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15561", "l": "S-adenosyl-L-methionine + sterigmatocystin = 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.137251286633841", "identifiers": [{"i": "GO:0043236", "l": "laminin binding", "d": ["Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells."]}]}